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Search of human proteins with 12007648
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
(487 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 983 0.0
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 838 0.0
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 343 2e-94
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 337 1e-92
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 333 2e-91
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 332 4e-91
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 332 6e-91
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 326 3e-89
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 318 9e-87
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 315 8e-86
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 305 8e-83
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 286 4e-77
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 279 5e-75
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 276 2e-74
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 223 2e-58
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 184 2e-46
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 171 1e-42
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 152 7e-37
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 152 7e-37
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 152 7e-37
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 142 9e-34
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 142 9e-34
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 136 4e-32
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 136 4e-32
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 135 6e-32
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 135 6e-32
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 135 6e-32
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 135 1e-31
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 127 2e-29
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 127 2e-29
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 983 bits (2540), Expect = 0.0
Identities = 487/487 (100%), Positives = 487/487 (100%)
Query: 1 MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS 60
MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS
Sbjct: 1 MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS 60
Query: 61 WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS 120
WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS
Sbjct: 61 WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS 120
Query: 121 SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS 180
SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS
Sbjct: 121 SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS 180
Query: 181 ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT 240
ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT
Sbjct: 181 ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT 240
Query: 241 QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIY 300
QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIY
Sbjct: 241 QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIY 300
Query: 301 SEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK 360
SEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK
Sbjct: 301 SEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK 360
Query: 361 LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA 420
LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA
Sbjct: 361 LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA 420
Query: 421 ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI 480
ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI
Sbjct: 421 ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI 480
Query: 481 KTITVKH 487
KTITVKH
Sbjct: 481 KTITVKH 487
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 838 bits (2166), Expect = 0.0
Identities = 428/487 (87%), Positives = 430/487 (88%), Gaps = 54/487 (11%)
Query: 1 MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS 60
MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS
Sbjct: 1 MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS 60
Query: 61 WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS 120
WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS
Sbjct: 61 WSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASS 120
Query: 121 SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS 180
SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS
Sbjct: 121 SLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPS 180
Query: 181 ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT 240
ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT
Sbjct: 181 ELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIT 240
Query: 241 QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIY 300
QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQ
Sbjct: 241 QLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQ----------------V 284
Query: 301 SEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK 360
++KR ALAEGAQIWCGEGVDK
Sbjct: 285 RSYVKR--------------------------------------ALAEGAQIWCGEGVDK 306
Query: 361 LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA 420
LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA
Sbjct: 307 LSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA 366
Query: 421 ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI 480
ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI
Sbjct: 367 ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI 426
Query: 481 KTITVKH 487
KTITVKH
Sbjct: 427 KTITVKH 433
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 343 bits (881), Expect = 2e-94
Identities = 179/460 (38%), Positives = 284/460 (61%), Gaps = 4/460 (0%)
Query: 27 SYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEE 86
+++P+TG V SG+ E+ AV+ A+ AF WS +S ER R+L + A ++ + +E
Sbjct: 55 AFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDE 114
Query: 87 FAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVG 146
A E + GK++ AR +DI S Q ++A + E Q+ G YT R P+G
Sbjct: 115 IATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPG-GSFGYTRREPLG 172
Query: 147 VAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNI 206
V I WN P + +WK APA+A GN ++ KPS T V+A +L ++ +AGVPPG+ N+
Sbjct: 173 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNV 232
Query: 207 VFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDA 266
V G G G+ L HP+V +SFTGS PT +I ++SA K ++LELGGK+P IIF D
Sbjct: 233 VQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDC 291
Query: 267 NLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSI 326
+++ + + ++F QG++C +R+FVQK I +F + V+ T++ K+G P +
Sbjct: 292 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 351
Query: 327 GALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESC 386
G LI++ HLE+V +VK A +GA++ CG + P + + GY+M P V+T+ +D+
Sbjct: 352 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP-KLKDGYYMRPCVLTNCRDDMT 410
Query: 387 CMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTN 446
C+ EEIFGPV ++ FD+E EV+ERAN+ +GLAA V++ ++ R HRV +LQ+G + N
Sbjct: 411 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 470
Query: 447 CWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
+ + + LPFGG K SG GRE + + ++++++KT+ V+
Sbjct: 471 NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 510
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 337 bits (864), Expect = 1e-92
Identities = 183/463 (39%), Positives = 275/463 (59%), Gaps = 12/463 (2%)
Query: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFP---SWSSRSPQERSRVLNQVADLLEQSL 84
++P+T E C+V K++++ AVKAAR+AF W + ER R+L ++ADL+E+
Sbjct: 41 FNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDR 100
Query: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAP 144
A ES + GK + A D+ ++ R+ A + +D YT P
Sbjct: 101 LLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDG-NFFTYTRHEP 159
Query: 145 VGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVV 204
+GV G I PWN PL +L WKI PA++ GNTV+ KP+E T +TA + L+ +AG PPGVV
Sbjct: 160 IGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVV 219
Query: 205 NIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAIIF 263
NIV G GP G A+ SH ++ ++FTGS + I + + + K+++LELGGK+P I+
Sbjct: 220 NIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVL 279
Query: 264 EDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPL 323
DA+LD + F +QG+ C+ SRIFV++SIY EF++R VE +K+ +G P P
Sbjct: 280 ADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPG 339
Query: 324 VSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKD 383
V+ G I K +K+ ++ EGA++ CG G P N+ GYF+ PTV +++ D
Sbjct: 340 VTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG------PWGNK-GYFVQPTVFSNVTD 392
Query: 384 ESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLV 443
E EEIFGPV ++ F S ++VI+RANN YGL+A V++ ++ + ++ LQ+G V
Sbjct: 393 EMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTV 452
Query: 444 WTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
W NC+ + PFGG K SG GRE + + +TE+KT+TVK
Sbjct: 453 WVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 333 bits (854), Expect = 2e-91
Identities = 182/462 (39%), Positives = 266/462 (57%), Gaps = 12/462 (2%)
Query: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSLE 85
+PST E C V K +++ AV+AA+ AF W R R+L+Q+ADL+E+
Sbjct: 53 NPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRA 112
Query: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
A E+ D GK A +D+ ++ R+FA + + D + +T P+
Sbjct: 113 TLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDD-NVVCFTRHEPI 171
Query: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
GV G I+PWN PL +L WK+APA+ GNT++ KP+E T +TA L L+ +AG PPGVVN
Sbjct: 172 GVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVN 231
Query: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQ-LSAPHCKKLSLELGGKNPAIIFE 264
IV G GP VG A+ SHP++ I+FTGS + + + S + K+++LELGGKNP I+
Sbjct: 232 IVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCA 291
Query: 265 DANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLV 324
DA+LD + + F NQG+ C SR+FV++ +YSEF++R VE +K VG P D
Sbjct: 292 DADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKT 351
Query: 325 SIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDE 384
G I + +K+ ++ EGA++ CG A G F+ PTV +++ D
Sbjct: 352 EQGPQIDQKQFDKILELIESGKKEGAKLECGGS-------AMEDKGLFIKPTVFSEVTDN 404
Query: 385 SCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVW 444
EEIFGPV ++ F S EEVI+RAN+ YGL A V++ N+ + ++A L+SG VW
Sbjct: 405 MRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVW 464
Query: 445 TNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
NC+ PFGG K SG GRE + + +TE+KT+T+K
Sbjct: 465 INCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 332 bits (852), Expect = 4e-91
Identities = 182/463 (39%), Positives = 267/463 (57%), Gaps = 14/463 (3%)
Query: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAFP---SWSSRSPQERSRVLNQVADLLEQSLE 85
+PSTGEV C+V K++++ AVKAAR AF W R R+LN++ADL+E+
Sbjct: 58 NPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRT 117
Query: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
A E+ D GK ++ +D+ ++ R++A + + + +D YT PV
Sbjct: 118 YLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDG-DFFSYTRHEPV 176
Query: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
GV G I PWN PL + WK+ PA+A GN V+ K +E T +TA + L+ +AG PPGVVN
Sbjct: 177 GVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVN 236
Query: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA--PHCKKLSLELGGKNPAIIF 263
IV G GP G A+ SH +V ++FTGS R+ Q++A + K+++LELGGK+P II
Sbjct: 237 IVPGFGPTAGAAIASHEDVDKVAFTGSTEIG-RVIQVAAGSSNLKRVTLELGGKSPNIIM 295
Query: 264 EDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPL 323
DA++D + + F NQG+ C SR FVQ+ IY EF++R V + VG P D
Sbjct: 296 SDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSK 355
Query: 324 VSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKD 383
G + + +K+ Y+ EGA++ CG G+ GYF+ PTV D++D
Sbjct: 356 TEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAA-------DRGYFIQPTVFGDVQD 408
Query: 384 ESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLV 443
EEIFGPV ++ F + EEV+ RANN YGLAA V++ ++ + + +++ LQ+G V
Sbjct: 409 GMTIAKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTV 468
Query: 444 WTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
W NC+ + PFGG K SG GRE + +TE+KT+TVK
Sbjct: 469 WVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVK 511
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 332 bits (850), Expect = 6e-91
Identities = 182/465 (39%), Positives = 272/465 (58%), Gaps = 16/465 (3%)
Query: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSL 84
Y+P+TGE C V + K +I+ AV+AAR AF W ER R+L+++ADL+E+
Sbjct: 58 YNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDR 117
Query: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHTSECTQMDHLGCMHYTVR 142
A ES + GK A +D+ ++ FR++A + +H + D+ +T
Sbjct: 118 AVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFT---FTRH 174
Query: 143 APVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPG 202
P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T ++A + L+ +AG PPG
Sbjct: 175 EPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPG 234
Query: 203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAI 261
V+NI+ G GP G A+ SH + I+FTGS + I + + + K+++LELGGK+P I
Sbjct: 235 VINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNI 294
Query: 262 IFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSD 321
IF DA+LD + + F NQG+ C SRIFV++SIY EF++R VE ++ VG P D
Sbjct: 295 IFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFD 354
Query: 322 PLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDI 381
P G I K K+ ++ +AEGA++ CG + G+F+ PTV +++
Sbjct: 355 PTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------KGLGRKGFFIEPTVFSNV 407
Query: 382 KDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSG 441
D+ EEIFGPV ++ F + +EVIERANN +GL A V+++++ + V+ +Q+G
Sbjct: 408 TDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAG 467
Query: 442 LVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
VW NC+ PFGG K SG GRE + ++E+KT+TVK
Sbjct: 468 TVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 512
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 326 bits (836), Expect = 3e-89
Identities = 179/462 (38%), Positives = 266/462 (57%), Gaps = 12/462 (2%)
Query: 29 DPSTGEVYCRVPNSGKDEIEAAVKAAREAF---PSWSSRSPQERSRVLNQVADLLEQSLE 85
+P+TGEV V + +++ AVKAAREAF W ER R+LN++ADL+E+
Sbjct: 58 NPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRV 117
Query: 86 EFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPV 145
A E+ D GK + +D+ ++ +R+FA + + MD +T PV
Sbjct: 118 YLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFC-FTRHEPV 176
Query: 146 GVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVN 205
GV G I PWN PL + WK+APA+A GNTV+ K +E T ++A L L+ +AG PPGVVN
Sbjct: 177 GVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVN 236
Query: 206 IVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAP-HCKKLSLELGGKNPAIIFE 264
I+ G GP G A+ H +V ++FTGS I + + + K+++LELGGK+P+I+
Sbjct: 237 IITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLA 296
Query: 265 DANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLV 324
DA+++ + + F N G+ C SR FV++SIY+EFL+R VE ++ KVG P +
Sbjct: 297 DADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDT 356
Query: 325 SIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDE 384
G + K E+V Y++ EGA++ CG + G+F+ PTV ++D+
Sbjct: 357 QQGPQVDKEQFERVLGYIQLGQKEGAKLLCGG-------ERFGERGFFIKPTVFGGVQDD 409
Query: 385 SCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVW 444
EEIFGPV + F EEV+ERANN +YGLAA V++ ++ + + LQ+G VW
Sbjct: 410 MRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVW 469
Query: 445 TNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
N + I + PFGG K SG GRE +D +TE+KT+T+K
Sbjct: 470 VNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIK 511
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 318 bits (814), Expect = 9e-87
Identities = 178/486 (36%), Positives = 285/486 (58%), Gaps = 19/486 (3%)
Query: 13 FIDGKFLPCSS--YIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS--WSSRSPQE 68
FI+G+F D+ +P+ G C+V + +++ AV AA++AF + W + +E
Sbjct: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
Query: 69 RSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFAS---SSLHHT 125
R R++ ++ADLLE++ EE A E+ D G LA I SVQ FR+FA T
Sbjct: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
Query: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Q + +T + P+GV +I PWN PL +L WK A +AAGNT++ KP+++T +
Sbjct: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPL 625
Query: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
TA +L KAG P GV+NI+ G+G G+ L HP++ + FTGS P ++I + A
Sbjct: 626 TALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAV 685
Query: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFL 304
+ KK+SLELGGK+P IIF D LD+ + + + F N+GE C+ R+FV++SI+ EF+
Sbjct: 686 SNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFV 745
Query: 305 KRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQ-IWCGEGVDKLSL 363
R VE +K K+G P D G KAHLEK+ Y + + EGA ++ G V +
Sbjct: 746 TRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQR--- 802
Query: 364 PARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSE--EEVIERANNVKYGLAA 421
G+FM PTV TD++D EE FGP+ + F + + V++RAN+ +YGLA+
Sbjct: 803 -----PGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLAS 857
Query: 422 TVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIK 481
V++ ++ + V++KL++G V+ N + ++ PFGG+K SG G++ +++ + + + K
Sbjct: 858 GVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTK 917
Query: 482 TITVKH 487
T+T+++
Sbjct: 918 TVTLEY 923
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 315 bits (806), Expect = 8e-86
Identities = 183/485 (37%), Positives = 281/485 (57%), Gaps = 17/485 (3%)
Query: 13 FIDGKFLPC--SSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS--WSSRSPQE 68
FI G+F+ + ++ +P+ G V C+V + +++ AV AA++AF + W S ++
Sbjct: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
Query: 69 RSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFAS---SSLHHT 125
R R++ ++ADL+EQ EE A E+ D G LA + S+Q FR+FA T
Sbjct: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
Query: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Q + T + PVGV G+I PWN PL +L+WK A +AAGNTV+ KP+++T +
Sbjct: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPL 604
Query: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
TA +L KAG+P GVVN++ G+G VG+ L HP+V I FTGS + I + A
Sbjct: 605 TALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAI 664
Query: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFL 304
+ KK+SLELGGK+P IIF D +L++ + + S F N+GE C+ R+FV+ SI+ EF+
Sbjct: 665 SNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFV 724
Query: 305 KRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLP 364
+R VE RK KVG P D G AHL K+ Y + + EGA + CG +P
Sbjct: 725 RRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGN----QVP 780
Query: 365 ARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPF-DSE-EEVIERANNVKYGLAAT 422
+ G+F PTV TD++D EE FGPV + F D + + V+ RAN ++GLA+
Sbjct: 781 ---RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASG 837
Query: 423 VWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKT 482
V++ ++ + V+ KLQ+G V+ N + ++ PFGG K SG G++ + + + + +KT
Sbjct: 838 VFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKT 897
Query: 483 ITVKH 487
+T ++
Sbjct: 898 VTFEY 902
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 305 bits (780), Expect = 8e-83
Identities = 165/422 (39%), Positives = 249/422 (59%), Gaps = 13/422 (3%)
Query: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHT 125
ER R+L+++ADL+E+ A ES + GK A +D+ ++ FR++A + +H
Sbjct: 5 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 64
Query: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
+ D+ +T P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T +
Sbjct: 65 TIPVDGDYFT---FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPL 121
Query: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
+A + L+ +AG PPGV+NI+ G GP G A+ SH + I+FTGS + I + +
Sbjct: 122 SALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGR 181
Query: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFL 304
+ K+++LELGGK+P IIF DA+LD + + F NQG+ C SRIFV++SIY EF+
Sbjct: 182 SNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFV 241
Query: 305 KRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLP 364
+R VE ++ VG P DP G I K K+ ++ +AEGA++ CG
Sbjct: 242 RRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------K 294
Query: 365 ARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVW 424
+ G+F+ PTV +++ D+ EEIFGPV ++ F + +EVIERANN +GL A V+
Sbjct: 295 GLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVF 354
Query: 425 SSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTIT 484
++++ + V+ +Q+G VW NC+ PFGG K SG GRE + ++E+KT+T
Sbjct: 355 TNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 414
Query: 485 VK 486
VK
Sbjct: 415 VK 416
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 286 bits (731), Expect = 4e-77
Identities = 170/483 (35%), Positives = 271/483 (56%), Gaps = 14/483 (2%)
Query: 6 ALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRS 65
ALL ++F+ G++LP ++ DP++G V + G E AAV+AA EAF W S
Sbjct: 57 ALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116
Query: 66 PQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHT 125
+ERS +L + +L+ Q+ ++ A+ + + GK L A +I S +F+ +
Sbjct: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175
Query: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
+ ++ P+GVA +I+PWN P ++T K+ A+AAG TV+ KP+E T
Sbjct: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
Query: 186 TAWMLCKLLDKAGVPPGVVNIV---FGTGPRVGEALVSHPEVPLISFTGSQPTAERITQL 242
+A L +L +AG+P GV N++ VGEA+ + P V ISFTGS T + +
Sbjct: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHH 295
Query: 243 SAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSE 302
+A K++S+ELGG P I+F+ AN+D+ + + S F N G+ C+C+++ VQ+ I+
Sbjct: 296 AANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDA 355
Query: 303 FLKRFVEATRK-WKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKL 361
F+K F EA +K +VG + + G LI++ +EKV V A+++GA + G
Sbjct: 356 FVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGG----- 410
Query: 362 SLPARNQAGY-FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLA 420
R+Q G F PT++ ++ + C EE FGP+ V+ FD+EEE I AN GLA
Sbjct: 411 ---KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLA 467
Query: 421 ATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEI 480
+S + ++ RVA++L+ G+V N LI + PFGG+K SG+GREG+K D + E+
Sbjct: 468 GYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLEL 527
Query: 481 KTI 483
K +
Sbjct: 528 KYV 530
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 279 bits (713), Expect = 5e-75
Identities = 165/464 (35%), Positives = 246/464 (53%), Gaps = 52/464 (11%)
Query: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSL 84
Y+P+TGE C V + K +I+ AV+AAR AF W ER R+L+++ADL+E+
Sbjct: 58 YNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDR 117
Query: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHTSECTQMDHLGCMHYTVR 142
A ES + GK A +D+ ++ FR++A + +H + D+ +T
Sbjct: 118 AVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFT---FTRH 174
Query: 143 APVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPG 202
P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T ++A + L+ + G
Sbjct: 175 EPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG---- 230
Query: 203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAII 262
LI + +R+T LELGGK+P II
Sbjct: 231 ----------------------KLIQEAAGRSNLKRVT-----------LELGGKSPNII 257
Query: 263 FEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDP 322
F DA+LD + + F NQG+ C SRIFV++SIY EF++R VE ++ VG P DP
Sbjct: 258 FADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDP 317
Query: 323 LVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIK 382
G I K K+ ++ +AEGA++ CG + G+F+ PTV +++
Sbjct: 318 TTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------KGLGRKGFFIEPTVFSNVT 370
Query: 383 DESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGL 442
D+ EEIFGPV ++ F + +EVIERANN +GL A V+++++ + V+ +Q+G
Sbjct: 371 DDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGT 430
Query: 443 VWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
VW NC+ PFGG K SG GRE + ++E+KT+TVK
Sbjct: 431 VWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 474
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 276 bits (707), Expect = 2e-74
Identities = 170/496 (34%), Positives = 271/496 (54%), Gaps = 27/496 (5%)
Query: 6 ALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRS 65
ALL ++F+ G++LP ++ DP++G V + G E AAV+AA EAF W S
Sbjct: 57 ALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVS 116
Query: 66 PQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHT 125
+ERS +L + +L+ Q+ ++ A+ + + GK L A +I S +F+ +
Sbjct: 117 AKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHG-EILYSAFFLEWFSEEARRVY 175
Query: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
+ ++ P+GVA +I+PWN P ++T K+ A+AAG TV+ KP+E T
Sbjct: 176 GDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
Query: 186 TAWMLCK-------------LLDKAGVPPGVVNIV---FGTGPRVGEALVSHPEVPLISF 229
+A L + L +AG+P GV N++ VGEA+ + P V ISF
Sbjct: 236 SALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISF 295
Query: 230 TGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLC 289
TGS T + + +A K++S+ELGG P I+F+ AN+D+ + + S F N G+ C+C
Sbjct: 296 TGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVC 355
Query: 290 TSRIFVQKSIYSEFLKRFVEATRK-WKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAE 348
+++ VQ+ I+ F+K F EA +K +VG + + G LI++ +EKV V A+++
Sbjct: 356 SNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSK 415
Query: 349 GAQIWCGEGVDKLSLPARNQAGY-FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEE 407
GA + G R+Q G F PT++ ++ + C EE FGP+ V+ FD+EEE
Sbjct: 416 GATVVTGG--------KRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEE 467
Query: 408 VIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGR 467
I AN GLA +S + ++ RVA++L+ G+V N LI + PFGG+K SG+GR
Sbjct: 468 AIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGR 527
Query: 468 EGAKDSYDFFTEIKTI 483
EG+K D + E+K +
Sbjct: 528 EGSKYGIDEYLELKYV 543
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 223 bits (569), Expect = 2e-58
Identities = 150/478 (31%), Positives = 237/478 (49%), Gaps = 13/478 (2%)
Query: 13 FIDGKFLPCSS--YIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERS 70
FI GKF+ S +ID ++P+T EV RVP + K E++AA+ + + AFP+W+ S R
Sbjct: 43 FIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQ 102
Query: 71 RVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQ 130
+VL + L++++L+E A+ + +QGKTLA A D+ R +Q S + E
Sbjct: 103 QVLLRYQQLIKENLKEIAKLITLEQGKTLADAEG-DVFRGLQVVEHACSVTSLMMGETMP 161
Query: 131 MDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWML 190
Y+ R P+GV I+P+N P + W AM GNT + KPSE +L
Sbjct: 162 SITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLL 221
Query: 191 CKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKL 250
KLL +G P G +NI+ G V + HP++ ISF GS E I + + H K++
Sbjct: 222 AKLLQDSGAPDGTLNIIHGQHEAV-NFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRV 280
Query: 251 SLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEA 310
+G KN ++ DAN + + V ++F G+ C+ S V ++L VE
Sbjct: 281 QANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTA-VLVGEAKKWLPELVEH 339
Query: 311 TRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARN-QA 369
+ +V P +G LI+ E+V + + EGA I +D + + +
Sbjct: 340 AKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASIL----LDGRKIKVKGYEN 395
Query: 370 GYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVG 429
G F+ PT+I+++K C EEIFGPV V+ ++ +E I+ NN YG ++++N
Sbjct: 396 GNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGA 455
Query: 430 RVHRVAKKLQSGLVWTNCWLIRELNL-PFGGMKSSGIGREG--AKDSYDFFTEIKTIT 484
+ A + G V N + L + F G +SS G K F+T++KTIT
Sbjct: 456 TARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 184 bits (466), Expect = 2e-46
Identities = 131/484 (27%), Positives = 225/484 (46%), Gaps = 16/484 (3%)
Query: 11 ENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERS 70
E +G + I +Y P+ E RV + + E VK AREA+ W+ +R
Sbjct: 52 EGVYNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRG 111
Query: 71 RVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQ 130
++ Q+ D L + ++ S + GK L + ++ V + S
Sbjct: 112 EIVRQIGDALREKIQVLGSLVSLEMGKIL-VEGVGEVQEYVDICDYAVGLSRMIGGPILP 170
Query: 131 MDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAW-- 188
+ G PVG+ G+I+ +N P+ + W A AM GN + K + TS+ +
Sbjct: 171 SERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAV 230
Query: 189 --MLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPH 246
++ K+L+ +P + ++ G G +G A+ V L+SFTGS +++ +
Sbjct: 231 TKIIAKVLEDNKLPGAICSLTCG-GADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQER 289
Query: 247 CKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKR 306
+ LELGG N I FEDA+L +P+ + ++ G+ C R+F+ +SI+ E + R
Sbjct: 290 FGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNR 349
Query: 307 FVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPAR 366
+A + +VG P DP V G L +K + V+ A EG + G V
Sbjct: 350 LKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKV-------M 402
Query: 367 NQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSS 426
++ G ++ PT++T + ++ E F P+ V F +EEEV N VK GL++++++
Sbjct: 403 DRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTK 462
Query: 427 NVGRVHR--VAKKLQSGLVWTNCWLI-RELNLPFGGMKSSGIGREGAKDSYDFFTEIKTI 483
++GR+ R K G+V N E+ FGG K +G GRE D++ + T
Sbjct: 463 DLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTC 522
Query: 484 TVKH 487
T+ +
Sbjct: 523 TINY 526
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 171 bits (434), Expect = 1e-42
Identities = 127/465 (27%), Positives = 225/465 (48%), Gaps = 27/465 (5%)
Query: 10 LENFIDGKFLPCS--SYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQ 67
L ++++GK+L + + DP TGE + +++ AAV+AAR AF WS+
Sbjct: 40 LGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGV 99
Query: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSE 127
R++ L ++A+++++ ES G+ + R D+ + Q + H
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY------HAIQA 153
Query: 128 CTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTA 187
TQ + L P+GV GLI P + W+I PA+A G TV+A S
Sbjct: 154 STQEEALAGWE-----PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPP-ASPAP 207
Query: 188 WMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHC 247
+L +L + G PG++N++ G V L S P + ++F G+ + + A C
Sbjct: 208 LLLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLAGEC 266
Query: 248 KKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRF 307
+L L LG ++ ++ + A++D + V ++++++G L R+ +Q+S++ E ++R
Sbjct: 267 AELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGL---RLLIQESVWDEAMRRL 323
Query: 308 VEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARN 367
E + + G D V +GA A + V+ +V+ A ++GAQ++ V P+
Sbjct: 324 QERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDV-----PSER 377
Query: 368 QAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSN 427
F PT+++++ S C E+ PV PF + +E + AN G +A+VWS
Sbjct: 378 P---FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSER 434
Query: 428 VGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKD 472
+G+ + LQ G VW N +R+ ++P GG K SG G D
Sbjct: 435 LGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPD 479
Score = 83.6 bits (205), Expect = 4e-16
Identities = 68/238 (28%), Positives = 112/238 (47%), Gaps = 7/238 (2%)
Query: 13 FIDGKF-LPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSR 71
F+ G+F P + S+G ++ V G +I AV+AA +AFP W+ +SP R+
Sbjct: 531 FVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAA 590
Query: 72 VLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQM 131
+L +A LE+ A + + QG L A ++ S + R + + + Q+
Sbjct: 591 LLWALAAALERRKSTLA-SRLERQGAELKAAEA-EVELSARRLRAW-GARVQAQGHTLQV 647
Query: 132 DHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLC 191
L +R P+GV ++ P PL +APA+A GNTV+ PS + A +C
Sbjct: 648 AGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVC 707
Query: 192 KLLDKAGV-PPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCK 248
+ D A V P G+ N+V G + L H +V + + GS ++ + SA + K
Sbjct: 708 Q--DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLK 763
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 152 bits (384), Expect = 7e-37
Identities = 131/454 (28%), Positives = 214/454 (47%), Gaps = 38/454 (8%)
Query: 46 EIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALAR-- 103
+I AVK AR AF S +R Q R + L + L+++ +E A + D K A
Sbjct: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
Query: 104 -----TMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPL 158
+I +Q +A+ + TQ D L Y P+GV +I WN P
Sbjct: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL----YIHSEPLGVVLVIGTWNYPF 118
Query: 159 YLLTWKIAPAMAAGNTVIAKPSELT----SVTAWMLCKLLDKAGVPPGVVNIVFGTGPRV 214
L + A+AAGN+V+ KPSEL+ S+ A ++ + LDK P ++ G P
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPET 173
Query: 215 GEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPA 274
E L + I +TGS + I +A H ++LELGGK+P + ++ +LD
Sbjct: 174 TELLKERFDH--ILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231
Query: 275 TVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAH 334
F N G+ C+ I SI ++ +++ ++ +++ G + G +IS H
Sbjct: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARH 290
Query: 335 LEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394
++V L EG ++ G D A ++ PT++TD+ +S M EEIFG
Sbjct: 291 FQRVMG-----LIEGQKVAYGGTGDA--------ATRYIAPTILTDVDPQSPVMQEEIFG 337
Query: 395 PVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIREL- 453
PV +V S EE I+ N + LA ++SSN + ++ + SG V N ++
Sbjct: 338 PVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITL 397
Query: 454 -NLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
+LPFGG+ +SG+G K S++ F+ ++ V+
Sbjct: 398 HSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 152 bits (384), Expect = 7e-37
Identities = 131/454 (28%), Positives = 214/454 (47%), Gaps = 38/454 (8%)
Query: 46 EIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALAR-- 103
+I AVK AR AF S +R Q R + L + L+++ +E A + D K A
Sbjct: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
Query: 104 -----TMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPL 158
+I +Q +A+ + TQ D L Y P+GV +I WN P
Sbjct: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL----YIHSEPLGVVLVIGTWNYPF 118
Query: 159 YLLTWKIAPAMAAGNTVIAKPSELT----SVTAWMLCKLLDKAGVPPGVVNIVFGTGPRV 214
L + A+AAGN+V+ KPSEL+ S+ A ++ + LDK P ++ G P
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPET 173
Query: 215 GEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPA 274
E L + I +TGS + I +A H ++LELGGK+P + ++ +LD
Sbjct: 174 TELLKERFDH--ILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231
Query: 275 TVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAH 334
F N G+ C+ I SI ++ +++ ++ +++ G + G +IS H
Sbjct: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARH 290
Query: 335 LEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394
++V L EG ++ G D A ++ PT++TD+ +S M EEIFG
Sbjct: 291 FQRVMG-----LIEGQKVAYGGTGDA--------ATRYIAPTILTDVDPQSPVMQEEIFG 337
Query: 395 PVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIREL- 453
PV +V S EE I+ N + LA ++SSN + ++ + SG V N ++
Sbjct: 338 PVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITL 397
Query: 454 -NLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
+LPFGG+ +SG+G K S++ F+ ++ V+
Sbjct: 398 HSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 152 bits (384), Expect = 7e-37
Identities = 131/454 (28%), Positives = 214/454 (47%), Gaps = 38/454 (8%)
Query: 46 EIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALAR-- 103
+I AVK AR AF S +R Q R + L + L+++ +E A + D K A
Sbjct: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
Query: 104 -----TMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPL 158
+I +Q +A+ + TQ D L Y P+GV +I WN P
Sbjct: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL----YIHSEPLGVVLVIGTWNYPF 118
Query: 159 YLLTWKIAPAMAAGNTVIAKPSELT----SVTAWMLCKLLDKAGVPPGVVNIVFGTGPRV 214
L + A+AAGN+V+ KPSEL+ S+ A ++ + LDK P ++ G P
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPET 173
Query: 215 GEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPA 274
E L + I +TGS + I +A H ++LELGGK+P + ++ +LD
Sbjct: 174 TELLKERFDH--ILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231
Query: 275 TVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAH 334
F N G+ C+ I SI ++ +++ ++ +++ G + G +IS H
Sbjct: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARH 290
Query: 335 LEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394
++V L EG ++ G D A ++ PT++TD+ +S M EEIFG
Sbjct: 291 FQRVMG-----LIEGQKVAYGGTGDA--------ATRYIAPTILTDVDPQSPVMQEEIFG 337
Query: 395 PVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIREL- 453
PV +V S EE I+ N + LA ++SSN + ++ + SG V N ++
Sbjct: 338 PVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITL 397
Query: 454 -NLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
+LPFGG+ +SG+G K S++ F+ ++ V+
Sbjct: 398 HSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 142 bits (357), Expect = 9e-34
Identities = 123/450 (27%), Positives = 210/450 (46%), Gaps = 32/450 (7%)
Query: 47 IEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTL------- 99
+E V+ R+AF S SR + R + L + ++++ ++ A + D K+
Sbjct: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
Query: 100 ALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLY 159
+ +I ++N + ++ + T +D Y P+GV +I WN P
Sbjct: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEA----YIQPQPLGVVLIIGAWNYPFV 116
Query: 160 LLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALV 219
L + A+AAGN VI KPSEL+ TA +L KLL + + + ++ G E L
Sbjct: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL- 174
Query: 220 SHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSS 279
I +TG+ + + + +A H ++LELGGK+P I +D +LD
Sbjct: 175 -KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233
Query: 280 FANQGEICLCTSRIFVQKSIYSEFLKRFVEATRK-WKVGIPSDPLVSIGALISKAHLEKV 338
+ N G+ C+ I + S+ ++ + + E ++ + I P +I+ H +++
Sbjct: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESP--DYERIINLRHFKRI 291
Query: 339 RSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTC 398
S L EG +I G D +A ++ PTV+TD+ ++ M EEIFGP+
Sbjct: 292 LS-----LLEGQKIAFGGETD--------EATRYIAPTVLTDVDPKTKVMQEEIFGPILP 338
Query: 399 VVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIR-ELN-LP 456
+VP + +E I N + LA V+S N + R+ + SG V N ++ LN P
Sbjct: 339 IVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFP 398
Query: 457 FGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
FGG+ SSG+G K S+D F+ + +K
Sbjct: 399 FGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 142 bits (357), Expect = 9e-34
Identities = 123/450 (27%), Positives = 210/450 (46%), Gaps = 32/450 (7%)
Query: 47 IEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTL------- 99
+E V+ R+AF S SR + R + L + ++++ ++ A + D K+
Sbjct: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
Query: 100 ALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLY 159
+ +I ++N + ++ + T +D Y P+GV +I WN P
Sbjct: 61 VITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEA----YIQPQPLGVVLIIGAWNYPFV 116
Query: 160 LLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALV 219
L + A+AAGN VI KPSEL+ TA +L KLL + + + ++ G E L
Sbjct: 117 LTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELL- 174
Query: 220 SHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSS 279
I +TG+ + + + +A H ++LELGGK+P I +D +LD
Sbjct: 175 -KQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGK 233
Query: 280 FANQGEICLCTSRIFVQKSIYSEFLKRFVEATRK-WKVGIPSDPLVSIGALISKAHLEKV 338
+ N G+ C+ I + S+ ++ + + E ++ + I P +I+ H +++
Sbjct: 234 YMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESP--DYERIINLRHFKRI 291
Query: 339 RSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTC 398
S L EG +I G D +A ++ PTV+TD+ ++ M EEIFGP+
Sbjct: 292 LS-----LLEGQKIAFGGETD--------EATRYIAPTVLTDVDPKTKVMQEEIFGPILP 338
Query: 399 VVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIR-ELN-LP 456
+VP + +E I N + LA V+S N + R+ + SG V N ++ LN P
Sbjct: 339 IVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFP 398
Query: 457 FGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
FGG+ SSG+G K S+D F+ + +K
Sbjct: 399 FGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 136 bits (343), Expect = 4e-32
Identities = 120/450 (26%), Positives = 210/450 (46%), Gaps = 44/450 (9%)
Query: 45 DEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALART 104
D + ++ REAF + +R + R+ L + L+++ + A ++D K+ +
Sbjct: 2 DPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEV 61
Query: 105 MDIPRS-------VQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLP 157
++ S ++N R + + TQ+D + + P G+ +I+PWN P
Sbjct: 62 SEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSA----FIRKEPFGLVLIIAPWNYP 117
Query: 158 LYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEA 217
L L + A+AAGN V+ KPSE++ +L ++L + V +V G GP+
Sbjct: 118 LNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQ 175
Query: 218 LVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVR 277
L+ H I FTGS + + +A H ++LELGGKNP + D C P TV
Sbjct: 176 LLEH-RFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVD-----DNCDPQTVA 229
Query: 278 SSFA-----NQGEICLCTSRIFVQKSIYSEFLKRFVEA-TRKWKVGIPSDPLVSIGALIS 331
+ A N G+ C+ + + L TR + S P ++G +I+
Sbjct: 230 NRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSP--NLGRIIN 287
Query: 332 KAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPAR-NQAGYFMLPTVITDIKDESCCMTE 390
+ +++R A + CG ++++ + +++ ++ PTV+ D+++ M E
Sbjct: 288 QKQFQRLR----------ALLGCG----RVAIGGQSDESDRYIAPTVLVDVQEMEPVMQE 333
Query: 391 EIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLI 450
EIFGP+ +V S +E IE N + LA +S++ V RV + SG N +
Sbjct: 334 EIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFM 393
Query: 451 RE--LNLPFGGMKSSGIGREGAKDSYDFFT 478
+LPFGG+ +SG+GR K S+D F+
Sbjct: 394 HMTLASLPFGGVGASGMGRYHGKFSFDTFS 423
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 136 bits (343), Expect = 4e-32
Identities = 120/450 (26%), Positives = 210/450 (46%), Gaps = 44/450 (9%)
Query: 45 DEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALART 104
D + ++ REAF + +R + R+ L + L+++ + A ++D K+ +
Sbjct: 2 DPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEV 61
Query: 105 MDIPRS-------VQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLP 157
++ S ++N R + + TQ+D + + P G+ +I+PWN P
Sbjct: 62 SEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSA----FIRKEPFGLVLIIAPWNYP 117
Query: 158 LYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEA 217
L L + A+AAGN V+ KPSE++ +L ++L + V +V G GP+
Sbjct: 118 LNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQ 175
Query: 218 LVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVR 277
L+ H I FTGS + + +A H ++LELGGKNP + D C P TV
Sbjct: 176 LLEH-RFDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVD-----DNCDPQTVA 229
Query: 278 SSFA-----NQGEICLCTSRIFVQKSIYSEFLKRFVEA-TRKWKVGIPSDPLVSIGALIS 331
+ A N G+ C+ + + L TR + S P ++G +I+
Sbjct: 230 NRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSP--NLGRIIN 287
Query: 332 KAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPAR-NQAGYFMLPTVITDIKDESCCMTE 390
+ +++R A + CG ++++ + +++ ++ PTV+ D+++ M E
Sbjct: 288 QKQFQRLR----------ALLGCG----RVAIGGQSDESDRYIAPTVLVDVQEMEPVMQE 333
Query: 391 EIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLI 450
EIFGP+ +V S +E IE N + LA +S++ V RV + SG N +
Sbjct: 334 EIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFM 393
Query: 451 RE--LNLPFGGMKSSGIGREGAKDSYDFFT 478
+LPFGG+ +SG+GR K S+D F+
Sbjct: 394 HMTLASLPFGGVGASGMGRYHGKFSFDTFS 423
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 135 bits (341), Expect = 6e-32
Identities = 114/437 (26%), Positives = 198/437 (45%), Gaps = 24/437 (5%)
Query: 44 KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102
K + A++AA A W + +R+++ + AD+L A++ QGKT+ A
Sbjct: 99 KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 158
Query: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162
+ FRF A ++ + R G ISP+N
Sbjct: 159 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 218
Query: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222
APA+ GN V+ KPS+ + ++ + ++L +AG+PP ++ V GP G+ + S
Sbjct: 219 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 277
Query: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276
+ I+FTGS PT + + + A + +L+ E GGKN + A+++ + T+
Sbjct: 278 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 337
Query: 277 RSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPL-VSIGALISKAHL 335
RS+F G+ C SR++V S++ + R +E + KVG P++ A+I
Sbjct: 338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 397
Query: 336 EKVRSYVKRALAE-GAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394
+++ +++ A + I G D + GYF+ P ++ + M EEIFG
Sbjct: 398 ARIKKWLEHARSSPSLTILAGGKCD-------DSVGYFVEPCIVESKDPQEPIMKEEIFG 450
Query: 395 PV--TCVVPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWL 449
PV V P D +E ++ ++ YGL V+S + V K L+ +G + N
Sbjct: 451 PVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 510
Query: 450 IREL--NLPFGGMKSSG 464
+ PFGG ++SG
Sbjct: 511 TGSIVGQQPFGGARASG 527
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 135 bits (341), Expect = 6e-32
Identities = 114/437 (26%), Positives = 198/437 (45%), Gaps = 24/437 (5%)
Query: 44 KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102
K + A++AA A W + +R+++ + AD+L A++ QGKT+ A
Sbjct: 39 KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 98
Query: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162
+ FRF A ++ + R G ISP+N
Sbjct: 99 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 158
Query: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222
APA+ GN V+ KPS+ + ++ + ++L +AG+PP ++ V GP G+ + S
Sbjct: 159 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 217
Query: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276
+ I+FTGS PT + + + A + +L+ E GGKN + A+++ + T+
Sbjct: 218 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 277
Query: 277 RSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPL-VSIGALISKAHL 335
RS+F G+ C SR++V S++ + R +E + KVG P++ A+I
Sbjct: 278 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 337
Query: 336 EKVRSYVKRALAE-GAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394
+++ +++ A + I G D + GYF+ P ++ + M EEIFG
Sbjct: 338 ARIKKWLEHARSSPSLTILAGGKCD-------DSVGYFVEPCIVESKDPQEPIMKEEIFG 390
Query: 395 PV--TCVVPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWL 449
PV V P D +E ++ ++ YGL V+S + V K L+ +G + N
Sbjct: 391 PVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 450
Query: 450 IREL--NLPFGGMKSSG 464
+ PFGG ++SG
Sbjct: 451 TGSIVGQQPFGGARASG 467
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 135 bits (341), Expect = 6e-32
Identities = 114/437 (26%), Positives = 198/437 (45%), Gaps = 24/437 (5%)
Query: 44 KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102
K + A++AA A W + +R+++ + AD+L A++ QGKT+ A
Sbjct: 99 KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 158
Query: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162
+ FRF A ++ + R G ISP+N
Sbjct: 159 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 218
Query: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222
APA+ GN V+ KPS+ + ++ + ++L +AG+PP ++ V GP G+ + S
Sbjct: 219 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 277
Query: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276
+ I+FTGS PT + + + A + +L+ E GGKN + A+++ + T+
Sbjct: 278 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 337
Query: 277 RSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPL-VSIGALISKAHL 335
RS+F G+ C SR++V S++ + R +E + KVG P++ A+I
Sbjct: 338 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 397
Query: 336 EKVRSYVKRALAE-GAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394
+++ +++ A + I G D + GYF+ P ++ + M EEIFG
Sbjct: 398 ARIKKWLEHARSSPSLTILAGGKCD-------DSVGYFVEPCIVESKDPQEPIMKEEIFG 450
Query: 395 PV--TCVVPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWL 449
PV V P D +E ++ ++ YGL V+S + V K L+ +G + N
Sbjct: 451 PVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 510
Query: 450 IREL--NLPFGGMKSSG 464
+ PFGG ++SG
Sbjct: 511 TGSIVGQQPFGGARASG 527
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 135 bits (339), Expect = 1e-31
Identities = 118/465 (25%), Positives = 198/465 (42%), Gaps = 78/465 (16%)
Query: 10 LENFIDGKFLPCS--SYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQ 67
L ++++GK+L + + DP TGE + +++ AAV+AAR AF WS+
Sbjct: 40 LGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGV 99
Query: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSE 127
R++ L ++A+++++ ES G+ + R D+ + Q + H
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY------HAIQA 153
Query: 128 CTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTA 187
TQ + L P+GV GLI P + W+I PA+A G TV+A S
Sbjct: 154 STQEEALAGWE-----PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPP-ASPAP 207
Query: 188 WMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHC 247
+L +L + G PG++N++ G L+ SQP ++ AP
Sbjct: 208 LLLAQLAGELGPFPGILNVLSGPAS-------------LVPILASQPGIRKVAFCGAPE- 253
Query: 248 KKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRF 307
GG R+ +Q+S++ E ++R
Sbjct: 254 -------GGL----------------------------------RLLIQESVWDEAMRRL 272
Query: 308 VEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARN 367
E + + G D V +GA A + V+ +V+ A ++GAQ++ V P+
Sbjct: 273 QERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDV-----PSER 326
Query: 368 QAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSN 427
F PT+++++ S C E+ PV PF + +E + AN G +A+VWS
Sbjct: 327 P---FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSER 383
Query: 428 VGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKD 472
+G+ + LQ G VW N +R+ ++P GG K SG G D
Sbjct: 384 LGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPD 428
Score = 83.6 bits (205), Expect = 4e-16
Identities = 68/238 (28%), Positives = 112/238 (47%), Gaps = 7/238 (2%)
Query: 13 FIDGKF-LPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSR 71
F+ G+F P + S+G ++ V G +I AV+AA +AFP W+ +SP R+
Sbjct: 480 FVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAA 539
Query: 72 VLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQM 131
+L +A LE+ A + + QG L A ++ S + R + + + Q+
Sbjct: 540 LLWALAAALERRKSTLA-SRLERQGAELKAAEA-EVELSARRLRAW-GARVQAQGHTLQV 596
Query: 132 DHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLC 191
L +R P+GV ++ P PL +APA+A GNTV+ PS + A +C
Sbjct: 597 AGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVC 656
Query: 192 KLLDKAGV-PPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCK 248
+ D A V P G+ N+V G + L H +V + + GS ++ + SA + K
Sbjct: 657 Q--DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLK 712
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 127 bits (320), Expect = 2e-29
Identities = 105/361 (29%), Positives = 174/361 (48%), Gaps = 37/361 (10%)
Query: 127 ECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVT 186
+ TQ+D + + P G+ +I+PWN PL L + A+AAGN V+ KPSE++
Sbjct: 54 KATQLDSA----FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNV 109
Query: 187 AWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPH 246
+L ++L + V +V G GP+ L+ H I FTGS + + +A H
Sbjct: 110 EKILAEVLPQY-VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAKH 166
Query: 247 CKKLSLELGGKNPAIIFEDANLDECIPATVRSSFA-----NQGEICLCTSRIFVQKSIYS 301
++LELGGKNP + D C P TV + A N G+ C+ + +
Sbjct: 167 LTPVTLELGGKNPCYVD-----DNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQE 221
Query: 302 EFLKRFVEA-TRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDK 360
L TR + S P ++G +I++ +++R A + CG +
Sbjct: 222 RLLPALQSTITRFYGDDPQSSP--NLGRIINQKQFQRLR----------ALLGCG----R 265
Query: 361 LSLPAR-NQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGL 419
+++ + +++ ++ PTV+ D+++ M EEIFGP+ +V S +E IE N + L
Sbjct: 266 VAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPL 325
Query: 420 AATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRE--LNLPFGGMKSSGIGREGAKDSYDFF 477
A +S++ V RV + SG N + +LPFGG+ +SG+GR K S+D F
Sbjct: 326 ALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 385
Query: 478 T 478
+
Sbjct: 386 S 386
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 127 bits (320), Expect = 2e-29
Identities = 98/350 (28%), Positives = 174/350 (49%), Gaps = 33/350 (9%)
Query: 142 RAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPP 201
+ P G+ +I+PWN PL L + A+AAG+ V+ KPSE++ T +L ++L + +
Sbjct: 21 KEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY-LDQ 79
Query: 202 GVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAI 261
+V G GP+ L+ H ++ I FTGS + + + H ++LELGGKNP
Sbjct: 80 SCFAVVLG-GPQETGQLLEH-KLDYIFFTGSPRVGKIVMTAATKHLTPVTLELGGKNPCY 137
Query: 262 IFEDANLDECIPATVRSSFA-----NQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKV 316
+ D C P TV + A N G+ C+ + + L ++
Sbjct: 138 VD-----DNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYG 192
Query: 317 GIP-SDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPAR-NQAGYFML 374
P S P ++G +I++ +++R A + CG ++++ + N++ ++
Sbjct: 193 DDPQSSP--NLGRIINQKQFQRLR----------ALLGCG----RVAIGGQSNESDRYIA 236
Query: 375 PTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRV 434
PTV+ D+++ M EEIFGP+ +V S +E I+ N + LA +S++ V+++
Sbjct: 237 PTVLVDVQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQM 296
Query: 435 AKKLQSGLVWTN--CWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKT 482
++ SG N I L++PFGG+ SG+GR K ++D F+ +T
Sbjct: 297 LERTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRT 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,602,785
Number of Sequences: 37866
Number of extensions: 826498
Number of successful extensions: 2104
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1956
Number of HSP's gapped (non-prelim): 45
length of query: 487
length of database: 18,247,518
effective HSP length: 106
effective length of query: 381
effective length of database: 14,233,722
effective search space: 5423048082
effective search space used: 5423048082
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.