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Search of human proteins with 118498343
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118498343 ATPase, Ca++ transporting, type 2C, member 2 [Homo
sapiens]
(946 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118498343 ATPase, Ca++ transporting, type 2C, member 2 [Homo ... 1838 0.0
gi|48762691 calcium-transporting ATPase 2C1 isoform 1b [Homo sap... 1179 0.0
gi|48762689 calcium-transporting ATPase 2C1 isoform 1d [Homo sap... 1179 0.0
gi|48762685 calcium-transporting ATPase 2C1 isoform 1a [Homo sap... 1179 0.0
gi|48762687 calcium-transporting ATPase 2C1 isoform 1c [Homo sap... 1152 0.0
gi|24638454 ATPase, Ca++ transporting, slow twitch 2 isoform 1 [... 443 e-124
gi|4502285 ATPase, Ca++ transporting, slow twitch 2 isoform 2 [H... 442 e-124
gi|10835220 ATPase, Ca++ transporting, fast twitch 1 isoform b [... 441 e-123
gi|27886529 ATPase, Ca++ transporting, fast twitch 1 isoform a [... 441 e-123
gi|28373103 ATPase, Ca++ transporting, ubiquitous isoform a [Hom... 438 e-122
gi|28373115 ATPase, Ca++ transporting, ubiquitous isoform c [Hom... 438 e-122
gi|28373113 ATPase, Ca++ transporting, ubiquitous isoform f [Hom... 438 e-122
gi|28373111 ATPase, Ca++ transporting, ubiquitous isoform c [Hom... 438 e-122
gi|28373109 ATPase, Ca++ transporting, ubiquitous isoform b [Hom... 438 e-122
gi|28373107 ATPase, Ca++ transporting, ubiquitous isoform d [Hom... 438 e-122
gi|28373105 ATPase, Ca++ transporting, ubiquitous isoform e [Hom... 438 e-122
gi|209413709 ATPase, Ca++ transporting, slow twitch 2 isoform 3 ... 404 e-112
gi|4502271 Na+/K+ -ATPase alpha 2 subunit proprotein [Homo sapiens] 361 2e-99
gi|237681109 Na+/K+ -ATPase alpha 1 subunit isoform c [Homo sapi... 354 2e-97
gi|21361181 Na+/K+ -ATPase alpha 1 subunit isoform a [Homo sapiens] 354 2e-97
gi|237681111 Na+/K+ -ATPase alpha 1 subunit isoform d [Homo sapi... 353 5e-97
gi|153946397 Na+/K+ -ATPase alpha 4 subunit isoform 1 [Homo sapi... 345 1e-94
gi|22748667 Na+/K+ -ATPase alpha 3 subunit [Homo sapiens] 343 4e-94
gi|51944966 hydrogen/potassium-exchanging ATPase 4A [Homo sapiens] 331 2e-90
gi|83700225 hydrogen/potassium-exchanging ATPase 12A [Homo sapiens] 324 2e-88
gi|48255949 plasma membrane calcium ATPase 2 isoform 2 [Homo sap... 283 7e-76
gi|48255951 plasma membrane calcium ATPase 2 isoform 1 [Homo sap... 256 9e-68
gi|48255947 plasma membrane calcium ATPase 1 isoform 1a [Homo sa... 248 2e-65
gi|48255945 plasma membrane calcium ATPase 1 isoform 1b [Homo sa... 248 2e-65
gi|48255959 plasma membrane calcium ATPase 4 isoform 4a [Homo sa... 243 6e-64
>gi|118498343 ATPase, Ca++ transporting, type 2C, member 2 [Homo
sapiens]
Length = 946
Score = 1838 bits (4760), Expect = 0.0
Identities = 946/946 (100%), Positives = 946/946 (100%)
Query: 1 MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKC 60
MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKC
Sbjct: 1 MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKC 60
Query: 61 QKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLG 120
QKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLG
Sbjct: 61 QKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLG 120
Query: 121 SALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPECNCLREGKLQH 180
SALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPECNCLREGKLQH
Sbjct: 121 SALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPECNCLREGKLQH 180
Query: 181 LLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLT 240
LLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLT
Sbjct: 181 LLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLT 240
Query: 241 TLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTL 300
TLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTL
Sbjct: 241 TLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTL 300
Query: 301 FSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVI 360
FSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVI
Sbjct: 301 FSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVI 360
Query: 361 VKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPS 420
VKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPS
Sbjct: 361 VKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPS 420
Query: 421 KEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKNSYIRK 480
KEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKNSYIRK
Sbjct: 421 KEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKNSYIRK 480
Query: 481 KEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFC 540
KEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFC
Sbjct: 481 KEIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFC 540
Query: 541 LQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMIT 600
LQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMIT
Sbjct: 541 LQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMIT 600
Query: 601 GDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIK 660
GDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIK
Sbjct: 601 GDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIK 660
Query: 661 ALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVE 720
ALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVE
Sbjct: 661 ALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVE 720
Query: 721 EGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLG 780
EGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLG
Sbjct: 721 EGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLG 780
Query: 781 VEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDRASTPRTTT 840
VEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDRASTPRTTT
Sbjct: 781 VEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGTLFIFWKEMPEDRASTPRTTT 840
Query: 841 MTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQ 900
MTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQ
Sbjct: 841 MTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQ 900
Query: 901 TENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV 946
TENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV
Sbjct: 901 TENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHPEDV 946
>gi|48762691 calcium-transporting ATPase 2C1 isoform 1b [Homo
sapiens]
Length = 939
Score = 1179 bits (3051), Expect = 0.0
Identities = 599/902 (66%), Positives = 728/902 (80%), Gaps = 9/902 (0%)
Query: 44 EKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVW 103
E E + L K+A + ++A DL GL++ V+ RR HGWNEF EP+W
Sbjct: 13 ENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLW 72
Query: 104 KKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELT 163
KKY+ QFKNPLI+LLL SA++SVL +++DAVSI A+L+VVTVAF+QEYRSEKSLEEL+
Sbjct: 73 KKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELS 132
Query: 164 KMVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEA 223
K+VPPEC+C+REGKL+H LAR+LVPGD V LS+GDR+PAD+RL E DL +DESS TGE
Sbjct: 133 KLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGET 192
Query: 224 EPCSKTDSPLTGG--GDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEE 281
PCSK +P GDL + SNI FMGTLV+ G+ +GVVIGTGE+S+FGEVFKMMQAEE
Sbjct: 193 TPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEE 252
Query: 282 TPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPI 341
PKTPLQKSMD LGKQL+ +SFGIIG+IML+GW GK +L MFTI VSLAVAAIPEGLPI
Sbjct: 253 APKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPI 312
Query: 342 VVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLR 401
VV VTL LGV+RM KKR IVKKLPIVETLGCC+V+CSDKTGTLT NEMTVT + TSDGL
Sbjct: 313 VVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLH 372
Query: 402 AEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGAL 461
AEV+GVGY+ G V + +V+ F N +V ++VEAGCV N+AVIR N +MG+PTEGAL
Sbjct: 373 AEVTGVGYNQFGEVIV--DGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGAL 430
Query: 462 MALAMKMDLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTE-DQEDIYFMKGALEEVIRYC 520
+ALAMKM L ++ YIRK E PFSSEQKWMAVKC +T+ D+ +I FMKGA E+VI+YC
Sbjct: 431 IALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYC 490
Query: 521 TMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRV 580
T Y + G L LT QQR QE+ RMGS GLRVLALASGPELG+LTFLGLVGIIDPPR
Sbjct: 491 TTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRT 550
Query: 581 GVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADR 640
GVKEAV L SGVS+KMITGD+ ETA+AI +GL + Q++SGEE+D+++ +L+
Sbjct: 551 GVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQI 610
Query: 641 VGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSK 700
V KV+VF+R SP+HK+KIIK+LQ++G++VAMTGDGVNDAVALK+ADIG+AMGQTGTDV K
Sbjct: 611 VPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCK 670
Query: 701 EAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLN 760
EAA+MILVDDDF IM+A+EEGKGI+ NIKNFVRFQLSTSI+AL+LI+L+T+ N P+PLN
Sbjct: 671 EAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLN 730
Query: 761 AMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGT 820
AMQILWINIIMDGPPAQSLGVEPVDKD R+PPR+ +D+IL++ LILKIL+S+ II+ GT
Sbjct: 731 AMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGT 790
Query: 821 LFIFWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVL 880
LF+FW+E+ D TPR TTMTFTCFVFFD+FNAL+ RSQTK +FEIG N MF Y+VL
Sbjct: 791 LFVFWREL-RDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVL 849
Query: 881 GSILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQ 940
GSI+GQL VIY PPLQ+VFQTE+L LDLLFL GL SSV I++E++K E+ S +++Q
Sbjct: 850 GSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVER---SREKIQ 906
Query: 941 MH 942
H
Sbjct: 907 KH 908
>gi|48762689 calcium-transporting ATPase 2C1 isoform 1d [Homo
sapiens]
Length = 949
Score = 1179 bits (3051), Expect = 0.0
Identities = 599/902 (66%), Positives = 728/902 (80%), Gaps = 9/902 (0%)
Query: 44 EKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVW 103
E E + L K+A + ++A DL GL++ V+ RR HGWNEF EP+W
Sbjct: 13 ENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLW 72
Query: 104 KKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELT 163
KKY+ QFKNPLI+LLL SA++SVL +++DAVSI A+L+VVTVAF+QEYRSEKSLEEL+
Sbjct: 73 KKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELS 132
Query: 164 KMVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEA 223
K+VPPEC+C+REGKL+H LAR+LVPGD V LS+GDR+PAD+RL E DL +DESS TGE
Sbjct: 133 KLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGET 192
Query: 224 EPCSKTDSPLTGG--GDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEE 281
PCSK +P GDL + SNI FMGTLV+ G+ +GVVIGTGE+S+FGEVFKMMQAEE
Sbjct: 193 TPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEE 252
Query: 282 TPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPI 341
PKTPLQKSMD LGKQL+ +SFGIIG+IML+GW GK +L MFTI VSLAVAAIPEGLPI
Sbjct: 253 APKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPI 312
Query: 342 VVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLR 401
VV VTL LGV+RM KKR IVKKLPIVETLGCC+V+CSDKTGTLT NEMTVT + TSDGL
Sbjct: 313 VVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLH 372
Query: 402 AEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGAL 461
AEV+GVGY+ G V + +V+ F N +V ++VEAGCV N+AVIR N +MG+PTEGAL
Sbjct: 373 AEVTGVGYNQFGEVIV--DGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGAL 430
Query: 462 MALAMKMDLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTE-DQEDIYFMKGALEEVIRYC 520
+ALAMKM L ++ YIRK E PFSSEQKWMAVKC +T+ D+ +I FMKGA E+VI+YC
Sbjct: 431 IALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYC 490
Query: 521 TMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRV 580
T Y + G L LT QQR QE+ RMGS GLRVLALASGPELG+LTFLGLVGIIDPPR
Sbjct: 491 TTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRT 550
Query: 581 GVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADR 640
GVKEAV L SGVS+KMITGD+ ETA+AI +GL + Q++SGEE+D+++ +L+
Sbjct: 551 GVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQI 610
Query: 641 VGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSK 700
V KV+VF+R SP+HK+KIIK+LQ++G++VAMTGDGVNDAVALK+ADIG+AMGQTGTDV K
Sbjct: 611 VPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCK 670
Query: 701 EAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLN 760
EAA+MILVDDDF IM+A+EEGKGI+ NIKNFVRFQLSTSI+AL+LI+L+T+ N P+PLN
Sbjct: 671 EAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLN 730
Query: 761 AMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGT 820
AMQILWINIIMDGPPAQSLGVEPVDKD R+PPR+ +D+IL++ LILKIL+S+ II+ GT
Sbjct: 731 AMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGT 790
Query: 821 LFIFWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVL 880
LF+FW+E+ D TPR TTMTFTCFVFFD+FNAL+ RSQTK +FEIG N MF Y+VL
Sbjct: 791 LFVFWREL-RDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVL 849
Query: 881 GSILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQ 940
GSI+GQL VIY PPLQ+VFQTE+L LDLLFL GL SSV I++E++K E+ S +++Q
Sbjct: 850 GSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVER---SREKIQ 906
Query: 941 MH 942
H
Sbjct: 907 KH 908
>gi|48762685 calcium-transporting ATPase 2C1 isoform 1a [Homo
sapiens]
Length = 919
Score = 1179 bits (3051), Expect = 0.0
Identities = 599/902 (66%), Positives = 728/902 (80%), Gaps = 9/902 (0%)
Query: 44 EKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVW 103
E E + L K+A + ++A DL GL++ V+ RR HGWNEF EP+W
Sbjct: 13 ENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLW 72
Query: 104 KKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELT 163
KKY+ QFKNPLI+LLL SA++SVL +++DAVSI A+L+VVTVAF+QEYRSEKSLEEL+
Sbjct: 73 KKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELS 132
Query: 164 KMVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEA 223
K+VPPEC+C+REGKL+H LAR+LVPGD V LS+GDR+PAD+RL E DL +DESS TGE
Sbjct: 133 KLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGET 192
Query: 224 EPCSKTDSPLTGG--GDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEE 281
PCSK +P GDL + SNI FMGTLV+ G+ +GVVIGTGE+S+FGEVFKMMQAEE
Sbjct: 193 TPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEE 252
Query: 282 TPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPI 341
PKTPLQKSMD LGKQL+ +SFGIIG+IML+GW GK +L MFTI VSLAVAAIPEGLPI
Sbjct: 253 APKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPI 312
Query: 342 VVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLR 401
VV VTL LGV+RM KKR IVKKLPIVETLGCC+V+CSDKTGTLT NEMTVT + TSDGL
Sbjct: 313 VVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLH 372
Query: 402 AEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGAL 461
AEV+GVGY+ G V + +V+ F N +V ++VEAGCV N+AVIR N +MG+PTEGAL
Sbjct: 373 AEVTGVGYNQFGEVIV--DGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGAL 430
Query: 462 MALAMKMDLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTE-DQEDIYFMKGALEEVIRYC 520
+ALAMKM L ++ YIRK E PFSSEQKWMAVKC +T+ D+ +I FMKGA E+VI+YC
Sbjct: 431 IALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYC 490
Query: 521 TMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRV 580
T Y + G L LT QQR QE+ RMGS GLRVLALASGPELG+LTFLGLVGIIDPPR
Sbjct: 491 TTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRT 550
Query: 581 GVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADR 640
GVKEAV L SGVS+KMITGD+ ETA+AI +GL + Q++SGEE+D+++ +L+
Sbjct: 551 GVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQI 610
Query: 641 VGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSK 700
V KV+VF+R SP+HK+KIIK+LQ++G++VAMTGDGVNDAVALK+ADIG+AMGQTGTDV K
Sbjct: 611 VPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCK 670
Query: 701 EAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLN 760
EAA+MILVDDDF IM+A+EEGKGI+ NIKNFVRFQLSTSI+AL+LI+L+T+ N P+PLN
Sbjct: 671 EAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLN 730
Query: 761 AMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGT 820
AMQILWINIIMDGPPAQSLGVEPVDKD R+PPR+ +D+IL++ LILKIL+S+ II+ GT
Sbjct: 731 AMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGT 790
Query: 821 LFIFWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVL 880
LF+FW+E+ D TPR TTMTFTCFVFFD+FNAL+ RSQTK +FEIG N MF Y+VL
Sbjct: 791 LFVFWREL-RDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVL 849
Query: 881 GSILGQLAVIYIPPLQRVFQTENLGALDLLFLTGLASSVFILSELLKLCEKYCCSPKRVQ 940
GSI+GQL VIY PPLQ+VFQTE+L LDLLFL GL SSV I++E++K E+ S +++Q
Sbjct: 850 GSIMGQLLVIYFPPLQKVFQTESLSILDLLFLLGLTSSVCIVAEIIKKVER---SREKIQ 906
Query: 941 MH 942
H
Sbjct: 907 KH 908
>gi|48762687 calcium-transporting ATPase 2C1 isoform 1c [Homo
sapiens]
Length = 888
Score = 1152 bits (2981), Expect = 0.0
Identities = 583/869 (67%), Positives = 704/869 (81%), Gaps = 6/869 (0%)
Query: 44 EKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVW 103
E E + L K+A + ++A DL GL++ V+ RR HGWNEF EP+W
Sbjct: 13 ENETMIPVLTSKKASELPVSEVASILQADLQNGLNKCEVSHRRAFHGWNEFDISEDEPLW 72
Query: 104 KKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELT 163
KKY+ QFKNPLI+LLL SA++SVL +++DAVSI A+L+VVTVAF+QEYRSEKSLEEL+
Sbjct: 73 KKYISQFKNPLIMLLLASAVISVLMHQFDDAVSITVAILIVVTVAFVQEYRSEKSLEELS 132
Query: 164 KMVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEA 223
K+VPPEC+C+REGKL+H LAR+LVPGD V LS+GDR+PAD+RL E DL +DESS TGE
Sbjct: 133 KLVPPECHCVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESSLTGET 192
Query: 224 EPCSKTDSPLTGG--GDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEE 281
PCSK +P GDL + SNI FMGTLV+ G+ +GVVIGTGE+S+FGEVFKMMQAEE
Sbjct: 193 TPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGVVIGTGENSEFGEVFKMMQAEE 252
Query: 282 TPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPI 341
PKTPLQKSMD LGKQL+ +SFGIIG+IML+GW GK +L MFTI VSLAVAAIPEGLPI
Sbjct: 253 APKTPLQKSMDLLGKQLSFYSFGIIGIIMLVGWLLGKDILEMFTISVSLAVAAIPEGLPI 312
Query: 342 VVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLR 401
VV VTL LGV+RM KKR IVKKLPIVETLGCC+V+CSDKTGTLT NEMTVT + TSDGL
Sbjct: 313 VVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLH 372
Query: 402 AEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGAL 461
AEV+GVGY+ G V + +V+ F N +V ++VEAGCV N+AVIR N +MG+PTEGAL
Sbjct: 373 AEVTGVGYNQFGEVIV--DGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNTLMGKPTEGAL 430
Query: 462 MALAMKMDLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTE-DQEDIYFMKGALEEVIRYC 520
+ALAMKM L ++ YIRK E PFSSEQKWMAVKC +T+ D+ +I FMKGA E+VI+YC
Sbjct: 431 IALAMKMGLDGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPEICFMKGAYEQVIKYC 490
Query: 521 TMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALASGPELGRLTFLGLVGIIDPPRV 580
T Y + G L LT QQR QE+ RMGS GLRVLALASGPELG+LTFLGLVGIIDPPR
Sbjct: 491 TTYQSKGQTLTLTQQQRDVYQQEKARMGSAGLRVLALASGPELGQLTFLGLVGIIDPPRT 550
Query: 581 GVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVDSVEKGELADR 640
GVKEAV L SGVS+KMITGD+ ETA+AI +GL + Q++SGEE+D+++ +L+
Sbjct: 551 GVKEAVTTLIASGVSIKMITGDSQETAVAIASRLGLYSKTSQSVSGEEIDAMDVQQLSQI 610
Query: 641 VGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSK 700
V KV+VF+R SP+HK+KIIK+LQ++G++VAMTGDGVNDAVALK+ADIG+AMGQTGTDV K
Sbjct: 611 VPKVAVFYRASPRHKMKIIKSLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCK 670
Query: 701 EAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLN 760
EAA+MILVDDDF IM+A+EEGKGI+ NIKNFVRFQLSTSI+AL+LI+L+T+ N P+PLN
Sbjct: 671 EAADMILVDDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLN 730
Query: 761 AMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGT 820
AMQILWINIIMDGPPAQSLGVEPVDKD R+PPR+ +D+IL++ LILKIL+S+ II+ GT
Sbjct: 731 AMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNWKDSILTKNLILKILVSSIIIVCGT 790
Query: 821 LFIFWKEMPEDRASTPRTTTMTFTCFVFFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVL 880
LF+FW+E+ D TPR TTMTFTCFVFFD+FNAL+ RSQTK +FEIG N MF Y+VL
Sbjct: 791 LFVFWREL-RDNVITPRDTTMTFTCFVFFDMFNALSSRSQTKSVFEIGLCSNRMFCYAVL 849
Query: 881 GSILGQLAVIYIPPLQRVFQTENLGALDL 909
GSI+GQL VIY PPLQ+VFQTE+L L L
Sbjct: 850 GSIMGQLLVIYFPPLQKVFQTESLSILGL 878
>gi|24638454 ATPase, Ca++ transporting, slow twitch 2 isoform 1 [Homo
sapiens]
Length = 1042
Score = 443 bits (1139), Expect = e-124
Identities = 323/996 (32%), Positives = 501/996 (50%), Gaps = 120/996 (12%)
Query: 63 EDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSA 122
E++ F V+ TGLS V + + G NE A+ + + + ++QF++ L+ +LL +A
Sbjct: 10 EEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAA 69
Query: 123 LVSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNC 172
+S + +E+ TA +L++V A + QE +E ++E L + P
Sbjct: 70 CISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKV 129
Query: 173 LREGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSK 228
R+ + +Q + A+++VPGD+V +++GD++PADIRLT + T L VD+S TGE+ K
Sbjct: 130 YRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIK 189
Query: 229 TDSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPL 287
P+ + N++F GT + G+ GVV+ TG +++ G++ M A E +TPL
Sbjct: 190 HTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPL 249
Query: 288 QKSMDRLGKQLTLFSFGIIGLIMLIGW--------------SQGKQLLSMFTIGVSLAVA 333
Q+ +D G+QL+ +I LI + W S + + F I V+LAVA
Sbjct: 250 QQKLDEFGEQLSK----VISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVA 305
Query: 334 AIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQ 393
AIPEGLP V+ L LG RMAKK IV+ LP VETLGC SV+CSDKTGTLT N+M+V +
Sbjct: 306 AIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCR 365
Query: 394 LVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGK---LVEAGCVA---NNAVI 447
+ D + + + P EV K+ V+ + LVE + N++ +
Sbjct: 366 MFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSAL 425
Query: 448 RKNAV------MGQPTEGALMALAMKMDLSDIK-------------NSYIR---KKE--I 483
N +G+ TE AL L KM++ D + NS I+ KKE +
Sbjct: 426 DYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTL 485
Query: 484 PFSSEQKWMAVKCSLKTEDQEDI--YFMKGALEEVIRYCTMYNNGGIPLPLTP--QQRSF 539
FS ++K M+V C+ + + F+KGA E VI CT G +P+T +Q+
Sbjct: 486 EFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIM 545
Query: 540 CLQEEKRMGSLGLRVLALASGPELGR------------------LTFLGLVGIIDPPRVG 581
+ E GS LR LALA+ R LTF+G VG++DPPR+
Sbjct: 546 SVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIE 605
Query: 582 VKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGK----LQAMSGEEVDSVEKGEL 637
V +V++ ++G+ V MITGD TA+AI R IG+ +A +G E D +
Sbjct: 606 VASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQ 665
Query: 638 ADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTD 697
D F R P HK KI++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT
Sbjct: 666 RDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTA 724
Query: 698 VSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPS 757
V+K A+ M+L DD+FS I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ P
Sbjct: 725 VAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPE 784
Query: 758 PLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIII 817
L +Q+LW+N++ DG PA +LG P D D +PPR+ ++ ++S L + L +
Sbjct: 785 ALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVG 844
Query: 818 SGTL-----------------------FIFWKEMPEDRA-------STPRTTTMTFTCFV 847
+ T+ F+ KE D +P TM + V
Sbjct: 845 AATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLV 904
Query: 848 FFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGAL 907
++ NAL S+ + + + N + S+ S+ ++Y+ PL +FQ L
Sbjct: 905 TIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVT 964
Query: 908 DLLFLTGLASSVFILSELLKLCEKYCCSPKRVQMHP 943
L + ++ V ++ E LK + P + + P
Sbjct: 965 QWLMVLKISLPVILMDETLKFVARNYLEPGKECVQP 1000
>gi|4502285 ATPase, Ca++ transporting, slow twitch 2 isoform 2 [Homo
sapiens]
Length = 997
Score = 442 bits (1136), Expect = e-124
Identities = 322/989 (32%), Positives = 498/989 (50%), Gaps = 120/989 (12%)
Query: 63 EDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSA 122
E++ F V+ TGLS V + + G NE A+ + + + ++QF++ L+ +LL +A
Sbjct: 10 EEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAA 69
Query: 123 LVSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNC 172
+S + +E+ TA +L++V A + QE +E ++E L + P
Sbjct: 70 CISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKV 129
Query: 173 LREGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSK 228
R+ + +Q + A+++VPGD+V +++GD++PADIRLT + T L VD+S TGE+ K
Sbjct: 130 YRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIK 189
Query: 229 TDSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPL 287
P+ + N++F GT + G+ GVV+ TG +++ G++ M A E +TPL
Sbjct: 190 HTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPL 249
Query: 288 QKSMDRLGKQLTLFSFGIIGLIMLIGW--------------SQGKQLLSMFTIGVSLAVA 333
Q+ +D G+QL+ +I LI + W S + + F I V+LAVA
Sbjct: 250 QQKLDEFGEQLSK----VISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVA 305
Query: 334 AIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQ 393
AIPEGLP V+ L LG RMAKK IV+ LP VETLGC SV+CSDKTGTLT N+M+V +
Sbjct: 306 AIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCR 365
Query: 394 LVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGK---LVEAGCVA---NNAVI 447
+ D + + + P EV K+ V+ + LVE + N++ +
Sbjct: 366 MFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSAL 425
Query: 448 RKNAV------MGQPTEGALMALAMKMDLSDIK-------------NSYIR---KKE--I 483
N +G+ TE AL L KM++ D + NS I+ KKE +
Sbjct: 426 DYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTL 485
Query: 484 PFSSEQKWMAVKCSLKTEDQEDI--YFMKGALEEVIRYCTMYNNGGIPLPLTP--QQRSF 539
FS ++K M+V C+ + + F+KGA E VI CT G +P+T +Q+
Sbjct: 486 EFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIM 545
Query: 540 CLQEEKRMGSLGLRVLALASGPELGR------------------LTFLGLVGIIDPPRVG 581
+ E GS LR LALA+ R LTF+G VG++DPPR+
Sbjct: 546 SVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIE 605
Query: 582 VKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGK----LQAMSGEEVDSVEKGEL 637
V +V++ ++G+ V MITGD TA+AI R IG+ +A +G E D +
Sbjct: 606 VASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQ 665
Query: 638 ADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTD 697
D F R P HK KI++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT
Sbjct: 666 RDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTA 724
Query: 698 VSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPS 757
V+K A+ M+L DD+FS I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ P
Sbjct: 725 VAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPE 784
Query: 758 PLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIII 817
L +Q+LW+N++ DG PA +LG P D D +PPR+ ++ ++S L + L +
Sbjct: 785 ALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVG 844
Query: 818 SGTL-----------------------FIFWKEMPEDRA-------STPRTTTMTFTCFV 847
+ T+ F+ KE D +P TM + V
Sbjct: 845 AATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLV 904
Query: 848 FFDLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGAL 907
++ NAL S+ + + + N + S+ S+ ++Y+ PL +FQ L
Sbjct: 905 TIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVT 964
Query: 908 DLLFLTGLASSVFILSELLKLCEKYCCSP 936
L + ++ V ++ E LK + P
Sbjct: 965 QWLMVLKISLPVILMDETLKFVARNYLEP 993
>gi|10835220 ATPase, Ca++ transporting, fast twitch 1 isoform b
[Homo sapiens]
Length = 994
Score = 441 bits (1134), Expect = e-123
Identities = 321/977 (32%), Positives = 497/977 (50%), Gaps = 113/977 (11%)
Query: 63 EDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSA 122
E+ F V TGL+ V + +G NE A+ + +W+ ++QF++ L+ +LL +A
Sbjct: 10 EECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRILLLAA 69
Query: 123 LVSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNC 172
+S + +E+ TA +L+++ A + QE +E ++E L + P
Sbjct: 70 CISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKV 129
Query: 173 LREGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSK 228
R + +Q + AR++VPGD+V +++GD++PADIR+ + T L VD+S TGE+ K
Sbjct: 130 YRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIK 189
Query: 229 TDSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPL 287
P+ + N++F GT + G+ G+V TG ++ G++ M A E KTPL
Sbjct: 190 HTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPL 249
Query: 288 QKSMDRLGKQLTLFSFGIIGLIMLI----------GWSQGKQLLSMFTIGVSLAVAAIPE 337
Q+ +D G+QL+ I + LI G S + + F I V+LAVAAIPE
Sbjct: 250 QQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPE 309
Query: 338 GLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTS 397
GLP V+ L LG RMAKK IV+ LP VETLGC SV+CSDKTGTLT N+M+V ++
Sbjct: 310 GLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFII 369
Query: 398 DGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGK---LVEAGCVA---NNAVIRKNA 451
D + ++ + P EV+K V G+ LVE + N++ + N
Sbjct: 370 DKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALCNDSSLDFNE 429
Query: 452 V------MGQPTEGALMALAMKMDL--SDIK-----------NSYIR---KKE--IPFSS 487
+G+ TE AL L KM++ +D++ NS IR KKE + FS
Sbjct: 430 AKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMKKEFTLEFSR 489
Query: 488 EQKWMAVKCSLKTEDQEDI---YFMKGALEEVIRYCTMYNNGGIPLPLTP--QQRSFCLQ 542
++K M+V CS + + F+KGA E VI C G +PLT +++ +
Sbjct: 490 DRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMAVI 549
Query: 543 EEKRMGSLGLRVLALASGPELGR------------------LTFLGLVGIIDPPRVGVKE 584
+E G LR LALA+ + LTF+G+VG++DPPR V
Sbjct: 550 KEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGMLDPPRKEVTG 609
Query: 585 AVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQ----AMSGEEVDSVEKGELADR 640
++Q+ ++G+ V MITGD TA+AI R IG+ + A +G E D + E +
Sbjct: 610 SIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREA 669
Query: 641 VGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSK 700
+ F R P HK KI++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT V+K
Sbjct: 670 CRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAK 728
Query: 701 EAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLN 760
A+ M+L DD+FS I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ LP L
Sbjct: 729 TASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALI 788
Query: 761 AMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGT 820
+Q+LW+N++ DG PA +LG P D D +PPRS ++ ++S L + + + + T
Sbjct: 789 PVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAAT 848
Query: 821 L------FIFWKEMP--------------EDRA----------STPRTTTMTFTCFVFFD 850
+ F++ ++ P ED P TM + V +
Sbjct: 849 VGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIE 908
Query: 851 LFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDLL 910
+ NAL S+ + + + N L S+ S+ ++Y+ PL +F+ L L
Sbjct: 909 MCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWL 968
Query: 911 FLTGLASSVFILSELLK 927
+ ++ V L E+LK
Sbjct: 969 MVLKISLPVIGLDEILK 985
>gi|27886529 ATPase, Ca++ transporting, fast twitch 1 isoform a
[Homo sapiens]
Length = 1001
Score = 441 bits (1134), Expect = e-123
Identities = 321/977 (32%), Positives = 497/977 (50%), Gaps = 113/977 (11%)
Query: 63 EDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSA 122
E+ F V TGL+ V + +G NE A+ + +W+ ++QF++ L+ +LL +A
Sbjct: 10 EECLAYFGVSETTGLTPDQVKRNLEKYGLNELPAEEGKTLWELVIEQFEDLLVRILLLAA 69
Query: 123 LVSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNC 172
+S + +E+ TA +L+++ A + QE +E ++E L + P
Sbjct: 70 CISFVLAWFEEGEETITAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKV 129
Query: 173 LREGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSK 228
R + +Q + AR++VPGD+V +++GD++PADIR+ + T L VD+S TGE+ K
Sbjct: 130 YRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILAIKSTTLRVDQSILTGESVSVIK 189
Query: 229 TDSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPL 287
P+ + N++F GT + G+ G+V TG ++ G++ M A E KTPL
Sbjct: 190 HTEPVPDPRAVNQDKKNMLFSGTNIAAGKALGIVATTGVGTEIGKIRDQMAATEQDKTPL 249
Query: 288 QKSMDRLGKQLTLFSFGIIGLIMLI----------GWSQGKQLLSMFTIGVSLAVAAIPE 337
Q+ +D G+QL+ I + LI G S + + F I V+LAVAAIPE
Sbjct: 250 QQKLDEFGEQLSKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPE 309
Query: 338 GLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTS 397
GLP V+ L LG RMAKK IV+ LP VETLGC SV+CSDKTGTLT N+M+V ++
Sbjct: 310 GLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFII 369
Query: 398 DGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGK---LVEAGCVA---NNAVIRKNA 451
D + ++ + P EV+K V G+ LVE + N++ + N
Sbjct: 370 DKVDGDICLLNEFSITGSTYAPEGEVLKNDKPVRPGQYDGLVELATICALCNDSSLDFNE 429
Query: 452 V------MGQPTEGALMALAMKMDL--SDIK-----------NSYIR---KKE--IPFSS 487
+G+ TE AL L KM++ +D++ NS IR KKE + FS
Sbjct: 430 AKGVYEKVGEATETALTTLVEKMNVFNTDVRSLSKVERANACNSVIRQLMKKEFTLEFSR 489
Query: 488 EQKWMAVKCSLKTEDQEDI---YFMKGALEEVIRYCTMYNNGGIPLPLTP--QQRSFCLQ 542
++K M+V CS + + F+KGA E VI C G +PLT +++ +
Sbjct: 490 DRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYVRVGTTRVPLTGPVKEKIMAVI 549
Query: 543 EEKRMGSLGLRVLALASGPELGR------------------LTFLGLVGIIDPPRVGVKE 584
+E G LR LALA+ + LTF+G+VG++DPPR V
Sbjct: 550 KEWGTGRDTLRCLALATRDTPPKREEMVLDDSARFLEYETDLTFVGVVGMLDPPRKEVTG 609
Query: 585 AVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKLQ----AMSGEEVDSVEKGELADR 640
++Q+ ++G+ V MITGD TA+AI R IG+ + A +G E D + E +
Sbjct: 610 SIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFGENEEVADRAYTGREFDDLPLAEQREA 669
Query: 641 VGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSK 700
+ F R P HK KI++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT V+K
Sbjct: 670 CRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAK 728
Query: 701 EAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLN 760
A+ M+L DD+FS I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ LP L
Sbjct: 729 TASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALI 788
Query: 761 AMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGT 820
+Q+LW+N++ DG PA +LG P D D +PPRS ++ ++S L + + + + T
Sbjct: 789 PVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVGAAT 848
Query: 821 L------FIFWKEMP--------------EDRA----------STPRTTTMTFTCFVFFD 850
+ F++ ++ P ED P TM + V +
Sbjct: 849 VGAAAWWFLYAEDGPHVNYSQLTHFMQCTEDNTHFEGIDCEVFEAPEPMTMALSVLVTIE 908
Query: 851 LFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDLL 910
+ NAL S+ + + + N L S+ S+ ++Y+ PL +F+ L L
Sbjct: 909 MCNALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDLTQWL 968
Query: 911 FLTGLASSVFILSELLK 927
+ ++ V L E+LK
Sbjct: 969 MVLKISLPVIGLDEILK 985
>gi|28373103 ATPase, Ca++ transporting, ubiquitous isoform a [Homo
sapiens]
Length = 999
Score = 438 bits (1126), Expect = e-122
Identities = 320/978 (32%), Positives = 488/978 (49%), Gaps = 117/978 (11%)
Query: 64 DLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSAL 123
D+ R F V GLS VT R +G NE ++ + +W+ L+QF++ L+ +LL +AL
Sbjct: 11 DVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAAL 70
Query: 124 VSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNCL 173
VS + +E+ TA +L++V A + QE +E ++E L + P +
Sbjct: 71 VSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVI 130
Query: 174 REGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSKT 229
R + +Q + AR++VPGD+V +++GD++PAD+RL E+ T L VD+S TGE+ +K
Sbjct: 131 RSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKH 190
Query: 230 DSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQ 288
+ + N++F GT + G+ GV + TG ++ G++ M A E +TPLQ
Sbjct: 191 TEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQ 250
Query: 289 KSMDRLGKQLTLFSFGIIGLIMLI----------GWSQGKQLLSMFTIGVSLAVAAIPEG 338
+ +D G+QL+ I + +I G S + + F I V+LAVAAIPEG
Sbjct: 251 RKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEG 310
Query: 339 LPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSD 398
LP V+ L LG RMA+K IV+ LP VETLGC SV+CSDKTGTLT N+M+V ++
Sbjct: 311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVA 370
Query: 399 GLRA--------EVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKN 450
A +SG Y +G V +F + +L + N++ + N
Sbjct: 371 EADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLV--ELATICALCNDSALDYN 428
Query: 451 AV------MGQPTEGALMALAMKMDLSD------------------IKNSYIRKKEIPFS 486
+G+ TE AL L KM++ D IK ++ + FS
Sbjct: 429 EAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFS 488
Query: 487 SEQKWMAVKCSLKTED---QEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQE 543
++K M+V C+ Q F+KGA E VI C+ G PLTP R L +
Sbjct: 489 RDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAK 548
Query: 544 EKRMGSLG--LRVLALASGPELGR------------------LTFLGLVGIIDPPRVGVK 583
+ GS LR LALA+ R LTF+G VG++DPPR V
Sbjct: 549 IRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVA 608
Query: 584 EAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKL----QAMSGEEVDSVEKGELAD 639
+ ++G+ V MITGD TA+AI R +G+ +A +G E D + +
Sbjct: 609 ACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQ 668
Query: 640 RVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVS 699
F R P HK +I++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT V+
Sbjct: 669 ACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVA 727
Query: 700 KEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPL 759
K AA M+L DD+F++I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ + LP L
Sbjct: 728 KSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEAL 787
Query: 760 NAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILS-----RALILKILMSAA 814
+Q+LW+N++ DG PA +LG P D D + PRS R+ ++S R L + + + A
Sbjct: 788 IPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLA 847
Query: 815 IIISGT-LFIFWKEMP--------------EDRA----------STPRTTTMTFTCFVFF 849
+ + T F++ E P ED + TTM + V
Sbjct: 848 TVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTI 907
Query: 850 DLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDL 909
++ NAL S+ + + + N L +V S+ ++ +PPL +FQ L
Sbjct: 908 EMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQW 967
Query: 910 LFLTGLASSVFILSELLK 927
+ + ++ V +L E LK
Sbjct: 968 VVVLQISLPVILLDEALK 985
>gi|28373115 ATPase, Ca++ transporting, ubiquitous isoform c [Homo
sapiens]
Length = 1029
Score = 438 bits (1126), Expect = e-122
Identities = 320/978 (32%), Positives = 488/978 (49%), Gaps = 117/978 (11%)
Query: 64 DLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSAL 123
D+ R F V GLS VT R +G NE ++ + +W+ L+QF++ L+ +LL +AL
Sbjct: 11 DVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAAL 70
Query: 124 VSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNCL 173
VS + +E+ TA +L++V A + QE +E ++E L + P +
Sbjct: 71 VSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVI 130
Query: 174 REGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSKT 229
R + +Q + AR++VPGD+V +++GD++PAD+RL E+ T L VD+S TGE+ +K
Sbjct: 131 RSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKH 190
Query: 230 DSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQ 288
+ + N++F GT + G+ GV + TG ++ G++ M A E +TPLQ
Sbjct: 191 TEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQ 250
Query: 289 KSMDRLGKQLTLFSFGIIGLIMLI----------GWSQGKQLLSMFTIGVSLAVAAIPEG 338
+ +D G+QL+ I + +I G S + + F I V+LAVAAIPEG
Sbjct: 251 RKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEG 310
Query: 339 LPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSD 398
LP V+ L LG RMA+K IV+ LP VETLGC SV+CSDKTGTLT N+M+V ++
Sbjct: 311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVA 370
Query: 399 GLRA--------EVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKN 450
A +SG Y +G V +F + +L + N++ + N
Sbjct: 371 EADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLV--ELATICALCNDSALDYN 428
Query: 451 AV------MGQPTEGALMALAMKMDLSD------------------IKNSYIRKKEIPFS 486
+G+ TE AL L KM++ D IK ++ + FS
Sbjct: 429 EAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFS 488
Query: 487 SEQKWMAVKCSLKTED---QEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQE 543
++K M+V C+ Q F+KGA E VI C+ G PLTP R L +
Sbjct: 489 RDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAK 548
Query: 544 EKRMGSLG--LRVLALASGPELGR------------------LTFLGLVGIIDPPRVGVK 583
+ GS LR LALA+ R LTF+G VG++DPPR V
Sbjct: 549 IRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVA 608
Query: 584 EAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKL----QAMSGEEVDSVEKGELAD 639
+ ++G+ V MITGD TA+AI R +G+ +A +G E D + +
Sbjct: 609 ACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQ 668
Query: 640 RVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVS 699
F R P HK +I++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT V+
Sbjct: 669 ACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVA 727
Query: 700 KEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPL 759
K AA M+L DD+F++I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ + LP L
Sbjct: 728 KSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEAL 787
Query: 760 NAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILS-----RALILKILMSAA 814
+Q+LW+N++ DG PA +LG P D D + PRS R+ ++S R L + + + A
Sbjct: 788 IPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLA 847
Query: 815 IIISGT-LFIFWKEMP--------------EDRA----------STPRTTTMTFTCFVFF 849
+ + T F++ E P ED + TTM + V
Sbjct: 848 TVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTI 907
Query: 850 DLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDL 909
++ NAL S+ + + + N L +V S+ ++ +PPL +FQ L
Sbjct: 908 EMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQW 967
Query: 910 LFLTGLASSVFILSELLK 927
+ + ++ V +L E LK
Sbjct: 968 VVVLQISLPVILLDEALK 985
>gi|28373113 ATPase, Ca++ transporting, ubiquitous isoform f [Homo
sapiens]
Length = 998
Score = 438 bits (1126), Expect = e-122
Identities = 320/978 (32%), Positives = 488/978 (49%), Gaps = 117/978 (11%)
Query: 64 DLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSAL 123
D+ R F V GLS VT R +G NE ++ + +W+ L+QF++ L+ +LL +AL
Sbjct: 11 DVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAAL 70
Query: 124 VSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNCL 173
VS + +E+ TA +L++V A + QE +E ++E L + P +
Sbjct: 71 VSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVI 130
Query: 174 REGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSKT 229
R + +Q + AR++VPGD+V +++GD++PAD+RL E+ T L VD+S TGE+ +K
Sbjct: 131 RSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKH 190
Query: 230 DSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQ 288
+ + N++F GT + G+ GV + TG ++ G++ M A E +TPLQ
Sbjct: 191 TEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQ 250
Query: 289 KSMDRLGKQLTLFSFGIIGLIMLI----------GWSQGKQLLSMFTIGVSLAVAAIPEG 338
+ +D G+QL+ I + +I G S + + F I V+LAVAAIPEG
Sbjct: 251 RKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEG 310
Query: 339 LPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSD 398
LP V+ L LG RMA+K IV+ LP VETLGC SV+CSDKTGTLT N+M+V ++
Sbjct: 311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVA 370
Query: 399 GLRA--------EVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKN 450
A +SG Y +G V +F + +L + N++ + N
Sbjct: 371 EADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLV--ELATICALCNDSALDYN 428
Query: 451 AV------MGQPTEGALMALAMKMDLSD------------------IKNSYIRKKEIPFS 486
+G+ TE AL L KM++ D IK ++ + FS
Sbjct: 429 EAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFS 488
Query: 487 SEQKWMAVKCSLKTED---QEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQE 543
++K M+V C+ Q F+KGA E VI C+ G PLTP R L +
Sbjct: 489 RDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAK 548
Query: 544 EKRMGSLG--LRVLALASGPELGR------------------LTFLGLVGIIDPPRVGVK 583
+ GS LR LALA+ R LTF+G VG++DPPR V
Sbjct: 549 IRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVA 608
Query: 584 EAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKL----QAMSGEEVDSVEKGELAD 639
+ ++G+ V MITGD TA+AI R +G+ +A +G E D + +
Sbjct: 609 ACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQ 668
Query: 640 RVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVS 699
F R P HK +I++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT V+
Sbjct: 669 ACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVA 727
Query: 700 KEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPL 759
K AA M+L DD+F++I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ + LP L
Sbjct: 728 KSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEAL 787
Query: 760 NAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILS-----RALILKILMSAA 814
+Q+LW+N++ DG PA +LG P D D + PRS R+ ++S R L + + + A
Sbjct: 788 IPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLA 847
Query: 815 IIISGT-LFIFWKEMP--------------EDRA----------STPRTTTMTFTCFVFF 849
+ + T F++ E P ED + TTM + V
Sbjct: 848 TVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTI 907
Query: 850 DLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDL 909
++ NAL S+ + + + N L +V S+ ++ +PPL +FQ L
Sbjct: 908 EMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQW 967
Query: 910 LFLTGLASSVFILSELLK 927
+ + ++ V +L E LK
Sbjct: 968 VVVLQISLPVILLDEALK 985
>gi|28373111 ATPase, Ca++ transporting, ubiquitous isoform c [Homo
sapiens]
Length = 1029
Score = 438 bits (1126), Expect = e-122
Identities = 320/978 (32%), Positives = 488/978 (49%), Gaps = 117/978 (11%)
Query: 64 DLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSAL 123
D+ R F V GLS VT R +G NE ++ + +W+ L+QF++ L+ +LL +AL
Sbjct: 11 DVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAAL 70
Query: 124 VSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNCL 173
VS + +E+ TA +L++V A + QE +E ++E L + P +
Sbjct: 71 VSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVI 130
Query: 174 REGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSKT 229
R + +Q + AR++VPGD+V +++GD++PAD+RL E+ T L VD+S TGE+ +K
Sbjct: 131 RSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKH 190
Query: 230 DSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQ 288
+ + N++F GT + G+ GV + TG ++ G++ M A E +TPLQ
Sbjct: 191 TEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQ 250
Query: 289 KSMDRLGKQLTLFSFGIIGLIMLI----------GWSQGKQLLSMFTIGVSLAVAAIPEG 338
+ +D G+QL+ I + +I G S + + F I V+LAVAAIPEG
Sbjct: 251 RKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEG 310
Query: 339 LPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSD 398
LP V+ L LG RMA+K IV+ LP VETLGC SV+CSDKTGTLT N+M+V ++
Sbjct: 311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVA 370
Query: 399 GLRA--------EVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKN 450
A +SG Y +G V +F + +L + N++ + N
Sbjct: 371 EADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLV--ELATICALCNDSALDYN 428
Query: 451 AV------MGQPTEGALMALAMKMDLSD------------------IKNSYIRKKEIPFS 486
+G+ TE AL L KM++ D IK ++ + FS
Sbjct: 429 EAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFS 488
Query: 487 SEQKWMAVKCSLKTED---QEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQE 543
++K M+V C+ Q F+KGA E VI C+ G PLTP R L +
Sbjct: 489 RDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAK 548
Query: 544 EKRMGSLG--LRVLALASGPELGR------------------LTFLGLVGIIDPPRVGVK 583
+ GS LR LALA+ R LTF+G VG++DPPR V
Sbjct: 549 IRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVA 608
Query: 584 EAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKL----QAMSGEEVDSVEKGELAD 639
+ ++G+ V MITGD TA+AI R +G+ +A +G E D + +
Sbjct: 609 ACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQ 668
Query: 640 RVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVS 699
F R P HK +I++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT V+
Sbjct: 669 ACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVA 727
Query: 700 KEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPL 759
K AA M+L DD+F++I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ + LP L
Sbjct: 728 KSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEAL 787
Query: 760 NAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILS-----RALILKILMSAA 814
+Q+LW+N++ DG PA +LG P D D + PRS R+ ++S R L + + + A
Sbjct: 788 IPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLA 847
Query: 815 IIISGT-LFIFWKEMP--------------EDRA----------STPRTTTMTFTCFVFF 849
+ + T F++ E P ED + TTM + V
Sbjct: 848 TVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTI 907
Query: 850 DLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDL 909
++ NAL S+ + + + N L +V S+ ++ +PPL +FQ L
Sbjct: 908 EMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQW 967
Query: 910 LFLTGLASSVFILSELLK 927
+ + ++ V +L E LK
Sbjct: 968 VVVLQISLPVILLDEALK 985
>gi|28373109 ATPase, Ca++ transporting, ubiquitous isoform b [Homo
sapiens]
Length = 1043
Score = 438 bits (1126), Expect = e-122
Identities = 320/978 (32%), Positives = 488/978 (49%), Gaps = 117/978 (11%)
Query: 64 DLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSAL 123
D+ R F V GLS VT R +G NE ++ + +W+ L+QF++ L+ +LL +AL
Sbjct: 11 DVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAAL 70
Query: 124 VSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNCL 173
VS + +E+ TA +L++V A + QE +E ++E L + P +
Sbjct: 71 VSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVI 130
Query: 174 REGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSKT 229
R + +Q + AR++VPGD+V +++GD++PAD+RL E+ T L VD+S TGE+ +K
Sbjct: 131 RSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKH 190
Query: 230 DSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQ 288
+ + N++F GT + G+ GV + TG ++ G++ M A E +TPLQ
Sbjct: 191 TEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQ 250
Query: 289 KSMDRLGKQLTLFSFGIIGLIMLI----------GWSQGKQLLSMFTIGVSLAVAAIPEG 338
+ +D G+QL+ I + +I G S + + F I V+LAVAAIPEG
Sbjct: 251 RKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEG 310
Query: 339 LPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSD 398
LP V+ L LG RMA+K IV+ LP VETLGC SV+CSDKTGTLT N+M+V ++
Sbjct: 311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVA 370
Query: 399 GLRA--------EVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKN 450
A +SG Y +G V +F + +L + N++ + N
Sbjct: 371 EADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLV--ELATICALCNDSALDYN 428
Query: 451 AV------MGQPTEGALMALAMKMDLSD------------------IKNSYIRKKEIPFS 486
+G+ TE AL L KM++ D IK ++ + FS
Sbjct: 429 EAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFS 488
Query: 487 SEQKWMAVKCSLKTED---QEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQE 543
++K M+V C+ Q F+KGA E VI C+ G PLTP R L +
Sbjct: 489 RDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAK 548
Query: 544 EKRMGSLG--LRVLALASGPELGR------------------LTFLGLVGIIDPPRVGVK 583
+ GS LR LALA+ R LTF+G VG++DPPR V
Sbjct: 549 IRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVA 608
Query: 584 EAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKL----QAMSGEEVDSVEKGELAD 639
+ ++G+ V MITGD TA+AI R +G+ +A +G E D + +
Sbjct: 609 ACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQ 668
Query: 640 RVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVS 699
F R P HK +I++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT V+
Sbjct: 669 ACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVA 727
Query: 700 KEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPL 759
K AA M+L DD+F++I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ + LP L
Sbjct: 728 KSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEAL 787
Query: 760 NAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILS-----RALILKILMSAA 814
+Q+LW+N++ DG PA +LG P D D + PRS R+ ++S R L + + + A
Sbjct: 788 IPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLA 847
Query: 815 IIISGT-LFIFWKEMP--------------EDRA----------STPRTTTMTFTCFVFF 849
+ + T F++ E P ED + TTM + V
Sbjct: 848 TVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTI 907
Query: 850 DLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDL 909
++ NAL S+ + + + N L +V S+ ++ +PPL +FQ L
Sbjct: 908 EMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQW 967
Query: 910 LFLTGLASSVFILSELLK 927
+ + ++ V +L E LK
Sbjct: 968 VVVLQISLPVILLDEALK 985
>gi|28373107 ATPase, Ca++ transporting, ubiquitous isoform d [Homo
sapiens]
Length = 1044
Score = 438 bits (1126), Expect = e-122
Identities = 320/978 (32%), Positives = 488/978 (49%), Gaps = 117/978 (11%)
Query: 64 DLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSAL 123
D+ R F V GLS VT R +G NE ++ + +W+ L+QF++ L+ +LL +AL
Sbjct: 11 DVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAAL 70
Query: 124 VSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNCL 173
VS + +E+ TA +L++V A + QE +E ++E L + P +
Sbjct: 71 VSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVI 130
Query: 174 REGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSKT 229
R + +Q + AR++VPGD+V +++GD++PAD+RL E+ T L VD+S TGE+ +K
Sbjct: 131 RSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKH 190
Query: 230 DSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQ 288
+ + N++F GT + G+ GV + TG ++ G++ M A E +TPLQ
Sbjct: 191 TEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQ 250
Query: 289 KSMDRLGKQLTLFSFGIIGLIMLI----------GWSQGKQLLSMFTIGVSLAVAAIPEG 338
+ +D G+QL+ I + +I G S + + F I V+LAVAAIPEG
Sbjct: 251 RKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEG 310
Query: 339 LPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSD 398
LP V+ L LG RMA+K IV+ LP VETLGC SV+CSDKTGTLT N+M+V ++
Sbjct: 311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVA 370
Query: 399 GLRA--------EVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKN 450
A +SG Y +G V +F + +L + N++ + N
Sbjct: 371 EADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLV--ELATICALCNDSALDYN 428
Query: 451 AV------MGQPTEGALMALAMKMDLSD------------------IKNSYIRKKEIPFS 486
+G+ TE AL L KM++ D IK ++ + FS
Sbjct: 429 EAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFS 488
Query: 487 SEQKWMAVKCSLKTED---QEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQE 543
++K M+V C+ Q F+KGA E VI C+ G PLTP R L +
Sbjct: 489 RDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAK 548
Query: 544 EKRMGSLG--LRVLALASGPELGR------------------LTFLGLVGIIDPPRVGVK 583
+ GS LR LALA+ R LTF+G VG++DPPR V
Sbjct: 549 IRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVA 608
Query: 584 EAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKL----QAMSGEEVDSVEKGELAD 639
+ ++G+ V MITGD TA+AI R +G+ +A +G E D + +
Sbjct: 609 ACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQ 668
Query: 640 RVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVS 699
F R P HK +I++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT V+
Sbjct: 669 ACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVA 727
Query: 700 KEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPL 759
K AA M+L DD+F++I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ + LP L
Sbjct: 728 KSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEAL 787
Query: 760 NAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILS-----RALILKILMSAA 814
+Q+LW+N++ DG PA +LG P D D + PRS R+ ++S R L + + + A
Sbjct: 788 IPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLA 847
Query: 815 IIISGT-LFIFWKEMP--------------EDRA----------STPRTTTMTFTCFVFF 849
+ + T F++ E P ED + TTM + V
Sbjct: 848 TVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTI 907
Query: 850 DLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDL 909
++ NAL S+ + + + N L +V S+ ++ +PPL +FQ L
Sbjct: 908 EMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQW 967
Query: 910 LFLTGLASSVFILSELLK 927
+ + ++ V +L E LK
Sbjct: 968 VVVLQISLPVILLDEALK 985
>gi|28373105 ATPase, Ca++ transporting, ubiquitous isoform e [Homo
sapiens]
Length = 1052
Score = 438 bits (1126), Expect = e-122
Identities = 320/978 (32%), Positives = 488/978 (49%), Gaps = 117/978 (11%)
Query: 64 DLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSAL 123
D+ R F V GLS VT R +G NE ++ + +W+ L+QF++ L+ +LL +AL
Sbjct: 11 DVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAAL 70
Query: 124 VSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNCL 173
VS + +E+ TA +L++V A + QE +E ++E L + P +
Sbjct: 71 VSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVI 130
Query: 174 REGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEV--TDLLVDESSFTGEAEPCSKT 229
R + +Q + AR++VPGD+V +++GD++PAD+RL E+ T L VD+S TGE+ +K
Sbjct: 131 RSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKH 190
Query: 230 DSPLTGGGDLTT-LSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQ 288
+ + N++F GT + G+ GV + TG ++ G++ M A E +TPLQ
Sbjct: 191 TEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQ 250
Query: 289 KSMDRLGKQLTLFSFGIIGLIMLI----------GWSQGKQLLSMFTIGVSLAVAAIPEG 338
+ +D G+QL+ I + +I G S + + F I V+LAVAAIPEG
Sbjct: 251 RKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEG 310
Query: 339 LPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSD 398
LP V+ L LG RMA+K IV+ LP VETLGC SV+CSDKTGTLT N+M+V ++
Sbjct: 311 LPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVA 370
Query: 399 GLRA--------EVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKN 450
A +SG Y +G V +F + +L + N++ + N
Sbjct: 371 EADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLV--ELATICALCNDSALDYN 428
Query: 451 AV------MGQPTEGALMALAMKMDLSD------------------IKNSYIRKKEIPFS 486
+G+ TE AL L KM++ D IK ++ + FS
Sbjct: 429 EAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFS 488
Query: 487 SEQKWMAVKCSLKTED---QEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQE 543
++K M+V C+ Q F+KGA E VI C+ G PLTP R L +
Sbjct: 489 RDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAK 548
Query: 544 EKRMGSLG--LRVLALASGPELGR------------------LTFLGLVGIIDPPRVGVK 583
+ GS LR LALA+ R LTF+G VG++DPPR V
Sbjct: 549 IRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVA 608
Query: 584 EAVQVLSESGVSVKMITGDALETALAIGRNIGLCNGKL----QAMSGEEVDSVEKGELAD 639
+ ++G+ V MITGD TA+AI R +G+ +A +G E D + +
Sbjct: 609 ACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQ 668
Query: 640 RVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVS 699
F R P HK +I++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT V+
Sbjct: 669 ACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVA 727
Query: 700 KEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPL 759
K AA M+L DD+F++I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ + LP L
Sbjct: 728 KSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEAL 787
Query: 760 NAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILS-----RALILKILMSAA 814
+Q+LW+N++ DG PA +LG P D D + PRS R+ ++S R L + + + A
Sbjct: 788 IPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLA 847
Query: 815 IIISGT-LFIFWKEMP--------------EDRA----------STPRTTTMTFTCFVFF 849
+ + T F++ E P ED + TTM + V
Sbjct: 848 TVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTI 907
Query: 850 DLFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDL 909
++ NAL S+ + + + N L +V S+ ++ +PPL +FQ L
Sbjct: 908 EMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQW 967
Query: 910 LFLTGLASSVFILSELLK 927
+ + ++ V +L E LK
Sbjct: 968 VVVLQISLPVILLDEALK 985
>gi|209413709 ATPase, Ca++ transporting, slow twitch 2 isoform 3
[Homo sapiens]
Length = 1015
Score = 404 bits (1037), Expect = e-112
Identities = 307/993 (30%), Positives = 484/993 (48%), Gaps = 141/993 (14%)
Query: 63 EDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSA 122
E++ F V+ TGLS V + + G NE A+ + + + ++QF++ L+ +LL +A
Sbjct: 10 EEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAA 69
Query: 123 LVSVLTKEYEDAVSIATA-------VLVVVTVAFI---QEYRSEKSLEELTKMVPPECNC 172
+S + +E+ TA +L++V A + QE +E ++E L + P
Sbjct: 70 CISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKV 129
Query: 173 LREGK--LQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTD 230
R+ + +Q + A+++VPGD+V ++ + + + TD + D + + +
Sbjct: 130 YRQDRKSVQRIKAKDIVPGDIVEIA-----GESVSVIKHTDPVPDPRAVNQDKK------ 178
Query: 231 SPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKS 290
N++F GT + G+ GVV+ TG +++ G++ M A E +TPLQ+
Sbjct: 179 -------------NMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQK 225
Query: 291 MDRLGKQLTLFSFGIIGLIMLIGW--------------SQGKQLLSMFTIGVSLAVAAIP 336
+D G+QL+ +I LI + W S + + F I V+LAVAAIP
Sbjct: 226 LDEFGEQLSK----VISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIP 281
Query: 337 EGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVT 396
EGLP V+ L LG RMAKK IV+ LP VETLGC SV+CSDKTGTLT N+M+V ++
Sbjct: 282 EGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFI 341
Query: 397 SDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGK---LVEAGCVA---NNAVIRKN 450
D + + + P EV K+ V+ + LVE + N++ + N
Sbjct: 342 LDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYN 401
Query: 451 AV------MGQPTEGALMALAMKMDLSDIK-------------NSYIR---KKE--IPFS 486
+G+ TE AL L KM++ D + NS I+ KKE + FS
Sbjct: 402 EAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFS 461
Query: 487 SEQKWMAVKCSLKTEDQEDI--YFMKGALEEVIRYCTMYNNGGIPLPLTP--QQRSFCLQ 542
++K M+V C+ + + F+KGA E VI CT G +P+T +Q+ +
Sbjct: 462 RDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVI 521
Query: 543 EEKRMGSLGLRVLALASGPELGR------------------LTFLGLVGIIDPPRVGVKE 584
E GS LR LALA+ R LTF+G VG++DPPR+ V
Sbjct: 522 REWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVAS 581
Query: 585 AVQVLSESGVSVKMITGDALETALAIGRNIGLCNGK----LQAMSGEEVDSVEKGELADR 640
+V++ ++G+ V MITGD TA+AI R IG+ +A +G E D + D
Sbjct: 582 SVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDA 641
Query: 641 VGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSK 700
F R P HK KI++ LQ I AMTGDGVNDA ALK A+IGIAMG +GT V+K
Sbjct: 642 CLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAK 700
Query: 701 EAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLN 760
A+ M+L DD+FS I+ AVEEG+ I+ N+K F+R+ +S+++ + I L+ P L
Sbjct: 701 TASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALI 760
Query: 761 AMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAAIIISGT 820
+Q+LW+N++ DG PA +LG P D D +PPR+ ++ ++S L + L + + T
Sbjct: 761 PVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAAT 820
Query: 821 L-----------------------FIFWKEMPEDRA-------STPRTTTMTFTCFVFFD 850
+ F+ KE D +P TM + V +
Sbjct: 821 VGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIE 880
Query: 851 LFNALTCRSQTKLIFEIGFLRNHMFLYSVLGSILGQLAVIYIPPLQRVFQTENLGALDLL 910
+ NAL S+ + + + N + S+ S+ ++Y+ PL +FQ L L
Sbjct: 881 MCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWL 940
Query: 911 FLTGLASSVFILSELLKLCEKYCCSPKRVQMHP 943
+ ++ V ++ E LK + P + + P
Sbjct: 941 MVLKISLPVILMDETLKFVARNYLEPGKECVQP 973
>gi|4502271 Na+/K+ -ATPase alpha 2 subunit proprotein [Homo sapiens]
Length = 1020
Score = 361 bits (926), Expect = 2e-99
Identities = 274/869 (31%), Positives = 415/869 (47%), Gaps = 104/869 (11%)
Query: 17 GGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFCVDLHTG 76
G GR+Y E ++ + K +++ KK A+ K ++L R + VDL G
Sbjct: 4 GAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDH---KLSLDELGRKYQVDLSKG 60
Query: 77 LSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDA-- 134
L+ G N + P W K+ Q +LL A++ L + A
Sbjct: 61 LTNQRAQDVLARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAAME 120
Query: 135 -----------VSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPECNCLREGKLQHLLA 183
V +A V+V ++ QE +S K ++ MVP + +REG+ + A
Sbjct: 121 DEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEKMQINA 180
Query: 184 RELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLS 243
E+V GD+V + GDR+PAD+R+ VD SS TGE+EP +T SP +
Sbjct: 181 EEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEP--QTRSPEFTHENPLETR 238
Query: 244 NIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLT---L 300
NI F T G +G+VI TG+ + G + + E +TP+ ++ + +T +
Sbjct: 239 NICFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAV 298
Query: 301 F---SFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKK 357
F SF ++ LI+ W + +F IG+ VA +PEGL V V L L RMA+K
Sbjct: 299 FLGVSFFVLSLILGYSWLEAV----IFLIGI--IVANVPEGLLATVTVCLTLTAKRMARK 352
Query: 358 RVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRA-----EVSGVGYDGQ 412
+VK L VETLG S +CSDKTGTLT N MTV + + + + SG +D +
Sbjct: 353 NCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKR 412
Query: 413 GTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSD 472
P+ + + + + +AG N + K G +E AL+ +++
Sbjct: 413 S-----PTWTALSRIAGLCNRAVFKAG--QENISVSKRDTAGDASESALLK-CIELSCGS 464
Query: 473 IKNSYIRKK---EIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIP 529
++ R EIPF+S K+ + Q + MKGA E ++ C+ G
Sbjct: 465 VRKMRDRNPKVAEIPFNSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKE 524
Query: 530 LPLTPQQRSFCLQEEKRMGSLGLRVLA-----LASGP----------ELG----RLTFLG 570
+PL + + +G LG RVL L SG EL +L F+G
Sbjct: 525 IPLDKEMQDAFQNAYMELGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEKLCFVG 584
Query: 571 LVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCN------------ 618
L+ +IDPPR V +AV +G+ V M+TGD TA AI + +G+ +
Sbjct: 585 LMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAAR 644
Query: 619 --------------------GKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKI 658
L+ M+ E++D + K VF RTSP+ KL I
Sbjct: 645 LNIPMSQVNPREAKACVVHGSDLKDMTSEQLDEILKNHTE------IVFARTSPQQKLII 698
Query: 659 IKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNA 718
++ Q GAIVA+TGDGVND+ ALK ADIGIAMG +G+DVSK+AA+MIL+DD+F++I+
Sbjct: 699 VEGCQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTG 758
Query: 719 VEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQS 778
VEEG+ IF N+K + + L+++I ++ L + N+P PL + IL I++ D PA S
Sbjct: 759 VEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAIS 818
Query: 779 LGVEPVDKDAF-RQPPRSVRDTILSRALI 806
L E + D RQP S D +++ LI
Sbjct: 819 LAYEAAESDIMKRQPRNSQTDKLVNERLI 847
>gi|237681109 Na+/K+ -ATPase alpha 1 subunit isoform c [Homo
sapiens]
Length = 1023
Score = 354 bits (909), Expect = 2e-97
Identities = 271/856 (31%), Positives = 416/856 (48%), Gaps = 95/856 (11%)
Query: 30 EEALIDEQSELKAIE--KEKKVTALPPKEAC---KCQKEDLARAFCVDLHTGLSEFSVTQ 84
E A + EQ + K + K++ + L + + K ++L R + DL GL+ +
Sbjct: 11 EPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAE 70
Query: 85 RRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDA---------- 134
G N + P W K+ Q +LL A++ L + A
Sbjct: 71 ILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNL 130
Query: 135 ---VSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPECNCLREGKLQHLLARELVPGDV 191
V ++ V++ ++ QE +S K +E MVP + +R G+ + A E+V GD+
Sbjct: 131 YLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDL 190
Query: 192 VSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSP-LTGGGDLTTLSNIVFMGT 250
V + GDRIPAD+R+ VD SS TGE+EP +T SP T L T NI F T
Sbjct: 191 VEVKGGDRIPADLRIISANGCKVDNSSLTGESEP--QTRSPDFTNENPLET-RNIAFFST 247
Query: 251 LVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLT---LF---SFG 304
G +G+V+ TG+ + G + + E +TP+ ++ +T +F SF
Sbjct: 248 NCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFF 307
Query: 305 IIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKL 364
I+ LI+ W + +F IG+ VA +PEGL V V L L RMA+K +VK L
Sbjct: 308 ILSLILEYTWLEAV----IFLIGI--IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNL 361
Query: 365 PIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRA-----EVSGVGYDGQGTVCLLP 419
VETLG S +CSDKTGTLT N MTV + + + SGV +D L
Sbjct: 362 EAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLAL 421
Query: 420 SKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKM--DLSDIKNSY 477
S+ I N +V + + N I K AV G +E AL+ + +++ Y
Sbjct: 422 SR--IAGLCNRAVFQANQ-----ENLPILKRAVAGDASESALLKCIELCCGSVKEMRERY 474
Query: 478 IRKKEIPFSSEQKW-MAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQ 536
+ EIPF+S K+ +++ + T + + + MKGA E ++ C+ G PL +
Sbjct: 475 AKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEEL 534
Query: 537 RSFCLQEEKRMGSLGLRVLALA-------SGPE------------LGRLTFLGLVGIIDP 577
+ +G LG RVL PE + L F+GL+ +IDP
Sbjct: 535 KDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDP 594
Query: 578 PRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCN------------------- 618
PR V +AV +G+ V M+TGD TA AI + +G+ +
Sbjct: 595 PRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQ 654
Query: 619 -----GKLQAMSGEEVDSVEKGELAD--RVGKVSVFFRTSPKHKLKIIKALQESGAIVAM 671
K + G ++ + +L D + VF RTSP+ KL I++ Q GAIVA+
Sbjct: 655 VNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAV 714
Query: 672 TGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKN 731
TGDGVND+ ALK ADIG+AMG G+DVSK+AA+MIL+DD+F++I+ VEEG+ IF N+K
Sbjct: 715 TGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 774
Query: 732 FVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQ 791
+ + L+++I ++ + + N+P PL + IL I++ D PA SL E + D ++
Sbjct: 775 SIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKR 834
Query: 792 PPRSVR-DTILSRALI 806
PR+ + D +++ LI
Sbjct: 835 QPRNPKTDKLVNERLI 850
>gi|21361181 Na+/K+ -ATPase alpha 1 subunit isoform a [Homo sapiens]
Length = 1023
Score = 354 bits (909), Expect = 2e-97
Identities = 271/856 (31%), Positives = 416/856 (48%), Gaps = 95/856 (11%)
Query: 30 EEALIDEQSELKAIE--KEKKVTALPPKEAC---KCQKEDLARAFCVDLHTGLSEFSVTQ 84
E A + EQ + K + K++ + L + + K ++L R + DL GL+ +
Sbjct: 11 EPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAE 70
Query: 85 RRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDA---------- 134
G N + P W K+ Q +LL A++ L + A
Sbjct: 71 ILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNL 130
Query: 135 ---VSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPECNCLREGKLQHLLARELVPGDV 191
V ++ V++ ++ QE +S K +E MVP + +R G+ + A E+V GD+
Sbjct: 131 YLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVVVGDL 190
Query: 192 VSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSP-LTGGGDLTTLSNIVFMGT 250
V + GDRIPAD+R+ VD SS TGE+EP +T SP T L T NI F T
Sbjct: 191 VEVKGGDRIPADLRIISANGCKVDNSSLTGESEP--QTRSPDFTNENPLET-RNIAFFST 247
Query: 251 LVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLT---LF---SFG 304
G +G+V+ TG+ + G + + E +TP+ ++ +T +F SF
Sbjct: 248 NCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFF 307
Query: 305 IIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKL 364
I+ LI+ W + +F IG+ VA +PEGL V V L L RMA+K +VK L
Sbjct: 308 ILSLILEYTWLEAV----IFLIGI--IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNL 361
Query: 365 PIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRA-----EVSGVGYDGQGTVCLLP 419
VETLG S +CSDKTGTLT N MTV + + + SGV +D L
Sbjct: 362 EAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLAL 421
Query: 420 SKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKM--DLSDIKNSY 477
S+ I N +V + + N I K AV G +E AL+ + +++ Y
Sbjct: 422 SR--IAGLCNRAVFQANQ-----ENLPILKRAVAGDASESALLKCIELCCGSVKEMRERY 474
Query: 478 IRKKEIPFSSEQKW-MAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQ 536
+ EIPF+S K+ +++ + T + + + MKGA E ++ C+ G PL +
Sbjct: 475 AKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEEL 534
Query: 537 RSFCLQEEKRMGSLGLRVLALA-------SGPE------------LGRLTFLGLVGIIDP 577
+ +G LG RVL PE + L F+GL+ +IDP
Sbjct: 535 KDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDP 594
Query: 578 PRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCN------------------- 618
PR V +AV +G+ V M+TGD TA AI + +G+ +
Sbjct: 595 PRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQ 654
Query: 619 -----GKLQAMSGEEVDSVEKGELAD--RVGKVSVFFRTSPKHKLKIIKALQESGAIVAM 671
K + G ++ + +L D + VF RTSP+ KL I++ Q GAIVA+
Sbjct: 655 VNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAV 714
Query: 672 TGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKN 731
TGDGVND+ ALK ADIG+AMG G+DVSK+AA+MIL+DD+F++I+ VEEG+ IF N+K
Sbjct: 715 TGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKK 774
Query: 732 FVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQ 791
+ + L+++I ++ + + N+P PL + IL I++ D PA SL E + D ++
Sbjct: 775 SIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKR 834
Query: 792 PPRSVR-DTILSRALI 806
PR+ + D +++ LI
Sbjct: 835 QPRNPKTDKLVNERLI 850
>gi|237681111 Na+/K+ -ATPase alpha 1 subunit isoform d [Homo
sapiens]
Length = 992
Score = 353 bits (905), Expect = 5e-97
Identities = 264/822 (32%), Positives = 401/822 (48%), Gaps = 90/822 (10%)
Query: 59 KCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLL 118
K ++L R + DL GL+ + G N + P W K+ Q +LL
Sbjct: 14 KLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLL 73
Query: 119 LGSALVSVLTKEYEDA-------------VSIATAVLVVVTVAFIQEYRSEKSLEELTKM 165
A++ L + A V ++ V++ ++ QE +S K +E M
Sbjct: 74 WIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNM 133
Query: 166 VPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEP 225
VP + +R G+ + A E+V GD+V + GDRIPAD+R+ VD SS TGE+EP
Sbjct: 134 VPQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEP 193
Query: 226 CSKTDSP-LTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPK 284
+T SP T L T NI F T G +G+V+ TG+ + G + + E +
Sbjct: 194 --QTRSPDFTNENPLET-RNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQ 250
Query: 285 TPLQKSMDRLGKQLT---LF---SFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEG 338
TP+ ++ +T +F SF I+ LI+ W + +F IG+ VA +PEG
Sbjct: 251 TPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAV----IFLIGI--IVANVPEG 304
Query: 339 LPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSD 398
L V V L L RMA+K +VK L VETLG S +CSDKTGTLT N MTV + +
Sbjct: 305 LLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDN 364
Query: 399 GLRA-----EVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVM 453
+ SGV +D L S+ I N +V + + N I K AV
Sbjct: 365 QIHEADTTENQSGVSFDKTSATWLALSR--IAGLCNRAVFQANQ-----ENLPILKRAVA 417
Query: 454 GQPTEGALMALAMKM--DLSDIKNSYIRKKEIPFSSEQKW-MAVKCSLKTEDQEDIYFMK 510
G +E AL+ + +++ Y + EIPF+S K+ +++ + T + + + MK
Sbjct: 418 GDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMK 477
Query: 511 GALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALA-------SGPE- 562
GA E ++ C+ G PL + + +G LG RVL PE
Sbjct: 478 GAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEG 537
Query: 563 -----------LGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIG 611
+ L F+GL+ +IDPPR V +AV +G+ V M+TGD TA AI
Sbjct: 538 FQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIA 597
Query: 612 RNIGLCN------------------------GKLQAMSGEEVDSVEKGELAD--RVGKVS 645
+ +G+ + K + G ++ + +L D +
Sbjct: 598 KGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHTEI 657
Query: 646 VFFRTSPKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANM 705
VF RTSP+ KL I++ Q GAIVA+TGDGVND+ ALK ADIG+AMG G+DVSK+AA+M
Sbjct: 658 VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADM 717
Query: 706 ILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQIL 765
IL+DD+F++I+ VEEG+ IF N+K + + L+++I ++ + + N+P PL + IL
Sbjct: 718 ILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTIL 777
Query: 766 WINIIMDGPPAQSLGVEPVDKDAFRQPPRSVR-DTILSRALI 806
I++ D PA SL E + D ++ PR+ + D +++ LI
Sbjct: 778 CIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLI 819
>gi|153946397 Na+/K+ -ATPase alpha 4 subunit isoform 1 [Homo
sapiens]
Length = 1029
Score = 345 bits (885), Expect = 1e-94
Identities = 260/850 (30%), Positives = 406/850 (47%), Gaps = 93/850 (10%)
Query: 30 EEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAH 89
++ ++ + + + +E+ KK + K E+L+ + VDL G S +
Sbjct: 27 KKKMVKREKQKRNMEELKKEVVMDDH---KLTLEELSTKYSVDLTKGHSHQRAKEILTRG 83
Query: 90 GWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDA-----------VSIA 138
G N + P W K+ Q LLL A++ + + +SI
Sbjct: 84 GPNTVTPPPTTPEWVKFCKQLFGGFSLLLWTGAILCFVAYSIQIYFNEEPTKDNLYLSIV 143
Query: 139 TAVLVVVTVAF--IQEYRSEKSLEELTKMVPPECNCLREGKLQHLLARELVPGDVVSLSI 196
+V+V+VT F QE +S K +E MVP + +R G+ + +E+V GD+V +
Sbjct: 144 LSVVVIVTGCFSYYQEAKSSKIMESFKNMVPQQALVIRGGEKMQINVQEVVLGDLVEIKG 203
Query: 197 GDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGR 256
GDR+PAD+RL VD SS TGE+EP S++ T L T NI F T G
Sbjct: 204 GDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPD-FTHENPLET-RNICFFSTNCVEGT 261
Query: 257 GQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFS------FGIIGLIM 310
+G+VI TG+S+ G + + +TP+ ++ +T+ + F + L++
Sbjct: 262 ARGIVIATGDSTVMGRIASLTSGLAVGQTPIAAEIEHFIHLITVVAVFLGVTFFALSLLL 321
Query: 311 LIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETL 370
GW + +F IG+ VA +PEGL V V L L RMA+K +VK L VETL
Sbjct: 322 GYGWLEA----IIFLIGI--IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETL 375
Query: 371 GCCSVLCSDKTGTLTANEMTVTQL-----VTSDGLRAEVSGVGYDGQGTVCLLPSKEVIK 425
G S +CSDKTGTLT N MTV + V E +G + + ++
Sbjct: 376 GSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTTEEQTGKTFTKSSDTWFMLAR---- 431
Query: 426 EFSNVSVGKLVEAGCVANNAV--IRKNAVMGQPTEGALMALAMKM--DLSDIKNSYIRKK 481
G A AN + I K A G +E AL+ + +++++ +
Sbjct: 432 -----IAGLCNRADFKANQEILPIAKRATTGDASESALLKFIEQSYSSVAEMREKNPKVA 486
Query: 482 EIPFSSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCL 541
EIPF+S K+ + Q + MKGA E ++ +C+ + G + + +
Sbjct: 487 EIPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMNDEMKEAFQ 546
Query: 542 QEEKRMGSLGLRVLA-----LASGPELG-------------RLTFLGLVGIIDPPRVGVK 583
+G LG RVL L S G L F+GL+ +IDPPR V
Sbjct: 547 NAYLELGGLGERVLGFCFLNLPSSFSKGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVP 606
Query: 584 EAVQVLSESGVSVKMITGDALETALAIGRNIGLCN------------------------G 619
+AV +G+ V M+TGD TA AI + +G+ +
Sbjct: 607 DAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISKVDASAA 666
Query: 620 KLQAMSGEEVDSVEKGELADRVGKVS--VFFRTSPKHKLKIIKALQESGAIVAMTGDGVN 677
K + G E+ ++ +L + VF RTSP+ KL I++ Q GA+VA+TGDGVN
Sbjct: 667 KAIVVHGAELKDIQSKQLDQILQNHPEIVFARTSPQQKLIIVEGCQRLGAVVAVTGDGVN 726
Query: 678 DAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQL 737
D+ ALK ADIGIAMG +G+DVSK+AA+MIL+DD+F++I+ VEEG+ IF N+K + + L
Sbjct: 727 DSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTL 786
Query: 738 STSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVR 797
+++I ++ + + +P PL + IL I++ D PA SL E + D ++ PR+ +
Sbjct: 787 TSNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPK 846
Query: 798 -DTILSRALI 806
D +++ LI
Sbjct: 847 TDNLVNHRLI 856
>gi|22748667 Na+/K+ -ATPase alpha 3 subunit [Homo sapiens]
Length = 1013
Score = 343 bits (880), Expect = 4e-94
Identities = 274/851 (32%), Positives = 409/851 (48%), Gaps = 108/851 (12%)
Query: 36 EQSELKAIEKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFV 95
E+ +L ++KE +T K E++ R + D GL+ + G N
Sbjct: 18 ERRDLDDLKKEVAMTEH------KMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALT 71
Query: 96 ADNSEPVWKKYLDQ-FKNPLILLLLGSALVSV---LTKEYEDAVS-------IATAVLVV 144
+ P W K+ Q F ILL +G+ L + + ED S I A +V+
Sbjct: 72 PPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVI 131
Query: 145 VTVAF--IQEYRSEKSLEELTKMVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPA 202
+T F QE +S K +E MVP + +REG+ + A E+V GD+V + GDR+PA
Sbjct: 132 ITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPA 191
Query: 203 DIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVI 262
D+R+ VD SS TGE+EP +T SP + NI F T G +GVV+
Sbjct: 192 DLRIISAHGCKVDNSSLTGESEP--QTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVV 249
Query: 263 GTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLT---LF---SFGIIGLIMLIGWSQ 316
TG+ + G + + E KTP+ ++ + +T +F SF I+ LI+ W +
Sbjct: 250 ATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLE 309
Query: 317 GKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVL 376
+F IG+ VA +PEGL V V L L RMA+K +VK L VETLG S +
Sbjct: 310 A----VIFLIGI--IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTI 363
Query: 377 CSDKTGTLTANEMTVTQL-----VTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVS 431
CSDKTGTLT N MTV + + + SG +D + S I N +
Sbjct: 364 CSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSH--IAGLCNRA 421
Query: 432 VGKLVEAGCVANNAVIRKNAVMGQPTEGALMALAMKMDLSDIKNSYIRKK---EIPFSSE 488
V K + +N + K V G +E AL+ +++ +K R K EIPF+S
Sbjct: 422 VFKGGQ-----DNIPVLKRDVAGDASESALLK-CIELSSGSVKLMRERNKKVAEIPFNST 475
Query: 489 QKW-MAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGIPLPLTPQQRSFCLQEEKRM 547
K+ +++ + D + MKGA E ++ C+ G PL + + +
Sbjct: 476 NKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLEL 535
Query: 548 GSLGLRVLALASG--PE-----------------LGRLTFLGLVGIIDPPRVGVKEAVQV 588
G LG RVL PE L F+GL+ +IDPPR V +AV
Sbjct: 536 GGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGK 595
Query: 589 LSESGVSVKMITGDALETALAIGRNIGLCN------------------------------ 618
+G+ V M+TGD TA AI + +G+ +
Sbjct: 596 CRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVI 655
Query: 619 --GKLQAMSGEEVDSVEKGELADRVGKVSVFFRTSPKHKLKIIKALQESGAIVAMTGDGV 676
L+ + E++D + + VF RTSP+ KL I++ Q GAIVA+TGDGV
Sbjct: 656 HGTDLKDFTSEQIDEILQNHTE------IVFARTSPQQKLIIVEGCQRQGAIVAVTGDGV 709
Query: 677 NDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQ 736
ND+ ALK ADIG+AMG G+DVSK+AA+MIL+DD+F++I+ VEEG+ IF N+K + +
Sbjct: 710 NDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYT 769
Query: 737 LSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSV 796
L+++I ++ L + N+P PL + IL I++ D PA SL E + D ++ PR+
Sbjct: 770 LTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNP 829
Query: 797 R-DTILSRALI 806
R D +++ LI
Sbjct: 830 RTDKLVNERLI 840
>gi|51944966 hydrogen/potassium-exchanging ATPase 4A [Homo sapiens]
Length = 1035
Score = 331 bits (848), Expect = 2e-90
Identities = 269/864 (31%), Positives = 405/864 (46%), Gaps = 101/864 (11%)
Query: 11 KKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFC 70
KK GGG++ + LE ++E I++ +L E E+K K
Sbjct: 29 KKKAGGGGGKRKEKLENMKKEMEINDH-QLSVAELEQKYQTSATK--------------- 72
Query: 71 VDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSV---- 126
GLS + L G N P + K+ Q L L+ +A + +
Sbjct: 73 -----GLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFA 127
Query: 127 -------LTKEYEDAVSIATAVLVVVTVAF--IQEYRSEKSLEELTKMVPPECNCLREGK 177
LT + ++IA +VVVT F QE++S + +VP + +R+G
Sbjct: 128 IQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGD 187
Query: 178 LQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGG 237
+ A +LV GD+V + GDR+PADIR+ VD SS TGE+EP +T SP
Sbjct: 188 KFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEP--QTRSPECTHE 245
Query: 238 DLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPL----QKSMDR 293
NI F T+ G QG+V+ TG+ + G + + E KTP+ + +D
Sbjct: 246 SPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDI 305
Query: 294 LGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLR 353
+ LF + M IG++ L +++ VA +PEGL V V L L R
Sbjct: 306 IAGLAILFGATFFIVAMCIGYT----FLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKR 361
Query: 354 MAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQG 413
+A K +VK L VETLG SV+CSDKTGTLT N MTV+ L + + + GQ
Sbjct: 362 LASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQ- 420
Query: 414 TVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAV-IRKNAVMGQPTEGALMALAMKMDLSD 472
S E + V A +AV + K V+G +E AL+ + ++ L +
Sbjct: 421 --TFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFS-ELTLGN 477
Query: 473 I---KNSYIRKKEIPFSSEQKW-MAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNGGI 528
++ + + EIPF+S K+ +++ D + MKGA E V+ C+ G
Sbjct: 478 AMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQ 537
Query: 529 PLPLTPQQRSFCLQEEKRMGSLGLRVLALA--------------------SGPELGRLTF 568
LPL Q R +G LG RVL + P G L F
Sbjct: 538 ELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSG-LCF 596
Query: 569 LGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLCN---------- 618
GLV +IDPPR V +AV +G+ V M+TGD TA AI ++G+ +
Sbjct: 597 AGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIA 656
Query: 619 --------------GKLQAMSGEEVDSVEKGELAD--RVGKVSVFFRTSPKHKLKIIKAL 662
+ ++G ++ ++ EL + R VF RTSP+ KL I+++
Sbjct: 657 ARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESC 716
Query: 663 QESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDDFSAIMNAVEEG 722
Q GAIVA+TGDGVND+ ALK ADIG+AMG G+D +K AA+MIL+DD+F++I+ VE+G
Sbjct: 717 QRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQG 776
Query: 723 KGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIMDGPPAQSLGVE 782
+ IF N+K + + L+ +I L+ + ++P PL + IL+I + D P+ SL E
Sbjct: 777 RLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYE 836
Query: 783 PVDKDAFRQPPRS-VRDTILSRAL 805
+ D PR+ RD +++ L
Sbjct: 837 KAESDIMHLRPRNPKRDRLVNEPL 860
>gi|83700225 hydrogen/potassium-exchanging ATPase 12A [Homo sapiens]
Length = 1039
Score = 324 bits (831), Expect = 2e-88
Identities = 254/848 (29%), Positives = 392/848 (46%), Gaps = 78/848 (9%)
Query: 59 KCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPL-ILL 117
K +L + D+ GLS + G N P K+L Q ILL
Sbjct: 60 KLSNRELEEKYGTDIIMGLSSTRAAELLARDGPNSLTPPKQTPEIVKFLKQMVGGFSILL 119
Query: 118 LLGSALVSV-------------LTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTK 164
+G+ L + L Y V + V++ A+ QE +S + K
Sbjct: 120 WVGAFLCWIAYGIQYSSDKSASLNNVYLGCV-LGLVVILTGIFAYYQEAKSTNIMSSFNK 178
Query: 165 MVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAE 224
M+P + +R+ + + + + +LV GD+V + GD+IPADIR+ VD SS TGE+E
Sbjct: 179 MIPQQALVIRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGESE 238
Query: 225 PCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPK 284
P ++ S T L T NI F T G G+VI TG+ + G + + K
Sbjct: 239 PQPRS-SEFTHENPLET-KNICFYSTTCLEGTVTGMVINTGDRTIIGHIASLASGVGNEK 296
Query: 285 TPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQLLSMFTIGVSLAVAAIPEGLPIVVM 344
TP+ ++ + + I L +I S Q+L + + VA +PEGL V
Sbjct: 297 TPIAIEIEHFVHIVAGVAVSIGILFFIIAVSLKYQVLDSIIFLIGIIVANVPEGLLATVT 356
Query: 345 VTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDKTGTLTANEMTVTQLVTSDGLRAEV 404
VTL L RMAKK +VK L VETLG S++CSDKTGTLT N MTV L + + V
Sbjct: 357 VTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIF--V 414
Query: 405 SGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGCVANNAVIRKNAVMGQPTEGALMAL 464
+ D V S+ +++ E N I K AV+G +E AL+
Sbjct: 415 ADTSEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKF 474
Query: 465 AMKM--DLSDIKNSYIRKKEIPFSSEQKWMAVKCSLKTEDQED------IYFMKGALEEV 516
+ + D+ +I+ + EIPF+S K+ L + +D + MKGA E +
Sbjct: 475 SEVILGDVMEIRKRNRKVAEIPFNSTNKFQ-----LSIHEMDDPHGKRFLMVMKGAPERI 529
Query: 517 IRYCTMYNNGGIPLPLTPQQRSFCLQEEKRMGSLGLRVLALA-------SGPEL------ 563
+ C+ G PL +G LG RVL PE
Sbjct: 530 LEKCSTIMINGEEHPLDKSTAKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDID 589
Query: 564 ------GRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMITGDALETALAIGRNIGLC 617
L F+GL+ +IDPPR V +AV +G+ V M+TGD TA AI +++G+
Sbjct: 590 AMNFPTSNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGII 649
Query: 618 NG------------------------KLQAMSGEEVDSVEKGELADRVGKVS--VFFRTS 651
+ K ++G E+ + +L + + VF RTS
Sbjct: 650 SANSETVEDIAHRLNIAVEQVNKRDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTS 709
Query: 652 PKHKLKIIKALQESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAANMILVDDD 711
P+ KL I++ Q A+VA+TGDGVND+ ALK ADIGIAMG G+D +K AA+M+L+DD+
Sbjct: 710 PQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDN 769
Query: 712 FSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQILWINIIM 771
F++I+ VEEG+ IF N+K + + L+ +I+ L + + LP P+ + IL+I++
Sbjct: 770 FASIVTGVEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGT 829
Query: 772 DGPPAQSLGVEPVDKDAFRQPPR-SVRDTILSRALILKILMSAAIIISGTLFIFWKEMPE 830
D P+ +L E + D + PR +D ++++ L + + ++ + F+ + +
Sbjct: 830 DIIPSIALAYEKAESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYA 889
Query: 831 DRASTPRT 838
PRT
Sbjct: 890 QEGFLPRT 897
>gi|48255949 plasma membrane calcium ATPase 2 isoform 2 [Homo sapiens]
Length = 1198
Score = 283 bits (723), Expect = 7e-76
Identities = 246/862 (28%), Positives = 399/862 (46%), Gaps = 116/862 (13%)
Query: 133 DAVSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPE--CNCLREGKLQHLLARELVPGD 190
+ +I +V+ VV V ++ EK L + E +R G++ + E+V GD
Sbjct: 153 EGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGD 212
Query: 191 VVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKT---DSPLTGGGDLTTLSNIVF 247
+ + GD +PAD + DL +DESS TGE++ K+ D L G + S +
Sbjct: 213 IAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRML 272
Query: 248 MGTLVQYGRGQGVV---IGTG-------------------------ESSQFGEVFKMMQA 279
+ T V G++ +G G +S++ G+ +A
Sbjct: 273 V-TAVGVNSQTGIIFTLLGAGGEEEEKKDKKAKQQDGAAAMEMQPLKSAEGGDADDRKKA 331
Query: 280 E--ETPKTPLQKSMDRLGKQLT---LFSFGIIGLIMLIGWSQG----------------- 317
+ K+ LQ + +L Q+ L I +I+++ ++
Sbjct: 332 SMHKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFTVDTFVVNKKPWLPECTPVY 391
Query: 318 -KQLLSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVL 376
+ + F IGV++ V A+PEGLP+ V ++L V +M K +V+ L ET+G + +
Sbjct: 392 VQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAI 451
Query: 377 CSDKTGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLV 436
CSDKTGTLT N MTV Q D E+ T+ LL + I +
Sbjct: 452 CSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPE 511
Query: 437 EAGCVANNAVIRKNAVMGQPTEGALMA--LAMKMDLSDIKNSYIRKK---EIPFSSEQKW 491
+ G + +G TE L+ L +K D +++ +K F+S +K
Sbjct: 512 KEGALPRQ--------VGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKS 563
Query: 492 MAVKCSLKTEDQEDIYFMKGALEEVIRYCTMYNNG-GIPLPLTPQQRSFCLQEE-KRMGS 549
M+ +K D+ + KGA E V++ C NG G P P+ R +++ + M
Sbjct: 564 MSTV--IKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMAC 621
Query: 550 LGLRVLALA-----SGPE---------LGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVS 595
GLR + +A S PE L LT + +VGI DP R V EA++ +G++
Sbjct: 622 DGLRTICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGIT 681
Query: 596 VKMITGDALETALAIGRNIGLCNG--KLQAMSGEEVDSV---EKGELA-DRVGKV----S 645
V+M+TGD + TA AI G+ + + G+E + EKGE+ +R+ K+
Sbjct: 682 VRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLR 741
Query: 646 VFFRTSPKHKLKIIKAL-----QESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSK 700
V R+SP K ++K + E +VA+TGDG ND ALK AD+G AMG GTDV+K
Sbjct: 742 VLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAK 801
Query: 701 EAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLN 760
EA+++IL DD+FS+I+ AV G+ ++ +I F++FQL+ ++ A+ + SPL
Sbjct: 802 EASDIILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLK 861
Query: 761 AMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAA---III 817
A+Q+LW+N+IMD + +L EP + + P ++SR ++ IL A +I
Sbjct: 862 AVQMLWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALI 921
Query: 818 SGTLFIFWKEMPED-------RASTPRTTTMTFTCFVFFDLFNALTCRS--QTKLIFEIG 868
LF+ K D + T+ F FV LFN + R + +F+ G
Sbjct: 922 FTLLFVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFD-G 980
Query: 869 FLRNHMFLYSVLGSILGQLAVI 890
RN +F VLG+ Q+ ++
Sbjct: 981 IFRNPIFCTIVLGTFAIQIVIV 1002
>gi|48255951 plasma membrane calcium ATPase 2 isoform 1 [Homo sapiens]
Length = 1243
Score = 256 bits (653), Expect = 9e-68
Identities = 196/618 (31%), Positives = 306/618 (49%), Gaps = 59/618 (9%)
Query: 321 LSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDK 380
+ F IGV++ V A+PEGLP+ V ++L V +M K +V+ L ET+G + +CSDK
Sbjct: 441 VKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 500
Query: 381 TGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGC 440
TGTLT N MTV Q D E+ T+ LL + I + + G
Sbjct: 501 TGTLTTNRMTVVQAYVGDVHYKEIPDPSSINTKTMELLINAIAINSAYTTKILPPEKEGA 560
Query: 441 VANNAVIRKNAVMGQPTEGALMA--LAMKMDLSDIKNSYIRKK---EIPFSSEQKWMAVK 495
+ +G TE L+ L +K D +++ +K F+S +K M+
Sbjct: 561 LPRQ--------VGNKTECGLLGFVLDLKQDYEPVRSQMPEEKLYKVYTFNSVRKSMSTV 612
Query: 496 CSLKTEDQEDIYFMKGALEEVIRYCTMYNNG-GIPLPLTPQQRSFCLQEE-KRMGSLGLR 553
+K D+ + KGA E V++ C NG G P P+ R +++ + M GLR
Sbjct: 613 --IKLPDESFRMYSKGASEIVLKKCCKILNGAGEPRVFRPRDRDEMVKKVIEPMACDGLR 670
Query: 554 VLALA-----SGPE---------LGRLTFLGLVGIIDPPRVGVKEAVQVLSESGVSVKMI 599
+ +A S PE L LT + +VGI DP R V EA++ +G++V+M+
Sbjct: 671 TICVAYRDFPSSPEPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKCQRAGITVRMV 730
Query: 600 TGDALETALAIGRNIGLCNG--KLQAMSGEEVDSV---EKGELA-DRVGKV----SVFFR 649
TGD + TA AI G+ + + G+E + EKGE+ +R+ K+ V R
Sbjct: 731 TGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLAR 790
Query: 650 TSPKHKLKIIKAL-----QESGAIVAMTGDGVNDAVALKSADIGIAMGQTGTDVSKEAAN 704
+SP K ++K + E +VA+TGDG ND ALK AD+G AMG GTDV+KEA++
Sbjct: 791 SSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASD 850
Query: 705 MILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPSPLNAMQI 764
+IL DD+FS+I+ AV G+ ++ +I F++FQL+ ++ A+ + SPL A+Q+
Sbjct: 851 IILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQM 910
Query: 765 LWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSAA---IIISGTL 821
LW+N+IMD + +L EP + + P ++SR ++ IL A +I L
Sbjct: 911 LWVNLIMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLALIFTLL 970
Query: 822 FIFWKEMPED-------RASTPRTTTMTFTCFVFFDLFNALTCRS--QTKLIFEIGFLRN 872
F+ K D + T+ F FV LFN + R + +F+ G RN
Sbjct: 971 FVGEKMFQIDSGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFD-GIFRN 1029
Query: 873 HMFLYSVLGSILGQLAVI 890
+F VLG+ Q+ ++
Sbjct: 1030 PIFCTIVLGTFAIQIVIV 1047
Score = 64.7 bits (156), Expect = 4e-10
Identities = 42/149 (28%), Positives = 70/149 (46%), Gaps = 12/149 (8%)
Query: 133 DAVSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPE--CNCLREGKLQHLLARELVPGD 190
+ +I +V+ VV V ++ EK L + E +R G++ + E+V GD
Sbjct: 153 EGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGD 212
Query: 191 VVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGT 250
+ + GD +PAD + DL +DESS TGE++ K+ ++ GT
Sbjct: 213 IAQVKYGDLLPADGLFIQGNDLKIDESSLTGESDQVRKS----------VDKDPMLLSGT 262
Query: 251 LVQYGRGQGVVIGTGESSQFGEVFKMMQA 279
V G G+ +V G +SQ G +F ++ A
Sbjct: 263 HVMEGSGRMLVTAVGVNSQTGIIFTLLGA 291
>gi|48255947 plasma membrane calcium ATPase 1 isoform 1a [Homo
sapiens]
Length = 1176
Score = 248 bits (632), Expect = 2e-65
Identities = 194/625 (31%), Positives = 304/625 (48%), Gaps = 72/625 (11%)
Query: 321 LSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDK 380
+ F IGV++ V A+PEGLP+ V ++L V +M K +V+ L ET+G + +CSDK
Sbjct: 417 VKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 476
Query: 381 TGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGC 440
TGTLT N MTV Q ++ +V P E I + + C
Sbjct: 477 TGTLTMNRMTVVQAYINEKHYKKV--------------PEPEAIPPNILSYLVTGISVNC 522
Query: 441 VANNAVIRKNAVMGQP------TEGALMALAM--KMDLSDIKNSYIRK---KEIPFSSEQ 489
+ ++ G P TE AL+ L + K D D++N + K F+S +
Sbjct: 523 AYTSKILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVR 582
Query: 490 KWMAVKCSLKTEDQEDIYFMKGALEEVIRYC-TMYNNGGIPLPLTPQQRSFCLQEE-KRM 547
K M+ LK D F KGA E +++ C + + G P+ R ++ + M
Sbjct: 583 KSMSTV--LKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPM 640
Query: 548 GSLGLRVLALA------SGPE---------LGRLTFLGLVGIIDPPRVGVKEAVQVLSES 592
S GLR + LA PE + LT + +VGI DP R V +A++ +
Sbjct: 641 ASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRA 700
Query: 593 GVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVD-----SVEKGELA-DRVGKV-- 644
G++V+M+TGD + TA AI G+ + + E D EKGE+ +R+ K+
Sbjct: 701 GITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWP 760
Query: 645 --SVFFRTSPKHKLKIIKALQESGA-----IVAMTGDGVNDAVALKSADIGIAMGQTGTD 697
V R+SP K ++K + +S +VA+TGDG ND ALK AD+G AMG GTD
Sbjct: 761 KLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTD 820
Query: 698 VSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPS 757
V+KEA+++IL DD+F++I+ AV G+ ++ +I F++FQL+ ++ A+ + S
Sbjct: 821 VAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS 880
Query: 758 PLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSA---A 814
PL A+Q+LW+N+IMD + +L EP + + P ++SR ++ IL A
Sbjct: 881 PLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQL 940
Query: 815 IIISGTLFIFWKEMPED-------RASTPRTTTMTFTCFVFFDLFNALTCRS--QTKLIF 865
+++ LF K D A T+ F FV LFN + R + +F
Sbjct: 941 VVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVF 1000
Query: 866 EIGFLRNHMFLYSVLGSILGQLAVI 890
E G N +F VLG+ + Q+ ++
Sbjct: 1001 E-GIFNNAIFCTIVLGTFVVQIIIV 1024
Score = 65.5 bits (158), Expect = 2e-10
Identities = 48/169 (28%), Positives = 78/169 (46%), Gaps = 14/169 (8%)
Query: 133 DAVSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPE--CNCLREGKLQHLLARELVPGD 190
+ +I +V+ VV V ++ EK L + E +R G++ + ++ GD
Sbjct: 155 EGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGD 214
Query: 191 VVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGT 250
+ + GD +PAD L + DL +DESS TGE++ K+ ++ GT
Sbjct: 215 IAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS----------LDKDPLLLSGT 264
Query: 251 LVQYGRGQGVVIGTGESSQFGEVFKMMQA--EETPKTPLQKSMDRLGKQ 297
V G G+ VV G +SQ G +F ++ A EE K +K + KQ
Sbjct: 265 HVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQ 313
>gi|48255945 plasma membrane calcium ATPase 1 isoform 1b [Homo
sapiens]
Length = 1220
Score = 248 bits (632), Expect = 2e-65
Identities = 194/625 (31%), Positives = 304/625 (48%), Gaps = 72/625 (11%)
Query: 321 LSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDK 380
+ F IGV++ V A+PEGLP+ V ++L V +M K +V+ L ET+G + +CSDK
Sbjct: 417 VKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 476
Query: 381 TGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGC 440
TGTLT N MTV Q ++ +V P E I + + C
Sbjct: 477 TGTLTMNRMTVVQAYINEKHYKKV--------------PEPEAIPPNILSYLVTGISVNC 522
Query: 441 VANNAVIRKNAVMGQP------TEGALMALAM--KMDLSDIKNSYIRK---KEIPFSSEQ 489
+ ++ G P TE AL+ L + K D D++N + K F+S +
Sbjct: 523 AYTSKILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEALYKVYTFNSVR 582
Query: 490 KWMAVKCSLKTEDQEDIYFMKGALEEVIRYC-TMYNNGGIPLPLTPQQRSFCLQEE-KRM 547
K M+ LK D F KGA E +++ C + + G P+ R ++ + M
Sbjct: 583 KSMSTV--LKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPM 640
Query: 548 GSLGLRVLALA------SGPE---------LGRLTFLGLVGIIDPPRVGVKEAVQVLSES 592
S GLR + LA PE + LT + +VGI DP R V +A++ +
Sbjct: 641 ASEGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRA 700
Query: 593 GVSVKMITGDALETALAIGRNIGLCNGKLQAMSGEEVD-----SVEKGELA-DRVGKV-- 644
G++V+M+TGD + TA AI G+ + + E D EKGE+ +R+ K+
Sbjct: 701 GITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWP 760
Query: 645 --SVFFRTSPKHKLKIIKALQESGA-----IVAMTGDGVNDAVALKSADIGIAMGQTGTD 697
V R+SP K ++K + +S +VA+TGDG ND ALK AD+G AMG GTD
Sbjct: 761 KLRVLARSSPTDKHTLVKGIIDSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTD 820
Query: 698 VSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNLPS 757
V+KEA+++IL DD+F++I+ AV G+ ++ +I F++FQL+ ++ A+ + S
Sbjct: 821 VAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS 880
Query: 758 PLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSA---A 814
PL A+Q+LW+N+IMD + +L EP + + P ++SR ++ IL A
Sbjct: 881 PLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQL 940
Query: 815 IIISGTLFIFWKEMPED-------RASTPRTTTMTFTCFVFFDLFNALTCRS--QTKLIF 865
+++ LF K D A T+ F FV LFN + R + +F
Sbjct: 941 VVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVF 1000
Query: 866 EIGFLRNHMFLYSVLGSILGQLAVI 890
E G N +F VLG+ + Q+ ++
Sbjct: 1001 E-GIFNNAIFCTIVLGTFVVQIIIV 1024
Score = 65.5 bits (158), Expect = 2e-10
Identities = 48/169 (28%), Positives = 78/169 (46%), Gaps = 14/169 (8%)
Query: 133 DAVSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPE--CNCLREGKLQHLLARELVPGD 190
+ +I +V+ VV V ++ EK L + E +R G++ + ++ GD
Sbjct: 155 EGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGD 214
Query: 191 VVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGT 250
+ + GD +PAD L + DL +DESS TGE++ K+ ++ GT
Sbjct: 215 IAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS----------LDKDPLLLSGT 264
Query: 251 LVQYGRGQGVVIGTGESSQFGEVFKMMQA--EETPKTPLQKSMDRLGKQ 297
V G G+ VV G +SQ G +F ++ A EE K +K + KQ
Sbjct: 265 HVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGEEEEKKDEKKKEKKNKKQ 313
>gi|48255959 plasma membrane calcium ATPase 4 isoform 4a [Homo
sapiens]
Length = 1170
Score = 243 bits (620), Expect = 6e-64
Identities = 190/627 (30%), Positives = 309/627 (49%), Gaps = 78/627 (12%)
Query: 321 LSMFTIGVSLAVAAIPEGLPIVVMVTLVLGVLRMAKKRVIVKKLPIVETLGCCSVLCSDK 380
+ F IG+++ V A+PEGLP+ V ++L V +M K +V+ L ET+G + +CSDK
Sbjct: 407 VKFFIIGITVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 466
Query: 381 TGTLTANEMTVTQLVTSDGLRAEVSGVGYDGQGTVCLLPSKEVIKEFSNVSVGKLVEAGC 440
TGTLT N MTV Q A + G+ Y +PS +V V L+ G
Sbjct: 467 TGTLTMNRMTVVQ--------AYIGGIHYRQ------IPSPDVFLP----KVLDLIVNGI 508
Query: 441 VANNAVIRK----------NAVMGQPTEGALMALA--MKMDLSDIKNSYIRKK---EIPF 485
N+A K +G TE AL+ +K D ++N +K F
Sbjct: 509 SINSAYTSKILPPEKEGGLPRQVGNKTECALLGFVTDLKQDYQAVRNEVPEEKLYKVYTF 568
Query: 486 SSEQKWMAVKCSLKTEDQEDIYFMKGALEEVIRYCT-MYNNGGIPLPLTPQQRSFCLQEE 544
+S +K M+ ++ + + KGA E ++R C + + G +P + R ++
Sbjct: 569 NSVRKSMSTV--IRNPNGGFRMYSKGASEIILRKCNRILDRKGEAVPFKNKDRDDMVRTV 626
Query: 545 -KRMGSLGLRVLALA-------------SGPELGRLTFLGLVGIIDPPRVGVKEAVQVLS 590
+ M GLR + +A L LT + +VGI DP R V +A+
Sbjct: 627 IEPMACDGLRTICIAYRDFDDTEPSWDNENEILTELTCIAVVGIEDPVRPEVPDAIAKCK 686
Query: 591 ESGVSVKMITGDALETALAIGRNIGLCN--GKLQAMSGEEVDSV---EKGELA----DRV 641
++G++V+M+TGD + TA AI G+ + G+E + + EKGE+ D++
Sbjct: 687 QAGITVRMVTGDNINTARAIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKI 746
Query: 642 G-KVSVFFRTSPKHKLKIIKALQESGA-----IVAMTGDGVNDAVALKSADIGIAMGQTG 695
K+ V R+SP K ++K + +S +VA+TGDG ND ALK AD+G AMG G
Sbjct: 747 WPKLRVLARSSPTDKHTLVKGIIDSTVGEHRQVVAVTGDGTNDGPALKKADVGFAMGIAG 806
Query: 696 TDVSKEAANMILVDDDFSAIMNAVEEGKGIFYNIKNFVRFQLSTSISALSLITLSTVFNL 755
TDV+KEA+++IL DD+F++I+ AV G+ ++ +I F++FQL+ ++ A+ +
Sbjct: 807 TDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQ 866
Query: 756 PSPLNAMQILWINIIMDGPPAQSLGVEPVDKDAFRQPPRSVRDTILSRALILKILMSA-- 813
SPL A+Q+LW+N+IMD + +L EP + ++ P ++SR ++ IL A
Sbjct: 867 DSPLKAVQMLWVNLIMDTFASLALATEPPTESLLKRRPYGRNKPLISRTMMKNILGHAFY 926
Query: 814 ------AIIISGTLFIFWKEMPEDRASTPRTT--TMTFTCFVFFDLFNALTCRS--QTKL 863
++ +G F + +P + T+ F FV LFN + R K
Sbjct: 927 QLIVIFILVFAGEKFFDIDSGRKAPLHSPPSQHYTIVFNTFVLMQLFNEINSRKIHGEKN 986
Query: 864 IFEIGFLRNHMFLYSVLGSILGQLAVI 890
+F G RN +F VLG+ + Q+ ++
Sbjct: 987 VFS-GIYRNIIFCSVVLGTFICQIFIV 1012
Score = 68.2 bits (165), Expect = 4e-11
Identities = 47/165 (28%), Positives = 77/165 (46%), Gaps = 12/165 (7%)
Query: 133 DAVSIATAVLVVVTVAFIQEYRSEKSLEELTKMVPPE--CNCLREGKLQHLLARELVPGD 190
+ +I +V++VV V ++ EK L + E + +R G+L L E+V GD
Sbjct: 151 EGAAILFSVIIVVLVTAFNDWSKEKQFRGLQCRIEQEQKFSIIRNGQLIQLPVAEIVVGD 210
Query: 191 VVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGT 250
+ + GD +PAD L + DL +DESS TGE++ K+ ++ GT
Sbjct: 211 IAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS----------LDKDPMLLSGT 260
Query: 251 LVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLG 295
V G G+ VV G +SQ G + ++ E + +K + G
Sbjct: 261 HVMEGSGRMVVTAVGVNSQTGIILTLLGVNEDDEGEKKKKGKKQG 305
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,923,220
Number of Sequences: 37866
Number of extensions: 1396224
Number of successful extensions: 4191
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 3834
Number of HSP's gapped (non-prelim): 146
length of query: 946
length of database: 18,247,518
effective HSP length: 112
effective length of query: 834
effective length of database: 14,006,526
effective search space: 11681442684
effective search space used: 11681442684
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.