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Search of human proteins with 24762239
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
(690 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 1417 0.0
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 1417 0.0
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 1411 0.0
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 689 0.0
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 629 e-180
gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens] 607 e-174
gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens] 607 e-174
gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens] 607 e-174
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 488 e-138
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 485 e-137
gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo sapi... 437 e-122
gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo sapi... 276 5e-74
gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo sapi... 217 3e-56
gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo sapi... 216 7e-56
gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo sapi... 199 7e-51
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 124 3e-28
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 114 2e-25
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 114 2e-25
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 114 2e-25
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 109 1e-23
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 109 1e-23
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 95 2e-19
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 87 5e-17
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 87 7e-17
gi|239582765 ral guanine nucleotide dissociation stimulator-like... 86 1e-16
gi|239582763 ral guanine nucleotide dissociation stimulator-like... 86 1e-16
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 83 1e-15
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 83 1e-15
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 83 1e-15
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 81 4e-15
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 1417 bits (3669), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 1 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 60
MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR
Sbjct: 1 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 60
Query: 61 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 120
NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI
Sbjct: 61 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 120
Query: 121 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV
Sbjct: 121 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
Query: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT
Sbjct: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
Query: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP
Sbjct: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
Query: 301 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 360
ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL
Sbjct: 301 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 360
Query: 361 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 420
TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH
Sbjct: 361 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 420
Query: 421 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 480
IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR
Sbjct: 421 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 480
Query: 481 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 540
AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL
Sbjct: 481 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 540
Query: 541 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 600
VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK
Sbjct: 541 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 600
Query: 601 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 660
ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV
Sbjct: 601 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 660
Query: 661 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 690
HAGVDVVDRGTEFELDQDEGEETRQDGEDG
Sbjct: 661 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 690
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 1417 bits (3669), Expect = 0.0
Identities = 690/690 (100%), Positives = 690/690 (100%)
Query: 1 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 60
MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR
Sbjct: 1 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 60
Query: 61 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 120
NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI
Sbjct: 61 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 120
Query: 121 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV
Sbjct: 121 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
Query: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT
Sbjct: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
Query: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP
Sbjct: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
Query: 301 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 360
ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL
Sbjct: 301 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 360
Query: 361 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 420
TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH
Sbjct: 361 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 420
Query: 421 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 480
IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR
Sbjct: 421 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 480
Query: 481 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 540
AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL
Sbjct: 481 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 540
Query: 541 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 600
VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK
Sbjct: 541 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 600
Query: 601 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 660
ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV
Sbjct: 601 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 660
Query: 661 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 690
HAGVDVVDRGTEFELDQDEGEETRQDGEDG
Sbjct: 661 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 690
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 1411 bits (3652), Expect = 0.0
Identities = 689/690 (99%), Positives = 689/690 (99%), Gaps = 1/690 (0%)
Query: 1 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 60
MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR
Sbjct: 1 MGSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYR 60
Query: 61 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 120
NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI
Sbjct: 61 NATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI 120
Query: 121 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV
Sbjct: 121 SSIPSYDWMRRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
Query: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT
Sbjct: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
Query: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP
Sbjct: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
Query: 301 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 360
ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL
Sbjct: 301 ILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLL 360
Query: 361 TLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 420
TLSLDLYHTEDDIYKLSLVLEPRNSKS PTSPTTPNKPVVPLEWALGVMPKPDPTVINKH
Sbjct: 361 TLSLDLYHTEDDIYKLSLVLEPRNSKS-PTSPTTPNKPVVPLEWALGVMPKPDPTVINKH 419
Query: 421 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 480
IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR
Sbjct: 420 IRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLR 479
Query: 481 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 540
AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL
Sbjct: 480 AKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLL 539
Query: 541 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 600
VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK
Sbjct: 540 VLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHRDLDSRAITLVTGSSRK 599
Query: 601 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 660
ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV
Sbjct: 600 ISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDKAAKDKGFAKWENEKPRV 659
Query: 661 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 690
HAGVDVVDRGTEFELDQDEGEETRQDGEDG
Sbjct: 660 HAGVDVVDRGTEFELDQDEGEETRQDGEDG 689
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 689 bits (1777), Expect = 0.0
Identities = 362/681 (53%), Positives = 471/681 (69%), Gaps = 36/681 (5%)
Query: 6 LGKAATLDELLCTCIEMFDDNGELDNS-YLPRIVLLMHRWYLSSTELAEKLLCMYRNATG 64
L K A+LD+L+ +CI+ FD +G L S L +++L MHR +SS EL +K++ +Y++A
Sbjct: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115
Query: 65 ESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIP 124
++ LKICYF+RYWI +F F +D L EEF+E+ G E H LID + I
Sbjct: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175
Query: 125 SYDWMRRVTQRKK--VSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIH 182
+ DW R++TQR K SKK K LLFDHLEP EL+EHLT+LE KSFRRISF+DYQ+Y+++
Sbjct: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235
Query: 183 GCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLM 242
C++ NPT+ERSIAL NGIS+WVQLMVLS+PTPQ RAEV KFI VA+KL QL+NFNTLM
Sbjct: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295
Query: 243 AVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPIL 302
AV+GGL HSSISRLKET SH+ E+ K EMTEL+SS+ NY NYR+A+ +C FKIPIL
Sbjct: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355
Query: 303 GVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTL 362
GVHLKDLI+++ PD+ E+ KVN+ K+ L +SELV LQ + LE N DL++LLTL
Sbjct: 356 GVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTL 415
Query: 363 SLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIR 422
SLDLY+TED+IY+LS EPRN ++ P TP+KP V ++WA GV PKPDP I+KH++
Sbjct: 416 SLDLYYTEDEIYELSYAREPRNHRA---PPLTPSKPPVVVDWASGVSPKPDPKTISKHVQ 472
Query: 423 KLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAK 482
++V+SVF+NYDHD DGYISQE+FE IAA+FPF SFCV+DKD++GLIS+DE+ AYF+RA
Sbjct: 473 RMVDSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRA- 529
Query: 483 SQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVL 542
S ++ K+G GF HNFQE TYLKPTFC++CAGFLWG+IKQGY+CKDCG NCHKQCKDL+V
Sbjct: 530 SSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVF 589
Query: 543 ACRRFARAPSLSSGHGSLPGSPS----------LPPAQDEVFEFPGVTAGHRDLDS--RA 590
C++ A+ P + + + G S L ++ F FP A +S R
Sbjct: 590 ECKKRAKNPVAPTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRT 649
Query: 591 ITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDK------- 643
I L+ SS+KIS+RL+RA +ATQTE G SG + D
Sbjct: 650 IMLMGVSSQKISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSP 709
Query: 644 --------AAKDKGFAKWENE 656
+ + F KWEN+
Sbjct: 710 TSPCPSPVLVRKRAFVKWENK 730
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 629 bits (1623), Expect = e-180
Identities = 343/681 (50%), Positives = 443/681 (65%), Gaps = 71/681 (10%)
Query: 6 LGKAATLDELLCTCIEMFDDNGELDNS-YLPRIVLLMHRWYLSSTELAEKLLCMYRNATG 64
L K A+LD+L+ +CI+ FD +G L S L +++L MHR +SS EL +K++ +Y++A
Sbjct: 56 LAKGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALA 115
Query: 65 ESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIP 124
++ LKICYF+RYWI +F F +D L EEF+E+ G E H LID + I
Sbjct: 116 KNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN 175
Query: 125 SYDWMRRVTQRKK--VSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIH 182
+ DW R++TQR K SKK K LLFDHLEP EL+EHLT+LE KSFRRISF+DYQ+Y+++
Sbjct: 176 ARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVN 235
Query: 183 GCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLM 242
C++ NPT+ERSIAL NGIS+WVQLMVLS+PTPQ RAEV KFI VA+KL QL+NFNTLM
Sbjct: 236 SCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLM 295
Query: 243 AVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPIL 302
AV+GGL HSSISRLKET SH+ E+ K EMTEL+SS+ NY NYR+A+ +C FKIPIL
Sbjct: 296 AVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPIL 355
Query: 303 GVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTL 362
GVHLKDLI+++ PD+ E+ KVN+ K+ L +SELV LQ + LE N DL++LLTL
Sbjct: 356 GVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTL 415
Query: 363 SLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIR 422
SLDLY+TED+IY+LS EPRN ++
Sbjct: 416 SLDLYYTEDEIYELSYAREPRNHRA----------------------------------- 440
Query: 423 KLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAK 482
SVF+NYDHD DGYISQE+FE IAA+FPF SFCV+DKD++GLIS+DE+ AYF+RA
Sbjct: 441 ---PSVFKNYDHDQDGYISQEEFEKIAASFPF--SFCVMDKDREGLISRDEITAYFMRA- 494
Query: 483 SQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVL 542
S ++ K+G GF HNFQE TYLKPTFC++CAGFLWG+IKQGY+CKDCG NCHKQCKDL+V
Sbjct: 495 SSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVF 554
Query: 543 ACRRFARAPSLSSGHGSLPGSPS----------LPPAQDEVFEFPGVTAGHRDLDS--RA 590
C++ A+ P + + + G S L ++ F FP A +S R
Sbjct: 555 ECKKRAKNPVAPTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRT 614
Query: 591 ITLVTGSSRKISVRLQRATTSQATQTEPVWSEAGWGDSGSHTFPKMKSKFHDK------- 643
I L+ SS+KIS+RL+RA +ATQTE G SG + D
Sbjct: 615 IMLMGVSSQKISLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSP 674
Query: 644 --------AAKDKGFAKWENE 656
+ + F KWEN+
Sbjct: 675 TSPCPSPVLVRKRAFVKWENK 695
>gi|24797103 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 607 bits (1566), Expect = e-174
Identities = 312/589 (52%), Positives = 407/589 (69%), Gaps = 12/589 (2%)
Query: 2 GSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRN 61
G+ L K T++ELL CIE FDD+G++ + L R+ L+MH WY+ S++LA KLL +Y+
Sbjct: 3 GTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQ 62
Query: 62 ATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDIS 121
+ ++ N ++K C+ +RYWI FPAEF+L+ L +E + + Q G +H SLIDI
Sbjct: 63 SRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDID 122
Query: 122 SIPSYDWMRRVTQRKKVS-KKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
S+P+Y W R+VTQR V KK K LLFDHLEP+ELAEHLT+LE++SF +I F DY S+V
Sbjct: 123 SVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFV 182
Query: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
HGC +NP LER I+LFN +S+WVQLM+LSKPT QRA VIT F++VA+KLLQL+NFNT
Sbjct: 183 THGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNT 242
Query: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
LMAVVGGLSHSSISRLKETHSH+S E K W +TELV++ GNY NYR+ A C GF+ P
Sbjct: 243 LMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFP 302
Query: 301 ILGVHLKDLIAVHVIFPDWTE--ENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358
ILGVHLKDL+A+ + PDW + ++N KM QL L EL + + ++ N DL++
Sbjct: 303 ILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLS 362
Query: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTT---PNKPVVPLEWALGVMPKPDPT 415
LLT+SLD Y TED++Y+LSL EPR SKS PTSPT+ P +P V EW PK D
Sbjct: 363 LLTVSLDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQA 421
Query: 416 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMM 475
++ +HI K+VESVFRN+D D DG+ISQE+F+ I NFP+L +F LD++QDG IS++EM+
Sbjct: 422 LVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMV 481
Query: 476 AYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQ 535
+YFLR+ S L +M GF+HNFQE L+P C HC + GI KQG KC+ CG NCHKQ
Sbjct: 482 SYFLRSSSVLGGRM--GFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQ 539
Query: 536 CKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHR 584
CKD L + CRR A++ SL GS P + F F G R
Sbjct: 540 CKDRLSVECRRRAQSVSL---EGSAPSPSPMHSHHHRAFSFSLPRPGRR 585
>gi|149158729 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 607 bits (1566), Expect = e-174
Identities = 312/589 (52%), Positives = 407/589 (69%), Gaps = 12/589 (2%)
Query: 2 GSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRN 61
G+ L K T++ELL CIE FDD+G++ + L R+ L+MH WY+ S++LA KLL +Y+
Sbjct: 3 GTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQ 62
Query: 62 ATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDIS 121
+ ++ N ++K C+ +RYWI FPAEF+L+ L +E + + Q G +H SLIDI
Sbjct: 63 SRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDID 122
Query: 122 SIPSYDWMRRVTQRKKVS-KKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
S+P+Y W R+VTQR V KK K LLFDHLEP+ELAEHLT+LE++SF +I F DY S+V
Sbjct: 123 SVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFV 182
Query: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
HGC +NP LER I+LFN +S+WVQLM+LSKPT QRA VIT F++VA+KLLQL+NFNT
Sbjct: 183 THGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNT 242
Query: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
LMAVVGGLSHSSISRLKETHSH+S E K W +TELV++ GNY NYR+ A C GF+ P
Sbjct: 243 LMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFP 302
Query: 301 ILGVHLKDLIAVHVIFPDWTE--ENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358
ILGVHLKDL+A+ + PDW + ++N KM QL L EL + + ++ N DL++
Sbjct: 303 ILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLS 362
Query: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTT---PNKPVVPLEWALGVMPKPDPT 415
LLT+SLD Y TED++Y+LSL EPR SKS PTSPT+ P +P V EW PK D
Sbjct: 363 LLTVSLDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQA 421
Query: 416 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMM 475
++ +HI K+VESVFRN+D D DG+ISQE+F+ I NFP+L +F LD++QDG IS++EM+
Sbjct: 422 LVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMV 481
Query: 476 AYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQ 535
+YFLR+ S L +M GF+HNFQE L+P C HC + GI KQG KC+ CG NCHKQ
Sbjct: 482 SYFLRSSSVLGGRM--GFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQ 539
Query: 536 CKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHR 584
CKD L + CRR A++ SL GS P + F F G R
Sbjct: 540 CKDRLSVECRRRAQSVSL---EGSAPSPSPMHSHHHRAFSFSLPRPGRR 585
>gi|149158727 RAS guanyl releasing protein 2 [Homo sapiens]
Length = 609
Score = 607 bits (1566), Expect = e-174
Identities = 312/589 (52%), Positives = 407/589 (69%), Gaps = 12/589 (2%)
Query: 2 GSSGLGKAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRN 61
G+ L K T++ELL CIE FDD+G++ + L R+ L+MH WY+ S++LA KLL +Y+
Sbjct: 3 GTLDLDKGCTVEELLRGCIEAFDDSGKVRDPQLVRMFLMMHPWYIPSSQLAAKLLHIYQQ 62
Query: 62 ATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDIS 121
+ ++ N ++K C+ +RYWI FPAEF+L+ L +E + + Q G +H SLIDI
Sbjct: 63 SRKDNSNSLQVKTCHLVRYWISAFPAEFDLNPELAEQIKELKALLDQEGNRRHSSLIDID 122
Query: 122 SIPSYDWMRRVTQRKKVS-KKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYV 180
S+P+Y W R+VTQR V KK K LLFDHLEP+ELAEHLT+LE++SF +I F DY S+V
Sbjct: 123 SVPTYKWKRQVTQRNPVGQKKRKMSLLFDHLEPMELAEHLTYLEYRSFCKILFQDYHSFV 182
Query: 181 IHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNT 240
HGC +NP LER I+LFN +S+WVQLM+LSKPT QRA VIT F++VA+KLLQL+NFNT
Sbjct: 183 THGCTVDNPVLERFISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNT 242
Query: 241 LMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIP 300
LMAVVGGLSHSSISRLKETHSH+S E K W +TELV++ GNY NYR+ A C GF+ P
Sbjct: 243 LMAVVGGLSHSSISRLKETHSHVSPETIKLWEGLTELVTATGNYGNYRRRLAACVGFRFP 302
Query: 301 ILGVHLKDLIAVHVIFPDWTE--ENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358
ILGVHLKDL+A+ + PDW + ++N KM QL L EL + + ++ N DL++
Sbjct: 303 ILGVHLKDLVALQLALPDWLDPARTRLNGAKMKQLFSILEELAMVTSLRPPVQANPDLLS 362
Query: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTT---PNKPVVPLEWALGVMPKPDPT 415
LLT+SLD Y TED++Y+LSL EPR SKS PTSPT+ P +P V EW PK D
Sbjct: 363 LLTVSLDQYQTEDELYQLSLQREPR-SKSSPTSPTSCTPPPRPPVLEEWTSAAKPKLDQA 421
Query: 416 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMM 475
++ +HI K+VESVFRN+D D DG+ISQE+F+ I NFP+L +F LD++QDG IS++EM+
Sbjct: 422 LVVEHIEKMVESVFRNFDVDGDGHISQEEFQIIRGNFPYLSAFGDLDQNQDGCISREEMV 481
Query: 476 AYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQ 535
+YFLR+ S L +M GF+HNFQE L+P C HC + GI KQG KC+ CG NCHKQ
Sbjct: 482 SYFLRSSSVLGGRM--GFVHNFQESNSLRPVACRHCKALILGIYKQGLKCRACGVNCHKQ 539
Query: 536 CKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQDEVFEFPGVTAGHR 584
CKD L + CRR A++ SL GS P + F F G R
Sbjct: 540 CKDRLSVECRRRAQSVSL---EGSAPSPSPMHSHHHRAFSFSLPRPGRR 585
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 488 bits (1257), Expect = e-138
Identities = 256/554 (46%), Positives = 359/554 (64%), Gaps = 22/554 (3%)
Query: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
Query: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDWMRR 131
L+IC+ +RYW+++ P + D L + F ++ G L D S +P
Sbjct: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLPG------ 172
Query: 132 VTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTL 191
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P L
Sbjct: 173 ------LGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPAL 226
Query: 192 ERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHS 251
E S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL HS
Sbjct: 227 EGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHS 286
Query: 252 SISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIA 311
+ISRLK++H+HLS + TK E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL++
Sbjct: 287 AISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVS 346
Query: 312 VHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTED 371
+H PD + ++++ K++ L + L ELV+LQ N DL++LLTLSLDL++TED
Sbjct: 347 LHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTED 406
Query: 372 DIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRN 431
+IY+LS EPR KS P SP N P+V +EWA GV PKPD + +H+ +LVESVF+N
Sbjct: 407 EIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKN 463
Query: 432 YDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMG 490
YD + G ISQEDFE ++ NFPF + G S++E+ Y LRA S + K+G
Sbjct: 464 YDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLG 522
Query: 491 PGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARA 550
F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++ A
Sbjct: 523 LAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA 582
Query: 551 PSLSSGHGSLPGSP 564
G PG+P
Sbjct: 583 ----KGDAGPPGAP 592
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 485 bits (1248), Expect = e-137
Identities = 256/556 (46%), Positives = 359/556 (64%), Gaps = 12/556 (2%)
Query: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
Query: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
Query: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
Query: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
Query: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDL 309
HS+ISRLK++H+HLS + TK E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL
Sbjct: 299 HSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDL 358
Query: 310 IAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHT 369
+++H PD + ++++ K++ L + L ELV+LQ N DL++LLTLSLDL++T
Sbjct: 359 VSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYT 418
Query: 370 EDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVF 429
ED+IY+LS EPR KS P SP N P+V +EWA GV PKPD + +H+ +LVESVF
Sbjct: 419 EDEIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVF 475
Query: 430 RNYDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCK 488
+NYD + G ISQEDFE ++ NFPF + G S++E+ Y LRA S + K
Sbjct: 476 KNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSK 534
Query: 489 MGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFA 548
+G F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++
Sbjct: 535 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP 594
Query: 549 RAPSLSSGHGSLPGSP 564
A G PG+P
Sbjct: 595 GA----KGDAGPPGAP 606
>gi|226246581 RAS guanyl releasing protein 4 isoform e [Homo
sapiens]
Length = 639
Score = 437 bits (1124), Expect = e-122
Identities = 241/556 (43%), Positives = 338/556 (60%), Gaps = 46/556 (8%)
Query: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
Query: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
Query: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+
Sbjct: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT----------------- 221
Query: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 222 -----------------VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 264
Query: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDL 309
HS+ISRLK++H+HLS + TK E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL
Sbjct: 265 HSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDL 324
Query: 310 IAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHT 369
+++H PD + ++++ K++ L + L ELV+LQ N DL++LLTLSLDL++T
Sbjct: 325 VSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYT 384
Query: 370 EDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVF 429
ED+IY+LS EPR KS P SP N P+V +EWA GV PKPD + +H+ +LVESVF
Sbjct: 385 EDEIYELSYAREPRCPKSLPPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVF 441
Query: 430 RNYDHDHDGYISQEDFESIAANFPF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCK 488
+NYD + G ISQEDFE ++ NFPF + G S++E+ Y LRA S + K
Sbjct: 442 KNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSK 500
Query: 489 MGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFA 548
+G F+H F E+T+ KPTFC+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++
Sbjct: 501 LGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRP 560
Query: 549 RAPSLSSGHGSLPGSP 564
A G PG+P
Sbjct: 561 GA----KGDAGPPGAP 572
>gi|226246586 RAS guanyl releasing protein 4 isoform g [Homo
sapiens]
Length = 576
Score = 276 bits (706), Expect = 5e-74
Identities = 137/293 (46%), Positives = 195/293 (66%), Gaps = 9/293 (3%)
Query: 273 EMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQ 332
E+TEL++S+ NY YR+ +A C GF++P+LGVHLKDL+++H PD + ++++ K++
Sbjct: 225 ELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNN 284
Query: 333 LSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSP 392
L + L ELV+LQ N DL++LLTLSLDL++TED+IY+LS EPR KS P SP
Sbjct: 285 LYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSP 344
Query: 393 TTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANF 452
N P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NF
Sbjct: 345 F--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNF 401
Query: 453 PF-LDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHC 511
PF + G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C
Sbjct: 402 PFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSC 460
Query: 512 AGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
+GFLWG+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 461 SGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 509
Score = 102 bits (254), Expect = 1e-21
Identities = 62/163 (38%), Positives = 88/163 (53%), Gaps = 3/163 (1%)
Query: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
Query: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
Query: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRIS 172
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+
Sbjct: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAIT 221
>gi|226246579 RAS guanyl releasing protein 4 isoform d [Homo
sapiens]
Length = 604
Score = 217 bits (552), Expect = 3e-56
Identities = 123/275 (44%), Positives = 170/275 (61%), Gaps = 9/275 (3%)
Query: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
Query: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
Query: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
Query: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
Query: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNY 284
HS+ISRLK++H+HLS + TK ELV+ G +
Sbjct: 299 HSAISRLKDSHAHLSPDSTK------ELVALQGQH 327
Score = 211 bits (538), Expect = 1e-54
Identities = 109/227 (48%), Positives = 147/227 (64%), Gaps = 9/227 (3%)
Query: 339 ELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKP 398
ELV+LQ N DL++LLTLSLDL++TED+IY+LS EPR KS P SP N P
Sbjct: 319 ELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPF--NAP 376
Query: 399 VVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFL-DS 457
+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NFPF
Sbjct: 377 LV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHG 435
Query: 458 FCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWG 517
+ G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C+GFLWG
Sbjct: 436 LHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWG 494
Query: 518 IIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 495 VTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 537
>gi|226246577 RAS guanyl releasing protein 4 isoform c [Homo
sapiens]
Length = 581
Score = 216 bits (549), Expect = 7e-56
Identities = 119/260 (45%), Positives = 164/260 (63%), Gaps = 3/260 (1%)
Query: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
Query: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
Query: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP 189
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ D +SYV+ G + P
Sbjct: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCP 238
Query: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
LE S+ L N +S+WVQ+MVLS+P P QRA+V+ KFI+VA++L QL+NFNTLMAV GGL
Sbjct: 239 ALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLC 298
Query: 250 HSSISRLKETHSHLSSEVTK 269
HS+ISRLK++H+HLS + TK
Sbjct: 299 HSAISRLKDSHAHLSPDSTK 318
Score = 197 bits (500), Expect = 4e-50
Identities = 103/228 (45%), Positives = 143/228 (62%), Gaps = 14/228 (6%)
Query: 338 SELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNK 397
S + L+++ HL P+ LSLDL++TED+IY+LS EPR KS P SP N
Sbjct: 300 SAISRLKDSHAHLSPDST-----KLSLDLFYTEDEIYELSYAREPRCPKSLPPSPF--NA 352
Query: 398 PVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFL-D 456
P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE ++ NFPF
Sbjct: 353 PLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACH 411
Query: 457 SFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLW 516
+ G S++E+ Y LRA S + K+G F+H F E+T+ KPTFC+ C+GFLW
Sbjct: 412 GLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLW 470
Query: 517 GIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
G+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 471 GVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 514
>gi|226246584 RAS guanyl releasing protein 4 isoform f [Homo
sapiens]
Length = 484
Score = 199 bits (506), Expect = 7e-51
Identities = 104/237 (43%), Positives = 145/237 (61%), Gaps = 9/237 (3%)
Query: 329 KMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQ 388
K ++S+ L + + A H +TLSLDL++TED+IY+LS EPR KS
Sbjct: 189 KKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLSLDLFYTEDEIYELSYAREPRCPKSL 248
Query: 389 PTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESI 448
P SP N P+V +EWA GV PKPD + +H+ +LVESVF+NYD + G ISQEDFE +
Sbjct: 249 PPSPF--NAPLV-VEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERL 305
Query: 449 AANFPFL-DSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTF 507
+ NFPF + G S++E+ Y LRA S + K+G F+H F E+T+ KPTF
Sbjct: 306 SGNFPFACHGLHPPPRQGRGSFSREELTGYLLRA-SAICSKLGLAFLHTFHEVTFRKPTF 364
Query: 508 CEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSP 564
C+ C+GFLWG+ KQGY+C++CG CHK C+D + + C++ A G PG+P
Sbjct: 365 CDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGA----KGDAGPPGAP 417
Score = 102 bits (255), Expect = 9e-22
Identities = 62/165 (37%), Positives = 89/165 (53%), Gaps = 3/165 (1%)
Query: 13 DELLCTCIEMFDDNGEL-DNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESCNEFR 71
DELL CI+ FD G L ++ +VL MH W L S +LA +LL Y+ ATG++ R
Sbjct: 59 DELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRR 118
Query: 72 LKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDISSI--PSYDWM 129
L+IC+ +RYW+++ P + D L + F ++ G L D S + P
Sbjct: 119 LQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGP 178
Query: 130 RRVTQRKKVSKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFT 174
+ KK K LLFDHLE ELA+HLT+LE +SF+ I+ +
Sbjct: 179 PLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITLS 223
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 124 bits (311), Expect = 3e-28
Identities = 86/320 (26%), Positives = 159/320 (49%), Gaps = 11/320 (3%)
Query: 73 KICYFMRYWILKFPAEFNLD----LGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
++ +R+W+ K +F L+ + ++ + EE L E+ + + ++ S D
Sbjct: 917 RVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRAL-SQDD 975
Query: 129 MRRVTQRKKVSKKGKACL---LFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHG 183
+ + + + C+ F+ L +ELAE +T L+H FR I + ++ Q ++
Sbjct: 976 QDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLD 1035
Query: 184 CLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMA 243
E P + ++ FN +S V +++ RA I K++ VA L N+N ++
Sbjct: 1036 KNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLE 1095
Query: 244 VVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILG 303
+ L+ S+I RLK+T + +S + +++ + VSS G + N R+ +C+ +P LG
Sbjct: 1096 ITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLG 1155
Query: 304 VHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLS 363
++L DL + P++TEE VN KM +S + E+ Q S+ ++ + L L
Sbjct: 1156 MYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYL-LD 1214
Query: 364 LDLYHTEDDIYKLSLVLEPR 383
DL ED +Y+LSL +EPR
Sbjct: 1215 KDLIIDEDTLYELSLKIEPR 1234
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 114 bits (286), Expect = 2e-25
Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)
Query: 73 KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
++ +R+W+ K +F L +I EE L E+ + I ++ D
Sbjct: 937 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 996
Query: 129 MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184
+++++ +G F++ +E+AE LT L+H F++I + ++ Q ++
Sbjct: 997 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 1056
Query: 185 LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244
E P + ++ FN IS + ++ R I K++ VA L N+N ++ +
Sbjct: 1057 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 1116
Query: 245 VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304
++ S+I RLK+T +S + +++ +LVSS G + N R+A +CD +P LG+
Sbjct: 1117 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 1176
Query: 305 HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364
+L DL + P++TE+ VN KM +S + E+ Q ++ +E + L L
Sbjct: 1177 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 1235
Query: 365 DLYHTEDDIYKLSLVLEPR 383
E+ +Y+ SL +EP+
Sbjct: 1236 SFVMDEESLYESSLRIEPK 1254
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 114 bits (286), Expect = 2e-25
Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)
Query: 73 KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
++ +R+W+ K +F L +I EE L E+ + I ++ D
Sbjct: 953 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 1012
Query: 129 MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184
+++++ +G F++ +E+AE LT L+H F++I + ++ Q ++
Sbjct: 1013 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 1072
Query: 185 LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244
E P + ++ FN IS + ++ R I K++ VA L N+N ++ +
Sbjct: 1073 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 1132
Query: 245 VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304
++ S+I RLK+T +S + +++ +LVSS G + N R+A +CD +P LG+
Sbjct: 1133 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 1192
Query: 305 HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364
+L DL + P++TE+ VN KM +S + E+ Q ++ +E + L L
Sbjct: 1193 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 1251
Query: 365 DLYHTEDDIYKLSLVLEPR 383
E+ +Y+ SL +EP+
Sbjct: 1252 SFVMDEESLYESSLRIEPK 1270
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 114 bits (286), Expect = 2e-25
Identities = 80/319 (25%), Positives = 153/319 (47%), Gaps = 9/319 (2%)
Query: 73 KICYFMRYWILKFPAEFN----LDLGLIRMTEEFREVASQLGYEKHVSLIDISSIPSYDW 128
++ +R+W+ K +F L +I EE L E+ + I ++ D
Sbjct: 169 RVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDP 228
Query: 129 MRRVTQRKKVSK--KGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY--QSYVIHGC 184
+++++ +G F++ +E+AE LT L+H F++I + ++ Q ++
Sbjct: 229 GDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK 288
Query: 185 LENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAV 244
E P + ++ FN IS + ++ R I K++ VA L N+N ++ +
Sbjct: 289 NERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEI 348
Query: 245 VGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGV 304
++ S+I RLK+T +S + +++ +LVSS G + N R+A +CD +P LG+
Sbjct: 349 TSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGM 408
Query: 305 HLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSL 364
+L DL + P++TE+ VN KM +S + E+ Q ++ +E + L L
Sbjct: 409 YLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL-LDQ 467
Query: 365 DLYHTEDDIYKLSLVLEPR 383
E+ +Y+ SL +EP+
Sbjct: 468 SFVMDEESLYESSLRIEPK 486
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 109 bits (272), Expect = 1e-23
Identities = 92/364 (25%), Positives = 170/364 (46%), Gaps = 24/364 (6%)
Query: 39 LLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRM 98
L +R ++S EL +KL Y + + F+ ++ + +++ E L L+ +
Sbjct: 738 LTTYRTFISPEELIKKLQYRYEKFS-PFADTFKKRVSKNTFFVLVRVVDE----LCLVEL 792
Query: 99 TEEFREVASQLGYEK----HVSLIDI------SSIPSYDWMRRVTQRKKVSKKGKACL-- 146
TEE ++ +L + +SL + + +R T + ++ +G A
Sbjct: 793 TEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPG 852
Query: 147 LFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQ 206
E+AE LT L+ + F +I + + E +P L + FN +S WV+
Sbjct: 853 TLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVR 912
Query: 207 LMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSE 266
+++ + Q R ++ KFI + K L +L NFN+ +A++ L + I RL+ +
Sbjct: 913 SIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE-----WQKQ 967
Query: 267 VTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVN 326
++ E L+ S+ ++ YR A ++ + IP LG+ L+DL VH+ PD+ + KVN
Sbjct: 968 TSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVN 1026
Query: 327 IVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSK 386
K Q L + Q A + + N D+IN D + E+ +++LSL ++PRN
Sbjct: 1027 FSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPRNIT 1085
Query: 387 SQPT 390
+ T
Sbjct: 1086 RRKT 1089
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 109 bits (272), Expect = 1e-23
Identities = 92/364 (25%), Positives = 170/364 (46%), Gaps = 24/364 (6%)
Query: 39 LLMHRWYLSSTELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRM 98
L +R ++S EL +KL Y + + F+ ++ + +++ E L L+ +
Sbjct: 720 LTTYRTFISPEELIKKLQYRYEKFS-PFADTFKKRVSKNTFFVLVRVVDE----LCLVEL 774
Query: 99 TEEFREVASQLGYEK----HVSLIDI------SSIPSYDWMRRVTQRKKVSKKGKACL-- 146
TEE ++ +L + +SL + + +R T + ++ +G A
Sbjct: 775 TEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQPLAARGVAARPG 834
Query: 147 LFDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQ 206
E+AE LT L+ + F +I + + E +P L + FN +S WV+
Sbjct: 835 TLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVR 894
Query: 207 LMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSE 266
+++ + Q R ++ KFI + K L +L NFN+ +A++ L + I RL+ +
Sbjct: 895 SIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE-----WQKQ 949
Query: 267 VTKNWNEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVN 326
++ E L+ S+ ++ YR A ++ + IP LG+ L+DL VH+ PD+ + KVN
Sbjct: 950 TSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYI-DGKVN 1008
Query: 327 IVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSK 386
K Q L + Q A + + N D+IN D + E+ +++LSL ++PRN
Sbjct: 1009 FSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSD-HLAEEALWELSLKIKPRNIT 1067
Query: 387 SQPT 390
+ T
Sbjct: 1068 RRKT 1071
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 94.7 bits (234), Expect = 2e-19
Identities = 120/469 (25%), Positives = 195/469 (41%), Gaps = 98/469 (20%)
Query: 8 KAATLDELLCTCIEMFDDNGELDNSYLPRIVLLMHRWYLSSTELAEKLLCMYRNATGESC 67
KA TL++L+ + F DN D +Y+ I L +R + S+ E+ E LL Y N T +C
Sbjct: 105 KAGTLEKLVENLLTAFGDN---DFTYIS-IFLSTYRGFASTKEVLELLLDRYGNLTSPNC 160
Query: 68 NE------------FRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHV 115
E R I +R W L + E+FRE +K +
Sbjct: 161 EEDGSQSSSESKMVIRNAIASILRAW-------------LDQCAEDFREPPHFPCLQKLL 207
Query: 116 SLIDISSIPSYDWMRRVTQRKKVSKKGKA--------CLLF-----DHLEPIELAEHLTF 162
+ +P D RR + +K + + F + LE E AE F
Sbjct: 208 DYLT-RMMPGSDPERRAQNLLEQFQKQEVETDNGLPNTISFSLEEEEELEGGESAEFTCF 266
Query: 163 LEHKSFRRISFTDYQSY---VIHGCL----------ENN---PTLERSIALFNGISKWVQ 206
E ++++ D Q + V H CL EN PT+ +I+ FN ++K V
Sbjct: 267 SEDLVAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVV 326
Query: 207 LMVLS--KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLS 264
+L + QQRA++I K+IN+A + LKNF++L A+V L +SI RLK+T + +
Sbjct: 327 STILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVP 386
Query: 265 SEVTKNWNEMTELVSSNGNYCNYRK--------AFADCDGF------------------- 297
+ + E++++ S + N+ R+ FA+ D
Sbjct: 387 RDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMG 446
Query: 298 ----KIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNA--SHHLE 351
+P LG L DL + D+ E +N K + ++++ LQ+A S+ +
Sbjct: 447 VMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVIAQIKLLQSACNSYCMT 506
Query: 352 PNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVV 400
P+ I L TE++ Y LS +E S T+ P K +V
Sbjct: 507 PDQKFIQWFQRQQLL--TEEESYALSCEIEAAADAS--TTSPKPRKSMV 551
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 87.0 bits (214), Expect = 5e-17
Identities = 75/269 (27%), Positives = 129/269 (47%), Gaps = 22/269 (8%)
Query: 139 SKKGKACLLFDHLE--PIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENN--PTLERS 194
+ K ++FD L+ P E A +T ++ F+ I + S +++ P +
Sbjct: 35 ASKSYDAVVFDVLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAF 94
Query: 195 IALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSIS 254
FN +S WV +L+ T + RAE+++ F+ +AKKLL+L N ++LM+VV L + I
Sbjct: 95 TRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIF 154
Query: 255 RLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGF-KIPILGVHLKDLIAVH 313
RL +T + L+ + + ++ L+S NY R+ IP LG++L DLI +
Sbjct: 155 RLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYID 214
Query: 314 VIFP-------DWTEENKVN----IVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTL 362
+P + N++N I+ Q+S + L +L + +L+ + L
Sbjct: 215 SAYPASGSIMENEQRSNQMNNILRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKF 274
Query: 363 SLDLYHTEDDIYKLSLVLEPRNSKSQPTS 391
EDD YKLSL +EP +S + S
Sbjct: 275 ------VEDDNYKLSLRIEPGSSSPRLVS 297
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 86.7 bits (213), Expect = 7e-17
Identities = 94/338 (27%), Positives = 147/338 (43%), Gaps = 33/338 (9%)
Query: 140 KKGKACLLFDHLE--PIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIAL 197
KK ++FD L+ P E A +T ++ F+ I D S E + ++A
Sbjct: 35 KKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQ-PDELSSCGWNKKEKYSSAPNAVAF 93
Query: 198 ---FNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSIS 254
FN +S WV +L T + RAEV++ +I AKKL +L N + LMAVV GL + I
Sbjct: 94 TRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIF 153
Query: 255 RLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCDGFK-IPILGVHLKDLIAVH 313
RL +T + LS + + ++ ++S NY R + IP LG++L DL +
Sbjct: 154 RLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYID 213
Query: 314 VIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYH----- 368
+P T N + + ++ L + LQ + + P + + S+
Sbjct: 214 SAYPS-TGSILENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKF 272
Query: 369 TEDDIYKLSLVLEPRNSKSQP-------------TSPTTPNKPVVPLEWALGVMPKPDPT 415
EDD YKLSL +EP S + SP + K V E AL P P
Sbjct: 273 VEDDNYKLSLKIEPGTSTPRSAASREDLVGPEVGASPQSGRKSVA-AEGALLPQTPPSPR 331
Query: 416 VINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFP 453
+ H + S+ N+ H ++ +F+S A FP
Sbjct: 332 NLIPHGHRKCHSLGYNFIHK----MNTAEFKS--ATFP 363
>gi|239582765 ral guanine nucleotide dissociation stimulator-like 3
isoform 1 [Homo sapiens]
Length = 716
Score = 85.5 bits (210), Expect = 1e-16
Identities = 69/267 (25%), Positives = 125/267 (46%), Gaps = 32/267 (11%)
Query: 155 ELAEHLTFLEHKSFRRISFTDYQSYVIH-----GCLENNPTLERSIALFNGISKWVQLMV 209
E+AE LT ++ + F ++ + V G +PT+ ++A FN ++ V V
Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
Query: 210 LSKP--TPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEV 267
L P QRA+ + K+I +A++ +L+NF++L A++ L + I RLK + +S E
Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
Query: 268 TKNWNEMTELVSSNGNYCNYRKAFADCDGFK--------------------IPILGVHLK 307
+ +++++ S N+ + R+ + + +P LG L
Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
Query: 308 DLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLD 365
DL+ + PD E + +N K + L+ + LQ S+ L P+ ++ L
Sbjct: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
Query: 366 LYHTEDDIYKLSLVLEPRNSKSQPTSP 392
L TE+ Y+LS V+EP + S P+SP
Sbjct: 490 L--TEEQSYRLSRVIEP-PAASCPSSP 513
>gi|239582763 ral guanine nucleotide dissociation stimulator-like 3
isoform 2 [Homo sapiens]
Length = 710
Score = 85.5 bits (210), Expect = 1e-16
Identities = 69/267 (25%), Positives = 125/267 (46%), Gaps = 32/267 (11%)
Query: 155 ELAEHLTFLEHKSFRRISFTDYQSYVIH-----GCLENNPTLERSIALFNGISKWVQLMV 209
E+AE LT ++ + F ++ + V G +PT+ ++A FN ++ V V
Sbjct: 250 EVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSV 309
Query: 210 LSKP--TPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEV 267
L P QRA+ + K+I +A++ +L+NF++L A++ L + I RLK + +S E
Sbjct: 310 LGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREP 369
Query: 268 TKNWNEMTELVSSNGNYCNYRKAFADCDGFK--------------------IPILGVHLK 307
+ +++++ S N+ + R+ + + +P LG L
Sbjct: 370 LSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLT 429
Query: 308 DLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQN--ASHHLEPNMDLINLLTLSLD 365
DL+ + PD E + +N K + L+ + LQ S+ L P+ ++ L
Sbjct: 430 DLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQ 489
Query: 366 LYHTEDDIYKLSLVLEPRNSKSQPTSP 392
L TE+ Y+LS V+EP + S P+SP
Sbjct: 490 L--TEEQSYRLSRVIEP-PAASCPSSP 513
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 82.8 bits (203), Expect = 1e-15
Identities = 70/240 (29%), Positives = 109/240 (45%), Gaps = 10/240 (4%)
Query: 155 ELAEHLTFLEHKSFRRISFTDYQSYVI---HGCLENNPTLERSIALFNGISKWVQLMVLS 211
+LA LT + F I + YV+ H LER + FN + WV +
Sbjct: 623 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 682
Query: 212 KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNW 271
P P RA+++ KFI +A L + KN N+ AV+ GLS+S+ISRL T L +V K +
Sbjct: 683 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 742
Query: 272 NEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMH 331
+ + L+ + N+ YR A A IP + + LKD+ +H EN +N KM
Sbjct: 743 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHE-GNHTLVENLINFEKMR 801
Query: 332 QLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTS 391
++ L + SH+ P ++ L + H + + ++S E S P S
Sbjct: 802 MMARAARMLHHCR--SHNPVP----LSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPAS 855
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 82.8 bits (203), Expect = 1e-15
Identities = 70/240 (29%), Positives = 109/240 (45%), Gaps = 10/240 (4%)
Query: 155 ELAEHLTFLEHKSFRRISFTDYQSYVI---HGCLENNPTLERSIALFNGISKWVQLMVLS 211
+LA LT + F I + YV+ H LER + FN + WV +
Sbjct: 623 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 682
Query: 212 KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNW 271
P P RA+++ KFI +A L + KN N+ AV+ GLS+S+ISRL T L +V K +
Sbjct: 683 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 742
Query: 272 NEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMH 331
+ + L+ + N+ YR A A IP + + LKD+ +H EN +N KM
Sbjct: 743 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHE-GNHTLVENLINFEKMR 801
Query: 332 QLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTS 391
++ L + SH+ P ++ L + H + + ++S E S P S
Sbjct: 802 MMARAARMLHHCR--SHNPVP----LSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPAS 855
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 82.8 bits (203), Expect = 1e-15
Identities = 70/240 (29%), Positives = 109/240 (45%), Gaps = 10/240 (4%)
Query: 155 ELAEHLTFLEHKSFRRISFTDYQSYVI---HGCLENNPTLERSIALFNGISKWVQLMVLS 211
+LA LT + F I + YV+ H LER + FN + WV +
Sbjct: 665 DLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCL 724
Query: 212 KPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNW 271
P P RA+++ KFI +A L + KN N+ AV+ GLS+S+ISRL T L +V K +
Sbjct: 725 CPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLY 784
Query: 272 NEMTELVSSNGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMH 331
+ + L+ + N+ YR A A IP + + LKD+ +H EN +N KM
Sbjct: 785 SALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHE-GNHTLVENLINFEKMR 843
Query: 332 QLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTS 391
++ L + SH+ P ++ L + H + + ++S E S P S
Sbjct: 844 MMARAARMLHHCR--SHNPVP----LSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPAS 897
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 80.9 bits (198), Expect = 4e-15
Identities = 88/382 (23%), Positives = 153/382 (40%), Gaps = 50/382 (13%)
Query: 71 RLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQLGYEKHVSLIDI---------- 120
+L++ R+W+ +F D L++ EEF +K V I
Sbjct: 686 QLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARD 745
Query: 121 ----------SSIPSYDWMRRVTQRKKVSKKGKACLLFD--HLEPIELAEHLTFLEHKSF 168
SS P+ +W +S+ G FD L PIE+A LT LE +
Sbjct: 746 NGPGHNITFQSSPPTVEW--------HISRPGHI-ETFDLLTLHPIEIARQLTLLESDLY 796
Query: 169 RRISFTDYQSYVI--HGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFI 226
R + ++ V N+P L + I ++ W + ++ ++R V+++ I
Sbjct: 797 RAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRII 856
Query: 227 NVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCN 286
+ + +L NFN ++ VV ++ S + RL T + S K E EL S +Y
Sbjct: 857 EILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHEL--SEDHYKK 914
Query: 287 YRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTE---ENKVNIVKMHQLSVTLSELVSL 343
Y + +P G++L +++ P+ + + +N K +++ E+
Sbjct: 915 YLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQY 974
Query: 344 QNASHHLEPNMDL------INLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNK 397
QN + L D+ +N + S++ T D ++ SL +EPRN K P P +
Sbjct: 975 QNQPYCLRVESDIKRFFENLNPMGNSMEKEFT-DYLFNKSLEIEPRNPKPLPRFPKKYSY 1033
Query: 398 P-----VVPLEWALGVMPKPDP 414
P V P G M P P
Sbjct: 1034 PLKSPGVRPSNPRPGTMRHPTP 1055
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,208,407
Number of Sequences: 37866
Number of extensions: 1249702
Number of successful extensions: 5310
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 64
Number of HSP's that attempted gapping in prelim test: 4963
Number of HSP's gapped (non-prelim): 296
length of query: 690
length of database: 18,247,518
effective HSP length: 109
effective length of query: 581
effective length of database: 14,120,124
effective search space: 8203792044
effective search space used: 8203792044
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.