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Search of human proteins with 25777728
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
(422 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 849 0.0
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 849 0.0
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 754 0.0
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 665 0.0
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 650 0.0
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 624 e-179
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 621 e-178
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 433 e-121
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 425 e-119
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 325 4e-89
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 305 7e-83
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 253 3e-67
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 243 2e-64
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 238 1e-62
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 190 2e-48
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 181 1e-45
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 151 9e-37
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 137 2e-32
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 137 2e-32
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 137 2e-32
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 136 3e-32
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 136 3e-32
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 136 3e-32
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 133 3e-31
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 133 3e-31
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 127 1e-29
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 127 1e-29
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 127 1e-29
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 122 5e-28
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 122 5e-28
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 849 bits (2193), Expect = 0.0
Identities = 422/422 (100%), Positives = 422/422 (100%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK
Sbjct: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
Query: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP
Sbjct: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
Query: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG
Sbjct: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
Query: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF
Sbjct: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
Query: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG
Sbjct: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
Query: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK
Sbjct: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
Query: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK
Sbjct: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
Query: 421 NS 422
NS
Sbjct: 421 NS 422
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 849 bits (2193), Expect = 0.0
Identities = 422/422 (100%), Positives = 422/422 (100%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK
Sbjct: 97 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 156
Query: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP
Sbjct: 157 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 216
Query: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG
Sbjct: 217 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 276
Query: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF
Sbjct: 277 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 336
Query: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG
Sbjct: 337 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 396
Query: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK
Sbjct: 397 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 456
Query: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK
Sbjct: 457 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 516
Query: 421 NS 422
NS
Sbjct: 517 NS 518
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 754 bits (1946), Expect = 0.0
Identities = 384/422 (90%), Positives = 384/422 (90%), Gaps = 38/422 (9%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK
Sbjct: 97 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 156
Query: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP
Sbjct: 157 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 216
Query: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
LSALYMGALIKE VGKLIQEAAG
Sbjct: 217 LSALYMGALIKE--------------------------------------VGKLIQEAAG 238
Query: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF
Sbjct: 239 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 298
Query: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG
Sbjct: 299 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 358
Query: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK
Sbjct: 359 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 418
Query: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK
Sbjct: 419 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 478
Query: 421 NS 422
NS
Sbjct: 479 NS 480
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 665 bits (1717), Expect = 0.0
Identities = 317/422 (75%), Positives = 374/422 (88%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
MDASERGRLL KLADL+ERDR +LATMES+NGGK + A+ DL G IKT RY AGWADK
Sbjct: 80 MDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADK 139
Query: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
I G TIP+DG++FT+TRHEPIGVCGQIIPWNFPL+M WKI PAL CGNTVV+KPAEQTP
Sbjct: 140 IQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199
Query: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
L+AL++ +LIKEAGFPPGV+NI+PGYGPTAGAAI+SH+ IDK+AFTGSTEVGKLI+EAAG
Sbjct: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG 259
Query: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
+SNLKRVTLELGGKSP I+ ADADLD AVE AH GVF++QGQCC A SRIFVEESIY+EF
Sbjct: 260 KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEF 319
Query: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
VRRSVERAK+ ++G+P P QGPQIDK+QY+KIL+LI+SG EGAKLECGG G KG
Sbjct: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKG 379
Query: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
+F++PTVFSNVTD+MRIAKEEIFGPVQ+I++FK++D+VI+RANN+ +GL A VFT DI+K
Sbjct: 380 YFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDK 439
Query: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
A+T+SSA+QAGTVW+NCY ++AQ PFGGFKMSGNGRE+GE+G EY+EVKTVTVKI QK
Sbjct: 440 AITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQK 499
Query: 421 NS 422
NS
Sbjct: 500 NS 501
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 650 bits (1676), Expect = 0.0
Identities = 309/421 (73%), Positives = 368/421 (87%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
+DA RGRLL +LADLVERDRA LA +E+++ GKPFL AF++DL+G I+T RY+AGWADK
Sbjct: 91 LDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADK 150
Query: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
I G TIP D + FTRHEPIGVCG I PWNFPLLM WK+APALCCGNT+V+KPAEQTP
Sbjct: 151 IQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTP 210
Query: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
L+ALY+G+LIKEAGFPPGV+NI+PG+GPT GAAI+SH I+KIAFTGSTEVGKL++EAA
Sbjct: 211 LTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAAS 270
Query: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
RSNLKRVTLELGGK+P I+ ADADLD AVE AHQGVFFNQGQCCTA SR+FVEE +Y EF
Sbjct: 271 RSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEF 330
Query: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
VRRSVE AK+R VG PFD TEQGPQID+KQ++KILELI+SG EGAKLECGG + KG
Sbjct: 331 VRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKG 390
Query: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
FI+PTVFS VTD+MRIAKEEIFGPVQ IL+FK+++EVI+RAN++D+GL AAVFT +++K
Sbjct: 391 LFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDK 450
Query: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
AL ++SA+++GTVWINCYNAL AQ+PFGGFKMSGNGRE+GE+ L EY+EVKTVT+K+ K
Sbjct: 451 ALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDK 510
Query: 421 N 421
N
Sbjct: 511 N 511
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 624 bits (1608), Expect = e-179
Identities = 295/422 (69%), Positives = 357/422 (84%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
MDAS RGRLL++LADL+ERDR LA +E+L+ GKP++ ++ VDL V+K RYYAGWADK
Sbjct: 96 MDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADK 155
Query: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
HG TIP+DGD+F++TRHEP+GVCGQIIPWNFPLLM AWK+ PAL GN VV+K AEQTP
Sbjct: 156 YHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTP 215
Query: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
L+ALY+ LIKEAGFPPGV+NI+PG+GPTAGAAIASH +DK+AFTGSTE+G++IQ AAG
Sbjct: 216 LTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAG 275
Query: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
SNLKRVTLELGGKSPNII +DAD+D+AVEQAH +FFNQGQCC AGSR FV+E IY+EF
Sbjct: 276 SSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEF 335
Query: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
V RSV RAK RVVG+PFD TEQGPQ+D+ Q+ KIL I +G EGAKL CGG +G
Sbjct: 336 VERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRG 395
Query: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
+FI+PTVF +V D M IAKEEIFGPV +IL+FKT++EV+ RANNS +GL AAVFT D++K
Sbjct: 396 YFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDK 455
Query: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
A +S A+QAGTVW+NCY+ AQSPFGG+KMSG+GRE+GE+GL+ Y+EVKTVTVK+PQK
Sbjct: 456 ANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQK 515
Query: 421 NS 422
NS
Sbjct: 516 NS 517
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 621 bits (1601), Expect = e-178
Identities = 290/422 (68%), Positives = 358/422 (84%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
MDASERGRLL++LADLVERDR LA++E+L+ GKPF +++ +DL VIK +RY+AGWADK
Sbjct: 96 MDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADK 155
Query: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
HG TIP+DG +F FTRHEP+GVCGQIIPWNFPL+M WK+APAL GNTVV+K AEQTP
Sbjct: 156 WHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTP 215
Query: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
LSALY+ +LIKEAGFPPGV+NI+ GYGPTAGAAIA H+ +DK+AFTGSTEVG LIQ+AAG
Sbjct: 216 LSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAG 275
Query: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
SNLKRVTLELGGKSP+I+ ADAD+++AVEQ H+ +FFN GQCC AGSR FVEESIY EF
Sbjct: 276 DSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEF 335
Query: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
+ R+VE+AK+R VG+PF+ T+QGPQ+DK+Q+ ++L IQ G EGAKL CGG+ G +G
Sbjct: 336 LERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERG 395
Query: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
FFI+PTVF V DDMRIAKEEIFGPVQ + +FK ++EV+ERANN+ +GL AAVFT D++K
Sbjct: 396 FFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDK 455
Query: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
A+ + A+QAGTVW+N YN + +PFGGFK SGNGRE+GE GL+ Y+EVKTVT+K+PQK
Sbjct: 456 AMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKVPQK 515
Query: 421 NS 422
NS
Sbjct: 516 NS 517
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 433 bits (1114), Expect = e-121
Identities = 223/420 (53%), Positives = 286/420 (68%), Gaps = 6/420 (1%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
+ A +RGRL+ +LADL+E+ + LAT+E+L+ G + A + I+TFRY+AGW DK
Sbjct: 480 ISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDK 539
Query: 61 IHGMTIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 116
I G TIP++ T TR EP+GVCG IIPWN+PL+M +WK A L GNTVVIKPA
Sbjct: 540 IQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPA 599
Query: 117 EQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQ 176
+ TPL+AL L +AG P GV+N+LPG G G ++ H + KI FTGSTEVGK I
Sbjct: 600 QVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIM 659
Query: 177 EAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESI 236
++ SN+K+V+LELGGKSP IIFAD DL+ AV+ VFFN+G+ C A R+FVE+SI
Sbjct: 660 KSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSI 719
Query: 237 YEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGL 296
++EFVRR VE ++ VG+P D T+ GPQ K++E Q GV EGA L CGG +
Sbjct: 720 HDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQV 779
Query: 297 GRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFK--TMDEVIERANNSDFGLVAAVF 354
R GFF EPTVF++V D M IAKEE FGPV I RF +D V+ RAN ++FGL + VF
Sbjct: 780 PRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVF 839
Query: 355 TNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 414
T DINKAL VS +QAGTV++N YN + +PFGGFK SG G+++GE L EY VKTVT
Sbjct: 840 TRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVT 899
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 425 bits (1093), Expect = e-119
Identities = 215/422 (50%), Positives = 292/422 (69%), Gaps = 6/422 (1%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
M+A ERGRL+ +LADL+E ++ LAT+E+L+ G + A + ++TFRY+AGW DK
Sbjct: 501 MNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDK 560
Query: 61 IHGMTIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 116
I G TIP++ TFT+ EP+GVC IIPWN+PL+M AWK A L GNT+V+KPA
Sbjct: 561 IQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPA 620
Query: 117 EQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQ 176
+ TPL+AL L +AGFP GVINI+PG G AG ++ H I K+ FTGST +GK I
Sbjct: 621 QVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIM 680
Query: 177 EAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESI 236
++ SNLK+V+LELGGKSP IIF D +LD AV VFFN+G+ C A R+FVEESI
Sbjct: 681 KSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESI 740
Query: 237 YEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGL 296
++EFV R VE K+ +G P D +T+ GPQ K K+L+ ++GV EGA L GG+ +
Sbjct: 741 HDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQV 800
Query: 297 GRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKT--MDEVIERANNSDFGLVAAVF 354
R GFF+EPTVF++V D M +AKEE FGP+ I +F+ +D V++RAN++++GL + VF
Sbjct: 801 QRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVF 860
Query: 355 TNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 414
T DINKA+ VS ++AGTV+IN YN + +PFGG K SG G+++GE L EY + KTVT
Sbjct: 861 TRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVT 920
Query: 415 VK 416
++
Sbjct: 921 LE 922
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 325 bits (834), Expect = 4e-89
Identities = 176/419 (42%), Positives = 249/419 (59%), Gaps = 9/419 (2%)
Query: 5 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 64
ER R+L + A ++ +ATME +N GK +A +D+ + YYAG A + G
Sbjct: 96 ERCRILLEAARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGE 154
Query: 65 TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSAL 124
I + G F +TR EP+GVC I WN+P + +WK APAL CGN +V KP+ TP+SAL
Sbjct: 155 HIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 214
Query: 125 YMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNL 184
+ + EAG PPG+ N++ G G G + H + K++FTGS G I E + + +
Sbjct: 215 LLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG-I 272
Query: 185 KRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRS 244
K VTLELGGKSP IIF+D D++ AV+ A F QGQ C G+R+FV++ I ++F
Sbjct: 273 KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEV 332
Query: 245 VERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLG------R 298
V++ +R +G P T GP I++ ++L ++ +GAK+ CGG +
Sbjct: 333 VKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLK 392
Query: 299 KGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDI 358
G+++ P V +N DDM KEEIFGPV IL F T EV+ERAN++ FGL A VFT DI
Sbjct: 393 DGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDI 452
Query: 359 NKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKI 417
+A V + +QAGT +IN YN + PFGG+K SG GRE G + YS++KTV V++
Sbjct: 453 QRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 511
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 305 bits (780), Expect = 7e-83
Identities = 165/422 (39%), Positives = 249/422 (59%), Gaps = 13/422 (3%)
Query: 5 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 64
ER R+L+++ADL+E+ A ES + GK A +D+ ++ FR++A + +H
Sbjct: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHT 125
Query: 65 TIPVDGDYFT---FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPL 121
+ D+ +T P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T +
Sbjct: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Query: 122 SALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGR 181
+A + L+ +AG PPGV+NI+ G GP G A+ SH + I+FTGS + I + +
Sbjct: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
Query: 182 SNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFV 241
+ K+++LELGGK+P IIF DA+LD + + F NQG+ C SRIFV++SIY EF+
Sbjct: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFL 304
Query: 242 RRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------K 294
+R VE ++ VG P DP G I K K+ ++ +AEGA++ CG
Sbjct: 305 KRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLP 364
Query: 295 GLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVF 354
+ G+F+ PTV +++ D+ EEIFGPV ++ F + +EVIERANN +GL A V+
Sbjct: 365 ARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVW 424
Query: 355 TNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 414
++++ + V+ +Q+G VW NC+ PFGG K SG GRE + ++E+KT+T
Sbjct: 425 SSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTIT 484
Query: 415 VK 416
VK
Sbjct: 485 VK 486
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 253 bits (645), Expect = 3e-67
Identities = 156/422 (36%), Positives = 227/422 (53%), Gaps = 15/422 (3%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW--- 57
+ A ER LL K +L+ +++ LA + + GKP +A G I ++ W
Sbjct: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSE 169
Query: 58 -ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKP 115
A +++G I D +PIGV I PWNFP M K+ AL G TVV+KP
Sbjct: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229
Query: 116 AEQTPLSALYMGALIKEAGFPPGVINILPGYGPTA---GAAIASHIGIDKIAFTGSTEVG 172
AE TP SAL + L +AG P GV N++P A G AI + + KI+FTGST G
Sbjct: 230 AEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTG 289
Query: 173 KLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFV 232
K++ A S +KRV++ELGG +P I+F A++D AV A F N GQ C ++ V
Sbjct: 290 KILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLV 348
Query: 233 EESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLEC 291
+ I++ FV+ E K+ + VG+ F+ T QGP I++K K+ + + V++GA +
Sbjct: 349 QRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVT 408
Query: 292 GGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVA 351
GGK F EPT+ NVT DM EE FGP+ +++F T +E I AN +D GL
Sbjct: 409 GGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAG 468
Query: 352 AVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVK 411
++ D + V+ ++ G V +N + + PFGG K SG GRE ++G+ EY E+K
Sbjct: 469 YFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELK 528
Query: 412 TV 413
V
Sbjct: 529 YV 530
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 243 bits (621), Expect = 2e-64
Identities = 156/435 (35%), Positives = 227/435 (52%), Gaps = 28/435 (6%)
Query: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW--- 57
+ A ER LL K +L+ +++ LA + + GKP +A G I ++ W
Sbjct: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSE 169
Query: 58 -ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKP 115
A +++G I D +PIGV I PWNFP M K+ AL G TVV+KP
Sbjct: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229
Query: 116 AEQTPLSALYMGA-------------LIKEAGFPPGVINILPGYGPTA---GAAIASHIG 159
AE TP SAL + L +AG P GV N++P A G AI +
Sbjct: 230 AEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL 289
Query: 160 IDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFN 219
+ KI+FTGST GK++ A S +KRV++ELGG +P I+F A++D AV A F N
Sbjct: 290 VSKISFTGSTTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRN 348
Query: 220 QGQCCTAGSRIFVEESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILEL 278
GQ C ++ V+ I++ FV+ E K+ + VG+ F+ T QGP I++K K+ +
Sbjct: 349 TGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQ 408
Query: 279 IQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEV 338
+ V++GA + GGK F EPT+ NVT DM EE FGP+ +++F T +E
Sbjct: 409 VNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEA 468
Query: 339 IERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGRE 398
I AN +D GL ++ D + V+ ++ G V +N + + PFGG K SG GRE
Sbjct: 469 IAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGRE 528
Query: 399 MGEFGLREYSEVKTV 413
++G+ EY E+K V
Sbjct: 529 GSKYGIDEYLELKYV 543
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 238 bits (606), Expect = 1e-62
Identities = 146/422 (34%), Positives = 221/422 (52%), Gaps = 67/422 (15%)
Query: 5 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 64
ER R+L+++ADL+E+ A ES + GK A +D+ ++ FR++A + +H
Sbjct: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHT 125
Query: 65 TIPVDGDYFT---FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPL 121
+ D+ +T P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T +
Sbjct: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Query: 122 SALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGR 181
+A + L+ +AG PPGV+NI+ G GP G A+ SH + I+FTGS + I + +
Sbjct: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
Query: 182 SNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFV 241
+ K+++LELGGK+P IIF DA+LD + + F NQ V
Sbjct: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQ--------------------V 284
Query: 242 RRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------K 294
R V+RA +AEGA++ CG
Sbjct: 285 RSYVKRA----------------------------------LAEGAQIWCGEGVDKLSLP 310
Query: 295 GLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVF 354
+ G+F+ PTV +++ D+ EEIFGPV ++ F + +EVIERANN +GL A V+
Sbjct: 311 ARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVW 370
Query: 355 TNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 414
++++ + V+ +Q+G VW NC+ PFGG K SG GRE + ++E+KT+T
Sbjct: 371 SSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTIT 430
Query: 415 VK 416
VK
Sbjct: 431 VK 432
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 190 bits (483), Expect = 2e-48
Identities = 131/424 (30%), Positives = 204/424 (48%), Gaps = 17/424 (4%)
Query: 3 ASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIH 62
A +RG ++ ++ D + VL ++ SL GK ++ ++Q + Y G + I
Sbjct: 107 APKRGEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIG 165
Query: 63 GMTIPVD-GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPL 121
G +P + + + P+G+ G I +NFP+ ++ W A A+ CGN + K A T L
Sbjct: 166 GPILPSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSL 225
Query: 122 SALYMGALIK---EAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGK----L 174
++ + +I E PG I L G G A+A ++ ++FTGST+VGK +
Sbjct: 226 ISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLM 285
Query: 175 IQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEE 234
+QE GRS LELGG + I F DADL V A GQ CT R+F+ E
Sbjct: 286 VQERFGRS-----LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHE 340
Query: 235 SIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGK 294
SI++E V R + + VG+P+DP GP K+ + L ++ EG + GGK
Sbjct: 341 SIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGK 400
Query: 295 GLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVF 354
+ R G ++EPT+ + + D IA E F P+ + +FK +EV N GL +++F
Sbjct: 401 VMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIF 460
Query: 355 TNDINKAL--TVSSAMQAGTVWINC-YNALNAQSPFGGFKMSGNGREMGEFGLREYSEVK 411
T D+ + G V +N + FGG K +G GRE G ++Y
Sbjct: 461 TKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRS 520
Query: 412 TVTV 415
T T+
Sbjct: 521 TCTI 524
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 181 bits (459), Expect = 1e-45
Identities = 124/420 (29%), Positives = 209/420 (49%), Gaps = 18/420 (4%)
Query: 6 RGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMT 65
R ++L + L++ + +A + +L GK A +G ++ + + G T
Sbjct: 101 RQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRG-LQVVEHACSVTSLMMGET 159
Query: 66 IP-VDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSAL 124
+P + D ++ P+GVC I P+NFP ++ W A+ CGNT ++KP+E+ P + +
Sbjct: 160 MPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATM 219
Query: 125 YMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNL 184
+ L++++G P G +NI+ G I H I I+F GS + G+ I E R
Sbjct: 220 LLAKLLQDSGAPDGTLNIIHGQHEAVN-FICDHPDIKAISFVGSNKAGEYIFERGSRHG- 277
Query: 185 KRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTA-GSRIFVEESIYEEFVRR 243
KRV +G K+ ++ DA+ + + Q F GQ C A + + V E+ ++++
Sbjct: 278 KRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPE 335
Query: 244 SVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGF-- 301
VE AK V + P + GP I + ++ LI SG EGA + G+ + KG+
Sbjct: 336 LVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYEN 395
Query: 302 --FIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDIN 359
F+ PT+ SNV +M KEEIFGPV +L +T+DE I+ NN+ +G A+FT +
Sbjct: 396 GNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGA 455
Query: 360 KALTVSSAMQAGTVWINCYNALNAQSPFGGFKMS-----GNGREMGEFGLREYSEVKTVT 414
A + + G V +N + P F S G+ G+ G++ Y+++KT+T
Sbjct: 456 TARKYAHLVDVGQVGVNV--PIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 151 bits (382), Expect = 9e-37
Identities = 119/404 (29%), Positives = 192/404 (47%), Gaps = 22/404 (5%)
Query: 6 RGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMT 65
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 101 RAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA---------- 150
Query: 66 IPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLSA 123
I EP+GV G I+P F L W+I PAL G TVV + PA PL
Sbjct: 151 IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPL-- 208
Query: 124 LYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSN 183
+ L E G PG++N+L G +AS GI K+AF G+ E G+ ++ +
Sbjct: 209 -LLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLA-GE 265
Query: 184 LKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRR 243
+ L LG +S ++ AD+D AVE + ++G G R+ ++ES+++E +RR
Sbjct: 266 CAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMRR 322
Query: 244 SVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFI 303
ER R G D + G + + + ++ ++GA++ G + F+
Sbjct: 323 LQERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFY- 380
Query: 304 EPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALT 363
PT+ SN+ A+ E+ PV F+T E + AN + G A+V++ + +AL
Sbjct: 381 PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALE 440
Query: 364 VSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREY 407
+ +Q GTVWIN + + P GG K SG G GL EY
Sbjct: 441 LGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 484
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/190 (31%), Positives = 84/190 (44%), Gaps = 10/190 (5%)
Query: 6 RGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIH--G 63
R LL LA +ER ++ LA+ G + V+L R W ++ G
Sbjct: 588 RAALLWALAAALERRKSTLASRLERQGAELKAAEAEVELSA-----RRLRAWGARVQAQG 642
Query: 64 MTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLS 122
T+ V G R EP+GV + P +PLL F +APAL GNTVV+ P+ PL
Sbjct: 643 HTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLL 702
Query: 123 ALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS 182
AL + + FP G+ N++ G +A H + + + GS + G E A
Sbjct: 703 ALEVCQDMATV-FPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQ-GSQFVEWASAG 760
Query: 183 NLKRVTLELG 192
NLK V G
Sbjct: 761 NLKPVWASRG 770
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 137 bits (344), Expect = 2e-32
Identities = 114/417 (27%), Positives = 199/417 (47%), Gaps = 25/417 (5%)
Query: 4 SERGRLLDKLADLVERDRAVLATMESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIH 62
++R ++ K AD++ R +++ G GK +QA +I FR+ A +A ++
Sbjct: 122 ADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELE 181
Query: 63 G---MTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQT 119
G +++P + + E G I P+NF + APAL GN V+ KP++
Sbjct: 182 GQQPISVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTA 238
Query: 120 PLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAA 179
L++ + +++EAG PP +I +P GP G + S + I FTGS K + +
Sbjct: 239 MLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 298
Query: 180 GRS-----NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEE 234
++ R+ E GGK+ + + AD++ V + F GQ C+A SR++V
Sbjct: 299 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 358
Query: 235 SIYEEFVRRSVERAKRRVVGSPF-DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECG 292
S++ + R +E R VG P D T ID K + +I + ++ + + + G
Sbjct: 359 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 418
Query: 293 GKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDF 347
GK G+F+EP + + I KEEIFGPV + ++K ++++ + + +
Sbjct: 419 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSY 476
Query: 348 GLVAAVFTNDINKALTVSSAMQ--AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 400
GL AVF+ D + + ++ AG +IN ++ Q PFGG + SG + G
Sbjct: 477 GLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 137 bits (344), Expect = 2e-32
Identities = 114/417 (27%), Positives = 199/417 (47%), Gaps = 25/417 (5%)
Query: 4 SERGRLLDKLADLVERDRAVLATMESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIH 62
++R ++ K AD++ R +++ G GK +QA +I FR+ A +A ++
Sbjct: 62 ADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELE 121
Query: 63 G---MTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQT 119
G +++P + + E G I P+NF + APAL GN V+ KP++
Sbjct: 122 GQQPISVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTA 178
Query: 120 PLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAA 179
L++ + +++EAG PP +I +P GP G + S + I FTGS K + +
Sbjct: 179 MLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 238
Query: 180 GRS-----NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEE 234
++ R+ E GGK+ + + AD++ V + F GQ C+A SR++V
Sbjct: 239 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 298
Query: 235 SIYEEFVRRSVERAKRRVVGSPF-DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECG 292
S++ + R +E R VG P D T ID K + +I + ++ + + + G
Sbjct: 299 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 358
Query: 293 GKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDF 347
GK G+F+EP + + I KEEIFGPV + ++K ++++ + + +
Sbjct: 359 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSY 416
Query: 348 GLVAAVFTNDINKALTVSSAMQ--AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 400
GL AVF+ D + + ++ AG +IN ++ Q PFGG + SG + G
Sbjct: 417 GLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 137 bits (344), Expect = 2e-32
Identities = 114/417 (27%), Positives = 199/417 (47%), Gaps = 25/417 (5%)
Query: 4 SERGRLLDKLADLVERDRAVLATMESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIH 62
++R ++ K AD++ R +++ G GK +QA +I FR+ A +A ++
Sbjct: 122 ADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELE 181
Query: 63 G---MTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQT 119
G +++P + + E G I P+NF + APAL GN V+ KP++
Sbjct: 182 GQQPISVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTA 238
Query: 120 PLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAA 179
L++ + +++EAG PP +I +P GP G + S + I FTGS K + +
Sbjct: 239 MLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 298
Query: 180 GRS-----NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEE 234
++ R+ E GGK+ + + AD++ V + F GQ C+A SR++V
Sbjct: 299 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 358
Query: 235 SIYEEFVRRSVERAKRRVVGSPF-DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECG 292
S++ + R +E R VG P D T ID K + +I + ++ + + + G
Sbjct: 359 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 418
Query: 293 GKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDF 347
GK G+F+EP + + I KEEIFGPV + ++K ++++ + + +
Sbjct: 419 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSY 476
Query: 348 GLVAAVFTNDINKALTVSSAMQ--AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 400
GL AVF+ D + + ++ AG +IN ++ Q PFGG + SG + G
Sbjct: 477 GLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 136 bits (343), Expect = 3e-32
Identities = 111/414 (26%), Positives = 191/414 (46%), Gaps = 19/414 (4%)
Query: 10 LDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAG----WADKIHGMT 65
L+ L L++ L + + K A+Y ++ V++ Y WA
Sbjct: 30 LEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEK 89
Query: 66 IPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALY 125
P + EP+GV I WN+P + + A+ GN+VV+KP+E + A
Sbjct: 90 TPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASL 149
Query: 126 MGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLK 185
+ +I + + ++ G P + D I +TGST VGK+I AA + +L
Sbjct: 150 LATIIPQY-LDKDLYPVINGGVPETTELLKERF--DHILYTGSTGVGKIIMTAAAK-HLT 205
Query: 186 RVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSV 245
VTLELGGKSP + + DLD A + G F N GQ C A I + SI + V + +
Sbjct: 206 PVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-L 264
Query: 246 ERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEP 305
+++ + G + + G I + + +++ G+ EG K+ GG G +I P
Sbjct: 265 KKSLKEFYGEDAKKSRDYGRIISARHFQRVM-----GLIEGQKVAYGGTG-DAATRYIAP 318
Query: 306 TVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTND---INKAL 362
T+ ++V + +EEIFGPV I+ ++++E I+ N + L +F+++ I K +
Sbjct: 319 TILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMI 378
Query: 363 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 416
+S+ + + L++ PFGG SG G G+ +S ++ V+
Sbjct: 379 AETSSGGVAANDVIVHITLHS-LPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 136 bits (343), Expect = 3e-32
Identities = 111/414 (26%), Positives = 191/414 (46%), Gaps = 19/414 (4%)
Query: 10 LDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAG----WADKIHGMT 65
L+ L L++ L + + K A+Y ++ V++ Y WA
Sbjct: 30 LEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEK 89
Query: 66 IPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALY 125
P + EP+GV I WN+P + + A+ GN+VV+KP+E + A
Sbjct: 90 TPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASL 149
Query: 126 MGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLK 185
+ +I + + ++ G P + D I +TGST VGK+I AA + +L
Sbjct: 150 LATIIPQY-LDKDLYPVINGGVPETTELLKERF--DHILYTGSTGVGKIIMTAAAK-HLT 205
Query: 186 RVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSV 245
VTLELGGKSP + + DLD A + G F N GQ C A I + SI + V + +
Sbjct: 206 PVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-L 264
Query: 246 ERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEP 305
+++ + G + + G I + + +++ G+ EG K+ GG G +I P
Sbjct: 265 KKSLKEFYGEDAKKSRDYGRIISARHFQRVM-----GLIEGQKVAYGGTG-DAATRYIAP 318
Query: 306 TVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTND---INKAL 362
T+ ++V + +EEIFGPV I+ ++++E I+ N + L +F+++ I K +
Sbjct: 319 TILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMI 378
Query: 363 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 416
+S+ + + L++ PFGG SG G G+ +S ++ V+
Sbjct: 379 AETSSGGVAANDVIVHITLHS-LPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 136 bits (343), Expect = 3e-32
Identities = 111/414 (26%), Positives = 191/414 (46%), Gaps = 19/414 (4%)
Query: 10 LDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAG----WADKIHGMT 65
L+ L L++ L + + K A+Y ++ V++ Y WA
Sbjct: 30 LEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEK 89
Query: 66 IPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALY 125
P + EP+GV I WN+P + + A+ GN+VV+KP+E + A
Sbjct: 90 TPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASL 149
Query: 126 MGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLK 185
+ +I + + ++ G P + D I +TGST VGK+I AA + +L
Sbjct: 150 LATIIPQY-LDKDLYPVINGGVPETTELLKERF--DHILYTGSTGVGKIIMTAAAK-HLT 205
Query: 186 RVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSV 245
VTLELGGKSP + + DLD A + G F N GQ C A I + SI + V + +
Sbjct: 206 PVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-L 264
Query: 246 ERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEP 305
+++ + G + + G I + + +++ G+ EG K+ GG G +I P
Sbjct: 265 KKSLKEFYGEDAKKSRDYGRIISARHFQRVM-----GLIEGQKVAYGGTG-DAATRYIAP 318
Query: 306 TVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTND---INKAL 362
T+ ++V + +EEIFGPV I+ ++++E I+ N + L +F+++ I K +
Sbjct: 319 TILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMI 378
Query: 363 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 416
+S+ + + L++ PFGG SG G G+ +S ++ V+
Sbjct: 379 AETSSGGVAANDVIVHITLHS-LPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 133 bits (334), Expect = 3e-31
Identities = 105/345 (30%), Positives = 162/345 (46%), Gaps = 15/345 (4%)
Query: 75 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134
+ + +P+GV I WN+P ++ + A+ GN V+IKP+E + +A + L+ +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
Query: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194
I I G T D I +TG+T VGK++ EAA + +L VTLELGGK
Sbjct: 156 DQDLYIVINGGVEETTELLKQR---FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
Query: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254
SP I D DLD + G + N GQ C A I E S+ + V + E K G
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYG 270
Query: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314
+ + I+ + + +IL L+ EG K+ GG+ +I PTV ++V
Sbjct: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPK 324
Query: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 374
++ +EEIFGP+ I+ K +DE I N + L VF+++ + +G V
Sbjct: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
Query: 375 IN---CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 416
N + LN+ PFGG SG G G+ +S + +K
Sbjct: 385 GNDVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 133 bits (334), Expect = 3e-31
Identities = 105/345 (30%), Positives = 162/345 (46%), Gaps = 15/345 (4%)
Query: 75 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134
+ + +P+GV I WN+P ++ + A+ GN V+IKP+E + +A + L+ +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
Query: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194
I I G T D I +TG+T VGK++ EAA + +L VTLELGGK
Sbjct: 156 DQDLYIVINGGVEETTELLKQR---FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
Query: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254
SP I D DLD + G + N GQ C A I E S+ + V + E K G
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYG 270
Query: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314
+ + I+ + + +IL L+ EG K+ GG+ +I PTV ++V
Sbjct: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPK 324
Query: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 374
++ +EEIFGP+ I+ K +DE I N + L VF+++ + +G V
Sbjct: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
Query: 375 IN---CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 416
N + LN+ PFGG SG G G+ +S + +K
Sbjct: 385 GNDVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 127 bits (320), Expect = 1e-29
Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 75 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
Query: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194
++ G GP + H D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
Query: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 273
Query: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
Query: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 374
+ +EEIFGP+ I+ +++DE IE N + L F+N V + +G
Sbjct: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
Query: 375 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 418
N + A PFGG SG GR G+F +S + ++ P
Sbjct: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 127 bits (320), Expect = 1e-29
Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 75 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
Query: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194
++ G GP + H D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 121 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 177
Query: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 236
Query: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 237 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 290
Query: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 374
+ +EEIFGP+ I+ +++DE IE N + L F+N V + +G
Sbjct: 291 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
Query: 375 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 418
N + A PFGG SG GR G+F +S + ++ P
Sbjct: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 396
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 127 bits (320), Expect = 1e-29
Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 75 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
Query: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194
++ G GP + H D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
Query: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 273
Query: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
Query: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 374
+ +EEIFGP+ I+ +++DE IE N + L F+N V + +G
Sbjct: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
Query: 375 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 418
N + A PFGG SG GR G+F +S + ++ P
Sbjct: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 122 bits (307), Expect = 5e-28
Identities = 98/342 (28%), Positives = 160/342 (46%), Gaps = 17/342 (4%)
Query: 75 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134
F EP G+ I PWN+PL + + AL G+ VV+KP+E + + + ++ +
Sbjct: 18 FIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY- 76
Query: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194
++ G GP + H +D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 77 LDQSCFAVVLG-GPQETGQLLEH-KLDYIFFTGSPRVGKIVMTAATK-HLTPVTLELGGK 133
Query: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 134 NPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYG 192
Query: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-NESDRYIAPTVLVDVQET 246
Query: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTND---INKAL-TVSSAMQA 370
+ +EEIFGP+ I+ +++DE I+ N + L F+N +N+ L SS
Sbjct: 247 EPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFG 306
Query: 371 GTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKT 412
G + L+ PFGG SG GR G+F +S +T
Sbjct: 307 GNEGFTYISLLSV--PFGGVGHSGMGRYHGKFTFDTFSHHRT 346
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 122 bits (307), Expect = 5e-28
Identities = 98/342 (28%), Positives = 160/342 (46%), Gaps = 17/342 (4%)
Query: 75 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 134
F EP G+ I PWN+PL + + AL G+ VV+KP+E + + + ++ +
Sbjct: 18 FIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY- 76
Query: 135 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 194
++ G GP + H +D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 77 LDQSCFAVVLG-GPQETGQLLEH-KLDYIFFTGSPRVGKIVMTAATK-HLTPVTLELGGK 133
Query: 195 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 254
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 134 NPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYG 192
Query: 255 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 314
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-NESDRYIAPTVLVDVQET 246
Query: 315 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTND---INKAL-TVSSAMQA 370
+ +EEIFGP+ I+ +++DE I+ N + L F+N +N+ L SS
Sbjct: 247 EPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFG 306
Query: 371 GTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKT 412
G + L+ PFGG SG GR G+F +S +T
Sbjct: 307 GNEGFTYISLLSV--PFGGVGHSGMGRYHGKFTFDTFSHHRT 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,598,319
Number of Sequences: 37866
Number of extensions: 705777
Number of successful extensions: 1415
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 1289
Number of HSP's gapped (non-prelim): 45
length of query: 422
length of database: 18,247,518
effective HSP length: 105
effective length of query: 317
effective length of database: 14,271,588
effective search space: 4524093396
effective search space used: 4524093396
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.