Search of human proteins with 239735584

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
         (1323 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa...  2653   0.0  
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa...  2646   0.0  
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa...  2638   0.0  
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap...  2630   0.0  
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...  2494   0.0  
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa...  2487   0.0  
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa...  2479   0.0  
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa...  2472   0.0  
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]     1671   0.0  
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]    1668   0.0  
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]    1656   0.0  
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]    1647   0.0  
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...  1630   0.0  
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...  1557   0.0  
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...  1452   0.0  
gi|118600963 Nik related kinase [Homo sapiens]                        409   e-113
gi|145275208 myosin IIIA [Homo sapiens]                               306   7e-83
gi|134288915 myosin IIIB isoform 1 [Homo sapiens]                     296   9e-80
gi|134288892 myosin IIIB isoform 2 [Homo sapiens]                     296   9e-80
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   273   8e-73
gi|15451902 mitogen-activated protein kinase kinase kinase kinas...   266   1e-70
gi|38570135 mitogen-activated protein kinase kinase kinase kinas...   263   8e-70
gi|14589909 mitogen-activated protein kinase kinase kinase kinas...   263   8e-70
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 260   5e-69
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                 259   9e-69
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...   259   2e-68
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]      253   7e-67
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]       253   7e-67
gi|22035600 mitogen-activated protein kinase kinase kinase kinas...   249   9e-66
gi|110611908 mitogen-activated protein kinase kinase kinase kina...   244   3e-64

>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
            sapiens]
          Length = 1323

 Score = 2653 bits (6877), Expect = 0.0
 Identities = 1323/1323 (100%), Positives = 1323/1323 (100%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
            REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480

Query: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
            QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE
Sbjct: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540

Query: 541  SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
            SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 541  SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600

Query: 601  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
            SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 601  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660

Query: 661  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
            GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 661  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720

Query: 721  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE 780
            SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE
Sbjct: 721  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE 780

Query: 781  ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 840
            ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV
Sbjct: 781  ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 840

Query: 841  GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH 900
            GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH
Sbjct: 841  GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH 900

Query: 901  SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS 960
            SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS
Sbjct: 901  SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS 960

Query: 961  AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG 1020
            AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG
Sbjct: 961  AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG 1020

Query: 1021 VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW 1080
            VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW
Sbjct: 1021 VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW 1080

Query: 1081 LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH 1140
            LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH
Sbjct: 1081 LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH 1140

Query: 1141 KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN 1200
            KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN
Sbjct: 1141 KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN 1200

Query: 1201 ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW 1260
            ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW
Sbjct: 1201 ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW 1260

Query: 1261 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM 1320
            GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM
Sbjct: 1261 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM 1320

Query: 1321 MNW 1323
            MNW
Sbjct: 1321 MNW 1323


>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
            sapiens]
          Length = 1331

 Score = 2646 bits (6858), Expect = 0.0
 Identities = 1323/1331 (99%), Positives = 1323/1331 (99%), Gaps = 8/1331 (0%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
            REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480

Query: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
            QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE
Sbjct: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540

Query: 541  SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
            SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 541  SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600

Query: 601  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
            SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 601  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660

Query: 661  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
            GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 661  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720

Query: 721  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA--------DLTALAK 772
            SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA        DLTALAK
Sbjct: 721  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK 780

Query: 773  ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 832
            ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP
Sbjct: 781  ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 840

Query: 833  GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 892
            GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL
Sbjct: 841  GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 900

Query: 893  PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 952
            PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE
Sbjct: 901  PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 960

Query: 953  DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1012
            DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE
Sbjct: 961  DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1020

Query: 1013 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1072
            ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK
Sbjct: 1021 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1080

Query: 1073 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1132
            LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY
Sbjct: 1081 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1140

Query: 1133 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1192
            AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY
Sbjct: 1141 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1200

Query: 1193 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1252
            IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI
Sbjct: 1201 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1260

Query: 1253 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1312
            HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF
Sbjct: 1261 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1320

Query: 1313 MTLNRNSMMNW 1323
            MTLNRNSMMNW
Sbjct: 1321 MTLNRNSMMNW 1331


>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
            sapiens]
          Length = 1352

 Score = 2638 bits (6837), Expect = 0.0
 Identities = 1323/1352 (97%), Positives = 1323/1352 (97%), Gaps = 29/1352 (2%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
            REQRRHYEEQMRREEERRRAEHEQEY                             KRKQL
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480

Query: 452  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
            EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
Sbjct: 481  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540

Query: 512  SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 571
            SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
Sbjct: 541  SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600

Query: 572  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 631
            QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 601  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660

Query: 632  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 691
            WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 661  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720

Query: 692  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 751
            PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 721  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780

Query: 752  PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 811
            PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES
Sbjct: 781  PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 840

Query: 812  ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 871
            ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET
Sbjct: 841  ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 900

Query: 872  SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 931
            SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS
Sbjct: 901  SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 960

Query: 932  TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 991
            TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT
Sbjct: 961  TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 1020

Query: 992  NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1051
            NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF
Sbjct: 1021 NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1080

Query: 1052 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1111
            QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK
Sbjct: 1081 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1140

Query: 1112 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1171
            VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI
Sbjct: 1141 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1200

Query: 1172 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1231
            FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY
Sbjct: 1201 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1260

Query: 1232 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1291
            GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC
Sbjct: 1261 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1320

Query: 1292 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1323
            ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1321 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352


>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
          Length = 1360

 Score = 2630 bits (6818), Expect = 0.0
 Identities = 1323/1360 (97%), Positives = 1323/1360 (97%), Gaps = 37/1360 (2%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
            REQRRHYEEQMRREEERRRAEHEQEY                             KRKQL
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480

Query: 452  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
            EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
Sbjct: 481  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540

Query: 512  SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 571
            SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
Sbjct: 541  SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600

Query: 572  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 631
            QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 601  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660

Query: 632  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 691
            WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 661  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720

Query: 692  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 751
            PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 721  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780

Query: 752  PEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 803
            PEESRDITRPSRPA        DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 781  PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 840

Query: 804  EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 863
            EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 841  EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 900

Query: 864  GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 923
            GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 901  GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 960

Query: 924  TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 983
            TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 961  TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 1020

Query: 984  SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1043
            SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 1021 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1080

Query: 1044 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1103
            NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1081 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1140

Query: 1104 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1163
            LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1141 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1200

Query: 1164 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1223
            EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1201 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1260

Query: 1224 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1283
            EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1261 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1320

Query: 1284 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1323
            AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1321 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1360


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
            sapiens]
          Length = 1268

 Score = 2494 bits (6465), Expect = 0.0
 Identities = 1258/1323 (95%), Positives = 1262/1323 (95%), Gaps = 55/1323 (4%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
            REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480

Query: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
            QRPVEKKPLYHYKE                                              
Sbjct: 481  QRPVEKKPLYHYKE---------------------------------------------- 494

Query: 541  SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
                 G+ P+  P   +    +IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 495  -----GMSPSEKPAWAK----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 545

Query: 601  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
            SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 546  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605

Query: 661  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
            GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 606  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 665

Query: 721  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE 780
            SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE
Sbjct: 666  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIE 725

Query: 781  ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 840
            ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV
Sbjct: 726  ETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNV 785

Query: 841  GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH 900
            GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH
Sbjct: 786  GMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSH 845

Query: 901  SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS 960
            SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS
Sbjct: 846  SPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESS 905

Query: 961  AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG 1020
            AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG
Sbjct: 906  AAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWG 965

Query: 1021 VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW 1080
            VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW
Sbjct: 966  VNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSW 1025

Query: 1081 LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH 1140
            LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH
Sbjct: 1026 LRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYH 1085

Query: 1141 KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN 1200
            KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN
Sbjct: 1086 KFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGN 1145

Query: 1201 ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW 1260
            ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW
Sbjct: 1146 ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGW 1205

Query: 1261 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM 1320
            GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM
Sbjct: 1206 GEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSM 1265

Query: 1321 MNW 1323
            MNW
Sbjct: 1266 MNW 1268


>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
            sapiens]
          Length = 1276

 Score = 2487 bits (6446), Expect = 0.0
 Identities = 1258/1331 (94%), Positives = 1262/1331 (94%), Gaps = 63/1331 (4%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
            REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480

Query: 481  QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
            QRPVEKKPLYHYKE                                              
Sbjct: 481  QRPVEKKPLYHYKE---------------------------------------------- 494

Query: 541  SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
                 G+ P+  P   +    +IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 495  -----GMSPSEKPAWAK----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 545

Query: 601  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
            SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 546  SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605

Query: 661  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
            GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 606  GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 665

Query: 721  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA--------DLTALAK 772
            SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA        DLTALAK
Sbjct: 666  SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK 725

Query: 773  ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 832
            ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP
Sbjct: 726  ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 785

Query: 833  GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 892
            GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL
Sbjct: 786  GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 845

Query: 893  PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 952
            PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE
Sbjct: 846  PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 905

Query: 953  DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1012
            DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE
Sbjct: 906  DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 965

Query: 1013 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1072
            ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK
Sbjct: 966  ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1025

Query: 1073 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1132
            LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY
Sbjct: 1026 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1085

Query: 1133 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1192
            AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY
Sbjct: 1086 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1145

Query: 1193 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1252
            IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI
Sbjct: 1146 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1205

Query: 1253 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1312
            HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF
Sbjct: 1206 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1265

Query: 1313 MTLNRNSMMNW 1323
            MTLNRNSMMNW
Sbjct: 1266 MTLNRNSMMNW 1276


>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
            sapiens]
          Length = 1297

 Score = 2479 bits (6425), Expect = 0.0
 Identities = 1258/1352 (93%), Positives = 1262/1352 (93%), Gaps = 84/1352 (6%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
            REQRRHYEEQMRREEERRRAEHEQEY                             KRKQL
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480

Query: 452  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
            EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE                 
Sbjct: 481  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE----------------- 523

Query: 512  SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 571
                                              G+ P+  P   +    +IPHLVAVKS
Sbjct: 524  ----------------------------------GMSPSEKPAWAK----EIPHLVAVKS 545

Query: 572  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 631
            QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 546  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 605

Query: 632  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 691
            WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 606  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 665

Query: 692  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 751
            PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 666  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 725

Query: 752  PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 811
            PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES
Sbjct: 726  PEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGES 785

Query: 812  ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 871
            ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET
Sbjct: 786  ETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET 845

Query: 872  SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 931
            SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS
Sbjct: 846  SGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSS 905

Query: 932  TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 991
            TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT
Sbjct: 906  TKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPT 965

Query: 992  NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1051
            NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF
Sbjct: 966  NIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRF 1025

Query: 1052 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1111
            QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK
Sbjct: 1026 QQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYK 1085

Query: 1112 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1171
            VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI
Sbjct: 1086 VVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVI 1145

Query: 1172 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1231
            FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY
Sbjct: 1146 FGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTY 1205

Query: 1232 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1291
            GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC
Sbjct: 1206 GRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLC 1265

Query: 1292 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1323
            ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1266 ERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1297


>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
            sapiens]
          Length = 1305

 Score = 2472 bits (6406), Expect = 0.0
 Identities = 1258/1360 (92%), Positives = 1262/1360 (92%), Gaps = 92/1360 (6%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
            QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360

Query: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
            NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361  NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420

Query: 421  REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
            REQRRHYEEQMRREEERRRAEHEQEY                             KRKQL
Sbjct: 421  REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480

Query: 452  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
            EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE                 
Sbjct: 481  EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE----------------- 523

Query: 512  SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 571
                                              G+ P+  P   +    +IPHLVAVKS
Sbjct: 524  ----------------------------------GMSPSEKPAWAK----EIPHLVAVKS 545

Query: 572  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 631
            QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 546  QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 605

Query: 632  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 691
            WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 606  WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 665

Query: 692  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 751
            PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 666  PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 725

Query: 752  PEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 803
            PEESRDITRPSRPA        DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 726  PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 785

Query: 804  EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 863
            EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 786  EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 845

Query: 864  GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 923
            GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 846  GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 905

Query: 924  TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 983
            TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 906  TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 965

Query: 984  SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1043
            SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 966  SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1025

Query: 1044 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1103
            NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1026 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1085

Query: 1104 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1163
            LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1086 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1145

Query: 1164 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1223
            EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1146 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1205

Query: 1224 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1283
            EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1206 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1265

Query: 1284 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1323
            AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1266 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1305


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 1671 bits (4327), Expect = 0.0
 Identities = 899/1362 (66%), Positives = 1036/1362 (76%), Gaps = 106/1362 (7%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 476  HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
             Q+Q+Q+          P ++KPLYHY  GM+P++KPAWA+EVEER+R+N+Q +SP    
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 525  KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577
            K  +   +P +P  S          ++TPPM RPV+PQ       + H V +K     + 
Sbjct: 541  KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597

Query: 578  ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626
             SQS+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P     
Sbjct: 598  RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652

Query: 627  FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 686
             +  +W+R + + PPKVPQRT+SI+ AL       N S  G    +Q +RASNPDLRR++
Sbjct: 653  -NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSD 704

Query: 687  PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 746
            P  E           S S  P+S      G  P  QAGS ER RV  +SK + SPVL   
Sbjct: 705  PGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-P 746

Query: 747  PAKVKPEESRDITRPSRPADLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEE 806
              K KP++ R  +RP RPAD   L    +E  ++E  RP KK  DYSSSSEE ESSE++E
Sbjct: 747  GNKAKPDDHR--SRPGRPADFVLL----KERTLDEAPRPPKKAMDYSSSSEEVESSEDDE 800

Query: 807  EDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREG 864
            E+GE    +G+    D P     G     +  +V  +  H +E  T     + G     G
Sbjct: 801  EEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----G 847

Query: 865  TLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGT 924
            T++++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S  S++  SG 
Sbjct: 848  TMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGD 899

Query: 925  EYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEAR 981
                G   +  K+SFT FVD  +YQ   + +          AL   E  R +Q +  + R
Sbjct: 900  YQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVR 953

Query: 982  KISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK 1041
            K SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK
Sbjct: 954  KGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGK 1013

Query: 1042 VYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITV 1101
            VY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TV
Sbjct: 1014 VYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTV 1073

Query: 1102 GDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLT 1161
            GD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLT
Sbjct: 1074 GDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLT 1133

Query: 1162 VEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCY 1221
            VEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP TDGMEML+CY
Sbjct: 1134 VEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCY 1193

Query: 1222 EDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMH 1281
            EDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMH
Sbjct: 1194 EDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMH 1253

Query: 1282 KRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1323
            KRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1254 KRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 1668 bits (4320), Expect = 0.0
 Identities = 899/1366 (65%), Positives = 1036/1366 (75%), Gaps = 106/1366 (7%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 476  HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
             Q+Q+Q+          P ++KPLYHY  GM+P++KPAWA+EVEER+R+N+Q +SP    
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 525  KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577
            K  +   +P +P  S          ++TPPM RPV+PQ       + H V +K     + 
Sbjct: 541  KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597

Query: 578  ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626
             SQS+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P     
Sbjct: 598  RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652

Query: 627  FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 686
             +  +W+R + + PPKVPQRT+SI+ AL       N S  G    +Q +RASNPDLRR++
Sbjct: 653  -NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSD 704

Query: 687  PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 746
            P  E           S S  P+S      G  P  QAGS ER RV  +SK + SPVL   
Sbjct: 705  PGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-P 746

Query: 747  PAKVKPEESRDITRPSRPADLTALAKE----LRELRIEETNRPMKKVTDYSSSSEESESS 802
              K KP++ R  +RP RPA       E    L+E  ++E  RP KK  DYSSSSEE ESS
Sbjct: 747  GNKAKPDDHR--SRPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEVESS 804

Query: 803  EEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSI 860
            E++EE+GE    +G+    D P     G     +  +V  +  H +E  T     + G  
Sbjct: 805  EDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-- 854

Query: 861  SREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEM 920
               GT++++ T  E++   H+DSNG+    NLPD+VQ SHSP    TE     S  S++ 
Sbjct: 855  ---GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPPSKD- 903

Query: 921  DSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKL 977
             SG     G   +  K+SFT FVD  +YQ   + +          AL   E  R +Q + 
Sbjct: 904  GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLDQLQY 958

Query: 978  NEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRS 1037
             + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRS
Sbjct: 959  -DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRS 1017

Query: 1038 GQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQG 1097
            GQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQG
Sbjct: 1018 GQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQG 1077

Query: 1098 WITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLL 1157
            W TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H+PLL
Sbjct: 1078 WTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLL 1137

Query: 1158 VDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEM 1217
            VDLTVEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ  ITPHAI+ LP TDGMEM
Sbjct: 1138 VDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEM 1197

Query: 1218 LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDG 1277
            L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDG
Sbjct: 1198 LLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDG 1257

Query: 1278 VFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1323
            VFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1258 VFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 1656 bits (4289), Expect = 0.0
 Identities = 899/1392 (64%), Positives = 1037/1392 (74%), Gaps = 129/1392 (9%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 476  HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
             Q+Q+Q+          P ++KPLYHY  GM+P++KPAWA+EVEER+R+N+Q +SP    
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 525  KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577
            K  +   +P +P  S          ++TPPM RPV+PQ       + H V +K     + 
Sbjct: 541  KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597

Query: 578  ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626
             SQS+ +QPT+ L+ F  + +            S R  + RQNSDPTSE P P P     
Sbjct: 598  RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652

Query: 627  FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ--------- 673
             +  +W+R + + PPKVPQRT+SI+ AL    + G+  A      PR  S          
Sbjct: 653  -NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRA 711

Query: 674  -----------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGG 716
                             P  +SNPDLRR++P  E           S S  P+S      G
Sbjct: 712  ERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----G 756

Query: 717  SQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRE 776
              P  QAGS ER RV  +SK + SPVL     K KP++ R  +RP RPAD   L    +E
Sbjct: 757  HLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KE 807

Query: 777  LRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNE 836
              ++E  RP KK  DYSSSSEE ESSE++EE+GE    +G+    D P     G     +
Sbjct: 808  RTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGD 859

Query: 837  QYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPD 894
              +V  +  H +E  T     + G     GT++++ T  E++   H+DSNG+    NLPD
Sbjct: 860  TDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPD 911

Query: 895  LVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTD 951
            +VQ SHSP    TE     S  S++  SG     G   +  K+SFT FVD  +YQ   + 
Sbjct: 912  VVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSG 966

Query: 952  EDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNS 1011
            +          AL   E  R +Q +  + RK SVVNVNPTN R HS+TPEIRKYKKRFNS
Sbjct: 967  DS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNS 1020

Query: 1012 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKN 1071
            EILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+N
Sbjct: 1021 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRN 1080

Query: 1072 KLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEI 1131
            KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+
Sbjct: 1081 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEV 1140

Query: 1132 YAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDI 1191
            YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS  GFH +DVDSGNSYDI
Sbjct: 1141 YAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDI 1200

Query: 1192 YIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY 1251
            YIP HIQ  ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAY
Sbjct: 1201 YIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAY 1260

Query: 1252 IHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVF 1311
            I SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+
Sbjct: 1261 ICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1320

Query: 1312 FMTLNRNSMMNW 1323
            FMTLNRN +MNW
Sbjct: 1321 FMTLNRNCIMNW 1332


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score = 1647 bits (4266), Expect = 0.0
 Identities = 896/1385 (64%), Positives = 1033/1385 (74%), Gaps = 135/1385 (9%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            M   +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF  FI++CL+K +  RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
            QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ 
Sbjct: 301  QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360

Query: 360  ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
             NK  SEAL++QQ   +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361  ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420

Query: 418  QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
             QE+EQ+R  E+   +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE  YL SLQ
Sbjct: 421  LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480

Query: 476  HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
             Q+Q+Q+          P ++KPLYHY  GM+P++KPAWA+EVEER+R+N+Q +SP    
Sbjct: 481  QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540

Query: 525  KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHE 584
            K  +   +P +P  S          ++TPPM RPV+PQ         +GP     +S+ +
Sbjct: 541  KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQ---------EGP----HKSLQD 584

Query: 585  QPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWL 633
            QPT+ L+ F  + +            S R  + RQNSDPTSE P P P      +  +W+
Sbjct: 585  QPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NPPAWV 638

Query: 634  RQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ---------------- 673
            R + + PPKVPQRT+SI+ AL    + G+  A      PR  S                 
Sbjct: 639  RPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKP 698

Query: 674  ----------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQA 723
                      P  +SNPDLRR++P  E           S S  P+S      G  P  QA
Sbjct: 699  PGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----GHLP--QA 741

Query: 724  GSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPADLTALAKELRELRIEETN 783
            GS ER RV  +SK + SPVL     K KP++ R  +RP RPAD   L    +E  ++E  
Sbjct: 742  GSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVLL----KERTLDEAP 794

Query: 784  RPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMV 843
            RP KK  DYSSSSEE ESSE++EE+GE    +G+    D P     G     +  +V  +
Sbjct: 795  RPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTM 846

Query: 844  GTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHS 901
              H +E  T     + G     GT++++ T  E++   H+DSNG+    NLPD+VQ SHS
Sbjct: 847  VVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHS 898

Query: 902  PAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEE 958
            P    TE     S  S++  SG     G   +  K+SFT FVD  +YQ   + +      
Sbjct: 899  P----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS----- 948

Query: 959  SSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAAL 1018
                AL   E  R +Q +  + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAAL
Sbjct: 949  IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAAL 1007

Query: 1019 WGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYL 1078
            WGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYL
Sbjct: 1008 WGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYL 1067

Query: 1079 SWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKP 1138
            SWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKP
Sbjct: 1068 SWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKP 1127

Query: 1139 YHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQ 1198
            YHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS  GFH +DVDSGNSYDIYIP HIQ
Sbjct: 1128 YHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQ 1187

Query: 1199 GNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIM 1258
              ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIM
Sbjct: 1188 SQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIM 1247

Query: 1259 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRN 1318
            GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN
Sbjct: 1248 GWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRN 1307

Query: 1319 SMMNW 1323
             +MNW
Sbjct: 1308 CIMNW 1312


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
            isoform 2 [Homo sapiens]
          Length = 1320

 Score = 1630 bits (4222), Expect = 0.0
 Identities = 893/1392 (64%), Positives = 1014/1392 (72%), Gaps = 141/1392 (10%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61   DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
            QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE     GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301  QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 359  LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
              NKERSEALRRQQL  EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361  QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420

Query: 417  KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYKRKQLEEQ----- 454
            +QQEREQRR  +E+ RR                 EEE+RR E EQEY R+QLEE+     
Sbjct: 421  RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480

Query: 455  ------------------------RQAERLQRQLKQERDYLVSLQHQRQEQRP------- 483
                                    RQAERLQRQL+QE+ YL+SLQH  +   P       
Sbjct: 481  VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540

Query: 484  ----VEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRS 539
                   KP +H  E  +  E    A+EVE+R R    SSP    K   R+ +P +P RS
Sbjct: 541  PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600

Query: 540  ESFSISGVQPARTPPMLRPVDPQI--PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEAL 597
            ESFS +G   +  P + RP +PQ+   HL ++K+    ++ S S  +   K       + 
Sbjct: 601  ESFS-NGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQ 659

Query: 598  N-VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED-IPPKVPQRTTSISPALA 655
            +     R E+  Q+SD  SE P  PT      + +W R + D +PP+VP RTTS SP L+
Sbjct: 660  DPCPPSRSEVLSQSSDSKSEAPD-PT------QKAWSRSDSDEVPPRVPVRTTSRSPVLS 712

Query: 656  RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 715
            R++SP  GS        Q    S+ + R     +E  + R  SGSSS SS   SQP    
Sbjct: 713  RRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP---- 768

Query: 716  GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAK 772
            GS PGSQ+GS ER RVR++SKSEGSP    E A  KPE+ +++ RP +PA   DLTALAK
Sbjct: 769  GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 828

Query: 773  ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 832
            ELR +   E  RP  KVTDYSSSSEES +++EE++D E E  D + +  +  R   +   
Sbjct: 829  ELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNL 885

Query: 833  GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET-SGEKKRSGHSDSNGFAGHIN 891
             + E  +V  +  H    S     + + S+EGTL++R+T S       H  S+ F   I+
Sbjct: 886  SNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFID 942

Query: 892  LPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTD 951
             P L+Q S S   T T  +G                                        
Sbjct: 943  -PRLLQISPSSGTTVTSVVG---------------------------------------- 961

Query: 952  EDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNS 1011
                         F+ + +R E  + +  RK SVVNVNPTN RP SDTPEIRKYKKRFNS
Sbjct: 962  -------------FSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS 1008

Query: 1012 EILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKN 1071
            EILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+
Sbjct: 1009 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD 1068

Query: 1072 KLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEI 1131
            KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+
Sbjct: 1069 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV 1128

Query: 1132 YAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDI 1191
            YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS  GFH +DVDSG+ YDI
Sbjct: 1129 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI 1188

Query: 1192 YIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY 1251
            Y+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY
Sbjct: 1189 YLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY 1248

Query: 1252 IHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVF 1311
            I SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+
Sbjct: 1249 IRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1308

Query: 1312 FMTLNRNSMMNW 1323
            FMTL R S+++W
Sbjct: 1309 FMTLGRTSLLSW 1320


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
            isoform 3 [Homo sapiens]
          Length = 1212

 Score = 1557 bits (4031), Expect = 0.0
 Identities = 853/1341 (63%), Positives = 969/1341 (72%), Gaps = 147/1341 (10%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61   DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
            QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE     GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301  QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 359  LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
              NKERSEALRRQQL  EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361  QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420

Query: 417  KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
            +QQEREQRR  +E+ RR EE  R   E+E +R+  EE+R+ ER    ++RQL++E+ +L 
Sbjct: 421  RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480

Query: 473  SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISD 532
             LQ Q  +++                      A  + +  R + Q S   P         
Sbjct: 481  VLQQQLLQEQ----------------------AMLLHDHRRPHPQHSQQPP--------- 509

Query: 533  PNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSG 592
               PP+ E          R+ P     +P+                    H +P      
Sbjct: 510  ---PPQQE----------RSKPSFHAPEPK-------------------AHYEPADRARE 537

Query: 593  FQEALNVTSHRVEMPRQNSDPTSE--NPPLPTRIEKFDR----SSWLRQEEDIPPKVPQR 646
             ++    T+H    P   S  T     PP+P+R E F      S     +    P+VP R
Sbjct: 538  VEDRFRKTNH--SSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVR 595

Query: 647  TTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSST 706
            TTS SP L+R++SP  GS        Q    S+ + R     +E  + R  SGSSS SS 
Sbjct: 596  TTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSN 655

Query: 707  PSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA- 765
              SQP    GS PGSQ+GS ER RVR++SKSEGSP    E A  KPE+ +++ RP +PA 
Sbjct: 656  SGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG 711

Query: 766  --DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDI 823
              DLTALAKELR +   E  RP  KVTDYSSSSEES +++EE++D E E  D + +  + 
Sbjct: 712  EVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPED 768

Query: 824  PRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET-SGEKKRSGHSD 882
             R   +    + E  +V  +  H    S     + + S+EGTL++R+T S       H  
Sbjct: 769  TRAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASSTLQKHKS 825

Query: 883  SNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDP 942
            S+ F   I+ P L+Q S S   T T  +G                               
Sbjct: 826  SSSFTPFID-PRLLQISPSSGTTVTSVVG------------------------------- 853

Query: 943  RVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEI 1002
                                  F+ + +R E  + +  RK SVVNVNPTN RP SDTPEI
Sbjct: 854  ----------------------FSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEI 891

Query: 1003 RKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNV 1062
            RKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNV
Sbjct: 892  RKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNV 951

Query: 1063 LVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLV 1122
            LVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLV
Sbjct: 952  LVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLV 1011

Query: 1123 IALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVID 1182
            IALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS  GFH +D
Sbjct: 1012 IALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVD 1071

Query: 1183 VDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQW 1242
            VDSG+ YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQW
Sbjct: 1072 VDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQW 1131

Query: 1243 GEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASV 1302
            GEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASV
Sbjct: 1132 GEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASV 1191

Query: 1303 RSGGSSQVFFMTLNRNSMMNW 1323
            RSGGSSQV+FMTL R S+++W
Sbjct: 1192 RSGGSSQVYFMTLGRTSLLSW 1212


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
            isoform 1 [Homo sapiens]
          Length = 1166

 Score = 1452 bits (3759), Expect = 0.0
 Identities = 821/1343 (61%), Positives = 933/1343 (69%), Gaps = 197/1343 (14%)

Query: 1    MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
            MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT 
Sbjct: 1    MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60

Query: 61   DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
            DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61   DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120

Query: 121  KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
            KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121  KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180

Query: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
            TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181  TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240

Query: 241  ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
            ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241  ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300

Query: 301  QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
            QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE     GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301  QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360

Query: 359  LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ 418
              NKERSEALRRQQL                               L+EQQ RE+E  K+
Sbjct: 361  QENKERSEALRRQQL-------------------------------LQEQQLREQEEYKR 389

Query: 419  QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR 478
            Q   +R+   EQ +  E+RRR E +Q   R++ E +RQ ER QR+ +QE           
Sbjct: 390  QLLAERQKRIEQQK--EQRRRLEEQQ---RREREARRQQEREQRRREQE----------- 433

Query: 479  QEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPR 538
             E+R +E              E     KE EER R   +           R+       R
Sbjct: 434  -EKRRLE--------------ELERRRKEEEERRRAEEEK---------RRVE------R 463

Query: 539  SESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSV----HEQPTKGLSGFQ 594
             + +            + R ++ +  HL  ++ Q   L   Q++    H +P        
Sbjct: 464  EQEY------------IRRQLEEEQRHLEVLQQQ---LLQEQAMLLHDHRRPHP------ 502

Query: 595  EALNVTSHRVEMP---RQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSIS 651
                   H  + P   ++ S P+   P      E  DR+           +VP RTTS S
Sbjct: 503  ------QHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAR----------EVPVRTTSRS 546

Query: 652  PALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQP 711
            P L+R++SP  GS        Q    S+ + R     +E  + R  SGSSS SS   SQP
Sbjct: 547  PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP 606

Query: 712  SSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLT 768
                GS PGSQ+GS ER RVR++SKSEGSP    E A  KPE+ +++ RP +PA   DLT
Sbjct: 607  ----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLT 662

Query: 769  ALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIP 828
            ALAKELR +   E  RP  KVTDYSSSSEES +++EE++D E E                
Sbjct: 663  ALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE---------------- 703

Query: 829  TGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAG 888
                G++E        T G E + A S          L   ET   K    H D      
Sbjct: 704  ----GADES-------TSGPEDTRAASSLN-------LSNGETESVKTMIVHDDVES--- 742

Query: 889  HINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTS 948
                         PA TP++    +   +Q   S  +    SS   SFTPF+DPR+ Q S
Sbjct: 743  ------------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTPFIDPRLLQIS 787

Query: 949  PTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKR 1008
            P+         ++   F+ + +R E  + +  RK SVVNVNPTN RP SDTPEIRKYKKR
Sbjct: 788  PSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKR 843

Query: 1009 FNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISG 1068
            FNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISG
Sbjct: 844  FNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISG 903

Query: 1069 KKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNA 1128
            KK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++
Sbjct: 904  KKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSS 963

Query: 1129 VEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNS 1188
            VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS  GFH +DVDSG+ 
Sbjct: 964  VEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSV 1023

Query: 1189 YDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVL 1240
            YDIY+P+H++ N        I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVL
Sbjct: 1024 YDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVL 1083

Query: 1241 QWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFA 1300
            QWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFA
Sbjct: 1084 QWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFA 1143

Query: 1301 SVRSGGSSQVFFMTLNRNSMMNW 1323
            SVRSGGSSQV+FMTL R S+++W
Sbjct: 1144 SVRSGGSSQVYFMTLGRTSLLSW 1166


>gi|118600963 Nik related kinase [Homo sapiens]
          Length = 1582

 Score =  409 bits (1050), Expect = e-113
 Identities = 268/717 (37%), Positives = 386/717 (53%), Gaps = 73/717 (10%)

Query: 1   MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59
           MA     R  +  DL  L DP GIF L + +G GTYG++Y G H KTG   A+KVM+   
Sbjct: 1   MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60

Query: 60  -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96
                                   DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 61  TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120

Query: 97  MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156
              QLW+VME C AGSVTD+++ T   +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180

Query: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216
           QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P  +YD++SD+
Sbjct: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240

Query: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276
           WS+GITAIEMAEGAPPLC++ P+ ALF+I R  AP +KS  WS+KF +F+E C +KN   
Sbjct: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300

Query: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333
           RP +  +++HPF+RD  NER V   L  H+    KKR +K      E E +  E+     
Sbjct: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360

Query: 334 DSGEPS---SILNLPGESTLRRDFLRL---------QLANKERSEALRRQQLEQQQRENE 381
             G PS    +L LP  S  R   LR+          L ++E  +    QQL+   R   
Sbjct: 361 FRG-PSCTHELLRLPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAAR--V 415

Query: 382 EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE 441
               Q L    K ++ Q +  +RL+   R    L+ Q + +  +  + Q++     RRA 
Sbjct: 416 FMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAA 475

Query: 442 ------HEQEYKRKQLEEQRQA---ERLQRQLKQERDY-LVSLQHQRQEQRPVEKKPLYH 491
                   Q    + L+ Q Q    ++ Q Q  + +D   V  + Q Q+Q P ++     
Sbjct: 476 RVLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQ----- 530

Query: 492 YKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNL------PPRSESFSIS 545
            ++G +P ++    +  E+   L +  +P  P +V  + ++P         P S   +  
Sbjct: 531 -RQGQAPEQQQRHNQVPEQ--ELEQNQAPEQP-EVQEQAAEPAQAETEAEEPESLRVNAQ 586

Query: 546 GVQP--ARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHR 603
              P  ++   +L P+      L+ V+ Q      +Q+   +P + +   Q  +   S R
Sbjct: 587 VFLPLLSQDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLS-R 645

Query: 604 VEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
             +   NS+ +    PL T +E    + +  Q E    K   + +++  ALA++ SP
Sbjct: 646 DLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLRQALAKRLSP 701



 Score =  274 bits (701), Expect = 4e-73
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)

Query: 960  SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 1017
            SA A F S +L     ++ E   ++ S VNVNP  + P    P I  Y+K F SEI C +
Sbjct: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216

Query: 1018 LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1077
            LWGVNLL+GT + L L+DRSG+  +  LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276

Query: 1078 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1129
            L+WLRN+IL+NDPE +++Q  +         +  L GC H+ V+++E   ++ IALK+++
Sbjct: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336

Query: 1130 EIYAWAPK---------------------------------------PYHKF-------- 1142
             +YAWAPK                                       P ++F        
Sbjct: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396

Query: 1143 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1201
             +  K F  L HKP+ VDL +   +RLK+ F S  G+H+ID +S    D+ +P +    I
Sbjct: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456

Query: 1202 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1261
             P  I+ILP   G+ M++ +  E + V    ++ K ++  W ++P+S+A+  + +  GWG
Sbjct: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516

Query: 1262 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1317
            +KAIE+RS+++  L+     +  ++L+FLC R DK+FF S      S+V+FMTL +
Sbjct: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572



 Score = 40.8 bits (94), Expect = 0.009
 Identities = 41/190 (21%), Positives = 81/190 (42%), Gaps = 21/190 (11%)

Query: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401
           L RD LR   +N  +         E L   +   Q  +  E K ++   RQ   +    +
Sbjct: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702

Query: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQA 457
           R R +   R EK    +L  +++R QRR  +   + EEE R+ + ++E +    +E   +
Sbjct: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS 762

Query: 458 ERLQRQLKQERDYLVSLQ----HQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK-----EV 508
            + + Q++  + Y+ + +     +R    P  +   +H K   S  ++    +     ++
Sbjct: 763 IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDI 822

Query: 509 EERSRLNRQS 518
            +RS  NRQ+
Sbjct: 823 RQRSSQNRQN 832


>gi|145275208 myosin IIIA [Homo sapiens]
          Length = 1616

 Score =  306 bits (785), Expect = 7e-83
 Identities = 155/311 (49%), Positives = 207/311 (66%), Gaps = 11/311 (3%)

Query: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHH 79
           DP+  +E+ E +G GTYG+V+K  + K GQ AA+K++D   D +EEI+ E N+LK  S H
Sbjct: 16  DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75

Query: 80  RNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN--TKGNTLKEEWIAYICREI 137
            N+  +YG + KK+     D+LWLV+E C  GSVTDL+K    +G  + E  IAYI  E 
Sbjct: 76  PNVVRFYGIYFKKDKVN-GDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L GL HLH +K IHRD+KG N+LLT    VKLVDFGVSAQL  T  RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
           EVIAC++  D TYD + D WSLGITAIE+ +G PPL D+HPMRALF IPRNP P+L+  +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254

Query: 258 -WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-----RDQPNERQVR--IQLKDHIDRT 309
            WS +F  FI  CL K++ +RP   +L++H FI     +D   ++Q+   I +   +  T
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEFIGIHQCMGGT 314

Query: 310 KKKRGEKDETE 320
           +K R E+  T+
Sbjct: 315 EKARRERIHTK 325



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 44/211 (20%), Positives = 83/211 (39%), Gaps = 28/211 (13%)

Query: 281  EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSS 340
            E+ +K  F    P     +  +KD  + +  ++ EK+E   +       EE N     ++
Sbjct: 1197 EEEVKQEFYLVGPEVSPKQKSVKDLEENSNLRKVEKEEAMIQSYYQRYTEERNCEESKAA 1256

Query: 341  ILNLPGESTLRRDFLRLQLANKERS------EALRRQQLEQQQRENEEHKRQLLAERQKR 394
             L     S  R  +    LA  E S        L ++ + Q     E+ K+  +  ++  
Sbjct: 1257 YLERKAISE-RPSYPVPWLAENETSFKKTLEPTLSQRSIYQNANSMEKEKKTSVVTQRAP 1315

Query: 395  IEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQ 454
            I  Q+E R RL                   RH   + R+ E   +A+ E++     ++ +
Sbjct: 1316 ICSQEEGRGRL-------------------RHETVKERQVEPVTQAQEEEDKAAVFIQSK 1356

Query: 455  RQAERLQRQLKQERDYLVSLQHQRQEQRPVE 485
             +  + ++QL+  +D + S +HQR    P E
Sbjct: 1357 YRGYKRRQQLR--KDKMSSFKHQRIVTTPTE 1385


>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
          Length = 1314

 Score =  296 bits (758), Expect = 9e-80
 Identities = 152/328 (46%), Positives = 211/328 (64%), Gaps = 11/328 (3%)

Query: 13  IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72
           + L +L DP   +E++E +G GTYG+VYK  + + G LAA+K++D   D +EEI+ E N+
Sbjct: 15  LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74

Query: 73  LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK--GNTLKEEWI 130
           L+   +H N+  +YG F K +   +  QLWLV+E C  GSVT+L+K     G  L E  I
Sbjct: 75  LQFLPNHPNVVKFYGMFYKADHC-VGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133

Query: 131 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
           +YI    L GL HLH +++IHRD+KG N+LLT    VKLVDFGVSAQL  T  RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193

Query: 191 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA 250
           TP+WMAPEVIAC++  D++YD + D+WSLGITAIE+ +G PPL DMHP++ LF IPRNP 
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253

Query: 251 PR-LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPN-----ERQVRIQLKD 304
           P  L  +KW ++F  FI  CL+K+  +RP+   L+ HPFI+         ++Q+   L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313

Query: 305 --HIDRTKKKRGEKDETEYEYSGSEEEE 330
             H +   K R E+  T   Y   + E+
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAEK 341


>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
          Length = 1341

 Score =  296 bits (758), Expect = 9e-80
 Identities = 152/328 (46%), Positives = 211/328 (64%), Gaps = 11/328 (3%)

Query: 13  IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72
           + L +L DP   +E++E +G GTYG+VYK  + + G LAA+K++D   D +EEI+ E N+
Sbjct: 15  LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74

Query: 73  LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK--GNTLKEEWI 130
           L+   +H N+  +YG F K +   +  QLWLV+E C  GSVT+L+K     G  L E  I
Sbjct: 75  LQFLPNHPNVVKFYGMFYKADHC-VGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133

Query: 131 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
           +YI    L GL HLH +++IHRD+KG N+LLT    VKLVDFGVSAQL  T  RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193

Query: 191 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA 250
           TP+WMAPEVIAC++  D++YD + D+WSLGITAIE+ +G PPL DMHP++ LF IPRNP 
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253

Query: 251 PR-LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPN-----ERQVRIQLKD 304
           P  L  +KW ++F  FI  CL+K+  +RP+   L+ HPFI+         ++Q+   L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313

Query: 305 --HIDRTKKKRGEKDETEYEYSGSEEEE 330
             H +   K R E+  T   Y   + E+
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAEK 341


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  273 bits (698), Expect = 8e-73
 Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)

Query: 6   PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
           P R L ++D  +L + P  +F+++E +G G+YG VYK  H +TGQ+ AIK + V  D +E
Sbjct: 10  PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69

Query: 65  EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
            IK+   M +  S H  +  YYG++ K         LW+VME+CGAGSV+D+I+  +  T
Sbjct: 70  IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120

Query: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
           L E+ IA I +  L+GL +LH  + IHRDIK  N+LL      KL DFGV+ QL  T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180

Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
           RNT IGTP+WMAPEVI      +  Y+  +D+WSLGITAIEMAEG PP  D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235

Query: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
           IP NP P   K + WS  F  F++ CLVK+  QR    QL++HPF+R       +R  + 
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295

Query: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
           + +D  K KR E  + E +    E  EE+E DSG   +++   G+   T+R        A
Sbjct: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351

Query: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
           N   E  + L  Q         +E +   +  R + ++  K       EQ+ +E ++
Sbjct: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408


>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
           [Homo sapiens]
          Length = 894

 Score =  266 bits (679), Expect = 1e-70
 Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)

Query: 14  DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
           DLS  R+P   FEL++ +G+GTYG VYK R+V TG+LAAIKV+ +   E+  + Q+  ++
Sbjct: 6   DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64

Query: 74  KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
            K   H NI  Y+G+++++      D+LW+ MEFCG GS+ D+   T    L E  IAY+
Sbjct: 65  MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116

Query: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
            RE L+GL +LH    +HRDIKG N+LLT+N  VKL DFGVSAQ+  T+ +R +FIGTPY
Sbjct: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176

Query: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
           WMAPEV A +      Y+   DLW++GITAIE+AE  PP+ D+HPMRALFL+ ++    P
Sbjct: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234

Query: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
           +LK K KWS  F  F++  L KN  +RP  E+L++HPF+  Q   R + I+L D ++
Sbjct: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290


>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  263 bits (672), Expect = 8e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73

Query: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242

Query: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295

Query: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349

Query: 365 SEALRRQQL 373
            E   R ++
Sbjct: 350 KETEARDEM 358


>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  263 bits (672), Expect = 8e-70
 Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)

Query: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
           R+P   +ELV+ VG+GTYG VYK R+V TG+LAA+K++ +  GD+   I+QEI M+K+  
Sbjct: 14  RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73

Query: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
           H  NI  Y+G+++ +      ++LW+ ME+CG GS+ D+   T    L E  IAY+CRE 
Sbjct: 74  HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL++LH    +HRDIKG N+LLT++ +VKL DFGV+A++  T+ +R +FIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
           EV A ++N    Y+   D+W++GITAIE+ E  PP+ D+HPMRALFL+ ++    P+LK 
Sbjct: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242

Query: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
           K KWS  F +F++  L KN  +RP  E+L+ H F+      R + ++L D ++       
Sbjct: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295

Query: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
              +    Y+     E ++D  EP +I+     ST R           +F +LQ     R
Sbjct: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349

Query: 365 SEALRRQQL 373
            E   R ++
Sbjct: 350 KETEARDEM 358


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  260 bits (665), Expect = 5e-69
 Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)

Query: 2   ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
           A  S  + L E  L+  + P  +F+++E +G G+YG V+K  H ++GQ+ AIK + V  D
Sbjct: 6   APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63

Query: 62  EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
            +E IK EI+++++      +  YYG++ K         LW+VME+CGAGSV+D+I+  +
Sbjct: 64  LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114

Query: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
             TL E+ IA I +  L+GL +LH  + IHRDIK  N+LL      KL DFGV+ QL  T
Sbjct: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174

Query: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
           + +RNT IGTP+WMAPEVI      +  Y+  +D+WSLGIT+IEMAEG PP  D+HPMRA
Sbjct: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229

Query: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
           +F+IP NP P   K + WS  F  F++ CLVKN  QR    QL++HPFI+   N + V I
Sbjct: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286

Query: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
            L+D I      K KR E+ + E E      +E+E DS
Sbjct: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score =  259 bits (663), Expect = 9e-69
 Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)

Query: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
           DP  +F  ++ +G G++G+VYKG    T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74

Query: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
               I  Y+G+++K        +LW++ME+ G GS  DL+K      L+E +IA I REI
Sbjct: 75  SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL +LH  + IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
           EVI       + YDFK+D+WSLGITAIE+A+G PP  D+HPMR LFLIP+N  P L+ + 
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239

Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
            SK F+ F+E+CL K+   RP  ++L+KH FI     +     +L D   R K + G  +
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297

Query: 318 ETEYEYSGSEEEEEENDSG 336
           E+  E S  + E E+ + G
Sbjct: 298 ESSSEDSDIDGEAEDGEQG 316


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score =  259 bits (661), Expect = 2e-68
 Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)

Query: 18  LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
           + DP  +F  +E +G G++G+V+KG   +T Q+ AIK++D+    DE E+I+QEI +L +
Sbjct: 17  IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76

Query: 76  YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
                 +  YYG+++K +      +LW++ME+ G GS  DL++        E  IA + +
Sbjct: 77  CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126

Query: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
           EIL+GL +LH  K IHRDIK  NVLL+E  +VKL DFGV+ QL  T  +RNTF+GTP+WM
Sbjct: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186

Query: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
           APEVI       + YD K+D+WSLGITAIE+A+G PP  DMHPMR LFLIP+N  P L  
Sbjct: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241

Query: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
             ++K F+ FI++CL K+ S RP  ++L+KH FI     +     +L D   R K +   
Sbjct: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300

Query: 316 KDETEYEYSGSEEEEEENDS 335
            DE++ E S SE    EN++
Sbjct: 301 DDESDSEGSDSESTSRENNT 320


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score =  253 bits (647), Expect = 7e-67
 Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)

Query: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
           DP  +F  +E +G G++G+V+KG   +T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 19  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

Query: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
               +  YYG+++K      D +LW++ME+ G GS  DL++      L E  IA I REI
Sbjct: 79  SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL +LH  K IHRDIK  NVLL+E+ EVKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
           EVI       + YD K+D+WSLGITAIE+A G PP  ++HPM+ LFLIP+N  P L+   
Sbjct: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242

Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
           +SK  + F+E+CL K  S RP  ++L+KH FI     +     +L   IDR K+ + E+ 
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298

Query: 318 ETEYEYSGSEEEEEEND 334
              ++ S SE+ + E D
Sbjct: 299 --SHDDSSSEDSDAETD 313


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score =  253 bits (647), Expect = 7e-67
 Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)

Query: 20  DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
           DP  +F  +E +G G++G+V+KG   +T ++ AIK++D+    DE E+I+QEI +L +  
Sbjct: 31  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90

Query: 78  HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
               +  YYG+++K      D +LW++ME+ G GS  DL++      L E  IA I REI
Sbjct: 91  SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140

Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
           L+GL +LH  K IHRDIK  NVLL+E+ EVKL DFGV+ QL  T  +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200

Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
           EVI       + YD K+D+WSLGITAIE+A G PP  ++HPM+ LFLIP+N  P L+   
Sbjct: 201 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 254

Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
           +SK  + F+E+CL K  S RP  ++L+KH FI     +     +L   IDR K+ + E+ 
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 310

Query: 318 ETEYEYSGSEEEEEEND 334
              ++ S SE+ + E D
Sbjct: 311 --SHDDSSSEDSDAETD 325


>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
           [Homo sapiens]
          Length = 820

 Score =  249 bits (637), Expect = 9e-66
 Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)

Query: 17  ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
           +L+DP   FEL++ VG GTYG VYK R   T +LAA+K++ +  GD+   ++QEI +L++
Sbjct: 8   SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67

Query: 76  YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
              H N+  Y G++++      +D+LW+ MEFCG GS+ ++   T    L+E  IAY+CR
Sbjct: 68  -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118

Query: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
           E L+GL HLH    IHRDIKG N+LLT   +VKL DFGVS +L  +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178

Query: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
           APEV A +      Y+   D+W+LGITAIE+ E  PPL  +HPMRAL L+ ++    P+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236

Query: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
           + K +W++ F  F++  L KN  +RP  E+L++HPF   Q
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276


>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
           1 isoform 1 [Homo sapiens]
          Length = 821

 Score =  244 bits (624), Expect = 3e-64
 Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)

Query: 19  RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78
           RDP   ++L++ +G GTYG+V+K R   +G L A+K++ +  D++    Q+  ++ K   
Sbjct: 11  RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70

Query: 79  HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
           H NI  Y+G+++         +LW+ MEFCGAGS+ D+ + T   +L E  I+Y+CRE+L
Sbjct: 71  HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122

Query: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
           +GL++LH  K IHRDIKG N+L+ +  EV+L DFG+SAQ+  T+ RR +FIGTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182

Query: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256
           V A        Y+   D+WSLGITAIE+AE  PPL D+HP+R LFL+ ++    PRLK K
Sbjct: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240

Query: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
            KWS  F +FI+  L K+  +RP+  +++ H  +      R + + L D +    K    
Sbjct: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300

Query: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
            D  + E            S   SS L +P     RR     +L   E        +L+ 
Sbjct: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360

Query: 376 QQRENEEHKRQLLAE 390
            +       R+ L+E
Sbjct: 361 PRDLRSSSPRKQLSE 375



 Score = 31.2 bits (69), Expect = 6.9
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)

Query: 1022 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1081
            +LL+G E G+ +L+R+ Q     ++   R   +  +   NVL+++SGK   L  + +  L
Sbjct: 513  HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570

Query: 1082 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1128
              R        I H  P      K      + D +GC    V +       FL  AL+ +
Sbjct: 571  LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630

Query: 1129 VEIYAWAPKPYHKFM 1143
            V +  W  +P +KF+
Sbjct: 631  VVLLQWY-QPMNKFL 644


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.374 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,732,606
Number of Sequences: 37866
Number of extensions: 2857831
Number of successful extensions: 70143
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1603
Number of HSP's successfully gapped in prelim test: 1730
Number of HSP's that attempted gapping in prelim test: 18515
Number of HSP's gapped (non-prelim): 19994
length of query: 1323
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1209
effective length of database: 13,930,794
effective search space: 16842329946
effective search space used: 16842329946
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.