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Search of human proteins with 117414154
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117414154 sodium channel associated protein 2 isoform b
[Homo sapiens]
(939 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117414154 sodium channel associated protein 2 isoform b [Homo... 1842 0.0
gi|117414162 sodium channel associated protein 2 isoform a [Homo... 1819 0.0
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 115 2e-25
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 115 2e-25
gi|71061468 centromere protein E [Homo sapiens] 111 3e-24
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 108 2e-23
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 108 2e-23
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 108 2e-23
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 108 2e-23
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 108 2e-23
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 108 3e-23
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 105 2e-22
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 105 3e-22
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 103 6e-22
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 103 8e-22
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 103 8e-22
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 102 1e-21
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 102 1e-21
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 100 5e-21
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 100 5e-21
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 100 6e-21
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 100 6e-21
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 100 6e-21
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 100 6e-21
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 100 8e-21
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 100 8e-21
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 99 2e-20
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 98 3e-20
gi|148746195 trichohyalin [Homo sapiens] 98 4e-20
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 97 5e-20
>gi|117414154 sodium channel associated protein 2 isoform b [Homo
sapiens]
Length = 939
Score = 1842 bits (4771), Expect = 0.0
Identities = 939/939 (100%), Positives = 939/939 (100%)
Query: 1 MYASWTKACRGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHL 60
MYASWTKACRGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHL
Sbjct: 1 MYASWTKACRGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHL 60
Query: 61 LQCMVGLHFLTNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEIN 120
LQCMVGLHFLTNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEIN
Sbjct: 61 LQCMVGLHFLTNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEIN 120
Query: 121 SSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSF 180
SSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSF
Sbjct: 121 SSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSF 180
Query: 181 MSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITS 240
MSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITS
Sbjct: 181 MSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITS 240
Query: 241 ESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSS 300
ESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSS
Sbjct: 241 ESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSS 300
Query: 301 LANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDE 360
LANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDE
Sbjct: 301 LANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDE 360
Query: 361 LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 420
LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ
Sbjct: 361 LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 420
Query: 421 QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 480
QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ
Sbjct: 421 QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 480
Query: 481 AQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLS 540
AQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLS
Sbjct: 481 AQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLS 540
Query: 541 QQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLT 600
QQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLT
Sbjct: 541 QQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLT 600
Query: 601 CMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELA 660
CMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELA
Sbjct: 601 CMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELA 660
Query: 661 AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALR 720
AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALR
Sbjct: 661 AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALR 720
Query: 721 IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE 780
IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE
Sbjct: 721 IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE 780
Query: 781 RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 840
RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK
Sbjct: 781 RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 840
Query: 841 KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 900
KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV
Sbjct: 841 KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 900
Query: 901 HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 939
HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM
Sbjct: 901 HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 939
>gi|117414162 sodium channel associated protein 2 isoform a [Homo
sapiens]
Length = 1032
Score = 1819 bits (4712), Expect = 0.0
Identities = 929/929 (100%), Positives = 929/929 (100%)
Query: 11 GLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFL 70
GLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFL
Sbjct: 104 GLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLHFL 163
Query: 71 TNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGL 130
TNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGL
Sbjct: 164 TNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNIFGEPVNLTEINSSQLQCLEGL 223
Query: 131 LDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPE 190
LDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPE
Sbjct: 224 LDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPE 283
Query: 191 KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKEC 250
KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKEC
Sbjct: 284 KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKEC 343
Query: 251 NRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQES 310
NRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQES
Sbjct: 344 NRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQES 403
Query: 311 EKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKED 370
EKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKED
Sbjct: 404 EKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKED 463
Query: 371 IHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRT 430
IHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRT
Sbjct: 464 IHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRT 523
Query: 431 LEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLAL 490
LEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLAL
Sbjct: 524 LEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLAL 583
Query: 491 KEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEF 550
KEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEF
Sbjct: 584 KEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEF 643
Query: 551 RIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKL 610
RIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKL
Sbjct: 644 RIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKL 703
Query: 611 AEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLR 670
AEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLR
Sbjct: 704 AEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLR 763
Query: 671 TERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQT 730
TERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQT
Sbjct: 764 TERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQT 823
Query: 731 ETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLK 790
ETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLK
Sbjct: 824 ETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLK 883
Query: 791 QQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSI 850
QQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSI
Sbjct: 884 QQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSI 943
Query: 851 ELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMREL 910
ELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMREL
Sbjct: 944 ELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMREL 1003
Query: 911 LEETCKNKKTMEAKIKQLAFALNEIQQDM 939
LEETCKNKKTMEAKIKQLAFALNEIQQDM
Sbjct: 1004 LEETCKNKKTMEAKIKQLAFALNEIQQDM 1032
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 115 bits (288), Expect = 2e-25
Identities = 154/751 (20%), Positives = 307/751 (40%), Gaps = 89/751 (11%)
Query: 203 KLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPY 262
+LQKL + +L + +N+L+K E DY +E + ++
Sbjct: 289 ELQKLKSSVNELTQKNQTLTENLLKK------------EQDYTKLEE------KHNEESV 330
Query: 263 DAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQ 322
K IQ H + L ++V S + ++K K E+ +V+
Sbjct: 331 SKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG----EATQKLKEELSEVET 386
Query: 323 SHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR- 381
YQ L + Q +++R EQ +L I++LH LL T+R
Sbjct: 387 K------YQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK-----------LLETERQ 429
Query: 382 LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ 441
L E R + + + + ++ L ++L + ++Q ++ + + L+ L+K ++Q
Sbjct: 430 LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ 489
Query: 442 KRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL-ALKEQEHRKELE 500
++QQA Q Q K A ++ + + + ++ Q L LL KE E E
Sbjct: 490 HQEQQALQ----QSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKE 545
Query: 501 TREFFTD---ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVE 557
+ + + + A+ ++ ++ ++ + + EK+ S+ + + + +
Sbjct: 546 REDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQ 605
Query: 558 ARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLK 617
+ +D ++ T + + L NES + L +K + L K
Sbjct: 606 KAHLRAAQDRVLSLETSVNELNSQL-------NESKEKVSQLDIQIKAKTELLLSAEAAK 658
Query: 618 QETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWG 677
A+LQN ++T + ++D +Q ++ + + Q+ ++L K+ L + K
Sbjct: 659 TAQRADLQNHLDTAQNALQDKQQ---ELNKITTQLDQVTAKLQDKQEHCSQLESHLK--- 712
Query: 678 HELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLK 737
E ++ SL Q +LE QI+ L E+DS ++ + + R+L
Sbjct: 713 -EYKEKYLSLEQKTEELEGQIKKL-----------EADSLEVKASKEQALQDLQQQRQLN 760
Query: 738 DCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQL---- 793
L+ + + + E EI T+ L +KS L+ + +KL + E K+ LKQ
Sbjct: 761 TDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS 820
Query: 794 KGKEVELEEIRKAYST----LNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKS 849
+ +++ EE+ T L + +K L+ L T VK+ K + K K+E +K
Sbjct: 821 QETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST-VKDKLSKVSDSLKNSKSEFEKE 879
Query: 850 IELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRE 909
+ K A+ L K Q+ +E E E +K ++ HQ++ E+
Sbjct: 880 NQKGKAAILDLEKTCKELKHQLQVQMENTLKE----QKELKKSLEKEKEASHQLKLELNS 935
Query: 910 LLEETCKNKKTM---EAKIKQLAFALNEIQQ 937
+ E+ + + T+ E + +QL +NE++Q
Sbjct: 936 MQEQLIQAQNTLKQNEKEEQQLQGNINELKQ 966
Score = 106 bits (264), Expect = 1e-22
Identities = 160/812 (19%), Positives = 347/812 (42%), Gaps = 79/812 (9%)
Query: 186 SSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYG 245
SSE + + ++KL +L++Q+ + + S + + L+K + ++ +S
Sbjct: 444 SSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN-STELQHQLDKTKQQHQEQQALQQSTTA 502
Query: 246 NRKECNRKVPRRSKIPYDA----KTIQTIKHHNKNYNSFVSCNR-----KMKPPYLKELY 296
+E + + + D + ++ + +K S + R K++ +
Sbjct: 503 KLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV 562
Query: 297 VSSSLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMD 356
++ LQE TE +K +QS S ++L +Q+ +++ A+ L
Sbjct: 563 LNQLQEKNHTLQEQVTQLTEKLK-NQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLET 621
Query: 357 YIDELHKHANE-KEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKL----------QN 405
++EL+ NE KE + L + + + ++ E Q + + L Q
Sbjct: 622 SVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681
Query: 406 EIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMER------QKRQQQAAQIRLIQEVELK 459
E+ K+T +L + + +D +H LE L++ + QK ++ QI+ ++ L+
Sbjct: 682 ELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 460 ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIA 519
A+ + ++ +Q +QL+ L L+ E K+LE + + D K A
Sbjct: 742 VKASKEQAL-------QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794
Query: 520 KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIA-------LTVEARRFQDVKDGFENVA 572
E K Q + + +E+ +L Q + L E +I + Q VK E +
Sbjct: 795 LESIK--QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALM 852
Query: 573 TELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINT-L 631
TEL+ K L S SL + KE + A + L ++T L++Q+ +
Sbjct: 853 TELSTVKDKL------SKVSDSLKNSKSEFEKENQKGKAAILDL-EKTCKELKHQLQVQM 905
Query: 632 EILIEDDKQKSIQIELLKHEKVQLISEL-AAKESLIFGLRTERKVWGHELAQQGS--SLA 688
E +++ K+ +E K QL EL + +E LI T ++ E QG+ L
Sbjct: 906 ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELK 965
Query: 689 QNRGKLEAQIESLSRE------------NECLRKTNESDSDALRIKCKI------IDDQT 730
Q+ + + QIE+L E N+ ++ ++ + K KI +
Sbjct: 966 QSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQ 1025
Query: 731 ETIRKLKDCLQEKDEHIKRLQEKITEIEK---CTQEQLDEKSSQLDEVLEKLERHNERKE 787
ET ++L+ ++ + ++ + +E+ QE L +Q+ + ++ K
Sbjct: 1026 ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKA 1085
Query: 788 KLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERD 847
L+Q KE +L+E KA + ++ K + L + ++++ E++E +EK++ +
Sbjct: 1086 TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145
Query: 848 KSIELQKNAMEKLHSMDDAFKRQVDAIVEAH-QAEIAQLANEKQKCIDSANLKVHQIEKE 906
+ + +++++ ++ DA + + +E +A+ + A E++K + + Q++KE
Sbjct: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEK--RNQQILKDQVKKE 1203
Query: 907 MRELLEETCKNKKTMEAKIKQLAFALNEIQQD 938
EL +E + + + ++IK+ + + +++
Sbjct: 1204 EEELKKEFIEKEAKLHSEIKEKEVGMKKHEEN 1235
Score = 97.4 bits (241), Expect = 5e-20
Identities = 150/711 (21%), Positives = 300/711 (42%), Gaps = 105/711 (14%)
Query: 295 LYVSSSLANCPMLQESEKPKTEIIKVDQSHS--EDNTYQSLVEQLDQER---EKRWRAEQ 349
L SS + Q+ E+ +TE + Q E Q E D + E+R E
Sbjct: 129 LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 350 AENKLMDYIDELHKHANEKED----------IHSLALL--------------------TT 379
AE K+ +EL+K A +D I +A+L +
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 380 DRLKEIIFRERNSKGQLEVMVHKLQNEIKK-------LTVELMKAKDQQEDHLKHLRTLE 432
++LK+ + ++ E + +L++E+ K EL K K + + +TL
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
Query: 433 KTLEKMER------QKRQQQAAQIRLI-----------QEVELKASAADREIYLLRTSLH 475
+ L K E+ +K +++ + I Q+++ + SA++ ++ + L
Sbjct: 309 ENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELS 368
Query: 476 REREQAQQLHQLLALKE-------------QEHRKELETREFFTDADFQDALAKEIAKEE 522
+ E Q+L + L+ E Q+ R+E E ++ + L ++ + E
Sbjct: 369 EKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI-NQLHSKLLETE 427
Query: 523 KKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHAL 582
++ + +E+ + S++ MD E + +R + +K+ N +TEL +H L
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTN-STEL---QHQL 483
Query: 583 IWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKS 642
+++ E +L + T ++E + L +V + + +QN LE L++ K+
Sbjct: 484 DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN----LEALLQKSKE-- 537
Query: 643 IQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLS 702
I LL+ E+ L +++ A E + + + H L +Q + L + KL+ Q ES
Sbjct: 538 -NISLLEKEREDLYAKIQAGEGET-AVLNQLQEKNHTLQEQVTQLTE---KLKNQSESHK 592
Query: 703 RENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQ 762
+ E L + LR + ++ +L L E E + +L +I K
Sbjct: 593 QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI----KAKT 648
Query: 763 EQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLC 822
E L S++ + ++ + N + + L+ K+ EL +I + K DK E
Sbjct: 649 ELL--LSAEAAKTAQRADLQN-HLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCS 705
Query: 823 HLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAF-----KRQVDAIVEA 877
LE+ +KE KEK+ + E+K + + +L+ +++E S + A +RQ++ +E
Sbjct: 706 QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765
Query: 878 HQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 928
E+++ +++ + S L ++K+ L E+ K K T + + KQ+
Sbjct: 766 RATELSKQLEMEKEIVSSTRL---DLQKKSEAL--ESIKQKLTKQEEEKQI 811
Score = 89.4 bits (220), Expect = 1e-17
Identities = 157/786 (19%), Positives = 327/786 (41%), Gaps = 103/786 (13%)
Query: 120 NSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTS 179
+ S Q E L D + + L ++D ++ + +L ++ S D + +
Sbjct: 588 SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ-LDIQIKA 646
Query: 180 FMSVCQSSEPEKNNHENDLQNEIKLQK--LDDQILQLLNETSNSIDNVLEKDPRPKRDTD 237
+ S+E K DLQN + + L D+ Q LN+ + +D V K + K++
Sbjct: 647 KTELLLSAEAAKTAQRADLQNHLDTAQNALQDK-QQELNKITTQLDQVTAK-LQDKQEHC 704
Query: 238 ITSESDYGNRKECNRKVPRRS--------KIPYDAKTIQTIKHH---NKNYNSFVSCNRK 286
ES KE + +++ K+ D+ ++ K + ++ + +
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLE 764
Query: 287 MKPPYL-KELYVSSSLANCPML---QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQERE 342
++ L K+L + + + L ++SE ++ K+ + E + E L QE
Sbjct: 765 LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET- 823
Query: 343 KRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHK 402
+ + E+ N++ + EL K EKE + + D+L ++ +NSK + E K
Sbjct: 824 -KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQK 882
Query: 403 LQNEIKKLTVELMKAKDQ----QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVEL 458
+ I L + K Q E+ LK + L+K+LEK E++ Q ++ +QE +
Sbjct: 883 GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK-EKEASHQLKLELNSMQEQLI 941
Query: 459 KASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEI 518
+A T E+E+ Q + LK+ +K+ + + + A+ ++
Sbjct: 942 QAQ---------NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL--QGELKIAVLQKT 990
Query: 519 AKEEKKHEQMIKEYQE------KIDVLSQQY-------MDLENEFRIALTVEARRFQDVK 565
E K +Q+ + QE KI VL Y L+++F + QD+K
Sbjct: 991 ELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
Query: 566 D-------------------GFENVATELAKSKHALIW--AQRKENESSSLIKDLTCMVK 604
G +N + K+ A + + +KE + K L + K
Sbjct: 1051 SVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQK 1110
Query: 605 E----------QKTKLAEVSKLK-----QETAANLQNQINTLEILIEDDKQKSIQIELLK 649
E +K+KLAE+ ++K + T N + + + LE + E K + +LL
Sbjct: 1111 EKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAK-QLLI 1169
Query: 650 HEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR 709
+K++L + + ++ + + +++ ++ ++ L + + EA++ S +E E
Sbjct: 1170 QQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGM 1229
Query: 710 KTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKR----LQEKITEIEKCTQEQL 765
K +E + L ++ +++ T++K Q + +++ L+ +I +E Q
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQ 1289
Query: 766 DEKSSQLDEVLE---KLERHNERKEKLKQQLKGKEVELEEIR--------KAYSTLNRKW 814
DE+ + L+ L+ ++E+ + +L+++L ++E+ K LNRKW
Sbjct: 1290 DERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKW 1349
Query: 815 HDKGEL 820
+ E+
Sbjct: 1350 AEDNEV 1355
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 115 bits (288), Expect = 2e-25
Identities = 192/837 (22%), Positives = 351/837 (41%), Gaps = 148/837 (17%)
Query: 195 ENDLQNEIK--LQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNR 252
E + Q ++K L+K + L++ E LE+ K+ I +ES+ R
Sbjct: 504 EREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKA--ILTESENKLRDLQQE 561
Query: 253 KVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKM-KPPYLKELYVSSSLANCPMLQESE 311
R++I +++ NKN + ++ + + K + KE+ V + E
Sbjct: 562 AETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV---------MVEKH 612
Query: 312 KPKTEIIKVDQSHSEDNTYQSLVEQLDQEREK-RWRAEQAENKLMD--------YIDELH 362
K + E +K Q Q L +Q E EK R + EQ + L+ +I+E++
Sbjct: 613 KTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMN 672
Query: 363 KHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQE 422
+ EK D+ L + + + R HKL+ E+ L + K K + E
Sbjct: 673 EKTLEKLDVKQTELESLSSELSEVLKAR----------HKLEEELSVLKDQTDKMKQELE 722
Query: 423 DHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQ 482
KM+ QK Q +I+E E+ ++ + ++Q
Sbjct: 723 -------------AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL----------KDQIN 759
Query: 483 QLHQLLA-----LKE-QEHRKELETREFFTDADFQDALAKEI---AKEEKKHEQMIKEYQ 533
QL LL LKE Q H + LE ++ + Q A AK + + HEQ K Y+
Sbjct: 760 QLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQT-KAYE 818
Query: 534 EKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK-HALIWAQRKENES 592
E++ L Q+ +DLE E RI LT + + K ++V TEL K Q+ E ++
Sbjct: 819 EQLAQLQQKLLDLETE-RILLTKQVAEVEAQK---KDVCTELDAHKIQVQDLMQQLEKQN 874
Query: 593 SSLIKDLTCMVKEQKTKLAEVSKLKQETAANL-----------QNQINTLEILIEDDKQK 641
S + + + + + ++KL + +K +++T L + Q +EIL + K
Sbjct: 875 SEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK 934
Query: 642 SIQIELLKHE----------KVQLISELAAK--ESLIFGLRTERKVWGHELAQQGSSLAQ 689
I +L E K++ + + A + E+L L + EL L+Q
Sbjct: 935 EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQ 994
Query: 690 NRGKLEAQIESLSRENEC-------LRKTNESD-------------SDALRIKCKIIDDQ 729
+ A++ +++ N +TN+ + +D + I K ++ Q
Sbjct: 995 KEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQ 1054
Query: 730 TETIRKLKDC-LQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQL-------DEVLEKLER 781
E ++++ + LQEK++ + L++KI + C +E+++++ + L D L +L+
Sbjct: 1055 AEELQEIHEIQLQEKEQEVAELKQKIL-LFGCEKEEMNKEITWLKEEGVKQDTTLNELQE 1113
Query: 782 HNERKE-----------KLKQQLKGKEVELEEIRKAYSTLNRKW--------HDK---GE 819
++K KLK L+ EV+L + K + L + DK E
Sbjct: 1114 QLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSE 1173
Query: 820 LLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQ 879
L L+T +E + + EK K+ DKS+E +K + E +D K+ +A++EA
Sbjct: 1174 LTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKK-TEALLEAKT 1232
Query: 880 AEIAQLANEKQKCIDSANLKV-HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEI 935
E+ +++ K I S H+ K LL +TC + +EA+++QL N +
Sbjct: 1233 NELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSE-LEAQLRQLTEEQNTL 1288
Score = 110 bits (275), Expect = 6e-24
Identities = 157/676 (23%), Positives = 308/676 (45%), Gaps = 72/676 (10%)
Query: 308 QESEKPKTEIIKVDQSH----SEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHK 363
+E EK + K +++ +E + +E+ +E + E + K + +D + K
Sbjct: 414 EELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVK-QEVVDVMKK 472
Query: 364 HANEK----EDIHS--LALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKA 417
+ E+ + +H LA + K++ RER + Q++V + K Q+E K++ E
Sbjct: 473 SSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE---- 528
Query: 418 KDQQED------HLKHLRTLEKTLEKMERQKRQQQAAQIRLIQ-EVELKASAADREIYLL 470
K+QQE L+ L ++ K+ +++ + + R+++ E L+ S + +
Sbjct: 529 KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588
Query: 471 RTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALA-------KEIAKEEK 523
++H E E+ + ++ + E+ H+ ELE+ + DA + + L E+ K +
Sbjct: 589 DLAVHLEAEKNKHNKEITVMVEK-HKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE 647
Query: 524 KHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG-FENVATELAKSKHAL 582
K EQ + + +++ Q +++ NE T+E DVK E++++EL++ +
Sbjct: 648 KCEQEKETLLKDKEIIFQAHIEEMNE----KTLEKL---DVKQTELESLSSELSE----V 696
Query: 583 IWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDD---- 638
+ A+ K E S++KD T +K++ A++ + K + + I E+ I+
Sbjct: 697 LKARHKLEEELSVLKDQTDKMKQELE--AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKAL 754
Query: 639 KQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQI 698
K + Q+ELL E+ + + E A + L + K EL Q + L + A
Sbjct: 755 KDQINQLELLLKERDKHLKEHQAH---VENLEADIKRSEGELQQASAKLDVFQSYQSATH 811
Query: 699 ESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIE 758
E E L + + D + + E + KD E D H ++Q+ + ++E
Sbjct: 812 EQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLE 871
Query: 759 KCTQEQLDEKSSQLDEVLE-KLERHNERKEKLKQQLKGKEVELEEIR----KAYSTLNRK 813
K E +++K L +V E KLE N+ +E+ KQ L KE + ++R K L +K
Sbjct: 872 KQNSE-MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQK 930
Query: 814 WHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVD- 872
K + + L +E + KF+N+EKK++ + K+ E+Q+ +KL + K++++
Sbjct: 931 LSAKEDSIHILN---EEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELEN 987
Query: 873 AIVEAHQ------AEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNK-----KTM 921
+E Q A++ ++A I A ++ +KE E L E + +
Sbjct: 988 TALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIW 1047
Query: 922 EAKIKQLAFALNEIQQ 937
E K+ Q A L EI +
Sbjct: 1048 EKKLNQQAEELQEIHE 1063
Score = 104 bits (260), Expect = 3e-22
Identities = 151/735 (20%), Positives = 320/735 (43%), Gaps = 133/735 (18%)
Query: 305 PMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKH 364
P++++ KT + ++N + E + +E+ + L + +DE +
Sbjct: 270 PVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQE 329
Query: 365 ANEKEDIH---SLALLTTDR-LKEIIFRERNSKGQL---------------EVMVHKLQN 405
+ +D+H L+T R K +I + KG + E + +L++
Sbjct: 330 LEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS 389
Query: 406 EIKKLTVELMKAKDQQ--------EDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQE-- 455
IK++T + + ++Q+ E+ K L T +KT E+ R+ + + QI+ I++
Sbjct: 390 RIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKT-EEARRKLKAEMDEQIKTIEKTS 448
Query: 456 ------VELKASAADREIY-LLRTSLHREREQAQQLHQL-LALKEQEHRKELETREFFTD 507
++ + S +E+ +++ S + + Q+LH+ LA KEQE K+L+TRE
Sbjct: 449 EEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRE---- 504
Query: 508 ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG 567
+FQ+ + + EK + +K QEK S +LE + + LT + +D++
Sbjct: 505 REFQEQMKVAL---EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQE 561
Query: 568 FENVATELAKSKHALIWA-QRKENESSSLI-----------KDLTCMVKEQKTKL----- 610
E T + + + +L + Q +N+S L K++T MV++ KT+L
Sbjct: 562 AETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 621
Query: 611 ------------------AEVSKLKQETAANLQNQINTLEIL----IEDDKQKSIQ-IEL 647
E+ KL+++ + + EI+ IE+ +K+++ +++
Sbjct: 622 QQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDV 681
Query: 648 LKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLA----QNRGKLEAQIESLSR 703
+ E L SEL+ L E V + + L + + + Q++S+ +
Sbjct: 682 KQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIK 741
Query: 704 ENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIE---KC 760
E+E + E K + DQ I +L+ L+E+D+H+K Q + +E K
Sbjct: 742 EHEVSIQRTE----------KALKDQ---INQLELLLKERDKHLKEHQAHVENLEADIKR 788
Query: 761 TQEQLDEKSSQLD-------EVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 813
++ +L + S++LD E+ + + E+ +L+Q+L E E + K + + +
Sbjct: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848
Query: 814 WHDK-GELLCH-----------------LETQVKEVKEKFENKEKKLKAERDKSIELQKN 855
D EL H +E +VK + + +E+K + E++++ ++
Sbjct: 849 KKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVE 908
Query: 856 AMEKLHSMDDAFKRQVDAIVE---AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLE 912
+ M + K++++ + + A + I L E + + K+ +++++ +E+ E
Sbjct: 909 KENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQE 968
Query: 913 ETCKNKKTMEAKIKQ 927
K EAK+K+
Sbjct: 969 TLKKKLLDQEAKLKK 983
Score = 100 bits (249), Expect = 6e-21
Identities = 192/861 (22%), Positives = 357/861 (41%), Gaps = 138/861 (16%)
Query: 154 VITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQN-----EIKLQ--- 205
++T + E+ ++ T DA + Q E + + E +++ E KL+
Sbjct: 837 LLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGN 896
Query: 206 KLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAK 265
K +Q Q+L E N I L+ K++ +I ++ K+
Sbjct: 897 KEQEQTKQILVEKENMI---LQMREGQKKEIEILTQ-----------------KLSAKED 936
Query: 266 TIQTIKHHNKNYNS-FVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSH 324
+I + N+ Y + F + +KM+ K + +L +L + K K E+
Sbjct: 937 SIHIL---NEEYETKFKNQEKKMEKVKQKAKEMQETLKK-KLLDQEAKLKKEL------- 985
Query: 325 SEDNTYQSLVEQLDQEREKRWRAEQAENK-LMDYIDELHKHANEKEDIHSLALLTTDRLK 383
+NT L ++ Q K QA + + D + L N+KE I SL + L
Sbjct: 986 --ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLE--TNQKEQIESLTEVHRRELN 1041
Query: 384 EIIF---RERNSKGQLEVMVHKLQNEIKKLTVELMKAKD-----QQEDHLKHLRTLEK-- 433
++I ++ N + + +H++Q + K+ V +K K ++E+ K + L++
Sbjct: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
Query: 434 -----TLEKMERQKRQQQAAQIRLIQ-EVELKASAADREIYLLRTSLHREREQAQQLHQL 487
TL +++ Q +Q+ A L Q E +LKA E+ L + SL +QL +L
Sbjct: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNK-SLKENTFLQEQLVEL 1160
Query: 488 LALKEQEHRK--ELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMD 545
L E++ RK EL ++ TD +FQ + HE+ K ++K S ++
Sbjct: 1161 KMLAEEDKRKVSELTSKLKTTDEEFQSL--------KSSHEKSNKSLEDK----SLEFKK 1208
Query: 546 LENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWA-----QRKENESSSLIKDLT 600
L E I L + ++ + + + N ++ SK I + Q + + + T
Sbjct: 1209 LSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1268
Query: 601 CMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISE-- 658
C V E + +L ++++ + + Q + LE K IE L EK L E
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGG 1328
Query: 659 -----LAAKESLIFGLRTERK-------VWGHELAQQG---SSLAQNRGKLEAQIE---S 700
+ KES I L+ E + EL ++ SSL++ L Q++ S
Sbjct: 1329 NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS 1388
Query: 701 LSRENECLRKTNESDSDALRIKCKIIDD------QTETIRKLK-DCLQEKD-------EH 746
LS + + + + KC+++D + +T+ K K L++ D E
Sbjct: 1389 LSEKEAAISSLRKQYDEE---KCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEW 1445
Query: 747 IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQ------LKGK-EVE 799
K+ Q + T+ + +E + + E EK E+ N KE+L QQ LKG+ E +
Sbjct: 1446 KKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDD 1505
Query: 800 LEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKA-ERDKSIELQKNAME 858
++ K S L + + + LE + + + E+ + LK + K IE K ++
Sbjct: 1506 KSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE-HKELVQ 1564
Query: 859 KLHSMDDAFKRQVDAIVEAHQAEIAQLANE----------KQKCIDSANLKVHQIEKEMR 908
KL + + + + + EA + +I L N+ K+K ++ NL V E+E++
Sbjct: 1565 KLQHFQELGEEKDNRVKEAEE-KILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623
Query: 909 ELLEETCKNKKTMEAKIKQLA 929
L + A++K+ A
Sbjct: 1624 ALEDRLESESAAKLAELKRKA 1644
Score = 89.7 bits (221), Expect = 1e-17
Identities = 171/798 (21%), Positives = 323/798 (40%), Gaps = 153/798 (19%)
Query: 200 NEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRSK 259
NE L+KLD + +L S+ + VL+ R K + +++ D ++ K
Sbjct: 672 NEKTLEKLDVKQTEL-ESLSSELSEVLKA--RHKLEEELSVLKDQTDKM----------K 718
Query: 260 IPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIK 319
+AK + HH + +S + KE VS L++ ++K
Sbjct: 719 QELEAKMDEQKNHHQQQVDSII-----------KEHEVSIQRTE-KALKDQINQLELLLK 766
Query: 320 VDQSHSEDNTYQSLVEQLDQE-REKRWRAEQAENKL---MDYIDELHKHANEKE------ 369
H ++ +Q+ VE L+ + + +QA KL Y H+ E
Sbjct: 767 ERDKHLKE--HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL 824
Query: 370 -----DIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDH 424
D+ + +L T ++ E+ ++++ +L+ HK+Q ++ L +L K + E
Sbjct: 825 QQKLLDLETERILLTKQVAEVEAQKKDVCTELDA--HKIQ--VQDLMQQLEKQNSEMEQK 880
Query: 425 LKHL-RTLEKTLEKMERQKRQQQAAQIRLIQE-------------VEL---KASAADREI 467
+K L + E LE + K Q+Q QI + +E +E+ K SA + I
Sbjct: 881 VKSLTQVYESKLE--DGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSI 938
Query: 468 YLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDAL---AKEIAKEEKK 524
++L + + ++ + + K +E ++ L+ + +A + L A E++++EK+
Sbjct: 939 HILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQ 998
Query: 525 HEQMIKEYQEK-----IDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK 579
+ E + D +S+ + + + V R DV +E + A+
Sbjct: 999 FNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEEL 1058
Query: 580 HAL--IWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIED 637
+ I Q KE E + L + + E++ E++ LK+E Q TL L E
Sbjct: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGV----KQDTTLNELQEQ 1114
Query: 638 DKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQ 697
KQKS + L ++ +L + L E SL +N E
Sbjct: 1115 LKQKSAHVNSLAQDETKLKAHLEKLE-----------------VDLNKSLKENTFLQEQL 1157
Query: 698 IESLSRENECLRKTNESDSDALRIKCKIIDDQTETIR----KLKDCLQEKDEHIKRLQEK 753
+E E RK +E S K K D++ ++++ K L++K K+L E+
Sbjct: 1158 VELKMLAEEDKRKVSELTS-----KLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEE 1212
Query: 754 I----------TE--IEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELE 801
+ TE +E T E ++ SS+ + +L ++ R K+K+ L K +
Sbjct: 1213 LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVS 1272
Query: 802 EIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLH 861
E+ + L + ++ L + +++EK EN+ K +KA+ + S+ +K A++K
Sbjct: 1273 ELE---AQLRQLTEEQNTLNISFQQATHQLEEK-ENQIKSMKADIE-SLVTEKEALQK-- 1325
Query: 862 SMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRE------LLEETC 915
Q A+EK+ CI Q++KE+ E L++E
Sbjct: 1326 ----------------EGGNQQQAASEKESCIT-------QLKKELSENINAVTLMKEEL 1362
Query: 916 KNKKTMEAKIKQLAFALN 933
K KK + + + LN
Sbjct: 1363 KEKKVEISSLSKQLTDLN 1380
Score = 89.0 bits (219), Expect = 2e-17
Identities = 173/879 (19%), Positives = 353/879 (40%), Gaps = 128/879 (14%)
Query: 115 NLTEINSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLE-----QFA 169
N + S + C+ L L + + + + ++E+ ++ I++ +L L +
Sbjct: 1329 NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSIS 1388
Query: 170 STPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKD 229
+ +A ++S + E + DL K+ L + + L + +D+ K
Sbjct: 1389 LSEKEAAISSLRKQYDEEKCELLDQVQDLS--FKVDTLSKEKISALEQ----VDDWSNKF 1442
Query: 230 PRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDA-KTIQTIKHHNKNYNSFVSC----- 283
K+ KE ++ +SK Y+ + I +K N C
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
Query: 284 ----NRKMKPPYLKELYVSSSLANCPMLQESEKPKT-------EIIKVDQSHSEDNTYQS 332
++ K E + S A L++ KT E++K + + +D ++
Sbjct: 1503 EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK-NYNQQKDIEHKE 1561
Query: 333 LVEQLD--QE--REKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFR 388
LV++L QE EK R ++AE K++ ++++ E E L+ +
Sbjct: 1562 LVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET-------KKKELEHVNLS 1614
Query: 389 ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAA 448
++ + +L+ + +L++E EL + +Q+ +K ++ L +ME ++ Q +
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK-----KQLLSQMEEKEEQYKKG 1669
Query: 449 QIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDA 508
+ E+ K +RE+++L L + ++ Q L+ + ++ +E +A
Sbjct: 1670 TESHLSELNTKLQEREREVHILEEKL--KSVESSQSETLIVPRSAKNVAAYTEQE---EA 1724
Query: 509 DFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGF 568
D Q + K Y+EKI VL + + E ++ V + + V F
Sbjct: 1725 DSQGCVQKT--------------YEEKISVLQRNLTEKE---KLLQRVGQEKEETVSSHF 1767
Query: 569 E---NVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTK--LAEVSKLKQETAAN 623
E L K +HA + K++E S+I L ++E+ K L +++E N
Sbjct: 1768 EMRCQYQERLIKLEHA----EAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKN 1823
Query: 624 LQNQINTLEILIEDDKQKSIQIELLKHEKV-QLISELAAKESLIFGLRTERKVWGHELAQ 682
LE + DD QK++Q + L + + Q I EL +S + + +V EL
Sbjct: 1824 NIQAKQNLENVF-DDVQKTLQEKELTCQILEQKIKEL---DSCLVRQKEVHRVEMEELTS 1879
Query: 683 QGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQE 742
+ L + Q++ ++ E L + E S + ++ K++ + L+ L
Sbjct: 1880 KYEKLQALQ-----QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934
Query: 743 KDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQ----------- 791
+ ++L ++I ++K + E +L E+L+K E ER+EK+KQ
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQQEL-EILKK-EYDQEREEKIKQEQEDLELKHNS 1992
Query: 792 -----------QLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 840
QL KE ELE K T+N+ + ELL + + ++ +K K+
Sbjct: 1993 TLKQLMREFNTQLAQKEQELEMTIK--ETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
Query: 841 KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLAN------------- 887
LK + E+ E++ + + Q++ + + +Q ++ Q N
Sbjct: 2051 DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQT 2110
Query: 888 ---EKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEA 923
+K I + LK + +++ L + K +K + A
Sbjct: 2111 QLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYA 2149
Score = 63.2 bits (152), Expect = 1e-09
Identities = 88/455 (19%), Positives = 194/455 (42%), Gaps = 32/455 (7%)
Query: 512 DALAKE-IAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFR----IALTVEARRFQDVKD 566
D+L KE + + ++ E+ + Y+ K L Y L+ E + I + + + + +
Sbjct: 132 DSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAE 191
Query: 567 GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAE----VSKLKQETAA 622
E + + KH E I L V K +L V LK
Sbjct: 192 LREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQL 251
Query: 623 NLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQ 682
Q ++ T E E D + ++ L + +E+L+ R + + H+ +
Sbjct: 252 EPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLL--KRCKETIQSHK--E 307
Query: 683 QGSSLAQNRGKLEAQIESLSRENECLRKTNESDS--------DALRIKCKIIDDQ----T 730
Q + L + L+ Q++ +E E ++ + ++ DA + ++ D+
Sbjct: 308 QCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIA 367
Query: 731 ETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLK 790
ET R++ + L+ K+E I +L+ +I ++ +E ++K E+LE+ +K +
Sbjct: 368 ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTE 427
Query: 791 QQLKGKEVEL-EEIRKAYSTLNRKWHDKGELLCHLETQVKEV-KEKFENKEKKLKAERDK 848
+ + + E+ E+I+ T + + L ++ +V +V K+ E + KL+ +K
Sbjct: 428 EARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK 487
Query: 849 SIELQKNAM-EKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQK----CIDSANLKVHQI 903
+ ++ + +KL + + F+ Q+ +E Q+E +++ EK++ ++ L+ I
Sbjct: 488 ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI 547
Query: 904 EKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQD 938
E L + + +T +I +L +L + Q+
Sbjct: 548 LTESENKLRDLQQEAETYRTRILELESSLEKSLQE 582
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 111 bits (278), Expect = 3e-24
Identities = 169/848 (19%), Positives = 352/848 (41%), Gaps = 122/848 (14%)
Query: 181 MSVCQSSEPEKNNHENDLQN-EIKLQKLDDQILQLLNETSNSIDNV--LEKDPRPKRDTD 237
MS Q E N +N+L+N E+ L+ ++ + L+L + + + + V + K+ + ++
Sbjct: 1150 MSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ 1209
Query: 238 ITSESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYV 297
+ E++ + + R++ + I I H K + + R+ ++
Sbjct: 1210 KSFETERDHLRGYIREIEATGLQTKEELKIAHI--HLKEHQETIDELRRSVSEKTAQIIN 1267
Query: 298 SSSLANC--------PMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQ--------LDQER 341
+ L P+L E ++ + +V ++ N + L EQ L +
Sbjct: 1268 TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIE 1327
Query: 342 EKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEII------FRERNSKGQ 395
+R R + + + I L K + + I + D+LKE I +E SK +
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 396 LEVMVHKLQNEIKKLTVEL--MKAKDQ----------------QEDHLKHLRTLEKTLEK 437
+ + + NE K+ E+ K KD QE H ++++ K +
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESH-DEMKSVAKEKDD 1446
Query: 438 MERQKRQQQAAQIRL---IQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQE 494
++R + Q+ +L I+E+ K + E+ + L + E +L L+ KE E
Sbjct: 1447 LQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506
Query: 495 HRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ------------- 541
+ E D Q+ + + KEE+ + + I E QEK++ L Q
Sbjct: 1507 ISTIQKQLEAINDK-LQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQ 1565
Query: 542 ----QYMDLENEFRIA------LTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENE 591
+ ++L N + + + E + V++ + +L ++ ++ ++ E
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQE 1625
Query: 592 SSSLIKDLTCMVKEQKTKLAEVSKLKQETAA---NLQN----QINTLEILIED------- 637
+T V E + K+ E+ LK++ NL+N I +IL E+
Sbjct: 1626 KEYQFLKMTA-VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSV 1684
Query: 638 ----DKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGK 693
D +S++ E LK E+ QL L + + E K+ L + ++ + RG
Sbjct: 1685 TKERDDLRSVE-ETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGI 1743
Query: 694 LEAQIESLSR-------ENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEH 746
+ + +S N+ L+ + + LRI + +Q ETI KL+ + EK +
Sbjct: 1744 VSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDK 1803
Query: 747 IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERK------EKLKQQLKGKEVEL 800
+ +Q+ + QE++ E + +++ + NE + E+LK+Q+K + + L
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTL 1863
Query: 801 EEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKL 860
++ L +K H+ E +++ +KE ++ E+ LK ERD+ E
Sbjct: 1864 SKLEIENLNLAQKLHENLE---EMKSVMKE-RDNLRRVEETLKLERDQLKE--------- 1910
Query: 861 HSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKT 920
S+ + R ++ E A + L+ E ++ +D K+ + ++ ++ ++ K+K
Sbjct: 1911 -SLQETKARDLEIQQELKTARM--LSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDE 1967
Query: 921 MEAKIKQL 928
++ KI++L
Sbjct: 1968 LQKKIQEL 1975
Score = 107 bits (266), Expect = 7e-23
Identities = 183/904 (20%), Positives = 381/904 (42%), Gaps = 123/904 (13%)
Query: 81 DNPVCRLPGYRAVILQTL------PQLRILDCKNIFGEPVNLTEINSSQLQCLEGLLDNL 134
D VC + L TL P ++L+ +NI S+L L DNL
Sbjct: 462 DESVCSESDVFSNTLDTLSEIEWNPATKLLNQENI-----------ESELNSLRADYDNL 510
Query: 135 VSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNH 194
V L ++E+ ++ +DE LE+ + L +S ++ +
Sbjct: 511 VLDYEQLRTEKEEMELKLKEKN-DLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVY 569
Query: 195 ENDLQNEIK-----LQKLDDQILQLLNET-SNSIDNV-------LE--KDPRPKRDTDIT 239
DL+NE+ L++ +DQI +L S ++N+ LE +DP+ + T
Sbjct: 570 NQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFD 629
Query: 240 SESDYGNRKE-----CNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKE 294
+E+ + K + + + K+ A T + +++ + Y S + +KM+ KE
Sbjct: 630 AETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKE 689
Query: 295 LYVS-SSLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAEN- 352
L + + + L + + PK + ++ + + L +++++ R
Sbjct: 690 LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSEL 749
Query: 353 -KLMDYIDELHKHANEK-EDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKL 410
L ++ L K +K E++H + E++ +E +G LE + K ++++
Sbjct: 750 KSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEE-IGKTKDDLAT- 807
Query: 411 TVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLL 470
T K+ DQ+ ++ +TL E+ + ++ + I + +A D + L
Sbjct: 808 TQSNYKSTDQE---FQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGAL 864
Query: 471 RTSL--------HREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEE 522
+T L + RE ++L+++ LKEQ LE R D+ + + +E+
Sbjct: 865 KTELSYKTQELQEKTREVQERLNEMEQLKEQ-----LENR---------DSTLQTVEREK 910
Query: 523 KKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQ-DVKDGFE-NVATELAKSKH 580
+ +++ E++ L+Q+ DL+ + + +L +E + + D+ D N+ T+
Sbjct: 911 TLITEKLQQTLEEVKTLTQEKDDLK-QLQESLQIERDQLKSDIHDTVNMNIDTQ------ 963
Query: 581 ALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQ 640
L L + + Q+T SK+ +E + NL + NT E ++ +Q
Sbjct: 964 ------------EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK-DEFQQ 1010
Query: 641 KSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIES 700
K + I+ + + + L A + +RK++ SL Q + +L+ +ES
Sbjct: 1011 KMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIF---------SLIQEKNELQQMLES 1061
Query: 701 LSRENECLR-------KTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEK 753
+ E E L+ + + + LR+ + Q E + + K+ +K+ + R ++
Sbjct: 1062 VIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDR 1121
Query: 754 ITEIEKCTQE---QLDEKSSQL---DEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAY 807
+ E+E+ +E QL EK QL E + ++++ E LK +LK KE+ LE +
Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETER 1181
Query: 808 STLNRKWHDKGELLCHLETQ---VKEVKEKFENKEKKLKA---ERDKSIELQKNAMEKLH 861
L +K ++ E + + + +KE+++ FE + L+ E + + K ++ H
Sbjct: 1182 LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH 1241
Query: 862 SMDDAFKRQVDAIVEAHQAEIAQLAN----EKQKCIDSANLKVHQIEKEMRELLEETCKN 917
+ +D + + + AQ+ N EK + V E+E+ ++E +
Sbjct: 1242 IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSET 1301
Query: 918 KKTM 921
++TM
Sbjct: 1302 QETM 1305
Score = 101 bits (252), Expect = 3e-21
Identities = 190/897 (21%), Positives = 367/897 (40%), Gaps = 184/897 (20%)
Query: 160 DELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQN----------EIKLQKLD- 208
DE + QFAST T +++ + E + ++ + E + Q ++
Sbjct: 314 DETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEK 373
Query: 209 DQILQLLNETSNSIDNVLEKDPRPKRDT---DITSESDYGNRKECNRKVPRRSKIPYDAK 265
DQ+ QLL E ++L+K K + + + S ++E K R+ ++ +
Sbjct: 374 DQLAQLLEEK-----DLLQKVQNEKIENLTRMLVTSSSLTLQQELKAK--RKRRVTWCLG 426
Query: 266 TIQTIKHHN-------------KNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESE- 311
I +K+ N K + ++ R++ E V S+ + L E E
Sbjct: 427 KINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDT--LSEIEW 484
Query: 312 KPKTEIIKVDQSHSEDNT----YQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANE 367
P T+++ + SE N+ Y +LV +Q R ++ E+ E KL K N+
Sbjct: 485 NPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEK---EEMELKL--------KEKND 533
Query: 368 KEDIHSLALLTT-DRLKEIIFRERNSKGQL---EVMVHKLQNEIKKLTVELMKAKDQQED 423
++ +L T D+ ++I N K + EV L+NE+ VEL++ K ED
Sbjct: 534 LDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSS-KVELLREK---ED 589
Query: 424 HLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQ 483
+K L+ + +K+E K + + ++K + D E +L +RE A
Sbjct: 590 QIKKLQEYIDS-QKLENIKMDLSYSLESIEDPKQMKQTLFDAET----VALDAKRESAFL 644
Query: 484 LHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQY 543
+ L LKE+ KE+A K+ E I+ YQ +++ +
Sbjct: 645 RSENLELKEK---------------------MKELATTYKQMENDIQLYQSQLEAKKKMQ 683
Query: 544 MDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 603
+DLE E + A E + + DG K L+ E + + L K+L V
Sbjct: 684 VDLEKELQSAFN-EITKLTSLIDG---------KVPKDLLCNLELEGKITDLQKELNKEV 733
Query: 604 KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 663
+E + EV L + L++ + +E L ++ + KS ++ ++ EK +L SE+ KE
Sbjct: 734 EENEALREEVILLSE-----LKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKE 788
Query: 664 SLIFGLRTERKVWGHELA------------------------QQGSSLAQNRGKLEAQIE 699
S + GL E +LA Q+ + + ++ +I
Sbjct: 789 SRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIV 848
Query: 700 SLSRENE-------CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIK---- 748
+LS+E + L+ + L+ K + + ++ + +LK+ L+ +D ++
Sbjct: 849 NLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVER 908
Query: 749 -------RLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKL------KQQLKG 795
+LQ+ + E++ TQE+ D K Q +E+ + ++ + + ++QL+
Sbjct: 909 EKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRN 968
Query: 796 KEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFE------NKEKKLKAERDKS 849
L++ ++ +TL K ++ H+E E K++F+ +K++ L+A+ ++
Sbjct: 969 ALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQT 1028
Query: 850 IELQKNAMEKLHSMDDAF-----KRQVDAIVEAHQAEIAQLANEKQKCIDS--------- 895
+ E + F K ++ ++E+ AE QL + ++ I+
Sbjct: 1029 LTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELR 1088
Query: 896 -------------ANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 939
A K H I+KE L TC +E K+K+ + L E QQ +
Sbjct: 1089 LLGDELKKQQEIVAQEKNHAIKKEGE--LSRTCDRLAEVEEKLKEKSQQLQEKQQQL 1143
Score = 92.4 bits (228), Expect = 2e-18
Identities = 167/825 (20%), Positives = 355/825 (43%), Gaps = 121/825 (14%)
Query: 198 LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 257
LQ EI + + ++L + E S + + + E + ++ T T +S R E R +
Sbjct: 1278 LQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQST--TKDSTTLARIEMER-LRLN 1334
Query: 258 SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEI 317
K + I+++ N + ++K LKE ++ +LA +QES+ + +
Sbjct: 1335 EKFQESQEEIKSLTKERDNLKTIKEA-LEVKHDQLKE-HIRETLAK---IQESQSKQEQS 1389
Query: 318 IKVDQSHSEDNTYQSLVEQLDQEREKRWRAE----QAENKLMDYIDELHKHANEKEDIHS 373
+ + + +E S +EQ + R E +L + DE+ A EK+D+
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQR 1449
Query: 374 LALLTT-------DRLKEIIFRERNSKGQLEVM---VHKLQNEIKKLTVELMKAKDQQED 423
L + + +KEI+ + ++ +L+V + + + I +L V L + + +
Sbjct: 1450 LQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIST 1509
Query: 424 HLKHLRTLEKTLE-KMERQKRQQQAAQIRLIQEVELKAS-------------AADREIYL 469
K L + L+ K++ +++ I+ I EV+ K + +A + I
Sbjct: 1510 IQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIES 1569
Query: 470 LRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDA---DFQDALAKEIAKEEKKHE 526
L +++Q+ Q++ +++E ++ E + D + ++ +AK +EK+++
Sbjct: 1570 KMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQ 1629
Query: 527 QM----IKEYQEK---IDVLSQQY----MDLEN--EFRIALTV-------EARRFQDVKD 566
+ + E QEK I+ L +Q+ ++LEN I LT E R +D
Sbjct: 1630 FLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERD 1689
Query: 567 GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVS-KLKQETAANLQ 625
+V L + L KEN ++ +DL K+++ K+ + K QET L+
Sbjct: 1690 DLRSVEETLKVERDQL-----KENLRETITRDLE---KQEELKIVHMHLKEHQETIDKLR 1741
Query: 626 -------NQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESL-----IFGLRTER 673
N+I+ ++ +E +++ + LK ++ I+ + KE + G+ +E+
Sbjct: 1742 GIVSEKTNEISNMQKDLEHSND-ALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEK 1800
Query: 674 KVWGHELAQQGSSLAQNRGKLEAQIESLSRENECL-------RKTNESDSDALRIKCKII 726
+L+ L + KL+ +I+ L L +T + S+ ++K K I
Sbjct: 1801 T---DKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK-KQI 1856
Query: 727 DDQTETIRKL------------------KDCLQEKDEHIKRLQEKITEIEKCTQEQLDEK 768
DQ+ T+ KL K ++E+D +++R++E + +E L E
Sbjct: 1857 KDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD-NLRRVEETLKLERDQLKESLQET 1915
Query: 769 SSQLDEVLEKLE-------RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELL 821
++ E+ ++L+ H E +KL++++ K +++ +I+K + K + L
Sbjct: 1916 KARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQEL 1975
Query: 822 CHLETQVKEVKEKFENKEKKLK--AERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQ 879
E Q+ VKE KK+ + K E Q +M+ + + +++ +E +
Sbjct: 1976 QKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR 2035
Query: 880 AEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 924
+A+ +E ++ +S ++ Q +RE++ +N + K
Sbjct: 2036 I-VAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEK 2079
Score = 83.6 bits (205), Expect = 8e-16
Identities = 173/918 (18%), Positives = 384/918 (41%), Gaps = 99/918 (10%)
Query: 95 LQTLPQLRILDC------KNIFGEPVNL----TEINSSQLQCLEGLLDNLVSSDSPLNIS 144
L+T +L++ C + I VNL TEI++ Q Q LE + D L + +
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQ-LEAINDKLQNKIQEIYEK 1531
Query: 145 EDEI-IDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIK 203
E++ I ++ + ++EL ++ D+ L S +S E N + Q EI+
Sbjct: 1532 EEQFNIKQISEVQEKVNELKQFKEHRKA-KDSALQSI----ESKMLELTNRLQESQEEIQ 1586
Query: 204 LQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKE--------CNRKVP 255
+ + + ++ + E +E+D + +I ++ KE N
Sbjct: 1587 IMIKEKEEMKRVQEALQ-----IERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQE 1641
Query: 256 RRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKT 315
+ +I + + +T K + +N + ++ L+E+ + ++ +
Sbjct: 1642 KMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEM------RSVTKERDDLRSVE 1695
Query: 316 EIIKVDQSHSEDNTYQSLVEQLDQEREKRW------RAEQAENKLMDYIDE-LHKHANEK 368
E +KV++ ++N +++ L+++ E + ++ +KL + E ++ +N +
Sbjct: 1696 ETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQ 1755
Query: 369 EDI-HSLALLTTDRLK---EIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDH 424
+D+ HS L LK E+ + K Q E + KL+ + + T +L + E+
Sbjct: 1756 KDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET-IDKLRGIVSEKTDKLSNMQKDLENS 1814
Query: 425 LKHLRTLEKTLEKMERQ----KRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 480
L+ + L+ E Q K+ Q ++ + +LK D+ + L + +
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN-LNL 1873
Query: 481 AQQLHQLL-----ALKEQEHRKELETREFFTDADFQDALAK------EIAKEEKKHEQMI 529
AQ+LH+ L +KE+++ + +E +++L + EI +E K +
Sbjct: 1874 AQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLS 1933
Query: 530 KEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKE 589
KE++E +D L ++ +E I ++ + KD + EL K + L+ +
Sbjct: 1934 KEHKETVDKLREKI----SEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989
Query: 590 NESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AANLQNQINTLEILIEDDKQKSIQIE 646
N S I ++ + K+ + + + ++ + L + + I+ ++ + E
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKE 2049
Query: 647 LLKHEKVQLIS---ELAAKESLIFGLRTERKVWG----------HELAQQGSSLAQNRGK 693
LK E+ Q I+ E+ A++ ++ E+++ E + L + +
Sbjct: 2050 SLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSE 2109
Query: 694 LEAQIESLSRENECLRKTNESDSD-ALRIKCKIIDD--QTETIRKL----KDCLQEKDEH 746
++ E L+R + L K E + ++R+K + QT+ I KL + C E
Sbjct: 2110 MDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRI 2169
Query: 747 IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 806
+K+L+ ++ + K +EQ + + + ++++E+ E K++ + +V E+R
Sbjct: 2170 MKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDL 2229
Query: 807 YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 866
N H + L E++ +K +F+ K E + +E N + + +
Sbjct: 2230 KLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRK-EMTQFLEEWLNTRFDIEKLKNG 2288
Query: 867 FKRQVDAIVEAH---QAEIAQLANEKQKCID---SANLKVHQIEKEMRELLEETCKNKKT 920
+++ D I + + I + NE + + + + + Q K ++E E+ KN +T
Sbjct: 2289 IQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQT 2348
Query: 921 MEAKIKQLAFALNEIQQD 938
++ + A +N QD
Sbjct: 2349 LKTSLASGA-QVNPTTQD 2365
Score = 64.7 bits (156), Expect = 4e-10
Identities = 162/832 (19%), Positives = 323/832 (38%), Gaps = 143/832 (17%)
Query: 104 LDCKNIFGEPVNLTEI---NSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRM-PVITAPI 159
L+ +NI E + LT+I N +++ + D+L S + L + D++ + + IT +
Sbjct: 1658 LNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL 1717
Query: 160 D--ELVPLEQFASTPSDAVLTSFMSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQL--- 214
+ E + + + + E +N + DL++ K D +Q
Sbjct: 1718 EKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELR 1777
Query: 215 -----LNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR-SKIPYDAKTIQ 268
L E +ID L K D + D N N K+ + ++ + +
Sbjct: 1778 IAHMHLKEQQETIDK-LRGIVSEKTDKLSNMQKDLENS---NAKLQEKIQELKANEHQLI 1833
Query: 269 TIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSHSEDN 328
T+K VS ++K +K+ ++ S L ++K + ++ E +
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQ-IKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD 1892
Query: 329 TYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFR 388
+ + E L ER++ + Q E K D E+ + + T D+L+E I
Sbjct: 1893 NLRRVEETLKLERDQLKESLQ-ETKARDL--EIQQELKTARMLSKEHKETVDKLREKISE 1949
Query: 389 ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAA 448
+ ++ + K ++E++K EL K + Q + + K + +ME+ K+Q +A
Sbjct: 1950 KTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQ 2009
Query: 449 QIRL-----------------IQEVELKASAADREIYLLRTSLHREREQ-AQQLHQLLAL 490
+ + ++E+ + A D E+ ++ SL ER+Q L +++A
Sbjct: 2010 NLSMQSVRMDNFQLTKKLHESLEEIRIVAKERD-ELRRIKESLKMERDQFIATLREMIAR 2068
Query: 491 KEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID---VLSQQYMDLE 547
Q H+ + E R +D Q L + + ++ + ++++K Y E D L++ +DLE
Sbjct: 2069 DRQNHQVKPEKRLL---SDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLE 2125
Query: 548 NEFR----IALTVEA---------RRFQDVKDGFENVATE----LAKSKHALIWAQR-KE 589
E +++ V+A + + + + + E + K K+ L + + KE
Sbjct: 2126 KEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185
Query: 590 NESSSLIK---DLTCMVKEQKTKLAEVSKLKQETAANL---------QNQINTLEILIED 637
+ S+ K D V++QK L ++ L+Q+ QN +E +++D
Sbjct: 2186 EQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKD 2245
Query: 638 DKQKSI--------QIELLKHEKVQLISELAAK----ESLIFGLRTERK----------- 674
+ Q+ + E Q + E E L G++ E
Sbjct: 2246 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNN 2305
Query: 675 ---VWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNES----------------D 715
+E + A + E ++SL +NE L K ++ D
Sbjct: 2306 RIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQD 2365
Query: 716 SDALRIKCKIIDDQTETIRKLKDCLQEKDEH---------------------IKRLQEKI 754
+ + + TE IR+L++ L E E I +LQ K+
Sbjct: 2366 NKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV 2425
Query: 755 TEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 806
E KC ++ + D+V + + E E LK +L +++LE+++ A
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL--VKIDLEKMKNA 2475
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 108 bits (271), Expect = 2e-23
Identities = 124/611 (20%), Positives = 271/611 (44%), Gaps = 67/611 (10%)
Query: 279 SFVSCNRKMKPPYLKELY-----VSSSLANCPMLQESEKPKTEII--KVDQSHSEDNTYQ 331
S V+ +K Y++EL +S L + E K K + K+ SE + Q
Sbjct: 182 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ 241
Query: 332 SLVEQLDQEREK----------RWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR 381
V++L ++ E+ + A+ +L +L E E + L +
Sbjct: 242 LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL----NQQ 297
Query: 382 LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ 441
+E ++R+ + E K+Q + +K+ + K ++Q+E + + + EKM RQ
Sbjct: 298 QEEKMWRQEEKIQEWE---EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 354
Query: 442 KRQQQAAQIRLIQEVEL---KASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKE 498
+ + ++ ++ E+ K R+ ++ + RE +++H+ ++EQE +++
Sbjct: 355 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 414
Query: 499 LETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEA 558
E ++I ++EK+ EQ K ++++ + Q+ E E ++ E
Sbjct: 415 EE---------------EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 459
Query: 559 RRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQ 618
Q E + E + + +W Q ++ I + EQ+ K+ + ++
Sbjct: 460 IHEQ------EKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRK----QE 509
Query: 619 ETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGH 678
E + +I E I + ++K + E EK++ E+ +E + + K+W
Sbjct: 510 EKVWRQEEKIREQEEKIREQEEKMWRQE----EKIREQEEMWREEEK---MHEQEKIWEE 562
Query: 679 ELAQ-QGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLK 737
E Q Q + + K+ Q E + R+ E +R+ E + K Q E IR+ +
Sbjct: 563 EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK----QEEKIREQE 618
Query: 738 DCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKL---KQQLK 794
+ +QE++E I+ +EKI E E+ TQEQ ++ Q +++ E+ E+ E++E + +++++
Sbjct: 619 EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR 678
Query: 795 GKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQK 854
+E ++ E + ++ E + E ++ E +EK + +E+K++ + +K E +
Sbjct: 679 EQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEV 738
Query: 855 NAMEKLHSMDD 865
++ M +
Sbjct: 739 RLRQQEEKMQE 749
Score = 89.0 bits (219), Expect = 2e-17
Identities = 121/601 (20%), Positives = 266/601 (44%), Gaps = 58/601 (9%)
Query: 348 EQAENKLMDYIDELH---KHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQ 404
+Q E + D I LH K A E E +L+ + T + K + E +K + + + +
Sbjct: 154 KQLEGEARDLISRLHDSWKFAGELEQ--ALSAVATQKKKADRYIEELTKERDALSLELYR 211
Query: 405 NEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAAD 464
N I ++ AK Q++ L E L E +++ ++A + Q+++ +A
Sbjct: 212 NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271
Query: 465 REIYLLRTSLHREREQAQQLHQLLALKEQEH-RKELETREFFTDADFQDALAKEIAKEEK 523
+E+ + L + E+ + ++L +E++ R+E + +E+ + +E ++ +
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEW-------EEKIQEQEEKIR 324
Query: 524 KHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALI 583
+ E+ I+E +EK+ Q+ M E E ++ RR +++ E E + + ++
Sbjct: 325 EQEEKIREQEEKMR--RQEEMMWEKEEKM------RRQEEMMWEKE----EKMRRQEEMM 372
Query: 584 WAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSI 643
W E E ++ KE+K + E +QE + + E + E +K++
Sbjct: 373 W----EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 428
Query: 644 QIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSR 703
+ ++ + E+ E +E E+K+W E + K + Q E + R
Sbjct: 429 EAKMWRQEEKIREQEEKIREQ-------EKKMWRQEEKIHEQEKIREEEKRQEQ-EEMWR 480
Query: 704 ENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQE 763
+ E + + E I Q E + + ++ +++++E + R +EKI E E+ +E
Sbjct: 481 QEEKIHEQEE------------IWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528
Query: 764 QLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCH 823
Q ++ Q +++ E+ E E ++ +Q+ +E + +E K ++ E +
Sbjct: 529 QEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR 588
Query: 824 LETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAH---QA 880
E +++E +EK + +E+K+ + +K E + EK+ ++ + Q + I E Q
Sbjct: 589 QEEKIREQEEKRQEQEEKMWKQEEKIREQE----EKIQEQEEKIREQEEKIREQEEMTQE 644
Query: 881 EIAQLANEKQKCIDSANLKVHQIEKEMR--ELLEETCKNKKTMEAKIKQLAFALNEIQQD 938
+ ++ +++K + Q E R E + E K + E KI++ + E ++
Sbjct: 645 QEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 704
Query: 939 M 939
M
Sbjct: 705 M 705
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 108 bits (270), Expect = 2e-23
Identities = 161/798 (20%), Positives = 335/798 (41%), Gaps = 97/798 (12%)
Query: 190 EKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKE 249
EKN + LQ E +L +++ L ++ +L + + + E D G + +
Sbjct: 888 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE-----MEARLEEEEDRGQQLQ 942
Query: 250 CNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQE 309
RK + + + + + K V+ K+K L++ + N + +E
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--LEDEILVMDDQNNKLSKE 1000
Query: 310 SEKPKTEIIKVDQSHSED-----------NTYQSLVEQLDQEREKRWRAEQAENKLMDYI 358
+ + I + + +E+ N ++S++ +L+ +K ++ Q KL
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK--- 1057
Query: 359 DELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAK 418
K + D H ++ E+ + + +L+ + +L +EI
Sbjct: 1058 ---RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---------- 1104
Query: 419 DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER 478
Q+ + LK +R LE + ++ ++AA+ + E + E+ L+T L
Sbjct: 1105 -QKNNALKKIRELEGHISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTL 1159
Query: 479 EQAQQLHQLLALKEQEH---RKELETREFFTDADFQDALAKEIAKEEKKHEQM--IKEYQ 533
+ +L A +EQE +K L+ +A Q+ K E+ EQ+ K +
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 534 EKID----VLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATEL----AKSKHALIWA 585
+D L ++ DL E R+ L + + K E EL + + A
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278
Query: 586 QRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK---S 642
K ++ + ++ +T M+ E + K +++K ++ LQ+ T E+L E+ +QK S
Sbjct: 1279 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQKLNVS 1335
Query: 643 IQIELLKHEKV----QLISELAAKESLIFGLRT------ERKVWGHELAQQGSSLAQNRG 692
++ L+ E+ QL E+ AK++L + T + K + A +L + +
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395
Query: 693 KLEAQIESLSRENE-------CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDE 745
+ + +IE+L+++ E L KT L +D+Q + + L+ ++ D+
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 746 HI---KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEE 802
+ K + K + + + EK ++ + LE E KE+L++ K + E+E+
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 803 IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHS 862
+ + + + H+ + LETQ++E+K + E E +L+A D + L+ N + +
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN----MQA 1571
Query: 863 MDDAFKRQVDAIVEAHQAEIAQLANE------------KQKCIDSANLKVHQIEKEMREL 910
+ F+R + A E ++ + QL + KQ+ + +A K ++E ++++L
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK--KLEGDLKDL 1629
Query: 911 LEETCKNKKTMEAKIKQL 928
+ K E IKQL
Sbjct: 1630 ELQADSAIKGREEAIKQL 1647
Score = 104 bits (259), Expect = 4e-22
Identities = 136/560 (24%), Positives = 256/560 (45%), Gaps = 70/560 (12%)
Query: 398 VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVE 457
+ V + + E++ EL K K++Q+ L+ LE+ ++ +K Q +L E E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE---QLQAETE 901
Query: 458 LKASAADREIYLLRTSLHREREQAQQLHQLLA-LKEQEHRKELETREFFTDA----DFQD 512
L A A + + L +++E + LH++ A L+E+E R + E A D ++
Sbjct: 902 LYAEAEEMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 513 ALAKEIAKEEKKH------EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKD 566
L +E A +K E IK+ +++I V+ Q L E ++ +E R + D
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEER----ISD 1010
Query: 567 GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AAN 623
N+A E K+K+ + +N+ S+I +L +K+++ E+ KLK++ A++
Sbjct: 1011 LTTNLAEEEEKAKNLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 624 LQNQINTLEILIEDDK-QKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGH--EL 680
QI L+ I + K Q + + E L+ +L E+A K + L+ R++ GH +L
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN---ALKKIRELEGHISDL 1123
Query: 681 AQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCL 740
+ S R K E Q L E E L+ E D+ + ++ + + + LK L
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 741 QEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVEL 800
DE + + ++ E+ + + ++E L E LE+ +R +K KQ L+ + +L
Sbjct: 1184 ---DEETRSHEAQVQEMRQKHAQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADL 1236
Query: 801 E-EIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 859
E+R H K +L E QV+E++ K + E+ DK +LQ N +E
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKL----EAQVQELQSKCSDGERARAELNDKVHKLQ-NEVES 1291
Query: 860 LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKK 919
+ M + + + + + ++A L+++ Q + +ELL+E + K
Sbjct: 1292 VTGMLNEAEGKAIKLAK----DVASLSSQLQ---------------DTQELLQEETRQKL 1332
Query: 920 TMEAKIKQLAFALNEIQQDM 939
+ K++QL N +Q +
Sbjct: 1333 NVSTKLRQLEEERNSLQDQL 1352
Score = 103 bits (257), Expect = 8e-22
Identities = 155/730 (21%), Positives = 310/730 (42%), Gaps = 121/730 (16%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKL----MDYIDELHK 363
+E+ + ++ ++ Q H++ + L EQL+Q + + ++ + L D EL
Sbjct: 1185 EETRSHEAQVQEMRQKHAQ--AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 364 HANEKEDIHSLALLTTDRLKEIIFR---ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 420
K+++ +++E+ + ++ +L VHKLQNE++ +T L +A+ +
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 421 QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 480
K + +L L+ + Q+ Q+ + +L V K + E L+ L E E
Sbjct: 1303 AIKLAKDVASLSSQLQ--DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 481 AQQLHQ---LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID 537
Q L + L ++ + +K+L+ +F A +AL + + +K+ E + ++Y+EK
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQ--DF---ASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 538 V--------------LSQQYMDLENEFRIALTVEA--RRFQDVKDGFENVATELAKSK-H 580
L +DL+N+ ++ +E R+F + +N++++ A +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 581 ALIWAQRKENESSSLIKDL--TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDD 638
A A+ KE ++ SL + L KE+ + ++ K + E + ++ + +E
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 639 KQK-SIQIELLKHEKVQLISELAAKESLIFGLRTERKV----WGHELAQQGSSLAQNRGK 693
K+ Q+E +K + +L EL A E L + + +L + + R +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 694 LEAQIESLSRENECLRKTN-------------------ESDS------DALRIKCKIIDD 728
L+ Q+ E E RK ++DS +A++ K+
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 729 QTETIRKLKDCLQEKDE-----------------HIKRLQEKITEIEKCTQEQLDEKSSQ 771
+ R+L+D +DE + +LQE + E+ ++ EK
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 772 LDEVLEKLERHN---ERKEKLKQQLKGKEVELEEIR---KAYSTLNRKWHDKGELLCHLE 825
+E+ L N + K +L+ ++ E ELEE + +A S RK + E L +
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 826 TQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQL 885
+ +K E+ ++L+ + K KLH M+ A K + + + A +A+IAQL
Sbjct: 1774 ATERSTAQKNESARQQLERQN-------KELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 886 -------ANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTME----------AKIKQL 928
A EKQ +A + Q +K+++E+L + +K E A++KQL
Sbjct: 1827 EEQVEQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882
Query: 929 AFALNEIQQD 938
L E +++
Sbjct: 1883 KRQLEEAEEE 1892
Score = 96.3 bits (238), Expect = 1e-19
Identities = 141/670 (21%), Positives = 285/670 (42%), Gaps = 84/670 (12%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLV-EQLDQEREKRWRAEQAENKLMDYIDELHKHAN 366
+ +K + E+ +++Q HS+ ++L+ EQL E E AE+ +L EL
Sbjct: 866 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL----- 920
Query: 367 EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 426
+E +H + E E +GQ +LQ E KK+ +++ ++Q E+
Sbjct: 921 -EEILHEM---------EARLEEEEDRGQ------QLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 427 HLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADRE-----IYLLRTSLHREREQA 481
+ L+ LEK+ + + ++ L+ + + + +R+ I L T+L E E+A
Sbjct: 965 ARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 482 QQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ 541
+ L + L K + ELE R ++ +E+ K ++K E ++ E+I L
Sbjct: 1023 KNLTK-LKNKHESMISELEVR-----LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 542 QYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTC 601
Q +L+ + A++ ++++ + E+A+ +AL + E S L +DL
Sbjct: 1077 QIAELKMQL-------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 602 ------MVKEQKTKLAE--------------VSKLKQETAANLQNQINTL-EILIEDDKQ 640
++QK L E + +QE A + ++ L + L E+ +
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 641 KSIQIELLKHEKVQLISELA--------AKESLIFGLRTERKVWG------HELAQQGSS 686
Q++ ++ + Q + EL AK +L +T K L Q
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 687 LAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEH 746
+ + KLEAQ++ L +++C E L K + ++ E++ + + + K
Sbjct: 1250 VEHKKKKLEAQVQEL--QSKC--SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 747 IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 806
+ + ++ + TQE L E++ Q V KL + E + L+ QL + + + +
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 807 YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 866
STLN + D + L + V+ ++E + +K+++ + E + A +KL +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKNR 1424
Query: 867 FKRQVDAIVE--AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 924
++++D +V +Q ++ +KQ+ D + I + + + + E K
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484
Query: 925 IKQLAFALNE 934
LA AL E
Sbjct: 1485 ALSLARALEE 1494
Score = 84.0 bits (206), Expect = 6e-16
Identities = 134/627 (21%), Positives = 269/627 (42%), Gaps = 82/627 (13%)
Query: 306 MLQESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQ-----------AENK 353
+LQE + K + K+ Q E N SL +QLD+E E + E+ ++ K
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 354 LMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVE 413
L D+ + K+ T + +E + + +LE ++LQ E+ L V+
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEE----KAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 414 LMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS 473
L ++ + + LEK K ++ +++ + E + +A A RE S
Sbjct: 1436 L-------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD-RAEAEAREKETKALS 1487
Query: 474 LHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQ 533
L R E+A + + L + + E+E + + D E+ K ++ E ++E +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 534 EKIDVLSQQYMDLEN-EFRIALTVEARRFQDVKD-----------------GFENVATEL 575
+++ L + E+ + R+ + ++A + Q +D TEL
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 576 A--KSKHALIWAQRKENESSSLIKDLTCM----VKEQKTKLAEVSKLK---QETAANLQN 626
+ + AL A +K+ E +KDL +K ++ + ++ KL+ ++ L++
Sbjct: 1606 EDERKQRALAAAAKKKLEGD--LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 627 QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGS- 685
+ + + K+ + + L+ + +QL +LAA E E++ ELA S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 686 --SLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDD-------QTETIRKL 736
+L + +LEA+I L E E + E+ SD +R + + + T +K
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 737 KDCLQEKDEHIKRLQEKITEIE-------KCTQEQLDEKSSQLDEVLEKLERHNERKEK- 788
+ Q+ + K L+ K+ E+E K T L+ K +QL+E +E+ R + K
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 789 LKQQ---LKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFEN---KEKKL 842
LKQ+ LK +++E+ RK + + L+ Q++E +E+ + +KL
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903
Query: 843 KAERDKSIELQKNAMEKLHSMDDAFKR 869
+ E D++ E + +++++ +R
Sbjct: 1904 QRELDEATESNEAMGREVNALKSKLRR 1930
Score = 81.3 bits (199), Expect = 4e-15
Identities = 96/457 (21%), Positives = 203/457 (44%), Gaps = 61/457 (13%)
Query: 487 LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE---YQEKIDVLSQQY 543
LL + QE + + E + Q E+ + E+KH Q+ +E QE++ ++ Y
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 544 MDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 603
+ E E R+ L + + +++ E E + + + A+RK+ L DL +
Sbjct: 904 AEAE-EMRVRLAAKKQELEEILHEME-ARLEEEEDRGQQLQAERKKMAQQML--DLEEQL 959
Query: 604 KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIE--LLKHEKVQLISELAA 661
+E++ ++ K A ++ + EIL+ DD+ + E LL+ L + LA
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLED--EILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 662 KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC-LRKTNESDSDALR 720
+E A+N KL+ + ES+ E E L+K +S + +
Sbjct: 1018 EE----------------------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055
Query: 721 IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE 780
+K K+ D ++ ++ D LQ + +K K E + +LD++ +Q + L+K+
Sbjct: 1056 LKRKLEGDASDFHEQIAD-LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI- 1113
Query: 781 RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 840
+L+ + + +L+ R A + ++ D GE L L+T++++ + ++
Sbjct: 1114 ------RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQ 1166
Query: 841 KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 900
+L+A+R++ + + K A+ D +H+A++ ++ + + ++ ++
Sbjct: 1167 ELRAKREQEVTVLKKAL--------------DEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 901 HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 937
Q ++ L KNK+T+E + LA L + Q
Sbjct: 1213 EQFKRAKANL----DKNKQTLEKENADLAGELRVLGQ 1245
Score = 75.1 bits (183), Expect = 3e-13
Identities = 138/648 (21%), Positives = 280/648 (43%), Gaps = 83/648 (12%)
Query: 198 LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 257
LQ E + + L+ L E NS+ + L+++ K++ + S + ++K
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSDSKK---- 1378
Query: 258 SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEI 317
K+ A T++ ++ K + + L + Y + A + EK K +
Sbjct: 1379 -KLQDFASTVEALEEGKKRFQKEIE--------NLTQQYEEKAAA----YDKLEKTKNRL 1425
Query: 318 IK-VDQSHSEDNTYQSLVEQLDQEREK--RWRAEQAE--NKLMDYIDELHKHANEKED-I 371
+ +D + + + LV L++++ K + AE+ +K D D A EKE
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 372 HSLALLTTDRLKEIIFRERNSK---GQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHL 428
SLA + L+ ER +K ++E +V ++++ K EL K+K E ++ +
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEM 1544
Query: 429 RTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL 488
+T LE++E + + + A++RL EV ++A E L EQ ++ + L
Sbjct: 1545 KT---QLEELEDELQATEDAKLRL--EVNMQALKGQFE-----RDLQARDEQNEEKRRQL 1594
Query: 489 ALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLEN 548
+ E+ ELE D Q ALA A +KK E +K+ + + D + +
Sbjct: 1595 QRQLHEYETELE------DERKQRALA---AAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 549 EFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKT 608
+ R L + + FQ E A++ I+A KENE + + M ++
Sbjct: 1646 QLR-KLQAQMKDFQR--------ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 609 KLAEVSKL-----KQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 663
AE ++ K+E A L + ++ L ++ ++ +I L+ E + + A
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 664 SLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR-KTNESDSD----- 717
+ + + +ELA + S+ +N E+ + L R+N+ LR K +E +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKN----ESARQQLERQNKELRSKLHEMEGAVKSKF 1812
Query: 718 -----ALRIKCKIIDDQTETIRKLKDC----LQEKDEHIKRLQEKITEIEKCTQ---EQL 765
AL K +++Q E + K L++KD+ +K + ++ + K + EQ
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872
Query: 766 DEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 813
++ ++++ ++ +LE E +++ + + EL+E ++ + R+
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/200 (24%), Positives = 99/200 (49%), Gaps = 8/200 (4%)
Query: 735 KLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLK 794
K+K LQ + + +Q K E++K T+E+ + ++L E+ +K + E K L++QL+
Sbjct: 840 KVKPLLQVTRQE-EEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 897
Query: 795 GKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQK 854
+ E + L K + E+L +E +++E E++ ++L+AER K +
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRGQQLQAERKKMAQQML 953
Query: 855 NAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEET 914
+ E+L ++A ++++ +A+I +L +E +D N K+ + K + E + +
Sbjct: 954 DLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERISDL 1011
Query: 915 CKNKKTMEAKIKQLAFALNE 934
N E K K L N+
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNK 1031
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 108 bits (270), Expect = 2e-23
Identities = 161/798 (20%), Positives = 335/798 (41%), Gaps = 97/798 (12%)
Query: 190 EKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKE 249
EKN + LQ E +L +++ L ++ +L + + + E D G + +
Sbjct: 895 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE-----MEARLEEEEDRGQQLQ 949
Query: 250 CNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQE 309
RK + + + + + K V+ K+K L++ + N + +E
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--LEDEILVMDDQNNKLSKE 1007
Query: 310 SEKPKTEIIKVDQSHSED-----------NTYQSLVEQLDQEREKRWRAEQAENKLMDYI 358
+ + I + + +E+ N ++S++ +L+ +K ++ Q KL
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK--- 1064
Query: 359 DELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAK 418
K + D H ++ E+ + + +L+ + +L +EI
Sbjct: 1065 ---RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---------- 1111
Query: 419 DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER 478
Q+ + LK +R LE + ++ ++AA+ + E + E+ L+T L
Sbjct: 1112 -QKNNALKKIRELEGHISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTL 1166
Query: 479 EQAQQLHQLLALKEQEH---RKELETREFFTDADFQDALAKEIAKEEKKHEQM--IKEYQ 533
+ +L A +EQE +K L+ +A Q+ K E+ EQ+ K +
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 534 EKID----VLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATEL----AKSKHALIWA 585
+D L ++ DL E R+ L + + K E EL + + A
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285
Query: 586 QRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK---S 642
K ++ + ++ +T M+ E + K +++K ++ LQ+ T E+L E+ +QK S
Sbjct: 1286 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQKLNVS 1342
Query: 643 IQIELLKHEKV----QLISELAAKESLIFGLRT------ERKVWGHELAQQGSSLAQNRG 692
++ L+ E+ QL E+ AK++L + T + K + A +L + +
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402
Query: 693 KLEAQIESLSRENE-------CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDE 745
+ + +IE+L+++ E L KT L +D+Q + + L+ ++ D+
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 746 HI---KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEE 802
+ K + K + + + EK ++ + LE E KE+L++ K + E+E+
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 803 IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHS 862
+ + + + H+ + LETQ++E+K + E E +L+A D + L+ N + +
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN----MQA 1578
Query: 863 MDDAFKRQVDAIVEAHQAEIAQLANE------------KQKCIDSANLKVHQIEKEMREL 910
+ F+R + A E ++ + QL + KQ+ + +A K ++E ++++L
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK--KLEGDLKDL 1636
Query: 911 LEETCKNKKTMEAKIKQL 928
+ K E IKQL
Sbjct: 1637 ELQADSAIKGREEAIKQL 1654
Score = 104 bits (259), Expect = 4e-22
Identities = 136/560 (24%), Positives = 256/560 (45%), Gaps = 70/560 (12%)
Query: 398 VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVE 457
+ V + + E++ EL K K++Q+ L+ LE+ ++ +K Q +L E E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE---QLQAETE 908
Query: 458 LKASAADREIYLLRTSLHREREQAQQLHQLLA-LKEQEHRKELETREFFTDA----DFQD 512
L A A + + L +++E + LH++ A L+E+E R + E A D ++
Sbjct: 909 LYAEAEEMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 513 ALAKEIAKEEKKH------EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKD 566
L +E A +K E IK+ +++I V+ Q L E ++ +E R + D
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEER----ISD 1017
Query: 567 GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AAN 623
N+A E K+K+ + +N+ S+I +L +K+++ E+ KLK++ A++
Sbjct: 1018 LTTNLAEEEEKAKNLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 624 LQNQINTLEILIEDDK-QKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGH--EL 680
QI L+ I + K Q + + E L+ +L E+A K + L+ R++ GH +L
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN---ALKKIRELEGHISDL 1130
Query: 681 AQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCL 740
+ S R K E Q L E E L+ E D+ + ++ + + + LK L
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 741 QEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVEL 800
DE + + ++ E+ + + ++E L E LE+ +R +K KQ L+ + +L
Sbjct: 1191 ---DEETRSHEAQVQEMRQKHAQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADL 1243
Query: 801 E-EIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 859
E+R H K +L E QV+E++ K + E+ DK +LQ N +E
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKL----EAQVQELQSKCSDGERARAELNDKVHKLQ-NEVES 1298
Query: 860 LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKK 919
+ M + + + + + ++A L+++ Q + +ELL+E + K
Sbjct: 1299 VTGMLNEAEGKAIKLAK----DVASLSSQLQ---------------DTQELLQEETRQKL 1339
Query: 920 TMEAKIKQLAFALNEIQQDM 939
+ K++QL N +Q +
Sbjct: 1340 NVSTKLRQLEEERNSLQDQL 1359
Score = 103 bits (257), Expect = 8e-22
Identities = 155/730 (21%), Positives = 310/730 (42%), Gaps = 121/730 (16%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKL----MDYIDELHK 363
+E+ + ++ ++ Q H++ + L EQL+Q + + ++ + L D EL
Sbjct: 1192 EETRSHEAQVQEMRQKHAQ--AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 364 HANEKEDIHSLALLTTDRLKEIIFR---ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 420
K+++ +++E+ + ++ +L VHKLQNE++ +T L +A+ +
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 421 QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 480
K + +L L+ + Q+ Q+ + +L V K + E L+ L E E
Sbjct: 1310 AIKLAKDVASLSSQLQ--DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 481 AQQLHQ---LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID 537
Q L + L ++ + +K+L+ +F A +AL + + +K+ E + ++Y+EK
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQ--DF---ASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 538 V--------------LSQQYMDLENEFRIALTVEA--RRFQDVKDGFENVATELAKSK-H 580
L +DL+N+ ++ +E R+F + +N++++ A +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 581 ALIWAQRKENESSSLIKDL--TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDD 638
A A+ KE ++ SL + L KE+ + ++ K + E + ++ + +E
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 639 KQK-SIQIELLKHEKVQLISELAAKESLIFGLRTERKV----WGHELAQQGSSLAQNRGK 693
K+ Q+E +K + +L EL A E L + + +L + + R +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 694 LEAQIESLSRENECLRKTN-------------------ESDS------DALRIKCKIIDD 728
L+ Q+ E E RK ++DS +A++ K+
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 729 QTETIRKLKDCLQEKDE-----------------HIKRLQEKITEIEKCTQEQLDEKSSQ 771
+ R+L+D +DE + +LQE + E+ ++ EK
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 772 LDEVLEKLERHN---ERKEKLKQQLKGKEVELEEIR---KAYSTLNRKWHDKGELLCHLE 825
+E+ L N + K +L+ ++ E ELEE + +A S RK + E L +
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 826 TQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQL 885
+ +K E+ ++L+ + K KLH M+ A K + + + A +A+IAQL
Sbjct: 1781 ATERSTAQKNESARQQLERQN-------KELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 886 -------ANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTME----------AKIKQL 928
A EKQ +A + Q +K+++E+L + +K E A++KQL
Sbjct: 1834 EEQVEQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889
Query: 929 AFALNEIQQD 938
L E +++
Sbjct: 1890 KRQLEEAEEE 1899
Score = 96.3 bits (238), Expect = 1e-19
Identities = 141/670 (21%), Positives = 285/670 (42%), Gaps = 84/670 (12%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLV-EQLDQEREKRWRAEQAENKLMDYIDELHKHAN 366
+ +K + E+ +++Q HS+ ++L+ EQL E E AE+ +L EL
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL----- 927
Query: 367 EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 426
+E +H + E E +GQ +LQ E KK+ +++ ++Q E+
Sbjct: 928 -EEILHEM---------EARLEEEEDRGQ------QLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 427 HLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADRE-----IYLLRTSLHREREQA 481
+ L+ LEK+ + + ++ L+ + + + +R+ I L T+L E E+A
Sbjct: 972 ARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 482 QQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ 541
+ L + L K + ELE R ++ +E+ K ++K E ++ E+I L
Sbjct: 1030 KNLTK-LKNKHESMISELEVR-----LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 542 QYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTC 601
Q +L+ + A++ ++++ + E+A+ +AL + E S L +DL
Sbjct: 1084 QIAELKMQL-------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 602 ------MVKEQKTKLAE--------------VSKLKQETAANLQNQINTL-EILIEDDKQ 640
++QK L E + +QE A + ++ L + L E+ +
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 641 KSIQIELLKHEKVQLISELA--------AKESLIFGLRTERKVWG------HELAQQGSS 686
Q++ ++ + Q + EL AK +L +T K L Q
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 687 LAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEH 746
+ + KLEAQ++ L +++C E L K + ++ E++ + + + K
Sbjct: 1257 VEHKKKKLEAQVQEL--QSKC--SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 747 IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 806
+ + ++ + TQE L E++ Q V KL + E + L+ QL + + + +
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 807 YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 866
STLN + D + L + V+ ++E + +K+++ + E + A +KL +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKNR 1431
Query: 867 FKRQVDAIVE--AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 924
++++D +V +Q ++ +KQ+ D + I + + + + E K
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
Query: 925 IKQLAFALNE 934
LA AL E
Sbjct: 1492 ALSLARALEE 1501
Score = 84.0 bits (206), Expect = 6e-16
Identities = 134/627 (21%), Positives = 269/627 (42%), Gaps = 82/627 (13%)
Query: 306 MLQESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQ-----------AENK 353
+LQE + K + K+ Q E N SL +QLD+E E + E+ ++ K
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 354 LMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVE 413
L D+ + K+ T + +E + + +LE ++LQ E+ L V+
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEE----KAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 414 LMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS 473
L ++ + + LEK K ++ +++ + E + +A A RE S
Sbjct: 1443 L-------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD-RAEAEAREKETKALS 1494
Query: 474 LHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQ 533
L R E+A + + L + + E+E + + D E+ K ++ E ++E +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 534 EKIDVLSQQYMDLEN-EFRIALTVEARRFQDVKD-----------------GFENVATEL 575
+++ L + E+ + R+ + ++A + Q +D TEL
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 576 A--KSKHALIWAQRKENESSSLIKDLTCM----VKEQKTKLAEVSKLK---QETAANLQN 626
+ + AL A +K+ E +KDL +K ++ + ++ KL+ ++ L++
Sbjct: 1613 EDERKQRALAAAAKKKLEGD--LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 627 QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGS- 685
+ + + K+ + + L+ + +QL +LAA E E++ ELA S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 686 --SLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDD-------QTETIRKL 736
+L + +LEA+I L E E + E+ SD +R + + + T +K
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 737 KDCLQEKDEHIKRLQEKITEIE-------KCTQEQLDEKSSQLDEVLEKLERHNERKEK- 788
+ Q+ + K L+ K+ E+E K T L+ K +QL+E +E+ R + K
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 789 LKQQ---LKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFEN---KEKKL 842
LKQ+ LK +++E+ RK + + L+ Q++E +E+ + +KL
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910
Query: 843 KAERDKSIELQKNAMEKLHSMDDAFKR 869
+ E D++ E + +++++ +R
Sbjct: 1911 QRELDEATESNEAMGREVNALKSKLRR 1937
Score = 81.3 bits (199), Expect = 4e-15
Identities = 96/457 (21%), Positives = 203/457 (44%), Gaps = 61/457 (13%)
Query: 487 LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE---YQEKIDVLSQQY 543
LL + QE + + E + Q E+ + E+KH Q+ +E QE++ ++ Y
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 544 MDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 603
+ E E R+ L + + +++ E E + + + A+RK+ L DL +
Sbjct: 911 AEAE-EMRVRLAAKKQELEEILHEME-ARLEEEEDRGQQLQAERKKMAQQML--DLEEQL 966
Query: 604 KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIE--LLKHEKVQLISELAA 661
+E++ ++ K A ++ + EIL+ DD+ + E LL+ L + LA
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLED--EILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 662 KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC-LRKTNESDSDALR 720
+E A+N KL+ + ES+ E E L+K +S + +
Sbjct: 1025 EE----------------------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062
Query: 721 IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE 780
+K K+ D ++ ++ D LQ + +K K E + +LD++ +Q + L+K+
Sbjct: 1063 LKRKLEGDASDFHEQIAD-LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI- 1120
Query: 781 RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 840
+L+ + + +L+ R A + ++ D GE L L+T++++ + ++
Sbjct: 1121 ------RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQ 1173
Query: 841 KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 900
+L+A+R++ + + K A+ D +H+A++ ++ + + ++ ++
Sbjct: 1174 ELRAKREQEVTVLKKAL--------------DEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 901 HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 937
Q ++ L KNK+T+E + LA L + Q
Sbjct: 1220 EQFKRAKANL----DKNKQTLEKENADLAGELRVLGQ 1252
Score = 75.1 bits (183), Expect = 3e-13
Identities = 138/648 (21%), Positives = 280/648 (43%), Gaps = 83/648 (12%)
Query: 198 LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 257
LQ E + + L+ L E NS+ + L+++ K++ + S + ++K
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSDSKK---- 1385
Query: 258 SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEI 317
K+ A T++ ++ K + + L + Y + A + EK K +
Sbjct: 1386 -KLQDFASTVEALEEGKKRFQKEIE--------NLTQQYEEKAAA----YDKLEKTKNRL 1432
Query: 318 IK-VDQSHSEDNTYQSLVEQLDQEREK--RWRAEQAE--NKLMDYIDELHKHANEKED-I 371
+ +D + + + LV L++++ K + AE+ +K D D A EKE
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 372 HSLALLTTDRLKEIIFRERNSK---GQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHL 428
SLA + L+ ER +K ++E +V ++++ K EL K+K E ++ +
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEM 1551
Query: 429 RTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL 488
+T LE++E + + + A++RL EV ++A E L EQ ++ + L
Sbjct: 1552 KT---QLEELEDELQATEDAKLRL--EVNMQALKGQFE-----RDLQARDEQNEEKRRQL 1601
Query: 489 ALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLEN 548
+ E+ ELE D Q ALA A +KK E +K+ + + D + +
Sbjct: 1602 QRQLHEYETELE------DERKQRALA---AAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 549 EFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKT 608
+ R L + + FQ E A++ I+A KENE + + M ++
Sbjct: 1653 QLR-KLQAQMKDFQR--------ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 609 KLAEVSKL-----KQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 663
AE ++ K+E A L + ++ L ++ ++ +I L+ E + + A
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 664 SLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR-KTNESDSD----- 717
+ + + +ELA + S+ +N E+ + L R+N+ LR K +E +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKN----ESARQQLERQNKELRSKLHEMEGAVKSKF 1819
Query: 718 -----ALRIKCKIIDDQTETIRKLKDC----LQEKDEHIKRLQEKITEIEKCTQ---EQL 765
AL K +++Q E + K L++KD+ +K + ++ + K + EQ
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879
Query: 766 DEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 813
++ ++++ ++ +LE E +++ + + EL+E ++ + R+
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/200 (24%), Positives = 99/200 (49%), Gaps = 8/200 (4%)
Query: 735 KLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLK 794
K+K LQ + + +Q K E++K T+E+ + ++L E+ +K + E K L++QL+
Sbjct: 847 KVKPLLQVTRQE-EEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 904
Query: 795 GKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQK 854
+ E + L K + E+L +E +++E E++ ++L+AER K +
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRGQQLQAERKKMAQQML 960
Query: 855 NAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEET 914
+ E+L ++A ++++ +A+I +L +E +D N K+ + K + E + +
Sbjct: 961 DLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERISDL 1018
Query: 915 CKNKKTMEAKIKQLAFALNE 934
N E K K L N+
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNK 1038
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 108 bits (270), Expect = 2e-23
Identities = 161/798 (20%), Positives = 335/798 (41%), Gaps = 97/798 (12%)
Query: 190 EKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKE 249
EKN + LQ E +L +++ L ++ +L + + + E D G + +
Sbjct: 895 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE-----MEARLEEEEDRGQQLQ 949
Query: 250 CNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQE 309
RK + + + + + K V+ K+K L++ + N + +E
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--LEDEILVMDDQNNKLSKE 1007
Query: 310 SEKPKTEIIKVDQSHSED-----------NTYQSLVEQLDQEREKRWRAEQAENKLMDYI 358
+ + I + + +E+ N ++S++ +L+ +K ++ Q KL
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK--- 1064
Query: 359 DELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAK 418
K + D H ++ E+ + + +L+ + +L +EI
Sbjct: 1065 ---RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---------- 1111
Query: 419 DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER 478
Q+ + LK +R LE + ++ ++AA+ + E + E+ L+T L
Sbjct: 1112 -QKNNALKKIRELEGHISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTL 1166
Query: 479 EQAQQLHQLLALKEQEH---RKELETREFFTDADFQDALAKEIAKEEKKHEQM--IKEYQ 533
+ +L A +EQE +K L+ +A Q+ K E+ EQ+ K +
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 534 EKID----VLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATEL----AKSKHALIWA 585
+D L ++ DL E R+ L + + K E EL + + A
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1285
Query: 586 QRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK---S 642
K ++ + ++ +T M+ E + K +++K ++ LQ+ T E+L E+ +QK S
Sbjct: 1286 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQKLNVS 1342
Query: 643 IQIELLKHEKV----QLISELAAKESLIFGLRT------ERKVWGHELAQQGSSLAQNRG 692
++ L+ E+ QL E+ AK++L + T + K + A +L + +
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402
Query: 693 KLEAQIESLSRENE-------CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDE 745
+ + +IE+L+++ E L KT L +D+Q + + L+ ++ D+
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 746 HI---KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEE 802
+ K + K + + + EK ++ + LE E KE+L++ K + E+E+
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1522
Query: 803 IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHS 862
+ + + + H+ + LETQ++E+K + E E +L+A D + L+ N + +
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN----MQA 1578
Query: 863 MDDAFKRQVDAIVEAHQAEIAQLANE------------KQKCIDSANLKVHQIEKEMREL 910
+ F+R + A E ++ + QL + KQ+ + +A K ++E ++++L
Sbjct: 1579 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK--KLEGDLKDL 1636
Query: 911 LEETCKNKKTMEAKIKQL 928
+ K E IKQL
Sbjct: 1637 ELQADSAIKGREEAIKQL 1654
Score = 104 bits (259), Expect = 4e-22
Identities = 136/560 (24%), Positives = 256/560 (45%), Gaps = 70/560 (12%)
Query: 398 VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVE 457
+ V + + E++ EL K K++Q+ L+ LE+ ++ +K Q +L E E
Sbjct: 852 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE---QLQAETE 908
Query: 458 LKASAADREIYLLRTSLHREREQAQQLHQLLA-LKEQEHRKELETREFFTDA----DFQD 512
L A A + + L +++E + LH++ A L+E+E R + E A D ++
Sbjct: 909 LYAEAEEMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 513 ALAKEIAKEEKKH------EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKD 566
L +E A +K E IK+ +++I V+ Q L E ++ +E R + D
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEER----ISD 1017
Query: 567 GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AAN 623
N+A E K+K+ + +N+ S+I +L +K+++ E+ KLK++ A++
Sbjct: 1018 LTTNLAEEEEKAKNLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 624 LQNQINTLEILIEDDK-QKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGH--EL 680
QI L+ I + K Q + + E L+ +L E+A K + L+ R++ GH +L
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN---ALKKIRELEGHISDL 1130
Query: 681 AQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCL 740
+ S R K E Q L E E L+ E D+ + ++ + + + LK L
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1190
Query: 741 QEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVEL 800
DE + + ++ E+ + + ++E L E LE+ +R +K KQ L+ + +L
Sbjct: 1191 ---DEETRSHEAQVQEMRQKHAQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADL 1243
Query: 801 E-EIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 859
E+R H K +L E QV+E++ K + E+ DK +LQ N +E
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKL----EAQVQELQSKCSDGERARAELNDKVHKLQ-NEVES 1298
Query: 860 LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKK 919
+ M + + + + + ++A L+++ Q + +ELL+E + K
Sbjct: 1299 VTGMLNEAEGKAIKLAK----DVASLSSQLQ---------------DTQELLQEETRQKL 1339
Query: 920 TMEAKIKQLAFALNEIQQDM 939
+ K++QL N +Q +
Sbjct: 1340 NVSTKLRQLEEERNSLQDQL 1359
Score = 103 bits (257), Expect = 8e-22
Identities = 155/730 (21%), Positives = 310/730 (42%), Gaps = 121/730 (16%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKL----MDYIDELHK 363
+E+ + ++ ++ Q H++ + L EQL+Q + + ++ + L D EL
Sbjct: 1192 EETRSHEAQVQEMRQKHAQ--AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 364 HANEKEDIHSLALLTTDRLKEIIFR---ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 420
K+++ +++E+ + ++ +L VHKLQNE++ +T L +A+ +
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 421 QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 480
K + +L L+ + Q+ Q+ + +L V K + E L+ L E E
Sbjct: 1310 AIKLAKDVASLSSQLQ--DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 481 AQQLHQ---LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID 537
Q L + L ++ + +K+L+ +F A +AL + + +K+ E + ++Y+EK
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQ--DF---ASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420
Query: 538 V--------------LSQQYMDLENEFRIALTVEA--RRFQDVKDGFENVATELAKSK-H 580
L +DL+N+ ++ +E R+F + +N++++ A +
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 581 ALIWAQRKENESSSLIKDL--TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDD 638
A A+ KE ++ SL + L KE+ + ++ K + E + ++ + +E
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 639 KQK-SIQIELLKHEKVQLISELAAKESLIFGLRTERKV----WGHELAQQGSSLAQNRGK 693
K+ Q+E +K + +L EL A E L + + +L + + R +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 694 LEAQIESLSRENECLRKTN-------------------ESDS------DALRIKCKIIDD 728
L+ Q+ E E RK ++DS +A++ K+
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1660
Query: 729 QTETIRKLKDCLQEKDE-----------------HIKRLQEKITEIEKCTQEQLDEKSSQ 771
+ R+L+D +DE + +LQE + E+ ++ EK
Sbjct: 1661 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1720
Query: 772 LDEVLEKLERHN---ERKEKLKQQLKGKEVELEEIR---KAYSTLNRKWHDKGELLCHLE 825
+E+ L N + K +L+ ++ E ELEE + +A S RK + E L +
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 826 TQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQL 885
+ +K E+ ++L+ + K KLH M+ A K + + + A +A+IAQL
Sbjct: 1781 ATERSTAQKNESARQQLERQN-------KELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 886 -------ANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTME----------AKIKQL 928
A EKQ +A + Q +K+++E+L + +K E A++KQL
Sbjct: 1834 EEQVEQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889
Query: 929 AFALNEIQQD 938
L E +++
Sbjct: 1890 KRQLEEAEEE 1899
Score = 96.3 bits (238), Expect = 1e-19
Identities = 141/670 (21%), Positives = 285/670 (42%), Gaps = 84/670 (12%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLV-EQLDQEREKRWRAEQAENKLMDYIDELHKHAN 366
+ +K + E+ +++Q HS+ ++L+ EQL E E AE+ +L EL
Sbjct: 873 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL----- 927
Query: 367 EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 426
+E +H + E E +GQ +LQ E KK+ +++ ++Q E+
Sbjct: 928 -EEILHEM---------EARLEEEEDRGQ------QLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 427 HLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADRE-----IYLLRTSLHREREQA 481
+ L+ LEK+ + + ++ L+ + + + +R+ I L T+L E E+A
Sbjct: 972 ARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 482 QQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ 541
+ L + L K + ELE R ++ +E+ K ++K E ++ E+I L
Sbjct: 1030 KNLTK-LKNKHESMISELEVR-----LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 542 QYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTC 601
Q +L+ + A++ ++++ + E+A+ +AL + E S L +DL
Sbjct: 1084 QIAELKMQL-------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1136
Query: 602 ------MVKEQKTKLAE--------------VSKLKQETAANLQNQINTL-EILIEDDKQ 640
++QK L E + +QE A + ++ L + L E+ +
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 641 KSIQIELLKHEKVQLISELA--------AKESLIFGLRTERKVWG------HELAQQGSS 686
Q++ ++ + Q + EL AK +L +T K L Q
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 687 LAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEH 746
+ + KLEAQ++ L +++C E L K + ++ E++ + + + K
Sbjct: 1257 VEHKKKKLEAQVQEL--QSKC--SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1312
Query: 747 IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 806
+ + ++ + TQE L E++ Q V KL + E + L+ QL + + + +
Sbjct: 1313 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1372
Query: 807 YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 866
STLN + D + L + V+ ++E + +K+++ + E + A +KL +
Sbjct: 1373 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKNR 1431
Query: 867 FKRQVDAIVE--AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 924
++++D +V +Q ++ +KQ+ D + I + + + + E K
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
Query: 925 IKQLAFALNE 934
LA AL E
Sbjct: 1492 ALSLARALEE 1501
Score = 82.4 bits (202), Expect = 2e-15
Identities = 133/609 (21%), Positives = 261/609 (42%), Gaps = 82/609 (13%)
Query: 306 MLQESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQ-----------AENK 353
+LQE + K + K+ Q E N SL +QLD+E E + E+ ++ K
Sbjct: 1330 LLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386
Query: 354 LMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVE 413
L D+ + K+ T + +E + + +LE ++LQ E+ L V+
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEE----KAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 414 LMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS 473
L ++ + + LEK K ++ +++ + E + +A A RE S
Sbjct: 1443 L-------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD-RAEAEAREKETKALS 1494
Query: 474 LHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQ 533
L R E+A + + L + + E+E + + D E+ K ++ E ++E +
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 534 EKIDVLSQQYMDLEN-EFRIALTVEARRFQDVKD-----------------GFENVATEL 575
+++ L + E+ + R+ + ++A + Q +D TEL
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 576 A--KSKHALIWAQRKENESSSLIKDLTCM----VKEQKTKLAEVSKLK---QETAANLQN 626
+ + AL A +K+ E +KDL +K ++ + ++ KL+ ++ L++
Sbjct: 1613 EDERKQRALAAAAKKKLEGD--LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 627 QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGS- 685
+ + + K+ + + L+ + +QL +LAA E E++ ELA S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 686 --SLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDD-------QTETIRKL 736
+L + +LEA+I L E E + E+ SD +R + + + T +K
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 737 KDCLQEKDEHIKRLQEKITEIE-------KCTQEQLDEKSSQLDEVLEKLERHNERKEK- 788
+ Q+ + K L+ K+ E+E K T L+ K +QL+E +E+ R + K
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 789 LKQQ---LKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFEN---KEKKL 842
LKQ+ LK +++E+ RK + + L+ Q++E +E+ + +KL
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910
Query: 843 KAERDKSIE 851
+ E D++ E
Sbjct: 1911 QRELDEATE 1919
Score = 81.3 bits (199), Expect = 4e-15
Identities = 96/457 (21%), Positives = 203/457 (44%), Gaps = 61/457 (13%)
Query: 487 LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE---YQEKIDVLSQQY 543
LL + QE + + E + Q E+ + E+KH Q+ +E QE++ ++ Y
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 544 MDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 603
+ E E R+ L + + +++ E E + + + A+RK+ L DL +
Sbjct: 911 AEAE-EMRVRLAAKKQELEEILHEME-ARLEEEEDRGQQLQAERKKMAQQML--DLEEQL 966
Query: 604 KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIE--LLKHEKVQLISELAA 661
+E++ ++ K A ++ + EIL+ DD+ + E LL+ L + LA
Sbjct: 967 EEEEAARQKLQLEKVTAEAKIKKLED--EILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 662 KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC-LRKTNESDSDALR 720
+E A+N KL+ + ES+ E E L+K +S + +
Sbjct: 1025 EE----------------------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1062
Query: 721 IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE 780
+K K+ D ++ ++ D LQ + +K K E + +LD++ +Q + L+K+
Sbjct: 1063 LKRKLEGDASDFHEQIAD-LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI- 1120
Query: 781 RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 840
+L+ + + +L+ R A + ++ D GE L L+T++++ + ++
Sbjct: 1121 ------RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQ 1173
Query: 841 KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 900
+L+A+R++ + + K A+ D +H+A++ ++ + + ++ ++
Sbjct: 1174 ELRAKREQEVTVLKKAL--------------DEETRSHEAQVQEMRQKHAQAVEELTEQL 1219
Query: 901 HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 937
Q ++ L KNK+T+E + LA L + Q
Sbjct: 1220 EQFKRAKANL----DKNKQTLEKENADLAGELRVLGQ 1252
Score = 75.1 bits (183), Expect = 3e-13
Identities = 138/648 (21%), Positives = 280/648 (43%), Gaps = 83/648 (12%)
Query: 198 LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 257
LQ E + + L+ L E NS+ + L+++ K++ + S + ++K
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSDSKK---- 1385
Query: 258 SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEI 317
K+ A T++ ++ K + + L + Y + A + EK K +
Sbjct: 1386 -KLQDFASTVEALEEGKKRFQKEIE--------NLTQQYEEKAAA----YDKLEKTKNRL 1432
Query: 318 IK-VDQSHSEDNTYQSLVEQLDQEREK--RWRAEQAE--NKLMDYIDELHKHANEKED-I 371
+ +D + + + LV L++++ K + AE+ +K D D A EKE
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1492
Query: 372 HSLALLTTDRLKEIIFRERNSK---GQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHL 428
SLA + L+ ER +K ++E +V ++++ K EL K+K E ++ +
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEM 1551
Query: 429 RTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL 488
+T LE++E + + + A++RL EV ++A E L EQ ++ + L
Sbjct: 1552 KT---QLEELEDELQATEDAKLRL--EVNMQALKGQFE-----RDLQARDEQNEEKRRQL 1601
Query: 489 ALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLEN 548
+ E+ ELE D Q ALA A +KK E +K+ + + D + +
Sbjct: 1602 QRQLHEYETELE------DERKQRALA---AAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 549 EFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKT 608
+ R L + + FQ E A++ I+A KENE + + M ++
Sbjct: 1653 QLR-KLQAQMKDFQR--------ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 609 KLAEVSKL-----KQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 663
AE ++ K+E A L + ++ L ++ ++ +I L+ E + + A
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 664 SLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR-KTNESDSD----- 717
+ + + +ELA + S+ +N E+ + L R+N+ LR K +E +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKN----ESARQQLERQNKELRSKLHEMEGAVKSKF 1819
Query: 718 -----ALRIKCKIIDDQTETIRKLKDC----LQEKDEHIKRLQEKITEIEKCTQ---EQL 765
AL K +++Q E + K L++KD+ +K + ++ + K + EQ
Sbjct: 1820 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1879
Query: 766 DEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 813
++ ++++ ++ +LE E +++ + + EL+E ++ + R+
Sbjct: 1880 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/200 (24%), Positives = 99/200 (49%), Gaps = 8/200 (4%)
Query: 735 KLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLK 794
K+K LQ + + +Q K E++K T+E+ + ++L E+ +K + E K L++QL+
Sbjct: 847 KVKPLLQVTRQE-EEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 904
Query: 795 GKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQK 854
+ E + L K + E+L +E +++E E++ ++L+AER K +
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRGQQLQAERKKMAQQML 960
Query: 855 NAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEET 914
+ E+L ++A ++++ +A+I +L +E +D N K+ + K + E + +
Sbjct: 961 DLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERISDL 1018
Query: 915 CKNKKTMEAKIKQLAFALNE 934
N E K K L N+
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNK 1038
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 108 bits (270), Expect = 2e-23
Identities = 161/798 (20%), Positives = 335/798 (41%), Gaps = 97/798 (12%)
Query: 190 EKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKE 249
EKN + LQ E +L +++ L ++ +L + + + E D G + +
Sbjct: 888 EKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHE-----MEARLEEEEDRGQQLQ 942
Query: 250 CNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQE 309
RK + + + + + K V+ K+K L++ + N + +E
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKK--LEDEILVMDDQNNKLSKE 1000
Query: 310 SEKPKTEIIKVDQSHSED-----------NTYQSLVEQLDQEREKRWRAEQAENKLMDYI 358
+ + I + + +E+ N ++S++ +L+ +K ++ Q KL
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK--- 1057
Query: 359 DELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAK 418
K + D H ++ E+ + + +L+ + +L +EI
Sbjct: 1058 ---RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---------- 1104
Query: 419 DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER 478
Q+ + LK +R LE + ++ ++AA+ + E + E+ L+T L
Sbjct: 1105 -QKNNALKKIRELEGHISDLQEDLDSERAAR----NKAEKQKRDLGEELEALKTELEDTL 1159
Query: 479 EQAQQLHQLLALKEQEH---RKELETREFFTDADFQDALAKEIAKEEKKHEQM--IKEYQ 533
+ +L A +EQE +K L+ +A Q+ K E+ EQ+ K +
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 534 EKID----VLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATEL----AKSKHALIWA 585
+D L ++ DL E R+ L + + K E EL + + A
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRV-LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAEL 1278
Query: 586 QRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK---S 642
K ++ + ++ +T M+ E + K +++K ++ LQ+ T E+L E+ +QK S
Sbjct: 1279 NDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQKLNVS 1335
Query: 643 IQIELLKHEKV----QLISELAAKESLIFGLRT------ERKVWGHELAQQGSSLAQNRG 692
++ L+ E+ QL E+ AK++L + T + K + A +L + +
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395
Query: 693 KLEAQIESLSRENE-------CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDE 745
+ + +IE+L+++ E L KT L +D+Q + + L+ ++ D+
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 746 HI---KRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEE 802
+ K + K + + + EK ++ + LE E KE+L++ K + E+E+
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMED 1515
Query: 803 IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHS 862
+ + + + H+ + LETQ++E+K + E E +L+A D + L+ N + +
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN----MQA 1571
Query: 863 MDDAFKRQVDAIVEAHQAEIAQLANE------------KQKCIDSANLKVHQIEKEMREL 910
+ F+R + A E ++ + QL + KQ+ + +A K ++E ++++L
Sbjct: 1572 LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK--KLEGDLKDL 1629
Query: 911 LEETCKNKKTMEAKIKQL 928
+ K E IKQL
Sbjct: 1630 ELQADSAIKGREEAIKQL 1647
Score = 104 bits (259), Expect = 4e-22
Identities = 136/560 (24%), Positives = 256/560 (45%), Gaps = 70/560 (12%)
Query: 398 VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVE 457
+ V + + E++ EL K K++Q+ L+ LE+ ++ +K Q +L E E
Sbjct: 845 LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE---QLQAETE 901
Query: 458 LKASAADREIYLLRTSLHREREQAQQLHQLLA-LKEQEHRKELETREFFTDA----DFQD 512
L A A + + L +++E + LH++ A L+E+E R + E A D ++
Sbjct: 902 LYAEAEEMRVRLAA----KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 513 ALAKEIAKEEKKH------EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKD 566
L +E A +K E IK+ +++I V+ Q L E ++ +E R + D
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEER----ISD 1010
Query: 567 GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AAN 623
N+A E K+K+ + +N+ S+I +L +K+++ E+ KLK++ A++
Sbjct: 1011 LTTNLAEEEEKAKNLT----KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 624 LQNQINTLEILIEDDK-QKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGH--EL 680
QI L+ I + K Q + + E L+ +L E+A K + L+ R++ GH +L
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN---ALKKIRELEGHISDL 1123
Query: 681 AQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCL 740
+ S R K E Q L E E L+ E D+ + ++ + + + LK L
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKAL 1183
Query: 741 QEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVEL 800
DE + + ++ E+ + + ++E L E LE+ +R +K KQ L+ + +L
Sbjct: 1184 ---DEETRSHEAQVQEMRQKHAQAVEE----LTEQLEQFKRAKANLDKNKQTLEKENADL 1236
Query: 801 E-EIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 859
E+R H K +L E QV+E++ K + E+ DK +LQ N +E
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKL----EAQVQELQSKCSDGERARAELNDKVHKLQ-NEVES 1291
Query: 860 LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKK 919
+ M + + + + + ++A L+++ Q + +ELL+E + K
Sbjct: 1292 VTGMLNEAEGKAIKLAK----DVASLSSQLQ---------------DTQELLQEETRQKL 1332
Query: 920 TMEAKIKQLAFALNEIQQDM 939
+ K++QL N +Q +
Sbjct: 1333 NVSTKLRQLEEERNSLQDQL 1352
Score = 103 bits (257), Expect = 8e-22
Identities = 155/730 (21%), Positives = 310/730 (42%), Gaps = 121/730 (16%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKL----MDYIDELHK 363
+E+ + ++ ++ Q H++ + L EQL+Q + + ++ + L D EL
Sbjct: 1185 EETRSHEAQVQEMRQKHAQ--AVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 364 HANEKEDIHSLALLTTDRLKEIIFR---ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 420
K+++ +++E+ + ++ +L VHKLQNE++ +T L +A+ +
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 421 QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 480
K + +L L+ + Q+ Q+ + +L V K + E L+ L E E
Sbjct: 1303 AIKLAKDVASLSSQLQ--DTQELLQEETRQKL--NVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 481 AQQLHQ---LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID 537
Q L + L ++ + +K+L+ +F A +AL + + +K+ E + ++Y+EK
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQ--DF---ASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413
Query: 538 V--------------LSQQYMDLENEFRIALTVEA--RRFQDVKDGFENVATELAKSK-H 580
L +DL+N+ ++ +E R+F + +N++++ A +
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 581 ALIWAQRKENESSSLIKDL--TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDD 638
A A+ KE ++ SL + L KE+ + ++ K + E + ++ + +E
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 639 KQK-SIQIELLKHEKVQLISELAAKESLIFGLRTERKV----WGHELAQQGSSLAQNRGK 693
K+ Q+E +K + +L EL A E L + + +L + + R +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 694 LEAQIESLSRENECLRKTN-------------------ESDS------DALRIKCKIIDD 728
L+ Q+ E E RK ++DS +A++ K+
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ 1653
Query: 729 QTETIRKLKDCLQEKDE-----------------HIKRLQEKITEIEKCTQEQLDEKSSQ 771
+ R+L+D +DE + +LQE + E+ ++ EK
Sbjct: 1654 MKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEEL 1713
Query: 772 LDEVLEKLERHN---ERKEKLKQQLKGKEVELEEIR---KAYSTLNRKWHDKGELLCHLE 825
+E+ L N + K +L+ ++ E ELEE + +A S RK + E L +
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 826 TQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQL 885
+ +K E+ ++L+ + K KLH M+ A K + + + A +A+IAQL
Sbjct: 1774 ATERSTAQKNESARQQLERQN-------KELRSKLHEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 886 -------ANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTME----------AKIKQL 928
A EKQ +A + Q +K+++E+L + +K E A++KQL
Sbjct: 1827 EEQVEQEAREKQ----AATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882
Query: 929 AFALNEIQQD 938
L E +++
Sbjct: 1883 KRQLEEAEEE 1892
Score = 96.3 bits (238), Expect = 1e-19
Identities = 141/670 (21%), Positives = 285/670 (42%), Gaps = 84/670 (12%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLV-EQLDQEREKRWRAEQAENKLMDYIDELHKHAN 366
+ +K + E+ +++Q HS+ ++L+ EQL E E AE+ +L EL
Sbjct: 866 ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQEL----- 920
Query: 367 EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 426
+E +H + E E +GQ +LQ E KK+ +++ ++Q E+
Sbjct: 921 -EEILHEM---------EARLEEEEDRGQ------QLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 427 HLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADRE-----IYLLRTSLHREREQA 481
+ L+ LEK+ + + ++ L+ + + + +R+ I L T+L E E+A
Sbjct: 965 ARQKLQ--LEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 482 QQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQ 541
+ L + L K + ELE R ++ +E+ K ++K E ++ E+I L
Sbjct: 1023 KNLTK-LKNKHESMISELEVR-----LKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 542 QYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTC 601
Q +L+ + A++ ++++ + E+A+ +AL + E S L +DL
Sbjct: 1077 QIAELKMQL-------AKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDS 1129
Query: 602 ------MVKEQKTKLAE--------------VSKLKQETAANLQNQINTL-EILIEDDKQ 640
++QK L E + +QE A + ++ L + L E+ +
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 641 KSIQIELLKHEKVQLISELA--------AKESLIFGLRTERKVWG------HELAQQGSS 686
Q++ ++ + Q + EL AK +L +T K L Q
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 687 LAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEH 746
+ + KLEAQ++ L +++C E L K + ++ E++ + + + K
Sbjct: 1250 VEHKKKKLEAQVQEL--QSKC--SDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIK 1305
Query: 747 IKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 806
+ + ++ + TQE L E++ Q V KL + E + L+ QL + + + +
Sbjct: 1306 LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERH 1365
Query: 807 YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 866
STLN + D + L + V+ ++E + +K+++ + E + A +KL +
Sbjct: 1366 ISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIE-NLTQQYEEKAAAYDKLEKTKNR 1424
Query: 867 FKRQVDAIVE--AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 924
++++D +V +Q ++ +KQ+ D + I + + + + E K
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484
Query: 925 IKQLAFALNE 934
LA AL E
Sbjct: 1485 ALSLARALEE 1494
Score = 82.4 bits (202), Expect = 2e-15
Identities = 133/609 (21%), Positives = 261/609 (42%), Gaps = 82/609 (13%)
Query: 306 MLQESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQ-----------AENK 353
+LQE + K + K+ Q E N SL +QLD+E E + E+ ++ K
Sbjct: 1323 LLQEETRQKLNVSTKLRQLEEERN---SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379
Query: 354 LMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVE 413
L D+ + K+ T + +E + + +LE ++LQ E+ L V+
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEE----KAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 414 LMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS 473
L ++ + + LEK K ++ +++ + E + +A A RE S
Sbjct: 1436 L-------DNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD-RAEAEAREKETKALS 1487
Query: 474 LHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQ 533
L R E+A + + L + + E+E + + D E+ K ++ E ++E +
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEME--DLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 534 EKIDVLSQQYMDLEN-EFRIALTVEARRFQDVKD-----------------GFENVATEL 575
+++ L + E+ + R+ + ++A + Q +D TEL
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 576 A--KSKHALIWAQRKENESSSLIKDLTCM----VKEQKTKLAEVSKLK---QETAANLQN 626
+ + AL A +K+ E +KDL +K ++ + ++ KL+ ++ L++
Sbjct: 1606 EDERKQRALAAAAKKKLEGD--LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 627 QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGS- 685
+ + + K+ + + L+ + +QL +LAA E E++ ELA S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 686 --SLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDD-------QTETIRKL 736
+L + +LEA+I L E E + E+ SD +R + + + T +K
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 737 KDCLQEKDEHIKRLQEKITEIE-------KCTQEQLDEKSSQLDEVLEKLERHNERKEK- 788
+ Q+ + K L+ K+ E+E K T L+ K +QL+E +E+ R + K
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 789 LKQQ---LKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFEN---KEKKL 842
LKQ+ LK +++E+ RK + + L+ Q++E +E+ + +KL
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903
Query: 843 KAERDKSIE 851
+ E D++ E
Sbjct: 1904 QRELDEATE 1912
Score = 81.3 bits (199), Expect = 4e-15
Identities = 96/457 (21%), Positives = 203/457 (44%), Gaps = 61/457 (13%)
Query: 487 LLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE---YQEKIDVLSQQY 543
LL + QE + + E + Q E+ + E+KH Q+ +E QE++ ++ Y
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 544 MDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 603
+ E E R+ L + + +++ E E + + + A+RK+ L DL +
Sbjct: 904 AEAE-EMRVRLAAKKQELEEILHEME-ARLEEEEDRGQQLQAERKKMAQQML--DLEEQL 959
Query: 604 KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIE--LLKHEKVQLISELAA 661
+E++ ++ K A ++ + EIL+ DD+ + E LL+ L + LA
Sbjct: 960 EEEEAARQKLQLEKVTAEAKIKKLED--EILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 662 KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC-LRKTNESDSDALR 720
+E A+N KL+ + ES+ E E L+K +S + +
Sbjct: 1018 EE----------------------EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEK 1055
Query: 721 IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLE 780
+K K+ D ++ ++ D LQ + +K K E + +LD++ +Q + L+K+
Sbjct: 1056 LKRKLEGDASDFHEQIAD-LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI- 1113
Query: 781 RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 840
+L+ + + +L+ R A + ++ D GE L L+T++++ + ++
Sbjct: 1114 ------RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-QQ 1166
Query: 841 KLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 900
+L+A+R++ + + K A+ D +H+A++ ++ + + ++ ++
Sbjct: 1167 ELRAKREQEVTVLKKAL--------------DEETRSHEAQVQEMRQKHAQAVEELTEQL 1212
Query: 901 HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 937
Q ++ L KNK+T+E + LA L + Q
Sbjct: 1213 EQFKRAKANL----DKNKQTLEKENADLAGELRVLGQ 1245
Score = 75.1 bits (183), Expect = 3e-13
Identities = 138/648 (21%), Positives = 280/648 (43%), Gaps = 83/648 (12%)
Query: 198 LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 257
LQ E + + L+ L E NS+ + L+++ K++ + S + ++K
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE-RHISTLNIQLSDSKK---- 1378
Query: 258 SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEI 317
K+ A T++ ++ K + + L + Y + A + EK K +
Sbjct: 1379 -KLQDFASTVEALEEGKKRFQKEIE--------NLTQQYEEKAAA----YDKLEKTKNRL 1425
Query: 318 IK-VDQSHSEDNTYQSLVEQLDQEREK--RWRAEQAE--NKLMDYIDELHKHANEKED-I 371
+ +D + + + LV L++++ K + AE+ +K D D A EKE
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA 1485
Query: 372 HSLALLTTDRLKEIIFRERNSK---GQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHL 428
SLA + L+ ER +K ++E +V ++++ K EL K+K E ++ +
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSS-KDDVGKNVHELEKSKRALETQMEEM 1544
Query: 429 RTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL 488
+T LE++E + + + A++RL EV ++A E L EQ ++ + L
Sbjct: 1545 KT---QLEELEDELQATEDAKLRL--EVNMQALKGQFE-----RDLQARDEQNEEKRRQL 1594
Query: 489 ALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLEN 548
+ E+ ELE D Q ALA A +KK E +K+ + + D + +
Sbjct: 1595 QRQLHEYETELE------DERKQRALA---AAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 549 EFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKT 608
+ R L + + FQ E A++ I+A KENE + + M ++
Sbjct: 1646 QLR-KLQAQMKDFQR--------ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 609 KLAEVSKL-----KQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 663
AE ++ K+E A L + ++ L ++ ++ +I L+ E + + A
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 664 SLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR-KTNESDSD----- 717
+ + + +ELA + S+ +N E+ + L R+N+ LR K +E +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKN----ESARQQLERQNKELRSKLHEMEGAVKSKF 1812
Query: 718 -----ALRIKCKIIDDQTETIRKLKDC----LQEKDEHIKRLQEKITEIEKCTQ---EQL 765
AL K +++Q E + K L++KD+ +K + ++ + K + EQ
Sbjct: 1813 KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQA 1872
Query: 766 DEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 813
++ ++++ ++ +LE E +++ + + EL+E ++ + R+
Sbjct: 1873 EKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920
Score = 51.6 bits (122), Expect = 3e-06
Identities = 49/200 (24%), Positives = 99/200 (49%), Gaps = 8/200 (4%)
Query: 735 KLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLK 794
K+K LQ + + +Q K E++K T+E+ + ++L E+ +K + E K L++QL+
Sbjct: 840 KVKPLLQVTRQE-EEMQAKEDELQK-TKERQQKAENELKELEQKHSQLTEEKNLLQEQLQ 897
Query: 795 GKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQK 854
+ E + L K + E+L +E +++E E++ ++L+AER K +
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE----EDRGQQLQAERKKMAQQML 953
Query: 855 NAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEET 914
+ E+L ++A ++++ +A+I +L +E +D N K+ + K + E + +
Sbjct: 954 DLEEQLEE-EEAARQKLQLEKVTAEAKIKKLEDE-ILVMDDQNNKLSKERKLLEERISDL 1011
Query: 915 CKNKKTMEAKIKQLAFALNE 934
N E K K L N+
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNK 1031
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 108 bits (269), Expect = 3e-23
Identities = 166/813 (20%), Positives = 335/813 (41%), Gaps = 158/813 (19%)
Query: 247 RKECNRKVPRRSKI---PYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLAN 303
R E + + RR I Y+ + +KH ++ K+KP LK +AN
Sbjct: 802 RVEFRKMMERRESIFCIQYNIRAFMNVKHW-----PWMKLYFKIKP-LLKSAETEKEMAN 855
Query: 304 CPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHK 363
M +E EK K E+ K + E + +V + ++ + + + + + L D + +
Sbjct: 856 --MKEEFEKTKEELAKTEAKRKE--LEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQ 911
Query: 364 HANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLT-----VELMKAK 418
K + + T+R ++ E +L KL++E +L +EL AK
Sbjct: 912 LIKTKIQLEAKIKEVTERAED----EEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 419 DQQEDHL---------KHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA------ 463
++E H + + L++T+ K+ ++K+ Q A + + +++++
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKA 1027
Query: 464 ----DREIYLLRTSLHREREQAQQLHQLLA----------------------LKEQEHRK 497
++++ L SL +E++ L + L E+ +K
Sbjct: 1028 KTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKK 1087
Query: 498 ELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDV-------LSQQYMDLENEF 550
E E + + ALA ++ K+ K+ + I+E +E+I+ +Q DL E
Sbjct: 1088 EFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147
Query: 551 RIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCM-------- 602
E + G + E+ K + A R++ E S+L + T
Sbjct: 1148 E-----EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHAD 1202
Query: 603 ----VKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELL---------- 648
+ EQ L V + ++ + L+ +IN L +E + E +
Sbjct: 1203 SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSE 1262
Query: 649 ----KHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQ-NRGK--LEAQIESL 701
+ E+ +LI+EL+A+++ L TE + +L ++ + ++Q +RGK QIE L
Sbjct: 1263 IKTKEEEQQRLINELSAQKAR---LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEEL 1319
Query: 702 SRENECLRKTNESDSDAL---RIKCKIIDDQTETIRKLKDCLQE---------------- 742
R+ E K + + AL R C ++ +Q E ++ K LQ
Sbjct: 1320 KRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKY 1379
Query: 743 KDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEE 802
+ + I+R +E + E +K ++L + ++ V K + K++L+ +++ +++E
Sbjct: 1380 ETDAIQRTEE-LEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 803 IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQ------KNA 856
A L++K + ++L E K+K+E + +L+A + +S L KNA
Sbjct: 1439 SNAACIALDKKQRNFDKVLA-------EWKQKYEETQAELEASQKESRSLSTELFKVKNA 1491
Query: 857 MEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEK----------E 906
E+ + KR+ + Q EI+ L + I +H++EK E
Sbjct: 1492 YEESLDHLETLKRENKNL----QQEISDLTEQ----IAEGGKHIHELEKVKKQLDHEKSE 1543
Query: 907 MRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 939
++ LEE + + E KI ++ LN+++ ++
Sbjct: 1544 LQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Score = 81.6 bits (200), Expect = 3e-15
Identities = 135/630 (21%), Positives = 271/630 (43%), Gaps = 84/630 (13%)
Query: 294 ELYVSSSLANCPMLQESEKPKTEIIKVDQSHSEDNT-----YQSLVEQLDQEREKRWRAE 348
EL S AN + Q K +T+ I+ + E Q E ++ K E
Sbjct: 1360 ELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLE 1419
Query: 349 QAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSK-GQLEVMVHKLQNEI 407
+ + +L + +++L E+ + +AL R + + E K + + + Q E
Sbjct: 1420 KTKQRLQNEVEDLMIDV-ERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKES 1478
Query: 408 KKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ---KRQQQAAQIRLIQEVELKASAAD 464
+ L+ EL K K+ E+ L HL TL++ + ++++ +Q A + I E+E D
Sbjct: 1479 RSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLD 1538
Query: 465 REIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKK 524
E L+TSL E+A+ A E E K L + E+ + + +
Sbjct: 1539 HEKSELQTSL----EEAE------ASLEHEEGKILR-------------IQLELNQVKSE 1575
Query: 525 HEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIW 584
++ I E E++D L + ++ + + L E R D + + +L + + L
Sbjct: 1576 IDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNH 1635
Query: 585 AQRKENESSSLIKDLTCMVKEQKTKLAEVSKLK---QETAANLQNQINTLEILIEDDKQK 641
A R+ E+ +++ ++K+ + L + + + +E A ++ + N ++ +E+ +
Sbjct: 1636 ANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRAS 1695
Query: 642 SIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESL 701
E+ + ++A +E L R + L Q +SL + KLE I +
Sbjct: 1696 L--------ERTERGRKMAEQELLDASERVQL------LHTQNTSLINTKKKLETDISQI 1741
Query: 702 SRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCT 761
E E + + + + + K I D +LK Q+ H++R+++ + + K
Sbjct: 1742 QGEMEDIVQEARNAEEKAK---KAITDAAMMAEELKK-EQDTSAHLERMKKNMEQTVKDL 1797
Query: 762 QEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELL 821
Q +LDE + QL L+ ++ +KL+ +++ E E+E +K
Sbjct: 1798 QLRLDE-AEQL-----ALKGGKKQIQKLEARVRELESEVESEQK---------------- 1835
Query: 822 CHLETQVKEVKEKFENKEKKL--KAERD-KSIELQKNAMEKLHSMDDAFKRQVDAIVEAH 878
H VK ++ K E + K+L + E D K+I ++ ++KL + A+KRQ + E
Sbjct: 1836 -HNVEAVKGLR-KHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQS 1893
Query: 879 QAEIA---QLANEKQKCIDSANLKVHQIEK 905
+A +L +E ++ + A++ Q+ K
Sbjct: 1894 NVNLAKFRKLQHELEEAKERADIAESQVNK 1923
Score = 66.2 bits (160), Expect = 1e-10
Identities = 110/588 (18%), Positives = 254/588 (43%), Gaps = 52/588 (8%)
Query: 296 YVSSSLANCPMLQESEKPKTEIIKVDQSHSE---------DNTYQSL---VEQLDQEREK 343
Y + ++ L+E++K + ++ + H E + T Q L VE L + E+
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 344 RWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR----LKEIIFRERNSKGQLEVM 399
A A +K D++ +K + L + + L +F+ +N+ +
Sbjct: 1439 SNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDH 1498
Query: 400 VHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELK 459
+ L+ E K L E+ +Q + KH+ LEK ++++ +K + Q + ++E E
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTS----LEEAEAS 1554
Query: 460 ASAADREIYLLRTSLHR-----EREQAQQLHQLLALKEQEHRKELETREFFTDADFQDAL 514
+ +I ++ L++ +R+ A++ +L LK + H + +E+ + DA+ +
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLK-RNHLRVVESMQSTLDAEIRS-- 1611
Query: 515 AKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATE 574
+ + +KK E + E + +++ ++Q + R + +D + ++
Sbjct: 1612 RNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGI----LKDTQLHLDDAIRG 1667
Query: 575 LAKSKHALIWAQRKENESSSLIKDLTCMVK--EQKTKLAEVSKLKQETAANLQNQINTLE 632
K L +R+ N + +++L ++ E+ K+AE L L + NT
Sbjct: 1668 QDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNT-- 1725
Query: 633 ILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRG 692
LI K+ I ++ E ++ E E T+ + EL ++ + A
Sbjct: 1726 SLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH--- 1782
Query: 693 KLEAQIESLSRENECLR-KTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQ 751
LE +++ + + L+ + +E++ AL+ K I +R+L+ ++ + +H
Sbjct: 1783 -LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAV 1841
Query: 752 EKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLN 811
+ + + E+ ++ E + Q +E + + R + +KL+ ++K + + EE + +
Sbjct: 1842 KGLRKHER----RVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL 1897
Query: 812 RKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 859
K+ L+ +++E KE+ + E ++ R KS E+ + +
Sbjct: 1898 AKFR-------KLQHELEEAKERADIAESQVNKLRVKSREVHTKVISE 1938
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 105 bits (262), Expect = 2e-22
Identities = 163/776 (21%), Positives = 326/776 (42%), Gaps = 100/776 (12%)
Query: 199 QNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRS 258
++E K ++L+++++ LL E N L+ + + D+ +E + C + + +
Sbjct: 868 KSEAKRKELEEKMVTLLKEK-----NDLQLQVQSEADSLADAE------ERCEQLIKNKI 916
Query: 259 KIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEII 318
++ K + + N+ ++ ++ EL ++ + + +
Sbjct: 917 QLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELK-----------KDIDDLELTLA 965
Query: 319 KVD-QSHSEDNTYQSLVEQ---LDQEREKRWRAEQA-ENKLMDYIDELHKHANEKEDIHS 373
KV+ + H+ +N ++L E+ LD+ K + ++A + +D+L E++ ++
Sbjct: 966 KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQA---EEDKVNI 1022
Query: 374 LALLTT------DRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKH 427
L T D L+ + +E+ + LE KL+ ++K M ++ ++ +
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 428 LRTLEKTLEKMERQKRQQQAAQIRL---IQEVELKASAADREIYLLRTSLHREREQAQQL 484
L E + + + +QA +I+L I+E++ + EI R S + +Q L
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDL 1142
Query: 485 HQLL---------------ALKEQEHRKELETREFFTDADFQDALAKE--IAKEEKKHEQ 527
+ L A E ++E E ++ D + + L E +A KKH
Sbjct: 1143 SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLE-EATLQHEAMVAALRKKHAD 1201
Query: 528 MIKEYQEKIDVLSQQYMDLENEFRIA------LTVEARRFQDVKDGFENVATELAKSKHA 581
+ E E+ID L + LE E L+ A K E + L
Sbjct: 1202 SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSE 1261
Query: 582 LIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK 641
L + KE E LI DLT +T+ E S+ E A L +Q++ KQ
Sbjct: 1262 L---KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDA-LVSQLSR-------SKQA 1310
Query: 642 SIQ-IELLKHEKVQLISELAAKESLIFGLRTERKVWGHE---LAQQGSSLAQNRGKLEAQ 697
S Q IE LKH QL E AK +L L++ R H+ L +Q + GK E Q
Sbjct: 1311 STQQIEELKH---QLEEETKAKNALAHALQSSR----HDCDLLREQYEE--EQEGKAELQ 1361
Query: 698 IESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEI 757
+E + + ++DA++ ++ E +KL LQE +EH++ + K +
Sbjct: 1362 RALSKANSEVAQWRTKYETDAIQRT----EELEEAKKKLAQRLQEAEEHVEAVNAKCASL 1417
Query: 758 EKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDK 817
EK T+++L +++++++ +ER N L ++ + + L E ++ Y +
Sbjct: 1418 EK-TKQRL---QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEAS 1473
Query: 818 GELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKR-----QVD 872
+ L T++ +VK +E +L+ R ++ LQ+ + + + K+ ++
Sbjct: 1474 QKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIK 1533
Query: 873 AIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 928
VE + EI E + ++ K+ +I+ E+ ++ E + + +I QL
Sbjct: 1534 KQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQL 1589
Score = 96.3 bits (238), Expect = 1e-19
Identities = 124/552 (22%), Positives = 238/552 (43%), Gaps = 45/552 (8%)
Query: 404 QNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA 463
+ E+ + E K KD+ + LE EKM +++ Q+++ E + A A
Sbjct: 849 EKEMATMKEEFQKTKDELAKSEAKRKELE---EKMVTLLKEKNDLQLQVQSEADSLADAE 905
Query: 464 DREIYLLRTSLHRER------EQAQQLHQLLA-LKEQEHRKELETREFFTDADFQDALAK 516
+R L++ + E E+A++ ++ A L ++ + E E E D D +
Sbjct: 906 ERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 965
Query: 517 EIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELA 576
++ KE+ E +K E++ L + L E + + D++ E+ L
Sbjct: 966 KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQ-AEEDKVNILT 1024
Query: 577 KSKHALIWAQRKENESSSLI--KDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEIL 634
K+K L Q+ ++ SL K L ++ K KL KL QE+ +++N
Sbjct: 1025 KAKTKL--EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMEN-------- 1074
Query: 635 IEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQ---NR 691
D +Q ++E + E LIS++ ++++ L+ + K + + G + +R
Sbjct: 1075 --DKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132
Query: 692 GKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQ 751
K E Q LSRE E + + E A + ++ + +KL+ L+E + +
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV 1192
Query: 752 EKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLN 811
+ + + +L E+ L V +KLE+ K +LK + E I KA L
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKE---KSELKMETDDLSSNAEAISKAKGNL- 1248
Query: 812 RKWHDKGELLCH-LETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMD--DAFK 868
E +C LE QV E+K K E +++ + + LQ A E +D DA
Sbjct: 1249 -------EKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALV 1301
Query: 869 RQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMR--ELLEETCKNKKTMEAKIK 926
Q+ +A +I +L ++ ++ + N H ++ +LL E + ++ +A+++
Sbjct: 1302 SQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1361
Query: 927 Q-LAFALNEIQQ 937
+ L+ A +E+ Q
Sbjct: 1362 RALSKANSEVAQ 1373
Score = 89.0 bits (219), Expect = 2e-17
Identities = 147/673 (21%), Positives = 277/673 (41%), Gaps = 99/673 (14%)
Query: 353 KLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKL-- 410
+L + ID L + + E S + TD L +KG LE M L++++ +L
Sbjct: 1205 ELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKT 1264
Query: 411 ------------TVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQ--QQAAQIRLIQEV 456
T + + + + ++ + L + + ++ R K+ QQ +++ E
Sbjct: 1265 KEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEE 1324
Query: 457 ELKASAA--------DREIYLLRTSLHREREQAQQLHQLLALKEQE---HRKELETREFF 505
E KA A + LLR E+E +L + L+ E R + ET
Sbjct: 1325 ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ 1384
Query: 506 TDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFR-------------I 552
+ ++A K++A+ ++ E+ ++ K L + L+NE
Sbjct: 1385 RTEELEEA-KKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACA 1443
Query: 553 ALTVEARRFQDV----KDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKT 608
AL + R F V K +E EL S + ES SL +L + +
Sbjct: 1444 ALDKKQRNFDKVLSEWKQKYEETQAELEAS----------QKESRSLSTELFKVKNVYEE 1493
Query: 609 KLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISEL-AAKESLIF 667
L ++ L++E NLQ +I+ L I + ++ ++E +K + Q E+ AA E
Sbjct: 1494 SLDQLETLRRENK-NLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552
Query: 668 GLRTER-KVWGH--ELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESD--------S 716
L E K+ EL Q S + + + + +I+ L R + + +T +S +
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRN 1612
Query: 717 DALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVL 776
DALR+K K+ D E +L + E ++ + I K TQ LD+ +++
Sbjct: 1613 DALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNT-QGILKETQLHLDDALRGQEDLK 1671
Query: 777 EKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQ---VKEVKE 833
E+L R L+ +++ LE+ ++ ++ D E + L TQ + K+
Sbjct: 1672 EQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKK 1731
Query: 834 KFENKEKKLKAERDKSIELQKNAMEKLHS-------MDDAFKRQVD--AIVEAHQAEIAQ 884
K EN +L++E ++ I+ +NA EK M + K++ D A +E + + Q
Sbjct: 1732 KLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQ 1791
Query: 885 LANEKQKCIDSA--------NLKVHQIEKEMREL----------LEETCKNKKTMEAKIK 926
+ Q +D A ++ ++E +REL E K + E ++K
Sbjct: 1792 TVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVK 1851
Query: 927 QLAFALNEIQQDM 939
+L + E ++++
Sbjct: 1852 ELTYQTEEDRKNV 1864
Score = 72.8 bits (177), Expect = 1e-12
Identities = 121/534 (22%), Positives = 210/534 (39%), Gaps = 106/534 (19%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANE 367
+ES TE+ KV N Y+ ++QL+ R + +Q + L + I E K +E
Sbjct: 1475 KESRSLSTELFKVK------NVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHE 1528
Query: 368 KEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVEL---MKAKDQQEDH 424
E I ++ + S E + ++Q E+ ++ E+ + KD++ D
Sbjct: 1529 LEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQ 1588
Query: 425 LKH-----LRTLEKTLEKMERQKRQQQAAQIRL---IQEVELKASAADREIYLLRTSLHR 476
LK + T++ TL+ R + + ++ + E+E++ + A+R L SL
Sbjct: 1589 LKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANR---LAAESLRN 1645
Query: 477 ERE-----QAQQLHQLLALKEQEHRKE----LETREFFTDADFQD--ALAKEIAKEEKKH 525
R + QLH AL+ QE KE +E R A+ ++ A ++ + K
Sbjct: 1646 YRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIA 1705
Query: 526 EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWA 585
EQ + + E++ +L Q L N K EN ++L +I
Sbjct: 1706 EQELLDASERVQLLHTQNTSLIN---------------TKKKLENDVSQLQSEVEEVIQE 1750
Query: 586 QRK-ENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQ 644
R E ++ I D M +E K + Q+T+A+L+ LE ++D + + +
Sbjct: 1751 SRNAEEKAKKAITDAAMMAEELKKE--------QDTSAHLERMKKNLEQTVKDLQHRLDE 1802
Query: 645 IELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRE 704
E +LA +G + KLEA++ L E
Sbjct: 1803 AE--------------------------------QLALKGGK--KQIQKLEARVRELEGE 1828
Query: 705 NECLRKTNESDSDALRI---KCKIIDDQTETIRK-------LKDCLQEKDEHIKRLQEKI 754
E +K N LR + K + QTE RK L D LQ K + KR E+
Sbjct: 1829 VENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEE- 1887
Query: 755 TEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYS 808
+EQ + S+ ++ +LE ER + + Q+ V+ E+ S
Sbjct: 1888 ------AEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKIS 1935
Score = 41.6 bits (96), Expect = 0.004
Identities = 40/191 (20%), Positives = 80/191 (41%), Gaps = 4/191 (2%)
Query: 753 KITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGK---EVELEEIRKAYST 809
K E EK +E DE+ + + E +EK+ LK K +++++ + +
Sbjct: 844 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLAD 903
Query: 810 LNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKR 869
+ + LE ++KEV E+ E +E+ K +L+ E +DD
Sbjct: 904 AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELT 963
Query: 870 QVDAIVEAHQAE-IAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 928
E H E + E+ +D K+ + +K ++E ++T + + E K+ L
Sbjct: 964 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNIL 1023
Query: 929 AFALNEIQQDM 939
A +++Q +
Sbjct: 1024 TKAKTKLEQQV 1034
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 105 bits (261), Expect = 3e-22
Identities = 160/806 (19%), Positives = 334/806 (41%), Gaps = 144/806 (17%)
Query: 247 RKECNRKVPRRSKI---PYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLAN 303
R E + V RR I Y+ + +KH ++ K+KP LK +AN
Sbjct: 802 RVEYQKMVERRESIFCIQYNVRAFMNVKHW-----PWMKLYFKIKP-LLKSAETEKEMAN 855
Query: 304 CPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHK 363
M +E EK K E+ K + E + +V + ++ + + + + + L D + +
Sbjct: 856 --MKEEFEKTKEELAKTEAKRKE--LEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQ 911
Query: 364 HANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLT-----VELMKAK 418
K + + T+R ++ E +L KL++E +L +EL AK
Sbjct: 912 LIKTKIQLEAKIKEVTERAED----EEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 419 DQQEDHL---------KHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA------ 463
++E H + + L++T+ K+ ++K+ Q A + + +++ +
Sbjct: 968 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1027
Query: 464 ----DREIYLLRTSLHREREQAQQLHQLLA----------------------LKEQEHRK 497
++++ L SL +E++ L + L E+ +K
Sbjct: 1028 KIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK 1087
Query: 498 ELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDV-------LSQQYMDLENEF 550
E E + + + AL ++ K+ K+ + I+E +E+I+ +Q DL E
Sbjct: 1088 EFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147
Query: 551 RIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQK--- 607
E + G + E+ K + A R++ E ++L + T +K
Sbjct: 1148 E-----EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1202
Query: 608 --TKLAEVSKLKQETAANLQNQINTLEILIED--------DKQKS-------------IQ 644
+L E Q L+ + + +++ I+D K K +
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSE 1262
Query: 645 IELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQ-NRGK--LEAQIESL 701
I+ + E+ +LI++L A+ + L+TE + +L ++ + ++Q +RGK QIE L
Sbjct: 1263 IKTKEEEQQRLINDLTAQRAR---LQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEEL 1319
Query: 702 SRENECLRKTNESDSDAL---RIKCKIIDDQTETIRKLKDCLQ----EKDEHIKRLQEKI 754
R+ E K + + AL R C ++ +Q E ++ K LQ + + + + + K
Sbjct: 1320 KRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKY 1379
Query: 755 TEIEKCTQEQLDEKSSQLDEVLEKLERHNE-----------RKEKLKQQLKGKEVELEEI 803
E+L+E +L + L+ E H E K++L+ +++ +++E
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERT 1439
Query: 804 RKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSM 863
A + L++K + ++L + + +E + E +K+ ++ + ++ KNA E+
Sbjct: 1440 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKI-KNAYEESLDQ 1498
Query: 864 DDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEK----------EMRELLEE 913
+ KR+ + Q EI+ L + I ++H++EK E++ LEE
Sbjct: 1499 LETLKRENKNL----QQEISDLTEQ----IAEGGKRIHELEKIKKQVEQEKSELQAALEE 1550
Query: 914 TCKNKKTMEAKIKQLAFALNEIQQDM 939
+ + E KI ++ LN+++ ++
Sbjct: 1551 AEASLEHEEGKILRIQLELNQVKSEV 1576
Score = 94.7 bits (234), Expect = 3e-19
Identities = 148/675 (21%), Positives = 291/675 (43%), Gaps = 84/675 (12%)
Query: 333 LVEQLDQEREKRWRAEQAENKLMDYIDELHKH----ANEKEDIHSLALLTTDRLKEIIFR 388
L EQ+D + + + E+ ++++ ID+L + + K ++ + D+L EI +
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTK 1266
Query: 389 ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQ--QQ 446
E Q I LT + + + + ++ + L + + ++ R K+ QQ
Sbjct: 1267 EEEQ-----------QRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315
Query: 447 AAQIRLIQEVELKASAA--------DREIYLLRTSLHREREQAQQLHQLLALKEQE---H 495
+++ E E+KA +A + LLR E+E +L + ++ E
Sbjct: 1316 IEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQW 1375
Query: 496 RKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFR---- 551
R + ET + ++A K++A+ + E+ ++ K L + L+NE
Sbjct: 1376 RTKYETDAIQRTEELEEA-KKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMI 1434
Query: 552 -IALTVEARRFQDVKD-GFENVATEL---AKSKHALIWAQRKENESSSLIKDLTCMVKEQ 606
+ T A D K F+ + E + HA + A +KE S SL +L +
Sbjct: 1435 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE--SRSLSTELFKIKNAY 1492
Query: 607 KTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISEL-AAKESL 665
+ L ++ LK+E NLQ +I+ L I + ++ ++E +K + Q SEL AA E
Sbjct: 1493 EESLDQLETLKRENK-NLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEA 1551
Query: 666 IFGLRTER-KVWGH--ELAQQGSSLAQNRGKLEAQIESLSREN----ECLRKTNESD--- 715
L E K+ EL Q S + + + + +I+ + R + E ++ T +++
Sbjct: 1552 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRS 1611
Query: 716 -SDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDE 774
+DA+R+K K+ D E +L + E ++ + I K TQ LD+ ++
Sbjct: 1612 RNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNT-QAILKDTQLHLDDALRSQED 1670
Query: 775 VLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQ---VKEV 831
+ E+L R L+ +++ LE+ ++ ++ D E + L TQ +
Sbjct: 1671 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1730
Query: 832 KEKFENKEKKLKAERDKSIELQKNAMEKLHS-------MDDAFKRQVD--AIVEAHQAEI 882
K+K E +++ E + I+ +NA EK M + K++ D A +E + +
Sbjct: 1731 KKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790
Query: 883 AQLANEKQKCIDSA--------NLKVHQIEKEMRELLEET-CKNKKTMEA---------K 924
Q + Q +D A ++ ++E +REL E + K+ +EA K
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERK 1850
Query: 925 IKQLAFALNEIQQDM 939
+K+L + E ++++
Sbjct: 1851 VKELTYQTEEDRKNI 1865
Score = 68.2 bits (165), Expect = 3e-11
Identities = 135/643 (20%), Positives = 266/643 (41%), Gaps = 118/643 (18%)
Query: 296 YVSSSLANCPMLQESEKPKTEIIKVDQSHSE---------DNTYQSL---VEQLDQEREK 343
Y + ++ L+E++K + ++ + H E + T Q L VE L + E+
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 344 RWRAEQAENKLMDYIDELHKHANEK-EDIHSLALLTTDRLKEI---IFRERNSKGQLEVM 399
A A +K D++ +K E+ H+ + + + +F+ +N+ +
Sbjct: 1439 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQ 1498
Query: 400 VHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELK 459
+ L+ E K L E+ +Q + K + LEK +++E++K + QAA ++E E
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAA----LEEAE-- 1552
Query: 460 ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIA 519
AS E +LR L +L +K + RK E E EI
Sbjct: 1553 ASLEHEEGKILRIQL-----------ELNQVKSEVDRKIAEKDE-------------EID 1588
Query: 520 KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK 579
+ ++ H ++++ Q +D + D A+ ++ + D+ + + +L +
Sbjct: 1589 QMKRNHIRIVESMQSTLDAEIRSRND-------AIRLKKKMEGDLNE----MEIQLNHAN 1637
Query: 580 HALIWAQRKENESSSLIKDLTCMVKE---QKTKLAEVSKLKQETAANLQNQINTLEILIE 636
A R + +++KD + + + L E + + A LQ +I L +E
Sbjct: 1638 RMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLE 1697
Query: 637 --DDKQKSIQIELL-KHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGK 693
+ +K + ELL E+VQL L Q +SL + K
Sbjct: 1698 QTERSRKIAEQELLDASERVQL------------------------LHTQNTSLINTKKK 1733
Query: 694 LEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEK 753
LE I + E E + + + + + K I D +LK Q+ H++R+++
Sbjct: 1734 LETDISQIQGEMEDIIQEARNAEEKAK---KAITDAAMMAEELKK-EQDTSAHLERMKKN 1789
Query: 754 ITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRK 813
+ + K Q +LDE + QL L+ ++ ++ E ++L+G EVE E+ R + +
Sbjct: 1790 LEQTVKDLQHRLDE-AEQL--ALKGGKKQIQKLEARVRELEG-EVESEQKRNVEAVKGLR 1845
Query: 814 WHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDA 873
H E +VKE+ + E K + + LQ + ++KL + ++KRQ +
Sbjct: 1846 KH---------ERKVKELTYQTEEDRKNI-------LRLQ-DLVDKLQAKVKSYKRQAEE 1888
Query: 874 IVEAHQAEIAQL------ANEKQKCIDSANLKVHQIEKEMREL 910
E +++ E ++ D A +V+++ + RE+
Sbjct: 1889 AEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 103 bits (258), Expect = 6e-22
Identities = 143/688 (20%), Positives = 286/688 (41%), Gaps = 94/688 (13%)
Query: 315 TEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSL 374
T++ + Q ++ + E+L + REK+ AE ++ +L + ++
Sbjct: 832 TKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQA 891
Query: 375 ALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHL----RT 430
+E+ R K +LE + H L+ + +++E+ +HL +
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARV-----------EEEEERCQHLQAEKKK 940
Query: 431 LEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLAL 490
+++ ++++E Q ++++A+ Q+++L+ + ++ L E EQ Q L
Sbjct: 941 MQQNIQELEEQLEEEESAR----QKLQLEKVTTEAKLKKL------EEEQIILEDQNCKL 990
Query: 491 KEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKI-------------- 536
+++ E EF T+ ++ +K +AK + KHE MI + +E++
Sbjct: 991 AKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTR 1050
Query: 537 -------DVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKE 589
LS Q +L+ + A++ ++++ V E A+ AL + E
Sbjct: 1051 RKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELE 1110
Query: 590 NESSSLIKDLTC------MVKEQKTKLAE--------------VSKLKQETAANLQNQIN 629
++ S L +DL ++QK L E + +QE + + ++N
Sbjct: 1111 SQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVN 1170
Query: 630 TLEILIEDD-KQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLA 688
L+ +E++ K QI+ ++ + Q + ELA + +T+R E A+Q +L
Sbjct: 1171 ILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE-----QTKRVKANLEKAKQ--TLE 1223
Query: 689 QNRGKLEAQIESLSR---ENECLRKTNESDSDALRIKCKIIDD-QTETIRKLKDCLQEKD 744
RG+L +++ L + ++E RK E+ L++K + +TE K+ E D
Sbjct: 1224 NERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELD 1283
Query: 745 EHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIR 804
L + ++ K T++ SQL + E L+ N +K L +LK E E R
Sbjct: 1284 NVTGLLSQSDSKSSKLTKD-FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR 1342
Query: 805 KAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKN--------- 855
+ H+ + + L QV ++K+K E+ L+ + +LQK+
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 856 ----AMEKLHSMDDAFKRQVDAIVE--AHQAEIAQLANEKQKCIDSANLKVHQIEKEMRE 909
A +KL ++++D ++ HQ + A +KQK D + I + E
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 910 LLEETCKNKKTMEAKIKQLAFALNEIQQ 937
+ + E K LA AL E +
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAME 1490
Score = 102 bits (253), Expect = 2e-21
Identities = 174/839 (20%), Positives = 356/839 (42%), Gaps = 142/839 (16%)
Query: 201 EIKLQKLDDQILQLLNETSN---SIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 257
E KL+KL+++ Q++ E N + + L +D + T++T E + K + +
Sbjct: 970 EAKLKKLEEE--QIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE--KSKSLAKLKNKH 1025
Query: 258 SKIPYDAKTIQTIKHHNKNYNSFVSCNRKMK------PPYLKELYVSSSLANCPMLQESE 311
+ D + + ++ K RK++ + EL + + ++ E
Sbjct: 1026 EAMITDLE--ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 312 KPKTEIIKVDQSHSEDNT-----------YQSLVEQLDQEREKRWRAEQAENKLMDYIDE 360
+ + + +V++ ++ N L E L+ ER R +AE+ + D +E
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKR---DLGEE 1140
Query: 361 LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHK--LQNEIKKLTVELMKAK 418
L E ED L +T +E+ SK + EV + K L+ E K ++
Sbjct: 1141 LEALKTELED----TLDSTAAQQEL-----RSKREQEVNILKKTLEEEAKTHEAQI---- 1187
Query: 419 DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRT----SL 474
QE KH + +E+ E++E+ KR + + + Q +E + E+ +L S
Sbjct: 1188 --QEMRQKHSQAVEELAEQLEQTKRVKANLE-KAKQTLENERGELANEVKVLLQGKGDSE 1244
Query: 475 HREREQAQQLHQLLALKEQEHRKELETREFFTDADFQ-DALAKEIAKEEKKHEQMIKEYQ 533
H+ ++ QL +L + R E + T + D + +++ + K ++ K++
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 534 EKIDVL--SQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKH------ALIWA 585
L +Q+ + EN +++L+ + ++ +D K+ F E ++KH A + A
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 586 Q----RKENESS------------SLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQIN 629
Q +K+ E S L KDL + + + K+A KL ++T LQ +++
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKL-EKTKTRLQQELD 1423
Query: 630 TLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQ 689
L + ++ +Q + +E +K + +L A+E I E + A++ + A
Sbjct: 1424 DLLVDLDHQRQSACNLE----KKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKAL 1479
Query: 690 NRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKR 749
+ + + E E L K ++ + L + + K K L+++ E +K
Sbjct: 1480 SLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKT 1539
Query: 750 LQEKITEIEKCTQE-------QLDEKSSQLDEVLE-KLERHNERKEKLKQQLKGKEVELE 801
E++ + + T++ L +Q + L+ + E+ E+K++L +Q++ E ELE
Sbjct: 1540 QLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE 1599
Query: 802 EIRKAYS---------------------TLNRKWHDKGELLCHLETQVK----------- 829
+ RK S + N+ + + L L+ Q+K
Sbjct: 1600 DERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRA 1659
Query: 830 ---EVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQ-- 884
E+ + + EKKLK+ + I+LQ E+L + + A KRQ + EIA
Sbjct: 1660 SREEILAQAKENEKKLKSMEAEMIQLQ----EELAAAERA-KRQAQQERDELADEIANSS 1714
Query: 885 ----LANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 939
LA E+++ +++ ++ Q+E+E LEE N + + ++K+ +++I D+
Sbjct: 1715 GKGALALEEKRRLEA---RIAQLEEE----LEEEQGNTELINDRLKKANLQIDQINTDL 1766
Score = 99.0 bits (245), Expect = 2e-20
Identities = 120/563 (21%), Positives = 249/563 (44%), Gaps = 48/563 (8%)
Query: 398 VMVHKLQNEIKKLTVELMKAKDQQ---EDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQ 454
+ V + + E+ EL+K +++Q E+ L + TL+ L + Q ++Q A+ L
Sbjct: 838 LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897
Query: 455 EVE---LKASAADREI----YLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTD 507
E E + +A +E+ + L + E E+ Q L Q K Q++ +ELE +
Sbjct: 898 EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL-QAEKKKMQQNIQELEEQ----- 951
Query: 508 ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG 567
+ +++ +++ E+ E +K+ +E+ +L Q L E ++ ++D
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL-----------LEDR 1000
Query: 568 FENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AANL 624
T L + + + +N+ ++I DL ++ ++ + E+ K +++ + +L
Sbjct: 1001 IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060
Query: 625 QNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQG 684
+QI L+ I + K + + E + + E AA++++ E + EL +
Sbjct: 1061 SDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120
Query: 685 SSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKD 744
S +R K E Q L E E L+ E D+ + ++ + + + LK
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK------- 1173
Query: 745 EHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIR 804
K L+E+ E QE + S ++E+ E+LE+ K L++ + E E E+
Sbjct: 1174 ---KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA 1230
Query: 805 KAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDK--SIELQKNAMEKLHS 862
L + D +E Q++E++ KF E+ DK ++++ + + L S
Sbjct: 1231 NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290
Query: 863 MDDAFKRQVD---AIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKE---MRELLEETCK 916
D+ ++ + +E+ + +L E+ + S + K+ Q+E E RE LEE +
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE 1350
Query: 917 NKKTMEAKIKQLAFALNEIQQDM 939
K +E +I L + ++++ M
Sbjct: 1351 AKHNLEKQIATLHAQVADMKKKM 1373
Score = 99.0 bits (245), Expect = 2e-20
Identities = 154/706 (21%), Positives = 302/706 (42%), Gaps = 105/706 (14%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQER----EKRWRAEQAENKLMDYIDELHK 363
+ES + K ++ KV T ++ +++L++E+ ++ + + + L D I E
Sbjct: 955 EESARQKLQLEKV--------TTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTT 1006
Query: 364 HANEKED-IHSLALLTTDR------LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMK 416
+ E+E+ SLA L L+E + RE + +LE KL+ + L+ ++ +
Sbjct: 1007 NLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE 1066
Query: 417 AKDQQEDHLKHLRTLEKTLE----KMERQKRQQQAAQIRLIQEVELKASAADREIYLLRT 472
+ Q + L E+ L+ ++E + Q+ A ++ I+E+E + S ++ R
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA-LKKIRELESQISELQEDLESERA 1125
Query: 473 SLHREREQAQQLHQLLALKEQEHRKELET----REFFTDADFQ-DALAKEIAKEEKKHEQ 527
S ++ +Q + L + L + E L++ +E + + + + L K + +E K HE
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185
Query: 528 MIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWA-- 585
I+E ++K SQ +L + V+A + K EN ELA L+
Sbjct: 1186 QIQEMRQKH---SQAVEELAEQLEQTKRVKAN-LEKAKQTLENERGELANEVKVLLQGKG 1241
Query: 586 ----------------QRKENESSSLIKDLTCMVKEQKTKLAEV-----------SKLKQ 618
Q K NE + +L V + + +L V SKL +
Sbjct: 1242 DSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTK 1301
Query: 619 ETAANLQNQI-NTLEILIEDDKQK---SIQIELLKHEKVQLISELAAKESLIFGLRTERK 674
+ +A L++Q+ +T E+L E+++QK S +++ ++ EK +L +E L +
Sbjct: 1302 DFSA-LESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIA 1360
Query: 675 VWGHELAQQGSSLAQNRG----------KLEAQIESLSRENE-------CLRKTNESDSD 717
++A + + G KL+ +E LS+ +E L KT
Sbjct: 1361 TLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420
Query: 718 ALRIKCKIIDDQTETIRKLKDCLQEKDEHI---KRLQEKITEIEKCTQEQLDEKSSQLDE 774
L +D Q ++ L+ ++ D+ + K + K E + + EK ++
Sbjct: 1421 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480
Query: 775 VLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEK 834
+ LE E+K +L++ K E+E++ + + + H+ + LE QV+E+K +
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540
Query: 835 FENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANE------ 888
E E +L+A D + L+ N L +M F+R + E + + QL +
Sbjct: 1541 LEELEDELQATEDAKLRLEVN----LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEA 1596
Query: 889 ------KQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 928
KQ+ + A K ++E ++++L K + IKQL
Sbjct: 1597 ELEDERKQRSMAVAARK--KLEMDLKDLEAHIDSANKNRDEAIKQL 1640
Score = 85.5 bits (210), Expect = 2e-16
Identities = 132/618 (21%), Positives = 248/618 (40%), Gaps = 102/618 (16%)
Query: 306 MLQESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKH 364
+LQE + K + K+ Q E N+++ EQL++E E + E+ L + ++ K
Sbjct: 1316 LLQEENRQKLSLSTKLKQVEDEKNSFR---EQLEEEEEAKHNLEKQIATLHAQVADMKKK 1372
Query: 365 ANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDH 424
+ L T + +K + ++ Q ++++K L + D
Sbjct: 1373 MEDSVG----CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVD 1428
Query: 425 LKHLR----TLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQ 480
L H R LEK +K ++ +++ + +E + +A A RE SL R E+
Sbjct: 1429 LDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD-RAEAEAREKETKALSLARALEE 1487
Query: 481 AQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLS 540
A + L ++ R E+E + + D E+ K ++ EQ ++E + +++ L
Sbjct: 1488 AMEQKAELERLNKQFRTEME--DLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELE 1545
Query: 541 QQYMDLEN-EFRIALTVEARRFQDVKD--GFENVATELAKS-----------------KH 580
+ E+ + R+ + ++A + Q +D G + + E K +
Sbjct: 1546 DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605
Query: 581 ALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTL-------EI 633
++ A RK+ E +KDL + E K ++ A +++ + L E
Sbjct: 1606 SMAVAARKKLEMD--LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE 1663
Query: 634 LIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQ---QGSSLAQN 690
++ K+ +++ ++ E +QL ELAA E + ER E+A +G+ +
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
Query: 691 RGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI--- 747
+ +LEA+I L E E + E +D L+ K + DQ T L+ +K+E+
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELINDRLK-KANLQIDQINTDLNLERSHAQKNENARQQ 1782
Query: 748 -----KRLQEKITEIE-------KCTQEQLDEKSSQLDEVLE----------KLERHNER 785
K L+ K+ E+E K + L+ K +QL+E L+ K R E+
Sbjct: 1783 LERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK 1842
Query: 786 KEK-----------------------------LKQQLKGKEVELEEIRKAYSTLNRKWHD 816
K K LK+QL+ E E + + L R+ D
Sbjct: 1843 KLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED 1902
Query: 817 KGELLCHLETQVKEVKEK 834
E + +V +K K
Sbjct: 1903 ATETADAMNREVSSLKNK 1920
Score = 50.1 bits (118), Expect = 1e-05
Identities = 69/355 (19%), Positives = 147/355 (41%), Gaps = 35/355 (9%)
Query: 198 LQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRR 257
L+ E+ LQ + Q + L + ++ R R+ + E + RK+ + V R
Sbjct: 1556 LRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDE---RKQRSMAVAAR 1612
Query: 258 SKIPYDAKTIQT-IKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPM-LQESEKPKT 315
K+ D K ++ I NKN + + RK++ + + +C L ++ +
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ----------AQMKDCMRELDDTRASRE 1662
Query: 316 EIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLA 375
EI+ Q+ + +S+ ++ Q +E+ AE+A+ + DEL +LA
Sbjct: 1663 EILA--QAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720
Query: 376 LLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTL 435
L RL+ I + + + + + +KK +++ + H + E
Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780
Query: 436 EKMERQKRQQQAAQIRLIQEVE------LKAS--AADREIYLLRTSLHREREQAQQLHQL 487
+++ERQ ++ + +QE+E KAS A + +I L L E ++ Q
Sbjct: 1781 QQLERQNKELKVK----LQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQ----- 1831
Query: 488 LALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQ 542
A +Q R E + ++ D + A++ + K +K+ + +++ ++
Sbjct: 1832 -AACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEE 1885
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 103 bits (257), Expect = 8e-22
Identities = 135/684 (19%), Positives = 284/684 (41%), Gaps = 95/684 (13%)
Query: 307 LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHAN 366
LQ+ + + ++ ++ Q S T + V +L +E +R AE H
Sbjct: 232 LQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE---------------HER 276
Query: 367 EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 426
+ +++ L L+E+ R K L ++ ++ L + + AK +EDH +
Sbjct: 277 QAKEL----FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
Query: 427 ---------HLRTLEKTLEKMERQ---------KRQQQAAQIRLIQEVELKASAADREIY 468
H+ LE LE+ E++ +R + A + ++ D +I
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 469 LLRTSLHREREQAQQLHQLLALKEQEHRKELETREFF-TDADFQDALAKEIAKEEKKHEQ 527
+ L E+ Q L AL +E +E++ E + + + F ++ +E + +
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDT 452
Query: 528 MIKEYQEKIDVLSQQYMDLENEFRI---ALTVEARRFQDVKDGFENVATELAKSKHALIW 584
+ Q K++ L+ Q+ D + + +LT + +R ++ + + L
Sbjct: 453 ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRL--------- 503
Query: 585 AQRKENESSSLIKDLTCMVKEQKTKLAEVSKLK-------------QETAANLQNQINTL 631
+ KE + K + M +E+ T+ E+ LK Q+ NLQ Q+
Sbjct: 504 -EEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK 562
Query: 632 EILIEDDKQ--KSIQIELLKHEKVQLISE--LAAKESLIFGLRTERKVWGHELAQQGSSL 687
E + K+ KS+Q + + E LA KE I L+ +R E ++ +
Sbjct: 563 EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNY 622
Query: 688 AQNRGKLEAQIE----SLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEK 743
++ L+ ++ LS + L E S K + ++ L+ L++K
Sbjct: 623 KKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK----KDSRLKTLEIALEQK 678
Query: 744 DEHIKRLQEKITEIEKCTQEQLDEKSS-QLDEVLEKLERHNERKEKLKQQLKGKEVELEE 802
E +++ ++++K + L+ ++S ++ + ++ LER R K + + E++
Sbjct: 679 KEECLKME---SQLKKAHEAALEARASPEMSDRIQHLEREITR---YKDESSKAQAEVDR 732
Query: 803 IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIEL-------QKN 855
+ + + + +DK + + LE QVK+ +K N + K + E+ KS ++ + N
Sbjct: 733 LLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN 792
Query: 856 AMEKLHSMDDAFKRQVDAIVEAHQA--EIAQLANEKQKCIDSANLKVHQIEKEMRELL-- 911
+ + D+ +++ D I E +A E Q+ E++ + EK++ ELL
Sbjct: 793 LNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMA 852
Query: 912 -EETCKNKKTMEAKIKQLAFALNE 934
E+ + ++M+AK+ +L E
Sbjct: 853 MEKVKQELESMKAKLSSTQQSLAE 876
Score = 70.1 bits (170), Expect = 9e-12
Identities = 115/571 (20%), Positives = 238/571 (41%), Gaps = 68/571 (11%)
Query: 335 EQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKG 394
E++ Q R ++ +NK+ EL ++D LAL T +L+ + + +SK
Sbjct: 421 EEMKQMEVYRSHSKFMKNKIGQVKQEL-----SRKDTELLALQT--KLETLTNQFSDSKQ 473
Query: 395 QLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQ 454
+EV+ L + ++ + L D L+ T+ K + +++ Q I
Sbjct: 474 HIEVLKESLTAKEQRAAI-LQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 532
Query: 455 EVELKASAADREIYLLRTSLHREREQAQQLH-QLLALKEQEHRKELETREFFTD-ADFQD 512
+++ +R++ +L+ + +EQ + Q+ +LKE+ + +T T ++
Sbjct: 533 DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 592
Query: 513 ALAKEIAKEEKKHEQMIK---EYQEKIDVLSQQYMDLENEFRIA---LTVEARRFQDVKD 566
ALA++ E+ EQ + E QE+ID + DL+ + + L+ + D+K+
Sbjct: 593 ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 652
Query: 567 GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQN 626
++A+ K L K E + K C+ E + K A + L+ + + +
Sbjct: 653 HASSLASSGLKKDSRL-----KTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSD 707
Query: 627 QINTLEILIEDDKQKSIQIELLKHEKVQLISELAA----KESLIFGLRTERKVWGHELAQ 682
+I LE I K +S + + ++++ E+ K+ I L + K ++A
Sbjct: 708 RIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVAN 767
Query: 683 QGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQE 742
+ K +E R + L +++ D+LR K I++ E +R+ E
Sbjct: 768 LKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE 827
Query: 743 KDEHI-----------KRLQEKITEIEKC-------------TQEQLDEKSSQLDEVLEK 778
++ + K+++E + +EK TQ+ L EK + L + +
Sbjct: 828 REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 887
Query: 779 LERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENK 838
+H E ++KQ E + A S +K + LE + K+K + +
Sbjct: 888 RRKHLEEVLEMKQ---------EALLAAIS-------EKDANIALLE--LSSSKKKTQEE 929
Query: 839 EKKLKAERDKSI-ELQKNAMEKLHSMDDAFK 868
LK E+D+ + +L++ ++ M D ++
Sbjct: 930 VAALKREKDRLVQQLKQQTQNRMKLMADNYE 960
Score = 43.9 bits (102), Expect = 7e-04
Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 44/304 (14%)
Query: 201 EIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKR-------DTDITSESDYGNRKECNRK 253
EI L++ ++ L++ ++ + + LE P+ + +IT D ++ + +
Sbjct: 672 EIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQA--E 729
Query: 254 VPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKP 313
V R +I K ++ K N R++K K +AN ++ EK
Sbjct: 730 VDRLLEI---LKEVENEK--NDKDKKIAELERQVKDQNKK-------VANLKHKEQVEKK 777
Query: 314 KTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHS 373
K+ + + EDN S + D R+K R E+ E L + +
Sbjct: 778 KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ-------------- 823
Query: 374 LALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEK 433
+T +R + ++ +E +++ E V +L ++K+ EL K + + L E
Sbjct: 824 ---ITAER-EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET 879
Query: 434 TLEKMERQKRQQQAAQIRLIQEVELKA-SAADREIYLLRTSLHREREQAQQLHQLLALKE 492
L + ++R+ + + QE L A S D I LL S +++ Q ++ ALK
Sbjct: 880 HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQ----EEVAALKR 935
Query: 493 QEHR 496
++ R
Sbjct: 936 EKDR 939
Score = 39.3 bits (90), Expect = 0.017
Identities = 63/295 (21%), Positives = 116/295 (39%), Gaps = 65/295 (22%)
Query: 694 LEAQIESLSRENECLRKTNESD---------------SDALRIKCKIIDDQTETIRKLKD 738
L+ Q++ + REN+ LRK E S L+ + + D+ I K+
Sbjct: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213
Query: 739 ---CLQEKDEHIK----------RLQEKITEI----------EKCTQEQLDEKSSQLDEV 775
+QE+++H++ R+Q + ++ E C E +E +L
Sbjct: 214 QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273
Query: 776 LEK-----------LERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKW---------H 815
E+ LE R E KQ L ++ E I+K L K H
Sbjct: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARD---ESIKKLLEMLQSKGLSAKATEEDH 330
Query: 816 DKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAME--KLHSMDDAFKRQVDA 873
++ L E V ++ E KEK+ R++ +NA + K ++ + + D+
Sbjct: 331 ERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK-DS 389
Query: 874 IVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 928
+ + + + L E Q + L + E+EM++ +E + K M+ KI Q+
Sbjct: 390 KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ-MEVYRSHSKFMKNKIGQV 443
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 103 bits (257), Expect = 8e-22
Identities = 140/660 (21%), Positives = 285/660 (43%), Gaps = 93/660 (14%)
Query: 311 EKPKTEIIKVDQSHSEDNTYQSLVEQLD-QEREKRWRAEQAENKLMDYIDELHKHA---N 366
EKP +E+ ++++ E TY+ ++EQL E+ R + EN E HKH N
Sbjct: 145 EKPISELDRLEEKQKE--TYRRMLEQLLLAEKCHRRTVYELEN-------EKHKHTDYMN 195
Query: 367 EKEDIHSLALLTTDRLKEIIFRERNSKGQLEV----MVHKLQNEIKKLTVELMKAKDQQE 422
+ +D +L +RLK+++ +E+ + + E ++KL++E+ KL + D+++
Sbjct: 196 KSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQ 255
Query: 423 DHLKHL--------------RTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIY 468
H++ L R E+ L+ + + ++ + ++L + E KAS +E
Sbjct: 256 MHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHE 315
Query: 469 LLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQ-DALAKEIAKEEKKHEQ 527
+ L + +QL L Q + ET + A+ + L +IAK E +
Sbjct: 316 EMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSS 375
Query: 528 MIKEYQ-------------EKIDVLSQQYMDL------ENEFRIALTVEARRFQDVKDGF 568
++ E + E+I Q +L E L +E + Q
Sbjct: 376 LMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSEL 435
Query: 569 ENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQI 628
E + +KSK + +L KDL ++ K+++ E+ ++++
Sbjct: 436 EKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECS--------ESRL 487
Query: 629 NTLEILIEDD--KQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWG-------HE 679
E+ ++DD K KS + +L E+ ++ ++ +E + GL KV +
Sbjct: 488 EKAELSLKDDLTKLKSFTV-MLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEK 546
Query: 680 LAQQGSSLAQNRGKLEAQIESLSRE-NECLRKTNESDSDALRIKCKIIDDQTETIRKLKD 738
L ++ L + + ++E ++ +L+RE +E + K + + + C + + ++K D
Sbjct: 547 LIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSV-----DLLKKRLD 601
Query: 739 CLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEV 798
++E + I R + + C + D +++L ER +K QQL+ E
Sbjct: 602 GIEEVEREITRGRSRKGSELTCPE----------DNKIKELTLEIERLKKRLQQLEVVEG 651
Query: 799 ELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAME 858
+L + Y L +K+ + + L Q++E+K + K KA + Q+ +
Sbjct: 652 DLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQI----AKNKAIEKGEVVSQEAELR 707
Query: 859 KLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNK 918
+++A R + A V+A + +I +L N++ + + L+V + R +EE KNK
Sbjct: 708 HRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQL---SQLQVDYSVLQQR-FMEEENKNK 763
Score = 45.4 bits (106), Expect = 2e-04
Identities = 79/349 (22%), Positives = 146/349 (41%), Gaps = 75/349 (21%)
Query: 306 MLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHA 365
+++ES+K ++K+ +S E+ Y +L + D+ K E+ ++L +D L K
Sbjct: 547 LIEESKK----LLKL-KSEMEEKVY-NLTRERDELIGKLKSEEEKSSELSCSVDLLKKRL 600
Query: 366 NEKEDIHSLALLTTDRL-KEIIFRERNSKGQLEVMVHKLQNEIKKLTV---ELMKAKDQQ 421
+ E++ R E+ E N +L + + +L+ +++L V +LMK +D+
Sbjct: 601 DGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEY 660
Query: 422 EDHLKHLRT-------LEKTLEKMERQKRQQQAAQIRLI--QEVELK-------ASAAD- 464
+ + RT L + LE+++ Q + +A + + QE EL+ A + D
Sbjct: 661 DQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDL 720
Query: 465 -REIYLLRTSLHREREQAQQLHQLLA--------LKEQEHR------------KELETRE 503
E+ L+ +H + QL QL E+E++ KELE +
Sbjct: 721 KAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSK 780
Query: 504 FF------------------TDADFQ-DALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYM 544
+ T Q DA++ E A+EE + K +QE+ ++S
Sbjct: 781 RYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMS---- 836
Query: 545 DLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESS 593
N ++ L R V D + A EL K + W +++EN S
Sbjct: 837 ---NLRQVGLKKPVER-SSVLDRYPPAANELTMRKSWIPWMRKRENGPS 881
Score = 43.9 bits (102), Expect = 7e-04
Identities = 72/363 (19%), Positives = 158/363 (43%), Gaps = 42/363 (11%)
Query: 597 KDLTCMVKEQKTKL----AEVSKLKQETAANL--QNQINTLEILIEDDKQKSIQIELLKH 650
+D+ M+K +KTK A + E + ++ I E I +D + EL +
Sbjct: 95 EDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRL 154
Query: 651 EKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRK 710
E+ Q + E L+ + R+ +EL + K + L +E E L+K
Sbjct: 155 EEKQKETYRRMLEQLLLAEKCHRRTV-YELENEKHKHTDYMNKSDDFTNLLEQERERLKK 213
Query: 711 TNESDSDALRIKCKIIDDQTETIRKLKDCL-----------QEKDEHIKRLQEKITEIEK 759
E + K K + + + KL+D L E+ HI++L + +++
Sbjct: 214 LLEQEKAYQARKEK---ENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQD 270
Query: 760 CTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGE 819
TQ+ +E+ EKL+ + ++ +Q+L EV+ E +S + + + K
Sbjct: 271 LTQKLREEE--------EKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAK-- 320
Query: 820 LLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQ 879
L + E+ ++++ K ++++ + + LQK A E+L + D + +
Sbjct: 321 -LANQESHNRQLRLKLVGLTQRIEELEETNKNLQK-AEEELQELRDKIAKGECG----NS 374
Query: 880 AEIAQLANEKQKCI-----DSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNE 934
+ +A++ N +++ + D K +E+R+ L+E + K + ++++L ++E
Sbjct: 375 SLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSE 434
Query: 935 IQQ 937
+++
Sbjct: 435 LEK 437
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 102 bits (255), Expect = 1e-21
Identities = 130/680 (19%), Positives = 299/680 (43%), Gaps = 50/680 (7%)
Query: 184 CQSSEPEK---NNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITS 240
C S E EK + H+ L+ EI+ Q D +++L ++ L R +
Sbjct: 66 CHSPEDEKKASHQHQEALRREIEAQ---DHTIRILTCQKTELETALYYSQDAARKFE--- 119
Query: 241 ESDYGNRKECNRKVPRRSKIPYDA-KTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSS 299
+ + G K+ ++ + + + + +K + ++ K + ELY +
Sbjct: 120 DGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIEELTKERDALSLELY-RN 178
Query: 300 SLANCPMLQESEKPKTEII-KVDQSHSEDNTYQSLVEQLDQEREK-RWRAEQAENKLMDY 357
++ N +E +K E+ K+ + SE + Q V++L ++ E+ ++ Q + +
Sbjct: 179 TITN----EELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ- 233
Query: 358 IDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKA 417
+E+ + E + +++ R R +G++ K++ + K+L E K
Sbjct: 234 -EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLR-EQEKE 291
Query: 418 KDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRE 477
+QE L+ + L + E+M+ Q+ + + ++ +E E K + ++ + RE
Sbjct: 292 LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKM-REQEEKMWRQEERLWEQEKQM-RE 349
Query: 478 REQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKID 537
+EQ + + ++ E +E E R + ++ +E +EE++ + K+ +E+ +
Sbjct: 350 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ---EEKMQEEERIREREKKMREEEE 406
Query: 538 VLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIK 597
+ +Q ++ + E + +Q + L + K L W Q K E I
Sbjct: 407 TMREQEEKMQKQEENMWEQEEKEWQQQR---------LPEQKEKL-WEQEKMQEQEEKIW 456
Query: 598 DLTCMVKEQKTKLAEVSKL-KQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLI 656
+ +++Q+ + K+ +QE ++Q+ E + D +QK E E+ + +
Sbjct: 457 EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERL 516
Query: 657 SELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLR---KTNE 713
E + +R ++K+W E + Q + K E RE E +R K
Sbjct: 517 REKEER------MREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570
Query: 714 SDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLD 773
+ + +R + + + +Q E +R+ ++ + E++E ++ +EK+ E E+ EQ +E Q
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ 630
Query: 774 EVL-----EKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQV 828
E + EK++ E+ + +++++ +E ++ E + K ++ E + E ++
Sbjct: 631 EEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKM 690
Query: 829 KEVKEKFENKEKKLKAERDK 848
+E +EK +E+K+ + +K
Sbjct: 691 REQEEKMRGQEEKMWGQEEK 710
Score = 85.1 bits (209), Expect = 3e-16
Identities = 114/588 (19%), Positives = 260/588 (44%), Gaps = 66/588 (11%)
Query: 357 YIDELHKHANEKEDIHSLAL----LTTDRLK-------EIIFRERNSKGQLEVMVHKLQN 405
YI+EL K + D SL L +T + LK E + + K ++++ V +L+
Sbjct: 160 YIEELTK----ERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKR 215
Query: 406 EIK--KLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA 463
+++ K + ++ QE+ + L + +K+ +Q+ + + RL +E E K
Sbjct: 216 KLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERL-REQEGKMREQ 274
Query: 464 DREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEK 523
+ + +R R REQ ++L + +E+E R++ + RE + Q+ K +EEK
Sbjct: 275 EEK---MRRQEKRLREQEKELRE----QEKELREQKKLRE--QEEQMQEQEEKMWEQEEK 325
Query: 524 KHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALI 583
EQ K ++++ + Q+ E E ++ E QD + + E + +
Sbjct: 326 MREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK----EERMREQEKM 381
Query: 584 WAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSI 643
W Q ++ + I++ ++E++ + E + Q+ N+ Q ++K
Sbjct: 382 WEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ-----------EEKEW 430
Query: 644 QIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSR 703
Q + L +K +L + +E E K+W E K+ Q E +
Sbjct: 431 QQQRLPEQKEKLWEQEKMQEQ-------EEKIWEQE------------EKIRDQEEMWGQ 471
Query: 704 ENECLRKTN-ESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQ 762
E + R+ D + + + + DQ + + ++ + E+DE ++ +E++ E +K Q
Sbjct: 472 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQ 531
Query: 763 EQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLC 822
++ + + + EK E K + +++++ +E ++ E + K ++ E +
Sbjct: 532 QEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMR 591
Query: 823 HLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQA-- 880
E ++ E +EK + +E+K+ + +K E ++ +K+ ++ Q + + E +
Sbjct: 592 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE--DKMQEQEEMMWEQEEKMQEQEEKMW 649
Query: 881 EIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 928
E + E+++ + K+ E++MRE E+ ++ M + +++
Sbjct: 650 EQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKM 697
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 102 bits (255), Expect = 1e-21
Identities = 116/540 (21%), Positives = 249/540 (46%), Gaps = 39/540 (7%)
Query: 348 EQAENKLMDYIDELH---KHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQ 404
+Q E + D I LH K A E E +L+ + T + K + E +K + + + +
Sbjct: 215 KQLEGEARDLISRLHDSWKFAGELEQ--ALSAVATQKKKADRYIEELTKERDALSLELYR 272
Query: 405 NEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAAD 464
N I ++ AK Q++ L E L E +++ ++A + Q+++ +A
Sbjct: 273 NTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 332
Query: 465 REIYLLRTSLHREREQAQQLHQLLALKEQEH-RKELETREFFTDADFQDALAKEIAKEEK 523
+E+ + L + E+ + ++L +E++ R+E + +E+ Q+ +E +EEK
Sbjct: 333 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE--QEEK 390
Query: 524 KHEQMIK-EYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHAL 582
EQ K QE++ ++ M + E + RR +++ E EL + H
Sbjct: 391 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 450
Query: 583 IWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKS 642
+ +E + K ++EQ+ + + +K+ ++ + +I E I + ++K
Sbjct: 451 EKIREQEEKRQEEEK-----IREQEKRQEQEAKMWRQ-----EEKIREQEEKIREQEEKM 500
Query: 643 IQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLS 702
+ E HE+ ++ E +E + E+ E+ +Q + + K+ Q E +
Sbjct: 501 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMW 560
Query: 703 RENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQ 762
R+ E + E I +Q E + + ++ ++E++E I+ +EKI E E+ TQ
Sbjct: 561 RQEEKMHDQEEK-----------IREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQ 609
Query: 763 EQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLC 822
EQ ++ Q +++ E+ E+ E++EK+++Q E ++ E K K ++ E++
Sbjct: 610 EQEEKMGEQEEKMCEQEEKMQEQEEKMRRQ----EEKIREQEKKIREQEEKIREQEEMMQ 665
Query: 823 HLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEI 882
E ++ E +EK +E+K++ + +K + EK+ + ++Q + + E HQ +
Sbjct: 666 EQEEKMWEQEEKMCEQEEKMQEQEEK----MRRQEEKMWEQEVRLRQQEEKMQE-HQEHL 720
Score = 86.3 bits (212), Expect = 1e-16
Identities = 116/541 (21%), Positives = 243/541 (44%), Gaps = 91/541 (16%)
Query: 340 EREKRWRAEQAENKLMD-YIDELHKHANEKEDIHSLAL----LTTDRLKEIIFRERNSKG 394
E E+ A + K D YI+EL K + D SL L +T + LKE + +
Sbjct: 237 ELEQALSAVATQKKKADRYIEELTK----ERDALSLELYRNTITDEELKEKNAKLQEKLQ 292
Query: 395 QLEVMVHKLQNEIKKLTVELMKAK--------DQQEDHL-KHLRTLEKTLE--------- 436
+E ++Q +K+L +L +AK + DHL K L+++ L+
Sbjct: 293 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 352
Query: 437 -KMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEH 495
++ +Q+ ++ Q IQE E K + +I + + E+ ++ +++ KE++
Sbjct: 353 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 412
Query: 496 RKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALT 555
R+ Q+ + E ++ ++ E+M+ E +EKI L ++ + E
Sbjct: 413 RR-------------QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE-------- 451
Query: 556 VEARRFQDVKDGFENVAT-ELAKSKHALIWAQRKE-NESSSLIKDLTCMVKEQKTKLAEV 613
+ R ++ + E + E + + A +W Q ++ E I++ + Q+ K+ E
Sbjct: 452 -KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQ 510
Query: 614 SKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTER 673
K+++E Q ++ E I + ++ Q E + HE+ + I + K R E
Sbjct: 511 EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKI-HEQEEKIRKQEEKM-----WRQEE 564
Query: 674 KVWGHE--LAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTE 731
K+ E + +Q + + K+ Q E + + E +R+ E + + + + +Q E
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQE----QEEKMGEQEE 620
Query: 732 TIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVL--------EKLERHN 783
+ + ++ +QE++E ++R +EKI E EK +EQ +EK + +E++ E+ E+
Sbjct: 621 KMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQ-EEKIREQEEMMQEQEEKMWEQEEKMC 679
Query: 784 ERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLK 843
E++EK+++Q K + E + E ++++ +EK + ++ L+
Sbjct: 680 EQEEKMQEQ------------------EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Query: 844 A 844
A
Sbjct: 722 A 722
Score = 77.4 bits (189), Expect = 6e-14
Identities = 74/328 (22%), Positives = 155/328 (47%), Gaps = 35/328 (10%)
Query: 603 VKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAK 662
+KE+ KL E +L + + +Q + L+ +E K Q + L+ E L EL +
Sbjct: 280 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ-QQLQAEADHLGKELQSV 338
Query: 663 ESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIK 722
+ + E ++W QQ + + K++ E + + E +R+ E
Sbjct: 339 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK-------- 390
Query: 723 CKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERH 782
I +Q E +R+ ++ + EK+E ++R +E + E E+ + Q +E + +E + +LE
Sbjct: 391 ---IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ-EEMMWEKEEKIRELEEK 446
Query: 783 NERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKL 842
+EK+++Q + K E E+IR+ K ++ + E +++E +EK +E+K+
Sbjct: 447 MHEQEKIREQ-EEKRQEEEKIRE-----QEKRQEQEAKMWRQEEKIREQEEKIREQEEKM 500
Query: 843 KAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQ 902
+ +K E +K E+ + RQ + I E ++ +K+ K+H+
Sbjct: 501 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE-----EIWRQKE--------KIHE 547
Query: 903 IEKEMRELLEETCKNKKTM---EAKIKQ 927
E+++R+ E+ + ++ M E KI++
Sbjct: 548 QEEKIRKQEEKMWRQEEKMHDQEEKIRE 575
Score = 67.0 bits (162), Expect = 8e-11
Identities = 76/387 (19%), Positives = 172/387 (44%), Gaps = 15/387 (3%)
Query: 322 QSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR 381
Q+ E+N + + Q Q+ EK WR E+ + + I E + E+E+ R
Sbjct: 343 QAQVEENELWNRLNQ--QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRR 400
Query: 382 LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ 441
+E+++ + + E M+ + + ++++ + + +++ + + + EK E+ E++
Sbjct: 401 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKR 460
Query: 442 KRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRERE----QAQQLHQLLALKEQEHRK 497
+ +++ + QE E K + +I + + E Q +++H+ ++E+E R+
Sbjct: 461 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQ 520
Query: 498 ELETREFFTDADFQDALAKEIAKEEKKHEQ--MIKEYQEKIDVLSQQYMDLENEFRIALT 555
E E E + + + ++EK HEQ I++ +EK+ ++ D E + R
Sbjct: 521 EQE--EMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEE 578
Query: 556 VEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSK 615
R+ + +++ E + + K + Q +E E ++ C +E+ + E +
Sbjct: 579 KVWRQEEKIREQEEKIREQEEKIREQEEMTQEQE-EKMGEQEEKMCEQEEKMQEQEEKMR 637
Query: 616 LKQETAANLQNQINTLEILIEDDKQKSIQIE--LLKHEKVQLISELAAKESLIFGLRTER 673
++E + +I E I + ++ + E + + E+ E +E R E
Sbjct: 638 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 697
Query: 674 KVWGHE--LAQQGSSLAQNRGKLEAQI 698
K+W E L QQ + +++ LEA I
Sbjct: 698 KMWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 31.6 bits (70), Expect = 3.6
Identities = 51/339 (15%), Positives = 136/339 (40%), Gaps = 28/339 (8%)
Query: 185 QSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDY 244
+ E + E + E K+++ ++ + + + + + EK+ + +R ++ E +
Sbjct: 379 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 438
Query: 245 GNRKECNRKVPRRSKIPYDAKTIQT---IKHHNKNYNSFVSCNRKMKPPYLKELYVSSSL 301
R E K+ + KI + Q I+ K R+ + +E +
Sbjct: 439 KIR-ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 497
Query: 302 ANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQA----------- 350
+E + +I + ++ ++ ++ E+ +E+E+ WR ++
Sbjct: 498 EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ--EEKIREQEEIWRQKEKIHEQEEKIRKQ 555
Query: 351 ENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKL 410
E K+ +++H + + ++++E + R + ++ Q + +K+
Sbjct: 556 EEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKM 615
Query: 411 TVELMKAKDQQEDHLKHLRTLEKTLEKMERQKR--QQQAAQIR----LIQEVELK----- 459
+ K +Q+E + + + EK+ Q++ ++Q +IR ++QE E K
Sbjct: 616 GEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 675
Query: 460 ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKE 498
++E + R++ + Q + L++QE + +
Sbjct: 676 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 100 bits (250), Expect = 5e-21
Identities = 144/702 (20%), Positives = 291/702 (41%), Gaps = 103/702 (14%)
Query: 307 LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHAN 366
LQ+ + + ++ ++ Q S T + V +L +E +R AE H
Sbjct: 232 LQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE---------------HER 276
Query: 367 EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK 426
+ +++ L L+E+ R K L ++ ++ L + + AK +EDH +
Sbjct: 277 QAKEL----FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHER 332
Query: 427 ---------HLRTLEKTLEKMERQ---------KRQQQAAQIRLIQEVELKASAADREIY 468
H+ LE LE+ E++ +R + A + ++ D +I
Sbjct: 333 TRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKIS 392
Query: 469 LLRTSLHREREQAQQLHQLLALKEQEHRKELETREFF-TDADFQ----DALAKEIAKEEK 523
+ L E+ Q L AL +E +E++ E + + + F + L +E++ +E
Sbjct: 393 SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEA 452
Query: 524 KHEQMIKE---YQEKIDVLSQQYMDLENEF---RIALTVEARRFQDVKDGFENVATEL-A 576
+ E++ K+ Q +I + Q+ + E + L +F D K E + L A
Sbjct: 453 QWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 512
Query: 577 KSKHALIWA----------QRKENESSSLIKDLTCMVKEQKTKLAEVSKLK--------- 617
K + A I + KE + K + M +E+ T+ E+ LK
Sbjct: 513 KEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 572
Query: 618 ----QETAANLQNQINTLEILIEDDKQ--KSIQIELLKHEKVQLISE--LAAKESLIFGL 669
Q+ NLQ Q+ E + K+ KS+Q + + E LA KE I L
Sbjct: 573 VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 632
Query: 670 RTERKVWGHELAQQGSSLAQNRGKLEAQIE----SLSRENECLRKTNESDSDALRIKCKI 725
+ +R E ++ + ++ L+ ++ LS + L E S K
Sbjct: 633 KEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK- 691
Query: 726 IDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSS-QLDEVLEKLERHNE 784
+ ++ L+ L++K E +++ ++++K + L+ ++S ++ + ++ LER
Sbjct: 692 ---KDSRLKTLEIALEQKKEECLKME---SQLKKAHEAALEARASPEMSDRIQHLEREIT 745
Query: 785 RKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKA 844
R K + + E++ + + + + +DK + + LE QVK+ +K N + K +
Sbjct: 746 R---YKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQV 802
Query: 845 ERDKSIEL-------QKNAMEKLHSMDDAFKRQVDAIVEAHQA--EIAQLANEKQKCIDS 895
E+ KS ++ + N + + D+ +++ D I E +A E Q+ E++ +
Sbjct: 803 EKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQ 862
Query: 896 ANLKVHQIEKEMRELL---EETCKNKKTMEAKIKQLAFALNE 934
EK++ ELL E+ + ++M+AK+ +L E
Sbjct: 863 EESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAE 904
Score = 75.9 bits (185), Expect = 2e-13
Identities = 125/609 (20%), Positives = 260/609 (42%), Gaps = 72/609 (11%)
Query: 302 ANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQE---REKRWRAEQAENKLMDYI 358
+N + E + + + ++V +SHS+ ++ VEQL +E +E +W E+ + K
Sbjct: 410 SNGALSTEEREEEMKQMEVYRSHSK--FMKNKVEQLKEELSSKEAQW--EELKKKAAGLQ 465
Query: 359 DELHKHANE--KEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMK 416
E+ + E ++D LAL T +L+ + + +SK +EV+ L + ++ + L
Sbjct: 466 AEIGQVKQELSRKDTELLALQT--KLETLTNQFSDSKQHIEVLKESLTAKEQRAAI-LQT 522
Query: 417 AKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHR 476
D L+ T+ K + +++ Q I +++ +R++ +L+ +
Sbjct: 523 EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN 582
Query: 477 EREQAQQLH-QLLALKEQEHRKELETREFFTD-ADFQDALAKEIAKEEKKHEQMIK---E 531
+EQ + Q+ +LKE+ + +T T ++ALA++ E+ EQ + E
Sbjct: 583 LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE 642
Query: 532 YQEKIDVLSQQYMDLENEFRIA---LTVEARRFQDVKDGFENVATELAKSKHALIWAQRK 588
QE+ID + DL+ + + L+ + D+K+ ++A+ K L K
Sbjct: 643 KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL-----K 697
Query: 589 ENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELL 648
E + K C+ E + K A + L+ + + ++I LE I K +S + +
Sbjct: 698 TLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAE 757
Query: 649 KHEKVQLISELAA----KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRE 704
++++ E+ K+ I L + K ++A + K +E R
Sbjct: 758 VDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR 817
Query: 705 NECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI-----------KRLQEK 753
+ L +++ D+LR K I++ E +R+ E++ + K+++E
Sbjct: 818 EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL 877
Query: 754 ITEIEKC-------------TQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVEL 800
+ +EK TQ+ L EK + L + + +H E ++KQ
Sbjct: 878 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQ--------- 928
Query: 801 EEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSI-ELQKNAMEK 859
E + A S +K + LE + K+K + + LK E+D+ + +L++ +
Sbjct: 929 EALLAAIS-------EKDANIALLE--LSSSKKKTQEEVAALKREKDRLVQQLKQQTQNR 979
Query: 860 LHSMDDAFK 868
+ M D ++
Sbjct: 980 MKLMADNYE 988
Score = 43.9 bits (102), Expect = 7e-04
Identities = 64/304 (21%), Positives = 125/304 (41%), Gaps = 44/304 (14%)
Query: 201 EIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKR-------DTDITSESDYGNRKECNRK 253
EI L++ ++ L++ ++ + + LE P+ + +IT D ++ + +
Sbjct: 700 EIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQA--E 757
Query: 254 VPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKP 313
V R +I K ++ K N R++K K +AN ++ EK
Sbjct: 758 VDRLLEI---LKEVENEK--NDKDKKIAELERQVKDQNKK-------VANLKHKEQVEKK 805
Query: 314 KTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHS 373
K+ + + EDN S + D R+K R E+ E L + +
Sbjct: 806 KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ-------------- 851
Query: 374 LALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEK 433
+T +R + ++ +E +++ E V +L ++K+ EL K + + L E
Sbjct: 852 ---ITAER-EMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET 907
Query: 434 TLEKMERQKRQQQAAQIRLIQEVELKA-SAADREIYLLRTSLHREREQAQQLHQLLALKE 492
L + ++R+ + + QE L A S D I LL S +++ Q ++ ALK
Sbjct: 908 HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQ----EEVAALKR 963
Query: 493 QEHR 496
++ R
Sbjct: 964 EKDR 967
Score = 41.2 bits (95), Expect = 0.005
Identities = 63/295 (21%), Positives = 117/295 (39%), Gaps = 65/295 (22%)
Query: 694 LEAQIESLSRENECLRKTNESD---------------SDALRIKCKIIDDQTETIRKLKD 738
L+ Q++ + REN+ LRK E S L+ + + D+ I K+
Sbjct: 154 LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE 213
Query: 739 ---CLQEKDEHIK----------RLQEKITEI----------EKCTQEQLDEKSSQLDEV 775
+QE+++H++ R+Q + ++ E C E +E +L
Sbjct: 214 QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273
Query: 776 LEK-----------LERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKW---------H 815
E+ LE R E KQ L ++ E I+K L K H
Sbjct: 274 HERQAKELFLLRKTLEEMELRIETQKQTLNARD---ESIKKLLEMLQSKGLSAKATEEDH 330
Query: 816 DKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAME--KLHSMDDAFKRQVDA 873
++ L E V ++ E KEK+ R++ +NA + K ++ + + D+
Sbjct: 331 ERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK-DS 389
Query: 874 IVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQL 928
+ + + + L E Q + L + E+EM++ +E + K M+ K++QL
Sbjct: 390 KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ-MEVYRSHSKFMKNKVEQL 443
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 100 bits (250), Expect = 5e-21
Identities = 164/753 (21%), Positives = 315/753 (41%), Gaps = 74/753 (9%)
Query: 226 LEKDPRPKRDTDITSESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNR 285
+E + K+ + SE D + + + K + A T KH N+ V+
Sbjct: 1733 MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTN---VTEEG 1789
Query: 286 KMKPPYLKELYVSSSLANCPMLQES----EKPKTEIIKVDQSHSEDNTYQSLVEQLDQER 341
P E S S++ P ES + + K SH E N Y ++Q+DQ +
Sbjct: 1790 TQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNY---LQQIDQLK 1846
Query: 342 EKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVH 401
E+ E+ + K ++ L NEK + S LK + +E +K + ++
Sbjct: 1847 ERIAGLEEEKQKNKEFSQTLE---NEKNTLLSQISTKDGELK--MLQEEVTK--MNLLNQ 1899
Query: 402 KLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKAS 461
++Q E+ ++T A+++++D LE+ L + + + + ++K
Sbjct: 1900 QIQEELSRVTKLKETAEEEKDD-------LEERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
Query: 462 AADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKE-LETREFFTDADFQDALAKEIAK 520
+ E+ L+ + E+ QQL + E E RKE LE + + AKE+ +
Sbjct: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE 2012
Query: 521 EEKKHEQMIKE-------YQEKIDVLSQQYMDLE---NEFRIALTVEARRFQDVKDGFEN 570
K+ +Q +K+ YQEKI L + LE E + L + + +
Sbjct: 2013 LLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKK 2072
Query: 571 VATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINT 630
ELA K L ++E++ ++ D + KE ++ V ++ +L+ ++
Sbjct: 2073 AQAELASFKVLL---DDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129
Query: 631 LEIL-IEDDKQKSIQIELLKHEKVQL---ISELAA----KESLIFGLRTERKVWGHELAQ 682
E +++ K +++ L+ EKV L I E+ K+ + L+ +LA
Sbjct: 2130 AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAA 2189
Query: 683 QGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIK---CKIIDDQTETIRKLKDC 739
S++ + + I+ + +S + +R+K C ++ DQ +R++
Sbjct: 2190 FTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQ---LRQMSIH 2246
Query: 740 LQEKDEHIKRLQ--EKITEIEKCTQEQLDEK-----SSQLDEVLEKLER-----HNERKE 787
++E +I RL+ ++I E + T+ QL +K + E+L +LE H+ + E
Sbjct: 2247 MEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNE 2306
Query: 788 --KLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAE 845
KL+ +LK + +L ++ + + + ++ E ++ K +E E L+A
Sbjct: 2307 LAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQAS 2366
Query: 846 RDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEK 905
R EL E+++ + + EA Q IA+L + K I + Q E+
Sbjct: 2367 R----ELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEE 2422
Query: 906 EMRELLEETCKNKKTMEAKIKQLAFALNEIQQD 938
E L EE NKK ++ K QL L I+++
Sbjct: 2423 ENIVLEEE---NKKAVD-KTNQLMETLKTIKKE 2451
Score = 89.7 bits (221), Expect = 1e-17
Identities = 167/795 (21%), Positives = 342/795 (43%), Gaps = 110/795 (13%)
Query: 199 QNEIKLQKLDDQILQLLNETSNSIDNVLE--KDPRPKRDTDITSESDYGNRKECNRKVPR 256
Q E++ ++ D++I QL E E ++ R K+ ++ +RKE ++
Sbjct: 1442 QLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKS 1501
Query: 257 -RSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKT 315
+ ++ TI+ + + S VS K K L L +LQE E+ K
Sbjct: 1502 LQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRL---------ALLQE-ERDKL 1551
Query: 316 EIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHK----HANEKEDI 371
I ++D+S E+ + S E L E + + KL+ I+ L + E ++
Sbjct: 1552 -ITEMDRSLLENQSLSSSCESLKLALEG---LTEDKEKLVKEIESLKSSKIAESTEWQEK 1607
Query: 372 HSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTL 431
H + L + N +++ +V ++ E ++L +L + +++ K L+
Sbjct: 1608 HKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA 1667
Query: 432 EKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLL--- 488
E+ +E+M+ + R+ ++ + I E+E E LR +H + A++ + L
Sbjct: 1668 EQEMEEMKEKMRKFAKSKQQKILELE-------EENDRLRAEVHPAGDTAKECMETLLSS 1720
Query: 489 --ALKEQEHRKELE----TREFFTDADFQDALAKEIAKEEKKHE-------QMIKEYQEK 535
++KE+ R ++E +++F + +D+L++E+ ++ KH+ Q E EK
Sbjct: 1721 NASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEV--QDLKHQIEGNVSKQANLEATEK 1778
Query: 536 IDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSL 595
D ++ E ++ E + +E S + A K+ S
Sbjct: 1779 HD----NQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDE 1834
Query: 596 IKDLTCMVKEQKTKLAEVSKLKQ---ETAANLQNQINTL--EILIEDDKQKSIQIELLKH 650
I + + + K ++A + + KQ E + L+N+ NTL +I +D + K +Q E+ K
Sbjct: 1835 INNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM 1894
Query: 651 EKV--QLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKL-----EAQIESLSR 703
+ Q+ EL+ L E+ L Q + L + G +AQI++
Sbjct: 1895 NLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELL 1954
Query: 704 ENE------CLRKTNESDSDALRIKCKIIDD-----------------QTETIRKLKDCL 740
E+E C+ + E ++ K K+ + ++L++ L
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELL 2014
Query: 741 QEKDEHIKRLQ-------EKITEIEKCTQEQLD----EKSSQLDEVLEKLERHNERKEKL 789
+EK + +K+LQ EKI+ +E+ T + L+ E L+ E L + E ++K
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALER-TVKALEFVQTESQKDLEITKENLAQAVEHRKKA 2073
Query: 790 KQQLKGKEVELEEIR-KAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDK 848
+ +L +V L++ + +A L K EL + E+ ++K+K E+ E++L+ +K
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Query: 849 SIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMR 908
++ +KN EKL DA +R+ + + + E Q ++ + +V Q+++ +
Sbjct: 2134 HLKEKKNMQEKL----DALRRE--------KVHLEETIGEIQVTLNKKDKEVQQLQENLD 2181
Query: 909 ELLEETCKNKKTMEA 923
+ + K+M +
Sbjct: 2182 STVTQLAAFTKSMSS 2196
Score = 87.8 bits (216), Expect = 4e-17
Identities = 119/543 (21%), Positives = 227/543 (41%), Gaps = 64/543 (11%)
Query: 399 MVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVEL 458
+ H QNE+ KL EL KDQ D L +LEK + QK + I QE ++
Sbjct: 2299 LYHSSQNELAKLESELKSLKDQLTD-------LSNSLEKCKEQKGNLEG--IIRQQEADI 2349
Query: 459 KASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEI 518
+ S E L T L RE +LH+ + +KEQ+ L +E +A+ I
Sbjct: 2350 QNSKFSYE--QLETDLQASRELTSRLHEEINMKEQKIISLLSGKE--------EAIQVAI 2399
Query: 519 AKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKS 578
A+ ++H++ IKE + + ++ + LE E + A+ + + +K + + A+
Sbjct: 2400 AELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQL 2459
Query: 579 KHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAA---NLQNQINTLEILI 635
+ +N+ ++ D + + + + E +L QE AA L+ +I L +
Sbjct: 2460 DSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHM 2519
Query: 636 ED--DKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGK 693
+D + + EL+++ + L + K+S ++K QQ L K
Sbjct: 2520 DDLNSENAKLDAELIQYRE-DLNQVITIKDS-------QQKQLLEVQLQQNKELENKYAK 2571
Query: 694 LEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEK 753
LE +++ NE LR++ + + + D ++ I LK + + + LQE+
Sbjct: 2572 LEEKLKESEEANEDLRRSFNALQEEKQ-------DLSKEIESLKVSISQLTRQVTALQEE 2624
Query: 754 IT-----EIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYS 808
T K +E++ S+ +++ E ++++ K E+E+ K
Sbjct: 2625 GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED--KLKK 2682
Query: 809 TLNRKWHDKGELLCHLET---QVKEVKEKFENKEKKL----KAERDKSIELQK--NAMEK 859
L HD G + ET +V E+ E+KL K + + ++Q +M
Sbjct: 2683 ELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS 2742
Query: 860 LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKK 919
L + D ++D + + A + +LA K++ + + +E LL ET +
Sbjct: 2743 LQNSRDHANEELDELKRKYDASLKELAQLKEQGL---------LNRERDALLSETAFSMN 2793
Query: 920 TME 922
+ E
Sbjct: 2794 STE 2796
Score = 81.3 bits (199), Expect = 4e-15
Identities = 98/476 (20%), Positives = 209/476 (43%), Gaps = 42/476 (8%)
Query: 400 VHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELK 459
V +LQ +I K +E+ K + H +L++ LE Q Q A + ++E++ K
Sbjct: 1339 VFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESS-----QLQIAGLEHLRELQPK 1393
Query: 460 ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIA 519
L+ + ++ E L L+ KE K ++T E D AL ++
Sbjct: 1394 LDE-------LQKLISKKEEDVSYLSGQLSEKEAALTK-IQT-EIIEQEDLIKALHTQLE 1444
Query: 520 KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEAR-------RFQDVKDGFENVA 572
+ K+H++ IK+ Q ++ + Q+ ++ E R ++ + R + +K+ +++
Sbjct: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN-KSLQ 1503
Query: 573 TELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTL- 631
EL+ ++ + +R + + ++ KE+ T L ++ L++E + +L
Sbjct: 1504 EELSLARGTI---ERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL 1560
Query: 632 --EILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQ 689
+ L + + +E L +K +L+ E+ + +S TE + EL ++ L Q
Sbjct: 1561 ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ 1620
Query: 690 NRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRK-LKDCLQEKDEHIK 748
+ + + E + E +R+ + LR TE +K + LQE ++ ++
Sbjct: 1621 SYENVSNEAERIQHVVEAVRQEKQELYGKLR--------STEANKKETEKQLQEAEQEME 1672
Query: 749 RLQEKITEIEKCTQEQLDEKSSQLDEVLEKL----ERHNERKEKLKQQLKGKEVELEEIR 804
++EK+ + K Q+++ E + D + ++ + E E L + ELE ++
Sbjct: 1673 EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK 1732
Query: 805 KAYSTLNRKWHDKGELLCHLETQVKEVKEKFE-NKEKKLKAERDKSIELQKNAMEK 859
Y TL++K+ L +V+++K + E N K+ E + + Q N E+
Sbjct: 1733 MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEE 1788
Score = 75.5 bits (184), Expect = 2e-13
Identities = 167/822 (20%), Positives = 344/822 (41%), Gaps = 126/822 (15%)
Query: 199 QNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRS 258
Q E+++ K+D +L+ + + EKD + +E + ++ + +
Sbjct: 870 QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQ-------VTEISFSMTEKMVQLNEEKF 922
Query: 259 KIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEII 318
+ + KT++ + N K ++ VSS L + P +I
Sbjct: 923 SLGVEIKTLK------EQLNLLSRAEEAKKEQVEEDNEVSSGL---KQNYDEMSPAGQIS 973
Query: 319 KVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENK-LMDYIDELHKH-ANEKEDIHSLAL 376
K + H D L+++ +++R+++ +A K L+ + L + AN K++
Sbjct: 974 KEELQHEFD-----LLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIP 1028
Query: 377 LTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLR-TLE--- 432
L+ E+ + N + + + K Q ++ + L + ++E L+H+R LE
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQ----EIEIYLKQTISEKEVELQHIRKDLEEKL 1084
Query: 433 ------KTLEKMERQKRQQQAAQIRLIQE------------VELKASAADRE-IYLLRTS 473
+ L K Q Q + QI L+Q + A+D + + L++ +
Sbjct: 1085 AAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKET 1144
Query: 474 L--------HREREQAQQLHQLLALKEQEHRKELETREFFTD--ADFQDALAKE--IAKE 521
+ E + + ++LAL++++ + + + +E T A + A KE + +E
Sbjct: 1145 VVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREE 1204
Query: 522 EKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVK-------------DGF 568
K+ + QE+ D S++ ++ ++ R L ++ R D K G
Sbjct: 1205 LKQQKDDYNRLQEQFDEQSKENENIGDQLR-QLQIQVRESIDGKLPSTDQQESCSSTPGL 1263
Query: 569 ENVATELAKSKHAL---------IWAQRKENESS----SLIKDLTCMVKEQKTKLAEVSK 615
E + + H W E+ S+ + + + +KE + + E+
Sbjct: 1264 EEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELEL 1323
Query: 616 LKQETAANLQNQINTLEILIEDDKQKSIQIELLK---HE----KVQLISELAAKESLIFG 668
T + L + + L E ++ ++IE LK HE L +L + + I G
Sbjct: 1324 KVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAG 1383
Query: 669 LRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDD 728
L R EL + L + K E + LS + +E ++ +I+ +II +
Sbjct: 1384 LEHLR-----ELQPKLDELQKLISKKEEDVSYLSGQ------LSEKEAALTKIQTEII-E 1431
Query: 729 QTETIRKLKDCLQ----EKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERH-N 783
Q + I+ L L+ E DE IK+LQ ++ E+ K E++ E+S ++ KL+
Sbjct: 1432 QEDLIKALHTQLEMQAKEHDERIKQLQVELCEM-KQKPEEIGEESRAKQQIQRKLQAALI 1490
Query: 784 ERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLK 843
RKE LK+ K ++ EE+ A T+ R ++ + Q KE K+ + L+
Sbjct: 1491 SRKEALKE---NKSLQ-EELSLARGTIERLTKSLADVESQVSAQNKE-KDTVLGRLALLQ 1545
Query: 844 AERDKSI-ELQKNAME--KLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSA---N 897
ERDK I E+ ++ +E L S ++ K ++ + E + + ++ + K I +
Sbjct: 1546 EERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQ 1605
Query: 898 LKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 939
K +++KE E+L ++ +N +I+ + A+ + +Q++
Sbjct: 1606 EKHKELQKEY-EILLQSYENVSNEAERIQHVVEAVRQEKQEL 1646
Score = 73.9 bits (180), Expect = 6e-13
Identities = 146/760 (19%), Positives = 319/760 (41%), Gaps = 128/760 (16%)
Query: 199 QNEIKLQK-----LDDQILQLLNETSNSIDNV--LEKDPR---PKRDTDITSESDYGNRK 248
+ EI+L++ L DQ+ Q+ N+ LE D + K T++ + +K
Sbjct: 2223 EEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQ-----QK 2277
Query: 249 ECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQ 308
C+ ++ + + + H ++N + + K L +L S+SL C +
Sbjct: 2278 VCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL--SNSLEKC---K 2332
Query: 309 ESEKPKTEIIKVDQSHSEDN--TYQSLVEQLDQEREKRWRAEQAENKLMDYIDEL----- 361
E + II+ ++ +++ +Y+ L L RE R + N I L
Sbjct: 2333 EQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKE 2392
Query: 362 -----------HKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKL 410
+H E +++ +L L+ + + I+ E N K + ++L +K +
Sbjct: 2393 EAIQVAIAELRQQHDKEIKELENL--LSQEEEENIVLEEENKKAVDKT--NQLMETLKTI 2448
Query: 411 TVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQI-------RLIQEVELKASAA 463
E ++ K Q + +K + +L+ +++ +Q + + +LIQE + +
Sbjct: 2449 KKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKL 2508
Query: 464 DREIYLLRT---SLHRER--------EQAQQLHQLLALKEQEHRKELETREFFTDADFQD 512
EI LR+ L+ E + + L+Q++ +K+ + ++ LE + + + ++
Sbjct: 2509 KEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV-QLQQNKELEN 2567
Query: 513 ALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEF---RIALTVEARRFQDVKD--- 566
AK + ++ K+ E+ ++ + + L ++ DL E +++++ R+ +++
Sbjct: 2568 KYAK-LEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626
Query: 567 -GFENVATELAKSKHALIWA--QRKENESSSLIKDLTCMVKEQKTKLAEVS-KLKQET-- 620
G + ++ + + + A + + L ++L C+ KE K+ E+ KLK+E
Sbjct: 2627 LGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKH 2686
Query: 621 ----AANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVW 676
A ++N+ T E + + + +++E +K+ +++ KE+ GL + + +
Sbjct: 2687 LHHDAGIMRNETETAEERVAELARDLVEME----QKLLMVT----KENK--GLTAQIQSF 2736
Query: 677 GHELAQQGSSLAQNRGKLEAQIESLSRENEC----LRKTNES-----DSDALRIKCKIID 727
G + SSL +R +++ L R+ + L + E + DAL +
Sbjct: 2737 GRSM----SSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSM 2792
Query: 728 DQTET-----IRKLKDCLQEKDEHIKRLQEKITEIEKCTQE------QLDEKSSQLDEVL 776
+ TE + KL L KDE + L ++ + Q L + L L
Sbjct: 2793 NSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNEL 2852
Query: 777 EKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLE----------- 825
EK + E K++ Q E++ ++KA S+L +D+ LL L+
Sbjct: 2853 EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQ---NDRDRLLKELKNLQQQYLQINQ 2909
Query: 826 --TQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSM 863
T++ +K + + + K KA + EL++ + H +
Sbjct: 2910 EITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHEL 2949
Score = 71.6 bits (174), Expect = 3e-12
Identities = 160/827 (19%), Positives = 336/827 (40%), Gaps = 117/827 (14%)
Query: 199 QNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRS 258
Q +++LQ+ D+ L E + DN ++K + +TS + Y K +
Sbjct: 70 QKDVQLQQKDEA----LQEERKAADNKIKK-LKLHAKAKLTSLNKYIEEM----KAQGGT 120
Query: 259 KIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYL-KELYVSSSLANCPMLQ-----ESEK 312
+P + ++ + + H+K+ K+K KE +S+ A Q +S
Sbjct: 121 VLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSST 180
Query: 313 PKTEIIKVDQSHSEDNTYQSLVE-QLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDI 371
E + + Q E + S ++ QL Q + ++ + K + ++ H +E +
Sbjct: 181 EMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL 240
Query: 372 HSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTL 431
+ A + T+ +++ +R + E +V + Q + L EL A+ + + + L+ +
Sbjct: 241 VTQADVETEMQQKLRVLQRKLEEHEESLVGRAQ-VVDLLQQELTAAEQRNQILSQQLQQM 299
Query: 432 EKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLA-- 489
E + ++ L++++EL+ + + L+ +H EQ +Q Q A
Sbjct: 300 EAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAEL 359
Query: 490 -----LKEQEHRKELETREFF------TDADFQ---DALAKEIAKE-EKKHEQMIKEYQE 534
EQ+H+ E+E + T + Q DAL + +K + K+EQ ++ Q
Sbjct: 360 ESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQT 419
Query: 535 KIDVLSQQYMDLENEF-----RIAL----TVEARRFQDV-KDGF-----ENVAT------ 573
I L Q E R+ L T F DV +G EN+A+
Sbjct: 420 -IQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVV 478
Query: 574 ELAKSKHALIWA----QRKENESSSLIKDLTCMVKEQKTKLA--EVSKLKQETAANLQN- 626
EL K AL+ + + + E+ L +T + + +T A EVS++ AN ++
Sbjct: 479 ELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSS 538
Query: 627 --QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQ- 683
+ + ++L QK ++ +L E + E+A + + G R E HE+ Q
Sbjct: 539 SAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEA--DHEVLDQK 596
Query: 684 ------GSSLAQNRGKL---------------EAQIESLSRENECL----RKTNESDSDA 718
G +A + K+ E+ + ++ +E R + E +
Sbjct: 597 EMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLND 656
Query: 719 LRIKCKII-DDQTETIRKLKDCLQEKDEHIKRLQEKITEIE-------KCTQEQLDEKSS 770
++ K D +++ + D Q + ++RL+ +I E+E + ++ LDEK+
Sbjct: 657 AGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAK 716
Query: 771 QLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKE 830
++ + + +E + + E +++ L+ ++ L QVK+
Sbjct: 717 EISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELS--------MVTELRAQVKQ 768
Query: 831 VKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLA---N 887
++ E++ + + + E++HS+ K + D +E Q E+ + +
Sbjct: 769 LEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSK-DVKIEVLQNELDDVQLQFS 827
Query: 888 EKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNE 934
E+ I S ++ E E+ E E + + +K+++L+ AL++
Sbjct: 828 EQSTLIRSLQSQLQNKESEVLEGAERV----RHISSKVEELSQALSQ 870
Score = 62.8 bits (151), Expect = 1e-09
Identities = 115/636 (18%), Positives = 262/636 (41%), Gaps = 71/636 (11%)
Query: 332 SLVEQLDQEREKRWRAEQAENKL--------MDYIDELHKHANEKEDIHSLALLTTDRLK 383
S V++L E R + +Q E L +DY + E IHSL++ +
Sbjct: 751 SQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDV 810
Query: 384 EIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKR 443
+I + N +++ + I+ L +L + + + + +R + +E++ Q
Sbjct: 811 KIEVLQ-NELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS-QAL 868
Query: 444 QQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQL-----HQLLALKEQEHRKE 498
Q+ +I + ++ L+ R++ L+ ++ + +Q ++ +++ L E++
Sbjct: 869 SQKELEITKMDQLLLEKK---RDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLG 925
Query: 499 LETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEA 558
+E + + +++ E+ ++ ++E E L Q Y ++ +I+
Sbjct: 926 VEIKTLKEQLNL-------LSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQ 978
Query: 559 RRFQDVKDGFEN----VATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVS 614
F +K E + L K L R E E ++L + + +T+ EV
Sbjct: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVE 1038
Query: 615 KLKQETAAN---LQNQINTLEILIEDD-KQKSIQIELLKHEKVQLISELAAKESLIFGLR 670
+ K+ + + ++ +EI ++ +K ++ L+H + L +LAA+E
Sbjct: 1039 EDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVE---LQHIRKDLEEKLAAEEQF----- 1090
Query: 671 TERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECL------RKTNESDSDALRIKCK 724
L +Q + Q++ +++ EN+ + T+ SD D++ +
Sbjct: 1091 -------QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALV-- 1141
Query: 725 IIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEK----LE 780
ET+ C + L+EKI +EK +EQL +K L E L L+
Sbjct: 1142 -----KETVVISPPCTGSSEHWKPELEEKILALEK-EKEQLQKK---LQEALTSRKAILK 1192
Query: 781 RHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKE-VKEKFENKE 839
+ E++ L+++LK ++ + +++ + +++ + G+ L L+ QV+E + K + +
Sbjct: 1193 KAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD 1252
Query: 840 KKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLK 899
++ +E + H + + +H + + L A LK
Sbjct: 1253 QQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLK 1312
Query: 900 VHQIEKEMRELLEETCKNKKTMEA-KIKQLAFALNE 934
+ EK EL + ++ T ++ ++ QL +N+
Sbjct: 1313 EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINK 1348
Score = 59.7 bits (143), Expect = 1e-08
Identities = 100/548 (18%), Positives = 218/548 (39%), Gaps = 84/548 (15%)
Query: 454 QEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDA 513
++V+ + + A++ + L+ + ++ Q QQ + L QE RK + +
Sbjct: 48 EDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL----QEERKAADNK----------- 92
Query: 514 LAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIAL-------TVEARRFQDVKD 566
K++ K + +Y E++ + E + L T E + +K
Sbjct: 93 -IKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKH 151
Query: 567 GFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQN 626
+ ++ + L AQ ++ SS + M+K+Q + E Q + Q
Sbjct: 152 KLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQA 211
Query: 627 QINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRT-ERKVWGHE------ 679
+ +++ E D + Q+ L + E +QL+++ + + LR +RK+ HE
Sbjct: 212 EQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGR 271
Query: 680 -----LAQQGSSLAQNRGK-LEAQIESLSRENECLRKTNESDSDALRIKCKIID------ 727
L QQ + A+ R + L Q++ + E+ LR T E++ + +I + ++
Sbjct: 272 AQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAER 331
Query: 728 ---------------DQTETI---------------RKLKDCLQEKDEHIKRLQEKITEI 757
+Q E +K K ++EK HI LQ+ E+
Sbjct: 332 KLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQEL 391
Query: 758 EKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDK 817
+ D+ S L + E+ + + ++L+ QL+ K +EI + + L + H+
Sbjct: 392 QSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKS---KEISQFLNRLPLQQHET 448
Query: 818 GELLCHLE-----TQVKEVKEKFENKEKKLKAERDK-SIELQKNAMEKLHSMDDAFKRQV 871
+ TQ + +++ ++ E +K ++ L +E+L + ++ Q+
Sbjct: 449 ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQI 508
Query: 872 DAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFA 931
+ ++ A + +D AN + E+ +++LE T K ++ L
Sbjct: 509 TLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQK---HKELSVLLLE 565
Query: 932 LNEIQQDM 939
+ E Q+++
Sbjct: 566 MKEAQEEI 573
Score = 56.6 bits (135), Expect = 1e-07
Identities = 163/848 (19%), Positives = 333/848 (39%), Gaps = 127/848 (14%)
Query: 131 LDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVCQSSEPE 190
L+NL+S + NI +E + T + E + + + A L SF+ S + +
Sbjct: 2413 LENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND 2472
Query: 191 KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKEC 250
++ D Q +L+++ L ++ E I ++ + K E G R
Sbjct: 2473 RDRIVGDYQ------QLEERHLSIILEKDQLIQEAAAENNKLK-------EEIRGLRSHM 2519
Query: 251 NRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLK-ELYVSSSLANCPMLQE 309
+ +K+ DA+ IQ + ++ N ++ + L+ +L + L N E
Sbjct: 2520 DDLNSENAKL--DAELIQ----YREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLE 2573
Query: 310 SEKPKTEIIKVDQSHSEDNTYQSLVEQLDQERE----------KRWRAEQAENKLMDYID 359
+ ++E D S N Q + L +E E ++ A Q E L Y
Sbjct: 2574 EKLKESEEANEDLRRSF-NALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHA 2632
Query: 360 ELHKHANEKEDIHSLALLTTDRLK-------EIIFRERNSKGQLEVMVHKLQNEIKKLTV 412
+L ++E++H L+ L + K E++ ++ + ++ + KL+ E+K L
Sbjct: 2633 QLKV---KEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHH 2689
Query: 413 ELMKAKDQQEDHLKHLRTLEKTLEKMERQ------KRQQQAAQI----RLIQEVELKASA 462
+ +++ E + + L + L +ME++ + + AQI R + ++
Sbjct: 2690 DAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDH 2749
Query: 463 ADREIYLLRTSLHREREQAQQLHQLLALKEQ----EHRKELETREFFTDADFQDALAKEI 518
A+ E+ L+ R+ L +L LKEQ R L + F+ ++ +
Sbjct: 2750 ANEELDELK------RKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHL 2803
Query: 519 AKEEK----KHEQMI------KEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGF 568
K + K EQ++ ++ ++ S+ L+NE R L E +F+ ++G
Sbjct: 2804 EKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE-RDHLWNELEKFRKSEEGK 2862
Query: 569 ENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQI 628
+ A + + S + Q + SSL D ++KE K + ++ QE ++
Sbjct: 2863 QRSAAQPSTSPAEV---QSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT-----EL 2914
Query: 629 NTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQ---QGS 685
+ L+ +++ + K+ ++++ E LR E W HEL Q + S
Sbjct: 2915 HPLKAQLQEYQDKTKAFQIMQEE-----------------LRQENLSWQHELHQLRMEKS 2957
Query: 686 SLAQNRGKLEAQI--------ESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLK 737
S + +++ Q + LS +R+ S S +K + +
Sbjct: 2958 SWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASP 3017
Query: 738 DCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKE 797
D Q + L+ ++ + K ++ +K ++ ++ + E K L QL
Sbjct: 3018 DGSQNLVYETELLRTQLNDSLK----EIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTS 3073
Query: 798 VELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFE---NKEKKLKAERDKSIELQK 854
L E ++ Y G+LL H K+V+E N + A ++K+ +K
Sbjct: 3074 QSLRENQQHY----------GDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRK 3123
Query: 855 NAMEKLHSMDDAFKRQVDAIVEAHQA--EIAQLANEKQKCIDSANLKVHQIEKEMRELLE 912
+ E+L +F + Q E+ +L E++ +A + E+++R L
Sbjct: 3124 SDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLEH 3183
Query: 913 ETCKNKKT 920
+ +T
Sbjct: 3184 SEWDSSRT 3191
Score = 50.8 bits (120), Expect = 6e-06
Identities = 65/319 (20%), Positives = 138/319 (43%), Gaps = 41/319 (12%)
Query: 620 TAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHE 679
T ++Q ++ E L+ + K ++++ + VQL + A L+ ERK ++
Sbjct: 46 TQEDVQERLAYAEQLVVELK------DIIRQKDVQLQQKDEA-------LQEERKAADNK 92
Query: 680 LAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDC 739
+ + L IE + + + T + L K ++ I K+K
Sbjct: 93 IKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHK 152
Query: 740 LQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKE---KLKQQLKGK 796
LQEK+E I LQ ++T+ + EQ + S++++E + ++ E++E L+ QL
Sbjct: 153 LQEKEELISTLQAQLTQAQ---AEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQT 209
Query: 797 EVE------LEEIRKAYSTLNRKWHD-------KGELLCHLETQVKEVKEKFENKEKKL- 842
+ E + E + T R D + ++ ++ +++ ++ K E E+ L
Sbjct: 210 QAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLV 269
Query: 843 -KAERDKSIELQKNAMEKLHSMDDAFKRQVDA-------IVEAHQAEIAQLANEKQKCID 894
+A+ ++ + A E+ + + +Q++A VE + E L + + +
Sbjct: 270 GRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVA 329
Query: 895 SANLKVHQIEKEMRELLEE 913
L H +++EM LLE+
Sbjct: 330 ERKLSFHNLQEEMHHLLEQ 348
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 100 bits (249), Expect = 6e-21
Identities = 167/839 (19%), Positives = 337/839 (40%), Gaps = 114/839 (13%)
Query: 177 LTSFMSVCQSSEPEKNNHENDLQNEIKLQKL------------DDQILQLLNETSNSIDN 224
L + + C+S++ ++ +N+L +++ K D+QI QL + +
Sbjct: 433 LEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKR 492
Query: 225 VLEKDPRPKR--------DTDITSESDYGNRK--ECNRKVPRRSKIPYDAKTIQTIKHHN 274
+ E + + K+ +TSE+ GN + E + + K+ Y+ + + K N
Sbjct: 493 MYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRN 552
Query: 275 --KNYNSFVSCNRKMKPPYLKE-LYVSSSLANCPMLQESEKPKTEIIKVDQSHSE----- 326
K V ++ + ++E + L+ C M E EK ++ +++ E
Sbjct: 553 QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM--EREKKGRKVTEMEGQAKELSAKL 610
Query: 327 ---------DNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLAL- 376
+N SL +++++ +K E+ K + I +L + E E++ +
Sbjct: 611 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR---ELENVKAKLAQ 667
Query: 377 -LTTDRLKEIIFRERNSKGQLEVMVHKL-------QNEIKKLTVELMKAKDQQEDHLKHL 428
+ + +++ R G+L + +L Q EI+K+ ++ K+Q + +
Sbjct: 668 HVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEM 727
Query: 429 RTLEKTLEKMERQKRQQQAA---QIRLIQEVELKASAADREIYLLRTSLHREREQAQQLH 485
+ L+ E K+ A R + +V K + E+ L + +L
Sbjct: 728 KNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLE 787
Query: 486 QLLALKEQEHRKELETREFFTDADFQ-DALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYM 544
+ E+ ++ + + + Q L K+ ++++K + E ++S QY+
Sbjct: 788 TVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYV 847
Query: 545 DLENEFRIALTVEA------RRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKD 598
++ + +T+ R DVK FE++ E K K +R + + IK
Sbjct: 848 PVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA 907
Query: 599 LTCMVKEQKTKLAEVSKLKQ-------ETAANL---QNQINTLEILIEDDKQKSIQI-EL 647
+ E + K++ +S+ + E AN Q +I TL I+ K++ I E
Sbjct: 908 EYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEC 967
Query: 648 LKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC 707
+K + ++S + K EL Q S Q E +++ +EN+
Sbjct: 968 IKVKYAPIVSFEECERKF--------KATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK 1019
Query: 708 LRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDE 767
L+K + LR K +I+ E R L E ++ +K L +K TE++ ++ ++E
Sbjct: 1020 LKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEE 1079
Query: 768 KSSQLDEVL----------------EKLERH-NERKEKLKQQLKGK----EVELEEIRKA 806
+ Q E+L E L++ N E LK++LK E E + + K
Sbjct: 1080 NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1139
Query: 807 YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 866
+ L + + L HL ++KE FE + +KA + E +N ME++ +
Sbjct: 1140 HQLLENQKNSSVPLAEHL-----QIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSE 1194
Query: 867 FKRQVDAIVEAHQAEIAQLANEK------QKCIDSANLKVHQIEKEMRELLEETCKNKK 919
+ A+ + E+ L+ K + I S N K+ + ++ E+ EE KK
Sbjct: 1195 VQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKK 1253
Score = 70.9 bits (172), Expect = 5e-12
Identities = 137/714 (19%), Positives = 287/714 (40%), Gaps = 112/714 (15%)
Query: 318 IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALL 377
+ V E Q L + + +E+ + +Q + L+D ++ L NE+ +
Sbjct: 271 VNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLES 330
Query: 378 TTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEK 437
++LK ++ + + + L+N K + + + + + + + +
Sbjct: 331 EREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYM 390
Query: 438 MERQ-------KRQQQAAQIRLIQEVELKASAA-------DREIYLLRTSLHREREQAQQ 483
+ Q Q + +R + E+ L + + +E+ +RT ++ +
Sbjct: 391 ADSQCTSPGIPAHMQSRSMLRPL-ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLK 449
Query: 484 LHQLLALKEQEHRK-ELETREFFTDAD-----FQDALAKEIAKEEKKHEQMIKEYQEKID 537
L LA K E + LE D+D +DAL K++ K + E +K+ Q
Sbjct: 450 LQNELAHKVAECKALALECERVKEDSDEQIKQLEDAL-KDVQKRMYESEGKVKQMQTHFL 508
Query: 538 VLSQQYMDLENEFRIALTVEAR-RFQDVKDGFENVATELAK-----SKHALIWAQRKEN- 590
L + LT E + + +D+K +E + E+ K ++ +I + K +
Sbjct: 509 ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDE 568
Query: 591 -----ESSSLIKDLTCMVKEQKTKLAEVSKLKQET------------AANLQNQINTLEI 633
E+ L K+L+ E++ K +V++++ + A +N ++L
Sbjct: 569 GKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSN 628
Query: 634 LIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTE--RKVWGHELAQQGSSLAQNR 691
+ + +K +++E +HEK +SE+ + + ++ + + V E Q S L Q
Sbjct: 629 EVNEKAKKLVEME-REHEK--SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKS 685
Query: 692 GKLEAQIESLSRENECLRKTNES---DSDALR--------------IKCKIIDDQTETIR 734
G+L +I L+ +N+ L+K E D+ L+ + K+ +D ++
Sbjct: 686 GELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHD 745
Query: 735 KLKDCLQEKDEHI-KRLQEKITEIEKCTQE--QLDEKSSQLDEVLEKLERHNERKEKLKQ 791
+ D L K + ++ EK E+EK E L + S+L+ V E+H + LK
Sbjct: 746 AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKS 805
Query: 792 QLKGKEVELEEIRKAYSTLNRKWH----------------------------DKGELLCH 823
+ + +L E++K K H + L
Sbjct: 806 NIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 865
Query: 824 LETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIA 883
++ +VK+KFE+ ++ +DK+ L++N L + + K + ++ E H+A+++
Sbjct: 866 TNRELLDVKKKFEDINQEFVKIKDKNEILKRN----LENTQNQIKAEYISLAE-HEAKMS 920
Query: 884 QLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 937
L+ +K DS + K E++ T+ A+IK L+ IQ+
Sbjct: 921 SLSQSMRKVQDSNAEILANYRKGQEEIV--------TLHAEIKAQKKELDTIQE 966
Score = 53.5 bits (127), Expect = 9e-07
Identities = 101/517 (19%), Positives = 212/517 (41%), Gaps = 48/517 (9%)
Query: 312 KPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDI 371
K E++ V + + N Q V+ D+ + E +N++ L +H + +
Sbjct: 865 KTNRELLDVKKKFEDIN--QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSL 922
Query: 372 HSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTV--ELMKAKDQQ----EDHL 425
D EI+ R + ++ + +++ + K+L E +K K E+
Sbjct: 923 SQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECE 982
Query: 426 KHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER---EQAQ 482
+ + EK L+ ++ Q+ + +++ + + +EI+ L+ L + E++
Sbjct: 983 RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1042
Query: 483 QLHQLLALKEQEHRKELE--TREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLS 540
++ + L+ K E K+L+ ++++ + ++ L +E AK+ E ++L
Sbjct: 1043 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS-------EILAVQNLLQ 1095
Query: 541 QQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLT 600
+Q++ LE VEA + + + EN+ EL + KE ++ + + L
Sbjct: 1096 KQHVPLEQ-------VEALK-KSLNGTIENLKEELKSMQRCY----EKEQQTVTKLHQLL 1143
Query: 601 CMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELA 660
K LAE ++K+ + +L E+ + K ++ L+ E L
Sbjct: 1144 ENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALK 1203
Query: 661 AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALR 720
E+ ++ K +L Q SSL + L + E + E +K S D
Sbjct: 1204 KLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKE 1263
Query: 721 IKCKIID----DQTE-------TIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKS 769
+ I+ DQ E TI +L+ +QE + I+ KITE+ E+L +
Sbjct: 1264 LLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN-DVERLKQAL 1322
Query: 770 SQLDEVL----EKLERHNERKEKLKQQLKGKEVELEE 802
+ L ++ +R ++ + L+ Q+K E +L +
Sbjct: 1323 NGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLAD 1359
Score = 45.4 bits (106), Expect = 2e-04
Identities = 75/382 (19%), Positives = 166/382 (43%), Gaps = 33/382 (8%)
Query: 191 KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEK--DPRPKRDTDITSESDYGNRK 248
+ +HE + K +L+ Q L+ L++ + NV EK + K+ ++I + + ++
Sbjct: 1039 EKSHEMERALSRKTDELNKQ-LKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQ 1097
Query: 249 ECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLK--ELYVSSSLANCPM 306
VP TI++ + S C K + K +L + ++ P+
Sbjct: 1098 H----VPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1153
Query: 307 -----LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDY-IDE 360
++E+ + + IIK E+ + Q+ +E++ + + + +QA KL + +
Sbjct: 1154 AEHLQIKEAFEKEVGIIKASLREKEEES-QNKMEEVSKLQSEVQNTKQALKKLETREVVD 1212
Query: 361 LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 420
L K+ K D+ + ++L + R + E ++H + EI AKD+
Sbjct: 1213 LSKYKATKSDLETQISSLNEKLANL---NRKYEEVCEEVLHAKKKEIS--------AKDE 1261
Query: 421 QEDHLKHLRTLEKTLEKMER-QKRQQQAAQI-RLIQEVELKASAADREIYLLRTSLHRER 478
+E L H ++ ++ ER K ++ R IQE + A D +I L + R +
Sbjct: 1262 KE--LLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLK 1319
Query: 479 EQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDV 538
+ L QL +++ + + T +L +++A +++H+++I Y+ +
Sbjct: 1320 QALNGLSQLTYTSGNPTKRQSQLID--TLQHQVKSLEQQLADADRQHQEVIAIYRTHLLS 1377
Query: 539 LSQQYMDLENEFRIALTVEARR 560
+Q +MD + + + ++ R+
Sbjct: 1378 AAQGHMDEDVQEALLQIIQMRQ 1399
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 100 bits (249), Expect = 6e-21
Identities = 167/839 (19%), Positives = 337/839 (40%), Gaps = 114/839 (13%)
Query: 177 LTSFMSVCQSSEPEKNNHENDLQNEIKLQKL------------DDQILQLLNETSNSIDN 224
L + + C+S++ ++ +N+L +++ K D+QI QL + +
Sbjct: 446 LEAMRTFCESAKQDRLKLQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKR 505
Query: 225 VLEKDPRPKR--------DTDITSESDYGNRK--ECNRKVPRRSKIPYDAKTIQTIKHHN 274
+ E + + K+ +TSE+ GN + E + + K+ Y+ + + K N
Sbjct: 506 MYESEGKVKQMQTHFLALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRN 565
Query: 275 --KNYNSFVSCNRKMKPPYLKE-LYVSSSLANCPMLQESEKPKTEIIKVDQSHSE----- 326
K V ++ + ++E + L+ C M E EK ++ +++ E
Sbjct: 566 QIKQNEMIVEEFKRDEGKLIEENKRLQKELSMCEM--EREKKGRKVTEMEGQAKELSAKL 623
Query: 327 ---------DNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLAL- 376
+N SL +++++ +K E+ K + I +L + E E++ +
Sbjct: 624 ALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLSEIRQLKR---ELENVKAKLAQ 680
Query: 377 -LTTDRLKEIIFRERNSKGQLEVMVHKL-------QNEIKKLTVELMKAKDQQEDHLKHL 428
+ + +++ R G+L + +L Q EI+K+ ++ K+Q + +
Sbjct: 681 HVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEM 740
Query: 429 RTLEKTLEKMERQKRQQQAA---QIRLIQEVELKASAADREIYLLRTSLHREREQAQQLH 485
+ L+ E K+ A R + +V K + E+ L + +L
Sbjct: 741 KNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLE 800
Query: 486 QLLALKEQEHRKELETREFFTDADFQ-DALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYM 544
+ E+ ++ + + + Q L K+ ++++K + E ++S QY+
Sbjct: 801 TVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYV 860
Query: 545 DLENEFRIALTVEA------RRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKD 598
++ + +T+ R DVK FE++ E K K +R + + IK
Sbjct: 861 PVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDINQEFVKIKDKNEILKRNLENTQNQIKA 920
Query: 599 LTCMVKEQKTKLAEVSKLKQ-------ETAANL---QNQINTLEILIEDDKQKSIQI-EL 647
+ E + K++ +S+ + E AN Q +I TL I+ K++ I E
Sbjct: 921 EYISLAEHEAKMSSLSQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQEC 980
Query: 648 LKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENEC 707
+K + ++S + K EL Q S Q E +++ +EN+
Sbjct: 981 IKVKYAPIVSFEECERKF--------KATEKELKDQLSEQTQKYSVSEEEVKKNKQENDK 1032
Query: 708 LRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDE 767
L+K + LR K +I+ E R L E ++ +K L +K TE++ ++ ++E
Sbjct: 1033 LKKEIFTLQKDLRDKTVLIEKSHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEE 1092
Query: 768 KSSQLDEVL----------------EKLERH-NERKEKLKQQLKGK----EVELEEIRKA 806
+ Q E+L E L++ N E LK++LK E E + + K
Sbjct: 1093 NAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKL 1152
Query: 807 YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 866
+ L + + L HL ++KE FE + +KA + E +N ME++ +
Sbjct: 1153 HQLLENQKNSSVPLAEHL-----QIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSE 1207
Query: 867 FKRQVDAIVEAHQAEIAQLANEK------QKCIDSANLKVHQIEKEMRELLEETCKNKK 919
+ A+ + E+ L+ K + I S N K+ + ++ E+ EE KK
Sbjct: 1208 VQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKK 1266
Score = 70.9 bits (172), Expect = 5e-12
Identities = 137/714 (19%), Positives = 287/714 (40%), Gaps = 112/714 (15%)
Query: 318 IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALL 377
+ V E Q L + + +E+ + +Q + L+D ++ L NE+ +
Sbjct: 284 VNVKSHQREHQNIQDLEIENEDLKERLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLES 343
Query: 378 TTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEK 437
++LK ++ + + + L+N K + + + + + + + +
Sbjct: 344 EREKLKSLLAAKEKQHEESLRTIEALKNRFKYFESDHLGSGSHFSNRKEDMLLKQGQMYM 403
Query: 438 MERQ-------KRQQQAAQIRLIQEVELKASAA-------DREIYLLRTSLHREREQAQQ 483
+ Q Q + +R + E+ L + + +E+ +RT ++ +
Sbjct: 404 ADSQCTSPGIPAHMQSRSMLRPL-ELSLPSQTSYSENEILKKELEAMRTFCESAKQDRLK 462
Query: 484 LHQLLALKEQEHRK-ELETREFFTDAD-----FQDALAKEIAKEEKKHEQMIKEYQEKID 537
L LA K E + LE D+D +DAL K++ K + E +K+ Q
Sbjct: 463 LQNELAHKVAECKALALECERVKEDSDEQIKQLEDAL-KDVQKRMYESEGKVKQMQTHFL 521
Query: 538 VLSQQYMDLENEFRIALTVEAR-RFQDVKDGFENVATELAK-----SKHALIWAQRKEN- 590
L + LT E + + +D+K +E + E+ K ++ +I + K +
Sbjct: 522 ALKEHLTSEAASGNHRLTEELKDQLKDLKVKYEGASAEVGKLRNQIKQNEMIVEEFKRDE 581
Query: 591 -----ESSSLIKDLTCMVKEQKTKLAEVSKLKQET------------AANLQNQINTLEI 633
E+ L K+L+ E++ K +V++++ + A +N ++L
Sbjct: 582 GKLIEENKRLQKELSMCEMEREKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSN 641
Query: 634 LIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTE--RKVWGHELAQQGSSLAQNR 691
+ + +K +++E +HEK +SE+ + + ++ + + V E Q S L Q
Sbjct: 642 EVNEKAKKLVEME-REHEK--SLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKS 698
Query: 692 GKLEAQIESLSRENECLRKTNES---DSDALR--------------IKCKIIDDQTETIR 734
G+L +I L+ +N+ L+K E D+ L+ + K+ +D ++
Sbjct: 699 GELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHD 758
Query: 735 KLKDCLQEKDEHI-KRLQEKITEIEKCTQE--QLDEKSSQLDEVLEKLERHNERKEKLKQ 791
+ D L K + ++ EK E+EK E L + S+L+ V E+H + LK
Sbjct: 759 AIIDDLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKS 818
Query: 792 QLKGKEVELEEIRKAYSTLNRKWH----------------------------DKGELLCH 823
+ + +L E++K K H + L
Sbjct: 819 NIVELKKQLSELKKKCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAK 878
Query: 824 LETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIA 883
++ +VK+KFE+ ++ +DK+ L++N L + + K + ++ E H+A+++
Sbjct: 879 TNRELLDVKKKFEDINQEFVKIKDKNEILKRN----LENTQNQIKAEYISLAE-HEAKMS 933
Query: 884 QLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 937
L+ +K DS + K E++ T+ A+IK L+ IQ+
Sbjct: 934 SLSQSMRKVQDSNAEILANYRKGQEEIV--------TLHAEIKAQKKELDTIQE 979
Score = 53.5 bits (127), Expect = 9e-07
Identities = 101/517 (19%), Positives = 212/517 (41%), Gaps = 48/517 (9%)
Query: 312 KPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDI 371
K E++ V + + N Q V+ D+ + E +N++ L +H + +
Sbjct: 878 KTNRELLDVKKKFEDIN--QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSL 935
Query: 372 HSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTV--ELMKAKDQQ----EDHL 425
D EI+ R + ++ + +++ + K+L E +K K E+
Sbjct: 936 SQSMRKVQDSNAEILANYRKGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECE 995
Query: 426 KHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER---EQAQ 482
+ + EK L+ ++ Q+ + +++ + + +EI+ L+ L + E++
Sbjct: 996 RKFKATEKELKDQLSEQTQKYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH 1055
Query: 483 QLHQLLALKEQEHRKELE--TREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLS 540
++ + L+ K E K+L+ ++++ + ++ L +E AK+ E ++L
Sbjct: 1056 EMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTS-------EILAVQNLLQ 1108
Query: 541 QQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLT 600
+Q++ LE VEA + + + EN+ EL + KE ++ + + L
Sbjct: 1109 KQHVPLEQ-------VEALK-KSLNGTIENLKEELKSMQRCY----EKEQQTVTKLHQLL 1156
Query: 601 CMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELA 660
K LAE ++K+ + +L E+ + K ++ L+ E L
Sbjct: 1157 ENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALK 1216
Query: 661 AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALR 720
E+ ++ K +L Q SSL + L + E + E +K S D
Sbjct: 1217 KLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKEISAKDEKE 1276
Query: 721 IKCKIID----DQTE-------TIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKS 769
+ I+ DQ E TI +L+ +QE + I+ KITE+ E+L +
Sbjct: 1277 LLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLN-DVERLKQAL 1335
Query: 770 SQLDEVL----EKLERHNERKEKLKQQLKGKEVELEE 802
+ L ++ +R ++ + L+ Q+K E +L +
Sbjct: 1336 NGLSQLTYTSGNPTKRQSQLIDTLQHQVKSLEQQLAD 1372
Score = 45.4 bits (106), Expect = 2e-04
Identities = 75/382 (19%), Positives = 166/382 (43%), Gaps = 33/382 (8%)
Query: 191 KNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEK--DPRPKRDTDITSESDYGNRK 248
+ +HE + K +L+ Q L+ L++ + NV EK + K+ ++I + + ++
Sbjct: 1052 EKSHEMERALSRKTDELNKQ-LKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQ 1110
Query: 249 ECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLK--ELYVSSSLANCPM 306
VP TI++ + S C K + K +L + ++ P+
Sbjct: 1111 H----VPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQKNSSVPL 1166
Query: 307 -----LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDY-IDE 360
++E+ + + IIK E+ + Q+ +E++ + + + +QA KL + +
Sbjct: 1167 AEHLQIKEAFEKEVGIIKASLREKEEES-QNKMEEVSKLQSEVQNTKQALKKLETREVVD 1225
Query: 361 LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQ 420
L K+ K D+ + ++L + R + E ++H + EI AKD+
Sbjct: 1226 LSKYKATKSDLETQISSLNEKLANL---NRKYEEVCEEVLHAKKKEIS--------AKDE 1274
Query: 421 QEDHLKHLRTLEKTLEKMER-QKRQQQAAQI-RLIQEVELKASAADREIYLLRTSLHRER 478
+E L H ++ ++ ER K ++ R IQE + A D +I L + R +
Sbjct: 1275 KE--LLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLNDVERLK 1332
Query: 479 EQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDV 538
+ L QL +++ + + T +L +++A +++H+++I Y+ +
Sbjct: 1333 QALNGLSQLTYTSGNPTKRQSQLID--TLQHQVKSLEQQLADADRQHQEVIAIYRTHLLS 1390
Query: 539 LSQQYMDLENEFRIALTVEARR 560
+Q +MD + + + ++ R+
Sbjct: 1391 AAQGHMDEDVQEALLQIIQMRQ 1412
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 100 bits (249), Expect = 6e-21
Identities = 160/813 (19%), Positives = 332/813 (40%), Gaps = 125/813 (15%)
Query: 199 QNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRS 258
++E K ++L+++++ LL E N + ++ + D + + C++ + +
Sbjct: 871 KSEAKRKELEEKMVTLLKE-KNDLQLQVQAEAEGLADAE----------ERCDQLIKTKI 919
Query: 259 KIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEII 318
++ K + + N+ ++ ++ EL ++ + + +
Sbjct: 920 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK-----------KDIDDLELTLA 968
Query: 319 KVD-QSHSEDNTYQSLVEQ---LDQEREKRWRAEQA-ENKLMDYIDELHKHANEKEDIHS 373
KV+ + H+ +N ++L E+ LD+ K + ++A + +D+L ++ +
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028
Query: 374 LALLT---TDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRT 430
+ D L+ + +E+ + LE KL+ ++K +M +++++ + L+
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088
Query: 431 LEKTLEKMERQKRQQQAAQIRL---IQEVELKASAADREIYLLRTSLHREREQAQQLHQL 487
E + ++ + +QA I+L I+E++ + + EI R S + +Q L +
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1148
Query: 488 L---------------ALKEQEHRKELETREFFTDADFQDALAKEI--AKEEKKHEQMIK 530
L A E ++E E ++ D + + L E A KKH +
Sbjct: 1149 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE-EATLQHEATAATLRKKHADSVA 1207
Query: 531 EYQEKIDVLSQQYMDLE---NEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQR 587
E E+ID L + LE +E ++ + A + V N+ + L +
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 588 KENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIEL 647
KE E LI DLT +T+ E S+ E A + L + + QIE
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ-------LSRGKQAFTQQIEE 1320
Query: 648 LKHEKVQLISELAAKESLIFGLRTERKVWGHE---LAQQGSSLAQNRGKLEAQIESLSRE 704
LK QL E+ AK +L L++ R H+ L +Q +++ +L+ + + E
Sbjct: 1321 LKR---QLEEEIKAKNALAHALQSSR----HDCDLLREQYEEEQESKAELQRALSKANTE 1373
Query: 705 NECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQE- 763
R E+D+ + ++ E +KL LQ +EH++ + K +EK Q
Sbjct: 1374 VAQWRTKYETDA------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL 1427
Query: 764 -------------------QLDEKSSQLDEVL----EKLERHNERKEKLKQQLKGKEVEL 800
LD+K D++L +K E + E +++ + EL
Sbjct: 1428 QNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL 1487
Query: 801 EEIRKAYS-------TLNRKWHDKGELLCHLETQVKE----------VKEKFENKEKKLK 843
+I+ AY TL R+ + + + L Q+ E +K++ E ++ +L+
Sbjct: 1488 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ 1547
Query: 844 A---ERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 900
A E + S+E ++ + ++ + K +VD + EI QL + ++S
Sbjct: 1548 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ--- 1604
Query: 901 HQIEKEMRELLEETCKNKKTMEAKIKQLAFALN 933
++ E+R + + KK ME + ++ LN
Sbjct: 1605 STLDAEIRS-RNDAIRLKKKMEGDLNEMEIQLN 1636
Score = 92.4 bits (228), Expect = 2e-18
Identities = 122/553 (22%), Positives = 252/553 (45%), Gaps = 47/553 (8%)
Query: 404 QNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA 463
+ E+ + E K KD+ + LE EKM +++ Q+++ E E A A
Sbjct: 852 EKEMATMKEEFQKIKDELAKSEAKRKELE---EKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 464 DREIYLLRTSLHRER------EQAQQLHQLLA-LKEQEHRKELETREFFTDADFQDALAK 516
+R L++T + E E+A+ ++ A L ++ + E E E D D +
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 517 EIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELA 576
++ KE+ E +K E++ L + L E + + D++ + V T L
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT-LT 1027
Query: 577 KSKHALIWAQRKENESSSLI--KDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEIL 634
K+K L Q+ ++ SL K L ++ K KL KL QE+ +++N+ L+
Sbjct: 1028 KAKIKL--EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD-- 1083
Query: 635 IEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWG-----HELAQQGSSLAQ 689
E K+K +I L+ S++ +++L G++ ++K+ EL ++ +
Sbjct: 1084 -EKLKKKEFEISNLQ-------SKIEDEQAL--GIQLQKKIKELQARIEELEEEIEAERA 1133
Query: 690 NRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKR 749
+R K E Q LSRE E + + E A + ++ + +K++ L+E
Sbjct: 1134 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT----- 1188
Query: 750 LQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYST 809
LQ + T +++ + ++L E ++ L+R ++ EK K ++K +E++++ T
Sbjct: 1189 LQHEATAAT--LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK---MEIDDLASNVET 1243
Query: 810 LNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMD--DAF 867
+++ + ++ LE Q+ E+K K E +++ + + LQ + E +D +A
Sbjct: 1244 VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEAL 1303
Query: 868 KRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMR--ELLEETCKNKKTMEAKI 925
Q+ +A +I +L + ++ I + N H ++ +LL E + ++ +A++
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 926 KQ-LAFALNEIQQ 937
++ L+ A E+ Q
Sbjct: 1364 QRALSKANTEVAQ 1376
Score = 70.9 bits (172), Expect = 5e-12
Identities = 134/633 (21%), Positives = 262/633 (41%), Gaps = 111/633 (17%)
Query: 296 YVSSSLANCPMLQESEKPKTEIIKVDQSHSE---------DNTYQSL---VEQLDQEREK 343
Y + ++ L+E++K + ++ + H E + T Q L VE L + E+
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 344 RWRAEQAENKLMDYIDELHKHANEK-EDIHSLALLTTDRLKEI---IFRERNSKGQLEVM 399
A A +K D++ +K E+ H+ + + + +F+ +N+ +
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 400 VHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELK 459
+ L+ E K L E+ +Q + K + LEK +++E++K + QAA ++E E
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA----LEEAE-- 1554
Query: 460 ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIA 519
AS E +LR L +L +K + RK
Sbjct: 1555 ASLEHEEGKILRIQL-----------ELNQVKSEVDRK---------------------- 1581
Query: 520 KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK 579
I E E+ID L + ++ + + L E R D + + +L + +
Sbjct: 1582 ---------IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 580 HALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQ---ETAANLQNQINTLEILIE 636
L A R E+ ++ ++K+ + L + + ++ E A ++ + N L+ IE
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIE 1692
Query: 637 DDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEA 696
+ + Q E + Q + + + + L L Q +SL + KLE
Sbjct: 1693 ELRATLEQTERSRKIAEQELLDASERVQL--------------LHTQNTSLINTKKKLET 1738
Query: 697 QIESLSRENE-CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKIT 755
I + E E L++ ++ A K I D +LK Q+ H++R+++ +
Sbjct: 1739 DISQMQGEMEDILQEARNAEEKAK----KAITDAAMMAEELKK-EQDTSAHLERMKKNME 1793
Query: 756 EIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWH 815
+ K Q +LDE + QL L+ ++ ++ E ++L+G EVE E+ R A + + H
Sbjct: 1794 QTVKDLQLRLDE-AEQL--ALKGGKKQIQKLEARVRELEG-EVESEQKRNAEAVKGLRKH 1849
Query: 816 DKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIV 875
E +VKE+ + E K + + LQ + ++KL + ++KRQ +
Sbjct: 1850 ---------ERRVKELTYQTEEDRKNI-------LRLQ-DLVDKLQAKVKSYKRQAEEAE 1892
Query: 876 EAHQAEIA---QLANEKQKCIDSANLKVHQIEK 905
E +A +L +E ++ + A++ Q+ K
Sbjct: 1893 EQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 100 bits (249), Expect = 6e-21
Identities = 160/813 (19%), Positives = 332/813 (40%), Gaps = 125/813 (15%)
Query: 199 QNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKVPRRS 258
++E K ++L+++++ LL E N + ++ + D + + C++ + +
Sbjct: 871 KSEAKRKELEEKMVTLLKE-KNDLQLQVQAEAEGLADAE----------ERCDQLIKTKI 919
Query: 259 KIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEII 318
++ K + + N+ ++ ++ EL ++ + + +
Sbjct: 920 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK-----------KDIDDLELTLA 968
Query: 319 KVD-QSHSEDNTYQSLVEQ---LDQEREKRWRAEQA-ENKLMDYIDELHKHANEKEDIHS 373
KV+ + H+ +N ++L E+ LD+ K + ++A + +D+L ++ +
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028
Query: 374 LALLT---TDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRT 430
+ D L+ + +E+ + LE KL+ ++K +M +++++ + L+
Sbjct: 1029 AKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKK 1088
Query: 431 LEKTLEKMERQKRQQQAAQIRL---IQEVELKASAADREIYLLRTSLHREREQAQQLHQL 487
E + ++ + +QA I+L I+E++ + + EI R S + +Q L +
Sbjct: 1089 KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRE 1148
Query: 488 L---------------ALKEQEHRKELETREFFTDADFQDALAKEI--AKEEKKHEQMIK 530
L A E ++E E ++ D + + L E A KKH +
Sbjct: 1149 LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE-EATLQHEATAATLRKKHADSVA 1207
Query: 531 EYQEKIDVLSQQYMDLE---NEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQR 587
E E+ID L + LE +E ++ + A + V N+ + L +
Sbjct: 1208 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 588 KENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIEL 647
KE E LI DLT +T+ E S+ E A + L + + QIE
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ-------LSRGKQAFTQQIEE 1320
Query: 648 LKHEKVQLISELAAKESLIFGLRTERKVWGHE---LAQQGSSLAQNRGKLEAQIESLSRE 704
LK QL E+ AK +L L++ R H+ L +Q +++ +L+ + + E
Sbjct: 1321 LKR---QLEEEIKAKNALAHALQSSR----HDCDLLREQYEEEQESKAELQRALSKANTE 1373
Query: 705 NECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQE- 763
R E+D+ + ++ E +KL LQ +EH++ + K +EK Q
Sbjct: 1374 VAQWRTKYETDA------IQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRL 1427
Query: 764 -------------------QLDEKSSQLDEVL----EKLERHNERKEKLKQQLKGKEVEL 800
LD+K D++L +K E + E +++ + EL
Sbjct: 1428 QNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL 1487
Query: 801 EEIRKAYS-------TLNRKWHDKGELLCHLETQVKE----------VKEKFENKEKKLK 843
+I+ AY TL R+ + + + L Q+ E +K++ E ++ +L+
Sbjct: 1488 FKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQ 1547
Query: 844 A---ERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 900
A E + S+E ++ + ++ + K +VD + EI QL + ++S
Sbjct: 1548 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ--- 1604
Query: 901 HQIEKEMRELLEETCKNKKTMEAKIKQLAFALN 933
++ E+R + + KK ME + ++ LN
Sbjct: 1605 STLDAEIRS-RNDAIRLKKKMEGDLNEMEIQLN 1636
Score = 92.4 bits (228), Expect = 2e-18
Identities = 122/553 (22%), Positives = 252/553 (45%), Gaps = 47/553 (8%)
Query: 404 QNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAA 463
+ E+ + E K KD+ + LE EKM +++ Q+++ E E A A
Sbjct: 852 EKEMATMKEEFQKIKDELAKSEAKRKELE---EKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 464 DREIYLLRTSLHRER------EQAQQLHQLLA-LKEQEHRKELETREFFTDADFQDALAK 516
+R L++T + E E+A+ ++ A L ++ + E E E D D +
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 517 EIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELA 576
++ KE+ E +K E++ L + L E + + D++ + V T L
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT-LT 1027
Query: 577 KSKHALIWAQRKENESSSLI--KDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEIL 634
K+K L Q+ ++ SL K L ++ K KL KL QE+ +++N+ L+
Sbjct: 1028 KAKIKL--EQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLD-- 1083
Query: 635 IEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWG-----HELAQQGSSLAQ 689
E K+K +I L+ S++ +++L G++ ++K+ EL ++ +
Sbjct: 1084 -EKLKKKEFEISNLQ-------SKIEDEQAL--GIQLQKKIKELQARIEELEEEIEAERA 1133
Query: 690 NRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKR 749
+R K E Q LSRE E + + E A + ++ + +K++ L+E
Sbjct: 1134 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT----- 1188
Query: 750 LQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYST 809
LQ + T +++ + ++L E ++ L+R ++ EK K ++K +E++++ T
Sbjct: 1189 LQHEATAAT--LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK---MEIDDLASNVET 1243
Query: 810 LNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMD--DAF 867
+++ + ++ LE Q+ E+K K E +++ + + LQ + E +D +A
Sbjct: 1244 VSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEAL 1303
Query: 868 KRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMR--ELLEETCKNKKTMEAKI 925
Q+ +A +I +L + ++ I + N H ++ +LL E + ++ +A++
Sbjct: 1304 VSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAEL 1363
Query: 926 KQ-LAFALNEIQQ 937
++ L+ A E+ Q
Sbjct: 1364 QRALSKANTEVAQ 1376
Score = 70.9 bits (172), Expect = 5e-12
Identities = 134/633 (21%), Positives = 262/633 (41%), Gaps = 111/633 (17%)
Query: 296 YVSSSLANCPMLQESEKPKTEIIKVDQSHSE---------DNTYQSL---VEQLDQEREK 343
Y + ++ L+E++K + ++ + H E + T Q L VE L + E+
Sbjct: 1381 YETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVER 1440
Query: 344 RWRAEQAENKLMDYIDELHKHANEK-EDIHSLALLTTDRLKEI---IFRERNSKGQLEVM 399
A A +K D++ +K E+ H+ + + + +F+ +N+ +
Sbjct: 1441 TNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQ 1500
Query: 400 VHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELK 459
+ L+ E K L E+ +Q + K + LEK +++E++K + QAA ++E E
Sbjct: 1501 LETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAA----LEEAE-- 1554
Query: 460 ASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIA 519
AS E +LR L +L +K + RK
Sbjct: 1555 ASLEHEEGKILRIQL-----------ELNQVKSEVDRK---------------------- 1581
Query: 520 KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK 579
I E E+ID L + ++ + + L E R D + + +L + +
Sbjct: 1582 ---------IAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEME 1632
Query: 580 HALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQ---ETAANLQNQINTLEILIE 636
L A R E+ ++ ++K+ + L + + ++ E A ++ + N L+ IE
Sbjct: 1633 IQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIE 1692
Query: 637 DDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEA 696
+ + Q E + Q + + + + L L Q +SL + KLE
Sbjct: 1693 ELRATLEQTERSRKIAEQELLDASERVQL--------------LHTQNTSLINTKKKLET 1738
Query: 697 QIESLSRENE-CLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKIT 755
I + E E L++ ++ A K I D +LK Q+ H++R+++ +
Sbjct: 1739 DISQMQGEMEDILQEARNAEEKAK----KAITDAAMMAEELKK-EQDTSAHLERMKKNME 1793
Query: 756 EIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWH 815
+ K Q +LDE + QL L+ ++ ++ E ++L+G EVE E+ R A + + H
Sbjct: 1794 QTVKDLQLRLDE-AEQL--ALKGGKKQIQKLEARVRELEG-EVESEQKRNAEAVKGLRKH 1849
Query: 816 DKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIV 875
E +VKE+ + E K + + LQ + ++KL + ++KRQ +
Sbjct: 1850 ---------ERRVKELTYQTEEDRKNI-------LRLQ-DLVDKLQAKVKSYKRQAEEAE 1892
Query: 876 EAHQAEIA---QLANEKQKCIDSANLKVHQIEK 905
E +A +L +E ++ + A++ Q+ K
Sbjct: 1893 EQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 100 bits (248), Expect = 8e-21
Identities = 119/546 (21%), Positives = 248/546 (45%), Gaps = 88/546 (16%)
Query: 340 EREKRWRAEQAENKLMD-YIDELHKHANEKEDIHSLAL----LTTDRLKEIIFRERNSKG 394
E E+ A + K D YI+EL K + D SL L +T + LKE + +
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTK----ERDALSLELYRNTITDEELKEKNAKLQEKLQ 231
Query: 395 QLEVMVHKLQNEIKKLTVELMKAK--------DQQEDHL-KHLRTLEKTLE--------- 436
+E ++Q +K+L +L +AK + DHL K L+++ L+
Sbjct: 232 LVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELW 291
Query: 437 -KMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEH 495
++ +Q+ ++ Q IQE E K + +I + + E+ ++ +++ KE++
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 496 RKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALT 555
R+ Q+ + E ++ ++ E+M+ E +EKI L ++ + E
Sbjct: 352 RR-------------QEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQE-------- 390
Query: 556 VEARRFQDVKDGFENVAT-ELAKSKHALIWAQRKE-NESSSLIKDLTCMVKEQKTKLAEV 613
+ R ++ + E + E + + A +W Q ++ E I++ + Q+ K+ E
Sbjct: 391 -KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 449
Query: 614 SKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTER 673
K+++E Q ++ E I + ++ Q E + HE+ ++ + E
Sbjct: 450 EKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKM-HEQEKIRKQ-------------EE 495
Query: 674 KVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETI 733
KVW +Q + K+ Q E + R+ E +R+ E I +Q E I
Sbjct: 496 KVW-----RQEEKMHDQEEKIREQEEKMWRQEEKIREQEEK-----------IREQEEKI 539
Query: 734 RKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQL 793
R+ ++ +QE++E + +EK+ E EK +++ ++ Q +++ E+ E+ E++EK+ +Q
Sbjct: 540 REQEEMMQEQEEKMGEQEEKMQEQEKMRRQE-EKIREQEEKIREQKEKIREQEEKIWEQ- 597
Query: 794 KGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQ 853
E ++ E + K ++ E +C E +++E +EK +E+K+ E++ + Q
Sbjct: 598 ---EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM-WEQEVRLRQQ 653
Query: 854 KNAMEK 859
+ M++
Sbjct: 654 EEKMQE 659
Score = 86.3 bits (212), Expect = 1e-16
Identities = 125/580 (21%), Positives = 256/580 (44%), Gaps = 94/580 (16%)
Query: 362 HKHANEKE---DIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAK 418
H+ A +E +H++ +LT K +L++ ++ Q+ +K+L E
Sbjct: 117 HQEALRRELEAQVHTIRILTCQ------------KTELQMALYYSQHAVKQLEGEARDLI 164
Query: 419 DQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHRER 478
+ D K LE+ L + QK++ R I+E+ + A E+Y + +
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKKKAD----RYIEELTKERDALSLELYRNTITDEELK 220
Query: 479 EQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDV 538
E+ +L + L L E E + E++ KE+ ++ ++ + ++ + Q
Sbjct: 221 EKNAKLQEKLQLVESE-KSEIQLN------------VKELKRKLERAKLLLPQQQ----- 262
Query: 539 LSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKD 598
L + L E + +V A+ V++ + L + + +W Q ++ I++
Sbjct: 263 LQAEADHLGKELQ---SVSAKLQAQVEEN--ELWNRLNQQQEEKMWRQEEK------IQE 311
Query: 599 LTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELL--KHEKVQLI 656
++EQ+ K+ E + +E ++ Q E++ E +++ Q E++ K EK++ +
Sbjct: 312 WEEKIQEQEEKIREQEEKIREQEEKMRRQE---EMMWEKEEKMRRQEEMMWEKEEKMRRL 368
Query: 657 SELA-AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESD 715
E+ KE I L E K+ E ++ Q K+ Q + +E + R
Sbjct: 369 EEMMWEKEEKIREL--EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWR------ 420
Query: 716 SDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEV 775
Q E IR+ ++ ++E+++ + R +EKI E EK +E EK + +E+
Sbjct: 421 -------------QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE---EKRQEQEEM 464
Query: 776 LEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNR---KWHDKGELLCHLETQVKEVK 832
+ E+ E++E +Q K K E E+IRK + R K HD+ E + E ++ +
Sbjct: 465 WRQEEKIREQEEIWRQ--KEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQE 522
Query: 833 EKFENKEKKLKAERDKSIELQKNAMEKLHSM---------DDAFKRQVDAIVEAHQ--AE 881
EK +E+K++ + +K E ++ E+ M + +RQ + I E + E
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIRE 582
Query: 882 IAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTM 921
+ E+++ I K+ + E+ M+E E+ + ++ M
Sbjct: 583 QKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM 622
Score = 82.4 bits (202), Expect = 2e-15
Identities = 77/341 (22%), Positives = 164/341 (48%), Gaps = 28/341 (8%)
Query: 603 VKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAK 662
+KE+ KL E +L + + +Q + L+ +E K Q + L+ E L EL +
Sbjct: 219 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQ-QQLQAEADHLGKELQSV 277
Query: 663 ESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNES---DSDAL 719
+ + E ++W QQ + + K++ E + + E +R+ E + +
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKM 337
Query: 720 RIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKL 779
R + +++ ++ E +R+ ++ + EK+E ++RL+E + E E+ +E L+EK + +++ E+
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRE-LEEKMHEQEKIREQE 396
Query: 780 ERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKE 839
E+ E +EK+++Q K +E E + R+ E +++E +EK +E
Sbjct: 397 EKRQE-EEKIREQEKRQEQEAKMWRQ-------------------EEKIREQEEKIREQE 436
Query: 840 KKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLK 899
KK+ + +K E +K E+ + RQ + I E + + +Q+ I K
Sbjct: 437 KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEK 496
Query: 900 VHQIEKEMRELLEETCKNKKTM---EAKIKQLAFALNEIQQ 937
V + E++M + E+ + ++ M E KI++ + E ++
Sbjct: 497 VWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEE 537
Score = 80.1 bits (196), Expect = 9e-15
Identities = 112/544 (20%), Positives = 240/544 (44%), Gaps = 79/544 (14%)
Query: 279 SFVSCNRKMKPPYLKELY-----VSSSLANCPMLQESEKPKTEII--KVDQSHSEDNTYQ 331
S V+ +K Y++EL +S L + E K K + K+ SE + Q
Sbjct: 182 SAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQ 241
Query: 332 SLVEQLDQEREK----------RWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR 381
V++L ++ E+ + A+ +L +L E E + L +
Sbjct: 242 LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL----NQQ 297
Query: 382 LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ 441
+E ++R+ + E K+Q + +K+ + K ++Q+E K R E EK E+
Sbjct: 298 QEEKMWRQEEKIQEWE---EKIQEQEEKIREQEEKIREQEE---KMRRQEEMMWEKEEKM 351
Query: 442 KRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELET 501
+RQ++ ++ E E K + ++ + RE +++H+ ++EQE +++ E
Sbjct: 352 RRQEE-----MMWEKEEKMRRLEEMMWEKEEKI---RELEEKMHEQEKIREQEEKRQEE- 402
Query: 502 REFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRF 561
++I ++EK+ EQ K ++++ + Q+ E E ++ E
Sbjct: 403 --------------EKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 448
Query: 562 QDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLK--QE 619
Q E + E + + +W Q ++ I QK K+ E K++ +E
Sbjct: 449 Q------EKIREEEKRQEQEEMWRQEEKIREQEEIW-------RQKEKMHEQEKIRKQEE 495
Query: 620 TAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHE 679
+ +++ E I + ++K + E E+ + I E K +R + ++
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEK------IREQEEM---- 545
Query: 680 LAQQGSSLAQNRGKLEAQIESLSRENECLRKTNES---DSDALRIKCKIIDDQTETIRKL 736
+ +Q + + K++ Q E + R+ E +R+ E + +R + + I +Q E IR+
Sbjct: 546 MQEQEEKMGEQEEKMQEQ-EKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQ 604
Query: 737 KDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGK 796
++ +QE++E + +EK+ E E+ QEQ ++ Q +++ E+ R +++EK+++ +
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Query: 797 EVEL 800
E +
Sbjct: 665 EAAI 668
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 100 bits (248), Expect = 8e-21
Identities = 127/615 (20%), Positives = 268/615 (43%), Gaps = 65/615 (10%)
Query: 307 LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQA-----------ENKLM 355
L+E EK E+ + ++ E + EQ+ ++ EK W E+ E +L
Sbjct: 323 LREQEK---ELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379
Query: 356 DYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELM 415
+ ++ + + D +RL+E R R + E V K++ E KK+ +
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE-QVEKMREE-KKMQEQEK 437
Query: 416 KAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLH 475
K +DQ+E + R E+ EK R++ + Q +Q+ E + + +
Sbjct: 438 KTRDQEEKMQEEERIRER--EKKMREEEETMREQEEKMQKQEENMWEQEEKEW----QQQ 491
Query: 476 REREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQ--MIKEYQ 533
R EQ ++L + ++EQE K E E D + K++ ++EK EQ + E +
Sbjct: 492 RLPEQKEKLWEQEKMQEQEE-KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQE 550
Query: 534 EKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESS 593
EK+ Q+ D E + ++ D + E + + + ++K E
Sbjct: 551 EKMRDQEQKMWDQEERMEKKTQEQEKKTWDQE--------EKMREEERMREREKKMREEE 602
Query: 594 SLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKV 653
++++ ++EQ+ K+ E + E +Q Q E + + ++K + E E+
Sbjct: 603 EMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ----EEKMWEQEEKMWEQEEKMWEQQ 658
Query: 654 QLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNE 713
+L + + K+W HE Q+ + + K+ Q + + E +KT
Sbjct: 659 RLPEQ-------------KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKT-- 703
Query: 714 SDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLD 773
D + +R + E++R+ + ++E++E ++ +EK+ E E+ QEQ +E Q +
Sbjct: 704 WDQEKMR--------EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
Query: 774 EVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKE 833
++ E+ E+ E++ +Q+ K E E + ++ K D+ E + E +++ +E
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEE 815
Query: 834 KFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCI 893
K +E+K+ + +K EK+ ++ Q + + E Q + ++ +++K +
Sbjct: 816 KMRGQEEKMWGQEEK----MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEK-M 870
Query: 894 DSANLKVHQIEKEMR 908
K+ + E++MR
Sbjct: 871 RGQEEKMREQEEKMR 885
Score = 98.2 bits (243), Expect = 3e-20
Identities = 163/798 (20%), Positives = 342/798 (42%), Gaps = 112/798 (14%)
Query: 185 QSSEPEKNNHEND--LQNEIKLQKLDDQILQLLNETSNSIDNVL---EKDPRPKRDTDIT 239
Q E +K +H++ L+ EI+ Q D +++L ++ L + R D ++
Sbjct: 78 QLKEEKKASHQHQEALRREIEAQ---DHTIRILTCQKTELETALYYSQDAARKFEDGNLG 134
Query: 240 SESDYGNR-KECNRKVP----RRSKIPYDAKTIQTIKHHNKNYN-------SFVSCNRKM 287
+ S + + R P S IP ++K + HH+ ++ S VS K
Sbjct: 135 TPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTRHKK 194
Query: 288 KPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRA 347
Y++EL +E + E+ + T + L ++ + +EK A
Sbjct: 195 ADRYIEEL-----------TKERDALSLELYR------NTITNEELKKKNAELQEKLPLA 237
Query: 348 EQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEI 407
E ++++ + EL + + + L + T+ L+E ++R+ + E + K + ++
Sbjct: 238 ESEKSEIQLNVKELKRKLERAKFL--LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM 295
Query: 408 ----KKLTVELMKAKDQQED---HLKHLRTLEKTLEKMERQKRQQQ--AAQIRLIQEVEL 458
++L + K ++Q+E K LR EK L + E++ R+Q+ Q +QE E
Sbjct: 296 WRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
Query: 459 KASAADREIYLLRTSLHRERE-----QAQQLHQLLALKEQEHR---KELETREFFTDADF 510
K + ++ + R+ E + Q Q +++QE R ++ RE
Sbjct: 356 KMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMRE 415
Query: 511 QDALAKEIAK--EEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVK--D 566
Q+ + +++ K EEKK ++ K+ +++ + + ++ E E ++ E R Q+ K
Sbjct: 416 QEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQK 475
Query: 567 GFENVATELAK--------SKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKL-K 617
EN+ + K + +W Q K E I + +++Q+ + K+ +
Sbjct: 476 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR 535
Query: 618 QETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWG 677
QE ++Q+ E + D +QK E +K Q E+K W
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQ---------------EQEKKTWD 580
Query: 678 HELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLK 737
E + + R K + E + RE E K E + + +Q E + + +
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQE--EKMQEQEEK--------MQEQEEKMWEQE 630
Query: 738 DCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKE 797
+ +QE++E + +EK+ E E+ EQ +L E EKL H + +E+ K Q + ++
Sbjct: 631 EKMQEQEEKMWEQEEKMWEQEEKMWEQ-----QRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 798 V-ELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNA 856
+ E E++ K +K D+ ++ E ++E ++K +E+ ++ + +K E +
Sbjct: 686 IWEQEKMEKKTQEQEKKTWDQEKM--REEESMREREKKMREEEEMMREQEEKMQEQE--- 740
Query: 857 MEKLHSMDDAFKRQVDAIVEAHQA--EIAQLANEKQKCIDSANL----KVHQIEKEMREL 910
EK+ ++ Q + + E + E +L +K+K + + K+ + E++MR+
Sbjct: 741 -EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ 799
Query: 911 LEETCKNKKTMEAKIKQL 928
E+ ++ M + +++
Sbjct: 800 EEKMRGQEEKMRGQEEKM 817
Score = 59.3 bits (142), Expect = 2e-08
Identities = 89/462 (19%), Positives = 200/462 (43%), Gaps = 39/462 (8%)
Query: 475 HREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQE 534
H + Q QL K+ H+ + R + + QD + + ++ + E + Q+
Sbjct: 67 HSPEDTQQNRAQLKEEKKASHQHQEALRR---EIEAQDHTIRILTCQKTELETALYYSQD 123
Query: 535 KIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSS 594
+ + F +AL+ + F+ G + + +SK + +
Sbjct: 124 AARKFEDGNLGTPSSFNLALS---QAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGE 180
Query: 595 LIKDLTCMVKEQKTKLAEVSKL-KQETAANLQNQINTLEILIEDDKQKSIQIE----LLK 649
L + L+ + K + +L K+ A +L+ NT I E+ K+K+ +++ L +
Sbjct: 181 LQRALSAVSTRHKKADRYIEELTKERDALSLELYRNT--ITNEELKKKNAELQEKLPLAE 238
Query: 650 HEKVQL---ISELAAK-ESLIFGL-RTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRE 704
EK ++ + EL K E F L + + E+ +Q L + K+ Q E + R+
Sbjct: 239 SEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQ 298
Query: 705 NECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQ 764
E LR+ + +Q E + + + L+E+++ ++ ++++ E Q++
Sbjct: 299 EERLREQEGK-----------MREQEEKMWRQEKRLREQEKELREQEKELRE-----QKE 342
Query: 765 LDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHL 824
L E+ Q+ E EK+ E+ + ++++ +E L E K +K D+ E +
Sbjct: 343 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 402
Query: 825 ETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQ 884
+ +++E +E+ +E K+ + +K E +K ++ + D K Q + + + ++
Sbjct: 403 DERLREKEERMREQE-KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM-- 459
Query: 885 LANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIK 926
E+++ + K+ + E+ M E E+ + ++ E K K
Sbjct: 460 --REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 499
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 98.6 bits (244), Expect = 2e-20
Identities = 155/708 (21%), Positives = 303/708 (42%), Gaps = 102/708 (14%)
Query: 307 LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHAN 366
L+E E+ ++++ +E Q+ E + E R R + +L + + +L
Sbjct: 875 LEEMERKHQQLLEEKNILAEQ--LQAETELFAEAEEMRARLAAKKQELEEILHDLESRVE 932
Query: 367 EKEDIHSLALLTTDR-------LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKD 419
E+E+ + + + L+E + E ++ +L++ + +IKK+ E++ +D
Sbjct: 933 EEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLED 992
Query: 420 QQEDHLKHLRTLEKTLEKM-----ERQKRQQQAAQIRLIQEVEL--------KASAADRE 466
Q +K + +E + + E +++ + A+IR QEV + K +E
Sbjct: 993 QNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE 1052
Query: 467 IYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHE 526
+ + L E Q L + E + +L +E + Q ALA+ +E H+
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKE----EELQGALAR--GDDETLHK 1106
Query: 527 ----QMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHAL 582
++++E Q +I L + D E+E E ++ +D+ + E + TEL +
Sbjct: 1107 NNALKVVRELQAQIAELQE---DFESEKASRNKAEKQK-RDLSEELEALKTELEDTLDTT 1162
Query: 583 IWAQ----RKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEI----- 633
Q ++E E + L K L +E K A++ ++Q A L+ LE
Sbjct: 1163 AAQQELRTKREQEVAELKKALE---EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK 1219
Query: 634 ---------LIEDDKQKSIQIELLKHEKVQL----------ISELAAKESLIFGLRTERK 674
L D+K+ + ++++L+ K + + EL AK S LR E
Sbjct: 1220 ANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVE-- 1277
Query: 675 VWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTET-- 732
LA++ S L + +E ++ K S L+ +++ ++T
Sbjct: 1278 -----LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL 1332
Query: 733 -----IRKL---KDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNE 784
IR+L K+ LQE+ E + ++ + + Q QL + ++D+ L +E E
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEE 1392
Query: 785 RKEKLKQQLKGKEVELEEIRKAY----STLNRKWHDKGELLCHLETQVKEVKEKFENKEK 840
K+KL + + LEE AY T NR + +L L+ Q ++V E K+K
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ-RQVASNLEKKQK 1451
Query: 841 K---LKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANE------KQK 891
K L AE +KSI + A E+ + +A +++ A+ A E A A E KQ
Sbjct: 1452 KFDQLLAE-EKSIS-ARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQL 1509
Query: 892 CIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 939
D +L + ++ + + E K+K+ +E +++++ L E++ ++
Sbjct: 1510 RADMEDLM--SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Score = 96.3 bits (238), Expect = 1e-19
Identities = 122/575 (21%), Positives = 251/575 (43%), Gaps = 104/575 (18%)
Query: 398 VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKR---QQQAAQIRLIQ 454
+ V + + E++ EL+K K++Q L +E+ +++ +K +Q A+ L
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFA 904
Query: 455 EVE---LKASAADREIYLLRTSLHREREQAQQLHQLLA---LKEQEHRKELETREFFTDA 508
E E + +A +E+ + L E+ ++ +Q+L K Q H ++LE +
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ-----L 959
Query: 509 DFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGF 568
D ++ +++ E+ E IK+ +E+I +L Q E ++ ++D
Sbjct: 960 DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL-----------MEDRI 1008
Query: 569 ENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQET---AANLQ 625
+++LA+ + + N+ +I DL +K+++ E+ K K++ +LQ
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 626 NQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIF----GLRTERKVWGH--E 679
+QI L+ I++ ++++L K E+ +L LA + L+ R++ E
Sbjct: 1069 DQIAELQAQIDE-----LKLQLAKKEE-ELQGALARGDDETLHKNNALKVVRELQAQIAE 1122
Query: 680 LAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDC 739
L + S +R K E Q LS E E L+ E D + ++ + + + +LK
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182
Query: 740 LQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVE 799
L+E+ ++ E Q+ ++ L+E+ E+LE+ K L++ +G E
Sbjct: 1183 LEEETKN----------HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLET- 1231
Query: 800 LEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEK 859
D EL C ++ +++VK + E+K KKL A+ +++
Sbjct: 1232 ----------------DNKELACEVKV-LQQVKAESEHKRKKLDAQ-----------VQE 1263
Query: 860 LHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEK-------------- 905
LH+ R + E+A+ A++ Q +D+ + + + EK
Sbjct: 1264 LHAKVSEGDRL--------RVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES 1315
Query: 906 ---EMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 937
+ +ELL+E + K + ++I+QL N +Q+
Sbjct: 1316 QLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Score = 92.4 bits (228), Expect = 2e-18
Identities = 139/647 (21%), Positives = 285/647 (44%), Gaps = 83/647 (12%)
Query: 305 PMLQESEKPKTEIIKVDQSHSEDNTYQSLVE-QLDQEREKRWRAEQAENKLMDYIDELHK 363
P+LQ + + + E+ D+ + Q+ VE +L++ K + + +N L + + +
Sbjct: 843 PLLQVTRQEE-ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901
Query: 364 HANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQED 423
E E++ + L+EI+ + + E LQNE KK+
Sbjct: 902 LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQA----------- 950
Query: 424 HLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQ 483
H++ LE+ L++ E +++ Q ++ E K + EI LL + ++ +
Sbjct: 951 ---HIQDLEEQLDEEEGARQKLQLEKV----TAEAKIKKMEEEILLLEDQNSKFIKEKKL 1003
Query: 484 LHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQY 543
+ +A + +E E AK +AK K E MI + +E++ +
Sbjct: 1004 MEDRIAECSSQLAEEEEK-------------AKNLAKIRNKQEVMISDLEERLKKEEKTR 1050
Query: 544 MDLENEFRIALTVEARRFQD----VKDGFENVATELAKSKHALIWAQRKENESSSLIKDL 599
+LE R L E QD ++ + + +LAK + L A + ++ + +
Sbjct: 1051 QELEKAKR-KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNA 1109
Query: 600 TCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISEL 659
+V+E + ++AE+ QE + + N E + + S ++E LK E +
Sbjct: 1110 LKVVRELQAQIAEL----QEDFESEKASRNKAE---KQKRDLSEELEALKTELEDTLDTT 1162
Query: 660 AAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESL-SRENECLRKTNESDSDA 718
AA++ LRT+R+ E+A+ +L + EAQI+ + R L + +E A
Sbjct: 1163 AAQQE----LRTKRE---QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQA 1215
Query: 719 LRIKCKIIDDQ--TETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVL 776
R K + ++ ET K C +K LQ+ E E K +LD +
Sbjct: 1216 KRFKANLEKNKQGLETDNKELAC------EVKVLQQVKAESE--------HKRKKLDAQV 1261
Query: 777 EKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKG----ELLCHLETQVKEVK 832
++L ++L+ +L K +L+ STL + KG + LE+Q+++ +
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321
Query: 833 E--KFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQ 890
E + E ++K + R + +E +KN++++ ++ ++ ++ V A Q +QLA+ K+
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ---SQLADTKK 1378
Query: 891 KCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 937
K D + +E+ ++LL K+ + + ++++ A A +++++
Sbjct: 1379 KVDDDLG-TIESLEEAKKKLL----KDAEALSQRLEEKALAYDKLEK 1420
Score = 87.0 bits (214), Expect = 7e-17
Identities = 148/723 (20%), Positives = 304/723 (42%), Gaps = 103/723 (14%)
Query: 264 AKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPKTEIIKVDQS 323
A+ + ++ KN+ + + R+ L+EL L+++++ K + K Q
Sbjct: 1177 AELKKALEEETKNHEAQIQDMRQRHATALEEL--------SEQLEQAKRFKANLEKNKQG 1228
Query: 324 HSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLK 383
DN + L ++ ++ + +E KL + ELH +E + + +L+
Sbjct: 1229 LETDN--KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQ 1286
Query: 384 E------IIFRERNSKG-QLEVMVHKLQNEIKKLTVELMKAKDQQEDHLK-HLRTLEKTL 435
+ E KG + L+++++ T EL++ + +Q+ +L +R LE+
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQD-TQELLQEETRQKLNLSSRIRQLEEEK 1345
Query: 436 EKMERQKRQQQAAQIRLIQEV-ELKASAADRE---------IYLLRTSLHREREQAQQLH 485
++ Q+ +++ A+ L ++V L++ AD + I L + + + A+ L
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405
Query: 486 QLLA--------LKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE------ 531
Q L L++ ++R + E + D D Q +A + K++KK +Q++ E
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 532 -YQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQ---- 586
Y E+ D + + E + ++L + K+ FE +L L+ ++
Sbjct: 1466 RYAEERDRAEAEAREKETK-ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524
Query: 587 RKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETA-ANLQNQINTLEILIEDDKQKSIQI 645
+ +E + L V+E +T+L E+ Q T A L+ ++N + + ++ +
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRD 1584
Query: 646 ELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSREN 705
E + +K LI ++ E+ L ERK +A + + + LEAQIE+ ++
Sbjct: 1585 EQNEEKKRLLIKQVRELEA---ELEDERKQRALAVASK-KKMEIDLKDLEAQIEAANKAR 1640
Query: 706 E----CLRKTNESDSDALR-------IKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKI 754
+ LRK D R + +I E+ +KLK E I +LQE++
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAE----ILQLQEEL 1696
Query: 755 TEIEKCTQEQLDEKSSQLDEVLEKLERHN---ERKEKLKQQLKGKEVELEEIRKAYSTLN 811
E+ + E+ DE+ + + K +L+ ++ E ELEE + LN
Sbjct: 1697 ASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLN 1756
Query: 812 RKWHDKGELLCHLETQV---KEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFK 868
++ + L ++ + +K +N ++L+ + K KL ++ A K
Sbjct: 1757 DRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQN-------KELKAKLQELEGAVK 1809
Query: 869 RQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEM-RELLEETCKNK--KTMEAKI 925
+ A + A +A+I QL E+++ +E E NK + E K+
Sbjct: 1810 SKFKATISALEAKIGQL------------------EEQLEQEAKERAAANKLVRRTEKKL 1851
Query: 926 KQL 928
K++
Sbjct: 1852 KEI 1854
Score = 79.0 bits (193), Expect = 2e-14
Identities = 133/676 (19%), Positives = 290/676 (42%), Gaps = 82/676 (12%)
Query: 180 FMSVCQSSEPEKNNHENDLQNEIKLQKLD-DQILQLLNETSNSIDNVLEKDPRPKRDTD- 237
F S E + + + LQ E + QKL+ ++ L E NS+ E++ +++ +
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETR-QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364
Query: 238 --ITSESDYGNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKEL 295
+ +S + K+ K+ D TI++++ K L +
Sbjct: 1365 QVLALQSQLADTKK---------KVDDDLGTIESLEEAKKKLLKDAEA--------LSQR 1407
Query: 296 YVSSSLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLM 355
+LA + EK K + + + D +Q V ++++K++ AE K +
Sbjct: 1408 LEEKALA----YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSI 1463
Query: 356 D--YIDELHKHANEKEDIHSLALLTTDRLKEIIFR----ERNSKGQLEVMVHKL---QNE 406
Y +E + E + + AL L+E + ER +K QL + L +++
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK-QLRADMEDLMSSKDD 1522
Query: 407 IKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADRE 466
+ K EL K+K E ++ +RT LE++E + + + A++RL EV ++A A E
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRT---QLEELEDELQATEDAKLRL--EVNMQAMKAQFE 1577
Query: 467 IYLLRTSLHREREQA---QQLHQLLALKEQEHRK-----------ELETREFFTDADFQD 512
L E ++ +Q+ +L A E E ++ E++ ++ + +
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN 1637
Query: 513 ALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVA 572
E+ K+ +K + +K+YQ +++ +E ++ + ++ +
Sbjct: 1638 KARDEVIKQLRKLQAQMKDYQRELEEARAS----RDEIFAQSKESEKKLKSLEAEILQLQ 1693
Query: 573 TELAKSKHALIWAQRKENESSSLIKDL----TCMVKEQKTKLAEVSKLKQETAANLQNQI 628
ELA S+ A A+++ +E + I + + ++ E++ A +++L++E L+ +
Sbjct: 1694 EELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE----LEEEQ 1749
Query: 629 NTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLA 688
+ +E+L + ++ ++Q++ L +ELAA+ S R+ + + + L
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLN-------AELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 689 QNRG----KLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKD 744
+ G K +A I +L + L + E ++ K++ T +KLK+ + +
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV---RRTEKKLKEIFMQVE 1859
Query: 745 EHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIR 804
+ + + ++EK ++ + QL+E E+ R N + KL+++L E +
Sbjct: 1860 DERRHADQYKEQMEKANA-RMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLS 1918
Query: 805 KAYSTLNRKWHDKGEL 820
+ STL + G +
Sbjct: 1919 REVSTLKNRLRRGGPI 1934
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 98.2 bits (243), Expect = 3e-20
Identities = 172/808 (21%), Positives = 340/808 (42%), Gaps = 148/808 (18%)
Query: 247 RKECNRKVPRRSKI---PYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLAN 303
R E + V RR I Y+ ++ +KH ++ K+KP LK +A
Sbjct: 799 RVEFQKMVQRRESIFCIQYNIRSFMNVKHW-----PWMKLFFKIKP-LLKSAETEKEMAT 852
Query: 304 CPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHK 363
M +E +K K E+ K + E + LV + ++ + + + + L+D + +
Sbjct: 853 --MKEEFQKTKDELAKSEAKRKE--LEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQ 908
Query: 364 HANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLT-----VELMKAK 418
K + + T+R ++ E +L KL++E +L +EL AK
Sbjct: 909 LIKAKFQLEAKIKEVTERAED----EEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964
Query: 419 DQQEDHL---------KHLRTLEKTLEKMERQKRQQQAA--------------------- 448
++E H + L L++T+ K+ R+K+ Q A
Sbjct: 965 VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKT 1024
Query: 449 QIRLIQEVELKASAADREIYLLRTSLHREREQAQ---QLHQLLALKEQEHRKELETREFF 505
+ +L Q+VE S+ ++E LR L R + + + +L Q L + +++L+ R
Sbjct: 1025 KSKLEQQVEDLESSLEQE-KKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER--L 1081
Query: 506 TDADFQDALAKEIAKEEK----KHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVE---- 557
DF+ + ++E+ + ++ IKE Q +I+ L ++ ++ E R +
Sbjct: 1082 KKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE-IEAERATRAKTEKQRSDY 1140
Query: 558 ARRFQDVKD------GFENVATELAKSKHALIWAQRKENESSSLIKD--LTCMVKEQKTK 609
AR +++ + G + EL K + A R++ E ++L + + + K+
Sbjct: 1141 ARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADS 1200
Query: 610 LAEVS-----------KLKQETA--------------------ANLQNQINTLEILIEDD 638
+AE+ KL++E + ANL+ TLE + +
Sbjct: 1201 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEA 1260
Query: 639 KQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQG---SSLAQNRGKLE 695
+ K+ +I+ + +SEL ++S L+TE +L ++ S L++++
Sbjct: 1261 RGKNEEIQ-------RSLSELTTQKS---RLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310
Query: 696 AQIESLSRENECLRKTNESDSDAL---RIKCKIIDDQTETIRKLKDCLQE---------- 742
Q E L R+ E K + + AL R C ++ +Q E ++ K LQ
Sbjct: 1311 QQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370
Query: 743 ------KDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGK 796
+ + I+R +E + E +K ++L + Q++ V K + K++L+ +++
Sbjct: 1371 QWRTKYETDAIQRTEE-LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL 1429
Query: 797 EVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIEL--QK 854
V++E + L++K + ++L +T+ +E + + E LK R S EL K
Sbjct: 1430 MVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAEL---EASLKESRSLSTELFKLK 1486
Query: 855 NAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMREL---L 911
NA E+ + KR+ + +E A++ + E K I QIE E ++ L
Sbjct: 1487 NAYEEALDQLETVKRE-NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLAL 1545
Query: 912 EETCKNKKTMEAKIKQLAFALNEIQQDM 939
EE + EAKI ++ L +++ ++
Sbjct: 1546 EEAEAALEHEEAKILRIQLELTQVKSEI 1573
Score = 97.1 bits (240), Expect = 7e-20
Identities = 142/693 (20%), Positives = 296/693 (42%), Gaps = 107/693 (15%)
Query: 308 QESEKPKTEI-IKVDQSHSE-----------DNTYQSLVEQLDQEREKRWRAEQA----- 350
Q+ EK K+E +++D S + ++L +QL + R K +++
Sbjct: 1216 QKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELT 1275
Query: 351 --ENKLMDYIDELHKHANEKEDIHSLALLT-------TDRLKEIIFRERNSKGQLEVMVH 401
+++L EL + EKE I S + T+ LK + E +K L H
Sbjct: 1276 TQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNAL---AH 1332
Query: 402 KLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVE-LKA 460
LQ+ + + +++QE + R L K ++ + + + + I+ +E+E K
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1392
Query: 461 SAADREIYLLRTSLHREREQAQQLHQLLA-LKEQEHRKELETREFFTDADFQDALAKEIA 519
A R L EQ + ++ A L++ + R + E + D + ++LA +
Sbjct: 1393 KLAQR--------LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALD 1444
Query: 520 KEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSK 579
K+++ ++++ E++ K + + +LE + + ++ F+ +K+ +E +L K
Sbjct: 1445 KKQRNFDKVLAEWKTKCE---ESQAELEASLKESRSLSTELFK-LKNAYEEALDQLETVK 1500
Query: 580 HALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETA---ANLQNQINTLEILIE 636
R+ I DLT + E + E+ K +++ A++Q + E +E
Sbjct: 1501 -------RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALE 1553
Query: 637 DDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEA 696
++ K ++I+L E Q+ SE+ K +A++ + Q + +
Sbjct: 1554 HEEAKILRIQL---ELTQVKSEIDRK-----------------IAEKDEEIEQLKRNYQR 1593
Query: 697 QIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITE 756
+E++ L S ++A+R+K K+ D E +L ++ E +K L+ +
Sbjct: 1594 TVETMQ---SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQ 1650
Query: 757 IEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHD 816
+ K TQ LD+ +++ E+L R L+ +++ LE+ +A ++ D
Sbjct: 1651 L-KDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLD 1709
Query: 817 KGELLCHLETQ---VKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHS-------MDDA 866
E + L TQ + K+K E +L++E + + +NA EK M +
Sbjct: 1710 SNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEE 1769
Query: 867 FKRQVD--AIVEAHQAEIAQLANEKQKCIDSA--------NLKVHQIEKEMREL---LE- 912
K++ D A +E + + Q + Q +D A ++ ++E +REL LE
Sbjct: 1770 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEG 1829
Query: 913 ------ETCKNKKTMEAKIKQLAFALNEIQQDM 939
E+ K + E ++K+L + E ++++
Sbjct: 1830 EQKKNTESVKGLRKYERRVKELTYQSEEDRKNV 1862
Score = 77.0 bits (188), Expect = 8e-14
Identities = 161/874 (18%), Positives = 355/874 (40%), Gaps = 146/874 (16%)
Query: 132 DNLVSSDSPLNISEDEII-------DRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVC 184
D L S++ E++++ D + A + L+ E+ A +
Sbjct: 862 DELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIK 921
Query: 185 QSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSES-- 242
+ +E ++ E + + K +KL+D+ +L + + ++ L K + K T+ ++
Sbjct: 922 EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD-LELTLAKVEKEKHATENKVKNLT 980
Query: 243 -DYGNRKECNRKVPRRSKIPYDA--KTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSS 299
+ E K+ R K +A + + ++ NS K++ +++L S
Sbjct: 981 EELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQ-VEDL--ES 1037
Query: 300 SLANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYID 359
SL E EK ++ ++ E + + LD E +K+ E+ + K +Y
Sbjct: 1038 SL-------EQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQ 1090
Query: 360 ELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKD 419
K ED +L L ++KE L+ + +L+ EI+ K +
Sbjct: 1091 LQSK----VEDEQTLGLQFQKKIKE-----------LQARIEELEEEIEAERATRAKTEK 1135
Query: 420 QQEDHLKHLRTLEKTLEKME-------RQKRQQQAAQIRLIQEVELKASAADREIYLLRT 472
Q+ D+ + L L + LE+ ++++A ++L +++E + + LR
Sbjct: 1136 QRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRK 1195
Query: 473 SLHRER--EQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIK 530
H + E +Q+ L +K+ + E E EF + D + + ++K + E++ +
Sbjct: 1196 K-HADSVAELGEQIDNLQRVKQ---KLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICR 1251
Query: 531 EYQEKIDVLSQQYMDLENEF------RIALTVEARRFQDVKDGFENVATELAKSKHALIW 584
++++ + +++ + L EA + E++ ++L++SK A
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAF-- 1309
Query: 585 AQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQ 644
T +E K +L E +K K A LQ+ + ++L E Q
Sbjct: 1310 ---------------TQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE-------Q 1347
Query: 645 IELLKHEKVQLISELAAKESLIFGLRTERKVWG----HELAQQGSSLAQNRGKLEAQIES 700
E + K +L L+ S + RT+ + EL + LAQ E Q+E+
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407
Query: 701 LSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRL--------QE 752
++ + L KT + L+ + + + E L L +K + ++ +E
Sbjct: 1408 VNAKCASLEKTKQR----LQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEE 1463
Query: 753 KITEIEKCTQE------QLDEKSSQLDEVLEKLERHNERKEKLKQQLKG----------- 795
E+E +E +L + + +E L++LE + L+Q++
Sbjct: 1464 SQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKT 1523
Query: 796 --------KEVELEE------IRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKK 841
K++ELE+ + +A + L H++ ++L ++ ++ +VK + + K
Sbjct: 1524 IHELEKSRKQIELEKADIQLALEEAEAALE---HEEAKIL-RIQLELTQVKSEIDRK--- 1576
Query: 842 LKAERDKSIE-LQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKV 900
AE+D+ IE L++N + +M A +V + + E +L + + ++ +++
Sbjct: 1577 -IAEKDEEIEQLKRNYQRTVETMQSALDAEVRS-----RNEAIRLKKKMEGDLNEIEIQL 1630
Query: 901 HQIEKEMRELLEETCKNKKTMEAKIKQLAFALNE 934
++ ET K+ ++++ ++K L++
Sbjct: 1631 SHANRQ----AAETLKHLRSVQGQLKDTQLHLDD 1660
Score = 67.8 bits (164), Expect = 5e-11
Identities = 112/512 (21%), Positives = 209/512 (40%), Gaps = 81/512 (15%)
Query: 307 LQESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHAN 366
L+ES TE+ K+ N Y+ ++QL+ + + EQ L + I E K +
Sbjct: 1472 LKESRSLSTELFKLK------NAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIH 1525
Query: 367 EKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVEL---MKAKDQQED 423
E E L ++ + + E + ++Q E+ ++ E+ + KD++ +
Sbjct: 1526 ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIE 1585
Query: 424 HLK--HLRTLEKTLEKMERQKRQQQAAQIRL-------IQEVELKASAADREIYLLRTSL 474
LK + RT+E ++ + R + A IRL + E+E++ S A+R+ T
Sbjct: 1586 QLKRNYQRTVETMQSALDAEVRSRNEA-IRLKKKMEGDLNEIEIQLSHANRQA--AETLK 1642
Query: 475 HREREQAQ----QLHQLLALKEQEHRKE----LETREFFTDADFQD--ALAKEIAKEEKK 524
H Q Q QLH AL+ QE KE +E R A+ ++ A ++ + K
Sbjct: 1643 HLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKL 1702
Query: 525 HEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIW 584
EQ + + E++ +L Q L + + T + +V+D +
Sbjct: 1703 AEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRD-------------- 1748
Query: 585 AQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQ 644
A+ E ++ I D M +E K + Q+T+A+L+ LE ++D + + +
Sbjct: 1749 ARNAEEKAKKAITDAAMMAEELKKE--------QDTSAHLERMKKNLEQTVKDLQHRLDE 1800
Query: 645 IE--LLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLS 702
E LK K Q+ L F L E+K + + + K E +++ L+
Sbjct: 1801 AEQLALKGGKKQIQKLETRIRELEFELEGEQK--------KNTESVKGLRKYERRVKELT 1852
Query: 703 RENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQ 762
++E E + LR++ L D LQ K + KR E+ E
Sbjct: 1853 YQSE------EDRKNVLRLQ------------DLVDKLQVKVKSYKRQAEEADEQANAHL 1894
Query: 763 EQLDEKSSQLDEVLEKLERHNERKEKLKQQLK 794
+ + +L+E E+ + + KL+ + +
Sbjct: 1895 TKFRKAQHELEEAEERADIAESQVNKLRAKTR 1926
Score = 32.3 bits (72), Expect = 2.1
Identities = 36/146 (24%), Positives = 67/146 (45%), Gaps = 14/146 (9%)
Query: 327 DNTYQSLVEQLDQEREKRWRAEQAE-NKLMDYIDELH--KHANEKEDIHSLALLTT--DR 381
+ T + L +LD+ + + + + KL I EL +K++ S+ L R
Sbjct: 1788 EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERR 1847
Query: 382 LKEIIFR---ERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKM 438
+KE+ ++ +R + +L+ +V KLQ ++K + +A +Q HL R + LE+
Sbjct: 1848 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEA 1907
Query: 439 ERQKRQQQAAQIRLIQEVELKASAAD 464
E + A I Q +L+A D
Sbjct: 1908 E------ERADIAESQVNKLRAKTRD 1927
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 97.8 bits (242), Expect = 4e-20
Identities = 120/602 (19%), Positives = 268/602 (44%), Gaps = 53/602 (8%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANE 367
QE E + E Q E Q E+L ++R++ W+ + + + H E
Sbjct: 144 QERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQE-WQEREERRAEEEQLQSCKGHETE 202
Query: 368 K----EDIHSLALLTTDRL------------KEIIFRERNSKGQLEVMVHKLQNEIKKLT 411
+ E + LL R ++ +F+E K + L+ E +KL
Sbjct: 203 EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEK-EWRKRETVLRKEEEKLQ 261
Query: 412 VELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLR 471
E + + + ++ + LR LE+ + ERQ+ +QQ ++R Q++ K RE R
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 472 TSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKE 531
REQ ++ + +EQE R+E + R + + L +E +EE++ +Q+ +E
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE-QEEERREQQLRRE 380
Query: 532 YQEKIDVLSQQYMDLENEFRIALTVEARRFQDVK-----DGFENVATELAKSKHALIWAQ 586
Q + + ++ L E ++ + RR Q ++ + + E + +H Q
Sbjct: 381 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 587 RKENESSSLIKD--LTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQ 644
+ + ++ + +E++T+ E + KQ+ + + + + +E+++++ Q
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Query: 645 IELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRE 704
+ + QL E + R +R+ L Q+ S Q R + E + E L +
Sbjct: 501 ----ERREQQLRREQEERRE----QRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Query: 705 NECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQE--KDEHIKRLQEKI--TEIEKC 760
E K E + R+K + + + + +++ ++ Q+ K E +RL++++ E+E+
Sbjct: 553 EE--EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERL 610
Query: 761 TQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGEL 820
QE+ E ++L+R +E+ +Q LK +E E + L R+ ++ E
Sbjct: 611 EQEERRE---------QRLKREEPEEERRQQLLKSEEQE----ERRQQQLRREQQERREQ 657
Query: 821 LCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQA 880
E + + ++++ + + ++ + E++ + E Q+ A E++ S ++ Q+++ +A Q+
Sbjct: 658 RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717
Query: 881 EI 882
++
Sbjct: 718 KV 719
Score = 80.5 bits (197), Expect = 7e-15
Identities = 149/771 (19%), Positives = 307/771 (39%), Gaps = 109/771 (14%)
Query: 187 SEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGN 246
SE ++ + L+ E Q+ +Q L+ E + + +R+ ++ E
Sbjct: 636 SEEQEERRQQQLRRE--QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA 693
Query: 247 RKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPM 306
R+ ++P+ Q + + S RK + ++
Sbjct: 694 RERIKSRIPKWQW--------QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745
Query: 307 LQESEKPKTEIIKVDQSHSEDNTYQSLVEQ--------------LDQEREKRWRAEQAEN 352
LQ E+ + + ++ D T+Q E+ L ++RE++ RAE+ +
Sbjct: 746 LQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ 805
Query: 353 KLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTV 412
+ ++ E + + +R KE+ F E + Q +LQ E L
Sbjct: 806 REQRFLPEEEEKEQRRRQ-------RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 413 ELMKAKDQ------------QEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKA 460
+ + + Q +E+ + TL E+ +++QQ Q +E EL+
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ---EEEEELQR 915
Query: 461 SAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELE-TREFFTDADFQDALAKEIA 519
++ + +RE EQ QQ + L +E+E R+ E R++ D Q + +
Sbjct: 916 EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 520 K--EEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAK 577
+ E+++ ++ K+Y+E+ + L Q+ L E R E RR Q+ + + EL +
Sbjct: 976 EEPEKRRRQEREKKYREE-EELQQEEEQLLREER-----EKRRRQEWERQYRK-KDELQQ 1028
Query: 578 SKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIED 637
+ L+ R+E E L +E++ + E +L+QE L + T
Sbjct: 1029 EEEQLL---REEREKRRL--------QERERQYREEEELQQEEEQLLGEERET------- 1070
Query: 638 DKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQ 697
+++ ++ + K E++Q E +E R ER+ + +L+ +
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE-----------RQCREEEELQQE 1119
Query: 698 IESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEI 757
E L RE R+ E + R+ ++ QE+++ ++ EK
Sbjct: 1120 EEQLLREEREKRRRQELE---------------RQYREEEEVQQEEEQLLREEPEKRRRQ 1164
Query: 758 EKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDK 817
E Q + +E+ Q +E L + E+ R+E+ +Q + +E++ ++ ++ Y +++ K
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 818 GELLCHLETQVKEVK--------EKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKR 869
+ E V++ K E+F E +R +LQ + + + D +R
Sbjct: 1225 WQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ-HLLGEQQERDREQER 1283
Query: 870 QVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKT 920
+ + H E QL E+QK + K + ++ +RE EE + ++T
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Score = 76.3 bits (186), Expect = 1e-13
Identities = 154/789 (19%), Positives = 309/789 (39%), Gaps = 95/789 (12%)
Query: 195 ENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNRKECNRKV 254
E + E ++Q+ ++Q+L+ E LE+ R + ++ E + R+E ++
Sbjct: 1137 ERQYREEEEVQQEEEQLLR--EEPEKRRRQELERQYR--EEEELQQEEEQLLREEQEKRR 1192
Query: 255 PRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPMLQESEKPK 314
R + + + +Q K + + + K + KE V + C + + +
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252
Query: 315 TEIIKVDQSHSEDNTYQSLVEQLDQERE---KRW--------------RAEQAENKLMDY 357
E ++ S+ + L EQ +++RE +RW R EQ E K D
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312
Query: 358 IDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQ-LEVMVHKLQNEIKKLTVELMK 416
+ K +E TDR FRE Q E + Q +K E ++
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRK----FREEEQLLQEREEQPLRRQERDRKFREEELR 1368
Query: 417 AKDQ------QEDHLKHLRTLEKTLEKMER---QKRQQQAAQIR----LIQEVELKASAA 463
++Q +E L+ K L++ ++ Q+R+QQ Q R +E +L
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428
Query: 464 DREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEK 523
DR+ + R+ + + L + L+++ HRK E + + + Q +E ++
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488
Query: 524 KHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHA-- 581
+ EQ ++ + Q+ E E + + Q + F +L + +
Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQ 1548
Query: 582 -------------LIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQI 628
+ +R+E + S +D ++EQK + E + E L+ Q
Sbjct: 1549 RRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQE 1608
Query: 629 NTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLA 688
++ E D++ +LL+ + Q +L +E L E ++ E QQ L
Sbjct: 1609 GQQQLRQERDRKFREDEQLLQEREEQ---QLHRQERDRKFLEEEPQLRRQEREQQ---LR 1662
Query: 689 QNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIK 748
+R + + E L +E E + + R + + + Q R+ K +E+ +
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQE---RERKFLQEEQQLRRQ 1719
Query: 749 RLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKE----------- 797
L+ K E E+ QE E+ + + + LE R E+ +QQL+ +E
Sbjct: 1720 ELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQL 1779
Query: 798 -VELEEIRKAYSTLNRKWHDKGELLCHLETQV------------KEVKEKFENKEKKLKA 844
E EE + +RK+ ++ +L E Q +E + + E +E++L+
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839
Query: 845 ERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIE 904
ERD+ Q A E+ + + + + + E Q E + E+++ + +++ Q E
Sbjct: 1840 ERDR----QYRAEEQFATQEKSRREE----QELWQEEEQKRRQERERKLREEHIRRQQKE 1891
Query: 905 KEMRELLEE 913
++ + E
Sbjct: 1892 EQRHRQVGE 1900
Score = 75.1 bits (183), Expect = 3e-13
Identities = 117/603 (19%), Positives = 267/603 (44%), Gaps = 59/603 (9%)
Query: 330 YQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRE 389
Y +L + + EKR R + E+ L D E + E D +L+E +
Sbjct: 86 YYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRD---------RQLEEEPGQR 136
Query: 390 RNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMER--QKRQQQA 447
R K Q E + E + E ++ +D+Q + R ++ E+ ER ++ Q Q+
Sbjct: 137 RRQKRQ-EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQS 195
Query: 448 AQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTD 507
+ +E + RE+ LR E++Q ++ Q +E+E KE RE
Sbjct: 196 CKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE-EKEWRKRETVLR 254
Query: 508 ADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDG 567
+ +++ +EE + ++ ++E +E++ L +Q + E + RR Q ++
Sbjct: 255 KE-----EEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK 309
Query: 568 FENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQ 627
E E + + +R+E + +EQ+ + + + +Q+ + +
Sbjct: 310 QEEERREQQEERRE--QQERREQQEER---------REQQLRREQEERREQQLRREQEEE 358
Query: 628 INTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSL 687
++ E ++++ Q +L + ++++ +L ++ LR E+++ + ++ L
Sbjct: 359 RREQQLRREQEEERREQ-QLRREQQLRREQQLRREQQ----LRREQQLRREQQLRREQQL 413
Query: 688 AQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI 747
+ + Q L RE E + +E + R + ++ +Q E +D L+ ++E
Sbjct: 414 RREQQLRREQ--QLRREQE--EERHEQKHEQERREQRLKREQEER----RDWLKREEETE 465
Query: 748 KRLQE-KITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKA 806
+ QE + ++++ +E+ E+ +L+E E E++E+ +QQL+ ++ E E R
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEE-----EERREQQERREQQLRREQEERREQRL- 519
Query: 807 YSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDA 866
++ ++ L L ++ + +E+ E +E+ LK E +K +E ++ ++
Sbjct: 520 -----KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE- 573
Query: 867 FKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEK-EMRELLEETCKNKKTMEAKI 925
R+ + + +L E+++ ++ LK ++E+ E E E+ K ++ E +
Sbjct: 574 --RRDQLLKREEERRQQRLKREQEERLEQ-RLKREEVERLEQEERREQRLKREEPEEERR 630
Query: 926 KQL 928
+QL
Sbjct: 631 QQL 633
Score = 74.3 bits (181), Expect = 5e-13
Identities = 129/649 (19%), Positives = 276/649 (42%), Gaps = 77/649 (11%)
Query: 336 QLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQ 395
Q DQER +R + ++ + K ++E K L L+E + +E+ +
Sbjct: 857 QEDQER-RRSQEQRRDQKWRWQLEEERKRRRH-------TLYAKPALQEQLRKEQQLLQE 908
Query: 396 LEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQE 455
E + + + E ++ + + +++++ + + L + EK RQ+R++Q + + +Q+
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 456 VE--LKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDADFQDA 513
E L ++ R +RE E+ QQ + L +E+E R+ E + D
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 514 LAKEIAKEEKKH---EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFEN 570
+++ +EE++ ++ ++Y+E+ + L Q+ L E R E RR Q+++ +
Sbjct: 1029 EEEQLLREEREKRRLQERERQYREE-EELQQEEEQLLGEER-----ETRRRQELERQYRK 1082
Query: 571 VATELAKSKHALIWAQ-----RKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQ 625
EL + + L+ + R+E E ++ +EQ + + +QE +
Sbjct: 1083 -EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 626 NQINTL---EILIEDDKQKSIQIEL---------LKHEKVQLISELAAKESLIFGLRTER 673
+ E L+ ++ +K + EL L+ E+ QL+ E K R ER
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKR------RQER 1195
Query: 674 KVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDSDALRIKCKIIDDQTETI 733
+ E + + R + E Q L + E ++ D+ ++ CK + E
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDN---KVYCK--GRENEQF 1250
Query: 734 RKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVL---EKLERHNERKEKLK 790
R+L+D + + LQ + E ++ +EQ + Q D E+LER +++ K +
Sbjct: 1251 RQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR 1310
Query: 791 QQLKGKEVEL-----EEIRKAYSTLNRKWHDKGELLCHLETQV----------------- 828
+ +E +L EE R+ T +RK+ ++ +LL E Q
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQET-DRKFREEEQLLQEREEQPLRRQERDRKFREEELRH 1369
Query: 829 KEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANE 888
+E KF +E++L+ + + L++ + + ++ D + ++++ E
Sbjct: 1370 QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR--QE 1427
Query: 889 KQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQ 937
+ + +V + E+E R+ LEE + ++ K ++ L E ++
Sbjct: 1428 RDRKFREEEQQVRRQERE-RKFLEEEQQLRQERHRKFREEEQLLQEREE 1475
Score = 60.8 bits (146), Expect = 6e-09
Identities = 133/672 (19%), Positives = 284/672 (42%), Gaps = 91/672 (13%)
Query: 189 PEKNNHENDLQNEIKLQ-KLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDYGNR 247
PE+ E + Q E K + + + QLL E ++ R +++TD +
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREE--------REEKRRRQETDRKFREEEQLL 1345
Query: 248 KECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPPYLKELYVSSSLANCPML 307
+E + RR + D K + H + F+ ++++ + + L
Sbjct: 1346 QEREEQPLRRQE--RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKF----------L 1393
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLVEQLD-QEREKRWRAEQA-------ENKLMDYID 359
+E ++ + + + D ++ +QL QER++++R E+ E K ++
Sbjct: 1394 KEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQ 1453
Query: 360 EL----HKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELM 415
+L H+ E+E LL +++ +ER+ K E + Q +K + +
Sbjct: 1454 QLRQERHRKFREEEQ-----LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL 1508
Query: 416 KAKDQQEDHLKHLRTLEKTLEKMERQKR-QQQAAQIRLIQEVELKASAADREIYLLRTSL 474
++++ + L+ E+ L + +RQ++ Q+ Q+R + + + DR+ + L
Sbjct: 1509 RSQEPERKFLEE----EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK-FREEEQL 1563
Query: 475 HREREQAQQLHQ----LLALKEQEHRKELETREFFTDA------DFQDALAKEIAKEEKK 524
+ERE+ Q Q L+EQ+ R++ + R+F D + Q L +E ++ ++
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Query: 525 HEQMIKEYQEKIDVLSQQYMD---LENEFRIALTVEARRFQDVKDG-FENVATELAKSKH 580
EQ+++E +E+ L +Q D LE E ++ ++ + +D F L + +
Sbjct: 1624 DEQLLQEREEQ--QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681
Query: 581 ALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQ 640
+ Q ++ + + L +E+K E +QE + + E +Q
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREE--------EQLRQ 1733
Query: 641 KSIQIELLKHEKVQLISELAA-----KESLIFGLRTERKVWGHELAQQGSSLAQNRGKLE 695
++ Q +L + E+ + I E +E + +RK E +Q Q R +
Sbjct: 1734 ETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ-- 1791
Query: 696 AQIESLSRENECLRKTNESDSDALRI-----KCKIIDDQTETIRKLKDCLQEKDEHIKRL 750
+ + RE E LR+ E + LR K + ++Q + + + QE+D +
Sbjct: 1792 -ESDRKFREEEQLRQ--EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR-- 1846
Query: 751 QEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQ-LKGKEVELEEIRKAYST 809
E + TQE+ + +L + E+ +R ER+ KL+++ ++ ++ E + R+
Sbjct: 1847 ----AEEQFATQEKSRREEQELWQE-EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEI 1901
Query: 810 LNRKWHDKGELL 821
+++ G LL
Sbjct: 1902 KSQEGKGHGRLL 1913
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 97.4 bits (241), Expect = 5e-20
Identities = 143/690 (20%), Positives = 301/690 (43%), Gaps = 93/690 (13%)
Query: 298 SSSLANCPMLQESEKP----KTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENK 353
SS + C + + KP + E VD S+SE S E E + +
Sbjct: 115 SSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE---- 170
Query: 354 LMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVE 413
I+EL++ E + T+ L+++ + E + + I +LT
Sbjct: 171 ----IEELNRELEEMRVTYG-----TEGLQQL--------QEFEAAIKQRDGIITQLTAN 213
Query: 414 LMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTS 473
L +A+ ++++ ++ L + +K++ Q +Q QA++ ++ ++AAD LL+
Sbjct: 214 LQQARREKDETMREFLELTEQSQKLQIQFQQLQASET--LRNSTHSSTAAD----LLQAK 267
Query: 474 LHREREQAQQLHQLLALKEQEHRKELETREF-FTDADFQDALAKEIAKEEKKHEQMIKEY 532
Q Q Q L++ + +KE T + F + ++ K E +++ I+E
Sbjct: 268 QQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK 327
Query: 533 QEKIDVLSQQYMDLEN---EFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKE 589
+ I+ L+ + ++ E E + LT + ++++ E+ K L +++KE
Sbjct: 328 ETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKE 387
Query: 590 NESSSLIKDLTCMVKEQKTKLAE--------VSKLKQETAANLQNQINTLEILIEDDKQK 641
+SS IK L V+E + + + V +++QET L+ ++ E D+
Sbjct: 388 RQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLE------QLRAELDEMY 441
Query: 642 SIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESL 701
QI +K E ++ +A E + +T K + S++ N +++ ++
Sbjct: 442 GQQIVQMKQELIR--QHMAQMEEM----KTRHKGEMENALRSYSNITVNEDQIKLMNVAI 495
Query: 702 SRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKD---EHIKRLQEKITEIE 758
+ N L+ TN I++++ R+L+D ++E E I+R ++ I E E
Sbjct: 496 NELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE 555
Query: 759 KCTQEQLDEKSSQLD---EVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYST-LNRKW 814
E S+ D E++ E E + K + ++ +++LE + K + L+R
Sbjct: 556 SKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMA 615
Query: 815 HDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAI 874
+ L L TQ+ F ++E+ K + D IE + N + ++ +K+Q+D +
Sbjct: 616 ESQEAELERLRTQLL-----FSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGL 670
Query: 875 -------VEAHQ--------------AEIAQLANEKQKCIDSAN----LKVHQIEKEMRE 909
+E Q EI++L + +Q ++S + L++++++KE+ E
Sbjct: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI-E 729
Query: 910 LLEETCKNKKTMEAKIKQLAFALNEIQQDM 939
+L + K K T+E ++++L +++ M
Sbjct: 730 ILRQEEKEKGTLEQEVQELQLKTELLEKQM 759
Score = 94.7 bits (234), Expect = 3e-19
Identities = 137/663 (20%), Positives = 290/663 (43%), Gaps = 74/663 (11%)
Query: 308 QESEKPKTEIIKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANE 367
Q+ + + +++ Q ED T Q QE+ K + EQ + +E+ +
Sbjct: 274 QQQLEEQDHLLEDYQKKKEDFTMQI---SFLQEKIKVYEMEQDKKVENSNKEEIQEKETI 330
Query: 368 KEDIHSLAL---LTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDH 424
E++++ + T LK+ + G+L+ + + EIK + +EL +K ++
Sbjct: 331 IEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQS 390
Query: 425 LKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQL 484
+ ++ L T+E+++++ + + ++Q +E R++ LR L + QQ+
Sbjct: 391 SEEIKQLMGTVEELQKRNHKDSQFETDIVQRME---QETQRKLEQLRAEL--DEMYGQQI 445
Query: 485 HQLLALKEQEHRKELETREFFTDADFQDALA--KEIAKEEKKHEQM---IKEYQEKIDVL 539
Q+ ++H ++E + + ++AL I E + + M I E K+
Sbjct: 446 VQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDT 505
Query: 540 SQQYMDLENEFRIALTVEA---RRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLI 596
+ Q L+ E + L + R+ +D+ + ++ +++ + + K NE+ +
Sbjct: 506 NSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSL 565
Query: 597 KDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLI 656
V++ K ++ S+ ++E + ++ + I++E+L+ EK ++
Sbjct: 566 S----TVEDLKAEIVSASESRKELELKHEAEVTNYK----------IKLEMLEKEKNAVL 611
Query: 657 SELA-AKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESD 715
+A ++E+ + LRT+ ++ HE + KL+ +E R N + K D
Sbjct: 612 DRMAESQEAELERLRTQ-LLFSHE---------EELSKLKEDLEIEHRIN--IEKL--KD 657
Query: 716 SDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEV 775
+ + K +I Q E +K++ EKD I + + I EI K Q +S+ +E+
Sbjct: 658 NLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEM 717
Query: 776 LEKLERHNERKEKLKQQLKGK---EVELEEIRKAYSTLNR----KWHDKGELLCHLETQV 828
++ + E L+Q+ K K E E++E++ L + K +D E LE +
Sbjct: 718 TLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAEN 777
Query: 829 KEVKEKFENKEKKLKAERDKSIELQKNAME--KLHSMDDAFKRQVDAIVEAHQ---AEIA 883
+K++ + E LK S E + ++ K S D ++++++ ++E ++ +
Sbjct: 778 SILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCI 837
Query: 884 QLANEKQKCIDSANLKVHQIEKEMRELLE------------ETCKNKKTMEAKIKQLAFA 931
QL E +K ++ + E +EL E E KNK+ +E K K A
Sbjct: 838 QLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSK--LKA 895
Query: 932 LNE 934
LNE
Sbjct: 896 LNE 898
Score = 88.2 bits (217), Expect = 3e-17
Identities = 149/718 (20%), Positives = 306/718 (42%), Gaps = 142/718 (19%)
Query: 320 VDQSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTT 379
+D+ H D +Q +++L+Q+ + R + +++L H EK D S LL+
Sbjct: 2074 IDREHERD-VFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSK 2132
Query: 380 DRLKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKD--QQEDHLKHLRTLEKTLEK 437
++L+ I +ERN + + KL+ +++L L+ + D Q+ + KH +E K
Sbjct: 2133 EQLQRDI-QERNEE------IEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA---K 2182
Query: 438 MERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRK 497
E Q A+ I E + + + ++ R L + E+ QQLH L ++++E
Sbjct: 2183 PELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT 2242
Query: 498 ELETRE-----FFTDADFQDALAKE---IAKEEK-----KHEQMIKEYQEKIDVLSQQYM 544
L+ E F D + KE ++ +++ K Q+I+E + +ID L++Q
Sbjct: 2243 RLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVT 2302
Query: 545 DLENEFRIALTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVK 604
L+ + +I ++ + K+ LI + E + L+ D C+ +
Sbjct: 2303 KLQQQLKITTD-----------------NKVIEEKNELI--RDLETQIECLMSDQECVKR 2343
Query: 605 EQKTKLAE----VSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISEL- 659
++ ++ + + KL+QE A Q L E+ Q++++ EK+ L ++
Sbjct: 2344 NREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVE 2403
Query: 660 AAKESLIF--GLRTERKVWGHELAQQGSSLAQNRGKLE-----------AQIESLSR--- 703
A E + F + E ++L Q+ SL + R +E I+ LS+
Sbjct: 2404 TANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP 2463
Query: 704 --------------ENECLRKTNESDSDA--LRIKCKIID----------DQTETIRKLK 737
EN+ K+ E + + ++ +++ + T+ +++K
Sbjct: 2464 ELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIK 2523
Query: 738 DCLQEKDEHIKRLQEKITEIEKCTQEQLDE---KSSQLDEVLE-------------KLER 781
D ++ + LQ+KI ++K +E++ QL+ V E + ER
Sbjct: 2524 DMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPER 2583
Query: 782 HN-ERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEK 840
N + +L++ G ++ +R S L + + L + QV+ ++ KEK
Sbjct: 2584 TNIQNLNQLREDELGSDISALTLR--ISELESQVVEMHTSLILEKEQVEIAEKNVLEKEK 2641
Query: 841 KL-----------KAERDK-------SIELQKNAMEKLHSMDDA-FKRQVDAIVEAHQAE 881
KL K +R+K +E+ K E HS +++ F +++A+ A
Sbjct: 2642 KLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVAT 2701
Query: 882 IAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNEIQQDM 939
A+LA+ K+ K ++++E+ L++ET N +++ + Q+ L E ++ +
Sbjct: 2702 KAELASYKE--------KAEKLQEEL--LVKET--NMTSLQKDLSQVRDHLAEAKEKL 2747
Score = 82.8 bits (203), Expect = 1e-15
Identities = 153/709 (21%), Positives = 301/709 (42%), Gaps = 108/709 (15%)
Query: 307 LQESEKPKTEIIKVDQSHSEDNT-----YQSLVEQLDQEREKRWRA----EQAENKLMDY 357
L+ ++ +TE+++ ++ T + L E+L +E R + +AE + Y
Sbjct: 1868 LEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGY 1927
Query: 358 IDE---LHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKLT--V 412
DE + EK DI DRL++ + N +LE ++Q E + L+
Sbjct: 1928 ADEKTLFERQIQEKTDI-------IDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 413 ELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRT 472
E MKA+ + + L+ EK ++ E+ + Q QA ++R + ++KA D E + R
Sbjct: 1981 EAMKAEAGPVEQ-QLLQETEKLMK--EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRF 2037
Query: 473 SLHREREQAQQLHQLLALKEQEHRKELETREFFTDADF------QDALAKEIAKEE---- 522
+ E+E+ +L L + Q K+LE F D +D +EI K E
Sbjct: 2038 -IELEQEKNTELMDLRQ-QNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
Query: 523 -------------KKHEQMIKEYQEKIDVLSQQYMDLEN---------------EFRI-- 552
++ EQ+ +EK D S+ + E EFR+
Sbjct: 2096 VVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
Query: 553 ---ALTVEARRFQDVKDGFENVATELAKSKHALIWAQ-------RKENESSSLIKDLTCM 602
AL V A FQ V+D A E + Q RKE E ++L + L
Sbjct: 2156 LEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQF 2215
Query: 603 VKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAK 662
+E + K EV +L + + L+ L +++K L K + +L LA K
Sbjct: 2216 REELENKNEEVQQLHMQLEIQKKESTTRLQELEQENK-------LFKDDMEKL--GLAIK 2266
Query: 663 ESLIFGLRTERKVWG------HELAQQGSSLAQNRGKLEAQIESLSRENECLRKTNESDS 716
ES + + ++G E + L + KL+ Q++ ++ +N+ + + NE
Sbjct: 2267 ESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLK-ITTDNKVIEEKNELIR 2325
Query: 717 DA-LRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEV 775
D +I+C ++ DQ R ++ +++ +E I++LQ+++ I + T S + D +
Sbjct: 2326 DLETQIEC-LMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSL 2384
Query: 776 LEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCHLETQ---VKEVK 832
+L+ K L+QQ++ E+ ++ N K + + L L+ + V++++
Sbjct: 2385 KHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQ 2444
Query: 833 EKFENK-----EKKLKAERDKSIELQKNAMEKLHSMD--DAFKRQVDAIVEAHQAEIAQL 885
EN + K + + + L ++A++ L + +F+ + + + QL
Sbjct: 2445 SIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQL 2504
Query: 886 ANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAKIKQLAFALNE 934
+ + + +L++ Q K+++++ E+ + ++ KI L + E
Sbjct: 2505 ----ESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEE 2549
Score = 73.6 bits (179), Expect = 8e-13
Identities = 158/774 (20%), Positives = 310/774 (40%), Gaps = 100/774 (12%)
Query: 117 TEINSSQLQCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAV 176
T+I + + LE L D L ++D L +++I+ + I EL +Q S+ +
Sbjct: 336 TKIIEEEKKTLE-LKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEI 394
Query: 177 LTSFMSVCQSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDT 236
+V E +K NH++ +Q+++ + + L + +D +
Sbjct: 395 KQLMGTV---EELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM----------- 440
Query: 237 DITSESDYGNR-KECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVS-CNRKMKPPYLKE 294
YG + + +++ R+ + +H + N+ S N + +K
Sbjct: 441 -------YGQQIVQMKQELIRQHMAQMEE---MKTRHKGEMENALRSYSNITVNEDQIKL 490
Query: 295 LYVSSSLANCPMLQ---ESEKPKTEI-IKVDQSHSEDNTYQSLVEQLDQEREKRWRAEQA 350
+ V+ + N + + EK K E+ + +++ + + LVE+L RE+ RA Q
Sbjct: 491 MNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQT 550
Query: 351 ENKLMDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEI--K 408
+ ++E HK + ED+ + + ++ KE+ K + EV +K++ E+ K
Sbjct: 551 IAEQESKLNEAHKSLSTVEDLKAEIVSASESRKEL-----ELKHEAEVTNYKIKLEMLEK 605
Query: 409 KLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIY 468
+ L + + QE L+ LRT Q+ E EL D EI
Sbjct: 606 EKNAVLDRMAESQEAELERLRT------------------QLLFSHEEELSKLKEDLEIE 647
Query: 469 LLRTSLHREREQA-----QQLHQLLALKEQEHRKELETREFFTD--ADFQDALAKEIAKE 521
R ++ + ++ QQ+ L + E +++ET +F D Q+ L EI+K
Sbjct: 648 H-RINIEKLKDNLGIHYKQQIDGL----QNEMSQKIETMQFEKDNLITKQNQLILEISKL 702
Query: 522 EKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGFENVATELAKSKHA 581
+ + ++ E++ + Q +L+ E I R+ + K E EL + K
Sbjct: 703 KDLQQSLVNSKSEEMTL---QINELQKEIEIL-----RQEEKEKGTLEQEVQEL-QLKTE 753
Query: 582 LIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQK 641
L+ Q KE E+ K E + + + K E + ++ E LI D K
Sbjct: 754 LLEKQMKEKENDLQEKFAQL---EAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK 810
Query: 642 SIQIELLKHEKVQLISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQIESL 701
S + + ++++++ E L+ + E+ +Q ++ + E + L
Sbjct: 811 SKSKDSVWEKEIEILIEENED------LKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
Query: 702 SRENECLRKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCT 761
E CL K + D+ + E KLK +E H++R+ +++
Sbjct: 865 QEEYACLLKVKDDLEDSKN------KQELEYKSKLKALNEEL--HLQRINPTTVKMKSSV 916
Query: 762 QEQLDEKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELL 821
DE + + E LE E + +L ++L+ + E E+ + S L+ + K +
Sbjct: 917 ---FDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEI 973
Query: 822 CHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMDDAFKRQVDAIV 875
L +EVK + KE+ R+ I + N E + S D +D +V
Sbjct: 974 SFLN---EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVV 1024
Score = 61.2 bits (147), Expect = 4e-09
Identities = 97/451 (21%), Positives = 200/451 (44%), Gaps = 87/451 (19%)
Query: 429 RTLEKTLEKMERQKRQQQAAQIRLIQEVE-LKASAADREIYLLRTSLHREREQAQQLHQL 487
R E+ +E + Q+A + L+ E++ L A R+I +L RE+E + +L
Sbjct: 3067 RIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKI-----TLKREQESEKPSQEL 3121
Query: 488 LALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLE 547
L Q+ K+ + E + A E+ ++ + ++ E + + L+Q ++LE
Sbjct: 3122 LEYNIQQ--KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSE---LAQTKLELE 3176
Query: 548 NEFRIA----LTVEARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMV 603
+ +EA R + VKD + V H L E + S ++L +
Sbjct: 3177 TTLKAQHKHLKELEAFRLE-VKDKTDEV--------HLLNDTLASEQKKS---RELQWAL 3224
Query: 604 KEQKTKLAEVSKLKQETAANLQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKE 663
+++K KL + +E ++ L+ +E KQ+++Q+ LL ++ QL++E K
Sbjct: 3225 EKEKAKLGRSEERDKE-------ELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQK- 3276
Query: 664 SLIFGLRTERKVWGHELA-QQGSS------LAQNRGKLEAQIESLSRENECLRKTNESDS 716
+ ++R ++ +L+ +QG + L + ++ +L RE E + SD
Sbjct: 3277 -----IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG 3331
Query: 717 DALRIKCKIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVL 776
Q+ +D L+E Q+QL+EK S++ E+L
Sbjct: 3332 TG----------QSRPPLPSEDLLKE------------------LQKQLEEKHSRIVELL 3363
Query: 777 EKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELLCH-LETQVKEVKEKF 835
+ E++ + +QQ+ E + + RK T ++ + +G+ H L+++V++++ +
Sbjct: 3364 NETEKYKLDSLQTRQQM---EKDRQVHRKTLQT-EQEANTEGQKKMHELQSKVEDLQRQL 3419
Query: 836 ENKEKK-----LKAERDKSI--ELQKNAMEK 859
E K ++ L+ +R + I E QK +E+
Sbjct: 3420 EEKRQQVYKLDLEGQRLQGIMQEFQKQELER 3450
Score = 60.1 bits (144), Expect = 1e-08
Identities = 131/676 (19%), Positives = 271/676 (40%), Gaps = 95/676 (14%)
Query: 268 QTIKHHNKNYNSFVSCNRKM-KPPYLKELYVSSSLANCPML-----QESEKPKTEIIKVD 321
Q I+ Y + + C +K + L E+ + N + QESEKP E++
Sbjct: 3066 QRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELL--- 3122
Query: 322 QSHSEDNTYQSLVEQLDQEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDR 381
E N Q + L+ + E + + D EL +E + S ++ +
Sbjct: 3123 ----EYNIQQKQSQMLEMQVEL--------SSMKDRATEL------QEQLSSEKMVVAEL 3164
Query: 382 LKEIIFRERNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQ 441
E+ +K +LE + +K+L ++ KD+ ++ + L TL +++
Sbjct: 3165 KSEL----AQTKLELETTLKAQHKHLKELEAFRLEVKDKTDE----VHLLNDTLASEQKK 3216
Query: 442 KRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQ---EHRKE 498
R+ Q A + ++ E+ L+ SL ++++ QL+ LL ++Q E +++
Sbjct: 3217 SRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQK 3276
Query: 499 LETREFFTDADFQDALAKEIAKEE--KKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTV 556
+E++ DA + + + + + + I+E +D + + L++ T
Sbjct: 3277 IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDG---TG 3333
Query: 557 EARRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKL 616
++R +D + + +L + KH+ I E E L L + +K + L
Sbjct: 3334 QSRPPLPSEDLLKELQKQL-EEKHSRIVELLNETEKYKL-DSLQTRQQMEKDRQVHRKTL 3391
Query: 617 KQETAAN---------LQNQINTLEILIEDDKQKSIQIELLKHEKVQLISELAAKESLIF 667
+ E AN LQ+++ L+ +E+ +Q+ +++L ++ E +E
Sbjct: 3392 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451
Query: 668 GLRTERKVWGHELAQQGS-SLAQNRGK---LEAQIESLSRENECLRKTNESDSDALRIKC 723
R R++ L + + SL +R + L+ +IE ++E+ + + C
Sbjct: 3452 EKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGT---GC 3508
Query: 724 KIIDDQTETIRKLKDCLQEKDEHIKRLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHN 783
+ + E IR+ C+ K + + + + + E E +DE++ +L
Sbjct: 3509 ---NHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQL---- 3561
Query: 784 ERKEKLKQQLKGKEVELEEIRKAYSTL-NRKWHDKGELLCHLETQVKEVKEKFENKEKKL 842
+KL Q +G+E L + +L R EL H+ +Q+ E K N KL
Sbjct: 3562 ---QKLTGQ-QGEEPSLVSPSTSCGSLTERLLRQNAELTGHI-SQLTEEKNDLRNMVMKL 3616
Query: 843 K----------AERDKSIELQKNAMEKLHSMDDAFKRQVDAIVEAHQAEIAQLANEKQKC 892
+ A RD S N ++AI+ + + + QK
Sbjct: 3617 EEQIRWYRQTGAGRDNSSRFSLNG-----------GANIEAIIASEKEVWNREKLTLQKS 3665
Query: 893 IDSANLKVHQIEKEMR 908
+ A +V++++ E+R
Sbjct: 3666 LKRAEAEVYKLKAELR 3681
Score = 59.7 bits (143), Expect = 1e-08
Identities = 139/649 (21%), Positives = 267/649 (41%), Gaps = 98/649 (15%)
Query: 335 EQLDQEREKRWRAEQAENKLMDYIDELHKHA-----NEKEDIHSLALLTTDRLKEIIFRE 389
E+ +E+EK+ R+ Q L + H + NE E + + ++ T L ++E
Sbjct: 2654 EKKQREKEKK-RSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELAS--YKE 2710
Query: 390 RNSKGQLEVMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQ 449
+ K Q E++V + L K Q DHL + LEK E + Q++ +
Sbjct: 2711 KAEKLQEELLVKETN------MTSLQKDLSQVRDHLAEAKEKLSILEK-EDETEVQESKK 2763
Query: 450 IRLIQE--VELKASAADREIYLLRTSLHREREQAQQLHQLLALKEQEHRKELETREF--- 504
+ + ++L S A + L+ S + Q + + + Q E E
Sbjct: 2764 ACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQ 2823
Query: 505 FTDA--DFQDALAKEIAKEEKKH----EQMIKEYQEKIDVLSQQYMDLENEFRIALTVEA 558
FT+ Q+ A EI E +H E + +E+ + +L ++ L+ + + E
Sbjct: 2824 FTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEG 2883
Query: 559 RRFQDVKDGFENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQ 618
++ E+ S W Q S D+ + ++++ A S K+
Sbjct: 2884 SSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGF-DIASEGRGEESESATDSFPKK 2942
Query: 619 -----ETAANLQNQINTL-EILIEDDKQKSIQ--IELLKHEKVQLISELAAKESLIFGLR 670
N Q+ +L E D + SIQ E E+ I+ +++ + LI ++
Sbjct: 2943 IKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQ 3002
Query: 671 TERKVWGHELAQQGSSLAQNRGKLEAQIESLSRENECL-------RKTNESDSDALRI-K 722
+R+ ++ +Q S + RG+L ++ + E + T +DA+ +
Sbjct: 3003 LQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLN 3062
Query: 723 C--KIIDDQTETIRKLKDCLQEKDE----------HIKRLQEKIT-----EIEKCTQEQL 765
C + I +Q + +CLQ+ D H + KIT E EK +QE L
Sbjct: 3063 CLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELL 3122
Query: 766 D----EKSSQLDEVLEKLERHNERKEKLKQQLKGKEVELEEIRKAYSTLNRKWHDKGELL 821
+ +K SQ+ E+ +L +R +L++QL +++ + E++ + K EL
Sbjct: 3123 EYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELA------QTKLELE 3176
Query: 822 CHLETQVKEVKE----KFENKEK---------KLKAERDKSIELQ---KNAMEKLHSMDD 865
L+ Q K +KE + E K+K L +E+ KS ELQ + KL ++
Sbjct: 3177 TTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE 3236
Query: 866 AFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEET 914
K +++ + L ++KQ+ NL+++ + ++ ++LL E+
Sbjct: 3237 RDKEELEDLK-------FSLESQKQR-----NLQLNLLLEQQKQLLNES 3273
Score = 42.4 bits (98), Expect = 0.002
Identities = 144/750 (19%), Positives = 293/750 (39%), Gaps = 134/750 (17%)
Query: 125 QCLEGLLDNLVSSDSPLNISEDEIIDRMPVITAPIDELVPLEQFASTPSDAVLTSFMSVC 184
Q ++GL + + + +D +I + + I +L L+Q S+
Sbjct: 665 QQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQ--------------SLV 710
Query: 185 QSSEPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSIDNVLEKDPRPKRDTDITSESDY 244
S E N+LQ EI++ + +++ L + + E + ++ + + +
Sbjct: 711 NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKF 770
Query: 245 GNRKECNRKVPRRSKIPYDAKTIQTIKHHNKNYNSFVSCNRKMKPP-YLKELYVSSSLAN 303
+ N + K D I T + S K K + KE+ +
Sbjct: 771 AQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI------ 824
Query: 304 CPMLQESEKPKTEIIKVDQ---------SHSEDN---TYQSLVEQLDQEREKRWRAEQAE 351
+++E+E K + I++++ S +E N YQ L E+ + + E ++
Sbjct: 825 --LIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSK 882
Query: 352 NKL-MDYIDELHKHANEKEDIHSLALLTTDRLKEIIFRERNSKGQLEVMVHKLQNEIKKL 410
NK ++Y +L K NE+ + + TT ++K +F E + ++ ++K
Sbjct: 883 NKQELEYKSKL-KALNEELHLQRINP-TTVKMKSSVFDEDKT---FVAETLEMGEVVEKD 937
Query: 411 TVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQA---AQIRLIQEVELKASAADREI 467
T ELM+ + + L L + +QK + + +++ +++ + + S RE+
Sbjct: 938 TTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCREL 997
Query: 468 YLLRTSLHREREQA--QQLHQLL------ALKEQEHRKELETREFFTDADF--QDALAKE 517
++ E Q+ Q+ LL + E + F ++ +D ++ E
Sbjct: 998 EIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFE 1057
Query: 518 --IAKEEKKHEQMIKEY---------------------QEKIDVLSQQYMDLENEF---R 551
EE K EQ+I ++ Q++++VL + DL + R
Sbjct: 1058 NMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQR 1117
Query: 552 IALT-VEARRFQDVKDGFENVATE-LAKSKHALIWAQR-----------------KENES 592
I L+ V + V++ EN + L K LI+AQ K E+
Sbjct: 1118 ICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQET 1177
Query: 593 SSLIKDLTCMVKEQKTKLAEVSKLKQETAANLQNQINTLEILIE---DDKQKS------- 642
K L ++ + + ++E +T ++ + T + E +DK+ S
Sbjct: 1178 GDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISEN 1237
Query: 643 ---------IQIELLKHEKVQLISELAAKESLIFGLRTE-RKVWGHELAQQGSSLAQNRG 692
+++ + L++++ + + + L+T K+WG QQ +
Sbjct: 1238 EDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWG----QQTDGM----- 1288
Query: 693 KLEAQIESLSREN-ECL----RKTNESDSDALRIKCKIIDDQTETIRKLKDCLQEKDEHI 747
KLE E+L +E E L + TN D D + K K+ Q KL++ +QE + I
Sbjct: 1289 KLEFGEENLPKEETEFLSIHSQMTNLEDID-VNHKSKLSSLQDLEKTKLEEQVQELESLI 1347
Query: 748 KRLQEKITEIEKCTQEQLDEKSSQLDEVLE 777
LQ+++ E E+ + ++ +L V E
Sbjct: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSE 1377
Score = 38.5 bits (88), Expect = 0.030
Identities = 96/553 (17%), Positives = 211/553 (38%), Gaps = 74/553 (13%)
Query: 425 LKHLRTLEKTLEKMERQKRQQQAAQIRLIQEVELKASAADREIYLLRTSLHREREQAQQL 484
+K + K LEK +++ +++ A++ + + A ++ L R S +E + +
Sbjct: 1422 VKEETNIVKLLEKQYQEQLEEEVAKVIVSMSI-----AFAQQTELSRISGGKENTASSKQ 1476
Query: 485 HQLLALKEQEHRKELETREFFTDADFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYM 544
+ +EQ + E++ + + + + +E K + + E+ ++I + +
Sbjct: 1477 AHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPH 1536
Query: 545 DLENEFRIALTVEARRF---------QDVKDGFENVATELAKSKHALIWAQRKENESSSL 595
D+ LT+ F Q + D E + + S+ ++ ++ E+ L
Sbjct: 1537 DIPESKDCVLTISEEMFSKDKTFIVRQSIHD--EISVSSMDASRQLMLNEEQLEDMRQEL 1594
Query: 596 IKDLTCMVKEQKTKLAEVSKLKQ-----ETAANLQNQINTLEILIEDDKQKSIQIELLKH 650
++ +Q T+L + ++Q E LQ +I L + ++ SI E L
Sbjct: 1595 VRQY--QEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLA--QRSSIDNENLVS 1650
Query: 651 EKVQ-LISELAAKESLIFGLRTERKVWGHELAQQGSSLAQNRGKLEAQI----------- 698
E+ + L+ EL A + L R + + Q + +N+G++E Q
Sbjct: 1651 ERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPE 1710
Query: 699 ----ESLSRENECLRKTNESDSDALRIKCKIIDDQTETIRKL------KDCLQEKDEHIK 748
E LS E L+K N L K ETI + + + +
Sbjct: 1711 DVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLI 1770
Query: 749 RLQEKITEIEKCTQEQLDEKSSQLDEVLEKLERHNERKEKLKQQLK----GKEVELEEIR 804
E ++ C E E + DE + + + + K G E+ +R
Sbjct: 1771 WRSEAEASVKSCVHE---EHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVR 1827
Query: 805 KAYSTLNRKWHDKGELLCHLETQVKEVKEKFENKEKKLKAERDKSIELQKNAMEKLHSMD 864
++ ++ EL+ ++ ++++ EK L+A + S +L+ + + M
Sbjct: 1828 SGFAGTEIDPENE-ELMLNISSRLQAAVEKL------LEAISETSSQLEHAKVTQTELMR 1880
Query: 865 DAFKRQVDAIVEAHQAEIAQLANEKQKCIDSANLKVHQIEKEMRELLEETCKNKKTMEAK 924
++F+++ Q A E KC + ++H+ + +L E K + ++
Sbjct: 1881 ESFRQK-------------QEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGY 1927
Query: 925 IKQLAFALNEIQQ 937
+ +IQ+
Sbjct: 1928 ADEKTLFERQIQE 1940
Score = 33.1 bits (74), Expect = 1.2
Identities = 89/471 (18%), Positives = 174/471 (36%), Gaps = 73/471 (15%)
Query: 188 EPEKNNHENDLQNEIKLQKLDDQILQLLNETSNSI-------DNVLEKDPRPKRDTDITS 240
E K + E+ Q ++L L +Q QLLNE+ I D L ++ + +
Sbjct: 3243 EDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLL 3302
Query: 241 ESDYGNRKECNRKVPR-----------------RSKIPYDAKTIQTIKHHNKNYNSFVSC 283
ES+ +E + + R R +P + + K + ++ V
Sbjct: 3303 ESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVEL 3362
Query: 284 NRKMKPPYLKELYVSSSL-----ANCPMLQESEKPKTEIIKVDQSHSEDNTYQSLVEQLD 338
+ + L L + + LQ ++ TE K + H + + L QL+
Sbjct: 3363 LNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQK--KMHELQSKVEDLQRQLE 3420
Query: 339 QEREKRWRAEQAENKLMDYIDELHKHANEKEDIHSLALLTTDRLKE-IIFRERNSKGQLE 397
++R++ ++ + +L + E K E+E+ + L E + + + +
Sbjct: 3421 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNW 3480
Query: 398 VMVHKLQNEIKKLTVELMKAKDQQEDHLKHLRTLEKTLEKMERQKRQQQAAQIRLIQE-- 455
V+ K++ E K+ + + H LE M RQK Q A++++++ +
Sbjct: 3481 VLQQKIEGETKESNYAKLIEMNGGGTGCNH--ELE-----MIRQKLQCVASKLQVLPQKA 3533
Query: 456 -VELKASAADREIYLL------RTSLHREREQAQQLHQLLALKEQEHRKELETREFFTDA 508
L+ AD E ++ L ++ QQ + + L R +A
Sbjct: 3534 SERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNA 3593
Query: 509 DFQDALAKEIAKEEKKHEQMIKEYQEKIDVLSQQYMDLENEFRIALTVEARRFQDVKDGF 568
+ ++ ++ +E+ M+ + +E+I Q +N R +L +G
Sbjct: 3594 ELTGHIS-QLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSL-----------NGG 3641
Query: 569 ENVATELAKSKHALIWAQRKENESSSLIKDLTCMVKEQKTKLAEVSKLKQE 619
N+ +A K +W + K SL K AEV KLK E
Sbjct: 3642 ANIEAIIASEKE--VWNREKLTLQKSL-----------KRAEAEVYKLKAE 3679
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,566,717
Number of Sequences: 37866
Number of extensions: 1500183
Number of successful extensions: 20451
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 402
Number of HSP's successfully gapped in prelim test: 1246
Number of HSP's that attempted gapping in prelim test: 7992
Number of HSP's gapped (non-prelim): 6185
length of query: 939
length of database: 18,247,518
effective HSP length: 112
effective length of query: 827
effective length of database: 14,006,526
effective search space: 11583397002
effective search space used: 11583397002
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.