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Search of human proteins with 25777726
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
(480 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 963 0.0
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 944 0.0
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 754 0.0
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 671 0.0
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 665 0.0
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 623 e-178
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 621 e-178
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 413 e-115
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 409 e-114
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 299 4e-81
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 279 5e-75
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 228 7e-60
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 222 5e-58
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 212 7e-55
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 186 5e-47
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 180 3e-45
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 148 1e-35
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 140 3e-33
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 126 4e-29
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 126 4e-29
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 126 4e-29
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 117 2e-26
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 117 2e-26
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 108 1e-23
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 108 1e-23
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 108 1e-23
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 107 2e-23
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 107 2e-23
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 107 2e-23
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 102 8e-22
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 963 bits (2490), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP 60
MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
Sbjct: 1 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP 60
Query: 61 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 120
ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
Sbjct: 61 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 120
Query: 121 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC 180
ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
Sbjct: 121 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC 180
Query: 181 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVGKLIQEAAGRS 240
GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVGKLIQEAAGRS
Sbjct: 181 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVGKLIQEAAGRS 240
Query: 241 NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR 300
NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR
Sbjct: 241 NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR 300
Query: 301 RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF 360
RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF
Sbjct: 301 RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF 360
Query: 361 IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL 420
IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL
Sbjct: 361 IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL 420
Query: 421 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 480
TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
Sbjct: 421 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 480
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 944 bits (2441), Expect = 0.0
Identities = 480/518 (92%), Positives = 480/518 (92%), Gaps = 38/518 (7%)
Query: 1 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP 60
MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
Sbjct: 1 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP 60
Query: 61 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 120
ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
Sbjct: 61 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 120
Query: 121 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC 180
ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
Sbjct: 121 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC 180
Query: 181 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------ 228
GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE
Sbjct: 181 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP 240
Query: 229 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD 262
VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
Sbjct: 241 GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD 300
Query: 263 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG 322
LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
Sbjct: 301 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG 360
Query: 323 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG 382
PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
Sbjct: 361 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG 420
Query: 383 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ 442
PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
Sbjct: 421 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ 480
Query: 443 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 480
SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
Sbjct: 481 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 518
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 754 bits (1946), Expect = 0.0
Identities = 384/422 (90%), Positives = 384/422 (90%), Gaps = 38/422 (9%)
Query: 97 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 156
MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK
Sbjct: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
Query: 157 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 216
IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP
Sbjct: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
Query: 217 LSALYMGALIKE--------------------------------------VGKLIQEAAG 238
LSALYMGALIKE VGKLIQEAAG
Sbjct: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
Query: 239 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 298
RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF
Sbjct: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
Query: 299 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 358
VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG
Sbjct: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
Query: 359 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 418
FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK
Sbjct: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
Query: 419 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 478
ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK
Sbjct: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
Query: 479 NS 480
NS
Sbjct: 421 NS 422
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 671 bits (1730), Expect = 0.0
Identities = 329/493 (66%), Positives = 394/493 (79%), Gaps = 38/493 (7%)
Query: 26 LPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAAR 85
LP +L+I+YTKIFINNEW +S SG+ FPV+NPAT E++C+V+E DK D+DKAV+AAR
Sbjct: 9 LPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAAR 68
Query: 86 LAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIK 145
AF +GS WR MDASERGRLL KLADL+ERDR +LATMES+NGGK + A+ DL G IK
Sbjct: 69 QAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIK 128
Query: 146 TFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGN 205
T RY AGWADKI G TIP+DG++FT+TRHEPIGVCGQIIPWNFPL+M WKI PAL CGN
Sbjct: 129 TLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGN 188
Query: 206 TVVIKPAEQTPLSALYMGALIKE------------------------------------- 228
TVV+KPAEQTPL+AL++ +LIKE
Sbjct: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248
Query: 229 -VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSR 287
VGKLI+EAAG+SNLKRVTLELGGKSP I+ ADADLD AVE AH GVF++QGQCC A SR
Sbjct: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASR 308
Query: 288 IFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKL 347
IFVEESIY+EFVRRSVERAK+ ++G+P P QGPQIDK+QY+KIL+LI+SG EGAKL
Sbjct: 309 IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL 368
Query: 348 ECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGL 407
ECGG G KG+F++PTVFSNVTD+MRIAKEEIFGPVQ+I++FK++D+VI+RANN+ +GL
Sbjct: 369 ECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGL 428
Query: 408 VAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSE 467
A VFT DI+KA+T+SSA+QAGTVW+NCY ++AQ PFGGFKMSGNGRE+GE+G EY+E
Sbjct: 429 SAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTE 488
Query: 468 VKTVTVKIPQKNS 480
VKTVTVKI QKNS
Sbjct: 489 VKTVTVKISQKNS 501
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 665 bits (1716), Expect = 0.0
Identities = 324/492 (65%), Positives = 389/492 (79%), Gaps = 38/492 (7%)
Query: 26 LPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAAR 85
LP P NLE+K+TKIFINNEW S+SG+ F NP+T EQ+CEV+E DK D+DKAV+AA+
Sbjct: 20 LPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQ 79
Query: 86 LAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIK 145
+AF GS WRR+DA RGRLL +LADLVERDRA LA +E+++ GKPFL AF++DL+G I+
Sbjct: 80 VAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIR 139
Query: 146 TFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGN 205
T RY+AGWADKI G TIP D + FTRHEPIGVCG I PWNFPLLM WK+APALCCGN
Sbjct: 140 TLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGN 199
Query: 206 TVVIKPAEQTPLSALYMGALIKE------------------------------------- 228
T+V+KPAEQTPL+ALY+G+LIKE
Sbjct: 200 TMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGST 259
Query: 229 -VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSR 287
VGKL++EAA RSNLKRVTLELGGK+P I+ ADADLD AVE AHQGVFFNQGQCCTA SR
Sbjct: 260 EVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASR 319
Query: 288 IFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKL 347
+FVEE +Y EFVRRSVE AK+R VG PFD TEQGPQID+KQ++KILELI+SG EGAKL
Sbjct: 320 VFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKL 379
Query: 348 ECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGL 407
ECGG + KG FI+PTVFS VTD+MRIAKEEIFGPVQ IL+FK+++EVI+RAN++D+GL
Sbjct: 380 ECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGL 439
Query: 408 VAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSE 467
AAVFT +++KAL ++SA+++GTVWINCYNAL AQ+PFGGFKMSGNGRE+GE+ L EY+E
Sbjct: 440 TAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTE 499
Query: 468 VKTVTVKIPQKN 479
VKTVT+K+ KN
Sbjct: 500 VKTVTIKLGDKN 511
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 623 bits (1606), Expect = e-178
Identities = 304/498 (61%), Positives = 374/498 (75%), Gaps = 38/498 (7%)
Query: 21 ASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKA 80
A+ +P+P E+ +IFINNEW ++ S + FP NP+TGE +C+V E DK D+DKA
Sbjct: 20 AATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKA 79
Query: 81 VQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDL 140
V+AAR AF LGS WRRMDAS RGRLL++LADL+ERDR LA +E+L+ GKP++ ++ VDL
Sbjct: 80 VKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDL 139
Query: 141 QGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPA 200
V+K RYYAGWADK HG TIP+DGD+F++TRHEP+GVCGQIIPWNFPLLM AWK+ PA
Sbjct: 140 DMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPA 199
Query: 201 LCCGNTVVIKPAEQTPLSALYMGALIKE-------------------------------- 228
L GN VV+K AEQTPL+ALY+ LIKE
Sbjct: 200 LATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVA 259
Query: 229 ------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCC 282
+G++IQ AAG SNLKRVTLELGGKSPNII +DAD+D+AVEQAH +FFNQGQCC
Sbjct: 260 FTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCC 319
Query: 283 TAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVA 342
AGSR FV+E IY+EFV RSV RAK RVVG+PFD TEQGPQ+D+ Q+ KIL I +G
Sbjct: 320 CAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQ 379
Query: 343 EGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANN 402
EGAKL CGG +G+FI+PTVF +V D M IAKEEIFGPV +IL+FKT++EV+ RANN
Sbjct: 380 EGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANN 439
Query: 403 SDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGL 462
S +GL AAVFT D++KA +S A+QAGTVW+NCY+ AQSPFGG+KMSG+GRE+GE+GL
Sbjct: 440 STYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGL 499
Query: 463 REYSEVKTVTVKIPQKNS 480
+ Y+EVKTVTVK+PQKNS
Sbjct: 500 QAYTEVKTVTVKVPQKNS 517
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 621 bits (1601), Expect = e-178
Identities = 303/501 (60%), Positives = 378/501 (75%), Gaps = 38/501 (7%)
Query: 18 ALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADI 77
A +S LPSP N +I Y ++FINNEWQ++ S + FP NP TGE + V E D+AD+
Sbjct: 17 ARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADV 76
Query: 78 DKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFY 137
D+AV+AAR AF LGS WRRMDASERGRLL++LADLVERDR LA++E+L+ GKPF +++
Sbjct: 77 DRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYA 136
Query: 138 VDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKI 197
+DL VIK +RY+AGWADK HG TIP+DG +F FTRHEP+GVCGQIIPWNFPL+M WK+
Sbjct: 137 LDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKL 196
Query: 198 APALCCGNTVVIKPAEQTPLSALYMGALIKE----------------------------- 228
APAL GNTVV+K AEQTPLSALY+ +LIKE
Sbjct: 197 APALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVD 256
Query: 229 ---------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQG 279
VG LIQ+AAG SNLKRVTLELGGKSP+I+ ADAD+++AVEQ H+ +FFN G
Sbjct: 257 KVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMG 316
Query: 280 QCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQS 339
QCC AGSR FVEESIY EF+ R+VE+AK+R VG+PF+ T+QGPQ+DK+Q+ ++L IQ
Sbjct: 317 QCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQL 376
Query: 340 GVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIER 399
G EGAKL CGG+ G +GFFI+PTVF V DDMRIAKEEIFGPVQ + +FK ++EV+ER
Sbjct: 377 GQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVER 436
Query: 400 ANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGE 459
ANN+ +GL AAVFT D++KA+ + A+QAGTVW+N YN + +PFGGFK SGNGRE+GE
Sbjct: 437 ANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGE 496
Query: 460 FGLREYSEVKTVTVKIPQKNS 480
GL+ Y+EVKTVT+K+PQKNS
Sbjct: 497 DGLKAYTEVKTVTIKVPQKNS 517
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 413 bits (1061), Expect = e-115
Identities = 226/478 (47%), Positives = 296/478 (61%), Gaps = 45/478 (9%)
Query: 39 KIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMD 98
++FI E+ ++E + NP G +C+V A D+DKAV AA+ AF G W ++
Sbjct: 423 QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKIS 481
Query: 99 ASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIH 158
A +RGRL+ +LADL+E+ + LAT+E+L+ G + A + I+TFRY+AGW DKI
Sbjct: 482 ARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQ 541
Query: 159 GMTIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQ 214
G TIP++ T TR EP+GVCG IIPWN+PL+M +WK A L GNTVVIKPA+
Sbjct: 542 GSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQV 601
Query: 215 TPLSALYM--------------------GALI------------------KEVGKLIQEA 236
TPL+AL G+L+ EVGK I ++
Sbjct: 602 TPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
Query: 237 AGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYE 296
SN+K+V+LELGGKSP IIFAD DL+ AV+ VFFN+G+ C A R+FVE+SI++
Sbjct: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
Query: 297 EFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGR 356
EFVRR VE ++ VG+P D T+ GPQ K++E Q GV EGA L CGG + R
Sbjct: 722 EFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR 781
Query: 357 KGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFK--TMDEVIERANNSDFGLVAAVFTN 414
GFF EPTVF++V D M IAKEE FGPV I RF +D V+ RAN ++FGL + VFT
Sbjct: 782 PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTR 841
Query: 415 DINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 472
DINKAL VS +QAGTV++N YN + +PFGGFK SG G+++GE L EY VKTVT
Sbjct: 842 DINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVT 899
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 409 bits (1050), Expect = e-114
Identities = 216/478 (45%), Positives = 300/478 (62%), Gaps = 45/478 (9%)
Query: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
FIN ++ +++ G+ + NP G +C+V A AD+DKAV AA+ AF G W RM+A
Sbjct: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE-WGRMNAR 504
Query: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
ERGRL+ +LADL+E ++ LAT+E+L+ G + A + ++TFRY+AGW DKI G
Sbjct: 505 ERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGS 564
Query: 161 TIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 216
TIP++ TFT+ EP+GVC IIPWN+PL+M AWK A L GNT+V+KPA+ TP
Sbjct: 565 TIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTP 624
Query: 217 LSALYMGALIKE--------------------------------------VGKLIQEAAG 238
L+AL L + +GK I ++
Sbjct: 625 LTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCA 684
Query: 239 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 298
SNLK+V+LELGGKSP IIF D +LD AV VFFN+G+ C A R+FVEESI++EF
Sbjct: 685 VSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEF 744
Query: 299 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 358
V R VE K+ +G P D +T+ GPQ K K+L+ ++GV EGA L GG+ + R G
Sbjct: 745 VTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPG 804
Query: 359 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKT--MDEVIERANNSDFGLVAAVFTNDI 416
FF+EPTVF++V D M +AKEE FGP+ I +F+ +D V++RAN++++GL + VFT DI
Sbjct: 805 FFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDI 864
Query: 417 NKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 474
NKA+ VS ++AGTV+IN YN + +PFGG K SG G+++GE L EY + KTVT++
Sbjct: 865 NKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLE 922
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 299 bits (765), Expect = 4e-81
Identities = 188/516 (36%), Positives = 270/516 (52%), Gaps = 59/516 (11%)
Query: 12 VKADPAALMASLHLL-PSPTPNLEIKYTKIFINNEWQNSESG-RVFPV--------YNPA 61
++A AAL L L PSP + T F+ ++ N G RV P + PA
Sbjct: 3 LRAGLAALSPLLRSLRPSPVAAMS---TGTFVVSQPLNYRGGARVEPADASGTEKAFEPA 59
Query: 62 TGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLA 121
TG + + + +++ AVQ A+ AF +W + ER R+L + A ++ +A
Sbjct: 60 TGRVIATFTCSGEKEVNLAVQNAKAAFK---IWSQKSGMERCRILLEAARIIREREDEIA 116
Query: 122 TMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCG 181
TME +N GK +A +D+ + YYAG A + G I + G F +TR EP+GVC
Sbjct: 117 TMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCV 175
Query: 182 QIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG------KLIQE 235
I WN+P + +WK APAL CGN +V KP+ TP+SAL + + E G ++Q
Sbjct: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
Query: 236 AAGRSN------------------------------LKRVTLELGGKSPNIIFADADLDY 265
A +K VTLELGGKSP IIF+D D++
Sbjct: 236 GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNN 295
Query: 266 AVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQI 325
AV+ A F QGQ C G+R+FV++ I ++F V++ +R +G P T GP I
Sbjct: 296 AVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLI 355
Query: 326 DKKQYNKILELIQSGVAEGAKLECGGKGLG------RKGFFIEPTVFSNVTDDMRIAKEE 379
++ ++L ++ +GAK+ CGG + G+++ P V +N DDM KEE
Sbjct: 356 NRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEE 415
Query: 380 IFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNAL 439
IFGPV IL F T EV+ERAN++ FGL A VFT DI +A V + +QAGT +IN YN
Sbjct: 416 IFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVS 475
Query: 440 NAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKI 475
+ PFGG+K SG GRE G + YS++KTV V++
Sbjct: 476 PVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 511
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 279 bits (713), Expect = 5e-75
Identities = 165/464 (35%), Positives = 246/464 (53%), Gaps = 52/464 (11%)
Query: 58 YNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDR 117
Y+P+TGE C V + K +I+ AV+AAR AF W ER R+L+++ADL+E+
Sbjct: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSL 84
Query: 118 AVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFT---FTRH 174
A ES + GK A +D+ ++ FR++A + +H + D+ +T
Sbjct: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHTSECTQMDHLGCMHYTVR 142
Query: 175 EPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG---- 230
P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T ++A + L+ + G
Sbjct: 143 APVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPG 202
Query: 231 ----------------------KLIQEAAGRSNLKRVT-----------LELGGKSPNII 257
LI + +R+T LELGGK+P II
Sbjct: 203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAII 262
Query: 258 FADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDP 317
F DA+LD + + F NQG+ C SRIFV++SIY EF++R VE ++ VG P DP
Sbjct: 263 FEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDP 322
Query: 318 TTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------KGLGRKGFFIEPTVFSNVT 370
G I K K+ ++ +AEGA++ CG + G+F+ PTV +++
Sbjct: 323 LVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIK 382
Query: 371 DDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGT 430
D+ EEIFGPV ++ F + +EVIERANN +GL A V+++++ + V+ +Q+G
Sbjct: 383 DESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGL 442
Query: 431 VWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 474
VW NC+ PFGG K SG GRE + ++E+KT+TVK
Sbjct: 443 VWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 228 bits (582), Expect = 7e-60
Identities = 158/480 (32%), Positives = 234/480 (48%), Gaps = 56/480 (11%)
Query: 38 TKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRM 97
T F+ W + + FPV +PA+G + V + + AV+AA AF WR +
Sbjct: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
Query: 98 DASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW---- 153
A ER LL K +L+ +++ LA + + GKP +A G I ++ W
Sbjct: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSEE 170
Query: 154 ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 212
A +++G I D +PIGV I PWNFP M K+ AL G TVV+KPA
Sbjct: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230
Query: 213 EQTPLSALYMGALI--------------------KEVGKLI-------------QEAAGR 239
E TP SAL + L KEVG+ I G+
Sbjct: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290
Query: 240 -------SNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEE 292
+++KRV++ELGG +P I+F A++D AV A F N GQ C ++ V+
Sbjct: 291 ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQR 350
Query: 293 SIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG 351
I++ FV+ E K+ + VG+ F+ T QGP I++K K+ + + V++GA + GG
Sbjct: 351 GIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG 410
Query: 352 KGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAV 411
K F EPT+ NVT DM EE FGP+ +++F T +E I AN +D GL
Sbjct: 411 KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYF 470
Query: 412 FTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTV 471
++ D + V+ ++ G V +N + + PFGG K SG GRE ++G+ EY E+K V
Sbjct: 471 YSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 222 bits (566), Expect = 5e-58
Identities = 157/493 (31%), Positives = 234/493 (47%), Gaps = 69/493 (13%)
Query: 38 TKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRM 97
T F+ W + + FPV +PA+G + V + + AV+AA AF WR +
Sbjct: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
Query: 98 DASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW---- 153
A ER LL K +L+ +++ LA + + GKP +A G I ++ W
Sbjct: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSEE 170
Query: 154 ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 212
A +++G I D +PIGV I PWNFP M K+ AL G TVV+KPA
Sbjct: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230
Query: 213 EQTPLSALYMGAL---------------------------------IKEVGKLI------ 233
E TP SAL + + KEVG+ I
Sbjct: 231 EDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLV 290
Query: 234 -------QEAAGR-------SNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQG 279
G+ +++KRV++ELGG +P I+F A++D AV A F N G
Sbjct: 291 SKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTG 350
Query: 280 QCCTAGSRIFVEESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELIQ 338
Q C ++ V+ I++ FV+ E K+ + VG+ F+ T QGP I++K K+ + +
Sbjct: 351 QTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVN 410
Query: 339 SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIE 398
V++GA + GGK F EPT+ NVT DM EE FGP+ +++F T +E I
Sbjct: 411 DAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIA 470
Query: 399 RANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMG 458
AN +D GL ++ D + V+ ++ G V +N + + PFGG K SG GRE
Sbjct: 471 IANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGS 530
Query: 459 EFGLREYSEVKTV 471
++G+ EY E+K V
Sbjct: 531 KYGIDEYLELKYV 543
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 212 bits (539), Expect = 7e-55
Identities = 146/464 (31%), Positives = 218/464 (46%), Gaps = 106/464 (22%)
Query: 58 YNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDR 117
Y+P+TGE C V + K +I+ AV+AAR AF W ER R+L+++ADL+E+
Sbjct: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSL 84
Query: 118 AVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFT---FTRH 174
A ES + GK A +D+ ++ FR++A + +H + D+ +T
Sbjct: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHTSECTQMDHLGCMHYTVR 142
Query: 175 EPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG---- 230
P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T ++A + L+ + G
Sbjct: 143 APVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPG 202
Query: 231 ----------------------KLIQEAAGRSNLKRVT-----------LELGGKSPNII 257
LI + +R+T LELGGK+P II
Sbjct: 203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAII 262
Query: 258 FADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDP 317
F DA+LD + + F NQ VR V+RA
Sbjct: 263 FEDANLDECIPATVRSSFANQ--------------------VRSYVKRA----------- 291
Query: 318 TTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------KGLGRKGFFIEPTVFSNVT 370
+AEGA++ CG + G+F+ PTV +++
Sbjct: 292 -----------------------LAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIK 328
Query: 371 DDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGT 430
D+ EEIFGPV ++ F + +EVIERANN +GL A V+++++ + V+ +Q+G
Sbjct: 329 DESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGL 388
Query: 431 VWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 474
VW NC+ PFGG K SG GRE + ++E+KT+TVK
Sbjct: 389 VWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 186 bits (471), Expect = 5e-47
Identities = 134/480 (27%), Positives = 211/480 (43%), Gaps = 60/480 (12%)
Query: 43 NNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASER 102
N W G V Y PA E + V++A AD ++ V+ AR A+ +W + A +R
Sbjct: 56 NGSWGGR--GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWK---IWADIPAPKR 110
Query: 103 GRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTI 162
G ++ ++ D + VL ++ SL GK ++ ++Q + Y G + I G +
Sbjct: 111 GEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPIL 169
Query: 163 PVD-GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALY 221
P + + + P+G+ G I +NFP+ ++ W A A+ CGN + K A T L ++
Sbjct: 170 PSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVA 229
Query: 222 MGALI---------------------------------------------KEVGKLIQEA 236
+ +I K+VG ++QE
Sbjct: 230 VTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQER 289
Query: 237 AGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYE 296
GRS LELGG + I F DADL V A GQ CT R+F+ ESI++
Sbjct: 290 FGRS-----LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHD 344
Query: 297 EFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGR 356
E V R + + VG+P+DP GP K+ + L ++ EG + GGK + R
Sbjct: 345 EVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDR 404
Query: 357 KGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDI 416
G ++EPT+ + + D IA E F P+ + +FK +EV N GL +++FT D+
Sbjct: 405 PGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDL 464
Query: 417 NKAL--TVSSAMQAGTVWINC-YNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTV 473
+ G V +N + FGG K +G GRE G ++Y T T+
Sbjct: 465 GRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 180 bits (456), Expect = 3e-45
Identities = 137/515 (26%), Positives = 236/515 (45%), Gaps = 64/515 (12%)
Query: 6 IEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQ 65
+++ +VK+ P AS PT K+FI ++ S+S + ++NPAT E
Sbjct: 15 LQVSSKVKSSPTWYSASSFSSSVPT-------VKLFIGGKFVESKSDKWIDIHNPATNEV 67
Query: 66 VCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMES 125
+ V +A KA++D A+ + + AF W R ++L + L++ + +A + +
Sbjct: 68 IGRVPQATKAEMDAAIASCKRAFP---AWADTSVLSRQQVLLRYQQLIKENLKEIAKLIT 124
Query: 126 LNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIP-VDGDYFTFTRHEPIGVCGQII 184
L GK A +G ++ + + G T+P + D ++ P+GVC I
Sbjct: 125 LEQGKTLADAEGDVFRG-LQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIA 183
Query: 185 PWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE---------------- 228
P+NFP ++ W A+ CGNT ++KP+E+ P + + + L+++
Sbjct: 184 PFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHE 243
Query: 229 ---------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAV 267
G+ I E R KRV +G K+ ++ DA+ + +
Sbjct: 244 AVNFICDHPDIKAISFVGSNKAGEYIFERGSRHG-KRVQANMGAKNHGVVMPDANKENTL 302
Query: 268 EQAHQGVFFNQGQCCTA-GSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQID 326
Q F GQ C A + + V E+ ++++ VE AK V + P + GP I
Sbjct: 303 NQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGADLGPLIT 360
Query: 327 KKQYNKILELIQSGVAEGAKLECGGKGLGRKGF----FIEPTVFSNVTDDMRIAKEEIFG 382
+ ++ LI SG EGA + G+ + KG+ F+ PT+ SNV +M KEEIFG
Sbjct: 361 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG 420
Query: 383 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ 442
PV +L +T+DE I+ NN+ +G A+FT + A + + G V +N +
Sbjct: 421 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNV--PIPVP 478
Query: 443 SPFGGFKMS-----GNGREMGEFGLREYSEVKTVT 472
P F S G+ G+ G++ Y+++KT+T
Sbjct: 479 LPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 148 bits (373), Expect = 1e-35
Identities = 122/460 (26%), Positives = 200/460 (43%), Gaps = 53/460 (11%)
Query: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
++N +W E P +P TGE + +A D+ AV+AAR+AF W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
Query: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
Query: 161 TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLS 218
I EP+GV G I+P F L W+I PAL G TVV + PA PL
Sbjct: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLL 209
Query: 219 ALYMGA----------LIKEVGKLIQEAAGRSNLKRVT---------------------- 246
+ ++ L+ A + +++V
Sbjct: 210 LAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAEL 269
Query: 247 -LELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVER 305
L LG +S ++ AD+D AVE + ++G G R+ ++ES+++E +RR ER
Sbjct: 270 GLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMRRLQER 326
Query: 306 AKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTV 365
R G D + G + + + ++ ++GA++ G + F+ PT+
Sbjct: 327 MGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFY-PPTL 384
Query: 366 FSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSA 425
SN+ A+ E+ PV F+T E + AN + G A+V++ + +AL +
Sbjct: 385 VSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYG 444
Query: 426 MQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREY 465
+Q GTVWIN + + P GG K SG G GL EY
Sbjct: 445 LQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 484
Score = 67.0 bits (162), Expect = 4e-11
Identities = 65/210 (30%), Positives = 91/210 (43%), Gaps = 17/210 (8%)
Query: 14 ADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEAD 73
A P+ L A + PSP P + F+ +Q + P+ + ++G V E
Sbjct: 509 AVPSTLPAGPEIGPSPAPPYGL-----FVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGG 562
Query: 74 KADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFL 133
DI AV+AA AF W R LL LA +ER ++ LA+ G +
Sbjct: 563 AKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKA 619
Query: 134 QAFYVDLQGVIKTFRYYAGWADKIH--GMTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPL 190
V+L R W ++ G T+ V G R EP+GV + P +PL
Sbjct: 620 AEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 674
Query: 191 LMFAWKIAPALCCGNTVVIKPAEQTPLSAL 220
L F +APAL GNTVV+ P+ PL AL
Sbjct: 675 LAFVSLLAPALAYGNTVVMVPSAACPLLAL 704
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 140 bits (353), Expect = 3e-33
Identities = 113/427 (26%), Positives = 185/427 (43%), Gaps = 38/427 (8%)
Query: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
++N +W E P +P TGE + +A D+ AV+AAR+AF W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
Query: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
Query: 161 TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLS 218
I EP+GV G I+P F L W+I PAL G TVV + PA PL
Sbjct: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLL 209
Query: 219 ALYMGALIKEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQ 278
+ + ++ +G ++L + G + F A
Sbjct: 210 LAQLAGELGPFPGILNVLSGPASLVPILASQPG-IRKVAFCGAP---------------- 252
Query: 279 GQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQ 338
G R+ ++ES+++E +RR ER R G D + G + + + ++
Sbjct: 253 ----EGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVR 307
Query: 339 SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIE 398
++GA++ G + F+ PT+ SN+ A+ E+ PV F+T E +
Sbjct: 308 EAQSQGAQVFQAGDVPSERPFY-PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALL 366
Query: 399 RANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMG 458
AN + G A+V++ + +AL + +Q GTVWIN + + P GG K SG G
Sbjct: 367 VANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGG 426
Query: 459 EFGLREY 465
GL EY
Sbjct: 427 PDGLYEY 433
Score = 67.0 bits (162), Expect = 4e-11
Identities = 65/210 (30%), Positives = 91/210 (43%), Gaps = 17/210 (8%)
Query: 14 ADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEAD 73
A P+ L A + PSP P + F+ +Q + P+ + ++G V E
Sbjct: 458 AVPSTLPAGPEIGPSPAPPYGL-----FVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGG 511
Query: 74 KADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFL 133
DI AV+AA AF W R LL LA +ER ++ LA+ G +
Sbjct: 512 AKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKA 568
Query: 134 QAFYVDLQGVIKTFRYYAGWADKIH--GMTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPL 190
V+L R W ++ G T+ V G R EP+GV + P +PL
Sbjct: 569 AEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 623
Query: 191 LMFAWKIAPALCCGNTVVIKPAEQTPLSAL 220
L F +APAL GNTVV+ P+ PL AL
Sbjct: 624 LAFVSLLAPALAYGNTVVMVPSAACPLLAL 653
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 126 bits (317), Expect = 4e-29
Identities = 114/440 (25%), Positives = 192/440 (43%), Gaps = 54/440 (12%)
Query: 77 IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 136
I +AV+ AR AFS G R R + L+ L L++ L + + K A+
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 137 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 192
Y ++ V++ Y WA P + EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 193 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------------------ 228
+ A+ GN+VV+KP+E + A + +I +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 229 -----------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFN 277
VGK+I AA + +L VTLELGGKSP + + DLD A + G F N
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
Query: 278 QGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELI 337
GQ C A I + SI + V + ++++ + G + + G I + + +++
Sbjct: 240 SGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM--- 295
Query: 338 QSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVI 397
G+ EG K+ GG G +I PT+ ++V + +EEIFGPV I+ ++++E I
Sbjct: 296 --GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAI 352
Query: 398 ERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNG 454
+ N + L +F+++ I K + +S+ + + L++ PFGG SG G
Sbjct: 353 QFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNSGMG 411
Query: 455 REMGEFGLREYSEVKTVTVK 474
G+ +S ++ V+
Sbjct: 412 SYHGKKSFETFSHRRSCLVR 431
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 126 bits (317), Expect = 4e-29
Identities = 114/440 (25%), Positives = 192/440 (43%), Gaps = 54/440 (12%)
Query: 77 IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 136
I +AV+ AR AFS G R R + L+ L L++ L + + K A+
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 137 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 192
Y ++ V++ Y WA P + EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 193 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------------------ 228
+ A+ GN+VV+KP+E + A + +I +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 229 -----------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFN 277
VGK+I AA + +L VTLELGGKSP + + DLD A + G F N
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
Query: 278 QGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELI 337
GQ C A I + SI + V + ++++ + G + + G I + + +++
Sbjct: 240 SGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM--- 295
Query: 338 QSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVI 397
G+ EG K+ GG G +I PT+ ++V + +EEIFGPV I+ ++++E I
Sbjct: 296 --GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAI 352
Query: 398 ERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNG 454
+ N + L +F+++ I K + +S+ + + L++ PFGG SG G
Sbjct: 353 QFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNSGMG 411
Query: 455 REMGEFGLREYSEVKTVTVK 474
G+ +S ++ V+
Sbjct: 412 SYHGKKSFETFSHRRSCLVR 431
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 126 bits (317), Expect = 4e-29
Identities = 114/440 (25%), Positives = 192/440 (43%), Gaps = 54/440 (12%)
Query: 77 IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 136
I +AV+ AR AFS G R R + L+ L L++ L + + K A+
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 137 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 192
Y ++ V++ Y WA P + EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 193 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------------------ 228
+ A+ GN+VV+KP+E + A + +I +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 229 -----------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFN 277
VGK+I AA + +L VTLELGGKSP + + DLD A + G F N
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
Query: 278 QGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELI 337
GQ C A I + SI + V + ++++ + G + + G I + + +++
Sbjct: 240 SGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM--- 295
Query: 338 QSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVI 397
G+ EG K+ GG G +I PT+ ++V + +EEIFGPV I+ ++++E I
Sbjct: 296 --GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAI 352
Query: 398 ERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNG 454
+ N + L +F+++ I K + +S+ + + L++ PFGG SG G
Sbjct: 353 QFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNSGMG 411
Query: 455 REMGEFGLREYSEVKTVTVK 474
G+ +S ++ V+
Sbjct: 412 SYHGKKSFETFSHRRSCLVR 431
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 117 bits (294), Expect = 2e-26
Identities = 96/342 (28%), Positives = 151/342 (44%), Gaps = 47/342 (13%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228
+ + +P+GV I WN+P ++ + A+ GN V+IKP+E + +A + L+ +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
Query: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255
VGK++ EAA + +L VTLELGGKSP
Sbjct: 156 DQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPC 214
Query: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
I D DLD + G + N GQ C A I E S+ + V + E K G
Sbjct: 215 YIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYGENI 273
Query: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375
+ + I+ + + +IL L+ EG K+ GG+ +I PTV ++V ++
Sbjct: 274 KESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPKTKV 327
Query: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN- 434
+EEIFGP+ I+ K +DE I N + L VF+++ + +G V N
Sbjct: 328 MQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGND 387
Query: 435 --CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 474
+ LN+ PFGG SG G G+ +S + +K
Sbjct: 388 VIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 117 bits (294), Expect = 2e-26
Identities = 96/342 (28%), Positives = 151/342 (44%), Gaps = 47/342 (13%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228
+ + +P+GV I WN+P ++ + A+ GN V+IKP+E + +A + L+ +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
Query: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255
VGK++ EAA + +L VTLELGGKSP
Sbjct: 156 DQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGKSPC 214
Query: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
I D DLD + G + N GQ C A I E S+ + V + E K G
Sbjct: 215 YIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYGENI 273
Query: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375
+ + I+ + + +IL L+ EG K+ GG+ +I PTV ++V ++
Sbjct: 274 KESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPKTKV 327
Query: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN- 434
+EEIFGP+ I+ K +DE I N + L VF+++ + +G V N
Sbjct: 328 MQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGND 387
Query: 435 --CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 474
+ LN+ PFGG SG G G+ +S + +K
Sbjct: 388 VIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 108 bits (270), Expect = 1e-23
Identities = 89/343 (25%), Positives = 145/343 (42%), Gaps = 45/343 (13%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYV 158
Query: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255
VGK++ AA + +L VTLELGGK+P
Sbjct: 159 DQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGKNPC 217
Query: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
+ + D + +FN GQ C A + + E + +++ R G
Sbjct: 218 YVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDP 276
Query: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V + +
Sbjct: 277 QSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEMEPV 330
Query: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN- 434
+EEIFGP+ I+ +++DE IE N + L F+N V + +G N
Sbjct: 331 MQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND 390
Query: 435 -CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 476
+ A PFGG SG GR G+F +S + ++ P
Sbjct: 391 GFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 108 bits (270), Expect = 1e-23
Identities = 89/343 (25%), Positives = 145/343 (42%), Gaps = 45/343 (13%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYV 121
Query: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255
VGK++ AA + +L VTLELGGK+P
Sbjct: 122 DQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGKNPC 180
Query: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
+ + D + +FN GQ C A + + E + +++ R G
Sbjct: 181 YVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDP 239
Query: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V + +
Sbjct: 240 QSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEMEPV 293
Query: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN- 434
+EEIFGP+ I+ +++DE IE N + L F+N V + +G N
Sbjct: 294 MQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND 353
Query: 435 -CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 476
+ A PFGG SG GR G+F +S + ++ P
Sbjct: 354 GFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 396
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 108 bits (270), Expect = 1e-23
Identities = 89/343 (25%), Positives = 145/343 (42%), Gaps = 45/343 (13%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYV 158
Query: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255
VGK++ AA + +L VTLELGGK+P
Sbjct: 159 DQSCFAVVLGGPQETGQLLEHRFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGKNPC 217
Query: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
+ + D + +FN GQ C A + + E + +++ R G
Sbjct: 218 YVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDP 276
Query: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V + +
Sbjct: 277 QSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEMEPV 330
Query: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN- 434
+EEIFGP+ I+ +++DE IE N + L F+N V + +G N
Sbjct: 331 MQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGND 390
Query: 435 -CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 476
+ A PFGG SG GR G+F +S + ++ P
Sbjct: 391 GFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 107 bits (268), Expect = 2e-23
Identities = 111/454 (24%), Positives = 197/454 (43%), Gaps = 66/454 (14%)
Query: 63 GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122
G +V + ADK+ ++KA++AA A W ++R ++ K AD++ R
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
Query: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178
+++ G GK +QA +I FR+ A +A ++ G +++P + + E G
Sbjct: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
Query: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG-------- 230
I P+NF + APAL GN V+ KP++ L++ + +++E G
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 231 -----------------------------------KLIQEAAGRSNLKRVTLELGGKSPN 255
++ Q R+ E GGK+ +
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
+ AD++ V + F GQ C+A SR++V S++ + R +E R VG P
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 316 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 373
D T ID K + +I + ++ + + + GGK G+F+EP + +
Sbjct: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
Query: 374 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 427
I KEEIFGPV + ++K ++++ + + +GL AVF+ D + + ++
Sbjct: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
Query: 428 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 458
AG +IN ++ Q PFGG + SG + G
Sbjct: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 107 bits (268), Expect = 2e-23
Identities = 111/454 (24%), Positives = 197/454 (43%), Gaps = 66/454 (14%)
Query: 63 GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122
G +V + ADK+ ++KA++AA A W ++R ++ K AD++ R
Sbjct: 28 GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 84
Query: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178
+++ G GK +QA +I FR+ A +A ++ G +++P + + E G
Sbjct: 85 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 142
Query: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG-------- 230
I P+NF + APAL GN V+ KP++ L++ + +++E G
Sbjct: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
Query: 231 -----------------------------------KLIQEAAGRSNLKRVTLELGGKSPN 255
++ Q R+ E GGK+ +
Sbjct: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
Query: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
+ AD++ V + F GQ C+A SR++V S++ + R +E R VG P
Sbjct: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
Query: 316 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 373
D T ID K + +I + ++ + + + GGK G+F+EP + +
Sbjct: 322 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 381
Query: 374 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 427
I KEEIFGPV + ++K ++++ + + +GL AVF+ D + + ++
Sbjct: 382 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 439
Query: 428 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 458
AG +IN ++ Q PFGG + SG + G
Sbjct: 440 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 107 bits (268), Expect = 2e-23
Identities = 111/454 (24%), Positives = 197/454 (43%), Gaps = 66/454 (14%)
Query: 63 GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122
G +V + ADK+ ++KA++AA A W ++R ++ K AD++ R
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
Query: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178
+++ G GK +QA +I FR+ A +A ++ G +++P + + E G
Sbjct: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
Query: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG-------- 230
I P+NF + APAL GN V+ KP++ L++ + +++E G
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 231 -----------------------------------KLIQEAAGRSNLKRVTLELGGKSPN 255
++ Q R+ E GGK+ +
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
+ AD++ V + F GQ C+A SR++V S++ + R +E R VG P
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 316 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 373
D T ID K + +I + ++ + + + GGK G+F+EP + +
Sbjct: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
Query: 374 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 427
I KEEIFGPV + ++K ++++ + + +GL AVF+ D + + ++
Sbjct: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
Query: 428 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 458
AG +IN ++ Q PFGG + SG + G
Sbjct: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 102 bits (254), Expect = 8e-22
Identities = 88/339 (25%), Positives = 146/339 (43%), Gaps = 49/339 (14%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE-- 228
F EP G+ I PWN+PL + + AL G+ VV+KP+E + + + ++ +
Sbjct: 18 FIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQYL 77
Query: 229 ---------------------------------VGKLIQEAAGRSNLKRVTLELGGKSPN 255
VGK++ AA + +L VTLELGGK+P
Sbjct: 78 DQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATK-HLTPVTLELGGKNPC 136
Query: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
+ + D + +FN GQ C A + + E + +++ R G
Sbjct: 137 YVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYGDDP 195
Query: 316 DPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRI 375
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V + +
Sbjct: 196 QSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-NESDRYIAPTVLVDVQETEPV 249
Query: 376 AKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTND---INKAL-TVSSAMQAGTV 431
+EEIFGP+ I+ +++DE I+ N + L F+N +N+ L SS G
Sbjct: 250 MQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGGNE 309
Query: 432 WINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKT 470
+ L+ PFGG SG GR G+F +S +T
Sbjct: 310 GFTYISLLSV--PFGGVGHSGMGRYHGKFTFDTFSHHRT 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,492,758
Number of Sequences: 37866
Number of extensions: 764764
Number of successful extensions: 1571
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1439
Number of HSP's gapped (non-prelim): 69
length of query: 480
length of database: 18,247,518
effective HSP length: 106
effective length of query: 374
effective length of database: 14,233,722
effective search space: 5323412028
effective search space used: 5323412028
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.