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Search of human proteins with 25777626
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25777626 ankyrin repeat and BTB (POZ) domain containing 1
isoform 3 [Homo sapiens]
(453 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25777626 ankyrin repeat and BTB (POZ) domain containing 1 iso... 937 0.0
gi|25777624 ankyrin repeat and BTB (POZ) domain containing 1 iso... 900 0.0
gi|14211841 ankyrin repeat and BTB (POZ) domain containing 1 iso... 686 0.0
gi|40018614 DRE1 protein [Homo sapiens] 68 1e-11
gi|24432026 kelch-like [Homo sapiens] 67 4e-11
gi|56117834 speckle-type POZ protein [Homo sapiens] 66 6e-11
gi|56117832 speckle-type POZ protein [Homo sapiens] 66 6e-11
gi|56117830 speckle-type POZ protein [Homo sapiens] 66 6e-11
gi|56117828 speckle-type POZ protein [Homo sapiens] 66 6e-11
gi|4507183 speckle-type POZ protein [Homo sapiens] 66 6e-11
gi|56117836 speckle-type POZ protein [Homo sapiens] 66 6e-11
gi|224465242 BTB (POZ) domain containing 8 [Homo sapiens] 65 1e-10
gi|8922528 kelch-like 11 [Homo sapiens] 65 1e-10
gi|148664209 kelch-like 10 [Homo sapiens] 62 8e-10
gi|40255071 kelch-like 23 [Homo sapiens] 62 1e-09
gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens] 62 1e-09
gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens] 62 1e-09
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens] 61 2e-09
gi|55925608 kelch-like 21 [Homo sapiens] 60 5e-09
gi|211904190 hypothetical protein LOC149478 [Homo sapiens] 59 9e-09
gi|156616301 kelch-like 32 [Homo sapiens] 59 9e-09
gi|48717263 speckle-type POZ protein-like [Homo sapiens] 59 1e-08
gi|8922854 kelch-like 26 [Homo sapiens] 59 1e-08
gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo... 58 2e-08
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 57 3e-08
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 57 3e-08
gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isof... 57 4e-08
gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isof... 57 4e-08
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 56 6e-08
gi|109150407 kelch-like 6 [Homo sapiens] 56 8e-08
>gi|25777626 ankyrin repeat and BTB (POZ) domain containing 1
isoform 3 [Homo sapiens]
Length = 453
Score = 937 bits (2422), Expect = 0.0
Identities = 453/453 (100%), Positives = 453/453 (100%)
Query: 1 MWAECGTCWSSETWRYYACLCGHEELVLYLLANGARCEANTFDGERCLYGALSDPIRRAL 60
MWAECGTCWSSETWRYYACLCGHEELVLYLLANGARCEANTFDGERCLYGALSDPIRRAL
Sbjct: 1 MWAECGTCWSSETWRYYACLCGHEELVLYLLANGARCEANTFDGERCLYGALSDPIRRAL 60
Query: 61 RDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLD 120
RDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLD
Sbjct: 61 RDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLD 120
Query: 121 TKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLE 180
TKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLE
Sbjct: 121 TKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLE 180
Query: 181 AKCEKVSEFVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELRGDLWELPFPCP 240
AKCEKVSEFVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELRGDLWELPFPCP
Sbjct: 181 AKCEKVSEFVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELRGDLWELPFPCP 240
Query: 241 DGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGI 300
DGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGI
Sbjct: 241 DGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGI 300
Query: 301 SPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVW 360
SPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVW
Sbjct: 301 SPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVW 360
Query: 361 RVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRF 420
RVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRF
Sbjct: 361 RVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRF 420
Query: 421 HVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC 453
HVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC
Sbjct: 421 HVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC 453
>gi|25777624 ankyrin repeat and BTB (POZ) domain containing 1
isoform 2 [Homo sapiens]
Length = 478
Score = 900 bits (2325), Expect = 0.0
Identities = 441/445 (99%), Positives = 441/445 (99%), Gaps = 1/445 (0%)
Query: 9 WSSETWRYYACLCGHEELVLYLLANGARCEANTFDGERCLYGALSDPIRRALRDYKQVTA 68
W S T YYACLCGHEELVLYLLANGARCEANTFDGERCLYGALSDPIRRALRDYKQVTA
Sbjct: 35 WDS-TPLYYACLCGHEELVLYLLANGARCEANTFDGERCLYGALSDPIRRALRDYKQVTA 93
Query: 69 SCRRRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSV 128
SCRRRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSV
Sbjct: 94 SCRRRDYYDDFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSV 153
Query: 129 VVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSE 188
VVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSE
Sbjct: 154 VVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSE 213
Query: 189 FVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPD 248
FVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPD
Sbjct: 214 FVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELRGDLWELPFPCPDGFNSCPD 273
Query: 249 ICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHV 308
ICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHV
Sbjct: 274 ICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHV 333
Query: 309 LYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRL 368
LYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRL
Sbjct: 334 LYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRL 393
Query: 369 ARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQT 428
ARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQT
Sbjct: 394 ARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQT 453
Query: 429 YSAIEEAQQRLRALEDLLVSIGLDC 453
YSAIEEAQQRLRALEDLLVSIGLDC
Sbjct: 454 YSAIEEAQQRLRALEDLLVSIGLDC 478
>gi|14211841 ankyrin repeat and BTB (POZ) domain containing 1
isoform 1 [Homo sapiens]
Length = 336
Score = 686 bits (1771), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 118 MLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLS 177
MLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLS
Sbjct: 1 MLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLS 60
Query: 178 DLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELRGDLWELPF 237
DLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELRGDLWELPF
Sbjct: 61 DLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLREDMALLADCALPPELRGDLWELPF 120
Query: 238 PCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTL 297
PCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTL
Sbjct: 121 PCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTL 180
Query: 298 HGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVV 357
HGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVV
Sbjct: 181 HGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVV 240
Query: 358 GVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDD 417
GVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDD
Sbjct: 241 GVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDD 300
Query: 418 IRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC 453
IRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC
Sbjct: 301 IRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC 336
Score = 31.6 bits (70), Expect = 1.5
Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 11/81 (13%)
Query: 91 DVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWK---------GKSVVVLRHPLINPVAF 141
D+ F V G F H+ RS YF +LD ++ G V L I+P F
Sbjct: 131 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHG--ISPDVF 188
Query: 142 GALLQYLYTGRLDIGVEHVSD 162
+L Y+Y+ ++ E D
Sbjct: 189 THVLYYMYSDHTELSPEAAYD 209
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 68.2 bits (165), Expect = 1e-11
Identities = 40/152 (26%), Positives = 70/152 (46%), Gaps = 7/152 (4%)
Query: 248 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTH 307
D+ V G F CH+A S YFRA+ + RES E V ++GI +
Sbjct: 67 DVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREML-------VEINGILAEAMEC 119
Query: 308 VLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFR 367
L Y+Y+ +++ E + + ++ + L+ C + L + LD +G+ R A
Sbjct: 120 FLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHS 179
Query: 368 LARLEDQCTEYMAKVIEKLVEREDFVEAVKEE 399
L L +C + + E + + E+F+E K+E
Sbjct: 180 LKTLFTKCKNFALQTFEDVSQHEEFLELDKDE 211
Score = 45.8 bits (107), Expect = 8e-05
Identities = 26/73 (35%), Positives = 38/73 (52%)
Query: 88 IHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQY 147
+ +DV+ V GK F HR VL A S+YF M + +++ I A LQY
Sbjct: 64 LFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQY 123
Query: 148 LYTGRLDIGVEHV 160
+YTG++ I E+V
Sbjct: 124 VYTGKVKITTENV 136
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 66.6 bits (161), Expect = 4e-11
Identities = 37/134 (27%), Positives = 63/134 (47%), Gaps = 7/134 (5%)
Query: 248 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTH 307
D+ V G H+ DYFR + +E E+ V +HG+S +
Sbjct: 51 DVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEE-------VLIHGVSYNAMCQ 103
Query: 308 VLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFR 367
+L+++Y+ ELS + L A +P + C L +DE+ ++ V+R+A+LF
Sbjct: 104 ILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFD 163
Query: 368 LARLEDQCTEYMAK 381
L+RL +Q Y+ K
Sbjct: 164 LSRLTEQLDTYILK 177
Score = 44.7 bits (104), Expect = 2e-04
Identities = 32/96 (33%), Positives = 46/96 (47%), Gaps = 8/96 (8%)
Query: 80 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPV 139
L L + GI DVV VV G+ HR +L A YF M G + LI+ V
Sbjct: 40 LLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFA---GGLKEMEQEEVLIHGV 96
Query: 140 AFGA---LLQYLYTGRLDIGVEHVSDCERLAKQCQL 172
++ A +L ++YT L++ + +V E L CQL
Sbjct: 97 SYNAMCQILHFIYTSELELSLSNVQ--ETLVAACQL 130
>gi|56117834 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 66.2 bits (160), Expect = 6e-11
Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 16/165 (9%)
Query: 215 DMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRA 274
+M + +C L EL G LWE F C C VAG F HKA RS F A
Sbjct: 177 NMVKVPECRLADEL-GGLWE-----NSRFTDC---CLCVAGQEFQAHKAILAARSPVFSA 227
Query: 275 LLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMY 334
+ + ES++ V ++ + P+VF ++ ++Y+ + A D+L+ AD Y
Sbjct: 228 MFEHEMEESKKNR-------VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKY 280
Query: 335 LLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYM 379
L LK +C +L L + + +A L +L+ Q +++
Sbjct: 281 ALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|56117832 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 66.2 bits (160), Expect = 6e-11
Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 16/165 (9%)
Query: 215 DMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRA 274
+M + +C L EL G LWE F C C VAG F HKA RS F A
Sbjct: 177 NMVKVPECRLADEL-GGLWE-----NSRFTDC---CLCVAGQEFQAHKAILAARSPVFSA 227
Query: 275 LLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMY 334
+ + ES++ V ++ + P+VF ++ ++Y+ + A D+L+ AD Y
Sbjct: 228 MFEHEMEESKKNR-------VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKY 280
Query: 335 LLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYM 379
L LK +C +L L + + +A L +L+ Q +++
Sbjct: 281 ALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|56117830 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 66.2 bits (160), Expect = 6e-11
Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 16/165 (9%)
Query: 215 DMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRA 274
+M + +C L EL G LWE F C C VAG F HKA RS F A
Sbjct: 177 NMVKVPECRLADEL-GGLWE-----NSRFTDC---CLCVAGQEFQAHKAILAARSPVFSA 227
Query: 275 LLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMY 334
+ + ES++ V ++ + P+VF ++ ++Y+ + A D+L+ AD Y
Sbjct: 228 MFEHEMEESKKNR-------VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKY 280
Query: 335 LLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYM 379
L LK +C +L L + + +A L +L+ Q +++
Sbjct: 281 ALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|56117828 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 66.2 bits (160), Expect = 6e-11
Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 16/165 (9%)
Query: 215 DMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRA 274
+M + +C L EL G LWE F C C VAG F HKA RS F A
Sbjct: 177 NMVKVPECRLADEL-GGLWE-----NSRFTDC---CLCVAGQEFQAHKAILAARSPVFSA 227
Query: 275 LLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMY 334
+ + ES++ V ++ + P+VF ++ ++Y+ + A D+L+ AD Y
Sbjct: 228 MFEHEMEESKKNR-------VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKY 280
Query: 335 LLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYM 379
L LK +C +L L + + +A L +L+ Q +++
Sbjct: 281 ALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|4507183 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 66.2 bits (160), Expect = 6e-11
Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 16/165 (9%)
Query: 215 DMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRA 274
+M + +C L EL G LWE F C C VAG F HKA RS F A
Sbjct: 177 NMVKVPECRLADEL-GGLWE-----NSRFTDC---CLCVAGQEFQAHKAILAARSPVFSA 227
Query: 275 LLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMY 334
+ + ES++ V ++ + P+VF ++ ++Y+ + A D+L+ AD Y
Sbjct: 228 MFEHEMEESKKNR-------VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKY 280
Query: 335 LLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYM 379
L LK +C +L L + + +A L +L+ Q +++
Sbjct: 281 ALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|56117836 speckle-type POZ protein [Homo sapiens]
Length = 374
Score = 66.2 bits (160), Expect = 6e-11
Identities = 46/165 (27%), Positives = 75/165 (45%), Gaps = 16/165 (9%)
Query: 215 DMALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRA 274
+M + +C L EL G LWE F C C VAG F HKA RS F A
Sbjct: 177 NMVKVPECRLADEL-GGLWE-----NSRFTDC---CLCVAGQEFQAHKAILAARSPVFSA 227
Query: 275 LLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMY 334
+ + ES++ V ++ + P+VF ++ ++Y+ + A D+L+ AD Y
Sbjct: 228 MFEHEMEESKKNR-------VEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKY 280
Query: 335 LLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYM 379
L LK +C +L L + + +A L +L+ Q +++
Sbjct: 281 ALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFI 325
>gi|224465242 BTB (POZ) domain containing 8 [Homo sapiens]
Length = 378
Score = 65.5 bits (158), Expect = 1e-10
Identities = 76/271 (28%), Positives = 112/271 (41%), Gaps = 31/271 (11%)
Query: 80 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGAR--SAYFANMLDTKWKGKSVVVLRHPLIN 137
L RLL + H+DV F V F+ H+ VL AR YF + T + + +
Sbjct: 48 LLRLLREEFHTDVTFSVGCTLFKAHKAVLLARVPDFYFHTIGQTSNSLTNQEPIAVENVE 107
Query: 138 PVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLE-AKCEKVSEFVASKPGT 196
+ F LQ +Y+ +I + + + D+ KCE S+ K
Sbjct: 108 ALEFRTFLQIIYSSNRNIKNYEEEILRKKIMEIGISQKQLDISFPKCENSSDCSLQK--- 164
Query: 197 CVKVLTIEPPPADPRLREDMALLAD-CALPP--ELRGDLWELPF-PCPDGFNSCPDICFR 252
P D R+D + D L P EL DL +L PC CPDI
Sbjct: 165 -------HEIPEDISDRDDDFISNDNYDLEPASELGEDLLKLYVKPC------CPDIDIF 211
Query: 253 VAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYM 312
V G F H+A RS YF A+L + ES + VTL GIS +++++
Sbjct: 212 VDGKRFKAHRAILSARSSYFAAMLSGCWAESSQ-------EYVTLQGISHVELNVMMHFI 264
Query: 313 YSDHTELSPEA-AYDVLSVADMYLLPGLKRL 342
Y ++ + +L++ADMY L GLK +
Sbjct: 265 YGGTLDIPDKTNVGQILNMADMYGLEGLKEV 295
>gi|8922528 kelch-like 11 [Homo sapiens]
Length = 708
Score = 65.5 bits (158), Expect = 1e-10
Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 12/150 (8%)
Query: 249 ICFRVAGC-SFLCHKAFFCGRSDYFRALLDDHFRES-----EEPATSGGPPAVTLHGISP 302
+CF AG F H++ ++YF LL F ES E S P G P
Sbjct: 98 LCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEP------GPEP 151
Query: 303 DVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRV 362
D V+ YMY+ +S + ++VL +AD +LL LK CG L + L V + +
Sbjct: 152 DTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSNCVAIHSL 211
Query: 363 AKLFRLARLEDQCTEYMAKVIEKLVEREDF 392
A ++ L++L + + + + K+++ E+F
Sbjct: 212 AHMYTLSQLALKAADMIRRNFHKVIQDEEF 241
Score = 38.5 bits (88), Expect = 0.013
Identities = 27/91 (29%), Positives = 42/91 (46%), Gaps = 9/91 (9%)
Query: 86 QGIHSDVVFV---VHGKPFRVHRCVLGARSAYFANMLDTKW--KGKSVVVLR----HPLI 136
QG+ D+ G+ FR HR VL A + YF +L ++ V +R P
Sbjct: 90 QGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWSSEPGP 149
Query: 137 NPVAFGALLQYLYTGRLDIGVEHVSDCERLA 167
P A+++Y+YTGR+ + V + LA
Sbjct: 150 EPDTVEAVIEYMYTGRIRVSTGSVHEVLELA 180
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 62.4 bits (150), Expect = 8e-10
Identities = 39/162 (24%), Positives = 72/162 (44%), Gaps = 8/162 (4%)
Query: 248 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTH 307
D+ +V G F HK C S YFRAL + +E+ + + GISPD+
Sbjct: 40 DVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYN-------IPGISPDMMKL 92
Query: 308 VLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFR 367
++ Y Y+ ++P+ +L+ AD + + G+ R C L L D +G+ + +
Sbjct: 93 IIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYY 152
Query: 368 LARLEDQCTEYMAKVIEKLVE-REDFVEAVKEEAAAVAARQE 408
L + ++ E++V+ +F+E E + + E
Sbjct: 153 CPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDE 194
Score = 42.7 bits (99), Expect = 7e-04
Identities = 27/107 (25%), Positives = 49/107 (45%), Gaps = 3/107 (2%)
Query: 78 DFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLIN 137
+ L +G DVV V+G F H+ +L + S+YF + + W V P I+
Sbjct: 27 EIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGIS 86
Query: 138 PVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCE 184
P +++Y YT + I ++V E+L ++++ + CE
Sbjct: 87 PDMMKLIIEYAYTRTVPITPDNV---EKLLAAADQFNIMGIVRGCCE 130
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 62.0 bits (149), Expect = 1e-09
Identities = 36/154 (23%), Positives = 71/154 (46%), Gaps = 7/154 (4%)
Query: 254 AGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMY 313
+G F CH+A S+YF+A+ +E + + L GI D+ ++ Y Y
Sbjct: 44 SGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNK-------IKLSGIHHDILEGLVNYAY 96
Query: 314 SDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLED 373
+ E++ +L AD+ +K+ C R L + LD D +G+ A+ LE
Sbjct: 97 TSQIEITKRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEK 156
Query: 374 QCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQ 407
+ + +++ ++E+F+E E+ + +R+
Sbjct: 157 ESRRILCSKFKEVWQQEEFLEISLEKFLFILSRK 190
Score = 34.3 bits (77), Expect = 0.24
Identities = 34/115 (29%), Positives = 48/115 (41%), Gaps = 10/115 (8%)
Query: 74 DYYDDFLQRLLEQGIHSDVVFVV-HGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLR 132
D+ D F L+ G+ +D+ G F HR VL A S YF M K K ++
Sbjct: 21 DFLDAFRTFYLD-GLFTDITLQCPSGIIFHCHRAVLAACSNYFKAMFTADMKEKFKNKIK 79
Query: 133 HPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAK--CEK 185
I+ L+ Y YT +++I +V A DLL L K CE+
Sbjct: 80 LSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAA------DLLQFLSVKKACER 128
>gi|151108413 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
Length = 612
Score = 61.6 bits (148), Expect = 1e-09
Identities = 45/162 (27%), Positives = 70/162 (43%), Gaps = 9/162 (5%)
Query: 248 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTH 307
D+ F V F H+ R YFRALL RES+ A + L + + FT
Sbjct: 37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEA------EIPLQDTTAEAFTM 90
Query: 308 VLYYMYSDH---TELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAK 364
+L Y+Y+ T+ E D LS+A Y P L+ L +L+ V + VA
Sbjct: 91 LLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTFDVAS 150
Query: 365 LFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAAR 406
L+ L +L C +M + ++++ E F+ K + R
Sbjct: 151 LYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLR 192
Score = 40.4 bits (93), Expect = 0.003
Identities = 27/66 (40%), Positives = 35/66 (53%), Gaps = 3/66 (4%)
Query: 89 HSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPV--AFGALLQ 146
+ DV FVV K F HR +L AR YF +L + +S PL + AF LL+
Sbjct: 35 YGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMR-ESQPEAEIPLQDTTAEAFTMLLK 93
Query: 147 YLYTGR 152
Y+YTGR
Sbjct: 94 YIYTGR 99
>gi|151108411 BTB (POZ) domain containing 9 isoform a [Homo sapiens]
Length = 612
Score = 61.6 bits (148), Expect = 1e-09
Identities = 45/162 (27%), Positives = 70/162 (43%), Gaps = 9/162 (5%)
Query: 248 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTH 307
D+ F V F H+ R YFRALL RES+ A + L + + FT
Sbjct: 37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEA------EIPLQDTTAEAFTM 90
Query: 308 VLYYMYSDH---TELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAK 364
+L Y+Y+ T+ E D LS+A Y P L+ L +L+ V + VA
Sbjct: 91 LLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTFDVAS 150
Query: 365 LFRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAAR 406
L+ L +L C +M + ++++ E F+ K + R
Sbjct: 151 LYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLR 192
Score = 40.4 bits (93), Expect = 0.003
Identities = 27/66 (40%), Positives = 35/66 (53%), Gaps = 3/66 (4%)
Query: 89 HSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPV--AFGALLQ 146
+ DV FVV K F HR +L AR YF +L + +S PL + AF LL+
Sbjct: 35 YGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMR-ESQPEAEIPLQDTTAEAFTMLLK 93
Query: 147 YLYTGR 152
Y+YTGR
Sbjct: 94 YIYTGR 99
>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
Length = 1353
Score = 61.2 bits (147), Expect = 2e-09
Identities = 97/427 (22%), Positives = 160/427 (37%), Gaps = 77/427 (18%)
Query: 23 HEELVLYLLANGARCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQR 82
+E + L L R + + D C + L + +L + V++S ++++F +
Sbjct: 498 YERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSS----SFFEEFGKL 553
Query: 83 LLE----QGIHSDVVFVVHGKPFRVHRCVLGARSAYFANML---------------DTKW 123
L E IH DV F V + F H+ +L S +F + D
Sbjct: 554 LREADEMDSIH-DVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDS 612
Query: 124 KGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWD--LLSDLEA 181
G + V+ ++P F LLQ++YT D L K + + L S L
Sbjct: 613 AGCHLFVVEK--VHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNK 670
Query: 182 -------------------KCEKVSEFVASKPGTCVKVLTIEPPPADP-RLREDMALLAD 221
+ + VSE SKP +C K I DP R+ + +A D
Sbjct: 671 VNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIRED--DPVRMLQTVAKKFD 728
Query: 222 CA-LPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLC--------------HKAFFC 266
+ L L G +E N+ + CSFLC HK C
Sbjct: 729 FSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLC 788
Query: 267 GRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEA--- 323
R +YF ++L + E+ A P I D+ +L Y+Y+D + E+
Sbjct: 789 ARLEYFHSMLSSSWIEASSCAALEMP-------IHSDILKVILDYLYTDEAVVIKESQNV 841
Query: 324 --AYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAK 381
VL VAD L+ LK +C +L + L + A ++ +L+ C +++
Sbjct: 842 DFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGL 901
Query: 382 VIEKLVE 388
+ L+E
Sbjct: 902 NMAALLE 908
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 59.7 bits (143), Expect = 5e-09
Identities = 37/132 (28%), Positives = 58/132 (43%), Gaps = 7/132 (5%)
Query: 255 GCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYS 314
G F H+A S YFRA+ RES V LHG+ PD+ +L + Y+
Sbjct: 44 GRDFPAHRAVLAAASPYFRAMFAGQLRESRAER-------VRLHGVPPDMLQLLLDFSYT 96
Query: 315 DHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQ 374
+S + A +L AD+ P +K CG L Q LD + + A+ F + L
Sbjct: 97 GRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASA 156
Query: 375 CTEYMAKVIEKL 386
++ + + +L
Sbjct: 157 AQRFILRHVGEL 168
Score = 34.7 bits (78), Expect = 0.18
Identities = 22/74 (29%), Positives = 32/74 (43%)
Query: 98 GKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDIGV 157
G+ F HR VL A S YF M + + +R + P LL + YTGR+ +
Sbjct: 44 GRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSG 103
Query: 158 EHVSDCERLAKQCQ 171
++ R A Q
Sbjct: 104 DNAEPLLRAADLLQ 117
>gi|211904190 hypothetical protein LOC149478 [Homo sapiens]
Length = 291
Score = 58.9 bits (141), Expect = 9e-09
Identities = 44/167 (26%), Positives = 78/167 (46%), Gaps = 12/167 (7%)
Query: 248 DICFRVAG--CSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVF 305
D+CF V H+ R ++F+ LL EP G P V L + + F
Sbjct: 30 DVCFVVGQERQEVFAHRCLLACRCNFFQRLL------GTEPGP-GVPSPVVLSTVPTEAF 82
Query: 306 THVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKL 365
VL ++Y++ +L + +VL+ A Y L L+ LC + + ++LD D V +VA
Sbjct: 83 LAVLEFLYTNSVKLYRHSVLEVLTAAVEYGLEELRELCLQFVVKVLDVDLVCEALQVAVT 142
Query: 366 FRLARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSI 412
F L +L+++C ++ ++ + F+E AAA+ +D +
Sbjct: 143 FGLGQLQERCVAFIEAHSQEALRTRGFLEL---SAAALLPLLRSDKL 186
Score = 35.4 bits (80), Expect = 0.11
Identities = 49/169 (28%), Positives = 72/169 (42%), Gaps = 20/169 (11%)
Query: 80 LQRLLEQGIHSDVVFVVHGKPFRV--HRCVLGARSAYFANMLDTKWKGKSV---VVLRHP 134
L+ L+ +SDV FVV + V HRC+L R +F +L T+ G V VVL
Sbjct: 19 LRSLVNNPRYSDVCFVVGQERQEVFAHRCLLACRCNFFQRLLGTE-PGPGVPSPVVL--S 75
Query: 135 LINPVAFGALLQYLYTGRLDIGVEHVSD---------CERLAKQC-QLWDLLSDLEAKCE 184
+ AF A+L++LYT + + V + E L + C Q + D++ CE
Sbjct: 76 TVPTEAFLAVLEFLYTNSVKLYRHSVLEVLTAAVEYGLEELRELCLQFVVKVLDVDLVCE 135
Query: 185 KVSEFVASKPGTCVK--VLTIEPPPADPRLREDMALLADCALPPELRGD 231
+ V G + V IE + L+ AL P LR D
Sbjct: 136 ALQVAVTFGLGQLQERCVAFIEAHSQEALRTRGFLELSAAALLPLLRSD 184
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 58.9 bits (141), Expect = 9e-09
Identities = 40/131 (30%), Positives = 58/131 (44%), Gaps = 7/131 (5%)
Query: 258 FLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHT 317
F HKA SDYFRA+ ES G V LHG++ L + Y+
Sbjct: 53 FHAHKAVLAACSDYFRAMFSLCMVES-------GADEVNLHGVTSLGLKQALEFAYTGQI 105
Query: 318 ELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTE 377
L P DVL+ L L LC L Q L+ + ++R+A LF L LE +
Sbjct: 106 LLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELNSFNYLDLYRLADLFNLTLLEKAVID 165
Query: 378 YMAKVIEKLVE 388
++ K + +L++
Sbjct: 166 FLVKHLSELLK 176
>gi|48717263 speckle-type POZ protein-like [Homo sapiens]
Length = 392
Score = 58.5 bits (140), Expect = 1e-08
Identities = 42/159 (26%), Positives = 72/159 (45%), Gaps = 16/159 (10%)
Query: 221 DCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHF 280
+C L +L G+LWE F C F V G F HK+ RS F A+ +
Sbjct: 183 ECRLAEDL-GNLWE-----NTRFTDCS---FFVRGQEFKAHKSVLAARSPVFNAMFEHEM 233
Query: 281 RESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLK 340
ES++ V ++ + P+VF ++ ++Y+ + A ++L+ AD Y L LK
Sbjct: 234 EESKKNR-------VEINDLDPEVFKEMMRFIYTGRAPNLDKMADNLLAAADKYALERLK 286
Query: 341 RLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYM 379
+C +L L + V +A L +L+ Q +++
Sbjct: 287 VMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFI 325
Score = 40.0 bits (92), Expect = 0.004
Identities = 22/73 (30%), Positives = 37/73 (50%)
Query: 80 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPV 139
L L E +D F V G+ F+ H+ VL ARS F M + + + + ++P
Sbjct: 190 LGNLWENTRFTDCSFFVRGQEFKAHKSVLAARSPVFNAMFEHEMEESKKNRVEINDLDPE 249
Query: 140 AFGALLQYLYTGR 152
F +++++YTGR
Sbjct: 250 VFKEMMRFIYTGR 262
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 58.5 bits (140), Expect = 1e-08
Identities = 40/172 (23%), Positives = 67/172 (38%), Gaps = 7/172 (4%)
Query: 248 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTH 307
D+ + +F HK SDYFRA+ RE+ + + L G+S H
Sbjct: 64 DVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDV-------IELKGVSARGLRH 116
Query: 308 VLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFR 367
++ + YS L + DVL A + + LC L + +T + + ++A F
Sbjct: 117 IIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTFS 176
Query: 368 LARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIR 419
LA L + + + ++ E EDF+ E S +D R
Sbjct: 177 LASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFR 228
Score = 32.3 bits (72), Expect = 0.91
Identities = 21/83 (25%), Positives = 37/83 (44%)
Query: 80 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPV 139
L L QG DVV ++ + F H+ VL A S YF M + S V+ ++
Sbjct: 53 LATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSAR 112
Query: 140 AFGALLQYLYTGRLDIGVEHVSD 162
++ + Y+ + + ++ V D
Sbjct: 113 GLRHIIDFAYSAEVTLDLDCVQD 135
>gi|45593142 kelch repeat and BTB (POZ) domain containing 5 [Homo
sapiens]
Length = 621
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/203 (25%), Positives = 84/203 (41%), Gaps = 13/203 (6%)
Query: 248 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTH 307
D R F CH+ S YFRA R EP +G + L +SPDV
Sbjct: 34 DCVVRAGEREFPCHRLVLAACSPYFRA------RFLAEPERAG---ELHLEEVSPDVVAQ 84
Query: 308 VLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFR 367
VL+Y+Y+ L + D+ + A + +P + +C L + L + V+R+ L
Sbjct: 85 VLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFRLGLLLD 144
Query: 368 LARLEDQCTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQ 427
ARL +++ + DF+ +E A+ + +D + + + A
Sbjct: 145 CARLAVAARDFICAHFTLVARDADFLGLSADELIAIIS---SDGLNVEKEEAVFEAVMRW 201
Query: 428 TYSAIEEAQ-QRLRALEDLLVSI 449
S EAQ +R RAL + S+
Sbjct: 202 AGSGDAEAQAERQRALPTVFESV 224
Score = 33.1 bits (74), Expect = 0.53
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 2/95 (2%)
Query: 78 DFLQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLIN 137
D L+ +L+ G D V + F HR VL A S YF + + + L ++
Sbjct: 21 DGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEE--VS 78
Query: 138 PVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQL 172
P +L YLYT + + V D A + Q+
Sbjct: 79 PDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQI 113
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 57.0 bits (136), Expect = 3e-08
Identities = 32/135 (23%), Positives = 58/135 (42%), Gaps = 7/135 (5%)
Query: 258 FLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHT 317
F+ HK S F+A+ + RE G V++ GI P V ++ + Y+
Sbjct: 93 FMAHKVVLASSSPVFKAMFTNGLREQ-------GMEVVSIEGIHPKVMERLIEFAYTASI 145
Query: 318 ELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTE 377
+ + V++ A MY + + R C L Q LD +G+ A+ L + E
Sbjct: 146 SMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRARE 205
Query: 378 YMAKVIEKLVEREDF 392
Y+ ++ ++E+F
Sbjct: 206 YIYMHFGEVAKQEEF 220
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 57.0 bits (136), Expect = 3e-08
Identities = 32/135 (23%), Positives = 58/135 (42%), Gaps = 7/135 (5%)
Query: 258 FLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHT 317
F+ HK S F+A+ + RE G V++ GI P V ++ + Y+
Sbjct: 93 FMAHKVVLASSSPVFKAMFTNGLREQ-------GMEVVSIEGIHPKVMERLIEFAYTASI 145
Query: 318 ELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTE 377
+ + V++ A MY + + R C L Q LD +G+ A+ L + E
Sbjct: 146 SMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRARE 205
Query: 378 YMAKVIEKLVEREDF 392
Y+ ++ ++E+F
Sbjct: 206 YIYMHFGEVAKQEEF 220
>gi|209571547 kelch repeat and BTB (POZ) domain containing 4 isoform
a [Homo sapiens]
Length = 534
Score = 56.6 bits (135), Expect = 4e-08
Identities = 38/133 (28%), Positives = 68/133 (51%), Gaps = 13/133 (9%)
Query: 84 LEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWK--GKSVVVLRHPLINPVAF 141
LE+ + +DV V G+ F++HR VL A+S +F +M + K V+VL+ ++ F
Sbjct: 55 LEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQD--VSESVF 112
Query: 142 GALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVAS--KPGTCVK 199
L+ Y+Y G + + E + + ++ QL L E+ S F+A + G C++
Sbjct: 113 QLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLF-------EECSRFLARTVQVGNCLQ 165
Query: 200 VLTIEPPPADPRL 212
V+ + +DP L
Sbjct: 166 VMWLADRHSDPEL 178
Score = 47.0 bits (110), Expect = 4e-05
Identities = 27/102 (26%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 248 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTH 307
D+ V G F H+ +S +FR++ + +E+ + L +S VF
Sbjct: 62 DVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRV-------IVLQDVSESVFQL 114
Query: 308 VLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQ 349
++ Y+Y +L E ++ V+DMY L L C R LA+
Sbjct: 115 LVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLAR 156
>gi|209693446 kelch repeat and BTB (POZ) domain containing 4 isoform
b [Homo sapiens]
Length = 518
Score = 56.6 bits (135), Expect = 4e-08
Identities = 38/133 (28%), Positives = 68/133 (51%), Gaps = 13/133 (9%)
Query: 84 LEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANMLDTKWK--GKSVVVLRHPLINPVAF 141
LE+ + +DV V G+ F++HR VL A+S +F +M + K V+VL+ ++ F
Sbjct: 39 LEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQD--VSESVF 96
Query: 142 GALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVAS--KPGTCVK 199
L+ Y+Y G + + E + + ++ QL L E+ S F+A + G C++
Sbjct: 97 QLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLF-------EECSRFLARTVQVGNCLQ 149
Query: 200 VLTIEPPPADPRL 212
V+ + +DP L
Sbjct: 150 VMWLADRHSDPEL 162
Score = 47.0 bits (110), Expect = 4e-05
Identities = 27/102 (26%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 248 DICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTH 307
D+ V G F H+ +S +FR++ + +E+ + L +S VF
Sbjct: 46 DVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRV-------IVLQDVSESVFQL 98
Query: 308 VLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQ 349
++ Y+Y +L E ++ V+DMY L L C R LA+
Sbjct: 99 LVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLAR 140
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 56.2 bits (134), Expect = 6e-08
Identities = 40/189 (21%), Positives = 81/189 (42%), Gaps = 12/189 (6%)
Query: 255 GCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYS 314
G +F CH+ S YFR++ ES + V + G+ + VL Y Y+
Sbjct: 58 GKTFSCHRNVLAAISPYFRSMFTSGLTESTQKE-------VRIVGVEAESMDLVLNYAYT 110
Query: 315 DHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQ 374
L+ + + A ++ +P ++ C + + LD +GV+ A + L D+
Sbjct: 111 SRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDR 170
Query: 375 CTEYMAKVIEKLVEREDFVEAVKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEE 434
EY+ K + + ++F++ K++ ++ DS L D HV ++ + E+
Sbjct: 171 SKEYIRKKFLCVTKEQEFLQLTKDQLISI-----LDSDDLNVDREEHVYESIIRWFEHEQ 225
Query: 435 AQQRLRALE 443
++ + E
Sbjct: 226 NEREVHLPE 234
Score = 38.1 bits (87), Expect = 0.017
Identities = 24/75 (32%), Positives = 38/75 (50%), Gaps = 1/75 (1%)
Query: 80 LQRLLEQGIHSDVVFVV-HGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINP 138
L+ + ++G +D+V V HGK F HR VL A S YF +M + + +R +
Sbjct: 39 LKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEA 98
Query: 139 VAFGALLQYLYTGRL 153
+ +L Y YT R+
Sbjct: 99 ESMDLVLNYAYTSRV 113
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 55.8 bits (133), Expect = 8e-08
Identities = 33/151 (21%), Positives = 67/151 (44%), Gaps = 7/151 (4%)
Query: 244 NSCPDICFRVAGCSFLCHKAFFCGRSDYFRALLDDHFRESEEPATSGGPPAVTLHGISPD 303
N+ D+ V F CH+ S+YFRA+ + +E E + + G+ +
Sbjct: 69 NALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKR-------IIIKGVDAE 121
Query: 304 VFTHVLYYMYSDHTELSPEAAYDVLSVADMYLLPGLKRLCGRSLAQMLDEDTVVGVWRVA 363
+L Y Y+ ++ + VL A+++ + C L + L+ + VG+ R+A
Sbjct: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
Query: 364 KLFRLARLEDQCTEYMAKVIEKLVEREDFVE 394
L L+ Q Y+ + +++ E+F++
Sbjct: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLD 212
Score = 41.6 bits (96), Expect = 0.001
Identities = 35/126 (27%), Positives = 60/126 (47%), Gaps = 9/126 (7%)
Query: 80 LQRLLEQGIHSDVVFVVHGKPFRVHRCVLGARSAYFANML--DTKWKGKSVVVLRHPLIN 137
L+ L + +DV+ V + F HR VL A S YF M D K K + ++++ ++
Sbjct: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKG--VD 119
Query: 138 PVAFGALLQYLYTGRLDIGVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTC 197
LL Y YT + I ++V +R+ + L+ L ++A ++E A P C
Sbjct: 120 AETMHTLLDYTYTSKALITKQNV---QRVLEAANLFQFLRMVDACASFLTE--ALNPENC 174
Query: 198 VKVLTI 203
V +L +
Sbjct: 175 VGILRL 180
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,866,528
Number of Sequences: 37866
Number of extensions: 887805
Number of successful extensions: 3534
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 127
Number of HSP's successfully gapped in prelim test: 67
Number of HSP's that attempted gapping in prelim test: 3088
Number of HSP's gapped (non-prelim): 398
length of query: 453
length of database: 18,247,518
effective HSP length: 106
effective length of query: 347
effective length of database: 14,233,722
effective search space: 4939101534
effective search space used: 4939101534
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.