BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens] (1434 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens] 2928 0.0 gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens] 1392 0.0 gi|24041029 nitric oxide synthase 2A [Homo sapiens] 1232 0.0 gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens] 731 0.0 gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens] 724 0.0 gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens] 724 0.0 gi|127139033 cytochrome P450 reductase [Homo sapiens] 246 9e-65 gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens] 218 3e-56 gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens] 218 3e-56 gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [... 192 3e-48 gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a... 188 4e-47 gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c... 183 9e-46 gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d... 154 8e-37 gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 58 6e-08 gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 58 6e-08 gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 58 6e-08 gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 58 6e-08 gi|11321640 basic beta 1 syntrophin [Homo sapiens] 57 1e-07 gi|5803177 basic beta 2 syntrophin [Homo sapiens] 57 1e-07 gi|87196343 PDZ domain containing 2 [Homo sapiens] 56 3e-07 gi|4507137 acidic alpha 1 syntrophin [Homo sapiens] 55 5e-07 gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 54 1e-06 gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora... 54 1e-06 gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora... 54 1e-06 gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 54 1e-06 gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 54 1e-06 gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 54 1e-06 gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 54 1e-06 gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo sa... 54 1e-06 gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo sap... 54 1e-06 >gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens] Length = 1434 Score = 2928 bits (7590), Expect = 0.0 Identities = 1434/1434 (100%), Positives = 1434/1434 (100%) Query: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA 60 MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA Sbjct: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA 60 Query: 61 GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI 120 GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI Sbjct: 61 GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI 120 Query: 121 RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP 180 RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP Sbjct: 121 RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP 180 Query: 181 RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV 240 RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV Sbjct: 181 RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV 240 Query: 241 DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS 300 DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS Sbjct: 241 DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS 300 Query: 301 KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF 360 KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF Sbjct: 301 KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF 360 Query: 361 PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC 420 PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC Sbjct: 361 PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC 420 Query: 421 VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW 480 VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW Sbjct: 421 VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW 480 Query: 481 NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ 540 NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ Sbjct: 481 NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ 540 Query: 541 IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV 600 IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV Sbjct: 541 IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV 600 Query: 601 RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT 660 RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT Sbjct: 601 RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT 660 Query: 661 ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV 720 ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV Sbjct: 661 ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV 720 Query: 721 WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE 780 WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE Sbjct: 721 WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE 780 Query: 781 IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ 840 IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ Sbjct: 781 IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ 840 Query: 841 EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF 900 EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF Sbjct: 841 EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF 900 Query: 901 GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN 960 GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN Sbjct: 901 GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN 960 Query: 961 SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV 1020 SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV Sbjct: 961 SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV 1020 Query: 1021 RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV 1080 RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV Sbjct: 1021 RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV 1080 Query: 1081 ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY 1140 ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY Sbjct: 1081 ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY 1140 Query: 1141 EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV 1200 EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV Sbjct: 1141 EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV 1200 Query: 1201 SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP 1260 SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP Sbjct: 1201 SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP 1260 Query: 1261 FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE 1320 FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE Sbjct: 1261 FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE 1320 Query: 1321 PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE 1380 PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE Sbjct: 1321 PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE 1380 Query: 1381 DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS 1434 DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS Sbjct: 1381 DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS 1434 >gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens] Length = 1203 Score = 1392 bits (3603), Expect = 0.0 Identities = 678/1149 (59%), Positives = 853/1149 (74%), Gaps = 17/1149 (1%) Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337 P + + PP+S P + P+F +VKNWE + DTL ++ + CT C+ Sbjct: 47 PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100 Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396 GS++ P + RP QL A++FI+QYYSSIKR GS+AH +RL+EV E+ T Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160 Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456 TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A MF YICNH+KYATN Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220 Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516 +GNLRSAIT+FPQR G+ DFR+WNSQL+RYAGY+Q DGS GDPANV+ TE+CIQ GW Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280 Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576 P GRFDVLPLLLQA + PELF +PPELVLEVP+ HP EWF LGL+WY LPAVSNML Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340 Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636 LEIGGLEF A PFSGWYM TEIG R+ CD RYNILE+VA M+LD R TSSLWKD+A V Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400 Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696 EIN+AVL+S+Q KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460 Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756 HQEM+NY L+P+F YQPDPW KGT T K FK++A AVK SA LMG MAK Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516 Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816 RVKATILY +ETG++Q+YA+ L +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576 Query: 817 GDPPENGEKFGCALMEMRHPNSVQ---EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNF 873 GDPPENGE F ALMEM P + E+ KSYK+RFNS+S S N Sbjct: 577 GDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNT 636 Query: 874 ESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFR 933 +SAG L +RF VFGLGSRAYPHFCAF AVDT LEELGGER+L++ +GDELCGQEEAFR Sbjct: 637 DSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFR 696 Query: 934 TWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVH 993 WA+ F+AAC+ FCVG+D + A + S RSWKR ++RL+ AE +L GL +VH Sbjct: 697 GWAQAAFQAACETFCVGEDA--KAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVH 754 Query: 994 KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALI 1053 ++++ A + S +NLQS KS+R+TI VRL T G + LQYQPGDH+GV P N LV AL+ Sbjct: 755 RRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALL 814 Query: 1054 ERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQ 1113 R+ED P + V VE LE+ + G W + RLPPCT+ QA ++LDIT+PP+P Sbjct: 815 SRVEDPPAPTEPVAVEQLEKGSPG-GPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQL 873 Query: 1114 LQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLS 1173 L+ ++LA +E+Q L LS+ + YEEWKW + PT++EVLE+FPS+ +PA LLLTQL Sbjct: 874 LRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLP 933 Query: 1174 LLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADELVPCFV 1233 LLQPRYYS+SS+P +P E+HLTVA+++YRT+DG GP+H+GVCS+WL++++ + VPCF+ Sbjct: 934 LLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFI 993 Query: 1234 RGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKI 1293 RGAPSF LP +P +PCILVGPGTGIAPFR FWQ+R DI+ KG+ P PM LVFGCR S++ Sbjct: 994 RGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFGCRCSQL 1053 Query: 1294 DHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQGGHIYV 1353 DH+YR+E A+ +GVF + TA+SREPD PK YVQDIL+ +LA V+R L + GH++V Sbjct: 1054 DHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERGHMFV 1113 Query: 1354 CGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRL 1413 CGDVTMA +VL+ +QRI+ +G + ++AG I +RD RYHEDIFG+TLRT EVT+R+ Sbjct: 1114 CGDVTMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRI 1173 Query: 1414 RSESIAFIE 1422 R++S + E Sbjct: 1174 RTQSFSLQE 1182 >gi|24041029 nitric oxide synthase 2A [Homo sapiens] Length = 1153 Score = 1232 bits (3187), Expect = 0.0 Identities = 615/1133 (54%), Positives = 779/1133 (68%), Gaps = 58/1133 (5%) Query: 275 LNNPYSEKEQPPT-SGKQSPTK----NGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLET 329 L+ +E QP +GK+SP + +P PR +++KNW + + DTLH K+ Sbjct: 49 LSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGIL 108 Query: 330 GCTEYICMGSIMHPSQHARRPEDVRTK-GQLFPLAKEFIDQYYSSIKRFGSKAHMERLEE 388 C C+GSIM P R P D T +L P A EF++QYY S K + H+ R+E Sbjct: 109 TCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEA 168 Query: 389 VNKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYIC 448 V KEI+TT TYQL ELI+ K AWRNA RC+GRIQWS LQVFDAR C+TA MF +IC Sbjct: 169 VTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHIC 228 Query: 449 NHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTE 508 HV+Y+TN GN+RSAIT+FPQR+DGKHDFRVWN+QLIRYAGY+ PDGS GDPANV+FT+ Sbjct: 229 RHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQ 288 Query: 509 ICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYG 568 +CI GWKP GRFDV+PL+LQANG DPELF+IPP+LVLEV + HPK+EWF++L LKWY Sbjct: 289 LCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYA 348 Query: 569 LPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSS 628 LPAV+NMLLE+GGLEF CPF+GWYMGTEIGVRD+CD RYNILEEV ++M L+ K +S Sbjct: 349 LPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLAS 408 Query: 629 LWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPM 688 LWKDQA+VEINIAVL+SFQ VTI+DHHSA ESF+K+M+NEYR RGGCPADW+W+VPPM Sbjct: 409 LWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPM 468 Query: 689 SGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAK 748 SGSITPVFHQEMLNY L+P + YQ + W THVW+ P KRR I K L +AV F+ Sbjct: 469 SGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRP-KRREIPLKVLVKAVLFACM 527 Query: 749 LMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVL 808 LM + MA RV+ TIL+ATETGKS+A A L +F AF+ KV+ M++Y + LE E L+L Sbjct: 528 LMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLL 587 Query: 809 VVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPD 868 VVTSTFGNGD P NGEK +L ++ N+ Sbjct: 588 VVTSTFGNGDCPGNGEKLKKSLFMLKELNN------------------------------ 617 Query: 869 LRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQ 928 R++VFGLGS YP FCAF H +D L LG ++ M EGDEL GQ Sbjct: 618 ------------KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQ 665 Query: 929 EEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQG 988 E+AFR+WA + FKAAC+ F V +I+ L +++ +W + +RL ++ +L++ Sbjct: 666 EDAFRSWAVQTFKAACETFDVRGKQHIQIP--KLYTSNVTWDPHHYRLVQDSQPLDLSKA 723 Query: 989 LSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDL 1048 LS++H K V RL SRQNLQSP SSR+TI V L Q L Y PG+HLGV PGN L Sbjct: 724 LSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPAL 783 Query: 1049 VNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTP 1108 V ++ER+ D P +Q V++E L+E S W + RLPPC++ QA Y+LDITTP Sbjct: 784 VQGILERVVDGPTPHQTVRLEALDESG------SYWVSDKRLPPCSLSQALTYFLDITTP 837 Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLL 1168 PT L LQ+ A +AT E E+QRL L + EY +WK+ +PT +EVLEEFPS+++ A L Sbjct: 838 PTQLLLQKLAQVATEEPERQRLEALCQP-SEYSKWKFTNSPTFLEVLEEFPSLRVSAGFL 896 Query: 1169 LTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADEL 1228 L+QL +L+PR+YSISSS D P E+HLTVA+V+Y TRDG+GP+HHGVCS+WLN ++ + Sbjct: 897 LSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDP 956 Query: 1229 VPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGC 1288 VPCFVR A FHLP +P PCIL+GPGTGIAPFRSFWQQR D QHKG+ M LVFGC Sbjct: 957 VPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGC 1016 Query: 1289 RQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQG 1348 R+ DHIY+EE L+ KGV ++TAYSR P KPK YVQDIL++QLA V R L ++ Sbjct: 1017 RRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEP 1076 Query: 1349 GHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFG 1401 GH+YVCGDV MA DV +++++ + KL+ E + +++ RYHEDIFG Sbjct: 1077 GHLYVCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFG 1129 >gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens] Length = 614 Score = 731 bits (1887), Expect = 0.0 Identities = 354/562 (62%), Positives = 427/562 (75%), Gaps = 11/562 (1%) Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337 P + + PP+S P + P+F +VKNWE + DTL ++ + CT C+ Sbjct: 47 PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100 Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396 GS++ P + RP QL A++FI+QYYSSIKR GS+AH +RL+EV E+ T Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160 Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456 TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A MF YICNH+KYATN Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220 Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516 +GNLRSAIT+FPQR G+ DFR+WNSQL+RYAGY+Q DGS GDPANV+ TE+CIQ GW Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280 Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576 P GRFDVLPLLLQA + PELF +PPELVLEVP+ HP EWF LGL+WY LPAVSNML Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340 Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636 LEIGGLEF A PFSGWYM TEIG R+ CD RYNILE+VA M+LD R TSSLWKD+A V Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400 Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696 EIN+AVL+S+Q KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460 Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756 HQEM+NY L+P+F YQPDPW KGT T K FK++A AVK SA LMG MAK Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516 Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816 RVKATILY +ETG++Q+YA+ L +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576 Query: 817 GDPPENGEKFGCALMEMRHPNS 838 GDPPENGE++G A++ NS Sbjct: 577 GDPPENGERWGFAMLPRLVSNS 598 >gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens] Length = 629 Score = 724 bits (1870), Expect = 0.0 Identities = 350/548 (63%), Positives = 419/548 (76%), Gaps = 11/548 (2%) Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337 P + + PP+S P + P+F +VKNWE + DTL ++ + CT C+ Sbjct: 47 PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100 Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396 GS++ P + RP QL A++FI+QYYSSIKR GS+AH +RL+EV E+ T Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160 Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456 TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A MF YICNH+KYATN Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220 Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516 +GNLRSAIT+FPQR G+ DFR+WNSQL+RYAGY+Q DGS GDPANV+ TE+CIQ GW Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280 Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576 P GRFDVLPLLLQA + PELF +PPELVLEVP+ HP EWF LGL+WY LPAVSNML Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340 Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636 LEIGGLEF A PFSGWYM TEIG R+ CD RYNILE+VA M+LD R TSSLWKD+A V Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400 Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696 EIN+AVL+S+Q KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460 Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756 HQEM+NY L+P+F YQPDPW KGT T K FK++A AVK SA LMG MAK Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516 Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816 RVKATILY +ETG++Q+YA+ L +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576 Query: 817 GDPPENGE 824 GDPPENGE Sbjct: 577 GDPPENGE 584 >gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens] Length = 596 Score = 724 bits (1870), Expect = 0.0 Identities = 350/548 (63%), Positives = 419/548 (76%), Gaps = 11/548 (2%) Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337 P + + PP+S P + P+F +VKNWE + DTL ++ + CT C+ Sbjct: 47 PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100 Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396 GS++ P + RP QL A++FI+QYYSSIKR GS+AH +RL+EV E+ T Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160 Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456 TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A MF YICNH+KYATN Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220 Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516 +GNLRSAIT+FPQR G+ DFR+WNSQL+RYAGY+Q DGS GDPANV+ TE+CIQ GW Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280 Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576 P GRFDVLPLLLQA + PELF +PPELVLEVP+ HP EWF LGL+WY LPAVSNML Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340 Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636 LEIGGLEF A PFSGWYM TEIG R+ CD RYNILE+VA M+LD R TSSLWKD+A V Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400 Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696 EIN+AVL+S+Q KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460 Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756 HQEM+NY L+P+F YQPDPW KGT T K FK++A AVK SA LMG MAK Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516 Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816 RVKATILY +ETG++Q+YA+ L +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576 Query: 817 GDPPENGE 824 GDPPENGE Sbjct: 577 GDPPENGE 584 >gi|127139033 cytochrome P450 reductase [Homo sapiens] Length = 680 Score = 246 bits (629), Expect = 9e-65 Identities = 195/675 (28%), Positives = 309/675 (45%), Gaps = 116/675 (17%) Query: 762 ILYATETGKSQAYAKTLCEIFKHAFDAKVMSM--EEYDIVHLEH-----ETLVLVVTSTF 814 + Y ++TG ++ +A L + H + + MS EEYD+ L LV+ +T+ Sbjct: 85 VFYGSQTGTAEEFANRLSKD-AHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATY 143 Query: 815 GNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFE 874 G GDP +N + F Y Q++ D Sbjct: 144 GEGDPTDNAQDF-----------------------------YDWLQETDVD--------- 165 Query: 875 SAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRT 934 L+ V+F+VFGLG++ Y HF A G VD LE+LG +RI ++ GD+ EE F T Sbjct: 166 ----LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFIT 221 Query: 935 WAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHK 994 W ++ + A C+ F V + S ++ + + +A ++ G Sbjct: 222 WREQFWPAVCEHFGV-----------EATGEESSIRQYELVVHTDIDAAKVYMG------ 264 Query: 995 KRVSAARLLSRQNLQSPKSSRSTIFVRLHTN------------------GSQELQYQPGD 1036 RL S +N + P +++ + TN +++Y+ GD Sbjct: 265 ---EMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGD 321 Query: 1037 HLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIF 1096 H+ V+P N LVN L + L ++ ++ + L+E + P + Sbjct: 322 HVAVYPANDSALVNQLGKIL--GADLDVVMSLNNLDEESNKKHPFPC--------PTSYR 371 Query: 1097 QAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLS----KGLQEYEEWKWGKNPTIV 1152 A YYLDIT PP L + A A+ E++ L ++ +G + Y W I+ Sbjct: 372 TALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHIL 431 Query: 1153 EVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIH 1212 +L++ PS++ P L L LQ RYYSI+SS ++P+ VH+ +V Y T+ G I+ Sbjct: 432 AILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGR--IN 489 Query: 1213 HGVCSSWLNRIQ------ADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQ 1266 GV ++WL + LVP FVR + F LP P I+VGPGTG+APF F Q Sbjct: 490 KGVATNWLRAKEPAGENGGRALVPMFVRKS-QFRLPFKATTPVIMVGPGTGVAPFIGFIQ 548 Query: 1267 QRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKK 1326 +R + ++ +G +L +GCR+S D++YREE Q G +L A+SRE K Sbjct: 549 ERAW-LRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSRE-QSHKV 606 Query: 1327 YVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVF 1385 YVQ +L++ E +++ L E G HIYVCGD MA DV I+ + G + A + Sbjct: 607 YVQHLLKQD-REHLWK-LIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDY 664 Query: 1386 ISRMRDDNRYHEDIF 1400 I ++ RY D++ Sbjct: 665 IKKLMTKGRYSLDVW 679 >gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens] Length = 698 Score = 218 bits (556), Expect = 3e-56 Identities = 199/740 (26%), Positives = 313/740 (42%), Gaps = 149/740 (20%) Query: 762 ILYATETGKSQAYAKTLCE-IFKHAFDAKVMSMEEYDIVHLEHETLVLVVT-STFGNGDP 819 +LYAT+ G+++A A+ +CE H F A + + E D L+ ET LVV ST G GDP Sbjct: 6 LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 65 Query: 820 PENGEKFGCALMEMRHPNSVQE-ERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGP 878 P+ KF V+E + ++ V F Sbjct: 66 PDTARKF------------VKEIQNQTLPVDF---------------------------- 85 Query: 879 LANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWA-- 936 A++R+ + GLG Y +FC G +D L+ELG D+ G E W Sbjct: 86 FAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAG 145 Query: 937 -----KKVFKAA------------------------CDVFCVGDDVNIEKANNSLISNDR 967 +K F+++ ++ + V + + ++S + Sbjct: 146 LWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSE 205 Query: 968 SWKRNK------------FRLTFVAEAPELTQGLSNV-----HKKRVSAARLLSRQNLQS 1010 K+N F + P L+Q N+ +V L ++ Q Sbjct: 206 VLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQV 265 Query: 1011 PKSSRSTIF-------VRLHTN-------------GSQELQYQPGDHLGVFPGNHEDLVN 1050 +S +F V+L TN + + YQPGD V N + V Sbjct: 266 SVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQ 325 Query: 1051 ALIERL--EDAPPVNQMVKVELLEERNTALGVISNWTDELRLPP-CTIFQAFKYYLDITT 1107 +L++RL ED ++K++ ++ A T +P C++ F + L+I Sbjct: 326 SLLQRLQLEDKREHCVLLKIKADTKKKGA-------TLPQHIPAGCSLQFIFTWCLEIRA 378 Query: 1108 PPTPLQLQQFASLATSEKEKQRL--LVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPA 1165 P L+ + EK+RL L +G +Y + ++++L FPS Q P Sbjct: 379 IPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPL 438 Query: 1166 TLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQA 1225 +LLL L LQPR YS +SS +P ++H IV + + + GVC+ WL + A Sbjct: 439 SLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVA 498 Query: 1226 DELVP------------------CFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQ 1267 L P R SFHLP +P +P I+VGPGTGIAPF F Q Sbjct: 499 SVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQH 558 Query: 1268 RQ-FDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSR-----EP 1321 R+ QH N M L FGCR D+++R+E G+ L ++SR E Sbjct: 559 REKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEE 618 Query: 1322 DKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAE 1380 + P KYVQD +Q + V R L ++ GHIYVCGD MA DV A+ +I++++ + Sbjct: 619 EAPAKYVQDNIQLH-GQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKL 677 Query: 1381 DAGVFISRMRDDNRYHEDIF 1400 +A ++ ++++ RY +DI+ Sbjct: 678 EAMKTLATLKEEKRYLQDIW 697 >gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens] Length = 725 Score = 218 bits (556), Expect = 3e-56 Identities = 199/740 (26%), Positives = 313/740 (42%), Gaps = 149/740 (20%) Query: 762 ILYATETGKSQAYAKTLCE-IFKHAFDAKVMSMEEYDIVHLEHETLVLVVT-STFGNGDP 819 +LYAT+ G+++A A+ +CE H F A + + E D L+ ET LVV ST G GDP Sbjct: 33 LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 92 Query: 820 PENGEKFGCALMEMRHPNSVQE-ERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGP 878 P+ KF V+E + ++ V F Sbjct: 93 PDTARKF------------VKEIQNQTLPVDF---------------------------- 112 Query: 879 LANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWA-- 936 A++R+ + GLG Y +FC G +D L+ELG D+ G E W Sbjct: 113 FAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAG 172 Query: 937 -----KKVFKAA------------------------CDVFCVGDDVNIEKANNSLISNDR 967 +K F+++ ++ + V + + ++S + Sbjct: 173 LWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSE 232 Query: 968 SWKRNK------------FRLTFVAEAPELTQGLSNV-----HKKRVSAARLLSRQNLQS 1010 K+N F + P L+Q N+ +V L ++ Q Sbjct: 233 VLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQV 292 Query: 1011 PKSSRSTIF-------VRLHTN-------------GSQELQYQPGDHLGVFPGNHEDLVN 1050 +S +F V+L TN + + YQPGD V N + V Sbjct: 293 SVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQ 352 Query: 1051 ALIERL--EDAPPVNQMVKVELLEERNTALGVISNWTDELRLPP-CTIFQAFKYYLDITT 1107 +L++RL ED ++K++ ++ A T +P C++ F + L+I Sbjct: 353 SLLQRLQLEDKREHCVLLKIKADTKKKGA-------TLPQHIPAGCSLQFIFTWCLEIRA 405 Query: 1108 PPTPLQLQQFASLATSEKEKQRL--LVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPA 1165 P L+ + EK+RL L +G +Y + ++++L FPS Q P Sbjct: 406 IPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPL 465 Query: 1166 TLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQA 1225 +LLL L LQPR YS +SS +P ++H IV + + + GVC+ WL + A Sbjct: 466 SLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVA 525 Query: 1226 DELVP------------------CFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQ 1267 L P R SFHLP +P +P I+VGPGTGIAPF F Q Sbjct: 526 SVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQH 585 Query: 1268 RQ-FDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSR-----EP 1321 R+ QH N M L FGCR D+++R+E G+ L ++SR E Sbjct: 586 REKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEE 645 Query: 1322 DKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAE 1380 + P KYVQD +Q + V R L ++ GHIYVCGD MA DV A+ +I++++ + Sbjct: 646 EAPAKYVQDNIQLH-GQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKL 704 Query: 1381 DAGVFISRMRDDNRYHEDIF 1400 +A ++ ++++ RY +DI+ Sbjct: 705 EAMKTLATLKEEKRYLQDIW 724 >gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [Homo sapiens] Length = 597 Score = 192 bits (487), Expect = 3e-48 Identities = 178/658 (27%), Positives = 293/658 (44%), Gaps = 92/658 (13%) Query: 762 ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820 +L+ ++TG +Q ++ L E + +V +++ Y +V+L +E LV+ V +T G GDPP Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67 Query: 821 ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880 +N + F + P++ L Sbjct: 68 DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88 Query: 881 NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938 + F+V GLG +Y F + L +LGG +L + GD+ G + A W + Sbjct: 89 QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148 Query: 939 VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993 ++ ++ + L S KF L F+ EAP ++G H Sbjct: 149 LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200 Query: 994 ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049 + + A ++S Q + P + + GS + + GD + + P N V Sbjct: 201 EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259 Query: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108 + L P ++ +L+ R + + RLP PC++ +YLDI + Sbjct: 260 QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308 Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164 P + A L+ E E+++LL S + E +++ P TI+EVL +FP + +P Sbjct: 309 PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368 Query: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223 LL + +++PR +SI+SS +P + + VA+V ++TR E G+CSSWL + Sbjct: 369 PDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLD 426 Query: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281 Q VP +VR S P P P I+VGPGTG+APFR+ Q+R Q Sbjct: 427 PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 481 Query: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVY 1341 L FGCR D Y E Q K L A+SRE ++ K YVQ L+E L V+ Sbjct: 482 --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQEQ-KVYVQHRLRE-LGSLVW 536 Query: 1342 RALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHED 1398 L QG + Y+ G+ +M ADV +A+ I ++G L + DA +++R++ R+ + Sbjct: 537 ELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTE 594 >gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a [Homo sapiens] Length = 606 Score = 188 bits (477), Expect = 4e-47 Identities = 178/666 (26%), Positives = 292/666 (43%), Gaps = 99/666 (14%) Query: 762 ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820 +L+ ++TG +Q ++ L E + +V +++ Y +V+L +E LV+ V +T G GDPP Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67 Query: 821 ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880 +N + F + P++ L Sbjct: 68 DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88 Query: 881 NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938 + F+V GLG +Y F + L +LGG +L + GD+ G + A W + Sbjct: 89 QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148 Query: 939 VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993 ++ ++ + L S KF L F+ EAP ++G H Sbjct: 149 LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200 Query: 994 ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049 + + A ++S Q + P + + GS + + GD + + P N V Sbjct: 201 EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259 Query: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108 + L P ++ +L+ R + + RLP PC++ +YLDI + Sbjct: 260 QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308 Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164 P + A L+ E E+++LL S + E +++ P TI+EVL +FP + +P Sbjct: 309 PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368 Query: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223 LL + +++PR +SI+SS +P + + VA+V ++TR E G+CSSWL + Sbjct: 369 PDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLD 426 Query: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281 Q VP +VR S P P P I+VGPGTG+APFR+ Q+R Q Sbjct: 427 PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 481 Query: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREP--------DKPKKYVQDILQ 1333 L FGCR D Y E Q K L A+SRE + K YVQ L+ Sbjct: 482 --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLR 538 Query: 1334 EQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDD 1392 E L V+ L QG + Y+ G+ +M ADV +A+ I ++G L + DA +++R++ Sbjct: 539 E-LGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQT 597 Query: 1393 NRYHED 1398 R+ + Sbjct: 598 RRFQTE 603 >gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c [Homo sapiens] Length = 590 Score = 183 bits (465), Expect = 9e-46 Identities = 177/658 (26%), Positives = 291/658 (44%), Gaps = 99/658 (15%) Query: 762 ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820 +L+ ++TG +Q ++ L E + +V +++ Y +V+L +E LV+ V +T G GDPP Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67 Query: 821 ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880 +N + F + P++ L Sbjct: 68 DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88 Query: 881 NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938 + F+V GLG +Y F + L +LGG +L + GD+ G + A W + Sbjct: 89 QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148 Query: 939 VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993 ++ ++ + L S KF L F+ EAP ++G H Sbjct: 149 LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200 Query: 994 ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049 + + A ++S Q + P + + GS + + GD + + P N V Sbjct: 201 EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259 Query: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108 + L P ++ +L+ R + + RLP PC++ +YLDI + Sbjct: 260 QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308 Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164 P + A L+ E E+++LL S + E +++ P TI+EVL +FP + +P Sbjct: 309 PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368 Query: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223 LL + +++PR +SI+SS + + VA+V ++TR E G+CSSWL + Sbjct: 369 PDYLLDLIPVIRPRAFSIASS-------LLILVAVVQFQTRLKEP--RRGLCSSWLASLD 419 Query: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281 Q VP +VR S P P P I+VGPGTG+APFR+ Q+R Q Sbjct: 420 PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 474 Query: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVY 1341 L FGCR D Y E Q K L A+SRE ++ K YVQ L+E L V+ Sbjct: 475 --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQEQ-KVYVQHRLRE-LGSLVW 529 Query: 1342 RALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHED 1398 L QG + Y+ G+ +M ADV +A+ I ++G L + DA +++R++ R+ + Sbjct: 530 ELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTE 587 >gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d [Homo sapiens] Length = 521 Score = 154 bits (388), Expect = 8e-37 Identities = 160/604 (26%), Positives = 254/604 (42%), Gaps = 121/604 (20%) Query: 762 ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820 +L+ ++TG +Q ++ L E + +V +++ Y +V+L +E LV+ V +T G GDPP Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67 Query: 821 ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880 +N + F + P++ L Sbjct: 68 DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88 Query: 881 NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVF 940 + F+V GLG +Y F + L +LGG +L + Sbjct: 89 QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPV--------------------- 127 Query: 941 KAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH------ 993 C+GDD + +KF L F+ EAP ++G H Sbjct: 128 -------CLGDDQH------------ELGLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEP 168 Query: 994 --KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNA 1051 + + A ++S Q + P + + GS + + GD + + P N V Sbjct: 169 PSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHVQR 227 Query: 1052 LIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTPPT 1110 + L P ++ +L+ R + + RLP PC++ +YLDI + P Sbjct: 228 FCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASVPR 276 Query: 1111 PLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMPAT 1166 + A L+ E E+++LL S + E +++ P TI+EVL +FP + +P Sbjct: 277 RSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPD 336 Query: 1167 LLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI--- 1223 LL + +++PR +SI+SS +P + + VA+V ++TR E G+CSSWL + Sbjct: 337 YLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLDPG 394 Query: 1224 QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMV 1283 Q VP +VR S P P P I+VGPGTG+APFR+ Q+R Q Sbjct: 395 QGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF------ 447 Query: 1284 LVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRA 1343 L FGCR D Y E Q K L A+SRE ++ K YVQ L+E L V+ Sbjct: 448 LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQEQ-KVYVQHRLRE-LGSLVWEL 504 Query: 1344 LKEQ 1347 L Q Sbjct: 505 LDRQ 508 >gi|18375650 protein tyrosine phosphatase, non-receptor type 13 isoform 4 [Homo sapiens] Length = 2490 Score = 58.2 bits (139), Expect = 6e-08 Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%) Query: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53 ++D+ F ++ N V+LFK GLGF L+ E+++ V + L G A Sbjct: 1493 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1548 Query: 54 QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109 +SG I GD+IL VNG L LS + LRG A E +L+ R P G ++T Sbjct: 1549 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1603 Score = 40.8 bits (94), Expect = 0.009 Identities = 21/55 (38%), Positives = 30/55 (54%) Query: 41 VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95 + + +I GAAE G I GD +LAVNG L ++ A+E LR H++L Sbjct: 1400 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1454 Score = 38.1 bits (87), Expect = 0.061 Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%) Query: 8 VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63 V + + V L K GLGF + E++ + + IS + GG A+ G ++ GD Sbjct: 1084 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1143 Query: 64 ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95 +++VN L +S+ +A+E+L+ + +V+ Sbjct: 1144 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175 >gi|18375648 protein tyrosine phosphatase, non-receptor type 13 isoform 3 [Homo sapiens] Length = 2294 Score = 58.2 bits (139), Expect = 6e-08 Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%) Query: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53 ++D+ F ++ N V+LFK GLGF L+ E+++ V + L G A Sbjct: 1297 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1352 Query: 54 QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109 +SG I GD+IL VNG L LS + LRG A E +L+ R P G ++T Sbjct: 1353 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1407 Score = 40.8 bits (94), Expect = 0.009 Identities = 21/55 (38%), Positives = 30/55 (54%) Query: 41 VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95 + + +I GAAE G I GD +LAVNG L ++ A+E LR H++L Sbjct: 1204 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1258 Score = 38.1 bits (87), Expect = 0.061 Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%) Query: 8 VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63 V + + V L K GLGF + E++ + + IS + GG A+ G ++ GD Sbjct: 893 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 952 Query: 64 ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95 +++VN L +S+ +A+E+L+ + +V+ Sbjct: 953 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 984 >gi|18375646 protein tyrosine phosphatase, non-receptor type 13 isoform 1 [Homo sapiens] Length = 2485 Score = 58.2 bits (139), Expect = 6e-08 Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%) Query: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53 ++D+ F ++ N V+LFK GLGF L+ E+++ V + L G A Sbjct: 1488 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1543 Query: 54 QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109 +SG I GD+IL VNG L LS + LRG A E +L+ R P G ++T Sbjct: 1544 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1598 Score = 40.8 bits (94), Expect = 0.009 Identities = 21/55 (38%), Positives = 30/55 (54%) Query: 41 VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95 + + +I GAAE G I GD +LAVNG L ++ A+E LR H++L Sbjct: 1395 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1449 Score = 38.1 bits (87), Expect = 0.061 Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%) Query: 8 VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63 V + + V L K GLGF + E++ + + IS + GG A+ G ++ GD Sbjct: 1084 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1143 Query: 64 ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95 +++VN L +S+ +A+E+L+ + +V+ Sbjct: 1144 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175 >gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform 2 [Homo sapiens] Length = 2466 Score = 58.2 bits (139), Expect = 6e-08 Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%) Query: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53 ++D+ F ++ N V+LFK GLGF L+ E+++ V + L G A Sbjct: 1469 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1524 Query: 54 QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109 +SG I GD+IL VNG L LS + LRG A E +L+ R P G ++T Sbjct: 1525 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1579 Score = 40.8 bits (94), Expect = 0.009 Identities = 21/55 (38%), Positives = 30/55 (54%) Query: 41 VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95 + + +I GAAE G I GD +LAVNG L ++ A+E LR H++L Sbjct: 1376 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1430 Score = 38.1 bits (87), Expect = 0.061 Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%) Query: 8 VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63 V + + V L K GLGF + E++ + + IS + GG A+ G ++ GD Sbjct: 1065 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1124 Query: 64 ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95 +++VN L +S+ +A+E+L+ + +V+ Sbjct: 1125 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1156 >gi|11321640 basic beta 1 syntrophin [Homo sapiens] Length = 538 Score = 57.0 bits (136), Expect = 1e-07 Identities = 28/74 (37%), Positives = 49/74 (66%), Gaps = 1/74 (1%) Query: 18 VRLFKRKVGGLGFLVKE-RVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLS 76 V++ K+++GGLG +K + +K P++IS + +G AA+Q+ + GD IL+VNG L D + Sbjct: 113 VKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDAT 172 Query: 77 YDSALEVLRGIASE 90 +D A++ L+ E Sbjct: 173 HDEAVQALKRAGKE 186 >gi|5803177 basic beta 2 syntrophin [Homo sapiens] Length = 540 Score = 57.0 bits (136), Expect = 1e-07 Identities = 31/79 (39%), Positives = 49/79 (62%), Gaps = 1/79 (1%) Query: 13 PNVISVRLFKRKVGGLGFLVKE-RVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRP 71 P V VR+ K++ GGLG +K R ++ P++IS + G AA+QS ++ GD IL+VNG Sbjct: 111 PPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTD 170 Query: 72 LVDLSYDSALEVLRGIASE 90 L ++D A++ L+ E Sbjct: 171 LRQATHDQAVQALKRAGKE 189 >gi|87196343 PDZ domain containing 2 [Homo sapiens] Length = 2839 Score = 55.8 bits (133), Expect = 3e-07 Identities = 27/59 (45%), Positives = 43/59 (72%), Gaps = 1/59 (1%) Query: 40 PVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILR 98 P++I + +GGAAEQ+G+I+AGD ILA+NG+PLV L + A +++ + E V L++R Sbjct: 2776 PLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSV-PEGPVQLLIR 2833 Score = 45.8 bits (107), Expect = 3e-04 Identities = 53/213 (24%), Positives = 88/213 (41%), Gaps = 21/213 (9%) Query: 27 GLGFLVK----ERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALE 82 GLG V + S ++++ + GGAA + G + GD +L +NG LV LS++ A+ Sbjct: 343 GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402 Query: 83 VLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPPAG 142 +LR ++ V L++ E L T P +T + + D Q G Sbjct: 403 ILR--SATGMVQLVVASKENSAEDL-LRLTSKSLPD---LTSSVEDVSSWTDNEDQEADG 456 Query: 143 KEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAPRP-PGQDPAKKATRVS-----L 196 +E +G S D+ Q+ + G P G + K +R+S L Sbjct: 457 EED----EGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRL 512 Query: 197 QGRGENNELL-KEIEPVLSLLTSGSRGVKGGAP 228 + E NEL+ + +P + +L G K P Sbjct: 513 ESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLP 545 Score = 45.1 bits (105), Expect = 5e-04 Identities = 28/91 (30%), Positives = 51/91 (56%), Gaps = 5/91 (5%) Query: 11 IQPNVISV-RLFKRKVGGLGFLV---KERV-SKPPVIISDLIRGGAAEQSGLIQAGDIIL 65 I+P+VIS+ L+K K GLGF + ++ + + + + + G+A + G ++ GD IL Sbjct: 579 IRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEIL 638 Query: 66 AVNGRPLVDLSYDSALEVLRGIASETHVVLI 96 VNG P+ L++ A+ + I S V+ + Sbjct: 639 DVNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669 Score = 42.0 bits (97), Expect = 0.004 Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 2/89 (2%) Query: 12 QPNVISVRLFKRKVGGLGFLVKERVSKPP--VIISDLIRGGAAEQSGLIQAGDIILAVNG 69 + +V + L +++ GLGF V P + + + GAA Q G + GD +L+VNG Sbjct: 2617 EEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNG 2676 Query: 70 RPLVDLSYDSALEVLRGIASETHVVLILR 98 L L++ + L+VL +++++ Sbjct: 2677 ASLAGLAHGNVLKVLHQAQLHKDALVVIK 2705 >gi|4507137 acidic alpha 1 syntrophin [Homo sapiens] Length = 505 Score = 55.1 bits (131), Expect = 5e-07 Identities = 40/124 (32%), Positives = 66/124 (53%), Gaps = 10/124 (8%) Query: 11 IQPNVISVRLFKRKVGGLGFLVKE-RVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69 +Q ++VR K GGLG +K R +K P++IS + +G AA+Q+ + GD IL+VNG Sbjct: 83 LQRRRVTVR--KADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNG 140 Query: 70 RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTG-----DGTPKTIRVTQ 124 L ++D A++VL+ E VVL ++ + + + + + G D P + Q Sbjct: 141 EDLSSATHDEAVQVLKKTGKE--VVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQ 198 Query: 125 PLGP 128 P P Sbjct: 199 PSSP 202 >gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 isoform 1 [Homo sapiens] Length = 1834 Score = 53.9 bits (128), Expect = 1e-06 Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 15/212 (7%) Query: 12 QPNVISVRLFKRKVGGLGFLVKERVS--KPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69 +P +I+V L K+ GL + + K + + +++GGAA+ G + AGD +L+V+G Sbjct: 1003 EPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDG 1062 Query: 70 RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLG-- 127 R LV LS + A E++ +S VV + +G H T +P R++ G Sbjct: 1063 RSLVGLSQERAAELMTRTSS---VVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSG 1119 Query: 128 ---PPTKAVDL-----SHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLA 179 P ++ +L + P + P A G + + S P+ Sbjct: 1120 KPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQP 1179 Query: 180 PRPPGQDPAKKATRVSLQGRGENNELLKEIEP 211 P P G+ T + N +E P Sbjct: 1180 PSPGGKSAYASGTTAKITSVSTGNLCTEEQTP 1211 >gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 isoform 2 [Homo sapiens] Length = 1651 Score = 53.9 bits (128), Expect = 1e-06 Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 15/212 (7%) Query: 12 QPNVISVRLFKRKVGGLGFLVKERVS--KPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69 +P +I+V L K+ GL + + K + + +++GGAA+ G + AGD +L+V+G Sbjct: 1004 EPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDG 1063 Query: 70 RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLG-- 127 R LV LS + A E++ +S VV + +G H T +P R++ G Sbjct: 1064 RSLVGLSQERAAELMTRTSS---VVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSG 1120 Query: 128 ---PPTKAVDL-----SHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLA 179 P ++ +L + P + P A G + + S P+ Sbjct: 1121 KPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQP 1180 Query: 180 PRPPGQDPAKKATRVSLQGRGENNELLKEIEP 211 P P G+ T + N +E P Sbjct: 1181 PSPGGKSAYASGTTAKITSVSTGNLCTEEQTP 1212 >gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 isoform 3 [Homo sapiens] Length = 1612 Score = 53.9 bits (128), Expect = 1e-06 Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 15/212 (7%) Query: 12 QPNVISVRLFKRKVGGLGFLVKERVS--KPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69 +P +I+V L K+ GL + + K + + +++GGAA+ G + AGD +L+V+G Sbjct: 988 EPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDG 1047 Query: 70 RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLG-- 127 R LV LS + A E++ +S VV + +G H T +P R++ G Sbjct: 1048 RSLVGLSQERAAELMTRTSS---VVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSG 1104 Query: 128 ---PPTKAVDL-----SHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLA 179 P ++ +L + P + P A G + + S P+ Sbjct: 1105 KPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQP 1164 Query: 180 PRPPGQDPAKKATRVSLQGRGENNELLKEIEP 211 P P G+ T + N +E P Sbjct: 1165 PSPGGKSAYASGTTAKITSVSTGNLCTEEQTP 1196 >gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] Length = 749 Score = 53.9 bits (128), Expect = 1e-06 Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 28/136 (20%) Query: 11 IQPNVISVRLFKRKVGGLGFLVKERVSKP------PVIISDLIRGGAAEQSGLIQAGDII 64 I V+ ++LFK G LGF + V + ++ +I GGAA++ G +Q GD + Sbjct: 136 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 194 Query: 65 LAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQ 124 L VN L +++++ A+ +L+ + E + G P TI +T Sbjct: 195 LMVNNYSLEEVTHEEAVAILKNTS-------------------EVVYLKVGKPTTIYMTD 235 Query: 125 PLGPPTKAVDLSHQPP 140 P GPP + S+ PP Sbjct: 236 PYGPPD--ITHSYSPP 249 Score = 45.4 bits (106), Expect = 4e-04 Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 1/77 (1%) Query: 27 GLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRG 86 GLGF + + +S ++ GG A+ SG +Q GD IL+VNG L S++ A L+G Sbjct: 327 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 386 Query: 87 IASETHVVLILRGPEGF 103 A +T ++ PE + Sbjct: 387 -AGQTVTIIAQYQPEDY 402 >gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] Length = 975 Score = 53.9 bits (128), Expect = 1e-06 Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 28/136 (20%) Query: 11 IQPNVISVRLFKRKVGGLGFLVKERVSKP------PVIISDLIRGGAAEQSGLIQAGDII 64 I V+ ++LFK G LGF + V + ++ +I GGAA++ G +Q GD + Sbjct: 292 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 350 Query: 65 LAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQ 124 L VN L +++++ A+ +L+ + E + G P TI +T Sbjct: 351 LMVNNYSLEEVTHEEAVAILKNTS-------------------EVVYLKVGKPTTIYMTD 391 Query: 125 PLGPPTKAVDLSHQPP 140 P GPP + S+ PP Sbjct: 392 PYGPPD--ITHSYSPP 405 Score = 45.4 bits (106), Expect = 4e-04 Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 1/77 (1%) Query: 27 GLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRG 86 GLGF + + +S ++ GG A+ SG +Q GD IL+VNG L S++ A L+G Sbjct: 535 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 594 Query: 87 IASETHVVLILRGPEGF 103 A +T ++ PE + Sbjct: 595 -AGQTVTIIAQYQPEDY 610 >gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] Length = 870 Score = 53.9 bits (128), Expect = 1e-06 Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 28/136 (20%) Query: 11 IQPNVISVRLFKRKVGGLGFLVKERVSKP------PVIISDLIRGGAAEQSGLIQAGDII 64 I V+ ++LFK G LGF + V + ++ +I GGAA++ G +Q GD + Sbjct: 187 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 245 Query: 65 LAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQ 124 L VN L +++++ A+ +L+ + E + G P TI +T Sbjct: 246 LMVNNYSLEEVTHEEAVAILKNTS-------------------EVVYLKVGKPTTIYMTD 286 Query: 125 PLGPPTKAVDLSHQPP 140 P GPP + S+ PP Sbjct: 287 PYGPPD--ITHSYSPP 300 Score = 45.4 bits (106), Expect = 4e-04 Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 1/77 (1%) Query: 27 GLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRG 86 GLGF + + +S ++ GG A+ SG +Q GD IL+VNG L S++ A L+G Sbjct: 430 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 489 Query: 87 IASETHVVLILRGPEGF 103 A +T ++ PE + Sbjct: 490 -AGQTVTIIAQYQPEDY 505 >gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sapiens] Length = 1287 Score = 53.9 bits (128), Expect = 1e-06 Identities = 40/97 (41%), Positives = 50/97 (51%), Gaps = 14/97 (14%) Query: 22 KRKVGGLGF----LVKERVSKPPVIISDLIR------GGAAEQSGLIQAGDIILAVNGRP 71 K+ GLGF + KE S + SDL+R G AE++G I AGDIILAVNGR Sbjct: 1061 KKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1117 Query: 72 LVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLE 108 L + L +LRG E +L+ R P G LE Sbjct: 1118 TEGLIFQEVLHLLRGAPQEV-TLLLCRPPPGALPELE 1153 Score = 38.1 bits (87), Expect = 0.061 Identities = 26/92 (28%), Positives = 49/92 (53%), Gaps = 6/92 (6%) Query: 15 VISVRLFKRKVGGLGFLVKERV----SKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGR 70 ++ V L + G GF++ E + P + IS +I GG AE++ I+ G ILA+N Sbjct: 751 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810 Query: 71 PLVDLSYDSALEVLRGIASETHVVLILRGPEG 102 L +++ A+ +++ S ++ LI+ +G Sbjct: 811 SLEGFTFNMAVRMIQN--SPDNIELIISQSKG 840 Score = 36.6 bits (83), Expect = 0.18 Identities = 32/119 (26%), Positives = 50/119 (42%), Gaps = 5/119 (4%) Query: 26 GGLGFLVKERVSKPP----VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSAL 81 G LGF V ++ + + ++ GG A + G I GD +L V+G L L++ A+ Sbjct: 936 GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 995 Query: 82 EVLRGIASETHVVLILRGPEGFTTHLETTFT-GDGTPKTIRVTQPLGPPTKAVDLSHQP 139 + L G +VL R P + GD VT G P+ V ++ P Sbjct: 996 QCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGP 1054 >gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo sapiens] Length = 320 Score = 53.9 bits (128), Expect = 1e-06 Identities = 40/97 (41%), Positives = 50/97 (51%), Gaps = 14/97 (14%) Query: 22 KRKVGGLGF----LVKERVSKPPVIISDLIR------GGAAEQSGLIQAGDIILAVNGRP 71 K+ GLGF + KE S + SDL+R G AE++G I AGDIILAVNGR Sbjct: 94 KKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150 Query: 72 LVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLE 108 L + L +LRG E +L+ R P G LE Sbjct: 151 TEGLIFQEVLHLLRGAPQEV-TLLLCRPPPGALPELE 186 >gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo sapiens] Length = 261 Score = 53.9 bits (128), Expect = 1e-06 Identities = 40/97 (41%), Positives = 50/97 (51%), Gaps = 14/97 (14%) Query: 22 KRKVGGLGF----LVKERVSKPPVIISDLIR------GGAAEQSGLIQAGDIILAVNGRP 71 K+ GLGF + KE S + SDL+R G AE++G I AGDIILAVNGR Sbjct: 35 KKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91 Query: 72 LVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLE 108 L + L +LRG E +L+ R P G LE Sbjct: 92 TEGLIFQEVLHLLRGAPQEV-TLLLCRPPPGALPELE 127 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.135 0.409 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 59,681,480 Number of Sequences: 37866 Number of extensions: 2987021 Number of successful extensions: 8460 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 105 Number of HSP's successfully gapped in prelim test: 78 Number of HSP's that attempted gapping in prelim test: 7966 Number of HSP's gapped (non-prelim): 504 length of query: 1434 length of database: 18,247,518 effective HSP length: 115 effective length of query: 1319 effective length of database: 13,892,928 effective search space: 18324772032 effective search space used: 18324772032 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.