Search of human proteins with 11967969

Search of human proteins with 11967969

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
sapiens]
         (651 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11967969 ATP-binding cassette sub-family G member 5 [Homo sap...  1285   0.0  
gi|11967971 ATP-binding cassette sub-family G member 8 [Homo sap...   256   4e-68
gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo s...   249   7e-66
gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4...   219   6e-57
gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo s...   212   8e-55
gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo sa...   212   8e-55
gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7...   209   5e-54
gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6...   209   5e-54
gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5...   209   5e-54
gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3...   209   5e-54
gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2...   209   5e-54
gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo s...    90   6e-18
gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform...    89   1e-17
gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform...    89   1e-17
gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo s...    87   6e-17
gi|27881501 ATP-binding cassette, sub-family A, member 12 isofor...    82   2e-15
gi|30795238 ATP-binding cassette, sub-family A, member 12 isofor...    82   2e-15
gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo s...    80   6e-15
gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo s...    79   1e-14
gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo ...    79   1e-14
gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13...    78   2e-14
gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo ...    76   8e-14
gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo ...    76   8e-14
gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo sa...    75   1e-13
gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo...    74   4e-13
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa...    73   7e-13
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B...    73   7e-13
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C...    73   7e-13
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A...    73   7e-13
gi|90421313 cystic fibrosis transmembrane conductance regulator ...    70   6e-12

>gi|11967969 ATP-binding cassette sub-family G member 5 [Homo
           sapiens]
          Length = 651

 Score = 1285 bits (3326), Expect = 0.0
 Identities = 651/651 (100%), Positives = 651/651 (100%)

Query: 1   MGDLSSLTPGGSMGLQVNRGSQSSLEGAPATAPEPHSLGILHASYSVSHRVRPWWDITSC 60
           MGDLSSLTPGGSMGLQVNRGSQSSLEGAPATAPEPHSLGILHASYSVSHRVRPWWDITSC
Sbjct: 1   MGDLSSLTPGGSMGLQVNRGSQSSLEGAPATAPEPHSLGILHASYSVSHRVRPWWDITSC 60

Query: 61  RQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRAL 120
           RQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRAL
Sbjct: 61  RQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRAL 120

Query: 121 RREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHV 180
           RREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHV
Sbjct: 121 RREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHV 180

Query: 181 ADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELAR 240
           ADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELAR
Sbjct: 181 ADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELAR 240

Query: 241 RNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDF 300
           RNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDF
Sbjct: 241 RNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDF 300

Query: 301 YMDLTSVDTQSKEREIETSKRVQMIESAYKKSAICHKTLKNIERMKHLKTLPMVPFKTKD 360
           YMDLTSVDTQSKEREIETSKRVQMIESAYKKSAICHKTLKNIERMKHLKTLPMVPFKTKD
Sbjct: 301 YMDLTSVDTQSKEREIETSKRVQMIESAYKKSAICHKTLKNIERMKHLKTLPMVPFKTKD 360

Query: 361 SPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRV 420
           SPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRV
Sbjct: 361 SPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRV 420

Query: 421 GLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATM 480
           GLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATM
Sbjct: 421 GLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATM 480

Query: 481 IFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIA 540
           IFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIA
Sbjct: 481 IFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIA 540

Query: 541 GVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSNVSVTTNPMC 600
           GVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSNVSVTTNPMC
Sbjct: 541 GVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSNVSVTTNPMC 600

Query: 601 AFTQGIQFIEKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLISR 651
           AFTQGIQFIEKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLISR
Sbjct: 601 AFTQGIQFIEKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLISR 651


>gi|11967971 ATP-binding cassette sub-family G member 8 [Homo
           sapiens]
          Length = 673

 Score =  256 bits (655), Expect = 4e-68
 Identities = 180/615 (29%), Positives = 312/615 (50%), Gaps = 30/615 (4%)

Query: 8   TPGGSMGLQVNRGSQSSLEGAPAT-APEPHSLGILHASYSVSHRVR-PWWD-ITSCRQQW 64
           TP  + GLQ    S  S      T + +P++L +   +Y V    + PW++ +   +  W
Sbjct: 16  TPQDTSGLQDRLFSSESDNSLYFTYSGQPNTLEVRDLNYQVDLASQVPWFEQLAQFKMPW 75

Query: 65  TRQI--------LKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFL-GEVYV 115
           T           ++++S  V SGQ++ I+GSSG G+ +LLD ++GR G  G    G++++
Sbjct: 76  TSPSCQNSCELGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGR-GHGGKIKSGQIWI 134

Query: 116 NGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRG-NPGSFQKKVEAVMAE 174
           NG+    +  + C ++V Q + LL +LTVRETL + A + + R  +     K+VE V+AE
Sbjct: 135 NGQPSSPQLVRKCVAHVRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAE 194

Query: 175 LSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVL 234
           L L   AD  +GN  + G+S GERRRVSI  QLL +P +++ DEPT+GLD  TA+ +V  
Sbjct: 195 LRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKT 254

Query: 235 LVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEH 294
           L  LA+ NR+V++++HQPRS++F+LFD + +++ G  I+ G    M+ +F   GYPCP +
Sbjct: 255 LSRLAKGNRLVLISLHQPRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRY 314

Query: 295 SNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSA------ICHKTLKNIERMKHL 348
           SNP DFY+DLTS+D +S+E+E+ T ++ Q + + + +        +     K+++    +
Sbjct: 315 SNPADFYVDLTSIDRRSREQELATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCV 374

Query: 349 KT--LPM----VPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLF 402
           ++   P+    +P  TK  PG   +   L+RR   N  R+   ++    +  +M + + F
Sbjct: 375 ESSVTPLDTNCLPSPTK-MPGAVQQFTTLIRRQISNDFRDLPTLLIHGAEACLMSMTIGF 433

Query: 403 FVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQ 462
             L      ++ +  D   LL+      P+  +L+ ++     RA+   E +DGLY    
Sbjct: 434 --LYFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGP 491

Query: 463 MMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLG 522
              A  L  LP      +I+    YW   L P +  F      +         + L    
Sbjct: 492 YFFAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAA 551

Query: 523 IVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYG 582
           ++   ++ +     L  +  L G GF+ N+  +      IS  +F ++C E L+  +F  
Sbjct: 552 LLPTFHMASFFSNALYNSFYLAG-GFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSR 610

Query: 583 LNFTCGSSNVSVTTN 597
             +     N+++  +
Sbjct: 611 RTYKMPLGNLTIAVS 625


>gi|62526033 ATP-binding cassette, sub-family G, member 2 [Homo
           sapiens]
          Length = 655

 Score =  249 bits (635), Expect = 7e-66
 Identities = 179/611 (29%), Positives = 317/611 (51%), Gaps = 47/611 (7%)

Query: 21  SQSSLEGAPATAP---EPHSLGILHASYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVE 77
           SQ +  G PATA    +  + G + + +++ +RV+       CR+   ++IL +++  ++
Sbjct: 13  SQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMK 72

Query: 78  SGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDT 137
            G +  ILG +G GK++LLD ++ R   +G   G+V +NG A R   F+    YV+Q D 
Sbjct: 73  PG-LNAILGPTGGGKSSLLDVLAARKDPSG-LSGDVLING-APRPANFKCNSGYVVQDDV 129

Query: 138 LLSSLTVRETLHYTALLAIRRGNPGSFQ-KKVEAVMAELSLSHVADRLIGNYSLGGISTG 196
           ++ +LTVRE L ++A L +        + +++  V+ EL L  VAD  +G   + G+S G
Sbjct: 130 VMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGG 189

Query: 197 ERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSEL 256
           ER+R SI  +L+ DP ++  DEPTTGLD  TAN +++LL  ++++ R ++ +IHQPR  +
Sbjct: 190 ERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSI 249

Query: 257 FQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQ----SK 312
           F+LFD + +L+ G L+F G   E L +F   GY C  ++NP DF++D+ + D+     ++
Sbjct: 250 FKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNR 309

Query: 313 ERE------IETSKR----VQMIESAYKKSAICHKT------LKNIERMKHLKTLPMVPF 356
           E +      IE SK+    ++ +   Y  S+   +T      L   E+ K +     + +
Sbjct: 310 EEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISY 369

Query: 357 KTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFL--LFFVLRVRSNVLKG 414
            T        +L  + +R  +NL+ N  A I +++  +++GL +  ++F L+  S     
Sbjct: 370 TT----SFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDST---- 421

Query: 415 AIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYAL-HVLP 473
            IQ+R G+L+ F+        ++AV LF V + +   E   G Y+     L   L  +LP
Sbjct: 422 GIQNRAGVLF-FLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP 480

Query: 474 FSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSV 533
             ++ ++IF+ + Y+ LGL P+   F      L+   ++    + + L I    ++V+  
Sbjct: 481 MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLM---MVAYSASSMALAIAAGQSVVSVA 537

Query: 534 VALLSIAGV--LVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSN 591
             L++I  V  ++ SG L N+  +      + YF+  +Y    L  NEF G NF  G   
Sbjct: 538 TLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPG--- 594

Query: 592 VSVTTNPMCAF 602
           ++ T N  C +
Sbjct: 595 LNATGNNPCNY 605


>gi|46592915 ATP-binding cassette sub-family G member 1 isoform 4
           [Homo sapiens]
          Length = 678

 Score =  219 bits (558), Expect = 6e-57
 Identities = 163/617 (26%), Positives = 305/617 (49%), Gaps = 39/617 (6%)

Query: 44  SYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRL 103
           SYSV     PWW     R++  + +LK +S    SG+++ I+G SG+GK+TL++ ++G  
Sbjct: 83  SYSVPEG--PWW-----RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGY- 134

Query: 104 GRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS 163
            R     G V +NG       F+    Y++Q D LL  LTV+E +  +A L ++  + G 
Sbjct: 135 -RETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR 193

Query: 164 FQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGL 223
            ++ V+ ++  L L   A     N   G +S G+R+R++IA +L+ +P VM FDEPT+GL
Sbjct: 194 -REMVKEILTALGLLSCA-----NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 247

Query: 224 DCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDF 283
           D  +  Q+V L+  LA+  R ++ TIHQP ++LF+LFD++ +LS G+ ++ G    ++ +
Sbjct: 248 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPY 307

Query: 284 FNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSA---------I 334
             D G  CP + NP DF M++ S +   +   +  + R  M +S +K+           +
Sbjct: 308 LRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFL 367

Query: 335 CHKTLKNIERMKHLKTLPMVPFKTKD----SPGVFSKLGVLLRRVTRNLVRNKLAVITRL 390
            H+  + +++ K LK L       +     S    ++  +L +R   +++R+ +    R+
Sbjct: 368 WHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRI 427

Query: 391 LQNLIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSD 450
             ++ +GL +    L + +   K  +    G L+  +    +  ++  V  FP+   V  
Sbjct: 428 TSHIGIGLLIGLLYLGIGNEAKK--VLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFL 485

Query: 451 QESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPH 510
           +E  +  Y      LA  +  +PF ++  + + S+ YW      +  RF  F+A      
Sbjct: 486 REHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTS 545

Query: 511 LIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKY 570
           L+ + L L L+G       V + V  ++   VL+ SGF  +   +P   + +SY ++ +Y
Sbjct: 546 LVAQSLGL-LIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRY 604

Query: 571 CSEILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSRFTMNFLILYSF 630
             E ++++  YGL+      ++    +  C F Q  + I +      ++  ++F++L  F
Sbjct: 605 GFEGVILS-IYGLD----REDLHCDIDETCHF-QKSEAILRELDVENAKLYLDFIVLGIF 658

Query: 631 IPALVILGIVV--FKIR 645
             +L ++   V  +KIR
Sbjct: 659 FISLRLIAYFVLRYKIR 675


>gi|215820660 ATP-binding cassette, subfamily G, member 4 [Homo
           sapiens]
          Length = 646

 Score =  212 bits (540), Expect = 8e-55
 Identities = 170/626 (27%), Positives = 296/626 (47%), Gaps = 51/626 (8%)

Query: 33  PEPHSLGILHASYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGK 92
           P+  ++ I     S S R  P W     R++  + +LK +S      +++ I+G SG+GK
Sbjct: 54  PKRSAVDIEFVELSYSVREGPCW-----RKRGYKTLLKCLSGKFCRRELIGIMGPSGAGK 108

Query: 93  TTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTA 152
           +T ++ ++G   R     G++ VNGR      F+    Y++Q D LL  LTV E +  +A
Sbjct: 109 STFMNILAGY--RESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSA 166

Query: 153 LLAIRRGNPGSFQKKVEAVMAE--LSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQD 210
            L +        +   E + A   +S SH    L+        S G+R+R++IA +L+ +
Sbjct: 167 NLKLSEKQEVKKELVTEILTALGLMSCSHTRTALL--------SGGQRKRLAIALELVNN 218

Query: 211 PKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGE 270
           P VM FDEPT+GLD  +  Q+V L+  LA+  R ++ TIHQP ++LF++FDK+ ILS G+
Sbjct: 219 PPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQ 278

Query: 271 LIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYK 330
            IF G    ++ +    G  CP + NP DF +++ S          E      M+  A  
Sbjct: 279 CIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASG---------EYGDLNPMLFRAV- 328

Query: 331 KSAICHKTLKNIERMKHLKTLPMVPFKTKDSP--------GVFSKLGVLLRRVTRNLVRN 382
           ++ +C    K     K+    P  P   +  P           ++  +L +R   +++R+
Sbjct: 329 QNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRD 388

Query: 383 KLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLF 442
            +    R + ++++G+ +    L +  +  K  + +  G L+  +    +  ++  V  F
Sbjct: 389 TVLTHLRFMSHVVIGVLIGLLYLHIGDDASK--VFNNTGCLFFSMLFLMFAALMPTVLTF 446

Query: 443 PVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYF 502
           P+  AV  +E  +  Y      LA  +  +PF VV  +++ S+ YW  G   E +RF  F
Sbjct: 447 PLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLF 506

Query: 503 SAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKII 562
           SA   A  L+ + L L L+G   N   V + V  ++   VL+ SGF  + + +P   +  
Sbjct: 507 SALATATALVAQSLGL-LIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWS 565

Query: 563 SYFTFQKYCSEILVVNEFYGL---NFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSR 619
           SY ++ +Y  E +++   YG+   + TC            C F +  Q I +      ++
Sbjct: 566 SYLSYVRYGFEGVILT-IYGMERGDLTC--------LEERCPFREP-QSILRALDVEDAK 615

Query: 620 FTMNFLILYSFIPALVILGIVVFKIR 645
             M+FL+L  F  AL +L  +V + R
Sbjct: 616 LYMDFLVLGIFFLALRLLAYLVLRYR 641


>gi|20143975 ATP-binding cassette, subfamily G, member 4 [Homo
           sapiens]
          Length = 646

 Score =  212 bits (540), Expect = 8e-55
 Identities = 170/626 (27%), Positives = 296/626 (47%), Gaps = 51/626 (8%)

Query: 33  PEPHSLGILHASYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGK 92
           P+  ++ I     S S R  P W     R++  + +LK +S      +++ I+G SG+GK
Sbjct: 54  PKRSAVDIEFVELSYSVREGPCW-----RKRGYKTLLKCLSGKFCRRELIGIMGPSGAGK 108

Query: 93  TTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTA 152
           +T ++ ++G   R     G++ VNGR      F+    Y++Q D LL  LTV E +  +A
Sbjct: 109 STFMNILAGY--RESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSA 166

Query: 153 LLAIRRGNPGSFQKKVEAVMAE--LSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQD 210
            L +        +   E + A   +S SH    L+        S G+R+R++IA +L+ +
Sbjct: 167 NLKLSEKQEVKKELVTEILTALGLMSCSHTRTALL--------SGGQRKRLAIALELVNN 218

Query: 211 PKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGE 270
           P VM FDEPT+GLD  +  Q+V L+  LA+  R ++ TIHQP ++LF++FDK+ ILS G+
Sbjct: 219 PPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQ 278

Query: 271 LIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYK 330
            IF G    ++ +    G  CP + NP DF +++ S          E      M+  A  
Sbjct: 279 CIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASG---------EYGDLNPMLFRAV- 328

Query: 331 KSAICHKTLKNIERMKHLKTLPMVPFKTKDSP--------GVFSKLGVLLRRVTRNLVRN 382
           ++ +C    K     K+    P  P   +  P           ++  +L +R   +++R+
Sbjct: 329 QNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRD 388

Query: 383 KLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLF 442
            +    R + ++++G+ +    L +  +  K  + +  G L+  +    +  ++  V  F
Sbjct: 389 TVLTHLRFMSHVVIGVLIGLLYLHIGDDASK--VFNNTGCLFFSMLFLMFAALMPTVLTF 446

Query: 443 PVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYF 502
           P+  AV  +E  +  Y      LA  +  +PF VV  +++ S+ YW  G   E +RF  F
Sbjct: 447 PLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLF 506

Query: 503 SAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKII 562
           SA   A  L+ + L L L+G   N   V + V  ++   VL+ SGF  + + +P   +  
Sbjct: 507 SALATATALVAQSLGL-LIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWS 565

Query: 563 SYFTFQKYCSEILVVNEFYGL---NFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSR 619
           SY ++ +Y  E +++   YG+   + TC            C F +  Q I +      ++
Sbjct: 566 SYLSYVRYGFEGVILT-IYGMERGDLTC--------LEERCPFREP-QSILRALDVEDAK 615

Query: 620 FTMNFLILYSFIPALVILGIVVFKIR 645
             M+FL+L  F  AL +L  +V + R
Sbjct: 616 LYMDFLVLGIFFLALRLLAYLVLRYR 641


>gi|46592978 ATP-binding cassette sub-family G member 1 isoform 7
           [Homo sapiens]
          Length = 663

 Score =  209 bits (533), Expect = 5e-54
 Identities = 160/614 (26%), Positives = 302/614 (49%), Gaps = 45/614 (7%)

Query: 44  SYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRL 103
           SYSV     PWW     R++  + +LK +S    SG+++ I+G SG+GK+TL++ ++G  
Sbjct: 80  SYSVPEG--PWW-----RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGY- 131

Query: 104 GRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS 163
            R     G V +NG       F+    Y++Q D LL  LTV+E +  +A L ++  + G 
Sbjct: 132 -RETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR 190

Query: 164 FQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGL 223
            ++ V+ ++  L L   A     N   G +S G+R+R++IA +L+ +P VM FDEPT+GL
Sbjct: 191 -REMVKEILTALGLLSCA-----NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 244

Query: 224 DCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDF 283
           D  +  Q+V L+  LA+  R ++ TIHQP ++LF+LFD++ +LS G+ ++ G    ++ +
Sbjct: 245 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPY 304

Query: 284 FNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSA---------I 334
             D G  CP + NP DF M++ S +   +   +  + R  M +S +K+           +
Sbjct: 305 LRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFL 364

Query: 335 CHK-TLKNIERMKHLKTLPMVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQN 393
            H+ + ++   M+   +          S    ++  +L +R   +++R+ +    R+  +
Sbjct: 365 WHRPSEEDSSSMEGCHSF---------SASCLTQFCILFKRTFLSIMRDSVLTHLRITSH 415

Query: 394 LIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQES 453
           + +GL +    L + +   K  +    G L+  +    +  ++  V  FP+   V  +E 
Sbjct: 416 IGIGLLIGLLYLGIGNEAKK--VLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREH 473

Query: 454 QDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIG 513
            +  Y      LA  +  +PF ++  + + S+ YW      +  RF  F+A      L+ 
Sbjct: 474 LNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVA 533

Query: 514 EFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSE 573
           + L L L+G       V + V  ++   VL+ SGF  +   +P   + +SY ++ +Y  E
Sbjct: 534 QSLGL-LIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFE 592

Query: 574 ILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSRFTMNFLILYSFIPA 633
            ++++  YGL+      ++    +  C F Q  + I +      ++  ++F++L  F  +
Sbjct: 593 GVILS-IYGLD----REDLHCDIDETCHF-QKSEAILRELDVENAKLYLDFIVLGIFFIS 646

Query: 634 LVILGIVV--FKIR 645
           L ++   V  +KIR
Sbjct: 647 LRLIAYFVLRYKIR 660


>gi|46592971 ATP-binding cassette sub-family G member 1 isoform 6
           [Homo sapiens]
          Length = 644

 Score =  209 bits (533), Expect = 5e-54
 Identities = 160/614 (26%), Positives = 302/614 (49%), Gaps = 45/614 (7%)

Query: 44  SYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRL 103
           SYSV     PWW     R++  + +LK +S    SG+++ I+G SG+GK+TL++ ++G  
Sbjct: 61  SYSVPEG--PWW-----RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGY- 112

Query: 104 GRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS 163
            R     G V +NG       F+    Y++Q D LL  LTV+E +  +A L ++  + G 
Sbjct: 113 -RETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR 171

Query: 164 FQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGL 223
            ++ V+ ++  L L   A     N   G +S G+R+R++IA +L+ +P VM FDEPT+GL
Sbjct: 172 -REMVKEILTALGLLSCA-----NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 225

Query: 224 DCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDF 283
           D  +  Q+V L+  LA+  R ++ TIHQP ++LF+LFD++ +LS G+ ++ G    ++ +
Sbjct: 226 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPY 285

Query: 284 FNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSA---------I 334
             D G  CP + NP DF M++ S +   +   +  + R  M +S +K+           +
Sbjct: 286 LRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFL 345

Query: 335 CHK-TLKNIERMKHLKTLPMVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQN 393
            H+ + ++   M+   +          S    ++  +L +R   +++R+ +    R+  +
Sbjct: 346 WHRPSEEDSSSMEGCHSF---------SASCLTQFCILFKRTFLSIMRDSVLTHLRITSH 396

Query: 394 LIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQES 453
           + +GL +    L + +   K  +    G L+  +    +  ++  V  FP+   V  +E 
Sbjct: 397 IGIGLLIGLLYLGIGNEAKK--VLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREH 454

Query: 454 QDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIG 513
            +  Y      LA  +  +PF ++  + + S+ YW      +  RF  F+A      L+ 
Sbjct: 455 LNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVA 514

Query: 514 EFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSE 573
           + L L L+G       V + V  ++   VL+ SGF  +   +P   + +SY ++ +Y  E
Sbjct: 515 QSLGL-LIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFE 573

Query: 574 ILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSRFTMNFLILYSFIPA 633
            ++++  YGL+      ++    +  C F Q  + I +      ++  ++F++L  F  +
Sbjct: 574 GVILS-IYGLD----REDLHCDIDETCHF-QKSEAILRELDVENAKLYLDFIVLGIFFIS 627

Query: 634 LVILGIVV--FKIR 645
           L ++   V  +KIR
Sbjct: 628 LRLIAYFVLRYKIR 641


>gi|46592964 ATP-binding cassette sub-family G member 1 isoform 5
           [Homo sapiens]
          Length = 668

 Score =  209 bits (533), Expect = 5e-54
 Identities = 160/614 (26%), Positives = 302/614 (49%), Gaps = 45/614 (7%)

Query: 44  SYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRL 103
           SYSV     PWW     R++  + +LK +S    SG+++ I+G SG+GK+TL++ ++G  
Sbjct: 85  SYSVPEG--PWW-----RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGY- 136

Query: 104 GRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS 163
            R     G V +NG       F+    Y++Q D LL  LTV+E +  +A L ++  + G 
Sbjct: 137 -RETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR 195

Query: 164 FQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGL 223
            ++ V+ ++  L L   A     N   G +S G+R+R++IA +L+ +P VM FDEPT+GL
Sbjct: 196 -REMVKEILTALGLLSCA-----NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 249

Query: 224 DCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDF 283
           D  +  Q+V L+  LA+  R ++ TIHQP ++LF+LFD++ +LS G+ ++ G    ++ +
Sbjct: 250 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPY 309

Query: 284 FNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSA---------I 334
             D G  CP + NP DF M++ S +   +   +  + R  M +S +K+           +
Sbjct: 310 LRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFL 369

Query: 335 CHK-TLKNIERMKHLKTLPMVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQN 393
            H+ + ++   M+   +          S    ++  +L +R   +++R+ +    R+  +
Sbjct: 370 WHRPSEEDSSSMEGCHSF---------SASCLTQFCILFKRTFLSIMRDSVLTHLRITSH 420

Query: 394 LIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQES 453
           + +GL +    L + +   K  +    G L+  +    +  ++  V  FP+   V  +E 
Sbjct: 421 IGIGLLIGLLYLGIGNEAKK--VLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREH 478

Query: 454 QDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIG 513
            +  Y      LA  +  +PF ++  + + S+ YW      +  RF  F+A      L+ 
Sbjct: 479 LNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVA 538

Query: 514 EFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSE 573
           + L L L+G       V + V  ++   VL+ SGF  +   +P   + +SY ++ +Y  E
Sbjct: 539 QSLGL-LIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFE 597

Query: 574 ILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSRFTMNFLILYSFIPA 633
            ++++  YGL+      ++    +  C F Q  + I +      ++  ++F++L  F  +
Sbjct: 598 GVILS-IYGLD----REDLHCDIDETCHF-QKSEAILRELDVENAKLYLDFIVLGIFFIS 651

Query: 634 LVILGIVV--FKIR 645
           L ++   V  +KIR
Sbjct: 652 LRLIAYFVLRYKIR 665


>gi|46592956 ATP-binding cassette sub-family G member 1 isoform 3
           [Homo sapiens]
          Length = 677

 Score =  209 bits (533), Expect = 5e-54
 Identities = 160/614 (26%), Positives = 302/614 (49%), Gaps = 45/614 (7%)

Query: 44  SYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRL 103
           SYSV     PWW     R++  + +LK +S    SG+++ I+G SG+GK+TL++ ++G  
Sbjct: 94  SYSVPEG--PWW-----RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGY- 145

Query: 104 GRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS 163
            R     G V +NG       F+    Y++Q D LL  LTV+E +  +A L ++  + G 
Sbjct: 146 -RETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR 204

Query: 164 FQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGL 223
            ++ V+ ++  L L   A     N   G +S G+R+R++IA +L+ +P VM FDEPT+GL
Sbjct: 205 -REMVKEILTALGLLSCA-----NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 258

Query: 224 DCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDF 283
           D  +  Q+V L+  LA+  R ++ TIHQP ++LF+LFD++ +LS G+ ++ G    ++ +
Sbjct: 259 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPY 318

Query: 284 FNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSA---------I 334
             D G  CP + NP DF M++ S +   +   +  + R  M +S +K+           +
Sbjct: 319 LRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFL 378

Query: 335 CHK-TLKNIERMKHLKTLPMVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQN 393
            H+ + ++   M+   +          S    ++  +L +R   +++R+ +    R+  +
Sbjct: 379 WHRPSEEDSSSMEGCHSF---------SASCLTQFCILFKRTFLSIMRDSVLTHLRITSH 429

Query: 394 LIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQES 453
           + +GL +    L + +   K  +    G L+  +    +  ++  V  FP+   V  +E 
Sbjct: 430 IGIGLLIGLLYLGIGNEAKK--VLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREH 487

Query: 454 QDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIG 513
            +  Y      LA  +  +PF ++  + + S+ YW      +  RF  F+A      L+ 
Sbjct: 488 LNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVA 547

Query: 514 EFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSE 573
           + L L L+G       V + V  ++   VL+ SGF  +   +P   + +SY ++ +Y  E
Sbjct: 548 QSLGL-LIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFE 606

Query: 574 ILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSRFTMNFLILYSFIPA 633
            ++++  YGL+      ++    +  C F Q  + I +      ++  ++F++L  F  +
Sbjct: 607 GVILS-IYGLD----REDLHCDIDETCHF-QKSEAILRELDVENAKLYLDFIVLGIFFIS 660

Query: 634 LVILGIVV--FKIR 645
           L ++   V  +KIR
Sbjct: 661 LRLIAYFVLRYKIR 674


>gi|46592898 ATP-binding cassette sub-family G member 1 isoform 2
           [Homo sapiens]
          Length = 666

 Score =  209 bits (533), Expect = 5e-54
 Identities = 160/614 (26%), Positives = 302/614 (49%), Gaps = 45/614 (7%)

Query: 44  SYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRL 103
           SYSV     PWW     R++  + +LK +S    SG+++ I+G SG+GK+TL++ ++G  
Sbjct: 83  SYSVPEG--PWW-----RKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGY- 134

Query: 104 GRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS 163
            R     G V +NG       F+    Y++Q D LL  LTV+E +  +A L ++  + G 
Sbjct: 135 -RETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGR 193

Query: 164 FQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGL 223
            ++ V+ ++  L L   A     N   G +S G+R+R++IA +L+ +P VM FDEPT+GL
Sbjct: 194 -REMVKEILTALGLLSCA-----NTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGL 247

Query: 224 DCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDF 283
           D  +  Q+V L+  LA+  R ++ TIHQP ++LF+LFD++ +LS G+ ++ G    ++ +
Sbjct: 248 DSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPY 307

Query: 284 FNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSA---------I 334
             D G  CP + NP DF M++ S +   +   +  + R  M +S +K+           +
Sbjct: 308 LRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFL 367

Query: 335 CHK-TLKNIERMKHLKTLPMVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQN 393
            H+ + ++   M+   +          S    ++  +L +R   +++R+ +    R+  +
Sbjct: 368 WHRPSEEDSSSMEGCHSF---------SASCLTQFCILFKRTFLSIMRDSVLTHLRITSH 418

Query: 394 LIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQES 453
           + +GL +    L + +   K  +    G L+  +    +  ++  V  FP+   V  +E 
Sbjct: 419 IGIGLLIGLLYLGIGNEAKK--VLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREH 476

Query: 454 QDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIG 513
            +  Y      LA  +  +PF ++  + + S+ YW      +  RF  F+A      L+ 
Sbjct: 477 LNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVA 536

Query: 514 EFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSE 573
           + L L L+G       V + V  ++   VL+ SGF  +   +P   + +SY ++ +Y  E
Sbjct: 537 QSLGL-LIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFE 595

Query: 574 ILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSRFTMNFLILYSFIPA 633
            ++++  YGL+      ++    +  C F Q  + I +      ++  ++F++L  F  +
Sbjct: 596 GVILS-IYGLD----REDLHCDIDETCHF-QKSEAILRELDVENAKLYLDFIVLGIFFIS 649

Query: 634 LVILGIVV--FKIR 645
           L ++   V  +KIR
Sbjct: 650 LRLIAYFVLRYKIR 663


>gi|116734710 ATP-binding cassette, sub-family A member 3 [Homo
           sapiens]
          Length = 1704

 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 73/213 (34%), Positives = 112/213 (52%), Gaps = 14/213 (6%)

Query: 66  RQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQF 125
           R  ++D++L +  GQI  +LG +G+GKTT L  ++G         G  Y++G  + ++  
Sbjct: 546 RAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTS---GRAYISGYEISQDMV 602

Query: 126 QDCFSYVL--QSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADR 183
           Q   S  L  Q D L  +LTV E L++ A L        S QK  E V   L +  + D+
Sbjct: 603 QIRKSLGLCPQHDILFDNLTVAEHLYFYAQL-----KGLSRQKCPEEVKQMLHIIGLEDK 657

Query: 184 LIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNR 243
              N     +S G RR++SI   L+   KV++ DEPT+G+D ++   I  LL +  + +R
Sbjct: 658 W--NSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLL-QRQKSDR 714

Query: 244 IVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
            +VLT H    E   L D+IAI++ GEL  CG+
Sbjct: 715 TIVLTTHF-MDEADLLGDRIAIMAKGELQCCGS 746



 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 60/221 (27%), Positives = 102/221 (46%), Gaps = 16/221 (7%)

Query: 72   VSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQDCF 129
            +SL V+ G+   +LG +G+GKTT    ++G         G+ +V G  +  +  + +   
Sbjct: 1402 LSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTS---GDAFVGGHRISSDVGKVRQRI 1458

Query: 130  SYVLQSDTLLSSLTVRETL-HYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNY 188
             Y  Q D LL  +T RE L  Y  L  I   + G+    VE  +  L L   A++L+  Y
Sbjct: 1459 GYCPQFDALLDHMTGREMLVMYARLRGIPERHIGAC---VENTLRGLLLEPHANKLVRTY 1515

Query: 189  SLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLT 248
            S      G +R++S    L+ +P V+  DEP+TG+D +    +   +       + +++T
Sbjct: 1516 S-----GGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIIT 1570

Query: 249  IHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
             H    E   L  ++AI+  G+    G+P  +   F   GY
Sbjct: 1571 SHS-MEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGS-GY 1609


>gi|45446740 ATP-binding cassette, sub-family A, member 2 isoform a
            [Homo sapiens]
          Length = 2436

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 72/219 (32%), Positives = 107/219 (48%), Gaps = 16/219 (7%)

Query: 74   LYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQDCFSY 131
            L V  G+   +LG +G+GKT+    ++G     G   GE +VNG ++ +E  Q Q    Y
Sbjct: 2076 LGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTG---GEAFVNGHSVLKELLQVQQSLGY 2132

Query: 132  VLQSDTLLSSLTVRETLH-YTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYSL 190
              Q D L   LT RE L  YT L  I   +     + V+  + +L L+  AD+  G YS 
Sbjct: 2133 CPQCDALFDELTAREHLQLYTRLRGISWKDEA---RVVKWALEKLELTKYADKPAGTYS- 2188

Query: 191  GGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIH 250
                 G +R++S A  L+  P  +  DEPTTG+D      +  L+++L +  R VVLT H
Sbjct: 2189 ----GGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2244

Query: 251  QPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
                E   L  ++AI+  G L   G+   + + F D GY
Sbjct: 2245 S-MEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGD-GY 2281



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 59/223 (26%), Positives = 108/223 (48%), Gaps = 15/223 (6%)

Query: 69   LKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQ 126
            L  +SL +   Q++  LG +G+GKTT +  ++G         G   + G  +R E  + +
Sbjct: 1008 LNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTS---GSATIYGHDIRTEMDEIR 1064

Query: 127  DCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIG 186
                   Q + L   LTV E L + + L          +++++ ++ +L LS+    L+ 
Sbjct: 1065 KNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQE--EIRREMDKMIEDLELSNKRHSLVQ 1122

Query: 187  NYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVV 246
                  +S G +R++S+A   +   + ++ DEPT G+D      I  L+++      I++
Sbjct: 1123 T-----LSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILL 1177

Query: 247  LTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
             T H   ++L  L D+IAI+S G+L  CG+P  +   + D GY
Sbjct: 1178 STHHMDEADL--LGDRIAIISHGKLKCCGSPLFLKGTYGD-GY 1217


>gi|47078218 ATP-binding cassette, sub-family A, member 2 isoform b
            [Homo sapiens]
          Length = 2466

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 72/219 (32%), Positives = 107/219 (48%), Gaps = 16/219 (7%)

Query: 74   LYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQDCFSY 131
            L V  G+   +LG +G+GKT+    ++G     G   GE +VNG ++ +E  Q Q    Y
Sbjct: 2106 LGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTG---GEAFVNGHSVLKELLQVQQSLGY 2162

Query: 132  VLQSDTLLSSLTVRETLH-YTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYSL 190
              Q D L   LT RE L  YT L  I   +     + V+  + +L L+  AD+  G YS 
Sbjct: 2163 CPQCDALFDELTAREHLQLYTRLRGISWKDEA---RVVKWALEKLELTKYADKPAGTYS- 2218

Query: 191  GGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIH 250
                 G +R++S A  L+  P  +  DEPTTG+D      +  L+++L +  R VVLT H
Sbjct: 2219 ----GGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKTGRSVVLTSH 2274

Query: 251  QPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
                E   L  ++AI+  G L   G+   + + F D GY
Sbjct: 2275 S-MEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGD-GY 2311



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 59/223 (26%), Positives = 108/223 (48%), Gaps = 15/223 (6%)

Query: 69   LKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQ 126
            L  +SL +   Q++  LG +G+GKTT +  ++G         G   + G  +R E  + +
Sbjct: 1038 LNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTS---GSATIYGHDIRTEMDEIR 1094

Query: 127  DCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIG 186
                   Q + L   LTV E L + + L          +++++ ++ +L LS+    L+ 
Sbjct: 1095 KNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQE--EIRREMDKMIEDLELSNKRHSLVQ 1152

Query: 187  NYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVV 246
                  +S G +R++S+A   +   + ++ DEPT G+D      I  L+++      I++
Sbjct: 1153 T-----LSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILL 1207

Query: 247  LTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
             T H   ++L  L D+IAI+S G+L  CG+P  +   + D GY
Sbjct: 1208 STHHMDEADL--LGDRIAIISHGKLKCCGSPLFLKGTYGD-GY 1247


>gi|27477115 ATP-binding cassette, sub-family A, member 9 [Homo
           sapiens]
          Length = 1624

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 70/214 (32%), Positives = 109/214 (50%), Gaps = 16/214 (7%)

Query: 67  QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRR---- 122
           + LK V   +  GQI  +LG SG+GKTTLL+ +SG         G V V    L R    
Sbjct: 498 EALKGVVFDIYEGQITALLGHSGAGKTTLLNILSGLSVPTS---GSVTVYNHTLSRMADI 554

Query: 123 EQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVAD 182
           E       +  QS+     LTV+E L   A   I+   P   +K+V+ V+ EL + ++ D
Sbjct: 555 ENISKFTGFCPQSNVQFGFLTVKENLRLFA--KIKGILPHEVEKEVQRVVQELEMENIQD 612

Query: 183 RLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRN 242
            L  N     +S G+ R+++    +L DP+V+L DEPT GLD ++ ++I  LL E  + +
Sbjct: 613 ILAQN-----LSGGQNRKLTFGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKE-GKSD 666

Query: 243 RIVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
           R+++ +  Q   E   L D+   +S G+L   G+
Sbjct: 667 RVILFST-QFIDEADILADRKVFISNGKLKCAGS 699



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 56/213 (26%), Positives = 102/213 (47%), Gaps = 24/213 (11%)

Query: 70   KDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCF 129
            ++VS  V+ G+++ +LG +G+GK+T +  ++G         G+V + G      +     
Sbjct: 1310 RNVSFCVKKGEVIGLLGHNGAGKSTTIKMITGDTKPTA---GQVILKGSG--GGEPLGFL 1364

Query: 130  SYVLQSDTLLSSLTVRETLH-YTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNY 188
             Y  Q + L  +LTVR+ L  Y A+  +R+G+            A ++++ + D L    
Sbjct: 1365 GYCPQENALWPNLTVRQHLEVYAAVKGLRKGD------------AMIAITRLVDALKLQD 1412

Query: 189  SLGG----ISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQI-VVLLVELARRNR 243
             L      +S G +R++     +L +P V+L DEP+TG+D     Q+  V+        R
Sbjct: 1413 QLKAPVKTLSEGIKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQVIRATFRNTER 1472

Query: 244  IVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
              +LT H   +E   + D++AI+  G L   G+
Sbjct: 1473 GALLTTHY-MAEAEAVCDRVAIMVSGRLRCIGS 1504


>gi|27881501 ATP-binding cassette, sub-family A, member 12 isoform b
            [Homo sapiens]
          Length = 2277

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 61/222 (27%), Positives = 111/222 (50%), Gaps = 15/222 (6%)

Query: 71   DVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQDC 128
            +++L    G I  +LG +G+GKTT +  ++G  G +    G ++V G+ ++ +    +  
Sbjct: 1045 NLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASA---GTIFVYGKDIKTDLHTVRKN 1101

Query: 129  FSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSL-SHVADRLIGN 187
                +Q D L S LT +E L     + +         ++V+  + +  L SH   R+   
Sbjct: 1102 MGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRV--- 1158

Query: 188  YSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVL 247
               G +S G +R++SI+  L+   +V++ DEP+TG+D  +   I  ++ +      I++ 
Sbjct: 1159 ---GTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILS 1215

Query: 248  TIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
            T H   +E+  L D+IA L  G L  CG+P  + + F D GY
Sbjct: 1216 THHLDEAEV--LSDRIAFLEQGGLRCCGSPFYLKEAFGD-GY 1254



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 51/209 (24%), Positives = 97/209 (46%), Gaps = 10/209 (4%)

Query: 69   LKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDC 128
            + ++S+ + +G+   +LG +G+GKTT+   ++G +  +   +      G     +     
Sbjct: 1955 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSL 2014

Query: 129  FSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS-FQKKVEAVMAELSLSHVADRLIGN 187
              Y  Q D L   +TV E L++ A +    G P    ++ V  ++  L L    DR    
Sbjct: 2015 VGYCPQEDALDDLVTVEEHLYFYARV---HGIPEKDIKETVHKLLRRLHLMPFKDR---- 2067

Query: 188  YSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVL 247
             +    S G +R++S A  L+  P ++L DEP++G+D  +   +  ++ E  +    V+L
Sbjct: 2068 -ATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVIL 2126

Query: 248  TIHQPRSELFQLFDKIAILSFGELIFCGT 276
            T H    E   L  ++AI+  G+    G+
Sbjct: 2127 TSHS-MEECEALCTRLAIMVNGKFQCIGS 2154



 Score = 30.8 bits (68), Expect = 4.1
 Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 2/70 (2%)

Query: 175  LSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVL 234
            +SL H+  + IGN +  GIST +   VS +    +D K++   E   G   +    + +L
Sbjct: 1356 MSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAIL 1415

Query: 235  LVEL--ARRN 242
            +      RRN
Sbjct: 1416 IKRFHHTRRN 1425


>gi|30795238 ATP-binding cassette, sub-family A, member 12 isoform a
            [Homo sapiens]
          Length = 2595

 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 61/222 (27%), Positives = 111/222 (50%), Gaps = 15/222 (6%)

Query: 71   DVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQDC 128
            +++L    G I  +LG +G+GKTT +  ++G  G +    G ++V G+ ++ +    +  
Sbjct: 1363 NLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASA---GTIFVYGKDIKTDLHTVRKN 1419

Query: 129  FSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSL-SHVADRLIGN 187
                +Q D L S LT +E L     + +         ++V+  + +  L SH   R+   
Sbjct: 1420 MGVCMQHDVLFSYLTTKEHLLLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRV--- 1476

Query: 188  YSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVL 247
               G +S G +R++SI+  L+   +V++ DEP+TG+D  +   I  ++ +      I++ 
Sbjct: 1477 ---GTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISKNKTARTIILS 1533

Query: 248  TIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
            T H   +E+  L D+IA L  G L  CG+P  + + F D GY
Sbjct: 1534 THHLDEAEV--LSDRIAFLEQGGLRCCGSPFYLKEAFGD-GY 1572



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 51/209 (24%), Positives = 97/209 (46%), Gaps = 10/209 (4%)

Query: 69   LKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDC 128
            + ++S+ + +G+   +LG +G+GKTT+   ++G +  +   +      G     +     
Sbjct: 2273 VNNISIGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKTGSLGHVDSHSSL 2332

Query: 129  FSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS-FQKKVEAVMAELSLSHVADRLIGN 187
              Y  Q D L   +TV E L++ A +    G P    ++ V  ++  L L    DR    
Sbjct: 2333 VGYCPQEDALDDLVTVEEHLYFYARV---HGIPEKDIKETVHKLLRRLHLMPFKDR---- 2385

Query: 188  YSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVL 247
             +    S G +R++S A  L+  P ++L DEP++G+D  +   +  ++ E  +    V+L
Sbjct: 2386 -ATSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWKIISEEVQNKCSVIL 2444

Query: 248  TIHQPRSELFQLFDKIAILSFGELIFCGT 276
            T H    E   L  ++AI+  G+    G+
Sbjct: 2445 TSHS-MEECEALCTRLAIMVNGKFQCIGS 2472



 Score = 30.8 bits (68), Expect = 4.1
 Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 2/70 (2%)

Query: 175  LSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVL 234
            +SL H+  + IGN +  GIST +   VS +    +D K++   E   G   +    + +L
Sbjct: 1674 MSLEHLTQKKIGNSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAIL 1733

Query: 235  LVEL--ARRN 242
            +      RRN
Sbjct: 1734 IKRFHHTRRN 1743


>gi|27436953 ATP-binding cassette, sub-family A, member 6 [Homo
           sapiens]
          Length = 1617

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 64/214 (29%), Positives = 109/214 (50%), Gaps = 16/214 (7%)

Query: 67  QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRR---- 122
           + LK +   +  GQI  ILG SG+GK++LL+ ++G    +    G V +  + L      
Sbjct: 495 EALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGL---SVPTEGSVTIYNKNLSEMQDL 551

Query: 123 EQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVAD 182
           E+ +       Q +     LTV+E L   A   I+  +    +++V+ ++ EL + ++ D
Sbjct: 552 EEIRKITGVCPQFNVQFDILTVKENLSLFA--KIKGIHLKEVEQEVQRILLELDMQNIQD 609

Query: 183 RLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRN 242
            L  +     +S G++R+++    +L DP+++L DEPTTGLD  + +Q+  LL E  RR 
Sbjct: 610 NLAKH-----LSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRE--RRA 662

Query: 243 RIVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
             V+L   Q   E   L D+  I+S G L   G+
Sbjct: 663 DHVILFSTQSMDEADILADRKVIMSNGRLKCAGS 696



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 61/222 (27%), Positives = 109/222 (49%), Gaps = 21/222 (9%)

Query: 59   SCRQQWTRQIL-KDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNG 117
            SC  +  ++I  +++S  V+ G+I+ +LG +G+GK++ +  +SG         GEV + G
Sbjct: 1292 SCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTA---GEVELKG 1348

Query: 118  RALRREQFQDCFSYVLQSDTLLSSLTVRETLH-YTALLAIRRGNPGSFQKKVEAVMAELS 176
             +           Y  Q + L   LT+RE L  Y A+  +R+ +         A+   +S
Sbjct: 1349 CS----SVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARL------AIARLVS 1398

Query: 177  LSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLV 236
               + ++L  N  +  ++ G  R++     LL +  V+L DEP+TG+D  T  Q +   +
Sbjct: 1399 AFKLHEQL--NVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGID-PTGQQQMWQAI 1455

Query: 237  ELARRN--RIVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
            +   +N  R V+LT H   +E   L D++AI+  G L   G+
Sbjct: 1456 QAVVKNTERGVLLTTHN-LAEAEALCDRVAIMVSGRLRCIGS 1496


>gi|105990541 ATP-binding cassette, sub-family A member 4 [Homo
            sapiens]
          Length = 2273

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 63/207 (30%), Positives = 102/207 (49%), Gaps = 14/207 (6%)

Query: 80   QIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRR--EQFQDCFSYVLQSDT 137
            QI   LG +G+GKTT L  ++G L       G V V GR +    +  +       Q + 
Sbjct: 957  QITAFLGHNGAGKTTTLSILTGLLPPTS---GTVLVGGRDIETSLDAVRQSLGMCPQHNI 1013

Query: 138  LLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYSLGGISTGE 197
            L   LTV E + + A L  +  +    Q ++EA++ +  L H       N     +S G 
Sbjct: 1014 LFHHLTVAEHMLFYAQL--KGKSQEEAQLEMEAMLEDTGLHHKR-----NEEAQDLSGGM 1066

Query: 198  RRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSELF 257
            +R++S+A   + D KV++ DEPT+G+D  +   I  LL++      I++ T H   ++L 
Sbjct: 1067 QRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKYRSGRTIIMSTHHMDEADL- 1125

Query: 258  QLFDKIAILSFGELIFCGTPAEMLDFF 284
             L D+IAI++ G L   GTP  + + F
Sbjct: 1126 -LGDRIAIIAQGRLYCSGTPLFLKNCF 1151



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 68/217 (31%), Positives = 99/217 (45%), Gaps = 16/217 (7%)

Query: 76   VESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE--QFQDCFSYVL 133
            V  G+   +LG +G+GKTT    ++G         G+  V G+++     +      Y  
Sbjct: 1962 VRPGECFGLLGVNGAGKTTTFKMLTGDTTVTS---GDATVAGKSILTNISEVHQNMGYCP 2018

Query: 134  QSDTLLSSLTVRETLHYTALLAIRRGNPGS-FQKKVEAVMAELSLSHVADRLIGNYSLGG 192
            Q D +   LT RE L+  A L   RG P    +K     +  L L+  AD L G YS   
Sbjct: 2019 QFDAIDELLTGREHLYLYARL---RGVPAEEIEKVANWSIKSLGLTVYADCLAGTYS--- 2072

Query: 193  ISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQP 252
               G +R++S A  L+  P ++L DEPTTG+D      +  ++V + R  R VVLT H  
Sbjct: 2073 --GGNKRKLSTAIALIGCPPLVLLDEPTTGMDPQARRMLWNVIVSIIREGRAVVLTSHS- 2129

Query: 253  RSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
              E   L  ++AI+  G     GT   +   F D GY
Sbjct: 2130 MEECEALCTRLAIMVKGAFRCMGTIQHLKSKFGD-GY 2165


>gi|150417984 ATP-binding cassette, sub-family A, member 7 [Homo
            sapiens]
          Length = 2146

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 68/210 (32%), Positives = 100/210 (47%), Gaps = 15/210 (7%)

Query: 74   LYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFS--Y 131
            L +  G+   +LG +G+GKT+    ++G    +    GE  + G ++ RE      S  Y
Sbjct: 1815 LGIPPGECFGLLGVNGAGKTSTFRMVTGDTLASR---GEAVLAGHSVAREPSAAHLSMGY 1871

Query: 132  VLQSDTLLSSLTVRETLHYTALLAIRRGNP-GSFQKKVEAVMAELSLSHVADRLIGNYSL 190
              QSD +   LT RE L    LLA  RG P     +   + +A L LS  ADR  G YS 
Sbjct: 1872 CPQSDAIFELLTGREHLE---LLARLRGVPEAQVAQTAGSGLARLGLSWYADRPAGTYS- 1927

Query: 191  GGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIH 250
                 G +R+++ A  L+ DP V+  DEPTTG+D      +   L+ + R  R V+LT H
Sbjct: 1928 ----GGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSH 1983

Query: 251  QPRSELFQLFDKIAILSFGELIFCGTPAEM 280
                E   L  ++AI+  G     G+P  +
Sbjct: 1984 S-MEECEALCSRLAIMVNGRFRCLGSPQHL 2012



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 59/212 (27%), Positives = 99/212 (46%), Gaps = 16/212 (7%)

Query: 69   LKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQ--FQ 126
            L+ +SL    G I   LG +G+GKTT L  +SG    +G   G  ++ G  +R      +
Sbjct: 824  LRGLSLDFYQGHITAFLGHNGAGKTTTLSILSGLFPPSG---GSAFILGHDVRSSMAAIR 880

Query: 127  DCFSYVLQSDTLLSSLTVRETL-HYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLI 185
                   Q + L   LTV E +  Y  L  +     G  Q ++   +  +S   V  R  
Sbjct: 881  PHLGVCPQYNVLFDMLTVDEHVWFYGRLKGLSAAVVGPEQDRLLQDVGLVSKQSVQTR-- 938

Query: 186  GNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIV 245
                   +S G +R++S+A   +   +V++ DEPT G+D  +   I  LL++      ++
Sbjct: 939  ------HLSGGMQRKLSVAIAFVGGSQVVILDEPTAGVDPASRRGIWELLLKYREGRTLI 992

Query: 246  VLTIHQPRSELFQLFDKIAILSFGELIFCGTP 277
            + T H   +EL  L D++A+++ G L  CG+P
Sbjct: 993  LSTHHLDEAEL--LGDRVAVVAGGRLCCCGSP 1022


>gi|31657092 ATP binding cassette, sub-family A (ABC1), member 13
            [Homo sapiens]
          Length = 5058

 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 55/214 (25%), Positives = 107/214 (50%), Gaps = 12/214 (5%)

Query: 66   RQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRRE-- 123
            + +++D+SL     QI  +LG++G+GKTT++  ++G         G + +NG+ L+ +  
Sbjct: 3855 KAVVQDLSLTFYRDQITALLGTNGAGKTTIISMLTGLHPPTS---GTIIINGKNLQTDLS 3911

Query: 124  QFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADR 183
            + +       Q D LL +LTVRE L   A +   +       ++V   + ++ L+    +
Sbjct: 3912 RVRMELGVCPQQDILLDNLTVREHLLLFASIKAPQWTKKELHQQVNQTLQDVDLTQHQHK 3971

Query: 184  LIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNR 243
                     +S G +R++S+    +   + ++ DEPT+G+D  + + +  +L++  R  R
Sbjct: 3972 -----QTRALSGGLKRKLSLGIAFMGMSRTVVLDEPTSGVDPCSRHSLWDILLKY-REGR 4025

Query: 244  IVVLTIHQPRSELFQLFDKIAILSFGELIFCGTP 277
             ++ T H    E   L D++A+L  G L  CG P
Sbjct: 4026 TIIFTTHH-LDEAEALSDRVAVLQHGRLRCCGPP 4058



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 63/234 (26%), Positives = 103/234 (44%), Gaps = 32/234 (13%)

Query: 69   LKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDC 128
            ++D+SL +  G+   +LG +G+GK+T    ++G +            +G A+ R    D 
Sbjct: 4737 VQDISLGIPKGECFGLLGVNGAGKSTTFKMLNGEVS---------LTSGHAIIRTPMGDA 4787

Query: 129  ------------FSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEA-VMAEL 175
                          Y  Q D L   LT  E L+Y   L   RG P     +V   ++  L
Sbjct: 4788 VDLSSAGTAGVLIGYCPQQDALDELLTGWEHLYYYCSL---RGIPRQCIPEVAGDLIRRL 4844

Query: 176  SLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLL 235
             L   AD+ +  YS      G +R++S A  L+  P ++L DEP++G+D  +   +   +
Sbjct: 4845 HLEAHADKPVATYS-----GGTKRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTI 4899

Query: 236  VELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
            ++  R     VLT H    E   L  ++AI+  G     G+P  + + F D GY
Sbjct: 4900 MKEVREGCAAVLTSHS-MEECEALCTRLAIMVNGSFKCLGSPQHIKNRFGD-GY 4951


>gi|27262624 ATP-binding cassette, sub-family A , member 5 [Homo
           sapiens]
          Length = 1642

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 62/213 (29%), Positives = 110/213 (51%), Gaps = 14/213 (6%)

Query: 67  QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQ 126
           + L+++S  +  GQI  +LG SG+GK+TL++ + G    +  F   +Y +  +   E F+
Sbjct: 495 EALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGF-ASIYGHRVSEIDEMFE 553

Query: 127 --DCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS-FQKKVEAVMAELSLSHVADR 183
                    Q D     LTV E L   ++LA  +G P +   ++V+ V+ +L +  + D 
Sbjct: 554 ARKMIGICPQLDIHFDVLTVEENL---SILASIKGIPANNIIQEVQKVLLDLDMQTIKDN 610

Query: 184 LIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNR 243
                    +S G++R++S+   +L +PK++L DEPT G+D   +  IV  L++  + NR
Sbjct: 611 QAKK-----LSGGQKRKLSLGIAVLGNPKILLLDEPTAGMD-PCSRHIVWNLLKYRKANR 664

Query: 244 IVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
           + V + H    E   L D+ A++S G L   G+
Sbjct: 665 VTVFSTHF-MDEADILADRKAVISQGMLKCVGS 696



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 50/211 (23%), Positives = 99/211 (46%), Gaps = 15/211 (7%)

Query: 70   KDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQD-- 127
            K +S  V+ G+I+ +LG +G+GK+T+++ + G +       G+V++   +    +  D  
Sbjct: 1317 KYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTS---GQVFLGDYSSETSEDDDSL 1373

Query: 128  -CFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIG 186
             C  Y  Q + L    T++E  H+    A++  +    ++ +  +   L L     + + 
Sbjct: 1374 KCMGYCPQINPLWPDTTLQE--HFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVK 1431

Query: 187  NYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQI-VVLLVELARRNRIV 245
                  +  G +R++  A  +L +P++ L DEP+TG+D      +   +      R R  
Sbjct: 1432 K-----LPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAA 1486

Query: 246  VLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
            +LT H    E   + D++AI+  G+L   GT
Sbjct: 1487 ILTTHY-MEEAEAVCDRVAIMVSGQLRCIGT 1516


>gi|27262626 ATP-binding cassette, sub-family A , member 5 [Homo
           sapiens]
          Length = 1642

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 62/213 (29%), Positives = 110/213 (51%), Gaps = 14/213 (6%)

Query: 67  QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQ 126
           + L+++S  +  GQI  +LG SG+GK+TL++ + G    +  F   +Y +  +   E F+
Sbjct: 495 EALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGF-ASIYGHRVSEIDEMFE 553

Query: 127 --DCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGS-FQKKVEAVMAELSLSHVADR 183
                    Q D     LTV E L   ++LA  +G P +   ++V+ V+ +L +  + D 
Sbjct: 554 ARKMIGICPQLDIHFDVLTVEENL---SILASIKGIPANNIIQEVQKVLLDLDMQTIKDN 610

Query: 184 LIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNR 243
                    +S G++R++S+   +L +PK++L DEPT G+D   +  IV  L++  + NR
Sbjct: 611 QAKK-----LSGGQKRKLSLGIAVLGNPKILLLDEPTAGMD-PCSRHIVWNLLKYRKANR 664

Query: 244 IVVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
           + V + H    E   L D+ A++S G L   G+
Sbjct: 665 VTVFSTHF-MDEADILADRKAVISQGMLKCVGS 696



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 50/211 (23%), Positives = 99/211 (46%), Gaps = 15/211 (7%)

Query: 70   KDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQD-- 127
            K +S  V+ G+I+ +LG +G+GK+T+++ + G +       G+V++   +    +  D  
Sbjct: 1317 KYISFCVKKGEILGLLGPNGAGKSTIINILVGDIEPTS---GQVFLGDYSSETSEDDDSL 1373

Query: 128  -CFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIG 186
             C  Y  Q + L    T++E  H+    A++  +    ++ +  +   L L     + + 
Sbjct: 1374 KCMGYCPQINPLWPDTTLQE--HFEIYGAVKGMSASDMKEVISRITHALDLKEHLQKTVK 1431

Query: 187  NYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQI-VVLLVELARRNRIV 245
                  +  G +R++  A  +L +P++ L DEP+TG+D      +   +      R R  
Sbjct: 1432 K-----LPAGIKRKLCFALSMLGNPQITLLDEPSTGMDPKAKQHMWRAIRTAFKNRKRAA 1486

Query: 246  VLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
            +LT H    E   + D++AI+  G+L   GT
Sbjct: 1487 ILTTHY-MEEAEAVCDRVAIMVSGQLRCIGT 1516


>gi|21536376 ATP-binding cassette, sub-family A member 1 [Homo
            sapiens]
          Length = 2261

 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 59/207 (28%), Positives = 100/207 (48%), Gaps = 13/207 (6%)

Query: 72   VSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQ--FQDCF 129
            ++L    GQI   LG +G+GKTT +  ++G         G  Y+ G+ +R E    +   
Sbjct: 919  LALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTS---GTAYILGKDIRSEMSTIRQNL 975

Query: 130  SYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYS 189
                Q + L   LTV E + + A L       G  +K V+A M +++L            
Sbjct: 976  GVCPQHNVLFDMLTVEEHIWFYARLK------GLSEKHVKAEMEQMALDVGLPSSKLKSK 1029

Query: 190  LGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTI 249
               +S G +R++S+A   +   KV++ DEPT G+D  +   I  LL++  +   I++ T 
Sbjct: 1030 TSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTH 1089

Query: 250  HQPRSELFQLFDKIAILSFGELIFCGT 276
            H   +++  L D+IAI+S G+L   G+
Sbjct: 1090 HMDEADV--LGDRIAIISHGKLCCVGS 1114



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 64/237 (27%), Positives = 107/237 (45%), Gaps = 16/237 (6%)

Query: 56   DITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSG--RLGRAGTFLGEV 113
            ++T   ++  +  +  + + +  G+   +LG +G+GK++    ++G   + R   FL + 
Sbjct: 1916 ELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNK- 1974

Query: 114  YVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKV-EAVM 172
              N       +      Y  Q D +   LT RE + + ALL   RG P     KV E  +
Sbjct: 1975 --NSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALL---RGVPEKEVGKVGEWAI 2029

Query: 173  AELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIV 232
             +L L    ++  GNYS      G +R++S A  L+  P V+  DEPTTG+D      + 
Sbjct: 2030 RKLGLVKYGEKYAGNYS-----GGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLW 2084

Query: 233  VLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGY 289
               + + +  R VVLT H    E   L  ++AI+  G     G+   + + F D GY
Sbjct: 2085 NCALSVVKEGRSVVLTSHS-MEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGD-GY 2139


>gi|153792144 ATP-binding cassette, sub-family A, member 10 [Homo
           sapiens]
          Length = 1543

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 60/212 (28%), Positives = 108/212 (50%), Gaps = 12/212 (5%)

Query: 67  QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVN--GRALRREQ 124
           + L+ +   +  GQI  ILG +G+GK+TLL+ +SG L  +      +Y          E+
Sbjct: 408 EALQGIFFDIYEGQITAILGHNGAGKSTLLNILSG-LSVSTEGSATIYNTQLSEITDMEE 466

Query: 125 FQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRL 184
            +    +  Q +     LTVRE L   A   I+   P   +++V+ ++ EL +  + D +
Sbjct: 467 IRKNIGFCPQFNFQFDFLTVRENLRVFA--KIKGIQPKEVEQEVKRIIMELDMQSIQDII 524

Query: 185 IGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRI 244
                   +S G++R++++   +L DP+V+L DEPT GLD  + +++  LL E  + +R+
Sbjct: 525 AKK-----LSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKE-HKVDRL 578

Query: 245 VVLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
           ++ +  Q   E   L D+   LS G+L   G+
Sbjct: 579 ILFST-QFMDEADILADRKVFLSNGKLKCAGS 609



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 71/271 (26%), Positives = 125/271 (46%), Gaps = 30/271 (11%)

Query: 15   LQVNRGSQSSLEGAPATAPEPH-SLGILHASYSVSHRVRPWWDITSCRQQWTRQI-LKDV 72
            +Q  R   ++   AP    EP  +   LH  Y  + +        SC     ++I +++V
Sbjct: 1174 VQAERVQAANALTAPNLEEEPVITASCLHKEYYETKK--------SCFSTRKKKIAIRNV 1225

Query: 73   SLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNG-RALRREQFQDCFS- 130
            S  V+ G+++ +LG +G+GK+T +  ++G         G V + G RA  R+Q  +    
Sbjct: 1226 SFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTA---GVVVLQGSRASVRQQHDNSLKF 1282

Query: 131  --YVLQSDTLLSSLTVRETLH-YTALLAIRRGNPG-SFQKKVEAVMAELSLSHVADRLIG 186
              Y  Q ++L   LT++E L  Y A+  + + +   S  + VEA+  +  L      L  
Sbjct: 1283 LGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPVKTL-- 1340

Query: 187  NYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQI-VVLLVELARRNRIV 245
                   S G +R++     +L +P V+L DEP TG+D     Q+  +L   +  + R  
Sbjct: 1341 -------SEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGT 1393

Query: 246  VLTIHQPRSELFQLFDKIAILSFGELIFCGT 276
            +LT H   SE   + D++A++  G L   G+
Sbjct: 1394 LLTTHY-MSEAEAVCDRMAMMVSGTLRCIGS 1423


>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
           sapiens]
          Length = 1280

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 66/262 (25%), Positives = 120/262 (45%), Gaps = 38/262 (14%)

Query: 67  QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALR--REQ 124
           +ILK ++L V+SGQ + ++G+SG GK+T +  M           G V V+G+ +R    +
Sbjct: 408 KILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTE---GMVSVDGQDIRTINVR 464

Query: 125 FQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAE-------LSL 177
           F      V+  + +L + T+ E + Y        G       ++E  + E       + L
Sbjct: 465 FLREIIGVVSQEPVLFATTIAENIRY--------GRENVTMDEIEKAVKEANAYDFIMKL 516

Query: 178 SHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVE 237
            H  D L+G      +S G+++R++IA  L+++PK++L DE T+ LD   +  +V + ++
Sbjct: 517 PHKFDTLVGERG-AQLSGGQKQRIAIARALVRNPKILLLDEATSALD-TESEAVVQVALD 574

Query: 238 LARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNP 297
            AR+ R  ++  H  R    +  D IA    G ++  G   E++                
Sbjct: 575 KARKGRTTIVIAH--RLSTVRNADVIAGFDDGVIVEKGNHDELM--------------KE 618

Query: 298 FDFYMDLTSVDTQSKEREIETS 319
              Y  L ++ T   E E+E +
Sbjct: 619 KGIYFKLVTMQTAGNEVELENA 640



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 55/224 (24%), Positives = 108/224 (48%), Gaps = 24/224 (10%)

Query: 68   ILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQD 127
            +L+ +SL V+ GQ + ++GSSG GK+T++  +           G+V ++G+ ++R   Q 
Sbjct: 1052 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFY---DPLAGKVLLDGKEIKRLNVQW 1108

Query: 128  CFSY--VLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMA--ELSLSHVADR 183
              ++  ++  + +L   ++ E + Y        G+      + E V A  E ++    + 
Sbjct: 1109 LRAHLGIVSQEPILFDCSIAENIAY--------GDNSRVVSQEEIVRAAKEANIHAFIES 1160

Query: 184  LIGNYSL------GGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVE 237
            L   YS         +S G+++R++IA  L++ P ++L DE T+ LD   + ++V   ++
Sbjct: 1161 LPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALD-TESEKVVQEALD 1219

Query: 238  LARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEML 281
             AR  R  ++  H  R    Q  D I +   G +   GT  ++L
Sbjct: 1220 KAREGRTCIVIAH--RLSTIQNADLIVVFQNGRVKEHGTHQQLL 1261


>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
           [Homo sapiens]
          Length = 1286

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 76/291 (26%), Positives = 134/291 (46%), Gaps = 42/291 (14%)

Query: 67  QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRR---E 123
           +ILK ++L V+SGQ + ++GSSG GK+T +  +  RL       G + ++G+ +R     
Sbjct: 410 KILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ-RLYDPDE--GTINIDGQDIRNFNVN 466

Query: 124 QFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQ-----KKVEAVMAELSLS 178
             ++    V Q   L S+ T+ E + Y       RGN    +     K+  A    + L 
Sbjct: 467 YLREIIGVVSQEPVLFST-TIAENICYG------RGNVTMDEIKKAVKEANAYEFIMKLP 519

Query: 179 HVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVEL 238
              D L+G      +S G+++R++IA  L+++PK++L DE T+ LD  +  ++   L + 
Sbjct: 520 QKFDTLVGERG-AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL-DK 577

Query: 239 ARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPF 298
           AR  R  ++  H  R    +  D IA    G ++  G+ +E++                 
Sbjct: 578 AREGRTTIVIAH--RLSTVRNADVIAGFEDGVIVEQGSHSELM--------------KKE 621

Query: 299 DFYMDLTSVDT-----QSKEREIETSK-RVQMIESAYKKSAICHKTLKNIE 343
             Y  L ++ T     QS+E E+   K   +M  + +K     H T KN++
Sbjct: 622 GVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLK 672



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 55/229 (24%), Positives = 108/229 (47%), Gaps = 27/229 (11%)

Query: 68   ILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGR-AGTFL---GEVYVNGRALRRE 123
            +L+ +SL V+ GQ + ++GSSG GK+T++  +       AGT     G   ++G+  ++ 
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKL 1110

Query: 124  QFQDCFSY--VLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELS----- 176
              Q   +   ++  + +L   ++ E + Y        G+      + E V A  +     
Sbjct: 1111 NVQWLRAQLGIVSQEPILFDCSIAENIAY--------GDNSRVVSQDEIVSAAKAANIHP 1162

Query: 177  ----LSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIV 232
                L H  +  +G+     +S G+++R++IA  L++ P+++L DE T+ LD   + ++V
Sbjct: 1163 FIETLPHKYETRVGDKGTQ-LSGGQKQRIAIARALIRQPQILLLDEATSALD-TESEKVV 1220

Query: 233  VLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEML 281
               ++ AR  R  ++  H  R    Q  D I +   G +   GT  ++L
Sbjct: 1221 QEALDKAREGRTCIVIAH--RLSTIQNADLIVVFQNGRVKEHGTHQQLL 1267


>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
           [Homo sapiens]
          Length = 1232

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 76/291 (26%), Positives = 134/291 (46%), Gaps = 42/291 (14%)

Query: 67  QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRR---E 123
           +ILK ++L V+SGQ + ++GSSG GK+T +  +  RL       G + ++G+ +R     
Sbjct: 410 KILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ-RLYDPDE--GTINIDGQDIRNFNVN 466

Query: 124 QFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQ-----KKVEAVMAELSLS 178
             ++    V Q   L S+ T+ E + Y       RGN    +     K+  A    + L 
Sbjct: 467 YLREIIGVVSQEPVLFST-TIAENICYG------RGNVTMDEIKKAVKEANAYEFIMKLP 519

Query: 179 HVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVEL 238
              D L+G      +S G+++R++IA  L+++PK++L DE T+ LD  +  ++   L + 
Sbjct: 520 QKFDTLVGERG-AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL-DK 577

Query: 239 ARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPF 298
           AR  R  ++  H  R    +  D IA    G ++  G+ +E++                 
Sbjct: 578 AREGRTTIVIAH--RLSTVRNADVIAGFEDGVIVEQGSHSELM--------------KKE 621

Query: 299 DFYMDLTSVDT-----QSKEREIETSK-RVQMIESAYKKSAICHKTLKNIE 343
             Y  L ++ T     QS+E E+   K   +M  + +K     H T KN++
Sbjct: 622 GVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLK 672



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 53/225 (23%), Positives = 106/225 (47%), Gaps = 26/225 (11%)

Query: 68   ILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQD 127
            +L+ +SL V+ GQ + ++GSSG GK+T++  +           G V ++G+  ++   Q 
Sbjct: 1004 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYD---PLAGTVLLDGQEAKKLNVQW 1060

Query: 128  CFSY--VLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELS--------- 176
              +   ++  + +L   ++ E + Y        G+      + E V A  +         
Sbjct: 1061 LRAQLGIVSQEPILFDCSIAENIAY--------GDNSRVVSQDEIVSAAKAANIHPFIET 1112

Query: 177  LSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLV 236
            L H  +  +G+     +S G+++R++IA  L++ P+++L DE T+ LD   + ++V   +
Sbjct: 1113 LPHKYETRVGDKGTQ-LSGGQKQRIAIARALIRQPQILLLDEATSALD-TESEKVVQEAL 1170

Query: 237  ELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEML 281
            + AR  R  ++  H  R    Q  D I +   G +   GT  ++L
Sbjct: 1171 DKAREGRTCIVIAH--RLSTIQNADLIVVFQNGRVKEHGTHQQLL 1213


>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
           [Homo sapiens]
          Length = 1279

 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 76/291 (26%), Positives = 134/291 (46%), Gaps = 42/291 (14%)

Query: 67  QILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRR---E 123
           +ILK ++L V+SGQ + ++GSSG GK+T +  +  RL       G + ++G+ +R     
Sbjct: 410 KILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQ-RLYDPDE--GTINIDGQDIRNFNVN 466

Query: 124 QFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQ-----KKVEAVMAELSLS 178
             ++    V Q   L S+ T+ E + Y       RGN    +     K+  A    + L 
Sbjct: 467 YLREIIGVVSQEPVLFST-TIAENICYG------RGNVTMDEIKKAVKEANAYEFIMKLP 519

Query: 179 HVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVEL 238
              D L+G      +S G+++R++IA  L+++PK++L DE T+ LD  +  ++   L + 
Sbjct: 520 QKFDTLVGERG-AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAAL-DK 577

Query: 239 ARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPF 298
           AR  R  ++  H  R    +  D IA    G ++  G+ +E++                 
Sbjct: 578 AREGRTTIVIAH--RLSTVRNADVIAGFEDGVIVEQGSHSELM--------------KKE 621

Query: 299 DFYMDLTSVDT-----QSKEREIETSK-RVQMIESAYKKSAICHKTLKNIE 343
             Y  L ++ T     QS+E E+   K   +M  + +K     H T KN++
Sbjct: 622 GVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLK 672



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 53/225 (23%), Positives = 106/225 (47%), Gaps = 26/225 (11%)

Query: 68   ILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQD 127
            +L+ +SL V+ GQ + ++GSSG GK+T++  +           G V ++G+  ++   Q 
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYD---PLAGTVLLDGQEAKKLNVQW 1107

Query: 128  CFSY--VLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELS--------- 176
              +   ++  + +L   ++ E + Y        G+      + E V A  +         
Sbjct: 1108 LRAQLGIVSQEPILFDCSIAENIAY--------GDNSRVVSQDEIVSAAKAANIHPFIET 1159

Query: 177  LSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLV 236
            L H  +  +G+     +S G+++R++IA  L++ P+++L DE T+ LD   + ++V   +
Sbjct: 1160 LPHKYETRVGDKGTQ-LSGGQKQRIAIARALIRQPQILLLDEATSALD-TESEKVVQEAL 1217

Query: 237  ELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEML 281
            + AR  R  ++  H  R    Q  D I +   G +   GT  ++L
Sbjct: 1218 DKAREGRTCIVIAH--RLSTIQNADLIVVFQNGRVKEHGTHQQLL 1260


>gi|90421313 cystic fibrosis transmembrane conductance regulator
           [Homo sapiens]
          Length = 1480

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 62/217 (28%), Positives = 107/217 (49%), Gaps = 27/217 (12%)

Query: 68  ILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQD 127
           +LKD++  +E GQ++ + GS+G+GKT+LL  + G L  +    G++  +GR      F  
Sbjct: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSE---GKIKHSGRI----SFCS 492

Query: 128 CFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGN 187
            FS+++         T++E + +       R     ++  ++A   E  +S  A++    
Sbjct: 493 QFSWIMPG-------TIKENIIFGVSYDEYR-----YRSVIKACQLEEDISKFAEKDNIV 540

Query: 188 YSLGGI--STGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLV--ELARRNR 243
              GGI  S G+R R+S+A  + +D  + L D P   LD +T  +I    V   +A + R
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600

Query: 244 IVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEM 280
           I+V +    + E  +  DKI IL  G   F GT +E+
Sbjct: 601 ILVTS----KMEHLKKADKILILHEGSSYFYGTFSEL 633



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 53/205 (25%), Positives = 98/205 (47%), Gaps = 24/205 (11%)

Query: 56   DITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYV 115
            D+T+   +    IL+++S  +  GQ + +LG +GSGK+TLL A    L       GE+ +
Sbjct: 1214 DLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTE----GEIQI 1269

Query: 116  NG---RALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVM 172
            +G    ++  +Q++  F  + Q   + S  T R+ L      +          +++  V 
Sbjct: 1270 DGVSWDSITLQQWRKAFGVIPQKVFIFSG-TFRKNLDPYEQWS---------DQEIWKVA 1319

Query: 173  AELSLSHVADRLIGNYSL----GG--ISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCM 226
             E+ L  V ++  G        GG  +S G ++ + +A  +L   K++L DEP+  LD +
Sbjct: 1320 DEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV 1379

Query: 227  TANQIVVLLVELARRNRIVVLTIHQ 251
            T  QI+   ++ A  +  V+L  H+
Sbjct: 1380 T-YQIIRRTLKQAFADCTVILCEHR 1403


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.139    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,362,358
Number of Sequences: 37866
Number of extensions: 937581
Number of successful extensions: 3237
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2956
Number of HSP's gapped (non-prelim): 168
length of query: 651
length of database: 18,247,518
effective HSP length: 109
effective length of query: 542
effective length of database: 14,120,124
effective search space: 7653107208
effective search space used: 7653107208
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.