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Search of human proteins with 121583542
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|121583542 mitogen-activated protein kinase kinase kinase 15
[Homo sapiens]
(788 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [... 1591 0.0
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom... 868 0.0
gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Ho... 632 0.0
gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo sa... 200 5e-51
gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo sa... 200 5e-51
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso... 172 1e-42
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso... 172 1e-42
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H... 169 7e-42
gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Ho... 167 5e-41
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 163 7e-40
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 163 7e-40
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 141 2e-33
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 140 3e-33
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 140 5e-33
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 140 5e-33
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 140 5e-33
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 140 5e-33
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 140 5e-33
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 140 5e-33
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 140 5e-33
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 140 5e-33
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 140 5e-33
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 140 6e-33
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 140 6e-33
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 140 6e-33
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 139 8e-33
gi|32483399 p21-activated kinase 2 [Homo sapiens] 139 1e-32
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 139 1e-32
gi|93004081 polo-like kinase 2 [Homo sapiens] 138 2e-32
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 138 2e-32
>gi|121583542 mitogen-activated protein kinase kinase kinase 15
[Homo sapiens]
Length = 788
Score = 1591 bits (4119), Expect = 0.0
Identities = 788/788 (100%), Positives = 788/788 (100%)
Query: 1 MACLTHRNETDARMEFYSLFHKGNKAGVQWHDLGSLQPLPPRFKRFSCLSLQSSWDYSLS 60
MACLTHRNETDARMEFYSLFHKGNKAGVQWHDLGSLQPLPPRFKRFSCLSLQSSWDYSLS
Sbjct: 1 MACLTHRNETDARMEFYSLFHKGNKAGVQWHDLGSLQPLPPRFKRFSCLSLQSSWDYSLS 60
Query: 61 KFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEY 120
KFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEY
Sbjct: 61 KFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEY 120
Query: 121 EYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLK 180
EYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLK
Sbjct: 121 EYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLK 180
Query: 181 HRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLH 240
HRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLH
Sbjct: 181 HRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLH 240
Query: 241 ENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGP 300
ENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGP
Sbjct: 241 ENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGP 300
Query: 301 RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI 360
RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI
Sbjct: 301 RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI 360
Query: 361 LSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSS 420
LSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSS
Sbjct: 361 LSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSS 420
Query: 421 SEHGSVSPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLL 480
SEHGSVSPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLL
Sbjct: 421 SEHGSVSPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLL 480
Query: 481 RKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHR 540
RKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHR
Sbjct: 481 RKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHR 540
Query: 541 VMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQ 600
VMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQ
Sbjct: 541 VMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQ 600
Query: 601 AAVTILIPELRAHFEPTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQ 660
AAVTILIPELRAHFEPTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQ
Sbjct: 601 AAVTILIPELRAHFEPTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQ 660
Query: 661 ETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELI 720
ETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELI
Sbjct: 661 ETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELI 720
Query: 721 DWLRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQE 780
DWLRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQE
Sbjct: 721 DWLRLQGADAKTIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQE 780
Query: 781 ASETKDKA 788
ASETKDKA
Sbjct: 781 ASETKDKA 788
>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
sapiens]
Length = 1374
Score = 868 bits (2243), Expect = 0.0
Identities = 458/766 (59%), Positives = 564/766 (73%), Gaps = 49/766 (6%)
Query: 58 SLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDT 117
S+SKF+ERCCFLYV NSDDFQIYF TE C +FF +V IT G + E EG+ + D
Sbjct: 613 SISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNT-ITEEKGRSTE-EGDCESDL 670
Query: 118 LEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHK 177
LEY+Y++D NG+RVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHK
Sbjct: 671 LEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHK 730
Query: 178 YLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMK--EPTIKFYTKQILEG 235
+LKH+NIVQYLGS SENG+IKIFMEQVPGGSLSALLRSKWGP+K E TI FYTKQILEG
Sbjct: 731 HLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEG 790
Query: 236 LKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEI 295
LKYLH+NQIVHRDIKGDNVL+NTYSGV+KISDFGTSKRLAG+NPCTETFTGTLQYMAPEI
Sbjct: 791 LKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEI 850
Query: 296 IDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAE 355
ID+GPRGYG ADIWSLGCTIIEMAT KPPF+ELGEPQAAMFKVGMFK+HPEIPE++SAE
Sbjct: 851 IDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAE 910
Query: 356 ARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNR-----IAFKPSEGPRGVVLALP 410
A+AFIL CFEPDP KRA +LL + FL+ +K KK + ++ +E R + L +P
Sbjct: 911 AKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLPVP 970
Query: 411 TQGEPMATSSSEHGSVSPDSDAQPDALFERTRA----PRHHLG---HLLSVPDESSALED 463
E +SSSE+GSVSPD++ + D +TRA R G L +PDE+ ED
Sbjct: 971 VLVED-TSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGIPDEN--FED 1027
Query: 464 RGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHI 523
SPE++D G F+LRKDSERRA L++IL E+Q+++ NL E +AQ +EE L HI
Sbjct: 1028 HSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHI 1087
Query: 524 KQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLI 583
+I LR+F+RS + +++ATT+SKLK++LDFDS ISQ+ +VLFGFQDAVNK+LRNH I
Sbjct: 1088 TTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNI 1147
Query: 584 RPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDK---DMDEAEEGYPP---- 636
+PHWMFA+D+IIR+AVQ A+TIL+PELR HF E++ D+ D+++ E P
Sbjct: 1148 KPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEEQPSNQTV 1207
Query: 637 -------------------ATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKEREYQ 677
++ ++Q + L++QLG ++ ETNRLLE LV KE+E Q
Sbjct: 1208 RRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQ 1267
Query: 678 NLLRQTLEQKTQELYHLQLKLKSNCITENPA---GPYGQRT-DKELIDWLRLQGADAKTI 733
LL + +E+K QE+ HL+LK + I E P G T D EL DWLR+ GAD TI
Sbjct: 1268 ALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTI 1327
Query: 734 EKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQ 779
+ + E YTL D+L +T++DL+ LRLRGG+LC LW A+ +R Q
Sbjct: 1328 SRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQ 1373
>gi|45827809 mitogen-activated protein kinase kinase kinase 6 [Homo
sapiens]
Length = 1288
Score = 632 bits (1629), Expect = 0.0
Identities = 354/748 (47%), Positives = 467/748 (62%), Gaps = 55/748 (7%)
Query: 51 LQSSWDY--------SLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNT 102
+ SSW + S SK DERCCFLY + D Q+ F + C F L++ +TN
Sbjct: 564 IPSSWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNP 623
Query: 103 AGSTVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERD 162
+ E E G+ LE++Y++ GER+VLGKGTYG+VYAGRD +VRIAIKEIPERD
Sbjct: 624 DSTAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPERD 683
Query: 163 SRYSQPLHEEIALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMK- 221
SR+SQPLHEEIALH+ L+H+NIV+YLGS S+ GY+KIFME+VPGGSLS+LLRS WGP+K
Sbjct: 684 SRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGPLKD 743
Query: 222 -EPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPC 280
E TI FYT+QIL+GL YLH+N IVHRDIKGDNVL+NT+SG++KISDFGTSKRLAG+ PC
Sbjct: 744 NESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPC 803
Query: 281 TETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVG 340
TETFTGTLQYMAPEIIDQGPRGYG ADIWSLGCT+IEMAT +PPFHELG PQAAMF+VG
Sbjct: 804 TETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVG 863
Query: 341 MFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSE 400
M+K+HP +P +LSAEA+AF+L FEPDP RA+ LL + FL+ GK++R P
Sbjct: 864 MYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQ---PGKRSRSPSSPRH 920
Query: 401 GPR--GVVLALPTQGEPMATSSSEHGSVSPDSDAQPDALFERTRAPRHHLGH----LLSV 454
PR A PT T S S P P+ L + L V
Sbjct: 921 APRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPS-------PPKRCLSYGGTSQLRV 973
Query: 455 PDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSE 514
P+E +A E +SPE+ GL LL ++S+RRA+L +L +E +A NL + + +
Sbjct: 974 PEEPAAEE----PASPEE-SSGLSLLHQESKRRAMLAAVLEQELPALAENLHQ-EQKQEQ 1027
Query: 515 ELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAV 574
L H+++++ L I +P R +A + L+ L + +H LF F DAV
Sbjct: 1028 GARLGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAV 1087
Query: 575 NKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFEPTCETEGVDKDMDEAEEGY 634
+ILR IRPHWMF +D+++ RAV+AA+ +L PE+ E E V +E
Sbjct: 1088 KQILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEV--------EKEAVSPRSEELSNEG 1139
Query: 635 PPATGPGQEA----QPHQ--QHLSLQLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKT 688
PGQ++ +P Q L +QL LR ET+RL E L KEREYQ L+++ L++
Sbjct: 1140 DSQQSPGQQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLN 1199
Query: 689 QELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEKIVEEGYTLSDILN 748
+E L P P TD+ L+ WL+ D+ TI+ ++ +TL +L
Sbjct: 1200 EEARTYVLA---------PEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLT 1250
Query: 749 EITKEDLRYLRLRGGLLCRLWSAVSQYR 776
T++DL Y R+RGG++CR+W A+ R
Sbjct: 1251 YATRDDLIYTRIRGGMVCRIWRAILAQR 1278
>gi|68077164 Yeast Sps1/Ste20-related kinase 4 isoform 1 [Homo
sapiens]
Length = 1328
Score = 200 bits (508), Expect = 5e-51
Identities = 114/267 (42%), Positives = 168/267 (62%), Gaps = 19/267 (7%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDS------RYSQPLHEEIALHKYLKHRNIV 185
+LGKG YG VY G Q+ IA+K++ S + + L EE+ L K LKH NIV
Sbjct: 1066 ILGKGAYGTVYCGLTSQGQL-IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 1124
Query: 186 QYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIV 245
YLG+ + + IFME VPGGS+S+++ +++GP+ E YTKQIL+G+ YLHEN +V
Sbjct: 1125 AYLGTCLQENTVSIFMEFVPGGSISSII-NRFGPLPEMVFCKYTKQILQGVAYLHENCVV 1183
Query: 246 HRDIKGDNVLVNTYSGVVKISDFGTSKRLA--GVN----PCTETFTGTLQYMAPEIIDQG 299
HRDIKG+NV++ +G++K+ DFG ++RLA G+N ++ GT +MAPE+I++
Sbjct: 1184 HRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINES 1242
Query: 300 PRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFK-IHPEIPEALSAEARA 358
GYG +DIWS+GCT+ EMAT KPP + + AAMF +G + + P +P+ S A
Sbjct: 1243 --GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRGLMPPLPDHFSENAAD 1299
Query: 359 FILSCFEPDPHKRATTAELLREGFLRQ 385
F+ C D H+R + +LL+ FL +
Sbjct: 1300 FVRMCLTRDQHERPSALQLLKHSFLER 1326
>gi|63998898 Yeast Sps1/Ste20-related kinase 4 isoform 2 [Homo
sapiens]
Length = 510
Score = 200 bits (508), Expect = 5e-51
Identities = 114/267 (42%), Positives = 168/267 (62%), Gaps = 19/267 (7%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDS------RYSQPLHEEIALHKYLKHRNIV 185
+LGKG YG VY G Q+ IA+K++ S + + L EE+ L K LKH NIV
Sbjct: 248 ILGKGAYGTVYCGLTSQGQL-IAVKQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIV 306
Query: 186 QYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIV 245
YLG+ + + IFME VPGGS+S+++ +++GP+ E YTKQIL+G+ YLHEN +V
Sbjct: 307 AYLGTCLQENTVSIFMEFVPGGSISSII-NRFGPLPEMVFCKYTKQILQGVAYLHENCVV 365
Query: 246 HRDIKGDNVLVNTYSGVVKISDFGTSKRLA--GVN----PCTETFTGTLQYMAPEIIDQG 299
HRDIKG+NV++ +G++K+ DFG ++RLA G+N ++ GT +MAPE+I++
Sbjct: 366 HRDIKGNNVMLMP-TGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINES 424
Query: 300 PRGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFK-IHPEIPEALSAEARA 358
GYG +DIWS+GCT+ EMAT KPP + + AAMF +G + + P +P+ S A
Sbjct: 425 --GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRGLMPPLPDHFSENAAD 481
Query: 359 FILSCFEPDPHKRATTAELLREGFLRQ 385
F+ C D H+R + +LL+ FL +
Sbjct: 482 FVRMCLTRDQHERPSALQLLKHSFLER 508
>gi|42794767 mitogen-activated protein kinase kinase kinase 3
isoform 1 [Homo sapiens]
Length = 657
Score = 172 bits (435), Expect = 1e-42
Identities = 107/262 (40%), Positives = 151/262 (57%), Gaps = 18/262 (6%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEI------PERDSRYSQPLHEEIALHKYLKHRNIV 185
+LG+G +G VY D+ +A K++ PE S L EI L K L+H IV
Sbjct: 398 LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSA-LECEIQLLKNLQHERIV 456
Query: 186 QYLGSVSENGY--IKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQ 243
QY G + + + IFME +PGGS+ L++ +G + E + YT+QILEG+ YLH N
Sbjct: 457 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA-YGALTESVTRKYTRQILEGMSYLHSNM 515
Query: 244 IVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGV---NPCTETFTGTLQYMAPEIIDQGP 300
IVHRDIKG N+L ++ +G VK+ DFG SKRL + + TGT +M+PE+I
Sbjct: 516 IVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI--SG 572
Query: 301 RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI 360
GYG AD+WSLGCT++EM T KPP+ E E AA+FK+ +P++P +S R F+
Sbjct: 573 EGYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRDFL 631
Query: 361 LSCFEPDPHKRATTAELLREGF 382
F + +R + ELL F
Sbjct: 632 RRIF-VEARQRPSAEELLTHHF 652
>gi|42794765 mitogen-activated protein kinase kinase kinase 3
isoform 2 [Homo sapiens]
Length = 626
Score = 172 bits (435), Expect = 1e-42
Identities = 107/262 (40%), Positives = 151/262 (57%), Gaps = 18/262 (6%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEI------PERDSRYSQPLHEEIALHKYLKHRNIV 185
+LG+G +G VY D+ +A K++ PE S L EI L K L+H IV
Sbjct: 367 LLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSA-LECEIQLLKNLQHERIV 425
Query: 186 QYLGSVSENGY--IKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQ 243
QY G + + + IFME +PGGS+ L++ +G + E + YT+QILEG+ YLH N
Sbjct: 426 QYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKA-YGALTESVTRKYTRQILEGMSYLHSNM 484
Query: 244 IVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGV---NPCTETFTGTLQYMAPEIIDQGP 300
IVHRDIKG N+L ++ +G VK+ DFG SKRL + + TGT +M+PE+I
Sbjct: 485 IVHRDIKGANILRDS-AGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI--SG 541
Query: 301 RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI 360
GYG AD+WSLGCT++EM T KPP+ E E AA+FK+ +P++P +S R F+
Sbjct: 542 EGYGRKADVWSLGCTVVEMLTEKPPWAEY-EAMAAIFKIATQPTNPQLPSHISEHGRDFL 600
Query: 361 LSCFEPDPHKRATTAELLREGF 382
F + +R + ELL F
Sbjct: 601 RRIF-VEARQRPSAEELLTHHF 621
>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
sapiens]
Length = 1512
Score = 169 bits (429), Expect = 7e-42
Identities = 97/264 (36%), Positives = 146/264 (55%), Gaps = 15/264 (5%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIP------ERDSRYSQPLHEEIALHKYLKHRNIVQ 186
+G G + Y +D+ +A+K++ + L EEI + +L H NI++
Sbjct: 1249 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIR 1308
Query: 187 YLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVH 246
LG+ E +F+E + GGS++ LL SK+G KE + YT+Q+L GL YLHENQI+H
Sbjct: 1309 MLGATCEKSNYNLFIEWMAGGSVAHLL-SKYGAFKESVVINYTEQLLRGLSYLHENQIIH 1367
Query: 247 RDIKGDNVLVNTYSGVVKISDFGTSKRLA----GVNPCTETFTGTLQYMAPEIIDQGPRG 302
RD+KG N+L+++ ++I+DFG + RLA G GT+ +MAPE++ +G +
Sbjct: 1368 RDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL-RGQQ- 1425
Query: 303 YGAPADIWSLGCTIIEMATSKPPFH--ELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI 360
YG D+WS+GC IIEMA +KPP++ + A +FK+ P IP LS R
Sbjct: 1426 YGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVA 1485
Query: 361 LSCFEPDPHKRATTAELLREGFLR 384
L C E P R + ELL+ R
Sbjct: 1486 LRCLELQPQDRPPSRELLKHPVFR 1509
>gi|85838511 mitogen-activated protein kinase kinase kinase 2 [Homo
sapiens]
Length = 619
Score = 167 bits (422), Expect = 5e-41
Identities = 107/263 (40%), Positives = 153/263 (58%), Gaps = 18/263 (6%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEI------PERDSRYSQPLHEEIALHKYLKHRNIV 185
+LG+G +G VY D+ +A+K++ PE S+ L EI L K L H IV
Sbjct: 361 LLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPET-SKEVNALECEIQLLKNLLHERIV 419
Query: 186 QYLGSVSE--NGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQ 243
QY G + + + IFME +PGGS+ L++ +G + E + YT+QILEG+ YLH N
Sbjct: 420 QYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKA-YGALTENVTRKYTRQILEGVHYLHSNM 478
Query: 244 IVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGV---NPCTETFTGTLQYMAPEIIDQGP 300
IVHRDIKG N+L ++ +G VK+ DFG SKRL + ++ TGT +M+PE+I
Sbjct: 479 IVHRDIKGANILRDS-TGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI--SG 535
Query: 301 RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFI 360
GYG ADIWS+ CT++EM T KPP+ E E AA+FK+ +P++P +S R F+
Sbjct: 536 EGYGRKADIWSVACTVVEMLTEKPPWAEF-EAMAAIFKIATQPTNPKLPPHVSDYTRDFL 594
Query: 361 LSCFEPDPHKRATTAELLREGFL 383
F + R + ELLR F+
Sbjct: 595 KRIF-VEAKLRPSADELLRHMFV 616
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 163 bits (412), Expect = 7e-40
Identities = 103/259 (39%), Positives = 144/259 (55%), Gaps = 12/259 (4%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKYLKHRNIVQYLGS 190
+G+G YG VY + +A+KEI D + + +E+ + + +KH N+V+Y G
Sbjct: 1349 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1408
Query: 191 VSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIK 250
+ IFME G+L + R ++E I+ Y+KQI + LHE+ IVHRDIK
Sbjct: 1409 ELHREEMYIFMEYCDEGTLEEVSRLG---LQEHVIRLYSKQITIAINVLHEHGIVHRDIK 1465
Query: 251 GDNVLVNTYSGVVKISDFGTSKRL---AGVNPCTETFT-GTLQYMAPEIIDQGP-RGYGA 305
G N+ + T SG++K+ DFG S +L A P T GT YMAPE+I + G+G
Sbjct: 1466 GANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGR 1524
Query: 306 PADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFE 365
ADIWSLGC +IEM T K P+HE M+KVGM P IPE LS E + F+ C E
Sbjct: 1525 AADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKDFLSHCLE 1583
Query: 366 PDPHKRATTAELLREGFLR 384
DP R T ++LL F++
Sbjct: 1584 SDPKMRWTASQLLDHSFVK 1602
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 163 bits (412), Expect = 7e-40
Identities = 103/259 (39%), Positives = 144/259 (55%), Gaps = 12/259 (4%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEI--PERDSRYSQPLHEEIALHKYLKHRNIVQYLGS 190
+G+G YG VY + +A+KEI D + + +E+ + + +KH N+V+Y G
Sbjct: 1299 IGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGV 1358
Query: 191 VSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIK 250
+ IFME G+L + R ++E I+ Y+KQI + LHE+ IVHRDIK
Sbjct: 1359 ELHREEMYIFMEYCDEGTLEEVSRLG---LQEHVIRLYSKQITIAINVLHEHGIVHRDIK 1415
Query: 251 GDNVLVNTYSGVVKISDFGTSKRL---AGVNPCTETFT-GTLQYMAPEIIDQGP-RGYGA 305
G N+ + T SG++K+ DFG S +L A P T GT YMAPE+I + G+G
Sbjct: 1416 GANIFL-TSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGR 1474
Query: 306 PADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFE 365
ADIWSLGC +IEM T K P+HE M+KVGM P IPE LS E + F+ C E
Sbjct: 1475 AADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH-KPPIPERLSPEGKDFLSHCLE 1533
Query: 366 PDPHKRATTAELLREGFLR 384
DP R T ++LL F++
Sbjct: 1534 SDPKMRWTASQLLDHSFVK 1552
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 141 bits (356), Expect = 2e-33
Identities = 92/256 (35%), Positives = 136/256 (53%), Gaps = 13/256 (5%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVS 192
LG+G+YG VY +AIK++P Q + +EI++ + ++V+Y GS
Sbjct: 36 LGEGSYGSVYKAIHKETGQIVAIKQVPVESDL--QEIIKEISIMQQCDSPHVVKYYGSYF 93
Query: 193 ENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGD 252
+N + I ME GS+S ++R + + E I + L+GL+YLH + +HRDIK
Sbjct: 94 KNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAG 153
Query: 253 NVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSL 312
N+L+NT G K++DFG + +L T GT +MAPE+I + GY ADIWSL
Sbjct: 154 NILLNT-EGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE--IGYNCVADIWSL 210
Query: 313 GCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHP----EIPEALSAEARAFILSCFEPDP 368
G T IEMA KPP+ ++ P A+F M +P PE S F+ C P
Sbjct: 211 GITAIEMAEGKPPYADI-HPMRAIF---MIPTNPPPTFRKPELWSDNFTDFVKQCLVKSP 266
Query: 369 HKRATTAELLREGFLR 384
+RAT +LL+ F+R
Sbjct: 267 EQRATATQLLQHPFVR 282
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 140 bits (354), Expect = 3e-33
Identities = 103/316 (32%), Positives = 154/316 (48%), Gaps = 12/316 (3%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS-QPLHEEIALHKYLKHRNIVQYLGSV 191
+GKG++G VY G D + +AIK I ++ + + +EI + I +Y GS
Sbjct: 26 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSY 85
Query: 192 SENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKG 251
++ + I ME + GGS LL+ GP++E I ++IL+GL YLH + +HRDIK
Sbjct: 86 LKSTKLWIIMEYLGGGSALDLLKP--GPLEETYIATILREILKGLDYLHSERKIHRDIKA 143
Query: 252 DNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWS 311
NVL++ G VK++DFG + +L TF GT +MAPE+I Q Y ADIWS
Sbjct: 144 ANVLLSE-QGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS--AYDFKADIWS 200
Query: 312 LGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKR 371
LG T IE+A +PP +L P +F + P + S + F+ +C DP R
Sbjct: 201 LGITAIELAKGEPPNSDL-HPMRVLFLIPK-NSPPTLEGQHSKPFKEFVEACLNKDPRFR 258
Query: 372 ATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSD 431
T ELL+ F+ + K + +F R GE ++ S+ + D +
Sbjct: 259 PTAKELLKHKFITRYTK----KTSFLTELIDRYKRWKSEGHGEESSSEDSDIDGEAEDGE 314
Query: 432 AQPDALFERTRAPRHH 447
P F T P H
Sbjct: 315 QGPIWTFPPTIRPSPH 330
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 140 bits (353), Expect = 5e-33
Identities = 114/392 (29%), Positives = 182/392 (46%), Gaps = 30/392 (7%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSV 191
++G GTYG VY GR + AIK + + E L KY HRNI Y G+
Sbjct: 30 LVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAF 89
Query: 192 SENG------YIKIFMEQVPGGSLSALLRS-KWGPMKEPTIKFYTKQILEGLKYLHENQI 244
+ + + ME GS++ L+++ K +KE I + ++IL GL +LH++++
Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149
Query: 245 VHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEII--DQGPRG 302
+HRDIKG NVL+ T + VK+ DFG S +L TF GT +MAPE+I D+ P
Sbjct: 150 IHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 -YGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFIL 361
Y +D+WSLG T IEMA PP ++ P A+F + + S + ++FI
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDM-HPMRALFLIPRNPAPRLKSKKWSKKFQSFIE 267
Query: 362 SCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSS 421
SC + +R T +L++ F+R ++ RI K + +GE T
Sbjct: 268 SCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDH-----IDRTKKKRGEKDETEYE 322
Query: 422 EHGSVSPDSD---AQPDALFE---RTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQ 475
GS + + +P ++ + R L L+ + S AL + L + ++
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 476 GLFLLRKDSERRAILYKILWEEQNQVASNLQE 507
L + ++R EEQ + L+E
Sbjct: 383 HKRQLLAERQKRI-------EEQKEQRRRLEE 407
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 140 bits (353), Expect = 5e-33
Identities = 114/392 (29%), Positives = 182/392 (46%), Gaps = 30/392 (7%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSV 191
++G GTYG VY GR + AIK + + E L KY HRNI Y G+
Sbjct: 30 LVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAF 89
Query: 192 SENG------YIKIFMEQVPGGSLSALLRS-KWGPMKEPTIKFYTKQILEGLKYLHENQI 244
+ + + ME GS++ L+++ K +KE I + ++IL GL +LH++++
Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149
Query: 245 VHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEII--DQGPRG 302
+HRDIKG NVL+ T + VK+ DFG S +L TF GT +MAPE+I D+ P
Sbjct: 150 IHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 -YGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFIL 361
Y +D+WSLG T IEMA PP ++ P A+F + + S + ++FI
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDM-HPMRALFLIPRNPAPRLKSKKWSKKFQSFIE 267
Query: 362 SCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSS 421
SC + +R T +L++ F+R ++ RI K + +GE T
Sbjct: 268 SCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDH-----IDRTKKKRGEKDETEYE 322
Query: 422 EHGSVSPDSD---AQPDALFE---RTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQ 475
GS + + +P ++ + R L L+ + S AL + L + ++
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 476 GLFLLRKDSERRAILYKILWEEQNQVASNLQE 507
L + ++R EEQ + L+E
Sbjct: 383 HKRQLLAERQKRI-------EEQKEQRRRLEE 407
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 140 bits (353), Expect = 5e-33
Identities = 114/392 (29%), Positives = 182/392 (46%), Gaps = 30/392 (7%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSV 191
++G GTYG VY GR + AIK + + E L KY HRNI Y G+
Sbjct: 30 LVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAF 89
Query: 192 SENG------YIKIFMEQVPGGSLSALLRS-KWGPMKEPTIKFYTKQILEGLKYLHENQI 244
+ + + ME GS++ L+++ K +KE I + ++IL GL +LH++++
Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149
Query: 245 VHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEII--DQGPRG 302
+HRDIKG NVL+ T + VK+ DFG S +L TF GT +MAPE+I D+ P
Sbjct: 150 IHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 -YGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFIL 361
Y +D+WSLG T IEMA PP ++ P A+F + + S + ++FI
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDM-HPMRALFLIPRNPAPRLKSKKWSKKFQSFIE 267
Query: 362 SCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSS 421
SC + +R T +L++ F+R ++ RI K + +GE T
Sbjct: 268 SCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDH-----IDRTKKKRGEKDETEYE 322
Query: 422 EHGSVSPDSD---AQPDALFE---RTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQ 475
GS + + +P ++ + R L L+ + S AL + L + ++
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 476 GLFLLRKDSERRAILYKILWEEQNQVASNLQE 507
L + ++R EEQ + L+E
Sbjct: 383 HKRQLLAERQKRI-------EEQKEQRRRLEE 407
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 140 bits (353), Expect = 5e-33
Identities = 114/392 (29%), Positives = 182/392 (46%), Gaps = 30/392 (7%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSV 191
++G GTYG VY GR + AIK + + E L KY HRNI Y G+
Sbjct: 30 LVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAF 89
Query: 192 SENG------YIKIFMEQVPGGSLSALLRS-KWGPMKEPTIKFYTKQILEGLKYLHENQI 244
+ + + ME GS++ L+++ K +KE I + ++IL GL +LH++++
Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149
Query: 245 VHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEII--DQGPRG 302
+HRDIKG NVL+ T + VK+ DFG S +L TF GT +MAPE+I D+ P
Sbjct: 150 IHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 -YGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFIL 361
Y +D+WSLG T IEMA PP ++ P A+F + + S + ++FI
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDM-HPMRALFLIPRNPAPRLKSKKWSKKFQSFIE 267
Query: 362 SCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSS 421
SC + +R T +L++ F+R ++ RI K + +GE T
Sbjct: 268 SCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDH-----IDRTKKKRGEKDETEYE 322
Query: 422 EHGSVSPDSD---AQPDALFE---RTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQ 475
GS + + +P ++ + R L L+ + S AL + L + ++
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 476 GLFLLRKDSERRAILYKILWEEQNQVASNLQE 507
L + ++R EEQ + L+E
Sbjct: 383 HKRQLLAERQKRI-------EEQKEQRRRLEE 407
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 140 bits (353), Expect = 5e-33
Identities = 114/392 (29%), Positives = 182/392 (46%), Gaps = 30/392 (7%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSV 191
++G GTYG VY GR + AIK + + E L KY HRNI Y G+
Sbjct: 30 LVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAF 89
Query: 192 SENG------YIKIFMEQVPGGSLSALLRS-KWGPMKEPTIKFYTKQILEGLKYLHENQI 244
+ + + ME GS++ L+++ K +KE I + ++IL GL +LH++++
Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149
Query: 245 VHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEII--DQGPRG 302
+HRDIKG NVL+ T + VK+ DFG S +L TF GT +MAPE+I D+ P
Sbjct: 150 IHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 -YGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFIL 361
Y +D+WSLG T IEMA PP ++ P A+F + + S + ++FI
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDM-HPMRALFLIPRNPAPRLKSKKWSKKFQSFIE 267
Query: 362 SCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSS 421
SC + +R T +L++ F+R ++ RI K + +GE T
Sbjct: 268 SCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDH-----IDRTKKKRGEKDETEYE 322
Query: 422 EHGSVSPDSD---AQPDALFE---RTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQ 475
GS + + +P ++ + R L L+ + S AL + L + ++
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 476 GLFLLRKDSERRAILYKILWEEQNQVASNLQE 507
L + ++R EEQ + L+E
Sbjct: 383 HKRQLLAERQKRI-------EEQKEQRRRLEE 407
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 140 bits (353), Expect = 5e-33
Identities = 114/392 (29%), Positives = 182/392 (46%), Gaps = 30/392 (7%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSV 191
++G GTYG VY GR + AIK + + E L KY HRNI Y G+
Sbjct: 30 LVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAF 89
Query: 192 SENG------YIKIFMEQVPGGSLSALLRS-KWGPMKEPTIKFYTKQILEGLKYLHENQI 244
+ + + ME GS++ L+++ K +KE I + ++IL GL +LH++++
Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149
Query: 245 VHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEII--DQGPRG 302
+HRDIKG NVL+ T + VK+ DFG S +L TF GT +MAPE+I D+ P
Sbjct: 150 IHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 -YGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFIL 361
Y +D+WSLG T IEMA PP ++ P A+F + + S + ++FI
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDM-HPMRALFLIPRNPAPRLKSKKWSKKFQSFIE 267
Query: 362 SCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSS 421
SC + +R T +L++ F+R ++ RI K + +GE T
Sbjct: 268 SCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDH-----IDRTKKKRGEKDETEYE 322
Query: 422 EHGSVSPDSD---AQPDALFE---RTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQ 475
GS + + +P ++ + R L L+ + S AL + L + ++
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 476 GLFLLRKDSERRAILYKILWEEQNQVASNLQE 507
L + ++R EEQ + L+E
Sbjct: 383 HKRQLLAERQKRI-------EEQKEQRRRLEE 407
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 140 bits (353), Expect = 5e-33
Identities = 114/392 (29%), Positives = 182/392 (46%), Gaps = 30/392 (7%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSV 191
++G GTYG VY GR + AIK + + E L KY HRNI Y G+
Sbjct: 30 LVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAF 89
Query: 192 SENG------YIKIFMEQVPGGSLSALLRS-KWGPMKEPTIKFYTKQILEGLKYLHENQI 244
+ + + ME GS++ L+++ K +KE I + ++IL GL +LH++++
Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149
Query: 245 VHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEII--DQGPRG 302
+HRDIKG NVL+ T + VK+ DFG S +L TF GT +MAPE+I D+ P
Sbjct: 150 IHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 -YGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFIL 361
Y +D+WSLG T IEMA PP ++ P A+F + + S + ++FI
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDM-HPMRALFLIPRNPAPRLKSKKWSKKFQSFIE 267
Query: 362 SCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSS 421
SC + +R T +L++ F+R ++ RI K + +GE T
Sbjct: 268 SCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDH-----IDRTKKKRGEKDETEYE 322
Query: 422 EHGSVSPDSD---AQPDALFE---RTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQ 475
GS + + +P ++ + R L L+ + S AL + L + ++
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 476 GLFLLRKDSERRAILYKILWEEQNQVASNLQE 507
L + ++R EEQ + L+E
Sbjct: 383 HKRQLLAERQKRI-------EEQKEQRRRLEE 407
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 140 bits (353), Expect = 5e-33
Identities = 114/392 (29%), Positives = 182/392 (46%), Gaps = 30/392 (7%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSV 191
++G GTYG VY GR + AIK + + E L KY HRNI Y G+
Sbjct: 30 LVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAF 89
Query: 192 SENG------YIKIFMEQVPGGSLSALLRS-KWGPMKEPTIKFYTKQILEGLKYLHENQI 244
+ + + ME GS++ L+++ K +KE I + ++IL GL +LH++++
Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149
Query: 245 VHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEII--DQGPRG 302
+HRDIKG NVL+ T + VK+ DFG S +L TF GT +MAPE+I D+ P
Sbjct: 150 IHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDA 208
Query: 303 -YGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFIL 361
Y +D+WSLG T IEMA PP ++ P A+F + + S + ++FI
Sbjct: 209 TYDFKSDLWSLGITAIEMAEGAPPLCDM-HPMRALFLIPRNPAPRLKSKKWSKKFQSFIE 267
Query: 362 SCFEPDPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSS 421
SC + +R T +L++ F+R ++ RI K + +GE T
Sbjct: 268 SCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDH-----IDRTKKKRGEKDETEYE 322
Query: 422 EHGSVSPDSD---AQPDALFE---RTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQ 475
GS + + +P ++ + R L L+ + S AL + L + ++
Sbjct: 323 YSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEE 382
Query: 476 GLFLLRKDSERRAILYKILWEEQNQVASNLQE 507
L + ++R EEQ + L+E
Sbjct: 383 HKRQLLAERQKRI-------EEQKEQRRRLEE 407
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 140 bits (353), Expect = 5e-33
Identities = 107/361 (29%), Positives = 163/361 (45%), Gaps = 41/361 (11%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVS 192
LG G +G VY ++ V A K I + + EI + H NIV+ L +
Sbjct: 40 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFY 99
Query: 193 ENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGD 252
+ I +E GG++ A++ P+ E I+ KQ L+ L YLH+N+I+HRD+K
Sbjct: 100 YENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAG 159
Query: 253 NVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEII---DQGPRGYGAPADI 309
N+L T G +K++DFG S + ++F GT +MAPE++ R Y AD+
Sbjct: 160 NILF-TLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADV 218
Query: 310 WSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEI---PEALSAEARAFILSCFEP 366
WSLG T+IEMA +PP HEL P + K+ K P P S+ + F+ C E
Sbjct: 219 WSLGITLIEMAEIEPPHHEL-NPMRVLLKIA--KSEPPTLAQPSRWSSNFKDFLKKCLEK 275
Query: 367 DPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSV 426
+ R TT++LL+ F+ V+ K R L + + T E G
Sbjct: 276 NVDARWTTSQLLQHPFV-TVDSNKPIR--------------ELIAEAKAEVTEEVEDGKE 320
Query: 427 SPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDR-DQGLFLLRKDSE 485
+ + ++ L +P A D +ASS ED+ Q +L SE
Sbjct: 321 EDEEEETENS---------------LPIPASKRASSDLSIASSEEDKLSQNACILESVSE 365
Query: 486 R 486
+
Sbjct: 366 K 366
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 140 bits (352), Expect = 6e-33
Identities = 91/256 (35%), Positives = 138/256 (53%), Gaps = 13/256 (5%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVS 192
LG+G+YG V+ + +AIK++P Q + +EI++ + +V+Y GS
Sbjct: 33 LGEGSYGSVFKAIHKESGQVVAIKQVPVESDL--QEIIKEISIMQQCDSPYVVKYYGSYF 90
Query: 193 ENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGD 252
+N + I ME GS+S ++R + + E I K L+GL+YLH + +HRDIK
Sbjct: 91 KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAG 150
Query: 253 NVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSL 312
N+L+NT G K++DFG + +L T GT +MAPE+I + GY ADIWSL
Sbjct: 151 NILLNT-EGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQE--IGYNCVADIWSL 207
Query: 313 GCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHP----EIPEALSAEARAFILSCFEPDP 368
G T IEMA KPP+ ++ P A+F M +P PE S + F+ C +P
Sbjct: 208 GITSIEMAEGKPPYADI-HPMRAIF---MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNP 263
Query: 369 HKRATTAELLREGFLR 384
+RAT +LL+ F++
Sbjct: 264 EQRATATQLLQHPFIK 279
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 140 bits (352), Expect = 6e-33
Identities = 101/304 (33%), Positives = 150/304 (49%), Gaps = 21/304 (6%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS-QPLHEEIALHKYLKHRNIVQYLGSV 191
+GKG++G V+ G D Q +AIK I ++ + + +EI + + +Y GS
Sbjct: 30 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 89
Query: 192 SENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKG 251
++ + I ME + GGS LL GP+ E I ++IL+GL YLH + +HRDIK
Sbjct: 90 LKDTKLWIIMEYLGGGSALDLLEP--GPLDETQIATILREILKGLDYLHSEKKIHRDIKA 147
Query: 252 DNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWS 311
NVL++ + G VK++DFG + +L TF GT +MAPE+I Q Y + ADIWS
Sbjct: 148 ANVLLSEH-GEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS--AYDSKADIWS 204
Query: 312 LGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKR 371
LG T IE+A +PP EL P +F + P + S + F+ +C +P R
Sbjct: 205 LGITAIELARGEPPHSEL-HPMKVLFLIPK-NNPPTLEGNYSKPLKEFVEACLNKEPSFR 262
Query: 372 ATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSD 431
T ELL+ F+ + KK + L + + S S S DSD
Sbjct: 263 PTAKELLKHKFI--LRNAKKT-----------SYLTELIDRYKRWKAEQSHDDSSSEDSD 309
Query: 432 AQPD 435
A+ D
Sbjct: 310 AETD 313
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 140 bits (352), Expect = 6e-33
Identities = 101/304 (33%), Positives = 150/304 (49%), Gaps = 21/304 (6%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS-QPLHEEIALHKYLKHRNIVQYLGSV 191
+GKG++G V+ G D Q +AIK I ++ + + +EI + + +Y GS
Sbjct: 42 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSY 101
Query: 192 SENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKG 251
++ + I ME + GGS LL GP+ E I ++IL+GL YLH + +HRDIK
Sbjct: 102 LKDTKLWIIMEYLGGGSALDLLEP--GPLDETQIATILREILKGLDYLHSEKKIHRDIKA 159
Query: 252 DNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWS 311
NVL++ + G VK++DFG + +L TF GT +MAPE+I Q Y + ADIWS
Sbjct: 160 ANVLLSEH-GEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQS--AYDSKADIWS 216
Query: 312 LGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKR 371
LG T IE+A +PP EL P +F + P + S + F+ +C +P R
Sbjct: 217 LGITAIELARGEPPHSEL-HPMKVLFLIPK-NNPPTLEGNYSKPLKEFVEACLNKEPSFR 274
Query: 372 ATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSD 431
T ELL+ F+ + KK + L + + S S S DSD
Sbjct: 275 PTAKELLKHKFI--LRNAKKT-----------SYLTELIDRYKRWKAEQSHDDSSSEDSD 321
Query: 432 AQPD 435
A+ D
Sbjct: 322 AETD 325
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 139 bits (351), Expect = 8e-33
Identities = 90/255 (35%), Positives = 137/255 (53%), Gaps = 11/255 (4%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVS 192
+G+G G VY D++ +AIK++ + + + EI + + K+ NIV YL S
Sbjct: 276 IGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 335
Query: 193 ENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGD 252
+ + ME + GGSL+ ++ M E I ++ L+ L++LH NQ++HRDIK D
Sbjct: 336 VGDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSD 393
Query: 253 NVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSL 312
N+L+ G VK++DFG ++ T GT +MAPE++ + + YG DIWSL
Sbjct: 394 NILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIWSL 450
Query: 313 GCTIIEMATSKPPFHELGE-PQAAMFKVGMFKIHPEI--PEALSAEARAFILSCFEPDPH 369
G IEM +PP+ L E P A++ + PE+ PE LSA R F+ C E D
Sbjct: 451 GIMAIEMIEGEPPY--LNENPLRALYLIAT-NGTPELQNPEKLSAIFRDFLNRCLEMDVE 507
Query: 370 KRATTAELLREGFLR 384
KR + ELL+ FL+
Sbjct: 508 KRGSAKELLQHQFLK 522
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 139 bits (349), Expect = 1e-32
Identities = 91/255 (35%), Positives = 137/255 (53%), Gaps = 11/255 (4%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVS 192
+G+G G V+ D++ +AIK+I + + + EI + K LK+ NIV +L S
Sbjct: 255 IGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYL 314
Query: 193 ENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGD 252
+ + ME + GGSL+ ++ M E I ++ L+ L++LH NQ++HRDIK D
Sbjct: 315 VGDELFVVMEYLAGGSLTDVVTETC--MDEAQIAAVCRECLQALEFLHANQVIHRDIKSD 372
Query: 253 NVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSL 312
NVL+ G VK++DFG ++ T GT +MAPE++ + + YG DIWSL
Sbjct: 373 NVLLG-MEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIWSL 429
Query: 313 GCTIIEMATSKPPFHELGE-PQAAMFKVGMFKIHPEI--PEALSAEARAFILSCFEPDPH 369
G IEM +PP+ L E P A++ + PE+ PE LS R F+ C E D
Sbjct: 430 GIMAIEMVEGEPPY--LNENPLRALYLIAT-NGTPELQNPEKLSPIFRDFLNRCLEMDVE 486
Query: 370 KRATTAELLREGFLR 384
KR + ELL+ FL+
Sbjct: 487 KRGSAKELLQHPFLK 501
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 139 bits (349), Expect = 1e-32
Identities = 92/257 (35%), Positives = 136/257 (52%), Gaps = 8/257 (3%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS-QPLHEEIALHKYLKHRNIVQYLGSV 191
+GKG++G V+ G D Q +AIK I ++ + + +EI + + +Y GS
Sbjct: 30 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSY 89
Query: 192 SENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKG 251
+ + I ME + GGS LLR+ GP E I K+IL+GL YLH + +HRDIK
Sbjct: 90 LKGSKLWIIMEYLGGGSALDLLRA--GPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKA 147
Query: 252 DNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWS 311
NVL++ G VK++DFG + +L TF GT +MAPE+I Q Y + ADIWS
Sbjct: 148 ANVLLSE-QGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQS--AYDSKADIWS 204
Query: 312 LGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKR 371
LG T IE+A +PP ++ P +F + P + + + FI +C DP R
Sbjct: 205 LGITAIELAKGEPPNSDM-HPMRVLFLIPK-NNPPTLVGDFTKSFKEFIDACLNKDPSFR 262
Query: 372 ATTAELLREGFLRQVNK 388
T ELL+ F+ + +K
Sbjct: 263 PTAKELLKHKFIVKNSK 279
>gi|93004081 polo-like kinase 2 [Homo sapiens]
Length = 685
Score = 138 bits (348), Expect = 2e-32
Identities = 83/259 (32%), Positives = 140/259 (54%), Gaps = 14/259 (5%)
Query: 132 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQP-----LHEEIALHKYLKHRNIVQ 186
VLGKG + Y DL+N A K IP SR ++P + +EI LH+ L H+++VQ
Sbjct: 87 VLGKGGFAKCYEMTDLTNNKVYAAKIIPH--SRVAKPHQREKIDKEIELHRILHHKHVVQ 144
Query: 187 YLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVH 246
+ + I I +E S++ +L+++ + EP +++Y +QI+ GLKYLHE +I+H
Sbjct: 145 FYHYFEDKENIYILLEYCSRRSMAHILKAR-KVLTEPEVRYYLRQIVSGLKYLHEQEILH 203
Query: 247 RDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAP 306
RD+K N +N + +K+ DFG + RL + T GT Y++PE++++ +G+G
Sbjct: 204 RDLKLGNFFINE-AMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNK--QGHGCE 260
Query: 307 ADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEP 366
+DIW+LGC + M +PPF + + + +P +L A A+ I S
Sbjct: 261 SDIWALGCVMYTMLLGRPPFETTNLKETYRC---IREARYTMPSSLLAPAKHLIASMLSK 317
Query: 367 DPHKRATTAELLREGFLRQ 385
+P R + +++R F Q
Sbjct: 318 NPEDRPSLDDIIRHDFFLQ 336
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 138 bits (347), Expect = 2e-32
Identities = 89/255 (34%), Positives = 136/255 (53%), Gaps = 11/255 (4%)
Query: 133 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVS 192
+G+G G VY D++ +AIK++ + + + EI + + K+ NIV YL S
Sbjct: 289 IGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL 348
Query: 193 ENGYIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGD 252
+ + ME + GGSL+ ++ M E I ++ L+ L +LH NQ++HRDIK D
Sbjct: 349 VGDELWVVMEYLAGGSLTDVVTETC--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSD 406
Query: 253 NVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSL 312
N+L+ G VK++DFG ++ T GT +MAPE++ + + YG DIWSL
Sbjct: 407 NILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIWSL 463
Query: 313 GCTIIEMATSKPPFHELGE-PQAAMFKVGMFKIHPEI--PEALSAEARAFILSCFEPDPH 369
G IEM +PP+ L E P A++ + PE+ PE LSA R F+ C E D
Sbjct: 464 GIMAIEMVEGEPPY--LNENPLRALYLIAT-NGTPELQNPERLSAVFRDFLNRCLEMDVD 520
Query: 370 KRATTAELLREGFLR 384
+R + ELL+ FL+
Sbjct: 521 RRGSAKELLQHPFLK 535
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,349,210
Number of Sequences: 37866
Number of extensions: 1480072
Number of successful extensions: 7468
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 691
Number of HSP's successfully gapped in prelim test: 200
Number of HSP's that attempted gapping in prelim test: 4798
Number of HSP's gapped (non-prelim): 1224
length of query: 788
length of database: 18,247,518
effective HSP length: 110
effective length of query: 678
effective length of database: 14,082,258
effective search space: 9547770924
effective search space used: 9547770924
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.