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Search of human proteins with 239744413
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo
sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo sap... 890 0.0
gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens] 455 e-128
gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens] 455 e-128
gi|6005997 double C2-like domains, beta [Homo sapiens] 365 e-101
gi|47078261 double C2-like domains, alpha [Homo sapiens] 326 2e-89
gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens] 322 4e-88
gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens] 322 4e-88
gi|209447073 synaptotagmin I [Homo sapiens] 129 7e-30
gi|5032139 synaptotagmin I [Homo sapiens] 129 7e-30
gi|209447070 synaptotagmin I [Homo sapiens] 129 7e-30
gi|211059429 synaptotagmin II [Homo sapiens] 126 3e-29
gi|31543670 synaptotagmin II [Homo sapiens] 126 3e-29
gi|92859638 synaptotagmin V [Homo sapiens] 116 4e-26
gi|38570146 synaptotagmin VII [Homo sapiens] 115 1e-25
gi|24308219 synaptotagmin IV [Homo sapiens] 113 4e-25
gi|45504376 synaptotagmin VI [Homo sapiens] 111 1e-24
gi|39752671 synaptotagmin X [Homo sapiens] 110 3e-24
gi|94536846 synaptotagmin VIII [Homo sapiens] 108 7e-24
gi|28376627 synaptotagmin IX [Homo sapiens] 108 1e-23
gi|216548478 synaptotagmin XI [Homo sapiens] 100 2e-21
gi|40068038 B/K protein [Homo sapiens] 95 1e-19
gi|238550198 synaptotagmin III [Homo sapiens] 93 4e-19
gi|238550196 synaptotagmin III [Homo sapiens] 93 4e-19
gi|14150054 synaptotagmin III [Homo sapiens] 93 4e-19
gi|193804862 synaptotagmin-like 4 [Homo sapiens] 91 2e-18
gi|193804860 synaptotagmin-like 4 [Homo sapiens] 91 2e-18
gi|123173752 synaptotagmin XIV-like [Homo sapiens] 84 2e-16
gi|150170670 piccolo isoform 2 [Homo sapiens] 82 1e-15
gi|150378539 piccolo isoform 1 [Homo sapiens] 82 1e-15
gi|226342962 synaptotagmin XIV isoform 2 [Homo sapiens] 81 2e-15
>gi|239744413 PREDICTED: hypothetical protein LOC390213 [Homo
sapiens]
Length = 431
Score = 890 bits (2300), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MSAYPLPAAATHTGSLHGISDASSPHFRGRVRSRQPQSSGISLSLRPPPPVWVPMAGTAA 60
MSAYPLPAAATHTGSLHGISDASSPHFRGRVRSRQPQSSGISLSLRPPPPVWVPMAGTAA
Sbjct: 1 MSAYPLPAAATHTGSLHGISDASSPHFRGRVRSRQPQSSGISLSLRPPPPVWVPMAGTAA 60
Query: 61 AGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAASAVRSA 120
AGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAASAVRSA
Sbjct: 61 AGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAASAVRSA 120
Query: 121 PQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKAN 180
PQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKAN
Sbjct: 121 PQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKAN 180
Query: 181 LLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMV 240
LLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMV
Sbjct: 181 LLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMV 240
Query: 241 QRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQ 300
QRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQ
Sbjct: 241 QRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQ 300
Query: 301 QGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFY 360
QGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFY
Sbjct: 301 QGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFY 360
Query: 361 SGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWH 420
SGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWH
Sbjct: 361 SGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWH 420
Query: 421 PLDSKPVQLSD 431
PLDSKPVQLSD
Sbjct: 421 PLDSKPVQLSD 431
>gi|169202933 PREDICTED: similar to hCG21066 [Homo sapiens]
Length = 451
Score = 455 bits (1171), Expect = e-128
Identities = 222/222 (100%), Positives = 222/222 (100%)
Query: 55 MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 114
MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA
Sbjct: 1 MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60
Query: 115 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 174
SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD
Sbjct: 61 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120
Query: 175 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 234
AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC
Sbjct: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180
Query: 235 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL 276
VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL
Sbjct: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL 222
Score = 329 bits (844), Expect = 3e-90
Identities = 155/158 (98%), Positives = 157/158 (99%)
Query: 274 RRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 333
R +EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP
Sbjct: 294 RSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 353
Query: 334 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 393
NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL
Sbjct: 354 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
Query: 394 GSHASGERLRHWLECLGHSDHRLKLWHPLDSKPVQLSD 431
GSHASGERLRHWLECLGHSDHRL+LWHPLDSKPVQLSD
Sbjct: 414 GSHASGERLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
Score = 35.4 bits (80), Expect = 0.10
Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 12/114 (10%)
Query: 121 PQLQPDPEPEGDSDDSTA----------LGTLEFTLLFEADNSALHCTAHRAKGLKPL-A 169
P++ P+P+ +S S G + +L + + L R L P+ A
Sbjct: 280 PRVPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDA 339
Query: 170 SGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTL 223
+G +D +V+ L P A K S+ +T R T P + E Y G R++ KTL
Sbjct: 340 NGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTL 392
Score = 35.0 bits (79), Expect = 0.13
Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 289 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRK 348
G + +L + + L R L P+ A+G +D +V+ L P A K S+ +T R
Sbjct: 86 GTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVRG 144
Query: 349 TLNPEFNEEFFYSG-PREELAQKTL 372
T P + E Y G R++ KTL
Sbjct: 145 TRVPVWEETLTYHGFTRQDAECKTL 169
>gi|169203543 PREDICTED: similar to hCG21066 [Homo sapiens]
Length = 451
Score = 455 bits (1171), Expect = e-128
Identities = 222/222 (100%), Positives = 222/222 (100%)
Query: 55 MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 114
MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA
Sbjct: 1 MAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAEPALHPPNLRPAAA 60
Query: 115 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 174
SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD
Sbjct: 61 SAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSAD 120
Query: 175 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 234
AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC
Sbjct: 121 AYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVC 180
Query: 235 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL 276
VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL
Sbjct: 181 VRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRL 222
Score = 329 bits (844), Expect = 3e-90
Identities = 155/158 (98%), Positives = 157/158 (99%)
Query: 274 RRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 333
R +EEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP
Sbjct: 294 RSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP 353
Query: 334 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 393
NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL
Sbjct: 354 NAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 413
Query: 394 GSHASGERLRHWLECLGHSDHRLKLWHPLDSKPVQLSD 431
GSHASGERLRHWLECLGHSDHRL+LWHPLDSKPVQLSD
Sbjct: 414 GSHASGERLRHWLECLGHSDHRLELWHPLDSKPVQLSD 451
Score = 35.4 bits (80), Expect = 0.10
Identities = 31/114 (27%), Positives = 50/114 (43%), Gaps = 12/114 (10%)
Query: 121 PQLQPDPEPEGDSDDSTA----------LGTLEFTLLFEADNSALHCTAHRAKGLKPL-A 169
P++ P+P+ +S S G + +L + + L R L P+ A
Sbjct: 280 PRVPSAPDPKHNSARSMEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDA 339
Query: 170 SGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTL 223
+G +D +V+ L P A K S+ +T R T P + E Y G R++ KTL
Sbjct: 340 NGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSG-PREELAQKTL 392
Score = 35.0 bits (79), Expect = 0.13
Identities = 26/85 (30%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 289 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRK 348
G + +L + + L R L P+ A+G +D +V+ L P A K S+ +T R
Sbjct: 86 GTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVRG 144
Query: 349 TLNPEFNEEFFYSG-PREELAQKTL 372
T P + E Y G R++ KTL
Sbjct: 145 TRVPVWEETLTYHGFTRQDAECKTL 169
>gi|6005997 double C2-like domains, beta [Homo sapiens]
Length = 412
Score = 365 bits (937), Expect = e-101
Identities = 203/408 (49%), Positives = 262/408 (64%), Gaps = 55/408 (13%)
Query: 63 GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHF----YPFAEP-ALHPPN--LRPAAAS 115
G+ +S+QEHMAIDV PGPIRPI+ IS YFP F P A P A PP+ RPA A
Sbjct: 7 GEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPDAGPRAAAPPDAPARPAVAG 66
Query: 116 AVRSAPQ----------------------------------LQPDPEPEGD---SDDSTA 138
A R +P P+ EP+ D SDD TA
Sbjct: 67 AGRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDADGYESDDCTA 126
Query: 139 LGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQLRTHTVR 197
LGTL+F+LL++ +N+ALHCT +AKGLKP+ +G AD YVK +LLPGASKA++LRT T+R
Sbjct: 127 LGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLR 186
Query: 198 GTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLR 257
T P W ETLTY+G T +D KTLR +VC ++ +GE RVPL+
Sbjct: 187 NTLNPTWNETLTYYGITDEDMIRKTLRI------SVCDEDKFRHNEF----IGETRVPLK 236
Query: 258 KLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPM 317
KL PN ++F+ICLEK+ + + + EE G +L+SL YSSQ+ GLLVG++RCAHLA M
Sbjct: 237 KLKPNHTKTFNICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAM 296
Query: 318 DANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVW 377
DANGYSDP+V+ +L P+ KKSK KT+V +KTLNPEFNEEF Y +LA+K+L V+VW
Sbjct: 297 DANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKSLEVTVW 356
Query: 378 DYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWHPLDSK 425
DYD+G ++DFIGGV LG HA GERL+HW +CL + D R++ WH L S+
Sbjct: 357 DYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERWHTLTSE 404
>gi|47078261 double C2-like domains, alpha [Homo sapiens]
Length = 400
Score = 326 bits (836), Expect = 2e-89
Identities = 193/396 (48%), Positives = 243/396 (61%), Gaps = 45/396 (11%)
Query: 63 GQPPRVSMQEHMAIDVSPGPIRPIRLISHYFPHFYPFAE---------PA-LHPPNLRPA 112
G +++QEHMAI+V PGPIRPIR IS YFP P E PA L P L P
Sbjct: 6 GDRMTINIQEHMAINVCPGPIRPIRQISDYFPRG-PGPEGGGGGGGEAPAHLVPLALAPP 64
Query: 113 AASAVRSAPQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SG 171
AA + P+ + + DSDD+TALGTLEF LL++ + LHC+ RAKGLKP+ +G
Sbjct: 65 AALLGATTPEDGAEVDSY-DSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNG 123
Query: 172 SADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQ 231
AD YVK +LLPGA KA++L+T T R T PVW E LTY G T D K LR
Sbjct: 124 LADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRI------ 177
Query: 232 AVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEK------------------ 273
AVC + ++ +GE+RVPLR+L P++ + F+ICLE+
Sbjct: 178 AVCDEDKLSHNEF----IGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGIS 233
Query: 274 ---RRLEEVET-EVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRL 329
+ LE+ E + EE G +LLSL YSS++ GLLVG+LRCAHLA MD NGYSDP+V+
Sbjct: 234 CYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKT 293
Query: 330 FLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG 389
+L P+ KKSK KT V +KTLNPEFNEEFFY LA KTL V+VWDYD+G ++DFIG
Sbjct: 294 YLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIG 353
Query: 390 GVQLGSHASGERLRHWLECLGHSDHRLKLWHPLDSK 425
GV LG A GE +HW +CL D L+ WH L S+
Sbjct: 354 GVSLGPGARGEARKHWSDCLQQPDAALERWHTLTSE 389
>gi|219804203 rabphilin 3A homolog isoform 1 [Homo sapiens]
Length = 694
Score = 322 bits (825), Expect = 4e-88
Identities = 187/432 (43%), Positives = 253/432 (58%), Gaps = 41/432 (9%)
Query: 31 VRSRQPQSSGISLSLRPPPPVWVPMAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLIS 90
V++ +P + P P G+ G R Q+ PG P R
Sbjct: 273 VQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPGTTAPPREER 332
Query: 91 HYFPHFYPFA----EPALHP--PNLRPAAASAVRSAPQLQPDPEPEG------DSDDSTA 138
YP + HP P + +AA+ +A + P PE E DSD++T
Sbjct: 333 TGGVGGYPAVGAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATT 392
Query: 139 LGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKASQLRTHTVR 197
LG LEF+LL++ DNS+L CT +AKGLKP+ S G AD YVK +LLPGASK+++LRT T+R
Sbjct: 393 LGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLR 452
Query: 198 GTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLR 257
TR P+W ETL YHG T +D + KTLR +VC ++ +GE R L+
Sbjct: 453 NTRNPIWNETLVYHGITDEDMQRKTLRI------SVCDEDKFGHNEF----IGETRFSLK 502
Query: 258 KLVPNRARSFDICLEK------------------RRLEEVETEVAWEECGHVLLSLCYSS 299
KL PN+ ++F+ICLE+ E+VE EE G +L+SL YS+
Sbjct: 503 KLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSLMYST 562
Query: 300 QQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFF 359
QQGGL+VG++RC HLA MDANGYSDPFV+L+L P+ GKK+K KT + +KTLNPEFNEEFF
Sbjct: 563 QQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFF 622
Query: 360 YSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLW 419
Y +LA+K+L +SVWDYD+G ++D+IGG QLG A GERL+HW ECL + D +++ W
Sbjct: 623 YDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERW 682
Query: 420 HPLDSKPVQLSD 431
H L ++ SD
Sbjct: 683 HQLQNENHVSSD 694
>gi|45267837 rabphilin 3A homolog isoform 2 [Homo sapiens]
Length = 690
Score = 322 bits (825), Expect = 4e-88
Identities = 187/432 (43%), Positives = 253/432 (58%), Gaps = 41/432 (9%)
Query: 31 VRSRQPQSSGISLSLRPPPPVWVPMAGTAAAGGQPPRVSMQEHMAIDVSPGPIRPIRLIS 90
V++ +P + P P G+ G R Q+ PG P R
Sbjct: 269 VQASRPAPGSVQSPAPPQPGQPGTPGGSRPGPGPAGRFPDQKPEVAPSDPGTTAPPREER 328
Query: 91 HYFPHFYPFA----EPALHP--PNLRPAAASAVRSAPQLQPDPEPEG------DSDDSTA 138
YP + HP P + +AA+ +A + P PE E DSD++T
Sbjct: 329 TGGVGGYPAVGAREDRMSHPSGPYSQASAAAPQPAAARQPPPPEEEEEEANSYDSDEATT 388
Query: 139 LGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKASQLRTHTVR 197
LG LEF+LL++ DNS+L CT +AKGLKP+ S G AD YVK +LLPGASK+++LRT T+R
Sbjct: 389 LGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNGLADPYVKLHLLPGASKSNKLRTKTLR 448
Query: 198 GTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLR 257
TR P+W ETL YHG T +D + KTLR +VC ++ +GE R L+
Sbjct: 449 NTRNPIWNETLVYHGITDEDMQRKTLRI------SVCDEDKFGHNEF----IGETRFSLK 498
Query: 258 KLVPNRARSFDICLEK------------------RRLEEVETEVAWEECGHVLLSLCYSS 299
KL PN+ ++F+ICLE+ E+VE EE G +L+SL YS+
Sbjct: 499 KLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERVGDIEERGKILVSLMYST 558
Query: 300 QQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFF 359
QQGGL+VG++RC HLA MDANGYSDPFV+L+L P+ GKK+K KT + +KTLNPEFNEEFF
Sbjct: 559 QQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFF 618
Query: 360 YSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLW 419
Y +LA+K+L +SVWDYD+G ++D+IGG QLG A GERL+HW ECL + D +++ W
Sbjct: 619 YDIKHSDLAKKSLDISVWDYDIGKSNDYIGGCQLGISAKGERLKHWYECLKNKDKKIERW 678
Query: 420 HPLDSKPVQLSD 431
H L ++ SD
Sbjct: 679 HQLQNENHVSSD 690
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 129 bits (323), Expect = 7e-30
Identities = 94/298 (31%), Positives = 144/298 (48%), Gaps = 20/298 (6%)
Query: 126 DPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPG 184
D E + + + LG L+++L ++ N+ L +A L L G++D YVK LLP
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD 189
Query: 185 ASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQW 244
K + + H R T PV+ E T+ K S+LGG V R
Sbjct: 190 KKKKFETKVH--RKTLNPVFNEQFTF----------KVPYSELGGKTLVMAVYDF-DRFS 236
Query: 245 QAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGL 304
+ +GE +VP+ N + E R L+ E E E+ G + SL Y G L
Sbjct: 237 KHDIIGEFKVPM-----NTVDFGHVTEEWRDLQSAEKEEQ-EKLGDICFSLRYVPTAGKL 290
Query: 305 LVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPR 364
V +L +L MD G SDP+V++ L N + K KT++ + TLNP +NE F + P
Sbjct: 291 TVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPF 350
Query: 365 EELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWHPL 422
E++ + ++V+V DYD +D IG V +G +++G LRHW + L + + WH L
Sbjct: 351 EQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTL 408
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 129 bits (323), Expect = 7e-30
Identities = 94/298 (31%), Positives = 144/298 (48%), Gaps = 20/298 (6%)
Query: 126 DPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPG 184
D E + + + LG L+++L ++ N+ L +A L L G++D YVK LLP
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD 189
Query: 185 ASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQW 244
K + + H R T PV+ E T+ K S+LGG V R
Sbjct: 190 KKKKFETKVH--RKTLNPVFNEQFTF----------KVPYSELGGKTLVMAVYDF-DRFS 236
Query: 245 QAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGL 304
+ +GE +VP+ N + E R L+ E E E+ G + SL Y G L
Sbjct: 237 KHDIIGEFKVPM-----NTVDFGHVTEEWRDLQSAEKEEQ-EKLGDICFSLRYVPTAGKL 290
Query: 305 LVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPR 364
V +L +L MD G SDP+V++ L N + K KT++ + TLNP +NE F + P
Sbjct: 291 TVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPF 350
Query: 365 EELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWHPL 422
E++ + ++V+V DYD +D IG V +G +++G LRHW + L + + WH L
Sbjct: 351 EQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTL 408
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 129 bits (323), Expect = 7e-30
Identities = 94/298 (31%), Positives = 144/298 (48%), Gaps = 20/298 (6%)
Query: 126 DPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPG 184
D E + + + LG L+++L ++ N+ L +A L L G++D YVK LLP
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPD 189
Query: 185 ASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQW 244
K + + H R T PV+ E T+ K S+LGG V R
Sbjct: 190 KKKKFETKVH--RKTLNPVFNEQFTF----------KVPYSELGGKTLVMAVYDF-DRFS 236
Query: 245 QAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGL 304
+ +GE +VP+ N + E R L+ E E E+ G + SL Y G L
Sbjct: 237 KHDIIGEFKVPM-----NTVDFGHVTEEWRDLQSAEKEEQ-EKLGDICFSLRYVPTAGKL 290
Query: 305 LVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPR 364
V +L +L MD G SDP+V++ L N + K KT++ + TLNP +NE F + P
Sbjct: 291 TVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPF 350
Query: 365 EELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWHPL 422
E++ + ++V+V DYD +D IG V +G +++G LRHW + L + + WH L
Sbjct: 351 EQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTL 408
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 126 bits (317), Expect = 3e-29
Identities = 96/297 (32%), Positives = 146/297 (49%), Gaps = 21/297 (7%)
Query: 128 EPEGDSD-DSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGA 185
E EG+ + + LG L+F+L ++ + L +A L L G++D YVK LLP
Sbjct: 128 EGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDK 187
Query: 186 SKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQ 245
K + + H R T P + ET T+ K +LGG V R +
Sbjct: 188 KKKYETKVH--RKTLNPAFNETFTF----------KVPYQELGGKTLVMAIYDF-DRFSK 234
Query: 246 APSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLL 305
+GE++VP+ + + E R L+ E E E+ G + SL Y G L
Sbjct: 235 HDIIGEVKVPMNTVDLGQPIE-----EWRDLQGGEKEEP-EKLGDICTSLRYVPTAGKLT 288
Query: 306 VGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPRE 365
V +L +L MD G SDP+V++ L N + K KT+V +KTLNP FNE F + P E
Sbjct: 289 VCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFE 348
Query: 366 ELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWHPL 422
++ + ++V+V DYD ++ IG + +GS+A+G LRHW + L + + WH L
Sbjct: 349 QIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSL 405
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 126 bits (317), Expect = 3e-29
Identities = 96/297 (32%), Positives = 146/297 (49%), Gaps = 21/297 (7%)
Query: 128 EPEGDSD-DSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGA 185
E EG+ + + LG L+F+L ++ + L +A L L G++D YVK LLP
Sbjct: 128 EGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDK 187
Query: 186 SKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQ 245
K + + H R T P + ET T+ K +LGG V R +
Sbjct: 188 KKKYETKVH--RKTLNPAFNETFTF----------KVPYQELGGKTLVMAIYDF-DRFSK 234
Query: 246 APSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLL 305
+GE++VP+ + + E R L+ E E E+ G + SL Y G L
Sbjct: 235 HDIIGEVKVPMNTVDLGQPIE-----EWRDLQGGEKEEP-EKLGDICTSLRYVPTAGKLT 288
Query: 306 VGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPRE 365
V +L +L MD G SDP+V++ L N + K KT+V +KTLNP FNE F + P E
Sbjct: 289 VCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFE 348
Query: 366 ELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWHPL 422
++ + ++V+V DYD ++ IG + +GS+A+G LRHW + L + + WH L
Sbjct: 349 QIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSL 405
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 116 bits (290), Expect = 4e-26
Identities = 90/303 (29%), Positives = 141/303 (46%), Gaps = 21/303 (6%)
Query: 122 QLQPDPEPEGDS-DDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKA 179
+L+P P G D LG L+++L ++ + L +A GL L GS+D YV+
Sbjct: 91 ELEPAPSGPGQQVADKHELGRLQYSLDYDFQSGQLLVGILQAMGLAALDLGGSSDPYVRV 150
Query: 180 NLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPM 239
LLP + + + H R T P + ET + K +LGG V
Sbjct: 151 YLLPDKRRRYETKVH--RQTLNPHFGETFAF----------KVPYVELGGRVLVMAVYDF 198
Query: 240 VQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSS 299
R + ++GE+RVP+ + R ++ R + E+ G + SL Y
Sbjct: 199 -DRFSRNDAIGEVRVPMSSVDLGRP------VQAWRELQAAPREEQEKLGDICFSLRYVP 251
Query: 300 QQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFF 359
G L V VL +L MD G SDP+V++ L K K KT++ + TLNP +NE F
Sbjct: 252 TAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFS 311
Query: 360 YSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLW 419
+ P +++ + + ++V DYD ++ IG V +G+ A G LRHW + L + + W
Sbjct: 312 FEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADMLANPRRPIAQW 371
Query: 420 HPL 422
H L
Sbjct: 372 HSL 374
>gi|38570146 synaptotagmin VII [Homo sapiens]
Length = 403
Score = 115 bits (287), Expect = 1e-25
Identities = 82/304 (26%), Positives = 141/304 (46%), Gaps = 22/304 (7%)
Query: 120 APQLQPDPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSADAYVK 178
+P + D EG S ++ LG ++F++ + S L +A+ L SG++D +VK
Sbjct: 119 SPGSEEDEAHEGCSREN--LGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVK 176
Query: 179 ANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGP 238
LLP K +L T R P W ET + GF + + L + + P
Sbjct: 177 IYLLP--DKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDP 234
Query: 239 MVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYS 298
+GE+ +PL K+ + ++F L+ G +LLSLCY+
Sbjct: 235 ----------IGEVSIPLNKVDLTQMQTFWKDLKP-------CSDGSGSRGELLLSLCYN 277
Query: 299 SQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEF 358
++V +++ +L MD G SDP+V+++L + K KT ++ LNP FNE F
Sbjct: 278 PSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESF 337
Query: 359 FYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKL 418
+ P E+L + T++++V D D + +D IG + L + ++HW + + +
Sbjct: 338 AFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQ 397
Query: 419 WHPL 422
WH L
Sbjct: 398 WHQL 401
>gi|24308219 synaptotagmin IV [Homo sapiens]
Length = 425
Score = 113 bits (282), Expect = 4e-25
Identities = 97/338 (28%), Positives = 155/338 (45%), Gaps = 47/338 (13%)
Query: 108 NLRPAAASAVRSA-PQLQPDPEPEGDSDDSTA-------------LGTLEFTLLFEADNS 153
NL+P + S + +A P+L + E E S +S LGTL F+L + +
Sbjct: 109 NLKPGSPSDLENATPKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERK 168
Query: 154 ALHCTAHRAKGLKPL--ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYH 211
A A+GL + S ++D Y+K +LP K +++T +R T P ++ET T++
Sbjct: 169 AFVVNIKEARGLPAMDEQSMTSDPYIKMTILP--EKKHKVKTRVLRKTLDPAFDETFTFY 226
Query: 212 GFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLR-------KLVPNRA 264
G + +L H + R + +GE+ +PL K++ NR
Sbjct: 227 GIPYTQIQ------ELALHFTIL----SFDRFSRDDIIGEVLIPLSGIELSEGKMLMNRE 276
Query: 265 RSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSD 324
+ KR + + G +L+SLCY S L V VL+ HL D +G SD
Sbjct: 277 ------IIKRNVRKSSGR------GELLISLCYQSTTNTLTVVVLKARHLPKSDVSGLSD 324
Query: 325 PFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTA 384
P+V++ L+ + SK KT V + T N FNE F + P E L ++ V D + G+
Sbjct: 325 PYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCEGLEDISVEFLVLDSERGSR 384
Query: 385 DDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWHPL 422
++ IG + LG+ A G HW E + ++ WH L
Sbjct: 385 NEVIGQLVLGAAAEGTGGEHWKEICDYPRRQIAKWHVL 422
>gi|45504376 synaptotagmin VI [Homo sapiens]
Length = 425
Score = 111 bits (277), Expect = 1e-24
Identities = 91/322 (28%), Positives = 147/322 (45%), Gaps = 27/322 (8%)
Query: 109 LRPAA---ASAVRSAPQLQPDPEPEGD---SDDSTALGTLEFTLLFEADNSALHCTAHRA 162
L PAA S R P+L +G+ S+ + + G + F+L ++ + L +A
Sbjct: 109 LPPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYDYETETLIVRILKA 168
Query: 163 KGLKPLA-SGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECK 221
L GS+D YVK LLP Q R H R T P ++E + + A+ K
Sbjct: 169 FDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVH--RKTLNPTFDENFHFPVPYEELADRK 226
Query: 222 TLRSDLGGHQAVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVET 281
S R + +GE+ ++ N + D+ E ++++
Sbjct: 227 LHLSVFD-----------FDRFSRHDMIGEV------ILDNLFEASDLSRETSIWKDIQY 269
Query: 282 EVAWE-ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSK 340
+ + G ++ SLCY G L + V++C +L MD GYSDP+V++ L + + K
Sbjct: 270 ATSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKK 329
Query: 341 FKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGE 400
KT++ + TLNP +NE + P E + Q +LL+SV DYD ++ IG ++G A G
Sbjct: 330 KKTTIKKNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGL 389
Query: 401 RLRHWLECLGHSDHRLKLWHPL 422
HW E L + + WH L
Sbjct: 390 GRDHWNEMLAYPRKPIAHWHSL 411
>gi|39752671 synaptotagmin X [Homo sapiens]
Length = 523
Score = 110 bits (274), Expect = 3e-24
Identities = 90/314 (28%), Positives = 143/314 (45%), Gaps = 24/314 (7%)
Query: 118 RSAPQL--QPDPEPEGDSDDSTAL-GTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSA 173
R P+L Q + EG+ ++ + G L FTL ++ +N L +A L +G++
Sbjct: 208 RIKPELYKQKSVDSEGNQNEDVKICGKLNFTLQYDYENELLVVKIIKALDLPAKDFTGTS 267
Query: 174 DAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAV 233
D YVK LLP K Q R H R T P+++ET + Q + K H +V
Sbjct: 268 DPYVKMYLLPDRKKKFQTRVH--RKTLNPLFDETFQFPVAYDQLSNRKL-------HFSV 318
Query: 234 CVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWE-ECGHVL 292
R + +GE+ ++ N D+ E +++ + G ++
Sbjct: 319 YD----FDRFSRHDMIGEV------ILDNLFEVSDLSREATVWKDIHCATTESIDLGEIM 368
Query: 293 LSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNP 352
SLCY G + + V++C +L MD G SDP+V++ L + K KT+ + TLNP
Sbjct: 369 FSLCYLPTAGRMTLTVIKCRNLKAMDITGSSDPYVKVSLMCEGRRLKKRKTTTKKNTLNP 428
Query: 353 EFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHS 412
+NE + P E + Q +L ++V DYD ++ IG + G A G HW E L +
Sbjct: 429 VYNEAIIFDIPPENVDQVSLSIAVMDYDRVGHNEVIGVCRTGLDAEGLGRDHWNEMLAYH 488
Query: 413 DHRLKLWHPLDSKP 426
+ WHPL P
Sbjct: 489 RKPITHWHPLLELP 502
Score = 78.2 bits (191), Expect = 1e-14
Identities = 53/156 (33%), Positives = 85/156 (54%), Gaps = 15/156 (9%)
Query: 238 PMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCY 297
P++QR S+G ++ L K +S D E + E+V+ CG + +L Y
Sbjct: 195 PVLQRGETTTSIGRIKPELYK-----QKSVDS--EGNQNEDVKI------CGKLNFTLQY 241
Query: 298 SSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEE 357
+ L+V +++ L D G SDP+V+++L P+ +K KF+T VHRKTLNP F+E
Sbjct: 242 DYENELLVVKIIKALDLPAKDFTGTSDPYVKMYLLPD--RKKKFQTRVHRKTLNPLFDET 299
Query: 358 FFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 393
F + ++L+ + L SV+D+D + D IG V L
Sbjct: 300 FQFPVAYDQLSNRKLHFSVYDFDRFSRHDMIGEVIL 335
>gi|94536846 synaptotagmin VIII [Homo sapiens]
Length = 401
Score = 108 bits (271), Expect = 7e-24
Identities = 87/301 (28%), Positives = 135/301 (44%), Gaps = 26/301 (8%)
Query: 123 LQPDPEP-EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAYVKANL 181
+QPD + E D+ G L+ +L F+ + + +A L+P G+ D Y + ++
Sbjct: 101 VQPDVDGLESSPGDAQQWGRLQLSLEFDFGSQEIRVGLRQAADLRP--GGTVDPYARVSV 158
Query: 182 LPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQ 241
A + + H RGT PV++ET +H + + TL+ L + P
Sbjct: 159 STQAGHRHETKVH--RGTLCPVFDETCCFH-IPQAELPGATLQVQLFNFKRFSGHEP--- 212
Query: 242 RQWQAPSLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQ 301
LGELR+PL + LE L E+ G + SL Y
Sbjct: 213 -------LGELRLPLGTV------DLQHVLEHWYLLGPPAATQPEQVGELCFSLRYVPSS 259
Query: 302 GGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYS 361
G L V VL L P G ++P+V++ L N K K KT+ + T P FNE F +
Sbjct: 260 GRLTVVVLEARGLRP----GLAEPYVKVQLMLNQRKWKKRKTATKKGTAAPYFNEAFTFL 315
Query: 362 GPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWHP 421
P ++ L+++VWD L + +G V LG+ ASG+ L+HW + L H+ + HP
Sbjct: 316 VPFSQVQNVDLVLAVWDRSLPLRTEPVGKVHLGARASGQPLQHWADMLAHARRPIAQRHP 375
Query: 422 L 422
L
Sbjct: 376 L 376
>gi|28376627 synaptotagmin IX [Homo sapiens]
Length = 491
Score = 108 bits (269), Expect = 1e-23
Identities = 86/297 (28%), Positives = 133/297 (44%), Gaps = 19/297 (6%)
Query: 130 EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLA-SGSADAYVKANLLPGASKA 188
+G +S A G L F L ++ D L H+A L SG++D YVK LLP
Sbjct: 212 DGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTK 271
Query: 189 SQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPS 248
Q + H R T PV++E + D E + L + R +
Sbjct: 272 HQTKVH--RKTLNPVFDEVFLFP-VPYNDLEARKLHFSVYDFD----------RFSRHDL 318
Query: 249 LGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGV 308
+G++ V + + R C+ + +E V + + G ++ SLCY G L + +
Sbjct: 319 IGQVVVDHFLDLADFPRE---CILWKDIEYVTNDNV--DLGELMFSLCYLPTAGRLTITI 373
Query: 309 LRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELA 368
++ +L MD G SDP+V++ L + + K KTS R TLNP +NE + P E +
Sbjct: 374 IKARNLKAMDITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENID 433
Query: 369 QKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLRHWLECLGHSDHRLKLWHPLDSK 425
Q L ++V DYD ++ IG Q+G+ A HW E L + + WH L K
Sbjct: 434 QIHLSIAVMDYDRVGHNEIIGVCQVGNEAERLGRDHWSEMLSYPRKPIAHWHSLVEK 490
Score = 74.7 bits (182), Expect = 2e-13
Identities = 55/182 (30%), Positives = 88/182 (48%), Gaps = 21/182 (11%)
Query: 229 GHQAVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDIC-LEKRR----LEEVETEV 283
G Q C G VQRQ P+ +R+ + F+I L+K+ + ++ E+
Sbjct: 143 GIQENCAHGVRVQRQVTEPTSSARHNSIRRQLNLSNPDFNIQQLQKQEQLTGIGRIKPEL 202
Query: 284 AWEE--------------CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRL 329
+ CG + L Y L+V + + +L D +G SDP+V++
Sbjct: 203 YKQRSLDNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKI 262
Query: 330 FLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIG 389
+L P+ +K+K +T VHRKTLNP F+E F + P +L + L SV+D+D + D IG
Sbjct: 263 YLLPD--RKTKHQTKVHRKTLNPVFDEVFLFPVPYNDLEARKLHFSVYDFDRFSRHDLIG 320
Query: 390 GV 391
V
Sbjct: 321 QV 322
>gi|216548478 synaptotagmin XI [Homo sapiens]
Length = 431
Score = 100 bits (250), Expect = 2e-21
Identities = 84/296 (28%), Positives = 140/296 (47%), Gaps = 27/296 (9%)
Query: 134 DDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL--ASGSADAYVKANLLPGASKASQL 191
++ LG+L F++ + AL T A GL + + +D Y+K +LP K ++
Sbjct: 153 EEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDDQTQGSDPYIKMTILP--DKRHRV 210
Query: 192 RTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSLGE 251
+T +R T PV++ET T++G + DL H V R + +GE
Sbjct: 211 KTRVLRKTLDPVFDETFTFYGIPYSQLQ------DLVLHFLVL----SFDRFSRDDVIGE 260
Query: 252 LRVPLRKLVPNRAR---SFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGV 308
+ VPL + P+ + + DI KR +++ + G + +SL Y + V V
Sbjct: 261 VMVPLAGVDPSTGKVQLTRDII--KRNIQKCISR------GELQVSLSYQPVAQRMTVVV 312
Query: 309 LRCAHLAPMDANGYS-DPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREEL 367
L+ HL MD G S +P+V++ ++ + +K KT V + TLNP FNE F Y P + L
Sbjct: 313 LKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLL 372
Query: 368 AQKTLLVSVWDYDLGTADDFIGGVQLGSHA-SGERLRHWLECLGHSDHRLKLWHPL 422
++ V D+D T ++ +G + LG+H+ + HW E + WH L
Sbjct: 373 PDISIEFLVIDFDRTTKNEVVGRLILGAHSVTASGAEHWREVCESPRKPVAKWHSL 428
>gi|40068038 B/K protein [Homo sapiens]
Length = 474
Score = 95.1 bits (235), Expect = 1e-19
Identities = 86/299 (28%), Positives = 135/299 (45%), Gaps = 35/299 (11%)
Query: 139 LGTLEFTLLFEADNSALHCTAHRAKGLKPLAS--------GSADAYVKANLLPGASKASQ 190
LG L F+ ++ ++ L A+ L P S ++ YVK LLP + Q
Sbjct: 185 LGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPDQKNSKQ 244
Query: 191 LRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRS---DLGGHQAVCVRGPMVQRQWQAP 247
T R T+ PV+EE T+ +A+ +TL D CV
Sbjct: 245 --TGVKRKTQKPVFEERYTFE-IPFLEAQRRTLLLTVVDFDKFSRHCV------------ 289
Query: 248 SLGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVG 307
+G++ VPL ++ + + L EVE G +LLSL Y G L V
Sbjct: 290 -IGKVSVPLCEVDLVKGGHWWKALIPSSQNEVEL-------GELLLSLNYLPSAGRLNVD 341
Query: 308 VLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREEL 367
V+R L D + SDPFV++ L KTS R T++P +NE F + P+EEL
Sbjct: 342 VIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFKVPQEEL 401
Query: 368 AQKTLLVSVWDYDLGTADDFIGGVQLGSHASG-ERLRHWLECLGHSDHRLKLWHPLDSK 425
+L+ +V+ +++ +++DFIG + +G ++SG HW L ++ WH L S+
Sbjct: 402 ENASLVFTVFGHNMKSSNDFIGRIVIGQYSSGPSETNHWRRMLNTHRTAVEQWHSLRSR 460
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/114 (28%), Positives = 56/114 (49%), Gaps = 9/114 (7%)
Query: 287 ECGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDAN-------GYSDPFVRLFLHPNAGKKS 339
+ G + S Y L V V+ L P ++ +S+P+V++ L P+ +K+
Sbjct: 184 QLGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPD--QKN 241
Query: 340 KFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 393
+T V RKT P F E + + P E ++TLL++V D+D + IG V +
Sbjct: 242 SKQTGVKRKTQKPVFEERYTFEIPFLEAQRRTLLLTVVDFDKFSRHCVIGKVSV 295
Score = 30.8 bits (68), Expect = 2.5
Identities = 26/99 (26%), Positives = 44/99 (44%), Gaps = 2/99 (2%)
Query: 133 SDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKASQL 191
S + LG L +L + L+ RAK L S +D +VK L+ G
Sbjct: 316 SQNEVELGELLLSLNYLPSAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGLKLVKTK 375
Query: 192 RTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGH 230
+T +RGT P + E+ ++ +++ E +L + GH
Sbjct: 376 KTSFLRGTIDPFYNESFSFK-VPQEELENASLVFTVFGH 413
>gi|238550198 synaptotagmin III [Homo sapiens]
Length = 590
Score = 93.2 bits (230), Expect = 4e-19
Identities = 49/106 (46%), Positives = 68/106 (64%), Gaps = 2/106 (1%)
Query: 288 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 347
CG + +L Y L+V +L+ L D+NG+SDP+V+++L P+ +K KF+T VHR
Sbjct: 300 CGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD--RKKKFQTKVHR 357
Query: 348 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 393
KTLNP FNE F +S P ELAQ+ L SV+D+D + D IG V L
Sbjct: 358 KTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
Score = 90.5 bits (223), Expect = 3e-18
Identities = 81/294 (27%), Positives = 126/294 (42%), Gaps = 20/294 (6%)
Query: 131 GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKAS 189
G++ G + F L + + L +A L S G +D YVK LLP K
Sbjct: 292 GEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKF 351
Query: 190 QLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSL 249
Q + H R T PV+ ET + + A+ K H +V + +
Sbjct: 352 QTKVH--RKTLNPVFNETFQFSVPLAELAQRKL-------HFSVYDFDRFSRHDLIGQVV 402
Query: 250 GELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVL 309
+ + L + P+R DI VE + G + SLCY G L V ++
Sbjct: 403 LDNLLELAEQPPDRPLWRDI---------VEGGSEKADLGELNFSLCYLPTAGRLTVTII 453
Query: 310 RCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQ 369
+ ++L MD G+SDP+V+ L + K KTS+ + TLNP +NE + E +
Sbjct: 454 KASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVEN 513
Query: 370 KTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HWLECLGHSDHRLKLWHPL 422
L ++V DYD ++ IG ++G A+ R HW E L + ++ WH L
Sbjct: 514 VGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQL 567
Score = 37.7 bits (86), Expect = 0.020
Identities = 25/82 (30%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 130 EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKA 188
EG S+ + LG L F+L + L T +A LK + +G +D YVKA+L+ +
Sbjct: 424 EGGSEKAD-LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRL 482
Query: 189 SQLRTHTVRGTRVPVWEETLTY 210
+ +T + T P + E L +
Sbjct: 483 KKRKTSIKKNTLNPTYNEALVF 504
>gi|238550196 synaptotagmin III [Homo sapiens]
Length = 590
Score = 93.2 bits (230), Expect = 4e-19
Identities = 49/106 (46%), Positives = 68/106 (64%), Gaps = 2/106 (1%)
Query: 288 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 347
CG + +L Y L+V +L+ L D+NG+SDP+V+++L P+ +K KF+T VHR
Sbjct: 300 CGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD--RKKKFQTKVHR 357
Query: 348 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 393
KTLNP FNE F +S P ELAQ+ L SV+D+D + D IG V L
Sbjct: 358 KTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
Score = 90.5 bits (223), Expect = 3e-18
Identities = 81/294 (27%), Positives = 126/294 (42%), Gaps = 20/294 (6%)
Query: 131 GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKAS 189
G++ G + F L + + L +A L S G +D YVK LLP K
Sbjct: 292 GEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKF 351
Query: 190 QLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSL 249
Q + H R T PV+ ET + + A+ K H +V + +
Sbjct: 352 QTKVH--RKTLNPVFNETFQFSVPLAELAQRKL-------HFSVYDFDRFSRHDLIGQVV 402
Query: 250 GELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVL 309
+ + L + P+R DI VE + G + SLCY G L V ++
Sbjct: 403 LDNLLELAEQPPDRPLWRDI---------VEGGSEKADLGELNFSLCYLPTAGRLTVTII 453
Query: 310 RCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQ 369
+ ++L MD G+SDP+V+ L + K KTS+ + TLNP +NE + E +
Sbjct: 454 KASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVEN 513
Query: 370 KTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HWLECLGHSDHRLKLWHPL 422
L ++V DYD ++ IG ++G A+ R HW E L + ++ WH L
Sbjct: 514 VGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQL 567
Score = 37.7 bits (86), Expect = 0.020
Identities = 25/82 (30%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 130 EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKA 188
EG S+ + LG L F+L + L T +A LK + +G +D YVKA+L+ +
Sbjct: 424 EGGSEKAD-LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRL 482
Query: 189 SQLRTHTVRGTRVPVWEETLTY 210
+ +T + T P + E L +
Sbjct: 483 KKRKTSIKKNTLNPTYNEALVF 504
>gi|14150054 synaptotagmin III [Homo sapiens]
Length = 590
Score = 93.2 bits (230), Expect = 4e-19
Identities = 49/106 (46%), Positives = 68/106 (64%), Gaps = 2/106 (1%)
Query: 288 CGHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHR 347
CG + +L Y L+V +L+ L D+NG+SDP+V+++L P+ +K KF+T VHR
Sbjct: 300 CGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPD--RKKKFQTKVHR 357
Query: 348 KTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQL 393
KTLNP FNE F +S P ELAQ+ L SV+D+D + D IG V L
Sbjct: 358 KTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVL 403
Score = 90.5 bits (223), Expect = 3e-18
Identities = 81/294 (27%), Positives = 126/294 (42%), Gaps = 20/294 (6%)
Query: 131 GDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPGASKAS 189
G++ G + F L + + L +A L S G +D YVK LLP K
Sbjct: 292 GEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKF 351
Query: 190 QLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPSL 249
Q + H R T PV+ ET + + A+ K H +V + +
Sbjct: 352 QTKVH--RKTLNPVFNETFQFSVPLAELAQRKL-------HFSVYDFDRFSRHDLIGQVV 402
Query: 250 GELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCYSSQQGGLLVGVL 309
+ + L + P+R DI VE + G + SLCY G L V ++
Sbjct: 403 LDNLLELAEQPPDRPLWRDI---------VEGGSEKADLGELNFSLCYLPTAGRLTVTII 453
Query: 310 RCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNPEFNEEFFYSGPREELAQ 369
+ ++L MD G+SDP+V+ L + K KTS+ + TLNP +NE + E +
Sbjct: 454 KASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVEN 513
Query: 370 KTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HWLECLGHSDHRLKLWHPL 422
L ++V DYD ++ IG ++G A+ R HW E L + ++ WH L
Sbjct: 514 VGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQL 567
Score = 37.7 bits (86), Expect = 0.020
Identities = 25/82 (30%), Positives = 41/82 (50%), Gaps = 2/82 (2%)
Query: 130 EGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPL-ASGSADAYVKANLLPGASKA 188
EG S+ + LG L F+L + L T +A LK + +G +D YVKA+L+ +
Sbjct: 424 EGGSEKAD-LGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRL 482
Query: 189 SQLRTHTVRGTRVPVWEETLTY 210
+ +T + T P + E L +
Sbjct: 483 KKRKTSIKKNTLNPTYNEALVF 504
>gi|193804862 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 90.9 bits (224), Expect = 2e-18
Identities = 86/317 (27%), Positives = 137/317 (43%), Gaps = 36/317 (11%)
Query: 131 GDSDDSTALGTLEFTLLFEADNSAL--HCTAHRAKGLKPLASGSADAYVKANLLPGASKA 188
GD + G + F+L +E +L H A ++ YVK LLP S+
Sbjct: 349 GDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQ 408
Query: 189 SQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPS 248
+ +T R T P+++ETL Y A+ +TL+ + H R +
Sbjct: 409 GKRKTSIKRDTINPLYDETLRYEIPESLLAQ-RTLQFSVWHHG----------RFGRNTF 457
Query: 249 LGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCY----------- 297
LGE + + ++ + L + E T + + G +++SL Y
Sbjct: 458 LGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPSHK-GELVVSLKYIPASKTPVGGD 516
Query: 298 -----SSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNP 352
+ G L V + +L A G SD FV+ +L P K SK KT V +KTLNP
Sbjct: 517 RKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNP 576
Query: 353 EFNEEFFYSGPR-EELAQKTLLVSVWDYDLGTADDFIGGVQL--GSHASGERLRHWLECL 409
+N F Y+G R E+L L ++VWD + ++DF+GGV+L G+ S + W++
Sbjct: 577 HYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDST 636
Query: 410 GHSDHRLKLWHPLDSKP 426
G + LW + P
Sbjct: 637 G---EEVSLWQKMRQYP 650
>gi|193804860 synaptotagmin-like 4 [Homo sapiens]
Length = 671
Score = 90.9 bits (224), Expect = 2e-18
Identities = 86/317 (27%), Positives = 137/317 (43%), Gaps = 36/317 (11%)
Query: 131 GDSDDSTALGTLEFTLLFEADNSAL--HCTAHRAKGLKPLASGSADAYVKANLLPGASKA 188
GD + G + F+L +E +L H A ++ YVK LLP S+
Sbjct: 349 GDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQ 408
Query: 189 SQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAPS 248
+ +T R T P+++ETL Y A+ +TL+ + H R +
Sbjct: 409 GKRKTSIKRDTINPLYDETLRYEIPESLLAQ-RTLQFSVWHHG----------RFGRNTF 457
Query: 249 LGELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGHVLLSLCY----------- 297
LGE + + ++ + L + E T + + G +++SL Y
Sbjct: 458 LGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPSHK-GELVVSLKYIPASKTPVGGD 516
Query: 298 -----SSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKKSKFKTSVHRKTLNP 352
+ G L V + +L A G SD FV+ +L P K SK KT V +KTLNP
Sbjct: 517 RKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNP 576
Query: 353 EFNEEFFYSGPR-EELAQKTLLVSVWDYDLGTADDFIGGVQL--GSHASGERLRHWLECL 409
+N F Y+G R E+L L ++VWD + ++DF+GGV+L G+ S + W++
Sbjct: 577 HYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDST 636
Query: 410 GHSDHRLKLWHPLDSKP 426
G + LW + P
Sbjct: 637 G---EEVSLWQKMRQYP 650
>gi|123173752 synaptotagmin XIV-like [Homo sapiens]
Length = 645
Score = 84.0 bits (206), Expect = 2e-16
Identities = 78/305 (25%), Positives = 138/305 (45%), Gaps = 14/305 (4%)
Query: 129 PEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLKPLASGSADAY-VKANLLPGASK 187
P G S+ + G L+ + A + L T RA+GL +++ V LLPG K
Sbjct: 341 PSGVSEPISKCGDLDVIFEYRAASQKLTVTIVRAQGLPDKDRSGVNSWQVHVVLLPG--K 398
Query: 188 ASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRSDLGGHQAVCVRGPMVQRQWQAP 247
+ RT+ RG PV+ E +T+ +D +R L + + M ++ +
Sbjct: 399 KHRGRTNIQRGPN-PVFREKVTFAKLEPRDVAACAVRFRLYAARKMTRERMMGEKLFYLS 457
Query: 248 SL---GELRVPLRKLVPNRARSFDICLEKRRLEEVETEVAWEECGH-----VLLSLCYSS 299
L GE++V L + S L + ++ + + H +L+ L Y++
Sbjct: 458 HLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSSTQSLSHGGAPELLVGLSYNA 517
Query: 300 QQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHPNAGKK-SKFKTSVHRKTLNPEFNEEF 358
G L V +++ +H + N D + +LFL + G++ S+ KTS+ R NP + E F
Sbjct: 518 TTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVGQEMSRCKTSIRRGQPNPVYKETF 577
Query: 359 FYSGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHASGERLR-HWLECLGHSDHRLK 417
+ +L+ TL++SV++ + IG + LG ++SGE + HW E ++
Sbjct: 578 VFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIALGQNSSGEEEQDHWEEMKETKGQQIC 637
Query: 418 LWHPL 422
WH L
Sbjct: 638 RWHTL 642
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 81.6 bits (200), Expect = 1e-15
Identities = 52/144 (36%), Positives = 79/144 (54%), Gaps = 24/144 (16%)
Query: 289 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP---------NAGKKS 339
G + L + Y G L++ +L+ +L P D NGYSDPFV+++L P NA +
Sbjct: 4696 GEIQLQINYDL--GNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEY 4753
Query: 340 KFKTSVHRKTLNPEFNEEFFY-SGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHAS 398
K +T +K+LNPE+N+ Y S E+L +KTL V+VWDYD +++DF+G V +
Sbjct: 4754 KRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLID---- 4809
Query: 399 GERLRHWLECLGHSDHRLKLWHPL 422
L H D+ + W+PL
Sbjct: 4810 -------LSSTSHLDNTPR-WYPL 4825
Score = 35.8 bits (81), Expect = 0.077
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 12/94 (12%)
Query: 140 GTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPG---------ASKAS 189
G ++ + ++ N +H +A+ L P + G +D +VK LLPG AS
Sbjct: 4696 GEIQLQINYDLGNLIIHIL--QARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEY 4753
Query: 190 QLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTL 223
+ RT V+ + P W +T+ Y + + + KTL
Sbjct: 4754 KRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTL 4787
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 81.6 bits (200), Expect = 1e-15
Identities = 52/144 (36%), Positives = 79/144 (54%), Gaps = 24/144 (16%)
Query: 289 GHVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFVRLFLHP---------NAGKKS 339
G + L + Y G L++ +L+ +L P D NGYSDPFV+++L P NA +
Sbjct: 4696 GEIQLQINYDL--GNLIIHILQARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEY 4753
Query: 340 KFKTSVHRKTLNPEFNEEFFY-SGPREELAQKTLLVSVWDYDLGTADDFIGGVQLGSHAS 398
K +T +K+LNPE+N+ Y S E+L +KTL V+VWDYD +++DF+G V +
Sbjct: 4754 KRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTLEVTVWDYDRFSSNDFLGEVLID---- 4809
Query: 399 GERLRHWLECLGHSDHRLKLWHPL 422
L H D+ + W+PL
Sbjct: 4810 -------LSSTSHLDNTPR-WYPL 4825
Score = 35.8 bits (81), Expect = 0.077
Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 12/94 (12%)
Query: 140 GTLEFTLLFEADNSALHCTAHRAKGLKPLAS-GSADAYVKANLLPG---------ASKAS 189
G ++ + ++ N +H +A+ L P + G +D +VK LLPG AS
Sbjct: 4696 GEIQLQINYDLGNLIIHIL--QARNLVPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAEY 4753
Query: 190 QLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTL 223
+ RT V+ + P W +T+ Y + + + KTL
Sbjct: 4754 KRRTKHVQKSLNPEWNQTVIYKSISMEQLKKKTL 4787
>gi|226342962 synaptotagmin XIV isoform 2 [Homo sapiens]
Length = 600
Score = 80.9 bits (198), Expect = 2e-15
Identities = 90/337 (26%), Positives = 142/337 (42%), Gaps = 42/337 (12%)
Query: 109 LRPAAASAVRSAPQLQP--DPEPEGDSDDSTALGTLEFTLLFEADNSALHCTAHRAKGLK 166
L P SA S+ QL DPEPE GTL+ T +++ L T +
Sbjct: 280 LSPEDMSAQGSSSQLPKPFDPEPEAK------YGTLDVTFDYDSQEQKLLVTVTAVTDIP 333
Query: 167 PL-ASGSADAYVKANLLPGASKASQLRTHTVRGTRVPVWEETLTYHGFTRQDAECKTLRS 225
+G V LLP K + +T RG PV+ ET ++ + S
Sbjct: 334 TYNRTGGNSWQVHLVLLP--IKKQRAKTSIQRGP-CPVFTETFKFNH----------VES 380
Query: 226 DLGGHQAVCVRGPMVQRQWQAPSLGELRVPLRKLVPNRARSFDICLE----------KRR 275
++ G+ AV R V R + +GE L KL S + LE +
Sbjct: 381 EMIGNYAVRFRLYGVHRMKKEKIVGEKIFYLTKLNLQGKMSLPVILEPSYNHSGCDSQMS 440
Query: 276 LEEVETEVAWEECG--------HVLLSLCYSSQQGGLLVGVLRCAHLAPMDANGYSDPFV 327
+ E+ + C +L+ L Y++ G L V++ +H + AN + +V
Sbjct: 441 VSEMSCSESTSSCQSLEHGSVPEILIGLLYNATTGRLSAEVIKGSHFKNLAANRPPNTYV 500
Query: 328 RLFLHPNAGKK-SKFKTSVHRKTLNPEFNEEFFYSGPREELAQKTLLVSVWDYDLGTADD 386
+L L + G++ SK KTS+ R NP + E F + +L+ TL++SV++ +
Sbjct: 501 KLTLLNSMGQEMSKCKTSIRRGQPNPVYKETFVFQVALFQLSDVTLILSVYNKRSMKRKE 560
Query: 387 FIGGVQLGSHASG-ERLRHWLECLGHSDHRLKLWHPL 422
IG + LG ++SG E L HW E ++ WH L
Sbjct: 561 MIGWISLGLNSSGEEELNHWTEMKESKGQQVCRWHAL 597
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,849,140
Number of Sequences: 37866
Number of extensions: 1022901
Number of successful extensions: 4582
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 167
Number of HSP's that attempted gapping in prelim test: 3998
Number of HSP's gapped (non-prelim): 617
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.