BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|10862703 ret proto-oncogene isoform a [Homo sapiens] (1114 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|10862703 ret proto-oncogene isoform a [Homo sapiens] 2279 0.0 gi|10862701 ret proto-oncogene isoform c [Homo sapiens] 2170 0.0 gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 330 5e-90 gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 329 8e-90 gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 329 8e-90 gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 329 8e-90 gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 329 8e-90 gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 329 8e-90 gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 328 2e-89 gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 328 2e-89 gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 328 2e-89 gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 328 2e-89 gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 328 2e-89 gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 328 2e-89 gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 328 2e-89 gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 324 3e-88 gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 324 3e-88 gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 324 3e-88 gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 321 2e-87 gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 321 2e-87 gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 320 5e-87 gi|11321597 kinase insert domain receptor precursor [Homo sapiens] 274 4e-73 gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur... 273 5e-73 gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 259 8e-69 gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap... 244 4e-64 gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 234 4e-61 gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 230 5e-60 gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 223 1e-57 gi|31657140 insulin receptor-related receptor precursor [Homo sa... 221 3e-57 gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 220 7e-57 >gi|10862703 ret proto-oncogene isoform a [Homo sapiens] Length = 1114 Score = 2279 bits (5907), Expect = 0.0 Identities = 1114/1114 (100%), Positives = 1114/1114 (100%) Query: 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP 60 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP Sbjct: 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP 60 Query: 61 EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT 120 EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT Sbjct: 61 EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT 120 Query: 121 VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR 180 VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR Sbjct: 121 VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR 180 Query: 181 PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV 240 PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV Sbjct: 181 PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV 240 Query: 241 AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD 300 AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD Sbjct: 241 AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD 300 Query: 301 ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR 360 ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR Sbjct: 301 ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR 360 Query: 361 NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA 420 NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA Sbjct: 361 NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA 420 Query: 421 QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE 480 QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE Sbjct: 421 QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE 480 Query: 481 LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR 540 LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR Sbjct: 481 LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR 540 Query: 541 CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR 600 CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR Sbjct: 541 CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR 600 Query: 601 GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY 660 GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY Sbjct: 601 GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY 660 Query: 661 HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP 720 HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP Sbjct: 661 HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP 720 Query: 721 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 780 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK Sbjct: 721 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 780 Query: 781 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 840 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH Sbjct: 781 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 840 Query: 841 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 900 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY Sbjct: 841 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 900 Query: 901 EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 960 EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL Sbjct: 901 EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 960 Query: 961 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA 1020 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA Sbjct: 961 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA 1020 Query: 1021 STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRA 1080 STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRA Sbjct: 1021 STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRA 1080 Query: 1081 DGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS 1114 DGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS Sbjct: 1081 DGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS 1114 >gi|10862701 ret proto-oncogene isoform c [Homo sapiens] Length = 1072 Score = 2170 bits (5623), Expect = 0.0 Identities = 1063/1063 (100%), Positives = 1063/1063 (100%) Query: 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP 60 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP Sbjct: 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP 60 Query: 61 EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT 120 EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT Sbjct: 61 EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT 120 Query: 121 VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR 180 VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR Sbjct: 121 VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR 180 Query: 181 PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV 240 PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV Sbjct: 181 PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV 240 Query: 241 AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD 300 AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD Sbjct: 241 AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD 300 Query: 301 ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR 360 ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR Sbjct: 301 ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR 360 Query: 361 NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA 420 NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA Sbjct: 361 NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA 420 Query: 421 QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE 480 QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE Sbjct: 421 QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE 480 Query: 481 LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR 540 LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR Sbjct: 481 LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR 540 Query: 541 CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR 600 CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR Sbjct: 541 CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR 600 Query: 601 GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY 660 GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY Sbjct: 601 GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY 660 Query: 661 HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP 720 HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP Sbjct: 661 HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP 720 Query: 721 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 780 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK Sbjct: 721 RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 780 Query: 781 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 840 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH Sbjct: 781 QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 840 Query: 841 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 900 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY Sbjct: 841 PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 900 Query: 901 EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 960 EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL Sbjct: 901 EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 960 Query: 961 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA 1020 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA Sbjct: 961 FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA 1020 Query: 1021 STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYG 1063 STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYG Sbjct: 1021 STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYG 1063 >gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor [Homo sapiens] Length = 704 Score = 330 bits (846), Expect = 5e-90 Identities = 180/384 (46%), Positives = 238/384 (61%), Gaps = 29/384 (7%) Query: 661 HKFAHKPPI-------SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILE 713 HK + P+ SS+ M P SS+ A P L V +++ E Sbjct: 301 HKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPE 353 Query: 714 DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELR 770 DPKWEFPR L LGK LGEG FG+VV A A + K + TVAVKMLK++A+ +L Sbjct: 354 DPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLS 412 Query: 771 DLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 829 DL+SE ++K + H ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y Sbjct: 413 DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--- 469 Query: 830 GGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMK 889 S ++ E +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MK Sbjct: 470 -----SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK 524 Query: 890 ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 949 I+DFGL+RD+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG Sbjct: 525 IADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG 584 Query: 950 NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM- 1008 +PYPGIP E LF LLK GHRM++P NC+ E+Y +M CW P +RP F + +DL+++ Sbjct: 585 SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 644 Query: 1009 -MVKRRDYLDLAASTPSDSLIYDD 1031 + +YLDL+ S Y D Sbjct: 645 TLTTNEEYLDLSQPLEQYSPSYPD 668 >gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor [Homo sapiens] Length = 705 Score = 329 bits (844), Expect = 8e-90 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%) Query: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729 SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK Sbjct: 318 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 370 Query: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785 LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H Sbjct: 371 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 429 Query: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845 ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E Sbjct: 430 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 481 Query: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905 +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y Sbjct: 482 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 541 Query: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965 K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK Sbjct: 542 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 601 Query: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023 GHRM++P NC+ E+Y +M CW P +RP F + +DL+++ + +YLDL+ Sbjct: 602 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 661 Query: 1024 SDSLIYDD 1031 S Y D Sbjct: 662 QYSPSYPD 669 >gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor [Homo sapiens] Length = 706 Score = 329 bits (844), Expect = 8e-90 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%) Query: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729 SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK Sbjct: 319 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 371 Query: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785 LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H Sbjct: 372 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 430 Query: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845 ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E Sbjct: 431 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 482 Query: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905 +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y Sbjct: 483 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 542 Query: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965 K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK Sbjct: 543 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 602 Query: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023 GHRM++P NC+ E+Y +M CW P +RP F + +DL+++ + +YLDL+ Sbjct: 603 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 662 Query: 1024 SDSLIYDD 1031 S Y D Sbjct: 663 QYSPSYPD 670 >gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor [Homo sapiens] Length = 709 Score = 329 bits (844), Expect = 8e-90 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%) Query: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729 SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK Sbjct: 322 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 374 Query: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785 LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H Sbjct: 375 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 433 Query: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845 ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E Sbjct: 434 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 485 Query: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905 +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y Sbjct: 486 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 545 Query: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965 K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK Sbjct: 546 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 605 Query: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023 GHRM++P NC+ E+Y +M CW P +RP F + +DL+++ + +YLDL+ Sbjct: 606 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 665 Query: 1024 SDSLIYDD 1031 S Y D Sbjct: 666 QYSPSYPD 673 >gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor [Homo sapiens] Length = 821 Score = 329 bits (844), Expect = 8e-90 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%) Query: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729 SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK Sbjct: 434 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 486 Query: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785 LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H Sbjct: 487 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 545 Query: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845 ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E Sbjct: 546 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 597 Query: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905 +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y Sbjct: 598 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 657 Query: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965 K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK Sbjct: 658 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 717 Query: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023 GHRM++P NC+ E+Y +M CW P +RP F + +DL+++ + +YLDL+ Sbjct: 718 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 777 Query: 1024 SDSLIYDD 1031 S Y D Sbjct: 778 QYSPSYPD 785 >gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor [Homo sapiens] Length = 822 Score = 329 bits (844), Expect = 8e-90 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%) Query: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729 SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK Sbjct: 435 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 487 Query: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785 LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H Sbjct: 488 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 546 Query: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845 ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E Sbjct: 547 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 598 Query: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905 +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y Sbjct: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658 Query: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965 K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK Sbjct: 659 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 718 Query: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023 GHRM++P NC+ E+Y +M CW P +RP F + +DL+++ + +YLDL+ Sbjct: 719 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 778 Query: 1024 SDSLIYDD 1031 S Y D Sbjct: 779 QYSPSYPD 786 >gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor [Homo sapiens] Length = 808 Score = 328 bits (840), Expect = 2e-89 Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%) Query: 705 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762 +V ++ DPKWE R L LGK LGEG FG+VV A A + K RA TVAVKMLK+ Sbjct: 455 NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 514 Query: 763 NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821 +A+ +L DL+SE ++K + H ++I L GAC+Q GPL ++VEYA G+LR FLR R Sbjct: 515 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 574 Query: 822 VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881 G Y S P E LT DL+S A+Q+++GM+YLA K +HRDLAARN+L Sbjct: 575 PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 626 Query: 882 VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941 V E MKI+DFGL+RDV+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL Sbjct: 627 VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 686 Query: 942 WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001 WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW P +RP F + Sbjct: 687 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 746 Query: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033 +DL++++ +YLDL+A TPS S DD + Sbjct: 747 VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 790 >gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor [Homo sapiens] Length = 694 Score = 328 bits (840), Expect = 2e-89 Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%) Query: 705 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762 +V ++ DPKWE R L LGK LGEG FG+VV A A + K RA TVAVKMLK+ Sbjct: 341 NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 400 Query: 763 NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821 +A+ +L DL+SE ++K + H ++I L GAC+Q GPL ++VEYA G+LR FLR R Sbjct: 401 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 460 Query: 822 VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881 G Y S P E LT DL+S A+Q+++GM+YLA K +HRDLAARN+L Sbjct: 461 PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 512 Query: 882 VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941 V E MKI+DFGL+RDV+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL Sbjct: 513 VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 572 Query: 942 WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001 WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW P +RP F + Sbjct: 573 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 632 Query: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033 +DL++++ +YLDL+A TPS S DD + Sbjct: 633 VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 676 >gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor [Homo sapiens] Length = 806 Score = 328 bits (840), Expect = 2e-89 Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%) Query: 705 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762 +V ++ DPKWE R L LGK LGEG FG+VV A A + K RA TVAVKMLK+ Sbjct: 453 NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 512 Query: 763 NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821 +A+ +L DL+SE ++K + H ++I L GAC+Q GPL ++VEYA G+LR FLR R Sbjct: 513 DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 572 Query: 822 VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881 G Y S P E LT DL+S A+Q+++GM+YLA K +HRDLAARN+L Sbjct: 573 PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 624 Query: 882 VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941 V E MKI+DFGL+RDV+ D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL Sbjct: 625 VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 684 Query: 942 WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001 WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW P +RP F + Sbjct: 685 WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 744 Query: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033 +DL++++ +YLDL+A TPS S DD + Sbjct: 745 VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 788 >gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor [Homo sapiens] Length = 731 Score = 328 bits (840), Expect = 2e-89 Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%) Query: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693 +F++S ++ + ++ K S +M + A++ P VS SS + Sbjct: 293 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 351 Query: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747 RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K Sbjct: 352 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 411 Query: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805 + T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE Sbjct: 412 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 471 Query: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865 YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL Sbjct: 472 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 523 Query: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925 A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD Sbjct: 524 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 583 Query: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985 IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M Sbjct: 584 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 643 Query: 986 QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019 CW P +RP F + +DL+++ + ++YLDL+ Sbjct: 644 DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 679 >gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor [Homo sapiens] Length = 733 Score = 328 bits (840), Expect = 2e-89 Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%) Query: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693 +F++S ++ + ++ K S +M + A++ P VS SS + Sbjct: 295 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 353 Query: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747 RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K Sbjct: 354 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 413 Query: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805 + T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE Sbjct: 414 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 473 Query: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865 YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL Sbjct: 474 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 525 Query: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925 A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD Sbjct: 526 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 585 Query: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985 IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M Sbjct: 586 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 645 Query: 986 QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019 CW P +RP F + +DL+++ + ++YLDL+ Sbjct: 646 DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 681 >gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor [Homo sapiens] Length = 820 Score = 328 bits (840), Expect = 2e-89 Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%) Query: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693 +F++S ++ + ++ K S +M + A++ P VS SS + Sbjct: 382 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 440 Query: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747 RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K Sbjct: 441 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 500 Query: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805 + T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE Sbjct: 501 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 560 Query: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865 YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL Sbjct: 561 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 612 Query: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925 A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD Sbjct: 613 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 672 Query: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985 IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M Sbjct: 673 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 732 Query: 986 QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019 CW P +RP F + +DL+++ + ++YLDL+ Sbjct: 733 DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 768 >gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor [Homo sapiens] Length = 822 Score = 328 bits (840), Expect = 2e-89 Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%) Query: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693 +F++S ++ + ++ K S +M + A++ P VS SS + Sbjct: 384 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 442 Query: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747 RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K Sbjct: 443 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 502 Query: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805 + T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE Sbjct: 503 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 562 Query: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865 YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL Sbjct: 563 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 614 Query: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925 A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD Sbjct: 615 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 674 Query: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985 IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M Sbjct: 675 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 734 Query: 986 QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019 CW P +RP F + +DL+++ + ++YLDL+ Sbjct: 735 DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 770 >gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor [Homo sapiens] Length = 680 Score = 324 bits (830), Expect = 3e-88 Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%) Query: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729 SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK Sbjct: 346 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 398 Query: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785 LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H Sbjct: 399 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 457 Query: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845 ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E Sbjct: 458 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 509 Query: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905 +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y Sbjct: 510 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 569 Query: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965 K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK Sbjct: 570 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 629 Query: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009 GHRM++P NC+ E+Y +M CW P +RP F + +DL++++ Sbjct: 630 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673 >gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor [Homo sapiens] Length = 769 Score = 324 bits (830), Expect = 3e-88 Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%) Query: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729 SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK Sbjct: 435 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 487 Query: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785 LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H Sbjct: 488 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 546 Query: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845 ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E Sbjct: 547 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 598 Query: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905 +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y Sbjct: 599 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658 Query: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965 K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK Sbjct: 659 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 718 Query: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009 GHRM++P NC+ E+Y +M CW P +RP F + +DL++++ Sbjct: 719 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762 >gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor [Homo sapiens] Length = 707 Score = 324 bits (830), Expect = 3e-88 Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%) Query: 670 SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729 SS+ M P SS+ A P L V +++ EDPKWEFPR L LGK Sbjct: 345 SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 397 Query: 730 LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785 LGEG FG+VV A A + K + TVAVKMLK++A+ +L DL+SE ++K + H Sbjct: 398 LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 456 Query: 786 HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845 ++I L GAC+QDGPL +IVEYA G+LR +LR R G Y S ++ E Sbjct: 457 NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 508 Query: 846 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905 +T DL+S +Q+++GM+YLA K +HRDLAARN+LV E MKI+DFGL+RD+ D Y Sbjct: 509 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 568 Query: 906 VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965 K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK Sbjct: 569 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 628 Query: 966 TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009 GHRM++P NC+ E+Y +M CW P +RP F + +DL++++ Sbjct: 629 EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 672 >gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor [Homo sapiens] Length = 802 Score = 321 bits (823), Expect = 2e-87 Identities = 187/396 (47%), Positives = 248/396 (62%), Gaps = 31/396 (7%) Query: 638 IAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSL 697 +A AVL +++ L +H H +PP + +++ A+ F + SSG SL Sbjct: 378 LALAVLL--LLAGLYRGQALHGRHP---RPPATVQKLSRFPLARQFSLESGSSGKSSSSL 432 Query: 698 DS-----------MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL 746 + VS+D + DP WEFPR LVLGK LGEG FG+VV+A AF + Sbjct: 433 VRGVRLSSSGPALLAGLVSLD---LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGM 489 Query: 747 KGRAG--YTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLI 803 +TVAVKMLK+NAS +L DL+SE V+K + H ++I L G C+Q+GPL +I Sbjct: 490 DPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVI 549 Query: 804 VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQ 863 VE A G+LR FLR R GP L G R+S E L+ L+S A+Q+++GMQ Sbjct: 550 VECAAKGNLREFLRARRPPGPD-LSPDGPRSS-------EGPLSFPVLVSCAYQVARGMQ 601 Query: 864 YLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESL 923 YL K +HRDLAARN+LV E MKI+DFGL+R V+ D Y K S GR+PVKWMA E+L Sbjct: 602 YLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEAL 661 Query: 924 FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL 983 FD +YT QSDVWSFG+LLWEI TLGG+PYPGIP E LF+LL+ GHRM+RP +C E+Y L Sbjct: 662 FDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGL 721 Query: 984 MLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDL 1018 M +CW P +RP F + + L+K+++ +YLDL Sbjct: 722 MRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 757 >gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor [Homo sapiens] Length = 802 Score = 321 bits (823), Expect = 2e-87 Identities = 187/396 (47%), Positives = 248/396 (62%), Gaps = 31/396 (7%) Query: 638 IAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSL 697 +A AVL +++ L +H H +PP + +++ A+ F + SSG SL Sbjct: 378 LALAVLL--LLAGLYRGQALHGRHP---RPPATVQKLSRFPLARQFSLESGSSGKSSSSL 432 Query: 698 DS-----------MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL 746 + VS+D + DP WEFPR LVLGK LGEG FG+VV+A AF + Sbjct: 433 VRGVRLSSSGPALLAGLVSLD---LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGM 489 Query: 747 KGRAG--YTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLI 803 +TVAVKMLK+NAS +L DL+SE V+K + H ++I L G C+Q+GPL +I Sbjct: 490 DPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVI 549 Query: 804 VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQ 863 VE A G+LR FLR R GP L G R+S E L+ L+S A+Q+++GMQ Sbjct: 550 VECAAKGNLREFLRARRPPGPD-LSPDGPRSS-------EGPLSFPVLVSCAYQVARGMQ 601 Query: 864 YLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESL 923 YL K +HRDLAARN+LV E MKI+DFGL+R V+ D Y K S GR+PVKWMA E+L Sbjct: 602 YLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEAL 661 Query: 924 FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL 983 FD +YT QSDVWSFG+LLWEI TLGG+PYPGIP E LF+LL+ GHRM+RP +C E+Y L Sbjct: 662 FDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGL 721 Query: 984 MLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDL 1018 M +CW P +RP F + + L+K+++ +YLDL Sbjct: 722 MRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 757 >gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor [Homo sapiens] Length = 762 Score = 320 bits (820), Expect = 5e-87 Identities = 178/338 (52%), Positives = 228/338 (67%), Gaps = 20/338 (5%) Query: 685 VSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF 744 V SSSG P+L + VS+D + DP WEFPR LVLGK LGEG FG+VV+A AF Sbjct: 396 VRLSSSG---PAL--LAGLVSLD---LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAF 447 Query: 745 HLKGRAG--YTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLL 801 + +TVAVKMLK+NAS +L DL+SE V+K + H ++I L G C+Q+GPL Sbjct: 448 GMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY 507 Query: 802 LIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQG 861 +IVE A G+LR FLR R GP L G R+S E L+ L+S A+Q+++G Sbjct: 508 VIVECAAKGNLREFLRARRPPGPD-LSPDGPRSS-------EGPLSFPVLVSCAYQVARG 559 Query: 862 MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE 921 MQYL K +HRDLAARN+LV E MKI+DFGL+R V+ D Y K S GR+PVKWMA E Sbjct: 560 MQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 619 Query: 922 SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMY 981 +LFD +YT QSDVWSFG+LLWEI TLGG+PYPGIP E LF+LL+ GHRM+RP +C E+Y Sbjct: 620 ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELY 679 Query: 982 RLMLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDL 1018 LM +CW P +RP F + + L+K+++ +YLDL Sbjct: 680 GLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 717 >gi|11321597 kinase insert domain receptor precursor [Homo sapiens] Length = 1356 Score = 274 bits (700), Expect = 4e-73 Identities = 156/375 (41%), Positives = 226/375 (60%), Gaps = 51/375 (13%) Query: 716 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775 KWEFPR L LGK LG G FG+V++A AF + A TVAVKMLKE A+ SE R L+SE Sbjct: 826 KWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSE 885 Query: 776 FNVLKQV-NHPHVIKLYGACSQ-DGPLLLIVEYAKYGSLRGFLRESR------------- 820 +L + +H +V+ L GAC++ GPL++IVE+ K+G+L +LR R Sbjct: 886 LKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARF 945 Query: 821 KVGPGYLGS------------GGSRNSSSLDHPDERA-----------------LTMGDL 851 + G Y+G+ S++S+S +E++ LT+ L Sbjct: 946 RQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHL 1005 Query: 852 ISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG 911 I +++Q+++GM++LA K +HRDLAARNIL++E +KI DFGL+RD+Y++ YV++ Sbjct: 1006 ICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDA 1065 Query: 912 RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP-PERLFNLLKTGHRM 970 R+P+KWMA E++FD +YT QSDVWSFGVLLWEI +LG +PYPG+ E LK G RM Sbjct: 1066 RLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRM 1125 Query: 971 ERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR-----RDYLDLAASTPSD 1025 PD + EMY+ ML CW EP +RP F+++ + L ++ +DY+ L S + Sbjct: 1126 RAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPIS-ETL 1184 Query: 1026 SLIYDDGLSEEETPL 1040 S+ D GLS +P+ Sbjct: 1185 SMEEDSGLSLPTSPV 1199 >gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor [Homo sapiens] Length = 785 Score = 273 bits (699), Expect = 5e-73 Identities = 171/411 (41%), Positives = 234/411 (56%), Gaps = 46/411 (11%) Query: 645 SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693 +F++S ++ + ++ K S +M + A++ P VS SS + Sbjct: 384 AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 442 Query: 694 --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747 RPS S V +++ EDP+WE PR LVLGK LGEG FG+VV A A L K Sbjct: 443 LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 502 Query: 748 GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805 + T VAVKMLK +A+ +L DL+SE ++K + H ++I L GAC+QDGPL +IVE Sbjct: 503 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 562 Query: 806 YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865 YA G+LR +L+ R G Y + H E L+ DL+S A+Q+++GM+YL Sbjct: 563 YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 614 Query: 866 AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925 A K +HRDLAARN+LV E MKI+DFGL+RD++ D Y K + GR+PVKWMA E+LFD Sbjct: 615 ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 674 Query: 926 HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985 IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF L E++ R++ Sbjct: 675 RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKQL------------VEDLDRIVA 722 Query: 986 QCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEE 1036 QE + D+S L++ D S+ DS+ + L EE Sbjct: 723 LTSNQE------YLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEE 767 >gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [Homo sapiens] Length = 1138 Score = 259 bits (663), Expect = 8e-69 Identities = 158/389 (40%), Positives = 225/389 (57%), Gaps = 43/389 (11%) Query: 634 CRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGAR 693 C T++AA + V + C+H F ++ S E T + + S + + R Sbjct: 773 CLTILAA-----LLTLVCIRRSCLHRRRTFTYQS--GSGEETILQFS-----SGTLTLTR 820 Query: 694 RPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYT 753 RP L Q ++ +LE WE ++ +GEG FG+V++A +K Sbjct: 821 RPKL-----QPEPLSYPVLE---WE----DITFEDLIGEGNFGQVIRAM---IKKDGLKM 865 Query: 754 TVAVKMLKENASPSELRDLLSEFNVL-KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL 812 A+KMLKE AS ++ RD E VL K +HP++I L GAC G L + +EYA YG+L Sbjct: 866 NAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNL 925 Query: 813 RGFLRESR--KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL 870 FLR+SR + P + + +H L+ L+ FA + GMQYL+E + Sbjct: 926 LDFLRKSRVLETDPAF----------AREHGTASTLSSRQLLRFASDAANGMQYLSEKQF 975 Query: 871 VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTT 930 +HRDLAARN+LV E KI+DFGLSR E+ YVK++ GR+PV+WMAIESL +YTT Sbjct: 976 IHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTT 1032 Query: 931 QSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ 990 +SDVWSFGVLLWEIV+LGG PY G+ L+ L G+RME+P NC +E+Y LM QCW+ Sbjct: 1033 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD 1092 Query: 991 EPDKRPVFADISKDLEKMMVKRRDYLDLA 1019 P +RP FA I+ L +M+ R+ Y++++ Sbjct: 1093 RPYERPPFAQIALQLGRMLEARKAYVNMS 1121 >gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens] Length = 1124 Score = 244 bits (622), Expect = 4e-64 Identities = 131/291 (45%), Positives = 187/291 (64%), Gaps = 19/291 (6%) Query: 730 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVL-KQVNHPHVI 788 +GEG FG+V+KA +K A+K +KE AS + RD E VL K +HP++I Sbjct: 830 IGEGNFGQVLKA---RIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNII 886 Query: 789 KLYGACSQDGPLLLIVEYAKYGSLRGFLRESR--KVGPGYLGSGGSRNSSSLDHPDERAL 846 L GAC G L L +EYA +G+L FLR+SR + P + + + ++ L Sbjct: 887 NLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAST----------L 936 Query: 847 TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYV 906 + L+ FA +++GM YL++ + +HRDLAARNILV E KI+DFGLSR ++ YV Sbjct: 937 SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG---QEVYV 993 Query: 907 KRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKT 966 K++ GR+PV+WMAIESL +YTT SDVWS+GVLLWEIV+LGG PY G+ L+ L Sbjct: 994 KKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1053 Query: 967 GHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLD 1017 G+R+E+P NC +E+Y LM QCW+++P +RP FA I L +M+ +R+ Y++ Sbjct: 1054 GYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVN 1104 >gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] Length = 2347 Score = 234 bits (596), Expect = 4e-61 Identities = 127/297 (42%), Positives = 176/297 (59%), Gaps = 29/297 (9%) Query: 719 FPRKNLVLGKTLGEGEFGKVVKATAFHLKG-RAGYTTVAVKMLKENASPSELRDLLSEFN 777 FPR+ L L LG G FG+V + TA + G +G VAVK LK+ ++ E + L E + Sbjct: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAH 1999 Query: 778 VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV---GPGYLGSGGSRN 834 ++ + NHP+++K G C + P +I+E + G L +LR++R GP Sbjct: 2000 LMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP---------- 2049 Query: 835 SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-----EGRKMK 889 LT+ DL+ IS+G YL M +HRDLAARN LV+ R +K Sbjct: 2050 ----------LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVK 2099 Query: 890 ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 949 I DFGL+RD+Y+ D Y KR +G +PV+WMA ESL D I+TTQSDVWSFG+L+WEI+TLG Sbjct: 2100 IGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH 2159 Query: 950 NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE 1006 PYP + N ++TG R+E P NC ++++ LM QCW QEPD+RP F I L+ Sbjct: 2160 QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216 >gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] Length = 869 Score = 230 bits (587), Expect = 5e-60 Identities = 132/377 (35%), Positives = 199/377 (52%), Gaps = 19/377 (5%) Query: 638 IAAAVLFSFIVSVLLSAFCIHCYHK---FAHKPPISSAEMTFRRPAQAFPVSYSSSGARR 694 + +++ SF + VLL+ ++C + + +K S+A P++ Sbjct: 496 VIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELL----------- 544 Query: 695 PSLDSMENQVSVDAFKILEDPKW---EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAG 751 LD + +L +PK E+PR N+ + +GEG FG+V +A A L Sbjct: 545 --LDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP 602 Query: 752 YTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS 811 +T VAVKMLKE AS D E ++ + ++P+++KL G C+ P+ L+ EY YG Sbjct: 603 FTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGD 662 Query: 812 LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLV 871 L FLR L + + P L+ + + A Q++ GM YL+E K V Sbjct: 663 LNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFV 722 Query: 872 HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQ 931 HRDLA RN LV E +KI+DFGLSR++Y D Y IP++WM ES+F + YTT+ Sbjct: 723 HRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTE 782 Query: 932 SDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE 991 SDVW++GV+LWEI + G PY G+ E + ++ G+ + P+NC E+Y LM CW + Sbjct: 783 SDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKL 842 Query: 992 PDKRPVFADISKDLEKM 1008 P RP F I + LE+M Sbjct: 843 PADRPSFTSIHRILERM 859 >gi|4557665 insulin-like growth factor 1 receptor precursor [Homo sapiens] Length = 1367 Score = 223 bits (567), Expect = 1e-57 Identities = 117/294 (39%), Positives = 171/294 (58%), Gaps = 14/294 (4%) Query: 716 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775 +WE R+ + + + LG+G FG V + A + T VA+K + E AS E + L+E Sbjct: 991 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 1050 Query: 776 FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835 +V+K+ N HV++L G SQ P L+I+E G L+ +LR R N+ Sbjct: 1051 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE---------MENN 1101 Query: 836 SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895 L P ++ +I A +I+ GM YL K VHRDLAARN +VAE +KI DFG+ Sbjct: 1102 PVLAPP-----SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGM 1156 Query: 896 SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955 +RD+YE D Y K +G +PV+WM+ ESL D ++TT SDVWSFGV+LWEI TL PY G+ Sbjct: 1157 TRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGL 1216 Query: 956 PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009 E++ + G +++PDNC + ++ LM CW+ P RP F +I +++ M Sbjct: 1217 SNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEM 1270 >gi|31657140 insulin receptor-related receptor precursor [Homo sapiens] Length = 1297 Score = 221 bits (563), Expect = 3e-57 Identities = 120/292 (41%), Positives = 169/292 (57%), Gaps = 14/292 (4%) Query: 716 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775 +WE PR+ + + + LG+G FG V + A L+ T VA+K + E ASP E + L E Sbjct: 971 EWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKE 1030 Query: 776 FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835 +V+K HV++L G SQ P L+I+E G L+ LR R + N+ Sbjct: 1031 ASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPE---------AENN 1081 Query: 836 SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895 L P +G++I A +I+ GM YLA K VHRDLAARN +V++ +KI DFG+ Sbjct: 1082 PGLPQP-----ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGM 1136 Query: 896 SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955 +RDVYE D Y K +G +PV+WMA ESL D I+TT SDVWSFGV+LWEIVTL PY G+ Sbjct: 1137 TRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGL 1196 Query: 956 PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK 1007 E++ + G +E + C ++ LM +CW+ P RP F I +++ Sbjct: 1197 SNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQE 1248 >gi|119395738 insulin receptor isoform Short precursor [Homo sapiens] Length = 1370 Score = 220 bits (560), Expect = 7e-57 Identities = 126/341 (36%), Positives = 183/341 (53%), Gaps = 28/341 (8%) Query: 716 KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775 +WE R+ + L + LG+G FG V + A + T VAVK + E+AS E + L+E Sbjct: 1003 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNE 1062 Query: 776 FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835 +V+K HV++L G S+ P L+++E +G L+ +LR R Sbjct: 1063 ASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP-------------- 1108 Query: 836 SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895 + ++P T+ ++I A +I+ GM YL K VHRDLAARN +VA +KI DFG+ Sbjct: 1109 EAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGM 1168 Query: 896 SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955 +RD+YE D Y K +G +PV+WMA ESL D ++TT SD+WSFGV+LWEI +L PY G+ Sbjct: 1169 TRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGL 1228 Query: 956 PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY 1015 E++ + G +++PDNC E + LM CW+ P RP F +I L+ Sbjct: 1229 SNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD-------- 1280 Query: 1016 LDLAASTPSDSLIYDD-----GLSEEETPLVDCNNAPLPRA 1051 DL S P S + + E E D N PL R+ Sbjct: 1281 -DLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRS 1320 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.136 0.420 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 46,515,652 Number of Sequences: 37866 Number of extensions: 2320885 Number of successful extensions: 7637 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 558 Number of HSP's successfully gapped in prelim test: 281 Number of HSP's that attempted gapping in prelim test: 5387 Number of HSP's gapped (non-prelim): 1380 length of query: 1114 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1001 effective length of database: 13,968,660 effective search space: 13982628660 effective search space used: 13982628660 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.