Guide to the Human Genome
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Search of human proteins with 10835173

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
         (1434 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]         2928   0.0  
gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]         1392   0.0  
gi|24041029 nitric oxide synthase 2A [Homo sapiens]                  1232   0.0  
gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]         731   0.0  
gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]         724   0.0  
gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]         724   0.0  
gi|127139033 cytochrome P450 reductase [Homo sapiens]                 246   9e-65
gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]   218   3e-56
gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]   218   3e-56
gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [...   192   3e-48
gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a...   188   4e-47
gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c...   183   9e-46
gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d...   154   8e-37
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i...    58   6e-08
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i...    58   6e-08
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i...    58   6e-08
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is...    58   6e-08
gi|11321640 basic beta 1 syntrophin [Homo sapiens]                     57   1e-07
gi|5803177 basic beta 2 syntrophin [Homo sapiens]                      57   1e-07
gi|87196343 PDZ domain containing 2 [Homo sapiens]                     56   3e-07
gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]                    55   5e-07
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora...    54   1e-06
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora...    54   1e-06
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora...    54   1e-06
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      54   1e-06
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      54   1e-06
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       54   1e-06
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa...    54   1e-06
gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo sa...    54   1e-06
gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo sap...    54   1e-06

>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
          Length = 1434

 Score = 2928 bits (7590), Expect = 0.0
 Identities = 1434/1434 (100%), Positives = 1434/1434 (100%)

Query: 1    MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA 60
            MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
Sbjct: 1    MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA 60

Query: 61   GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI 120
            GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
Sbjct: 61   GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI 120

Query: 121  RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP 180
            RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP
Sbjct: 121  RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP 180

Query: 181  RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV 240
            RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV
Sbjct: 181  RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV 240

Query: 241  DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS 300
            DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS
Sbjct: 241  DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS 300

Query: 301  KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF 360
            KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF
Sbjct: 301  KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF 360

Query: 361  PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC 420
            PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC
Sbjct: 361  PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC 420

Query: 421  VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW 480
            VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW
Sbjct: 421  VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW 480

Query: 481  NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ 540
            NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ
Sbjct: 481  NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ 540

Query: 541  IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV 600
            IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV
Sbjct: 541  IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV 600

Query: 601  RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT 660
            RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT
Sbjct: 601  RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT 660

Query: 661  ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV 720
            ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV
Sbjct: 661  ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV 720

Query: 721  WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE 780
            WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE
Sbjct: 721  WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE 780

Query: 781  IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ 840
            IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ
Sbjct: 781  IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ 840

Query: 841  EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF 900
            EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF
Sbjct: 841  EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF 900

Query: 901  GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN 960
            GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN
Sbjct: 901  GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN 960

Query: 961  SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV 1020
            SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV
Sbjct: 961  SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV 1020

Query: 1021 RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV 1080
            RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV
Sbjct: 1021 RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV 1080

Query: 1081 ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY 1140
            ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY
Sbjct: 1081 ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY 1140

Query: 1141 EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV 1200
            EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV
Sbjct: 1141 EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV 1200

Query: 1201 SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP 1260
            SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP
Sbjct: 1201 SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP 1260

Query: 1261 FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE 1320
            FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE
Sbjct: 1261 FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE 1320

Query: 1321 PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE 1380
            PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE
Sbjct: 1321 PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE 1380

Query: 1381 DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS 1434
            DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
Sbjct: 1381 DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS 1434


>gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]
          Length = 1203

 Score = 1392 bits (3603), Expect = 0.0
 Identities = 678/1149 (59%), Positives = 853/1149 (74%), Gaps = 17/1149 (1%)

Query: 278  PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337
            P + +  PP+S    P +       P+F +VKNWE   +  DTL  ++  +  CT   C+
Sbjct: 47   PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100

Query: 338  GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396
            GS++ P +   RP        QL   A++FI+QYYSSIKR GS+AH +RL+EV  E+  T
Sbjct: 101  GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160

Query: 397  STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456
             TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A  MF YICNH+KYATN
Sbjct: 161  GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220

Query: 457  KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516
            +GNLRSAIT+FPQR  G+ DFR+WNSQL+RYAGY+Q DGS  GDPANV+ TE+CIQ GW 
Sbjct: 221  RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280

Query: 517  PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576
            P  GRFDVLPLLLQA  + PELF +PPELVLEVP+ HP  EWF  LGL+WY LPAVSNML
Sbjct: 281  PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340

Query: 577  LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636
            LEIGGLEF A PFSGWYM TEIG R+ CD  RYNILE+VA  M+LD R TSSLWKD+A V
Sbjct: 341  LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400

Query: 637  EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696
            EIN+AVL+S+Q  KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF
Sbjct: 401  EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460

Query: 697  HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756
            HQEM+NY L+P+F YQPDPW     KGT  T  K     FK++A AVK SA LMG  MAK
Sbjct: 461  HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516

Query: 757  RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816
            RVKATILY +ETG++Q+YA+ L  +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN
Sbjct: 517  RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576

Query: 817  GDPPENGEKFGCALMEMRHPNSVQ---EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNF 873
            GDPPENGE F  ALMEM  P +     E+ KSYK+RFNS+S       S         N 
Sbjct: 577  GDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNT 636

Query: 874  ESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFR 933
            +SAG L  +RF VFGLGSRAYPHFCAF  AVDT LEELGGER+L++ +GDELCGQEEAFR
Sbjct: 637  DSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFR 696

Query: 934  TWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVH 993
             WA+  F+AAC+ FCVG+D   + A   + S  RSWKR ++RL+  AE  +L  GL +VH
Sbjct: 697  GWAQAAFQAACETFCVGEDA--KAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVH 754

Query: 994  KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALI 1053
            ++++  A + S +NLQS KS+R+TI VRL T G + LQYQPGDH+GV P N   LV AL+
Sbjct: 755  RRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALL 814

Query: 1054 ERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQ 1113
             R+ED P   + V VE LE+ +   G    W  + RLPPCT+ QA  ++LDIT+PP+P  
Sbjct: 815  SRVEDPPAPTEPVAVEQLEKGSPG-GPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQL 873

Query: 1114 LQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLS 1173
            L+  ++LA   +E+Q L  LS+  + YEEWKW + PT++EVLE+FPS+ +PA LLLTQL 
Sbjct: 874  LRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLP 933

Query: 1174 LLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADELVPCFV 1233
            LLQPRYYS+SS+P  +P E+HLTVA+++YRT+DG GP+H+GVCS+WL++++  + VPCF+
Sbjct: 934  LLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFI 993

Query: 1234 RGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKI 1293
            RGAPSF LP +P +PCILVGPGTGIAPFR FWQ+R  DI+ KG+ P PM LVFGCR S++
Sbjct: 994  RGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFGCRCSQL 1053

Query: 1294 DHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQGGHIYV 1353
            DH+YR+E   A+ +GVF  + TA+SREPD PK YVQDIL+ +LA  V+R L  + GH++V
Sbjct: 1054 DHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERGHMFV 1113

Query: 1354 CGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRL 1413
            CGDVTMA +VL+ +QRI+  +G +  ++AG  I  +RD  RYHEDIFG+TLRT EVT+R+
Sbjct: 1114 CGDVTMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRI 1173

Query: 1414 RSESIAFIE 1422
            R++S +  E
Sbjct: 1174 RTQSFSLQE 1182


>gi|24041029 nitric oxide synthase 2A [Homo sapiens]
          Length = 1153

 Score = 1232 bits (3187), Expect = 0.0
 Identities = 615/1133 (54%), Positives = 779/1133 (68%), Gaps = 58/1133 (5%)

Query: 275  LNNPYSEKEQPPT-SGKQSPTK----NGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLET 329
            L+   +E  QP   +GK+SP      + +P   PR +++KNW + +   DTLH K+    
Sbjct: 49   LSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGIL 108

Query: 330  GCTEYICMGSIMHPSQHARRPEDVRTK-GQLFPLAKEFIDQYYSSIKRFGSKAHMERLEE 388
             C    C+GSIM P    R P D  T   +L P A EF++QYY S K    + H+ R+E 
Sbjct: 109  TCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEA 168

Query: 389  VNKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYIC 448
            V KEI+TT TYQL   ELI+  K AWRNA RC+GRIQWS LQVFDAR C+TA  MF +IC
Sbjct: 169  VTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHIC 228

Query: 449  NHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTE 508
             HV+Y+TN GN+RSAIT+FPQR+DGKHDFRVWN+QLIRYAGY+ PDGS  GDPANV+FT+
Sbjct: 229  RHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQ 288

Query: 509  ICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYG 568
            +CI  GWKP  GRFDV+PL+LQANG DPELF+IPP+LVLEV + HPK+EWF++L LKWY 
Sbjct: 289  LCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYA 348

Query: 569  LPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSS 628
            LPAV+NMLLE+GGLEF  CPF+GWYMGTEIGVRD+CD  RYNILEEV ++M L+  K +S
Sbjct: 349  LPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLAS 408

Query: 629  LWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPM 688
            LWKDQA+VEINIAVL+SFQ   VTI+DHHSA ESF+K+M+NEYR RGGCPADW+W+VPPM
Sbjct: 409  LWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPM 468

Query: 689  SGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAK 748
            SGSITPVFHQEMLNY L+P + YQ + W THVW+     P KRR I  K L +AV F+  
Sbjct: 469  SGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRP-KRREIPLKVLVKAVLFACM 527

Query: 749  LMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVL 808
            LM + MA RV+ TIL+ATETGKS+A A  L  +F  AF+ KV+ M++Y +  LE E L+L
Sbjct: 528  LMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLL 587

Query: 809  VVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPD 868
            VVTSTFGNGD P NGEK   +L  ++  N+                              
Sbjct: 588  VVTSTFGNGDCPGNGEKLKKSLFMLKELNN------------------------------ 617

Query: 869  LRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQ 928
                          R++VFGLGS  YP FCAF H +D  L  LG  ++  M EGDEL GQ
Sbjct: 618  ------------KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQ 665

Query: 929  EEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQG 988
            E+AFR+WA + FKAAC+ F V    +I+     L +++ +W  + +RL   ++  +L++ 
Sbjct: 666  EDAFRSWAVQTFKAACETFDVRGKQHIQIP--KLYTSNVTWDPHHYRLVQDSQPLDLSKA 723

Query: 989  LSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDL 1048
            LS++H K V   RL SRQNLQSP SSR+TI V L     Q L Y PG+HLGV PGN   L
Sbjct: 724  LSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPAL 783

Query: 1049 VNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTP 1108
            V  ++ER+ D P  +Q V++E L+E        S W  + RLPPC++ QA  Y+LDITTP
Sbjct: 784  VQGILERVVDGPTPHQTVRLEALDESG------SYWVSDKRLPPCSLSQALTYFLDITTP 837

Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLL 1168
            PT L LQ+ A +AT E E+QRL  L +   EY +WK+  +PT +EVLEEFPS+++ A  L
Sbjct: 838  PTQLLLQKLAQVATEEPERQRLEALCQP-SEYSKWKFTNSPTFLEVLEEFPSLRVSAGFL 896

Query: 1169 LTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADEL 1228
            L+QL +L+PR+YSISSS D  P E+HLTVA+V+Y TRDG+GP+HHGVCS+WLN ++  + 
Sbjct: 897  LSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDP 956

Query: 1229 VPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGC 1288
            VPCFVR A  FHLP +P  PCIL+GPGTGIAPFRSFWQQR  D QHKG+    M LVFGC
Sbjct: 957  VPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGC 1016

Query: 1289 RQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQG 1348
            R+   DHIY+EE L+   KGV   ++TAYSR P KPK YVQDIL++QLA  V R L ++ 
Sbjct: 1017 RRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEP 1076

Query: 1349 GHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFG 1401
            GH+YVCGDV MA DV   +++++  + KL+ E    +  +++   RYHEDIFG
Sbjct: 1077 GHLYVCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFG 1129


>gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]
          Length = 614

 Score =  731 bits (1887), Expect = 0.0
 Identities = 354/562 (62%), Positives = 427/562 (75%), Gaps = 11/562 (1%)

Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337
           P + +  PP+S    P +       P+F +VKNWE   +  DTL  ++  +  CT   C+
Sbjct: 47  PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100

Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396
           GS++ P +   RP        QL   A++FI+QYYSSIKR GS+AH +RL+EV  E+  T
Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160

Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456
            TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A  MF YICNH+KYATN
Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220

Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516
           +GNLRSAIT+FPQR  G+ DFR+WNSQL+RYAGY+Q DGS  GDPANV+ TE+CIQ GW 
Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280

Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576
           P  GRFDVLPLLLQA  + PELF +PPELVLEVP+ HP  EWF  LGL+WY LPAVSNML
Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340

Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636
           LEIGGLEF A PFSGWYM TEIG R+ CD  RYNILE+VA  M+LD R TSSLWKD+A V
Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400

Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696
           EIN+AVL+S+Q  KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF
Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460

Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756
           HQEM+NY L+P+F YQPDPW     KGT  T  K     FK++A AVK SA LMG  MAK
Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516

Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816
           RVKATILY +ETG++Q+YA+ L  +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN
Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576

Query: 817 GDPPENGEKFGCALMEMRHPNS 838
           GDPPENGE++G A++     NS
Sbjct: 577 GDPPENGERWGFAMLPRLVSNS 598


>gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]
          Length = 629

 Score =  724 bits (1870), Expect = 0.0
 Identities = 350/548 (63%), Positives = 419/548 (76%), Gaps = 11/548 (2%)

Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337
           P + +  PP+S    P +       P+F +VKNWE   +  DTL  ++  +  CT   C+
Sbjct: 47  PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100

Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396
           GS++ P +   RP        QL   A++FI+QYYSSIKR GS+AH +RL+EV  E+  T
Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160

Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456
            TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A  MF YICNH+KYATN
Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220

Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516
           +GNLRSAIT+FPQR  G+ DFR+WNSQL+RYAGY+Q DGS  GDPANV+ TE+CIQ GW 
Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280

Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576
           P  GRFDVLPLLLQA  + PELF +PPELVLEVP+ HP  EWF  LGL+WY LPAVSNML
Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340

Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636
           LEIGGLEF A PFSGWYM TEIG R+ CD  RYNILE+VA  M+LD R TSSLWKD+A V
Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400

Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696
           EIN+AVL+S+Q  KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF
Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460

Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756
           HQEM+NY L+P+F YQPDPW     KGT  T  K     FK++A AVK SA LMG  MAK
Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516

Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816
           RVKATILY +ETG++Q+YA+ L  +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN
Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576

Query: 817 GDPPENGE 824
           GDPPENGE
Sbjct: 577 GDPPENGE 584


>gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]
          Length = 596

 Score =  724 bits (1870), Expect = 0.0
 Identities = 350/548 (63%), Positives = 419/548 (76%), Gaps = 11/548 (2%)

Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337
           P + +  PP+S    P +       P+F +VKNWE   +  DTL  ++  +  CT   C+
Sbjct: 47  PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100

Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396
           GS++ P +   RP        QL   A++FI+QYYSSIKR GS+AH +RL+EV  E+  T
Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160

Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456
            TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A  MF YICNH+KYATN
Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220

Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516
           +GNLRSAIT+FPQR  G+ DFR+WNSQL+RYAGY+Q DGS  GDPANV+ TE+CIQ GW 
Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280

Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576
           P  GRFDVLPLLLQA  + PELF +PPELVLEVP+ HP  EWF  LGL+WY LPAVSNML
Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340

Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636
           LEIGGLEF A PFSGWYM TEIG R+ CD  RYNILE+VA  M+LD R TSSLWKD+A V
Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400

Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696
           EIN+AVL+S+Q  KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF
Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460

Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756
           HQEM+NY L+P+F YQPDPW     KGT  T  K     FK++A AVK SA LMG  MAK
Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516

Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816
           RVKATILY +ETG++Q+YA+ L  +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN
Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576

Query: 817 GDPPENGE 824
           GDPPENGE
Sbjct: 577 GDPPENGE 584


>gi|127139033 cytochrome P450 reductase [Homo sapiens]
          Length = 680

 Score =  246 bits (629), Expect = 9e-65
 Identities = 195/675 (28%), Positives = 309/675 (45%), Gaps = 116/675 (17%)

Query: 762  ILYATETGKSQAYAKTLCEIFKHAFDAKVMSM--EEYDIVHLEH-----ETLVLVVTSTF 814
            + Y ++TG ++ +A  L +   H +  + MS   EEYD+  L         LV+   +T+
Sbjct: 85   VFYGSQTGTAEEFANRLSKD-AHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATY 143

Query: 815  GNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFE 874
            G GDP +N + F                             Y   Q++  D         
Sbjct: 144  GEGDPTDNAQDF-----------------------------YDWLQETDVD--------- 165

Query: 875  SAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRT 934
                L+ V+F+VFGLG++ Y HF A G  VD  LE+LG +RI ++  GD+    EE F T
Sbjct: 166  ----LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFIT 221

Query: 935  WAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHK 994
            W ++ + A C+ F V                + S ++ +  +    +A ++  G      
Sbjct: 222  WREQFWPAVCEHFGV-----------EATGEESSIRQYELVVHTDIDAAKVYMG------ 264

Query: 995  KRVSAARLLSRQNLQSPKSSRSTIFVRLHTN------------------GSQELQYQPGD 1036
                  RL S +N + P  +++     + TN                     +++Y+ GD
Sbjct: 265  ---EMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGD 321

Query: 1037 HLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIF 1096
            H+ V+P N   LVN L + L     ++ ++ +  L+E +                P +  
Sbjct: 322  HVAVYPANDSALVNQLGKIL--GADLDVVMSLNNLDEESNKKHPFPC--------PTSYR 371

Query: 1097 QAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLS----KGLQEYEEWKWGKNPTIV 1152
             A  YYLDIT PP    L + A  A+   E++ L  ++    +G + Y  W       I+
Sbjct: 372  TALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHIL 431

Query: 1153 EVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIH 1212
             +L++ PS++ P   L   L  LQ RYYSI+SS  ++P+ VH+   +V Y T+ G   I+
Sbjct: 432  AILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGR--IN 489

Query: 1213 HGVCSSWLNRIQ------ADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQ 1266
             GV ++WL   +         LVP FVR +  F LP     P I+VGPGTG+APF  F Q
Sbjct: 490  KGVATNWLRAKEPAGENGGRALVPMFVRKS-QFRLPFKATTPVIMVGPGTGVAPFIGFIQ 548

Query: 1267 QRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKK 1326
            +R + ++ +G      +L +GCR+S  D++YREE  Q    G   +L  A+SRE    K 
Sbjct: 549  ERAW-LRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSRE-QSHKV 606

Query: 1327 YVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVF 1385
            YVQ +L++   E +++ L E G HIYVCGD   MA DV      I+ + G +    A  +
Sbjct: 607  YVQHLLKQD-REHLWK-LIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDY 664

Query: 1386 ISRMRDDNRYHEDIF 1400
            I ++    RY  D++
Sbjct: 665  IKKLMTKGRYSLDVW 679


>gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]
          Length = 698

 Score =  218 bits (556), Expect = 3e-56
 Identities = 199/740 (26%), Positives = 313/740 (42%), Gaps = 149/740 (20%)

Query: 762  ILYATETGKSQAYAKTLCE-IFKHAFDAKVMSMEEYDIVHLEHETLVLVVT-STFGNGDP 819
            +LYAT+ G+++A A+ +CE    H F A +  + E D   L+ ET  LVV  ST G GDP
Sbjct: 6    LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 65

Query: 820  PENGEKFGCALMEMRHPNSVQE-ERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGP 878
            P+   KF            V+E + ++  V F                            
Sbjct: 66   PDTARKF------------VKEIQNQTLPVDF---------------------------- 85

Query: 879  LANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWA-- 936
             A++R+ + GLG   Y +FC  G  +D  L+ELG          D+  G E     W   
Sbjct: 86   FAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAG 145

Query: 937  -----KKVFKAA------------------------CDVFCVGDDVNIEKANNSLISNDR 967
                 +K F+++                         ++  +   V + + ++S   +  
Sbjct: 146  LWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSE 205

Query: 968  SWKRNK------------FRLTFVAEAPELTQGLSNV-----HKKRVSAARLLSRQNLQS 1010
              K+N             F  +     P L+Q   N+        +V     L ++  Q 
Sbjct: 206  VLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQV 265

Query: 1011 PKSSRSTIF-------VRLHTN-------------GSQELQYQPGDHLGVFPGNHEDLVN 1050
              +S   +F       V+L TN              + +  YQPGD   V   N +  V 
Sbjct: 266  SVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQ 325

Query: 1051 ALIERL--EDAPPVNQMVKVELLEERNTALGVISNWTDELRLPP-CTIFQAFKYYLDITT 1107
            +L++RL  ED      ++K++   ++  A       T    +P  C++   F + L+I  
Sbjct: 326  SLLQRLQLEDKREHCVLLKIKADTKKKGA-------TLPQHIPAGCSLQFIFTWCLEIRA 378

Query: 1108 PPTPLQLQQFASLATSEKEKQRL--LVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPA 1165
             P    L+      +   EK+RL  L   +G  +Y  +       ++++L  FPS Q P 
Sbjct: 379  IPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPL 438

Query: 1166 TLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQA 1225
            +LLL  L  LQPR YS +SS   +P ++H    IV + +      +  GVC+ WL  + A
Sbjct: 439  SLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVA 498

Query: 1226 DELVP------------------CFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQ 1267
              L P                     R   SFHLP +P +P I+VGPGTGIAPF  F Q 
Sbjct: 499  SVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQH 558

Query: 1268 RQ-FDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSR-----EP 1321
            R+    QH   N   M L FGCR    D+++R+E       G+   L  ++SR     E 
Sbjct: 559  REKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEE 618

Query: 1322 DKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAE 1380
            + P KYVQD +Q    + V R L ++ GHIYVCGD   MA DV  A+ +I++++  +   
Sbjct: 619  EAPAKYVQDNIQLH-GQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKL 677

Query: 1381 DAGVFISRMRDDNRYHEDIF 1400
            +A   ++ ++++ RY +DI+
Sbjct: 678  EAMKTLATLKEEKRYLQDIW 697


>gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]
          Length = 725

 Score =  218 bits (556), Expect = 3e-56
 Identities = 199/740 (26%), Positives = 313/740 (42%), Gaps = 149/740 (20%)

Query: 762  ILYATETGKSQAYAKTLCE-IFKHAFDAKVMSMEEYDIVHLEHETLVLVVT-STFGNGDP 819
            +LYAT+ G+++A A+ +CE    H F A +  + E D   L+ ET  LVV  ST G GDP
Sbjct: 33   LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 92

Query: 820  PENGEKFGCALMEMRHPNSVQE-ERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGP 878
            P+   KF            V+E + ++  V F                            
Sbjct: 93   PDTARKF------------VKEIQNQTLPVDF---------------------------- 112

Query: 879  LANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWA-- 936
             A++R+ + GLG   Y +FC  G  +D  L+ELG          D+  G E     W   
Sbjct: 113  FAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAG 172

Query: 937  -----KKVFKAA------------------------CDVFCVGDDVNIEKANNSLISNDR 967
                 +K F+++                         ++  +   V + + ++S   +  
Sbjct: 173  LWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSE 232

Query: 968  SWKRNK------------FRLTFVAEAPELTQGLSNV-----HKKRVSAARLLSRQNLQS 1010
              K+N             F  +     P L+Q   N+        +V     L ++  Q 
Sbjct: 233  VLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQV 292

Query: 1011 PKSSRSTIF-------VRLHTN-------------GSQELQYQPGDHLGVFPGNHEDLVN 1050
              +S   +F       V+L TN              + +  YQPGD   V   N +  V 
Sbjct: 293  SVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQ 352

Query: 1051 ALIERL--EDAPPVNQMVKVELLEERNTALGVISNWTDELRLPP-CTIFQAFKYYLDITT 1107
            +L++RL  ED      ++K++   ++  A       T    +P  C++   F + L+I  
Sbjct: 353  SLLQRLQLEDKREHCVLLKIKADTKKKGA-------TLPQHIPAGCSLQFIFTWCLEIRA 405

Query: 1108 PPTPLQLQQFASLATSEKEKQRL--LVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPA 1165
             P    L+      +   EK+RL  L   +G  +Y  +       ++++L  FPS Q P 
Sbjct: 406  IPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPL 465

Query: 1166 TLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQA 1225
            +LLL  L  LQPR YS +SS   +P ++H    IV + +      +  GVC+ WL  + A
Sbjct: 466  SLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVA 525

Query: 1226 DELVP------------------CFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQ 1267
              L P                     R   SFHLP +P +P I+VGPGTGIAPF  F Q 
Sbjct: 526  SVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQH 585

Query: 1268 RQ-FDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSR-----EP 1321
            R+    QH   N   M L FGCR    D+++R+E       G+   L  ++SR     E 
Sbjct: 586  REKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEE 645

Query: 1322 DKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAE 1380
            + P KYVQD +Q    + V R L ++ GHIYVCGD   MA DV  A+ +I++++  +   
Sbjct: 646  EAPAKYVQDNIQLH-GQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKL 704

Query: 1381 DAGVFISRMRDDNRYHEDIF 1400
            +A   ++ ++++ RY +DI+
Sbjct: 705  EAMKTLATLKEEKRYLQDIW 724


>gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [Homo
            sapiens]
          Length = 597

 Score =  192 bits (487), Expect = 3e-48
 Identities = 178/658 (27%), Positives = 293/658 (44%), Gaps = 92/658 (13%)

Query: 762  ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820
            +L+ ++TG +Q  ++ L  E  +     +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 8    VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67

Query: 821  ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880
            +N + F   +     P++                                        L 
Sbjct: 68   DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88

Query: 881  NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938
             + F+V GLG  +Y  F      +   L +LGG  +L +  GD+    G + A   W + 
Sbjct: 89   QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148

Query: 939  VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993
            ++     ++     +        L S        KF L F+ EAP   ++G    H    
Sbjct: 149  LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200

Query: 994  ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049
                + +   A ++S Q +  P   +    +     GS  + +  GD + + P N    V
Sbjct: 201  EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259

Query: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108
                + L   P      ++ +L+ R   +      +   RLP PC++     +YLDI + 
Sbjct: 260  QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308

Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164
            P     +  A L+  E E+++LL  S    + E +++   P  TI+EVL +FP  +  +P
Sbjct: 309  PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368

Query: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223
               LL  + +++PR +SI+SS   +P  + + VA+V ++TR  E     G+CSSWL  + 
Sbjct: 369  PDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLD 426

Query: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281
              Q    VP +VR   S   P  P  P I+VGPGTG+APFR+  Q+R    Q        
Sbjct: 427  PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 481

Query: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVY 1341
              L FGCR    D  Y E   Q   K     L  A+SRE ++ K YVQ  L+E L   V+
Sbjct: 482  --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQEQ-KVYVQHRLRE-LGSLVW 536

Query: 1342 RALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHED 1398
              L  QG + Y+ G+  +M ADV +A+  I  ++G L + DA  +++R++   R+  +
Sbjct: 537  ELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTE 594


>gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a
            [Homo sapiens]
          Length = 606

 Score =  188 bits (477), Expect = 4e-47
 Identities = 178/666 (26%), Positives = 292/666 (43%), Gaps = 99/666 (14%)

Query: 762  ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820
            +L+ ++TG +Q  ++ L  E  +     +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 8    VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67

Query: 821  ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880
            +N + F   +     P++                                        L 
Sbjct: 68   DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88

Query: 881  NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938
             + F+V GLG  +Y  F      +   L +LGG  +L +  GD+    G + A   W + 
Sbjct: 89   QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148

Query: 939  VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993
            ++     ++     +        L S        KF L F+ EAP   ++G    H    
Sbjct: 149  LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200

Query: 994  ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049
                + +   A ++S Q +  P   +    +     GS  + +  GD + + P N    V
Sbjct: 201  EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259

Query: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108
                + L   P      ++ +L+ R   +      +   RLP PC++     +YLDI + 
Sbjct: 260  QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308

Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164
            P     +  A L+  E E+++LL  S    + E +++   P  TI+EVL +FP  +  +P
Sbjct: 309  PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368

Query: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223
               LL  + +++PR +SI+SS   +P  + + VA+V ++TR  E     G+CSSWL  + 
Sbjct: 369  PDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLD 426

Query: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281
              Q    VP +VR   S   P  P  P I+VGPGTG+APFR+  Q+R    Q        
Sbjct: 427  PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 481

Query: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREP--------DKPKKYVQDILQ 1333
              L FGCR    D  Y E   Q   K     L  A+SRE          + K YVQ  L+
Sbjct: 482  --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLR 538

Query: 1334 EQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDD 1392
            E L   V+  L  QG + Y+ G+  +M ADV +A+  I  ++G L + DA  +++R++  
Sbjct: 539  E-LGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQT 597

Query: 1393 NRYHED 1398
             R+  +
Sbjct: 598  RRFQTE 603


>gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c
            [Homo sapiens]
          Length = 590

 Score =  183 bits (465), Expect = 9e-46
 Identities = 177/658 (26%), Positives = 291/658 (44%), Gaps = 99/658 (15%)

Query: 762  ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820
            +L+ ++TG +Q  ++ L  E  +     +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 8    VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67

Query: 821  ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880
            +N + F   +     P++                                        L 
Sbjct: 68   DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88

Query: 881  NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938
             + F+V GLG  +Y  F      +   L +LGG  +L +  GD+    G + A   W + 
Sbjct: 89   QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148

Query: 939  VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993
            ++     ++     +        L S        KF L F+ EAP   ++G    H    
Sbjct: 149  LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200

Query: 994  ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049
                + +   A ++S Q +  P   +    +     GS  + +  GD + + P N    V
Sbjct: 201  EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259

Query: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108
                + L   P      ++ +L+ R   +      +   RLP PC++     +YLDI + 
Sbjct: 260  QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308

Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164
            P     +  A L+  E E+++LL  S    + E +++   P  TI+EVL +FP  +  +P
Sbjct: 309  PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368

Query: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223
               LL  + +++PR +SI+SS       + + VA+V ++TR  E     G+CSSWL  + 
Sbjct: 369  PDYLLDLIPVIRPRAFSIASS-------LLILVAVVQFQTRLKEP--RRGLCSSWLASLD 419

Query: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281
              Q    VP +VR   S   P  P  P I+VGPGTG+APFR+  Q+R    Q        
Sbjct: 420  PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 474

Query: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVY 1341
              L FGCR    D  Y E   Q   K     L  A+SRE ++ K YVQ  L+E L   V+
Sbjct: 475  --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQEQ-KVYVQHRLRE-LGSLVW 529

Query: 1342 RALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHED 1398
              L  QG + Y+ G+  +M ADV +A+  I  ++G L + DA  +++R++   R+  +
Sbjct: 530  ELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTE 587


>gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d
            [Homo sapiens]
          Length = 521

 Score =  154 bits (388), Expect = 8e-37
 Identities = 160/604 (26%), Positives = 254/604 (42%), Gaps = 121/604 (20%)

Query: 762  ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820
            +L+ ++TG +Q  ++ L  E  +     +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 8    VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67

Query: 821  ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880
            +N + F   +     P++                                        L 
Sbjct: 68   DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88

Query: 881  NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVF 940
             + F+V GLG  +Y  F      +   L +LGG  +L +                     
Sbjct: 89   QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPV--------------------- 127

Query: 941  KAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH------ 993
                   C+GDD +                 +KF L F+ EAP   ++G    H      
Sbjct: 128  -------CLGDDQH------------ELGLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEP 168

Query: 994  --KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNA 1051
              + +   A ++S Q +  P   +    +     GS  + +  GD + + P N    V  
Sbjct: 169  PSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHVQR 227

Query: 1052 LIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTPPT 1110
              + L   P      ++ +L+ R   +      +   RLP PC++     +YLDI + P 
Sbjct: 228  FCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASVPR 276

Query: 1111 PLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMPAT 1166
                +  A L+  E E+++LL  S    + E +++   P  TI+EVL +FP  +  +P  
Sbjct: 277  RSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPD 336

Query: 1167 LLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI--- 1223
             LL  + +++PR +SI+SS   +P  + + VA+V ++TR  E     G+CSSWL  +   
Sbjct: 337  YLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLDPG 394

Query: 1224 QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMV 1283
            Q    VP +VR   S   P  P  P I+VGPGTG+APFR+  Q+R    Q          
Sbjct: 395  QGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF------ 447

Query: 1284 LVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRA 1343
            L FGCR    D  Y E   Q   K     L  A+SRE ++ K YVQ  L+E L   V+  
Sbjct: 448  LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQEQ-KVYVQHRLRE-LGSLVWEL 504

Query: 1344 LKEQ 1347
            L  Q
Sbjct: 505  LDRQ 508


>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
            isoform 4 [Homo sapiens]
          Length = 2490

 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%)

Query: 1    MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53
            ++D+ F  ++   N   V+LFK    GLGF       L+ E+++   V +  L  G  A 
Sbjct: 1493 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1548

Query: 54   QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109
            +SG I  GD+IL VNG  L  LS    +  LRG A E   +L+ R P G    ++T
Sbjct: 1549 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1603



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 21/55 (38%), Positives = 30/55 (54%)

Query: 41   VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
            + +  +I  GAAE  G I  GD +LAVNG  L   ++  A+E LR      H++L
Sbjct: 1400 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1454



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%)

Query: 8    VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63
            V   +  +  V L K    GLGF +   E++ +    + IS +  GG A+  G ++ GD 
Sbjct: 1084 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1143

Query: 64   ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
            +++VN   L  +S+ +A+E+L+    +  +V+
Sbjct: 1144 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175


>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
            isoform 3 [Homo sapiens]
          Length = 2294

 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%)

Query: 1    MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53
            ++D+ F  ++   N   V+LFK    GLGF       L+ E+++   V +  L  G  A 
Sbjct: 1297 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1352

Query: 54   QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109
            +SG I  GD+IL VNG  L  LS    +  LRG A E   +L+ R P G    ++T
Sbjct: 1353 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1407



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 21/55 (38%), Positives = 30/55 (54%)

Query: 41   VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
            + +  +I  GAAE  G I  GD +LAVNG  L   ++  A+E LR      H++L
Sbjct: 1204 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1258



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%)

Query: 8   VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63
           V   +  +  V L K    GLGF +   E++ +    + IS +  GG A+  G ++ GD 
Sbjct: 893 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 952

Query: 64  ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
           +++VN   L  +S+ +A+E+L+    +  +V+
Sbjct: 953 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 984


>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
            isoform 1 [Homo sapiens]
          Length = 2485

 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%)

Query: 1    MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53
            ++D+ F  ++   N   V+LFK    GLGF       L+ E+++   V +  L  G  A 
Sbjct: 1488 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1543

Query: 54   QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109
            +SG I  GD+IL VNG  L  LS    +  LRG A E   +L+ R P G    ++T
Sbjct: 1544 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1598



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 21/55 (38%), Positives = 30/55 (54%)

Query: 41   VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
            + +  +I  GAAE  G I  GD +LAVNG  L   ++  A+E LR      H++L
Sbjct: 1395 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1449



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%)

Query: 8    VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63
            V   +  +  V L K    GLGF +   E++ +    + IS +  GG A+  G ++ GD 
Sbjct: 1084 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1143

Query: 64   ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
            +++VN   L  +S+ +A+E+L+    +  +V+
Sbjct: 1144 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175


>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
            2 [Homo sapiens]
          Length = 2466

 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%)

Query: 1    MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53
            ++D+ F  ++   N   V+LFK    GLGF       L+ E+++   V +  L  G  A 
Sbjct: 1469 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1524

Query: 54   QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109
            +SG I  GD+IL VNG  L  LS    +  LRG A E   +L+ R P G    ++T
Sbjct: 1525 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1579



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 21/55 (38%), Positives = 30/55 (54%)

Query: 41   VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
            + +  +I  GAAE  G I  GD +LAVNG  L   ++  A+E LR      H++L
Sbjct: 1376 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1430



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%)

Query: 8    VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63
            V   +  +  V L K    GLGF +   E++ +    + IS +  GG A+  G ++ GD 
Sbjct: 1065 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1124

Query: 64   ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
            +++VN   L  +S+ +A+E+L+    +  +V+
Sbjct: 1125 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1156


>gi|11321640 basic beta 1 syntrophin [Homo sapiens]
          Length = 538

 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 28/74 (37%), Positives = 49/74 (66%), Gaps = 1/74 (1%)

Query: 18  VRLFKRKVGGLGFLVKE-RVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLS 76
           V++ K+++GGLG  +K  + +K P++IS + +G AA+Q+  +  GD IL+VNG  L D +
Sbjct: 113 VKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDAT 172

Query: 77  YDSALEVLRGIASE 90
           +D A++ L+    E
Sbjct: 173 HDEAVQALKRAGKE 186


>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
          Length = 540

 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 31/79 (39%), Positives = 49/79 (62%), Gaps = 1/79 (1%)

Query: 13  PNVISVRLFKRKVGGLGFLVKE-RVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRP 71
           P V  VR+ K++ GGLG  +K  R ++ P++IS +  G AA+QS  ++ GD IL+VNG  
Sbjct: 111 PPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTD 170

Query: 72  LVDLSYDSALEVLRGIASE 90
           L   ++D A++ L+    E
Sbjct: 171 LRQATHDQAVQALKRAGKE 189


>gi|87196343 PDZ domain containing 2 [Homo sapiens]
          Length = 2839

 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 27/59 (45%), Positives = 43/59 (72%), Gaps = 1/59 (1%)

Query: 40   PVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILR 98
            P++I  + +GGAAEQ+G+I+AGD ILA+NG+PLV L +  A  +++ +  E  V L++R
Sbjct: 2776 PLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSV-PEGPVQLLIR 2833



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 53/213 (24%), Positives = 88/213 (41%), Gaps = 21/213 (9%)

Query: 27  GLGFLVK----ERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALE 82
           GLG  V      + S   ++++ +  GGAA + G +  GD +L +NG  LV LS++ A+ 
Sbjct: 343 GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402

Query: 83  VLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPPAG 142
           +LR  ++   V L++   E     L    T    P    +T  +   +   D   Q   G
Sbjct: 403 ILR--SATGMVQLVVASKENSAEDL-LRLTSKSLPD---LTSSVEDVSSWTDNEDQEADG 456

Query: 143 KEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAPRP-PGQDPAKKATRVS-----L 196
           +E     +G S          D+ Q+      + G    P  G +  K  +R+S     L
Sbjct: 457 EED----EGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRL 512

Query: 197 QGRGENNELL-KEIEPVLSLLTSGSRGVKGGAP 228
           +   E NEL+ +  +P + +L     G K   P
Sbjct: 513 ESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLP 545



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 28/91 (30%), Positives = 51/91 (56%), Gaps = 5/91 (5%)

Query: 11  IQPNVISV-RLFKRKVGGLGFLV---KERV-SKPPVIISDLIRGGAAEQSGLIQAGDIIL 65
           I+P+VIS+  L+K K  GLGF +   ++ +  +  + +  +   G+A + G ++ GD IL
Sbjct: 579 IRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEIL 638

Query: 66  AVNGRPLVDLSYDSALEVLRGIASETHVVLI 96
            VNG P+  L++  A+   + I S   V+ +
Sbjct: 639 DVNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 2/89 (2%)

Query: 12   QPNVISVRLFKRKVGGLGFLVKERVSKPP--VIISDLIRGGAAEQSGLIQAGDIILAVNG 69
            + +V  + L +++  GLGF V       P  + +  +   GAA Q G +  GD +L+VNG
Sbjct: 2617 EEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNG 2676

Query: 70   RPLVDLSYDSALEVLRGIASETHVVLILR 98
              L  L++ + L+VL         +++++
Sbjct: 2677 ASLAGLAHGNVLKVLHQAQLHKDALVVIK 2705


>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
          Length = 505

 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 40/124 (32%), Positives = 66/124 (53%), Gaps = 10/124 (8%)

Query: 11  IQPNVISVRLFKRKVGGLGFLVKE-RVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69
           +Q   ++VR  K   GGLG  +K  R +K P++IS + +G AA+Q+  +  GD IL+VNG
Sbjct: 83  LQRRRVTVR--KADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNG 140

Query: 70  RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTG-----DGTPKTIRVTQ 124
             L   ++D A++VL+    E  VVL ++  +  + + + +  G     D  P +    Q
Sbjct: 141 EDLSSATHDEAVQVLKKTGKE--VVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQ 198

Query: 125 PLGP 128
           P  P
Sbjct: 199 PSSP 202


>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
            homolog, Drosophila); translocated to, 4 isoform 1 [Homo
            sapiens]
          Length = 1834

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 15/212 (7%)

Query: 12   QPNVISVRLFKRKVGGLGFLVKERVS--KPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69
            +P +I+V L K+   GL  +  +     K  + +  +++GGAA+  G + AGD +L+V+G
Sbjct: 1003 EPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDG 1062

Query: 70   RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLG-- 127
            R LV LS + A E++   +S   VV +    +G   H   T     +P   R++   G  
Sbjct: 1063 RSLVGLSQERAAELMTRTSS---VVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSG 1119

Query: 128  ---PPTKAVDL-----SHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLA 179
               P ++  +L      +  P   + P A         G      +  +  S P+     
Sbjct: 1120 KPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQP 1179

Query: 180  PRPPGQDPAKKATRVSLQGRGENNELLKEIEP 211
            P P G+      T   +      N   +E  P
Sbjct: 1180 PSPGGKSAYASGTTAKITSVSTGNLCTEEQTP 1211


>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
            homolog, Drosophila); translocated to, 4 isoform 2 [Homo
            sapiens]
          Length = 1651

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 15/212 (7%)

Query: 12   QPNVISVRLFKRKVGGLGFLVKERVS--KPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69
            +P +I+V L K+   GL  +  +     K  + +  +++GGAA+  G + AGD +L+V+G
Sbjct: 1004 EPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDG 1063

Query: 70   RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLG-- 127
            R LV LS + A E++   +S   VV +    +G   H   T     +P   R++   G  
Sbjct: 1064 RSLVGLSQERAAELMTRTSS---VVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSG 1120

Query: 128  ---PPTKAVDL-----SHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLA 179
               P ++  +L      +  P   + P A         G      +  +  S P+     
Sbjct: 1121 KPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQP 1180

Query: 180  PRPPGQDPAKKATRVSLQGRGENNELLKEIEP 211
            P P G+      T   +      N   +E  P
Sbjct: 1181 PSPGGKSAYASGTTAKITSVSTGNLCTEEQTP 1212


>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
            homolog, Drosophila); translocated to, 4 isoform 3 [Homo
            sapiens]
          Length = 1612

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 15/212 (7%)

Query: 12   QPNVISVRLFKRKVGGLGFLVKERVS--KPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69
            +P +I+V L K+   GL  +  +     K  + +  +++GGAA+  G + AGD +L+V+G
Sbjct: 988  EPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDG 1047

Query: 70   RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLG-- 127
            R LV LS + A E++   +S   VV +    +G   H   T     +P   R++   G  
Sbjct: 1048 RSLVGLSQERAAELMTRTSS---VVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSG 1104

Query: 128  ---PPTKAVDL-----SHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLA 179
               P ++  +L      +  P   + P A         G      +  +  S P+     
Sbjct: 1105 KPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQP 1164

Query: 180  PRPPGQDPAKKATRVSLQGRGENNELLKEIEP 211
            P P G+      T   +      N   +E  P
Sbjct: 1165 PSPGGKSAYASGTTAKITSVSTGNLCTEEQTP 1196


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 28/136 (20%)

Query: 11  IQPNVISVRLFKRKVGGLGFLVKERVSKP------PVIISDLIRGGAAEQSGLIQAGDII 64
           I   V+ ++LFK   G LGF +   V          + ++ +I GGAA++ G +Q GD +
Sbjct: 136 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 194

Query: 65  LAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQ 124
           L VN   L +++++ A+ +L+  +                   E  +   G P TI +T 
Sbjct: 195 LMVNNYSLEEVTHEEAVAILKNTS-------------------EVVYLKVGKPTTIYMTD 235

Query: 125 PLGPPTKAVDLSHQPP 140
           P GPP   +  S+ PP
Sbjct: 236 PYGPPD--ITHSYSPP 249



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 1/77 (1%)

Query: 27  GLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRG 86
           GLGF +        + +S ++ GG A+ SG +Q GD IL+VNG  L   S++ A   L+G
Sbjct: 327 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 386

Query: 87  IASETHVVLILRGPEGF 103
            A +T  ++    PE +
Sbjct: 387 -AGQTVTIIAQYQPEDY 402


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 28/136 (20%)

Query: 11  IQPNVISVRLFKRKVGGLGFLVKERVSKP------PVIISDLIRGGAAEQSGLIQAGDII 64
           I   V+ ++LFK   G LGF +   V          + ++ +I GGAA++ G +Q GD +
Sbjct: 292 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 350

Query: 65  LAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQ 124
           L VN   L +++++ A+ +L+  +                   E  +   G P TI +T 
Sbjct: 351 LMVNNYSLEEVTHEEAVAILKNTS-------------------EVVYLKVGKPTTIYMTD 391

Query: 125 PLGPPTKAVDLSHQPP 140
           P GPP   +  S+ PP
Sbjct: 392 PYGPPD--ITHSYSPP 405



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 1/77 (1%)

Query: 27  GLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRG 86
           GLGF +        + +S ++ GG A+ SG +Q GD IL+VNG  L   S++ A   L+G
Sbjct: 535 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 594

Query: 87  IASETHVVLILRGPEGF 103
            A +T  ++    PE +
Sbjct: 595 -AGQTVTIIAQYQPEDY 610


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 28/136 (20%)

Query: 11  IQPNVISVRLFKRKVGGLGFLVKERVSKP------PVIISDLIRGGAAEQSGLIQAGDII 64
           I   V+ ++LFK   G LGF +   V          + ++ +I GGAA++ G +Q GD +
Sbjct: 187 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 245

Query: 65  LAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQ 124
           L VN   L +++++ A+ +L+  +                   E  +   G P TI +T 
Sbjct: 246 LMVNNYSLEEVTHEEAVAILKNTS-------------------EVVYLKVGKPTTIYMTD 286

Query: 125 PLGPPTKAVDLSHQPP 140
           P GPP   +  S+ PP
Sbjct: 287 PYGPPD--ITHSYSPP 300



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 1/77 (1%)

Query: 27  GLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRG 86
           GLGF +        + +S ++ GG A+ SG +Q GD IL+VNG  L   S++ A   L+G
Sbjct: 430 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 489

Query: 87  IASETHVVLILRGPEGF 103
            A +T  ++    PE +
Sbjct: 490 -AGQTVTIIAQYQPEDY 505


>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
            sapiens]
          Length = 1287

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 40/97 (41%), Positives = 50/97 (51%), Gaps = 14/97 (14%)

Query: 22   KRKVGGLGF----LVKERVSKPPVIISDLIR------GGAAEQSGLIQAGDIILAVNGRP 71
            K+   GLGF    + KE  S    + SDL+R      G  AE++G I AGDIILAVNGR 
Sbjct: 1061 KKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1117

Query: 72   LVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLE 108
               L +   L +LRG   E   +L+ R P G    LE
Sbjct: 1118 TEGLIFQEVLHLLRGAPQEV-TLLLCRPPPGALPELE 1153



 Score = 38.1 bits (87), Expect = 0.061
 Identities = 26/92 (28%), Positives = 49/92 (53%), Gaps = 6/92 (6%)

Query: 15  VISVRLFKRKVGGLGFLVKERV----SKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGR 70
           ++ V L +    G GF++ E      + P + IS +I GG AE++  I+ G  ILA+N  
Sbjct: 751 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810

Query: 71  PLVDLSYDSALEVLRGIASETHVVLILRGPEG 102
            L   +++ A+ +++   S  ++ LI+   +G
Sbjct: 811 SLEGFTFNMAVRMIQN--SPDNIELIISQSKG 840



 Score = 36.6 bits (83), Expect = 0.18
 Identities = 32/119 (26%), Positives = 50/119 (42%), Gaps = 5/119 (4%)

Query: 26   GGLGFLVKERVSKPP----VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSAL 81
            G LGF V   ++       + +  ++ GG A + G I  GD +L V+G  L  L++  A+
Sbjct: 936  GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 995

Query: 82   EVLRGIASETHVVLILRGPEGFTTHLETTFT-GDGTPKTIRVTQPLGPPTKAVDLSHQP 139
            + L G      +VL  R P           + GD       VT   G P+  V ++  P
Sbjct: 996  QCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGP 1054


>gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo
           sapiens]
          Length = 320

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 40/97 (41%), Positives = 50/97 (51%), Gaps = 14/97 (14%)

Query: 22  KRKVGGLGF----LVKERVSKPPVIISDLIR------GGAAEQSGLIQAGDIILAVNGRP 71
           K+   GLGF    + KE  S    + SDL+R      G  AE++G I AGDIILAVNGR 
Sbjct: 94  KKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150

Query: 72  LVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLE 108
              L +   L +LRG   E   +L+ R P G    LE
Sbjct: 151 TEGLIFQEVLHLLRGAPQEV-TLLLCRPPPGALPELE 186


>gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo
           sapiens]
          Length = 261

 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 40/97 (41%), Positives = 50/97 (51%), Gaps = 14/97 (14%)

Query: 22  KRKVGGLGF----LVKERVSKPPVIISDLIR------GGAAEQSGLIQAGDIILAVNGRP 71
           K+   GLGF    + KE  S    + SDL+R      G  AE++G I AGDIILAVNGR 
Sbjct: 35  KKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91

Query: 72  LVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLE 108
              L +   L +LRG   E   +L+ R P G    LE
Sbjct: 92  TEGLIFQEVLHLLRGAPQEV-TLLLCRPPPGALPELE 127


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,681,480
Number of Sequences: 37866
Number of extensions: 2987021
Number of successful extensions: 8460
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 7966
Number of HSP's gapped (non-prelim): 504
length of query: 1434
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1319
effective length of database: 13,892,928
effective search space: 18324772032
effective search space used: 18324772032
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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