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Search of human proteins with 11967971
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
sapiens]
(673 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap... 1355 0.0
gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap... 256 4e-68
gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s... 236 4e-62
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7... 226 5e-59
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6... 226 5e-59
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5... 226 5e-59
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3... 226 5e-59
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2... 226 5e-59
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4... 224 3e-58
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s... 210 3e-54
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa... 210 3e-54
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo... 92 2e-18
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s... 91 3e-18
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s... 88 3e-17
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13... 84 4e-16
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s... 83 9e-16
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ... 82 2e-15
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ... 82 2e-15
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s... 81 3e-15
gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sap... 80 6e-15
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform... 77 4e-14
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform... 77 4e-14
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor... 77 5e-14
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor... 77 5e-14
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa... 73 1e-12
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 72 1e-12
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 71 4e-12
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 71 4e-12
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 71 4e-12
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 69 1e-11
>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
sapiens]
Length = 673
Score = 1355 bits (3506), Expect = 0.0
Identities = 673/673 (100%), Positives = 673/673 (100%)
Query: 1 MAGKAAEERGLPKGATPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLAS 60
MAGKAAEERGLPKGATPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLAS
Sbjct: 1 MAGKAAEERGLPKGATPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLAS 60
Query: 61 QVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITG 120
QVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITG
Sbjct: 61 QVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITG 120
Query: 121 RGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFS 180
RGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFS
Sbjct: 121 RGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFS 180
Query: 181 QAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPT 240
QAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPT
Sbjct: 181 QAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPT 240
Query: 241 SGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHM 300
SGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHM
Sbjct: 241 SGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHM 300
Query: 301 VQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFL 360
VQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFL
Sbjct: 301 VQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFL 360
Query: 361 WKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIH 420
WKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIH
Sbjct: 361 WKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISNDFRDLPTLLIH 420
Query: 421 GAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYY 480
GAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYY
Sbjct: 421 GAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYY 480
Query: 481 ELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVF 540
ELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVF
Sbjct: 481 ELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVF 540
Query: 541 CCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCF 600
CCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCF
Sbjct: 541 CCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSLWTVPAWISKVSFLRWCF 600
Query: 601 EGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYV 660
EGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYV
Sbjct: 601 EGLMKIQFSRRTYKMPLGNLTIAVSGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYV 660
Query: 661 SLRFIKQKPSQDW 673
SLRFIKQKPSQDW
Sbjct: 661 SLRFIKQKPSQDW 673
>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
sapiens]
Length = 651
Score = 256 bits (655), Expect = 4e-68
Identities = 180/615 (29%), Positives = 312/615 (50%), Gaps = 30/615 (4%)
Query: 16 TPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPW 75
TP + GLQ S S T + +P++L + +Y V + PW++ + + W
Sbjct: 8 TPGGSMGLQVNRGSQSSLEGAPAT-APEPHSLGILHASYSVSHRVR-PWWD-ITSCRQQW 64
Query: 76 TSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGR-GHGGKIKSGQIWI 134
T ++++S V SGQ++ I+GSSG G+ +LLD ++GR G G G++++
Sbjct: 65 TRQI--------LKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFL-GEVYV 115
Query: 135 NGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAE 194
NG+ + + C ++V Q + LL +LTVRETL + A + + R + K+VE V+AE
Sbjct: 116 NGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRG-NPGSFQKKVEAVMAE 174
Query: 195 LRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKT 254
L L AD +GN + G+S GERRRVSI QLL +P +++ DEPT+GLD TA+ +V
Sbjct: 175 LSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVL 234
Query: 255 LSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRY 314
L LA+ NR+V++++HQPRS++F+LFD + +++ G I+ G M+ +F GYPCP +
Sbjct: 235 LVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEH 294
Query: 315 SNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCV 374
SNP DFY+DLTS+D +S+E+E+ T ++ Q + + + + + K+++ +
Sbjct: 295 SNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSA------ICHKTLKNIERMKHL 348
Query: 375 ESSVTPLDTNCLPSPTK-MPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGF 433
++ P+ +P TK PG + L+RR N R+ ++ + +M + + F
Sbjct: 349 KT--LPM----VPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLF 402
Query: 434 --LYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGP 491
L ++ + D LL+ P+ +L+ ++ RA+ E +DGLY
Sbjct: 403 FVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQ 462
Query: 492 YFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAA 551
A L LP +I+ YW L P + F + + L
Sbjct: 463 MMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLG 522
Query: 552 LLPTFHMASFFSNALYNSFYLAG-GFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSR 610
++ ++ + L + L G GF+ N+ + IS +F ++C E L+ +F
Sbjct: 523 IVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYG 582
Query: 611 RTYKMPLGNLTIAVS 625
+ N+++ +
Sbjct: 583 LNFTCGSSNVSVTTN 597
>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
sapiens]
Length = 655
Score = 236 bits (603), Expect = 4e-62
Identities = 166/585 (28%), Positives = 289/585 (49%), Gaps = 27/585 (4%)
Query: 102 AIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVA-HVRQHNQLLPN 160
AI+G +G G++SLLDV+ R + SG + ING P KC + +V Q + ++
Sbjct: 77 AILGPTGGGKSSLLDVLAARKDPSGL-SGDVLINGAPRPANF--KCNSGYVVQDDVVMGT 133
Query: 161 LTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRR 220
LTVRE L F A +RL T + ++++R+ VI EL L + AD++VG ++RG+SGGER+R
Sbjct: 134 LTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKR 193
Query: 221 VSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLF 280
SIG++L+ +P IL LDEPT+GLDS TA+ ++ L R++K R ++ S+HQPR IF+LF
Sbjct: 194 TSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLF 253
Query: 281 DLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRR----SREQEL 336
D + L+ SG ++ G AQ + YF + GY C Y+NPADF++D+ + D +RE++
Sbjct: 254 DSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDF 313
Query: 337 ATRE--KAQSLAALFLEKVRDL--DDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKM 392
E + +EK+ ++ + +K +L + + +
Sbjct: 314 KATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQ---LSGGEKKKKITVFKEISYT 370
Query: 393 PGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALL 452
Q + +R N + + ++ + IG +YFG + + A +L
Sbjct: 371 TSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVL 430
Query: 453 FMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGE-LPEHCAYIIIY 511
F + F+ + + E+ + +E G Y YF K+L + LP II+
Sbjct: 431 FFLTTNQCFSSV-SAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIF 489
Query: 512 GMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFY 571
Y++ L+P F + + +V + MALA AA +A+ +
Sbjct: 490 TCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMM 549
Query: 572 LAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLT-------IAV 624
+ G ++NL+++ + +W+ S R+ F L +F + + P N T
Sbjct: 550 IFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNF-CPGLNATGNNPCNYATC 608
Query: 625 SGDKILSVMELDSYP--LYAIYLIVIGLSGGFMVLYYVSLRFIKQ 667
+G++ L +D P L+ ++ + + F+ + Y+ L F+K+
Sbjct: 609 TGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKK 653
>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
[Homo sapiens]
Length = 663
Score = 226 bits (576), Expect = 5e-59
Identities = 160/624 (25%), Positives = 290/624 (46%), Gaps = 52/624 (8%)
Query: 47 LEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGS 106
+E RDL+Y V + PW+ + + ++ +S K SG+++AI+G
Sbjct: 74 IEFRDLSYSVP---EGPWWRKKGYKTL--------------LKGISGKFNSGELVAIMGP 116
Query: 107 SGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRET 166
SG G+++L++++ G G G + ING P + RK ++ Q + LLP+LTV+E
Sbjct: 117 SGAGKSTLMNILAGYRETGM--KGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEA 174
Query: 167 LAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQ 226
+ A ++L R + V++++ L L CA+TR G+ LSGG+R+R++I ++
Sbjct: 175 MMVSAHLKLQE--KDEGRREMVKEILTALGLLSCANTRTGS-----LSGGQRKRLAIALE 227
Query: 227 LLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLM 286
L+ NP ++ DEPTSGLDS + +V + LA+G R ++ ++HQP + +F LFD + ++
Sbjct: 228 LVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVL 287
Query: 287 TSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTS---IDRRSREQELATREKAQ 343
+ G +Y G ++V Y +G CP Y NPADF +++ S D+ SR
Sbjct: 288 SQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCD 347
Query: 344 SLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLI 403
S L +++ FLW + +ED+ +CL QF L
Sbjct: 348 SDHKRDLGGDAEVNPFLWH---RPSEEDSSSMEGCHSFSASCL----------TQFCILF 394
Query: 404 RRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNV 463
+R + RD + + + IG LY G G+ + + LF + F
Sbjct: 395 KRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAA 454
Query: 464 ILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRP 523
++ + E + E + Y+ Y+ AK + ++P + + Y YW+ +
Sbjct: 455 LMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPS 514
Query: 524 GLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSL 583
F+L L + + + L A + +A+F L GF ++ ++
Sbjct: 515 DAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTI 574
Query: 584 WTVPAWISKVSFLRWCFEGLMKIQF--SRRTYKMPLGNLTIAVSGDKILSVMELDSYPLY 641
T W+S +S++R+ FEG++ + R + + IL +++++ LY
Sbjct: 575 PTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLY 634
Query: 642 AIYLIVIGLSGGFMVLYYVSLRFI 665
+ IV+G ++++SLR I
Sbjct: 635 -LDFIVLG-------IFFISLRLI 650
>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
[Homo sapiens]
Length = 644
Score = 226 bits (576), Expect = 5e-59
Identities = 160/624 (25%), Positives = 290/624 (46%), Gaps = 52/624 (8%)
Query: 47 LEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGS 106
+E RDL+Y V + PW+ + + ++ +S K SG+++AI+G
Sbjct: 55 IEFRDLSYSVP---EGPWWRKKGYKTL--------------LKGISGKFNSGELVAIMGP 97
Query: 107 SGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRET 166
SG G+++L++++ G G G + ING P + RK ++ Q + LLP+LTV+E
Sbjct: 98 SGAGKSTLMNILAGYRETGM--KGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEA 155
Query: 167 LAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQ 226
+ A ++L R + V++++ L L CA+TR G+ LSGG+R+R++I ++
Sbjct: 156 MMVSAHLKLQE--KDEGRREMVKEILTALGLLSCANTRTGS-----LSGGQRKRLAIALE 208
Query: 227 LLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLM 286
L+ NP ++ DEPTSGLDS + +V + LA+G R ++ ++HQP + +F LFD + ++
Sbjct: 209 LVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVL 268
Query: 287 TSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTS---IDRRSREQELATREKAQ 343
+ G +Y G ++V Y +G CP Y NPADF +++ S D+ SR
Sbjct: 269 SQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCD 328
Query: 344 SLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLI 403
S L +++ FLW + +ED+ +CL QF L
Sbjct: 329 SDHKRDLGGDAEVNPFLWH---RPSEEDSSSMEGCHSFSASCL----------TQFCILF 375
Query: 404 RRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNV 463
+R + RD + + + IG LY G G+ + + LF + F
Sbjct: 376 KRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAA 435
Query: 464 ILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRP 523
++ + E + E + Y+ Y+ AK + ++P + + Y YW+ +
Sbjct: 436 LMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPS 495
Query: 524 GLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSL 583
F+L L + + + L A + +A+F L GF ++ ++
Sbjct: 496 DAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTI 555
Query: 584 WTVPAWISKVSFLRWCFEGLMKIQF--SRRTYKMPLGNLTIAVSGDKILSVMELDSYPLY 641
T W+S +S++R+ FEG++ + R + + IL +++++ LY
Sbjct: 556 PTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLY 615
Query: 642 AIYLIVIGLSGGFMVLYYVSLRFI 665
+ IV+G ++++SLR I
Sbjct: 616 -LDFIVLG-------IFFISLRLI 631
>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
[Homo sapiens]
Length = 668
Score = 226 bits (576), Expect = 5e-59
Identities = 160/624 (25%), Positives = 290/624 (46%), Gaps = 52/624 (8%)
Query: 47 LEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGS 106
+E RDL+Y V + PW+ + + ++ +S K SG+++AI+G
Sbjct: 79 IEFRDLSYSVP---EGPWWRKKGYKTL--------------LKGISGKFNSGELVAIMGP 121
Query: 107 SGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRET 166
SG G+++L++++ G G G + ING P + RK ++ Q + LLP+LTV+E
Sbjct: 122 SGAGKSTLMNILAGYRETGM--KGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEA 179
Query: 167 LAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQ 226
+ A ++L R + V++++ L L CA+TR G+ LSGG+R+R++I ++
Sbjct: 180 MMVSAHLKLQE--KDEGRREMVKEILTALGLLSCANTRTGS-----LSGGQRKRLAIALE 232
Query: 227 LLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLM 286
L+ NP ++ DEPTSGLDS + +V + LA+G R ++ ++HQP + +F LFD + ++
Sbjct: 233 LVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVL 292
Query: 287 TSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTS---IDRRSREQELATREKAQ 343
+ G +Y G ++V Y +G CP Y NPADF +++ S D+ SR
Sbjct: 293 SQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCD 352
Query: 344 SLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLI 403
S L +++ FLW + +ED+ +CL QF L
Sbjct: 353 SDHKRDLGGDAEVNPFLWH---RPSEEDSSSMEGCHSFSASCL----------TQFCILF 399
Query: 404 RRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNV 463
+R + RD + + + IG LY G G+ + + LF + F
Sbjct: 400 KRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAA 459
Query: 464 ILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRP 523
++ + E + E + Y+ Y+ AK + ++P + + Y YW+ +
Sbjct: 460 LMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPS 519
Query: 524 GLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSL 583
F+L L + + + L A + +A+F L GF ++ ++
Sbjct: 520 DAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTI 579
Query: 584 WTVPAWISKVSFLRWCFEGLMKIQF--SRRTYKMPLGNLTIAVSGDKILSVMELDSYPLY 641
T W+S +S++R+ FEG++ + R + + IL +++++ LY
Sbjct: 580 PTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLY 639
Query: 642 AIYLIVIGLSGGFMVLYYVSLRFI 665
+ IV+G ++++SLR I
Sbjct: 640 -LDFIVLG-------IFFISLRLI 655
>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
[Homo sapiens]
Length = 677
Score = 226 bits (576), Expect = 5e-59
Identities = 160/624 (25%), Positives = 290/624 (46%), Gaps = 52/624 (8%)
Query: 47 LEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGS 106
+E RDL+Y V + PW+ + + ++ +S K SG+++AI+G
Sbjct: 88 IEFRDLSYSVP---EGPWWRKKGYKTL--------------LKGISGKFNSGELVAIMGP 130
Query: 107 SGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRET 166
SG G+++L++++ G G G + ING P + RK ++ Q + LLP+LTV+E
Sbjct: 131 SGAGKSTLMNILAGYRETGM--KGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEA 188
Query: 167 LAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQ 226
+ A ++L R + V++++ L L CA+TR G+ LSGG+R+R++I ++
Sbjct: 189 MMVSAHLKLQE--KDEGRREMVKEILTALGLLSCANTRTGS-----LSGGQRKRLAIALE 241
Query: 227 LLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLM 286
L+ NP ++ DEPTSGLDS + +V + LA+G R ++ ++HQP + +F LFD + ++
Sbjct: 242 LVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVL 301
Query: 287 TSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTS---IDRRSREQELATREKAQ 343
+ G +Y G ++V Y +G CP Y NPADF +++ S D+ SR
Sbjct: 302 SQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCD 361
Query: 344 SLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLI 403
S L +++ FLW + +ED+ +CL QF L
Sbjct: 362 SDHKRDLGGDAEVNPFLWH---RPSEEDSSSMEGCHSFSASCL----------TQFCILF 408
Query: 404 RRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNV 463
+R + RD + + + IG LY G G+ + + LF + F
Sbjct: 409 KRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAA 468
Query: 464 ILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRP 523
++ + E + E + Y+ Y+ AK + ++P + + Y YW+ +
Sbjct: 469 LMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPS 528
Query: 524 GLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSL 583
F+L L + + + L A + +A+F L GF ++ ++
Sbjct: 529 DAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTI 588
Query: 584 WTVPAWISKVSFLRWCFEGLMKIQF--SRRTYKMPLGNLTIAVSGDKILSVMELDSYPLY 641
T W+S +S++R+ FEG++ + R + + IL +++++ LY
Sbjct: 589 PTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLY 648
Query: 642 AIYLIVIGLSGGFMVLYYVSLRFI 665
+ IV+G ++++SLR I
Sbjct: 649 -LDFIVLG-------IFFISLRLI 664
>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
[Homo sapiens]
Length = 666
Score = 226 bits (576), Expect = 5e-59
Identities = 160/624 (25%), Positives = 290/624 (46%), Gaps = 52/624 (8%)
Query: 47 LEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGS 106
+E RDL+Y V + PW+ + + ++ +S K SG+++AI+G
Sbjct: 77 IEFRDLSYSVP---EGPWWRKKGYKTL--------------LKGISGKFNSGELVAIMGP 119
Query: 107 SGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRET 166
SG G+++L++++ G G G + ING P + RK ++ Q + LLP+LTV+E
Sbjct: 120 SGAGKSTLMNILAGYRETGM--KGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEA 177
Query: 167 LAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQ 226
+ A ++L R + V++++ L L CA+TR G+ LSGG+R+R++I ++
Sbjct: 178 MMVSAHLKLQE--KDEGRREMVKEILTALGLLSCANTRTGS-----LSGGQRKRLAIALE 230
Query: 227 LLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLM 286
L+ NP ++ DEPTSGLDS + +V + LA+G R ++ ++HQP + +F LFD + ++
Sbjct: 231 LVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVL 290
Query: 287 TSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTS---IDRRSREQELATREKAQ 343
+ G +Y G ++V Y +G CP Y NPADF +++ S D+ SR
Sbjct: 291 SQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCD 350
Query: 344 SLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLI 403
S L +++ FLW + +ED+ +CL QF L
Sbjct: 351 SDHKRDLGGDAEVNPFLWH---RPSEEDSSSMEGCHSFSASCL----------TQFCILF 397
Query: 404 RRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFMIGALIPFNV 463
+R + RD + + + IG LY G G+ + + LF + F
Sbjct: 398 KRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAA 457
Query: 464 ILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMPTYWLANLRP 523
++ + E + E + Y+ Y+ AK + ++P + + Y YW+ +
Sbjct: 458 LMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPS 517
Query: 524 GLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMINLSSL 583
F+L L + + + L A + +A+F L GF ++ ++
Sbjct: 518 DAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTI 577
Query: 584 WTVPAWISKVSFLRWCFEGLMKIQF--SRRTYKMPLGNLTIAVSGDKILSVMELDSYPLY 641
T W+S +S++R+ FEG++ + R + + IL +++++ LY
Sbjct: 578 PTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLY 637
Query: 642 AIYLIVIGLSGGFMVLYYVSLRFI 665
+ IV+G ++++SLR I
Sbjct: 638 -LDFIVLG-------IFFISLRLI 653
>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
[Homo sapiens]
Length = 678
Score = 224 bits (570), Expect = 3e-58
Identities = 161/633 (25%), Positives = 291/633 (45%), Gaps = 58/633 (9%)
Query: 47 LEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGIQNLSFKVRSGQMLAIIGS 106
+E RDL+Y V + PW+ + + ++ +S K SG+++AI+G
Sbjct: 77 IEFRDLSYSVP---EGPWWRKKGYKTL--------------LKGISGKFNSGELVAIMGP 119
Query: 107 SGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRET 166
SG G+++L++++ G G G + ING P + RK ++ Q + LLP+LTV+E
Sbjct: 120 SGAGKSTLMNILAGYRETGM--KGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEA 177
Query: 167 LAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQ 226
+ A ++L R + V++++ L L CA+TR G+ LSGG+R+R++I ++
Sbjct: 178 MMVSAHLKLQE--KDEGRREMVKEILTALGLLSCANTRTGS-----LSGGQRKRLAIALE 230
Query: 227 LLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQPRSDIFRLFDLVLLM 286
L+ NP ++ DEPTSGLDS + +V + LA+G R ++ ++HQP + +F LFD + ++
Sbjct: 231 LVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVL 290
Query: 287 TSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTS---IDRRSREQELATREKAQ 343
+ G +Y G ++V Y +G CP Y NPADF +++ S D+ SR
Sbjct: 291 SQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCD 350
Query: 344 SLAALFLEKVRDLDDFLWKAET---------KDLDEDTCVESSVTPLDTNCLPSPTKMPG 394
S L +++ FLW + K L +D+ +CL
Sbjct: 351 SDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCL-------- 402
Query: 395 AVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDTAALLFM 454
QF L +R + RD + + + IG LY G G+ + + LF
Sbjct: 403 --TQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFF 460
Query: 455 IGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYIIIYGMP 514
+ F ++ + E + E + Y+ Y+ AK + ++P + + Y
Sbjct: 461 SMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSI 520
Query: 515 TYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAG 574
YW+ + F+L L + + + L A + +A+F L
Sbjct: 521 VYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFS 580
Query: 575 GFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQF--SRRTYKMPLGNLTIAVSGDKILSV 632
GF ++ ++ T W+S +S++R+ FEG++ + R + + IL
Sbjct: 581 GFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRE 640
Query: 633 MELDSYPLYAIYLIVIGLSGGFMVLYYVSLRFI 665
+++++ LY + IV+G ++++SLR I
Sbjct: 641 LDVENAKLY-LDFIVLG-------IFFISLRLI 665
>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 210 bits (535), Expect = 3e-54
Identities = 149/582 (25%), Positives = 262/582 (45%), Gaps = 37/582 (6%)
Query: 91 LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAH 150
LS K +++ I+G SG G+++ ++++ G G GQI +NG+P + RK +
Sbjct: 88 LSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGM--KGQILVNGRPRELRTFRKMSCY 145
Query: 151 VRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYV 210
+ Q + LLP+LTV E + A ++L Q + + V +++ L L C+ TR
Sbjct: 146 IMQDDMLLPHLTVLEAMMVSANLKLSE--KQEVKKELVTEILTALGLMSCSHTRTAL--- 200
Query: 211 RGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLH 270
LSGG+R+R++I ++L+ NP ++ DEPTSGLDS + +V + LA+G R ++ ++H
Sbjct: 201 --LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
Query: 271 QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRR 330
QP + +F +FD + +++ G I+ G +++ Y +G CP Y NPADF +++ S +
Sbjct: 259 QPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYG 318
Query: 331 SREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPL--DTNCLPS 388
L R L A+ AE K E V + P + + + S
Sbjct: 319 DLNPML-FRAVQNGLCAM--------------AEKKSSPEKNEVPAPCPPCPPEVDPIES 363
Query: 389 PTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDT 448
T + QF L +R + RD + ++ + IG LY G +
Sbjct: 364 HTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNN 423
Query: 449 AALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYI 508
LF + F ++ + E A+ E + Y+ Y+ AK + ++P
Sbjct: 424 TGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCP 483
Query: 509 IIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYN 568
++Y YW+ FLL L + + L A + +A+F
Sbjct: 484 VVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAI 543
Query: 569 SFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAV---- 624
L GF ++ ++ T W S +S++R+ FEG++ Y M G+LT
Sbjct: 544 PVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVI-----LTIYGMERGDLTCLEERCP 598
Query: 625 --SGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYVSLRF 664
IL ++++ LY +L++ +L Y+ LR+
Sbjct: 599 FREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRY 640
>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
sapiens]
Length = 646
Score = 210 bits (535), Expect = 3e-54
Identities = 149/582 (25%), Positives = 262/582 (45%), Gaps = 37/582 (6%)
Query: 91 LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAH 150
LS K +++ I+G SG G+++ ++++ G G GQI +NG+P + RK +
Sbjct: 88 LSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGM--KGQILVNGRPRELRTFRKMSCY 145
Query: 151 VRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYV 210
+ Q + LLP+LTV E + A ++L Q + + V +++ L L C+ TR
Sbjct: 146 IMQDDMLLPHLTVLEAMMVSANLKLSE--KQEVKKELVTEILTALGLMSCSHTRTAL--- 200
Query: 211 RGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLH 270
LSGG+R+R++I ++L+ NP ++ DEPTSGLDS + +V + LA+G R ++ ++H
Sbjct: 201 --LSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH 258
Query: 271 QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRR 330
QP + +F +FD + +++ G I+ G +++ Y +G CP Y NPADF +++ S +
Sbjct: 259 QPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYG 318
Query: 331 SREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPL--DTNCLPS 388
L R L A+ AE K E V + P + + + S
Sbjct: 319 DLNPML-FRAVQNGLCAM--------------AEKKSSPEKNEVPAPCPPCPPEVDPIES 363
Query: 389 PTKMPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSIQLSFMDT 448
T + QF L +R + RD + ++ + IG LY G +
Sbjct: 364 HTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNN 423
Query: 449 AALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPEHCAYI 508
LF + F ++ + E A+ E + Y+ Y+ AK + ++P
Sbjct: 424 TGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCP 483
Query: 509 IIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYN 568
++Y YW+ FLL L + + L A + +A+F
Sbjct: 484 VVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAI 543
Query: 569 SFYLAGGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLGNLTIAV---- 624
L GF ++ ++ T W S +S++R+ FEG++ Y M G+LT
Sbjct: 544 PVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVI-----LTIYGMERGDLTCLEERCP 598
Query: 625 --SGDKILSVMELDSYPLYAIYLIVIGLSGGFMVLYYVSLRF 664
IL ++++ LY +L++ +L Y+ LR+
Sbjct: 599 FREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRY 640
>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
sapiens]
Length = 1543
Score = 92.0 bits (227), Expect = 2e-18
Identities = 76/277 (27%), Positives = 144/277 (51%), Gaps = 21/277 (7%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRG----HGGKIKSGQIWINGQPSSPQL 143
+Q + F + GQ+ AI+G +G G+++LL++++G I + Q+ + + +
Sbjct: 410 LQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQL---SEITDMEE 466
Query: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADT 203
+RK + Q N LTVRE L A+++ + ++ V+ +I EL ++ D
Sbjct: 467 IRKNIGFCPQFNFQFDFLTVRENLRVFAKIK---GIQPKEVEQEVKRIIMELDMQSIQD- 522
Query: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263
+ + LSGG++R++++G+ +L +P +L+LDEPT+GLD F+ H V +L + K +R
Sbjct: 523 ----IIAKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHR-VWSLLKEHKVDR 577
Query: 264 LVLISLH-QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYV 322
L+L S +DI L D + +++G G++ + + + IGY + N
Sbjct: 578 LILFSTQFMDEADI--LADRKVFLSNGKLKCAGSSLFLKRKW-GIGYHLSLHRNEMCDTE 634
Query: 323 DLTS-IDRRSREQELATREKAQSLAALFLEKVRDLDD 358
+TS I + + +L T + + + +L LEK D
Sbjct: 635 KITSLIKQHIPDAKLTTESEEKLVYSLPLEKTNKFPD 671
Score = 76.3 bits (186), Expect = 9e-14
Identities = 58/225 (25%), Positives = 113/225 (50%), Gaps = 17/225 (7%)
Query: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLV 144
++ I+N+SF V+ G++L ++G +G G+++ + +ITG K +G + + G +S +
Sbjct: 1219 KIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCT---KPTAGVVVLQGSRASVRQQ 1275
Query: 145 R----KCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQC 200
K + + Q N L P LT++E L A ++ + + ++ L+L++
Sbjct: 1276 HDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVK---GLGKEDAALSISRLVEALKLQEQ 1332
Query: 201 ADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAK 260
V + LS G +R++ + +L NP +++LDEP +G+D + + L K
Sbjct: 1333 LKAPV-----KTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVK 1387
Query: 261 G-NRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
R L++ H S+ + D + +M SGT +G+ QH+ F
Sbjct: 1388 NKERGTLLTTHY-MSEAEAVCDRMAMMVSGTLRCIGSIQHLKNKF 1431
>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
sapiens]
Length = 1704
Score = 90.9 bits (224), Expect = 3e-18
Identities = 72/230 (31%), Positives = 114/230 (49%), Gaps = 16/230 (6%)
Query: 82 NSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSP 141
N +++L+ + GQ+ ++G +G G+ + L ++TG SG+ +I+G S
Sbjct: 543 NKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPP---TSGRAYISGYEISQ 599
Query: 142 QLV--RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQ 199
+V RK + QH+ L NLTV E L F AQ++ R K E+V L +
Sbjct: 600 DMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLK------GLSRQKCPEEVKQMLHIIG 653
Query: 200 CADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLA 259
D N R LSGG RR++SIG+ L+ +LILDEPTSG+D+ + + L R
Sbjct: 654 LEDK--WNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQK 711
Query: 260 KGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGY 309
+VL + +D+ L D + +M G G++ + Q + A GY
Sbjct: 712 SDRTIVLTTHFMDEADL--LGDRIAIMAKGELQCCGSSLFLKQKYGA-GY 758
Score = 87.0 bits (214), Expect = 5e-17
Identities = 62/222 (27%), Positives = 109/222 (49%), Gaps = 16/222 (7%)
Query: 86 LGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL-- 143
L + LS V+ G+ ++G +G G+ + ++TG + SG ++ G S +
Sbjct: 1397 LAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEE---SLTSGDAFVGGHRISSDVGK 1453
Query: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMR-LPRTFSQAQRDKRVEDVIAELRLRQCAD 202
VR+ + + Q + LL ++T RE L A++R +P A VE+ + L L A
Sbjct: 1454 VRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGAC----VENTLRGLLLEPHA- 1508
Query: 203 TRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGN 262
N VR SGG +R++S G+ L+ P ++ LDEP++G+D L T++R +
Sbjct: 1509 ----NKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESG 1564
Query: 263 RLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
+ ++I+ H + L + +M G LG+ QH+ F
Sbjct: 1565 KAIIITSHS-MEECEALCTRLAIMVQGQFKCLGSPQHLKSKF 1605
>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
sapiens]
Length = 1617
Score = 87.8 bits (216), Expect = 3e-17
Identities = 79/300 (26%), Positives = 144/300 (48%), Gaps = 26/300 (8%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSP----QL 143
++ L F + GQ+ AI+G SG G++SLL+++ G + G + I + S +
Sbjct: 497 LKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTE---GSVTIYNKNLSEMQDLEE 553
Query: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADT 203
+RK Q N LTV+E L+ A+++ + ++ V+ ++ EL ++ D
Sbjct: 554 IRKITGVCPQFNVQFDILTVKENLSLFAKIK---GIHLKEVEQEVQRILLELDMQNIQDN 610
Query: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263
+ LS G++R+++ G+ +L +P IL+LDEPT+GLD F + + V +L R + +
Sbjct: 611 -----LAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPF-SRDQVWSLLRERRADH 664
Query: 264 LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVD 323
++L S Q + L D ++M++G G++ + + + +GY + N
Sbjct: 665 VILFST-QSMDEADILADRKVIMSNGRLKCAGSSMFLKRRW-GLGYHLSLHRNEICNPEQ 722
Query: 324 LTS-IDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLD 382
+TS I + +L T K + + L LE+ D D D C + VT D
Sbjct: 723 ITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLF-------SDLDKCSDQGVTGYD 775
Score = 73.6 bits (179), Expect = 6e-13
Identities = 59/217 (27%), Positives = 113/217 (52%), Gaps = 17/217 (7%)
Query: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLV 144
++ +N+SF V+ G++L ++G +G G++S + +I+G K +G++ + G S V
Sbjct: 1300 KIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGIT---KPTAGEVELKGCSS----V 1352
Query: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR 204
+ + Q N L P LT+RE L A ++ R +A + +++ +L +
Sbjct: 1353 LGHLGYCPQENVLWPMLTLREHLEVYAAVKGLR---KADARLAIARLVSAFKLHEQL--- 1406
Query: 205 VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKG-NR 263
N+ V+ L+ G R++ + LL N +L+LDEP++G+D + + + + K R
Sbjct: 1407 --NVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTER 1464
Query: 264 LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHM 300
VL++ H ++ L D V +M SG +G+ QH+
Sbjct: 1465 GVLLTTHN-LAEAEALCDRVAIMVSGRLRCIGSIQHL 1500
>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
[Homo sapiens]
Length = 5058
Score = 84.0 bits (206), Expect = 4e-16
Identities = 59/204 (28%), Positives = 109/204 (53%), Gaps = 13/204 (6%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL--VR 145
+Q+LS Q+ A++G++G G+ +++ ++TG SG I ING+ L VR
Sbjct: 3858 VQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPP---TSGTIIINGKNLQTDLSRVR 3914
Query: 146 KCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRV 205
+ Q + LL NLTVRE L A ++ P+ +++ + ++V + ++ L T+
Sbjct: 3915 MELGVCPQQDILLDNLTVREHLLLFASIKAPQ-WTKKELHQQVNQTLQDVDL-----TQH 3968
Query: 206 GNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLV 265
+ R LSGG +R++S+G+ + ++LDEPTSG+D + H+L L + +G ++
Sbjct: 3969 QHKQTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKYREGRTII 4028
Query: 266 LISLHQPRSDIFRLFDLVLLMTSG 289
+ H ++ L D V ++ G
Sbjct: 4029 FTTHHLDEAE--ALSDRVAVLQHG 4050
Score = 59.3 bits (142), Expect = 1e-08
Identities = 55/226 (24%), Positives = 101/226 (44%), Gaps = 20/226 (8%)
Query: 86 LGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQP------S 139
+ +Q++S + G+ ++G +G G+++ ++ G + SG I S
Sbjct: 4735 IAVQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEV---SLTSGHAIIRTPMGDAVDLS 4791
Query: 140 SPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMR-LPRTFSQAQRDKRVEDVIAELRLR 198
S + + Q + L LT E L + +R +PR + D+I L L
Sbjct: 4792 SAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSLRGIPRQCIP----EVAGDLIRRLHLE 4847
Query: 199 QCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRL 258
AD V SGG +R++S + L+ P IL+LDEP+SG+D + L +T+ +
Sbjct: 4848 AHADKPVATY-----SGGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTIMKE 4902
Query: 259 AKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
+ +++ H + L + +M +G+ LG+ QH+ F
Sbjct: 4903 VREGCAAVLTSHS-MEECEALCTRLAIMVNGSFKCLGSPQHIKNRF 4947
>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
sapiens]
Length = 1624
Score = 82.8 bits (203), Expect = 9e-16
Identities = 75/285 (26%), Positives = 133/285 (46%), Gaps = 32/285 (11%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL---- 143
++ + F + GQ+ A++G SG G+ +LL++++G SG + + S
Sbjct: 500 LKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVP---TSGSVTVYNHTLSRMADIEN 556
Query: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMR--LPRTFSQAQRDKRVEDVIAELRLRQCA 201
+ K Q N LTV+E L A+++ LP + +K V+ V+ EL +
Sbjct: 557 ISKFTGFCPQSNVQFGFLTVKENLRLFAKIKGILPH-----EVEKEVQRVVQELEMENIQ 611
Query: 202 DTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKG 261
D N LSGG+ R+++ G+ +L +P +L+LDEPT+GLD + H + L K
Sbjct: 612 DILAQN-----LSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE-GKS 665
Query: 262 NRLVLISLH-QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADF 320
+R++L S +DI L D + +++G G++ + + + IGY + N
Sbjct: 666 DRVILFSTQFIDEADI--LADRKVFISNGKLKCAGSSLFLKKKW-GIGYHLSLHLNERCD 722
Query: 321 YVDLTSIDRRSREQELATREKAQSLAAL--------FLEKVRDLD 357
+TS+ ++ T + + L + F E RDLD
Sbjct: 723 PESITSLVKQHISDAKLTAQSEEKLVYILPLERTNKFPELYRDLD 767
Score = 74.3 bits (181), Expect = 3e-13
Identities = 72/302 (23%), Positives = 143/302 (47%), Gaps = 25/302 (8%)
Query: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLV 144
++ +N+SF V+ G+++ ++G +G G+++ + +ITG K +GQ+ + G L
Sbjct: 1306 KIATRNVSFCVKKGEVIGLLGHNGAGKSTTIKMITG---DTKPTAGQVILKGSGGGEPL- 1361
Query: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR 204
+ + Q N L PNLTVR+ L A ++ R R+ D L+L+
Sbjct: 1362 -GFLGYCPQENALWPNLTVRQHLEVYAAVKGLRKGDAMIAITRLVDA---LKLQDQLKAP 1417
Query: 205 VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTL-SRLAKGNR 263
V + LS G +R++ + +L NP +++LDEP++G+D + + + + R
Sbjct: 1418 V-----KTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTER 1472
Query: 264 LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF---TAIGYPCPRYSNPADF 320
L++ H ++ + D V +M SG +G+ QH+ F + +
Sbjct: 1473 GALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKLKNLAQMEPL 1531
Query: 321 YVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAE----TKDLDEDTCVES 376
+ ++ + ++ +QE R + + L +E VR L +K E + DL+E + +S
Sbjct: 1532 HAEILRLFPQAAQQE---RFSSLMVYKLPVEDVRPLSQAFFKLEIVKQSFDLEEYSLSQS 1588
Query: 377 SV 378
++
Sbjct: 1589 TL 1590
>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/277 (27%), Positives = 137/277 (49%), Gaps = 22/277 (7%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQ----L 143
++NLSF + GQ+ A++G SG G+++L++++ G G I G S
Sbjct: 497 LRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPS---DGFASIYGHRVSEIDEMFE 553
Query: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADT 203
RK + Q + LTV E L+ +A ++ + Q V+ V+ +L ++ D
Sbjct: 554 ARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE---VQKVLLDLDMQTIKDN 610
Query: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263
+ + LSGG++R++S+G+ +L NP IL+LDEPT+G+D + H +V L + K NR
Sbjct: 611 QA-----KKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRH-IVWNLLKYRKANR 664
Query: 264 LVLISLH-QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYV 322
+ + S H +DI L D +++ G +G++ + + IGY Y +
Sbjct: 665 VTVFSTHFMDEADI--LADRKAVISQGMLKCVGSSMFLKSKW-GIGYRLSMYIDKYCATE 721
Query: 323 DLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDF 359
L+S+ ++ ++ Q L ++ +D+D F
Sbjct: 722 SLSSLVKQHIPGATLLQQNDQQL--VYSLPFKDMDKF 756
Score = 70.5 bits (171), Expect = 5e-12
Identities = 49/217 (22%), Positives = 103/217 (47%), Gaps = 14/217 (6%)
Query: 91 LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWI---NGQPSSPQLVRKC 147
+SF V+ G++L ++G +G G++++++++ G + SGQ+++ + + S KC
Sbjct: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVG---DIEPTSGQVFLGDYSSETSEDDDSLKC 1375
Query: 148 VAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGN 207
+ + Q N L P+ T++E ++ S + + + + L L++ V
Sbjct: 1376 MGYCPQINPLWPDTTLQEHFEIYGAVK---GMSASDMKEVISRITHALDLKEHLQKTV-- 1430
Query: 208 MYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLI 267
+ L G +R++ + +L NP I +LDEP++G+D ++ + + K + I
Sbjct: 1431 ---KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
Query: 268 SLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
+ + D V +M SG +G QH+ F
Sbjct: 1488 LTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKF 1524
>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
sapiens]
Length = 1642
Score = 81.6 bits (200), Expect = 2e-15
Identities = 75/277 (27%), Positives = 137/277 (49%), Gaps = 22/277 (7%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQ----L 143
++NLSF + GQ+ A++G SG G+++L++++ G G I G S
Sbjct: 497 LRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPS---DGFASIYGHRVSEIDEMFE 553
Query: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADT 203
RK + Q + LTV E L+ +A ++ + Q V+ V+ +L ++ D
Sbjct: 554 ARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQE---VQKVLLDLDMQTIKDN 610
Query: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263
+ + LSGG++R++S+G+ +L NP IL+LDEPT+G+D + H +V L + K NR
Sbjct: 611 QA-----KKLSGGQKRKLSLGIAVLGNPKILLLDEPTAGMDPCSRH-IVWNLLKYRKANR 664
Query: 264 LVLISLH-QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYV 322
+ + S H +DI L D +++ G +G++ + + IGY Y +
Sbjct: 665 VTVFSTHFMDEADI--LADRKAVISQGMLKCVGSSMFLKSKW-GIGYRLSMYIDKYCATE 721
Query: 323 DLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDF 359
L+S+ ++ ++ Q L ++ +D+D F
Sbjct: 722 SLSSLVKQHIPGATLLQQNDQQL--VYSLPFKDMDKF 756
Score = 70.5 bits (171), Expect = 5e-12
Identities = 49/217 (22%), Positives = 103/217 (47%), Gaps = 14/217 (6%)
Query: 91 LSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWI---NGQPSSPQLVRKC 147
+SF V+ G++L ++G +G G++++++++ G + SGQ+++ + + S KC
Sbjct: 1319 ISFCVKKGEILGLLGPNGAGKSTIINILVG---DIEPTSGQVFLGDYSSETSEDDDSLKC 1375
Query: 148 VAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGN 207
+ + Q N L P+ T++E ++ S + + + + L L++ V
Sbjct: 1376 MGYCPQINPLWPDTTLQEHFEIYGAVK---GMSASDMKEVISRITHALDLKEHLQKTV-- 1430
Query: 208 MYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLI 267
+ L G +R++ + +L NP I +LDEP++G+D ++ + + K + I
Sbjct: 1431 ---KKLPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAAI 1487
Query: 268 SLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
+ + D V +M SG +G QH+ F
Sbjct: 1488 LTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKF 1524
>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
sapiens]
Length = 2273
Score = 81.3 bits (199), Expect = 3e-15
Identities = 57/215 (26%), Positives = 107/215 (49%), Gaps = 21/215 (9%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL--VR 145
+ L+ Q+ A +G +G G+ + L ++TG SG + + G+ L VR
Sbjct: 946 VDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPP---TSGTVLVGGRDIETSLDAVR 1002
Query: 146 KCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRV 205
+ + QHN L +LTV E + F AQ++ ++Q + ++E E L
Sbjct: 1003 QSLGMCPQHNILFHHLTVAEHMLFYAQLK-----GKSQEEAQLE---MEAMLEDTGLHHK 1054
Query: 206 GNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLV 265
N + LSGG +R++S+ + + + ++ILDEPTSG+D ++ ++ L + G ++
Sbjct: 1055 RNEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTII 1114
Query: 266 LISLHQPRSDIFRLFDLVLLMT------SGTPIYL 294
+ + H +D+ L D + ++ SGTP++L
Sbjct: 1115 MSTHHMDEADL--LGDRIAIIAQGRLYCSGTPLFL 1147
Score = 61.2 bits (147), Expect = 3e-09
Identities = 53/219 (24%), Positives = 96/219 (43%), Gaps = 14/219 (6%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL--VR 145
+ L VR G+ ++G +G G+ + ++TG + SG + G+ + V
Sbjct: 1955 VDRLCVGVRPGECFGLLGVNGAGKTTTFKMLTG---DTTVTSGDATVAGKSILTNISEVH 2011
Query: 146 KCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRV 205
+ + + Q + + LT RE L A++R + +K I L L AD
Sbjct: 2012 QNMGYCPQFDAIDELLTGREHLYLYARLR---GVPAEEIEKVANWSIKSLGLTVYADCLA 2068
Query: 206 GNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLV 265
G SGG +R++S + L+ P +++LDEPT+G+D L + + + R V
Sbjct: 2069 GTY-----SGGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAV 2123
Query: 266 LISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
+++ H + L + +M G +G QH+ F
Sbjct: 2124 VLTSHS-MEECEALCTRLAIMVKGAFRCMGTIQHLKSKF 2161
>gi|6005701 ATP-binding cassette, sub-family A member 8 [Homo sapiens]
Length = 1581
Score = 80.1 bits (196), Expect = 6e-15
Identities = 59/221 (26%), Positives = 114/221 (51%), Gaps = 15/221 (6%)
Query: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLV 144
++ +N+SF VR G++L ++G +G G+++ + VITG K +GQ+ + G L
Sbjct: 1263 KIATRNVSFCVRKGEVLGLLGHNGAGKSTSIKVITG---DTKPTAGQVLLKGSGGGDAL- 1318
Query: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR 204
+ + + Q N L PNLTVR+ L A ++ R + + + ++ L+L+ +
Sbjct: 1319 -EFLGYCPQENALWPNLTVRQHLEVYAAVKGLR---KGDAEVAITRLVDALKLQDQLKSP 1374
Query: 205 VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTL-SRLAKGNR 263
V+ LS G +R++ + +L NP +++LDEP++G+D + + + + R
Sbjct: 1375 -----VKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTER 1429
Query: 264 LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
L++ H ++ + D V +M SG +G+ QH+ F
Sbjct: 1430 GALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKF 1469
Score = 45.4 bits (106), Expect = 2e-04
Identities = 68/288 (23%), Positives = 120/288 (41%), Gaps = 66/288 (22%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWIN--GQPSSPQLVR 145
+++L F + GQ+ AI+G SG G+++LL++++G K S I+ N + + + +
Sbjct: 499 LKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTK-GSVTIYNNKLSEMADLENLS 557
Query: 146 KCVAHVRQHNQLLPNLTVRETLAFIAQMR--LPRTFSQAQRDKRVEDVIAELRLRQCADT 203
K Q N LTVRE L A+++ LP+ + DK
Sbjct: 558 KLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQ-----EVDKE---------------- 596
Query: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263
I +LDEPT+GLD F+ H V L + K +R
Sbjct: 597 -----------------------------IFLLDEPTAGLDPFSRHQ-VWNLLKERKTDR 626
Query: 264 LVLISLH-QPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYV 322
++L S +DI L D + ++ G G++ + + + IGY N
Sbjct: 627 VILFSTQFMDEADI--LADRKVFLSQGKLKCAGSSLFLKKKW-GIGYHLSLQLNEICVEE 683
Query: 323 DLTS-IDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLD 369
++TS + + + +L+ + + + + L LE+ + KDLD
Sbjct: 684 NITSLVKQHIPDAKLSAKSEGKLIYTLPLERTNKFPELY-----KDLD 726
>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
[Homo sapiens]
Length = 2436
Score = 77.4 bits (189), Expect = 4e-14
Identities = 59/221 (26%), Positives = 101/221 (45%), Gaps = 14/221 (6%)
Query: 86 LGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL-- 143
L + L VR G+ ++G +G G+ S ++TG G+ ++NG +L
Sbjct: 2069 LAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTG---DESTTGGEAFVNGHSVLKELLQ 2125
Query: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADT 203
V++ + + Q + L LT RE L ++R S + V+ + +L L + AD
Sbjct: 2126 VQQSLGYCPQCDALFDELTAREHLQLYTRLR---GISWKDEARVVKWALEKLELTKYADK 2182
Query: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263
G SGG +R++S + L+ P + LDEPT+G+D L + L K R
Sbjct: 2183 PAGTY-----SGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGR 2237
Query: 264 LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
V+++ H + L + +M +G LG+ QH+ F
Sbjct: 2238 SVVLTSHS-MEECEALCTRLAIMVNGRLRCLGSIQHLKNRF 2277
Score = 75.5 bits (184), Expect = 2e-13
Identities = 51/207 (24%), Positives = 105/207 (50%), Gaps = 15/207 (7%)
Query: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL- 143
+L + LS + Q+++ +G +G G+ + + ++TG SG I G ++
Sbjct: 1005 KLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPP---TSGSATIYGHDIRTEMD 1061
Query: 144 -VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCAD 202
+RK + QHN L LTV E L F ++++ + +Q + + ++ +I +L L
Sbjct: 1062 EIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLK---SMAQEEIRREMDKMIEDLEL----- 1113
Query: 203 TRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGN 262
+ + V+ LSGG +R++S+ + + +ILDEPT+G+D + + + + G
Sbjct: 1114 SNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGR 1173
Query: 263 RLVLISLHQPRSDIFRLFDLVLLMTSG 289
++L + H +D+ L D + +++ G
Sbjct: 1174 TILLSTHHMDEADL--LGDRIAIISHG 1198
>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
[Homo sapiens]
Length = 2466
Score = 77.4 bits (189), Expect = 4e-14
Identities = 59/221 (26%), Positives = 101/221 (45%), Gaps = 14/221 (6%)
Query: 86 LGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL-- 143
L + L VR G+ ++G +G G+ S ++TG G+ ++NG +L
Sbjct: 2099 LAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTG---DESTTGGEAFVNGHSVLKELLQ 2155
Query: 144 VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADT 203
V++ + + Q + L LT RE L ++R S + V+ + +L L + AD
Sbjct: 2156 VQQSLGYCPQCDALFDELTAREHLQLYTRLR---GISWKDEARVVKWALEKLELTKYADK 2212
Query: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263
G SGG +R++S + L+ P + LDEPT+G+D L + L K R
Sbjct: 2213 PAGTY-----SGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGR 2267
Query: 264 LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
V+++ H + L + +M +G LG+ QH+ F
Sbjct: 2268 SVVLTSHS-MEECEALCTRLAIMVNGRLRCLGSIQHLKNRF 2307
Score = 75.5 bits (184), Expect = 2e-13
Identities = 51/207 (24%), Positives = 105/207 (50%), Gaps = 15/207 (7%)
Query: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL- 143
+L + LS + Q+++ +G +G G+ + + ++TG SG I G ++
Sbjct: 1035 KLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPP---TSGSATIYGHDIRTEMD 1091
Query: 144 -VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCAD 202
+RK + QHN L LTV E L F ++++ + +Q + + ++ +I +L L
Sbjct: 1092 EIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLK---SMAQEEIRREMDKMIEDLEL----- 1143
Query: 203 TRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGN 262
+ + V+ LSGG +R++S+ + + +ILDEPT+G+D + + + + G
Sbjct: 1144 SNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGR 1203
Query: 263 RLVLISLHQPRSDIFRLFDLVLLMTSG 289
++L + H +D+ L D + +++ G
Sbjct: 1204 TILLSTHHMDEADL--LGDRIAIISHG 1228
>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
[Homo sapiens]
Length = 2277
Score = 77.0 bits (188), Expect = 5e-14
Identities = 57/220 (25%), Positives = 109/220 (49%), Gaps = 17/220 (7%)
Query: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL- 143
++ + NL+ G + +++G +G G+ + + ++TG +G I++ G+ L
Sbjct: 1040 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGAS---AGTIFVYGKDIKTDLH 1096
Query: 144 -VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCAD 202
VRK + QH+ L LT +E L +++P +++ Q + V+ + + L
Sbjct: 1097 TVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH-WTKKQLHEEVKRTLKDTGLYSHRH 1155
Query: 203 TRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGN 262
RVG LSGG +R++SI + L+ ++ILDEP++G+D + ++ +S+ K
Sbjct: 1156 KRVGT-----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK-NKTA 1209
Query: 263 RLVLISLH-----QPRSDIFRLFDLVLLMTSGTPIYLGAA 297
R +++S H + SD + L G+P YL A
Sbjct: 1210 RTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEA 1249
Score = 62.8 bits (151), Expect = 1e-09
Identities = 56/222 (25%), Positives = 103/222 (46%), Gaps = 15/222 (6%)
Query: 86 LGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLV- 144
+ + N+S + +G+ ++G +G G+ ++ ++TG SG I I + S V
Sbjct: 1953 IAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPS---SGNILIRNKTGSLGHVD 2009
Query: 145 --RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCAD 202
V + Q + L +TV E L F A++ + + V ++ L L D
Sbjct: 2010 SHSSLVGYCPQEDALDDLVTVEEHLYFYARVH---GIPEKDIKETVHKLLRRLHLMPFKD 2066
Query: 203 TRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGN 262
R +M S G +R++S + L+ P IL+LDEP+SG+D + +L K +S +
Sbjct: 2067 -RATSM----CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNK 2121
Query: 263 RLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
V+++ H + L + +M +G +G+ QH+ F
Sbjct: 2122 CSVILTSHS-MEECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2162
>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
[Homo sapiens]
Length = 2595
Score = 77.0 bits (188), Expect = 5e-14
Identities = 57/220 (25%), Positives = 109/220 (49%), Gaps = 17/220 (7%)
Query: 85 ELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL- 143
++ + NL+ G + +++G +G G+ + + ++TG +G I++ G+ L
Sbjct: 1358 KVAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGAS---AGTIFVYGKDIKTDLH 1414
Query: 144 -VRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCAD 202
VRK + QH+ L LT +E L +++P +++ Q + V+ + + L
Sbjct: 1415 TVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPH-WTKKQLHEEVKRTLKDTGLYSHRH 1473
Query: 203 TRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGN 262
RVG LSGG +R++SI + L+ ++ILDEP++G+D + ++ +S+ K
Sbjct: 1474 KRVGT-----LSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK-NKTA 1527
Query: 263 RLVLISLH-----QPRSDIFRLFDLVLLMTSGTPIYLGAA 297
R +++S H + SD + L G+P YL A
Sbjct: 1528 RTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEA 1567
Score = 62.8 bits (151), Expect = 1e-09
Identities = 56/222 (25%), Positives = 103/222 (46%), Gaps = 15/222 (6%)
Query: 86 LGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLV- 144
+ + N+S + +G+ ++G +G G+ ++ ++TG SG I I + S V
Sbjct: 2271 IAVNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPS---SGNILIRNKTGSLGHVD 2327
Query: 145 --RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCAD 202
V + Q + L +TV E L F A++ + + V ++ L L D
Sbjct: 2328 SHSSLVGYCPQEDALDDLVTVEEHLYFYARVH---GIPEKDIKETVHKLLRRLHLMPFKD 2384
Query: 203 TRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGN 262
R +M S G +R++S + L+ P IL+LDEP+SG+D + +L K +S +
Sbjct: 2385 -RATSM----CSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNK 2439
Query: 263 RLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
V+++ H + L + +M +G +G+ QH+ F
Sbjct: 2440 CSVILTSHS-MEECEALCTRLAIMVNGKFQCIGSLQHIKSRF 2480
>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
sapiens]
Length = 2261
Score = 72.8 bits (177), Expect = 1e-12
Identities = 50/219 (22%), Positives = 108/219 (49%), Gaps = 14/219 (6%)
Query: 81 QNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQP-- 138
++ ++ + L+ GQ+ + +G +G G+ + + ++TG SG +I G+
Sbjct: 909 RDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPP---TSGTAYILGKDIR 965
Query: 139 SSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLR 198
S +R+ + QHN L LTV E + F A+++ +K V+ + ++ L
Sbjct: 966 SEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLK-------GLSEKHVKAEMEQMALD 1018
Query: 199 QCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRL 258
+ LSGG +R++S+ + + ++ILDEPT+G+D ++ + + L +
Sbjct: 1019 VGLPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKY 1078
Query: 259 AKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAA 297
+G ++L + H +D+ L D + +++ G +G++
Sbjct: 1079 RQGRTIILSTHHMDEADV--LGDRIAIISHGKLCCVGSS 1115
Score = 66.6 bits (161), Expect = 7e-11
Identities = 53/219 (24%), Positives = 98/219 (44%), Gaps = 14/219 (6%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQP--SSPQLVR 145
+ + + G+ ++G +G G++S ++TG + G ++N S+ V
Sbjct: 1929 VDRICVGIPPGECFGLLGVNGAGKSSTFKMLTG---DTTVTRGDAFLNKNSILSNIHEVH 1985
Query: 146 KCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRV 205
+ + + Q + + LT RE + F A +R +K V V E +R+ +
Sbjct: 1986 QNMGYCPQFDAITELLTGREHVEFFALLR-------GVPEKEVGKV-GEWAIRKLGLVKY 2037
Query: 206 GNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLV 265
G Y SGG +R++S + L+ P ++ LDEPT+G+D L + K R V
Sbjct: 2038 GEKYAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSV 2097
Query: 266 LISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYF 304
+++ H + L + +M +G LG+ QH+ F
Sbjct: 2098 VLTSHS-MEECEALCTRMAIMVNGRFRCLGSVQHLKNRF 2135
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 72.4 bits (176), Expect = 1e-12
Identities = 60/187 (32%), Positives = 100/187 (53%), Gaps = 10/187 (5%)
Query: 89 QNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWING---QPSSPQLVR 145
Q+ S + SG + A++G SG G++++L ++ SG I ++G + +P +R
Sbjct: 511 QDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPA---SGTISLDGHDIRQLNPVWLR 567
Query: 146 KCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELR-LRQCADTR 204
+ V Q +L + ++ E +A+ A T + QR V + +A +R Q +T
Sbjct: 568 SKIGTVSQE-PILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTV 626
Query: 205 VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRL 264
VG V LSGG+++R++I LL NP IL+LDE TS LD+ + + + L RL G R
Sbjct: 627 VGEKGVL-LSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDG-RT 684
Query: 265 VLISLHQ 271
VL+ H+
Sbjct: 685 VLVIAHR 691
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 70.9 bits (172), Expect = 4e-12
Identities = 54/184 (29%), Positives = 98/184 (53%), Gaps = 10/184 (5%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPS---SPQLV 144
++ L+ KV+SGQ +A++GSSGCG+++ + +I + G I I+GQ + +
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE---GTINIDGQDIRNFNVNYL 468
Query: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR 204
R+ + V Q L + T+ E + + +A ++ + I ++L Q DT
Sbjct: 469 REIIGVVSQEPVLF-STTIAENICYGRGNVTMDEIKKAVKEANAYEFI--MKLPQKFDTL 525
Query: 205 VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRL 264
VG + LSGG+++R++I L+ NP IL+LDE TS LD+ + + L + +G
Sbjct: 526 VGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTT 584
Query: 265 VLIS 268
++I+
Sbjct: 585 IVIA 588
Score = 65.9 bits (159), Expect = 1e-10
Identities = 60/226 (26%), Positives = 113/226 (50%), Gaps = 22/226 (9%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLL-------DVITGR---GHGGKIKSGQIWINGQ 137
+Q LS +V+ GQ LA++GSSGCG+++++ D + G G ++ GQ +
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQ---EAK 1108
Query: 138 PSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRT--FSQAQRDKRVEDVIAEL 195
+ Q +R + V Q +L + ++ E +A+ R+ A + + I L
Sbjct: 1109 KLNVQWLRAQLGIVSQE-PILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETL 1167
Query: 196 RLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTL 255
+ +TRVG+ + LSGG+++R++I L+ P IL+LDE TS LD+ + + + L
Sbjct: 1168 PHKY--ETRVGDKGTQ-LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEAL 1224
Query: 256 SRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMV 301
+ +G ++I+ R + DL+++ +G G Q ++
Sbjct: 1225 DKAREGRTCIVIA---HRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1267
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 70.9 bits (172), Expect = 4e-12
Identities = 54/184 (29%), Positives = 98/184 (53%), Gaps = 10/184 (5%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPS---SPQLV 144
++ L+ KV+SGQ +A++GSSGCG+++ + +I + G I I+GQ + +
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE---GTINIDGQDIRNFNVNYL 468
Query: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR 204
R+ + V Q L + T+ E + + +A ++ + I ++L Q DT
Sbjct: 469 REIIGVVSQEPVLF-STTIAENICYGRGNVTMDEIKKAVKEANAYEFI--MKLPQKFDTL 525
Query: 205 VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRL 264
VG + LSGG+++R++I L+ NP IL+LDE TS LD+ + + L + +G
Sbjct: 526 VGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTT 584
Query: 265 VLIS 268
++I+
Sbjct: 585 IVIA 588
Score = 68.6 bits (166), Expect = 2e-11
Identities = 58/219 (26%), Positives = 113/219 (51%), Gaps = 15/219 (6%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSP---QLV 144
+Q LS +V+ GQ LA++GSSGCG+++++ ++ +G + ++GQ + Q +
Sbjct: 1005 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE---RFYDPLAGTVLLDGQEAKKLNVQWL 1061
Query: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRT--FSQAQRDKRVEDVIAELRLRQCAD 202
R + V Q +L + ++ E +A+ R+ A + + I L + +
Sbjct: 1062 RAQLGIVSQE-PILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKY--E 1118
Query: 203 TRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGN 262
TRVG+ + LSGG+++R++I L+ P IL+LDE TS LD+ + + + L + +G
Sbjct: 1119 TRVGDKGTQ-LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR 1177
Query: 263 RLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMV 301
++I+ R + DL+++ +G G Q ++
Sbjct: 1178 TCIVIA---HRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1213
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 70.9 bits (172), Expect = 4e-12
Identities = 54/184 (29%), Positives = 98/184 (53%), Gaps = 10/184 (5%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPS---SPQLV 144
++ L+ KV+SGQ +A++GSSGCG+++ + +I + G I I+GQ + +
Sbjct: 412 LKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDE---GTINIDGQDIRNFNVNYL 468
Query: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR 204
R+ + V Q L + T+ E + + +A ++ + I ++L Q DT
Sbjct: 469 REIIGVVSQEPVLF-STTIAENICYGRGNVTMDEIKKAVKEANAYEFI--MKLPQKFDTL 525
Query: 205 VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRL 264
VG + LSGG+++R++I L+ NP IL+LDE TS LD+ + + L + +G
Sbjct: 526 VGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTT 584
Query: 265 VLIS 268
++I+
Sbjct: 585 IVIA 588
Score = 68.6 bits (166), Expect = 2e-11
Identities = 58/219 (26%), Positives = 113/219 (51%), Gaps = 15/219 (6%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSP---QLV 144
+Q LS +V+ GQ LA++GSSGCG+++++ ++ +G + ++GQ + Q +
Sbjct: 1052 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE---RFYDPLAGTVLLDGQEAKKLNVQWL 1108
Query: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRT--FSQAQRDKRVEDVIAELRLRQCAD 202
R + V Q +L + ++ E +A+ R+ A + + I L + +
Sbjct: 1109 RAQLGIVSQE-PILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKY--E 1165
Query: 203 TRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGN 262
TRVG+ + LSGG+++R++I L+ P IL+LDE TS LD+ + + + L + +G
Sbjct: 1166 TRVGDKGTQ-LSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGR 1224
Query: 263 RLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMV 301
++I+ R + DL+++ +G G Q ++
Sbjct: 1225 TCIVIA---HRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1260
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 69.3 bits (168), Expect = 1e-11
Identities = 51/184 (27%), Positives = 98/184 (53%), Gaps = 10/184 (5%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPS---SPQLV 144
++ L+ KV+SGQ +A++G+SGCG+++ + ++ + G + ++GQ + + +
Sbjct: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTE---GMVSVDGQDIRTINVRFL 466
Query: 145 RKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTR 204
R+ + V Q L T+ E + + + +A ++ D I ++L DT
Sbjct: 467 REIIGVVSQEPVLFAT-TIAENIRYGRENVTMDEIEKAVKEANAYDFI--MKLPHKFDTL 523
Query: 205 VGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRL 264
VG + LSGG+++R++I L+ NP IL+LDE TS LD+ + + L + KG
Sbjct: 524 VGERGAQ-LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTT 582
Query: 265 VLIS 268
++I+
Sbjct: 583 IVIA 586
Score = 69.3 bits (168), Expect = 1e-11
Identities = 56/218 (25%), Positives = 115/218 (52%), Gaps = 13/218 (5%)
Query: 88 IQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKC 147
+Q LS +V+ GQ LA++GSSGCG+++++ ++ +G++ ++G+ V+
Sbjct: 1053 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE---RFYDPLAGKVLLDGKEIKRLNVQWL 1109
Query: 148 VAHVRQHNQ--LLPNLTVRETLAFIAQMRL--PRTFSQAQRDKRVEDVIAELRLRQCADT 203
AH+ +Q +L + ++ E +A+ R+ +A ++ + I L + T
Sbjct: 1110 RAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKY--ST 1167
Query: 204 RVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNR 263
+VG+ + LSGG+++R++I L+ P IL+LDE TS LD+ + + + L + +G
Sbjct: 1168 KVGDKGTQ-LSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1226
Query: 264 LVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMV 301
++I+ R + DL+++ +G G Q ++
Sbjct: 1227 CIVIA---HRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1261
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,722,670
Number of Sequences: 37866
Number of extensions: 1087285
Number of successful extensions: 3594
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3304
Number of HSP's gapped (non-prelim): 177
length of query: 673
length of database: 18,247,518
effective HSP length: 109
effective length of query: 564
effective length of database: 14,120,124
effective search space: 7963749936
effective search space used: 7963749936
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.