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Search of human proteins with 25777721
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor
[Homo sapiens]
(548 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 1097 0.0
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 1062 0.0
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 276 3e-74
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 268 1e-71
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 265 1e-70
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 260 3e-69
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 259 4e-69
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 252 5e-67
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 251 9e-67
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 249 4e-66
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 248 1e-65
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 243 3e-64
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 222 6e-58
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 219 4e-57
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 189 6e-48
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 175 1e-43
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 137 3e-32
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 134 2e-31
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 134 2e-31
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 134 2e-31
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 134 3e-31
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 134 3e-31
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 128 1e-29
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 127 2e-29
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 127 2e-29
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 125 1e-28
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 125 1e-28
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 100 3e-21
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 89 8e-18
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 89 8e-18
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 1097 bits (2837), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 1 MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR 60
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
Sbjct: 1 MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR 60
Query: 61 TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120
TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
Sbjct: 61 TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120
Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180
SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
Sbjct: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180
Query: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240
TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
Sbjct: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240
Query: 241 AEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 300
AEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT
Sbjct: 241 AEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 300
Query: 301 TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 360
TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL
Sbjct: 301 TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 360
Query: 361 VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV 420
VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV
Sbjct: 361 VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV 420
Query: 421 TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 480
TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA
Sbjct: 421 TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 480
Query: 481 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 540
GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL
Sbjct: 481 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 540
Query: 541 KYVCYGGL 548
KYVCYGGL
Sbjct: 541 KYVCYGGL 548
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 1062 bits (2747), Expect = 0.0
Identities = 535/548 (97%), Positives = 535/548 (97%), Gaps = 13/548 (2%)
Query: 1 MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR 60
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR
Sbjct: 1 MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLR 60
Query: 61 TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120
TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER
Sbjct: 61 TDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKER 120
Query: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180
SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH
Sbjct: 121 SSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIH 180
Query: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240
TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL
Sbjct: 181 TPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALAL 240
Query: 241 AEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 300
AE LASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT
Sbjct: 241 AE-------------LASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTT 287
Query: 301 TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 360
TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL
Sbjct: 288 TGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFL 347
Query: 361 VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV 420
VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV
Sbjct: 348 VQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVV 407
Query: 421 TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 480
TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA
Sbjct: 408 TGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 467
Query: 481 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 540
GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL
Sbjct: 468 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527
Query: 541 KYVCYGGL 548
KYVCYGGL
Sbjct: 528 KYVCYGGL 535
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 276 bits (707), Expect = 3e-74
Identities = 170/496 (34%), Positives = 271/496 (54%), Gaps = 27/496 (5%)
Query: 57 ALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116
ALL ++F+ G++LP ++ DP++G V + G E AAV+AA EAF W S
Sbjct: 6 ALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRS 65
Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175
+ERS +L + +L+ Q+ ++ A+ + + GK L A +I S +F+ +
Sbjct: 66 PQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHT 125
Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
+ ++ P+GVA +I+PWN P ++T K+ A+AAG TV+ KP+E T
Sbjct: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Query: 236 SALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISF 295
+A L + L +AG+P GV N++ VGEA+ + P V ISF
Sbjct: 186 TAWMLCK-------------LLDKAGVPPGVVNIV---FGTGPRVGEALVSHPEVPLISF 229
Query: 296 TGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVC 355
TGS T + + +A K++S+ELGG P I+F+ AN+D+ + + S F N G+ C+C
Sbjct: 230 TGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLC 289
Query: 356 SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSK 415
+++ VQ+ I+ F+K F EA +K +VG + + G LI++ +EKV V A+++
Sbjct: 290 TSRIFVQKSIYSEFLKRFVEATRK-WKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAE 348
Query: 416 GATVVTGG--------KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEE 467
GA + G R+Q G F PT++ ++ + C EE FGP+ V+ FD+EEE
Sbjct: 349 GAQIWCGEGVDKLSLPARNQAGY-FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEE 407
Query: 468 AIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGR 527
I AN GLA +S + ++ RVA++L+ G+V N LI + PFGG+K SG+GR
Sbjct: 408 VIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGR 467
Query: 528 EGSKYGIDEYLELKYV 543
EG+K D + E+K +
Sbjct: 468 EGAKDSYDFFTEIKTI 483
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 268 bits (684), Expect = 1e-71
Identities = 176/493 (35%), Positives = 274/493 (55%), Gaps = 28/493 (5%)
Query: 64 FVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWREVSAKE 119
F+GG ++ A A T +P G+ + V+ V + AV AA +AF RW ++SA++
Sbjct: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDI 178
R L+ + +LM Q++++LA I ++G A + S +F+ ++ G
Sbjct: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
Query: 179 IH-TPAKDRRALVL--KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
I A+ R L L K+P+GV +I PWN+P M++ K A LAAG TVV+KPA+ TP
Sbjct: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPL 604
Query: 236 SALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISF 295
+AL AE L +AGIP GV NV+P S VG+ + P V KI F
Sbjct: 605 TALKFAE-------------LTLKAGIPKGVVNVLPGS---GSLVGQRLSDHPDVRKIGF 648
Query: 296 TGSTTTGK-ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCV 354
TGST GK I+ A ++VK+VS+ELGG +P I+F ++++AV M+S F N G+ C+
Sbjct: 649 TGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCI 708
Query: 355 CSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVS 414
+ + V+ IHD FV+ E ++K ++VGN + T GP + + K+ + V
Sbjct: 709 AAGRLFVEDSIHDEFVRRVVEEVRK-MKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVK 767
Query: 415 KGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKF-DTEEEAI-AIA 472
+GAT+V GG + FFEPT+ +V M EE+FGP+ + +F D + +A+ + A
Sbjct: 768 EGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRA 827
Query: 473 NAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKY 532
NA + GLA +++D + V+++L+ G V VN + V PFGG KQSG G++ +
Sbjct: 828 NATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEA 887
Query: 533 GIDEYLELKYVCY 545
++EYL +K V +
Sbjct: 888 ALNEYLRVKTVTF 900
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 265 bits (676), Expect = 1e-70
Identities = 174/494 (35%), Positives = 254/494 (51%), Gaps = 33/494 (6%)
Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
T F+ W + + FPV +PA+G + V + + AV+AA AF WR +
Sbjct: 38 TKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRM 97
Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSEE 170
A ER LL K +L+ +++ LA + + GKP +A G I ++ W
Sbjct: 98 DASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW---- 153
Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230
A +++G I D +PIGV I PWNFP M K+ AL G TVV+KPA
Sbjct: 154 ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 212
Query: 231 EDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLV 290
E TP SAL + L +AG P GV N++P A G AI + +
Sbjct: 213 EQTPLSALYMGA-------------LIKEAGFPPGVINILPGYGPTA---GAAIASHIGI 256
Query: 291 SKISFTGSTTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNT 349
KI+FTGST GK++ A S +KRV++ELGG +P I+F A++D AV A F N
Sbjct: 257 DKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQ 316
Query: 350 GQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQV 409
GQ C ++ V+ I++ FV+ E K+ + VG+ F+ T QGP I++K K+ + +
Sbjct: 317 GQCCTAGSRIFVEESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELI 375
Query: 410 NDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAI 469
V++GA + GGK F EPT+ NVT DM EE FGP+ +++F T +E I
Sbjct: 376 QSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVI 435
Query: 470 AIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREG 529
AN +D GL ++ D + V+ ++ G V +N + + PFGG K SG GRE
Sbjct: 436 ERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREM 495
Query: 530 SKYGIDEYLELKYV 543
++G+ EY E+K V
Sbjct: 496 GEFGLREYSEVKTV 509
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 260 bits (664), Expect = 3e-69
Identities = 168/491 (34%), Positives = 267/491 (54%), Gaps = 28/491 (5%)
Query: 64 FVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWREVSAKE 119
F+ G++ A T+ +P G+ + V+ + + AV AA +AF W ++A+E
Sbjct: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
Query: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDI 178
R L+ + +L+ +N+++LA I +SG A I S +F+ ++ G
Sbjct: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
Query: 179 IH-TPAKDRRALVL--KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
I A+ R L K+P+GV A+I PWN+P M+ K A LAAG T+V+KPA+ TP
Sbjct: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPL 625
Query: 236 SALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISF 295
+AL AE L+ +AG P GV N+IP S A G+ + P + K+ F
Sbjct: 626 TALKFAE-------------LSVKAGFPKGVINIIPGSGGIA---GQRLSEHPDIRKLGF 669
Query: 296 TGSTTTGK-ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCV 354
TGST GK I+ A +++K+VS+ELGG +P I+F+ +D+AV M + F N G+ C+
Sbjct: 670 TGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCI 729
Query: 355 CSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVS 414
+ + V+ IHD FV E +KK +++G+ + T GP ++ +EK+ + V
Sbjct: 730 AAGRLFVEESIHDEFVTRVVEEIKK-MKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVK 788
Query: 415 KGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTE--EEAIAIA 472
+GAT+V GG++ Q F EPT+ +V M EE+FGP+ + KF + + A
Sbjct: 789 EGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRA 848
Query: 473 NAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKY 532
N+ + GLA +++D + V+E+LE G V +N + V PFGGVKQSG G++ +
Sbjct: 849 NSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEE 908
Query: 533 GIDEYLELKYV 543
++EYL+ K V
Sbjct: 909 ALNEYLKTKTV 919
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 259 bits (662), Expect = 4e-69
Identities = 160/479 (33%), Positives = 251/479 (52%), Gaps = 25/479 (5%)
Query: 72 AAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLM 131
A+ T +PA+G + G +E AV+ A AF W + S ER +L + ++
Sbjct: 49 ASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARII 108
Query: 132 IQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVL 191
+ +D++A + +GK + EA +I S LE+++ A + G+ I P
Sbjct: 109 REREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSF-GYTR 167
Query: 192 KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDL 251
++P+GV I WN+P + + K ALA G +V KP+ TP SAL LAE+
Sbjct: 168 REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIY------- 220
Query: 252 DPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN 311
S+AG+P G++NV+ + G+ +C P V+K+SFTGS TG ++ +A
Sbjct: 221 ------SEAGVPPGLFNVV----QGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 270
Query: 312 SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVK 371
+K V++ELGG +P I+F +++ AV GA+ + F GQ C + VQ+ I D F +
Sbjct: 271 GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 330
Query: 372 AFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH----- 426
+ ++ +++G+ E T GPLIN +E+V V A +GA V+ GG +
Sbjct: 331 EVVKQTQR-IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP 389
Query: 427 QLGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 485
+L ++ P +L N DM C EE FGP+ ++ FDTE E + AN GLA ++
Sbjct: 390 KLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFT 449
Query: 486 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 544
+D + RV +L+ G +N +S VE PFGG K+SG GRE + I+ Y +LK VC
Sbjct: 450 RDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 508
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 252 bits (644), Expect = 5e-67
Identities = 170/490 (34%), Positives = 253/490 (51%), Gaps = 25/490 (5%)
Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREV 115
T F+ W + + FPV +PA+ L V + + AV+AA +AF WR +
Sbjct: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80
Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174
A ER LL K +L+ +++ LA + + GK A+ L L + + A ++
Sbjct: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140
Query: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234
G I + +PIGV I PWNFP M+ K+G AL+ G TVVVKPAE TP
Sbjct: 141 QGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199
Query: 235 FSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKIS 294
+AL +A L +AG P GV N++P A G AI + + K++
Sbjct: 200 LTALHVAS-------------LIKEAGFPPGVVNIVPGYGPTA---GAAISSHMDIDKVA 243
Query: 295 FTGSTTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTC 353
FTGST GK++ A S +KRV++ELGG +P IV A++D AV A F + GQ C
Sbjct: 244 FTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCC 303
Query: 354 VCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAV 413
+ +++ V+ I+D FV+ E KK + +GN G TQGP I+++ +K+ +
Sbjct: 304 IAASRIFVEESIYDEFVRRSVERAKKYI-LGNPLTPGVTQGPQIDKEQYDKILDLIESGK 362
Query: 414 SKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIAN 473
+GA + GG F +PT+ NVT +M EE FGP+ ++KF + ++ I AN
Sbjct: 363 KEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRAN 422
Query: 474 AADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYG 533
GL+ +++D + ++ L+ G V VN + S +CPFGG K SG GRE +YG
Sbjct: 423 NTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYG 482
Query: 534 IDEYLELKYV 543
EY E+K V
Sbjct: 483 FHEYTEVKTV 492
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 251 bits (642), Expect = 9e-67
Identities = 170/491 (34%), Positives = 253/491 (51%), Gaps = 27/491 (5%)
Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
T F+ W + + F +P++ + V + + AV AA AF R WR +
Sbjct: 32 TKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRL 91
Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174
A R LL + +L+ +++ LA + T ++GKP A L L +F+ A ++
Sbjct: 92 DALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKI 151
Query: 175 YGDIIHTPAKDRRALVLK-QPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDT 233
G I P D + +PIGV ITPWNFP M+ K+ AL G T+V+KPAE T
Sbjct: 152 QGKTI--PTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQT 209
Query: 234 PFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKI 293
P +AL L L +AG P GV N++P VG AI + P ++KI
Sbjct: 210 PLTALYLGS-------------LIKEAGFPPGVVNIVPGF---GPTVGAAISSHPQINKI 253
Query: 294 SFTGSTTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQT 352
+FTGST GK++ A+ S +KRV++ELGG P IV A++D AV A F N GQ
Sbjct: 254 AFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQC 313
Query: 353 CVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDA 412
C +++ V+ ++ FV+ E KK VG+ F+ T QGP I++K +K+ + +
Sbjct: 314 CTAASRVFVEEQVYSEFVRRSVEYAKKR-PVGDPFDVKTEQGPQIDQKQFDKILELIESG 372
Query: 413 VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIA 472
+GA + GG + F +PT+ VT +M EE FGP+ P++KF + EE I A
Sbjct: 373 KKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRA 432
Query: 473 NAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKY 532
N+ D GL ++++ + ++A LE G V +N + PFGG K SG GRE +Y
Sbjct: 433 NSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEY 492
Query: 533 GIDEYLELKYV 543
+ EY E+K V
Sbjct: 493 ALAEYTEVKTV 503
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 249 bits (637), Expect = 4e-66
Identities = 170/487 (34%), Positives = 251/487 (51%), Gaps = 25/487 (5%)
Query: 64 FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREVSAK 118
F+ W A + TFP +P +G +G VA+ + AV+AA EAF WR + A
Sbjct: 40 FINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDAS 99
Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFL-EWFSEEARRVYGD 177
ER LL + +L+ +++ LA + T ++GKP +E++ L + +F+ A + +G
Sbjct: 100 ERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK 159
Query: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237
I + +P+GV I PWNFP M K+ ALA G TVV+K AE TP SA
Sbjct: 160 TIPMDGQ-HFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSA 218
Query: 238 LALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTG 297
L LA L +AG P GV N+I A G AI V K++FTG
Sbjct: 219 LYLAS-------------LIKEAGFPPGVVNIITGYGPTA---GAAIAQHVDVDKVAFTG 262
Query: 298 STTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCS 356
ST G ++ A +S +KRV++ELGG +P IV A+++ AV + F N GQ C
Sbjct: 263 STEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAG 322
Query: 357 NQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKG 416
++ V+ I++ F++ E K+ +VGN FE T QGP ++++ E+V + +G
Sbjct: 323 SRTFVEESIYNEFLERTVEKAKQR-KVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEG 381
Query: 417 ATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 476
A ++ GG+R F +PT+ V DM EE FGP+ P+ KF EE + AN
Sbjct: 382 AKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTR 441
Query: 477 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDE 536
GLA +++D + + L+ G V VN I + PFGG K+SG GRE + G+
Sbjct: 442 YGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKA 501
Query: 537 YLELKYV 543
Y E+K V
Sbjct: 502 YTEVKTV 508
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 248 bits (632), Expect = 1e-65
Identities = 167/487 (34%), Positives = 254/487 (52%), Gaps = 25/487 (5%)
Query: 64 FVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREVSAK 118
F+ W A + TFP +P++G + VA+ + AV+AA AF WR + A
Sbjct: 40 FINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDAS 99
Query: 119 ERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRVYGD 177
R LL + +L+ +++ LA + T ++GKP ++ L L +++ A + +G
Sbjct: 100 HRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK 159
Query: 178 IIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSA 237
I D + +P+GV I PWNFP M K+G ALA G VV+K AE TP +A
Sbjct: 160 TIPIDG-DFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTA 218
Query: 238 LALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTG 297
L +A L +AG P GV N++P A G AI + V K++FTG
Sbjct: 219 LYVAN-------------LIKEAGFPPGVVNIVPGFGPTA---GAAIASHEDVDKVAFTG 262
Query: 298 STTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCS 356
ST G+++ A +S +KRV++ELGG +P I+ A++D AV A + F N GQ C
Sbjct: 263 STEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAG 322
Query: 357 NQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKG 416
++ VQ I+D FV+ + A K+ VGN F+ T QGP ++E +K+ +N +G
Sbjct: 323 SRTFVQEDIYDEFVER-SVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEG 381
Query: 417 ATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAAD 476
A ++ GG F +PT+ +V M EE FGP+ ++KF T EE + AN +
Sbjct: 382 AKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNST 441
Query: 477 VGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDE 536
GLA +++D + +++ L+ G V VN + + PFGG K SG GRE +YG+
Sbjct: 442 YGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQA 501
Query: 537 YLELKYV 543
Y E+K V
Sbjct: 502 YTEVKTV 508
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 243 bits (621), Expect = 3e-64
Identities = 156/435 (35%), Positives = 227/435 (52%), Gaps = 28/435 (6%)
Query: 115 VSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSE 169
+ A ER LL K +L+ +++ LA + + GKP +A G I ++ W
Sbjct: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW--- 57
Query: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229
A +++G I D +PIGV I PWNFP M K+ AL G TVV+KP
Sbjct: 58 -ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKP 115
Query: 230 AEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL 289
AE TP SAL + L +AG P GV N++P A G AI +
Sbjct: 116 AEQTPLSALYMGA-------------LIKEAGFPPGVINILPGYGPTA---GAAIASHIG 159
Query: 290 VSKISFTGSTTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRN 348
+ KI+FTGST GK++ A S +KRV++ELGG +P I+F A++D AV A F N
Sbjct: 160 IDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFN 219
Query: 349 TGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQ 408
GQ C ++ V+ I++ FV+ E K+ + VG+ F+ T QGP I++K K+ +
Sbjct: 220 QGQCCTAGSRIFVEESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILEL 278
Query: 409 VNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEA 468
+ V++GA + GGK F EPT+ NVT DM EE FGP+ +++F T +E
Sbjct: 279 IQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEV 338
Query: 469 IAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGRE 528
I AN +D GL ++ D + V+ ++ G V +N + + PFGG K SG GRE
Sbjct: 339 IERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGRE 398
Query: 529 GSKYGIDEYLELKYV 543
++G+ EY E+K V
Sbjct: 399 MGEFGLREYSEVKTV 413
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 222 bits (566), Expect = 6e-58
Identities = 157/493 (31%), Positives = 234/493 (47%), Gaps = 69/493 (13%)
Query: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
T F+ W + + FPV +PA+G + V + + AV+AA AF WR +
Sbjct: 38 TKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRM 97
Query: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSEE 170
A ER LL K +L+ +++ LA + + GKP +A G I ++ W
Sbjct: 98 DASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW---- 153
Query: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230
A +++G I D +PIGV I PWNFP M K+ AL G TVV+KPA
Sbjct: 154 ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 212
Query: 231 EDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLV 290
E TP SAL + + KEVG+ I
Sbjct: 213 EQTPLSALYMGAL---------------------------------IKEVGKLI------ 233
Query: 291 SKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTG 350
G+ +++KRV++ELGG +P I+F A++D AV A F N G
Sbjct: 234 -------QEAAGR-------SNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQG 279
Query: 351 QTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVN 410
Q C ++ V+ I++ FV+ E K+ + VG+ F+ T QGP I++K K+ + +
Sbjct: 280 QCCTAGSRIFVEESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELIQ 338
Query: 411 DAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIA 470
V++GA + GGK F EPT+ NVT DM EE FGP+ +++F T +E I
Sbjct: 339 SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIE 398
Query: 471 IANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGS 530
AN +D GL ++ D + V+ ++ G V +N + + PFGG K SG GRE
Sbjct: 399 RANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMG 458
Query: 531 KYGIDEYLELKYV 543
++G+ EY E+K V
Sbjct: 459 EFGLREYSEVKTV 471
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 219 bits (559), Expect = 4e-57
Identities = 153/488 (31%), Positives = 242/488 (49%), Gaps = 65/488 (13%)
Query: 57 ALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116
ALL ++F+ G++LP ++ DP++G V + G E AAV+AA EAF W S
Sbjct: 6 ALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRS 65
Query: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175
+ERS +L + +L+ Q+ ++ A+ + + GK L A +I S +F+ +
Sbjct: 66 PQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHT 125
Query: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
+ ++ P+GVA +I+PWN P ++T K+ A+AAG TV+ KP+E T
Sbjct: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Query: 236 SALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISF 295
+A L + L +AG+P GV N++ VGEA+ + P V ISF
Sbjct: 186 TAWMLCK-------------LLDKAGVPPGVVNIV---FGTGPRVGEALVSHPEVPLISF 229
Query: 296 TGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVC 355
TGS T + + +A K++S+ELGG P I+F+ AN+D+ + + S F N ++ V
Sbjct: 230 TGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRSYV- 288
Query: 356 SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSK 415
+A AE + + G G V+K+
Sbjct: 289 --------------KRALAEGAQ--IWCGEG---------------VDKLSLPA------ 311
Query: 416 GATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAA 475
R+Q G F PT++ ++ + C EE FGP+ V+ FD+EEE I AN
Sbjct: 312 ---------RNQAG-YFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNV 361
Query: 476 DVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGID 535
GLA +S + ++ RVA++L+ G+V N LI + PFGG+K SG+GREG+K D
Sbjct: 362 KYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYD 421
Query: 536 EYLELKYV 543
+ E+K +
Sbjct: 422 FFTEIKTI 429
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 189 bits (480), Expect = 6e-48
Identities = 138/502 (27%), Positives = 231/502 (46%), Gaps = 30/502 (5%)
Query: 52 AGLSAALLRTDSFVGGRWLPAAAT--FPVQDPASGAALGMVADCGVREARAAVRAAYEAF 109
+ S+++ F+GG+++ + + + +PA+ +G V E AA+ + AF
Sbjct: 31 SSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAF 90
Query: 110 CRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSE 169
W + S R +L ++ L+ +N ++A++IT E GK L +A G++ +E
Sbjct: 91 PAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACS 150
Query: 170 EARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKP 229
+ G+ + + KD + P+GV A I P+NFP+ + A+ G T ++KP
Sbjct: 151 VTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKP 210
Query: 230 AEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL 289
+E P + + LA+ L +G P G N+I E IC P
Sbjct: 211 SERVPGATMLLAK-------------LLQDSGAPDGTLNII----HGQHEAVNFICDHPD 253
Query: 290 VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNT 349
+ ISF GS G+ + + KRV +G +V AN + + + + F
Sbjct: 254 IKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAA 313
Query: 350 GQTCVC-SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQ 408
GQ C+ S LV G ++ E KNLRV G + G GPLI +A E+V
Sbjct: 314 GQRCMALSTAVLV--GEAKKWLPELVE-HAKNLRVNAGDQPGADLGPLITPQAKERVCNL 370
Query: 409 VNDAVSKGATVVTGGKRHQL----GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDT 464
++ +GA+++ G++ ++ NF PT++ NV +M C EE FGP+ V++ +T
Sbjct: 371 IDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETET 430
Query: 465 EEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL-ISSVECPFGGVKQS 523
+EAI I N G ++ + A + A ++VG VGVN + + F G + S
Sbjct: 431 LDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSS 490
Query: 524 GLGREG--SKYGIDEYLELKYV 543
G K GI Y +LK +
Sbjct: 491 FRGDTNFYGKQGIQFYTQLKTI 512
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 175 bits (443), Expect = 1e-43
Identities = 136/511 (26%), Positives = 223/511 (43%), Gaps = 19/511 (3%)
Query: 33 PASGPAPGPAQLRCYAGRLAGLSAALLRTDS--FVGGRWLPAAATFPVQDPASGAALGMV 90
P S PA + L + A L LR ++ G W PA+ + V
Sbjct: 21 PWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWGGRGEVITTYCPANNEPIARV 80
Query: 91 ADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPL 150
V + V+ A EA+ W ++ A +R ++R+ + + + L +++ E GK L
Sbjct: 81 RQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGKIL 140
Query: 151 KEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAM 210
E GE+ ++ +R + G I+ + + P+G+ +IT +NFP A+
Sbjct: 141 VEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAV 200
Query: 211 ITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVI 270
A+ G + K A T ++A+ ++ L D +P + + +
Sbjct: 201 YGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNK---------LPGAICS-L 250
Query: 271 PCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFD 330
C ++G A+ D V+ +SFTGST GK + R +ELGG I F+
Sbjct: 251 TCG---GADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFE 307
Query: 331 SANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEG 390
A++ V A+ + GQ C + + + IHD V +A + +RVGN ++
Sbjct: 308 DADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQ-IRVGNPWDPN 366
Query: 391 TTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHE 450
GPL ++AV V +A +G TVV GGK N+ EPT++ + D H
Sbjct: 367 VLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHT 426
Query: 451 ETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQI--WRVAEQLEVGMVGVNEG 508
ETF P+ V KF EEE A N GL+ +++D +I W + + G+V VN
Sbjct: 427 ETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIP 486
Query: 509 LI-SSVECPFGGVKQSGLGREGSKYGIDEYL 538
+ + FGG K +G GRE +Y+
Sbjct: 487 TSGAEIGGAFGGEKHTGGGRESGSDAWKQYM 517
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 137 bits (345), Expect = 3e-32
Identities = 134/521 (25%), Positives = 220/521 (42%), Gaps = 45/521 (8%)
Query: 23 RLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAA--TFPVQD 80
R PRA + + P P C LA L +V G+WL + P QD
Sbjct: 5 RAGPRAREIFTSLEYGPVPESHAC---ALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQD 61
Query: 81 PASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLAR 140
P +G L + AAV AA AF W R+ L + ++ +++ L
Sbjct: 62 PITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWT 121
Query: 141 IITAESGKPLKEAH-GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAA 199
+ + +G+ ++E G++ + L + + +A + AL +P+GV
Sbjct: 122 LESLVTGRAVREVRDGDVQLAQQLLHYHAIQA-----------STQEEALAGWEPMGVIG 170
Query: 200 VITPWNFPSAMITRKVGAALAAGCTVV--VKPAEDTPFSALALAEVNQGFLLDLDPLLLA 257
+I P F + ++ ALA GCTVV V PA P L LA+ LA
Sbjct: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---LLLAQ-------------LA 214
Query: 258 SQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVS 317
+ G G+ NV+ + + + P + K++F G+ G+ L A +
Sbjct: 215 GELGPFPGILNVL----SGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAELG 270
Query: 318 MELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAM 377
+ LG + ++ D+A+VD AV G + + + + G + + L+Q + D ++ E M
Sbjct: 271 LALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGL---RLLIQESVWDEAMRRLQERM 327
Query: 378 KKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTL 437
+ LR G G + G A + V++ V +A S+GA V G + F+ PTL
Sbjct: 328 GR-LRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPS-ERPFYPPTL 384
Query: 438 LCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQ 497
+ N+ C E P+ F T +EA+ +AN G + +S+ Q +
Sbjct: 385 VSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYG 444
Query: 498 LEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYL 538
L+VG V +N + P GG K+SG G G+ EYL
Sbjct: 445 LQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYL 485
Score = 73.6 bits (179), Expect = 4e-13
Identities = 73/262 (27%), Positives = 112/262 (42%), Gaps = 27/262 (10%)
Query: 5 IWLRSCGARRL-----GSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALL 59
+W+ + G R G GC GL P+ PA+L C + L + L
Sbjct: 450 VWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLA 509
Query: 60 RTDS-----------------FVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARA 100
+ FVGGR+ A ++ P++D +SG G VA+ G ++ R
Sbjct: 510 VPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGGAKDIRG 568
Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS 160
AV AA++AF W S R++LL + + K LA + + G LK A E+ S
Sbjct: 569 AVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQ-GAELKAAEAEVELS 627
Query: 161 AFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALA 220
A L + + G + L L++P+GV AV+ P +P + ALA
Sbjct: 628 ARRLRAWGARVQ-AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALA 686
Query: 221 AGCTVVVKPAEDTPFSALALAE 242
G TVV+ P+ P AL + +
Sbjct: 687 YGNTVVMVPSAACPLLALEVCQ 708
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 134 bits (337), Expect = 2e-31
Identities = 123/446 (27%), Positives = 203/446 (45%), Gaps = 39/446 (8%)
Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159
AV+ A AF R + R L L+ + + +L + A+ K A+ E++Y
Sbjct: 7 AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 66
Query: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVL-KQPIGVAAVITPWNFPSAMITRKVG 216
+E+ ++ D + TP + L + +P+GV VI WN+P + + +
Sbjct: 67 VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126
Query: 217 AALAAGCTVVVKPAEDTPFSALALAEVNQGFL-LDLDPLLLASQAGIPSGVYNVIPCSRK 275
A+AAG +VV+KP+E + A LA + +L DL P++ G+P + +
Sbjct: 127 GAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVI---NGGVPE--------TTE 175
Query: 276 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVD 335
KE I +TGST GKI++ AA + V++ELGG +P V + ++D
Sbjct: 176 LLKE---------RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLD 226
Query: 336 QAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQ 393
A KF N+GQTCV + L I + V E +KK+L+ G ++
Sbjct: 227 VACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDY 282
Query: 394 GPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETF 453
G +I+ + ++V + +G V GG + PT+L +V EE F
Sbjct: 283 GRIISARHFQRVM-----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIF 336
Query: 454 GPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--IS 511
GP+ P++ + EEAI N + LA Y +S + I ++ + G V N+ + I+
Sbjct: 337 GPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHIT 396
Query: 512 SVECPFGGVKQSGLGREGSKYGIDEY 537
PFGGV SG+G K + +
Sbjct: 397 LHSLPFGGVGNSGMGSYHGKKSFETF 422
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 134 bits (337), Expect = 2e-31
Identities = 123/446 (27%), Positives = 203/446 (45%), Gaps = 39/446 (8%)
Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159
AV+ A AF R + R L L+ + + +L + A+ K A+ E++Y
Sbjct: 7 AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 66
Query: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVL-KQPIGVAAVITPWNFPSAMITRKVG 216
+E+ ++ D + TP + L + +P+GV VI WN+P + + +
Sbjct: 67 VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126
Query: 217 AALAAGCTVVVKPAEDTPFSALALAEVNQGFL-LDLDPLLLASQAGIPSGVYNVIPCSRK 275
A+AAG +VV+KP+E + A LA + +L DL P++ G+P + +
Sbjct: 127 GAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVI---NGGVPE--------TTE 175
Query: 276 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVD 335
KE I +TGST GKI++ AA + V++ELGG +P V + ++D
Sbjct: 176 LLKE---------RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLD 226
Query: 336 QAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQ 393
A KF N+GQTCV + L I + V E +KK+L+ G ++
Sbjct: 227 VACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDY 282
Query: 394 GPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETF 453
G +I+ + ++V + +G V GG + PT+L +V EE F
Sbjct: 283 GRIISARHFQRVM-----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIF 336
Query: 454 GPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--IS 511
GP+ P++ + EEAI N + LA Y +S + I ++ + G V N+ + I+
Sbjct: 337 GPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHIT 396
Query: 512 SVECPFGGVKQSGLGREGSKYGIDEY 537
PFGGV SG+G K + +
Sbjct: 397 LHSLPFGGVGNSGMGSYHGKKSFETF 422
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 134 bits (337), Expect = 2e-31
Identities = 123/446 (27%), Positives = 203/446 (45%), Gaps = 39/446 (8%)
Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159
AV+ A AF R + R L L+ + + +L + A+ K A+ E++Y
Sbjct: 7 AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 66
Query: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVL-KQPIGVAAVITPWNFPSAMITRKVG 216
+E+ ++ D + TP + L + +P+GV VI WN+P + + +
Sbjct: 67 VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126
Query: 217 AALAAGCTVVVKPAEDTPFSALALAEVNQGFL-LDLDPLLLASQAGIPSGVYNVIPCSRK 275
A+AAG +VV+KP+E + A LA + +L DL P++ G+P + +
Sbjct: 127 GAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVI---NGGVPE--------TTE 175
Query: 276 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVD 335
KE I +TGST GKI++ AA + V++ELGG +P V + ++D
Sbjct: 176 LLKE---------RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLD 226
Query: 336 QAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQ 393
A KF N+GQTCV + L I + V E +KK+L+ G ++
Sbjct: 227 VACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDY 282
Query: 394 GPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETF 453
G +I+ + ++V + +G V GG + PT+L +V EE F
Sbjct: 283 GRIISARHFQRVM-----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIF 336
Query: 454 GPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--IS 511
GP+ P++ + EEAI N + LA Y +S + I ++ + G V N+ + I+
Sbjct: 337 GPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHIT 396
Query: 512 SVECPFGGVKQSGLGREGSKYGIDEY 537
PFGGV SG+G K + +
Sbjct: 397 LHSLPFGGVGNSGMGSYHGKKSFETF 422
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 134 bits (336), Expect = 3e-31
Identities = 104/351 (29%), Positives = 167/351 (47%), Gaps = 31/351 (8%)
Query: 190 VLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLL 249
+ K+P G+ +I PWN+P + + ALAAG VV+KP+E + + LAEV +L
Sbjct: 19 IWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQYL- 77
Query: 250 DLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 309
D A G P +E G+ + + + I FTGS GKI++ A
Sbjct: 78 --DQSCFAVVLGGP--------------QETGQLL--EHKLDYIFFTGSPRVGKIVMTAA 119
Query: 310 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIHDA 368
+ V++ELGG P V D+ + Q VA +A + N GQTCV + L + +
Sbjct: 120 TKHLTPVTLELGGKNPCYVDDNCD-PQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQER 178
Query: 369 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL 428
+ A + + G+ + G +IN+K +++ A+ V GG+ ++
Sbjct: 179 LLPALQSTITRFY--GDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSNES 231
Query: 429 GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDP 488
+ + PT+L +V + EE FGP+ P++ + +EAI N + LA Y +S
Sbjct: 232 DR-YIAPTVLVDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSS 290
Query: 489 AQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 537
+ ++ E+ G G NEG IS + PFGGV SG+GR K+ D +
Sbjct: 291 QVVNQMLERTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTF 341
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 134 bits (336), Expect = 3e-31
Identities = 104/351 (29%), Positives = 167/351 (47%), Gaps = 31/351 (8%)
Query: 190 VLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLL 249
+ K+P G+ +I PWN+P + + ALAAG VV+KP+E + + LAEV +L
Sbjct: 19 IWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQYL- 77
Query: 250 DLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHA 309
D A G P +E G+ + + + I FTGS GKI++ A
Sbjct: 78 --DQSCFAVVLGGP--------------QETGQLL--EHKLDYIFFTGSPRVGKIVMTAA 119
Query: 310 ANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIHDA 368
+ V++ELGG P V D+ + Q VA +A + N GQTCV + L + +
Sbjct: 120 TKHLTPVTLELGGKNPCYVDDNCD-PQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQER 178
Query: 369 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQL 428
+ A + + G+ + G +IN+K +++ A+ V GG+ ++
Sbjct: 179 LLPALQSTITRFY--GDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSNES 231
Query: 429 GKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDP 488
+ + PT+L +V + EE FGP+ P++ + +EAI N + LA Y +S
Sbjct: 232 DR-YIAPTVLVDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSS 290
Query: 489 AQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 537
+ ++ E+ G G NEG IS + PFGGV SG+GR K+ D +
Sbjct: 291 QVVNQMLERTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTF 341
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 128 bits (322), Expect = 1e-29
Identities = 104/362 (28%), Positives = 166/362 (45%), Gaps = 31/362 (8%)
Query: 179 IHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSAL 238
+H + A + K+P G+ +I PWN+P + + ALAAG VV+KP+E +
Sbjct: 52 LHKATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEK 111
Query: 239 ALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGS 298
LAEV + +D A G P +E G+ + + I FTGS
Sbjct: 112 ILAEVLPQY---VDQSCFAVVLGGP--------------QETGQLL--EHRFDYIFFTGS 152
Query: 299 TTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSN 357
GKI++ AA + V++ELGG P V D+ + Q VA +A ++ N GQTCV +
Sbjct: 153 PRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPD 211
Query: 358 QFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGA 417
L + + + A + + G+ + G +IN+K +++ A+
Sbjct: 212 YVLCSPEMQERLLPALQSTITR--FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCG 264
Query: 418 TVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADV 477
V GG+ + + PT+L +V + EE FGP+ P++ + +EAI N +
Sbjct: 265 RVAIGGQSDE-SDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323
Query: 478 GLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGID 535
LA Y +S + RV Q G N+G ++ PFGGV SG+GR K+ D
Sbjct: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383
Query: 536 EY 537
+
Sbjct: 384 TF 385
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 127 bits (320), Expect = 2e-29
Identities = 103/353 (29%), Positives = 163/353 (46%), Gaps = 31/353 (8%)
Query: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGF 247
A + K+P G+ +I PWN+P + + ALAAG VV+KP+E + LAEV +
Sbjct: 98 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157
Query: 248 LLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 307
+D A G P +E G+ + + I FTGS GKI++
Sbjct: 158 ---VDQSCFAVVLGGP--------------QETGQLL--EHRFDYIFFTGSPRVGKIVMT 198
Query: 308 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIH 366
AA + V++ELGG P V D+ + Q VA +A ++ N GQTCV + L +
Sbjct: 199 AAAKHLTPVTLELGGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQ 257
Query: 367 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 426
+ + A + + G+ + G +IN+K +++ A+ V GG+
Sbjct: 258 ERLLPALQSTITR--FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSD 310
Query: 427 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 486
+ + PT+L +V + EE FGP+ P++ + +EAI N + LA Y +S
Sbjct: 311 E-SDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSN 369
Query: 487 DPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 537
+ RV Q G N+G ++ PFGGV SG+GR K+ D +
Sbjct: 370 SSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 127 bits (320), Expect = 2e-29
Identities = 103/353 (29%), Positives = 163/353 (46%), Gaps = 31/353 (8%)
Query: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGF 247
A + K+P G+ +I PWN+P + + ALAAG VV+KP+E + LAEV +
Sbjct: 98 AFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY 157
Query: 248 LLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 307
+D A G P +E G+ + + I FTGS GKI++
Sbjct: 158 ---VDQSCFAVVLGGP--------------QETGQLL--EHRFDYIFFTGSPRVGKIVMT 198
Query: 308 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMA-SKFRNTGQTCVCSNQFLVQRGIH 366
AA + V++ELGG P V D+ + Q VA +A ++ N GQTCV + L +
Sbjct: 199 AAAKHLTPVTLELGGKNPCYVDDNCD-PQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQ 257
Query: 367 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 426
+ + A + + G+ + G +IN+K +++ A+ V GG+
Sbjct: 258 ERLLPALQSTITR--FYGDDPQSSPNLGRIINQKQFQRLR-----ALLGCGRVAIGGQSD 310
Query: 427 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 486
+ + PT+L +V + EE FGP+ P++ + +EAI N + LA Y +S
Sbjct: 311 E-SDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSN 369
Query: 487 DPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGLGREGSKYGIDEY 537
+ RV Q G N+G ++ PFGGV SG+GR K+ D +
Sbjct: 370 SSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 125 bits (313), Expect = 1e-28
Identities = 92/352 (26%), Positives = 162/352 (46%), Gaps = 29/352 (8%)
Query: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGF 247
A + QP+GV +I WN+P + + + A+AAG V++KP+E + +A LA++ +
Sbjct: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154
Query: 248 LLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 307
L D D ++ I GV ++ I +TG+T GKI++
Sbjct: 155 L-DQDLYIV-----INGGVEETTELLKQR-------------FDHIFYTGNTAVGKIVME 195
Query: 308 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 367
AA + V++ELGG +P + ++D K+ N GQTC+ + L + + +
Sbjct: 196 AAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN 255
Query: 368 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 427
V E +K+ G +E +IN + +++ ++ +G + GG+ +
Sbjct: 256 QIVWKIKETVKE--FYGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE 308
Query: 428 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 487
+ PT+L +V EE FGP+ P++ +EAI N + LA Y +S +
Sbjct: 309 -ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHN 367
Query: 488 PAQIWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEY 537
I R+ ++ G V N+ ++ PFGGV SG+G K+ D +
Sbjct: 368 HKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 125 bits (313), Expect = 1e-28
Identities = 92/352 (26%), Positives = 162/352 (46%), Gaps = 29/352 (8%)
Query: 188 ALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGF 247
A + QP+GV +I WN+P + + + A+AAG V++KP+E + +A LA++ +
Sbjct: 95 AYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY 154
Query: 248 LLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 307
L D D ++ I GV ++ I +TG+T GKI++
Sbjct: 155 L-DQDLYIV-----INGGVEETTELLKQR-------------FDHIFYTGNTAVGKIVME 195
Query: 308 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 367
AA + V++ELGG +P + ++D K+ N GQTC+ + L + + +
Sbjct: 196 AAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQN 255
Query: 368 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 427
V E +K+ G +E +IN + +++ ++ +G + GG+ +
Sbjct: 256 QIVWKIKETVKE--FYGENIKESPDYERIINLRHFKRIL-----SLLEGQKIAFGGETDE 308
Query: 428 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQD 487
+ PT+L +V EE FGP+ P++ +EAI N + LA Y +S +
Sbjct: 309 -ATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHN 367
Query: 488 PAQIWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGIDEY 537
I R+ ++ G V N+ ++ PFGGV SG+G K+ D +
Sbjct: 368 HKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 100 bits (250), Expect = 3e-21
Identities = 124/521 (23%), Positives = 197/521 (37%), Gaps = 96/521 (18%)
Query: 23 RLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAA--TFPVQD 80
R PRA + + P P C LA L +V G+WL + P QD
Sbjct: 5 RAGPRAREIFTSLEYGPVPESHAC---ALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQD 61
Query: 81 PASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLAR 140
P +G L + AAV AA AF W R+ L + ++ +++ L
Sbjct: 62 PITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWT 121
Query: 141 IITAESGKPLKEAH-GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAA 199
+ + +G+ ++E G++ + L + + +A + AL +P+GV
Sbjct: 122 LESLVTGRAVREVRDGDVQLAQQLLHYHAIQA-----------STQEEALAGWEPMGVIG 170
Query: 200 VITPWNFPSAMITRKVGAALAAGCTVV--VKPAEDTPFSALALAEVNQGFLLDLDPLLLA 257
+I P F + ++ ALA GCTVV V PA P L LA+ LA
Sbjct: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---LLLAQ-------------LA 214
Query: 258 SQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVS 317
+ G G+ NV+ + + + P + K++F G+
Sbjct: 215 GELGPFPGILNVL----SGPASLVPILASQPGIRKVAFCGAPE----------------- 253
Query: 318 MELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAM 377
GGL + L+Q + D ++ E M
Sbjct: 254 ---GGL----------------------------------RLLIQESVWDEAMRRLQERM 276
Query: 378 KKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTL 437
+ LR G G + G A + V++ V +A S+GA V G + F+ PTL
Sbjct: 277 GR-LRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPS-ERPFYPPTL 333
Query: 438 LCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQ 497
+ N+ C E P+ F T +EA+ +AN G + +S+ Q +
Sbjct: 334 VSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYG 393
Query: 498 LEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYL 538
L+VG V +N + P GG K+SG G G+ EYL
Sbjct: 394 LQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYL 434
Score = 73.6 bits (179), Expect = 4e-13
Identities = 73/262 (27%), Positives = 112/262 (42%), Gaps = 27/262 (10%)
Query: 5 IWLRSCGARRL-----GSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALL 59
+W+ + G R G GC GL P+ PA+L C + L + L
Sbjct: 399 VWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLA 458
Query: 60 RTDS-----------------FVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARA 100
+ FVGGR+ A ++ P++D +SG G VA+ G ++ R
Sbjct: 459 VPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGGAKDIRG 517
Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS 160
AV AA++AF W S R++LL + + K LA + + G LK A E+ S
Sbjct: 518 AVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQ-GAELKAAEAEVELS 576
Query: 161 AFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALA 220
A L + + G + L L++P+GV AV+ P +P + ALA
Sbjct: 577 ARRLRAWGARVQ-AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALA 635
Query: 221 AGCTVVVKPAEDTPFSALALAE 242
G TVV+ P+ P AL + +
Sbjct: 636 YGNTVVMVPSAACPLLALEVCQ 657
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 89.4 bits (220), Expect = 8e-18
Identities = 105/444 (23%), Positives = 193/444 (43%), Gaps = 41/444 (9%)
Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNKDDLARIITAESGKPLKEAHGEIL 158
A+ AA A W +R+ + K +++ + + LA+ + + GK + +A EI
Sbjct: 105 AIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EID 161
Query: 159 YSAFFLEWFSEEAR---RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKV 215
+A +++F A+ + G + + V + G A I+P+NF +A+
Sbjct: 162 AAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLA 220
Query: 216 GAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRK 275
GA G V+ KP++ ++ A+ + + +AG+P + +P
Sbjct: 221 GAPALMGNVVLWKPSDTAMLASYAVYRILR-------------EAGLPPNIIQFVPA--- 264
Query: 276 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVF 329
+ G+ + + + I+FTGS T K L A ++ R ++ E GG V
Sbjct: 265 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 324
Query: 330 DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE 389
SA+V+ V+G + S F GQ C ++ V + E + ++VG+ E+
Sbjct: 325 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSR-IKVGDPAED 383
Query: 390 -GTTQGPLINEKAVEKVEKQVNDA-VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLC 447
GT +I+ K+ +++K + A S T++ GGK F EP ++ +
Sbjct: 384 FGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPI 443
Query: 448 THEETFGPLAPVIKF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGM 502
EE FGP+ V + D +E + + ++ GL G +SQD + + L G
Sbjct: 444 MKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGN 503
Query: 503 VGVNEGLISSV--ECPFGGVKQSG 524
+N+ S+ + PFGG + SG
Sbjct: 504 FYINDKSTGSIVGQQPFGGARASG 527
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 89.4 bits (220), Expect = 8e-18
Identities = 105/444 (23%), Positives = 193/444 (43%), Gaps = 41/444 (9%)
Query: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNKDDLARIITAESGKPLKEAHGEIL 158
A+ AA A W +R+ + K +++ + + LA+ + + GK + +A EI
Sbjct: 45 AIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EID 101
Query: 159 YSAFFLEWFSEEAR---RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKV 215
+A +++F A+ + G + + V + G A I+P+NF +A+
Sbjct: 102 AAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLA 160
Query: 216 GAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRK 275
GA G V+ KP++ ++ A+ + + +AG+P + +P
Sbjct: 161 GAPALMGNVVLWKPSDTAMLASYAVYRILR-------------EAGLPPNIIQFVPA--- 204
Query: 276 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVF 329
+ G+ + + + I+FTGS T K L A ++ R ++ E GG V
Sbjct: 205 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 264
Query: 330 DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE 389
SA+V+ V+G + S F GQ C ++ V + E + ++VG+ E+
Sbjct: 265 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSR-IKVGDPAED 323
Query: 390 -GTTQGPLINEKAVEKVEKQVNDA-VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLC 447
GT +I+ K+ +++K + A S T++ GGK F EP ++ +
Sbjct: 324 FGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPI 383
Query: 448 THEETFGPLAPVIKF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGM 502
EE FGP+ V + D +E + + ++ GL G +SQD + + L G
Sbjct: 384 MKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGN 443
Query: 503 VGVNEGLISSV--ECPFGGVKQSG 524
+N+ S+ + PFGG + SG
Sbjct: 444 FYINDKSTGSIVGQQPFGGARASG 467
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,302,806
Number of Sequences: 37866
Number of extensions: 898027
Number of successful extensions: 2580
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2421
Number of HSP's gapped (non-prelim): 56
length of query: 548
length of database: 18,247,518
effective HSP length: 107
effective length of query: 441
effective length of database: 14,195,856
effective search space: 6260372496
effective search space used: 6260372496
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.