Search of human proteins with 24638433

Search of human proteins with 24638433

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24638433 nicastrin precursor [Homo sapiens]
         (709 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24638433 nicastrin precursor [Homo sapiens]                       1424   0.0  
gi|209862859 DEP domain containing 5 isoform 3 [Homo sapiens]          33   0.91 
gi|7662222 DEP domain containing 5 isoform 1 [Homo sapiens]            33   0.91 
gi|15529990 granzyme H [Homo sapiens]                                  32   2.0  
gi|13376115 adipocyte-specific adhesion molecule [Homo sapiens]        32   2.0  
gi|195972797 leukocyte immunoglobulin-like receptor, subfamily A...    31   4.5  
gi|5803068 leukocyte immunoglobulin-like receptor, subfamily A (...    31   4.5  
gi|189491766 nuclear receptor subfamily 2, group C, member 1 iso...    31   4.5  
gi|189491739 nuclear receptor subfamily 2, group C, member 1 iso...    31   4.5  
gi|73808084 nuclear receptor subfamily 2, group C, member 1 isof...    31   4.5  
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi...    30   5.9  
gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]            30   7.7  
gi|187960059 syndecan 3 [Homo sapiens]                                 30   7.7  
gi|32469495 potassium channel, subfamily K, member 18 [Homo sapi...    30   7.7  
gi|6912568 glucocorticoid modulatory element binding protein 2 [...    30   7.7  

>gi|24638433 nicastrin precursor [Homo sapiens]
          Length = 709

 Score = 1424 bits (3687), Expect = 0.0
 Identities = 709/709 (100%), Positives = 709/709 (100%)

Query: 1   MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI 60
           MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI
Sbjct: 1   MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQI 60

Query: 61  GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG 120
           GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG
Sbjct: 61  GCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAG 120

Query: 121 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI 180
           LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI
Sbjct: 121 LAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPI 180

Query: 181 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF 240
           FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF
Sbjct: 181 FLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTF 240

Query: 241 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA 300
           SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA
Sbjct: 241 SINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVA 300

Query: 301 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD 360
           SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD
Sbjct: 301 SFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVD 360

Query: 361 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ 420
           SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ
Sbjct: 361 SFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQ 420

Query: 421 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV 480
           PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV
Sbjct: 421 PLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFV 480

Query: 481 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ 540
           TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ
Sbjct: 481 TDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQ 540

Query: 541 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY 600
           DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY
Sbjct: 541 DLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY 600

Query: 601 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI 660
           EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI
Sbjct: 601 EYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARI 660

Query: 661 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY 709
           FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
Sbjct: 661 FLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY 709


>gi|209862859 DEP domain containing 5 isoform 3 [Homo sapiens]
          Length = 1594

 Score = 33.1 bits (74), Expect = 0.91
 Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 17/146 (11%)

Query: 337 YIGSSRMVYDMEKGKFPVQLENVDSFVELGQ-VALRTSLELWMHTDPVSQKNESVR--NQ 393
           ++GS+  +  +  G +  Q   ++ F      + L ++   WMHT PV    E+++  +Q
Sbjct: 576 HVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQ 635

Query: 394 VEDLLATLEKSGAGVP----AVIL---------RRPNQSQPLPPSSLQRFLRARNISGVV 440
               +A L+ SG   P    A +L         R  N  QP    S   F     +S V 
Sbjct: 636 TRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELS-VG 694

Query: 441 LADHSGAFHNKYYQSIYDTAENINVS 466
           L  +SGA  N   Q+     ++++ S
Sbjct: 695 LLSNSGAGMNPRTQNKDSLEDSVSTS 720


>gi|7662222 DEP domain containing 5 isoform 1 [Homo sapiens]
          Length = 1572

 Score = 33.1 bits (74), Expect = 0.91
 Identities = 36/146 (24%), Positives = 61/146 (41%), Gaps = 17/146 (11%)

Query: 337 YIGSSRMVYDMEKGKFPVQLENVDSFVELGQ-VALRTSLELWMHTDPVSQKNESVR--NQ 393
           ++GS+  +  +  G +  Q   ++ F      + L ++   WMHT PV    E+++  +Q
Sbjct: 576 HVGSAESMLHVRPGGYTPQRALINPFAPSRMPMKLTSNRRRWMHTFPVGPSGEAIQIHHQ 635

Query: 394 VEDLLATLEKSGAGVP----AVIL---------RRPNQSQPLPPSSLQRFLRARNISGVV 440
               +A L+ SG   P    A +L         R  N  QP    S   F     +S V 
Sbjct: 636 TRQNMAELQGSGQRDPTHSSAELLELAYHEAAGRHSNSRQPGDGMSFLNFSGTEELS-VG 694

Query: 441 LADHSGAFHNKYYQSIYDTAENINVS 466
           L  +SGA  N   Q+     ++++ S
Sbjct: 695 LLSNSGAGMNPRTQNKDSLEDSVSTS 720


>gi|15529990 granzyme H [Homo sapiens]
          Length = 246

 Score = 32.0 bits (71), Expect = 2.0
 Identities = 39/149 (26%), Positives = 59/149 (39%), Gaps = 21/149 (14%)

Query: 6   GGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQ-S 64
           GG  A P SR  +  + F    +    G  + RK ++           L A H   CQ S
Sbjct: 23  GGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFV-----------LTAAH---CQGS 68

Query: 65  SISGDTGVIHVVEKEEDLQWVLTDGP--NPPYMVLLESKHFTRDLMEKLKGRTSRIAGLA 122
           SI+   G  ++ E+E   Q++    P  +P Y      K+F+ D+M     R ++     
Sbjct: 69  SINVTLGAHNIKEQERTQQFIPVKRPIPHPAY----NPKNFSNDIMLLQLERKAKWTTAV 124

Query: 123 VSLTKPSPASGFSPSVQCPNDGFGVYSNS 151
             L  PS  +   P   C   G+G  S S
Sbjct: 125 RPLRLPSSKAQVKPGQLCSVAGWGYVSMS 153


>gi|13376115 adipocyte-specific adhesion molecule [Homo sapiens]
          Length = 373

 Score = 32.0 bits (71), Expect = 2.0
 Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 10/78 (12%)

Query: 81  DLQWVLTDGP-NPPYMVLLESKHFTRDLMEKLKGRTSRI-------AGLAVSLTKPSPAS 132
           D++W+LTD   N   ++   S+H   +L E+ KGR +         A L +   KPS   
Sbjct: 48  DIEWLLTDNEGNQKVVITYSSRHVYNNLTEEQKGRVAFASNFLAGDASLQIEPLKPSDEG 107

Query: 133 GFSPSVQCPNDGFGVYSN 150
            ++  V+  N G  V+S+
Sbjct: 108 RYTCKVK--NSGRYVWSH 123


>gi|195972797 leukocyte immunoglobulin-like receptor, subfamily A
           (with TM domain), member 2 isoform a [Homo sapiens]
          Length = 483

 Score = 30.8 bits (68), Expect = 4.5
 Identities = 36/123 (29%), Positives = 52/123 (42%), Gaps = 12/123 (9%)

Query: 91  NPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPND-GFGVYS 149
           N PY+  L S     DL+E L    S+   L+V    P  A G S ++QC +D G+  + 
Sbjct: 201 NSPYVWSLPS-----DLLELLVPGVSKKPSLSVQ-PGPMVAPGESLTLQCVSDVGYDRFV 254

Query: 150 NSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPT 209
                E    +   W     GL+  +F+          + +    CY  HNLS   SAP+
Sbjct: 255 LYKEGERDFLQRPGWQPQA-GLSQANFTLGPVSPSHGGQYR----CYSAHNLSSEWSAPS 309

Query: 210 FPL 212
            PL
Sbjct: 310 DPL 312


>gi|5803068 leukocyte immunoglobulin-like receptor, subfamily A
           (with TM domain), member 2 isoform b [Homo sapiens]
          Length = 466

 Score = 30.8 bits (68), Expect = 4.5
 Identities = 36/123 (29%), Positives = 52/123 (42%), Gaps = 12/123 (9%)

Query: 91  NPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPND-GFGVYS 149
           N PY+  L S     DL+E L    S+   L+V    P  A G S ++QC +D G+  + 
Sbjct: 201 NSPYVWSLPS-----DLLELLVPGVSKKPSLSVQ-PGPMVAPGESLTLQCVSDVGYDRFV 254

Query: 150 NSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPT 209
                E    +   W     GL+  +F+          + +    CY  HNLS   SAP+
Sbjct: 255 LYKEGERDFLQRPGWQPQA-GLSQANFTLGPVSPSHGGQYR----CYSAHNLSSEWSAPS 309

Query: 210 FPL 212
            PL
Sbjct: 310 DPL 312


>gi|189491766 nuclear receptor subfamily 2, group C, member 1
           isoform c [Homo sapiens]
          Length = 483

 Score = 30.8 bits (68), Expect = 4.5
 Identities = 11/39 (28%), Positives = 21/39 (53%)

Query: 52  RLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGP 90
           + LN      CQSS++G  G +H++  +  + +   +GP
Sbjct: 329 KALNPGESTACQSSVAGMEGSVHLITGDSSINYTEKEGP 367


>gi|189491739 nuclear receptor subfamily 2, group C, member 1
           isoform a [Homo sapiens]
          Length = 603

 Score = 30.8 bits (68), Expect = 4.5
 Identities = 11/39 (28%), Positives = 21/39 (53%)

Query: 52  RLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGP 90
           + LN      CQSS++G  G +H++  +  + +   +GP
Sbjct: 329 KALNPGESTACQSSVAGMEGSVHLITGDSSINYTEKEGP 367


>gi|73808084 nuclear receptor subfamily 2, group C, member 1 isoform
           b [Homo sapiens]
          Length = 467

 Score = 30.8 bits (68), Expect = 4.5
 Identities = 11/39 (28%), Positives = 21/39 (53%)

Query: 52  RLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGP 90
           + LN      CQSS++G  G +H++  +  + +   +GP
Sbjct: 329 KALNPGESTACQSSVAGMEGSVHLITGDSSINYTEKEGP 367


>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
           protein) [Homo sapiens]
          Length = 543

 Score = 30.4 bits (67), Expect = 5.9
 Identities = 18/55 (32%), Positives = 24/55 (43%), Gaps = 2/55 (3%)

Query: 548 DGPLQHYIAVSS--PTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLY 600
           D  L+HY       PTN TY+   A         N  RE C+   +V  EN++ Y
Sbjct: 242 DTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDY 296


>gi|62243658 PI-3-kinase-related kinase SMG-1 [Homo sapiens]
          Length = 3661

 Score = 30.0 bits (66), Expect = 7.7
 Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 6/72 (8%)

Query: 621  VRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIRARIFLIASKELELITLTVGFGIL 680
            +RS+  LA AL+P  +  +W S      TE+  K ++ +   IA   L L TLTV   + 
Sbjct: 1294 LRSSVCLATALNPIEQDQKWQSI-----TENVVKYLK-QTSRIAIGPLRLSTLTVSQSLP 1347

Query: 681  IFSLIVTYCINA 692
            + S +  YC +A
Sbjct: 1348 VLSTLQLYCSSA 1359


>gi|187960059 syndecan 3 [Homo sapiens]
          Length = 442

 Score = 30.0 bits (66), Expect = 7.7
 Identities = 16/32 (50%), Positives = 19/32 (59%)

Query: 2  ATAGGGSGADPGSRGLLRLLSFCVLLAGLCRG 33
          A AG G+ A PG+RGLL      +LLAG   G
Sbjct: 15 AGAGAGAAAGPGARGLLLPPLLLLLLAGRAAG 46


>gi|32469495 potassium channel, subfamily K, member 18 [Homo
           sapiens]
          Length = 384

 Score = 30.0 bits (66), Expect = 7.7
 Identities = 18/59 (30%), Positives = 28/59 (47%), Gaps = 1/59 (1%)

Query: 205 GSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPI 263
           G+ P+ P C+M+LF   HA+    T           +  PE+V   LS Y++ S L  +
Sbjct: 215 GTCPSRPSCSMELFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLS-YSIISNLDEV 272


>gi|6912568 glucocorticoid modulatory element binding protein 2
           [Homo sapiens]
          Length = 530

 Score = 30.0 bits (66), Expect = 7.7
 Identities = 13/36 (36%), Positives = 24/36 (66%), Gaps = 1/36 (2%)

Query: 555 IAVSSPTNTTYV-VQYALANLTGTVVNLTREQCQDP 589
           +++SSPT+  Y+ +  A A++ G+   +T E C+DP
Sbjct: 187 VSLSSPTSAEYIPLTPAAADVNGSPATITIETCEDP 222


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,453,938
Number of Sequences: 37866
Number of extensions: 1209397
Number of successful extensions: 3056
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 3048
Number of HSP's gapped (non-prelim): 17
length of query: 709
length of database: 18,247,518
effective HSP length: 109
effective length of query: 600
effective length of database: 14,120,124
effective search space: 8472074400
effective search space used: 8472074400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.