Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 10835173
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
(1434 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens] 2928 0.0
gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens] 1392 0.0
gi|24041029 nitric oxide synthase 2A [Homo sapiens] 1232 0.0
gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens] 731 0.0
gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens] 724 0.0
gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens] 724 0.0
gi|127139033 cytochrome P450 reductase [Homo sapiens] 246 9e-65
gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens] 218 3e-56
gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens] 218 3e-56
gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [... 192 3e-48
gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a... 188 4e-47
gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c... 183 9e-46
gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d... 154 8e-37
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 58 6e-08
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 58 6e-08
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 58 6e-08
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 58 6e-08
gi|11321640 basic beta 1 syntrophin [Homo sapiens] 57 1e-07
gi|5803177 basic beta 2 syntrophin [Homo sapiens] 57 1e-07
gi|87196343 PDZ domain containing 2 [Homo sapiens] 56 3e-07
gi|4507137 acidic alpha 1 syntrophin [Homo sapiens] 55 5e-07
gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithora... 54 1e-06
gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithora... 54 1e-06
gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithora... 54 1e-06
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 54 1e-06
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 54 1e-06
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 54 1e-06
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 54 1e-06
gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo sa... 54 1e-06
gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo sap... 54 1e-06
>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
Length = 1434
Score = 2928 bits (7590), Expect = 0.0
Identities = 1434/1434 (100%), Positives = 1434/1434 (100%)
Query: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA 60
MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA
Sbjct: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA 60
Query: 61 GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI 120
GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI
Sbjct: 61 GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTI 120
Query: 121 RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP 180
RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP
Sbjct: 121 RVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAP 180
Query: 181 RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV 240
RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV
Sbjct: 181 RPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQV 240
Query: 241 DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS 300
DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS
Sbjct: 241 DRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPS 300
Query: 301 KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF 360
KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF
Sbjct: 301 KCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLF 360
Query: 361 PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC 420
PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC
Sbjct: 361 PLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRC 420
Query: 421 VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW 480
VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW
Sbjct: 421 VGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVW 480
Query: 481 NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ 540
NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ
Sbjct: 481 NSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQ 540
Query: 541 IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV 600
IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV
Sbjct: 541 IPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGV 600
Query: 601 RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT 660
RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT
Sbjct: 601 RDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSAT 660
Query: 661 ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV 720
ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV
Sbjct: 661 ESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHV 720
Query: 721 WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE 780
WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE
Sbjct: 721 WKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCE 780
Query: 781 IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ 840
IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ
Sbjct: 781 IFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQ 840
Query: 841 EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF 900
EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF
Sbjct: 841 EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAF 900
Query: 901 GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN 960
GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN
Sbjct: 901 GHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANN 960
Query: 961 SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV 1020
SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV
Sbjct: 961 SLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFV 1020
Query: 1021 RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV 1080
RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV
Sbjct: 1021 RLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGV 1080
Query: 1081 ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY 1140
ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY
Sbjct: 1081 ISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEY 1140
Query: 1141 EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV 1200
EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV
Sbjct: 1141 EEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIV 1200
Query: 1201 SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP 1260
SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP
Sbjct: 1201 SYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAP 1260
Query: 1261 FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE 1320
FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE
Sbjct: 1261 FRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSRE 1320
Query: 1321 PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE 1380
PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE
Sbjct: 1321 PDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAE 1380
Query: 1381 DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS 1434
DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS
Sbjct: 1381 DAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS 1434
>gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]
Length = 1203
Score = 1392 bits (3603), Expect = 0.0
Identities = 678/1149 (59%), Positives = 853/1149 (74%), Gaps = 17/1149 (1%)
Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337
P + + PP+S P + P+F +VKNWE + DTL ++ + CT C+
Sbjct: 47 PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100
Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396
GS++ P + RP QL A++FI+QYYSSIKR GS+AH +RL+EV E+ T
Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160
Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456
TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A MF YICNH+KYATN
Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220
Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516
+GNLRSAIT+FPQR G+ DFR+WNSQL+RYAGY+Q DGS GDPANV+ TE+CIQ GW
Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280
Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576
P GRFDVLPLLLQA + PELF +PPELVLEVP+ HP EWF LGL+WY LPAVSNML
Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340
Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636
LEIGGLEF A PFSGWYM TEIG R+ CD RYNILE+VA M+LD R TSSLWKD+A V
Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400
Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696
EIN+AVL+S+Q KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF
Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460
Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756
HQEM+NY L+P+F YQPDPW KGT T K FK++A AVK SA LMG MAK
Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516
Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816
RVKATILY +ETG++Q+YA+ L +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN
Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576
Query: 817 GDPPENGEKFGCALMEMRHPNSVQ---EERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNF 873
GDPPENGE F ALMEM P + E+ KSYK+RFNS+S S N
Sbjct: 577 GDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSNT 636
Query: 874 ESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFR 933
+SAG L +RF VFGLGSRAYPHFCAF AVDT LEELGGER+L++ +GDELCGQEEAFR
Sbjct: 637 DSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFR 696
Query: 934 TWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVH 993
WA+ F+AAC+ FCVG+D + A + S RSWKR ++RL+ AE +L GL +VH
Sbjct: 697 GWAQAAFQAACETFCVGEDA--KAAARDIFSPKRSWKRQRYRLSAQAEGLQLLPGLIHVH 754
Query: 994 KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALI 1053
++++ A + S +NLQS KS+R+TI VRL T G + LQYQPGDH+GV P N LV AL+
Sbjct: 755 RRKMFQATIRSVENLQSSKSTRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALL 814
Query: 1054 ERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQ 1113
R+ED P + V VE LE+ + G W + RLPPCT+ QA ++LDIT+PP+P
Sbjct: 815 SRVEDPPAPTEPVAVEQLEKGSPG-GPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQL 873
Query: 1114 LQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLS 1173
L+ ++LA +E+Q L LS+ + YEEWKW + PT++EVLE+FPS+ +PA LLLTQL
Sbjct: 874 LRLLSTLAEEPREQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLP 933
Query: 1174 LLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADELVPCFV 1233
LLQPRYYS+SS+P +P E+HLTVA+++YRT+DG GP+H+GVCS+WL++++ + VPCF+
Sbjct: 934 LLQPRYYSVSSAPSTHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKPGDPVPCFI 993
Query: 1234 RGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKI 1293
RGAPSF LP +P +PCILVGPGTGIAPFR FWQ+R DI+ KG+ P PM LVFGCR S++
Sbjct: 994 RGAPSFRLPPDPSLPCILVGPGTGIAPFRGFWQERLHDIESKGLQPTPMTLVFGCRCSQL 1053
Query: 1294 DHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQGGHIYV 1353
DH+YR+E A+ +GVF + TA+SREPD PK YVQDIL+ +LA V+R L + GH++V
Sbjct: 1054 DHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQDILRTELAAEVHRVLCLERGHMFV 1113
Query: 1354 CGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRL 1413
CGDVTMA +VL+ +QRI+ +G + ++AG I +RD RYHEDIFG+TLRT EVT+R+
Sbjct: 1114 CGDVTMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRI 1173
Query: 1414 RSESIAFIE 1422
R++S + E
Sbjct: 1174 RTQSFSLQE 1182
>gi|24041029 nitric oxide synthase 2A [Homo sapiens]
Length = 1153
Score = 1232 bits (3187), Expect = 0.0
Identities = 615/1133 (54%), Positives = 779/1133 (68%), Gaps = 58/1133 (5%)
Query: 275 LNNPYSEKEQPPT-SGKQSPTK----NGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLET 329
L+ +E QP +GK+SP + +P PR +++KNW + + DTLH K+
Sbjct: 49 LSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGIL 108
Query: 330 GCTEYICMGSIMHPSQHARRPEDVRTK-GQLFPLAKEFIDQYYSSIKRFGSKAHMERLEE 388
C C+GSIM P R P D T +L P A EF++QYY S K + H+ R+E
Sbjct: 109 TCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEA 168
Query: 389 VNKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYIC 448
V KEI+TT TYQL ELI+ K AWRNA RC+GRIQWS LQVFDAR C+TA MF +IC
Sbjct: 169 VTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHIC 228
Query: 449 NHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTE 508
HV+Y+TN GN+RSAIT+FPQR+DGKHDFRVWN+QLIRYAGY+ PDGS GDPANV+FT+
Sbjct: 229 RHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQ 288
Query: 509 ICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYG 568
+CI GWKP GRFDV+PL+LQANG DPELF+IPP+LVLEV + HPK+EWF++L LKWY
Sbjct: 289 LCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYA 348
Query: 569 LPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSS 628
LPAV+NMLLE+GGLEF CPF+GWYMGTEIGVRD+CD RYNILEEV ++M L+ K +S
Sbjct: 349 LPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLAS 408
Query: 629 LWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPM 688
LWKDQA+VEINIAVL+SFQ VTI+DHHSA ESF+K+M+NEYR RGGCPADW+W+VPPM
Sbjct: 409 LWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPM 468
Query: 689 SGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAK 748
SGSITPVFHQEMLNY L+P + YQ + W THVW+ P KRR I K L +AV F+
Sbjct: 469 SGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRP-KRREIPLKVLVKAVLFACM 527
Query: 749 LMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVL 808
LM + MA RV+ TIL+ATETGKS+A A L +F AF+ KV+ M++Y + LE E L+L
Sbjct: 528 LMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLL 587
Query: 809 VVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPD 868
VVTSTFGNGD P NGEK +L ++ N+
Sbjct: 588 VVTSTFGNGDCPGNGEKLKKSLFMLKELNN------------------------------ 617
Query: 869 LRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQ 928
R++VFGLGS YP FCAF H +D L LG ++ M EGDEL GQ
Sbjct: 618 ------------KFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQ 665
Query: 929 EEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQG 988
E+AFR+WA + FKAAC+ F V +I+ L +++ +W + +RL ++ +L++
Sbjct: 666 EDAFRSWAVQTFKAACETFDVRGKQHIQIP--KLYTSNVTWDPHHYRLVQDSQPLDLSKA 723
Query: 989 LSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDL 1048
LS++H K V RL SRQNLQSP SSR+TI V L Q L Y PG+HLGV PGN L
Sbjct: 724 LSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPAL 783
Query: 1049 VNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTP 1108
V ++ER+ D P +Q V++E L+E S W + RLPPC++ QA Y+LDITTP
Sbjct: 784 VQGILERVVDGPTPHQTVRLEALDESG------SYWVSDKRLPPCSLSQALTYFLDITTP 837
Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLL 1168
PT L LQ+ A +AT E E+QRL L + EY +WK+ +PT +EVLEEFPS+++ A L
Sbjct: 838 PTQLLLQKLAQVATEEPERQRLEALCQP-SEYSKWKFTNSPTFLEVLEEFPSLRVSAGFL 896
Query: 1169 LTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADEL 1228
L+QL +L+PR+YSISSS D P E+HLTVA+V+Y TRDG+GP+HHGVCS+WLN ++ +
Sbjct: 897 LSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDP 956
Query: 1229 VPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGC 1288
VPCFVR A FHLP +P PCIL+GPGTGIAPFRSFWQQR D QHKG+ M LVFGC
Sbjct: 957 VPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGC 1016
Query: 1289 RQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQG 1348
R+ DHIY+EE L+ KGV ++TAYSR P KPK YVQDIL++QLA V R L ++
Sbjct: 1017 RRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEP 1076
Query: 1349 GHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFG 1401
GH+YVCGDV MA DV +++++ + KL+ E + +++ RYHEDIFG
Sbjct: 1077 GHLYVCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFG 1129
>gi|231571329 nitric oxide synthase 3 isoform 3 [Homo sapiens]
Length = 614
Score = 731 bits (1887), Expect = 0.0
Identities = 354/562 (62%), Positives = 427/562 (75%), Gaps = 11/562 (1%)
Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337
P + + PP+S P + P+F +VKNWE + DTL ++ + CT C+
Sbjct: 47 PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100
Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396
GS++ P + RP QL A++FI+QYYSSIKR GS+AH +RL+EV E+ T
Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160
Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456
TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A MF YICNH+KYATN
Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220
Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516
+GNLRSAIT+FPQR G+ DFR+WNSQL+RYAGY+Q DGS GDPANV+ TE+CIQ GW
Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280
Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576
P GRFDVLPLLLQA + PELF +PPELVLEVP+ HP EWF LGL+WY LPAVSNML
Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340
Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636
LEIGGLEF A PFSGWYM TEIG R+ CD RYNILE+VA M+LD R TSSLWKD+A V
Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400
Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696
EIN+AVL+S+Q KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF
Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460
Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756
HQEM+NY L+P+F YQPDPW KGT T K FK++A AVK SA LMG MAK
Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516
Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816
RVKATILY +ETG++Q+YA+ L +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN
Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576
Query: 817 GDPPENGEKFGCALMEMRHPNS 838
GDPPENGE++G A++ NS
Sbjct: 577 GDPPENGERWGFAMLPRLVSNS 598
>gi|231571356 nitric oxide synthase 3 isoform 4 [Homo sapiens]
Length = 629
Score = 724 bits (1870), Expect = 0.0
Identities = 350/548 (63%), Positives = 419/548 (76%), Gaps = 11/548 (2%)
Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337
P + + PP+S P + P+F +VKNWE + DTL ++ + CT C+
Sbjct: 47 PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100
Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396
GS++ P + RP QL A++FI+QYYSSIKR GS+AH +RL+EV E+ T
Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160
Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456
TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A MF YICNH+KYATN
Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220
Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516
+GNLRSAIT+FPQR G+ DFR+WNSQL+RYAGY+Q DGS GDPANV+ TE+CIQ GW
Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280
Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576
P GRFDVLPLLLQA + PELF +PPELVLEVP+ HP EWF LGL+WY LPAVSNML
Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340
Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636
LEIGGLEF A PFSGWYM TEIG R+ CD RYNILE+VA M+LD R TSSLWKD+A V
Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400
Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696
EIN+AVL+S+Q KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF
Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460
Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756
HQEM+NY L+P+F YQPDPW KGT T K FK++A AVK SA LMG MAK
Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516
Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816
RVKATILY +ETG++Q+YA+ L +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN
Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576
Query: 817 GDPPENGE 824
GDPPENGE
Sbjct: 577 GDPPENGE 584
>gi|231571314 nitric oxide synthase 3 isoform 2 [Homo sapiens]
Length = 596
Score = 724 bits (1870), Expect = 0.0
Identities = 350/548 (63%), Positives = 419/548 (76%), Gaps = 11/548 (2%)
Query: 278 PYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICM 337
P + + PP+S P + P+F +VKNWE + DTL ++ + CT C+
Sbjct: 47 PPAPEHSPPSSPLTQPPEG------PKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCL 100
Query: 338 GSIMHPSQHARRPED-VRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTT 396
GS++ P + RP QL A++FI+QYYSSIKR GS+AH +RL+EV E+ T
Sbjct: 101 GSLVFPRKLQGRPSPGPPAPEQLLSQARDFINQYYSSIKRSGSQAHEQRLQEVEAEVAAT 160
Query: 397 STYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATN 456
TYQL+++EL++GAK AWRNA RCVGRIQW KLQVFDARDC +A MF YICNH+KYATN
Sbjct: 161 GTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATN 220
Query: 457 KGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWK 516
+GNLRSAIT+FPQR G+ DFR+WNSQL+RYAGY+Q DGS GDPANV+ TE+CIQ GW
Sbjct: 221 RGNLRSAITVFPQRCPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWT 280
Query: 517 PPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNML 576
P GRFDVLPLLLQA + PELF +PPELVLEVP+ HP EWF LGL+WY LPAVSNML
Sbjct: 281 PGNGRFDVLPLLLQAPDDPPELFLLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNML 340
Query: 577 LEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALV 636
LEIGGLEF A PFSGWYM TEIG R+ CD RYNILE+VA M+LD R TSSLWKD+A V
Sbjct: 341 LEIGGLEFPAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAV 400
Query: 637 EINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVF 696
EIN+AVL+S+Q KVTIVDHH+AT SF+KH+ENE + RGGCPADW WIVPP+SGS+TPVF
Sbjct: 401 EINVAVLHSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVF 460
Query: 697 HQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAK 756
HQEM+NY L+P+F YQPDPW KGT T K FK++A AVK SA LMG MAK
Sbjct: 461 HQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKT----FKEVANAVKISASLMGTVMAK 516
Query: 757 RVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGN 816
RVKATILY +ETG++Q+YA+ L +F+ AFD +V+ M+EYD+V LEHETLVLVVTSTFGN
Sbjct: 517 RVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGN 576
Query: 817 GDPPENGE 824
GDPPENGE
Sbjct: 577 GDPPENGE 584
>gi|127139033 cytochrome P450 reductase [Homo sapiens]
Length = 680
Score = 246 bits (629), Expect = 9e-65
Identities = 195/675 (28%), Positives = 309/675 (45%), Gaps = 116/675 (17%)
Query: 762 ILYATETGKSQAYAKTLCEIFKHAFDAKVMSM--EEYDIVHLEH-----ETLVLVVTSTF 814
+ Y ++TG ++ +A L + H + + MS EEYD+ L LV+ +T+
Sbjct: 85 VFYGSQTGTAEEFANRLSKD-AHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATY 143
Query: 815 GNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFE 874
G GDP +N + F Y Q++ D
Sbjct: 144 GEGDPTDNAQDF-----------------------------YDWLQETDVD--------- 165
Query: 875 SAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRT 934
L+ V+F+VFGLG++ Y HF A G VD LE+LG +RI ++ GD+ EE F T
Sbjct: 166 ----LSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFIT 221
Query: 935 WAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHK 994
W ++ + A C+ F V + S ++ + + +A ++ G
Sbjct: 222 WREQFWPAVCEHFGV-----------EATGEESSIRQYELVVHTDIDAAKVYMG------ 264
Query: 995 KRVSAARLLSRQNLQSPKSSRSTIFVRLHTN------------------GSQELQYQPGD 1036
RL S +N + P +++ + TN +++Y+ GD
Sbjct: 265 ---EMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGD 321
Query: 1037 HLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIF 1096
H+ V+P N LVN L + L ++ ++ + L+E + P +
Sbjct: 322 HVAVYPANDSALVNQLGKIL--GADLDVVMSLNNLDEESNKKHPFPC--------PTSYR 371
Query: 1097 QAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLS----KGLQEYEEWKWGKNPTIV 1152
A YYLDIT PP L + A A+ E++ L ++ +G + Y W I+
Sbjct: 372 TALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHIL 431
Query: 1153 EVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIH 1212
+L++ PS++ P L L LQ RYYSI+SS ++P+ VH+ +V Y T+ G I+
Sbjct: 432 AILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGR--IN 489
Query: 1213 HGVCSSWLNRIQ------ADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQ 1266
GV ++WL + LVP FVR + F LP P I+VGPGTG+APF F Q
Sbjct: 490 KGVATNWLRAKEPAGENGGRALVPMFVRKS-QFRLPFKATTPVIMVGPGTGVAPFIGFIQ 548
Query: 1267 QRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKK 1326
+R + ++ +G +L +GCR+S D++YREE Q G +L A+SRE K
Sbjct: 549 ERAW-LRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSRE-QSHKV 606
Query: 1327 YVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVF 1385
YVQ +L++ E +++ L E G HIYVCGD MA DV I+ + G + A +
Sbjct: 607 YVQHLLKQD-REHLWK-LIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDY 664
Query: 1386 ISRMRDDNRYHEDIF 1400
I ++ RY D++
Sbjct: 665 IKKLMTKGRYSLDVW 679
>gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]
Length = 698
Score = 218 bits (556), Expect = 3e-56
Identities = 199/740 (26%), Positives = 313/740 (42%), Gaps = 149/740 (20%)
Query: 762 ILYATETGKSQAYAKTLCE-IFKHAFDAKVMSMEEYDIVHLEHETLVLVVT-STFGNGDP 819
+LYAT+ G+++A A+ +CE H F A + + E D L+ ET LVV ST G GDP
Sbjct: 6 LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 65
Query: 820 PENGEKFGCALMEMRHPNSVQE-ERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGP 878
P+ KF V+E + ++ V F
Sbjct: 66 PDTARKF------------VKEIQNQTLPVDF---------------------------- 85
Query: 879 LANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWA-- 936
A++R+ + GLG Y +FC G +D L+ELG D+ G E W
Sbjct: 86 FAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAG 145
Query: 937 -----KKVFKAA------------------------CDVFCVGDDVNIEKANNSLISNDR 967
+K F+++ ++ + V + + ++S +
Sbjct: 146 LWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSE 205
Query: 968 SWKRNK------------FRLTFVAEAPELTQGLSNV-----HKKRVSAARLLSRQNLQS 1010
K+N F + P L+Q N+ +V L ++ Q
Sbjct: 206 VLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQV 265
Query: 1011 PKSSRSTIF-------VRLHTN-------------GSQELQYQPGDHLGVFPGNHEDLVN 1050
+S +F V+L TN + + YQPGD V N + V
Sbjct: 266 SVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQ 325
Query: 1051 ALIERL--EDAPPVNQMVKVELLEERNTALGVISNWTDELRLPP-CTIFQAFKYYLDITT 1107
+L++RL ED ++K++ ++ A T +P C++ F + L+I
Sbjct: 326 SLLQRLQLEDKREHCVLLKIKADTKKKGA-------TLPQHIPAGCSLQFIFTWCLEIRA 378
Query: 1108 PPTPLQLQQFASLATSEKEKQRL--LVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPA 1165
P L+ + EK+RL L +G +Y + ++++L FPS Q P
Sbjct: 379 IPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPL 438
Query: 1166 TLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQA 1225
+LLL L LQPR YS +SS +P ++H IV + + + GVC+ WL + A
Sbjct: 439 SLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVA 498
Query: 1226 DELVP------------------CFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQ 1267
L P R SFHLP +P +P I+VGPGTGIAPF F Q
Sbjct: 499 SVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQH 558
Query: 1268 RQ-FDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSR-----EP 1321
R+ QH N M L FGCR D+++R+E G+ L ++SR E
Sbjct: 559 REKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEE 618
Query: 1322 DKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAE 1380
+ P KYVQD +Q + V R L ++ GHIYVCGD MA DV A+ +I++++ +
Sbjct: 619 EAPAKYVQDNIQLH-GQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKL 677
Query: 1381 DAGVFISRMRDDNRYHEDIF 1400
+A ++ ++++ RY +DI+
Sbjct: 678 EAMKTLATLKEEKRYLQDIW 697
>gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]
Length = 725
Score = 218 bits (556), Expect = 3e-56
Identities = 199/740 (26%), Positives = 313/740 (42%), Gaps = 149/740 (20%)
Query: 762 ILYATETGKSQAYAKTLCE-IFKHAFDAKVMSMEEYDIVHLEHETLVLVVT-STFGNGDP 819
+LYAT+ G+++A A+ +CE H F A + + E D L+ ET LVV ST G GDP
Sbjct: 33 LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDP 92
Query: 820 PENGEKFGCALMEMRHPNSVQE-ERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGP 878
P+ KF V+E + ++ V F
Sbjct: 93 PDTARKF------------VKEIQNQTLPVDF---------------------------- 112
Query: 879 LANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWA-- 936
A++R+ + GLG Y +FC G +D L+ELG D+ G E W
Sbjct: 113 FAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAG 172
Query: 937 -----KKVFKAA------------------------CDVFCVGDDVNIEKANNSLISNDR 967
+K F+++ ++ + V + + ++S +
Sbjct: 173 LWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSE 232
Query: 968 SWKRNK------------FRLTFVAEAPELTQGLSNV-----HKKRVSAARLLSRQNLQS 1010
K+N F + P L+Q N+ +V L ++ Q
Sbjct: 233 VLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQV 292
Query: 1011 PKSSRSTIF-------VRLHTN-------------GSQELQYQPGDHLGVFPGNHEDLVN 1050
+S +F V+L TN + + YQPGD V N + V
Sbjct: 293 SVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQ 352
Query: 1051 ALIERL--EDAPPVNQMVKVELLEERNTALGVISNWTDELRLPP-CTIFQAFKYYLDITT 1107
+L++RL ED ++K++ ++ A T +P C++ F + L+I
Sbjct: 353 SLLQRLQLEDKREHCVLLKIKADTKKKGA-------TLPQHIPAGCSLQFIFTWCLEIRA 405
Query: 1108 PPTPLQLQQFASLATSEKEKQRL--LVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPA 1165
P L+ + EK+RL L +G +Y + ++++L FPS Q P
Sbjct: 406 IPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPL 465
Query: 1166 TLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQA 1225
+LLL L LQPR YS +SS +P ++H IV + + + GVC+ WL + A
Sbjct: 466 SLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVA 525
Query: 1226 DELVP------------------CFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQ 1267
L P R SFHLP +P +P I+VGPGTGIAPF F Q
Sbjct: 526 SVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQH 585
Query: 1268 RQ-FDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSR-----EP 1321
R+ QH N M L FGCR D+++R+E G+ L ++SR E
Sbjct: 586 REKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEE 645
Query: 1322 DKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAE 1380
+ P KYVQD +Q + V R L ++ GHIYVCGD MA DV A+ +I++++ +
Sbjct: 646 EAPAKYVQDNIQLH-GQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKL 704
Query: 1381 DAGVFISRMRDDNRYHEDIF 1400
+A ++ ++++ RY +DI+
Sbjct: 705 EAMKTLATLKEEKRYLQDIW 724
>gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [Homo
sapiens]
Length = 597
Score = 192 bits (487), Expect = 3e-48
Identities = 178/658 (27%), Positives = 293/658 (44%), Gaps = 92/658 (13%)
Query: 762 ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820
+L+ ++TG +Q ++ L E + +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
Query: 821 ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880
+N + F + P++ L
Sbjct: 68 DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88
Query: 881 NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938
+ F+V GLG +Y F + L +LGG +L + GD+ G + A W +
Sbjct: 89 QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148
Query: 939 VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993
++ ++ + L S KF L F+ EAP ++G H
Sbjct: 149 LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200
Query: 994 ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049
+ + A ++S Q + P + + GS + + GD + + P N V
Sbjct: 201 EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259
Query: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108
+ L P ++ +L+ R + + RLP PC++ +YLDI +
Sbjct: 260 QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308
Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164
P + A L+ E E+++LL S + E +++ P TI+EVL +FP + +P
Sbjct: 309 PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368
Query: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223
LL + +++PR +SI+SS +P + + VA+V ++TR E G+CSSWL +
Sbjct: 369 PDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLD 426
Query: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281
Q VP +VR S P P P I+VGPGTG+APFR+ Q+R Q
Sbjct: 427 PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 481
Query: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVY 1341
L FGCR D Y E Q K L A+SRE ++ K YVQ L+E L V+
Sbjct: 482 --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQEQ-KVYVQHRLRE-LGSLVW 536
Query: 1342 RALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHED 1398
L QG + Y+ G+ +M ADV +A+ I ++G L + DA +++R++ R+ +
Sbjct: 537 ELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTE 594
>gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a
[Homo sapiens]
Length = 606
Score = 188 bits (477), Expect = 4e-47
Identities = 178/666 (26%), Positives = 292/666 (43%), Gaps = 99/666 (14%)
Query: 762 ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820
+L+ ++TG +Q ++ L E + +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
Query: 821 ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880
+N + F + P++ L
Sbjct: 68 DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88
Query: 881 NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938
+ F+V GLG +Y F + L +LGG +L + GD+ G + A W +
Sbjct: 89 QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148
Query: 939 VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993
++ ++ + L S KF L F+ EAP ++G H
Sbjct: 149 LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200
Query: 994 ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049
+ + A ++S Q + P + + GS + + GD + + P N V
Sbjct: 201 EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259
Query: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108
+ L P ++ +L+ R + + RLP PC++ +YLDI +
Sbjct: 260 QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308
Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164
P + A L+ E E+++LL S + E +++ P TI+EVL +FP + +P
Sbjct: 309 PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368
Query: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223
LL + +++PR +SI+SS +P + + VA+V ++TR E G+CSSWL +
Sbjct: 369 PDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLD 426
Query: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281
Q VP +VR S P P P I+VGPGTG+APFR+ Q+R Q
Sbjct: 427 PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 481
Query: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREP--------DKPKKYVQDILQ 1333
L FGCR D Y E Q K L A+SRE + K YVQ L+
Sbjct: 482 --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQPPALFSALQEQKVYVQHRLR 538
Query: 1334 EQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDD 1392
E L V+ L QG + Y+ G+ +M ADV +A+ I ++G L + DA +++R++
Sbjct: 539 E-LGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQT 597
Query: 1393 NRYHED 1398
R+ +
Sbjct: 598 RRFQTE 603
>gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c
[Homo sapiens]
Length = 590
Score = 183 bits (465), Expect = 9e-46
Identities = 177/658 (26%), Positives = 291/658 (44%), Gaps = 99/658 (15%)
Query: 762 ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820
+L+ ++TG +Q ++ L E + +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
Query: 821 ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880
+N + F + P++ L
Sbjct: 68 DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88
Query: 881 NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDEL--CGQEEAFRTWAKK 938
+ F+V GLG +Y F + L +LGG +L + GD+ G + A W +
Sbjct: 89 QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRD 148
Query: 939 VFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH---- 993
++ ++ + L S KF L F+ EAP ++G H
Sbjct: 149 LWDRVLGLYPPPPGLTEIPPGVPLPS--------KFTLLFLQEAPSTGSEGQRVAHPGSQ 200
Query: 994 ----KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLV 1049
+ + A ++S Q + P + + GS + + GD + + P N V
Sbjct: 201 EPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHV 259
Query: 1050 NALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTP 1108
+ L P ++ +L+ R + + RLP PC++ +YLDI +
Sbjct: 260 QRFCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASV 308
Query: 1109 PTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMP 1164
P + A L+ E E+++LL S + E +++ P TI+EVL +FP + +P
Sbjct: 309 PRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIP 368
Query: 1165 ATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI- 1223
LL + +++PR +SI+SS + + VA+V ++TR E G+CSSWL +
Sbjct: 369 PDYLLDLIPVIRPRAFSIASS-------LLILVAVVQFQTRLKEP--RRGLCSSWLASLD 419
Query: 1224 --QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCP 1281
Q VP +VR S P P P I+VGPGTG+APFR+ Q+R Q
Sbjct: 420 PGQGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF---- 474
Query: 1282 MVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVY 1341
L FGCR D Y E Q K L A+SRE ++ K YVQ L+E L V+
Sbjct: 475 --LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQEQ-KVYVQHRLRE-LGSLVW 529
Query: 1342 RALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHED 1398
L QG + Y+ G+ +M ADV +A+ I ++G L + DA +++R++ R+ +
Sbjct: 530 ELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTE 587
>gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d
[Homo sapiens]
Length = 521
Score = 154 bits (388), Expect = 8e-37
Identities = 160/604 (26%), Positives = 254/604 (42%), Gaps = 121/604 (20%)
Query: 762 ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPP 820
+L+ ++TG +Q ++ L E + +V +++ Y +V+L +E LV+ V +T G GDPP
Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPP 67
Query: 821 ENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLA 880
+N + F + P++ L
Sbjct: 68 DNMKNFWRFIFRKNLPSTA---------------------------------------LC 88
Query: 881 NVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVF 940
+ F+V GLG +Y F + L +LGG +L +
Sbjct: 89 QMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPV--------------------- 127
Query: 941 KAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPEL-TQGLSNVH------ 993
C+GDD + +KF L F+ EAP ++G H
Sbjct: 128 -------CLGDDQH------------ELGLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEP 168
Query: 994 --KKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNA 1051
+ + A ++S Q + P + + GS + + GD + + P N V
Sbjct: 169 PSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSG-ISFAAGDVVLIQPSNSAAHVQR 227
Query: 1052 LIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLP-PCTIFQAFKYYLDITTPPT 1110
+ L P ++ +L+ R + + RLP PC++ +YLDI + P
Sbjct: 228 FCQVLGLDPD-----QLFMLQPREPDV------SSPTRLPQPCSMRHLVSHYLDIASVPR 276
Query: 1111 PLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNP--TIVEVLEEFP--SIQMPAT 1166
+ A L+ E E+++LL S + E +++ P TI+EVL +FP + +P
Sbjct: 277 RSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPD 336
Query: 1167 LLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRI--- 1223
LL + +++PR +SI+SS +P + + VA+V ++TR E G+CSSWL +
Sbjct: 337 YLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEP--RRGLCSSWLASLDPG 394
Query: 1224 QADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMV 1283
Q VP +VR S P P P I+VGPGTG+APFR+ Q+R Q
Sbjct: 395 QGPVRVPLWVRPG-SLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNF------ 447
Query: 1284 LVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRA 1343
L FGCR D Y E Q K L A+SRE ++ K YVQ L+E L V+
Sbjct: 448 LFFGCRWRDQD-FYWEAEWQELEKRDCLTLIPAFSREQEQ-KVYVQHRLRE-LGSLVWEL 504
Query: 1344 LKEQ 1347
L Q
Sbjct: 505 LDRQ 508
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 58.2 bits (139), Expect = 6e-08
Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%)
Query: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53
++D+ F ++ N V+LFK GLGF L+ E+++ V + L G A
Sbjct: 1493 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1548
Query: 54 QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109
+SG I GD+IL VNG L LS + LRG A E +L+ R P G ++T
Sbjct: 1549 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1603
Score = 40.8 bits (94), Expect = 0.009
Identities = 21/55 (38%), Positives = 30/55 (54%)
Query: 41 VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
+ + +I GAAE G I GD +LAVNG L ++ A+E LR H++L
Sbjct: 1400 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1454
Score = 38.1 bits (87), Expect = 0.061
Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%)
Query: 8 VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63
V + + V L K GLGF + E++ + + IS + GG A+ G ++ GD
Sbjct: 1084 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1143
Query: 64 ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
+++VN L +S+ +A+E+L+ + +V+
Sbjct: 1144 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 58.2 bits (139), Expect = 6e-08
Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%)
Query: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53
++D+ F ++ N V+LFK GLGF L+ E+++ V + L G A
Sbjct: 1297 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1352
Query: 54 QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109
+SG I GD+IL VNG L LS + LRG A E +L+ R P G ++T
Sbjct: 1353 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1407
Score = 40.8 bits (94), Expect = 0.009
Identities = 21/55 (38%), Positives = 30/55 (54%)
Query: 41 VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
+ + +I GAAE G I GD +LAVNG L ++ A+E LR H++L
Sbjct: 1204 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1258
Score = 38.1 bits (87), Expect = 0.061
Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%)
Query: 8 VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63
V + + V L K GLGF + E++ + + IS + GG A+ G ++ GD
Sbjct: 893 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 952
Query: 64 ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
+++VN L +S+ +A+E+L+ + +V+
Sbjct: 953 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 984
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 58.2 bits (139), Expect = 6e-08
Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%)
Query: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53
++D+ F ++ N V+LFK GLGF L+ E+++ V + L G A
Sbjct: 1488 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1543
Query: 54 QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109
+SG I GD+IL VNG L LS + LRG A E +L+ R P G ++T
Sbjct: 1544 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1598
Score = 40.8 bits (94), Expect = 0.009
Identities = 21/55 (38%), Positives = 30/55 (54%)
Query: 41 VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
+ + +I GAAE G I GD +LAVNG L ++ A+E LR H++L
Sbjct: 1395 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1449
Score = 38.1 bits (87), Expect = 0.061
Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%)
Query: 8 VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63
V + + V L K GLGF + E++ + + IS + GG A+ G ++ GD
Sbjct: 1084 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1143
Query: 64 ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
+++VN L +S+ +A+E+L+ + +V+
Sbjct: 1144 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 58.2 bits (139), Expect = 6e-08
Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 12/116 (10%)
Query: 1 MEDHMFGVQQIQPNVISVRLFKRKVGGLGF-------LVKERVSKPPVIISDLIRGGAAE 53
++D+ F ++ N V+LFK GLGF L+ E+++ V + L G A
Sbjct: 1469 VKDYSFVTEE---NTFEVKLFKNS-SGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAA 1524
Query: 54 QSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLET 109
+SG I GD+IL VNG L LS + LRG A E +L+ R P G ++T
Sbjct: 1525 ESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEV-FLLLCRPPPGVLPEIDT 1579
Score = 40.8 bits (94), Expect = 0.009
Identities = 21/55 (38%), Positives = 30/55 (54%)
Query: 41 VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
+ + +I GAAE G I GD +LAVNG L ++ A+E LR H++L
Sbjct: 1376 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL 1430
Score = 38.1 bits (87), Expect = 0.061
Identities = 25/92 (27%), Positives = 48/92 (52%), Gaps = 4/92 (4%)
Query: 8 VQQIQPNVISVRLFKRKVGGLGFLV--KERVSKPP--VIISDLIRGGAAEQSGLIQAGDI 63
V + + V L K GLGF + E++ + + IS + GG A+ G ++ GD
Sbjct: 1065 VSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDR 1124
Query: 64 ILAVNGRPLVDLSYDSALEVLRGIASETHVVL 95
+++VN L +S+ +A+E+L+ + +V+
Sbjct: 1125 LISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1156
>gi|11321640 basic beta 1 syntrophin [Homo sapiens]
Length = 538
Score = 57.0 bits (136), Expect = 1e-07
Identities = 28/74 (37%), Positives = 49/74 (66%), Gaps = 1/74 (1%)
Query: 18 VRLFKRKVGGLGFLVKE-RVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLS 76
V++ K+++GGLG +K + +K P++IS + +G AA+Q+ + GD IL+VNG L D +
Sbjct: 113 VKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDAT 172
Query: 77 YDSALEVLRGIASE 90
+D A++ L+ E
Sbjct: 173 HDEAVQALKRAGKE 186
>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
Length = 540
Score = 57.0 bits (136), Expect = 1e-07
Identities = 31/79 (39%), Positives = 49/79 (62%), Gaps = 1/79 (1%)
Query: 13 PNVISVRLFKRKVGGLGFLVKE-RVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRP 71
P V VR+ K++ GGLG +K R ++ P++IS + G AA+QS ++ GD IL+VNG
Sbjct: 111 PPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTD 170
Query: 72 LVDLSYDSALEVLRGIASE 90
L ++D A++ L+ E
Sbjct: 171 LRQATHDQAVQALKRAGKE 189
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 55.8 bits (133), Expect = 3e-07
Identities = 27/59 (45%), Positives = 43/59 (72%), Gaps = 1/59 (1%)
Query: 40 PVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILR 98
P++I + +GGAAEQ+G+I+AGD ILA+NG+PLV L + A +++ + E V L++R
Sbjct: 2776 PLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSV-PEGPVQLLIR 2833
Score = 45.8 bits (107), Expect = 3e-04
Identities = 53/213 (24%), Positives = 88/213 (41%), Gaps = 21/213 (9%)
Query: 27 GLGFLVK----ERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALE 82
GLG V + S ++++ + GGAA + G + GD +L +NG LV LS++ A+
Sbjct: 343 GLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402
Query: 83 VLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPPAG 142
+LR ++ V L++ E L T P +T + + D Q G
Sbjct: 403 ILR--SATGMVQLVVASKENSAEDL-LRLTSKSLPD---LTSSVEDVSSWTDNEDQEADG 456
Query: 143 KEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAPRP-PGQDPAKKATRVS-----L 196
+E +G S D+ Q+ + G P G + K +R+S L
Sbjct: 457 EED----EGTSSSVQRAMPGTDEPQDVCGAEESKGNLESPKQGSNKIKLKSRLSGGVHRL 512
Query: 197 QGRGENNELL-KEIEPVLSLLTSGSRGVKGGAP 228
+ E NEL+ + +P + +L G K P
Sbjct: 513 ESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLP 545
Score = 45.1 bits (105), Expect = 5e-04
Identities = 28/91 (30%), Positives = 51/91 (56%), Gaps = 5/91 (5%)
Query: 11 IQPNVISV-RLFKRKVGGLGFLV---KERV-SKPPVIISDLIRGGAAEQSGLIQAGDIIL 65
I+P+VIS+ L+K K GLGF + ++ + + + + + G+A + G ++ GD IL
Sbjct: 579 IRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEIL 638
Query: 66 AVNGRPLVDLSYDSALEVLRGIASETHVVLI 96
VNG P+ L++ A+ + I S V+ +
Sbjct: 639 DVNGIPIKGLTFQEAIHTFKQIRSGLFVLTV 669
Score = 42.0 bits (97), Expect = 0.004
Identities = 24/89 (26%), Positives = 45/89 (50%), Gaps = 2/89 (2%)
Query: 12 QPNVISVRLFKRKVGGLGFLVKERVSKPP--VIISDLIRGGAAEQSGLIQAGDIILAVNG 69
+ +V + L +++ GLGF V P + + + GAA Q G + GD +L+VNG
Sbjct: 2617 EEDVCFIVLNRKEGSGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNG 2676
Query: 70 RPLVDLSYDSALEVLRGIASETHVVLILR 98
L L++ + L+VL +++++
Sbjct: 2677 ASLAGLAHGNVLKVLHQAQLHKDALVVIK 2705
>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
Length = 505
Score = 55.1 bits (131), Expect = 5e-07
Identities = 40/124 (32%), Positives = 66/124 (53%), Gaps = 10/124 (8%)
Query: 11 IQPNVISVRLFKRKVGGLGFLVKE-RVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69
+Q ++VR K GGLG +K R +K P++IS + +G AA+Q+ + GD IL+VNG
Sbjct: 83 LQRRRVTVR--KADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNG 140
Query: 70 RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTG-----DGTPKTIRVTQ 124
L ++D A++VL+ E VVL ++ + + + + + G D P + Q
Sbjct: 141 EDLSSATHDEAVQVLKKTGKE--VVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQ 198
Query: 125 PLGP 128
P P
Sbjct: 199 PSSP 202
>gi|90819237 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 1 [Homo
sapiens]
Length = 1834
Score = 53.9 bits (128), Expect = 1e-06
Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 15/212 (7%)
Query: 12 QPNVISVRLFKRKVGGLGFLVKERVS--KPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69
+P +I+V L K+ GL + + K + + +++GGAA+ G + AGD +L+V+G
Sbjct: 1003 EPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDG 1062
Query: 70 RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLG-- 127
R LV LS + A E++ +S VV + +G H T +P R++ G
Sbjct: 1063 RSLVGLSQERAAELMTRTSS---VVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSG 1119
Query: 128 ---PPTKAVDL-----SHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLA 179
P ++ +L + P + P A G + + S P+
Sbjct: 1120 KPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQP 1179
Query: 180 PRPPGQDPAKKATRVSLQGRGENNELLKEIEP 211
P P G+ T + N +E P
Sbjct: 1180 PSPGGKSAYASGTTAKITSVSTGNLCTEEQTP 1211
>gi|90819233 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 2 [Homo
sapiens]
Length = 1651
Score = 53.9 bits (128), Expect = 1e-06
Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 15/212 (7%)
Query: 12 QPNVISVRLFKRKVGGLGFLVKERVS--KPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69
+P +I+V L K+ GL + + K + + +++GGAA+ G + AGD +L+V+G
Sbjct: 1004 EPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDG 1063
Query: 70 RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLG-- 127
R LV LS + A E++ +S VV + +G H T +P R++ G
Sbjct: 1064 RSLVGLSQERAAELMTRTSS---VVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSG 1120
Query: 128 ---PPTKAVDL-----SHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLA 179
P ++ +L + P + P A G + + S P+
Sbjct: 1121 KPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQP 1180
Query: 180 PRPPGQDPAKKATRVSLQGRGENNELLKEIEP 211
P P G+ T + N +E P
Sbjct: 1181 PSPGGKSAYASGTTAKITSVSTGNLCTEEQTP 1212
>gi|90819231 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 4 isoform 3 [Homo
sapiens]
Length = 1612
Score = 53.9 bits (128), Expect = 1e-06
Identities = 50/212 (23%), Positives = 86/212 (40%), Gaps = 15/212 (7%)
Query: 12 QPNVISVRLFKRKVGGLGFLVKERVS--KPPVIISDLIRGGAAEQSGLIQAGDIILAVNG 69
+P +I+V L K+ GL + + K + + +++GGAA+ G + AGD +L+V+G
Sbjct: 988 EPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDG 1047
Query: 70 RPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLG-- 127
R LV LS + A E++ +S VV + +G H T +P R++ G
Sbjct: 1048 RSLVGLSQERAAELMTRTSS---VVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSG 1104
Query: 128 ---PPTKAVDL-----SHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLA 179
P ++ +L + P + P A G + + S P+
Sbjct: 1105 KPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQP 1164
Query: 180 PRPPGQDPAKKATRVSLQGRGENNELLKEIEP 211
P P G+ T + N +E P
Sbjct: 1165 PSPGGKSAYASGTTAKITSVSTGNLCTEEQTP 1196
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 53.9 bits (128), Expect = 1e-06
Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 28/136 (20%)
Query: 11 IQPNVISVRLFKRKVGGLGFLVKERVSKP------PVIISDLIRGGAAEQSGLIQAGDII 64
I V+ ++LFK G LGF + V + ++ +I GGAA++ G +Q GD +
Sbjct: 136 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 194
Query: 65 LAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQ 124
L VN L +++++ A+ +L+ + E + G P TI +T
Sbjct: 195 LMVNNYSLEEVTHEEAVAILKNTS-------------------EVVYLKVGKPTTIYMTD 235
Query: 125 PLGPPTKAVDLSHQPP 140
P GPP + S+ PP
Sbjct: 236 PYGPPD--ITHSYSPP 249
Score = 45.4 bits (106), Expect = 4e-04
Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 27 GLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRG 86
GLGF + + +S ++ GG A+ SG +Q GD IL+VNG L S++ A L+G
Sbjct: 327 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 386
Query: 87 IASETHVVLILRGPEGF 103
A +T ++ PE +
Sbjct: 387 -AGQTVTIIAQYQPEDY 402
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 53.9 bits (128), Expect = 1e-06
Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 28/136 (20%)
Query: 11 IQPNVISVRLFKRKVGGLGFLVKERVSKP------PVIISDLIRGGAAEQSGLIQAGDII 64
I V+ ++LFK G LGF + V + ++ +I GGAA++ G +Q GD +
Sbjct: 292 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 350
Query: 65 LAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQ 124
L VN L +++++ A+ +L+ + E + G P TI +T
Sbjct: 351 LMVNNYSLEEVTHEEAVAILKNTS-------------------EVVYLKVGKPTTIYMTD 391
Query: 125 PLGPPTKAVDLSHQPP 140
P GPP + S+ PP
Sbjct: 392 PYGPPD--ITHSYSPP 405
Score = 45.4 bits (106), Expect = 4e-04
Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 27 GLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRG 86
GLGF + + +S ++ GG A+ SG +Q GD IL+VNG L S++ A L+G
Sbjct: 535 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 594
Query: 87 IASETHVVLILRGPEGF 103
A +T ++ PE +
Sbjct: 595 -AGQTVTIIAQYQPEDY 610
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 53.9 bits (128), Expect = 1e-06
Identities = 38/136 (27%), Positives = 63/136 (46%), Gaps = 28/136 (20%)
Query: 11 IQPNVISVRLFKRKVGGLGFLVKERVSKP------PVIISDLIRGGAAEQSGLIQAGDII 64
I V+ ++LFK G LGF + V + ++ +I GGAA++ G +Q GD +
Sbjct: 187 ILETVVEIKLFKGPKG-LGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRL 245
Query: 65 LAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQ 124
L VN L +++++ A+ +L+ + E + G P TI +T
Sbjct: 246 LMVNNYSLEEVTHEEAVAILKNTS-------------------EVVYLKVGKPTTIYMTD 286
Query: 125 PLGPPTKAVDLSHQPP 140
P GPP + S+ PP
Sbjct: 287 PYGPPD--ITHSYSPP 300
Score = 45.4 bits (106), Expect = 4e-04
Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 1/77 (1%)
Query: 27 GLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRG 86
GLGF + + +S ++ GG A+ SG +Q GD IL+VNG L S++ A L+G
Sbjct: 430 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 489
Query: 87 IASETHVVLILRGPEGF 103
A +T ++ PE +
Sbjct: 490 -AGQTVTIIAQYQPEDY 505
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 53.9 bits (128), Expect = 1e-06
Identities = 40/97 (41%), Positives = 50/97 (51%), Gaps = 14/97 (14%)
Query: 22 KRKVGGLGF----LVKERVSKPPVIISDLIR------GGAAEQSGLIQAGDIILAVNGRP 71
K+ GLGF + KE S + SDL+R G AE++G I AGDIILAVNGR
Sbjct: 1061 KKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 1117
Query: 72 LVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLE 108
L + L +LRG E +L+ R P G LE
Sbjct: 1118 TEGLIFQEVLHLLRGAPQEV-TLLLCRPPPGALPELE 1153
Score = 38.1 bits (87), Expect = 0.061
Identities = 26/92 (28%), Positives = 49/92 (53%), Gaps = 6/92 (6%)
Query: 15 VISVRLFKRKVGGLGFLVKERV----SKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGR 70
++ V L + G GF++ E + P + IS +I GG AE++ I+ G ILA+N
Sbjct: 751 IVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHI 810
Query: 71 PLVDLSYDSALEVLRGIASETHVVLILRGPEG 102
L +++ A+ +++ S ++ LI+ +G
Sbjct: 811 SLEGFTFNMAVRMIQN--SPDNIELIISQSKG 840
Score = 36.6 bits (83), Expect = 0.18
Identities = 32/119 (26%), Positives = 50/119 (42%), Gaps = 5/119 (4%)
Query: 26 GGLGFLVKERVSKPP----VIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSAL 81
G LGF V ++ + + ++ GG A + G I GD +L V+G L L++ A+
Sbjct: 936 GTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAV 995
Query: 82 EVLRGIASETHVVLILRGPEGFTTHLETTFT-GDGTPKTIRVTQPLGPPTKAVDLSHQP 139
+ L G +VL R P + GD VT G P+ V ++ P
Sbjct: 996 QCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGP 1054
>gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo
sapiens]
Length = 320
Score = 53.9 bits (128), Expect = 1e-06
Identities = 40/97 (41%), Positives = 50/97 (51%), Gaps = 14/97 (14%)
Query: 22 KRKVGGLGF----LVKERVSKPPVIISDLIR------GGAAEQSGLIQAGDIILAVNGRP 71
K+ GLGF + KE S + SDL+R G AE++G I AGDIILAVNGR
Sbjct: 94 KKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 150
Query: 72 LVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLE 108
L + L +LRG E +L+ R P G LE
Sbjct: 151 TEGLIFQEVLHLLRGAPQEV-TLLLCRPPPGALPELE 186
>gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo
sapiens]
Length = 261
Score = 53.9 bits (128), Expect = 1e-06
Identities = 40/97 (41%), Positives = 50/97 (51%), Gaps = 14/97 (14%)
Query: 22 KRKVGGLGF----LVKERVSKPPVIISDLIR------GGAAEQSGLIQAGDIILAVNGRP 71
K+ GLGF + KE S + SDL+R G AE++G I AGDIILAVNGR
Sbjct: 35 KKNANGLGFSFVQMEKESCSH---LKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRS 91
Query: 72 LVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLE 108
L + L +LRG E +L+ R P G LE
Sbjct: 92 TEGLIFQEVLHLLRGAPQEV-TLLLCRPPPGALPELE 127
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,681,480
Number of Sequences: 37866
Number of extensions: 2987021
Number of successful extensions: 8460
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 105
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 7966
Number of HSP's gapped (non-prelim): 504
length of query: 1434
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1319
effective length of database: 13,892,928
effective search space: 18324772032
effective search space used: 18324772032
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.