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Search of human proteins with 10835175
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
(471 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo sa... 935 0.0
gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo sap... 425 e-119
gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo s... 358 6e-99
gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo sap... 186 4e-47
gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens] 177 2e-44
gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens] 177 2e-44
gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens] 177 2e-44
gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo sap... 174 2e-43
gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens] 174 2e-43
gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo sapi... 172 6e-43
gi|89191863 dopamine receptor D3 isoform e [Homo sapiens] 172 8e-43
gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo sa... 171 1e-42
gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo sap... 171 1e-42
gi|4557265 beta-1-adrenergic receptor [Homo sapiens] 166 4e-41
gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens] 158 1e-38
gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens] 158 1e-38
gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens] 158 1e-38
gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens] 158 1e-38
gi|4503383 dopamine receptor D1 [Homo sapiens] 157 2e-38
gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens] 155 7e-38
gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens] 155 7e-38
gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens] 154 2e-37
gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens] 150 3e-36
gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens] 149 4e-36
gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens] 149 4e-36
gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens] 148 9e-36
gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens] 148 9e-36
gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens] 148 9e-36
gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens] 148 9e-36
gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens] 148 9e-36
>gi|10835175 5-hydroxytryptamine (serotonin) receptor 2A [Homo
sapiens]
Length = 471
Score = 935 bits (2416), Expect = 0.0
Identities = 471/471 (100%), Positives = 471/471 (100%)
Query: 1 MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC 60
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC
Sbjct: 1 MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGC 60
Query: 61 LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD 120
LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
Sbjct: 61 LSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD 120
Query: 121 MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP 180
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
Sbjct: 121 MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP 180
Query: 181 IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF 240
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
Sbjct: 181 IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF 240
Query: 241 VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH 300
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH
Sbjct: 241 VSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH 300
Query: 301 REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA 360
REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA
Sbjct: 301 REPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGA 360
Query: 361 LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK 420
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK
Sbjct: 361 LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYK 420
Query: 421 SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV 471
SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
Sbjct: 421 SSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV 471
>gi|4504541 5-hydroxytryptamine (serotonin) receptor 2C [Homo
sapiens]
Length = 458
Score = 425 bits (1092), Expect = e-119
Identities = 226/408 (55%), Positives = 289/408 (70%), Gaps = 12/408 (2%)
Query: 74 KNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSML 133
+NW AL ++II+TI GNILVIMAVS+EKKL NATNYFLMSLAIADML+G LVMP+S+L
Sbjct: 53 QNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLL 112
Query: 134 TILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAF 193
ILY Y WPLP LC VWI LDVLFSTASIMHLCAISLDRYVAI+NPI HSRFNSRTKA
Sbjct: 113 AILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAI 172
Query: 194 LKIIAVWTISVGISMPIPVFGLQDDSKVF-KEGSCLLADDNFVLIGSFVSFFIPLTIMVI 252
+KI VW IS+G+S+PIPV GL+D+ KVF +C+L D NFVLIGSFV+FFIPLTIMVI
Sbjct: 173 MKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVI 232
Query: 253 TYFLTIKSLQKEATLCVSDLGTRAKLASFSFL--------PQSSLSSEKLFQRSIHREPG 304
TY LTI L+++A + + S FL + + ++ Q + R+
Sbjct: 233 TYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKK 292
Query: 305 SYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNV 364
R TMQ+I+NE+KA KVLGIVFF+F++MWCPFFITNI++V+C++SCN+ ++ LLNV
Sbjct: 293 ERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNV 352
Query: 365 FVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYK-ENKKPLQLILVNTIPALAYKSSQ 423
FVWIGY+ S +NPLVYTLFNK YR AFS Y++C YK E K P++ I AL+ +
Sbjct: 353 FVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELN 412
Query: 424 LQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV 471
+ + + N K +DN+ + + + E + S V+E++S V
Sbjct: 413 VNIYRHTNEPVIEKASDNEPGIEM--QVENLELPVNPSSVVSERISSV 458
>gi|222080049 5-hydroxytryptamine (serotonin) receptor 2B [Homo
sapiens]
Length = 481
Score = 358 bits (919), Expect = 6e-99
Identities = 186/350 (53%), Positives = 245/350 (70%), Gaps = 22/350 (6%)
Query: 75 NWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLT 134
+W+ALL +VII TI GN LVI+AVSLEKKLQ ATNYFLMSLA+AD+L+G VMP+++LT
Sbjct: 55 HWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLT 114
Query: 135 ILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFL 194
I++ WPLP LC W++LDVLFSTASIMHLCAIS+DRY+AI+ PI +++NSR AF+
Sbjct: 115 IMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFI 174
Query: 195 KIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD---NFVLIGSFVSFFIPLTIMV 251
KI VW IS+GI++P+P+ G++ D +C+L + +F+L GS +FF PL IM+
Sbjct: 175 KITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMI 234
Query: 252 ITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSS----LSSEKLFQRSIHREP---- 303
+TYFLTI +LQK+A L + R + S + Q S EK+ R+
Sbjct: 235 VTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALP 294
Query: 304 ----------GSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESC 353
S G++++Q+ISNEQ+A KVLGIVFFLF++MWCPFFITNI V+C +SC
Sbjct: 295 NSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLC-DSC 353
Query: 354 NEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENK 403
N+ + LL +FVWIGY+SS VNPLVYTLFNKT+R AF RYI C Y+ K
Sbjct: 354 NQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATK 403
>gi|4504537 5-hydroxytryptamine (serotonin) receptor 1E [Homo
sapiens]
Length = 365
Score = 186 bits (472), Expect = 4e-47
Identities = 118/361 (32%), Positives = 183/361 (50%), Gaps = 50/361 (13%)
Query: 71 LQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 130
+ EK + V+ LT N+ VIMA+ KKL NY + SLA+ D+L+ LVMP+
Sbjct: 19 ITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPL 78
Query: 131 SMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRT 190
S++ I+ RW L LC VW+ +D+ T SI+HLC I+LDRY AI N I ++R +
Sbjct: 79 SIIYIVMD-RWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAK 137
Query: 191 KAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDN--FVLIGSFVSFFIPLT 248
+A L I+ VWTIS+ ISMP P+F C + D+ + + + +F+IPLT
Sbjct: 138 RAALMILTVWTISIFISMP-PLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLT 196
Query: 249 IMVITYFL---TIKSLQKE------------------------ATLCVSDLGTRAKLASF 281
+++I Y+ KSL ++ T CVSD T F
Sbjct: 197 LILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEF 256
Query: 282 SFLPQSSLSSEKLFQRSIHREPG----SYTGRRTMQSISNEQKACKVLGIVFFLFVVMWC 337
+ F SI P + G R S + E+KA ++LG++ F++ W
Sbjct: 257 -----------EKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWL 305
Query: 338 PFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQC 397
PFFI ++ + + + +V L W+GY++S +NPL+YT FN+ ++ AF + I+C
Sbjct: 306 PFFIKELIVGLSIYTVSSEVADFL----TWLGYVNSLINPLLYTSFNEDFKLAFKKLIRC 361
Query: 398 Q 398
+
Sbjct: 362 R 362
>gi|10880131 5-hydroxytryptamine receptor 7 isoform b [Homo sapiens]
Length = 432
Score = 177 bits (448), Expect = 2e-44
Identities = 108/337 (32%), Positives = 181/337 (53%), Gaps = 23/337 (6%)
Query: 80 LTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGY 139
+ ++ +LTIAGN LV+++V KKL+ +NY ++SLA+AD+ + VMP +T L G
Sbjct: 87 ILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGG 146
Query: 140 RWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHS-RFNSRTKAFLKIIA 198
+W C V+I +DV+ TASIM LC IS+DRY+ I P+ + R N + A + I++
Sbjct: 147 KWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKM-ILS 205
Query: 199 VWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD-NFVLIGSFVSFFIPLTIMVITYFLT 257
VW +S I++P P+FG + V + CL++ D + + + V+F+IP+++M+ Y+
Sbjct: 206 VWLLSASITLP-PLFGWAQN--VNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQI 262
Query: 258 IKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSS-------EKLFQRSIHREPGSYTGRR 310
K+ +K A + K F + S+ + +K + + R+
Sbjct: 263 YKAARKSA--------AKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERK 314
Query: 311 TMQSISNEQKACKVLGIVFFLFVVMWCPFF-ITNIMAVICKESCNEDVIGALLNVFVWIG 369
+ EQKA LGI+ F V W PFF ++ IC SC+ + + F+W+G
Sbjct: 315 NISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLW-VERTFLWLG 373
Query: 370 YLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPL 406
Y +S +NP +Y FN+ R+ + +QCQY+ + L
Sbjct: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKL 410
>gi|10880129 5-hydroxytryptamine receptor 7 isoform d [Homo sapiens]
Length = 479
Score = 177 bits (448), Expect = 2e-44
Identities = 108/337 (32%), Positives = 181/337 (53%), Gaps = 23/337 (6%)
Query: 80 LTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGY 139
+ ++ +LTIAGN LV+++V KKL+ +NY ++SLA+AD+ + VMP +T L G
Sbjct: 87 ILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGG 146
Query: 140 RWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHS-RFNSRTKAFLKIIA 198
+W C V+I +DV+ TASIM LC IS+DRY+ I P+ + R N + A + I++
Sbjct: 147 KWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKM-ILS 205
Query: 199 VWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD-NFVLIGSFVSFFIPLTIMVITYFLT 257
VW +S I++P P+FG + V + CL++ D + + + V+F+IP+++M+ Y+
Sbjct: 206 VWLLSASITLP-PLFGWAQN--VNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQI 262
Query: 258 IKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSS-------EKLFQRSIHREPGSYTGRR 310
K+ +K A + K F + S+ + +K + + R+
Sbjct: 263 YKAARKSA--------AKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERK 314
Query: 311 TMQSISNEQKACKVLGIVFFLFVVMWCPFF-ITNIMAVICKESCNEDVIGALLNVFVWIG 369
+ EQKA LGI+ F V W PFF ++ IC SC+ + + F+W+G
Sbjct: 315 NISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLW-VERTFLWLG 373
Query: 370 YLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPL 406
Y +S +NP +Y FN+ R+ + +QCQY+ + L
Sbjct: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKL 410
>gi|4504547 5-hydroxytryptamine receptor 7 isoform a [Homo sapiens]
Length = 445
Score = 177 bits (448), Expect = 2e-44
Identities = 108/337 (32%), Positives = 181/337 (53%), Gaps = 23/337 (6%)
Query: 80 LTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGY 139
+ ++ +LTIAGN LV+++V KKL+ +NY ++SLA+AD+ + VMP +T L G
Sbjct: 87 ILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGG 146
Query: 140 RWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHS-RFNSRTKAFLKIIA 198
+W C V+I +DV+ TASIM LC IS+DRY+ I P+ + R N + A + I++
Sbjct: 147 KWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKM-ILS 205
Query: 199 VWTISVGISMPIPVFGLQDDSKVFKEGSCLLADD-NFVLIGSFVSFFIPLTIMVITYFLT 257
VW +S I++P P+FG + V + CL++ D + + + V+F+IP+++M+ Y+
Sbjct: 206 VWLLSASITLP-PLFGWAQN--VNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQI 262
Query: 258 IKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSS-------EKLFQRSIHREPGSYTGRR 310
K+ +K A + K F + S+ + +K + + R+
Sbjct: 263 YKAARKSA--------AKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERK 314
Query: 311 TMQSISNEQKACKVLGIVFFLFVVMWCPFF-ITNIMAVICKESCNEDVIGALLNVFVWIG 369
+ EQKA LGI+ F V W PFF ++ IC SC+ + + F+W+G
Sbjct: 315 NISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLW-VERTFLWLG 373
Query: 370 YLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPL 406
Y +S +NP +Y FN+ R+ + +QCQY+ + L
Sbjct: 374 YANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKL 410
>gi|4504535 5-hydroxytryptamine (serotonin) receptor 1D [Homo
sapiens]
Length = 377
Score = 174 bits (440), Expect = 2e-43
Identities = 107/338 (31%), Positives = 179/338 (52%), Gaps = 28/338 (8%)
Query: 78 ALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILY 137
A++ +V+ + T+ N V+ + L +KL NY + SLA D+L+ LVMP+S+ +
Sbjct: 42 AVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTIT 101
Query: 138 GYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKII 197
+ W LC +W+ D+ TASI+HLC I+LDRY AI + + +S+ + A I
Sbjct: 102 -HTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIA 160
Query: 198 AVWTISVGISMPIPVFGLQDDSKVFKEGS-CLL--ADDNFVLIGSFVSFFIPLTIMVITY 254
VW IS+ IS+P P+F Q +K +E S CL+ + ++ + + +F+IP +++I Y
Sbjct: 161 IVWAISICISIP-PLFWRQ--AKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILY 217
Query: 255 FLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTG------ 308
++ + S G R A + S+ SS S+H G
Sbjct: 218 GRIYRAARNRILNPPSLYGKRFTTA--HLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFN 275
Query: 309 -----------RRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDV 357
R S + E+KA K+LGI+ F++ W PFF+ +++ IC++SC +
Sbjct: 276 HVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSC--WI 333
Query: 358 IGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYI 395
AL + F W+GYL+S +NP++YT+FN+ +R AF + +
Sbjct: 334 HPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIV 371
>gi|4501959 alpha-1B-adrenergic receptor [Homo sapiens]
Length = 520
Score = 174 bits (440), Expect = 2e-43
Identities = 117/381 (30%), Positives = 194/381 (50%), Gaps = 31/381 (8%)
Query: 31 DFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIA 90
D ++G NTS +W + +N S S L L + L+ I+ I
Sbjct: 4 DLDTGH-NTSAPAHWG-ELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIV 61
Query: 91 GNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAV 150
GNILVI++V+ + L+ TNYF+++LA+AD+LL F V+P S + GY W L C +
Sbjct: 62 GNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGY-WVLGRIFCDI 120
Query: 151 WIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPI 210
W +DVL TASI+ LCAIS+DRY+ ++ + + +R KA L +++VW +S IS+
Sbjct: 121 WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIG- 179
Query: 211 PVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITY---FLTIKSLQKEATL 267
P+ G ++ + + + + + L S SF+IPL ++++ Y ++ K K
Sbjct: 180 PLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNL-- 237
Query: 268 CVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYT---GRRTMQSI-------SN 317
+ G ++++ S + ++ ++ H + S T G SI S
Sbjct: 238 ---EAGVMKEMSN------SKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSR 288
Query: 318 EQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNP 377
E+KA K LGIV +F++ W PFFI + + D A+ V W+GY +S +NP
Sbjct: 289 EKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPD---AVFKVVFWLGYFNSCLNP 345
Query: 378 LVYTLFNKTYRSAFSRYIQCQ 398
++Y +K ++ AF R + CQ
Sbjct: 346 IIYPCSSKEFKRAFVRILGCQ 366
>gi|4504545 5-hydroxytryptamine (serotonin) receptor 6 [Homo
sapiens]
Length = 440
Score = 172 bits (436), Expect = 6e-43
Identities = 106/326 (32%), Positives = 171/326 (52%), Gaps = 20/326 (6%)
Query: 76 WSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTI 135
W A VVI LT A N L+I + + L+N +N+FL+SL +D+++G +VMP +ML
Sbjct: 28 WVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNA 87
Query: 136 LYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLK 195
LYG RW L LC +W DV+ +ASI++LC ISLDRY+ I +P+ + + +A
Sbjct: 88 LYG-RWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALAL 146
Query: 196 IIAVWTISVGISMPIPVFGLQD--DSKVFKEGSC-LLADDNFVLIGSFVSFFIPLTIMVI 252
++ W+++ S + G + ++ G C LLA FVL+ S ++FF+P +
Sbjct: 147 VLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICF 206
Query: 253 TYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTM 312
TY + + +K+A ++AS + S S R+ S RR
Sbjct: 207 TYCRILLAARKQA----------VQVASLTTGMASQASETLQVPRTPRPGVESADSRRLA 256
Query: 313 QSISNEQ-KACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYL 371
S + KA LGI+ +F V W PFF+ NI+ +C + + L +V W+GY
Sbjct: 257 TKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVC-----DCISPGLFDVLTWLGYC 311
Query: 372 SSAVNPLVYTLFNKTYRSAFSRYIQC 397
+S +NP++Y LF + ++ A R++ C
Sbjct: 312 NSTMNPIIYPLFMRDFKRALGRFLPC 337
>gi|89191863 dopamine receptor D3 isoform e [Homo sapiens]
Length = 367
Score = 172 bits (435), Expect = 8e-43
Identities = 117/383 (30%), Positives = 194/383 (50%), Gaps = 48/383 (12%)
Query: 40 SDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAV 99
S N+T +EN T S + + AL +I+ + GN LV MAV
Sbjct: 8 SGHLNYTCGAENSTGAS-------------QARPHAYYALSYCALILAIVFGNGLVCMAV 54
Query: 100 SLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFS 159
E+ LQ TNY ++SLA+AD+L+ LVMP + + G W C V++ LDV+
Sbjct: 55 LKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMC 114
Query: 160 TASIMHLCAISLDRYVAIQNPIHHSRFNSRT---KAFLKIIAVWTISVGISMPIPVFGLQ 216
TASI++LCAIS+DRY A+ P+H+ ++ + L I AVW ++ +S P+ +FG
Sbjct: 115 TASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPL-LFGFN 173
Query: 217 DDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITY---FLTIKSLQKEATLCVSDLG 273
C +++ +FV+ S VSF++P + V+ Y ++ +K +++ L +
Sbjct: 174 TTG---DPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQ 230
Query: 274 TRAKLASFSFLPQSSLSSE----------KLFQRSIHREPGSY-------TGRRTMQSIS 316
+ F PQ +LS + + Q + PG +T S+
Sbjct: 231 CNSVRPGF---PQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLM 287
Query: 317 --NEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSA 374
E+KA +++ IV F+V W PFF+T+++ C ++C+ V L + W+GY++SA
Sbjct: 288 PLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHC-QTCH--VSPELYSATTWLGYVNSA 344
Query: 375 VNPLVYTLFNKTYRSAFSRYIQC 397
+NP++YT FN +R AF + + C
Sbjct: 345 LNPVIYTTFNIEFRKAFLKILSC 367
>gi|10835197 5-hydroxytryptamine (serotonin) receptor 1F [Homo
sapiens]
Length = 366
Score = 171 bits (434), Expect = 1e-42
Identities = 105/346 (30%), Positives = 185/346 (53%), Gaps = 32/346 (9%)
Query: 78 ALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILY 137
+L + + ++T N LVI A+ + +KL + NY + SLA+ D L+ LVMP S++ I+
Sbjct: 27 SLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVR 86
Query: 138 GYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKII 197
W + +C +W+ +D+ T SI+HL AI+LDRY AI + + ++R + A + I
Sbjct: 87 E-SWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIT 145
Query: 198 AVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFV--LIGSFVSFFIPLTIMVITYF 255
VW ISV ISMP P+F + ++ C++ D+ V + +F +F+IPL +++I Y+
Sbjct: 146 IVWIISVFISMP-PLFWRHQGTS--RDDECIIKHDHIVSTIYSTFGAFYIPLALILILYY 202
Query: 256 ------LTIKSLQKEATLCVSDLGTR---------AKLASFSFLPQSSLSSEKLFQRSIH 300
T+ ++ + + ++ + K S S++ + SLS IH
Sbjct: 203 KIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIH 262
Query: 301 REPGSY--------TGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKES 352
S + RR S + E+KA LG++ FV+ W PFF+ ++ +C +
Sbjct: 263 STVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVC-DK 321
Query: 353 CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQ 398
C + + N W+GYL+S +NPL+YT+FN+ ++ AF + ++C+
Sbjct: 322 CK--ISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCR 365
>gi|4504533 5-hydroxytryptamine (serotonin) receptor 1B [Homo
sapiens]
Length = 390
Score = 171 bits (434), Expect = 1e-42
Identities = 111/344 (32%), Positives = 185/344 (53%), Gaps = 29/344 (8%)
Query: 76 WSALLTAVVIILTIA---GNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSM 132
W LL ++ ++T+A N VI V +KL NY + SLA+ D+L+ LVMP+S
Sbjct: 48 WKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPIST 107
Query: 133 LTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKA 192
+ + G RW L +C W+ D+ TASI+HLC I+LDRY AI + + +S + +A
Sbjct: 108 MYTVTG-RWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRA 166
Query: 193 FLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGS-CLLADDN--FVLIGSFVSFFIPLTI 249
+ I VW S+ IS+P P F Q +K +E S C++ D+ + + + +F+ P +
Sbjct: 167 AVMIALVWVFSISISLP-PFFWRQ--AKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLL 223
Query: 250 MVITY---FLTIKS-LQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGS 305
++ Y ++ +S + K+ TRA+L + S SS++S + E GS
Sbjct: 224 LIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGS 283
Query: 306 --YTGR-----------RTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKES 352
Y + + + E+KA K LGI+ F+V W PFFI +++ ICK++
Sbjct: 284 PVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDA 343
Query: 353 CNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQ 396
C + A+ + F W+GYL+S +NP++YT+ N+ ++ AF + I+
Sbjct: 344 CWFHL--AIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIR 385
>gi|4557265 beta-1-adrenergic receptor [Homo sapiens]
Length = 477
Score = 166 bits (420), Expect = 4e-41
Identities = 114/352 (32%), Positives = 179/352 (50%), Gaps = 41/352 (11%)
Query: 74 KNWSA---LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPV 130
+ W+A LL A++++L +AGN+LVI+A++ +LQ TN F+MSLA AD+++G LV+P
Sbjct: 55 QQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPF 114
Query: 131 SMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRT 190
+++G RW S C +W +DVL TASI LC I+LDRY+AI +P + +R
Sbjct: 115 GATIVVWG-RWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRA 173
Query: 191 KAFLKIIAVWTISVGIS-MPIPVFGLQDDS----KVFKEGSC--LLADDNFVLIGSFVSF 243
+A + VW IS +S +PI + + +S + + + C + + + + S VSF
Sbjct: 174 RARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSF 233
Query: 244 FIPLTIMVITYFLTIKSLQKEATLCVS----DLGTRAKLASFSFLP-------------- 285
++PL IM Y + QK+ S LG A+ S S P
Sbjct: 234 YVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPA 293
Query: 286 QSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIM 345
++ ++ R+ R P R EQKA K LGI+ +F + W PFF+ N++
Sbjct: 294 AAAATAPLANGRAGKRRPSRLVALR-------EQKALKTLGIIMGVFTLCWLPFFLANVV 346
Query: 346 AVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQC 397
+E V L F W+GY +SA NP++Y + +R AF + C
Sbjct: 347 KAFHREL----VPDRLFVFFNWLGYANSAFNPIIYCR-SPDFRKAFQGLLCC 393
>gi|111118990 alpha-1A-adrenergic receptor isoform 4 [Homo sapiens]
Length = 455
Score = 158 bits (399), Expect = 1e-38
Identities = 103/360 (28%), Positives = 184/360 (51%), Gaps = 34/360 (9%)
Query: 84 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPL 143
+I+ + GNILVI++V+ + L + T+Y++++LA+AD+LL V+P S + + GY W
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAF 94
Query: 144 PSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTIS 203
C +W +DVL TASIM LC IS+DRY+ + P+ + ++ + + ++ VW +S
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALS 154
Query: 204 VGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQK 263
+ IS+ P+FG + + + + + +VL + SF++PL I+++ Y ++
Sbjct: 155 LVISIG-PLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKR 213
Query: 264 EATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHRE--PGSYTGRRTMQS------- 314
E+ S L T SE++ R IHR+ P +G + ++
Sbjct: 214 ESRGLKSGLKT------------DKSDSEQVTLR-IHRKNAPAGGSGMASAKTKTHFSVR 260
Query: 315 ---ISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYL 371
S E+KA K LGIV FV+ W PFF+ + + + + + W+GYL
Sbjct: 261 LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETV---FKIVFWLGYL 317
Query: 372 SSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKN 431
+S +NP++Y ++ ++ AF ++ Q K+ + L T+ + SQ GQ K+
Sbjct: 318 NSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL----HPPSQAVEGQHKD 373
>gi|111118992 alpha-1A-adrenergic receptor isoform 1 [Homo sapiens]
Length = 466
Score = 158 bits (399), Expect = 1e-38
Identities = 103/360 (28%), Positives = 184/360 (51%), Gaps = 34/360 (9%)
Query: 84 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPL 143
+I+ + GNILVI++V+ + L + T+Y++++LA+AD+LL V+P S + + GY W
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAF 94
Query: 144 PSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTIS 203
C +W +DVL TASIM LC IS+DRY+ + P+ + ++ + + ++ VW +S
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALS 154
Query: 204 VGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQK 263
+ IS+ P+FG + + + + + +VL + SF++PL I+++ Y ++
Sbjct: 155 LVISIG-PLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKR 213
Query: 264 EATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHRE--PGSYTGRRTMQS------- 314
E+ S L T SE++ R IHR+ P +G + ++
Sbjct: 214 ESRGLKSGLKT------------DKSDSEQVTLR-IHRKNAPAGGSGMASAKTKTHFSVR 260
Query: 315 ---ISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYL 371
S E+KA K LGIV FV+ W PFF+ + + + + + W+GYL
Sbjct: 261 LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETV---FKIVFWLGYL 317
Query: 372 SSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKN 431
+S +NP++Y ++ ++ AF ++ Q K+ + L T+ + SQ GQ K+
Sbjct: 318 NSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL----HPPSQAVEGQHKD 373
>gi|111118986 alpha-1A-adrenergic receptor isoform 2 [Homo sapiens]
Length = 475
Score = 158 bits (399), Expect = 1e-38
Identities = 103/360 (28%), Positives = 184/360 (51%), Gaps = 34/360 (9%)
Query: 84 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPL 143
+I+ + GNILVI++V+ + L + T+Y++++LA+AD+LL V+P S + + GY W
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAF 94
Query: 144 PSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTIS 203
C +W +DVL TASIM LC IS+DRY+ + P+ + ++ + + ++ VW +S
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALS 154
Query: 204 VGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQK 263
+ IS+ P+FG + + + + + +VL + SF++PL I+++ Y ++
Sbjct: 155 LVISIG-PLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKR 213
Query: 264 EATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHRE--PGSYTGRRTMQS------- 314
E+ S L T SE++ R IHR+ P +G + ++
Sbjct: 214 ESRGLKSGLKT------------DKSDSEQVTLR-IHRKNAPAGGSGMASAKTKTHFSVR 260
Query: 315 ---ISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYL 371
S E+KA K LGIV FV+ W PFF+ + + + + + W+GYL
Sbjct: 261 LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETV---FKIVFWLGYL 317
Query: 372 SSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKN 431
+S +NP++Y ++ ++ AF ++ Q K+ + L T+ + SQ GQ K+
Sbjct: 318 NSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL----HPPSQAVEGQHKD 373
>gi|111118988 alpha-1A-adrenergic receptor isoform 3 [Homo sapiens]
Length = 429
Score = 158 bits (399), Expect = 1e-38
Identities = 103/360 (28%), Positives = 184/360 (51%), Gaps = 34/360 (9%)
Query: 84 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPL 143
+I+ + GNILVI++V+ + L + T+Y++++LA+AD+LL V+P S + + GY W
Sbjct: 36 LILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGY-WAF 94
Query: 144 PSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTIS 203
C +W +DVL TASIM LC IS+DRY+ + P+ + ++ + + ++ VW +S
Sbjct: 95 GRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALS 154
Query: 204 VGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQK 263
+ IS+ P+FG + + + + + +VL + SF++PL I+++ Y ++
Sbjct: 155 LVISIG-PLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKR 213
Query: 264 EATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHRE--PGSYTGRRTMQS------- 314
E+ S L T SE++ R IHR+ P +G + ++
Sbjct: 214 ESRGLKSGLKT------------DKSDSEQVTLR-IHRKNAPAGGSGMASAKTKTHFSVR 260
Query: 315 ---ISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYL 371
S E+KA K LGIV FV+ W PFF+ + + + + + W+GYL
Sbjct: 261 LLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETV---FKIVFWLGYL 317
Query: 372 SSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKN 431
+S +NP++Y ++ ++ AF ++ Q K+ + L T+ + SQ GQ K+
Sbjct: 318 NSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTL----HPPSQAVEGQHKD 373
>gi|4503383 dopamine receptor D1 [Homo sapiens]
Length = 446
Score = 157 bits (397), Expect = 2e-38
Identities = 118/408 (28%), Positives = 202/408 (49%), Gaps = 44/408 (10%)
Query: 77 SALLTAVVIILTIAGNILVIMAVSLEKKLQN-ATNYFLMSLAIADMLLGFLVMPVSMLTI 135
+A +++I+ T+ GN LV AV + L++ TN+F++SLA++D+L+ LVMP +
Sbjct: 26 TACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAE 85
Query: 136 LYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLK 195
+ G+ WP S C +W+ D++ STASI++LC IS+DRY AI +P + R + AF+
Sbjct: 86 IAGF-WPFGS-FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFIL 143
Query: 196 IIAVWTISVGIS-MPIPVFGLQDDSKVFKEGSCL-LAD--DN--------FVLIGSFVSF 243
I WT+SV IS +P+ + + +G+ LA+ DN + + S +SF
Sbjct: 144 ISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISF 203
Query: 244 FIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREP 303
+IP+ IM++TY + QK+ + + + A + Q++ + K + S +P
Sbjct: 204 YIPVAIMIVTYTRIYRIAQKQ----IRRIAALERAAVHAKNCQTTTGNGKPVECS---QP 256
Query: 304 GSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNED--VIGAL 361
S S E K K L ++ +FV W PFFI N + C + +
Sbjct: 257 ES----SFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNT 312
Query: 362 LNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQ--YKENKKPLQLILVNTIPALAY 419
+VFVW G+ +S++NP++Y FN +R AFS + C ++ + +N A +
Sbjct: 313 FDVFVWFGWANSSLNPIIYA-FNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMF 371
Query: 420 KSSQLQMGQKKNSKQDAKTTDNDCSMVAL---GKQHSEEASKDNSDGV 464
S G + +C++V L SE+ K+ + G+
Sbjct: 372 SSHHEPRG----------SISKECNLVYLIPHAVGSSEDLKKEEAAGI 409
>gi|4557267 adrenergic, beta-3-, receptor [Homo sapiens]
Length = 408
Score = 155 bits (392), Expect = 7e-38
Identities = 109/348 (31%), Positives = 173/348 (49%), Gaps = 20/348 (5%)
Query: 61 LSPSCLSLLHLQEKNWSALLT----AVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSL 116
L+P+ + L W A L A+ ++ T+ GN+LVI+A++ +LQ TN F+ SL
Sbjct: 20 LAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSL 79
Query: 117 AIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVA 176
A AD+++G LV+P + L G+ WPL + C +W +DVL TASI LCA+++DRY+A
Sbjct: 80 AAADLVMGLLVVPPAATLALTGH-WPLGATGCELWTSVDVLCVTASIETLCALAVDRYLA 138
Query: 177 IQNPIHHSRFNSRTKAFLKIIAVWTISVGISM-PI-----PVFGLQDDSKVFKEGSCLLA 230
+ NP+ + ++ A ++ VW +S +S PI V + + C
Sbjct: 139 VTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAF 198
Query: 231 DDN--FVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSS 288
N +VL+ S VSF++PL +M+ Y ++ L +LG R P S
Sbjct: 199 ASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELG-RFPPEESPPAPSRS 257
Query: 289 LSSEKLFQRSIHREPGSYTGRRTMQSIS-NEQKACKVLGIVFFLFVVMWCPFFITNIMAV 347
L+ + E GRR + + E +A LG++ F + W PFF+ N++
Sbjct: 258 LAPAPV-GTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRA 316
Query: 348 ICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYI 395
+ S V G W+GY +SA NPL+Y + +RSAF R +
Sbjct: 317 LGGPSL---VPGPAFLALNWLGYANSAFNPLIYCR-SPDFRSAFRRLL 360
>gi|13236497 5-hydroxytryptamine receptor 5A [Homo sapiens]
Length = 357
Score = 155 bits (392), Expect = 7e-38
Identities = 93/324 (28%), Positives = 169/324 (52%), Gaps = 16/324 (4%)
Query: 80 LTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGY 139
L ++ T A N+LV+ + + + + S+A++D+L+ LVMP+S++ L G
Sbjct: 46 LLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGR 105
Query: 140 RWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAV 199
RW L +LC +WI DVL TASI ++ AI+LDRY +I + ++ + + + I
Sbjct: 106 RWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALT 165
Query: 200 WTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIK 259
W +S IS+ +FG + E + + ++ + + +F++PL +++ Y+ K
Sbjct: 166 WALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYK 225
Query: 260 SLQ----KEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSI 315
+ + T VS + ++ + PQ + + ++ +P T R
Sbjct: 226 AAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFT---VRHATVTFQPEGDTWRE----- 277
Query: 316 SNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAV 375
EQ+A ++GI+ +FV+ W PFF+T +++ +C SC D+ ++F+W+GY +S
Sbjct: 278 QKEQRAALMVGILIGVFVLCWIPFFLTELISPLC--SC--DIPAIWKSIFLWLGYSNSFF 333
Query: 376 NPLVYTLFNKTYRSAFSRYIQCQY 399
NPL+YT FNK Y SAF + Q+
Sbjct: 334 NPLIYTAFNKNYNSAFKNFFSRQH 357
>gi|4501957 alpha-1D-adrenergic receptor [Homo sapiens]
Length = 572
Score = 154 bits (388), Expect = 2e-37
Identities = 91/329 (27%), Positives = 168/329 (51%), Gaps = 12/329 (3%)
Query: 82 AVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRW 141
A I++ +AGN+LVI++V+ + LQ TNYF+++LA+AD+LL V+P S + G+ W
Sbjct: 104 AAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGF-W 162
Query: 142 PLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWT 201
C VW +DVL TASI+ LC IS+DRYV +++ + + + KA + +W
Sbjct: 163 AFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWV 222
Query: 202 ISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSL 261
+++ +S+ P+ G ++ + + + + + S SF++P+ ++V+ Y + +
Sbjct: 223 VALVVSVG-PLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMY-CRVYVV 280
Query: 262 QKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIH--REPGSYTGRRTMQ----SI 315
+ T + R + + + + H R +T R ++
Sbjct: 281 ARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKF 340
Query: 316 SNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAV 375
S E+KA K L IV +FV+ W PFF + + + + + V W+GY +S V
Sbjct: 341 SREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSE---GVFKVIFWLGYFNSCV 397
Query: 376 NPLVYTLFNKTYRSAFSRYIQCQYKENKK 404
NPL+Y ++ ++ AF R ++CQ + ++
Sbjct: 398 NPLIYPCSSREFKRAFLRLLRCQCRRRRR 426
>gi|4501969 adrenergic, beta-2-, receptor, surface [Homo sapiens]
Length = 413
Score = 150 bits (378), Expect = 3e-36
Identities = 101/325 (31%), Positives = 163/325 (50%), Gaps = 30/325 (9%)
Query: 79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYG 138
++ +++++ + GN+LVI A++ ++LQ TNYF+ SLA AD+++G V+P IL
Sbjct: 38 IVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMK 97
Query: 139 YRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIA 198
W + C W +DVL TASI LC I++DRY AI +P + ++ KA + I+
Sbjct: 98 M-WTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILM 156
Query: 199 VWTISVGISMPIPV------FGLQDDSKVFKEGSC--LLADDNFVLIGSFVSFFIPLTIM 250
VW +S G++ +P+ Q+ + +C + + + S VSF++PL IM
Sbjct: 157 VWIVS-GLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIM 215
Query: 251 VITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRR 310
V Y + +++ G R + + S + Q + L RR
Sbjct: 216 VFVYSRVFQEAKRQLQKIDKSEG-RFHVQNLSQVEQDGRTGHGL--------------RR 260
Query: 311 TMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGY 370
+ + E KA K LGI+ F + W PFFI NI+ VI ++V LLN WIGY
Sbjct: 261 SSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVY-ILLN---WIGY 316
Query: 371 LSSAVNPLVYTLFNKTYRSAFSRYI 395
++S NPL+Y + +R AF +
Sbjct: 317 VNSGFNPLIYCR-SPDFRIAFQELL 340
>gi|197085610 histamine receptor H2 isoform 1 [Homo sapiens]
Length = 397
Score = 149 bits (377), Expect = 4e-36
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 48/326 (14%)
Query: 79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYG 138
++ AV+I++T+AGN++V +AV L ++L+N TN F++SLAI D+LLG LV+P S + L
Sbjct: 23 VVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQL-S 81
Query: 139 YRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIA 198
+W C ++ LDV+ TASI++L ISLDRY A+ +P+ + + + + ++
Sbjct: 82 CKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVL 141
Query: 199 VWTISVGISMPIPVFGLQDDSKVFK----EGSC-LLADDNFVLIGSFVSFFIPLTIMVIT 253
+W IS+ +S G ++ K C + ++ + L+ V+F++PL IM IT
Sbjct: 142 IWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCIT 201
Query: 254 YFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQ 313
Y+ K + +A + +SS K
Sbjct: 202 YYRIFKVARDQAKRI------------------NHISSWK-------------------A 224
Query: 314 SISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFV-WIGYLS 372
+ E KA L V F++ W P+F A + + +D I +L V W+GY +
Sbjct: 225 ATIREHKATVTLAAVMGAFIICWFPYF----TAFVYRGLRGDDAINEVLEAIVLWLGYAN 280
Query: 373 SAVNPLVYTLFNKTYRSAFSRYIQCQ 398
SA+NP++Y N+ +R+ + + C+
Sbjct: 281 SALNPILYAALNRDFRTGYQQLFCCR 306
>gi|13435405 histamine receptor H2 isoform 2 [Homo sapiens]
Length = 359
Score = 149 bits (377), Expect = 4e-36
Identities = 94/326 (28%), Positives = 163/326 (50%), Gaps = 48/326 (14%)
Query: 79 LLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYG 138
++ AV+I++T+AGN++V +AV L ++L+N TN F++SLAI D+LLG LV+P S + L
Sbjct: 23 VVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQL-S 81
Query: 139 YRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIA 198
+W C ++ LDV+ TASI++L ISLDRY A+ +P+ + + + + ++
Sbjct: 82 CKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVL 141
Query: 199 VWTISVGISMPIPVFGLQDDSKVFK----EGSC-LLADDNFVLIGSFVSFFIPLTIMVIT 253
+W IS+ +S G ++ K C + ++ + L+ V+F++PL IM IT
Sbjct: 142 IWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCIT 201
Query: 254 YFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQ 313
Y+ K + +A + +SS K
Sbjct: 202 YYRIFKVARDQAKRI------------------NHISSWK-------------------A 224
Query: 314 SISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFV-WIGYLS 372
+ E KA L V F++ W P+F A + + +D I +L V W+GY +
Sbjct: 225 ATIREHKATVTLAAVMGAFIICWFPYF----TAFVYRGLRGDDAINEVLEAIVLWLGYAN 280
Query: 373 SAVNPLVYTLFNKTYRSAFSRYIQCQ 398
SA+NP++Y N+ +R+ + + C+
Sbjct: 281 SALNPILYAALNRDFRTGYQQLFCCR 306
>gi|94421462 serotonin 5-HT4 receptor isoform n [Homo sapiens]
Length = 359
Score = 148 bits (374), Expect = 9e-36
Identities = 112/349 (32%), Positives = 176/349 (50%), Gaps = 45/349 (12%)
Query: 82 AVVIILTIAGNILVIMAVSLEKKLQNA-TNYFLMSLAIADMLLGFLVMPVSMLTILYGYR 140
+ VI++ I GN+LV++AV +++L+ TNYF++SLA AD+L+ LVMP + ++
Sbjct: 27 STVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI- 85
Query: 141 WPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAI-QNPIHHSRFNSRTKAFLKIIAV 199
W C V LDVL +TASI HLC ISLDRY AI P+ + + + L +
Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145
Query: 200 WTISVGISMPIPV------FGLQD--DSKVFKEGS-----CLLADDNFVLIGSFVSFFIP 246
W I IS +P+ G+ D + + F + S + + + + S V+F+IP
Sbjct: 146 WVIPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIP 204
Query: 247 LTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSY 306
+MV+ Y+ + ++ A + RA +S S PQS+ Q S HR
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQI--QMLQRAGASSES-RPQSA------DQHSTHR----- 250
Query: 307 TGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFV 366
+ E KA K L I+ F + W PFF+TNI+ + V G + F+
Sbjct: 251 --------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIV----DPFIDYTVPGQVWTAFL 298
Query: 367 WIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIP 415
W+GY++S +NP +Y NK++R AF + C + ++P IL T+P
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP--SILGQTVP 345
>gi|94421460 serotonin 5-HT4 receptor isoform i [Homo sapiens]
Length = 428
Score = 148 bits (374), Expect = 9e-36
Identities = 112/349 (32%), Positives = 176/349 (50%), Gaps = 45/349 (12%)
Query: 82 AVVIILTIAGNILVIMAVSLEKKLQNA-TNYFLMSLAIADMLLGFLVMPVSMLTILYGYR 140
+ VI++ I GN+LV++AV +++L+ TNYF++SLA AD+L+ LVMP + ++
Sbjct: 27 STVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI- 85
Query: 141 WPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAI-QNPIHHSRFNSRTKAFLKIIAV 199
W C V LDVL +TASI HLC ISLDRY AI P+ + + + L +
Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145
Query: 200 WTISVGISMPIPV------FGLQD--DSKVFKEGS-----CLLADDNFVLIGSFVSFFIP 246
W I IS +P+ G+ D + + F + S + + + + S V+F+IP
Sbjct: 146 WVIPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIP 204
Query: 247 LTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSY 306
+MV+ Y+ + ++ A + RA +S S PQS+ Q S HR
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQI--QMLQRAGASSES-RPQSA------DQHSTHR----- 250
Query: 307 TGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFV 366
+ E KA K L I+ F + W PFF+TNI+ + V G + F+
Sbjct: 251 --------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIV----DPFIDYTVPGQVWTAFL 298
Query: 367 WIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIP 415
W+GY++S +NP +Y NK++R AF + C + ++P IL T+P
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP--SILGQTVP 345
>gi|94421456 serotonin 5-HT4 receptor isoform d [Homo sapiens]
Length = 360
Score = 148 bits (374), Expect = 9e-36
Identities = 112/349 (32%), Positives = 176/349 (50%), Gaps = 45/349 (12%)
Query: 82 AVVIILTIAGNILVIMAVSLEKKLQNA-TNYFLMSLAIADMLLGFLVMPVSMLTILYGYR 140
+ VI++ I GN+LV++AV +++L+ TNYF++SLA AD+L+ LVMP + ++
Sbjct: 27 STVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI- 85
Query: 141 WPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAI-QNPIHHSRFNSRTKAFLKIIAV 199
W C V LDVL +TASI HLC ISLDRY AI P+ + + + L +
Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145
Query: 200 WTISVGISMPIPV------FGLQD--DSKVFKEGS-----CLLADDNFVLIGSFVSFFIP 246
W I IS +P+ G+ D + + F + S + + + + S V+F+IP
Sbjct: 146 WVIPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIP 204
Query: 247 LTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSY 306
+MV+ Y+ + ++ A + RA +S S PQS+ Q S HR
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQI--QMLQRAGASSES-RPQSA------DQHSTHR----- 250
Query: 307 TGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFV 366
+ E KA K L I+ F + W PFF+TNI+ + V G + F+
Sbjct: 251 --------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIV----DPFIDYTVPGQVWTAFL 298
Query: 367 WIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIP 415
W+GY++S +NP +Y NK++R AF + C + ++P IL T+P
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP--SILGQTVP 345
>gi|94421454 serotonin 5-HT4 receptor isoform a [Homo sapiens]
Length = 387
Score = 148 bits (374), Expect = 9e-36
Identities = 112/349 (32%), Positives = 176/349 (50%), Gaps = 45/349 (12%)
Query: 82 AVVIILTIAGNILVIMAVSLEKKLQNA-TNYFLMSLAIADMLLGFLVMPVSMLTILYGYR 140
+ VI++ I GN+LV++AV +++L+ TNYF++SLA AD+L+ LVMP + ++
Sbjct: 27 STVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI- 85
Query: 141 WPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAI-QNPIHHSRFNSRTKAFLKIIAV 199
W C V LDVL +TASI HLC ISLDRY AI P+ + + + L +
Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145
Query: 200 WTISVGISMPIPV------FGLQD--DSKVFKEGS-----CLLADDNFVLIGSFVSFFIP 246
W I IS +P+ G+ D + + F + S + + + + S V+F+IP
Sbjct: 146 WVIPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIP 204
Query: 247 LTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSY 306
+MV+ Y+ + ++ A + RA +S S PQS+ Q S HR
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQI--QMLQRAGASSES-RPQSA------DQHSTHR----- 250
Query: 307 TGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFV 366
+ E KA K L I+ F + W PFF+TNI+ + V G + F+
Sbjct: 251 --------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIV----DPFIDYTVPGQVWTAFL 298
Query: 367 WIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIP 415
W+GY++S +NP +Y NK++R AF + C + ++P IL T+P
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP--SILGQTVP 345
>gi|41282074 serotonin 5-HT4 receptor isoform g [Homo sapiens]
Length = 378
Score = 148 bits (374), Expect = 9e-36
Identities = 112/349 (32%), Positives = 176/349 (50%), Gaps = 45/349 (12%)
Query: 82 AVVIILTIAGNILVIMAVSLEKKLQNA-TNYFLMSLAIADMLLGFLVMPVSMLTILYGYR 140
+ VI++ I GN+LV++AV +++L+ TNYF++SLA AD+L+ LVMP + ++
Sbjct: 27 STVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDI- 85
Query: 141 WPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAI-QNPIHHSRFNSRTKAFLKIIAV 199
W C V LDVL +TASI HLC ISLDRY AI P+ + + + L +
Sbjct: 86 WIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGC 145
Query: 200 WTISVGISMPIPV------FGLQD--DSKVFKEGS-----CLLADDNFVLIGSFVSFFIP 246
W I IS +P+ G+ D + + F + S + + + + S V+F+IP
Sbjct: 146 WVIPTFISF-LPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIP 204
Query: 247 LTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSY 306
+MV+ Y+ + ++ A + RA +S S PQS+ Q S HR
Sbjct: 205 FLLMVLAYYRIYVTAKEHAHQI--QMLQRAGASSES-RPQSA------DQHSTHR----- 250
Query: 307 TGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFV 366
+ E KA K L I+ F + W PFF+TNI+ + V G + F+
Sbjct: 251 --------MRTETKAAKTLCIIMGCFCLCWAPFFVTNIV----DPFIDYTVPGQVWTAFL 298
Query: 367 WIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIP 415
W+GY++S +NP +Y NK++R AF + C + ++P IL T+P
Sbjct: 299 WLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRP--SILGQTVP 345
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.134 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,875,015
Number of Sequences: 37866
Number of extensions: 633325
Number of successful extensions: 3508
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 580
Number of HSP's successfully gapped in prelim test: 169
Number of HSP's that attempted gapping in prelim test: 1586
Number of HSP's gapped (non-prelim): 1283
length of query: 471
length of database: 18,247,518
effective HSP length: 106
effective length of query: 365
effective length of database: 14,233,722
effective search space: 5195308530
effective search space used: 5195308530
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.