Guide to the Human Genome
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Search of human proteins with 117414162

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|117414162 sodium channel associated protein 2 isoform a
[Homo sapiens]
         (1032 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|117414162 sodium channel associated protein 2 isoform a [Homo...  2022   0.0  
gi|117414154 sodium channel associated protein 2 isoform b [Homo...  1819   0.0  
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            115   2e-25
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    115   2e-25
gi|71061468 centromere protein E [Homo sapiens]                       111   3e-24
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   108   2e-23
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   108   3e-23
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   108   3e-23
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   108   3e-23
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   108   3e-23
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   108   3e-23
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   105   2e-22
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   105   3e-22
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    103   6e-22
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]   103   8e-22
gi|31542634 filamin A interacting protein 1 [Homo sapiens]            103   8e-22
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...   102   1e-21
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...   102   1e-21
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...   100   5e-21
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   100   5e-21
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr...   100   7e-21
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr...   100   7e-21
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   100   7e-21
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   100   7e-21
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...   100   9e-21
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...   100   9e-21
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    99   3e-20
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    98   4e-20
gi|148746195 trichohyalin [Homo sapiens]                               98   5e-20
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         97   6e-20

>gi|117414162 sodium channel associated protein 2 isoform a [Homo
            sapiens]
          Length = 1032

 Score = 2022 bits (5238), Expect = 0.0
 Identities = 1032/1032 (100%), Positives = 1032/1032 (100%)

Query: 1    MEAAAAVVAAEAEVENEDGDSSCGDVCFMDKGLQSISELSLDSTLHAVNLHCNNISKIEA 60
            MEAAAAVVAAEAEVENEDGDSSCGDVCFMDKGLQSISELSLDSTLHAVNLHCNNISKIEA
Sbjct: 1    MEAAAAVVAAEAEVENEDGDSSCGDVCFMDKGLQSISELSLDSTLHAVNLHCNNISKIEA 60

Query: 61   IDHIWNLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNH 120
            IDHIWNLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNH
Sbjct: 61   IDHIWNLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNH 120

Query: 121  IDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFLTNLILEKDGDDNPVCRL 180
            IDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFLTNLILEKDGDDNPVCRL
Sbjct: 121  IDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFLTNLILEKDGDDNPVCRL 180

Query: 181  PGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGLLDNLVSSDSPLNISEDE 240
            PGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGLLDNLVSSDSPLNISEDE
Sbjct: 181  PGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGLLDNLVSSDSPLNISEDE 240

Query: 241  IIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKL 300
            IIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKL
Sbjct: 241  IIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKL 300

Query: 301  DDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAKTI 360
            DDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAKTI
Sbjct: 301  DDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAKTI 360

Query: 361  QTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSHSED 420
            QTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSHSED
Sbjct: 361  QTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSHSED 420

Query: 421  NTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIF 480
            NTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIF
Sbjct: 421  NTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIF 480

Query: 481  RERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQA 540
            RERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQA
Sbjct: 481  RERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQA 540

Query: 541  AQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTD 600
            AQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTD
Sbjct: 541  AQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTD 600

Query: 601  ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG 660
            ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG
Sbjct: 601  ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG 660

Query: 661  FENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQ 720
            FENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQ
Sbjct: 661  FENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQ 720

Query: 721  INTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSL 780
            INTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSL
Sbjct: 721  INTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSL 780

Query: 781  AQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI 840
            AQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI
Sbjct: 781  AQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI 840

Query: 841  KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAY 900
            KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAY
Sbjct: 841  KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAY 900

Query: 901  STLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAF 960
            STLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAF
Sbjct: 901  STLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAF 960

Query: 961  KRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQ 1020
            KRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQ
Sbjct: 961  KRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQ 1020

Query: 1021 LAFALNEIQQDM 1032
            LAFALNEIQQDM
Sbjct: 1021 LAFALNEIQQDM 1032


>gi|117414154 sodium channel associated protein 2 isoform b [Homo
            sapiens]
          Length = 939

 Score = 1819 bits (4712), Expect = 0.0
 Identities = 929/929 (100%), Positives = 929/929 (100%)

Query: 104  GLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFL 163
            GLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFL
Sbjct: 11   GLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFL 70

Query: 164  TNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGL 223
            TNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGL
Sbjct: 71   TNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGL 130

Query: 224  LDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPE 283
            LDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPE
Sbjct: 131  LDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPE 190

Query: 284  KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKEC 343
            KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKEC
Sbjct: 191  KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKEC 250

Query: 344  NRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQES 403
            NRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQES
Sbjct: 251  NRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQES 310

Query: 404  EKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKED 463
            EKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKED
Sbjct: 311  EKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKED 370

Query: 464  IHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRT 523
            IHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRT
Sbjct: 371  IHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRT 430

Query: 524  LEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLAL 583
            LEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLAL
Sbjct: 431  LEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLAL 490

Query: 584  KEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEF 643
            KEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEF
Sbjct: 491  KEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEF 550

Query: 644  RIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKL 703
            RIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKL
Sbjct: 551  RIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKL 610

Query: 704  AEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLR 763
            AEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLR
Sbjct: 611  AEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLR 670

Query: 764  TERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQT 823
            TERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQT
Sbjct: 671  TERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQT 730

Query: 824  ETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLK 883
            ETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLK
Sbjct: 731  ETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLK 790

Query: 884  QQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSI 943
            QQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSI
Sbjct: 791  QQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSI 850

Query: 944  ELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMREL 1003
            ELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMREL
Sbjct: 851  ELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMREL 910

Query: 1004 LEETCKNKKTMEAKIKQLAFALNEIQQDM 1032
            LEETCKNKKTMEAKIKQLAFALNEIQQDM
Sbjct: 911  LEETCKNKKTMEAKIKQLAFALNEIQQDM 939


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  115 bits (288), Expect = 2e-25
 Identities = 154/751 (20%), Positives = 307/751 (40%), Gaps = 89/751 (11%)

Query: 296  KLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPY 355
            +LQKL   + +L  +     +N+L+K            E DY   +E      + ++   
Sbjct: 289  ELQKLKSSVNELTQKNQTLTENLLKK------------EQDYTKLEE------KHNEESV 330

Query: 356  DAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQ 415
              K IQ   H        +          L  ++V  S       + ++K K E+ +V+ 
Sbjct: 331  SKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG----EATQKLKEELSEVET 386

Query: 416  SHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR- 474
                   YQ L  +  Q +++R   EQ   +L   I++LH             LL T+R 
Sbjct: 387  K------YQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK-----------LLETERQ 429

Query: 475  LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ 534
            L E   R +  +      +   + ++  L ++L + ++Q ++ + +   L+  L+K ++Q
Sbjct: 430  LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ 489

Query: 535  KRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL-ALKEQEHRKELE 593
             ++QQA Q    Q    K   A  ++  +   +  + ++ Q L  LL   KE     E E
Sbjct: 490  HQEQQALQ----QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545

Query: 594  TREFFTD---ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVE 650
              + +      + + A+  ++ ++    ++ + +  EK+   S+ +   +      +  +
Sbjct: 546  REDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ 605

Query: 651  ARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLK 710
                +  +D   ++ T + +    L       NES   +  L   +K +   L      K
Sbjct: 606  KAHLRAAQDRVLSLETSVNELNSQL-------NESKEKVSQLDIQIKAKTELLLSAEAAK 658

Query: 711  QETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWG 770
                A+LQN ++T +  ++D +Q   ++  +  +  Q+ ++L  K+     L +  K   
Sbjct: 659  TAQRADLQNHLDTAQNALQDKQQ---ELNKITTQLDQVTAKLQDKQEHCSQLESHLK--- 712

Query: 771  HELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLK 830
             E  ++  SL Q   +LE QI+ L           E+DS  ++   +      +  R+L 
Sbjct: 713  -EYKEKYLSLEQKTEELEGQIKKL-----------EADSLEVKASKEQALQDLQQQRQLN 760

Query: 831  DCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQL---- 886
              L+ +   + +  E   EI   T+  L +KS  L+ + +KL +  E K+ LKQ      
Sbjct: 761  TDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820

Query: 887  KGKEVELEEIRKAYST----LNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKS 942
            +  +++ EE+     T    L +   +K  L+  L T VK+   K  +  K  K+E +K 
Sbjct: 821  QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST-VKDKLSKVSDSLKNSKSEFEKE 879

Query: 943  IELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRE 1002
             +  K A+  L       K Q+   +E    E      E +K ++      HQ++ E+  
Sbjct: 880  NQKGKAAILDLEKTCKELKHQLQVQMENTLKE----QKELKKSLEKEKEASHQLKLELNS 935

Query: 1003 LLEETCKNKKTM---EAKIKQLAFALNEIQQ 1030
            + E+  + + T+   E + +QL   +NE++Q
Sbjct: 936  MQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966



 Score =  106 bits (264), Expect = 1e-22
 Identities = 160/812 (19%), Positives = 347/812 (42%), Gaps = 79/812 (9%)

Query: 279  SSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYG 338
            SSE   +  +     ++KL +L++Q+ + +   S  + + L+K  +  ++     +S   
Sbjct: 444  SSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN-STELQHQLDKTKQQHQEQQALQQSTTA 502

Query: 339  NRKECNRKVPRRSKIPYDA----KTIQTIKHHNKNYNSFVSCNR-----KMKPPYLKELY 389
              +E    + +  +   D     + ++ +   +K   S +   R     K++    +   
Sbjct: 503  KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562

Query: 390  VSSSLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMD 449
            ++        LQE     TE +K +QS S     ++L +Q+ +++     A+     L  
Sbjct: 563  LNQLQEKNHTLQEQVTQLTEKLK-NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621

Query: 450  YIDELHKHANE-KEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKL----------QN 498
             ++EL+   NE KE +  L +    + + ++  E     Q   + + L          Q 
Sbjct: 622  SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681

Query: 499  EIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMER------QKRQQQAAQIRLIQEVELK 552
            E+ K+T +L +   + +D  +H   LE  L++ +       QK ++   QI+ ++   L+
Sbjct: 682  ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741

Query: 553  ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIA 612
              A+  +         ++ +Q +QL+  L L+  E  K+LE  +    +   D   K  A
Sbjct: 742  VKASKEQAL-------QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794

Query: 613  KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIA-------LTVEARRFQDVKDGFENVA 665
             E  K  Q + + +E+  +L Q +  L  E +I        +       Q VK   E + 
Sbjct: 795  LESIK--QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852

Query: 666  TELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINT-L 724
            TEL+  K  L         S SL    +   KE +   A +  L ++T   L++Q+   +
Sbjct: 853  TELSTVKDKL------SKVSDSLKNSKSEFEKENQKGKAAILDL-EKTCKELKHQLQVQM 905

Query: 725  EILIEDDKQKSIQIELLKHEKVQLISEL-AAKESLIFGLRTERKVWGHELAQQGS--SLA 781
            E  +++ K+    +E  K    QL  EL + +E LI    T ++    E   QG+   L 
Sbjct: 906  ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965

Query: 782  QNRGKLEAQIESLSRE------------NECLRKTNESDSDALRIKCKI------IDDQT 823
            Q+  + + QIE+L  E            N+  ++  ++  +    K KI       +   
Sbjct: 966  QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ 1025

Query: 824  ETIRKLKDCLQEKDEHIKRLQEKITEIEK---CTQEQLDEKSSQLDEVLEKLERHNERKE 880
            ET ++L+     ++  +   ++ +  +E+     QE L    +Q+    + ++     K 
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085

Query: 881  KLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERD 940
             L+Q    KE +L+E  KA   + ++   K + L + ++++ E++E    +EK++    +
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145

Query: 941  KSIELQKNAMEKLHSMDDAFKRQVDAIVEAH-QAEIAQLANEKQKCIDSANLKVHQIEKE 999
            +    +  +++++ ++ DA +  +   +E   +A+  + A E++K   +  +   Q++KE
Sbjct: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK--RNQQILKDQVKKE 1203

Query: 1000 MRELLEETCKNKKTMEAKIKQLAFALNEIQQD 1031
              EL +E  + +  + ++IK+    + + +++
Sbjct: 1204 EEELKKEFIEKEAKLHSEIKEKEVGMKKHEEN 1235



 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 150/711 (21%), Positives = 300/711 (42%), Gaps = 105/711 (14%)

Query: 388  LYVSSSLANCPMLQESEKPKTEIIKVDQSHS--EDNTYQSLVEQLDQER---EKRWRAEQ 442
            L   SS     + Q+ E+ +TE   + Q     E    Q   E  D +    E+R   E 
Sbjct: 129  LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188

Query: 443  AENKLMDYIDELHKHANEKED----------IHSLALL--------------------TT 472
            AE K+    +EL+K A   +D          I  +A+L                     +
Sbjct: 189  AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248

Query: 473  DRLKEIIFRERNSKGQLEVMVHKLQNEIKK-------LTVELMKAKDQQEDHLKHLRTLE 525
            ++LK+   + ++     E  + +L++E+ K          EL K K    +  +  +TL 
Sbjct: 249  EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308

Query: 526  KTLEKMER------QKRQQQAAQIRLI-----------QEVELKASAADREIYLLRTSLH 568
            + L K E+      +K  +++   + I           Q+++ + SA++  ++ +   L 
Sbjct: 309  ENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELS 368

Query: 569  REREQAQQLHQLLALKE-------------QEHRKELETREFFTDADFQDALAKEIAKEE 615
             + E  Q+L + L+  E             Q+ R+E E       ++  + L  ++ + E
Sbjct: 369  EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI-NQLHSKLLETE 427

Query: 616  KKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHAL 675
            ++  +     +E+  + S++ MD E +        +R  + +K+   N +TEL   +H L
Sbjct: 428  RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN-STEL---QHQL 483

Query: 676  IWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKS 735
               +++  E  +L +  T  ++E +  L +V +   +    +QN    LE L++  K+  
Sbjct: 484  DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN----LEALLQKSKE-- 537

Query: 736  IQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLS 795
              I LL+ E+  L +++ A E     +  + +   H L +Q + L +   KL+ Q ES  
Sbjct: 538  -NISLLEKEREDLYAKIQAGEGET-AVLNQLQEKNHTLQEQVTQLTE---KLKNQSESHK 592

Query: 796  RENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQ 855
            +  E L    +     LR     +     ++ +L   L E  E + +L  +I    K   
Sbjct: 593  QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI----KAKT 648

Query: 856  EQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLC 915
            E L   S++  +  ++ +  N   +  +  L+ K+ EL +I      +  K  DK E   
Sbjct: 649  ELL--LSAEAAKTAQRADLQN-HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705

Query: 916  HLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAF-----KRQVDAIVEA 970
             LE+ +KE KEK+ + E+K +    +  +L+ +++E   S + A      +RQ++  +E 
Sbjct: 706  QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765

Query: 971  HQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 1021
               E+++    +++ + S  L    ++K+   L  E+ K K T + + KQ+
Sbjct: 766  RATELSKQLEMEKEIVSSTRL---DLQKKSEAL--ESIKQKLTKQEEEKQI 811



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 157/786 (19%), Positives = 327/786 (41%), Gaps = 103/786 (13%)

Query: 213  NSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTS 272
            + S  Q  E L D +    + L  ++D ++     +     +L   ++  S   D  + +
Sbjct: 588  SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ-LDIQIKA 646

Query: 273  FMSVCQSSEPEKNNHENDLQNEIKLQK--LDDQILQLLNETSNSIDNVLEKDPRPKRDTD 330
               +  S+E  K     DLQN +   +  L D+  Q LN+ +  +D V  K  + K++  
Sbjct: 647  KTELLLSAEAAKTAQRADLQNHLDTAQNALQDK-QQELNKITTQLDQVTAK-LQDKQEHC 704

Query: 331  ITSESDYGNRKECNRKVPRRS--------KIPYDAKTIQTIKHH---NKNYNSFVSCNRK 379
               ES     KE    + +++        K+  D+  ++  K     +      ++ + +
Sbjct: 705  SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLE 764

Query: 380  MKPPYL-KELYVSSSLANCPML---QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQERE 435
            ++   L K+L +   + +   L   ++SE  ++   K+ +   E    +   E L QE  
Sbjct: 765  LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET- 823

Query: 436  KRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHK 495
             + + E+  N++   + EL K   EKE + +      D+L ++    +NSK + E    K
Sbjct: 824  -KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882

Query: 496  LQNEIKKLTVELMKAKDQ----QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVEL 551
             +  I  L     + K Q     E+ LK  + L+K+LEK E++   Q   ++  +QE  +
Sbjct: 883  GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK-EKEASHQLKLELNSMQEQLI 941

Query: 552  KASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEI 611
            +A           T    E+E+ Q    +  LK+   +K+ +        + + A+ ++ 
Sbjct: 942  QAQ---------NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL--QGELKIAVLQKT 990

Query: 612  AKEEKKHEQMIKEYQE------KIDVLSQQY-------MDLENEFRIALTVEARRFQDVK 658
              E K  +Q+ +  QE      KI VL   Y         L+++F    +      QD+K
Sbjct: 991  ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050

Query: 659  D-------------------GFENVATELAKSKHALIW--AQRKENESSSLIKDLTCMVK 697
                                G +N   +  K+  A +   + +KE +     K L  + K
Sbjct: 1051 SVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQK 1110

Query: 698  E----------QKTKLAEVSKLK-----QETAANLQNQINTLEILIEDDKQKSIQIELLK 742
            E          +K+KLAE+ ++K     + T  N + + + LE + E    K  + +LL 
Sbjct: 1111 EKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAK-QLLI 1169

Query: 743  HEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR 802
             +K++L  +  + ++ +   +  +++   ++ ++   L +   + EA++ S  +E E   
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGM 1229

Query: 803  KTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKR----LQEKITEIEKCTQEQL 858
            K +E +   L ++   +++   T++K     Q +   +++    L+ +I  +E   Q   
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQ 1289

Query: 859  DEKSSQLDEVLE---KLERHNERKEKLKQQLKGKEVELEEIR--------KAYSTLNRKW 907
            DE+ + L+  L+   ++E+   +  +L+++L      ++E+         K    LNRKW
Sbjct: 1290 DERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKW 1349

Query: 908  HDKGEL 913
             +  E+
Sbjct: 1350 AEDNEV 1355


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  115 bits (288), Expect = 2e-25
 Identities = 192/837 (22%), Positives = 351/837 (41%), Gaps = 148/837 (17%)

Query: 288  ENDLQNEIK--LQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNR 345
            E + Q ++K  L+K   + L++  E        LE+    K+   I +ES+   R     
Sbjct: 504  EREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA--ILTESENKLRDLQQE 561

Query: 346  KVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKM-KPPYLKELYVSSSLANCPMLQESE 404
                R++I     +++     NKN +  ++ + +  K  + KE+ V         + E  
Sbjct: 562  AETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV---------MVEKH 612

Query: 405  KPKTEIIKVDQSHSEDNTYQSLVEQLDQEREK-RWRAEQAENKLMD--------YIDELH 455
            K + E +K  Q        Q L +Q   E EK R + EQ +  L+         +I+E++
Sbjct: 613  KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 672

Query: 456  KHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQE 515
            +   EK D+    L +       + + R          HKL+ E+  L  +  K K + E
Sbjct: 673  EKTLEKLDVKQTELESLSSELSEVLKAR----------HKLEEELSVLKDQTDKMKQELE 722

Query: 516  DHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQ 575
                          KM+ QK   Q     +I+E E+     ++ +          ++Q  
Sbjct: 723  -------------AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL----------KDQIN 759

Query: 576  QLHQLLA-----LKE-QEHRKELETREFFTDADFQDALAKEI---AKEEKKHEQMIKEYQ 626
            QL  LL      LKE Q H + LE     ++ + Q A AK     + +   HEQ  K Y+
Sbjct: 760  QLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT-KAYE 818

Query: 627  EKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK-HALIWAQRKENES 685
            E++  L Q+ +DLE E RI LT +    +  K   ++V TEL   K       Q+ E ++
Sbjct: 819  EQLAQLQQKLLDLETE-RILLTKQVAEVEAQK---KDVCTELDAHKIQVQDLMQQLEKQN 874

Query: 686  SSLIKDLTCMVKEQKTKLAEVSKLKQETAANL-----------QNQINTLEILIEDDKQK 734
            S + + +  + +  ++KL + +K +++T   L           + Q   +EIL +    K
Sbjct: 875  SEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK 934

Query: 735  SIQIELLKHE----------KVQLISELAAK--ESLIFGLRTERKVWGHELAQQGSSLAQ 782
               I +L  E          K++ + + A +  E+L   L  +      EL      L+Q
Sbjct: 935  EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQ 994

Query: 783  NRGKLEAQIESLSRENEC-------LRKTNESD-------------SDALRIKCKIIDDQ 822
               +  A++  +++ N           +TN+ +             +D + I  K ++ Q
Sbjct: 995  KEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQ 1054

Query: 823  TETIRKLKDC-LQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQL-------DEVLEKLER 874
             E ++++ +  LQEK++ +  L++KI  +  C +E+++++ + L       D  L +L+ 
Sbjct: 1055 AEELQEIHEIQLQEKEQEVAELKQKIL-LFGCEKEEMNKEITWLKEEGVKQDTTLNELQE 1113

Query: 875  HNERKE-----------KLKQQLKGKEVELEEIRKAYSTLNRKW--------HDK---GE 912
              ++K            KLK  L+  EV+L +  K  + L  +          DK    E
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSE 1173

Query: 913  LLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQ 972
            L   L+T  +E +    + EK  K+  DKS+E +K + E    +D   K+  +A++EA  
Sbjct: 1174 LTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKK-TEALLEAKT 1232

Query: 973  AEIAQLANEKQKCIDSANLKV-HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEI 1028
             E+  +++ K   I S      H+  K    LL +TC   + +EA+++QL    N +
Sbjct: 1233 NELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE-LEAQLRQLTEEQNTL 1288



 Score =  110 bits (275), Expect = 7e-24
 Identities = 157/676 (23%), Positives = 308/676 (45%), Gaps = 72/676 (10%)

Query: 401  QESEKPKTEIIKVDQSH----SEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHK 456
            +E EK  +   K +++     +E +     +E+  +E     + E +  K  + +D + K
Sbjct: 414  EELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK-QEVVDVMKK 472

Query: 457  HANEK----EDIHS--LALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKA 510
             + E+    + +H   LA    +  K++  RER  + Q++V + K Q+E  K++ E    
Sbjct: 473  SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE---- 528

Query: 511  KDQQED------HLKHLRTLEKTLEKMERQKRQQQAAQIRLIQ-EVELKASAADREIYLL 563
            K+QQE        L+    L ++  K+   +++ +  + R+++ E  L+ S  + +    
Sbjct: 529  KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588

Query: 564  RTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALA-------KEIAKEEK 616
              ++H E E+ +   ++  + E+ H+ ELE+ +   DA + + L         E+ K  +
Sbjct: 589  DLAVHLEAEKNKHNKEITVMVEK-HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE 647

Query: 617  KHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG-FENVATELAKSKHAL 675
            K EQ  +   +  +++ Q +++  NE     T+E     DVK    E++++EL++    +
Sbjct: 648  KCEQEKETLLKDKEIIFQAHIEEMNE----KTLEKL---DVKQTELESLSSELSE----V 696

Query: 676  IWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDD---- 731
            + A+ K  E  S++KD T  +K++    A++ + K      + + I   E+ I+      
Sbjct: 697  LKARHKLEEELSVLKDQTDKMKQELE--AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL 754

Query: 732  KQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQI 791
            K +  Q+ELL  E+ + + E  A    +  L  + K    EL Q  + L   +    A  
Sbjct: 755  KDQINQLELLLKERDKHLKEHQAH---VENLEADIKRSEGELQQASAKLDVFQSYQSATH 811

Query: 792  ESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIE 851
            E      E L +  +   D    +  +     E   + KD   E D H  ++Q+ + ++E
Sbjct: 812  EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 871

Query: 852  KCTQEQLDEKSSQLDEVLE-KLERHNERKEKLKQQLKGKEVELEEIR----KAYSTLNRK 906
            K   E +++K   L +V E KLE  N+ +E+ KQ L  KE  + ++R    K    L +K
Sbjct: 872  KQNSE-MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQK 930

Query: 907  WHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVD- 965
               K + +  L    +E + KF+N+EKK++  + K+ E+Q+   +KL   +   K++++ 
Sbjct: 931  LSAKEDSIHILN---EEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELEN 987

Query: 966  AIVEAHQ------AEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNK-----KTM 1014
              +E  Q      A++ ++A      I  A  ++   +KE  E L E  + +        
Sbjct: 988  TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW 1047

Query: 1015 EAKIKQLAFALNEIQQ 1030
            E K+ Q A  L EI +
Sbjct: 1048 EKKLNQQAEELQEIHE 1063



 Score =  104 bits (260), Expect = 4e-22
 Identities = 151/735 (20%), Positives = 320/735 (43%), Gaps = 133/735 (18%)

Query: 398  PMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKH 457
            P++++    KT      +   ++N  +   E +   +E+       +  L + +DE  + 
Sbjct: 270  PVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQE 329

Query: 458  ANEKEDIH---SLALLTTDR-LKEIIFRERNSKGQL---------------EVMVHKLQN 498
              + +D+H      L+T  R  K +I +    KG +               E  + +L++
Sbjct: 330  LEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS 389

Query: 499  EIKKLTVELMKAKDQQ--------EDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQE-- 548
             IK++T +  + ++Q+        E+  K L T +KT E+  R+ + +   QI+ I++  
Sbjct: 390  RIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKT-EEARRKLKAEMDEQIKTIEKTS 448

Query: 549  ------VELKASAADREIY-LLRTSLHREREQAQQLHQL-LALKEQEHRKELETREFFTD 600
                  ++ + S   +E+  +++ S   +  + Q+LH+  LA KEQE  K+L+TRE    
Sbjct: 449  EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRE---- 504

Query: 601  ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG 660
             +FQ+ +   +   EK   + +K  QEK    S    +LE + +  LT    + +D++  
Sbjct: 505  REFQEQMKVAL---EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQE 561

Query: 661  FENVATELAKSKHALIWA-QRKENESSSLI-----------KDLTCMVKEQKTKL----- 703
             E   T + + + +L  + Q  +N+S  L            K++T MV++ KT+L     
Sbjct: 562  AETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 621

Query: 704  ------------------AEVSKLKQETAANLQNQINTLEIL----IEDDKQKSIQ-IEL 740
                               E+ KL+++     +  +   EI+    IE+  +K+++ +++
Sbjct: 622  QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDV 681

Query: 741  LKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLA----QNRGKLEAQIESLSR 796
             + E   L SEL+        L  E  V   +  +    L     + +   + Q++S+ +
Sbjct: 682  KQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIK 741

Query: 797  ENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIE---KC 853
            E+E   +  E          K + DQ   I +L+  L+E+D+H+K  Q  +  +E   K 
Sbjct: 742  EHEVSIQRTE----------KALKDQ---INQLELLLKERDKHLKEHQAHVENLEADIKR 788

Query: 854  TQEQLDEKSSQLD-------EVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 906
            ++ +L + S++LD          E+ + + E+  +L+Q+L   E E   + K  + +  +
Sbjct: 789  SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848

Query: 907  WHDK-GELLCH-----------------LETQVKEVKEKFENKEKKLKAERDKSIELQKN 948
              D   EL  H                 +E +VK + + +E+K +    E++++ ++   
Sbjct: 849  KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE 908

Query: 949  AMEKLHSMDDAFKRQVDAIVE---AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLE 1005
                +  M +  K++++ + +   A +  I  L  E +    +   K+ +++++ +E+ E
Sbjct: 909  KENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQE 968

Query: 1006 ETCKNKKTMEAKIKQ 1020
               K     EAK+K+
Sbjct: 969  TLKKKLLDQEAKLKK 983



 Score =  100 bits (249), Expect = 7e-21
 Identities = 192/861 (22%), Positives = 357/861 (41%), Gaps = 138/861 (16%)

Query: 247  VITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQN-----EIKLQ--- 298
            ++T  + E+   ++   T  DA       + Q  E + +  E  +++     E KL+   
Sbjct: 837  LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN 896

Query: 299  KLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAK 358
            K  +Q  Q+L E  N I   L+     K++ +I ++                 K+     
Sbjct: 897  KEQEQTKQILVEKENMI---LQMREGQKKEIEILTQ-----------------KLSAKED 936

Query: 359  TIQTIKHHNKNYNS-FVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSH 417
            +I  +   N+ Y + F +  +KM+    K   +  +L    +L +  K K E+       
Sbjct: 937  SIHIL---NEEYETKFKNQEKKMEKVKQKAKEMQETLKK-KLLDQEAKLKKEL------- 985

Query: 418  SEDNTYQSLVEQLDQEREKRWRAEQAENK-LMDYIDELHKHANEKEDIHSLALLTTDRLK 476
              +NT   L ++  Q   K     QA +  + D +  L    N+KE I SL  +    L 
Sbjct: 986  --ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLE--TNQKEQIESLTEVHRRELN 1041

Query: 477  EIIF---RERNSKGQLEVMVHKLQNEIKKLTVELMKAKD-----QQEDHLKHLRTLEK-- 526
            ++I    ++ N + +    +H++Q + K+  V  +K K      ++E+  K +  L++  
Sbjct: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101

Query: 527  -----TLEKMERQKRQQQAAQIRLIQ-EVELKASAADREIYLLRTSLHREREQAQQLHQL 580
                 TL +++ Q +Q+ A    L Q E +LKA     E+ L + SL       +QL +L
Sbjct: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNK-SLKENTFLQEQLVEL 1160

Query: 581  LALKEQEHRK--ELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMD 638
              L E++ RK  EL ++   TD +FQ          +  HE+  K  ++K    S ++  
Sbjct: 1161 KMLAEEDKRKVSELTSKLKTTDEEFQSL--------KSSHEKSNKSLEDK----SLEFKK 1208

Query: 639  LENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWA-----QRKENESSSLIKDLT 693
            L  E  I L +  ++ + + +   N    ++ SK   I +     Q +  +    +   T
Sbjct: 1209 LSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1268

Query: 694  CMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISE-- 751
            C V E + +L ++++ +     + Q   + LE      K     IE L  EK  L  E  
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGG 1328

Query: 752  -----LAAKESLIFGLRTERK-------VWGHELAQQG---SSLAQNRGKLEAQIE---S 793
                  + KES I  L+ E         +   EL ++    SSL++    L  Q++   S
Sbjct: 1329 NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS 1388

Query: 794  LSRENECLRKTNESDSDALRIKCKIIDD------QTETIRKLK-DCLQEKD-------EH 839
            LS +   +    +   +    KC+++D       + +T+ K K   L++ D       E 
Sbjct: 1389 LSEKEAAISSLRKQYDEE---KCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445

Query: 840  IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQ------LKGK-EVE 892
             K+ Q + T+ +   +E   +   +  E  EK E+ N  KE+L QQ      LKG+ E +
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505

Query: 893  LEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKA-ERDKSIELQKNAME 951
              ++ K  S L  +   +   +  LE  + +   + E+  + LK   + K IE  K  ++
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE-HKELVQ 1564

Query: 952  KLHSMDDAFKRQVDAIVEAHQAEIAQLANE----------KQKCIDSANLKVHQIEKEMR 1001
            KL    +  + + + + EA + +I  L N+          K+K ++  NL V   E+E++
Sbjct: 1565 KLQHFQELGEEKDNRVKEAEE-KILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623

Query: 1002 ELLEETCKNKKTMEAKIKQLA 1022
             L +          A++K+ A
Sbjct: 1624 ALEDRLESESAAKLAELKRKA 1644



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 171/798 (21%), Positives = 323/798 (40%), Gaps = 153/798 (19%)

Query: 293  NEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSK 352
            NE  L+KLD +  +L    S+ +  VL+   R K + +++   D  ++           K
Sbjct: 672  NEKTLEKLDVKQTEL-ESLSSELSEVLKA--RHKLEEELSVLKDQTDKM----------K 718

Query: 353  IPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIK 412
               +AK  +   HH +  +S +           KE  VS        L++       ++K
Sbjct: 719  QELEAKMDEQKNHHQQQVDSII-----------KEHEVSIQRTE-KALKDQINQLELLLK 766

Query: 413  VDQSHSEDNTYQSLVEQLDQE-REKRWRAEQAENKL---MDYIDELHKHANEKE------ 462
                H ++  +Q+ VE L+ + +      +QA  KL     Y    H+     E      
Sbjct: 767  ERDKHLKE--HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL 824

Query: 463  -----DIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDH 517
                 D+ +  +L T ++ E+  ++++   +L+   HK+Q  ++ L  +L K   + E  
Sbjct: 825  QQKLLDLETERILLTKQVAEVEAQKKDVCTELDA--HKIQ--VQDLMQQLEKQNSEMEQK 880

Query: 518  LKHL-RTLEKTLEKMERQKRQQQAAQIRLIQE-------------VEL---KASAADREI 560
            +K L +  E  LE  +  K Q+Q  QI + +E             +E+   K SA +  I
Sbjct: 881  VKSLTQVYESKLE--DGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938

Query: 561  YLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDAL---AKEIAKEEKK 617
            ++L      + +  ++  + +  K +E ++ L+ +    +A  +  L   A E++++EK+
Sbjct: 939  HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998

Query: 618  HEQMIKEYQEK-----IDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK 672
                + E  +       D +S+   + + +      V  R   DV   +E    + A+  
Sbjct: 999  FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058

Query: 673  HAL--IWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIED 730
              +  I  Q KE E + L + +     E++    E++ LK+E       Q  TL  L E 
Sbjct: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGV----KQDTTLNELQEQ 1114

Query: 731  DKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQ 790
             KQKS  +  L  ++ +L + L   E                      SL +N    E  
Sbjct: 1115 LKQKSAHVNSLAQDETKLKAHLEKLE-----------------VDLNKSLKENTFLQEQL 1157

Query: 791  IESLSRENECLRKTNESDSDALRIKCKIIDDQTETIR----KLKDCLQEKDEHIKRLQEK 846
            +E      E  RK +E  S     K K  D++ ++++    K    L++K    K+L E+
Sbjct: 1158 VELKMLAEEDKRKVSELTS-----KLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1212

Query: 847  I----------TE--IEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELE 894
            +          TE  +E  T E ++  SS+ + +L ++     R  K+K+ L  K   + 
Sbjct: 1213 LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS 1272

Query: 895  EIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLH 954
            E+    + L +   ++  L    +    +++EK EN+ K +KA+ + S+  +K A++K  
Sbjct: 1273 ELE---AQLRQLTEEQNTLNISFQQATHQLEEK-ENQIKSMKADIE-SLVTEKEALQK-- 1325

Query: 955  SMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRE------LLEETC 1008
                                  Q A+EK+ CI        Q++KE+ E      L++E  
Sbjct: 1326 ----------------EGGNQQQAASEKESCIT-------QLKKELSENINAVTLMKEEL 1362

Query: 1009 KNKKTMEAKIKQLAFALN 1026
            K KK   + + +    LN
Sbjct: 1363 KEKKVEISSLSKQLTDLN 1380



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 173/879 (19%), Positives = 353/879 (40%), Gaps = 128/879 (14%)

Query: 208  NLTEINSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLE-----QFA 262
            N  +  S +  C+  L   L  + + + + ++E+ ++   I++   +L  L        +
Sbjct: 1329 NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS 1388

Query: 263  STPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKD 322
             +  +A ++S        + E  +   DL    K+  L  + +  L +    +D+   K 
Sbjct: 1389 LSEKEAAISSLRKQYDEEKCELLDQVQDLS--FKVDTLSKEKISALEQ----VDDWSNKF 1442

Query: 323  PRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDA-KTIQTIKHHNKNYNSFVSC----- 376
               K+             KE   ++  +SK  Y+  + I  +K      N    C     
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502

Query: 377  ----NRKMKPPYLKELYVSSSLANCPMLQESEKPKT-------EIIKVDQSHSEDNTYQS 425
                ++  K     E  + S  A    L++    KT       E++K + +  +D  ++ 
Sbjct: 1503 EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK-NYNQQKDIEHKE 1561

Query: 426  LVEQLD--QE--REKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFR 481
            LV++L   QE   EK  R ++AE K++   ++++    E E            L+ +   
Sbjct: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET-------KKKELEHVNLS 1614

Query: 482  ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAA 541
             ++ + +L+ +  +L++E      EL +  +Q+   +K     ++ L +ME ++ Q +  
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK-----KQLLSQMEEKEEQYKKG 1669

Query: 542  QIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDA 601
                + E+  K    +RE+++L   L  +  ++ Q   L+  +  ++      +E   +A
Sbjct: 1670 TESHLSELNTKLQEREREVHILEEKL--KSVESSQSETLIVPRSAKNVAAYTEQE---EA 1724

Query: 602  DFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGF 661
            D Q  + K               Y+EKI VL +   + E   ++   V   + + V   F
Sbjct: 1725 DSQGCVQKT--------------YEEKISVLQRNLTEKE---KLLQRVGQEKEETVSSHF 1767

Query: 662  E---NVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTK--LAEVSKLKQETAAN 716
            E        L K +HA    + K++E  S+I  L   ++E+  K  L     +++E   N
Sbjct: 1768 EMRCQYQERLIKLEHA----EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKN 1823

Query: 717  LQNQINTLEILIEDDKQKSIQIELLKHEKV-QLISELAAKESLIFGLRTERKVWGHELAQ 775
                   LE +  DD QK++Q + L  + + Q I EL   +S +   +   +V   EL  
Sbjct: 1824 NIQAKQNLENVF-DDVQKTLQEKELTCQILEQKIKEL---DSCLVRQKEVHRVEMEELTS 1879

Query: 776  QGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQE 835
            +   L   +     Q++  ++  E L +  E  S +  ++ K++ +       L+  L  
Sbjct: 1880 KYEKLQALQ-----QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934

Query: 836  KDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQ----------- 884
             +   ++L ++I  ++K  +    E   +L E+L+K E   ER+EK+KQ           
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQQEL-EILKK-EYDQEREEKIKQEQEDLELKHNS 1992

Query: 885  -----------QLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 933
                       QL  KE ELE   K   T+N+    + ELL   + +  ++ +K   K+ 
Sbjct: 1993 TLKQLMREFNTQLAQKEQELEMTIK--ETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050

Query: 934  KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLAN------------- 980
             LK    +  E+     E++ +     + Q++ + + +Q ++ Q  N             
Sbjct: 2051 DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQT 2110

Query: 981  ---EKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEA 1016
               +K   I  + LK  +  +++  L +   K +K + A
Sbjct: 2111 QLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYA 2149



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 88/455 (19%), Positives = 194/455 (42%), Gaps = 32/455 (7%)

Query: 605  DALAKE-IAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFR----IALTVEARRFQDVKD 659
            D+L KE + +  ++ E+ +  Y+ K   L   Y  L+ E +    I    + +  + + +
Sbjct: 132  DSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAE 191

Query: 660  GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAE----VSKLKQETAA 715
              E +  +    KH          E    I  L   V   K +L      V  LK     
Sbjct: 192  LREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQL 251

Query: 716  NLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQ 775
              Q ++ T E   E D +  ++          L   +  +E+L+   R +  +  H+  +
Sbjct: 252  EPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLL--KRCKETIQSHK--E 307

Query: 776  QGSSLAQNRGKLEAQIESLSRENECLRKTNESDS--------DALRIKCKIIDDQ----T 823
            Q + L   +  L+ Q++   +E E ++  + ++         DA  +  ++  D+     
Sbjct: 308  QCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIA 367

Query: 824  ETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLK 883
            ET R++ + L+ K+E I +L+ +I ++    +E  ++K        E+LE+     +K +
Sbjct: 368  ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTE 427

Query: 884  QQLKGKEVEL-EEIRKAYSTLNRKWHDKGELLCHLETQVKEV-KEKFENKEKKLKAERDK 941
            +  +  + E+ E+I+    T   +     + L  ++ +V +V K+  E +  KL+   +K
Sbjct: 428  EARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK 487

Query: 942  SIELQKNAM-EKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQK----CIDSANLKVHQI 996
             +  ++  + +KL + +  F+ Q+   +E  Q+E  +++ EK++     ++   L+   I
Sbjct: 488  ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI 547

Query: 997  EKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQD 1031
              E    L +  +  +T   +I +L  +L +  Q+
Sbjct: 548  LTESENKLRDLQQEAETYRTRILELESSLEKSLQE 582


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  111 bits (278), Expect = 3e-24
 Identities = 169/848 (19%), Positives = 352/848 (41%), Gaps = 122/848 (14%)

Query: 274  MSVCQSSEPEKNNHENDLQN-EIKLQKLDDQILQLLNETSNSIDNV--LEKDPRPKRDTD 330
            MS  Q    E  N +N+L+N E+ L+ ++ + L+L  + + + + V  + K+ +  ++  
Sbjct: 1150 MSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ 1209

Query: 331  ITSESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYV 390
             + E++  + +   R++        +   I  I  H K +   +   R+       ++  
Sbjct: 1210 KSFETERDHLRGYIREIEATGLQTKEELKIAHI--HLKEHQETIDELRRSVSEKTAQIIN 1267

Query: 391  SSSLANC--------PMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQ--------LDQER 434
            +  L           P+L E ++    + +V ++    N  + L EQ        L +  
Sbjct: 1268 TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIE 1327

Query: 435  EKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEII------FRERNSKGQ 488
             +R R  +   +  + I  L K  +  + I     +  D+LKE I       +E  SK +
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387

Query: 489  LEVMVHKLQNEIKKLTVEL--MKAKDQ----------------QEDHLKHLRTLEKTLEK 530
              + + +  NE  K+  E+   K KD                 QE H   ++++ K  + 
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH-DEMKSVAKEKDD 1446

Query: 531  MERQKRQQQAAQIRL---IQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQE 587
            ++R +   Q+   +L   I+E+  K    + E+ +    L  + E   +L   L+ KE E
Sbjct: 1447 LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506

Query: 588  HRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ------------- 634
                 +  E   D   Q+ + +   KEE+ + + I E QEK++ L Q             
Sbjct: 1507 ISTIQKQLEAINDK-LQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQ 1565

Query: 635  ----QYMDLENEFRIA------LTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENE 684
                + ++L N  + +      +  E    + V++  +    +L ++   ++   ++  E
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE 1625

Query: 685  SSSLIKDLTCMVKEQKTKLAEVSKLKQETAA---NLQN----QINTLEILIED------- 730
                   +T  V E + K+ E+  LK++      NL+N     I   +IL E+       
Sbjct: 1626 KEYQFLKMTA-VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684

Query: 731  ----DKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGK 786
                D  +S++ E LK E+ QL   L    +     + E K+    L +   ++ + RG 
Sbjct: 1685 TKERDDLRSVE-ETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGI 1743

Query: 787  LEAQIESLSR-------ENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEH 839
            +  +   +S         N+ L+  +    + LRI    + +Q ETI KL+  + EK + 
Sbjct: 1744 VSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDK 1803

Query: 840  IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERK------EKLKQQLKGKEVEL 893
            +  +Q+ +       QE++ E  +   +++   +  NE +      E+LK+Q+K + + L
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTL 1863

Query: 894  EEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKL 953
             ++      L +K H+  E    +++ +KE ++     E+ LK ERD+  E         
Sbjct: 1864 SKLEIENLNLAQKLHENLE---EMKSVMKE-RDNLRRVEETLKLERDQLKE--------- 1910

Query: 954  HSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKT 1013
             S+ +   R ++   E   A +  L+ E ++ +D    K+ +   ++ ++ ++  K+K  
Sbjct: 1911 -SLQETKARDLEIQQELKTARM--LSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1967

Query: 1014 MEAKIKQL 1021
            ++ KI++L
Sbjct: 1968 LQKKIQEL 1975



 Score =  109 bits (272), Expect = 2e-23
 Identities = 216/1065 (20%), Positives = 447/1065 (41%), Gaps = 151/1065 (14%)

Query: 35   SISELSLDSTLHAVNL-----------HCNNISKIEAIDHIWNLQHLDLSSN--QISRIE 81
            +I+ +S D TL A+             + N +S  EA+   +  + +DL     ++S   
Sbjct: 307  TITPVSFDETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLET 366

Query: 82   GLNTLTK--LCTLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRY 139
                + K  L  L    +L+ KV+  E++ NLTR+ V+ + +     L      K ++ +
Sbjct: 367  RAQAMEKDQLAQLLEEKDLLQKVQN-EKIENLTRMLVTSSSLTLQQELKAKR--KRRVTW 423

Query: 140  IDLHSNRIDSIHHLLQCMVGLHFLT-------NLILEKDGDDNPVCRLPGYRAVILQTL- 191
                 N++ + ++  Q  +  +  T       NL+ E D     VC      +  L TL 
Sbjct: 424  CLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREID---ESVCSESDVFSNTLDTLS 480

Query: 192  -----PQLRILDCKNIFGEPVNLTEINSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMP 246
                 P  ++L+ +NI            S+L  L    DNLV     L   ++E+  ++ 
Sbjct: 481  EIEWNPATKLLNQENI-----------ESELNSLRADYDNLVLDYEQLRTEKEEMELKLK 529

Query: 247  VITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIK-----LQKLD 301
                 +DE   LE+      +  L   +S  ++       +  DL+NE+      L++ +
Sbjct: 530  EKN-DLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKE 588

Query: 302  DQILQLLNET-SNSIDNV-------LE--KDPRPKRDTDITSESDYGNRKE-----CNRK 346
            DQI +L     S  ++N+       LE  +DP+  + T   +E+   + K       +  
Sbjct: 589  DQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSEN 648

Query: 347  VPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVS-SSLANCPMLQESEK 405
            +  + K+   A T + +++  + Y S +   +KM+    KEL  + + +     L + + 
Sbjct: 649  LELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKV 708

Query: 406  PKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAEN--KLMDYIDELHKHANEK-E 462
            PK  +  ++      +  + L +++++    R           L   ++ L K   +K E
Sbjct: 709  PKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSE 768

Query: 463  DIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLR 522
            ++H +         E++ +E   +G LE  + K ++++   T    K+ DQ+    ++ +
Sbjct: 769  ELHIITSEKDKLFSEVVHKESRVQGLLEE-IGKTKDDLAT-TQSNYKSTDQE---FQNFK 823

Query: 523  TLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSL--------HREREQA 574
            TL    E+  +   ++     + I  +  +A   D  +  L+T L         + RE  
Sbjct: 824  TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQ 883

Query: 575  QQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ 634
            ++L+++  LKEQ     LE R         D+  + + +E+    + +++  E++  L+Q
Sbjct: 884  ERLNEMEQLKEQ-----LENR---------DSTLQTVEREKTLITEKLQQTLEEVKTLTQ 929

Query: 635  QYMDLENEFRIALTVEARRFQ-DVKDGFE-NVATELAKSKHALIWAQRKENESSSLIKDL 692
            +  DL+ + + +L +E  + + D+ D    N+ T+                    L   L
Sbjct: 930  EKDDLK-QLQESLQIERDQLKSDIHDTVNMNIDTQ------------------EQLRNAL 970

Query: 693  TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISEL 752
              + + Q+T     SK+ +E + NL  + NT E   ++ +QK + I+  +  + +    L
Sbjct: 971  ESLKQHQETINTLKSKISEEVSRNLHMEENTGETK-DEFQQKMVGIDKKQDLEAKNTQTL 1029

Query: 753  AAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR-------KTN 805
             A       +  +RK++         SL Q + +L+  +ES+  E E L+       +  
Sbjct: 1030 TADVKDNEIIEQQRKIF---------SLIQEKNELQQMLESVIAEKEQLKTDLKENIEMT 1080

Query: 806  ESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQE---QLDEKS 862
              + + LR+    +  Q E + + K+   +K+  + R  +++ E+E+  +E   QL EK 
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQ 1140

Query: 863  SQL---DEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLET 919
             QL    E + ++++     E LK +LK KE+ LE +      L +K ++  E +  +  
Sbjct: 1141 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITK 1200

Query: 920  Q---VKEVKEKFENKEKKLKA---ERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQA 973
            +   +KE+++ FE +   L+    E + +    K  ++  H      +  +D +  +   
Sbjct: 1201 ERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSE 1260

Query: 974  EIAQLAN----EKQKCIDSANLKVHQIEKEMRELLEETCKNKKTM 1014
            + AQ+ N    EK        + V   E+E+   ++E  + ++TM
Sbjct: 1261 KTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETM 1305



 Score =  101 bits (252), Expect = 3e-21
 Identities = 190/897 (21%), Positives = 367/897 (40%), Gaps = 184/897 (20%)

Query: 253  DELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQN----------EIKLQKLD- 301
            DE +   QFAST      T +++   + E     +  ++ +          E + Q ++ 
Sbjct: 314  DETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEK 373

Query: 302  DQILQLLNETSNSIDNVLEKDPRPKRDT---DITSESDYGNRKECNRKVPRRSKIPYDAK 358
            DQ+ QLL E      ++L+K    K +     + + S    ++E   K  R+ ++ +   
Sbjct: 374  DQLAQLLEEK-----DLLQKVQNEKIENLTRMLVTSSSLTLQQELKAK--RKRRVTWCLG 426

Query: 359  TIQTIKHHN-------------KNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESE- 404
             I  +K+ N             K +   ++  R++      E  V S+  +   L E E 
Sbjct: 427  KINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDT--LSEIEW 484

Query: 405  KPKTEIIKVDQSHSEDNT----YQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANE 460
             P T+++  +   SE N+    Y +LV   +Q R ++   E+ E KL        K  N+
Sbjct: 485  NPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEK---EEMELKL--------KEKND 533

Query: 461  KEDIHSLALLTT-DRLKEIIFRERNSKGQL---EVMVHKLQNEIKKLTVELMKAKDQQED 516
             ++  +L   T  D+  ++I    N K  +   EV    L+NE+    VEL++ K   ED
Sbjct: 534  LDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSS-KVELLREK---ED 589

Query: 517  HLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQ 576
             +K L+    + +K+E  K     +   +    ++K +  D E      +L  +RE A  
Sbjct: 590  QIKKLQEYIDS-QKLENIKMDLSYSLESIEDPKQMKQTLFDAET----VALDAKRESAFL 644

Query: 577  LHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQY 636
              + L LKE+                      KE+A   K+ E  I+ YQ +++   +  
Sbjct: 645  RSENLELKEK---------------------MKELATTYKQMENDIQLYQSQLEAKKKMQ 683

Query: 637  MDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 696
            +DLE E + A   E  +   + DG         K    L+     E + + L K+L   V
Sbjct: 684  VDLEKELQSAFN-EITKLTSLIDG---------KVPKDLLCNLELEGKITDLQKELNKEV 733

Query: 697  KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 756
            +E +    EV  L +     L++  + +E L ++ + KS ++ ++  EK +L SE+  KE
Sbjct: 734  EENEALREEVILLSE-----LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKE 788

Query: 757  SLIFGLRTERKVWGHELA------------------------QQGSSLAQNRGKLEAQIE 792
            S + GL  E      +LA                        Q+   + +   ++  +I 
Sbjct: 789  SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIV 848

Query: 793  SLSRENE-------CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIK---- 841
            +LS+E +        L+      +  L+ K + + ++   + +LK+ L+ +D  ++    
Sbjct: 849  NLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVER 908

Query: 842  -------RLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKL------KQQLKG 888
                   +LQ+ + E++  TQE+ D K  Q    +E+ +  ++  + +      ++QL+ 
Sbjct: 909  EKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRN 968

Query: 889  KEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFE------NKEKKLKAERDKS 942
                L++ ++  +TL  K  ++     H+E    E K++F+      +K++ L+A+  ++
Sbjct: 969  ALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQT 1028

Query: 943  IELQKNAMEKLHSMDDAF-----KRQVDAIVEAHQAEIAQLANEKQKCIDS--------- 988
            +       E +      F     K ++  ++E+  AE  QL  + ++ I+          
Sbjct: 1029 LTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELR 1088

Query: 989  -------------ANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 1032
                         A  K H I+KE    L  TC     +E K+K+ +  L E QQ +
Sbjct: 1089 LLGDELKKQQEIVAQEKNHAIKKEGE--LSRTCDRLAEVEEKLKEKSQQLQEKQQQL 1143



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 167/825 (20%), Positives = 355/825 (43%), Gaps = 121/825 (14%)

Query: 291  LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 350
            LQ EI +   + ++L  + E S + + + E +   ++ T  T +S    R E  R +   
Sbjct: 1278 LQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQST--TKDSTTLARIEMER-LRLN 1334

Query: 351  SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEI 410
             K     + I+++     N  +      ++K   LKE ++  +LA    +QES+  + + 
Sbjct: 1335 EKFQESQEEIKSLTKERDNLKTIKEA-LEVKHDQLKE-HIRETLAK---IQESQSKQEQS 1389

Query: 411  IKVDQSHSEDNTYQSLVEQLDQEREKRWRAE----QAENKLMDYIDELHKHANEKEDIHS 466
            + + +  +E     S +EQ   +     R E        +L +  DE+   A EK+D+  
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR 1449

Query: 467  LALLTT-------DRLKEIIFRERNSKGQLEVM---VHKLQNEIKKLTVELMKAKDQQED 516
            L  +         + +KEI+ +   ++ +L+V    + + +  I +L V L + + +   
Sbjct: 1450 LQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIST 1509

Query: 517  HLKHLRTLEKTLE-KMERQKRQQQAAQIRLIQEVELKAS-------------AADREIYL 562
              K L  +   L+ K++    +++   I+ I EV+ K +             +A + I  
Sbjct: 1510 IQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIES 1569

Query: 563  LRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDA---DFQDALAKEIAKEEKKHE 619
                L    +++Q+  Q++  +++E ++  E  +   D    + ++ +AK    +EK+++
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1629

Query: 620  QM----IKEYQEK---IDVLSQQY----MDLEN--EFRIALTV-------EARRFQDVKD 659
             +    + E QEK   I+ L +Q+    ++LEN     I LT        E R     +D
Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERD 1689

Query: 660  GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVS-KLKQETAANLQ 718
               +V   L   +  L     KEN   ++ +DL    K+++ K+  +  K  QET   L+
Sbjct: 1690 DLRSVEETLKVERDQL-----KENLRETITRDLE---KQEELKIVHMHLKEHQETIDKLR 1741

Query: 719  -------NQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESL-----IFGLRTER 766
                   N+I+ ++  +E     +++ + LK ++   I+ +  KE       + G+ +E+
Sbjct: 1742 GIVSEKTNEISNMQKDLEHSND-ALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK 1800

Query: 767  KVWGHELAQQGSSLAQNRGKLEAQIESLSRENECL-------RKTNESDSDALRIKCKII 819
                 +L+     L  +  KL+ +I+ L      L        +T +  S+  ++K K I
Sbjct: 1801 T---DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK-KQI 1856

Query: 820  DDQTETIRKL------------------KDCLQEKDEHIKRLQEKITEIEKCTQEQLDEK 861
             DQ+ T+ KL                  K  ++E+D +++R++E +       +E L E 
Sbjct: 1857 KDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD-NLRRVEETLKLERDQLKESLQET 1915

Query: 862  SSQLDEVLEKLE-------RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELL 914
             ++  E+ ++L+        H E  +KL++++  K +++ +I+K       +   K + L
Sbjct: 1916 KARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQEL 1975

Query: 915  CHLETQVKEVKEKFENKEKKLK--AERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQ 972
               E Q+  VKE      KK+    +  K  E Q  +M+ +   +    +++   +E  +
Sbjct: 1976 QKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR 2035

Query: 973  AEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 1017
              +A+  +E ++  +S  ++  Q    +RE++    +N +    K
Sbjct: 2036 I-VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEK 2079



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 173/918 (18%), Positives = 384/918 (41%), Gaps = 99/918 (10%)

Query: 188  LQTLPQLRILDC------KNIFGEPVNL----TEINSSQLQCLEGLLDNLVSSDSPLNIS 237
            L+T  +L++  C      + I    VNL    TEI++ Q Q LE + D L +    +   
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ-LEAINDKLQNKIQEIYEK 1531

Query: 238  EDEI-IDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIK 296
            E++  I ++  +   ++EL   ++      D+ L S     +S   E  N   + Q EI+
Sbjct: 1532 EEQFNIKQISEVQEKVNELKQFKEHRKA-KDSALQSI----ESKMLELTNRLQESQEEIQ 1586

Query: 297  LQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKE--------CNRKVP 348
            +   + + ++ + E        +E+D   +   +I ++      KE         N    
Sbjct: 1587 IMIKEKEEMKRVQEALQ-----IERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQE 1641

Query: 349  RRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKT 408
            +  +I +  +  +T K + +N  +      ++    L+E+       +    ++  +   
Sbjct: 1642 KMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEM------RSVTKERDDLRSVE 1695

Query: 409  EIIKVDQSHSEDNTYQSLVEQLDQEREKRW------RAEQAENKLMDYIDE-LHKHANEK 461
            E +KV++   ++N  +++   L+++ E +         ++  +KL   + E  ++ +N +
Sbjct: 1696 ETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQ 1755

Query: 462  EDI-HSLALLTTDRLK---EIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDH 517
            +D+ HS   L    LK   E+     + K Q E  + KL+  + + T +L   +   E+ 
Sbjct: 1756 KDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET-IDKLRGIVSEKTDKLSNMQKDLENS 1814

Query: 518  LKHLRTLEKTLEKMERQ----KRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 573
               L+   + L+  E Q    K+     Q ++ +  +LK    D+ + L +  +      
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN-LNL 1873

Query: 574  AQQLHQLL-----ALKEQEHRKELETREFFTDADFQDALAK------EIAKEEKKHEQMI 622
            AQ+LH+ L      +KE+++ + +E          +++L +      EI +E K    + 
Sbjct: 1874 AQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLS 1933

Query: 623  KEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKE 682
            KE++E +D L ++     +E  I ++   +     KD  +    EL K +  L+  +   
Sbjct: 1934 KEHKETVDKLREKI----SEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989

Query: 683  NESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AANLQNQINTLEILIEDDKQKSIQIE 739
            N S   I ++  + K+ + +   +  ++ +       L   +  + I+ ++  +     E
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE 2049

Query: 740  LLKHEKVQLIS---ELAAKESLIFGLRTERKVWG----------HELAQQGSSLAQNRGK 786
             LK E+ Q I+   E+ A++     ++ E+++             E   +   L +   +
Sbjct: 2050 SLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE 2109

Query: 787  LEAQIESLSRENECLRKTNESDSD-ALRIKCKIIDD--QTETIRKL----KDCLQEKDEH 839
            ++   E L+R +  L K  E   + ++R+K  +     QT+ I KL    + C  E    
Sbjct: 2110 MDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRI 2169

Query: 840  IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 899
            +K+L+  ++ + K  +EQ +  +    + ++++E+  E   K++   +  +V   E+R  
Sbjct: 2170 MKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDL 2229

Query: 900  YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 959
                N   H +  L    E++   +K +F+      K E  + +E   N    +  + + 
Sbjct: 2230 KLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRK-EMTQFLEEWLNTRFDIEKLKNG 2288

Query: 960  FKRQVDAIVEAH---QAEIAQLANEKQKCID---SANLKVHQIEKEMRELLEETCKNKKT 1013
             +++ D I + +      I  + NE  +  +   + + +  Q  K ++E  E+  KN +T
Sbjct: 2289 IQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2348

Query: 1014 MEAKIKQLAFALNEIQQD 1031
            ++  +   A  +N   QD
Sbjct: 2349 LKTSLASGA-QVNPTTQD 2365



 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 162/832 (19%), Positives = 323/832 (38%), Gaps = 143/832 (17%)

Query: 197  LDCKNIFGEPVNLTEI---NSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRM-PVITAPI 252
            L+ +NI  E + LT+I   N  +++ +    D+L S +  L +  D++ + +   IT  +
Sbjct: 1658 LNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL 1717

Query: 253  D--ELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQL--- 307
            +  E + +           +     +      E +N + DL++     K  D  +Q    
Sbjct: 1718 EKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELR 1777

Query: 308  -----LNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR-SKIPYDAKTIQ 361
                 L E   +ID  L      K D     + D  N    N K+  +  ++  +   + 
Sbjct: 1778 IAHMHLKEQQETIDK-LRGIVSEKTDKLSNMQKDLENS---NAKLQEKIQELKANEHQLI 1833

Query: 362  TIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSHSEDN 421
            T+K         VS   ++K   +K+  ++ S      L  ++K    + ++     E +
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQ-IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD 1892

Query: 422  TYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFR 481
              + + E L  ER++   + Q E K  D   E+ +       +      T D+L+E I  
Sbjct: 1893 NLRRVEETLKLERDQLKESLQ-ETKARDL--EIQQELKTARMLSKEHKETVDKLREKISE 1949

Query: 482  ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAA 541
            +      ++  + K ++E++K   EL K + Q     + +    K + +ME+ K+Q +A 
Sbjct: 1950 KTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQ 2009

Query: 542  QIRL-----------------IQEVELKASAADREIYLLRTSLHREREQ-AQQLHQLLAL 583
             + +                 ++E+ + A   D E+  ++ SL  ER+Q    L +++A 
Sbjct: 2010 NLSMQSVRMDNFQLTKKLHESLEEIRIVAKERD-ELRRIKESLKMERDQFIATLREMIAR 2068

Query: 584  KEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID---VLSQQYMDLE 640
              Q H+ + E R     +D Q  L + + ++  + ++++K Y E  D    L++  +DLE
Sbjct: 2069 DRQNHQVKPEKRLL---SDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE 2125

Query: 641  NEFR----IALTVEA---------RRFQDVKDGFENVATE----LAKSKHALIWAQR-KE 682
             E      +++ V+A         +  + +    +  + E    + K K+ L +  + KE
Sbjct: 2126 KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185

Query: 683  NESSSLIK---DLTCMVKEQKTKLAEVSKLKQETAANL---------QNQINTLEILIED 730
             +  S+ K   D    V++QK  L ++  L+Q+              QN    +E +++D
Sbjct: 2186 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKD 2245

Query: 731  DKQKSI--------QIELLKHEKVQLISELAAK----ESLIFGLRTERK----------- 767
              +           Q+   + E  Q + E        E L  G++ E             
Sbjct: 2246 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNN 2305

Query: 768  ---VWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNES----------------D 808
                  +E  +     A    + E  ++SL  +NE L K  ++                D
Sbjct: 2306 RIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQD 2365

Query: 809  SDALRIKCKIIDDQTETIRKLKDCLQEKDEH---------------------IKRLQEKI 847
            +    +  +     TE IR+L++ L E  E                      I +LQ K+
Sbjct: 2366 NKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV 2425

Query: 848  TEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 899
             E  KC ++  +      D+V    + + E  E LK +L   +++LE+++ A
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL--VKIDLEKMKNA 2475


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score =  108 bits (271), Expect = 2e-23
 Identities = 124/611 (20%), Positives = 271/611 (44%), Gaps = 67/611 (10%)

Query: 372 SFVSCNRKMKPPYLKELY-----VSSSLANCPMLQESEKPKTEII--KVDQSHSEDNTYQ 424
           S V+  +K    Y++EL      +S  L    +  E  K K   +  K+    SE +  Q
Sbjct: 182 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ 241

Query: 425 SLVEQLDQEREK----------RWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR 474
             V++L ++ E+          +  A+    +L     +L     E E  + L      +
Sbjct: 242 LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL----NQQ 297

Query: 475 LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ 534
            +E ++R+     + E    K+Q + +K+  +  K ++Q+E   +    + +  EKM RQ
Sbjct: 298 QEEKMWRQEEKIQEWE---EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 354

Query: 535 KRQQQAAQIRLIQEVEL---KASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKE 591
           +      + ++ ++ E+   K     R+  ++     + RE  +++H+   ++EQE +++
Sbjct: 355 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 414

Query: 592 LETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEA 651
            E               ++I ++EK+ EQ  K ++++  +  Q+    E E ++    E 
Sbjct: 415 EE---------------EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 459

Query: 652 RRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQ 711
              Q      E +  E  + +   +W Q ++      I      + EQ+ K+ +    ++
Sbjct: 460 IHEQ------EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRK----QE 509

Query: 712 ETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGH 771
           E     + +I   E  I + ++K  + E    EK++   E+  +E     +  + K+W  
Sbjct: 510 EKVWRQEEKIREQEEKIREQEEKMWRQE----EKIREQEEMWREEEK---MHEQEKIWEE 562

Query: 772 ELAQ-QGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLK 830
           E  Q Q   + +   K+  Q E + R+ E +R+  E   +      K    Q E IR+ +
Sbjct: 563 EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK----QEEKIREQE 618

Query: 831 DCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKL---KQQLK 887
           + +QE++E I+  +EKI E E+ TQEQ ++   Q +++ E+ E+  E++E +   +++++
Sbjct: 619 EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR 678

Query: 888 GKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQK 947
            +E ++ E  +          ++ E +   E ++ E +EK + +E+K++ + +K  E + 
Sbjct: 679 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV 738

Query: 948 NAMEKLHSMDD 958
              ++   M +
Sbjct: 739 RLRQQEEKMQE 749



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 121/601 (20%), Positives = 266/601 (44%), Gaps = 58/601 (9%)

Query: 441  EQAENKLMDYIDELH---KHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQ 497
            +Q E +  D I  LH   K A E E   +L+ + T + K   + E  +K +  + +   +
Sbjct: 154  KQLEGEARDLISRLHDSWKFAGELEQ--ALSAVATQKKKADRYIEELTKERDALSLELYR 211

Query: 498  NEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAAD 557
            N I    ++   AK Q++  L      E  L   E +++ ++A  +   Q+++ +A    
Sbjct: 212  NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271

Query: 558  REIYLLRTSLHREREQAQQLHQLLALKEQEH-RKELETREFFTDADFQDALAKEIAKEEK 616
            +E+  +   L  + E+ +  ++L   +E++  R+E + +E+       +   +E  ++ +
Sbjct: 272  KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEW-------EEKIQEQEEKIR 324

Query: 617  KHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALI 676
            + E+ I+E +EK+    Q+ M  E E ++      RR +++    E    E  + +  ++
Sbjct: 325  EQEEKIREQEEKMR--RQEEMMWEKEEKM------RRQEEMMWEKE----EKMRRQEEMM 372

Query: 677  WAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSI 736
            W    E E     ++     KE+K +  E    +QE     + +    E + E +K++  
Sbjct: 373  W----EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 428

Query: 737  QIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSR 796
            + ++ + E+     E   +E        E+K+W  E         +   K + Q E + R
Sbjct: 429  EAKMWRQEEKIREQEEKIREQ-------EKKMWRQEEKIHEQEKIREEEKRQEQ-EEMWR 480

Query: 797  ENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQE 856
            + E + +  E            I  Q E + + ++ +++++E + R +EKI E E+  +E
Sbjct: 481  QEEKIHEQEE------------IWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528

Query: 857  QLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCH 916
            Q ++   Q +++ E+ E   E ++  +Q+   +E + +E          K  ++ E +  
Sbjct: 529  QEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR 588

Query: 917  LETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAH---QA 973
             E +++E +EK + +E+K+  + +K  E +    EK+   ++  + Q + I E     Q 
Sbjct: 589  QEEKIREQEEKRQEQEEKMWKQEEKIREQE----EKIQEQEEKIREQEEKIREQEEMTQE 644

Query: 974  EIAQLANEKQKCIDSANLKVHQIEKEMR--ELLEETCKNKKTMEAKIKQLAFALNEIQQD 1031
            +  ++  +++K  +       Q E   R  E + E  K  +  E KI++    + E ++ 
Sbjct: 645  QEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 704

Query: 1032 M 1032
            M
Sbjct: 705  M 705


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  108 bits (270), Expect = 3e-23
 Identities = 161/798 (20%), Positives = 335/798 (41%), Gaps = 97/798 (12%)

Query: 283  EKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKE 342
            EKN  +  LQ E +L    +++   L      ++ +L +      +  +  E D G + +
Sbjct: 888  EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE-----MEARLEEEEDRGQQLQ 942

Query: 343  CNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQE 402
              RK   +  +  + +  +      K     V+   K+K   L++  +     N  + +E
Sbjct: 943  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--LEDEILVMDDQNNKLSKE 1000

Query: 403  SEKPKTEIIKVDQSHSED-----------NTYQSLVEQLDQEREKRWRAEQAENKLMDYI 451
             +  +  I  +  + +E+           N ++S++ +L+   +K  ++ Q   KL    
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK--- 1057

Query: 452  DELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAK 511
                K   +  D H        ++ E+  +    + +L+  + +L +EI           
Sbjct: 1058 ---RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---------- 1104

Query: 512  DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER 571
             Q+ + LK +R LE  +  ++     ++AA+     + E +      E+  L+T L    
Sbjct: 1105 -QKNNALKKIRELEGHISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTL 1159

Query: 572  EQAQQLHQLLALKEQEH---RKELETREFFTDADFQDALAKEIAKEEKKHEQM--IKEYQ 626
            +      +L A +EQE    +K L+      +A  Q+   K     E+  EQ+   K  +
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219

Query: 627  EKID----VLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATEL----AKSKHALIWA 678
              +D     L ++  DL  E R+ L    +  +  K   E    EL    +  + A    
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278

Query: 679  QRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK---S 735
              K ++  + ++ +T M+ E + K  +++K     ++ LQ+   T E+L E+ +QK   S
Sbjct: 1279 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQKLNVS 1335

Query: 736  IQIELLKHEKV----QLISELAAKESLIFGLRT------ERKVWGHELAQQGSSLAQNRG 785
             ++  L+ E+     QL  E+ AK++L   + T      + K    + A    +L + + 
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 786  KLEAQIESLSRENE-------CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDE 838
            + + +IE+L+++ E        L KT       L      +D+Q + +  L+   ++ D+
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455

Query: 839  HI---KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEE 895
             +   K +  K  +     + +  EK ++   +   LE   E KE+L++  K  + E+E+
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515

Query: 896  IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHS 955
            +  +   + +  H+  +    LETQ++E+K + E  E +L+A  D  + L+ N    + +
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN----MQA 1571

Query: 956  MDDAFKRQVDAIVEAHQAEIAQLANE------------KQKCIDSANLKVHQIEKEMREL 1003
            +   F+R + A  E ++ +  QL  +            KQ+ + +A  K  ++E ++++L
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK--KLEGDLKDL 1629

Query: 1004 LEETCKNKKTMEAKIKQL 1021
              +     K  E  IKQL
Sbjct: 1630 ELQADSAIKGREEAIKQL 1647



 Score =  104 bits (259), Expect = 5e-22
 Identities = 136/560 (24%), Positives = 256/560 (45%), Gaps = 70/560 (12%)

Query: 491  VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVE 550
            + V + + E++    EL K K++Q+     L+ LE+   ++  +K   Q    +L  E E
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE---QLQAETE 901

Query: 551  LKASAADREIYLLRTSLHREREQAQQLHQLLA-LKEQEHRKELETREFFTDA----DFQD 605
            L A A +  + L      +++E  + LH++ A L+E+E R +    E    A    D ++
Sbjct: 902  LYAEAEEMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 606  ALAKEIAKEEKKH------EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKD 659
             L +E A  +K        E  IK+ +++I V+  Q   L  E ++   +E R    + D
Sbjct: 958  QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEER----ISD 1010

Query: 660  GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AAN 716
               N+A E  K+K+      + +N+  S+I +L   +K+++    E+ KLK++    A++
Sbjct: 1011 LTTNLAEEEEKAKNLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066

Query: 717  LQNQINTLEILIEDDK-QKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGH--EL 773
               QI  L+  I + K Q + + E L+    +L  E+A K +    L+  R++ GH  +L
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN---ALKKIRELEGHISDL 1123

Query: 774  AQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCL 833
             +   S    R K E Q   L  E E L+   E   D+   + ++   + + +  LK  L
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183

Query: 834  QEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVEL 893
               DE  +  + ++ E+ +   + ++E    L E LE+ +R     +K KQ L+ +  +L
Sbjct: 1184 ---DEETRSHEAQVQEMRQKHAQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADL 1236

Query: 894  E-EIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 952
              E+R          H K +L    E QV+E++ K  + E+      DK  +LQ N +E 
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKL----EAQVQELQSKCSDGERARAELNDKVHKLQ-NEVES 1291

Query: 953  LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKK 1012
            +  M +  + +   + +    ++A L+++ Q               + +ELL+E  + K 
Sbjct: 1292 VTGMLNEAEGKAIKLAK----DVASLSSQLQ---------------DTQELLQEETRQKL 1332

Query: 1013 TMEAKIKQLAFALNEIQQDM 1032
             +  K++QL    N +Q  +
Sbjct: 1333 NVSTKLRQLEEERNSLQDQL 1352



 Score =  103 bits (257), Expect = 8e-22
 Identities = 155/730 (21%), Positives = 310/730 (42%), Gaps = 121/730 (16%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKL----MDYIDELHK 456
            +E+   + ++ ++ Q H++    + L EQL+Q +  +   ++ +  L     D   EL  
Sbjct: 1185 EETRSHEAQVQEMRQKHAQ--AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242

Query: 457  HANEKEDIHSLALLTTDRLKEIIFR---ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 513
                K+++         +++E+  +      ++ +L   VHKLQNE++ +T  L +A+ +
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302

Query: 514  QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 573
                 K + +L   L+  + Q+  Q+  + +L   V  K    + E   L+  L  E E 
Sbjct: 1303 AIKLAKDVASLSSQLQ--DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEA 1358

Query: 574  AQQLHQ---LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID 630
             Q L +    L ++  + +K+L+  +F   A   +AL +   + +K+ E + ++Y+EK  
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQ--DF---ASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413

Query: 631  V--------------LSQQYMDLENEFRIALTVEA--RRFQDVKDGFENVATELAKSK-H 673
                           L    +DL+N+ ++   +E   R+F  +    +N++++ A  +  
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473

Query: 674  ALIWAQRKENESSSLIKDL--TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDD 731
            A   A+ KE ++ SL + L      KE+  +  ++ K + E   + ++ +      +E  
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533

Query: 732  KQK-SIQIELLKHEKVQLISELAAKESLIFGLRTERKV----WGHELAQQGSSLAQNRGK 786
            K+    Q+E +K +  +L  EL A E     L    +     +  +L  +     + R +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593

Query: 787  LEAQIESLSRENECLRKTN-------------------ESDS------DALRIKCKIIDD 821
            L+ Q+     E E  RK                     ++DS      +A++   K+   
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653

Query: 822  QTETIRKLKDCLQEKDE-----------------HIKRLQEKITEIEKCTQEQLDEKSSQ 864
              +  R+L+D    +DE                  + +LQE +   E+  ++   EK   
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713

Query: 865  LDEVLEKLERHN---ERKEKLKQQLKGKEVELEEIR---KAYSTLNRKWHDKGELLCHLE 918
             +E+   L   N   + K +L+ ++   E ELEE +   +A S   RK   + E L +  
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 919  TQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQL 978
               +   +K E+  ++L+ +        K    KLH M+ A K +  + + A +A+IAQL
Sbjct: 1774 ATERSTAQKNESARQQLERQN-------KELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826

Query: 979  -------ANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTME----------AKIKQL 1021
                   A EKQ    +A   + Q +K+++E+L +    +K  E          A++KQL
Sbjct: 1827 EEQVEQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882

Query: 1022 AFALNEIQQD 1031
               L E +++
Sbjct: 1883 KRQLEEAEEE 1892



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 141/670 (21%), Positives = 285/670 (42%), Gaps = 84/670 (12%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLV-EQLDQEREKRWRAEQAENKLMDYIDELHKHAN 459
            +  +K + E+ +++Q HS+    ++L+ EQL  E E    AE+   +L     EL     
Sbjct: 866  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL----- 920

Query: 460  EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 519
             +E +H +         E    E   +GQ      +LQ E KK+  +++  ++Q E+   
Sbjct: 921  -EEILHEM---------EARLEEEEDRGQ------QLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 520  HLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADRE-----IYLLRTSLHREREQA 574
              + L+  LEK+  + + ++     L+ + +    + +R+     I  L T+L  E E+A
Sbjct: 965  ARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022

Query: 575  QQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ 634
            + L + L  K +    ELE R        ++   +E+ K ++K E    ++ E+I  L  
Sbjct: 1023 KNLTK-LKNKHESMISELEVR-----LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076

Query: 635  QYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTC 694
            Q  +L+ +        A++ ++++     +  E+A+  +AL   +  E   S L +DL  
Sbjct: 1077 QIAELKMQL-------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129

Query: 695  ------MVKEQKTKLAE--------------VSKLKQETAANLQNQINTL-EILIEDDKQ 733
                    ++QK  L E               +  +QE  A  + ++  L + L E+ + 
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189

Query: 734  KSIQIELLKHEKVQLISELA--------AKESLIFGLRTERKVWG------HELAQQGSS 779
               Q++ ++ +  Q + EL         AK +L    +T  K           L Q    
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249

Query: 780  LAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEH 839
            +   + KLEAQ++ L  +++C     E     L  K   + ++ E++  + +  + K   
Sbjct: 1250 VEHKKKKLEAQVQEL--QSKC--SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305

Query: 840  IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 899
            + +    ++   + TQE L E++ Q   V  KL +  E +  L+ QL  +    + + + 
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365

Query: 900  YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 959
             STLN +  D  + L    + V+ ++E  +  +K+++    +  E +  A +KL    + 
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKNR 1424

Query: 960  FKRQVDAIVE--AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 1017
             ++++D +V    +Q ++     +KQ+  D    +   I  +  +  +      +  E K
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484

Query: 1018 IKQLAFALNE 1027
               LA AL E
Sbjct: 1485 ALSLARALEE 1494



 Score = 84.0 bits (206), Expect = 7e-16
 Identities = 134/627 (21%), Positives = 269/627 (42%), Gaps = 82/627 (13%)

Query: 399  MLQESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQ-----------AENK 446
            +LQE  + K  +  K+ Q   E N   SL +QLD+E E +   E+           ++ K
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 447  LMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVE 506
            L D+   +      K+         T + +E    +  +  +LE   ++LQ E+  L V+
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEE----KAAAYDKLEKTKNRLQQELDDLVVD 1435

Query: 507  LMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS 566
            L       ++  + +  LEK   K ++   +++    +   E + +A A  RE      S
Sbjct: 1436 L-------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD-RAEAEAREKETKALS 1487

Query: 567  LHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQ 626
            L R  E+A +  + L    +  + E+E  +  +  D       E+ K ++  E  ++E +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545

Query: 627  EKIDVLSQQYMDLEN-EFRIALTVEARRFQDVKD-----------------GFENVATEL 668
             +++ L  +    E+ + R+ + ++A + Q  +D                       TEL
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605

Query: 669  A--KSKHALIWAQRKENESSSLIKDLTCM----VKEQKTKLAEVSKLK---QETAANLQN 719
               + + AL  A +K+ E    +KDL       +K ++  + ++ KL+   ++    L++
Sbjct: 1606 EDERKQRALAAAAKKKLEGD--LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663

Query: 720  QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGS- 778
               + + +    K+   + + L+ + +QL  +LAA E        E++    ELA   S 
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 779  --SLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDD-------QTETIRKL 829
              +L   + +LEA+I  L  E E  +   E+ SD +R   +  +        +  T +K 
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 830  KDCLQEKDEHIKRLQEKITEIE-------KCTQEQLDEKSSQLDEVLEKLERHNERKEK- 881
            +   Q+ +   K L+ K+ E+E       K T   L+ K +QL+E +E+  R  +   K 
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 882  LKQQ---LKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFEN---KEKKL 935
            LKQ+   LK   +++E+ RK       +       +  L+ Q++E +E+ +      +KL
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903

Query: 936  KAERDKSIELQKNAMEKLHSMDDAFKR 962
            + E D++ E  +    +++++    +R
Sbjct: 1904 QRELDEATESNEAMGREVNALKSKLRR 1930



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 96/457 (21%), Positives = 203/457 (44%), Gaps = 61/457 (13%)

Query: 580  LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE---YQEKIDVLSQQY 636
            LL +  QE   + +  E     + Q     E+ + E+KH Q+ +E    QE++   ++ Y
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 637  MDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 696
             + E E R+ L  + +  +++    E    E  + +   + A+RK+     L  DL   +
Sbjct: 904  AEAE-EMRVRLAAKKQELEEILHEME-ARLEEEEDRGQQLQAERKKMAQQML--DLEEQL 959

Query: 697  KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIE--LLKHEKVQLISELAA 754
            +E++    ++   K    A ++   +  EIL+ DD+   +  E  LL+     L + LA 
Sbjct: 960  EEEEAARQKLQLEKVTAEAKIKKLED--EILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017

Query: 755  KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC-LRKTNESDSDALR 813
            +E                        A+N  KL+ + ES+  E E  L+K  +S  +  +
Sbjct: 1018 EE----------------------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055

Query: 814  IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE 873
            +K K+  D ++   ++ D LQ +   +K    K  E  +    +LD++ +Q +  L+K+ 
Sbjct: 1056 LKRKLEGDASDFHEQIAD-LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI- 1113

Query: 874  RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 933
                   +L+  +   + +L+  R A +   ++  D GE L  L+T++++  +     ++
Sbjct: 1114 ------RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQ 1166

Query: 934  KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 993
            +L+A+R++ + + K A+              D    +H+A++ ++  +  + ++    ++
Sbjct: 1167 ELRAKREQEVTVLKKAL--------------DEETRSHEAQVQEMRQKHAQAVEELTEQL 1212

Query: 994  HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 1030
             Q ++    L     KNK+T+E +   LA  L  + Q
Sbjct: 1213 EQFKRAKANL----DKNKQTLEKENADLAGELRVLGQ 1245



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 138/648 (21%), Positives = 280/648 (43%), Gaps = 83/648 (12%)

Query: 291  LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 350
            LQ E + +      L+ L E  NS+ + L+++   K++ +    S    +   ++K    
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSDSKK---- 1378

Query: 351  SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEI 410
             K+   A T++ ++   K +   +          L + Y   + A      + EK K  +
Sbjct: 1379 -KLQDFASTVEALEEGKKRFQKEIE--------NLTQQYEEKAAA----YDKLEKTKNRL 1425

Query: 411  IK-VDQSHSEDNTYQSLVEQLDQEREK--RWRAEQAE--NKLMDYIDELHKHANEKED-I 464
             + +D    + +  + LV  L++++ K  +  AE+    +K  D  D     A EKE   
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485

Query: 465  HSLALLTTDRLKEIIFRERNSK---GQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHL 521
             SLA    + L+     ER +K    ++E +V   ++++ K   EL K+K   E  ++ +
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEM 1544

Query: 522  RTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL 581
            +T    LE++E + +  + A++RL  EV ++A     E       L    EQ ++  + L
Sbjct: 1545 KT---QLEELEDELQATEDAKLRL--EVNMQALKGQFE-----RDLQARDEQNEEKRRQL 1594

Query: 582  ALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLEN 641
              +  E+  ELE      D   Q ALA   A  +KK E  +K+ + + D   +   +   
Sbjct: 1595 QRQLHEYETELE------DERKQRALA---AAAKKKLEGDLKDLELQADSAIKGREEAIK 1645

Query: 642  EFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKT 701
            + R  L  + + FQ           E A++    I+A  KENE  +   +   M  ++  
Sbjct: 1646 QLR-KLQAQMKDFQR--------ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 702  KLAEVSKL-----KQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 756
              AE ++      K+E A  L + ++    L ++ ++   +I  L+ E  +    + A  
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756

Query: 757  SLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR-KTNESDSD----- 810
              +     + +   +ELA + S+  +N    E+  + L R+N+ LR K +E +       
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKN----ESARQQLERQNKELRSKLHEMEGAVKSKF 1812

Query: 811  -----ALRIKCKIIDDQTETIRKLKDC----LQEKDEHIKRLQEKITEIEKCTQ---EQL 858
                 AL  K   +++Q E   + K      L++KD+ +K +  ++ +  K  +   EQ 
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872

Query: 859  DEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 906
            ++ ++++ ++  +LE   E  +++    +  + EL+E  ++   + R+
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 49/200 (24%), Positives = 99/200 (49%), Gaps = 8/200 (4%)

Query: 828  KLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLK 887
            K+K  LQ   +  + +Q K  E++K T+E+  +  ++L E+ +K  +  E K  L++QL+
Sbjct: 840  KVKPLLQVTRQE-EEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 897

Query: 888  GKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQK 947
             +     E  +    L  K  +  E+L  +E +++E     E++ ++L+AER K  +   
Sbjct: 898  AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRGQQLQAERKKMAQQML 953

Query: 948  NAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEET 1007
            +  E+L   ++A ++++       +A+I +L +E    +D  N K+ +  K + E + + 
Sbjct: 954  DLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERISDL 1011

Query: 1008 CKNKKTMEAKIKQLAFALNE 1027
              N    E K K L    N+
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNK 1031


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  108 bits (270), Expect = 3e-23
 Identities = 161/798 (20%), Positives = 335/798 (41%), Gaps = 97/798 (12%)

Query: 283  EKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKE 342
            EKN  +  LQ E +L    +++   L      ++ +L +      +  +  E D G + +
Sbjct: 895  EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE-----MEARLEEEEDRGQQLQ 949

Query: 343  CNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQE 402
              RK   +  +  + +  +      K     V+   K+K   L++  +     N  + +E
Sbjct: 950  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--LEDEILVMDDQNNKLSKE 1007

Query: 403  SEKPKTEIIKVDQSHSED-----------NTYQSLVEQLDQEREKRWRAEQAENKLMDYI 451
             +  +  I  +  + +E+           N ++S++ +L+   +K  ++ Q   KL    
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK--- 1064

Query: 452  DELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAK 511
                K   +  D H        ++ E+  +    + +L+  + +L +EI           
Sbjct: 1065 ---RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---------- 1111

Query: 512  DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER 571
             Q+ + LK +R LE  +  ++     ++AA+     + E +      E+  L+T L    
Sbjct: 1112 -QKNNALKKIRELEGHISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTL 1166

Query: 572  EQAQQLHQLLALKEQEH---RKELETREFFTDADFQDALAKEIAKEEKKHEQM--IKEYQ 626
            +      +L A +EQE    +K L+      +A  Q+   K     E+  EQ+   K  +
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226

Query: 627  EKID----VLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATEL----AKSKHALIWA 678
              +D     L ++  DL  E R+ L    +  +  K   E    EL    +  + A    
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285

Query: 679  QRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK---S 735
              K ++  + ++ +T M+ E + K  +++K     ++ LQ+   T E+L E+ +QK   S
Sbjct: 1286 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQKLNVS 1342

Query: 736  IQIELLKHEKV----QLISELAAKESLIFGLRT------ERKVWGHELAQQGSSLAQNRG 785
             ++  L+ E+     QL  E+ AK++L   + T      + K    + A    +L + + 
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 786  KLEAQIESLSRENE-------CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDE 838
            + + +IE+L+++ E        L KT       L      +D+Q + +  L+   ++ D+
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462

Query: 839  HI---KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEE 895
             +   K +  K  +     + +  EK ++   +   LE   E KE+L++  K  + E+E+
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522

Query: 896  IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHS 955
            +  +   + +  H+  +    LETQ++E+K + E  E +L+A  D  + L+ N    + +
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN----MQA 1578

Query: 956  MDDAFKRQVDAIVEAHQAEIAQLANE------------KQKCIDSANLKVHQIEKEMREL 1003
            +   F+R + A  E ++ +  QL  +            KQ+ + +A  K  ++E ++++L
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK--KLEGDLKDL 1636

Query: 1004 LEETCKNKKTMEAKIKQL 1021
              +     K  E  IKQL
Sbjct: 1637 ELQADSAIKGREEAIKQL 1654



 Score =  104 bits (259), Expect = 5e-22
 Identities = 136/560 (24%), Positives = 256/560 (45%), Gaps = 70/560 (12%)

Query: 491  VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVE 550
            + V + + E++    EL K K++Q+     L+ LE+   ++  +K   Q    +L  E E
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE---QLQAETE 908

Query: 551  LKASAADREIYLLRTSLHREREQAQQLHQLLA-LKEQEHRKELETREFFTDA----DFQD 605
            L A A +  + L      +++E  + LH++ A L+E+E R +    E    A    D ++
Sbjct: 909  LYAEAEEMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 606  ALAKEIAKEEKKH------EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKD 659
             L +E A  +K        E  IK+ +++I V+  Q   L  E ++   +E R    + D
Sbjct: 965  QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEER----ISD 1017

Query: 660  GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AAN 716
               N+A E  K+K+      + +N+  S+I +L   +K+++    E+ KLK++    A++
Sbjct: 1018 LTTNLAEEEEKAKNLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073

Query: 717  LQNQINTLEILIEDDK-QKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGH--EL 773
               QI  L+  I + K Q + + E L+    +L  E+A K +    L+  R++ GH  +L
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN---ALKKIRELEGHISDL 1130

Query: 774  AQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCL 833
             +   S    R K E Q   L  E E L+   E   D+   + ++   + + +  LK  L
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190

Query: 834  QEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVEL 893
               DE  +  + ++ E+ +   + ++E    L E LE+ +R     +K KQ L+ +  +L
Sbjct: 1191 ---DEETRSHEAQVQEMRQKHAQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADL 1243

Query: 894  E-EIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 952
              E+R          H K +L    E QV+E++ K  + E+      DK  +LQ N +E 
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKL----EAQVQELQSKCSDGERARAELNDKVHKLQ-NEVES 1298

Query: 953  LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKK 1012
            +  M +  + +   + +    ++A L+++ Q               + +ELL+E  + K 
Sbjct: 1299 VTGMLNEAEGKAIKLAK----DVASLSSQLQ---------------DTQELLQEETRQKL 1339

Query: 1013 TMEAKIKQLAFALNEIQQDM 1032
             +  K++QL    N +Q  +
Sbjct: 1340 NVSTKLRQLEEERNSLQDQL 1359



 Score =  103 bits (257), Expect = 8e-22
 Identities = 155/730 (21%), Positives = 310/730 (42%), Gaps = 121/730 (16%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKL----MDYIDELHK 456
            +E+   + ++ ++ Q H++    + L EQL+Q +  +   ++ +  L     D   EL  
Sbjct: 1192 EETRSHEAQVQEMRQKHAQ--AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249

Query: 457  HANEKEDIHSLALLTTDRLKEIIFR---ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 513
                K+++         +++E+  +      ++ +L   VHKLQNE++ +T  L +A+ +
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309

Query: 514  QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 573
                 K + +L   L+  + Q+  Q+  + +L   V  K    + E   L+  L  E E 
Sbjct: 1310 AIKLAKDVASLSSQLQ--DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEA 1365

Query: 574  AQQLHQ---LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID 630
             Q L +    L ++  + +K+L+  +F   A   +AL +   + +K+ E + ++Y+EK  
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQ--DF---ASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420

Query: 631  V--------------LSQQYMDLENEFRIALTVEA--RRFQDVKDGFENVATELAKSK-H 673
                           L    +DL+N+ ++   +E   R+F  +    +N++++ A  +  
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480

Query: 674  ALIWAQRKENESSSLIKDL--TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDD 731
            A   A+ KE ++ SL + L      KE+  +  ++ K + E   + ++ +      +E  
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540

Query: 732  KQK-SIQIELLKHEKVQLISELAAKESLIFGLRTERKV----WGHELAQQGSSLAQNRGK 786
            K+    Q+E +K +  +L  EL A E     L    +     +  +L  +     + R +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600

Query: 787  LEAQIESLSRENECLRKTN-------------------ESDS------DALRIKCKIIDD 821
            L+ Q+     E E  RK                     ++DS      +A++   K+   
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660

Query: 822  QTETIRKLKDCLQEKDE-----------------HIKRLQEKITEIEKCTQEQLDEKSSQ 864
              +  R+L+D    +DE                  + +LQE +   E+  ++   EK   
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720

Query: 865  LDEVLEKLERHN---ERKEKLKQQLKGKEVELEEIR---KAYSTLNRKWHDKGELLCHLE 918
             +E+   L   N   + K +L+ ++   E ELEE +   +A S   RK   + E L +  
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 919  TQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQL 978
               +   +K E+  ++L+ +        K    KLH M+ A K +  + + A +A+IAQL
Sbjct: 1781 ATERSTAQKNESARQQLERQN-------KELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833

Query: 979  -------ANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTME----------AKIKQL 1021
                   A EKQ    +A   + Q +K+++E+L +    +K  E          A++KQL
Sbjct: 1834 EEQVEQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889

Query: 1022 AFALNEIQQD 1031
               L E +++
Sbjct: 1890 KRQLEEAEEE 1899



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 141/670 (21%), Positives = 285/670 (42%), Gaps = 84/670 (12%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLV-EQLDQEREKRWRAEQAENKLMDYIDELHKHAN 459
            +  +K + E+ +++Q HS+    ++L+ EQL  E E    AE+   +L     EL     
Sbjct: 873  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL----- 927

Query: 460  EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 519
             +E +H +         E    E   +GQ      +LQ E KK+  +++  ++Q E+   
Sbjct: 928  -EEILHEM---------EARLEEEEDRGQ------QLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 520  HLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADRE-----IYLLRTSLHREREQA 574
              + L+  LEK+  + + ++     L+ + +    + +R+     I  L T+L  E E+A
Sbjct: 972  ARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029

Query: 575  QQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ 634
            + L + L  K +    ELE R        ++   +E+ K ++K E    ++ E+I  L  
Sbjct: 1030 KNLTK-LKNKHESMISELEVR-----LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083

Query: 635  QYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTC 694
            Q  +L+ +        A++ ++++     +  E+A+  +AL   +  E   S L +DL  
Sbjct: 1084 QIAELKMQL-------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136

Query: 695  ------MVKEQKTKLAE--------------VSKLKQETAANLQNQINTL-EILIEDDKQ 733
                    ++QK  L E               +  +QE  A  + ++  L + L E+ + 
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196

Query: 734  KSIQIELLKHEKVQLISELA--------AKESLIFGLRTERKVWG------HELAQQGSS 779
               Q++ ++ +  Q + EL         AK +L    +T  K           L Q    
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256

Query: 780  LAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEH 839
            +   + KLEAQ++ L  +++C     E     L  K   + ++ E++  + +  + K   
Sbjct: 1257 VEHKKKKLEAQVQEL--QSKC--SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312

Query: 840  IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 899
            + +    ++   + TQE L E++ Q   V  KL +  E +  L+ QL  +    + + + 
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 900  YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 959
             STLN +  D  + L    + V+ ++E  +  +K+++    +  E +  A +KL    + 
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKNR 1431

Query: 960  FKRQVDAIVE--AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 1017
             ++++D +V    +Q ++     +KQ+  D    +   I  +  +  +      +  E K
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

Query: 1018 IKQLAFALNE 1027
               LA AL E
Sbjct: 1492 ALSLARALEE 1501



 Score = 84.0 bits (206), Expect = 7e-16
 Identities = 134/627 (21%), Positives = 269/627 (42%), Gaps = 82/627 (13%)

Query: 399  MLQESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQ-----------AENK 446
            +LQE  + K  +  K+ Q   E N   SL +QLD+E E +   E+           ++ K
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 447  LMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVE 506
            L D+   +      K+         T + +E    +  +  +LE   ++LQ E+  L V+
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEE----KAAAYDKLEKTKNRLQQELDDLVVD 1442

Query: 507  LMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS 566
            L       ++  + +  LEK   K ++   +++    +   E + +A A  RE      S
Sbjct: 1443 L-------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD-RAEAEAREKETKALS 1494

Query: 567  LHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQ 626
            L R  E+A +  + L    +  + E+E  +  +  D       E+ K ++  E  ++E +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552

Query: 627  EKIDVLSQQYMDLEN-EFRIALTVEARRFQDVKD-----------------GFENVATEL 668
             +++ L  +    E+ + R+ + ++A + Q  +D                       TEL
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612

Query: 669  A--KSKHALIWAQRKENESSSLIKDLTCM----VKEQKTKLAEVSKLK---QETAANLQN 719
               + + AL  A +K+ E    +KDL       +K ++  + ++ KL+   ++    L++
Sbjct: 1613 EDERKQRALAAAAKKKLEGD--LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670

Query: 720  QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGS- 778
               + + +    K+   + + L+ + +QL  +LAA E        E++    ELA   S 
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 779  --SLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDD-------QTETIRKL 829
              +L   + +LEA+I  L  E E  +   E+ SD +R   +  +        +  T +K 
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 830  KDCLQEKDEHIKRLQEKITEIE-------KCTQEQLDEKSSQLDEVLEKLERHNERKEK- 881
            +   Q+ +   K L+ K+ E+E       K T   L+ K +QL+E +E+  R  +   K 
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 882  LKQQ---LKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFEN---KEKKL 935
            LKQ+   LK   +++E+ RK       +       +  L+ Q++E +E+ +      +KL
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910

Query: 936  KAERDKSIELQKNAMEKLHSMDDAFKR 962
            + E D++ E  +    +++++    +R
Sbjct: 1911 QRELDEATESNEAMGREVNALKSKLRR 1937



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 96/457 (21%), Positives = 203/457 (44%), Gaps = 61/457 (13%)

Query: 580  LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE---YQEKIDVLSQQY 636
            LL +  QE   + +  E     + Q     E+ + E+KH Q+ +E    QE++   ++ Y
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 637  MDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 696
             + E E R+ L  + +  +++    E    E  + +   + A+RK+     L  DL   +
Sbjct: 911  AEAE-EMRVRLAAKKQELEEILHEME-ARLEEEEDRGQQLQAERKKMAQQML--DLEEQL 966

Query: 697  KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIE--LLKHEKVQLISELAA 754
            +E++    ++   K    A ++   +  EIL+ DD+   +  E  LL+     L + LA 
Sbjct: 967  EEEEAARQKLQLEKVTAEAKIKKLED--EILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024

Query: 755  KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC-LRKTNESDSDALR 813
            +E                        A+N  KL+ + ES+  E E  L+K  +S  +  +
Sbjct: 1025 EE----------------------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 814  IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE 873
            +K K+  D ++   ++ D LQ +   +K    K  E  +    +LD++ +Q +  L+K+ 
Sbjct: 1063 LKRKLEGDASDFHEQIAD-LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI- 1120

Query: 874  RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 933
                   +L+  +   + +L+  R A +   ++  D GE L  L+T++++  +     ++
Sbjct: 1121 ------RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQ 1173

Query: 934  KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 993
            +L+A+R++ + + K A+              D    +H+A++ ++  +  + ++    ++
Sbjct: 1174 ELRAKREQEVTVLKKAL--------------DEETRSHEAQVQEMRQKHAQAVEELTEQL 1219

Query: 994  HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 1030
             Q ++    L     KNK+T+E +   LA  L  + Q
Sbjct: 1220 EQFKRAKANL----DKNKQTLEKENADLAGELRVLGQ 1252



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 138/648 (21%), Positives = 280/648 (43%), Gaps = 83/648 (12%)

Query: 291  LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 350
            LQ E + +      L+ L E  NS+ + L+++   K++ +    S    +   ++K    
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSDSKK---- 1385

Query: 351  SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEI 410
             K+   A T++ ++   K +   +          L + Y   + A      + EK K  +
Sbjct: 1386 -KLQDFASTVEALEEGKKRFQKEIE--------NLTQQYEEKAAA----YDKLEKTKNRL 1432

Query: 411  IK-VDQSHSEDNTYQSLVEQLDQEREK--RWRAEQAE--NKLMDYIDELHKHANEKED-I 464
             + +D    + +  + LV  L++++ K  +  AE+    +K  D  D     A EKE   
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492

Query: 465  HSLALLTTDRLKEIIFRERNSK---GQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHL 521
             SLA    + L+     ER +K    ++E +V   ++++ K   EL K+K   E  ++ +
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEM 1551

Query: 522  RTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL 581
            +T    LE++E + +  + A++RL  EV ++A     E       L    EQ ++  + L
Sbjct: 1552 KT---QLEELEDELQATEDAKLRL--EVNMQALKGQFE-----RDLQARDEQNEEKRRQL 1601

Query: 582  ALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLEN 641
              +  E+  ELE      D   Q ALA   A  +KK E  +K+ + + D   +   +   
Sbjct: 1602 QRQLHEYETELE------DERKQRALA---AAAKKKLEGDLKDLELQADSAIKGREEAIK 1652

Query: 642  EFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKT 701
            + R  L  + + FQ           E A++    I+A  KENE  +   +   M  ++  
Sbjct: 1653 QLR-KLQAQMKDFQR--------ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 702  KLAEVSKL-----KQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 756
              AE ++      K+E A  L + ++    L ++ ++   +I  L+ E  +    + A  
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763

Query: 757  SLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR-KTNESDSD----- 810
              +     + +   +ELA + S+  +N    E+  + L R+N+ LR K +E +       
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKN----ESARQQLERQNKELRSKLHEMEGAVKSKF 1819

Query: 811  -----ALRIKCKIIDDQTETIRKLKDC----LQEKDEHIKRLQEKITEIEKCTQ---EQL 858
                 AL  K   +++Q E   + K      L++KD+ +K +  ++ +  K  +   EQ 
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879

Query: 859  DEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 906
            ++ ++++ ++  +LE   E  +++    +  + EL+E  ++   + R+
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 49/200 (24%), Positives = 99/200 (49%), Gaps = 8/200 (4%)

Query: 828  KLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLK 887
            K+K  LQ   +  + +Q K  E++K T+E+  +  ++L E+ +K  +  E K  L++QL+
Sbjct: 847  KVKPLLQVTRQE-EEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 904

Query: 888  GKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQK 947
             +     E  +    L  K  +  E+L  +E +++E     E++ ++L+AER K  +   
Sbjct: 905  AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRGQQLQAERKKMAQQML 960

Query: 948  NAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEET 1007
            +  E+L   ++A ++++       +A+I +L +E    +D  N K+ +  K + E + + 
Sbjct: 961  DLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERISDL 1018

Query: 1008 CKNKKTMEAKIKQLAFALNE 1027
              N    E K K L    N+
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNK 1038


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  108 bits (270), Expect = 3e-23
 Identities = 161/798 (20%), Positives = 335/798 (41%), Gaps = 97/798 (12%)

Query: 283  EKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKE 342
            EKN  +  LQ E +L    +++   L      ++ +L +      +  +  E D G + +
Sbjct: 895  EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE-----MEARLEEEEDRGQQLQ 949

Query: 343  CNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQE 402
              RK   +  +  + +  +      K     V+   K+K   L++  +     N  + +E
Sbjct: 950  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--LEDEILVMDDQNNKLSKE 1007

Query: 403  SEKPKTEIIKVDQSHSED-----------NTYQSLVEQLDQEREKRWRAEQAENKLMDYI 451
             +  +  I  +  + +E+           N ++S++ +L+   +K  ++ Q   KL    
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK--- 1064

Query: 452  DELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAK 511
                K   +  D H        ++ E+  +    + +L+  + +L +EI           
Sbjct: 1065 ---RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---------- 1111

Query: 512  DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER 571
             Q+ + LK +R LE  +  ++     ++AA+     + E +      E+  L+T L    
Sbjct: 1112 -QKNNALKKIRELEGHISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTL 1166

Query: 572  EQAQQLHQLLALKEQEH---RKELETREFFTDADFQDALAKEIAKEEKKHEQM--IKEYQ 626
            +      +L A +EQE    +K L+      +A  Q+   K     E+  EQ+   K  +
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226

Query: 627  EKID----VLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATEL----AKSKHALIWA 678
              +D     L ++  DL  E R+ L    +  +  K   E    EL    +  + A    
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285

Query: 679  QRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK---S 735
              K ++  + ++ +T M+ E + K  +++K     ++ LQ+   T E+L E+ +QK   S
Sbjct: 1286 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQKLNVS 1342

Query: 736  IQIELLKHEKV----QLISELAAKESLIFGLRT------ERKVWGHELAQQGSSLAQNRG 785
             ++  L+ E+     QL  E+ AK++L   + T      + K    + A    +L + + 
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402

Query: 786  KLEAQIESLSRENE-------CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDE 838
            + + +IE+L+++ E        L KT       L      +D+Q + +  L+   ++ D+
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462

Query: 839  HI---KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEE 895
             +   K +  K  +     + +  EK ++   +   LE   E KE+L++  K  + E+E+
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522

Query: 896  IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHS 955
            +  +   + +  H+  +    LETQ++E+K + E  E +L+A  D  + L+ N    + +
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN----MQA 1578

Query: 956  MDDAFKRQVDAIVEAHQAEIAQLANE------------KQKCIDSANLKVHQIEKEMREL 1003
            +   F+R + A  E ++ +  QL  +            KQ+ + +A  K  ++E ++++L
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK--KLEGDLKDL 1636

Query: 1004 LEETCKNKKTMEAKIKQL 1021
              +     K  E  IKQL
Sbjct: 1637 ELQADSAIKGREEAIKQL 1654



 Score =  104 bits (259), Expect = 5e-22
 Identities = 136/560 (24%), Positives = 256/560 (45%), Gaps = 70/560 (12%)

Query: 491  VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVE 550
            + V + + E++    EL K K++Q+     L+ LE+   ++  +K   Q    +L  E E
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE---QLQAETE 908

Query: 551  LKASAADREIYLLRTSLHREREQAQQLHQLLA-LKEQEHRKELETREFFTDA----DFQD 605
            L A A +  + L      +++E  + LH++ A L+E+E R +    E    A    D ++
Sbjct: 909  LYAEAEEMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964

Query: 606  ALAKEIAKEEKKH------EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKD 659
             L +E A  +K        E  IK+ +++I V+  Q   L  E ++   +E R    + D
Sbjct: 965  QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEER----ISD 1017

Query: 660  GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AAN 716
               N+A E  K+K+      + +N+  S+I +L   +K+++    E+ KLK++    A++
Sbjct: 1018 LTTNLAEEEEKAKNLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073

Query: 717  LQNQINTLEILIEDDK-QKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGH--EL 773
               QI  L+  I + K Q + + E L+    +L  E+A K +    L+  R++ GH  +L
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN---ALKKIRELEGHISDL 1130

Query: 774  AQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCL 833
             +   S    R K E Q   L  E E L+   E   D+   + ++   + + +  LK  L
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190

Query: 834  QEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVEL 893
               DE  +  + ++ E+ +   + ++E    L E LE+ +R     +K KQ L+ +  +L
Sbjct: 1191 ---DEETRSHEAQVQEMRQKHAQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADL 1243

Query: 894  E-EIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 952
              E+R          H K +L    E QV+E++ K  + E+      DK  +LQ N +E 
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKL----EAQVQELQSKCSDGERARAELNDKVHKLQ-NEVES 1298

Query: 953  LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKK 1012
            +  M +  + +   + +    ++A L+++ Q               + +ELL+E  + K 
Sbjct: 1299 VTGMLNEAEGKAIKLAK----DVASLSSQLQ---------------DTQELLQEETRQKL 1339

Query: 1013 TMEAKIKQLAFALNEIQQDM 1032
             +  K++QL    N +Q  +
Sbjct: 1340 NVSTKLRQLEEERNSLQDQL 1359



 Score =  103 bits (257), Expect = 8e-22
 Identities = 155/730 (21%), Positives = 310/730 (42%), Gaps = 121/730 (16%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKL----MDYIDELHK 456
            +E+   + ++ ++ Q H++    + L EQL+Q +  +   ++ +  L     D   EL  
Sbjct: 1192 EETRSHEAQVQEMRQKHAQ--AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249

Query: 457  HANEKEDIHSLALLTTDRLKEIIFR---ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 513
                K+++         +++E+  +      ++ +L   VHKLQNE++ +T  L +A+ +
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309

Query: 514  QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 573
                 K + +L   L+  + Q+  Q+  + +L   V  K    + E   L+  L  E E 
Sbjct: 1310 AIKLAKDVASLSSQLQ--DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEA 1365

Query: 574  AQQLHQ---LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID 630
             Q L +    L ++  + +K+L+  +F   A   +AL +   + +K+ E + ++Y+EK  
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQ--DF---ASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420

Query: 631  V--------------LSQQYMDLENEFRIALTVEA--RRFQDVKDGFENVATELAKSK-H 673
                           L    +DL+N+ ++   +E   R+F  +    +N++++ A  +  
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480

Query: 674  ALIWAQRKENESSSLIKDL--TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDD 731
            A   A+ KE ++ SL + L      KE+  +  ++ K + E   + ++ +      +E  
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540

Query: 732  KQK-SIQIELLKHEKVQLISELAAKESLIFGLRTERKV----WGHELAQQGSSLAQNRGK 786
            K+    Q+E +K +  +L  EL A E     L    +     +  +L  +     + R +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600

Query: 787  LEAQIESLSRENECLRKTN-------------------ESDS------DALRIKCKIIDD 821
            L+ Q+     E E  RK                     ++DS      +A++   K+   
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660

Query: 822  QTETIRKLKDCLQEKDE-----------------HIKRLQEKITEIEKCTQEQLDEKSSQ 864
              +  R+L+D    +DE                  + +LQE +   E+  ++   EK   
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720

Query: 865  LDEVLEKLERHN---ERKEKLKQQLKGKEVELEEIR---KAYSTLNRKWHDKGELLCHLE 918
             +E+   L   N   + K +L+ ++   E ELEE +   +A S   RK   + E L +  
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 919  TQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQL 978
               +   +K E+  ++L+ +        K    KLH M+ A K +  + + A +A+IAQL
Sbjct: 1781 ATERSTAQKNESARQQLERQN-------KELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833

Query: 979  -------ANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTME----------AKIKQL 1021
                   A EKQ    +A   + Q +K+++E+L +    +K  E          A++KQL
Sbjct: 1834 EEQVEQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889

Query: 1022 AFALNEIQQD 1031
               L E +++
Sbjct: 1890 KRQLEEAEEE 1899



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 141/670 (21%), Positives = 285/670 (42%), Gaps = 84/670 (12%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLV-EQLDQEREKRWRAEQAENKLMDYIDELHKHAN 459
            +  +K + E+ +++Q HS+    ++L+ EQL  E E    AE+   +L     EL     
Sbjct: 873  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL----- 927

Query: 460  EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 519
             +E +H +         E    E   +GQ      +LQ E KK+  +++  ++Q E+   
Sbjct: 928  -EEILHEM---------EARLEEEEDRGQ------QLQAERKKMAQQMLDLEEQLEEEEA 971

Query: 520  HLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADRE-----IYLLRTSLHREREQA 574
              + L+  LEK+  + + ++     L+ + +    + +R+     I  L T+L  E E+A
Sbjct: 972  ARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029

Query: 575  QQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ 634
            + L + L  K +    ELE R        ++   +E+ K ++K E    ++ E+I  L  
Sbjct: 1030 KNLTK-LKNKHESMISELEVR-----LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083

Query: 635  QYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTC 694
            Q  +L+ +        A++ ++++     +  E+A+  +AL   +  E   S L +DL  
Sbjct: 1084 QIAELKMQL-------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136

Query: 695  ------MVKEQKTKLAE--------------VSKLKQETAANLQNQINTL-EILIEDDKQ 733
                    ++QK  L E               +  +QE  A  + ++  L + L E+ + 
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196

Query: 734  KSIQIELLKHEKVQLISELA--------AKESLIFGLRTERKVWG------HELAQQGSS 779
               Q++ ++ +  Q + EL         AK +L    +T  K           L Q    
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256

Query: 780  LAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEH 839
            +   + KLEAQ++ L  +++C     E     L  K   + ++ E++  + +  + K   
Sbjct: 1257 VEHKKKKLEAQVQEL--QSKC--SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312

Query: 840  IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 899
            + +    ++   + TQE L E++ Q   V  KL +  E +  L+ QL  +    + + + 
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372

Query: 900  YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 959
             STLN +  D  + L    + V+ ++E  +  +K+++    +  E +  A +KL    + 
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKNR 1431

Query: 960  FKRQVDAIVE--AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 1017
             ++++D +V    +Q ++     +KQ+  D    +   I  +  +  +      +  E K
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491

Query: 1018 IKQLAFALNE 1027
               LA AL E
Sbjct: 1492 ALSLARALEE 1501



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 133/609 (21%), Positives = 261/609 (42%), Gaps = 82/609 (13%)

Query: 399  MLQESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQ-----------AENK 446
            +LQE  + K  +  K+ Q   E N   SL +QLD+E E +   E+           ++ K
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 447  LMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVE 506
            L D+   +      K+         T + +E    +  +  +LE   ++LQ E+  L V+
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEE----KAAAYDKLEKTKNRLQQELDDLVVD 1442

Query: 507  LMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS 566
            L       ++  + +  LEK   K ++   +++    +   E + +A A  RE      S
Sbjct: 1443 L-------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD-RAEAEAREKETKALS 1494

Query: 567  LHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQ 626
            L R  E+A +  + L    +  + E+E  +  +  D       E+ K ++  E  ++E +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552

Query: 627  EKIDVLSQQYMDLEN-EFRIALTVEARRFQDVKD-----------------GFENVATEL 668
             +++ L  +    E+ + R+ + ++A + Q  +D                       TEL
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612

Query: 669  A--KSKHALIWAQRKENESSSLIKDLTCM----VKEQKTKLAEVSKLK---QETAANLQN 719
               + + AL  A +K+ E    +KDL       +K ++  + ++ KL+   ++    L++
Sbjct: 1613 EDERKQRALAAAAKKKLEGD--LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670

Query: 720  QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGS- 778
               + + +    K+   + + L+ + +QL  +LAA E        E++    ELA   S 
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 779  --SLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDD-------QTETIRKL 829
              +L   + +LEA+I  L  E E  +   E+ SD +R   +  +        +  T +K 
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 830  KDCLQEKDEHIKRLQEKITEIE-------KCTQEQLDEKSSQLDEVLEKLERHNERKEK- 881
            +   Q+ +   K L+ K+ E+E       K T   L+ K +QL+E +E+  R  +   K 
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 882  LKQQ---LKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFEN---KEKKL 935
            LKQ+   LK   +++E+ RK       +       +  L+ Q++E +E+ +      +KL
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910

Query: 936  KAERDKSIE 944
            + E D++ E
Sbjct: 1911 QRELDEATE 1919



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 96/457 (21%), Positives = 203/457 (44%), Gaps = 61/457 (13%)

Query: 580  LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE---YQEKIDVLSQQY 636
            LL +  QE   + +  E     + Q     E+ + E+KH Q+ +E    QE++   ++ Y
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 637  MDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 696
             + E E R+ L  + +  +++    E    E  + +   + A+RK+     L  DL   +
Sbjct: 911  AEAE-EMRVRLAAKKQELEEILHEME-ARLEEEEDRGQQLQAERKKMAQQML--DLEEQL 966

Query: 697  KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIE--LLKHEKVQLISELAA 754
            +E++    ++   K    A ++   +  EIL+ DD+   +  E  LL+     L + LA 
Sbjct: 967  EEEEAARQKLQLEKVTAEAKIKKLED--EILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024

Query: 755  KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC-LRKTNESDSDALR 813
            +E                        A+N  KL+ + ES+  E E  L+K  +S  +  +
Sbjct: 1025 EE----------------------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062

Query: 814  IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE 873
            +K K+  D ++   ++ D LQ +   +K    K  E  +    +LD++ +Q +  L+K+ 
Sbjct: 1063 LKRKLEGDASDFHEQIAD-LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI- 1120

Query: 874  RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 933
                   +L+  +   + +L+  R A +   ++  D GE L  L+T++++  +     ++
Sbjct: 1121 ------RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQ 1173

Query: 934  KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 993
            +L+A+R++ + + K A+              D    +H+A++ ++  +  + ++    ++
Sbjct: 1174 ELRAKREQEVTVLKKAL--------------DEETRSHEAQVQEMRQKHAQAVEELTEQL 1219

Query: 994  HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 1030
             Q ++    L     KNK+T+E +   LA  L  + Q
Sbjct: 1220 EQFKRAKANL----DKNKQTLEKENADLAGELRVLGQ 1252



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 138/648 (21%), Positives = 280/648 (43%), Gaps = 83/648 (12%)

Query: 291  LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 350
            LQ E + +      L+ L E  NS+ + L+++   K++ +    S    +   ++K    
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSDSKK---- 1385

Query: 351  SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEI 410
             K+   A T++ ++   K +   +          L + Y   + A      + EK K  +
Sbjct: 1386 -KLQDFASTVEALEEGKKRFQKEIE--------NLTQQYEEKAAA----YDKLEKTKNRL 1432

Query: 411  IK-VDQSHSEDNTYQSLVEQLDQEREK--RWRAEQAE--NKLMDYIDELHKHANEKED-I 464
             + +D    + +  + LV  L++++ K  +  AE+    +K  D  D     A EKE   
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492

Query: 465  HSLALLTTDRLKEIIFRERNSK---GQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHL 521
             SLA    + L+     ER +K    ++E +V   ++++ K   EL K+K   E  ++ +
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEM 1551

Query: 522  RTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL 581
            +T    LE++E + +  + A++RL  EV ++A     E       L    EQ ++  + L
Sbjct: 1552 KT---QLEELEDELQATEDAKLRL--EVNMQALKGQFE-----RDLQARDEQNEEKRRQL 1601

Query: 582  ALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLEN 641
              +  E+  ELE      D   Q ALA   A  +KK E  +K+ + + D   +   +   
Sbjct: 1602 QRQLHEYETELE------DERKQRALA---AAAKKKLEGDLKDLELQADSAIKGREEAIK 1652

Query: 642  EFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKT 701
            + R  L  + + FQ           E A++    I+A  KENE  +   +   M  ++  
Sbjct: 1653 QLR-KLQAQMKDFQR--------ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 702  KLAEVSKL-----KQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 756
              AE ++      K+E A  L + ++    L ++ ++   +I  L+ E  +    + A  
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763

Query: 757  SLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR-KTNESDSD----- 810
              +     + +   +ELA + S+  +N    E+  + L R+N+ LR K +E +       
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKN----ESARQQLERQNKELRSKLHEMEGAVKSKF 1819

Query: 811  -----ALRIKCKIIDDQTETIRKLKDC----LQEKDEHIKRLQEKITEIEKCTQ---EQL 858
                 AL  K   +++Q E   + K      L++KD+ +K +  ++ +  K  +   EQ 
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879

Query: 859  DEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 906
            ++ ++++ ++  +LE   E  +++    +  + EL+E  ++   + R+
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 49/200 (24%), Positives = 99/200 (49%), Gaps = 8/200 (4%)

Query: 828  KLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLK 887
            K+K  LQ   +  + +Q K  E++K T+E+  +  ++L E+ +K  +  E K  L++QL+
Sbjct: 847  KVKPLLQVTRQE-EEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 904

Query: 888  GKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQK 947
             +     E  +    L  K  +  E+L  +E +++E     E++ ++L+AER K  +   
Sbjct: 905  AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRGQQLQAERKKMAQQML 960

Query: 948  NAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEET 1007
            +  E+L   ++A ++++       +A+I +L +E    +D  N K+ +  K + E + + 
Sbjct: 961  DLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERISDL 1018

Query: 1008 CKNKKTMEAKIKQLAFALNE 1027
              N    E K K L    N+
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNK 1038


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  108 bits (270), Expect = 3e-23
 Identities = 161/798 (20%), Positives = 335/798 (41%), Gaps = 97/798 (12%)

Query: 283  EKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKE 342
            EKN  +  LQ E +L    +++   L      ++ +L +      +  +  E D G + +
Sbjct: 888  EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE-----MEARLEEEEDRGQQLQ 942

Query: 343  CNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQE 402
              RK   +  +  + +  +      K     V+   K+K   L++  +     N  + +E
Sbjct: 943  AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--LEDEILVMDDQNNKLSKE 1000

Query: 403  SEKPKTEIIKVDQSHSED-----------NTYQSLVEQLDQEREKRWRAEQAENKLMDYI 451
             +  +  I  +  + +E+           N ++S++ +L+   +K  ++ Q   KL    
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK--- 1057

Query: 452  DELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAK 511
                K   +  D H        ++ E+  +    + +L+  + +L +EI           
Sbjct: 1058 ---RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---------- 1104

Query: 512  DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER 571
             Q+ + LK +R LE  +  ++     ++AA+     + E +      E+  L+T L    
Sbjct: 1105 -QKNNALKKIRELEGHISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTL 1159

Query: 572  EQAQQLHQLLALKEQEH---RKELETREFFTDADFQDALAKEIAKEEKKHEQM--IKEYQ 626
            +      +L A +EQE    +K L+      +A  Q+   K     E+  EQ+   K  +
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219

Query: 627  EKID----VLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATEL----AKSKHALIWA 678
              +D     L ++  DL  E R+ L    +  +  K   E    EL    +  + A    
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278

Query: 679  QRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK---S 735
              K ++  + ++ +T M+ E + K  +++K     ++ LQ+   T E+L E+ +QK   S
Sbjct: 1279 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQKLNVS 1335

Query: 736  IQIELLKHEKV----QLISELAAKESLIFGLRT------ERKVWGHELAQQGSSLAQNRG 785
             ++  L+ E+     QL  E+ AK++L   + T      + K    + A    +L + + 
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395

Query: 786  KLEAQIESLSRENE-------CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDE 838
            + + +IE+L+++ E        L KT       L      +D+Q + +  L+   ++ D+
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455

Query: 839  HI---KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEE 895
             +   K +  K  +     + +  EK ++   +   LE   E KE+L++  K  + E+E+
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515

Query: 896  IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHS 955
            +  +   + +  H+  +    LETQ++E+K + E  E +L+A  D  + L+ N    + +
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN----MQA 1571

Query: 956  MDDAFKRQVDAIVEAHQAEIAQLANE------------KQKCIDSANLKVHQIEKEMREL 1003
            +   F+R + A  E ++ +  QL  +            KQ+ + +A  K  ++E ++++L
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK--KLEGDLKDL 1629

Query: 1004 LEETCKNKKTMEAKIKQL 1021
              +     K  E  IKQL
Sbjct: 1630 ELQADSAIKGREEAIKQL 1647



 Score =  104 bits (259), Expect = 5e-22
 Identities = 136/560 (24%), Positives = 256/560 (45%), Gaps = 70/560 (12%)

Query: 491  VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVE 550
            + V + + E++    EL K K++Q+     L+ LE+   ++  +K   Q    +L  E E
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE---QLQAETE 901

Query: 551  LKASAADREIYLLRTSLHREREQAQQLHQLLA-LKEQEHRKELETREFFTDA----DFQD 605
            L A A +  + L      +++E  + LH++ A L+E+E R +    E    A    D ++
Sbjct: 902  LYAEAEEMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957

Query: 606  ALAKEIAKEEKKH------EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKD 659
             L +E A  +K        E  IK+ +++I V+  Q   L  E ++   +E R    + D
Sbjct: 958  QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEER----ISD 1010

Query: 660  GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AAN 716
               N+A E  K+K+      + +N+  S+I +L   +K+++    E+ KLK++    A++
Sbjct: 1011 LTTNLAEEEEKAKNLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066

Query: 717  LQNQINTLEILIEDDK-QKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGH--EL 773
               QI  L+  I + K Q + + E L+    +L  E+A K +    L+  R++ GH  +L
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN---ALKKIRELEGHISDL 1123

Query: 774  AQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCL 833
             +   S    R K E Q   L  E E L+   E   D+   + ++   + + +  LK  L
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183

Query: 834  QEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVEL 893
               DE  +  + ++ E+ +   + ++E    L E LE+ +R     +K KQ L+ +  +L
Sbjct: 1184 ---DEETRSHEAQVQEMRQKHAQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADL 1236

Query: 894  E-EIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 952
              E+R          H K +L    E QV+E++ K  + E+      DK  +LQ N +E 
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKL----EAQVQELQSKCSDGERARAELNDKVHKLQ-NEVES 1291

Query: 953  LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKK 1012
            +  M +  + +   + +    ++A L+++ Q               + +ELL+E  + K 
Sbjct: 1292 VTGMLNEAEGKAIKLAK----DVASLSSQLQ---------------DTQELLQEETRQKL 1332

Query: 1013 TMEAKIKQLAFALNEIQQDM 1032
             +  K++QL    N +Q  +
Sbjct: 1333 NVSTKLRQLEEERNSLQDQL 1352



 Score =  103 bits (257), Expect = 8e-22
 Identities = 155/730 (21%), Positives = 310/730 (42%), Gaps = 121/730 (16%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKL----MDYIDELHK 456
            +E+   + ++ ++ Q H++    + L EQL+Q +  +   ++ +  L     D   EL  
Sbjct: 1185 EETRSHEAQVQEMRQKHAQ--AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242

Query: 457  HANEKEDIHSLALLTTDRLKEIIFR---ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 513
                K+++         +++E+  +      ++ +L   VHKLQNE++ +T  L +A+ +
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302

Query: 514  QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 573
                 K + +L   L+  + Q+  Q+  + +L   V  K    + E   L+  L  E E 
Sbjct: 1303 AIKLAKDVASLSSQLQ--DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEA 1358

Query: 574  AQQLHQ---LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID 630
             Q L +    L ++  + +K+L+  +F   A   +AL +   + +K+ E + ++Y+EK  
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQ--DF---ASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413

Query: 631  V--------------LSQQYMDLENEFRIALTVEA--RRFQDVKDGFENVATELAKSK-H 673
                           L    +DL+N+ ++   +E   R+F  +    +N++++ A  +  
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473

Query: 674  ALIWAQRKENESSSLIKDL--TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDD 731
            A   A+ KE ++ SL + L      KE+  +  ++ K + E   + ++ +      +E  
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533

Query: 732  KQK-SIQIELLKHEKVQLISELAAKESLIFGLRTERKV----WGHELAQQGSSLAQNRGK 786
            K+    Q+E +K +  +L  EL A E     L    +     +  +L  +     + R +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593

Query: 787  LEAQIESLSRENECLRKTN-------------------ESDS------DALRIKCKIIDD 821
            L+ Q+     E E  RK                     ++DS      +A++   K+   
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653

Query: 822  QTETIRKLKDCLQEKDE-----------------HIKRLQEKITEIEKCTQEQLDEKSSQ 864
              +  R+L+D    +DE                  + +LQE +   E+  ++   EK   
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713

Query: 865  LDEVLEKLERHN---ERKEKLKQQLKGKEVELEEIR---KAYSTLNRKWHDKGELLCHLE 918
             +E+   L   N   + K +L+ ++   E ELEE +   +A S   RK   + E L +  
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 919  TQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQL 978
               +   +K E+  ++L+ +        K    KLH M+ A K +  + + A +A+IAQL
Sbjct: 1774 ATERSTAQKNESARQQLERQN-------KELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826

Query: 979  -------ANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTME----------AKIKQL 1021
                   A EKQ    +A   + Q +K+++E+L +    +K  E          A++KQL
Sbjct: 1827 EEQVEQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882

Query: 1022 AFALNEIQQD 1031
               L E +++
Sbjct: 1883 KRQLEEAEEE 1892



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 141/670 (21%), Positives = 285/670 (42%), Gaps = 84/670 (12%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLV-EQLDQEREKRWRAEQAENKLMDYIDELHKHAN 459
            +  +K + E+ +++Q HS+    ++L+ EQL  E E    AE+   +L     EL     
Sbjct: 866  ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL----- 920

Query: 460  EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 519
             +E +H +         E    E   +GQ      +LQ E KK+  +++  ++Q E+   
Sbjct: 921  -EEILHEM---------EARLEEEEDRGQ------QLQAERKKMAQQMLDLEEQLEEEEA 964

Query: 520  HLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADRE-----IYLLRTSLHREREQA 574
              + L+  LEK+  + + ++     L+ + +    + +R+     I  L T+L  E E+A
Sbjct: 965  ARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022

Query: 575  QQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ 634
            + L + L  K +    ELE R        ++   +E+ K ++K E    ++ E+I  L  
Sbjct: 1023 KNLTK-LKNKHESMISELEVR-----LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076

Query: 635  QYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTC 694
            Q  +L+ +        A++ ++++     +  E+A+  +AL   +  E   S L +DL  
Sbjct: 1077 QIAELKMQL-------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129

Query: 695  ------MVKEQKTKLAE--------------VSKLKQETAANLQNQINTL-EILIEDDKQ 733
                    ++QK  L E               +  +QE  A  + ++  L + L E+ + 
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189

Query: 734  KSIQIELLKHEKVQLISELA--------AKESLIFGLRTERKVWG------HELAQQGSS 779
               Q++ ++ +  Q + EL         AK +L    +T  K           L Q    
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249

Query: 780  LAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEH 839
            +   + KLEAQ++ L  +++C     E     L  K   + ++ E++  + +  + K   
Sbjct: 1250 VEHKKKKLEAQVQEL--QSKC--SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305

Query: 840  IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 899
            + +    ++   + TQE L E++ Q   V  KL +  E +  L+ QL  +    + + + 
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365

Query: 900  YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 959
             STLN +  D  + L    + V+ ++E  +  +K+++    +  E +  A +KL    + 
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKNR 1424

Query: 960  FKRQVDAIVE--AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 1017
             ++++D +V    +Q ++     +KQ+  D    +   I  +  +  +      +  E K
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484

Query: 1018 IKQLAFALNE 1027
               LA AL E
Sbjct: 1485 ALSLARALEE 1494



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 133/609 (21%), Positives = 261/609 (42%), Gaps = 82/609 (13%)

Query: 399  MLQESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQ-----------AENK 446
            +LQE  + K  +  K+ Q   E N   SL +QLD+E E +   E+           ++ K
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 447  LMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVE 506
            L D+   +      K+         T + +E    +  +  +LE   ++LQ E+  L V+
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEE----KAAAYDKLEKTKNRLQQELDDLVVD 1435

Query: 507  LMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS 566
            L       ++  + +  LEK   K ++   +++    +   E + +A A  RE      S
Sbjct: 1436 L-------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD-RAEAEAREKETKALS 1487

Query: 567  LHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQ 626
            L R  E+A +  + L    +  + E+E  +  +  D       E+ K ++  E  ++E +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545

Query: 627  EKIDVLSQQYMDLEN-EFRIALTVEARRFQDVKD-----------------GFENVATEL 668
             +++ L  +    E+ + R+ + ++A + Q  +D                       TEL
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605

Query: 669  A--KSKHALIWAQRKENESSSLIKDLTCM----VKEQKTKLAEVSKLK---QETAANLQN 719
               + + AL  A +K+ E    +KDL       +K ++  + ++ KL+   ++    L++
Sbjct: 1606 EDERKQRALAAAAKKKLEGD--LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663

Query: 720  QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGS- 778
               + + +    K+   + + L+ + +QL  +LAA E        E++    ELA   S 
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 779  --SLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDD-------QTETIRKL 829
              +L   + +LEA+I  L  E E  +   E+ SD +R   +  +        +  T +K 
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 830  KDCLQEKDEHIKRLQEKITEIE-------KCTQEQLDEKSSQLDEVLEKLERHNERKEK- 881
            +   Q+ +   K L+ K+ E+E       K T   L+ K +QL+E +E+  R  +   K 
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 882  LKQQ---LKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFEN---KEKKL 935
            LKQ+   LK   +++E+ RK       +       +  L+ Q++E +E+ +      +KL
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903

Query: 936  KAERDKSIE 944
            + E D++ E
Sbjct: 1904 QRELDEATE 1912



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 96/457 (21%), Positives = 203/457 (44%), Gaps = 61/457 (13%)

Query: 580  LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE---YQEKIDVLSQQY 636
            LL +  QE   + +  E     + Q     E+ + E+KH Q+ +E    QE++   ++ Y
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 637  MDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 696
             + E E R+ L  + +  +++    E    E  + +   + A+RK+     L  DL   +
Sbjct: 904  AEAE-EMRVRLAAKKQELEEILHEME-ARLEEEEDRGQQLQAERKKMAQQML--DLEEQL 959

Query: 697  KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIE--LLKHEKVQLISELAA 754
            +E++    ++   K    A ++   +  EIL+ DD+   +  E  LL+     L + LA 
Sbjct: 960  EEEEAARQKLQLEKVTAEAKIKKLED--EILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017

Query: 755  KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC-LRKTNESDSDALR 813
            +E                        A+N  KL+ + ES+  E E  L+K  +S  +  +
Sbjct: 1018 EE----------------------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055

Query: 814  IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE 873
            +K K+  D ++   ++ D LQ +   +K    K  E  +    +LD++ +Q +  L+K+ 
Sbjct: 1056 LKRKLEGDASDFHEQIAD-LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI- 1113

Query: 874  RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 933
                   +L+  +   + +L+  R A +   ++  D GE L  L+T++++  +     ++
Sbjct: 1114 ------RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQ 1166

Query: 934  KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 993
            +L+A+R++ + + K A+              D    +H+A++ ++  +  + ++    ++
Sbjct: 1167 ELRAKREQEVTVLKKAL--------------DEETRSHEAQVQEMRQKHAQAVEELTEQL 1212

Query: 994  HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 1030
             Q ++    L     KNK+T+E +   LA  L  + Q
Sbjct: 1213 EQFKRAKANL----DKNKQTLEKENADLAGELRVLGQ 1245



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 138/648 (21%), Positives = 280/648 (43%), Gaps = 83/648 (12%)

Query: 291  LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 350
            LQ E + +      L+ L E  NS+ + L+++   K++ +    S    +   ++K    
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSDSKK---- 1378

Query: 351  SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEI 410
             K+   A T++ ++   K +   +          L + Y   + A      + EK K  +
Sbjct: 1379 -KLQDFASTVEALEEGKKRFQKEIE--------NLTQQYEEKAAA----YDKLEKTKNRL 1425

Query: 411  IK-VDQSHSEDNTYQSLVEQLDQEREK--RWRAEQAE--NKLMDYIDELHKHANEKED-I 464
             + +D    + +  + LV  L++++ K  +  AE+    +K  D  D     A EKE   
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485

Query: 465  HSLALLTTDRLKEIIFRERNSK---GQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHL 521
             SLA    + L+     ER +K    ++E +V   ++++ K   EL K+K   E  ++ +
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEM 1544

Query: 522  RTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL 581
            +T    LE++E + +  + A++RL  EV ++A     E       L    EQ ++  + L
Sbjct: 1545 KT---QLEELEDELQATEDAKLRL--EVNMQALKGQFE-----RDLQARDEQNEEKRRQL 1594

Query: 582  ALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLEN 641
              +  E+  ELE      D   Q ALA   A  +KK E  +K+ + + D   +   +   
Sbjct: 1595 QRQLHEYETELE------DERKQRALA---AAAKKKLEGDLKDLELQADSAIKGREEAIK 1645

Query: 642  EFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKT 701
            + R  L  + + FQ           E A++    I+A  KENE  +   +   M  ++  
Sbjct: 1646 QLR-KLQAQMKDFQR--------ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 702  KLAEVSKL-----KQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 756
              AE ++      K+E A  L + ++    L ++ ++   +I  L+ E  +    + A  
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756

Query: 757  SLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR-KTNESDSD----- 810
              +     + +   +ELA + S+  +N    E+  + L R+N+ LR K +E +       
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKN----ESARQQLERQNKELRSKLHEMEGAVKSKF 1812

Query: 811  -----ALRIKCKIIDDQTETIRKLKDC----LQEKDEHIKRLQEKITEIEKCTQ---EQL 858
                 AL  K   +++Q E   + K      L++KD+ +K +  ++ +  K  +   EQ 
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872

Query: 859  DEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 906
            ++ ++++ ++  +LE   E  +++    +  + EL+E  ++   + R+
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 49/200 (24%), Positives = 99/200 (49%), Gaps = 8/200 (4%)

Query: 828  KLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLK 887
            K+K  LQ   +  + +Q K  E++K T+E+  +  ++L E+ +K  +  E K  L++QL+
Sbjct: 840  KVKPLLQVTRQE-EEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 897

Query: 888  GKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQK 947
             +     E  +    L  K  +  E+L  +E +++E     E++ ++L+AER K  +   
Sbjct: 898  AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRGQQLQAERKKMAQQML 953

Query: 948  NAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEET 1007
            +  E+L   ++A ++++       +A+I +L +E    +D  N K+ +  K + E + + 
Sbjct: 954  DLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERISDL 1011

Query: 1008 CKNKKTMEAKIKQLAFALNE 1027
              N    E K K L    N+
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNK 1031


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  108 bits (269), Expect = 3e-23
 Identities = 166/813 (20%), Positives = 335/813 (41%), Gaps = 158/813 (19%)

Query: 340  RKECNRKVPRRSKI---PYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLAN 396
            R E  + + RR  I    Y+ +    +KH       ++    K+KP  LK       +AN
Sbjct: 802  RVEFRKMMERRESIFCIQYNIRAFMNVKHW-----PWMKLYFKIKP-LLKSAETEKEMAN 855

Query: 397  CPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHK 456
              M +E EK K E+ K +    E    + +V  + ++ + + + +   + L D  +   +
Sbjct: 856  --MKEEFEKTKEELAKTEAKRKE--LEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQ 911

Query: 457  HANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLT-----VELMKAK 511
                K  + +     T+R ++    E     +L     KL++E  +L      +EL  AK
Sbjct: 912  LIKTKIQLEAKIKEVTERAED----EEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967

Query: 512  DQQEDHL---------KHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA------ 556
             ++E H          + +  L++T+ K+ ++K+  Q A  + + +++++          
Sbjct: 968  VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKA 1027

Query: 557  ----DREIYLLRTSLHREREQAQQLHQLLA----------------------LKEQEHRK 590
                ++++  L  SL +E++    L +                         L E+  +K
Sbjct: 1028 KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKK 1087

Query: 591  ELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDV-------LSQQYMDLENEF 643
            E E        + + ALA ++ K+ K+ +  I+E +E+I+          +Q  DL  E 
Sbjct: 1088 EFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147

Query: 644  RIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCM-------- 695
                  E     +   G  +   E+ K + A     R++ E S+L  + T          
Sbjct: 1148 E-----EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202

Query: 696  ----VKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELL---------- 741
                + EQ   L  V +  ++  + L+ +IN L   +E   +     E +          
Sbjct: 1203 SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSE 1262

Query: 742  ----KHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQ-NRGK--LEAQIESL 794
                + E+ +LI+EL+A+++    L TE   +  +L ++ + ++Q +RGK     QIE L
Sbjct: 1263 IKTKEEEQQRLINELSAQKAR---LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEEL 1319

Query: 795  SRENECLRKTNESDSDAL---RIKCKIIDDQTETIRKLKDCLQE---------------- 835
             R+ E   K   + + AL   R  C ++ +Q E  ++ K  LQ                 
Sbjct: 1320 KRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKY 1379

Query: 836  KDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEE 895
            + + I+R +E + E +K   ++L +    ++ V  K     + K++L+ +++   +++E 
Sbjct: 1380 ETDAIQRTEE-LEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVER 1438

Query: 896  IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQ------KNA 949
               A   L++K  +  ++L        E K+K+E  + +L+A + +S  L       KNA
Sbjct: 1439 SNAACIALDKKQRNFDKVLA-------EWKQKYEETQAELEASQKESRSLSTELFKVKNA 1491

Query: 950  MEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEK----------E 999
             E+     +  KR+   +    Q EI+ L  +    I      +H++EK          E
Sbjct: 1492 YEESLDHLETLKRENKNL----QQEISDLTEQ----IAEGGKHIHELEKVKKQLDHEKSE 1543

Query: 1000 MRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 1032
            ++  LEE   + +  E KI ++   LN+++ ++
Sbjct: 1544 LQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 135/630 (21%), Positives = 271/630 (43%), Gaps = 84/630 (13%)

Query: 387  ELYVSSSLANCPMLQESEKPKTEIIKVDQSHSEDNT-----YQSLVEQLDQEREKRWRAE 441
            EL    S AN  + Q   K +T+ I+  +   E         Q   E ++    K    E
Sbjct: 1360 ELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLE 1419

Query: 442  QAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSK-GQLEVMVHKLQNEI 500
            + + +L + +++L     E+ +   +AL    R  + +  E   K  + +  +   Q E 
Sbjct: 1420 KTKQRLQNEVEDLMIDV-ERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKES 1478

Query: 501  KKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ---KRQQQAAQIRLIQEVELKASAAD 557
            + L+ EL K K+  E+ L HL TL++  + ++++     +Q A   + I E+E      D
Sbjct: 1479 RSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLD 1538

Query: 558  REIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKK 617
             E   L+TSL    E+A+      A  E E  K L              +  E+ + + +
Sbjct: 1539 HEKSELQTSL----EEAE------ASLEHEEGKILR-------------IQLELNQVKSE 1575

Query: 618  HEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIW 677
             ++ I E  E++D L + ++ +    +  L  E R   D     + +  +L + +  L  
Sbjct: 1576 IDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNH 1635

Query: 678  AQRKENESSSLIKDLTCMVKEQKTKLAEVSKLK---QETAANLQNQINTLEILIEDDKQK 734
            A R+  E+   +++   ++K+ +  L +  + +   +E  A ++ + N ++  +E+ +  
Sbjct: 1636 ANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRAS 1695

Query: 735  SIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESL 794
                     E+ +   ++A +E L    R +       L  Q +SL   + KLE  I  +
Sbjct: 1696 L--------ERTERGRKMAEQELLDASERVQL------LHTQNTSLINTKKKLETDISQI 1741

Query: 795  SRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCT 854
              E E + +   +  +  +   K I D      +LK   Q+   H++R+++ + +  K  
Sbjct: 1742 QGEMEDIVQEARNAEEKAK---KAITDAAMMAEELKK-EQDTSAHLERMKKNMEQTVKDL 1797

Query: 855  QEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELL 914
            Q +LDE + QL      L+   ++ +KL+ +++  E E+E  +K                
Sbjct: 1798 QLRLDE-AEQL-----ALKGGKKQIQKLEARVRELESEVESEQK---------------- 1835

Query: 915  CHLETQVKEVKEKFENKEKKL--KAERD-KSIELQKNAMEKLHSMDDAFKRQVDAIVEAH 971
             H    VK ++ K E + K+L  + E D K+I   ++ ++KL +   A+KRQ +   E  
Sbjct: 1836 -HNVEAVKGLR-KHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQS 1893

Query: 972  QAEIA---QLANEKQKCIDSANLKVHQIEK 998
               +A   +L +E ++  + A++   Q+ K
Sbjct: 1894 NVNLAKFRKLQHELEEAKERADIAESQVNK 1923



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 110/588 (18%), Positives = 254/588 (43%), Gaps = 52/588 (8%)

Query: 389  YVSSSLANCPMLQESEKPKTEIIKVDQSHSE---------DNTYQSL---VEQLDQEREK 436
            Y + ++     L+E++K   + ++  + H E         + T Q L   VE L  + E+
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVER 1438

Query: 437  RWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR----LKEIIFRERNSKGQLEVM 492
               A  A +K     D++     +K +     L  + +    L   +F+ +N+  +    
Sbjct: 1439 SNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDH 1498

Query: 493  VHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELK 552
            +  L+ E K L  E+    +Q  +  KH+  LEK  ++++ +K + Q +    ++E E  
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTS----LEEAEAS 1554

Query: 553  ASAADREIYLLRTSLHR-----EREQAQQLHQLLALKEQEHRKELETREFFTDADFQDAL 607
                + +I  ++  L++     +R+ A++  +L  LK + H + +E+ +   DA+ +   
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLK-RNHLRVVESMQSTLDAEIRS-- 1611

Query: 608  AKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATE 667
              +  + +KK E  + E + +++  ++Q  +     R    +     +D +   ++    
Sbjct: 1612 RNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGI----LKDTQLHLDDAIRG 1667

Query: 668  LAKSKHALIWAQRKENESSSLIKDLTCMVK--EQKTKLAEVSKLKQETAANLQNQINTLE 725
                K  L   +R+ N   + +++L   ++  E+  K+AE   L       L +  NT  
Sbjct: 1668 QDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNT-- 1725

Query: 726  ILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRG 785
             LI   K+    I  ++ E   ++ E    E       T+  +   EL ++  + A    
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH--- 1782

Query: 786  KLEAQIESLSRENECLR-KTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQ 844
             LE   +++ +  + L+ + +E++  AL+   K I      +R+L+  ++ + +H     
Sbjct: 1783 -LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAV 1841

Query: 845  EKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLN 904
            + + + E+    ++ E + Q +E  + + R  +  +KL+ ++K  + + EE  +  +   
Sbjct: 1842 KGLRKHER----RVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL 1897

Query: 905  RKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 952
             K+         L+ +++E KE+ +  E ++   R KS E+    + +
Sbjct: 1898 AKFR-------KLQHELEEAKERADIAESQVNKLRVKSREVHTKVISE 1938


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  105 bits (262), Expect = 2e-22
 Identities = 163/776 (21%), Positives = 326/776 (42%), Gaps = 100/776 (12%)

Query: 292  QNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRS 351
            ++E K ++L+++++ LL E      N L+   + + D+   +E      + C + +  + 
Sbjct: 868  KSEAKRKELEEKMVTLLKEK-----NDLQLQVQSEADSLADAE------ERCEQLIKNKI 916

Query: 352  KIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEII 411
            ++    K +       +  N+ ++  ++       EL            ++ +  +  + 
Sbjct: 917  QLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELK-----------KDIDDLELTLA 965

Query: 412  KVD-QSHSEDNTYQSLVEQ---LDQEREKRWRAEQA-ENKLMDYIDELHKHANEKEDIHS 466
            KV+ + H+ +N  ++L E+   LD+   K  + ++A +      +D+L     E++ ++ 
Sbjct: 966  KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQA---EEDKVNI 1022

Query: 467  LALLTT------DRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKH 520
            L    T      D L+  + +E+  +  LE    KL+ ++K      M  ++ ++   + 
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082

Query: 521  LRTLEKTLEKMERQKRQQQAAQIRL---IQEVELKASAADREIYLLRTSLHREREQAQQL 577
            L   E  +  +  +   +QA +I+L   I+E++ +      EI   R S  +  +Q   L
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL 1142

Query: 578  HQLL---------------ALKEQEHRKELETREFFTDADFQDALAKE--IAKEEKKHEQ 620
             + L               A  E   ++E E ++   D + +  L  E  +A   KKH  
Sbjct: 1143 SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLE-EATLQHEAMVAALRKKHAD 1201

Query: 621  MIKEYQEKIDVLSQQYMDLENEFRIA------LTVEARRFQDVKDGFENVATELAKSKHA 674
             + E  E+ID L +    LE E          L+  A      K   E +   L      
Sbjct: 1202 SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSE 1261

Query: 675  LIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK 734
            L   + KE E   LI DLT      +T+  E S+   E  A L +Q++         KQ 
Sbjct: 1262 L---KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDA-LVSQLSR-------SKQA 1310

Query: 735  SIQ-IELLKHEKVQLISELAAKESLIFGLRTERKVWGHE---LAQQGSSLAQNRGKLEAQ 790
            S Q IE LKH   QL  E  AK +L   L++ R    H+   L +Q     +  GK E Q
Sbjct: 1311 STQQIEELKH---QLEEETKAKNALAHALQSSR----HDCDLLREQYEE--EQEGKAELQ 1361

Query: 791  IESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEI 850
                   +E  +   + ++DA++      ++  E  +KL   LQE +EH++ +  K   +
Sbjct: 1362 RALSKANSEVAQWRTKYETDAIQRT----EELEEAKKKLAQRLQEAEEHVEAVNAKCASL 1417

Query: 851  EKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDK 910
            EK T+++L    +++++++  +ER N     L ++ +  +  L E ++ Y     +    
Sbjct: 1418 EK-TKQRL---QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEAS 1473

Query: 911  GELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKR-----QVD 965
             +    L T++ +VK  +E    +L+  R ++  LQ+   +    + +  K+     ++ 
Sbjct: 1474 QKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIK 1533

Query: 966  AIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 1021
              VE  + EI     E +  ++    K+ +I+ E+ ++  E  +     + +I QL
Sbjct: 1534 KQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQL 1589



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 124/552 (22%), Positives = 238/552 (43%), Gaps = 45/552 (8%)

Query: 497  QNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA 556
            + E+  +  E  K KD+        + LE   EKM    +++   Q+++  E +  A A 
Sbjct: 849  EKEMATMKEEFQKTKDELAKSEAKRKELE---EKMVTLLKEKNDLQLQVQSEADSLADAE 905

Query: 557  DREIYLLRTSLHRER------EQAQQLHQLLA-LKEQEHRKELETREFFTDADFQDALAK 609
            +R   L++  +  E       E+A++  ++ A L  ++ + E E  E   D D  +    
Sbjct: 906  ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 965

Query: 610  EIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELA 669
            ++ KE+   E  +K   E++  L +    L  E +       +   D++   E+    L 
Sbjct: 966  KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQ-AEEDKVNILT 1024

Query: 670  KSKHALIWAQRKENESSSLI--KDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEIL 727
            K+K  L   Q+ ++   SL   K L   ++  K KL    KL QE+  +++N        
Sbjct: 1025 KAKTKL--EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMEN-------- 1074

Query: 728  IEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQ---NR 784
              D +Q   ++E  + E   LIS++  ++++   L+ + K     + + G  +     +R
Sbjct: 1075 --DKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132

Query: 785  GKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQ 844
             K E Q   LSRE E + +  E    A   + ++   +    +KL+  L+E     + + 
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV 1192

Query: 845  EKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLN 904
              + +    +  +L E+   L  V +KLE+    K +LK +        E I KA   L 
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKE---KSELKMETDDLSSNAEAISKAKGNL- 1248

Query: 905  RKWHDKGELLCH-LETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMD--DAFK 961
                   E +C  LE QV E+K K E +++ +     +   LQ  A E    +D  DA  
Sbjct: 1249 -------EKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALV 1301

Query: 962  RQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMR--ELLEETCKNKKTMEAKIK 1019
             Q+    +A   +I +L ++ ++   + N   H ++      +LL E  + ++  +A+++
Sbjct: 1302 SQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1361

Query: 1020 Q-LAFALNEIQQ 1030
            + L+ A +E+ Q
Sbjct: 1362 RALSKANSEVAQ 1373



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 147/673 (21%), Positives = 277/673 (41%), Gaps = 99/673 (14%)

Query: 446  KLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKL-- 503
            +L + ID L +   + E   S   + TD L         +KG LE M   L++++ +L  
Sbjct: 1205 ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264

Query: 504  ------------TVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQ--QQAAQIRLIQEV 549
                        T +  + + +  ++ + L   +  + ++ R K+   QQ  +++   E 
Sbjct: 1265 KEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEE 1324

Query: 550  ELKASAA--------DREIYLLRTSLHREREQAQQLHQLLALKEQE---HRKELETREFF 598
            E KA  A          +  LLR     E+E   +L + L+    E    R + ET    
Sbjct: 1325 ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ 1384

Query: 599  TDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFR-------------I 645
               + ++A  K++A+  ++ E+ ++    K   L +    L+NE                
Sbjct: 1385 RTEELEEA-KKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACA 1443

Query: 646  ALTVEARRFQDV----KDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKT 701
            AL  + R F  V    K  +E    EL  S          + ES SL  +L  +    + 
Sbjct: 1444 ALDKKQRNFDKVLSEWKQKYEETQAELEAS----------QKESRSLSTELFKVKNVYEE 1493

Query: 702  KLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISEL-AAKESLIF 760
             L ++  L++E   NLQ +I+ L   I +  ++  ++E +K +  Q   E+ AA E    
Sbjct: 1494 SLDQLETLRRENK-NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552

Query: 761  GLRTER-KVWGH--ELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESD--------S 809
             L  E  K+     EL Q  S + +   + + +I+ L R +  + +T +S         +
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRN 1612

Query: 810  DALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVL 869
            DALR+K K+  D  E   +L    +   E ++  +     I K TQ  LD+     +++ 
Sbjct: 1613 DALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNT-QGILKETQLHLDDALRGQEDLK 1671

Query: 870  EKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQ---VKEVKE 926
            E+L     R   L+ +++     LE+  ++     ++  D  E +  L TQ   +   K+
Sbjct: 1672 EQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK 1731

Query: 927  KFENKEKKLKAERDKSIELQKNAMEKLHS-------MDDAFKRQVD--AIVEAHQAEIAQ 977
            K EN   +L++E ++ I+  +NA EK          M +  K++ D  A +E  +  + Q
Sbjct: 1732 KLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1791

Query: 978  LANEKQKCIDSA--------NLKVHQIEKEMREL----------LEETCKNKKTMEAKIK 1019
               + Q  +D A          ++ ++E  +REL            E  K  +  E ++K
Sbjct: 1792 TVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVK 1851

Query: 1020 QLAFALNEIQQDM 1032
            +L +   E ++++
Sbjct: 1852 ELTYQTEEDRKNV 1864



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 121/534 (22%), Positives = 210/534 (39%), Gaps = 106/534 (19%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANE 460
            +ES    TE+ KV       N Y+  ++QL+  R +    +Q  + L + I E  K  +E
Sbjct: 1475 KESRSLSTELFKVK------NVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHE 1528

Query: 461  KEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVEL---MKAKDQQEDH 517
             E I          ++  +     S    E  + ++Q E+ ++  E+   +  KD++ D 
Sbjct: 1529 LEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1588

Query: 518  LKH-----LRTLEKTLEKMERQKRQQQAAQIRL---IQEVELKASAADREIYLLRTSLHR 569
            LK      + T++ TL+   R +      + ++   + E+E++ + A+R   L   SL  
Sbjct: 1589 LKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANR---LAAESLRN 1645

Query: 570  ERE-----QAQQLHQLLALKEQEHRKE----LETREFFTDADFQD--ALAKEIAKEEKKH 618
             R      +  QLH   AL+ QE  KE    +E R     A+ ++  A  ++  +  K  
Sbjct: 1646 YRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIA 1705

Query: 619  EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWA 678
            EQ + +  E++ +L  Q   L N                K   EN  ++L      +I  
Sbjct: 1706 EQELLDASERVQLLHTQNTSLIN---------------TKKKLENDVSQLQSEVEEVIQE 1750

Query: 679  QRK-ENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQ 737
             R  E ++   I D   M +E K +        Q+T+A+L+     LE  ++D + +  +
Sbjct: 1751 SRNAEEKAKKAITDAAMMAEELKKE--------QDTSAHLERMKKNLEQTVKDLQHRLDE 1802

Query: 738  IELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRE 797
             E                                +LA +G    +   KLEA++  L  E
Sbjct: 1803 AE--------------------------------QLALKGGK--KQIQKLEARVRELEGE 1828

Query: 798  NECLRKTNESDSDALRI---KCKIIDDQTETIRK-------LKDCLQEKDEHIKRLQEKI 847
             E  +K N      LR    + K +  QTE  RK       L D LQ K +  KR  E+ 
Sbjct: 1829 VENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEE- 1887

Query: 848  TEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYS 901
                   +EQ +   S+  ++  +LE   ER +  + Q+    V+  E+    S
Sbjct: 1888 ------AEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKIS 1935



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 40/191 (20%), Positives = 80/191 (41%), Gaps = 4/191 (2%)

Query: 846  KITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGK---EVELEEIRKAYST 902
            K  E EK      +E     DE+ +   +  E +EK+   LK K   +++++    + + 
Sbjct: 844  KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903

Query: 903  LNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKR 962
               +     +    LE ++KEV E+ E +E+       K  +L+    E    +DD    
Sbjct: 904  AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963

Query: 963  QVDAIVEAHQAE-IAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 1021
                  E H  E   +   E+   +D    K+ + +K ++E  ++T  + +  E K+  L
Sbjct: 964  LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNIL 1023

Query: 1022 AFALNEIQQDM 1032
              A  +++Q +
Sbjct: 1024 TKAKTKLEQQV 1034


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  105 bits (261), Expect = 3e-22
 Identities = 160/806 (19%), Positives = 334/806 (41%), Gaps = 144/806 (17%)

Query: 340  RKECNRKVPRRSKI---PYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLAN 396
            R E  + V RR  I    Y+ +    +KH       ++    K+KP  LK       +AN
Sbjct: 802  RVEYQKMVERRESIFCIQYNVRAFMNVKHW-----PWMKLYFKIKP-LLKSAETEKEMAN 855

Query: 397  CPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHK 456
              M +E EK K E+ K +    E    + +V  + ++ + + + +   + L D  +   +
Sbjct: 856  --MKEEFEKTKEELAKTEAKRKE--LEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQ 911

Query: 457  HANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLT-----VELMKAK 511
                K  + +     T+R ++    E     +L     KL++E  +L      +EL  AK
Sbjct: 912  LIKTKIQLEAKIKEVTERAED----EEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967

Query: 512  DQQEDHL---------KHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA------ 556
             ++E H          + +  L++T+ K+ ++K+  Q A  + + +++ +          
Sbjct: 968  VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1027

Query: 557  ----DREIYLLRTSLHREREQAQQLHQLLA----------------------LKEQEHRK 590
                ++++  L  SL +E++    L +                         L E+  +K
Sbjct: 1028 KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK 1087

Query: 591  ELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDV-------LSQQYMDLENEF 643
            E E     +  + + AL  ++ K+ K+ +  I+E +E+I+          +Q  DL  E 
Sbjct: 1088 EFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147

Query: 644  RIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQK--- 700
                  E     +   G  +   E+ K + A     R++ E ++L  + T     +K   
Sbjct: 1148 E-----EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1202

Query: 701  --TKLAEVSKLKQETAANLQNQINTLEILIED--------DKQKS-------------IQ 737
               +L E     Q     L+ + + +++ I+D         K K               +
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSE 1262

Query: 738  IELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQ-NRGK--LEAQIESL 794
            I+  + E+ +LI++L A+ +    L+TE   +  +L ++ + ++Q +RGK     QIE L
Sbjct: 1263 IKTKEEEQQRLINDLTAQRAR---LQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEEL 1319

Query: 795  SRENECLRKTNESDSDAL---RIKCKIIDDQTETIRKLKDCLQ----EKDEHIKRLQEKI 847
             R+ E   K   + + AL   R  C ++ +Q E  ++ K  LQ    + +  + + + K 
Sbjct: 1320 KRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKY 1379

Query: 848  TEIEKCTQEQLDEKSSQLDEVLEKLERHNE-----------RKEKLKQQLKGKEVELEEI 896
                    E+L+E   +L + L+  E H E            K++L+ +++   +++E  
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERT 1439

Query: 897  RKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSM 956
              A + L++K  +  ++L   + + +E   + E  +K+ ++   +  ++ KNA E+    
Sbjct: 1440 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKI-KNAYEESLDQ 1498

Query: 957  DDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEK----------EMRELLEE 1006
             +  KR+   +    Q EI+ L  +    I     ++H++EK          E++  LEE
Sbjct: 1499 LETLKRENKNL----QQEISDLTEQ----IAEGGKRIHELEKIKKQVEQEKSELQAALEE 1550

Query: 1007 TCKNKKTMEAKIKQLAFALNEIQQDM 1032
               + +  E KI ++   LN+++ ++
Sbjct: 1551 AEASLEHEEGKILRIQLELNQVKSEV 1576



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 148/675 (21%), Positives = 291/675 (43%), Gaps = 84/675 (12%)

Query: 426  LVEQLDQEREKRWRAEQAENKLMDYIDELHKH----ANEKEDIHSLALLTTDRLKEIIFR 481
            L EQ+D  +  + + E+ ++++   ID+L  +    +  K ++  +     D+L EI  +
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTK 1266

Query: 482  ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQ--QQ 539
            E              Q  I  LT +  + + +  ++ + L   +  + ++ R K+   QQ
Sbjct: 1267 EEEQ-----------QRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315

Query: 540  AAQIRLIQEVELKASAA--------DREIYLLRTSLHREREQAQQLHQLLALKEQE---H 588
              +++   E E+KA +A          +  LLR     E+E   +L + ++    E    
Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQW 1375

Query: 589  RKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFR---- 644
            R + ET       + ++A  K++A+  +  E+ ++    K   L +    L+NE      
Sbjct: 1376 RTKYETDAIQRTEELEEA-KKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMI 1434

Query: 645  -IALTVEARRFQDVKD-GFENVATEL---AKSKHALIWAQRKENESSSLIKDLTCMVKEQ 699
             +  T  A    D K   F+ +  E     +  HA + A +KE  S SL  +L  +    
Sbjct: 1435 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE--SRSLSTELFKIKNAY 1492

Query: 700  KTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISEL-AAKESL 758
            +  L ++  LK+E   NLQ +I+ L   I +  ++  ++E +K +  Q  SEL AA E  
Sbjct: 1493 EESLDQLETLKRENK-NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEA 1551

Query: 759  IFGLRTER-KVWGH--ELAQQGSSLAQNRGKLEAQIESLSREN----ECLRKTNESD--- 808
               L  E  K+     EL Q  S + +   + + +I+ + R +    E ++ T +++   
Sbjct: 1552 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRS 1611

Query: 809  -SDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDE 867
             +DA+R+K K+  D  E   +L    +   E ++  +     I K TQ  LD+     ++
Sbjct: 1612 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNT-QAILKDTQLHLDDALRSQED 1670

Query: 868  VLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQ---VKEV 924
            + E+L     R   L+ +++     LE+  ++     ++  D  E +  L TQ   +   
Sbjct: 1671 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1730

Query: 925  KEKFENKEKKLKAERDKSIELQKNAMEKLHS-------MDDAFKRQVD--AIVEAHQAEI 975
            K+K E    +++ E +  I+  +NA EK          M +  K++ D  A +E  +  +
Sbjct: 1731 KKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790

Query: 976  AQLANEKQKCIDSA--------NLKVHQIEKEMRELLEET-CKNKKTMEA---------K 1017
             Q   + Q  +D A          ++ ++E  +REL  E   + K+ +EA         K
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERK 1850

Query: 1018 IKQLAFALNEIQQDM 1032
            +K+L +   E ++++
Sbjct: 1851 VKELTYQTEEDRKNI 1865



 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 135/643 (20%), Positives = 266/643 (41%), Gaps = 118/643 (18%)

Query: 389  YVSSSLANCPMLQESEKPKTEIIKVDQSHSE---------DNTYQSL---VEQLDQEREK 436
            Y + ++     L+E++K   + ++  + H E         + T Q L   VE L  + E+
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVER 1438

Query: 437  RWRAEQAENKLMDYIDELHKHANEK-EDIHSLALLTTDRLKEI---IFRERNSKGQLEVM 492
               A  A +K     D++     +K E+ H+    +    + +   +F+ +N+  +    
Sbjct: 1439 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ 1498

Query: 493  VHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELK 552
            +  L+ E K L  E+    +Q  +  K +  LEK  +++E++K + QAA    ++E E  
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA----LEEAE-- 1552

Query: 553  ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIA 612
            AS    E  +LR  L           +L  +K +  RK  E  E             EI 
Sbjct: 1553 ASLEHEEGKILRIQL-----------ELNQVKSEVDRKIAEKDE-------------EID 1588

Query: 613  KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK 672
            + ++ H ++++  Q  +D   +   D       A+ ++ +   D+ +    +  +L  + 
Sbjct: 1589 QMKRNHIRIVESMQSTLDAEIRSRND-------AIRLKKKMEGDLNE----MEIQLNHAN 1637

Query: 673  HALIWAQRKENESSSLIKDLTCMVKE---QKTKLAEVSKLKQETAANLQNQINTLEILIE 729
                 A R    + +++KD    + +    +  L E   + +  A  LQ +I  L   +E
Sbjct: 1638 RMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE 1697

Query: 730  --DDKQKSIQIELL-KHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGK 786
              +  +K  + ELL   E+VQL                        L  Q +SL   + K
Sbjct: 1698 QTERSRKIAEQELLDASERVQL------------------------LHTQNTSLINTKKK 1733

Query: 787  LEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEK 846
            LE  I  +  E E + +   +  +  +   K I D      +LK   Q+   H++R+++ 
Sbjct: 1734 LETDISQIQGEMEDIIQEARNAEEKAK---KAITDAAMMAEELKK-EQDTSAHLERMKKN 1789

Query: 847  ITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 906
            + +  K  Q +LDE + QL   L+  ++  ++ E   ++L+G EVE E+ R   +    +
Sbjct: 1790 LEQTVKDLQHRLDE-AEQL--ALKGGKKQIQKLEARVRELEG-EVESEQKRNVEAVKGLR 1845

Query: 907  WHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDA 966
             H         E +VKE+  + E   K +       + LQ + ++KL +   ++KRQ + 
Sbjct: 1846 KH---------ERKVKELTYQTEEDRKNI-------LRLQ-DLVDKLQAKVKSYKRQAEE 1888

Query: 967  IVEAHQAEIAQL------ANEKQKCIDSANLKVHQIEKEMREL 1003
              E     +++         E ++  D A  +V+++  + RE+
Sbjct: 1889 AEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  103 bits (258), Expect = 6e-22
 Identities = 143/688 (20%), Positives = 286/688 (41%), Gaps = 94/688 (13%)

Query: 408  TEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSL 467
            T++  + Q   ++    +  E+L + REK+  AE    ++     +L     + ++    
Sbjct: 832  TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA 891

Query: 468  ALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHL----RT 523
                    +E+  R    K +LE + H L+  +           +++E+  +HL    + 
Sbjct: 892  ETELCAEAEELRARLTAKKQELEEICHDLEARV-----------EEEEERCQHLQAEKKK 940

Query: 524  LEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLAL 583
            +++ ++++E Q  ++++A+    Q+++L+    + ++  L      E EQ     Q   L
Sbjct: 941  MQQNIQELEEQLEEEESAR----QKLQLEKVTTEAKLKKL------EEEQIILEDQNCKL 990

Query: 584  KEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKI-------------- 629
             +++   E    EF T+   ++  +K +AK + KHE MI + +E++              
Sbjct: 991  AKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR 1050

Query: 630  -------DVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKE 682
                     LS Q  +L+ +        A++ ++++     V  E A+   AL   +  E
Sbjct: 1051 RKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE 1110

Query: 683  NESSSLIKDLTC------MVKEQKTKLAE--------------VSKLKQETAANLQNQIN 722
            ++ S L +DL          ++QK  L E               +  +QE  +  + ++N
Sbjct: 1111 SQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVN 1170

Query: 723  TLEILIEDD-KQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLA 781
             L+  +E++ K    QI+ ++ +  Q + ELA +       +T+R     E A+Q  +L 
Sbjct: 1171 ILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE-----QTKRVKANLEKAKQ--TLE 1223

Query: 782  QNRGKLEAQIESLSR---ENECLRKTNESDSDALRIKCKIIDD-QTETIRKLKDCLQEKD 837
              RG+L  +++ L +   ++E  RK  E+    L++K    +  +TE   K+     E D
Sbjct: 1224 NERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283

Query: 838  EHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIR 897
                 L +  ++  K T++      SQL +  E L+  N +K  L  +LK  E E    R
Sbjct: 1284 NVTGLLSQSDSKSSKLTKD-FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR 1342

Query: 898  KAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKN--------- 948
            +         H+  + +  L  QV ++K+K E+    L+   +   +LQK+         
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402

Query: 949  ----AMEKLHSMDDAFKRQVDAIVE--AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRE 1002
                A +KL       ++++D ++    HQ + A    +KQK  D    +   I  +  E
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462

Query: 1003 LLEETCKNKKTMEAKIKQLAFALNEIQQ 1030
              +      +  E K   LA AL E  +
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAME 1490



 Score =  102 bits (253), Expect = 2e-21
 Identities = 174/839 (20%), Positives = 356/839 (42%), Gaps = 142/839 (16%)

Query: 294  EIKLQKLDDQILQLLNETSN---SIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 350
            E KL+KL+++  Q++ E  N   + +  L +D   +  T++T E +    K   +   + 
Sbjct: 970  EAKLKKLEEE--QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE--KSKSLAKLKNKH 1025

Query: 351  SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMK------PPYLKELYVSSSLANCPMLQESE 404
              +  D +  + ++   K         RK++         + EL    +     + ++ E
Sbjct: 1026 EAMITDLE--ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083

Query: 405  KPKTEIIKVDQSHSEDNT-----------YQSLVEQLDQEREKRWRAEQAENKLMDYIDE 453
            + +  + +V++  ++ N               L E L+ ER  R +AE+ +    D  +E
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR---DLGEE 1140

Query: 454  LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHK--LQNEIKKLTVELMKAK 511
            L     E ED     L +T   +E+      SK + EV + K  L+ E K    ++    
Sbjct: 1141 LEALKTELED----TLDSTAAQQEL-----RSKREQEVNILKKTLEEEAKTHEAQI---- 1187

Query: 512  DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRT----SL 567
              QE   KH + +E+  E++E+ KR +   + +  Q +E +      E+ +L      S 
Sbjct: 1188 --QEMRQKHSQAVEELAEQLEQTKRVKANLE-KAKQTLENERGELANEVKVLLQGKGDSE 1244

Query: 568  HREREQAQQLHQLLALKEQEHRKELETREFFTDADFQ-DALAKEIAKEEKKHEQMIKEYQ 626
            H+ ++   QL +L     +  R   E  +  T    + D +   +++ + K  ++ K++ 
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304

Query: 627  EKIDVL--SQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKH------ALIWA 678
                 L  +Q+ +  EN  +++L+ + ++ +D K+ F     E  ++KH      A + A
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364

Query: 679  Q----RKENESS------------SLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQIN 722
            Q    +K+ E S             L KDL  + +  + K+A   KL ++T   LQ +++
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL-EKTKTRLQQELD 1423

Query: 723  TLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQ 782
             L + ++  +Q +  +E    +K +   +L A+E  I     E +      A++  + A 
Sbjct: 1424 DLLVDLDHQRQSACNLE----KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKAL 1479

Query: 783  NRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKR 842
            +  +   +      E E L K   ++ + L      +      + K K  L+++ E +K 
Sbjct: 1480 SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT 1539

Query: 843  LQEKITEIEKCTQE-------QLDEKSSQLDEVLE-KLERHNERKEKLKQQLKGKEVELE 894
              E++ +  + T++        L    +Q +  L+ + E+  E+K++L +Q++  E ELE
Sbjct: 1540 QLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE 1599

Query: 895  EIRKAYS---------------------TLNRKWHDKGELLCHLETQVK----------- 922
            + RK  S                     + N+   +  + L  L+ Q+K           
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659

Query: 923  ---EVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQ-- 977
               E+  + +  EKKLK+   + I+LQ    E+L + + A KRQ     +    EIA   
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMIQLQ----EELAAAERA-KRQAQQERDELADEIANSS 1714

Query: 978  ----LANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 1032
                LA E+++ +++   ++ Q+E+E    LEE   N + +  ++K+    +++I  D+
Sbjct: 1715 GKGALALEEKRRLEA---RIAQLEEE----LEEEQGNTELINDRLKKANLQIDQINTDL 1766



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 120/563 (21%), Positives = 249/563 (44%), Gaps = 48/563 (8%)

Query: 491  VMVHKLQNEIKKLTVELMKAKDQQ---EDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQ 547
            + V + + E+     EL+K +++Q   E+ L  + TL+  L   + Q ++Q  A+  L  
Sbjct: 838  LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897

Query: 548  EVE---LKASAADREI----YLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTD 600
            E E    + +A  +E+    + L   +  E E+ Q L Q    K Q++ +ELE +     
Sbjct: 898  EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL-QAEKKKMQQNIQELEEQ----- 951

Query: 601  ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG 660
             + +++  +++  E+   E  +K+ +E+  +L  Q   L  E ++           ++D 
Sbjct: 952  LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL-----------LEDR 1000

Query: 661  FENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AANL 717
                 T L + +       + +N+  ++I DL   ++ ++ +  E+ K +++    + +L
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060

Query: 718  QNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQG 777
             +QI  L+  I + K +  + E      +  + E AA++++      E +    EL +  
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120

Query: 778  SSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKD 837
             S   +R K E Q   L  E E L+   E   D+   + ++   + + +  LK       
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK------- 1173

Query: 838  EHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIR 897
               K L+E+    E   QE   + S  ++E+ E+LE+    K  L++  +  E E  E+ 
Sbjct: 1174 ---KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA 1230

Query: 898  KAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDK--SIELQKNAMEKLHS 955
                 L +   D       +E Q++E++ KF   E+      DK   ++++ + +  L S
Sbjct: 1231 NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290

Query: 956  MDDAFKRQVD---AIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKE---MRELLEETCK 1009
              D+   ++    + +E+   +  +L  E+ +   S + K+ Q+E E    RE LEE  +
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE 1350

Query: 1010 NKKTMEAKIKQLAFALNEIQQDM 1032
             K  +E +I  L   + ++++ M
Sbjct: 1351 AKHNLEKQIATLHAQVADMKKKM 1373



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 154/706 (21%), Positives = 302/706 (42%), Gaps = 105/706 (14%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQER----EKRWRAEQAENKLMDYIDELHK 456
            +ES + K ++ KV        T ++ +++L++E+    ++  +  + +  L D I E   
Sbjct: 955  EESARQKLQLEKV--------TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006

Query: 457  HANEKED-IHSLALLTTDR------LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMK 509
            +  E+E+   SLA L          L+E + RE   + +LE    KL+ +   L+ ++ +
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066

Query: 510  AKDQQEDHLKHLRTLEKTLE----KMERQKRQQQAAQIRLIQEVELKASAADREIYLLRT 565
             + Q  +    L   E+ L+    ++E +  Q+  A ++ I+E+E + S    ++   R 
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA-LKKIRELESQISELQEDLESERA 1125

Query: 566  SLHREREQAQQLHQLLALKEQEHRKELET----REFFTDADFQ-DALAKEIAKEEKKHEQ 620
            S ++  +Q + L + L   + E    L++    +E  +  + + + L K + +E K HE 
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185

Query: 621  MIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWA-- 678
             I+E ++K    SQ   +L  +      V+A   +  K   EN   ELA     L+    
Sbjct: 1186 QIQEMRQKH---SQAVEELAEQLEQTKRVKAN-LEKAKQTLENERGELANEVKVLLQGKG 1241

Query: 679  ----------------QRKENESSSLIKDLTCMVKEQKTKLAEV-----------SKLKQ 711
                            Q K NE   +  +L   V + + +L  V           SKL +
Sbjct: 1242 DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK 1301

Query: 712  ETAANLQNQI-NTLEILIEDDKQK---SIQIELLKHEKVQLISELAAKESLIFGLRTERK 767
            + +A L++Q+ +T E+L E+++QK   S +++ ++ EK     +L  +E     L  +  
Sbjct: 1302 DFSA-LESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIA 1360

Query: 768  VWGHELAQQGSSLAQNRG----------KLEAQIESLSRENE-------CLRKTNESDSD 810
                ++A     +  + G          KL+  +E LS+ +E        L KT      
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420

Query: 811  ALRIKCKIIDDQTETIRKLKDCLQEKDEHI---KRLQEKITEIEKCTQEQLDEKSSQLDE 867
             L      +D Q ++   L+   ++ D+ +   K +  K  E     + +  EK ++   
Sbjct: 1421 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480

Query: 868  VLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEK 927
            +   LE   E+K +L++  K    E+E++  +   + +  H+  +    LE QV+E+K +
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540

Query: 928  FENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANE------ 981
             E  E +L+A  D  + L+ N    L +M   F+R +    E  + +  QL  +      
Sbjct: 1541 LEELEDELQATEDAKLRLEVN----LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEA 1596

Query: 982  ------KQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 1021
                  KQ+ +  A  K  ++E ++++L        K  +  IKQL
Sbjct: 1597 ELEDERKQRSMAVAARK--KLEMDLKDLEAHIDSANKNRDEAIKQL 1640



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 132/618 (21%), Positives = 248/618 (40%), Gaps = 102/618 (16%)

Query: 399  MLQESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKH 457
            +LQE  + K  +  K+ Q   E N+++   EQL++E E +   E+    L   + ++ K 
Sbjct: 1316 LLQEENRQKLSLSTKLKQVEDEKNSFR---EQLEEEEEAKHNLEKQIATLHAQVADMKKK 1372

Query: 458  ANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDH 517
              +        L T + +K  + ++     Q         ++++K    L +  D     
Sbjct: 1373 MEDSVG----CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD 1428

Query: 518  LKHLR----TLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 573
            L H R     LEK  +K ++   +++    +  +E + +A A  RE      SL R  E+
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD-RAEAEAREKETKALSLARALEE 1487

Query: 574  AQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLS 633
            A +    L    ++ R E+E  +  +  D       E+ K ++  EQ ++E + +++ L 
Sbjct: 1488 AMEQKAELERLNKQFRTEME--DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELE 1545

Query: 634  QQYMDLEN-EFRIALTVEARRFQDVKD--GFENVATELAKS-----------------KH 673
             +    E+ + R+ + ++A + Q  +D  G +  + E  K                  + 
Sbjct: 1546 DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605

Query: 674  ALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTL-------EI 726
            ++  A RK+ E    +KDL   +        E  K  ++  A +++ +  L       E 
Sbjct: 1606 SMAVAARKKLEMD--LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE 1663

Query: 727  LIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQ---QGSSLAQN 783
            ++   K+   +++ ++ E +QL  ELAA E      + ER     E+A    +G+   + 
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723

Query: 784  RGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI--- 840
            + +LEA+I  L  E E  +   E  +D L+ K  +  DQ  T   L+    +K+E+    
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELINDRLK-KANLQIDQINTDLNLERSHAQKNENARQQ 1782

Query: 841  -----KRLQEKITEIE-------KCTQEQLDEKSSQLDEVLE----------KLERHNER 878
                 K L+ K+ E+E       K +   L+ K +QL+E L+          K  R  E+
Sbjct: 1783 LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842

Query: 879  KEK-----------------------------LKQQLKGKEVELEEIRKAYSTLNRKWHD 909
            K K                             LK+QL+  E E +    +   L R+  D
Sbjct: 1843 KLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED 1902

Query: 910  KGELLCHLETQVKEVKEK 927
              E    +  +V  +K K
Sbjct: 1903 ATETADAMNREVSSLKNK 1920



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 69/355 (19%), Positives = 147/355 (41%), Gaps = 35/355 (9%)

Query: 291  LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 350
            L+ E+ LQ +  Q  + L       +   ++  R  R+ +   E +   RK+ +  V  R
Sbjct: 1556 LRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE---RKQRSMAVAAR 1612

Query: 351  SKIPYDAKTIQT-IKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPM-LQESEKPKT 408
             K+  D K ++  I   NKN +  +   RK++          + + +C   L ++   + 
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ----------AQMKDCMRELDDTRASRE 1662

Query: 409  EIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLA 468
            EI+   Q+   +   +S+  ++ Q +E+   AE+A+ +     DEL           +LA
Sbjct: 1663 EILA--QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720

Query: 469  LLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTL 528
            L    RL+  I +      + +     + + +KK  +++ +          H +  E   
Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780

Query: 529  EKMERQKRQQQAAQIRLIQEVE------LKAS--AADREIYLLRTSLHREREQAQQLHQL 580
            +++ERQ ++ +      +QE+E       KAS  A + +I  L   L  E ++ Q     
Sbjct: 1781 QQLERQNKELKVK----LQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQ----- 1831

Query: 581  LALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQ 635
             A  +Q  R E + ++     D +   A++   +  K    +K+ + +++   ++
Sbjct: 1832 -AACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEE 1885


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score =  103 bits (257), Expect = 8e-22
 Identities = 135/684 (19%), Positives = 284/684 (41%), Gaps = 95/684 (13%)

Query: 400  LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHAN 459
            LQ+  + + ++ ++ Q  S   T +  V +L +E  +R  AE               H  
Sbjct: 232  LQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE---------------HER 276

Query: 460  EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 519
            + +++     L    L+E+  R    K  L      ++  ++ L  + + AK  +EDH +
Sbjct: 277  QAKEL----FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332

Query: 520  ---------HLRTLEKTLEKMERQ---------KRQQQAAQIRLIQEVELKASAADREIY 561
                     H+  LE  LE+ E++         +R + A      + ++      D +I 
Sbjct: 333  TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392

Query: 562  LLRTSLHREREQAQQLHQLLALKEQEHRKELETREFF-TDADFQDALAKEIAKEEKKHEQ 620
             +   L    E+ Q L    AL  +E  +E++  E + + + F      ++ +E  + + 
Sbjct: 393  SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452

Query: 621  MIKEYQEKIDVLSQQYMDLENEFRI---ALTVEARRFQDVKDGFENVATELAKSKHALIW 677
             +   Q K++ L+ Q+ D +    +   +LT + +R   ++   + +   L         
Sbjct: 453  ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRL--------- 503

Query: 678  AQRKENESSSLIKDLTCMVKEQKTKLAEVSKLK-------------QETAANLQNQINTL 724
             + KE   +   K +  M +E+ T+  E+  LK             Q+   NLQ Q+   
Sbjct: 504  -EEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK 562

Query: 725  EILIEDDKQ--KSIQIELLKHEKVQLISE--LAAKESLIFGLRTERKVWGHELAQQGSSL 780
            E  +   K+  KS+Q +    +      E  LA KE  I  L+ +R     E  ++  + 
Sbjct: 563  EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNY 622

Query: 781  AQNRGKLEAQIE----SLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEK 836
             ++   L+ ++      LS +   L    E  S       K    +   ++ L+  L++K
Sbjct: 623  KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK----KDSRLKTLEIALEQK 678

Query: 837  DEHIKRLQEKITEIEKCTQEQLDEKSS-QLDEVLEKLERHNERKEKLKQQLKGKEVELEE 895
             E   +++   ++++K  +  L+ ++S ++ + ++ LER   R    K +    + E++ 
Sbjct: 679  KEECLKME---SQLKKAHEAALEARASPEMSDRIQHLEREITR---YKDESSKAQAEVDR 732

Query: 896  IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIEL-------QKN 948
            + +    +  + +DK + +  LE QVK+  +K  N + K + E+ KS ++       + N
Sbjct: 733  LLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN 792

Query: 949  AMEKLHSMDDAFKRQVDAIVEAHQA--EIAQLANEKQKCIDSANLKVHQIEKEMRELL-- 1004
              +    + D+ +++ D I E  +A  E  Q+  E++  +          EK++ ELL  
Sbjct: 793  LNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMA 852

Query: 1005 -EETCKNKKTMEAKIKQLAFALNE 1027
             E+  +  ++M+AK+     +L E
Sbjct: 853  MEKVKQELESMKAKLSSTQQSLAE 876



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 115/571 (20%), Positives = 238/571 (41%), Gaps = 68/571 (11%)

Query: 428 EQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKG 487
           E++ Q    R  ++  +NK+     EL      ++D   LAL T  +L+ +  +  +SK 
Sbjct: 421 EEMKQMEVYRSHSKFMKNKIGQVKQEL-----SRKDTELLALQT--KLETLTNQFSDSKQ 473

Query: 488 QLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQ 547
            +EV+   L  + ++  + L    D     L+   T+     K  +   +++  Q   I 
Sbjct: 474 HIEVLKESLTAKEQRAAI-LQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 532

Query: 548 EVELKASAADREIYLLRTSLHREREQAQQLH-QLLALKEQEHRKELETREFFTD-ADFQD 605
           +++      +R++ +L+  +   +EQ +    Q+ +LKE+    + +T    T     ++
Sbjct: 533 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 592

Query: 606 ALAKEIAKEEKKHEQMIK---EYQEKIDVLSQQYMDLENEFRIA---LTVEARRFQDVKD 659
           ALA++    E+  EQ  +   E QE+ID   +   DL+ +  +    L+ +     D+K+
Sbjct: 593 ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 652

Query: 660 GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQN 719
              ++A+   K    L     K  E +   K   C+  E + K A  + L+   +  + +
Sbjct: 653 HASSLASSGLKKDSRL-----KTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSD 707

Query: 720 QINTLEILIEDDKQKSIQIELLKHEKVQLISELAA----KESLIFGLRTERKVWGHELAQ 775
           +I  LE  I   K +S + +      ++++ E+      K+  I  L  + K    ++A 
Sbjct: 708 RIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVAN 767

Query: 776 QGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQE 835
                   + K    +E   R  + L  +++   D+LR K   I++  E +R+      E
Sbjct: 768 LKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE 827

Query: 836 KDEHI-----------KRLQEKITEIEKC-------------TQEQLDEKSSQLDEVLEK 871
           ++  +           K+++E +  +EK              TQ+ L EK + L  +  +
Sbjct: 828 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 887

Query: 872 LERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENK 931
             +H E   ++KQ         E +  A S       +K   +  LE  +   K+K + +
Sbjct: 888 RRKHLEEVLEMKQ---------EALLAAIS-------EKDANIALLE--LSSSKKKTQEE 929

Query: 932 EKKLKAERDKSI-ELQKNAMEKLHSMDDAFK 961
              LK E+D+ + +L++    ++  M D ++
Sbjct: 930 VAALKREKDRLVQQLKQQTQNRMKLMADNYE 960



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 44/304 (14%)

Query: 294 EIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKR-------DTDITSESDYGNRKECNRK 346
           EI L++  ++ L++ ++   + +  LE    P+        + +IT   D  ++ +   +
Sbjct: 672 EIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQA--E 729

Query: 347 VPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKP 406
           V R  +I    K ++  K  N          R++K    K       +AN    ++ EK 
Sbjct: 730 VDRLLEI---LKEVENEK--NDKDKKIAELERQVKDQNKK-------VANLKHKEQVEKK 777

Query: 407 KTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHS 466
           K+  +  +    EDN   S  +  D  R+K  R E+ E  L + +               
Sbjct: 778 KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ-------------- 823

Query: 467 LALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEK 526
              +T +R + ++ +E +++   E  V +L   ++K+  EL   K +     + L   E 
Sbjct: 824 ---ITAER-EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET 879

Query: 527 TLEKMERQKRQQQAAQIRLIQEVELKA-SAADREIYLLRTSLHREREQAQQLHQLLALKE 585
            L  +  ++R+     + + QE  L A S  D  I LL  S  +++ Q     ++ ALK 
Sbjct: 880 HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQ----EEVAALKR 935

Query: 586 QEHR 589
           ++ R
Sbjct: 936 EKDR 939



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 63/295 (21%), Positives = 116/295 (39%), Gaps = 65/295 (22%)

Query: 787  LEAQIESLSRENECLRKTNESD---------------SDALRIKCKIIDDQTETIRKLKD 831
            L+ Q++ + REN+ LRK  E                 S  L+ +  +  D+   I   K+
Sbjct: 154  LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213

Query: 832  ---CLQEKDEHIK----------RLQEKITEI----------EKCTQEQLDEKSSQLDEV 868
                +QE+++H++          R+Q  + ++          E C  E  +E   +L   
Sbjct: 214  QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273

Query: 869  LEK-----------LERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKW---------H 908
             E+           LE    R E  KQ L  ++   E I+K    L  K          H
Sbjct: 274  HERQAKELFLLRKTLEEMELRIETQKQTLNARD---ESIKKLLEMLQSKGLSAKATEEDH 330

Query: 909  DKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAME--KLHSMDDAFKRQVDA 966
            ++   L   E  V  ++   E KEK+    R++     +NA +  K  ++    + + D+
Sbjct: 331  ERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK-DS 389

Query: 967  IVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 1021
             + + +  +  L  E Q    +  L   + E+EM++ +E    + K M+ KI Q+
Sbjct: 390  KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ-MEVYRSHSKFMKNKIGQV 443


>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
          Length = 1213

 Score =  103 bits (257), Expect = 8e-22
 Identities = 140/660 (21%), Positives = 285/660 (43%), Gaps = 93/660 (14%)

Query: 404  EKPKTEIIKVDQSHSEDNTYQSLVEQLD-QEREKRWRAEQAENKLMDYIDELHKHA---N 459
            EKP +E+ ++++   E  TY+ ++EQL   E+  R    + EN       E HKH    N
Sbjct: 145  EKPISELDRLEEKQKE--TYRRMLEQLLLAEKCHRRTVYELEN-------EKHKHTDYMN 195

Query: 460  EKEDIHSLALLTTDRLKEIIFRERNSKGQLEV----MVHKLQNEIKKLTVELMKAKDQQE 515
            + +D  +L     +RLK+++ +E+  + + E      ++KL++E+ KL    +   D+++
Sbjct: 196  KSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQ 255

Query: 516  DHLKHL--------------RTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIY 561
             H++ L              R  E+ L+ +  + ++ +   ++L  + E KAS   +E  
Sbjct: 256  MHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHE 315

Query: 562  LLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQ-DALAKEIAKEEKKHEQ 620
             +   L  +    +QL   L    Q   +  ET +    A+ +   L  +IAK E  +  
Sbjct: 316  EMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSS 375

Query: 621  MIKEYQ-------------EKIDVLSQQYMDL------ENEFRIALTVEARRFQDVKDGF 661
            ++ E +             E+I     Q  +L      E      L +E  + Q      
Sbjct: 376  LMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSEL 435

Query: 662  ENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQI 721
            E +    +KSK           +  +L KDL   ++  K+++ E+           ++++
Sbjct: 436  EKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS--------ESRL 487

Query: 722  NTLEILIEDD--KQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWG-------HE 772
               E+ ++DD  K KS  + +L  E+  ++ ++  +E  + GL    KV          +
Sbjct: 488  EKAELSLKDDLTKLKSFTV-MLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEK 546

Query: 773  LAQQGSSLAQNRGKLEAQIESLSRE-NECLRKTNESDSDALRIKCKIIDDQTETIRKLKD 831
            L ++   L + + ++E ++ +L+RE +E + K    +  +  + C +     + ++K  D
Sbjct: 547  LIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSV-----DLLKKRLD 601

Query: 832  CLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEV 891
             ++E +  I R + +      C +          D  +++L    ER +K  QQL+  E 
Sbjct: 602  GIEEVEREITRGRSRKGSELTCPE----------DNKIKELTLEIERLKKRLQQLEVVEG 651

Query: 892  ELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAME 951
            +L +    Y  L +K+  + +    L  Q++E+K +      K KA     +  Q+  + 
Sbjct: 652  DLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQI----AKNKAIEKGEVVSQEAELR 707

Query: 952  KLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNK 1011
                +++A  R + A V+A + +I +L N++ +    + L+V     + R  +EE  KNK
Sbjct: 708  HRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQL---SQLQVDYSVLQQR-FMEEENKNK 763



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 79/349 (22%), Positives = 146/349 (41%), Gaps = 75/349 (21%)

Query: 399 MLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHA 458
           +++ES+K    ++K+ +S  E+  Y +L  + D+   K    E+  ++L   +D L K  
Sbjct: 547 LIEESKK----LLKL-KSEMEEKVY-NLTRERDELIGKLKSEEEKSSELSCSVDLLKKRL 600

Query: 459 NEKEDIHSLALLTTDRL-KEIIFRERNSKGQLEVMVHKLQNEIKKLTV---ELMKAKDQQ 514
           +  E++         R   E+   E N   +L + + +L+  +++L V   +LMK +D+ 
Sbjct: 601 DGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEY 660

Query: 515 EDHLKHLRT-------LEKTLEKMERQKRQQQAAQIRLI--QEVELK-------ASAAD- 557
           +   +  RT       L + LE+++ Q  + +A +   +  QE EL+       A + D 
Sbjct: 661 DQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL 720

Query: 558 -REIYLLRTSLHREREQAQQLHQLLA--------LKEQEHR------------KELETRE 596
             E+  L+  +H    +  QL QL            E+E++            KELE  +
Sbjct: 721 KAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSK 780

Query: 597 FF------------------TDADFQ-DALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYM 637
            +                  T    Q DA++ E A+EE     + K +QE+  ++S    
Sbjct: 781 RYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMS---- 836

Query: 638 DLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESS 686
              N  ++ L     R   V D +   A EL   K  + W +++EN  S
Sbjct: 837 ---NLRQVGLKKPVER-SSVLDRYPPAANELTMRKSWIPWMRKRENGPS 881



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 72/363 (19%), Positives = 158/363 (43%), Gaps = 42/363 (11%)

Query: 690  KDLTCMVKEQKTKL----AEVSKLKQETAANL--QNQINTLEILIEDDKQKSIQIELLKH 743
            +D+  M+K +KTK     A     + E    +  ++ I   E  I +D  +    EL + 
Sbjct: 95   EDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRL 154

Query: 744  EKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRK 803
            E+ Q  +     E L+   +  R+   +EL  +         K +     L +E E L+K
Sbjct: 155  EEKQKETYRRMLEQLLLAEKCHRRTV-YELENEKHKHTDYMNKSDDFTNLLEQERERLKK 213

Query: 804  TNESDSDALRIKCKIIDDQTETIRKLKDCL-----------QEKDEHIKRLQEKITEIEK 852
              E +      K K   +  + + KL+D L            E+  HI++L  +  +++ 
Sbjct: 214  LLEQEKAYQARKEK---ENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQD 270

Query: 853  CTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGE 912
             TQ+  +E+        EKL+    + ++ +Q+L   EV+ E     +S  + + + K  
Sbjct: 271  LTQKLREEE--------EKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAK-- 320

Query: 913  LLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQ 972
             L + E+  ++++ K     ++++   + +  LQK A E+L  + D   +        + 
Sbjct: 321  -LANQESHNRQLRLKLVGLTQRIEELEETNKNLQK-AEEELQELRDKIAKGECG----NS 374

Query: 973  AEIAQLANEKQKCI-----DSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNE 1027
            + +A++ N +++ +     D    K     +E+R+ L+E   + K +  ++++L   ++E
Sbjct: 375  SLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSE 434

Query: 1028 IQQ 1030
            +++
Sbjct: 435  LEK 437


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score =  102 bits (255), Expect = 1e-21
 Identities = 130/680 (19%), Positives = 299/680 (43%), Gaps = 50/680 (7%)

Query: 277 CQSSEPEK---NNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITS 333
           C S E EK   + H+  L+ EI+ Q   D  +++L      ++  L       R  +   
Sbjct: 66  CHSPEDEKKASHQHQEALRREIEAQ---DHTIRILTCQKTELETALYYSQDAARKFE--- 119

Query: 334 ESDYGNRKECNRKVPRRSKIPYDA-KTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSS 392
           + + G  K+   ++        +  + +  +   +K  + ++    K +     ELY  +
Sbjct: 120 DGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELY-RN 178

Query: 393 SLANCPMLQESEKPKTEII-KVDQSHSEDNTYQSLVEQLDQEREK-RWRAEQAENKLMDY 450
           ++ N    +E +K   E+  K+  + SE +  Q  V++L ++ E+ ++   Q +   +  
Sbjct: 179 TITN----EELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ- 233

Query: 451 IDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKA 510
            +E+ +   E  +         +++     R R  +G++     K++ + K+L  E  K 
Sbjct: 234 -EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR-EQEKE 291

Query: 511 KDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRE 570
             +QE  L+  + L +  E+M+ Q+ +    + ++ +E E K    +  ++     + RE
Sbjct: 292 LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKM-REQEEKMWRQEERLWEQEKQM-RE 349

Query: 571 REQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID 630
           +EQ  +  +    ++ E  +E E R    +  ++    +E  +EE++  +  K+ +E+ +
Sbjct: 350 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ---EEKMQEEERIREREKKMREEEE 406

Query: 631 VLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIK 690
            + +Q   ++ +       E + +Q  +         L + K  L W Q K  E    I 
Sbjct: 407 TMREQEEKMQKQEENMWEQEEKEWQQQR---------LPEQKEKL-WEQEKMQEQEEKIW 456

Query: 691 DLTCMVKEQKTKLAEVSKL-KQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLI 749
           +    +++Q+    +  K+ +QE     ++Q+   E  + D +QK    E    E+ + +
Sbjct: 457 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERL 516

Query: 750 SELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR---KTNE 806
            E   +      +R ++K+W  E   +     Q + K     E   RE E +R   K   
Sbjct: 517 REKEER------MREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570

Query: 807 SDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLD 866
            + + +R + + + +Q E +R+ ++ + E++E ++  +EK+ E E+   EQ +E   Q  
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ 630

Query: 867 EVL-----EKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQV 921
           E +     EK++   E+  + +++++ +E ++ E  +       K  ++ E +   E ++
Sbjct: 631 EEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKM 690

Query: 922 KEVKEKFENKEKKLKAERDK 941
           +E +EK   +E+K+  + +K
Sbjct: 691 REQEEKMRGQEEKMWGQEEK 710



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 114/588 (19%), Positives = 260/588 (44%), Gaps = 66/588 (11%)

Query: 450  YIDELHKHANEKEDIHSLAL----LTTDRLK-------EIIFRERNSKGQLEVMVHKLQN 498
            YI+EL K    + D  SL L    +T + LK       E +    + K ++++ V +L+ 
Sbjct: 160  YIEELTK----ERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKR 215

Query: 499  EIK--KLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA 556
            +++  K  +  ++    QE+  +    L +  +K+ +Q+ +    + RL +E E K    
Sbjct: 216  KLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERL-REQEGKMREQ 274

Query: 557  DREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEK 616
            + +   +R    R REQ ++L +    +E+E R++ + RE   +   Q+   K   +EEK
Sbjct: 275  EEK---MRRQEKRLREQEKELRE----QEKELREQKKLRE--QEEQMQEQEEKMWEQEEK 325

Query: 617  KHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALI 676
              EQ  K ++++  +  Q+    E E ++    E    QD +   +    E    +   +
Sbjct: 326  MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK----EERMREQEKM 381

Query: 677  WAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSI 736
            W Q ++ +    I++    ++E++  + E  +  Q+   N+  Q           ++K  
Sbjct: 382  WEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ-----------EEKEW 430

Query: 737  QIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSR 796
            Q + L  +K +L  +   +E        E K+W  E             K+  Q E   +
Sbjct: 431  QQQRLPEQKEKLWEQEKMQEQ-------EEKIWEQE------------EKIRDQEEMWGQ 471

Query: 797  ENECLRKTN-ESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQ 855
            E +  R+       D +  + + + DQ + +   ++ + E+DE ++  +E++ E +K  Q
Sbjct: 472  EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQ 531

Query: 856  EQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLC 915
            ++   +  +  +  EK     E K + +++++ +E ++ E  +       K  ++ E + 
Sbjct: 532  QEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMR 591

Query: 916  HLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQA-- 973
              E ++ E +EK + +E+K+  + +K  E ++   +K+   ++    Q + + E  +   
Sbjct: 592  EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE--DKMQEQEEMMWEQEEKMQEQEEKMW 649

Query: 974  EIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 1021
            E  +   E+++ +     K+   E++MRE  E+    ++ M  + +++
Sbjct: 650  EQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKM 697


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score =  102 bits (255), Expect = 1e-21
 Identities = 116/540 (21%), Positives = 249/540 (46%), Gaps = 39/540 (7%)

Query: 441 EQAENKLMDYIDELH---KHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQ 497
           +Q E +  D I  LH   K A E E   +L+ + T + K   + E  +K +  + +   +
Sbjct: 215 KQLEGEARDLISRLHDSWKFAGELEQ--ALSAVATQKKKADRYIEELTKERDALSLELYR 272

Query: 498 NEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAAD 557
           N I    ++   AK Q++  L      E  L   E +++ ++A  +   Q+++ +A    
Sbjct: 273 NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 332

Query: 558 REIYLLRTSLHREREQAQQLHQLLALKEQEH-RKELETREFFTDADFQDALAKEIAKEEK 616
           +E+  +   L  + E+ +  ++L   +E++  R+E + +E+      Q+   +E  +EEK
Sbjct: 333 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE--QEEK 390

Query: 617 KHEQMIK-EYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHAL 675
             EQ  K   QE++    ++ M  + E       + RR +++    E    EL +  H  
Sbjct: 391 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 450

Query: 676 IWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKS 735
              + +E +     K     ++EQ+ +  + +K+ ++     + +I   E  I + ++K 
Sbjct: 451 EKIREQEEKRQEEEK-----IREQEKRQEQEAKMWRQ-----EEKIREQEEKIREQEEKM 500

Query: 736 IQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLS 795
            + E   HE+ ++  E   +E      + E+     E+ +Q   + +   K+  Q E + 
Sbjct: 501 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMW 560

Query: 796 RENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQ 855
           R+ E +    E            I +Q E + + ++ ++E++E I+  +EKI E E+ TQ
Sbjct: 561 RQEEKMHDQEEK-----------IREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQ 609

Query: 856 EQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLC 915
           EQ ++   Q +++ E+ E+  E++EK+++Q    E ++ E  K       K  ++ E++ 
Sbjct: 610 EQEEKMGEQEEKMCEQEEKMQEQEEKMRRQ----EEKIREQEKKIREQEEKIREQEEMMQ 665

Query: 916 HLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEI 975
             E ++ E +EK   +E+K++ + +K     +   EK+   +   ++Q + + E HQ  +
Sbjct: 666 EQEEKMWEQEEKMCEQEEKMQEQEEK----MRRQEEKMWEQEVRLRQQEEKMQE-HQEHL 720



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 116/541 (21%), Positives = 243/541 (44%), Gaps = 91/541 (16%)

Query: 433 EREKRWRAEQAENKLMD-YIDELHKHANEKEDIHSLAL----LTTDRLKEIIFRERNSKG 487
           E E+   A   + K  D YI+EL K    + D  SL L    +T + LKE   + +    
Sbjct: 237 ELEQALSAVATQKKKADRYIEELTK----ERDALSLELYRNTITDEELKEKNAKLQEKLQ 292

Query: 488 QLEVMVHKLQNEIKKLTVELMKAK--------DQQEDHL-KHLRTLEKTLE--------- 529
            +E    ++Q  +K+L  +L +AK          + DHL K L+++   L+         
Sbjct: 293 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 352

Query: 530 -KMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEH 588
            ++ +Q+ ++   Q   IQE E K    + +I      +  + E+ ++  +++  KE++ 
Sbjct: 353 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 412

Query: 589 RKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALT 648
           R+             Q+ +  E  ++ ++ E+M+ E +EKI  L ++  + E        
Sbjct: 413 RR-------------QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE-------- 451

Query: 649 VEARRFQDVKDGFENVAT-ELAKSKHALIWAQRKE-NESSSLIKDLTCMVKEQKTKLAEV 706
            + R  ++ +   E +   E  + + A +W Q ++  E    I++    +  Q+ K+ E 
Sbjct: 452 -KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQ 510

Query: 707 SKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTER 766
            K+++E     Q ++   E  I + ++   Q E + HE+ + I +   K       R E 
Sbjct: 511 EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKI-HEQEEKIRKQEEKM-----WRQEE 564

Query: 767 KVWGHE--LAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTE 824
           K+   E  + +Q   + +   K+  Q E +  + E +R+  E   +    + + + +Q E
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQE----QEEKMGEQEE 620

Query: 825 TIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVL--------EKLERHN 876
            + + ++ +QE++E ++R +EKI E EK  +EQ +EK  + +E++        E+ E+  
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ-EEKIREQEEMMQEQEEKMWEQEEKMC 679

Query: 877 ERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLK 936
           E++EK+++Q                    K   + E +   E ++++ +EK +  ++ L+
Sbjct: 680 EQEEKMQEQ------------------EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721

Query: 937 A 937
           A
Sbjct: 722 A 722



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 74/328 (22%), Positives = 155/328 (47%), Gaps = 35/328 (10%)

Query: 696  VKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAK 755
            +KE+  KL E  +L +   + +Q  +  L+  +E  K    Q + L+ E   L  EL + 
Sbjct: 280  LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ-QQLQAEADHLGKELQSV 338

Query: 756  ESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIK 815
             + +     E ++W     QQ   + +   K++   E +  + E +R+  E         
Sbjct: 339  SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK-------- 390

Query: 816  CKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERH 875
               I +Q E +R+ ++ + EK+E ++R +E + E E+  + Q +E   + +E + +LE  
Sbjct: 391  ---IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ-EEMMWEKEEKIRELEEK 446

Query: 876  NERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKL 935
               +EK+++Q + K  E E+IR+       K  ++   +   E +++E +EK   +E+K+
Sbjct: 447  MHEQEKIREQ-EEKRQEEEKIRE-----QEKRQEQEAKMWRQEEKIREQEEKIREQEEKM 500

Query: 936  KAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQ 995
              + +K  E +K   E+     +   RQ + I E       ++  +K+        K+H+
Sbjct: 501  WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE-----EIWRQKE--------KIHE 547

Query: 996  IEKEMRELLEETCKNKKTM---EAKIKQ 1020
             E+++R+  E+  + ++ M   E KI++
Sbjct: 548  QEEKIRKQEEKMWRQEEKMHDQEEKIRE 575



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 76/387 (19%), Positives = 172/387 (44%), Gaps = 15/387 (3%)

Query: 415 QSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR 474
           Q+  E+N   + + Q  Q+ EK WR E+   +  + I E  +   E+E+          R
Sbjct: 343 QAQVEENELWNRLNQ--QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 400

Query: 475 LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ 534
            +E+++ +     + E M+ + + ++++    + + +++  +  + +   EK  E+ E++
Sbjct: 401 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 460

Query: 535 KRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRERE----QAQQLHQLLALKEQEHRK 590
           + +++  +    QE E K    + +I      +  + E    Q +++H+   ++E+E R+
Sbjct: 461 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQ 520

Query: 591 ELETREFFTDADFQDALAKEIAKEEKKHEQ--MIKEYQEKIDVLSQQYMDLENEFRIALT 648
           E E  E +   +      +   ++EK HEQ   I++ +EK+    ++  D E + R    
Sbjct: 521 EQE--EMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEE 578

Query: 649 VEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSK 708
              R+ + +++  E +  +  K +      Q +E E     ++  C  +E+  +  E  +
Sbjct: 579 KVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE-EKMGEQEEKMCEQEEKMQEQEEKMR 637

Query: 709 LKQETAANLQNQINTLEILIEDDKQKSIQIE--LLKHEKVQLISELAAKESLIFGLRTER 766
            ++E     + +I   E  I + ++   + E  + + E+     E   +E      R E 
Sbjct: 638 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 697

Query: 767 KVWGHE--LAQQGSSLAQNRGKLEAQI 791
           K+W  E  L QQ   + +++  LEA I
Sbjct: 698 KMWEQEVRLRQQEEKMQEHQEHLEAAI 724



 Score = 31.6 bits (70), Expect = 4.0
 Identities = 51/339 (15%), Positives = 136/339 (40%), Gaps = 28/339 (8%)

Query: 278 QSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDY 337
           +  E  +   E   + E K+++ ++ + +   +     + + EK+ + +R  ++  E + 
Sbjct: 379 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 438

Query: 338 GNRKECNRKVPRRSKIPYDAKTIQT---IKHHNKNYNSFVSCNRKMKPPYLKELYVSSSL 394
             R E   K+  + KI    +  Q    I+   K         R+ +    +E  +    
Sbjct: 439 KIR-ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 497

Query: 395 ANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQA----------- 443
                 +E    + +I + ++   ++  ++   E+  +E+E+ WR ++            
Sbjct: 498 EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ--EEKIREQEEIWRQKEKIHEQEEKIRKQ 555

Query: 444 ENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKL 503
           E K+    +++H    +  +         ++++E   + R  + ++       Q + +K+
Sbjct: 556 EEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKM 615

Query: 504 TVELMKAKDQQEDHLKHLRTLEKTLEKMERQKR--QQQAAQIR----LIQEVELK----- 552
             +  K  +Q+E   +    + +  EK+  Q++  ++Q  +IR    ++QE E K     
Sbjct: 616 GEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 675

Query: 553 ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKE 591
               ++E  +        R++ +   Q + L++QE + +
Sbjct: 676 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
          Length = 1116

 Score =  100 bits (250), Expect = 5e-21
 Identities = 144/702 (20%), Positives = 291/702 (41%), Gaps = 103/702 (14%)

Query: 400  LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHAN 459
            LQ+  + + ++ ++ Q  S   T +  V +L +E  +R  AE               H  
Sbjct: 232  LQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE---------------HER 276

Query: 460  EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 519
            + +++     L    L+E+  R    K  L      ++  ++ L  + + AK  +EDH +
Sbjct: 277  QAKEL----FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332

Query: 520  ---------HLRTLEKTLEKMERQ---------KRQQQAAQIRLIQEVELKASAADREIY 561
                     H+  LE  LE+ E++         +R + A      + ++      D +I 
Sbjct: 333  TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392

Query: 562  LLRTSLHREREQAQQLHQLLALKEQEHRKELETREFF-TDADFQ----DALAKEIAKEEK 616
             +   L    E+ Q L    AL  +E  +E++  E + + + F     + L +E++ +E 
Sbjct: 393  SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEA 452

Query: 617  KHEQMIKE---YQEKIDVLSQQYMDLENEF---RIALTVEARRFQDVKDGFENVATEL-A 669
            + E++ K+    Q +I  + Q+    + E    +  L     +F D K   E +   L A
Sbjct: 453  QWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 512

Query: 670  KSKHALIWA----------QRKENESSSLIKDLTCMVKEQKTKLAEVSKLK--------- 710
            K + A I            + KE   +   K +  M +E+ T+  E+  LK         
Sbjct: 513  KEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 572

Query: 711  ----QETAANLQNQINTLEILIEDDKQ--KSIQIELLKHEKVQLISE--LAAKESLIFGL 762
                Q+   NLQ Q+   E  +   K+  KS+Q +    +      E  LA KE  I  L
Sbjct: 573  VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 632

Query: 763  RTERKVWGHELAQQGSSLAQNRGKLEAQIE----SLSRENECLRKTNESDSDALRIKCKI 818
            + +R     E  ++  +  ++   L+ ++      LS +   L    E  S       K 
Sbjct: 633  KEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK- 691

Query: 819  IDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSS-QLDEVLEKLERHNE 877
               +   ++ L+  L++K E   +++   ++++K  +  L+ ++S ++ + ++ LER   
Sbjct: 692  ---KDSRLKTLEIALEQKKEECLKME---SQLKKAHEAALEARASPEMSDRIQHLEREIT 745

Query: 878  RKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKA 937
            R    K +    + E++ + +    +  + +DK + +  LE QVK+  +K  N + K + 
Sbjct: 746  R---YKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQV 802

Query: 938  ERDKSIEL-------QKNAMEKLHSMDDAFKRQVDAIVEAHQA--EIAQLANEKQKCIDS 988
            E+ KS ++       + N  +    + D+ +++ D I E  +A  E  Q+  E++  +  
Sbjct: 803  EKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQ 862

Query: 989  ANLKVHQIEKEMRELL---EETCKNKKTMEAKIKQLAFALNE 1027
                    EK++ ELL   E+  +  ++M+AK+     +L E
Sbjct: 863  EESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAE 904



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 125/609 (20%), Positives = 260/609 (42%), Gaps = 72/609 (11%)

Query: 395 ANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQE---REKRWRAEQAENKLMDYI 451
           +N  +  E  + + + ++V +SHS+    ++ VEQL +E   +E +W  E+ + K     
Sbjct: 410 SNGALSTEEREEEMKQMEVYRSHSK--FMKNKVEQLKEELSSKEAQW--EELKKKAAGLQ 465

Query: 452 DELHKHANE--KEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMK 509
            E+ +   E  ++D   LAL T  +L+ +  +  +SK  +EV+   L  + ++  + L  
Sbjct: 466 AEIGQVKQELSRKDTELLALQT--KLETLTNQFSDSKQHIEVLKESLTAKEQRAAI-LQT 522

Query: 510 AKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHR 569
             D     L+   T+     K  +   +++  Q   I +++      +R++ +L+  +  
Sbjct: 523 EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN 582

Query: 570 EREQAQQLH-QLLALKEQEHRKELETREFFTD-ADFQDALAKEIAKEEKKHEQMIK---E 624
            +EQ +    Q+ +LKE+    + +T    T     ++ALA++    E+  EQ  +   E
Sbjct: 583 LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE 642

Query: 625 YQEKIDVLSQQYMDLENEFRIA---LTVEARRFQDVKDGFENVATELAKSKHALIWAQRK 681
            QE+ID   +   DL+ +  +    L+ +     D+K+   ++A+   K    L     K
Sbjct: 643 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL-----K 697

Query: 682 ENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELL 741
             E +   K   C+  E + K A  + L+   +  + ++I  LE  I   K +S + +  
Sbjct: 698 TLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAE 757

Query: 742 KHEKVQLISELAA----KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRE 797
               ++++ E+      K+  I  L  + K    ++A         + K    +E   R 
Sbjct: 758 VDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR 817

Query: 798 NECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI-----------KRLQEK 846
            + L  +++   D+LR K   I++  E +R+      E++  +           K+++E 
Sbjct: 818 EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL 877

Query: 847 ITEIEKC-------------TQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVEL 893
           +  +EK              TQ+ L EK + L  +  +  +H E   ++KQ         
Sbjct: 878 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQ--------- 928

Query: 894 EEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSI-ELQKNAMEK 952
           E +  A S       +K   +  LE  +   K+K + +   LK E+D+ + +L++    +
Sbjct: 929 EALLAAIS-------EKDANIALLE--LSSSKKKTQEEVAALKREKDRLVQQLKQQTQNR 979

Query: 953 LHSMDDAFK 961
           +  M D ++
Sbjct: 980 MKLMADNYE 988



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 44/304 (14%)

Query: 294 EIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKR-------DTDITSESDYGNRKECNRK 346
           EI L++  ++ L++ ++   + +  LE    P+        + +IT   D  ++ +   +
Sbjct: 700 EIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQA--E 757

Query: 347 VPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKP 406
           V R  +I    K ++  K  N          R++K    K       +AN    ++ EK 
Sbjct: 758 VDRLLEI---LKEVENEK--NDKDKKIAELERQVKDQNKK-------VANLKHKEQVEKK 805

Query: 407 KTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHS 466
           K+  +  +    EDN   S  +  D  R+K  R E+ E  L + +               
Sbjct: 806 KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ-------------- 851

Query: 467 LALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEK 526
              +T +R + ++ +E +++   E  V +L   ++K+  EL   K +     + L   E 
Sbjct: 852 ---ITAER-EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET 907

Query: 527 TLEKMERQKRQQQAAQIRLIQEVELKA-SAADREIYLLRTSLHREREQAQQLHQLLALKE 585
            L  +  ++R+     + + QE  L A S  D  I LL  S  +++ Q     ++ ALK 
Sbjct: 908 HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQ----EEVAALKR 963

Query: 586 QEHR 589
           ++ R
Sbjct: 964 EKDR 967



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 63/295 (21%), Positives = 117/295 (39%), Gaps = 65/295 (22%)

Query: 787  LEAQIESLSRENECLRKTNESD---------------SDALRIKCKIIDDQTETIRKLKD 831
            L+ Q++ + REN+ LRK  E                 S  L+ +  +  D+   I   K+
Sbjct: 154  LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213

Query: 832  ---CLQEKDEHIK----------RLQEKITEI----------EKCTQEQLDEKSSQLDEV 868
                +QE+++H++          R+Q  + ++          E C  E  +E   +L   
Sbjct: 214  QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273

Query: 869  LEK-----------LERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKW---------H 908
             E+           LE    R E  KQ L  ++   E I+K    L  K          H
Sbjct: 274  HERQAKELFLLRKTLEEMELRIETQKQTLNARD---ESIKKLLEMLQSKGLSAKATEEDH 330

Query: 909  DKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAME--KLHSMDDAFKRQVDA 966
            ++   L   E  V  ++   E KEK+    R++     +NA +  K  ++    + + D+
Sbjct: 331  ERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK-DS 389

Query: 967  IVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 1021
             + + +  +  L  E Q    +  L   + E+EM++ +E    + K M+ K++QL
Sbjct: 390  KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ-MEVYRSHSKFMKNKVEQL 443


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  100 bits (250), Expect = 5e-21
 Identities = 164/753 (21%), Positives = 315/753 (41%), Gaps = 74/753 (9%)

Query: 319  LEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNR 378
            +E +   K+   + SE D  + +  + K      +   A    T KH N+     V+   
Sbjct: 1733 MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN---VTEEG 1789

Query: 379  KMKPPYLKELYVSSSLANCPMLQES----EKPKTEIIKVDQSHSEDNTYQSLVEQLDQER 434
                P   E   S S++  P   ES    +     + K   SH E N Y   ++Q+DQ +
Sbjct: 1790 TQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNY---LQQIDQLK 1846

Query: 435  EKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVH 494
            E+    E+ + K  ++   L    NEK  + S        LK  + +E  +K  + ++  
Sbjct: 1847 ERIAGLEEEKQKNKEFSQTLE---NEKNTLLSQISTKDGELK--MLQEEVTK--MNLLNQ 1899

Query: 495  KLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKAS 554
            ++Q E+ ++T     A+++++D       LE+ L     +         + + + ++K  
Sbjct: 1900 QIQEELSRVTKLKETAEEEKDD-------LEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952

Query: 555  AADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKE-LETREFFTDADFQDALAKEIAK 613
              + E+  L+  +    E+ QQL +     E E RKE LE  +         + AKE+ +
Sbjct: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE 2012

Query: 614  EEKKHEQMIKE-------YQEKIDVLSQQYMDLE---NEFRIALTVEARRFQDVKDGFEN 663
              K+ +Q +K+       YQEKI  L +    LE    E +  L +         +  + 
Sbjct: 2013 LLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKK 2072

Query: 664  VATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINT 723
               ELA  K  L      ++E++ ++ D   + KE ++    V    ++   +L+ ++  
Sbjct: 2073 AQAELASFKVLL---DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129

Query: 724  LEIL-IEDDKQKSIQIELLKHEKVQL---ISELAA----KESLIFGLRTERKVWGHELAQ 775
             E   +++ K    +++ L+ EKV L   I E+      K+  +  L+        +LA 
Sbjct: 2130 AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAA 2189

Query: 776  QGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIK---CKIIDDQTETIRKLKDC 832
               S++  +   +  I+   +         +S  + +R+K   C ++ DQ   +R++   
Sbjct: 2190 FTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQ---LRQMSIH 2246

Query: 833  LQEKDEHIKRLQ--EKITEIEKCTQEQLDEK-----SSQLDEVLEKLER-----HNERKE 880
            ++E   +I RL+  ++I E +  T+ QL +K       +  E+L +LE      H+ + E
Sbjct: 2247 MEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNE 2306

Query: 881  --KLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAE 938
              KL+ +LK  + +L ++  +      +  +   ++   E  ++  K  +E  E  L+A 
Sbjct: 2307 LAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS 2366

Query: 939  RDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEK 998
            R    EL     E+++  +      +    EA Q  IA+L  +  K I      + Q E+
Sbjct: 2367 R----ELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE 2422

Query: 999  EMRELLEETCKNKKTMEAKIKQLAFALNEIQQD 1031
            E   L EE   NKK ++ K  QL   L  I+++
Sbjct: 2423 ENIVLEEE---NKKAVD-KTNQLMETLKTIKKE 2451



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 167/795 (21%), Positives = 342/795 (43%), Gaps = 110/795 (13%)

Query: 292  QNEIKLQKLDDQILQLLNETSNSIDNVLE--KDPRPKRDTDITSESDYGNRKECNRKVPR 349
            Q E++ ++ D++I QL  E         E  ++ R K+      ++   +RKE  ++   
Sbjct: 1442 QLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKS 1501

Query: 350  -RSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKT 408
             + ++     TI+ +     +  S VS   K K   L  L          +LQE E+ K 
Sbjct: 1502 LQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRL---------ALLQE-ERDKL 1551

Query: 409  EIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHK----HANEKEDI 464
             I ++D+S  E+ +  S  E L    E      + + KL+  I+ L       + E ++ 
Sbjct: 1552 -ITEMDRSLLENQSLSSSCESLKLALEG---LTEDKEKLVKEIESLKSSKIAESTEWQEK 1607

Query: 465  HSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTL 524
            H       + L +      N   +++ +V  ++ E ++L  +L   +  +++  K L+  
Sbjct: 1608 HKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA 1667

Query: 525  EKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL--- 581
            E+ +E+M+ + R+   ++ + I E+E        E   LR  +H   + A++  + L   
Sbjct: 1668 EQEMEEMKEKMRKFAKSKQQKILELE-------EENDRLRAEVHPAGDTAKECMETLLSS 1720

Query: 582  --ALKEQEHRKELE----TREFFTDADFQDALAKEIAKEEKKHE-------QMIKEYQEK 628
              ++KE+  R ++E    +++F +    +D+L++E+  ++ KH+       Q   E  EK
Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEV--QDLKHQIEGNVSKQANLEATEK 1778

Query: 629  IDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSL 688
             D       ++  E   ++  E      +        +E   S  +   A  K+  S   
Sbjct: 1779 HD----NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834

Query: 689  IKDLTCMVKEQKTKLAEVSKLKQ---ETAANLQNQINTL--EILIEDDKQKSIQIELLKH 743
            I +    + + K ++A + + KQ   E +  L+N+ NTL  +I  +D + K +Q E+ K 
Sbjct: 1835 INNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894

Query: 744  EKV--QLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKL-----EAQIESLSR 796
              +  Q+  EL+    L      E+      L  Q + L  + G       +AQI++   
Sbjct: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELL 1954

Query: 797  ENE------CLRKTNESDSDALRIKCKIIDD-----------------QTETIRKLKDCL 833
            E+E      C+ +  E     ++ K K+  +                      ++L++ L
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL 2014

Query: 834  QEKDEHIKRLQ-------EKITEIEKCTQEQLD----EKSSQLDEVLEKLERHNERKEKL 882
            +EK + +K+LQ       EKI+ +E+ T + L+    E    L+   E L +  E ++K 
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALER-TVKALEFVQTESQKDLEITKENLAQAVEHRKKA 2073

Query: 883  KQQLKGKEVELEEIR-KAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDK 941
            + +L   +V L++ + +A   L      K EL  + E+   ++K+K E+ E++L+   +K
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133

Query: 942  SIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMR 1001
             ++ +KN  EKL    DA +R+        +  + +   E Q  ++  + +V Q+++ + 
Sbjct: 2134 HLKEKKNMQEKL----DALRRE--------KVHLEETIGEIQVTLNKKDKEVQQLQENLD 2181

Query: 1002 ELLEETCKNKKTMEA 1016
              + +     K+M +
Sbjct: 2182 STVTQLAAFTKSMSS 2196



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 119/543 (21%), Positives = 227/543 (41%), Gaps = 64/543 (11%)

Query: 492  MVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVEL 551
            + H  QNE+ KL  EL   KDQ  D       L  +LEK + QK   +   I   QE ++
Sbjct: 2299 LYHSSQNELAKLESELKSLKDQLTD-------LSNSLEKCKEQKGNLEG--IIRQQEADI 2349

Query: 552  KASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEI 611
            + S    E   L T L   RE   +LH+ + +KEQ+    L  +E        +A+   I
Sbjct: 2350 QNSKFSYE--QLETDLQASRELTSRLHEEINMKEQKIISLLSGKE--------EAIQVAI 2399

Query: 612  AKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKS 671
            A+  ++H++ IKE +  +    ++ + LE E + A+    +  + +K   +    + A+ 
Sbjct: 2400 AELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL 2459

Query: 672  KHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAA---NLQNQINTLEILI 728
               +      +N+   ++ D   + +   + + E  +L QE AA    L+ +I  L   +
Sbjct: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519

Query: 729  ED--DKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGK 786
            +D   +   +  EL+++ +  L   +  K+S       ++K       QQ   L     K
Sbjct: 2520 DDLNSENAKLDAELIQYRE-DLNQVITIKDS-------QQKQLLEVQLQQNKELENKYAK 2571

Query: 787  LEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEK 846
            LE +++     NE LR++  +  +  +       D ++ I  LK  + +    +  LQE+
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQEEKQ-------DLSKEIESLKVSISQLTRQVTALQEE 2624

Query: 847  IT-----EIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYS 901
             T        K  +E++   S+      +++    E    ++++   K  E+E+  K   
Sbjct: 2625 GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED--KLKK 2682

Query: 902  TLNRKWHDKGELLCHLET---QVKEVKEKFENKEKKL----KAERDKSIELQK--NAMEK 952
             L    HD G +    ET   +V E+       E+KL    K  +  + ++Q    +M  
Sbjct: 2683 ELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS 2742

Query: 953  LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKK 1012
            L +  D    ++D +   + A + +LA  K++ +         + +E   LL ET  +  
Sbjct: 2743 LQNSRDHANEELDELKRKYDASLKELAQLKEQGL---------LNRERDALLSETAFSMN 2793

Query: 1013 TME 1015
            + E
Sbjct: 2794 STE 2796



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 98/476 (20%), Positives = 209/476 (43%), Gaps = 42/476 (8%)

Query: 493  VHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELK 552
            V +LQ +I K  +E+   K    +   H  +L++ LE       Q Q A +  ++E++ K
Sbjct: 1339 VFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESS-----QLQIAGLEHLRELQPK 1393

Query: 553  ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIA 612
                      L+  + ++ E    L   L+ KE    K ++T E     D   AL  ++ 
Sbjct: 1394 LDE-------LQKLISKKEEDVSYLSGQLSEKEAALTK-IQT-EIIEQEDLIKALHTQLE 1444

Query: 613  KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEAR-------RFQDVKDGFENVA 665
             + K+H++ IK+ Q ++  + Q+  ++  E R    ++ +       R + +K+  +++ 
Sbjct: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN-KSLQ 1503

Query: 666  TELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTL- 724
             EL+ ++  +   +R     + +   ++   KE+ T L  ++ L++E    +     +L 
Sbjct: 1504 EELSLARGTI---ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL 1560

Query: 725  --EILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQ 782
              + L    +   + +E L  +K +L+ E+ + +S      TE +    EL ++   L Q
Sbjct: 1561 ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ 1620

Query: 783  NRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRK-LKDCLQEKDEHIK 841
            +   +  + E +    E +R+  +     LR         TE  +K  +  LQE ++ ++
Sbjct: 1621 SYENVSNEAERIQHVVEAVRQEKQELYGKLR--------STEANKKETEKQLQEAEQEME 1672

Query: 842  RLQEKITEIEKCTQEQLDEKSSQLDEVLEKL----ERHNERKEKLKQQLKGKEVELEEIR 897
             ++EK+ +  K  Q+++ E   + D +  ++    +   E  E L       + ELE ++
Sbjct: 1673 EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK 1732

Query: 898  KAYSTLNRKWHDKGELLCHLETQVKEVKEKFE-NKEKKLKAERDKSIELQKNAMEK 952
              Y TL++K+         L  +V+++K + E N  K+   E  +  + Q N  E+
Sbjct: 1733 MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEE 1788



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 167/822 (20%), Positives = 344/822 (41%), Gaps = 126/822 (15%)

Query: 292  QNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRS 351
            Q E+++ K+D  +L+   +       + EKD +        +E  +   ++  +    + 
Sbjct: 870  QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQ-------VTEISFSMTEKMVQLNEEKF 922

Query: 352  KIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEII 411
             +  + KT++      +  N         K    ++  VSS L       +   P  +I 
Sbjct: 923  SLGVEIKTLK------EQLNLLSRAEEAKKEQVEEDNEVSSGL---KQNYDEMSPAGQIS 973

Query: 412  KVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENK-LMDYIDELHKH-ANEKEDIHSLAL 469
            K +  H  D     L+++ +++R+++ +A     K L+  +  L +  AN K++      
Sbjct: 974  KEELQHEFD-----LLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIP 1028

Query: 470  LTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLR-TLE--- 525
            L+     E+   + N +   + +  K Q    ++ + L +   ++E  L+H+R  LE   
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQ----EIEIYLKQTISEKEVELQHIRKDLEEKL 1084

Query: 526  ------KTLEKMERQKRQQQAAQIRLIQE------------VELKASAADRE-IYLLRTS 566
                  + L K   Q  Q +  QI L+Q             +     A+D + + L++ +
Sbjct: 1085 AAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKET 1144

Query: 567  L--------HREREQAQQLHQLLALKEQEHRKELETREFFTD--ADFQDALAKE--IAKE 614
            +          E  + +   ++LAL++++ + + + +E  T   A  + A  KE  + +E
Sbjct: 1145 VVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREE 1204

Query: 615  EKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVK-------------DGF 661
             K+ +      QE+ D  S++  ++ ++ R  L ++ R   D K              G 
Sbjct: 1205 LKQQKDDYNRLQEQFDEQSKENENIGDQLR-QLQIQVRESIDGKLPSTDQQESCSSTPGL 1263

Query: 662  ENVATELAKSKHAL---------IWAQRKENESS----SLIKDLTCMVKEQKTKLAEVSK 708
            E    +  +  H            W    E+ S+    + +  +   +KE + +  E+  
Sbjct: 1264 EEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELEL 1323

Query: 709  LKQETAANLQNQINTLEILIEDDKQKSIQIELLK---HE----KVQLISELAAKESLIFG 761
                T + L  +   +  L E   ++ ++IE LK   HE       L  +L + +  I G
Sbjct: 1324 KVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAG 1383

Query: 762  LRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDD 821
            L   R     EL  +   L +   K E  +  LS +       +E ++   +I+ +II +
Sbjct: 1384 LEHLR-----ELQPKLDELQKLISKKEEDVSYLSGQ------LSEKEAALTKIQTEII-E 1431

Query: 822  QTETIRKLKDCLQ----EKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERH-N 876
            Q + I+ L   L+    E DE IK+LQ ++ E+ K   E++ E+S    ++  KL+    
Sbjct: 1432 QEDLIKALHTQLEMQAKEHDERIKQLQVELCEM-KQKPEEIGEESRAKQQIQRKLQAALI 1490

Query: 877  ERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLK 936
             RKE LK+    K ++ EE+  A  T+ R      ++   +  Q KE K+    +   L+
Sbjct: 1491 SRKEALKE---NKSLQ-EELSLARGTIERLTKSLADVESQVSAQNKE-KDTVLGRLALLQ 1545

Query: 937  AERDKSI-ELQKNAME--KLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSA---N 990
             ERDK I E+ ++ +E   L S  ++ K  ++ + E  +  + ++ + K   I  +    
Sbjct: 1546 EERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQ 1605

Query: 991  LKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 1032
             K  +++KE  E+L ++ +N      +I+ +  A+ + +Q++
Sbjct: 1606 EKHKELQKEY-EILLQSYENVSNEAERIQHVVEAVRQEKQEL 1646



 Score = 73.9 bits (180), Expect = 7e-13
 Identities = 146/760 (19%), Positives = 319/760 (41%), Gaps = 128/760 (16%)

Query: 292  QNEIKLQK-----LDDQILQLLNETSNSIDNV--LEKDPR---PKRDTDITSESDYGNRK 341
            + EI+L++     L DQ+ Q+         N+  LE D +    K  T++  +     +K
Sbjct: 2223 EEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQ-----QK 2277

Query: 342  ECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQ 401
             C+       ++    +  + + H ++N  + +    K     L +L  S+SL  C   +
Sbjct: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL--SNSLEKC---K 2332

Query: 402  ESEKPKTEIIKVDQSHSEDN--TYQSLVEQLDQEREKRWRAEQAENKLMDYIDEL----- 454
            E +     II+  ++  +++  +Y+ L   L   RE   R  +  N     I  L     
Sbjct: 2333 EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKE 2392

Query: 455  -----------HKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKL 503
                        +H  E +++ +L  L+ +  + I+  E N K   +   ++L   +K +
Sbjct: 2393 EAIQVAIAELRQQHDKEIKELENL--LSQEEEENIVLEEENKKAVDKT--NQLMETLKTI 2448

Query: 504  TVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQI-------RLIQEVELKASAA 556
              E ++ K Q +  +K + +L+   +++    +Q +   +       +LIQE   + +  
Sbjct: 2449 KKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKL 2508

Query: 557  DREIYLLRT---SLHRER--------EQAQQLHQLLALKEQEHRKELETREFFTDADFQD 605
              EI  LR+    L+ E         +  + L+Q++ +K+ + ++ LE  +   + + ++
Sbjct: 2509 KEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV-QLQQNKELEN 2567

Query: 606  ALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEF---RIALTVEARRFQDVKD--- 659
              AK + ++ K+ E+  ++ +   + L ++  DL  E    +++++   R+   +++   
Sbjct: 2568 KYAK-LEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626

Query: 660  -GFENVATELAKSKHALIWA--QRKENESSSLIKDLTCMVKEQKTKLAEVS-KLKQET-- 713
             G  +   ++ + +   + A     +   + L ++L C+ KE   K+ E+  KLK+E   
Sbjct: 2627 LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKH 2686

Query: 714  ----AANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVW 769
                A  ++N+  T E  + +  +  +++E    +K+ +++    KE+   GL  + + +
Sbjct: 2687 LHHDAGIMRNETETAEERVAELARDLVEME----QKLLMVT----KENK--GLTAQIQSF 2736

Query: 770  GHELAQQGSSLAQNRGKLEAQIESLSRENEC----LRKTNES-----DSDALRIKCKIID 820
            G  +    SSL  +R     +++ L R+ +     L +  E      + DAL  +     
Sbjct: 2737 GRSM----SSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792

Query: 821  DQTET-----IRKLKDCLQEKDEHIKRLQEKITEIEKCTQE------QLDEKSSQLDEVL 869
            + TE      + KL   L  KDE +  L  ++ +     Q        L  +   L   L
Sbjct: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNEL 2852

Query: 870  EKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLE----------- 918
            EK  +  E K++   Q      E++ ++KA S+L    +D+  LL  L+           
Sbjct: 2853 EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQ---NDRDRLLKELKNLQQQYLQINQ 2909

Query: 919  --TQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSM 956
              T++  +K + +  + K KA +    EL++  +   H +
Sbjct: 2910 EITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHEL 2949



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 160/827 (19%), Positives = 336/827 (40%), Gaps = 117/827 (14%)

Query: 292  QNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRS 351
            Q +++LQ+ D+     L E   + DN ++K  +      +TS + Y        K    +
Sbjct: 70   QKDVQLQQKDEA----LQEERKAADNKIKK-LKLHAKAKLTSLNKYIEEM----KAQGGT 120

Query: 352  KIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYL-KELYVSSSLANCPMLQ-----ESEK 405
             +P + ++ + +  H+K+         K+K     KE  +S+  A     Q     +S  
Sbjct: 121  VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSST 180

Query: 406  PKTEIIKVDQSHSEDNTYQSLVE-QLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDI 464
               E + + Q   E   + S ++ QL Q + ++   +    K   +  ++  H +E   +
Sbjct: 181  EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL 240

Query: 465  HSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTL 524
             + A + T+  +++   +R  +   E +V + Q  +  L  EL  A+ + +   + L+ +
Sbjct: 241  VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQ-VVDLLQQELTAAEQRNQILSQQLQQM 299

Query: 525  EKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLA-- 582
            E     +      ++     L++++EL+ +      + L+  +H   EQ +Q  Q  A  
Sbjct: 300  EAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAEL 359

Query: 583  -----LKEQEHRKELETREFF------TDADFQ---DALAKEIAKE-EKKHEQMIKEYQE 627
                   EQ+H+ E+E +         T  + Q   DAL  + +K  + K+EQ ++  Q 
Sbjct: 360  ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQT 419

Query: 628  KIDVLSQQYMDLENEF-----RIAL----TVEARRFQDV-KDGF-----ENVAT------ 666
             I  L  Q      E      R+ L    T     F DV  +G      EN+A+      
Sbjct: 420  -IQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVV 478

Query: 667  ELAKSKHALIWA----QRKENESSSLIKDLTCMVKEQKTKLA--EVSKLKQETAANLQN- 719
            EL   K AL+ +    +  + E+  L   +T +  + +T  A  EVS++     AN ++ 
Sbjct: 479  ELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSS 538

Query: 720  --QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQ- 776
              + +  ++L     QK  ++ +L  E  +   E+A  +  + G R E     HE+  Q 
Sbjct: 539  SAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEA--DHEVLDQK 596

Query: 777  ------GSSLAQNRGKL---------------EAQIESLSRENECL----RKTNESDSDA 811
                  G  +A  + K+               E+ + ++ +E        R + E   + 
Sbjct: 597  EMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLND 656

Query: 812  LRIKCKII-DDQTETIRKLKDCLQEKDEHIKRLQEKITEIE-------KCTQEQLDEKSS 863
              ++ K    D  +++  + D  Q   + ++RL+ +I E+E       +  ++ LDEK+ 
Sbjct: 657  AGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAK 716

Query: 864  QLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKE 923
            ++  + + +E   +  +           E +++      L+        ++  L  QVK+
Sbjct: 717  EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELS--------MVTELRAQVKQ 768

Query: 924  VKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLA---N 980
            ++      E++ + + +          E++HS+    K + D  +E  Q E+  +    +
Sbjct: 769  LEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSK-DVKIEVLQNELDDVQLQFS 827

Query: 981  EKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNE 1027
            E+   I S   ++   E E+ E  E      + + +K+++L+ AL++
Sbjct: 828  EQSTLIRSLQSQLQNKESEVLEGAERV----RHISSKVEELSQALSQ 870



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 115/636 (18%), Positives = 262/636 (41%), Gaps = 71/636 (11%)

Query: 425  SLVEQLDQEREKRWRAEQAENKL--------MDYIDELHKHANEKEDIHSLALLTTDRLK 476
            S V++L    E R + +Q E  L        +DY  +        E IHSL++    +  
Sbjct: 751  SQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDV 810

Query: 477  EIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKR 536
            +I   + N    +++   +    I+ L  +L   + +  +  + +R +   +E++  Q  
Sbjct: 811  KIEVLQ-NELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS-QAL 868

Query: 537  QQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQL-----HQLLALKEQEHRKE 591
             Q+  +I  + ++ L+     R++  L+ ++  + +Q  ++      +++ L E++    
Sbjct: 869  SQKELEITKMDQLLLEKK---RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLG 925

Query: 592  LETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEA 651
            +E +      +        +++ E+  ++ ++E  E    L Q Y ++    +I+     
Sbjct: 926  VEIKTLKEQLNL-------LSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978

Query: 652  RRFQDVKDGFEN----VATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVS 707
              F  +K   E     +   L   K  L    R E E ++L  +    +   +T+  EV 
Sbjct: 979  HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038

Query: 708  KLKQETAAN---LQNQINTLEILIEDD-KQKSIQIELLKHEKVQLISELAAKESLIFGLR 763
            + K+    +   + ++   +EI ++    +K ++   L+H +  L  +LAA+E       
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVE---LQHIRKDLEEKLAAEEQF----- 1090

Query: 764  TERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECL------RKTNESDSDALRIKCK 817
                     L +Q +   Q++      +++   EN+ +        T+ SD D++ +   
Sbjct: 1091 -------QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALV-- 1141

Query: 818  IIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEK----LE 873
                  ET+     C    +     L+EKI  +EK  +EQL +K   L E L      L+
Sbjct: 1142 -----KETVVISPPCTGSSEHWKPELEEKILALEK-EKEQLQKK---LQEALTSRKAILK 1192

Query: 874  RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKE-VKEKFENKE 932
            +  E++  L+++LK ++ +   +++ +   +++  + G+ L  L+ QV+E +  K  + +
Sbjct: 1193 KAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD 1252

Query: 933  KKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLK 992
            ++        +E       + H      +  +     +H  + + L          A LK
Sbjct: 1253 QQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLK 1312

Query: 993  VHQIEKEMRELLEETCKNKKTMEA-KIKQLAFALNE 1027
              + EK   EL   +  ++ T ++ ++ QL   +N+
Sbjct: 1313 EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINK 1348



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 100/548 (18%), Positives = 218/548 (39%), Gaps = 84/548 (15%)

Query: 547  QEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDA 606
            ++V+ + + A++ +  L+  + ++  Q QQ  + L    QE RK  + +           
Sbjct: 48   EDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL----QEERKAADNK----------- 92

Query: 607  LAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIAL-------TVEARRFQDVKD 659
              K++    K     + +Y E++       +  E +    L       T E    + +K 
Sbjct: 93   -IKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKH 151

Query: 660  GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQN 719
              +     ++  +  L  AQ ++   SS   +   M+K+Q  +  E     Q   +  Q 
Sbjct: 152  KLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQA 211

Query: 720  QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRT-ERKVWGHE------ 772
            +    +++ E D +   Q+ L + E +QL+++   +  +   LR  +RK+  HE      
Sbjct: 212  EQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGR 271

Query: 773  -----LAQQGSSLAQNRGK-LEAQIESLSRENECLRKTNESDSDALRIKCKIID------ 820
                 L QQ  + A+ R + L  Q++ +  E+  LR T E++ +  +I  + ++      
Sbjct: 272  AQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAER 331

Query: 821  ---------------DQTETI---------------RKLKDCLQEKDEHIKRLQEKITEI 850
                           +Q E                 +K K  ++EK  HI  LQ+   E+
Sbjct: 332  KLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQEL 391

Query: 851  EKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDK 910
            +       D+ S  L +  E+  +  +  ++L+ QL+ K    +EI +  + L  + H+ 
Sbjct: 392  QSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKS---KEISQFLNRLPLQQHET 448

Query: 911  GELLCHLE-----TQVKEVKEKFENKEKKLKAERDK-SIELQKNAMEKLHSMDDAFKRQV 964
                   +     TQ    +     +++ ++ E +K ++ L    +E+L + ++    Q+
Sbjct: 449  ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQI 508

Query: 965  DAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFA 1024
              +   ++   A     +   +D AN +    E+  +++LE T   K     ++  L   
Sbjct: 509  TLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQK---HKELSVLLLE 565

Query: 1025 LNEIQQDM 1032
            + E Q+++
Sbjct: 566  MKEAQEEI 573



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 163/848 (19%), Positives = 333/848 (39%), Gaps = 127/848 (14%)

Query: 224  LDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPE 283
            L+NL+S +   NI  +E   +    T  + E +   +  +    A L SF+    S + +
Sbjct: 2413 LENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND 2472

Query: 284  KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKEC 343
            ++    D Q      +L+++ L ++ E    I     ++ + K       E   G R   
Sbjct: 2473 RDRIVGDYQ------QLEERHLSIILEKDQLIQEAAAENNKLK-------EEIRGLRSHM 2519

Query: 344  NRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLK-ELYVSSSLANCPMLQE 402
            +      +K+  DA+ IQ    + ++ N  ++     +   L+ +L  +  L N     E
Sbjct: 2520 DDLNSENAKL--DAELIQ----YREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLE 2573

Query: 403  SEKPKTEIIKVDQSHSEDNTYQSLVEQLDQERE----------KRWRAEQAENKLMDYID 452
             +  ++E    D   S  N  Q   + L +E E          ++  A Q E  L  Y  
Sbjct: 2574 EKLKESEEANEDLRRSF-NALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA 2632

Query: 453  ELHKHANEKEDIHSLALLTTDRLK-------EIIFRERNSKGQLEVMVHKLQNEIKKLTV 505
            +L     ++E++H L+ L +   K       E++  ++ +  ++  +  KL+ E+K L  
Sbjct: 2633 QLKV---KEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHH 2689

Query: 506  ELMKAKDQQEDHLKHLRTLEKTLEKMERQ------KRQQQAAQI----RLIQEVELKASA 555
            +    +++ E   + +  L + L +ME++      + +   AQI    R +  ++     
Sbjct: 2690 DAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDH 2749

Query: 556  ADREIYLLRTSLHREREQAQQLHQLLALKEQ----EHRKELETREFFTDADFQDALAKEI 611
            A+ E+  L+      R+    L +L  LKEQ      R  L +   F+    ++     +
Sbjct: 2750 ANEELDELK------RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHL 2803

Query: 612  AKEEK----KHEQMI------KEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGF 661
             K  +    K EQ++      ++   ++   S+    L+NE R  L  E  +F+  ++G 
Sbjct: 2804 EKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE-RDHLWNELEKFRKSEEGK 2862

Query: 662  ENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQI 721
            +  A + + S   +   Q  +   SSL  D   ++KE K    +  ++ QE       ++
Sbjct: 2863 QRSAAQPSTSPAEV---QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT-----EL 2914

Query: 722  NTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQ---QGS 778
            + L+  +++ + K+   ++++ E                 LR E   W HEL Q   + S
Sbjct: 2915 HPLKAQLQEYQDKTKAFQIMQEE-----------------LRQENLSWQHELHQLRMEKS 2957

Query: 779  SLAQNRGKLEAQI--------ESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLK 830
            S   +  +++ Q         + LS     +R+   S S    +K +     +       
Sbjct: 2958 SWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASP 3017

Query: 831  DCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKE 890
            D  Q      + L+ ++ +  K    ++ +K  ++ ++     +  E K  L  QL    
Sbjct: 3018 DGSQNLVYETELLRTQLNDSLK----EIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTS 3073

Query: 891  VELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFE---NKEKKLKAERDKSIELQK 947
              L E ++ Y          G+LL H     K+V+E      N +    A ++K+   +K
Sbjct: 3074 QSLRENQQHY----------GDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRK 3123

Query: 948  NAMEKLHSMDDAFKRQVDAIVEAHQA--EIAQLANEKQKCIDSANLKVHQIEKEMRELLE 1005
            +  E+L     +F      +    Q   E+ +L  E++    +A   +   E+++R L  
Sbjct: 3124 SDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEH 3183

Query: 1006 ETCKNKKT 1013
                + +T
Sbjct: 3184 SEWDSSRT 3191



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 65/319 (20%), Positives = 138/319 (43%), Gaps = 41/319 (12%)

Query: 713  TAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHE 772
            T  ++Q ++   E L+ + K      ++++ + VQL  +  A       L+ ERK   ++
Sbjct: 46   TQEDVQERLAYAEQLVVELK------DIIRQKDVQLQQKDEA-------LQEERKAADNK 92

Query: 773  LAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDC 832
            + +           L   IE +  +   +  T     + L    K   ++   I K+K  
Sbjct: 93   IKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHK 152

Query: 833  LQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKE---KLKQQLKGK 889
            LQEK+E I  LQ ++T+ +    EQ  + S++++E +   ++  E++E    L+ QL   
Sbjct: 153  LQEKEELISTLQAQLTQAQ---AEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQT 209

Query: 890  EVE------LEEIRKAYSTLNRKWHD-------KGELLCHLETQVKEVKEKFENKEKKL- 935
            + E      + E    + T  R   D       + ++   ++ +++ ++ K E  E+ L 
Sbjct: 210  QAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLV 269

Query: 936  -KAERDKSIELQKNAMEKLHSMDDAFKRQVDA-------IVEAHQAEIAQLANEKQKCID 987
             +A+    ++ +  A E+ + +     +Q++A        VE  + E   L  + +  + 
Sbjct: 270  GRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVA 329

Query: 988  SANLKVHQIEKEMRELLEE 1006
               L  H +++EM  LLE+
Sbjct: 330  ERKLSFHNLQEEMHHLLEQ 348


>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 2 [Homo sapiens]
          Length = 1403

 Score =  100 bits (249), Expect = 7e-21
 Identities = 167/839 (19%), Positives = 337/839 (40%), Gaps = 114/839 (13%)

Query: 270  LTSFMSVCQSSEPEKNNHENDLQNEIKLQKL------------DDQILQLLNETSNSIDN 317
            L +  + C+S++ ++   +N+L +++   K             D+QI QL +   +    
Sbjct: 433  LEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKR 492

Query: 318  VLEKDPRPKR--------DTDITSESDYGNRK--ECNRKVPRRSKIPYDAKTIQTIKHHN 367
            + E + + K+           +TSE+  GN +  E  +   +  K+ Y+  + +  K  N
Sbjct: 493  MYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRN 552

Query: 368  --KNYNSFVSCNRKMKPPYLKE-LYVSSSLANCPMLQESEKPKTEIIKVDQSHSE----- 419
              K     V   ++ +   ++E   +   L+ C M  E EK   ++ +++    E     
Sbjct: 553  QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM--EREKKGRKVTEMEGQAKELSAKL 610

Query: 420  ---------DNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLAL- 469
                     +N   SL  +++++ +K    E+   K +  I +L +   E E++ +    
Sbjct: 611  ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR---ELENVKAKLAQ 667

Query: 470  -LTTDRLKEIIFRERNSKGQLEVMVHKL-------QNEIKKLTVELMKAKDQQEDHLKHL 521
             +  +  +++  R     G+L   + +L       Q EI+K+ ++    K+Q  +    +
Sbjct: 668  HVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEM 727

Query: 522  RTLEKTLEKMERQKRQQQAA---QIRLIQEVELKASAADREIYLLRTSLHREREQAQQLH 578
            +     L+  E  K+   A      R + +V  K +    E+  L        +   +L 
Sbjct: 728  KNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLE 787

Query: 579  QLLALKEQEHRKELETREFFTDADFQ-DALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYM 637
             +    E+  ++ +  +    +   Q   L K+  ++++K   +  E      ++S QY+
Sbjct: 788  TVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYV 847

Query: 638  DLENEFRIALTVEA------RRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKD 691
             ++    + +T+        R   DVK  FE++  E  K K      +R    + + IK 
Sbjct: 848  PVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA 907

Query: 692  LTCMVKEQKTKLAEVSKLKQ-------ETAANL---QNQINTLEILIEDDKQKSIQI-EL 740
                + E + K++ +S+  +       E  AN    Q +I TL   I+  K++   I E 
Sbjct: 908  EYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEC 967

Query: 741  LKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC 800
            +K +   ++S    +           K    EL  Q S   Q     E +++   +EN+ 
Sbjct: 968  IKVKYAPIVSFEECERKF--------KATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK 1019

Query: 801  LRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDE 860
            L+K   +    LR K  +I+   E  R L     E ++ +K L +K TE++   ++ ++E
Sbjct: 1020 LKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEE 1079

Query: 861  KSSQLDEVL----------------EKLERH-NERKEKLKQQLKGK----EVELEEIRKA 899
             + Q  E+L                E L++  N   E LK++LK      E E + + K 
Sbjct: 1080 NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1139

Query: 900  YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 959
            +  L  + +    L  HL     ++KE FE +   +KA   +  E  +N ME++  +   
Sbjct: 1140 HQLLENQKNSSVPLAEHL-----QIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSE 1194

Query: 960  FKRQVDAIVEAHQAEIAQLANEK------QKCIDSANLKVHQIEKEMRELLEETCKNKK 1012
             +    A+ +    E+  L+  K      +  I S N K+  + ++  E+ EE    KK
Sbjct: 1195 VQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKK 1253



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 137/714 (19%), Positives = 287/714 (40%), Gaps = 112/714 (15%)

Query: 411  IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALL 470
            + V     E    Q L  + +  +E+  + +Q +  L+D ++ L    NE+  +      
Sbjct: 271  VNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLES 330

Query: 471  TTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEK 530
              ++LK ++  +     +    +  L+N  K    + + +     +  + +   +  +  
Sbjct: 331  EREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYM 390

Query: 531  MERQ-------KRQQQAAQIRLIQEVELKASAA-------DREIYLLRTSLHREREQAQQ 576
             + Q          Q  + +R + E+ L +  +        +E+  +RT     ++   +
Sbjct: 391  ADSQCTSPGIPAHMQSRSMLRPL-ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLK 449

Query: 577  LHQLLALKEQEHRK-ELETREFFTDAD-----FQDALAKEIAKEEKKHEQMIKEYQEKID 630
            L   LA K  E +   LE      D+D      +DAL K++ K   + E  +K+ Q    
Sbjct: 450  LQNELAHKVAECKALALECERVKEDSDEQIKQLEDAL-KDVQKRMYESEGKVKQMQTHFL 508

Query: 631  VLSQQYMDLENEFRIALTVEAR-RFQDVKDGFENVATELAK-----SKHALIWAQRKEN- 683
             L +            LT E + + +D+K  +E  + E+ K      ++ +I  + K + 
Sbjct: 509  ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDE 568

Query: 684  -----ESSSLIKDLTCMVKEQKTKLAEVSKLKQET------------AANLQNQINTLEI 726
                 E+  L K+L+    E++ K  +V++++ +             A   +N  ++L  
Sbjct: 569  GKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSN 628

Query: 727  LIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTE--RKVWGHELAQQGSSLAQNR 784
             + +  +K +++E  +HEK   +SE+   +  +  ++ +  + V   E  Q  S L Q  
Sbjct: 629  EVNEKAKKLVEME-REHEK--SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKS 685

Query: 785  GKLEAQIESLSRENECLRKTNES---DSDALR--------------IKCKIIDDQTETIR 827
            G+L  +I  L+ +N+ L+K  E    D+  L+              +  K+ +D  ++  
Sbjct: 686  GELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHD 745

Query: 828  KLKDCLQEKDEHI-KRLQEKITEIEKCTQE--QLDEKSSQLDEVLEKLERHNERKEKLKQ 884
             + D L  K   + ++  EK  E+EK   E   L +  S+L+ V    E+H +    LK 
Sbjct: 746  AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKS 805

Query: 885  QLKGKEVELEEIRKAYSTLNRKWH----------------------------DKGELLCH 916
             +   + +L E++K       K H                               + L  
Sbjct: 806  NIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 865

Query: 917  LETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIA 976
               ++ +VK+KFE+  ++    +DK+  L++N    L +  +  K +  ++ E H+A+++
Sbjct: 866  TNRELLDVKKKFEDINQEFVKIKDKNEILKRN----LENTQNQIKAEYISLAE-HEAKMS 920

Query: 977  QLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 1030
             L+   +K  DS    +    K   E++        T+ A+IK     L+ IQ+
Sbjct: 921  SLSQSMRKVQDSNAEILANYRKGQEEIV--------TLHAEIKAQKKELDTIQE 966



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 101/517 (19%), Positives = 212/517 (41%), Gaps = 48/517 (9%)

Query: 405  KPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDI 464
            K   E++ V +   + N  Q  V+  D+    +   E  +N++      L +H  +   +
Sbjct: 865  KTNRELLDVKKKFEDIN--QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSL 922

Query: 465  HSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTV--ELMKAKDQQ----EDHL 518
                    D   EI+   R  + ++  +  +++ + K+L    E +K K       E+  
Sbjct: 923  SQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECE 982

Query: 519  KHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER---EQAQ 575
            +  +  EK L+    ++ Q+ +     +++ + +     +EI+ L+  L  +    E++ 
Sbjct: 983  RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1042

Query: 576  QLHQLLALKEQEHRKELE--TREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLS 633
            ++ + L+ K  E  K+L+  ++++    + ++ L +E AK+         E     ++L 
Sbjct: 1043 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS-------EILAVQNLLQ 1095

Query: 634  QQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLT 693
            +Q++ LE        VEA + + +    EN+  EL   +        KE ++ + +  L 
Sbjct: 1096 KQHVPLEQ-------VEALK-KSLNGTIENLKEELKSMQRCY----EKEQQTVTKLHQLL 1143

Query: 694  CMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELA 753
               K     LAE  ++K+     +     +L    E+ + K  ++  L+ E       L 
Sbjct: 1144 ENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALK 1203

Query: 754  AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALR 813
              E+      ++ K    +L  Q SSL +    L  + E +  E    +K   S  D   
Sbjct: 1204 KLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKE 1263

Query: 814  IKCKIID----DQTE-------TIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKS 862
            +    I+    DQ E       TI +L+  +QE  + I+    KITE+     E+L +  
Sbjct: 1264 LLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN-DVERLKQAL 1322

Query: 863  SQLDEVL----EKLERHNERKEKLKQQLKGKEVELEE 895
            + L ++        +R ++  + L+ Q+K  E +L +
Sbjct: 1323 NGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLAD 1359



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 75/382 (19%), Positives = 166/382 (43%), Gaps = 33/382 (8%)

Query: 284  KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEK--DPRPKRDTDITSESDYGNRK 341
            + +HE +     K  +L+ Q L+ L++    + NV EK  +   K+ ++I +  +   ++
Sbjct: 1039 EKSHEMERALSRKTDELNKQ-LKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQ 1097

Query: 342  ECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLK--ELYVSSSLANCPM 399
                 VP             TI++  +   S   C  K +    K  +L  +   ++ P+
Sbjct: 1098 H----VPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1153

Query: 400  -----LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDY-IDE 453
                 ++E+ + +  IIK      E+ + Q+ +E++ + + +    +QA  KL    + +
Sbjct: 1154 AEHLQIKEAFEKEVGIIKASLREKEEES-QNKMEEVSKLQSEVQNTKQALKKLETREVVD 1212

Query: 454  LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 513
            L K+   K D+ +      ++L  +    R  +   E ++H  + EI         AKD+
Sbjct: 1213 LSKYKATKSDLETQISSLNEKLANL---NRKYEEVCEEVLHAKKKEIS--------AKDE 1261

Query: 514  QEDHLKHLRTLEKTLEKMER-QKRQQQAAQI-RLIQEVELKASAADREIYLLRTSLHRER 571
            +E  L H    ++  ++ ER  K      ++ R IQE   +  A D +I  L   + R +
Sbjct: 1262 KE--LLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLK 1319

Query: 572  EQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDV 631
            +    L QL        +++ +  +  T      +L +++A  +++H+++I  Y+  +  
Sbjct: 1320 QALNGLSQLTYTSGNPTKRQSQLID--TLQHQVKSLEQQLADADRQHQEVIAIYRTHLLS 1377

Query: 632  LSQQYMDLENEFRIALTVEARR 653
             +Q +MD + +  +   ++ R+
Sbjct: 1378 AAQGHMDEDVQEALLQIIQMRQ 1399


>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
            repeats isoform 1 [Homo sapiens]
          Length = 1416

 Score =  100 bits (249), Expect = 7e-21
 Identities = 167/839 (19%), Positives = 337/839 (40%), Gaps = 114/839 (13%)

Query: 270  LTSFMSVCQSSEPEKNNHENDLQNEIKLQKL------------DDQILQLLNETSNSIDN 317
            L +  + C+S++ ++   +N+L +++   K             D+QI QL +   +    
Sbjct: 446  LEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKR 505

Query: 318  VLEKDPRPKR--------DTDITSESDYGNRK--ECNRKVPRRSKIPYDAKTIQTIKHHN 367
            + E + + K+           +TSE+  GN +  E  +   +  K+ Y+  + +  K  N
Sbjct: 506  MYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRN 565

Query: 368  --KNYNSFVSCNRKMKPPYLKE-LYVSSSLANCPMLQESEKPKTEIIKVDQSHSE----- 419
              K     V   ++ +   ++E   +   L+ C M  E EK   ++ +++    E     
Sbjct: 566  QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM--EREKKGRKVTEMEGQAKELSAKL 623

Query: 420  ---------DNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLAL- 469
                     +N   SL  +++++ +K    E+   K +  I +L +   E E++ +    
Sbjct: 624  ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR---ELENVKAKLAQ 680

Query: 470  -LTTDRLKEIIFRERNSKGQLEVMVHKL-------QNEIKKLTVELMKAKDQQEDHLKHL 521
             +  +  +++  R     G+L   + +L       Q EI+K+ ++    K+Q  +    +
Sbjct: 681  HVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEM 740

Query: 522  RTLEKTLEKMERQKRQQQAA---QIRLIQEVELKASAADREIYLLRTSLHREREQAQQLH 578
            +     L+  E  K+   A      R + +V  K +    E+  L        +   +L 
Sbjct: 741  KNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLE 800

Query: 579  QLLALKEQEHRKELETREFFTDADFQ-DALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYM 637
             +    E+  ++ +  +    +   Q   L K+  ++++K   +  E      ++S QY+
Sbjct: 801  TVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYV 860

Query: 638  DLENEFRIALTVEA------RRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKD 691
             ++    + +T+        R   DVK  FE++  E  K K      +R    + + IK 
Sbjct: 861  PVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA 920

Query: 692  LTCMVKEQKTKLAEVSKLKQ-------ETAANL---QNQINTLEILIEDDKQKSIQI-EL 740
                + E + K++ +S+  +       E  AN    Q +I TL   I+  K++   I E 
Sbjct: 921  EYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEC 980

Query: 741  LKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC 800
            +K +   ++S    +           K    EL  Q S   Q     E +++   +EN+ 
Sbjct: 981  IKVKYAPIVSFEECERKF--------KATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK 1032

Query: 801  LRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDE 860
            L+K   +    LR K  +I+   E  R L     E ++ +K L +K TE++   ++ ++E
Sbjct: 1033 LKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEE 1092

Query: 861  KSSQLDEVL----------------EKLERH-NERKEKLKQQLKGK----EVELEEIRKA 899
             + Q  E+L                E L++  N   E LK++LK      E E + + K 
Sbjct: 1093 NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1152

Query: 900  YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 959
            +  L  + +    L  HL     ++KE FE +   +KA   +  E  +N ME++  +   
Sbjct: 1153 HQLLENQKNSSVPLAEHL-----QIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSE 1207

Query: 960  FKRQVDAIVEAHQAEIAQLANEK------QKCIDSANLKVHQIEKEMRELLEETCKNKK 1012
             +    A+ +    E+  L+  K      +  I S N K+  + ++  E+ EE    KK
Sbjct: 1208 VQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKK 1266



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 137/714 (19%), Positives = 287/714 (40%), Gaps = 112/714 (15%)

Query: 411  IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALL 470
            + V     E    Q L  + +  +E+  + +Q +  L+D ++ L    NE+  +      
Sbjct: 284  VNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLES 343

Query: 471  TTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEK 530
              ++LK ++  +     +    +  L+N  K    + + +     +  + +   +  +  
Sbjct: 344  EREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYM 403

Query: 531  MERQ-------KRQQQAAQIRLIQEVELKASAA-------DREIYLLRTSLHREREQAQQ 576
             + Q          Q  + +R + E+ L +  +        +E+  +RT     ++   +
Sbjct: 404  ADSQCTSPGIPAHMQSRSMLRPL-ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLK 462

Query: 577  LHQLLALKEQEHRK-ELETREFFTDAD-----FQDALAKEIAKEEKKHEQMIKEYQEKID 630
            L   LA K  E +   LE      D+D      +DAL K++ K   + E  +K+ Q    
Sbjct: 463  LQNELAHKVAECKALALECERVKEDSDEQIKQLEDAL-KDVQKRMYESEGKVKQMQTHFL 521

Query: 631  VLSQQYMDLENEFRIALTVEAR-RFQDVKDGFENVATELAK-----SKHALIWAQRKEN- 683
             L +            LT E + + +D+K  +E  + E+ K      ++ +I  + K + 
Sbjct: 522  ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDE 581

Query: 684  -----ESSSLIKDLTCMVKEQKTKLAEVSKLKQET------------AANLQNQINTLEI 726
                 E+  L K+L+    E++ K  +V++++ +             A   +N  ++L  
Sbjct: 582  GKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSN 641

Query: 727  LIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTE--RKVWGHELAQQGSSLAQNR 784
             + +  +K +++E  +HEK   +SE+   +  +  ++ +  + V   E  Q  S L Q  
Sbjct: 642  EVNEKAKKLVEME-REHEK--SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKS 698

Query: 785  GKLEAQIESLSRENECLRKTNES---DSDALR--------------IKCKIIDDQTETIR 827
            G+L  +I  L+ +N+ L+K  E    D+  L+              +  K+ +D  ++  
Sbjct: 699  GELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHD 758

Query: 828  KLKDCLQEKDEHI-KRLQEKITEIEKCTQE--QLDEKSSQLDEVLEKLERHNERKEKLKQ 884
             + D L  K   + ++  EK  E+EK   E   L +  S+L+ V    E+H +    LK 
Sbjct: 759  AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKS 818

Query: 885  QLKGKEVELEEIRKAYSTLNRKWH----------------------------DKGELLCH 916
             +   + +L E++K       K H                               + L  
Sbjct: 819  NIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 878

Query: 917  LETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIA 976
               ++ +VK+KFE+  ++    +DK+  L++N    L +  +  K +  ++ E H+A+++
Sbjct: 879  TNRELLDVKKKFEDINQEFVKIKDKNEILKRN----LENTQNQIKAEYISLAE-HEAKMS 933

Query: 977  QLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 1030
             L+   +K  DS    +    K   E++        T+ A+IK     L+ IQ+
Sbjct: 934  SLSQSMRKVQDSNAEILANYRKGQEEIV--------TLHAEIKAQKKELDTIQE 979



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 101/517 (19%), Positives = 212/517 (41%), Gaps = 48/517 (9%)

Query: 405  KPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDI 464
            K   E++ V +   + N  Q  V+  D+    +   E  +N++      L +H  +   +
Sbjct: 878  KTNRELLDVKKKFEDIN--QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSL 935

Query: 465  HSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTV--ELMKAKDQQ----EDHL 518
                    D   EI+   R  + ++  +  +++ + K+L    E +K K       E+  
Sbjct: 936  SQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECE 995

Query: 519  KHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER---EQAQ 575
            +  +  EK L+    ++ Q+ +     +++ + +     +EI+ L+  L  +    E++ 
Sbjct: 996  RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1055

Query: 576  QLHQLLALKEQEHRKELE--TREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLS 633
            ++ + L+ K  E  K+L+  ++++    + ++ L +E AK+         E     ++L 
Sbjct: 1056 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS-------EILAVQNLLQ 1108

Query: 634  QQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLT 693
            +Q++ LE        VEA + + +    EN+  EL   +        KE ++ + +  L 
Sbjct: 1109 KQHVPLEQ-------VEALK-KSLNGTIENLKEELKSMQRCY----EKEQQTVTKLHQLL 1156

Query: 694  CMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELA 753
               K     LAE  ++K+     +     +L    E+ + K  ++  L+ E       L 
Sbjct: 1157 ENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALK 1216

Query: 754  AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALR 813
              E+      ++ K    +L  Q SSL +    L  + E +  E    +K   S  D   
Sbjct: 1217 KLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKE 1276

Query: 814  IKCKIID----DQTE-------TIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKS 862
            +    I+    DQ E       TI +L+  +QE  + I+    KITE+     E+L +  
Sbjct: 1277 LLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN-DVERLKQAL 1335

Query: 863  SQLDEVL----EKLERHNERKEKLKQQLKGKEVELEE 895
            + L ++        +R ++  + L+ Q+K  E +L +
Sbjct: 1336 NGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLAD 1372



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 75/382 (19%), Positives = 166/382 (43%), Gaps = 33/382 (8%)

Query: 284  KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEK--DPRPKRDTDITSESDYGNRK 341
            + +HE +     K  +L+ Q L+ L++    + NV EK  +   K+ ++I +  +   ++
Sbjct: 1052 EKSHEMERALSRKTDELNKQ-LKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQ 1110

Query: 342  ECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLK--ELYVSSSLANCPM 399
                 VP             TI++  +   S   C  K +    K  +L  +   ++ P+
Sbjct: 1111 H----VPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1166

Query: 400  -----LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDY-IDE 453
                 ++E+ + +  IIK      E+ + Q+ +E++ + + +    +QA  KL    + +
Sbjct: 1167 AEHLQIKEAFEKEVGIIKASLREKEEES-QNKMEEVSKLQSEVQNTKQALKKLETREVVD 1225

Query: 454  LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 513
            L K+   K D+ +      ++L  +    R  +   E ++H  + EI         AKD+
Sbjct: 1226 LSKYKATKSDLETQISSLNEKLANL---NRKYEEVCEEVLHAKKKEIS--------AKDE 1274

Query: 514  QEDHLKHLRTLEKTLEKMER-QKRQQQAAQI-RLIQEVELKASAADREIYLLRTSLHRER 571
            +E  L H    ++  ++ ER  K      ++ R IQE   +  A D +I  L   + R +
Sbjct: 1275 KE--LLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLK 1332

Query: 572  EQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDV 631
            +    L QL        +++ +  +  T      +L +++A  +++H+++I  Y+  +  
Sbjct: 1333 QALNGLSQLTYTSGNPTKRQSQLID--TLQHQVKSLEQQLADADRQHQEVIAIYRTHLLS 1390

Query: 632  LSQQYMDLENEFRIALTVEARR 653
             +Q +MD + +  +   ++ R+
Sbjct: 1391 AAQGHMDEDVQEALLQIIQMRQ 1412


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  100 bits (249), Expect = 7e-21
 Identities = 160/813 (19%), Positives = 332/813 (40%), Gaps = 125/813 (15%)

Query: 292  QNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRS 351
            ++E K ++L+++++ LL E  N +   ++ +     D +          + C++ +  + 
Sbjct: 871  KSEAKRKELEEKMVTLLKE-KNDLQLQVQAEAEGLADAE----------ERCDQLIKTKI 919

Query: 352  KIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEII 411
            ++    K +       +  N+ ++  ++       EL            ++ +  +  + 
Sbjct: 920  QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK-----------KDIDDLELTLA 968

Query: 412  KVD-QSHSEDNTYQSLVEQ---LDQEREKRWRAEQA-ENKLMDYIDELHKHANEKEDIHS 466
            KV+ + H+ +N  ++L E+   LD+   K  + ++A +      +D+L    ++   +  
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028

Query: 467  LALLT---TDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRT 523
              +      D L+  + +E+  +  LE    KL+ ++K     +M  +++++   + L+ 
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088

Query: 524  LEKTLEKMERQKRQQQAAQIRL---IQEVELKASAADREIYLLRTSLHREREQAQQLHQL 580
             E  +  ++ +   +QA  I+L   I+E++ +    + EI   R S  +  +Q   L + 
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1148

Query: 581  L---------------ALKEQEHRKELETREFFTDADFQDALAKEI--AKEEKKHEQMIK 623
            L               A  E   ++E E ++   D + +  L  E   A   KKH   + 
Sbjct: 1149 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE-EATLQHEATAATLRKKHADSVA 1207

Query: 624  EYQEKIDVLSQQYMDLE---NEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQR 680
            E  E+ID L +    LE   +E ++ +   A   + V     N+       +  L   + 
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267

Query: 681  KENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIEL 740
            KE E   LI DLT      +T+  E S+   E  A +         L    +  + QIE 
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ-------LSRGKQAFTQQIEE 1320

Query: 741  LKHEKVQLISELAAKESLIFGLRTERKVWGHE---LAQQGSSLAQNRGKLEAQIESLSRE 797
            LK    QL  E+ AK +L   L++ R    H+   L +Q     +++ +L+  +   + E
Sbjct: 1321 LKR---QLEEEIKAKNALAHALQSSR----HDCDLLREQYEEEQESKAELQRALSKANTE 1373

Query: 798  NECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQE- 856
                R   E+D+       +  ++  E  +KL   LQ  +EH++ +  K   +EK  Q  
Sbjct: 1374 VAQWRTKYETDA------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL 1427

Query: 857  -------------------QLDEKSSQLDEVL----EKLERHNERKEKLKQQLKGKEVEL 893
                                LD+K    D++L    +K E  +   E  +++ +    EL
Sbjct: 1428 QNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL 1487

Query: 894  EEIRKAYS-------TLNRKWHDKGELLCHLETQVKE----------VKEKFENKEKKLK 936
             +I+ AY        TL R+  +  + +  L  Q+ E          +K++ E ++ +L+
Sbjct: 1488 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ 1547

Query: 937  A---ERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 993
            A   E + S+E ++  + ++    +  K +VD  +     EI QL     + ++S     
Sbjct: 1548 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ--- 1604

Query: 994  HQIEKEMRELLEETCKNKKTMEAKIKQLAFALN 1026
              ++ E+R    +  + KK ME  + ++   LN
Sbjct: 1605 STLDAEIRS-RNDAIRLKKKMEGDLNEMEIQLN 1636



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 122/553 (22%), Positives = 252/553 (45%), Gaps = 47/553 (8%)

Query: 497  QNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA 556
            + E+  +  E  K KD+        + LE   EKM    +++   Q+++  E E  A A 
Sbjct: 852  EKEMATMKEEFQKIKDELAKSEAKRKELE---EKMVTLLKEKNDLQLQVQAEAEGLADAE 908

Query: 557  DREIYLLRTSLHRER------EQAQQLHQLLA-LKEQEHRKELETREFFTDADFQDALAK 609
            +R   L++T +  E       E+A+   ++ A L  ++ + E E  E   D D  +    
Sbjct: 909  ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968

Query: 610  EIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELA 669
            ++ KE+   E  +K   E++  L +    L  E +       +   D++   + V T L 
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT-LT 1027

Query: 670  KSKHALIWAQRKENESSSLI--KDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEIL 727
            K+K  L   Q+ ++   SL   K L   ++  K KL    KL QE+  +++N+   L+  
Sbjct: 1028 KAKIKL--EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD-- 1083

Query: 728  IEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWG-----HELAQQGSSLAQ 782
             E  K+K  +I  L+       S++  +++L  G++ ++K+        EL ++  +   
Sbjct: 1084 -EKLKKKEFEISNLQ-------SKIEDEQAL--GIQLQKKIKELQARIEELEEEIEAERA 1133

Query: 783  NRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKR 842
            +R K E Q   LSRE E + +  E    A   + ++   +    +K++  L+E       
Sbjct: 1134 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT----- 1188

Query: 843  LQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYST 902
            LQ + T      +++  +  ++L E ++ L+R  ++ EK K ++K   +E++++     T
Sbjct: 1189 LQHEATAAT--LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK---MEIDDLASNVET 1243

Query: 903  LNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMD--DAF 960
            +++   +  ++   LE Q+ E+K K E +++ +     +   LQ  + E    +D  +A 
Sbjct: 1244 VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEAL 1303

Query: 961  KRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMR--ELLEETCKNKKTMEAKI 1018
              Q+    +A   +I +L  + ++ I + N   H ++      +LL E  + ++  +A++
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363

Query: 1019 KQ-LAFALNEIQQ 1030
            ++ L+ A  E+ Q
Sbjct: 1364 QRALSKANTEVAQ 1376



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 134/633 (21%), Positives = 262/633 (41%), Gaps = 111/633 (17%)

Query: 389  YVSSSLANCPMLQESEKPKTEIIKVDQSHSE---------DNTYQSL---VEQLDQEREK 436
            Y + ++     L+E++K   + ++  + H E         + T Q L   VE L  + E+
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440

Query: 437  RWRAEQAENKLMDYIDELHKHANEK-EDIHSLALLTTDRLKEI---IFRERNSKGQLEVM 492
               A  A +K     D++     +K E+ H+    +    + +   +F+ +N+  +    
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500

Query: 493  VHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELK 552
            +  L+ E K L  E+    +Q  +  K +  LEK  +++E++K + QAA    ++E E  
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA----LEEAE-- 1554

Query: 553  ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIA 612
            AS    E  +LR  L           +L  +K +  RK                      
Sbjct: 1555 ASLEHEEGKILRIQL-----------ELNQVKSEVDRK---------------------- 1581

Query: 613  KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK 672
                     I E  E+ID L + ++ +    +  L  E R   D     + +  +L + +
Sbjct: 1582 ---------IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632

Query: 673  HALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQ---ETAANLQNQINTLEILIE 729
              L  A R   E+    ++   ++K+ +  L +  + ++   E  A ++ + N L+  IE
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIE 1692

Query: 730  DDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEA 789
            + +    Q E  +    Q + + + +  L              L  Q +SL   + KLE 
Sbjct: 1693 ELRATLEQTERSRKIAEQELLDASERVQL--------------LHTQNTSLINTKKKLET 1738

Query: 790  QIESLSRENE-CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKIT 848
             I  +  E E  L++   ++  A     K I D      +LK   Q+   H++R+++ + 
Sbjct: 1739 DISQMQGEMEDILQEARNAEEKAK----KAITDAAMMAEELKK-EQDTSAHLERMKKNME 1793

Query: 849  EIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWH 908
            +  K  Q +LDE + QL   L+  ++  ++ E   ++L+G EVE E+ R A +    + H
Sbjct: 1794 QTVKDLQLRLDE-AEQL--ALKGGKKQIQKLEARVRELEG-EVESEQKRNAEAVKGLRKH 1849

Query: 909  DKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIV 968
                     E +VKE+  + E   K +       + LQ + ++KL +   ++KRQ +   
Sbjct: 1850 ---------ERRVKELTYQTEEDRKNI-------LRLQ-DLVDKLQAKVKSYKRQAEEAE 1892

Query: 969  EAHQAEIA---QLANEKQKCIDSANLKVHQIEK 998
            E     +A   +L +E ++  + A++   Q+ K
Sbjct: 1893 EQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  100 bits (249), Expect = 7e-21
 Identities = 160/813 (19%), Positives = 332/813 (40%), Gaps = 125/813 (15%)

Query: 292  QNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRS 351
            ++E K ++L+++++ LL E  N +   ++ +     D +          + C++ +  + 
Sbjct: 871  KSEAKRKELEEKMVTLLKE-KNDLQLQVQAEAEGLADAE----------ERCDQLIKTKI 919

Query: 352  KIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEII 411
            ++    K +       +  N+ ++  ++       EL            ++ +  +  + 
Sbjct: 920  QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK-----------KDIDDLELTLA 968

Query: 412  KVD-QSHSEDNTYQSLVEQ---LDQEREKRWRAEQA-ENKLMDYIDELHKHANEKEDIHS 466
            KV+ + H+ +N  ++L E+   LD+   K  + ++A +      +D+L    ++   +  
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028

Query: 467  LALLT---TDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRT 523
              +      D L+  + +E+  +  LE    KL+ ++K     +M  +++++   + L+ 
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088

Query: 524  LEKTLEKMERQKRQQQAAQIRL---IQEVELKASAADREIYLLRTSLHREREQAQQLHQL 580
             E  +  ++ +   +QA  I+L   I+E++ +    + EI   R S  +  +Q   L + 
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1148

Query: 581  L---------------ALKEQEHRKELETREFFTDADFQDALAKEI--AKEEKKHEQMIK 623
            L               A  E   ++E E ++   D + +  L  E   A   KKH   + 
Sbjct: 1149 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE-EATLQHEATAATLRKKHADSVA 1207

Query: 624  EYQEKIDVLSQQYMDLE---NEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQR 680
            E  E+ID L +    LE   +E ++ +   A   + V     N+       +  L   + 
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267

Query: 681  KENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIEL 740
            KE E   LI DLT      +T+  E S+   E  A +         L    +  + QIE 
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ-------LSRGKQAFTQQIEE 1320

Query: 741  LKHEKVQLISELAAKESLIFGLRTERKVWGHE---LAQQGSSLAQNRGKLEAQIESLSRE 797
            LK    QL  E+ AK +L   L++ R    H+   L +Q     +++ +L+  +   + E
Sbjct: 1321 LKR---QLEEEIKAKNALAHALQSSR----HDCDLLREQYEEEQESKAELQRALSKANTE 1373

Query: 798  NECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQE- 856
                R   E+D+       +  ++  E  +KL   LQ  +EH++ +  K   +EK  Q  
Sbjct: 1374 VAQWRTKYETDA------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL 1427

Query: 857  -------------------QLDEKSSQLDEVL----EKLERHNERKEKLKQQLKGKEVEL 893
                                LD+K    D++L    +K E  +   E  +++ +    EL
Sbjct: 1428 QNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL 1487

Query: 894  EEIRKAYS-------TLNRKWHDKGELLCHLETQVKE----------VKEKFENKEKKLK 936
             +I+ AY        TL R+  +  + +  L  Q+ E          +K++ E ++ +L+
Sbjct: 1488 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ 1547

Query: 937  A---ERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 993
            A   E + S+E ++  + ++    +  K +VD  +     EI QL     + ++S     
Sbjct: 1548 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ--- 1604

Query: 994  HQIEKEMRELLEETCKNKKTMEAKIKQLAFALN 1026
              ++ E+R    +  + KK ME  + ++   LN
Sbjct: 1605 STLDAEIRS-RNDAIRLKKKMEGDLNEMEIQLN 1636



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 122/553 (22%), Positives = 252/553 (45%), Gaps = 47/553 (8%)

Query: 497  QNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA 556
            + E+  +  E  K KD+        + LE   EKM    +++   Q+++  E E  A A 
Sbjct: 852  EKEMATMKEEFQKIKDELAKSEAKRKELE---EKMVTLLKEKNDLQLQVQAEAEGLADAE 908

Query: 557  DREIYLLRTSLHRER------EQAQQLHQLLA-LKEQEHRKELETREFFTDADFQDALAK 609
            +R   L++T +  E       E+A+   ++ A L  ++ + E E  E   D D  +    
Sbjct: 909  ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968

Query: 610  EIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELA 669
            ++ KE+   E  +K   E++  L +    L  E +       +   D++   + V T L 
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT-LT 1027

Query: 670  KSKHALIWAQRKENESSSLI--KDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEIL 727
            K+K  L   Q+ ++   SL   K L   ++  K KL    KL QE+  +++N+   L+  
Sbjct: 1028 KAKIKL--EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD-- 1083

Query: 728  IEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWG-----HELAQQGSSLAQ 782
             E  K+K  +I  L+       S++  +++L  G++ ++K+        EL ++  +   
Sbjct: 1084 -EKLKKKEFEISNLQ-------SKIEDEQAL--GIQLQKKIKELQARIEELEEEIEAERA 1133

Query: 783  NRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKR 842
            +R K E Q   LSRE E + +  E    A   + ++   +    +K++  L+E       
Sbjct: 1134 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT----- 1188

Query: 843  LQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYST 902
            LQ + T      +++  +  ++L E ++ L+R  ++ EK K ++K   +E++++     T
Sbjct: 1189 LQHEATAAT--LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK---MEIDDLASNVET 1243

Query: 903  LNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMD--DAF 960
            +++   +  ++   LE Q+ E+K K E +++ +     +   LQ  + E    +D  +A 
Sbjct: 1244 VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEAL 1303

Query: 961  KRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMR--ELLEETCKNKKTMEAKI 1018
              Q+    +A   +I +L  + ++ I + N   H ++      +LL E  + ++  +A++
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363

Query: 1019 KQ-LAFALNEIQQ 1030
            ++ L+ A  E+ Q
Sbjct: 1364 QRALSKANTEVAQ 1376



 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 134/633 (21%), Positives = 262/633 (41%), Gaps = 111/633 (17%)

Query: 389  YVSSSLANCPMLQESEKPKTEIIKVDQSHSE---------DNTYQSL---VEQLDQEREK 436
            Y + ++     L+E++K   + ++  + H E         + T Q L   VE L  + E+
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440

Query: 437  RWRAEQAENKLMDYIDELHKHANEK-EDIHSLALLTTDRLKEI---IFRERNSKGQLEVM 492
               A  A +K     D++     +K E+ H+    +    + +   +F+ +N+  +    
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500

Query: 493  VHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELK 552
            +  L+ E K L  E+    +Q  +  K +  LEK  +++E++K + QAA    ++E E  
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA----LEEAE-- 1554

Query: 553  ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIA 612
            AS    E  +LR  L           +L  +K +  RK                      
Sbjct: 1555 ASLEHEEGKILRIQL-----------ELNQVKSEVDRK---------------------- 1581

Query: 613  KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK 672
                     I E  E+ID L + ++ +    +  L  E R   D     + +  +L + +
Sbjct: 1582 ---------IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632

Query: 673  HALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQ---ETAANLQNQINTLEILIE 729
              L  A R   E+    ++   ++K+ +  L +  + ++   E  A ++ + N L+  IE
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIE 1692

Query: 730  DDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEA 789
            + +    Q E  +    Q + + + +  L              L  Q +SL   + KLE 
Sbjct: 1693 ELRATLEQTERSRKIAEQELLDASERVQL--------------LHTQNTSLINTKKKLET 1738

Query: 790  QIESLSRENE-CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKIT 848
             I  +  E E  L++   ++  A     K I D      +LK   Q+   H++R+++ + 
Sbjct: 1739 DISQMQGEMEDILQEARNAEEKAK----KAITDAAMMAEELKK-EQDTSAHLERMKKNME 1793

Query: 849  EIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWH 908
            +  K  Q +LDE + QL   L+  ++  ++ E   ++L+G EVE E+ R A +    + H
Sbjct: 1794 QTVKDLQLRLDE-AEQL--ALKGGKKQIQKLEARVRELEG-EVESEQKRNAEAVKGLRKH 1849

Query: 909  DKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIV 968
                     E +VKE+  + E   K +       + LQ + ++KL +   ++KRQ +   
Sbjct: 1850 ---------ERRVKELTYQTEEDRKNI-------LRLQ-DLVDKLQAKVKSYKRQAEEAE 1892

Query: 969  EAHQAEIA---QLANEKQKCIDSANLKVHQIEK 998
            E     +A   +L +E ++  + A++   Q+ K
Sbjct: 1893 EQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score =  100 bits (248), Expect = 9e-21
 Identities = 119/546 (21%), Positives = 248/546 (45%), Gaps = 88/546 (16%)

Query: 433 EREKRWRAEQAENKLMD-YIDELHKHANEKEDIHSLAL----LTTDRLKEIIFRERNSKG 487
           E E+   A   + K  D YI+EL K    + D  SL L    +T + LKE   + +    
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTK----ERDALSLELYRNTITDEELKEKNAKLQEKLQ 231

Query: 488 QLEVMVHKLQNEIKKLTVELMKAK--------DQQEDHL-KHLRTLEKTLE--------- 529
            +E    ++Q  +K+L  +L +AK          + DHL K L+++   L+         
Sbjct: 232 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291

Query: 530 -KMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEH 588
            ++ +Q+ ++   Q   IQE E K    + +I      +  + E+ ++  +++  KE++ 
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351

Query: 589 RKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALT 648
           R+             Q+ +  E  ++ ++ E+M+ E +EKI  L ++  + E        
Sbjct: 352 RR-------------QEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQE-------- 390

Query: 649 VEARRFQDVKDGFENVAT-ELAKSKHALIWAQRKE-NESSSLIKDLTCMVKEQKTKLAEV 706
            + R  ++ +   E +   E  + + A +W Q ++  E    I++    +  Q+ K+ E 
Sbjct: 391 -KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 449

Query: 707 SKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTER 766
            K+++E     Q ++   E  I + ++   Q E + HE+ ++  +             E 
Sbjct: 450 EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKM-HEQEKIRKQ-------------EE 495

Query: 767 KVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETI 826
           KVW     +Q   +     K+  Q E + R+ E +R+  E            I +Q E I
Sbjct: 496 KVW-----RQEEKMHDQEEKIREQEEKMWRQEEKIREQEEK-----------IREQEEKI 539

Query: 827 RKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQL 886
           R+ ++ +QE++E +   +EK+ E EK  +++ ++   Q +++ E+ E+  E++EK+ +Q 
Sbjct: 540 REQEEMMQEQEEKMGEQEEKMQEQEKMRRQE-EKIREQEEKIREQKEKIREQEEKIWEQ- 597

Query: 887 KGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQ 946
              E ++ E  +       K  ++ E +C  E +++E +EK   +E+K+  E++  +  Q
Sbjct: 598 ---EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM-WEQEVRLRQQ 653

Query: 947 KNAMEK 952
           +  M++
Sbjct: 654 EEKMQE 659



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 125/580 (21%), Positives = 256/580 (44%), Gaps = 94/580 (16%)

Query: 455  HKHANEKE---DIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAK 511
            H+ A  +E    +H++ +LT              K +L++ ++  Q+ +K+L  E     
Sbjct: 117  HQEALRRELEAQVHTIRILTCQ------------KTELQMALYYSQHAVKQLEGEARDLI 164

Query: 512  DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER 571
             +  D  K    LE+ L  +  QK++      R I+E+  +  A   E+Y    +    +
Sbjct: 165  SRLHDSWKFAGELEQALSAVATQKKKAD----RYIEELTKERDALSLELYRNTITDEELK 220

Query: 572  EQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDV 631
            E+  +L + L L E E + E++               KE+ ++ ++ + ++ + Q     
Sbjct: 221  EKNAKLQEKLQLVESE-KSEIQLN------------VKELKRKLERAKLLLPQQQ----- 262

Query: 632  LSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKD 691
            L  +   L  E +   +V A+    V++    +   L + +   +W Q ++      I++
Sbjct: 263  LQAEADHLGKELQ---SVSAKLQAQVEEN--ELWNRLNQQQEEKMWRQEEK------IQE 311

Query: 692  LTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELL--KHEKVQLI 749
                ++EQ+ K+ E  +  +E    ++ Q    E++ E +++   Q E++  K EK++ +
Sbjct: 312  WEEKIQEQEEKIREQEEKIREQEEKMRRQE---EMMWEKEEKMRRQEEMMWEKEEKMRRL 368

Query: 750  SELA-AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESD 808
             E+   KE  I  L  E K+   E  ++     Q   K+  Q +   +E +  R      
Sbjct: 369  EEMMWEKEEKIREL--EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR------ 420

Query: 809  SDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEV 868
                         Q E IR+ ++ ++E+++ + R +EKI E EK  +E   EK  + +E+
Sbjct: 421  -------------QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE---EKRQEQEEM 464

Query: 869  LEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNR---KWHDKGELLCHLETQVKEVK 925
              + E+  E++E  +Q  K K  E E+IRK    + R   K HD+ E +   E ++   +
Sbjct: 465  WRQEEKIREQEEIWRQ--KEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQE 522

Query: 926  EKFENKEKKLKAERDKSIELQKNAMEKLHSM---------DDAFKRQVDAIVEAHQ--AE 974
            EK   +E+K++ + +K  E ++   E+   M          +  +RQ + I E  +   E
Sbjct: 523  EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIRE 582

Query: 975  IAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTM 1014
              +   E+++ I     K+ + E+ M+E  E+  + ++ M
Sbjct: 583  QKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM 622



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 77/341 (22%), Positives = 164/341 (48%), Gaps = 28/341 (8%)

Query: 696  VKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAK 755
            +KE+  KL E  +L +   + +Q  +  L+  +E  K    Q + L+ E   L  EL + 
Sbjct: 219  LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ-QQLQAEADHLGKELQSV 277

Query: 756  ESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNES---DSDAL 812
             + +     E ++W     QQ   + +   K++   E +  + E +R+  E      + +
Sbjct: 278  SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337

Query: 813  RIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKL 872
            R + +++ ++ E +R+ ++ + EK+E ++RL+E + E E+  +E L+EK  + +++ E+ 
Sbjct: 338  RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRE-LEEKMHEQEKIREQE 396

Query: 873  ERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKE 932
            E+  E +EK+++Q K +E E +  R+                   E +++E +EK   +E
Sbjct: 397  EKRQE-EEKIREQEKRQEQEAKMWRQ-------------------EEKIREQEEKIREQE 436

Query: 933  KKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLK 992
            KK+  + +K  E +K   E+     +   RQ + I E  +    +    +Q+ I     K
Sbjct: 437  KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEK 496

Query: 993  VHQIEKEMRELLEETCKNKKTM---EAKIKQLAFALNEIQQ 1030
            V + E++M +  E+  + ++ M   E KI++    + E ++
Sbjct: 497  VWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEE 537



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 112/544 (20%), Positives = 240/544 (44%), Gaps = 79/544 (14%)

Query: 372 SFVSCNRKMKPPYLKELY-----VSSSLANCPMLQESEKPKTEII--KVDQSHSEDNTYQ 424
           S V+  +K    Y++EL      +S  L    +  E  K K   +  K+    SE +  Q
Sbjct: 182 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ 241

Query: 425 SLVEQLDQEREK----------RWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR 474
             V++L ++ E+          +  A+    +L     +L     E E  + L      +
Sbjct: 242 LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL----NQQ 297

Query: 475 LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ 534
            +E ++R+     + E    K+Q + +K+  +  K ++Q+E   K  R  E   EK E+ 
Sbjct: 298 QEEKMWRQEEKIQEWE---EKIQEQEEKIREQEEKIREQEE---KMRRQEEMMWEKEEKM 351

Query: 535 KRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELET 594
           +RQ++     ++ E E K    +  ++     +   RE  +++H+   ++EQE +++ E 
Sbjct: 352 RRQEE-----MMWEKEEKMRRLEEMMWEKEEKI---RELEEKMHEQEKIREQEEKRQEE- 402

Query: 595 REFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRF 654
                         ++I ++EK+ EQ  K ++++  +  Q+    E E ++    E    
Sbjct: 403 --------------EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 448

Query: 655 QDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLK--QE 712
           Q      E +  E  + +   +W Q ++      I         QK K+ E  K++  +E
Sbjct: 449 Q------EKIREEEKRQEQEEMWRQEEKIREQEEIW-------RQKEKMHEQEKIRKQEE 495

Query: 713 TAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHE 772
                + +++  E  I + ++K  + E    E+ + I E   K      +R + ++    
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEK------IREQEEM---- 545

Query: 773 LAQQGSSLAQNRGKLEAQIESLSRENECLRKTNES---DSDALRIKCKIIDDQTETIRKL 829
           + +Q   + +   K++ Q E + R+ E +R+  E      + +R + + I +Q E IR+ 
Sbjct: 546 MQEQEEKMGEQEEKMQEQ-EKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQ 604

Query: 830 KDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGK 889
           ++ +QE++E +   +EK+ E E+  QEQ ++   Q +++ E+  R  +++EK+++  +  
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664

Query: 890 EVEL 893
           E  +
Sbjct: 665 EAAI 668


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
            [Homo sapiens]
          Length = 899

 Score =  100 bits (248), Expect = 9e-21
 Identities = 127/615 (20%), Positives = 268/615 (43%), Gaps = 65/615 (10%)

Query: 400  LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQA-----------ENKLM 448
            L+E EK   E+ + ++   E    +   EQ+ ++ EK W  E+            E +L 
Sbjct: 323  LREQEK---ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379

Query: 449  DYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELM 508
            +   ++ +   +  D         +RL+E   R R  +   E  V K++ E KK+  +  
Sbjct: 380  EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE-QVEKMREE-KKMQEQEK 437

Query: 509  KAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLH 568
            K +DQ+E   +  R  E+  EK  R++ +    Q   +Q+ E      + + +       
Sbjct: 438  KTRDQEEKMQEEERIRER--EKKMREEEETMREQEEKMQKQEENMWEQEEKEW----QQQ 491

Query: 569  REREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQ--MIKEYQ 626
            R  EQ ++L +   ++EQE  K  E  E   D +      K++ ++EK  EQ   + E +
Sbjct: 492  RLPEQKEKLWEQEKMQEQEE-KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 550

Query: 627  EKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESS 686
            EK+    Q+  D E         + ++  D +        E  + +  +   ++K  E  
Sbjct: 551  EKMRDQEQKMWDQEERMEKKTQEQEKKTWDQE--------EKMREEERMREREKKMREEE 602

Query: 687  SLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKV 746
             ++++    ++EQ+ K+ E  +   E    +Q Q    E  + + ++K  + E    E+ 
Sbjct: 603  EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ----EEKMWEQEEKMWEQEEKMWEQQ 658

Query: 747  QLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNE 806
            +L  +             + K+W HE  Q+   + +   K+  Q +   +  E  +KT  
Sbjct: 659  RLPEQ-------------KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT-- 703

Query: 807  SDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLD 866
             D + +R        + E++R+ +  ++E++E ++  +EK+ E E+  QEQ +E   Q +
Sbjct: 704  WDQEKMR--------EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755

Query: 867  EVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKE 926
            ++ E+ E+  E++   +Q+ K  E E  + ++       K  D+ E +   E +++  +E
Sbjct: 756  KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815

Query: 927  KFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCI 986
            K   +E+K+  + +K         EK+   ++    Q + + E  Q +  ++  +++K +
Sbjct: 816  KMRGQEEKMWGQEEK----MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEK-M 870

Query: 987  DSANLKVHQIEKEMR 1001
                 K+ + E++MR
Sbjct: 871  RGQEEKMREQEEKMR 885



 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 163/798 (20%), Positives = 342/798 (42%), Gaps = 112/798 (14%)

Query: 278  QSSEPEKNNHEND--LQNEIKLQKLDDQILQLLNETSNSIDNVL---EKDPRPKRDTDIT 332
            Q  E +K +H++   L+ EI+ Q   D  +++L      ++  L   +   R   D ++ 
Sbjct: 78   QLKEEKKASHQHQEALRREIEAQ---DHTIRILTCQKTELETALYYSQDAARKFEDGNLG 134

Query: 333  SESDYGNR-KECNRKVP----RRSKIPYDAKTIQTIKHHNKNYN-------SFVSCNRKM 380
            + S +     +  R  P      S IP ++K +    HH+ ++        S VS   K 
Sbjct: 135  TPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKK 194

Query: 381  KPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRA 440
               Y++EL            +E +    E+ +         T + L ++  + +EK   A
Sbjct: 195  ADRYIEEL-----------TKERDALSLELYR------NTITNEELKKKNAELQEKLPLA 237

Query: 441  EQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEI 500
            E  ++++   + EL +     + +  L  + T+ L+E ++R+     + E  + K + ++
Sbjct: 238  ESEKSEIQLNVKELKRKLERAKFL--LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295

Query: 501  ----KKLTVELMKAKDQQED---HLKHLRTLEKTLEKMERQKRQQQ--AAQIRLIQEVEL 551
                ++L  +  K ++Q+E      K LR  EK L + E++ R+Q+    Q   +QE E 
Sbjct: 296  WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355

Query: 552  KASAADREIYLLRTSLHRERE-----QAQQLHQLLALKEQEHR---KELETREFFTDADF 603
            K    + ++      + R+ E     + Q   Q   +++QE R   ++   RE       
Sbjct: 356  KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE 415

Query: 604  QDALAKEIAK--EEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVK--D 659
            Q+ + +++ K  EEKK ++  K+ +++ + + ++    E E ++    E  R Q+ K   
Sbjct: 416  QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475

Query: 660  GFENVATELAK--------SKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKL-K 710
              EN+  +  K         +   +W Q K  E    I +    +++Q+    +  K+ +
Sbjct: 476  QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535

Query: 711  QETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWG 770
            QE     ++Q+   E  + D +QK    E    +K Q                 E+K W 
Sbjct: 536  QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ---------------EQEKKTWD 580

Query: 771  HELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLK 830
             E   +     + R K   + E + RE E   K  E +          + +Q E + + +
Sbjct: 581  QEEKMREEERMREREKKMREEEEMMREQE--EKMQEQEEK--------MQEQEEKMWEQE 630

Query: 831  DCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKE 890
            + +QE++E +   +EK+ E E+   EQ      +L E  EKL  H + +E+ K Q + ++
Sbjct: 631  EKMQEQEEKMWEQEEKMWEQEEKMWEQ-----QRLPEQKEKLWEHEKMQEQEKMQEQEEK 685

Query: 891  V-ELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNA 949
            + E E++ K      +K  D+ ++    E  ++E ++K   +E+ ++ + +K  E +   
Sbjct: 686  IWEQEKMEKKTQEQEKKTWDQEKM--REEESMREREKKMREEEEMMREQEEKMQEQE--- 740

Query: 950  MEKLHSMDDAFKRQVDAIVEAHQA--EIAQLANEKQKCIDSANL----KVHQIEKEMREL 1003
             EK+   ++    Q + + E  +   E  +L  +K+K  +   +    K+ + E++MR+ 
Sbjct: 741  -EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ 799

Query: 1004 LEETCKNKKTMEAKIKQL 1021
             E+    ++ M  + +++
Sbjct: 800  EEKMRGQEEKMRGQEEKM 817



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 89/462 (19%), Positives = 200/462 (43%), Gaps = 39/462 (8%)

Query: 568  HREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQE 627
            H   +  Q   QL   K+  H+ +   R    + + QD   + +  ++ + E  +   Q+
Sbjct: 67   HSPEDTQQNRAQLKEEKKASHQHQEALRR---EIEAQDHTIRILTCQKTELETALYYSQD 123

Query: 628  KIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSS 687
                     +   + F +AL+   + F+    G  + +    +SK          + +  
Sbjct: 124  AARKFEDGNLGTPSSFNLALS---QAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE 180

Query: 688  LIKDLTCMVKEQKTKLAEVSKL-KQETAANLQNQINTLEILIEDDKQKSIQIE----LLK 742
            L + L+ +    K     + +L K+  A +L+   NT  I  E+ K+K+ +++    L +
Sbjct: 181  LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNT--ITNEELKKKNAELQEKLPLAE 238

Query: 743  HEKVQL---ISELAAK-ESLIFGL-RTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRE 797
             EK ++   + EL  K E   F L + +      E+ +Q   L +   K+  Q E + R+
Sbjct: 239  SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 298

Query: 798  NECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQ 857
             E LR+               + +Q E + + +  L+E+++ ++  ++++ E     Q++
Sbjct: 299  EERLREQEGK-----------MREQEEKMWRQEKRLREQEKELREQEKELRE-----QKE 342

Query: 858  LDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHL 917
            L E+  Q+ E  EK+    E+  + ++++  +E  L E  K      +K  D+ E +   
Sbjct: 343  LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 402

Query: 918  ETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQ 977
            + +++E +E+   +E K+  + +K  E +K   ++  + D   K Q +  +   + ++  
Sbjct: 403  DERLREKEERMREQE-KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM-- 459

Query: 978  LANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIK 1019
               E+++ +     K+ + E+ M E  E+  + ++  E K K
Sbjct: 460  --REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 499


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 155/708 (21%), Positives = 303/708 (42%), Gaps = 102/708 (14%)

Query: 400  LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHAN 459
            L+E E+   ++++     +E    Q+  E   +  E R R    + +L + + +L     
Sbjct: 875  LEEMERKHQQLLEEKNILAEQ--LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVE 932

Query: 460  EKEDIHSLALLTTDR-------LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKD 512
            E+E+ + +      +       L+E +  E  ++ +L++     + +IKK+  E++  +D
Sbjct: 933  EEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLED 992

Query: 513  QQEDHLKHLRTLEKTLEKM-----ERQKRQQQAAQIRLIQEVEL--------KASAADRE 559
            Q    +K  + +E  + +      E +++ +  A+IR  QEV +        K     +E
Sbjct: 993  QNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE 1052

Query: 560  IYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHE 619
            +   +  L  E    Q     L  +  E + +L  +E     + Q ALA+    +E  H+
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE----EELQGALAR--GDDETLHK 1106

Query: 620  ----QMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHAL 675
                ++++E Q +I  L +   D E+E       E ++ +D+ +  E + TEL  +    
Sbjct: 1107 NNALKVVRELQAQIAELQE---DFESEKASRNKAEKQK-RDLSEELEALKTELEDTLDTT 1162

Query: 676  IWAQ----RKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEI----- 726
               Q    ++E E + L K L    +E K   A++  ++Q  A  L+     LE      
Sbjct: 1163 AAQQELRTKREQEVAELKKALE---EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK 1219

Query: 727  ---------LIEDDKQKSIQIELLKHEKVQL----------ISELAAKESLIFGLRTERK 767
                     L  D+K+ + ++++L+  K +           + EL AK S    LR E  
Sbjct: 1220 ANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE-- 1277

Query: 768  VWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTET-- 825
                 LA++ S L      +   +E   ++     K   S    L+   +++ ++T    
Sbjct: 1278 -----LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL 1332

Query: 826  -----IRKL---KDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNE 877
                 IR+L   K+ LQE+ E  +  ++ + +     Q QL +   ++D+ L  +E   E
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392

Query: 878  RKEKLKQQLKGKEVELEEIRKAY----STLNRKWHDKGELLCHLETQVKEVKEKFENKEK 933
             K+KL +  +     LEE   AY     T NR   +  +L   L+ Q ++V    E K+K
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ-RQVASNLEKKQK 1451

Query: 934  K---LKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANE------KQK 984
            K   L AE +KSI   + A E+  +  +A +++  A+  A   E A  A E      KQ 
Sbjct: 1452 KFDQLLAE-EKSIS-ARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQL 1509

Query: 985  CIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 1032
              D  +L     + ++ + + E  K+K+ +E +++++   L E++ ++
Sbjct: 1510 RADMEDLM--SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 122/575 (21%), Positives = 251/575 (43%), Gaps = 104/575 (18%)

Query: 491  VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKR---QQQAAQIRLIQ 547
            + V + + E++    EL+K K++Q      L  +E+  +++  +K    +Q  A+  L  
Sbjct: 845  LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904

Query: 548  EVE---LKASAADREIYLLRTSLHREREQAQQLHQLLA---LKEQEHRKELETREFFTDA 601
            E E    + +A  +E+  +   L    E+ ++ +Q+L     K Q H ++LE +      
Sbjct: 905  EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ-----L 959

Query: 602  DFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGF 661
            D ++   +++  E+   E  IK+ +E+I +L  Q      E ++           ++D  
Sbjct: 960  DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL-----------MEDRI 1008

Query: 662  ENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AANLQ 718
               +++LA+ +       +  N+   +I DL   +K+++    E+ K K++      +LQ
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068

Query: 719  NQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIF----GLRTERKVWGH--E 772
            +QI  L+  I++     ++++L K E+ +L   LA  +         L+  R++     E
Sbjct: 1069 DQIAELQAQIDE-----LKLQLAKKEE-ELQGALARGDDETLHKNNALKVVRELQAQIAE 1122

Query: 773  LAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDC 832
            L +   S   +R K E Q   LS E E L+   E   D    + ++   + + + +LK  
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182

Query: 833  LQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVE 892
            L+E+ ++           E   Q+     ++ L+E+ E+LE+    K  L++  +G E  
Sbjct: 1183 LEEETKN----------HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET- 1231

Query: 893  LEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 952
                            D  EL C ++  +++VK + E+K KKL A+           +++
Sbjct: 1232 ----------------DNKELACEVKV-LQQVKAESEHKRKKLDAQ-----------VQE 1263

Query: 953  LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEK-------------- 998
            LH+      R         + E+A+ A++ Q  +D+ +  + + EK              
Sbjct: 1264 LHAKVSEGDRL--------RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315

Query: 999  ---EMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 1030
               + +ELL+E  + K  + ++I+QL    N +Q+
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 139/647 (21%), Positives = 285/647 (44%), Gaps = 83/647 (12%)

Query: 398  PMLQESEKPKTEIIKVDQSHSEDNTYQSLVE-QLDQEREKRWRAEQAENKLMDYIDELHK 456
            P+LQ + + + E+   D+   +    Q+ VE +L++   K  +  + +N L + +    +
Sbjct: 843  PLLQVTRQEE-ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901

Query: 457  HANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQED 516
               E E++ +        L+EI+    +   + E     LQNE KK+             
Sbjct: 902  LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA----------- 950

Query: 517  HLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQ 576
               H++ LE+ L++ E  +++ Q  ++      E K    + EI LL     +  ++ + 
Sbjct: 951  ---HIQDLEEQLDEEEGARQKLQLEKV----TAEAKIKKMEEEILLLEDQNSKFIKEKKL 1003

Query: 577  LHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQY 636
            +   +A    +  +E E              AK +AK   K E MI + +E++    +  
Sbjct: 1004 MEDRIAECSSQLAEEEEK-------------AKNLAKIRNKQEVMISDLEERLKKEEKTR 1050

Query: 637  MDLENEFRIALTVEARRFQD----VKDGFENVATELAKSKHALIWAQRKENESSSLIKDL 692
             +LE   R  L  E    QD    ++   + +  +LAK +  L  A  + ++ +    + 
Sbjct: 1051 QELEKAKR-KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNA 1109

Query: 693  TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISEL 752
              +V+E + ++AE+    QE   + +   N  E   +  +  S ++E LK E    +   
Sbjct: 1110 LKVVRELQAQIAEL----QEDFESEKASRNKAE---KQKRDLSEELEALKTELEDTLDTT 1162

Query: 753  AAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESL-SRENECLRKTNESDSDA 811
            AA++     LRT+R+    E+A+   +L +     EAQI+ +  R    L + +E    A
Sbjct: 1163 AAQQE----LRTKRE---QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQA 1215

Query: 812  LRIKCKIIDDQ--TETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVL 869
             R K  +  ++   ET  K   C       +K LQ+   E E         K  +LD  +
Sbjct: 1216 KRFKANLEKNKQGLETDNKELAC------EVKVLQQVKAESE--------HKRKKLDAQV 1261

Query: 870  EKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKG----ELLCHLETQVKEVK 925
            ++L       ++L+ +L  K  +L+      STL  +   KG    +    LE+Q+++ +
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321

Query: 926  E--KFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQ 983
            E  + E ++K   + R + +E +KN++++    ++  ++ ++  V A Q   +QLA+ K+
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ---SQLADTKK 1378

Query: 984  KCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 1030
            K  D     +  +E+  ++LL    K+ + +  ++++ A A +++++
Sbjct: 1379 KVDDDLG-TIESLEEAKKKLL----KDAEALSQRLEEKALAYDKLEK 1420



 Score = 87.0 bits (214), Expect = 8e-17
 Identities = 148/723 (20%), Positives = 304/723 (42%), Gaps = 103/723 (14%)

Query: 357  AKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQS 416
            A+  + ++   KN+ + +   R+     L+EL           L+++++ K  + K  Q 
Sbjct: 1177 AELKKALEEETKNHEAQIQDMRQRHATALEEL--------SEQLEQAKRFKANLEKNKQG 1228

Query: 417  HSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLK 476
               DN  + L  ++   ++ +  +E    KL   + ELH   +E + +         +L+
Sbjct: 1229 LETDN--KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286

Query: 477  E------IIFRERNSKG-QLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK-HLRTLEKTL 528
                    +  E   KG +       L+++++  T EL++ + +Q+ +L   +R LE+  
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQD-TQELLQEETRQKLNLSSRIRQLEEEK 1345

Query: 529  EKMERQKRQQQAAQIRLIQEV-ELKASAADRE---------IYLLRTSLHREREQAQQLH 578
              ++ Q+ +++ A+  L ++V  L++  AD +         I  L  +  +  + A+ L 
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405

Query: 579  QLLA--------LKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE------ 624
            Q L         L++ ++R + E  +   D D Q  +A  + K++KK +Q++ E      
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465

Query: 625  -YQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQ---- 679
             Y E+ D    +  + E +  ++L        + K+ FE    +L      L+ ++    
Sbjct: 1466 RYAEERDRAEAEAREKETK-ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524

Query: 680  RKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETA-ANLQNQINTLEILIEDDKQKSIQI 738
            +  +E     + L   V+E +T+L E+    Q T  A L+ ++N   +  + ++    + 
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRD 1584

Query: 739  ELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSREN 798
            E  + +K  LI ++   E+    L  ERK     +A +   +  +   LEAQIE+ ++  
Sbjct: 1585 EQNEEKKRLLIKQVRELEA---ELEDERKQRALAVASK-KKMEIDLKDLEAQIEAANKAR 1640

Query: 799  E----CLRKTNESDSDALR-------IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKI 847
            +     LRK      D  R        + +I     E+ +KLK    E    I +LQE++
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE----ILQLQEEL 1696

Query: 848  TEIEKCTQEQLDEKSSQLDEVLEKLERHN---ERKEKLKQQLKGKEVELEEIRKAYSTLN 904
               E+  +    E+    DE+       +   + K +L+ ++   E ELEE +     LN
Sbjct: 1697 ASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1756

Query: 905  RKWHDKGELLCHLETQV---KEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFK 961
             ++      +  L  ++   +   +K +N  ++L+ +        K    KL  ++ A K
Sbjct: 1757 DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQN-------KELKAKLQELEGAVK 1809

Query: 962  RQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEM-RELLEETCKNK--KTMEAKI 1018
             +  A + A +A+I QL                  E+++ +E  E    NK  +  E K+
Sbjct: 1810 SKFKATISALEAKIGQL------------------EEQLEQEAKERAAANKLVRRTEKKL 1851

Query: 1019 KQL 1021
            K++
Sbjct: 1852 KEI 1854



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 133/676 (19%), Positives = 290/676 (42%), Gaps = 82/676 (12%)

Query: 273  FMSVCQSSEPEKNNHENDLQNEIKLQKLD-DQILQLLNETSNSIDNVLEKDPRPKRDTD- 330
            F     S E +  + +  LQ E + QKL+    ++ L E  NS+    E++   +++ + 
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETR-QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364

Query: 331  --ITSESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKEL 388
              +  +S   + K+         K+  D  TI++++   K                L + 
Sbjct: 1365 QVLALQSQLADTKK---------KVDDDLGTIESLEEAKKKLLKDAEA--------LSQR 1407

Query: 389  YVSSSLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLM 448
                +LA      + EK K  + +     + D  +Q  V    ++++K++    AE K +
Sbjct: 1408 LEEKALA----YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463

Query: 449  D--YIDELHKHANEKEDIHSLALLTTDRLKEIIFR----ERNSKGQLEVMVHKL---QNE 499
               Y +E  +   E  +  + AL     L+E +      ER +K QL   +  L   +++
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK-QLRADMEDLMSSKDD 1522

Query: 500  IKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADRE 559
            + K   EL K+K   E  ++ +RT    LE++E + +  + A++RL  EV ++A  A  E
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRT---QLEELEDELQATEDAKLRL--EVNMQAMKAQFE 1577

Query: 560  IYLLRTSLHREREQA---QQLHQLLALKEQEHRK-----------ELETREFFTDADFQD 605
              L       E ++    +Q+ +L A  E E ++           E++ ++     +  +
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN 1637

Query: 606  ALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVA 665
                E+ K+ +K +  +K+YQ +++          +E         ++ + ++     + 
Sbjct: 1638 KARDEVIKQLRKLQAQMKDYQRELEEARAS----RDEIFAQSKESEKKLKSLEAEILQLQ 1693

Query: 666  TELAKSKHALIWAQRKENESSSLIKDL----TCMVKEQKTKLAEVSKLKQETAANLQNQI 721
             ELA S+ A   A+++ +E +  I +     + ++ E++   A +++L++E    L+ + 
Sbjct: 1694 EELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE----LEEEQ 1749

Query: 722  NTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLA 781
            + +E+L +  ++ ++Q++ L        +ELAA+ S        R+    +  +  + L 
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLN-------AELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802

Query: 782  QNRG----KLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKD 837
            +  G    K +A I +L  +   L +  E ++       K++     T +KLK+   + +
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV---RRTEKKLKEIFMQVE 1859

Query: 838  EHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIR 897
            +  +   +   ++EK    ++ +   QL+E  E+  R N  + KL+++L       E + 
Sbjct: 1860 DERRHADQYKEQMEKANA-RMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918

Query: 898  KAYSTLNRKWHDKGEL 913
            +  STL  +    G +
Sbjct: 1919 REVSTLKNRLRRGGPI 1934


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 172/808 (21%), Positives = 340/808 (42%), Gaps = 148/808 (18%)

Query: 340  RKECNRKVPRRSKI---PYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLAN 396
            R E  + V RR  I    Y+ ++   +KH       ++    K+KP  LK       +A 
Sbjct: 799  RVEFQKMVQRRESIFCIQYNIRSFMNVKHW-----PWMKLFFKIKP-LLKSAETEKEMAT 852

Query: 397  CPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHK 456
              M +E +K K E+ K +    E    + LV  + ++ + + + +     L+D  +   +
Sbjct: 853  --MKEEFQKTKDELAKSEAKRKE--LEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQ 908

Query: 457  HANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLT-----VELMKAK 511
                K  + +     T+R ++    E     +L     KL++E  +L      +EL  AK
Sbjct: 909  LIKAKFQLEAKIKEVTERAED----EEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964

Query: 512  DQQEDHL---------KHLRTLEKTLEKMERQKRQQQAA--------------------- 541
             ++E H          + L  L++T+ K+ R+K+  Q A                     
Sbjct: 965  VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024

Query: 542  QIRLIQEVELKASAADREIYLLRTSLHREREQAQ---QLHQLLALKEQEHRKELETREFF 598
            + +L Q+VE   S+ ++E   LR  L R + + +   +L Q   L  +  +++L+ R   
Sbjct: 1025 KSKLEQQVEDLESSLEQE-KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER--L 1081

Query: 599  TDADFQDALAKEIAKEEK----KHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVE---- 650
               DF+    +   ++E+    + ++ IKE Q +I+ L ++ ++ E   R     +    
Sbjct: 1082 KKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE-IEAERATRAKTEKQRSDY 1140

Query: 651  ARRFQDVKD------GFENVATELAKSKHALIWAQRKENESSSLIKD--LTCMVKEQKTK 702
            AR  +++ +      G  +   EL K + A     R++ E ++L  +  +  + K+    
Sbjct: 1141 ARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADS 1200

Query: 703  LAEVS-----------KLKQETA--------------------ANLQNQINTLEILIEDD 731
            +AE+            KL++E +                    ANL+    TLE  + + 
Sbjct: 1201 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA 1260

Query: 732  KQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQG---SSLAQNRGKLE 788
            + K+ +I+       + +SEL  ++S    L+TE      +L ++    S L++++    
Sbjct: 1261 RGKNEEIQ-------RSLSELTTQKS---RLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310

Query: 789  AQIESLSRENECLRKTNESDSDAL---RIKCKIIDDQTETIRKLKDCLQE---------- 835
             Q E L R+ E   K   + + AL   R  C ++ +Q E  ++ K  LQ           
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370

Query: 836  ------KDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGK 889
                  + + I+R +E + E +K   ++L +   Q++ V  K     + K++L+ +++  
Sbjct: 1371 QWRTKYETDAIQRTEE-LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL 1429

Query: 890  EVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIEL--QK 947
             V++E      + L++K  +  ++L   +T+ +E + +    E  LK  R  S EL   K
Sbjct: 1430 MVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAEL---EASLKESRSLSTELFKLK 1486

Query: 948  NAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMREL---L 1004
            NA E+     +  KR+ +  +E   A++ +   E  K I        QIE E  ++   L
Sbjct: 1487 NAYEEALDQLETVKRE-NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLAL 1545

Query: 1005 EETCKNKKTMEAKIKQLAFALNEIQQDM 1032
            EE     +  EAKI ++   L +++ ++
Sbjct: 1546 EEAEAALEHEEAKILRIQLELTQVKSEI 1573



 Score = 97.1 bits (240), Expect = 8e-20
 Identities = 142/693 (20%), Positives = 296/693 (42%), Gaps = 107/693 (15%)

Query: 401  QESEKPKTEI-IKVDQSHSE-----------DNTYQSLVEQLDQEREKRWRAEQA----- 443
            Q+ EK K+E  +++D   S            +   ++L +QL + R K    +++     
Sbjct: 1216 QKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELT 1275

Query: 444  --ENKLMDYIDELHKHANEKEDIHSLALLT-------TDRLKEIIFRERNSKGQLEVMVH 494
              +++L     EL +   EKE I S    +       T+ LK  +  E  +K  L    H
Sbjct: 1276 TQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNAL---AH 1332

Query: 495  KLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVE-LKA 553
             LQ+      +   + +++QE   +  R L K   ++ + + + +   I+  +E+E  K 
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1392

Query: 554  SAADREIYLLRTSLHREREQAQQLHQLLA-LKEQEHRKELETREFFTDADFQDALAKEIA 612
              A R        L    EQ + ++   A L++ + R + E  +   D +  ++LA  + 
Sbjct: 1393 KLAQR--------LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD 1444

Query: 613  KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK 672
            K+++  ++++ E++ K +   +   +LE   + + ++    F+ +K+ +E    +L   K
Sbjct: 1445 KKQRNFDKVLAEWKTKCE---ESQAELEASLKESRSLSTELFK-LKNAYEEALDQLETVK 1500

Query: 673  HALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETA---ANLQNQINTLEILIE 729
                   R+       I DLT  + E    + E+ K +++     A++Q  +   E  +E
Sbjct: 1501 -------RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALE 1553

Query: 730  DDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEA 789
             ++ K ++I+L   E  Q+ SE+  K                 +A++   + Q +   + 
Sbjct: 1554 HEEAKILRIQL---ELTQVKSEIDRK-----------------IAEKDEEIEQLKRNYQR 1593

Query: 790  QIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITE 849
             +E++      L     S ++A+R+K K+  D  E   +L    ++  E +K L+    +
Sbjct: 1594 TVETMQ---SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQ 1650

Query: 850  IEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHD 909
            + K TQ  LD+     +++ E+L     R   L+ +++     LE+  +A     ++  D
Sbjct: 1651 L-KDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLD 1709

Query: 910  KGELLCHLETQ---VKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHS-------MDDA 959
              E +  L TQ   +   K+K E    +L++E + +    +NA EK          M + 
Sbjct: 1710 SNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEE 1769

Query: 960  FKRQVD--AIVEAHQAEIAQLANEKQKCIDSA--------NLKVHQIEKEMREL---LE- 1005
             K++ D  A +E  +  + Q   + Q  +D A          ++ ++E  +REL   LE 
Sbjct: 1770 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEG 1829

Query: 1006 ------ETCKNKKTMEAKIKQLAFALNEIQQDM 1032
                  E+ K  +  E ++K+L +   E ++++
Sbjct: 1830 EQKKNTESVKGLRKYERRVKELTYQSEEDRKNV 1862



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 161/874 (18%), Positives = 355/874 (40%), Gaps = 146/874 (16%)

Query: 225  DNLVSSDSPLNISEDEII-------DRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVC 277
            D L  S++     E++++       D    + A  + L+  E+       A       + 
Sbjct: 862  DELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIK 921

Query: 278  QSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSES-- 335
            + +E  ++  E + +   K +KL+D+  +L  +  + ++  L K  + K  T+   ++  
Sbjct: 922  EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD-LELTLAKVEKEKHATENKVKNLT 980

Query: 336  -DYGNRKECNRKVPRRSKIPYDA--KTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSS 392
             +     E   K+ R  K   +A  + +  ++      NS      K++   +++L   S
Sbjct: 981  EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQ-VEDL--ES 1037

Query: 393  SLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYID 452
            SL       E EK     ++ ++   E +   +    LD E +K+   E+ + K  +Y  
Sbjct: 1038 SL-------EQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQ 1090

Query: 453  ELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKD 512
               K     ED  +L L    ++KE           L+  + +L+ EI+       K + 
Sbjct: 1091 LQSK----VEDEQTLGLQFQKKIKE-----------LQARIEELEEEIEAERATRAKTEK 1135

Query: 513  QQEDHLKHLRTLEKTLEKME-------RQKRQQQAAQIRLIQEVELKASAADREIYLLRT 565
            Q+ D+ + L  L + LE+            ++++A  ++L +++E      +  +  LR 
Sbjct: 1136 QRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRK 1195

Query: 566  SLHRER--EQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIK 623
              H +   E  +Q+  L  +K+   + E E  EF  + D   +  + ++K +   E++ +
Sbjct: 1196 K-HADSVAELGEQIDNLQRVKQ---KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICR 1251

Query: 624  EYQEKIDVLSQQYMDLENEF------RIALTVEARRFQDVKDGFENVATELAKSKHALIW 677
              ++++     +  +++         +  L  EA       +  E++ ++L++SK A   
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAF-- 1309

Query: 678  AQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQ 737
                           T   +E K +L E +K K   A  LQ+  +  ++L E       Q
Sbjct: 1310 ---------------TQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE-------Q 1347

Query: 738  IELLKHEKVQLISELAAKESLIFGLRTERKVWG----HELAQQGSSLAQNRGKLEAQIES 793
             E  +  K +L   L+   S +   RT+ +        EL +    LAQ     E Q+E+
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407

Query: 794  LSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRL--------QE 845
            ++ +   L KT +     L+ + + +    E    L   L +K  +  ++        +E
Sbjct: 1408 VNAKCASLEKTKQR----LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEE 1463

Query: 846  KITEIEKCTQE------QLDEKSSQLDEVLEKLERHNERKEKLKQQLKG----------- 888
               E+E   +E      +L +  +  +E L++LE      + L+Q++             
Sbjct: 1464 SQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKT 1523

Query: 889  --------KEVELEE------IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKK 934
                    K++ELE+      + +A + L    H++ ++L  ++ ++ +VK + + K   
Sbjct: 1524 IHELEKSRKQIELEKADIQLALEEAEAALE---HEEAKIL-RIQLELTQVKSEIDRK--- 1576

Query: 935  LKAERDKSIE-LQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 993
              AE+D+ IE L++N    + +M  A   +V +     + E  +L  + +  ++   +++
Sbjct: 1577 -IAEKDEEIEQLKRNYQRTVETMQSALDAEVRS-----RNEAIRLKKKMEGDLNEIEIQL 1630

Query: 994  HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNE 1027
                ++      ET K+ ++++ ++K     L++
Sbjct: 1631 SHANRQ----AAETLKHLRSVQGQLKDTQLHLDD 1660



 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 112/512 (21%), Positives = 209/512 (40%), Gaps = 81/512 (15%)

Query: 400  LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHAN 459
            L+ES    TE+ K+       N Y+  ++QL+  + +    EQ    L + I E  K  +
Sbjct: 1472 LKESRSLSTELFKLK------NAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIH 1525

Query: 460  EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVEL---MKAKDQQED 516
            E E       L    ++  +     +    E  + ++Q E+ ++  E+   +  KD++ +
Sbjct: 1526 ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIE 1585

Query: 517  HLK--HLRTLEKTLEKMERQKRQQQAAQIRL-------IQEVELKASAADREIYLLRTSL 567
             LK  + RT+E     ++ + R +  A IRL       + E+E++ S A+R+     T  
Sbjct: 1586 QLKRNYQRTVETMQSALDAEVRSRNEA-IRLKKKMEGDLNEIEIQLSHANRQA--AETLK 1642

Query: 568  HREREQAQ----QLHQLLALKEQEHRKE----LETREFFTDADFQD--ALAKEIAKEEKK 617
            H    Q Q    QLH   AL+ QE  KE    +E R     A+ ++  A  ++  +  K 
Sbjct: 1643 HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKL 1702

Query: 618  HEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIW 677
             EQ + +  E++ +L  Q   L +  +   T   +   +V+D   +              
Sbjct: 1703 AEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRD-------------- 1748

Query: 678  AQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQ 737
            A+  E ++   I D   M +E K +        Q+T+A+L+     LE  ++D + +  +
Sbjct: 1749 ARNAEEKAKKAITDAAMMAEELKKE--------QDTSAHLERMKKNLEQTVKDLQHRLDE 1800

Query: 738  IE--LLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLS 795
             E   LK  K Q+         L F L  E+K        + +   +   K E +++ L+
Sbjct: 1801 AEQLALKGGKKQIQKLETRIRELEFELEGEQK--------KNTESVKGLRKYERRVKELT 1852

Query: 796  RENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQ 855
             ++E      E   + LR++             L D LQ K +  KR  E+  E      
Sbjct: 1853 YQSE------EDRKNVLRLQ------------DLVDKLQVKVKSYKRQAEEADEQANAHL 1894

Query: 856  EQLDEKSSQLDEVLEKLERHNERKEKLKQQLK 887
             +  +   +L+E  E+ +    +  KL+ + +
Sbjct: 1895 TKFRKAQHELEEAEERADIAESQVNKLRAKTR 1926



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 36/146 (24%), Positives = 67/146 (45%), Gaps = 14/146 (9%)

Query: 420  DNTYQSLVEQLDQEREKRWRAEQAE-NKLMDYIDELH--KHANEKEDIHSLALLTT--DR 474
            + T + L  +LD+  +   +  + +  KL   I EL       +K++  S+  L     R
Sbjct: 1788 EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERR 1847

Query: 475  LKEIIFR---ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKM 531
            +KE+ ++   +R +  +L+ +V KLQ ++K    +  +A +Q   HL   R  +  LE+ 
Sbjct: 1848 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEA 1907

Query: 532  ERQKRQQQAAQIRLIQEVELKASAAD 557
            E      + A I   Q  +L+A   D
Sbjct: 1908 E------ERADIAESQVNKLRAKTRD 1927


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 120/602 (19%), Positives = 268/602 (44%), Gaps = 53/602 (8%)

Query: 401 QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANE 460
           QE E  + E     Q   E    Q   E+L ++R++ W+  +      + +     H  E
Sbjct: 144 QERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQE-WQEREERRAEEEQLQSCKGHETE 202

Query: 461 K----EDIHSLALLTTDRL------------KEIIFRERNSKGQLEVMVHKLQNEIKKLT 504
           +    E +    LL   R             ++ +F+E   K +       L+ E +KL 
Sbjct: 203 EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEK-EWRKRETVLRKEEEKLQ 261

Query: 505 VELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLR 564
            E  + + + ++  + LR LE+   + ERQ+ +QQ  ++R  Q++  K     RE    R
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321

Query: 565 TSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE 624
                 REQ ++  +    +EQE R+E + R    +   +  L +E  +EE++ +Q+ +E
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE-QEEERREQQLRRE 380

Query: 625 YQEKIDVLSQQYMDLENEFRIALTVEARRFQDVK-----DGFENVATELAKSKHALIWAQ 679
            Q + +   ++   L  E ++    + RR Q ++        + +  E  + +H     Q
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440

Query: 680 RKENESSSLIKD--LTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQ 737
            +  +     ++     + +E++T+  E  + KQ+   + + +     + +E+++++  Q
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500

Query: 738 IELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRE 797
               +  + QL  E   +       R +R+     L Q+  S  Q R + E + E L + 
Sbjct: 501 ----ERREQQLRREQEERRE----QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552

Query: 798 NECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQE--KDEHIKRLQEKI--TEIEKC 853
            E   K  E +    R+K +  + + + +++ ++  Q+  K E  +RL++++   E+E+ 
Sbjct: 553 EE--EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610

Query: 854 TQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGEL 913
            QE+  E         ++L+R    +E+ +Q LK +E E     +    L R+  ++ E 
Sbjct: 611 EQEERRE---------QRLKREEPEEERRQQLLKSEEQE----ERRQQQLRREQQERREQ 657

Query: 914 LCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQA 973
               E + + ++++ + + ++ + E++ + E Q+ A E++ S    ++ Q+++  +A Q+
Sbjct: 658 RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717

Query: 974 EI 975
           ++
Sbjct: 718 KV 719



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 149/771 (19%), Positives = 307/771 (39%), Gaps = 109/771 (14%)

Query: 280  SEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGN 339
            SE ++   +  L+ E   Q+  +Q L+   E       +  +    +R+ ++  E     
Sbjct: 636  SEEQEERRQQQLRRE--QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA 693

Query: 340  RKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPM 399
            R+    ++P+           Q     +   +   S  RK +    ++            
Sbjct: 694  RERIKSRIPKWQW--------QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745

Query: 400  LQESEKPKTEIIKVDQSHSEDNTYQSLVEQ--------------LDQEREKRWRAEQAEN 445
            LQ  E+ +    + ++    D T+Q   E+              L ++RE++ RAE+ + 
Sbjct: 746  LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ 805

Query: 446  KLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTV 505
            +   ++ E  +    +           +R KE+ F E   + Q      +LQ E   L  
Sbjct: 806  REQRFLPEEEEKEQRRRQ-------RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858

Query: 506  ELMKAKDQ------------QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKA 553
            +  + + Q            +E+  +   TL       E+ +++QQ  Q    +E EL+ 
Sbjct: 859  DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ---EEEEELQR 915

Query: 554  SAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELE-TREFFTDADFQDALAKEIA 612
               ++     +   +RE EQ QQ  + L  +E+E R+  E  R++  D   Q    + + 
Sbjct: 916  EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975

Query: 613  K--EEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAK 670
            +  E+++ ++  K+Y+E+ + L Q+   L  E R     E RR Q+ +  +     EL +
Sbjct: 976  EEPEKRRRQEREKKYREE-EELQQEEEQLLREER-----EKRRRQEWERQYRK-KDELQQ 1028

Query: 671  SKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIED 730
             +  L+   R+E E   L        +E++ +  E  +L+QE    L  +  T       
Sbjct: 1029 EEEQLL---REEREKRRL--------QERERQYREEEELQQEEEQLLGEERET------- 1070

Query: 731  DKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQ 790
             +++ ++ +  K E++Q   E   +E      R ER+              +   +L+ +
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE-----------RQCREEEELQQE 1119

Query: 791  IESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEI 850
             E L RE    R+  E +                  R+ ++  QE+++ ++   EK    
Sbjct: 1120 EEQLLREEREKRRRQELE---------------RQYREEEEVQQEEEQLLREEPEKRRRQ 1164

Query: 851  EKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDK 910
            E   Q + +E+  Q +E L + E+   R+E+ +Q  + +E++ ++ ++ Y   +++   K
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224

Query: 911  GELLCHLETQVKEVK--------EKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKR 962
             +     E  V++ K        E+F   E     +R    +LQ + + +    D   +R
Sbjct: 1225 WQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ-HLLGEQQERDREQER 1283

Query: 963  QVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKT 1013
            +     + H  E  QL  E+QK     + K  + ++ +RE  EE  + ++T
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 154/789 (19%), Positives = 309/789 (39%), Gaps = 95/789 (12%)

Query: 288  ENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKV 347
            E   + E ++Q+ ++Q+L+   E        LE+  R   + ++  E +   R+E  ++ 
Sbjct: 1137 ERQYREEEEVQQEEEQLLR--EEPEKRRRQELERQYR--EEEELQQEEEQLLREEQEKRR 1192

Query: 348  PRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPK 407
              R +   + + +Q  K   +  +     + K +    KE  V  +   C   +  +  +
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252

Query: 408  TEIIKVDQSHSEDNTYQSLVEQLDQERE---KRW--------------RAEQAENKLMDY 450
             E  ++    S+ +    L EQ +++RE   +RW              R EQ E K  D 
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312

Query: 451  IDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQ-LEVMVHKLQNEIKKLTVELMK 509
              +  K    +E         TDR     FRE     Q  E    + Q   +K   E ++
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRK----FREEEQLLQEREEQPLRRQERDRKFREEELR 1368

Query: 510  AKDQ------QEDHLKHLRTLEKTLEKMER---QKRQQQAAQIR----LIQEVELKASAA 556
             ++Q      +E  L+      K L++ ++   Q+R+QQ  Q R      +E +L     
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428

Query: 557  DREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEK 616
            DR+       + R+  + + L +   L+++ HRK  E  +   + + Q    +E  ++  
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488

Query: 617  KHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHA-- 674
            + EQ ++  +       Q+    E E +     +    Q  +  F     +L + +    
Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548

Query: 675  -------------LIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQI 721
                          +  +R+E + S   +D    ++EQK +  E  +   E    L+ Q 
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608

Query: 722  NTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLA 781
               ++  E D++     +LL+  + Q   +L  +E     L  E ++   E  QQ   L 
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQ---QLHRQERDRKFLEEEPQLRRQEREQQ---LR 1662

Query: 782  QNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIK 841
             +R +   + E L +E E  +   +      R + + +  Q    R+ K   +E+    +
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQE---RERKFLQEEQQLRRQ 1719

Query: 842  RLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKE----------- 890
             L+ K  E E+  QE   E+  + +   + LE    R E+ +QQL+ +E           
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQL 1779

Query: 891  -VELEEIRKAYSTLNRKWHDKGELLCHLETQV------------KEVKEKFENKEKKLKA 937
              E EE +      +RK+ ++ +L    E Q             +E + + E +E++L+ 
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839

Query: 938  ERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIE 997
            ERD+    Q  A E+  + + + + +     E  Q E  +   E+++ +   +++  Q E
Sbjct: 1840 ERDR----QYRAEEQFATQEKSRREE----QELWQEEEQKRRQERERKLREEHIRRQQKE 1891

Query: 998  KEMRELLEE 1006
            ++    + E
Sbjct: 1892 EQRHRQVGE 1900



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 117/603 (19%), Positives = 267/603 (44%), Gaps = 59/603 (9%)

Query: 423  YQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRE 482
            Y +L +    + EKR R +  E+ L D   E  +   E  D          +L+E   + 
Sbjct: 86   YYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRD---------RQLEEEPGQR 136

Query: 483  RNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMER--QKRQQQA 540
            R  K Q E      + E +    E ++ +D+Q    +  R  ++  E+ ER  ++ Q Q+
Sbjct: 137  RRQKRQ-EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQS 195

Query: 541  AQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTD 600
             +    +E   +     RE+  LR     E++Q ++  Q    +E+E  KE   RE    
Sbjct: 196  CKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE-EKEWRKRETVLR 254

Query: 601  ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG 660
             +      +++ +EE + ++ ++E +E++  L +Q +  E +         RR Q ++  
Sbjct: 255  KE-----EEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309

Query: 661  FENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQ 720
             E    E  + +      +R+E +            +EQ+ +  +  + +Q+     + +
Sbjct: 310  QEEERREQQEERRE--QQERREQQEER---------REQQLRREQEERREQQLRREQEEE 358

Query: 721  INTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSL 780
                ++  E ++++  Q +L + ++++   +L  ++     LR E+++   +  ++   L
Sbjct: 359  RREQQLRREQEEERREQ-QLRREQQLRREQQLRREQQ----LRREQQLRREQQLRREQQL 413

Query: 781  AQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI 840
             + +     Q   L RE E   + +E   +  R + ++  +Q E     +D L+ ++E  
Sbjct: 414  RREQQLRREQ--QLRREQE--EERHEQKHEQERREQRLKREQEER----RDWLKREEETE 465

Query: 841  KRLQE-KITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 899
            +  QE +  ++++  +E+  E+  +L+E     E   E++E+ +QQL+ ++ E  E R  
Sbjct: 466  RHEQERRKQQLKRDQEEERRERWLKLEE-----EERREQQERREQQLRREQEERREQRL- 519

Query: 900  YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 959
                 ++  ++  L   L ++ +  +E+ E +E+ LK E +K +E ++         ++ 
Sbjct: 520  -----KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE- 573

Query: 960  FKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEK-EMRELLEETCKNKKTMEAKI 1018
              R+   +    +    +L  E+++ ++   LK  ++E+ E  E  E+  K ++  E + 
Sbjct: 574  --RRDQLLKREEERRQQRLKREQEERLEQ-RLKREEVERLEQEERREQRLKREEPEEERR 630

Query: 1019 KQL 1021
            +QL
Sbjct: 631  QQL 633



 Score = 74.3 bits (181), Expect = 5e-13
 Identities = 129/649 (19%), Positives = 276/649 (42%), Gaps = 77/649 (11%)

Query: 429  QLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQ 488
            Q DQER +R + ++ + K    ++E  K            L     L+E + +E+    +
Sbjct: 857  QEDQER-RRSQEQRRDQKWRWQLEEERKRRRH-------TLYAKPALQEQLRKEQQLLQE 908

Query: 489  LEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQE 548
             E  + + + E ++   +  + +++++   +  + L +  EK  RQ+R++Q  + + +Q+
Sbjct: 909  EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968

Query: 549  VE--LKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDA 606
             E  L     ++     R   +RE E+ QQ  + L  +E+E R+  E    +   D    
Sbjct: 969  KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028

Query: 607  LAKEIAKEEKKH---EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFEN 663
              +++ +EE++    ++  ++Y+E+ + L Q+   L  E R     E RR Q+++  +  
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREE-EELQQEEEQLLGEER-----ETRRRQELERQYRK 1082

Query: 664  VATELAKSKHALIWAQ-----RKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQ 718
               EL + +  L+  +     R+E E     ++     +EQ  +     + +QE     +
Sbjct: 1083 -EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 719  NQINTL---EILIEDDKQKSIQIEL---------LKHEKVQLISELAAKESLIFGLRTER 766
             +       E L+ ++ +K  + EL         L+ E+ QL+ E   K       R ER
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR------RQER 1195

Query: 767  KVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETI 826
            +    E  +      + R + E Q   L  + E  ++    D+   ++ CK    + E  
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDN---KVYCK--GRENEQF 1250

Query: 827  RKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVL---EKLERHNERKEKLK 883
            R+L+D      +  + LQ  + E ++  +EQ   +  Q D      E+LER  +++ K +
Sbjct: 1251 RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310

Query: 884  QQLKGKEVEL-----EEIRKAYSTLNRKWHDKGELLCHLETQV----------------- 921
             +   +E +L     EE R+   T +RK+ ++ +LL   E Q                  
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQET-DRKFREEEQLLQEREEQPLRRQERDRKFREEELRH 1369

Query: 922  KEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANE 981
            +E   KF  +E++L+ +  +   L++    +    +   ++  D      + ++++   E
Sbjct: 1370 QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR--QE 1427

Query: 982  KQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 1030
            + +       +V + E+E R+ LEE  + ++    K ++    L E ++
Sbjct: 1428 RDRKFREEEQQVRRQERE-RKFLEEEQQLRQERHRKFREEEQLLQEREE 1475



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 133/672 (19%), Positives = 284/672 (42%), Gaps = 91/672 (13%)

Query: 282  PEKNNHENDLQNEIKLQ-KLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNR 340
            PE+   E + Q E K + +   +  QLL E          ++ R +++TD     +    
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREE--------REEKRRRQETDRKFREEEQLL 1345

Query: 341  KECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPML 400
            +E   +  RR +   D K  +    H +    F+   ++++    +  +          L
Sbjct: 1346 QEREEQPLRRQE--RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKF----------L 1393

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLVEQLD-QEREKRWRAEQA-------ENKLMDYID 452
            +E ++ + +  +       D  ++   +QL  QER++++R E+        E K ++   
Sbjct: 1394 KEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453

Query: 453  EL----HKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELM 508
            +L    H+   E+E      LL     +++  +ER+ K   E    + Q   +K   + +
Sbjct: 1454 QLRQERHRKFREEEQ-----LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL 1508

Query: 509  KAKDQQEDHLKHLRTLEKTLEKMERQKR-QQQAAQIRLIQEVELKASAADREIYLLRTSL 567
            ++++ +   L+     E+ L + +RQ++  Q+  Q+R  +  + +    DR+ +     L
Sbjct: 1509 RSQEPERKFLEE----EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK-FREEEQL 1563

Query: 568  HREREQAQQLHQ----LLALKEQEHRKELETREFFTDA------DFQDALAKEIAKEEKK 617
             +ERE+ Q   Q       L+EQ+ R++ + R+F  D       + Q  L +E  ++ ++
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623

Query: 618  HEQMIKEYQEKIDVLSQQYMD---LENEFRIALTVEARRFQDVKDG-FENVATELAKSKH 673
             EQ+++E +E+   L +Q  D   LE E ++      ++ +  +D  F      L + + 
Sbjct: 1624 DEQLLQEREEQ--QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681

Query: 674  ALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQ 733
              +  Q ++ +     + L    +E+K    E    +QE     + +        E  +Q
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREE--------EQLRQ 1733

Query: 734  KSIQIELLKHEKVQLISELAA-----KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLE 788
            ++ Q +L + E+ + I E        +E  +     +RK    E  +Q     Q R +  
Sbjct: 1734 ETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ-- 1791

Query: 789  AQIESLSRENECLRKTNESDSDALRI-----KCKIIDDQTETIRKLKDCLQEKDEHIKRL 843
             + +   RE E LR+  E +   LR      K +  ++Q +   + +   QE+D   +  
Sbjct: 1792 -ESDRKFREEEQLRQ--EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR-- 1846

Query: 844  QEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQ-LKGKEVELEEIRKAYST 902
                 E +  TQE+   +  +L +  E+ +R  ER+ KL+++ ++ ++ E +  R+    
Sbjct: 1847 ----AEEQFATQEKSRREEQELWQE-EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEI 1901

Query: 903  LNRKWHDKGELL 914
             +++    G LL
Sbjct: 1902 KSQEGKGHGRLL 1913


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 143/690 (20%), Positives = 301/690 (43%), Gaps = 93/690 (13%)

Query: 391  SSSLANCPMLQESEKP----KTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENK 446
            SS +  C  +  + KP    + E   VD S+SE     S       E E   +  +    
Sbjct: 115  SSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE---- 170

Query: 447  LMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVE 506
                I+EL++   E    +      T+ L+++         + E  + +    I +LT  
Sbjct: 171  ----IEELNRELEEMRVTYG-----TEGLQQL--------QEFEAAIKQRDGIITQLTAN 213

Query: 507  LMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS 566
            L +A+ ++++ ++    L +  +K++ Q +Q QA++   ++     ++AAD    LL+  
Sbjct: 214  LQQARREKDETMREFLELTEQSQKLQIQFQQLQASET--LRNSTHSSTAAD----LLQAK 267

Query: 567  LHREREQAQQLHQLLALKEQEHRKELETREF-FTDADFQDALAKEIAKEEKKHEQMIKEY 625
                  Q Q   Q   L++ + +KE  T +  F     +    ++  K E  +++ I+E 
Sbjct: 268  QQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK 327

Query: 626  QEKIDVLSQQYMDLEN---EFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKE 682
            +  I+ L+ + ++ E    E +  LT   +   ++++       E+   K  L  +++KE
Sbjct: 328  ETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKE 387

Query: 683  NESSSLIKDLTCMVKEQKTKLAE--------VSKLKQETAANLQNQINTLEILIEDDKQK 734
             +SS  IK L   V+E + +  +        V +++QET   L+      ++  E D+  
Sbjct: 388  RQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLE------QLRAELDEMY 441

Query: 735  SIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESL 794
              QI  +K E ++    +A  E +    +T  K       +  S++  N  +++    ++
Sbjct: 442  GQQIVQMKQELIR--QHMAQMEEM----KTRHKGEMENALRSYSNITVNEDQIKLMNVAI 495

Query: 795  SRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKD---EHIKRLQEKITEIE 851
            +  N  L+ TN            I++++    R+L+D ++E     E I+R ++ I E E
Sbjct: 496  NELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE 555

Query: 852  KCTQEQLDEKSSQLD---EVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYST-LNRKW 907
                E     S+  D   E++   E   E + K + ++   +++LE + K  +  L+R  
Sbjct: 556  SKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA 615

Query: 908  HDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAI 967
              +   L  L TQ+      F ++E+  K + D  IE + N  +   ++   +K+Q+D +
Sbjct: 616  ESQEAELERLRTQLL-----FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGL 670

Query: 968  -------VEAHQ--------------AEIAQLANEKQKCIDSAN----LKVHQIEKEMRE 1002
                   +E  Q               EI++L + +Q  ++S +    L++++++KE+ E
Sbjct: 671  QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI-E 729

Query: 1003 LLEETCKNKKTMEAKIKQLAFALNEIQQDM 1032
            +L +  K K T+E ++++L      +++ M
Sbjct: 730  ILRQEEKEKGTLEQEVQELQLKTELLEKQM 759



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 137/663 (20%), Positives = 290/663 (43%), Gaps = 74/663 (11%)

Query: 401  QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANE 460
            Q+  + +  +++  Q   ED T Q       QE+ K +  EQ +       +E+ +    
Sbjct: 274  QQQLEEQDHLLEDYQKKKEDFTMQI---SFLQEKIKVYEMEQDKKVENSNKEEIQEKETI 330

Query: 461  KEDIHSLAL---LTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDH 517
             E++++  +     T  LK+ +       G+L+  + +   EIK + +EL  +K ++   
Sbjct: 331  IEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQS 390

Query: 518  LKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQL 577
             + ++ L  T+E+++++  +    +  ++Q +E       R++  LR  L  +    QQ+
Sbjct: 391  SEEIKQLMGTVEELQKRNHKDSQFETDIVQRME---QETQRKLEQLRAEL--DEMYGQQI 445

Query: 578  HQLLALKEQEHRKELETREFFTDADFQDALA--KEIAKEEKKHEQM---IKEYQEKIDVL 632
             Q+     ++H  ++E  +     + ++AL     I   E + + M   I E   K+   
Sbjct: 446  VQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT 505

Query: 633  SQQYMDLENEFRIALTVEA---RRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLI 689
            + Q   L+ E  + L  +    R+ +D+ +       ++ +++  +   + K NE+   +
Sbjct: 506  NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL 565

Query: 690  KDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLI 749
                  V++ K ++   S+ ++E     + ++   +          I++E+L+ EK  ++
Sbjct: 566  S----TVEDLKAEIVSASESRKELELKHEAEVTNYK----------IKLEMLEKEKNAVL 611

Query: 750  SELA-AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESD 808
              +A ++E+ +  LRT+  ++ HE         +   KL+  +E   R N  + K    D
Sbjct: 612  DRMAESQEAELERLRTQ-LLFSHE---------EELSKLKEDLEIEHRIN--IEKL--KD 657

Query: 809  SDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEV 868
            +  +  K +I   Q E  +K++    EKD  I +  + I EI K    Q    +S+ +E+
Sbjct: 658  NLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEM 717

Query: 869  LEKLERHNERKEKLKQQLKGK---EVELEEIRKAYSTLNR----KWHDKGELLCHLETQV 921
              ++    +  E L+Q+ K K   E E++E++     L +    K +D  E    LE + 
Sbjct: 718  TLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAEN 777

Query: 922  KEVKEKFENKEKKLKAERDKSIELQKNAME--KLHSMDDAFKRQVDAIVEAHQ---AEIA 976
              +K++ +  E  LK     S E +   ++  K  S D  ++++++ ++E ++    +  
Sbjct: 778  SILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCI 837

Query: 977  QLANEKQKCIDSANLKVHQIEKEMRELLE------------ETCKNKKTMEAKIKQLAFA 1024
            QL  E +K  ++ +      E   +EL E            E  KNK+ +E K K    A
Sbjct: 838  QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSK--LKA 895

Query: 1025 LNE 1027
            LNE
Sbjct: 896  LNE 898



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 149/718 (20%), Positives = 306/718 (42%), Gaps = 142/718 (19%)

Query: 413  VDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTT 472
            +D+ H  D  +Q  +++L+Q+ +   R +         +++L  H  EK D  S  LL+ 
Sbjct: 2074 IDREHERD-VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132

Query: 473  DRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKD--QQEDHLKHLRTLEKTLEK 530
            ++L+  I +ERN +      + KL+  +++L   L+ + D  Q+ +  KH   +E    K
Sbjct: 2133 EQLQRDI-QERNEE------IEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA---K 2182

Query: 531  MERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRK 590
             E     Q  A+   I   E + +  + ++   R  L  + E+ QQLH  L ++++E   
Sbjct: 2183 PELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2242

Query: 591  ELETRE-----FFTDADFQDALAKE---IAKEEK-----KHEQMIKEYQEKIDVLSQQYM 637
             L+  E     F  D +      KE   ++ +++     K  Q+I+E + +ID L++Q  
Sbjct: 2243 RLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2302

Query: 638  DLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVK 697
             L+ + +I                     ++ + K+ LI  +  E +   L+ D  C+ +
Sbjct: 2303 KLQQQLKITTD-----------------NKVIEEKNELI--RDLETQIECLMSDQECVKR 2343

Query: 698  EQKTKLAE----VSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISEL- 752
             ++ ++ +    + KL+QE A   Q        L E+      Q++++  EK+ L  ++ 
Sbjct: 2344 NREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVE 2403

Query: 753  AAKESLIF--GLRTERKVWGHELAQQGSSLAQNRGKLE-----------AQIESLSR--- 796
             A E + F   +  E     ++L Q+  SL + R  +E             I+ LS+   
Sbjct: 2404 TANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP 2463

Query: 797  --------------ENECLRKTNESDSDA--LRIKCKIID----------DQTETIRKLK 830
                          EN+   K+ E +     + ++ +++           + T+  +++K
Sbjct: 2464 ELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIK 2523

Query: 831  DCLQEKDEHIKRLQEKITEIEKCTQEQLDE---KSSQLDEVLE-------------KLER 874
            D  ++     + LQ+KI  ++K  +E++        QL+ V E             + ER
Sbjct: 2524 DMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPER 2583

Query: 875  HN-ERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 933
             N +   +L++   G ++    +R   S L  +  +    L   + QV+  ++    KEK
Sbjct: 2584 TNIQNLNQLREDELGSDISALTLR--ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2641

Query: 934  KL-----------KAERDK-------SIELQKNAMEKLHSMDDA-FKRQVDAIVEAHQAE 974
            KL           K +R+K        +E+ K   E  HS +++ F  +++A+     A 
Sbjct: 2642 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2701

Query: 975  IAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 1032
             A+LA+ K+        K  ++++E+  L++ET  N  +++  + Q+   L E ++ +
Sbjct: 2702 KAELASYKE--------KAEKLQEEL--LVKET--NMTSLQKDLSQVRDHLAEAKEKL 2747



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 153/709 (21%), Positives = 301/709 (42%), Gaps = 108/709 (15%)

Query: 400  LQESEKPKTEIIKVDQSHSEDNT-----YQSLVEQLDQEREKRWRA----EQAENKLMDY 450
            L+ ++  +TE+++      ++ T      + L E+L +E   R +      +AE  +  Y
Sbjct: 1868 LEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGY 1927

Query: 451  IDE---LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLT--V 505
             DE     +   EK DI        DRL++ +    N   +LE    ++Q E + L+   
Sbjct: 1928 ADEKTLFERQIQEKTDI-------IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980

Query: 506  ELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRT 565
            E MKA+    +  + L+  EK ++  E+ + Q QA ++R   + ++KA   D E  + R 
Sbjct: 1981 EAMKAEAGPVEQ-QLLQETEKLMK--EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF 2037

Query: 566  SLHREREQAQQLHQLLALKEQEHRKELETREFFTDADF------QDALAKEIAKEE---- 615
             +  E+E+  +L  L   + Q   K+LE    F D         +D   +EI K E    
Sbjct: 2038 -IELEQEKNTELMDLRQ-QNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095

Query: 616  -------------KKHEQMIKEYQEKIDVLSQQYMDLEN---------------EFRI-- 645
                         ++ EQ+    +EK D  S+  +  E                EFR+  
Sbjct: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155

Query: 646  ---ALTVEARRFQDVKDGFENVATELAKSKHALIWAQ-------RKENESSSLIKDLTCM 695
               AL V A  FQ V+D     A E        +  Q       RKE E ++L + L   
Sbjct: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF 2215

Query: 696  VKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAK 755
             +E + K  EV +L  +     +     L+ L +++K       L K +  +L   LA K
Sbjct: 2216 REELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK-------LFKDDMEKL--GLAIK 2266

Query: 756  ESLIFGLRTERKVWG------HELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDS 809
            ES     + +  ++G       E   +   L +   KL+ Q++ ++ +N+ + + NE   
Sbjct: 2267 ESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK-ITTDNKVIEEKNELIR 2325

Query: 810  DA-LRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEV 868
            D   +I+C ++ DQ    R  ++ +++ +E I++LQ+++  I + T       S + D +
Sbjct: 2326 DLETQIEC-LMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSL 2384

Query: 869  LEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQ---VKEVK 925
              +L+     K  L+QQ++    E+  ++      N K +   + L  L+ +   V++++
Sbjct: 2385 KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQ 2444

Query: 926  EKFENK-----EKKLKAERDKSIELQKNAMEKLHSMD--DAFKRQVDAIVEAHQAEIAQL 978
               EN      +   K + +  + L ++A++ L +     +F+      +   +  + QL
Sbjct: 2445 SIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQL 2504

Query: 979  ANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNE 1027
                +  + + +L++ Q  K+++++ E+     + ++ KI  L   + E
Sbjct: 2505 ----ESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEE 2549



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 158/774 (20%), Positives = 310/774 (40%), Gaps = 100/774 (12%)

Query: 210  TEINSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAV 269
            T+I   + + LE L D L ++D  L   +++I+ +   I     EL   +Q     S+ +
Sbjct: 336  TKIIEEEKKTLE-LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEI 394

Query: 270  LTSFMSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDT 329
                 +V    E +K NH++       +Q+++ +  + L +    +D +           
Sbjct: 395  KQLMGTV---EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM----------- 440

Query: 330  DITSESDYGNR-KECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVS-CNRKMKPPYLKE 387
                   YG +  +  +++ R+     +       +H  +  N+  S  N  +    +K 
Sbjct: 441  -------YGQQIVQMKQELIRQHMAQMEE---MKTRHKGEMENALRSYSNITVNEDQIKL 490

Query: 388  LYVSSSLANCPMLQ---ESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQA 443
            + V+ +  N  +     + EK K E+ + +++  +     + LVE+L   RE+  RA Q 
Sbjct: 491  MNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQT 550

Query: 444  ENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEI--K 501
              +    ++E HK  +  ED+ +  +  ++  KE+       K + EV  +K++ E+  K
Sbjct: 551  IAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL-----ELKHEAEVTNYKIKLEMLEK 605

Query: 502  KLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIY 561
            +    L +  + QE  L+ LRT                  Q+    E EL     D EI 
Sbjct: 606  EKNAVLDRMAESQEAELERLRT------------------QLLFSHEEELSKLKEDLEIE 647

Query: 562  LLRTSLHREREQA-----QQLHQLLALKEQEHRKELETREFFTD--ADFQDALAKEIAKE 614
              R ++ + ++       QQ+  L    + E  +++ET +F  D     Q+ L  EI+K 
Sbjct: 648  H-RINIEKLKDNLGIHYKQQIDGL----QNEMSQKIETMQFEKDNLITKQNQLILEISKL 702

Query: 615  EKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHA 674
            +   + ++    E++ +   Q  +L+ E  I      R+ +  K   E    EL + K  
Sbjct: 703  KDLQQSLVNSKSEEMTL---QINELQKEIEIL-----RQEEKEKGTLEQEVQEL-QLKTE 753

Query: 675  LIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK 734
            L+  Q KE E+    K       E +  + +  K   E    +   ++  E LI  D  K
Sbjct: 754  LLEKQMKEKENDLQEKFAQL---EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810

Query: 735  SIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESL 794
            S   + +  ++++++ E          L+ +      E+ +Q ++ +      E   + L
Sbjct: 811  SKSKDSVWEKEIEILIEENED------LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864

Query: 795  SRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCT 854
              E  CL K  +   D+          + E   KLK   +E   H++R+     +++   
Sbjct: 865  QEEYACLLKVKDDLEDSKN------KQELEYKSKLKALNEEL--HLQRINPTTVKMKSSV 916

Query: 855  QEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELL 914
                DE  + + E LE  E   +   +L ++L+  + E  E+ +  S L+ +   K   +
Sbjct: 917  ---FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI 973

Query: 915  CHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIV 968
              L    +EVK   + KE+     R+  I +  N  E + S D      +D +V
Sbjct: 974  SFLN---EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV 1024



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 97/451 (21%), Positives = 200/451 (44%), Gaps = 87/451 (19%)

Query: 522  RTLEKTLEKMERQKRQQQAAQIRLIQEVE-LKASAADREIYLLRTSLHREREQAQQLHQL 580
            R  E+ +E     +  Q+A +  L+ E++ L A    R+I     +L RE+E  +   +L
Sbjct: 3067 RIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKI-----TLKREQESEKPSQEL 3121

Query: 581  LALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLE 640
            L    Q+  K+ +  E   +       A E+ ++    + ++ E + +   L+Q  ++LE
Sbjct: 3122 LEYNIQQ--KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE---LAQTKLELE 3176

Query: 641  NEFRIA----LTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 696
               +        +EA R + VKD  + V        H L      E + S   ++L   +
Sbjct: 3177 TTLKAQHKHLKELEAFRLE-VKDKTDEV--------HLLNDTLASEQKKS---RELQWAL 3224

Query: 697  KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 756
            +++K KL    +  +E       ++  L+  +E  KQ+++Q+ LL  ++ QL++E   K 
Sbjct: 3225 EKEKAKLGRSEERDKE-------ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQK- 3276

Query: 757  SLIFGLRTERKVWGHELA-QQGSS------LAQNRGKLEAQIESLSRENECLRKTNESDS 809
                 + ++R ++  +L+ +QG +      L   + ++     +L RE E   +   SD 
Sbjct: 3277 -----IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331

Query: 810  DALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVL 869
                        Q+      +D L+E                   Q+QL+EK S++ E+L
Sbjct: 3332 TG----------QSRPPLPSEDLLKE------------------LQKQLEEKHSRIVELL 3363

Query: 870  EKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCH-LETQVKEVKEKF 928
             + E++     + +QQ+   E + +  RK   T  ++ + +G+   H L+++V++++ + 
Sbjct: 3364 NETEKYKLDSLQTRQQM---EKDRQVHRKTLQT-EQEANTEGQKKMHELQSKVEDLQRQL 3419

Query: 929  ENKEKK-----LKAERDKSI--ELQKNAMEK 952
            E K ++     L+ +R + I  E QK  +E+
Sbjct: 3420 EEKRQQVYKLDLEGQRLQGIMQEFQKQELER 3450



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 131/676 (19%), Positives = 271/676 (40%), Gaps = 95/676 (14%)

Query: 361  QTIKHHNKNYNSFVSCNRKM-KPPYLKELYVSSSLANCPML-----QESEKPKTEIIKVD 414
            Q I+     Y + + C +K  +   L E+    +  N   +     QESEKP  E++   
Sbjct: 3066 QRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELL--- 3122

Query: 415  QSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR 474
                E N  Q   + L+ + E         + + D   EL      +E + S  ++  + 
Sbjct: 3123 ----EYNIQQKQSQMLEMQVEL--------SSMKDRATEL------QEQLSSEKMVVAEL 3164

Query: 475  LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ 534
              E+      +K +LE  +      +K+L    ++ KD+ ++    +  L  TL   +++
Sbjct: 3165 KSEL----AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDE----VHLLNDTLASEQKK 3216

Query: 535  KRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQ---EHRKE 591
             R+ Q A  +   ++         E+  L+ SL  ++++  QL+ LL  ++Q   E +++
Sbjct: 3217 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQK 3276

Query: 592  LETREFFTDADFQDALAKEIAKEE--KKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTV 649
            +E++    DA   +   + +  +   +  +  I+E    +D   + +  L++      T 
Sbjct: 3277 IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG---TG 3333

Query: 650  EARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKL 709
            ++R     +D  + +  +L + KH+ I     E E   L   L    + +K +      L
Sbjct: 3334 QSRPPLPSEDLLKELQKQL-EEKHSRIVELLNETEKYKL-DSLQTRQQMEKDRQVHRKTL 3391

Query: 710  KQETAAN---------LQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIF 760
            + E  AN         LQ+++  L+  +E+ +Q+  +++L       ++ E   +E    
Sbjct: 3392 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451

Query: 761  GLRTERKVWGHELAQQGS-SLAQNRGK---LEAQIESLSRENECLRKTNESDSDALRIKC 816
              R  R++    L +  + SL  +R +   L+ +IE  ++E+   +    +        C
Sbjct: 3452 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT---GC 3508

Query: 817  KIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHN 876
               + + E IR+   C+  K + + +   +  + E    E        +DE++ +L    
Sbjct: 3509 ---NHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL---- 3561

Query: 877  ERKEKLKQQLKGKEVELEEIRKAYSTL-NRKWHDKGELLCHLETQVKEVKEKFENKEKKL 935
               +KL  Q +G+E  L     +  +L  R      EL  H+ +Q+ E K    N   KL
Sbjct: 3562 ---QKLTGQ-QGEEPSLVSPSTSCGSLTERLLRQNAELTGHI-SQLTEEKNDLRNMVMKL 3616

Query: 936  K----------AERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKC 985
            +          A RD S     N               ++AI+ + +    +     QK 
Sbjct: 3617 EEQIRWYRQTGAGRDNSSRFSLNG-----------GANIEAIIASEKEVWNREKLTLQKS 3665

Query: 986  IDSANLKVHQIEKEMR 1001
            +  A  +V++++ E+R
Sbjct: 3666 LKRAEAEVYKLKAELR 3681



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 139/649 (21%), Positives = 267/649 (41%), Gaps = 98/649 (15%)

Query: 428  EQLDQEREKRWRAEQAENKLMDYIDELHKHA-----NEKEDIHSLALLTTDRLKEIIFRE 482
            E+  +E+EK+ R+ Q    L    +  H +      NE E + + ++ T   L    ++E
Sbjct: 2654 EKKQREKEKK-RSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELAS--YKE 2710

Query: 483  RNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQ 542
            +  K Q E++V +           L K   Q  DHL   +     LEK E +   Q++ +
Sbjct: 2711 KAEKLQEELLVKETN------MTSLQKDLSQVRDHLAEAKEKLSILEK-EDETEVQESKK 2763

Query: 543  IRLIQE--VELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREF--- 597
              + +   ++L  S A +    L+ S   +  Q    +  + +  Q      E  E    
Sbjct: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQ 2823

Query: 598  FTDA--DFQDALAKEIAKEEKKH----EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEA 651
            FT+     Q+  A EI   E +H    E + +E+   + +L ++   L+   +   + E 
Sbjct: 2824 FTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEG 2883

Query: 652  RRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQ 711
                ++         E+  S     W Q      S    D+    + ++++ A  S  K+
Sbjct: 2884 SSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF-DIASEGRGEESESATDSFPKK 2942

Query: 712  -----ETAANLQNQINTL-EILIEDDKQKSIQ--IELLKHEKVQLISELAAKESLIFGLR 763
                     N   Q+ +L E    D +  SIQ   E    E+   I+ +++ + LI  ++
Sbjct: 2943 IKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQ 3002

Query: 764  TERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECL-------RKTNESDSDALRI-K 815
             +R+   ++ +Q   S +  RG+L   ++ +  E   +         T    +DA+ +  
Sbjct: 3003 LQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLN 3062

Query: 816  C--KIIDDQTETIRKLKDCLQEKDE----------HIKRLQEKIT-----EIEKCTQEQL 858
            C  + I +Q    +   +CLQ+ D           H +    KIT     E EK +QE L
Sbjct: 3063 CLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELL 3122

Query: 859  D----EKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELL 914
            +    +K SQ+ E+  +L    +R  +L++QL  +++ + E++   +        K EL 
Sbjct: 3123 EYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA------QTKLELE 3176

Query: 915  CHLETQVKEVKE----KFENKEK---------KLKAERDKSIELQ---KNAMEKLHSMDD 958
              L+ Q K +KE    + E K+K          L +E+ KS ELQ   +    KL   ++
Sbjct: 3177 TTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE 3236

Query: 959  AFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEET 1007
              K +++ +          L ++KQ+     NL+++ + ++ ++LL E+
Sbjct: 3237 RDKEELEDLK-------FSLESQKQR-----NLQLNLLLEQQKQLLNES 3273



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 144/750 (19%), Positives = 293/750 (39%), Gaps = 134/750 (17%)

Query: 218  QCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVC 277
            Q ++GL + +      +   +D +I +   +   I +L  L+Q              S+ 
Sbjct: 665  QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------------SLV 710

Query: 278  QSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDY 337
             S   E     N+LQ EI++ + +++    L +    +    E   +  ++ +   +  +
Sbjct: 711  NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKF 770

Query: 338  GNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPP-YLKELYVSSSLAN 396
               +  N  +    K   D   I T     +      S   K K   + KE+ +      
Sbjct: 771  AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI------ 824

Query: 397  CPMLQESEKPKTEIIKVDQ---------SHSEDN---TYQSLVEQLDQEREKRWRAEQAE 444
              +++E+E  K + I++++         S +E N    YQ L E+     + +   E ++
Sbjct: 825  --LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882

Query: 445  NKL-MDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKL 503
            NK  ++Y  +L K  NE+  +  +   TT ++K  +F E  +         ++   ++K 
Sbjct: 883  NKQELEYKSKL-KALNEELHLQRINP-TTVKMKSSVFDEDKT---FVAETLEMGEVVEKD 937

Query: 504  TVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQA---AQIRLIQEVELKASAADREI 560
            T ELM+  +  +     L      L +  +QK  + +    +++ +++ + + S   RE+
Sbjct: 938  TTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997

Query: 561  YLLRTSLHREREQA--QQLHQLL------ALKEQEHRKELETREFFTDADF--QDALAKE 610
             ++      E  Q+   Q+  LL        +  E       + F  ++    +D ++ E
Sbjct: 998  EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057

Query: 611  --IAKEEKKHEQMIKEY---------------------QEKIDVLSQQYMDLENEF---R 644
                 EE K EQ+I ++                     Q++++VL  +  DL  +    R
Sbjct: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117

Query: 645  IALT-VEARRFQDVKDGFENVATE-LAKSKHALIWAQR-----------------KENES 685
            I L+ V +     V++  EN   + L   K  LI+AQ                  K  E+
Sbjct: 1118 ICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQET 1177

Query: 686  SSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIE---DDKQKS------- 735
                K L  ++ + +  ++E      +T  ++  +  T  +  E   +DK+ S       
Sbjct: 1178 GDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN 1237

Query: 736  ---------IQIELLKHEKVQLISELAAKESLIFGLRTE-RKVWGHELAQQGSSLAQNRG 785
                      +++  +     L++++  + + +  L+T   K+WG    QQ   +     
Sbjct: 1238 EDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWG----QQTDGM----- 1288

Query: 786  KLEAQIESLSREN-ECL----RKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI 840
            KLE   E+L +E  E L    + TN  D D +  K K+   Q     KL++ +QE +  I
Sbjct: 1289 KLEFGEENLPKEETEFLSIHSQMTNLEDID-VNHKSKLSSLQDLEKTKLEEQVQELESLI 1347

Query: 841  KRLQEKITEIEKCTQEQLDEKSSQLDEVLE 870
              LQ+++ E E+  + ++     +L  V E
Sbjct: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377



 Score = 38.5 bits (88), Expect = 0.033
 Identities = 96/553 (17%), Positives = 211/553 (38%), Gaps = 74/553 (13%)

Query: 518  LKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQL 577
            +K    + K LEK  +++ +++ A++ +   +     A  ++  L R S  +E   + + 
Sbjct: 1422 VKEETNIVKLLEKQYQEQLEEEVAKVIVSMSI-----AFAQQTELSRISGGKENTASSKQ 1476

Query: 578  HQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYM 637
               +  +EQ +  E++  +        + +  +  +E K   + + E+ ++I + +    
Sbjct: 1477 AHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH 1536

Query: 638  DLENEFRIALTVEARRF---------QDVKDGFENVATELAKSKHALIWAQRKENESSSL 688
            D+       LT+    F         Q + D  E   + +  S+  ++  ++ E+    L
Sbjct: 1537 DIPESKDCVLTISEEMFSKDKTFIVRQSIHD--EISVSSMDASRQLMLNEEQLEDMRQEL 1594

Query: 689  IKDLTCMVKEQKTKLAEVSKLKQ-----ETAANLQNQINTLEILIEDDKQKSIQIELLKH 743
            ++       +Q T+L   + ++Q     E    LQ +I  L   +   ++ SI  E L  
Sbjct: 1595 VRQY--QEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA--QRSSIDNENLVS 1650

Query: 744  EKVQ-LISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQI----------- 791
            E+ + L+ EL A + L    R +        + Q  +  +N+G++E Q            
Sbjct: 1651 ERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPE 1710

Query: 792  ----ESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKL------KDCLQEKDEHIK 841
                E LS E   L+K N      L    K      ETI +       +    +    + 
Sbjct: 1711 DVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLI 1770

Query: 842  RLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLK----GKEVELEEIR 897
               E    ++ C  E   E +   DE +      +  +  +    K    G E+    +R
Sbjct: 1771 WRSEAEASVKSCVHE---EHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR 1827

Query: 898  KAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMD 957
              ++       ++ EL+ ++ ++++   EK       L+A  + S +L+   + +   M 
Sbjct: 1828 SGFAGTEIDPENE-ELMLNISSRLQAAVEKL------LEAISETSSQLEHAKVTQTELMR 1880

Query: 958  DAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 1017
            ++F+++             Q A E  KC +    ++H+  +   +L  E  K +  ++  
Sbjct: 1881 ESFRQK-------------QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGY 1927

Query: 1018 IKQLAFALNEIQQ 1030
              +      +IQ+
Sbjct: 1928 ADEKTLFERQIQE 1940



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 89/471 (18%), Positives = 174/471 (36%), Gaps = 73/471 (15%)

Query: 281  EPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSI-------DNVLEKDPRPKRDTDITS 333
            E  K + E+  Q  ++L  L +Q  QLLNE+   I       D  L ++     +  +  
Sbjct: 3243 EDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLL 3302

Query: 334  ESDYGNRKECNRKVPR-----------------RSKIPYDAKTIQTIKHHNKNYNSFVSC 376
            ES+    +E +  + R                 R  +P +    +  K   + ++  V  
Sbjct: 3303 ESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVEL 3362

Query: 377  NRKMKPPYLKELYVSSSL-----ANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLD 431
              + +   L  L     +      +   LQ  ++  TE  K  + H   +  + L  QL+
Sbjct: 3363 LNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQK--KMHELQSKVEDLQRQLE 3420

Query: 432  QEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKE-IIFRERNSKGQLE 490
            ++R++ ++ +    +L   + E  K   E+E+      +    L E   +   + + +  
Sbjct: 3421 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3480

Query: 491  VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQE-- 548
            V+  K++ E K+     +   +       H   LE     M RQK Q  A++++++ +  
Sbjct: 3481 VLQQKIEGETKESNYAKLIEMNGGGTGCNH--ELE-----MIRQKLQCVASKLQVLPQKA 3533

Query: 549  -VELKASAADREIYLL------RTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDA 601
               L+   AD E ++          L  ++   QQ  +   +        L  R    +A
Sbjct: 3534 SERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNA 3593

Query: 602  DFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGF 661
            +    ++ ++ +E+     M+ + +E+I    Q     +N  R +L           +G 
Sbjct: 3594 ELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSL-----------NGG 3641

Query: 662  ENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQE 712
             N+   +A  K   +W + K     SL           K   AEV KLK E
Sbjct: 3642 ANIEAIIASEKE--VWNREKLTLQKSL-----------KRAEAEVYKLKAE 3679


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.129    0.350 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,447,584
Number of Sequences: 37866
Number of extensions: 1618911
Number of successful extensions: 21018
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 426
Number of HSP's successfully gapped in prelim test: 1324
Number of HSP's that attempted gapping in prelim test: 8292
Number of HSP's gapped (non-prelim): 6448
length of query: 1032
length of database: 18,247,518
effective HSP length: 112
effective length of query: 920
effective length of database: 14,006,526
effective search space: 12886003920
effective search space used: 12886003920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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