Guide to the Human Genome
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Search of human proteins with 10862701

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
         (1072 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10862701 ret proto-oncogene isoform c [Homo sapiens]              2188   0.0  
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]              2170   0.0  
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   330   4e-90
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   329   7e-90
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   329   7e-90
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   329   7e-90
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   329   7e-90
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   329   7e-90
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   328   2e-89
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   328   2e-89
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   328   2e-89
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   328   2e-89
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   328   2e-89
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   328   2e-89
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   328   2e-89
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   324   3e-88
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   324   3e-88
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   324   3e-88
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   321   2e-87
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   321   2e-87
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   320   5e-87
gi|11321597 kinase insert domain receptor precursor [Homo sapiens]    274   4e-73
gi|13186249 fibroblast growth factor receptor 1 isoform 9 precur...   273   5e-73
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like...   259   7e-69
gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sap...   244   4e-64
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]   234   4e-61
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    230   5e-60
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   223   1e-57
gi|31657140 insulin receptor-related receptor precursor [Homo sa...   221   3e-57
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   220   6e-57

>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score = 2188 bits (5670), Expect = 0.0
 Identities = 1072/1072 (100%), Positives = 1072/1072 (100%)

Query: 1    MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP 60
            MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP
Sbjct: 1    MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP 60

Query: 61   EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT 120
            EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT
Sbjct: 61   EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT 120

Query: 121  VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR 180
            VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
Sbjct: 121  VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR 180

Query: 181  PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV 240
            PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV
Sbjct: 181  PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV 240

Query: 241  AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD 300
            AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD
Sbjct: 241  AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD 300

Query: 301  ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR 360
            ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
Sbjct: 301  ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR 360

Query: 361  NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA 420
            NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA
Sbjct: 361  NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA 420

Query: 421  QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE 480
            QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE
Sbjct: 421  QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE 480

Query: 481  LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR 540
            LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
Sbjct: 481  LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR 540

Query: 541  CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR 600
            CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
Sbjct: 541  CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR 600

Query: 601  GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY 660
            GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY
Sbjct: 601  GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY 660

Query: 661  HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP 720
            HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
Sbjct: 661  HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP 720

Query: 721  RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 780
            RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK
Sbjct: 721  RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 780

Query: 781  QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 840
            QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH
Sbjct: 781  QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 840

Query: 841  PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 900
            PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY
Sbjct: 841  PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 900

Query: 901  EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 960
            EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL
Sbjct: 901  EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 960

Query: 961  FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA 1020
            FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA
Sbjct: 961  FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA 1020

Query: 1021 STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF 1072
            STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF
Sbjct: 1021 STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTRF 1072


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score = 2170 bits (5623), Expect = 0.0
 Identities = 1063/1063 (100%), Positives = 1063/1063 (100%)

Query: 1    MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP 60
            MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP
Sbjct: 1    MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAP 60

Query: 61   EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT 120
            EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT
Sbjct: 61   EEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLT 120

Query: 121  VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR 180
            VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
Sbjct: 121  VYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR 180

Query: 181  PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV 240
            PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV
Sbjct: 181  PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELV 240

Query: 241  AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD 300
            AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD
Sbjct: 241  AVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFD 300

Query: 301  ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR 360
            ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
Sbjct: 301  ADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR 360

Query: 361  NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA 420
            NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA
Sbjct: 361  NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFA 420

Query: 421  QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE 480
            QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE
Sbjct: 421  QIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAE 480

Query: 481  LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR 540
            LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
Sbjct: 481  LHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR 540

Query: 541  CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR 600
            CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
Sbjct: 541  CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR 600

Query: 601  GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY 660
            GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY
Sbjct: 601  GIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCY 660

Query: 661  HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP 720
            HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
Sbjct: 661  HKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP 720

Query: 721  RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 780
            RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK
Sbjct: 721  RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLK 780

Query: 781  QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 840
            QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH
Sbjct: 781  QVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDH 840

Query: 841  PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 900
            PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY
Sbjct: 841  PDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVY 900

Query: 901  EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 960
            EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL
Sbjct: 901  EEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERL 960

Query: 961  FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA 1020
            FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA
Sbjct: 961  FNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAA 1020

Query: 1021 STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYG 1063
            STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYG
Sbjct: 1021 STPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYG 1063


>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
            [Homo sapiens]
          Length = 704

 Score =  330 bits (846), Expect = 4e-90
 Identities = 180/384 (46%), Positives = 238/384 (61%), Gaps = 29/384 (7%)

Query: 661  HKFAHKPPI-------SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILE 713
            HK   + P+       SS+ M    P        SS+ A  P L        V  +++ E
Sbjct: 301  HKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPE 353

Query: 714  DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELR 770
            DPKWEFPR  L LGK LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L 
Sbjct: 354  DPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLS 412

Query: 771  DLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGS 829
            DL+SE  ++K +  H ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y   
Sbjct: 413  DLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--- 469

Query: 830  GGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMK 889
                 S  ++   E  +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MK
Sbjct: 470  -----SYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMK 524

Query: 890  ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 949
            I+DFGL+RD+   D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG
Sbjct: 525  IADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGG 584

Query: 950  NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM- 1008
            +PYPGIP E LF LLK GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL+++ 
Sbjct: 585  SPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 644

Query: 1009 -MVKRRDYLDLAASTPSDSLIYDD 1031
             +    +YLDL+      S  Y D
Sbjct: 645  TLTTNEEYLDLSQPLEQYSPSYPD 668


>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
            [Homo sapiens]
          Length = 705

 Score =  329 bits (844), Expect = 7e-90
 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)

Query: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 318  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 370

Query: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 371  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 429

Query: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 430  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 481

Query: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 482  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 541

Query: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 542  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 601

Query: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL+++  +    +YLDL+    
Sbjct: 602  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 661

Query: 1024 SDSLIYDD 1031
              S  Y D
Sbjct: 662  QYSPSYPD 669


>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
            [Homo sapiens]
          Length = 706

 Score =  329 bits (844), Expect = 7e-90
 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)

Query: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 319  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 371

Query: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 372  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 430

Query: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 431  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 482

Query: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 483  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 542

Query: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 543  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 602

Query: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL+++  +    +YLDL+    
Sbjct: 603  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 662

Query: 1024 SDSLIYDD 1031
              S  Y D
Sbjct: 663  QYSPSYPD 670


>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
            [Homo sapiens]
          Length = 709

 Score =  329 bits (844), Expect = 7e-90
 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)

Query: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 322  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 374

Query: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 375  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 433

Query: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 434  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 485

Query: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 486  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 545

Query: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 546  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 605

Query: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL+++  +    +YLDL+    
Sbjct: 606  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 665

Query: 1024 SDSLIYDD 1031
              S  Y D
Sbjct: 666  QYSPSYPD 673


>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
            [Homo sapiens]
          Length = 821

 Score =  329 bits (844), Expect = 7e-90
 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)

Query: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 434  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 486

Query: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 487  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 545

Query: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 546  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 597

Query: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 598  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 657

Query: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 658  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 717

Query: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL+++  +    +YLDL+    
Sbjct: 718  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 777

Query: 1024 SDSLIYDD 1031
              S  Y D
Sbjct: 778  QYSPSYPD 785


>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
            [Homo sapiens]
          Length = 822

 Score =  329 bits (844), Expect = 7e-90
 Identities = 177/368 (48%), Positives = 233/368 (63%), Gaps = 22/368 (5%)

Query: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 435  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 487

Query: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 488  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 546

Query: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 547  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 598

Query: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 599  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658

Query: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 659  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 718

Query: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLAASTP 1023
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL+++  +    +YLDL+    
Sbjct: 719  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLE 778

Query: 1024 SDSLIYDD 1031
              S  Y D
Sbjct: 779  QYSPSYPD 786


>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
            [Homo sapiens]
          Length = 808

 Score =  328 bits (840), Expect = 2e-89
 Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%)

Query: 705  SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762
            +V   ++  DPKWE  R  L LGK LGEG FG+VV A A  + K RA    TVAVKMLK+
Sbjct: 455  NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 514

Query: 763  NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821
            +A+  +L DL+SE  ++K +  H ++I L GAC+Q GPL ++VEYA  G+LR FLR  R 
Sbjct: 515  DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 574

Query: 822  VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881
             G  Y        S     P E  LT  DL+S A+Q+++GM+YLA  K +HRDLAARN+L
Sbjct: 575  PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 626

Query: 882  VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941
            V E   MKI+DFGL+RDV+  D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL
Sbjct: 627  VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 686

Query: 942  WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001
            WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW   P +RP F  +
Sbjct: 687  WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 746

Query: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033
             +DL++++      +YLDL+A           TPS S   DD +
Sbjct: 747  VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 790


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
            [Homo sapiens]
          Length = 694

 Score =  328 bits (840), Expect = 2e-89
 Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%)

Query: 705  SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762
            +V   ++  DPKWE  R  L LGK LGEG FG+VV A A  + K RA    TVAVKMLK+
Sbjct: 341  NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 400

Query: 763  NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821
            +A+  +L DL+SE  ++K +  H ++I L GAC+Q GPL ++VEYA  G+LR FLR  R 
Sbjct: 401  DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 460

Query: 822  VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881
             G  Y        S     P E  LT  DL+S A+Q+++GM+YLA  K +HRDLAARN+L
Sbjct: 461  PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 512

Query: 882  VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941
            V E   MKI+DFGL+RDV+  D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL
Sbjct: 513  VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 572

Query: 942  WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001
            WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW   P +RP F  +
Sbjct: 573  WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 632

Query: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033
             +DL++++      +YLDL+A           TPS S   DD +
Sbjct: 633  VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 676


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
            [Homo sapiens]
          Length = 806

 Score =  328 bits (840), Expect = 2e-89
 Identities = 174/344 (50%), Positives = 226/344 (65%), Gaps = 23/344 (6%)

Query: 705  SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-KGRAGY-TTVAVKMLKE 762
            +V   ++  DPKWE  R  L LGK LGEG FG+VV A A  + K RA    TVAVKMLK+
Sbjct: 453  NVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 512

Query: 763  NASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK 821
            +A+  +L DL+SE  ++K +  H ++I L GAC+Q GPL ++VEYA  G+LR FLR  R 
Sbjct: 513  DATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRP 572

Query: 822  VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNIL 881
             G  Y        S     P E  LT  DL+S A+Q+++GM+YLA  K +HRDLAARN+L
Sbjct: 573  PGLDY--------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVL 624

Query: 882  VAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL 941
            V E   MKI+DFGL+RDV+  D Y K + GR+PVKWMA E+LFD +YT QSDVWSFGVLL
Sbjct: 625  VTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLL 684

Query: 942  WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI 1001
            WEI TLGG+PYPGIP E LF LLK GHRM++P NC+ ++Y +M +CW   P +RP F  +
Sbjct: 685  WEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 744

Query: 1002 SKDLEKMM--VKRRDYLDLAA----------STPSDSLIYDDGL 1033
             +DL++++      +YLDL+A           TPS S   DD +
Sbjct: 745  VEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSV 788


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
            [Homo sapiens]
          Length = 731

 Score =  328 bits (840), Expect = 2e-89
 Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%)

Query: 645  SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
            +F++S ++ +  ++       K    S +M   + A++ P      VS  SS +      
Sbjct: 293  AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 351

Query: 694  --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
              RPS  S         V  +++ EDP+WE PR  LVLGK LGEG FG+VV A A  L K
Sbjct: 352  LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 411

Query: 748  GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
             +    T VAVKMLK +A+  +L DL+SE  ++K +  H ++I L GAC+QDGPL +IVE
Sbjct: 412  DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 471

Query: 806  YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
            YA  G+LR +L+  R  G  Y  +          H  E  L+  DL+S A+Q+++GM+YL
Sbjct: 472  YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 523

Query: 866  AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
            A  K +HRDLAARN+LV E   MKI+DFGL+RD++  D Y K + GR+PVKWMA E+LFD
Sbjct: 524  ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 583

Query: 926  HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
             IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M 
Sbjct: 584  RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 643

Query: 986  QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019
             CW   P +RP F  + +DL+++  +   ++YLDL+
Sbjct: 644  DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 679


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
            [Homo sapiens]
          Length = 733

 Score =  328 bits (840), Expect = 2e-89
 Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%)

Query: 645  SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
            +F++S ++ +  ++       K    S +M   + A++ P      VS  SS +      
Sbjct: 295  AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 353

Query: 694  --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
              RPS  S         V  +++ EDP+WE PR  LVLGK LGEG FG+VV A A  L K
Sbjct: 354  LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 413

Query: 748  GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
             +    T VAVKMLK +A+  +L DL+SE  ++K +  H ++I L GAC+QDGPL +IVE
Sbjct: 414  DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 473

Query: 806  YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
            YA  G+LR +L+  R  G  Y  +          H  E  L+  DL+S A+Q+++GM+YL
Sbjct: 474  YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 525

Query: 866  AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
            A  K +HRDLAARN+LV E   MKI+DFGL+RD++  D Y K + GR+PVKWMA E+LFD
Sbjct: 526  ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 585

Query: 926  HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
             IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M 
Sbjct: 586  RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 645

Query: 986  QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019
             CW   P +RP F  + +DL+++  +   ++YLDL+
Sbjct: 646  DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 681


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
            [Homo sapiens]
          Length = 820

 Score =  328 bits (840), Expect = 2e-89
 Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%)

Query: 645  SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
            +F++S ++ +  ++       K    S +M   + A++ P      VS  SS +      
Sbjct: 382  AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 440

Query: 694  --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
              RPS  S         V  +++ EDP+WE PR  LVLGK LGEG FG+VV A A  L K
Sbjct: 441  LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 500

Query: 748  GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
             +    T VAVKMLK +A+  +L DL+SE  ++K +  H ++I L GAC+QDGPL +IVE
Sbjct: 501  DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 560

Query: 806  YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
            YA  G+LR +L+  R  G  Y  +          H  E  L+  DL+S A+Q+++GM+YL
Sbjct: 561  YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 612

Query: 866  AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
            A  K +HRDLAARN+LV E   MKI+DFGL+RD++  D Y K + GR+PVKWMA E+LFD
Sbjct: 613  ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 672

Query: 926  HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
             IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M 
Sbjct: 673  RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 732

Query: 986  QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019
             CW   P +RP F  + +DL+++  +   ++YLDL+
Sbjct: 733  DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 768


>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
            [Homo sapiens]
          Length = 822

 Score =  328 bits (840), Expect = 2e-89
 Identities = 181/396 (45%), Positives = 248/396 (62%), Gaps = 30/396 (7%)

Query: 645  SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
            +F++S ++ +  ++       K    S +M   + A++ P      VS  SS +      
Sbjct: 384  AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 442

Query: 694  --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
              RPS  S         V  +++ EDP+WE PR  LVLGK LGEG FG+VV A A  L K
Sbjct: 443  LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 502

Query: 748  GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
             +    T VAVKMLK +A+  +L DL+SE  ++K +  H ++I L GAC+QDGPL +IVE
Sbjct: 503  DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 562

Query: 806  YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
            YA  G+LR +L+  R  G  Y  +          H  E  L+  DL+S A+Q+++GM+YL
Sbjct: 563  YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 614

Query: 866  AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
            A  K +HRDLAARN+LV E   MKI+DFGL+RD++  D Y K + GR+PVKWMA E+LFD
Sbjct: 615  ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 674

Query: 926  HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
             IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF LLK GHRM++P NC+ E+Y +M 
Sbjct: 675  RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMR 734

Query: 986  QCWKQEPDKRPVFADISKDLEKM--MVKRRDYLDLA 1019
             CW   P +RP F  + +DL+++  +   ++YLDL+
Sbjct: 735  DCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLS 770


>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
            [Homo sapiens]
          Length = 680

 Score =  324 bits (830), Expect = 3e-88
 Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%)

Query: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 346  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 398

Query: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 399  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 457

Query: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 458  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 509

Query: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 510  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 569

Query: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 570  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 629

Query: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL++++
Sbjct: 630  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 673


>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
            [Homo sapiens]
          Length = 769

 Score =  324 bits (830), Expect = 3e-88
 Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%)

Query: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 435  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 487

Query: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 488  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 546

Query: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 547  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 598

Query: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 599  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 658

Query: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 659  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 718

Query: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL++++
Sbjct: 719  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 762


>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
            [Homo sapiens]
          Length = 707

 Score =  324 bits (830), Expect = 3e-88
 Identities = 170/344 (49%), Positives = 224/344 (65%), Gaps = 20/344 (5%)

Query: 670  SSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKT 729
            SS+ M    P        SS+ A  P L        V  +++ EDPKWEFPR  L LGK 
Sbjct: 345  SSSSMNSNTPLVRITTRLSST-ADTPML------AGVSEYELPEDPKWEFPRDKLTLGKP 397

Query: 730  LGEGEFGKVVKATAFHL---KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HP 785
            LGEG FG+VV A A  +   K +    TVAVKMLK++A+  +L DL+SE  ++K +  H 
Sbjct: 398  LGEGCFGQVVMAEAVGIDKDKPKEA-VTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHK 456

Query: 786  HVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERA 845
            ++I L GAC+QDGPL +IVEYA  G+LR +LR  R  G  Y        S  ++   E  
Sbjct: 457  NIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEY--------SYDINRVPEEQ 508

Query: 846  LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY 905
            +T  DL+S  +Q+++GM+YLA  K +HRDLAARN+LV E   MKI+DFGL+RD+   D Y
Sbjct: 509  MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 568

Query: 906  VKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLK 965
             K + GR+PVKWMA E+LFD +YT QSDVWSFGVL+WEI TLGG+PYPGIP E LF LLK
Sbjct: 569  KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 628

Query: 966  TGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
             GHRM++P NC+ E+Y +M  CW   P +RP F  + +DL++++
Sbjct: 629  EGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 672


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
            [Homo sapiens]
          Length = 802

 Score =  321 bits (823), Expect = 2e-87
 Identities = 187/396 (47%), Positives = 248/396 (62%), Gaps = 31/396 (7%)

Query: 638  IAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSL 697
            +A AVL   +++ L     +H  H    +PP +  +++    A+ F +   SSG    SL
Sbjct: 378  LALAVLL--LLAGLYRGQALHGRHP---RPPATVQKLSRFPLARQFSLESGSSGKSSSSL 432

Query: 698  DS-----------MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL 746
                         +   VS+D   +  DP WEFPR  LVLGK LGEG FG+VV+A AF +
Sbjct: 433  VRGVRLSSSGPALLAGLVSLD---LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGM 489

Query: 747  KGRAG--YTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLI 803
                    +TVAVKMLK+NAS  +L DL+SE  V+K +  H ++I L G C+Q+GPL +I
Sbjct: 490  DPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVI 549

Query: 804  VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQ 863
            VE A  G+LR FLR  R  GP  L   G R+S       E  L+   L+S A+Q+++GMQ
Sbjct: 550  VECAAKGNLREFLRARRPPGPD-LSPDGPRSS-------EGPLSFPVLVSCAYQVARGMQ 601

Query: 864  YLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESL 923
            YL   K +HRDLAARN+LV E   MKI+DFGL+R V+  D Y K S GR+PVKWMA E+L
Sbjct: 602  YLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEAL 661

Query: 924  FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL 983
            FD +YT QSDVWSFG+LLWEI TLGG+PYPGIP E LF+LL+ GHRM+RP +C  E+Y L
Sbjct: 662  FDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGL 721

Query: 984  MLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDL 1018
            M +CW   P +RP F  + + L+K+++    +YLDL
Sbjct: 722  MRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 757


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
            [Homo sapiens]
          Length = 802

 Score =  321 bits (823), Expect = 2e-87
 Identities = 187/396 (47%), Positives = 248/396 (62%), Gaps = 31/396 (7%)

Query: 638  IAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSL 697
            +A AVL   +++ L     +H  H    +PP +  +++    A+ F +   SSG    SL
Sbjct: 378  LALAVLL--LLAGLYRGQALHGRHP---RPPATVQKLSRFPLARQFSLESGSSGKSSSSL 432

Query: 698  DS-----------MENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL 746
                         +   VS+D   +  DP WEFPR  LVLGK LGEG FG+VV+A AF +
Sbjct: 433  VRGVRLSSSGPALLAGLVSLD---LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGM 489

Query: 747  KGRAG--YTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLI 803
                    +TVAVKMLK+NAS  +L DL+SE  V+K +  H ++I L G C+Q+GPL +I
Sbjct: 490  DPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVI 549

Query: 804  VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQ 863
            VE A  G+LR FLR  R  GP  L   G R+S       E  L+   L+S A+Q+++GMQ
Sbjct: 550  VECAAKGNLREFLRARRPPGPD-LSPDGPRSS-------EGPLSFPVLVSCAYQVARGMQ 601

Query: 864  YLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESL 923
            YL   K +HRDLAARN+LV E   MKI+DFGL+R V+  D Y K S GR+PVKWMA E+L
Sbjct: 602  YLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEAL 661

Query: 924  FDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRL 983
            FD +YT QSDVWSFG+LLWEI TLGG+PYPGIP E LF+LL+ GHRM+RP +C  E+Y L
Sbjct: 662  FDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGL 721

Query: 984  MLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDL 1018
            M +CW   P +RP F  + + L+K+++    +YLDL
Sbjct: 722  MRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 757


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
            [Homo sapiens]
          Length = 762

 Score =  320 bits (820), Expect = 5e-87
 Identities = 178/338 (52%), Positives = 228/338 (67%), Gaps = 20/338 (5%)

Query: 685  VSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAF 744
            V  SSSG   P+L  +   VS+D   +  DP WEFPR  LVLGK LGEG FG+VV+A AF
Sbjct: 396  VRLSSSG---PAL--LAGLVSLD---LPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAF 447

Query: 745  HLKGRAG--YTTVAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLL 801
             +        +TVAVKMLK+NAS  +L DL+SE  V+K +  H ++I L G C+Q+GPL 
Sbjct: 448  GMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLY 507

Query: 802  LIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQG 861
            +IVE A  G+LR FLR  R  GP  L   G R+S       E  L+   L+S A+Q+++G
Sbjct: 508  VIVECAAKGNLREFLRARRPPGPD-LSPDGPRSS-------EGPLSFPVLVSCAYQVARG 559

Query: 862  MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE 921
            MQYL   K +HRDLAARN+LV E   MKI+DFGL+R V+  D Y K S GR+PVKWMA E
Sbjct: 560  MQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPE 619

Query: 922  SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMY 981
            +LFD +YT QSDVWSFG+LLWEI TLGG+PYPGIP E LF+LL+ GHRM+RP +C  E+Y
Sbjct: 620  ALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELY 679

Query: 982  RLMLQCWKQEPDKRPVFADISKDLEKMMVK-RRDYLDL 1018
             LM +CW   P +RP F  + + L+K+++    +YLDL
Sbjct: 680  GLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDL 717


>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
          Length = 1356

 Score =  274 bits (700), Expect = 4e-73
 Identities = 156/375 (41%), Positives = 226/375 (60%), Gaps = 51/375 (13%)

Query: 716  KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775
            KWEFPR  L LGK LG G FG+V++A AF +   A   TVAVKMLKE A+ SE R L+SE
Sbjct: 826  KWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSE 885

Query: 776  FNVLKQV-NHPHVIKLYGACSQ-DGPLLLIVEYAKYGSLRGFLRESR------------- 820
              +L  + +H +V+ L GAC++  GPL++IVE+ K+G+L  +LR  R             
Sbjct: 886  LKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARF 945

Query: 821  KVGPGYLGS------------GGSRNSSSLDHPDERA-----------------LTMGDL 851
            + G  Y+G+              S++S+S    +E++                 LT+  L
Sbjct: 946  RQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHL 1005

Query: 852  ISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG 911
            I +++Q+++GM++LA  K +HRDLAARNIL++E   +KI DFGL+RD+Y++  YV++   
Sbjct: 1006 ICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDA 1065

Query: 912  RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP-PERLFNLLKTGHRM 970
            R+P+KWMA E++FD +YT QSDVWSFGVLLWEI +LG +PYPG+   E     LK G RM
Sbjct: 1066 RLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRM 1125

Query: 971  ERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKR-----RDYLDLAASTPSD 1025
              PD  + EMY+ ML CW  EP +RP F+++ + L  ++        +DY+ L  S  + 
Sbjct: 1126 RAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPIS-ETL 1184

Query: 1026 SLIYDDGLSEEETPL 1040
            S+  D GLS   +P+
Sbjct: 1185 SMEEDSGLSLPTSPV 1199


>gi|13186249 fibroblast growth factor receptor 1 isoform 9 precursor
            [Homo sapiens]
          Length = 785

 Score =  273 bits (699), Expect = 5e-73
 Identities = 171/411 (41%), Positives = 234/411 (56%), Gaps = 46/411 (11%)

Query: 645  SFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFP------VSYSSSGAR----- 693
            +F++S ++ +  ++       K    S +M   + A++ P      VS  SS +      
Sbjct: 384  AFLISCMVGSVIVYKMKSGTKKSDFHS-QMAVHKLAKSIPLRRQVTVSADSSASMNSGVL 442

Query: 694  --RPSLDSMENQ---VSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL-K 747
              RPS  S         V  +++ EDP+WE PR  LVLGK LGEG FG+VV A A  L K
Sbjct: 443  LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 502

Query: 748  GRAGYTT-VAVKMLKENASPSELRDLLSEFNVLKQVN-HPHVIKLYGACSQDGPLLLIVE 805
             +    T VAVKMLK +A+  +L DL+SE  ++K +  H ++I L GAC+QDGPL +IVE
Sbjct: 503  DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVE 562

Query: 806  YAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYL 865
            YA  G+LR +L+  R  G  Y  +          H  E  L+  DL+S A+Q+++GM+YL
Sbjct: 563  YASKGNLREYLQARRPPGLEYCYNPS--------HNPEEQLSSKDLVSCAYQVARGMEYL 614

Query: 866  AEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFD 925
            A  K +HRDLAARN+LV E   MKI+DFGL+RD++  D Y K + GR+PVKWMA E+LFD
Sbjct: 615  ASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFD 674

Query: 926  HIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLML 985
             IYT QSDVWSFGVLLWEI TLGG+PYPG+P E LF  L             E++ R++ 
Sbjct: 675  RIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKQL------------VEDLDRIVA 722

Query: 986  QCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEE 1036
                QE      + D+S  L++      D      S+  DS+   + L EE
Sbjct: 723  LTSNQE------YLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEE 767


>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
            domains 1 [Homo sapiens]
          Length = 1138

 Score =  259 bits (663), Expect = 7e-69
 Identities = 158/389 (40%), Positives = 225/389 (57%), Gaps = 43/389 (11%)

Query: 634  CRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGAR 693
            C T++AA      +  V +   C+H    F ++    S E T  + +     S + +  R
Sbjct: 773  CLTILAA-----LLTLVCIRRSCLHRRRTFTYQS--GSGEETILQFS-----SGTLTLTR 820

Query: 694  RPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYT 753
            RP L     Q    ++ +LE   WE    ++     +GEG FG+V++A    +K      
Sbjct: 821  RPKL-----QPEPLSYPVLE---WE----DITFEDLIGEGNFGQVIRAM---IKKDGLKM 865

Query: 754  TVAVKMLKENASPSELRDLLSEFNVL-KQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSL 812
              A+KMLKE AS ++ RD   E  VL K  +HP++I L GAC   G L + +EYA YG+L
Sbjct: 866  NAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNL 925

Query: 813  RGFLRESR--KVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKL 870
              FLR+SR  +  P +          + +H     L+   L+ FA   + GMQYL+E + 
Sbjct: 926  LDFLRKSRVLETDPAF----------AREHGTASTLSSRQLLRFASDAANGMQYLSEKQF 975

Query: 871  VHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTT 930
            +HRDLAARN+LV E    KI+DFGLSR    E+ YVK++ GR+PV+WMAIESL   +YTT
Sbjct: 976  IHRDLAARNVLVGENLASKIADFGLSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTT 1032

Query: 931  QSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQ 990
            +SDVWSFGVLLWEIV+LGG PY G+    L+  L  G+RME+P NC +E+Y LM QCW+ 
Sbjct: 1033 KSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRD 1092

Query: 991  EPDKRPVFADISKDLEKMMVKRRDYLDLA 1019
             P +RP FA I+  L +M+  R+ Y++++
Sbjct: 1093 RPYERPPFAQIALQLGRMLEARKAYVNMS 1121


>gi|88758596 TEK tyrosine kinase, endothelial precursor [Homo sapiens]
          Length = 1124

 Score =  244 bits (622), Expect = 4e-64
 Identities = 131/291 (45%), Positives = 187/291 (64%), Gaps = 19/291 (6%)

Query: 730  LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVL-KQVNHPHVI 788
            +GEG FG+V+KA    +K        A+K +KE AS  + RD   E  VL K  +HP++I
Sbjct: 830  IGEGNFGQVLKA---RIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNII 886

Query: 789  KLYGACSQDGPLLLIVEYAKYGSLRGFLRESR--KVGPGYLGSGGSRNSSSLDHPDERAL 846
             L GAC   G L L +EYA +G+L  FLR+SR  +  P +  +  + ++          L
Sbjct: 887  NLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTAST----------L 936

Query: 847  TMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYV 906
            +   L+ FA  +++GM YL++ + +HRDLAARNILV E    KI+DFGLSR    ++ YV
Sbjct: 937  SSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRG---QEVYV 993

Query: 907  KRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKT 966
            K++ GR+PV+WMAIESL   +YTT SDVWS+GVLLWEIV+LGG PY G+    L+  L  
Sbjct: 994  KKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQ 1053

Query: 967  GHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLD 1017
            G+R+E+P NC +E+Y LM QCW+++P +RP FA I   L +M+ +R+ Y++
Sbjct: 1054 GYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVN 1104


>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
          Length = 2347

 Score =  234 bits (596), Expect = 4e-61
 Identities = 127/297 (42%), Positives = 176/297 (59%), Gaps = 29/297 (9%)

Query: 719  FPRKNLVLGKTLGEGEFGKVVKATAFHLKG-RAGYTTVAVKMLKENASPSELRDLLSEFN 777
            FPR+ L L   LG G FG+V + TA  + G  +G   VAVK LK+ ++  E  + L E +
Sbjct: 1940 FPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAH 1999

Query: 778  VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV---GPGYLGSGGSRN 834
            ++ + NHP+++K  G C  + P  +I+E  + G L  +LR++R     GP          
Sbjct: 2000 LMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP---------- 2049

Query: 835  SSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-----EGRKMK 889
                       LT+ DL+     IS+G  YL  M  +HRDLAARN LV+       R +K
Sbjct: 2050 ----------LLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVK 2099

Query: 890  ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGG 949
            I DFGL+RD+Y+ D Y KR +G +PV+WMA ESL D I+TTQSDVWSFG+L+WEI+TLG 
Sbjct: 2100 IGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH 2159

Query: 950  NPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE 1006
             PYP      + N ++TG R+E P NC ++++ LM QCW QEPD+RP F  I   L+
Sbjct: 2160 QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 2216


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  230 bits (587), Expect = 5e-60
 Identities = 132/377 (35%), Positives = 199/377 (52%), Gaps = 19/377 (5%)

Query: 638  IAAAVLFSFIVSVLLSAFCIHCYHK---FAHKPPISSAEMTFRRPAQAFPVSYSSSGARR 694
            +  +++ SF + VLL+   ++C  +   + +K   S+A      P++             
Sbjct: 496  VIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELL----------- 544

Query: 695  PSLDSMENQVSVDAFKILEDPKW---EFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAG 751
              LD +          +L +PK    E+PR N+   + +GEG FG+V +A A  L     
Sbjct: 545  --LDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEP 602

Query: 752  YTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS 811
            +T VAVKMLKE AS     D   E  ++ + ++P+++KL G C+   P+ L+ EY  YG 
Sbjct: 603  FTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGD 662

Query: 812  LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLV 871
            L  FLR         L        + +  P    L+  + +  A Q++ GM YL+E K V
Sbjct: 663  LNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFV 722

Query: 872  HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQ 931
            HRDLA RN LV E   +KI+DFGLSR++Y  D Y       IP++WM  ES+F + YTT+
Sbjct: 723  HRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTE 782

Query: 932  SDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQE 991
            SDVW++GV+LWEI + G  PY G+  E +   ++ G+ +  P+NC  E+Y LM  CW + 
Sbjct: 783  SDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKL 842

Query: 992  PDKRPVFADISKDLEKM 1008
            P  RP F  I + LE+M
Sbjct: 843  PADRPSFTSIHRILERM 859


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  223 bits (567), Expect = 1e-57
 Identities = 117/294 (39%), Positives = 171/294 (58%), Gaps = 14/294 (4%)

Query: 716  KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775
            +WE  R+ + + + LG+G FG V +  A  +      T VA+K + E AS  E  + L+E
Sbjct: 991  EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 1050

Query: 776  FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835
             +V+K+ N  HV++L G  SQ  P L+I+E    G L+ +LR  R             N+
Sbjct: 1051 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE---------MENN 1101

Query: 836  SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895
              L  P     ++  +I  A +I+ GM YL   K VHRDLAARN +VAE   +KI DFG+
Sbjct: 1102 PVLAPP-----SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGM 1156

Query: 896  SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955
            +RD+YE D Y K  +G +PV+WM+ ESL D ++TT SDVWSFGV+LWEI TL   PY G+
Sbjct: 1157 TRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGL 1216

Query: 956  PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009
              E++   +  G  +++PDNC + ++ LM  CW+  P  RP F +I   +++ M
Sbjct: 1217 SNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEM 1270


>gi|31657140 insulin receptor-related receptor precursor [Homo
            sapiens]
          Length = 1297

 Score =  221 bits (563), Expect = 3e-57
 Identities = 120/292 (41%), Positives = 169/292 (57%), Gaps = 14/292 (4%)

Query: 716  KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775
            +WE PR+ + + + LG+G FG V +  A  L+     T VA+K + E ASP E  + L E
Sbjct: 971  EWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKE 1030

Query: 776  FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835
             +V+K     HV++L G  SQ  P L+I+E    G L+  LR  R           + N+
Sbjct: 1031 ASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPE---------AENN 1081

Query: 836  SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895
              L  P      +G++I  A +I+ GM YLA  K VHRDLAARN +V++   +KI DFG+
Sbjct: 1082 PGLPQP-----ALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGM 1136

Query: 896  SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955
            +RDVYE D Y K  +G +PV+WMA ESL D I+TT SDVWSFGV+LWEIVTL   PY G+
Sbjct: 1137 TRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGL 1196

Query: 956  PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK 1007
              E++   +  G  +E  + C  ++  LM +CW+  P  RP F  I   +++
Sbjct: 1197 SNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQE 1248


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  220 bits (560), Expect = 6e-57
 Identities = 126/341 (36%), Positives = 183/341 (53%), Gaps = 28/341 (8%)

Query: 716  KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSE 775
            +WE  R+ + L + LG+G FG V +  A  +      T VAVK + E+AS  E  + L+E
Sbjct: 1003 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNE 1062

Query: 776  FNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNS 835
             +V+K     HV++L G  S+  P L+++E   +G L+ +LR  R               
Sbjct: 1063 ASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRP-------------- 1108

Query: 836  SSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGL 895
             + ++P     T+ ++I  A +I+ GM YL   K VHRDLAARN +VA    +KI DFG+
Sbjct: 1109 EAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGM 1168

Query: 896  SRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI 955
            +RD+YE D Y K  +G +PV+WMA ESL D ++TT SD+WSFGV+LWEI +L   PY G+
Sbjct: 1169 TRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGL 1228

Query: 956  PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDY 1015
              E++   +  G  +++PDNC E +  LM  CW+  P  RP F +I   L+         
Sbjct: 1229 SNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKD-------- 1280

Query: 1016 LDLAASTPSDSLIYDD-----GLSEEETPLVDCNNAPLPRA 1051
             DL  S P  S  + +        E E    D  N PL R+
Sbjct: 1281 -DLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRS 1320


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,171,926
Number of Sequences: 37866
Number of extensions: 2163284
Number of successful extensions: 7290
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 558
Number of HSP's successfully gapped in prelim test: 277
Number of HSP's that attempted gapping in prelim test: 5050
Number of HSP's gapped (non-prelim): 1363
length of query: 1072
length of database: 18,247,518
effective HSP length: 113
effective length of query: 959
effective length of database: 13,968,660
effective search space: 13395944940
effective search space used: 13395944940
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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