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Search of human proteins with 24850117
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo
sapiens]
(1303 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 2649 0.0
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 2626 0.0
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 2608 0.0
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 2556 0.0
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 1682 0.0
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 1668 0.0
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 1667 0.0
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 1653 0.0
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 1598 0.0
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 1592 0.0
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 1584 0.0
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 1578 0.0
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 1547 0.0
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 1467 0.0
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 791 0.0
gi|118600963 Nik related kinase [Homo sapiens] 405 e-112
gi|145275208 myosin IIIA [Homo sapiens] 310 8e-84
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 292 2e-78
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 292 2e-78
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 264 4e-70
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 262 2e-69
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 257 4e-68
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 257 4e-68
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 256 8e-68
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 256 1e-67
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 253 8e-67
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 249 9e-66
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 249 9e-66
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 243 7e-64
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 242 1e-63
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 2649 bits (6866), Expect = 0.0
Identities = 1303/1303 (100%), Positives = 1303/1303 (100%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
Query: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH 720
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH
Sbjct: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH 720
Query: 721 LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERT 780
LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERT
Sbjct: 721 LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERT 780
Query: 781 LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVH 840
LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVH
Sbjct: 781 LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVH 840
Query: 841 DVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPP 900
DVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPP
Sbjct: 841 DVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPP 900
Query: 901 SKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV 960
SKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV
Sbjct: 901 SKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV 960
Query: 961 RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1020
RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG
Sbjct: 961 RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1020
Query: 1021 KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT 1080
KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT
Sbjct: 1021 KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT 1080
Query: 1081 VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL 1140
VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL
Sbjct: 1081 VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL 1140
Query: 1141 TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC 1200
TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC
Sbjct: 1141 TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC 1200
Query: 1201 YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM 1260
YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM
Sbjct: 1201 YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM 1260
Query: 1261 HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
Sbjct: 1261 HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 2626 bits (6807), Expect = 0.0
Identities = 1295/1303 (99%), Positives = 1295/1303 (99%), Gaps = 8/1303 (0%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
Query: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH 720
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH
Sbjct: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRASNPDLRRSDPGWERSDSVLPASHGH 720
Query: 721 LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERT 780
LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPA DFVLLKERT
Sbjct: 721 LPQAGSLERNRVGVSSKPDSSPVLSPGNKAKPDDHRSRPGRPA--------DFVLLKERT 772
Query: 781 LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVH 840
LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVH
Sbjct: 773 LDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVH 832
Query: 841 DVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPP 900
DVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPP
Sbjct: 833 DVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPP 892
Query: 901 SKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV 960
SKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV
Sbjct: 893 SKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDV 952
Query: 961 RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1020
RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG
Sbjct: 953 RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1012
Query: 1021 KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT 1080
KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT
Sbjct: 1013 KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT 1072
Query: 1081 VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL 1140
VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL
Sbjct: 1073 VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL 1132
Query: 1141 TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC 1200
TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC
Sbjct: 1133 TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC 1192
Query: 1201 YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM 1260
YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM
Sbjct: 1193 YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM 1252
Query: 1261 HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW
Sbjct: 1253 HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 2608 bits (6759), Expect = 0.0
Identities = 1295/1340 (96%), Positives = 1295/1340 (96%), Gaps = 45/1340 (3%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
Query: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA------------------------- 695
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA
Sbjct: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 720
Query: 696 ------------SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 743
SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 721 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 780
Query: 744 LSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVES 803
LSPGNKAKPDDHRSRPGRPA DFVLLKERTLDEAPRPPKKAMDYSSSSEEVES
Sbjct: 781 LSPGNKAKPDDHRSRPGRPA--------DFVLLKERTLDEAPRPPKKAMDYSSSSEEVES 832
Query: 804 SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP 863
SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP
Sbjct: 833 SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP 892
Query: 864 EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT 923
EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT
Sbjct: 893 EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT 952
Query: 924 MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR 983
MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR
Sbjct: 953 MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR 1012
Query: 984 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1043
KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL
Sbjct: 1013 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1072
Query: 1044 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1103
ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI
Sbjct: 1073 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1132
Query: 1104 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1163
ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV
Sbjct: 1133 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1192
Query: 1164 DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG 1223
DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG
Sbjct: 1193 DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG 1252
Query: 1224 EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1283
EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
Sbjct: 1253 EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1312
Query: 1284 SGGSSQVYFMTLNRNCIMNW 1303
SGGSSQVYFMTLNRNCIMNW
Sbjct: 1313 SGGSSQVYFMTLNRNCIMNW 1332
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 2556 bits (6625), Expect = 0.0
Identities = 1275/1340 (95%), Positives = 1275/1340 (95%), Gaps = 65/1340 (4%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL
Sbjct: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSL------------------ 582
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 660
QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP
Sbjct: 583 --QDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRP 640
Query: 661 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA------------------------- 695
DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRA
Sbjct: 641 DNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPG 700
Query: 696 ------------SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 743
SNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV
Sbjct: 701 PPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPV 760
Query: 744 LSPGNKAKPDDHRSRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVES 803
LSPGNKAKPDDHRSRPGRPA DFVLLKERTLDEAPRPPKKAMDYSSSSEEVES
Sbjct: 761 LSPGNKAKPDDHRSRPGRPA--------DFVLLKERTLDEAPRPPKKAMDYSSSSEEVES 812
Query: 804 SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP 863
SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP
Sbjct: 813 SEDDEEEGEGGPAEGSRDTPGGRSDGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTP 872
Query: 864 EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT 923
EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT
Sbjct: 873 EEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFT 932
Query: 924 MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR 983
MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR
Sbjct: 933 MFVDLGIYQPGGSGDSIPITALVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIR 992
Query: 984 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1043
KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL
Sbjct: 993 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1052
Query: 1044 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1103
ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI
Sbjct: 1053 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1112
Query: 1104 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1163
ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV
Sbjct: 1113 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1172
Query: 1164 DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG 1223
DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG
Sbjct: 1173 DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG 1232
Query: 1224 EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1283
EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
Sbjct: 1233 EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1292
Query: 1284 SGGSSQVYFMTLNRNCIMNW 1303
SGGSSQVYFMTLNRNCIMNW
Sbjct: 1293 SGGSSQVYFMTLNRNCIMNW 1312
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 1682 bits (4357), Expect = 0.0
Identities = 905/1370 (66%), Positives = 1043/1370 (76%), Gaps = 106/1370 (7%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+EVEER+R+N+Q +SP
Sbjct: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
Query: 541 KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597
K + +P +P S ++TPPM RPV+PQ + H V +K +
Sbjct: 525 KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577
Query: 598 RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 578 ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626
Query: 653 -NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSD 704
+ +W+R + + PPKVPQRT+SI+ AL N S G +Q +RASNPDLRR++
Sbjct: 627 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 686
Query: 705 PGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-P 746
P E S S P+S G P QAGS ER RV +SK + SPVL
Sbjct: 687 PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 746
Query: 747 GNKAKPDDHR--SRPGRPASYKRAIGEDFVLL----KERTLDEAPRPPKKAMDYSSSSEE 800
K KP++ R +RP RPASYK+AI ED L +E ++E RP KK DYSSSSEE
Sbjct: 747 PAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEE 806
Query: 801 VESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPY 852
ESSE++EE+GE +G+ D P G + +V + H +E T +
Sbjct: 807 SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSF 864
Query: 853 GG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPP 900
G GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S
Sbjct: 865 SGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTH 924
Query: 901 SKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLD 954
S++ SG G + K+SFT FVD +YQ + + AL E R +
Sbjct: 925 SQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQE 981
Query: 955 QLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML 1013
Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML
Sbjct: 982 QAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML 1041
Query: 1014 LDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVE 1073
LDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVE
Sbjct: 1042 LDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVE 1101
Query: 1074 KKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPH 1133
KKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H
Sbjct: 1102 KKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQH 1161
Query: 1134 RPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTD 1193
+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TD
Sbjct: 1162 KPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTD 1221
Query: 1194 GMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETG 1253
GMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETG
Sbjct: 1222 GMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETG 1281
Query: 1254 HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1282 HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1331
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 1668 bits (4320), Expect = 0.0
Identities = 899/1366 (65%), Positives = 1036/1366 (75%), Gaps = 106/1366 (7%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+EVEER+R+N+Q +SP
Sbjct: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
Query: 541 KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597
K + +P +P S ++TPPM RPV+PQ + H V +K +
Sbjct: 525 KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577
Query: 598 RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 578 ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626
Query: 653 -NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSD 704
+ +W+R + + PPKVPQRT+SI+ AL N S G +Q +RASNPDLRR++
Sbjct: 627 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 686
Query: 705 PGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-P 746
P E S S P+S G P QAGS ER RV +SK + SPVL
Sbjct: 687 PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 746
Query: 747 GNKAKPDDHR--SRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVESS 804
K KP++ R +RP RPA E L+E ++E RP KK DYSSSSEE ESS
Sbjct: 747 PAKVKPEESRDITRPSRPADLTALAKE----LRELRIEETNRPMKKVTDYSSSSEESESS 802
Query: 805 EDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-- 854
E++EE+GE +G+ D P G + +V + H +E T + G
Sbjct: 803 EEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSI 860
Query: 855 ---GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD- 903
GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S++
Sbjct: 861 SREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEM 920
Query: 904 GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY 958
SG G + K+SFT FVD +YQ + + AL E R +Q +
Sbjct: 921 DSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKL 977
Query: 959 -DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRS 1017
+ RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRS
Sbjct: 978 NEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRS 1037
Query: 1018 GQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQG 1077
GQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQG
Sbjct: 1038 GQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQG 1097
Query: 1078 WTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLL 1137
W TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLL
Sbjct: 1098 WITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLL 1157
Query: 1138 VDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEM 1197
VDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEM
Sbjct: 1158 VDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEM 1217
Query: 1198 LLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDG 1257
L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDG
Sbjct: 1218 LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDG 1277
Query: 1258 VFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
VFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1278 VFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1323
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 1667 bits (4317), Expect = 0.0
Identities = 905/1399 (64%), Positives = 1043/1399 (74%), Gaps = 135/1399 (9%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- 451
QE+EQ+R E+ +RREEERR+AE EQEY
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
Query: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
+P++KPAWA+EVEER+R+N+Q +SP K + +P +P S ++TPPM
Sbjct: 526 SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584
Query: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTA 628
RPV+PQ + H V +K + SQS+ +QPT+ L+ F + +
Sbjct: 585 LRPVDPQ-------IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN---------- 627
Query: 629 TPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATAL--- 679
S R + RQNSDPTSE P P P + +W+R + + PPKVPQRT+SI+ AL
Sbjct: 628 VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARK 686
Query: 680 ----NTSGAGGSRPAQAVRASNPDLRRSDPGWER----------SDSVLPASH-----GH 720
N S G +Q +RASNPDLRR++P E S S P+S G
Sbjct: 687 NSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGS 746
Query: 721 LP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPASYKRAIGEDFVL 775
P QAGS ER RV +SK + SPVL K KP++ R +RP RPASYK+AI ED
Sbjct: 747 QPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTA 806
Query: 776 L----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP----- 823
L +E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P
Sbjct: 807 LAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPT 866
Query: 824 GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT 878
G + +V + H +E T + G GT++++ T E++ H+DSNG+
Sbjct: 867 GAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFA 924
Query: 879 ---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGI 930
NLPD+VQ SHSP TE S S++ SG G + K+SFT FVD +
Sbjct: 925 GHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRV 981
Query: 931 YQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRK 984
YQ + + AL E R +Q + + RK SVVNVNPTN R HS+TPEIRK
Sbjct: 982 YQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRK 1041
Query: 985 YKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLI 1044
YKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+
Sbjct: 1042 YKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLV 1101
Query: 1045 TISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIA 1104
TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIA
Sbjct: 1102 TISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIA 1161
Query: 1105 LKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVD 1164
LK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVD
Sbjct: 1162 LKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVD 1221
Query: 1165 SGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGE 1224
SGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGE
Sbjct: 1222 SGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGE 1281
Query: 1225 MPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRS 1284
MPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRS
Sbjct: 1282 MPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRS 1341
Query: 1285 GGSSQVYFMTLNRNCIMNW 1303
GGSSQV+FMTLNRN +MNW
Sbjct: 1342 GGSSQVFFMTLNRNSMMNW 1360
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 1653 bits (4280), Expect = 0.0
Identities = 899/1395 (64%), Positives = 1036/1395 (74%), Gaps = 135/1395 (9%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEY----------------------------- 451
QE+EQ+R E+ +RREEERR+AE EQEY
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 452 KRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGM 511
KRKQLEEQRQ+ERLQRQL+QE YL SLQ Q+Q+Q+ P ++KPLYHY GM
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR----------PVEKKPLYHYKEGM 525
Query: 512 NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPG---PPGPLSQTPPM 568
+P++KPAWA+EVEER+R+N+Q +SP K + +P +P S ++TPPM
Sbjct: 526 SPSEKPAWAKEVEERSRLNRQ-SSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPM 584
Query: 569 QRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAIPAPTA 628
RPV+PQ + H V +K + SQS+ +QPT+ L+ F + +
Sbjct: 585 LRPVDPQ-------IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALN---------- 627
Query: 629 TPSARGAVIRQNSDPTSEGPGPSP------NPPAWVRPDNEAPPKVPQRTSSIATAL--- 679
S R + RQNSDPTSE P P P + +W+R + + PPKVPQRT+SI+ AL
Sbjct: 628 VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARK 686
Query: 680 ----NTSGAGGSRPAQAVRASNPDLRRSDPGWER----------SDSVLPASH-----GH 720
N S G +Q +RASNPDLRR++P E S S P+S G
Sbjct: 687 NSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGS 746
Query: 721 LP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPASYKRAIGEDFVL 775
P QAGS ER RV +SK + SPVL K KP++ R +RP RPA E
Sbjct: 747 QPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKE---- 802
Query: 776 LKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRS 827
L+E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G
Sbjct: 803 LRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPG 862
Query: 828 DGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---N 879
+ +V + H +E T + G GT++++ T E++ H+DSNG+ N
Sbjct: 863 SNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHIN 920
Query: 880 LPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPG 934
LPD+VQ SHSP TE S S++ SG G + K+SFT FVD +YQ
Sbjct: 921 LPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTS 977
Query: 935 GSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKR 988
+ + AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKR
Sbjct: 978 PTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKR 1037
Query: 989 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISG 1048
FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISG
Sbjct: 1038 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISG 1097
Query: 1049 KRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSS 1108
K+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++
Sbjct: 1098 KKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNA 1157
Query: 1109 VEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNS 1168
VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNS
Sbjct: 1158 VEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNS 1217
Query: 1169 YDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTS 1228
YDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTS
Sbjct: 1218 YDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTS 1277
Query: 1229 VAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSS 1288
VAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSS
Sbjct: 1278 VAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSS 1337
Query: 1289 QVYFMTLNRNCIMNW 1303
QV+FMTLNRN +MNW
Sbjct: 1338 QVFFMTLNRNSMMNW 1352
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 1598 bits (4138), Expect = 0.0
Identities = 878/1367 (64%), Positives = 1004/1367 (73%), Gaps = 155/1367 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q +Q+Q R VE++ PL
Sbjct: 476 HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
K G + P ++P +E PH V +K + SQ
Sbjct: 493 KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654
S+ +QPT+ L+ F + + S R + RQNSDPTSE P P P +
Sbjct: 526 SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574
Query: 655 PAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSDPGW 707
+W+R + + PPKVPQRT+SI+ AL N S G +Q +RASNPDLRR++P
Sbjct: 575 SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL 634
Query: 708 ER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNK 749
E S S P+S G P QAGS ER RV +SK + SPVL K
Sbjct: 635 ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK 694
Query: 750 AKPDDHR--SRPGRPASYKRAIGEDFVLL----KERTLDEAPRPPKKAMDYSSSSEEVES 803
KP++ R +RP RPASYK+AI ED L +E ++E RP KK DYSSSSEE ES
Sbjct: 695 VKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESES 754
Query: 804 SEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG- 854
SE++EE+GE +G+ D P G + +V + H +E T + G
Sbjct: 755 SEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGS 812
Query: 855 ----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD 903
GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S++
Sbjct: 813 ISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQE 872
Query: 904 -GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQ 957
SG G + K+SFT FVD +YQ + + AL E R +Q +
Sbjct: 873 MDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 929
Query: 958 Y-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 1016
+ RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR
Sbjct: 930 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 989
Query: 1017 SGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQ 1076
SGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQ
Sbjct: 990 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1049
Query: 1077 GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPL 1136
GW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PL
Sbjct: 1050 GWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPL 1109
Query: 1137 LVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGME 1196
LVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGME
Sbjct: 1110 LVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGME 1169
Query: 1197 MLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLD 1256
ML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLD
Sbjct: 1170 MLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLD 1229
Query: 1257 GVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
GVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1230 GVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1276
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 1592 bits (4123), Expect = 0.0
Identities = 874/1371 (63%), Positives = 1007/1371 (73%), Gaps = 134/1371 (9%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEE-QRQSERLQRQLQQEHAYLKSL 479
QE+EQ+R E+ +RREEERR+AE EQEY R+QLEE QRQ E LQ+QL E A L
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 480 QQQQQQQQLQKQQQQQLLPGDRK---PLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
+++Q ++Q Q ++ Q+ L +R L H + P +K P
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK------------------KP 517
Query: 537 LAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV 596
L K G + P ++P +E PH V +K +
Sbjct: 518 LYHYKEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPAL 550
Query: 597 PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP---- 652
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 551 TASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIE 599
Query: 653 --NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRS 703
+ +W+R + + PPKVPQRT+SI+ AL N S G +Q +RASNPDLRR+
Sbjct: 600 KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRT 659
Query: 704 DPGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS- 745
+P E S S P+S G P QAGS ER RV +SK + SPVL
Sbjct: 660 EPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPH 719
Query: 746 PGNKAKPDDHR--SRPGRPASYKRAIGEDFVLL----KERTLDEAPRPPKKAMDYSSSSE 799
K KP++ R +RP RPASYK+AI ED L +E ++E RP KK DYSSSSE
Sbjct: 720 EPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSE 779
Query: 800 EVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPP 851
E ESSE++EE+GE +G+ D P G + +V + H +E T
Sbjct: 780 ESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADS 837
Query: 852 YGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSP 899
+ G GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S
Sbjct: 838 FSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVST 897
Query: 900 PSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRL 953
S++ SG G + K+SFT FVD +YQ + + AL E R
Sbjct: 898 HSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQ 954
Query: 954 DQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLM 1012
+Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLM
Sbjct: 955 EQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLM 1014
Query: 1013 LLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEV 1072
LLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEV
Sbjct: 1015 LLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEV 1074
Query: 1073 EKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLP 1132
EKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL
Sbjct: 1075 EKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQ 1134
Query: 1133 HRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNT 1192
H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP T
Sbjct: 1135 HKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKT 1194
Query: 1193 DGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVET 1252
DGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVET
Sbjct: 1195 DGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVET 1254
Query: 1253 GHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
GHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1255 GHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1305
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 1584 bits (4101), Expect = 0.0
Identities = 872/1363 (63%), Positives = 997/1363 (73%), Gaps = 155/1363 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
Query: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Q +Q+Q R VE++ PL
Sbjct: 476 HQ-------RQEQ---------------------------RPVEKK---------PLYHY 492
Query: 541 KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQ 600
K G + P ++P +E PH V +K + SQ
Sbjct: 493 KEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPALTASQ 525
Query: 601 SLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NP 654
S+ +QPT+ L+ F + + S R + RQNSDPTSE P P P +
Sbjct: 526 SVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDR 574
Query: 655 PAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSDPGW 707
+W+R + + PPKVPQRT+SI+ AL N S G +Q +RASNPDLRR++P
Sbjct: 575 SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL 634
Query: 708 ER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-PGNK 749
E S S P+S G P QAGS ER RV +SK + SPVL K
Sbjct: 635 ESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAK 694
Query: 750 AKPDDHR--SRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVESSEDD 807
KP++ R +RP RPA E L+E ++E RP KK DYSSSSEE ESSE++
Sbjct: 695 VKPEESRDITRPSRPADLTALAKE----LRELRIEETNRPMKKVTDYSSSSEESESSEEE 750
Query: 808 EEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG----- 854
EE+GE +G+ D P G + +V + H +E T + G
Sbjct: 751 EEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISRE 808
Query: 855 GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSG 906
GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S++ SG
Sbjct: 809 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 868
Query: 907 DYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DV 960
G + K+SFT FVD +YQ + + AL E R +Q + +
Sbjct: 869 TEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEA 925
Query: 961 RKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 1020
RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG
Sbjct: 926 RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQG 985
Query: 1021 KVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTT 1080
KVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW T
Sbjct: 986 KVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWIT 1045
Query: 1081 VGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDL 1140
VGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDL
Sbjct: 1046 VGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDL 1105
Query: 1141 TVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLC 1200
TVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+C
Sbjct: 1106 TVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVC 1165
Query: 1201 YEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFM 1260
YEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFM
Sbjct: 1166 YEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFM 1225
Query: 1261 HKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
HKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1226 HKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1268
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 1578 bits (4086), Expect = 0.0
Identities = 868/1367 (63%), Positives = 1000/1367 (73%), Gaps = 134/1367 (9%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEE-QRQSERLQRQLQQEHAYLKSL 479
QE+EQ+R E+ +RREEERR+AE EQEY R+QLEE QRQ E LQ+QL E A L
Sbjct: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 480 QQQQQQQQLQKQQQQQLLPGDRK---PLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
+++Q ++Q Q ++ Q+ L +R L H + P +K P
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK------------------KP 517
Query: 537 LAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPV 596
L K G + P ++P +E PH V +K +
Sbjct: 518 LYHYKEGMS---------------------PSEKPAWAKEIPHL------VAVKSQGPAL 550
Query: 597 PRSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP---- 652
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 551 TASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIE 599
Query: 653 --NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRS 703
+ +W+R + + PPKVPQRT+SI+ AL N S G +Q +RASNPDLRR+
Sbjct: 600 KFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRT 659
Query: 704 DPGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS- 745
+P E S S P+S G P QAGS ER RV +SK + SPVL
Sbjct: 660 EPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPH 719
Query: 746 PGNKAKPDDHR--SRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVES 803
K KP++ R +RP RPA E L+E ++E RP KK DYSSSSEE ES
Sbjct: 720 EPAKVKPEESRDITRPSRPADLTALAKE----LRELRIEETNRPMKKVTDYSSSSEESES 775
Query: 804 SEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG- 854
SE++EE+GE +G+ D P G + +V + H +E T + G
Sbjct: 776 SEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGS 833
Query: 855 ----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD 903
GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S S++
Sbjct: 834 ISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQE 893
Query: 904 -GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQ 957
SG G + K+SFT FVD +YQ + + AL E R +Q +
Sbjct: 894 MDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAK 950
Query: 958 Y-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 1016
+ RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR
Sbjct: 951 LNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDR 1010
Query: 1017 SGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQ 1076
SGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQ
Sbjct: 1011 SGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQ 1070
Query: 1077 GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPL 1136
GW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PL
Sbjct: 1071 GWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPL 1130
Query: 1137 LVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGME 1196
LVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TDGME
Sbjct: 1131 LVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGME 1190
Query: 1197 MLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLD 1256
ML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLD
Sbjct: 1191 MLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLD 1250
Query: 1257 GVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
GVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1251 GVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1297
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 1547 bits (4006), Expect = 0.0
Identities = 865/1389 (62%), Positives = 981/1389 (70%), Gaps = 155/1389 (11%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 420 KLQEKEQQRR-------LEDMQALRREEE--------RRQAEREQEYKRKQLEEQ----- 459
+ QE+EQ+RR LE+++ R+EEE +R+ EREQEY R+QLEE+
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 460 ------------------------RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495
RQ+ERLQRQLQQE AYL SLQ ++ Q QQ
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
Query: 496 LLPGDR-KPLYHYGRGM---NPADKPAWAREVEERTRMNKQQNSPLAKSKPGSTGPEPPI 551
+R KP +H PAD+ AREVE+R R +SP A+SK EPP+
Sbjct: 541 PPQQERSKPSFHAPEPKAHYEPADR---AREVEDRFRKTNH-SSPEAQSKQTGRVLEPPV 596
Query: 552 PQASPGPPGPLSQT--PPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRN 609
P S S++ P +QRP EPQ +H LK +PV RS S D +
Sbjct: 597 PSRSESFSNGNSESVHPALQRPAEPQVQ-----WSHLASLKNNVSPVSRSHSFSDPSPKF 651
Query: 610 LAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVRPDN-EAPPKV 668
S DP P +R V+ Q+SD SE P P+ AW R D+ E PP+V
Sbjct: 652 AHHHLRSQDP---------CPPSRSEVLSQSSDSKSEAPDPTQK--AWSRSDSDEVPPRV 700
Query: 669 PQRTSSIATALNTSGA----GGSRPAQAVRASNPDLRRSDPGWERSDSVLP--------- 715
P RT+S + L+ + G + +QA + ++ WER + ++P
Sbjct: 701 PVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSG 760
Query: 716 -ASHGHLP------QAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS--RPGRPASY 765
++ G P Q+GS ER RV SSK + SP N K P+D + RP +PA
Sbjct: 761 SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 820
Query: 766 KRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGGPAEGSRD 821
L KE E RPP K DYSSSSEE E +D E+EG G D
Sbjct: 821 VDLTA----LAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPED 876
Query: 822 TPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHADSNGY 877
T S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 877 TRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA------------ 924
Query: 878 TNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSG 937
S L K SSFT F+D + Q S
Sbjct: 925 --------------------------------SSTLQKHKSSSSFTPFIDPRLLQISPSS 952
Query: 938 DSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEIL 994
+ +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKYKKRFNSEIL
Sbjct: 953 GTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEIL 1011
Query: 995 CAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLR 1054
CAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK++KLR
Sbjct: 1012 CAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLR 1071
Query: 1055 VYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAW 1114
VYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKSSVEVYAW
Sbjct: 1072 VYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAW 1131
Query: 1115 APKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIP 1174
APKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+ YDIY+P
Sbjct: 1132 APKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLP 1191
Query: 1175 VHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICS 1234
HIQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI S
Sbjct: 1192 THIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRS 1251
Query: 1235 NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT 1294
NQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT
Sbjct: 1252 NQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT 1311
Query: 1295 LNRNCIMNW 1303
L R +++W
Sbjct: 1312 LGRTSLLSW 1320
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 1467 bits (3798), Expect = 0.0
Identities = 815/1338 (60%), Positives = 937/1338 (70%), Gaps = 161/1338 (12%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479
+ QE+EQ+RR +EE+R+ E E E +RK+ EE+R++E +R++++E Y++
Sbjct: 421 RQQEREQRRR--------EQEEKRRLE-ELERRRKEEEERRRAEEEKRRVEREQEYIR-- 469
Query: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK 539
+Q +++Q+ + QQQLL L+ + R
Sbjct: 470 RQLEEEQRHLEVLQQQLLQEQAMLLHDHRR------------------------------ 499
Query: 540 SKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRS 599
P PQ S PP PP Q +P H K + P R+
Sbjct: 500 ----------PHPQHSQQPP------PPQQERSKPS--------FHAPEPKAHYEPADRA 535
Query: 600 QSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVR 659
+ ++D+ + + P + PS + NS+ PA R
Sbjct: 536 REVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVH---------PALQR 586
Query: 660 PDNEAPPKVPQRTSSIATALNTSGA----GGSRPAQAVRASNPDLRRSDPGWERSDSVLP 715
P A P+VP RT+S + L+ + G + +QA + ++ WER + ++P
Sbjct: 587 P---AEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVP 643
Query: 716 ----------ASHGHLP------QAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS- 757
++ G P Q+GS ER RV SSK + SP N K P+D +
Sbjct: 644 RPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEV 703
Query: 758 -RPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGE 812
RP +PA L KE E RPP K DYSSSSEE E +D E+EG
Sbjct: 704 FRPLKPAGEVDLTA----LAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGA 759
Query: 813 GGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERN 868
G DT S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 760 DESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA--- 816
Query: 869 LLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDL 928
S L K SSFT F+D
Sbjct: 817 -----------------------------------------SSTLQKHKSSSSFTPFIDP 835
Query: 929 GIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKY 985
+ Q S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKY
Sbjct: 836 RLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKY 894
Query: 986 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLIT 1045
KKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+T
Sbjct: 895 KKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVT 954
Query: 1046 ISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIAL 1105
ISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIAL
Sbjct: 955 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL 1014
Query: 1106 KSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDS 1165
KSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDS
Sbjct: 1015 KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS 1074
Query: 1166 GNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEM 1225
G+ YDIY+P HIQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEM
Sbjct: 1075 GSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEM 1134
Query: 1226 PTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG 1285
PTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG
Sbjct: 1135 PTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG 1194
Query: 1286 GSSQVYFMTLNRNCIMNW 1303
GSSQVYFMTL R +++W
Sbjct: 1195 GSSQVYFMTLGRTSLLSW 1212
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 791 bits (2044), Expect = 0.0
Identities = 418/566 (73%), Positives = 465/566 (82%), Gaps = 33/566 (5%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 420 KLQEKEQ-------QRRLEDMQALRR--------EEERRQAEREQEYKRKQL-EEQRQSE 463
+ QE+EQ +RRLE+++ R+ EEE+R+ EREQEY R+QL EEQR E
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 464 RLQRQLQQEHAYLKSLQQQ---QQQQQLQKQQQQQLLPGDR--KPLYHYGRGMNPADKPA 518
LQ+QL QE A L ++ Q QQ QQ++ P +P HY PAD+
Sbjct: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHY----EPADR-- 534
Query: 519 WAREVEERTRMN----KQQNSPLAKS 540
AREV RT +++SPL S
Sbjct: 535 -AREVPVRTTSRSPVLSRRDSPLQGS 559
Score = 715 bits (1845), Expect = 0.0
Identities = 454/988 (45%), Positives = 569/988 (57%), Gaps = 142/988 (14%)
Query: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIK-HLLHQRQRRIEEQK---------EERRRVEE 410
+ S + LK Q +R +K H+ R++R E+ + EE V E
Sbjct: 276 QRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPE 335
Query: 411 QQRR---------EREQRKLQEKEQQRRLEDMQALRREE--ERRQAEREQEYKRKQLEEQ 459
Q+ E R+ + QQ E +ALRR++ + +Q ++EYKR+ L E+
Sbjct: 336 QEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAER 395
Query: 460 RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAW 519
++ R+++Q +Q + +++++ ++ Q+++Q++ +++ L R ++
Sbjct: 396 QK--RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEE--- 450
Query: 520 AREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPH 579
R EE R +++ + + + Q L Q M
Sbjct: 451 RRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQ-------LLQEQAML---------- 493
Query: 580 KSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDP-DPAIPAPTATPSARGAVIR 638
L HR P ++ P Q + +P+ + A ++P D A P T S R V+
Sbjct: 494 --LHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTS-RSPVLS 550
Query: 639 QNSDPTSEGPGPSPNPPAWVRPDNEAPPKVP-QRTSSIATALNTSGAGGSRPAQAVRASN 697
+ P +G G + + P++ +R + + + GS + + S+
Sbjct: 551 RRDSPL-QGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSH 609
Query: 698 PDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHR 756
P Q+GS ER RV SSK + SP N K P+D +
Sbjct: 610 PG----------------------SQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKK 647
Query: 757 S--RPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEE 810
RP +PA L KE E RPP K DYSSSSEE E +D E+E
Sbjct: 648 EVFRPLKPAGEVDLTA----LAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE 703
Query: 811 GEGGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEE 866
G G DT S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 704 GADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA- 762
Query: 867 RNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFV 926
S L K SSFT F+
Sbjct: 763 -------------------------------------------SSTLQKHKSSSSFTPFI 779
Query: 927 DLGIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIR 983
D + Q S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIR
Sbjct: 780 DPRLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIR 838
Query: 984 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1043
KYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L
Sbjct: 839 KYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVL 898
Query: 1044 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1103
+TISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVI
Sbjct: 899 VTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVI 958
Query: 1104 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1163
ALKSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDV
Sbjct: 959 ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV 1018
Query: 1164 DSGNSYDIYIPVH--------IQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRII 1215
DSG+ YDIY+P H IQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI
Sbjct: 1019 DSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT 1078
Query: 1216 KDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND 1275
KDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND
Sbjct: 1079 KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND 1138
Query: 1276 KVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
KVFFASVRSGGSSQVYFMTL R +++W
Sbjct: 1139 KVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
>gi|118600963 Nik related kinase [Homo sapiens]
Length = 1582
Score = 405 bits (1041), Expect = e-112
Identities = 244/601 (40%), Positives = 340/601 (56%), Gaps = 74/601 (12%)
Query: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M P R + DL L DP GIF L + +G GTYG++Y G H KTG A+KVM+ +
Sbjct: 1 MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
Query: 61 ------------------------DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPG 96
DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG
Sbjct: 61 TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
Query: 97 NDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKG 156
QLW+VME C AGSVTD+V+ T +LKED IAYICREIL+GLAHLHAH+VIHRDIKG
Sbjct: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
Query: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDI 216
QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P +YDYRSD+
Sbjct: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
Query: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLS 276
WS+GITAIEMAEGAPPLC++ P+ ALF+I R P +KS WS+KF +F++ C IK +L
Sbjct: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
Query: 277 RPPTEQLLKFPFIRDQPTERQVRIQLKDH---IDRSRKKRG-----EKEET-EYEYSGSE 327
RP + +L+ PF+RD ER V L H I + R+K+G E+EE + +Y+
Sbjct: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
Query: 328 EEDDS--------------------HGEEGEP-----------SSIMNVPGESTLRREFL 356
S HGE +P ++ + G + R F+
Sbjct: 361 FRGPSCTHELLRLPTSSRCRPLRVLHGEPSQPRWLPDREEPQVQALQQLQGAA---RVFM 417
Query: 357 RLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRRER 416
LQ + S + LK Q Q Q+ Q + Q Q + + K + +++ R R
Sbjct: 418 PLQALD-SAPKPLKGQAQAPQRLQGAARVFMP---LQAQVKAKASKPLQMQIKAPPRLRR 473
Query: 417 EQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYL 476
R L + Q R + ++ + ++Q + Q + + L++ + + Q Q+ ++
Sbjct: 474 AARVLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQRQG 533
Query: 477 KSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSP 536
++ +QQQ+ Q+ +Q+ +Q ++ + + PA A E E R+N Q P
Sbjct: 534 QAPEQQQRHNQVPEQELEQNQAPEQPEVQE--QAAEPAQAETEAEE-PESLRVNAQVFLP 590
Query: 537 L 537
L
Sbjct: 591 L 591
Score = 282 bits (721), Expect = 2e-75
Identities = 186/589 (31%), Positives = 287/589 (48%), Gaps = 76/589 (12%)
Query: 783 EAPRPPKKAM--DYSSSSEEVESSEDDEEEGEG-GPAEGSRDTPGGRSDGDTDSVSTMVV 839
EAP P+ + D S + + S EE G G +R G + D ++
Sbjct: 986 EAPSCPRASYGRDGSCKQDGYDGSRGKEEAYRGYGSHTANRSHGGSAASEDNAAIGDQEE 1045
Query: 840 HDVEEITGTQPPYGGGTMVVQRTPEEERNL-LHADSN-GYTNLPDVVQPSHSPTENSKGQ 897
H + + G G V RT EE L L+ + N T+ P + +P+ E + +
Sbjct: 1046 HAANIGSERRGSEGDGGKGVVRTSEESGALGLNGEENCSETDGPGLKRPASQDFEYLQEE 1105
Query: 898 SPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQP-------------GGSGDSIPITA 944
+ S S AP S + Q G S D+ +A
Sbjct: 1106 PGGGNEASNAIDSGAAPSAPDHESDNKDISESSTQSDFSANHSSPSKGSGMSADANFASA 1165
Query: 945 LVGGEGTRLDQLQYDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLL 1004
++ + + ++ S VNVNP + P I Y+K F SEI C +LWGVNLL
Sbjct: 1166 ILYAGFVEVPE--ESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGSLWGVNLL 1223
Query: 1005 VGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNK 1064
+GT + L L+DRSG+ + LI RR F+Q+ VLE LNLLITISG +N+LRVY+L+WLRNK
Sbjct: 1224 LGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYHLTWLRNK 1283
Query: 1065 ILHNDPEVEKKQ--------GWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAP 1116
IL+NDPE +++Q + + GC H+ V+++E ++ IALKSS+ +YAWAP
Sbjct: 1284 ILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSIHLYAWAP 1343
Query: 1117 K---------------------------------------PYHKF---------MAFKSF 1128
K P ++F + K F
Sbjct: 1344 KSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLHLLKLKVF 1403
Query: 1129 ADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIF 1188
L H+P+ VDL + +RLK+ + S+ G+H +D +S D+ +P + I P II
Sbjct: 1404 PTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEIIIPQNIII 1463
Query: 1189 LPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIR 1248
LP+ G+ M+L + E + V ++ K ++ W ++P+S+A+ C+ + GWG+KAIE+R
Sbjct: 1464 LPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWGQKAIEVR 1523
Query: 1249 SVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNR 1297
S+++ L+ + ++L+FLC R DK+FF S S+VYFMTL +
Sbjct: 1524 SLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
Score = 42.7 bits (99), Expect = 0.002
Identities = 46/230 (20%), Positives = 97/230 (42%), Gaps = 36/230 (15%)
Query: 351 LRREFLRLQQENKSNSEALKQQQQL-----------QQQQQRDPEAHIKHLLHQRQRRIE 399
L R+ LR N +NS+ L Q L Q +Q R+ ++ + L +R+
Sbjct: 643 LSRDLLRAP--NSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
Query: 400 EQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQ 459
++ + ++ E + + + +QRR ED+ + EEE RQ ++++E + +E
Sbjct: 701 PKRFRAKSSWRPEKLELSDLEARRQRRQRRWEDI-FNQHEEELRQVDKDKEDESSDNDEV 759
Query: 460 RQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRG--------M 511
S + + Q++ Y+ + ++++ Q++ +P ++ +H +
Sbjct: 760 FHSIQAEVQIEPLKPYISN------PKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLL 813
Query: 512 NPADKPAWAREVEERTRMN--------KQQNSPLAKSKPGSTGPEPPIPQ 553
A KP R+ + R N ++ SP+ + S+ P I Q
Sbjct: 814 EQAQKPIDIRQRSSQNRQNWLAASESSSEEESPVTGRRSQSSPPYSTIDQ 863
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 310 bits (793), Expect = 8e-84
Identities = 153/273 (56%), Positives = 189/273 (69%), Gaps = 4/273 (1%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHH 79
DP+ +E+ E +G GTYG+V+K + K GQ AA+K++D D +EEI+ E N+LK S H
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 80 RNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKN--TKGNALKEDCIAYICREI 137
N+ +YG + KK N D+LWLV+E C GSVTDLVK +G + E IAYI E
Sbjct: 76 PNVVRFYGIYFKKDKV-NGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L GL HLH +K IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVIAC++ D TYD R D WSLGITAIE+ +G PPL D+HPMRALF IPRNPPP+L+ +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254
Query: 258 -WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
WS +F DFI CL K Y RP +LL+ FI
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFI 287
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 292 bits (747), Expect = 2e-78
Identities = 156/327 (47%), Positives = 206/327 (62%), Gaps = 11/327 (3%)
Query: 13 IDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK--GNALKEDCI 130
L+ +H N+ +YG F K QLWLV+E C GSVT+LVK G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHCVGG-QLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250
TP+WMAPEVIAC++ D++YD R D+WSLGITAIE+ +G PPL DMHP++ LF IPRNPP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP-----TERQVRIQLKD 304
P L +KW ++F FI CLIK + RP LL PFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRSRKKRGEKEETEYEYSGSEEE 329
H + K R E+ T Y + E
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAE 340
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 292 bits (747), Expect = 2e-78
Identities = 156/327 (47%), Positives = 206/327 (62%), Gaps = 11/327 (3%)
Query: 13 IDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTK--GNALKEDCI 130
L+ +H N+ +YG F K QLWLV+E C GSVT+LVK G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHCVGG-QLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPP 250
TP+WMAPEVIAC++ D++YD R D+WSLGITAIE+ +G PPL DMHP++ LF IPRNPP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQP-----TERQVRIQLKD 304
P L +KW ++F FI CLIK + RP LL PFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRSRKKRGEKEETEYEYSGSEEE 329
H + K R E+ T Y + E
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAE 340
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 264 bits (675), Expect = 4e-70
Identities = 146/345 (42%), Positives = 214/345 (62%), Gaps = 20/345 (5%)
Query: 6 PARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
P R L +D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
Query: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNA 124
IK+ M + S H + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
Query: 125 LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFL 244
RNT IGTP+WMAPEVI + Y+ +DIWSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 245 IPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLK 303
IP NPPP K + WS F DF+ CL+K+ R QLL+ PF+R + + V I L+
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR---SAKGVSI-LR 291
Query: 304 DHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGE 348
D I+ + + +++E++ ++E++S +E + +++ G+
Sbjct: 292 DLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD 336
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 262 bits (669), Expect = 2e-69
Identities = 156/378 (41%), Positives = 223/378 (58%), Gaps = 39/378 (10%)
Query: 14 DLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINML 73
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
Query: 74 KKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYI 133
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
Query: 134 CREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
RE L+GL +LH+ +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
Query: 194 WMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPP 251
WMAPEV A + Y+ D+W++GITAIE+AE PP+ D+HPMRALFL+ ++ PP
Sbjct: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
Query: 252 RLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSR 310
+LK K KWS F F+ L K RP E+LL+ PF+ T R + I+L D ++
Sbjct: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLT-RSLAIELLDKVNNP- 292
Query: 311 KKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPG--ESTLRREFLRLQQENKSNSEA 368
++S + DD +P ++ VP ST R +E K+ SE
Sbjct: 293 -----------DHSTYHDFDDD-----DPEPLVAVPHRIHSTSRN-----VREEKTRSEI 331
Query: 369 LKQQQQLQQQQQRDPEAH 386
Q + +++ E H
Sbjct: 332 TFGQVKFDPPLRKETEPH 349
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 257 bits (657), Expect = 4e-68
Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)
Query: 5 APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
AP R DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 3 APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
Query: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
I+QEI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 60 SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
Query: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
L E IAY+CRE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
+R +FIGTPYWMAPEV A ++N Y+ DIW++GITAIE+ E PP+ D+HPMRALF
Sbjct: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
Query: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
L+ ++ PP+LK K KWS F +F+ L K RP E+LL F+ R + +
Sbjct: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
Query: 301 QLKDHID 307
+L D ++
Sbjct: 289 ELLDKVN 295
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 257 bits (657), Expect = 4e-68
Identities = 140/307 (45%), Positives = 200/307 (65%), Gaps = 18/307 (5%)
Query: 5 APARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEE 63
AP R DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 3 APLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDF 59
Query: 64 EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGN 123
I+QEI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 60 SLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--G 110
Query: 124 ALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
L E IAY+CRE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALF 243
+R +FIGTPYWMAPEV A ++N Y+ DIW++GITAIE+ E PP+ D+HPMRALF
Sbjct: 171 KRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALF 228
Query: 244 LIPRN--PPPRLKSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
L+ ++ PP+LK K KWS F +F+ L K RP E+LL F+ R + +
Sbjct: 229 LMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAV 288
Query: 301 QLKDHID 307
+L D ++
Sbjct: 289 ELLDKVN 295
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 256 bits (655), Expect = 8e-68
Identities = 145/329 (44%), Positives = 203/329 (61%), Gaps = 23/329 (6%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
DP +F ++ +G G++G+VYKG T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
I Y+G+++K + +LW++ME+ G GS DL+K L+E IA I REI
Sbjct: 75 SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH+ + IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD+++DIWSLGITAIE+A+G PP D+HPMR LFLIP+N PP L+ +
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
SK F +F++ CL K RP ++LLK FI + +L D R KR + E
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELID-----RYKRWKSE 293
Query: 318 ETEYEYSGSEEEDDSHGEEGEPSSIMNVP 346
E S + + D E+GE I P
Sbjct: 294 GHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 256 bits (653), Expect = 1e-67
Identities = 143/334 (42%), Positives = 204/334 (61%), Gaps = 18/334 (5%)
Query: 4 PAPARSLDDIDLSAL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDE 62
PAP L + +L + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 5 PAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDL 64
Query: 63 EEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKG 122
+E IK EI+++++ + YYG++ K + LW+VME+CGAGSV+D+++ +
Sbjct: 65 QEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRN 115
Query: 123 NALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
L ED IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 116 KTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTM 175
Query: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRAL 242
+RNT IGTP+WMAPEVI + Y+ +DIWSLGIT+IEMAEG PP D+HPMRA+
Sbjct: 176 AKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAI 230
Query: 243 FLIPRNPPPRL-KSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQ 301
F+IP NPPP K + WS F DF+ CL+K R QLL+ PFI++ +R
Sbjct: 231 FMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL 290
Query: 302 LKD--HIDRSRKKRGEKEETEYEYSGSEEEDDSH 333
+ + I R + ++E E E + E+E DSH
Sbjct: 291 ITEAMEIKAKRHEEQQRELEEEEENSDEDELDSH 324
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 253 bits (646), Expect = 8e-67
Identities = 150/383 (39%), Positives = 226/383 (59%), Gaps = 39/383 (10%)
Query: 18 LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKK 75
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+QEI +L +
Sbjct: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
Query: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
+ YYG+++K S +LW++ME+ G GS DL++ E IA + +
Sbjct: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
Query: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
EIL+GL +LH+ K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
Query: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKS 255
APEVI + YD ++DIWSLGITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
Query: 256 KKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGE 315
++K F +FID CL K RP ++LLK FI + +L D R + +
Sbjct: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
Query: 316 KEETEYEYSGSE---EEDDSHGE--------EGEPSSIMNVPGESTLRR----------E 354
+E++ E S SE E+++H E + +P + N + ++
Sbjct: 301 DDESDSEGSDSESTSRENNTHPEWSFTTVRKKPDPKKVQNGAEQDLVQTLSCLSMIITPA 360
Query: 355 FLRLQQENKSNSEALKQQQQLQQ 377
F L+Q++++N+ + ++L++
Sbjct: 361 FAELKQQDENNASRNQAIEELEK 383
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 249 bits (637), Expect = 9e-66
Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH+ K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++DIWSLGITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 189 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 242
Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
+SK +F++ CL K RP ++LLK FI + +L IDR ++ + E+
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 299
Query: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
+ S+ E D G S
Sbjct: 300 HDDSSSEDSDAETDGQASGGSDS 322
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 249 bits (637), Expect = 9e-66
Identities = 140/323 (43%), Positives = 199/323 (61%), Gaps = 21/323 (6%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+QEI +L +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 78 HHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 91 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140
Query: 138 LRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH+ K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200
Query: 198 EVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++DIWSLGITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 201 EVI-----KQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG-N 254
Query: 258 WSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKE 317
+SK +F++ CL K RP ++LLK FI + +L IDR ++ + E+
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQS 311
Query: 318 ETEYEYSGSEEEDDSHGEEGEPS 340
+ S+ E D G S
Sbjct: 312 HDDSSSEDSDAETDGQASGGSDS 334
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 243 bits (621), Expect = 7e-64
Identities = 139/326 (42%), Positives = 196/326 (60%), Gaps = 17/326 (5%)
Query: 17 ALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKQEINMLKK 75
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++QEI +L++
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
Query: 76 YSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICR 135
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
Query: 136 EILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
E L+GL HLH+ IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
Query: 196 APEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
Query: 254 KSK-KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKK 312
+ K +W++ F F+ L K RP E+LL+ PF Q R + QL D
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
Query: 313 RGEKEETEYE-YSGSEEEDDSHGEEG 337
E+ E E Y + S G+ G
Sbjct: 296 TPSPEDCELETYDMFPDTIHSRGQHG 321
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 242 bits (618), Expect = 1e-63
Identities = 146/375 (38%), Positives = 213/375 (56%), Gaps = 27/375 (7%)
Query: 19 RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSH 78
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
Query: 79 HRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREIL 138
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
Query: 139 RGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
+GLA+LH+ K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
Query: 199 VIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLKSK 256
V A Y+ DIWSLGITAIE+AE PPL D+HP+R LFL+ ++ PPRLK K
Sbjct: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
Query: 257 -KWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRG- 314
KWS F +FI L K+ RP ++L + R + + L D + K
Sbjct: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
Query: 315 ---EKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRR--EFLRL---QQENKSNS 366
E EE E + +H SS + +P RR EF +L + +N+
Sbjct: 301 GDIEDEEPELPPAIPRRIRSTH-----RSSSLGIPDADCCRRHMEFRKLRGMETRPPANT 355
Query: 367 EALKQQQQLQQQQQR 381
L+ + L+ R
Sbjct: 356 ARLQPPRDLRSSSPR 370
Score = 33.1 bits (74), Expect = 1.8
Identities = 36/135 (26%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 1002 NLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWL 1061
+LL+G E G+ +L+R+ Q ++ R + + N+L+++SGK L + + L
Sbjct: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
Query: 1062 --------RNKILHNDPE---VEKKQGWTTVGDMEGCGHYRVVKYERI--KFLVIALKSS 1108
N I H P K T + D +GC V + FL AL++S
Sbjct: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
Query: 1109 VEVYAWAPKPYHKFM 1123
V + W +P +KF+
Sbjct: 631 VVLLQWY-QPMNKFL 644
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.133 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,996,370
Number of Sequences: 37866
Number of extensions: 3489916
Number of successful extensions: 79166
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1665
Number of HSP's successfully gapped in prelim test: 2338
Number of HSP's that attempted gapping in prelim test: 20045
Number of HSP's gapped (non-prelim): 23545
length of query: 1303
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1189
effective length of database: 13,930,794
effective search space: 16563714066
effective search space used: 16563714066
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.