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Search of human proteins with 239735582
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
(1331 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 2669 0.0
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 2653 0.0
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 2646 0.0
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 2630 0.0
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 2510 0.0
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 2494 0.0
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 2487 0.0
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 2472 0.0
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 1682 0.0
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 1665 0.0
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 1651 0.0
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 1642 0.0
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 1630 0.0
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 1556 0.0
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 1451 0.0
gi|118600963 Nik related kinase [Homo sapiens] 409 e-113
gi|145275208 myosin IIIA [Homo sapiens] 306 7e-83
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 296 9e-80
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 296 9e-80
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 273 8e-73
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 266 1e-70
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 263 8e-70
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 263 8e-70
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 260 5e-69
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 259 9e-69
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 259 2e-68
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 253 7e-67
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 253 7e-67
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 249 9e-66
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 244 3e-64
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 2669 bits (6917), Expect = 0.0
Identities = 1331/1331 (100%), Positives = 1331/1331 (100%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
Query: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE
Sbjct: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
Query: 541 SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 541 SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
Query: 601 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 601 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
Query: 661 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 661 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
Query: 721 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK 780
SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK
Sbjct: 721 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK 780
Query: 781 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 840
ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP
Sbjct: 781 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 840
Query: 841 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 900
GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL
Sbjct: 841 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 900
Query: 901 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 960
PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE
Sbjct: 901 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 960
Query: 961 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1020
DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE
Sbjct: 961 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1020
Query: 1021 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1080
ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK
Sbjct: 1021 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1080
Query: 1081 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1140
LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY
Sbjct: 1081 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1140
Query: 1141 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1200
AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY
Sbjct: 1141 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1200
Query: 1201 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1260
IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI
Sbjct: 1201 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1260
Query: 1261 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1320
HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF
Sbjct: 1261 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1320
Query: 1321 MTLNRNSMMNW 1331
MTLNRNSMMNW
Sbjct: 1321 MTLNRNSMMNW 1331
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 2653 bits (6877), Expect = 0.0
Identities = 1331/1360 (97%), Positives = 1331/1360 (97%), Gaps = 29/1360 (2%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
REQRRHYEEQMRREEERRRAEHEQEY KRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
Query: 512 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 571
SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
Sbjct: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
Query: 572 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 631
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
Query: 632 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 691
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
Query: 692 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 751
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
Query: 752 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 811
PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 781 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 840
Query: 812 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 871
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 841 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 900
Query: 872 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 931
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 901 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 960
Query: 932 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 991
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 961 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 1020
Query: 992 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1051
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 1021 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1080
Query: 1052 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1111
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1081 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1140
Query: 1112 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1171
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1141 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1200
Query: 1172 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1231
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1201 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1260
Query: 1232 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1291
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1261 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1320
Query: 1292 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1331
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1321 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1360
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 2646 bits (6858), Expect = 0.0
Identities = 1323/1331 (99%), Positives = 1323/1331 (99%), Gaps = 8/1331 (0%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
Query: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE
Sbjct: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
Query: 541 SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 541 SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
Query: 601 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 601 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
Query: 661 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 661 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
Query: 721 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK 780
SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA DLTALAK
Sbjct: 721 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA--------DLTALAK 772
Query: 781 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 840
ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP
Sbjct: 773 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 832
Query: 841 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 900
GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL
Sbjct: 833 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 892
Query: 901 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 960
PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE
Sbjct: 893 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 952
Query: 961 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1020
DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE
Sbjct: 953 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1012
Query: 1021 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1080
ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK
Sbjct: 1013 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1072
Query: 1081 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1140
LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY
Sbjct: 1073 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1132
Query: 1141 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1200
AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY
Sbjct: 1133 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1192
Query: 1201 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1260
IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI
Sbjct: 1193 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1252
Query: 1261 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1320
HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF
Sbjct: 1253 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1312
Query: 1321 MTLNRNSMMNW 1331
MTLNRNSMMNW
Sbjct: 1313 MTLNRNSMMNW 1323
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 2630 bits (6818), Expect = 0.0
Identities = 1323/1360 (97%), Positives = 1323/1360 (97%), Gaps = 37/1360 (2%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
REQRRHYEEQMRREEERRRAEHEQEY KRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 540
Query: 512 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 571
SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS
Sbjct: 541 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 600
Query: 572 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 631
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 601 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 660
Query: 632 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 691
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 661 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 720
Query: 692 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 751
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 721 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 780
Query: 752 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 811
PEESRDITRPSRPA DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 781 PEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 832
Query: 812 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 871
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 833 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 892
Query: 872 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 931
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 893 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 952
Query: 932 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 991
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 953 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 1012
Query: 992 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1051
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 1013 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1072
Query: 1052 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1111
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1073 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1132
Query: 1112 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1171
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1133 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1192
Query: 1172 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1231
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1193 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1252
Query: 1232 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1291
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1253 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1312
Query: 1292 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1331
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1313 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 2510 bits (6505), Expect = 0.0
Identities = 1266/1331 (95%), Positives = 1270/1331 (95%), Gaps = 55/1331 (4%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
Query: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
QRPVEKKPLYHYKE
Sbjct: 481 QRPVEKKPLYHYKE---------------------------------------------- 494
Query: 541 SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
G+ P+ P + +IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 495 -----GMSPSEKPAWAK----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 545
Query: 601 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 546 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605
Query: 661 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 606 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 665
Query: 721 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK 780
SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK
Sbjct: 666 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK 725
Query: 781 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 840
ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP
Sbjct: 726 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 785
Query: 841 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 900
GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL
Sbjct: 786 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 845
Query: 901 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 960
PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE
Sbjct: 846 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 905
Query: 961 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1020
DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE
Sbjct: 906 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 965
Query: 1021 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1080
ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK
Sbjct: 966 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1025
Query: 1081 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1140
LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY
Sbjct: 1026 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1085
Query: 1141 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1200
AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY
Sbjct: 1086 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1145
Query: 1201 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1260
IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI
Sbjct: 1146 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1205
Query: 1261 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1320
HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF
Sbjct: 1206 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1265
Query: 1321 MTLNRNSMMNW 1331
MTLNRNSMMNW
Sbjct: 1266 MTLNRNSMMNW 1276
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 2494 bits (6465), Expect = 0.0
Identities = 1266/1360 (93%), Positives = 1270/1360 (93%), Gaps = 84/1360 (6%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
REQRRHYEEQMRREEERRRAEHEQEY KRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE----------------- 523
Query: 512 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 571
G+ P+ P + +IPHLVAVKS
Sbjct: 524 ----------------------------------GMSPSEKPAWAK----EIPHLVAVKS 545
Query: 572 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 631
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 546 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 605
Query: 632 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 691
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 606 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 665
Query: 692 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 751
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 666 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 725
Query: 752 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 811
PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 726 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 785
Query: 812 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 871
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 786 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 845
Query: 872 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 931
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 846 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 905
Query: 932 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 991
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 906 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 965
Query: 992 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1051
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 966 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1025
Query: 1052 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1111
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1026 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1085
Query: 1112 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1171
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1086 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1145
Query: 1172 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1231
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1146 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1205
Query: 1232 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1291
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1206 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1265
Query: 1292 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1331
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1266 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1305
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 2487 bits (6446), Expect = 0.0
Identities = 1258/1331 (94%), Positives = 1262/1331 (94%), Gaps = 63/1331 (4%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQE 480
Query: 481 QRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSE 540
QRPVEKKPLYHYKE
Sbjct: 481 QRPVEKKPLYHYKE---------------------------------------------- 494
Query: 541 SFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 600
G+ P+ P + +IPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT
Sbjct: 495 -----GMSPSEKPAWAK----EIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVT 545
Query: 601 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP
Sbjct: 546 SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 605
Query: 661 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 720
GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG
Sbjct: 606 GNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPG 665
Query: 721 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAK 780
SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA DLTALAK
Sbjct: 666 SQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA--------DLTALAK 717
Query: 781 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 840
ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP
Sbjct: 718 ELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAP 777
Query: 841 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 900
GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL
Sbjct: 778 GSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINL 837
Query: 901 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 960
PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE
Sbjct: 838 PDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDE 897
Query: 961 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 1020
DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE
Sbjct: 898 DEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSE 957
Query: 1021 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1080
ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK
Sbjct: 958 ILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNK 1017
Query: 1081 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1140
LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY
Sbjct: 1018 LRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIY 1077
Query: 1141 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1200
AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY
Sbjct: 1078 AWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIY 1137
Query: 1201 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1260
IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI
Sbjct: 1138 IPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI 1197
Query: 1261 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1320
HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF
Sbjct: 1198 HSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFF 1257
Query: 1321 MTLNRNSMMNW 1331
MTLNRNSMMNW
Sbjct: 1258 MTLNRNSMMNW 1268
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 2472 bits (6406), Expect = 0.0
Identities = 1258/1360 (92%), Positives = 1262/1360 (92%), Gaps = 92/1360 (6%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLA 360
Query: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE
Sbjct: 361 NKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQE 420
Query: 421 REQRRHYEEQMRREEERRRAEHEQEY-----------------------------KRKQL 451
REQRRHYEEQMRREEERRRAEHEQEY KRKQL
Sbjct: 421 REQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQL 480
Query: 452 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEER 511
EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE
Sbjct: 481 EEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKE----------------- 523
Query: 512 SRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKS 571
G+ P+ P + +IPHLVAVKS
Sbjct: 524 ----------------------------------GMSPSEKPAWAK----EIPHLVAVKS 545
Query: 572 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 631
QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS
Sbjct: 546 QGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSS 605
Query: 632 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 691
WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES
Sbjct: 606 WLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILES 665
Query: 692 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 751
PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK
Sbjct: 666 PLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVK 725
Query: 752 PEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 811
PEESRDITRPSRPA DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE
Sbjct: 726 PEESRDITRPSRPA--------DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSE 777
Query: 812 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 871
EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE
Sbjct: 778 EEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISRE 837
Query: 872 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 931
GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG
Sbjct: 838 GTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSG 897
Query: 932 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 991
TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI
Sbjct: 898 TEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKI 957
Query: 992 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1051
SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY
Sbjct: 958 SVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY 1017
Query: 1052 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1111
NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD
Sbjct: 1018 NLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGD 1077
Query: 1112 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1171
LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE
Sbjct: 1078 LEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVE 1137
Query: 1172 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1231
EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED
Sbjct: 1138 EGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYED 1197
Query: 1232 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1291
EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR
Sbjct: 1198 EGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKR 1257
Query: 1292 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1331
AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
Sbjct: 1258 AQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1297
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 1682 bits (4357), Expect = 0.0
Identities = 905/1370 (66%), Positives = 1043/1370 (76%), Gaps = 106/1370 (7%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+EVEER+R+N+Q +SP
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 525 KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577
K + +P +P S ++TPPM RPV+PQ + H V +K +
Sbjct: 541 KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597
Query: 578 ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 598 RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652
Query: 627 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 686
+ +W+R + + PPKVPQRT+SI+ AL N S G +Q +RASNPDLRR++
Sbjct: 653 -NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSD 704
Query: 687 PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 746
P E S S P+S G P QAGS ER RV +SK + SPVL
Sbjct: 705 PGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-P 746
Query: 747 PAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEE 806
K KP++ R +RP RPASYK+AI ED L +E ++E RP KK DYSSSSEE
Sbjct: 747 GNKAKPDDHR--SRPGRPASYKRAIGEDFVLL----KERTLDEAPRPPKKAMDYSSSSEE 800
Query: 807 SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSF 864
ESSE++EE+GE +G+ D P G + +V + H +E T +
Sbjct: 801 VESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPY 852
Query: 865 SGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTH 924
G GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S
Sbjct: 853 GG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPP 900
Query: 925 SQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQE 981
S++ SG G + K+SFT FVD +YQ + + AL E R +
Sbjct: 901 SKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLD 954
Query: 982 QAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML 1041
Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML
Sbjct: 955 QLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML 1013
Query: 1042 LDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVE 1101
LDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVE
Sbjct: 1014 LDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVE 1073
Query: 1102 KKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQH 1161
KKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H
Sbjct: 1074 KKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPH 1133
Query: 1162 KPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTD 1221
+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TD
Sbjct: 1134 RPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTD 1193
Query: 1222 GMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETG 1281
GMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETG
Sbjct: 1194 GMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETG 1253
Query: 1282 HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1331
HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1254 HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1303
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 1665 bits (4313), Expect = 0.0
Identities = 898/1370 (65%), Positives = 1036/1370 (75%), Gaps = 114/1370 (8%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+EVEER+R+N+Q +SP
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 525 KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577
K + +P +P S ++TPPM RPV+PQ + H V +K +
Sbjct: 541 KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597
Query: 578 ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 598 RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652
Query: 627 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTE 686
+ +W+R + + PPKVPQRT+SI+ AL N S G +Q +RASNPDLRR++
Sbjct: 653 -NPPAWVRPDNEAPPKVPQRTSSIATAL-------NTSGAGGSRPAQAVRASNPDLRRSD 704
Query: 687 PILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHE 746
P E S S P+S G P QAGS ER RV +SK + SPVL
Sbjct: 705 PGWER----------SDSVLPASH-----GHLP--QAGSLERNRVGVSSKPDSSPVLS-P 746
Query: 747 PAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEE 806
K KP++ R +RP RPA + L+E ++E RP KK DYSSSSEE
Sbjct: 747 GNKAKPDDHR--SRPGRPADFVL------------LKERTLDEAPRPPKKAMDYSSSSEE 792
Query: 807 SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLE--TSHADSF 864
ESSE++EE+GE +G+ D P G + +V + H +E T +
Sbjct: 793 VESSEDDEEEGEGGPAEGS---RDTP-----GGRSDGDTDSVSTMVVHDVEEITGTQPPY 844
Query: 865 SGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTH 924
G GT++++ T E++ H+DSNG+ NLPD+VQ SHSP TE S
Sbjct: 845 GG-----GTMVVQRTPEEERNLLHADSNGYT---NLPDVVQPSHSP----TENSKGQSPP 892
Query: 925 SQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQE 981
S++ SG G + K+SFT FVD +YQ + + AL E R +
Sbjct: 893 SKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDS-----IPITALVGGEGTRLD 946
Query: 982 QAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML 1041
Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML
Sbjct: 947 QLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML 1005
Query: 1042 LDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVE 1101
LDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+NKLRVYYLSWLRN+ILHNDPEVE
Sbjct: 1006 LDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVE 1065
Query: 1102 KKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQH 1161
KKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSFADL H
Sbjct: 1066 KKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPH 1125
Query: 1162 KPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTD 1221
+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYDIYIP HIQ ITPHAI+ LP TD
Sbjct: 1126 RPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTD 1185
Query: 1222 GMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETG 1281
GMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVAYI SNQIMGWGEKAIEIRSVETG
Sbjct: 1186 GMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETG 1245
Query: 1282 HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1331
HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTLNRN +MNW
Sbjct: 1246 HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1295
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 1651 bits (4275), Expect = 0.0
Identities = 898/1400 (64%), Positives = 1037/1400 (74%), Gaps = 137/1400 (9%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+EVEER+R+N+Q +SP
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 525 KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQ-------IPHLVAVKSQGPALT 577
K + +P +P S ++TPPM RPV+PQ + H V +K +
Sbjct: 541 KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVP 597
Query: 578 ASQSVHEQPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEK 626
SQS+ +QPT+ L+ F + + S R + RQNSDPTSE P P P
Sbjct: 598 RSQSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP----- 652
Query: 627 FDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ--------- 673
+ +W+R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 653 -NPPAWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRA 711
Query: 674 -----------------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGG 716
P +SNPDLRR++P E S S P+S G
Sbjct: 712 ERGTPKPPGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----G 756
Query: 717 SQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLT 776
P QAGS ER RV +SK + SPVL K KP++ R +RP RPA +
Sbjct: 757 HLP--QAGSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVL------- 804
Query: 777 ALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIP 836
L+E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P
Sbjct: 805 -----LKERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP---- 852
Query: 837 TGAPGSNEQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGF 894
G + +V + H +E T + G GT++++ T E++ H+DSNG+
Sbjct: 853 -GGRSDGDTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGY 906
Query: 895 AGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPR 951
NLPD+VQ SHSP TE S S++ SG G + K+SFT FVD
Sbjct: 907 T---NLPDVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLG 958
Query: 952 VYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIR 1011
+YQ + + AL E R +Q + + RK SVVNVNPTN R HS+TPEIR
Sbjct: 959 IYQPGGSGDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIR 1012
Query: 1012 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVL 1071
KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L
Sbjct: 1013 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLL 1072
Query: 1072 VTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVI 1131
+TISGK+NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVI
Sbjct: 1073 ITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVI 1132
Query: 1132 ALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDV 1191
ALK++VE+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DV
Sbjct: 1133 ALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDV 1192
Query: 1192 DSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWG 1251
DSGNSYDIYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWG
Sbjct: 1193 DSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWG 1252
Query: 1252 EMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1311
EMPTSVAYI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
Sbjct: 1253 EMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1312
Query: 1312 SGGSSQVFFMTLNRNSMMNW 1331
SGGSSQV+FMTLNRN +MNW
Sbjct: 1313 SGGSSQVYFMTLNRNCIMNW 1332
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 1642 bits (4252), Expect = 0.0
Identities = 895/1393 (64%), Positives = 1033/1393 (74%), Gaps = 143/1393 (10%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
M +PARSLD+IDLSALRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIKQEINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGSVTDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKE+ IAYICREILRGL+HLH HKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SD+WSLGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF FI++CL+K + RP TEQL+K PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN-DSGEPSSILNLPGESTLRRDFLRLQL 359
QLKDHIDR++KKRGEK+ETEYEYSGSEEE++ + + GEPSSI+N+PGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQ 360
Query: 360 ANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
NK SEAL++QQ +QQQR+ E H + LL +RQ+RIEEQKE+RRR+EEQQRRE+E RK
Sbjct: 361 ENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRK 420
Query: 418 QQEREQRRHYEEQ--MRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQ 475
QE+EQ+R E+ +RREEERR+AE EQEYKRKQLEEQRQ+ERLQRQL+QE YL SLQ
Sbjct: 421 LQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQ 480
Query: 476 HQRQEQR----------PVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQ-SSPAMPH 524
Q+Q+Q+ P ++KPLYHY GM+P++KPAWA+EVEER+R+N+Q +SP
Sbjct: 481 QQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAKS 540
Query: 525 KVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHE 584
K + +P +P S ++TPPM RPV+PQ +GP +S+ +
Sbjct: 541 KPGSTGPEPPIPQASPG---PPGPLSQTPPMQRPVEPQ---------EGP----HKSLQD 584
Query: 585 QPTKGLSGFQEALN----------VTSHRVEMPRQNSDPTSENP-PLPTRIEKFDRSSWL 633
QPT+ L+ F + + S R + RQNSDPTSE P P P + +W+
Sbjct: 585 QPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSP------NPPAWV 638
Query: 634 RQEEDIPPKVPQRTTSISPALARKNSPGNGSALG----PRLGSQ---------------- 673
R + + PPKVPQRT+SI+ AL + G+ A PR S
Sbjct: 639 RPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKP 698
Query: 674 ----------PIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQA 723
P +SNPDLRR++P E S S P+S G P QA
Sbjct: 699 PGPPAQPPGPPNASSNPDLRRSDPGWER----------SDSVLPASH-----GHLP--QA 741
Query: 724 GSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELR 783
GS ER RV +SK + SPVL K KP++ R +RP RPA + L+
Sbjct: 742 GSLERNRVGVSSKPDSSPVLS-PGNKAKPDDHR--SRPGRPADFVL------------LK 786
Query: 784 ELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSN 843
E ++E RP KK DYSSSSEE ESSE++EE+GE +G+ D P G
Sbjct: 787 ERTLDEAPRPPKKAMDYSSSSEEVESSEDDEEEGEGGPAEGS---RDTP-----GGRSDG 838
Query: 844 EQYNVGMVGTHGLE--TSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLP 901
+ +V + H +E T + G GT++++ T E++ H+DSNG+ NLP
Sbjct: 839 DTDSVSTMVVHDVEEITGTQPPYGG-----GTMVVQRTPEEERNLLHADSNGYT---NLP 890
Query: 902 DLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMG---SSTKASFTPFVDPRVYQTSPT 958
D+VQ SHSP TE S S++ SG G + K+SFT FVD +YQ +
Sbjct: 891 DVVQPSHSP----TENSKGQSPPSKD-GSGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGS 945
Query: 959 DEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFN 1018
+ AL E R +Q + + RK SVVNVNPTN R HS+TPEIRKYKKRFN
Sbjct: 946 GDS-----IPITALVGGEGTRLDQLQY-DVRKGSVVNVNPTNTRAHSETPEIRKYKKRFN 999
Query: 1019 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKK 1078
SEILCAALWGVNLLVGTENGLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK+
Sbjct: 1000 SEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKR 1059
Query: 1079 NKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVE 1138
NKLRVYYLSWLRN+ILHNDPEVEKKQGW TVGD+EGC HY+VVKYERIKFLVIALK++VE
Sbjct: 1060 NKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSVE 1119
Query: 1139 IYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYD 1198
+YAWAPKPYHKFMAFKSFADL H+PLLVDLTVEEGQRLKVI+GS GFH +DVDSGNSYD
Sbjct: 1120 VYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYD 1179
Query: 1199 IYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVA 1258
IYIP HIQ ITPHAI+ LP TDGMEML+CYEDEGVYVNTYGRI KDVVLQWGEMPTSVA
Sbjct: 1180 IYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVA 1239
Query: 1259 YIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV 1318
YI SNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV
Sbjct: 1240 YICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV 1299
Query: 1319 FFMTLNRNSMMNW 1331
+FMTLNRN +MNW
Sbjct: 1300 YFMTLNRNCIMNW 1312
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 1630 bits (4220), Expect = 0.0
Identities = 893/1397 (63%), Positives = 1015/1397 (72%), Gaps = 143/1397 (10%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYKRKQLEEQ----- 454
+QQEREQRR +E+ RR EEE+RR E EQEY R+QLEE+
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 455 ------------------------RQAERLQRQLKQERDYLVSLQHQRQEQRP------- 483
RQAERLQRQL+QE+ YL+SLQH + P
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
Query: 484 ----VEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRS 539
KP +H E + E A+EVE+R R SSP K R+ +P +P RS
Sbjct: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
Query: 540 ESFSISGVQPARTPPMLRPVDPQI--PHLVAVKSQGPALTASQSVHEQPTKGLSGFQEAL 597
ESFS +G + P + RP +PQ+ HL ++K+ ++ S S + K +
Sbjct: 601 ESFS-NGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQ 659
Query: 598 N-VTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEED-IPPKVPQRTTSISPALA 655
+ R E+ Q+SD SE P PT + +W R + D +PP+VP RTTS SP L+
Sbjct: 660 DPCPPSRSEVLSQSSDSKSEAPD-PT------QKAWSRSDSDEVPPRVPVRTTSRSPVLS 712
Query: 656 RKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQG 715
R++SP GS Q S+ + R +E + R SGSSS SS SQP
Sbjct: 713 RRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP---- 768
Query: 716 GSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDL 775
GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA + DL
Sbjct: 769 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG-----EVDL 823
Query: 776 TALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLI 835
TALAKELR + E RP KVTDYSSSSEES +++EE++D E E D + + + R
Sbjct: 824 TALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA 880
Query: 836 PTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET-SGEKKRSGHSDSNGF 894
+ + E +V + H S + + S+EGTL++R+T S H S+ F
Sbjct: 881 SSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASSTLQKHKSSSSF 937
Query: 895 AGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQ 954
I+ P L+Q S S T T +G
Sbjct: 938 TPFID-PRLLQISPSSGTTVTSVVG----------------------------------- 961
Query: 955 TSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYK 1014
F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYK
Sbjct: 962 ------------------FSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYK 1003
Query: 1015 KRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTI 1074
KRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTI
Sbjct: 1004 KRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTI 1063
Query: 1075 SGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALK 1134
SGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK
Sbjct: 1064 SGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALK 1123
Query: 1135 NAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSG 1194
++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG
Sbjct: 1124 SSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSG 1183
Query: 1195 NSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMP 1254
+ YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMP
Sbjct: 1184 SVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMP 1243
Query: 1255 TSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGG 1314
TSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGG
Sbjct: 1244 TSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGG 1303
Query: 1315 SSQVFFMTLNRNSMMNW 1331
SSQV+FMTL R S+++W
Sbjct: 1304 SSQVYFMTLGRTSLLSW 1320
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 1556 bits (4029), Expect = 0.0
Identities = 853/1346 (63%), Positives = 970/1346 (72%), Gaps = 149/1346 (11%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
+QQEREQRR +E+ RR EE R E+E +R+ EE+R+ ER ++RQL++E+ +L
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISD 532
LQ Q +++ A + + R + Q S P
Sbjct: 481 VLQQQLLQEQ----------------------AMLLHDHRRPHPQHSQQPP--------- 509
Query: 533 PNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSG 592
PP+ E R+ P +P+ H +P
Sbjct: 510 ---PPQQE----------RSKPSFHAPEPK-------------------AHYEPADRARE 537
Query: 593 FQEALNVTSHRVEMPRQNSDPTSE--NPPLPTRIEKFDR----SSWLRQEEDIPPKVPQR 646
++ T+H P S T PP+P+R E F S + P+VP R
Sbjct: 538 VEDRFRKTNH--SSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVR 595
Query: 647 TTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSST 706
TTS SP L+R++SP GS Q S+ + R +E + R SGSSS SS
Sbjct: 596 TTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSN 655
Query: 707 PSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPAS 766
SQP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA
Sbjct: 656 SGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG 711
Query: 767 YKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTV 826
+ DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E D +
Sbjct: 712 -----EVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADEST 763
Query: 827 AVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRET-SGEKKR 885
+ + R + + E +V + H S + + S+EGTL++R+T S
Sbjct: 764 SGPEDTRAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASSTL 820
Query: 886 SGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFT 945
H S+ F I+ P L+Q S S T T +G
Sbjct: 821 QKHKSSSSFTPFID-PRLLQISPSSGTTVTSVVG-------------------------- 853
Query: 946 PFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHS 1005
F+ + +R E + + RK SVVNVNPTN RP S
Sbjct: 854 ---------------------------FSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQS 886
Query: 1006 DTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVL 1065
DTPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVL
Sbjct: 887 DTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVL 946
Query: 1066 EGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYER 1125
EGLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYER
Sbjct: 947 EGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYER 1006
Query: 1126 IKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTG 1185
IKFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS G
Sbjct: 1007 IKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAG 1066
Query: 1186 FHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKD 1245
FH +DVDSG+ YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKD
Sbjct: 1067 FHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKD 1126
Query: 1246 VVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1305
VVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV
Sbjct: 1127 VVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV 1186
Query: 1306 FFASVRSGGSSQVFFMTLNRNSMMNW 1331
FFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1187 FFASVRSGGSSQVYFMTLGRTSLLSW 1212
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 1451 bits (3757), Expect = 0.0
Identities = 821/1348 (60%), Positives = 934/1348 (69%), Gaps = 199/1348 (14%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 359 LANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQ 418
NKERSEALRRQQL L+EQQ RE+E K+
Sbjct: 361 QENKERSEALRRQQL-------------------------------LQEQQLREQEEYKR 389
Query: 419 QEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQR 478
Q +R+ EQ + E+RRR E +Q R++ E +RQ ER QR+ +QE
Sbjct: 390 QLLAERQKRIEQQK--EQRRRLEEQQ---RREREARRQQEREQRRREQE----------- 433
Query: 479 QEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPR 538
E+R +E E KE EER R + R+ R
Sbjct: 434 -EKRRLE--------------ELERRRKEEEERRRAEEEK---------RRVE------R 463
Query: 539 SESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSV----HEQPTKGLSGFQ 594
+ + + R ++ + HL ++ Q L Q++ H +P
Sbjct: 464 EQEY------------IRRQLEEEQRHLEVLQQQ---LLQEQAMLLHDHRRPHP------ 502
Query: 595 EALNVTSHRVEMP---RQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSIS 651
H + P ++ S P+ P E DR+ +VP RTTS S
Sbjct: 503 ------QHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAR----------EVPVRTTSRS 546
Query: 652 PALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQP 711
P L+R++SP GS Q S+ + R +E + R SGSSS SS SQP
Sbjct: 547 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP 606
Query: 712 SSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAI 771
GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA
Sbjct: 607 ----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG----- 657
Query: 772 DEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDI 831
+ DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E
Sbjct: 658 EVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQE----------- 703
Query: 832 PRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDS 891
G++E T G E + A S L ET K H D
Sbjct: 704 ---------GADES-------TSGPEDTRAASSLN-------LSNGETESVKTMIVHDDV 740
Query: 892 NGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPR 951
PA TP++ + +Q S + SS SFTPF+DPR
Sbjct: 741 ES---------------EPAMTPSKEGTLIVRQTQSASSTLQKHKSSS---SFTPFIDPR 782
Query: 952 VYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIR 1011
+ Q SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIR
Sbjct: 783 LLQISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIR 838
Query: 1012 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVL 1071
KYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVL
Sbjct: 839 KYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVL 898
Query: 1072 VTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVI 1131
VTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVI
Sbjct: 899 VTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVI 958
Query: 1132 ALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDV 1191
ALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DV
Sbjct: 959 ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV 1018
Query: 1192 DSGNSYDIYIPSHIQGN--------ITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRIT 1243
DSG+ YDIY+P+H++ N I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRIT
Sbjct: 1019 DSGSVYDIYLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRIT 1078
Query: 1244 KDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND 1303
KDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND
Sbjct: 1079 KDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERND 1138
Query: 1304 KVFFASVRSGGSSQVFFMTLNRNSMMNW 1331
KVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1139 KVFFASVRSGGSSQVYFMTLGRTSLLSW 1166
>gi|118600963 Nik related kinase [Homo sapiens]
Length = 1582
Score = 409 bits (1050), Expect = e-113
Identities = 268/717 (37%), Positives = 386/717 (53%), Gaps = 73/717 (10%)
Query: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT- 59
MA R + DL L DP GIF L + +G GTYG++Y G H KTG A+KVM+
Sbjct: 1 MAGPGGWRDREVTDLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARK 60
Query: 60 -----------------------GDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPG 96
DEEE+++ E+N+L+KYS H+NI ++YGAF K +PPG
Sbjct: 61 TPLPEIGRRVRVNKYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPG 120
Query: 97 MDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKG 156
QLW+VME C AGSVTD+++ T +LKE+WIAYICREIL+GL+HLH H+VIHRDIKG
Sbjct: 121 QRHQLWMVMELCAAGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKG 180
Query: 157 QNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDL 216
QNVLLT NAEVKLVDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P +YD++SD+
Sbjct: 181 QNVLLTHNAEVKLVDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDV 240
Query: 217 WSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQ 276
WS+GITAIEMAEGAPPLC++ P+ ALF+I R AP +KS WS+KF +F+E C +KN
Sbjct: 241 WSVGITAIEMAEGAPPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLF 300
Query: 277 RPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDET---EYEYSGSEEEEEEN 333
RP + +++HPF+RD NER V L H+ KKR +K E E + E+
Sbjct: 301 RPTSANMLQHPFVRDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRR 360
Query: 334 DSGEPS---SILNLPGESTLRRDFLRL---------QLANKERSEALRRQQLEQQQRENE 381
G PS +L LP S R LR+ L ++E + QQL+ R
Sbjct: 361 FRG-PSCTHELLRLPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAAR--V 415
Query: 382 EHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAE 441
Q L K ++ Q + +RL+ R L+ Q + + + + Q++ RRA
Sbjct: 416 FMPLQALDSAPKPLKGQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAA 475
Query: 442 ------HEQEYKRKQLEEQRQA---ERLQRQLKQERDY-LVSLQHQRQEQRPVEKKPLYH 491
Q + L+ Q Q ++ Q Q + +D V + Q Q+Q P ++
Sbjct: 476 RVLMPLQAQVRAPRLLQVQSQVSKKQQAQTQTSEPQDLDQVPEEFQGQDQVPEQQ----- 530
Query: 492 YKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNL------PPRSESFSIS 545
++G +P ++ + E+ L + +P P +V + ++P P S +
Sbjct: 531 -RQGQAPEQQQRHNQVPEQ--ELEQNQAPEQP-EVQEQAAEPAQAETEAEEPESLRVNAQ 586
Query: 546 GVQP--ARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHR 603
P ++ +L P+ L+ V+ Q +Q+ +P + + Q + S R
Sbjct: 587 VFLPLLSQDHHVLLPLHLDTQVLIPVEGQTEGSPQAQAWTLEPPQAIGSVQALIEGLS-R 645
Query: 604 VEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSP 660
+ NS+ + PL T +E + + Q E K + +++ ALA++ SP
Sbjct: 646 DLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREK-KSKVSTLRQALAKRLSP 701
Score = 274 bits (701), Expect = 4e-73
Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 58/416 (13%)
Query: 968 SAAALFTSELLRQEQAKLNEA--RKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAA 1025
SA A F S +L ++ E ++ S VNVNP + P P I Y+K F SEI C +
Sbjct: 1157 SADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEFTSEICCGS 1216
Query: 1026 LWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYY 1085
LWGVNLL+GT + L L+DRSG+ + LI RR F+Q+ VLE LN+L+TISG KN+LRVY+
Sbjct: 1217 LWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGHKNRLRVYH 1276
Query: 1086 LSWLRNRILHNDPEVEKKQGWI--------TVGDLEGCIHYKVVKYERIKFLVIALKNAV 1137
L+WLRN+IL+NDPE +++Q + + L GC H+ V+++E ++ IALK+++
Sbjct: 1277 LTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYIAIALKSSI 1336
Query: 1138 EIYAWAPK---------------------------------------PYHKF-------- 1150
+YAWAPK P ++F
Sbjct: 1337 HLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRFKRPDELLH 1396
Query: 1151 -MAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNI 1209
+ K F L HKP+ VDL + +RLK+ F S G+H+ID +S D+ +P + I
Sbjct: 1397 LLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTLPKNPLEII 1456
Query: 1210 TPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWG 1269
P I+ILP G+ M++ + E + V ++ K ++ W ++P+S+A+ + + GWG
Sbjct: 1457 IPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFECTQRTTGWG 1516
Query: 1270 EKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNR 1325
+KAIE+RS+++ L+ + ++L+FLC R DK+FF S S+V+FMTL +
Sbjct: 1517 QKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFMTLGK 1572
Score = 40.8 bits (94), Expect = 0.009
Identities = 41/190 (21%), Positives = 81/190 (42%), Gaps = 21/190 (11%)
Query: 350 LRRDFLRLQLANKERS--------EALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQ 401
L RD LR +N + E L + Q + E K ++ RQ + +
Sbjct: 643 LSRDLLRAPNSNNSKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLSPK 702
Query: 402 RRRLEEQQRREK----ELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQA 457
R R + R EK +L +++R QRR + + EEE R+ + ++E + +E +
Sbjct: 703 RFRAKSSWRPEKLELSDLEARRQRRQRRWEDIFNQHEEELRQVDKDKEDESSDNDEVFHS 762
Query: 458 ERLQRQLKQERDYLVSLQ----HQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK-----EV 508
+ + Q++ + Y+ + + +R P + +H K S ++ + ++
Sbjct: 763 IQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQDHAHHVKFSSSVPQRSLLEQAQKPIDI 822
Query: 509 EERSRLNRQS 518
+RS NRQ+
Sbjct: 823 RQRSSQNRQN 832
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 306 bits (785), Expect = 7e-83
Identities = 155/311 (49%), Positives = 207/311 (66%), Gaps = 11/311 (3%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHH 79
DP+ +E+ E +G GTYG+V+K + K GQ AA+K++D D +EEI+ E N+LK S H
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 80 RNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN--TKGNTLKEEWIAYICREI 137
N+ +YG + KK+ D+LWLV+E C GSVTDL+K +G + E IAYI E
Sbjct: 76 PNVVRFYGIYFKKDKVN-GDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L GL HLH +K IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVIAC++ D TYD + D WSLGITAIE+ +G PPL D+HPMRALF IPRNP P+L+ +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254
Query: 258 -WSKKFQSFIESCLVKNHSQRPATEQLMKHPFI-----RDQPNERQVR--IQLKDHIDRT 309
WS +F FI CL K++ +RP +L++H FI +D ++Q+ I + + T
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEFIGIHQCMGGT 314
Query: 310 KKKRGEKDETE 320
+K R E+ T+
Sbjct: 315 EKARRERIHTK 325
Score = 33.1 bits (74), Expect = 1.8
Identities = 44/211 (20%), Positives = 83/211 (39%), Gaps = 28/211 (13%)
Query: 281 EQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSS 340
E+ +K F P + +KD + + ++ EK+E + EE N ++
Sbjct: 1197 EEEVKQEFYLVGPEVSPKQKSVKDLEENSNLRKVEKEEAMIQSYYQRYTEERNCEESKAA 1256
Query: 341 ILNLPGESTLRRDFLRLQLANKERS------EALRRQQLEQQQRENEEHKRQLLAERQKR 394
L S R + LA E S L ++ + Q E+ K+ + ++
Sbjct: 1257 YLERKAISE-RPSYPVPWLAENETSFKKTLEPTLSQRSIYQNANSMEKEKKTSVVTQRAP 1315
Query: 395 IEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQ 454
I Q+E R RL RH + R+ E +A+ E++ ++ +
Sbjct: 1316 ICSQEEGRGRL-------------------RHETVKERQVEPVTQAQEEEDKAAVFIQSK 1356
Query: 455 RQAERLQRQLKQERDYLVSLQHQRQEQRPVE 485
+ + ++QL+ +D + S +HQR P E
Sbjct: 1357 YRGYKRRQQLR--KDKMSSFKHQRIVTTPTE 1385
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 296 bits (758), Expect = 9e-80
Identities = 152/328 (46%), Positives = 211/328 (64%), Gaps = 11/328 (3%)
Query: 13 IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK--GNTLKEEWI 130
L+ +H N+ +YG F K + + QLWLV+E C GSVT+L+K G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHC-VGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA 250
TP+WMAPEVIAC++ D++YD + D+WSLGITAIE+ +G PPL DMHP++ LF IPRNP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPN-----ERQVRIQLKD 304
P L +KW ++F FI CL+K+ +RP+ L+ HPFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRTKKKRGEKDETEYEYSGSEEEE 330
H + K R E+ T Y + E+
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 296 bits (758), Expect = 9e-80
Identities = 152/328 (46%), Positives = 211/328 (64%), Gaps = 11/328 (3%)
Query: 13 IDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINM 72
+ L +L DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK--GNTLKEEWI 130
L+ +H N+ +YG F K + + QLWLV+E C GSVT+L+K G L E I
Sbjct: 75 LQFLPNHPNVVKFYGMFYKADHC-VGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 131 AYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIG 190
+YI L GL HLH +++IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +G
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVG 193
Query: 191 TPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPA 250
TP+WMAPEVIAC++ D++YD + D+WSLGITAIE+ +G PPL DMHP++ LF IPRNP
Sbjct: 194 TPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPP 253
Query: 251 PR-LKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPN-----ERQVRIQLKD 304
P L +KW ++F FI CL+K+ +RP+ L+ HPFI+ ++Q+ L+D
Sbjct: 254 PTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQD 313
Query: 305 --HIDRTKKKRGEKDETEYEYSGSEEEE 330
H + K R E+ T Y + E+
Sbjct: 314 QKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 273 bits (698), Expect = 8e-73
Identities = 164/417 (39%), Positives = 236/417 (56%), Gaps = 25/417 (5%)
Query: 6 PARSLDEIDLSAL-RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEE 64
P R L ++D +L + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
Query: 65 EIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNT 124
IK+ M + S H + YYG++ K LW+VME+CGAGSV+D+I+ + T
Sbjct: 70 IIKEISIMQQCDSPH--VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
Query: 125 LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
L E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFL 244
RNT IGTP+WMAPEVI + Y+ +D+WSLGITAIEMAEG PP D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 245 IPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLK 303
IP NP P K + WS F F++ CLVK+ QR QL++HPF+R +R +
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
Query: 304 DHIDRTKKKRGEKDETEYEYSGSE-EEEEENDSGEPSSILNLPGE--STLRRDFLRLQLA 360
+ +D K KR E + E + E EE+E DSG +++ G+ T+R A
Sbjct: 296 EAMD-VKLKRQESQQREVDQDDEENSEEDEMDSG---TMVRAVGDEMGTVRVASTMTDGA 351
Query: 361 NK--ERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKEL 415
N E + L Q +E + + R + ++ K EQ+ +E ++
Sbjct: 352 NTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQI 408
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 266 bits (679), Expect = 1e-70
Identities = 141/297 (47%), Positives = 197/297 (66%), Gaps = 15/297 (5%)
Query: 14 DLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINML 73
DLS R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + Q+ ++
Sbjct: 6 DLSR-RNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIM 64
Query: 74 KKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYI 133
K H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+
Sbjct: 65 MKDCKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYV 116
Query: 134 CREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
RE L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPY
Sbjct: 117 SRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY 176
Query: 194 WMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAP 251
WMAPEV A + Y+ DLW++GITAIE+AE PP+ D+HPMRALFL+ ++ P
Sbjct: 177 WMAPEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP 234
Query: 252 RLKSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHID 307
+LK K KWS F F++ L KN +RP E+L++HPF+ Q R + I+L D ++
Sbjct: 235 KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN 290
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 263 bits (672), Expect = 8e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
Query: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
Query: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
Query: 365 SEALRRQQL 373
E R ++
Sbjct: 350 KETEARDEM 358
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 263 bits (672), Expect = 8e-70
Identities = 149/369 (40%), Positives = 224/369 (60%), Gaps = 38/369 (10%)
Query: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKKYS 77
R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + GD+ I+QEI M+K+
Sbjct: 14 RNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECK 73
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T L E IAY+CRE
Sbjct: 74 HC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT--GPLSELQIAYVCRET 124
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL++LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+ +R +FIGTPYWMAP
Sbjct: 125 LQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAP 184
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKS 255
EV A ++N Y+ D+W++GITAIE+ E PP+ D+HPMRALFL+ ++ P+LK
Sbjct: 185 EVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
Query: 256 K-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRG 314
K KWS F +F++ L KN +RP E+L+ H F+ R + ++L D ++
Sbjct: 243 KTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN------- 295
Query: 315 EKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRR----------DFLRLQLANKER 364
+ Y+ E ++D EP +I+ ST R +F +LQ R
Sbjct: 296 -NPDNHAHYT-----EADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLR 349
Query: 365 SEALRRQQL 373
E R ++
Sbjct: 350 KETEARDEM 358
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 260 bits (665), Expect = 5e-69
Identities = 149/338 (44%), Positives = 208/338 (61%), Gaps = 24/338 (7%)
Query: 2 ASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGD 61
A S + L E L+ + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D
Sbjct: 6 APKSKLKKLSEDSLT--KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESD 63
Query: 62 EEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTK 121
+E IK EI+++++ + YYG++ K LW+VME+CGAGSV+D+I+ +
Sbjct: 64 LQEIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LR 114
Query: 122 GNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT 181
TL E+ IA I + L+GL +LH + IHRDIK N+LL KL DFGV+ QL T
Sbjct: 115 NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT 174
Query: 182 VGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRA 241
+ +RNT IGTP+WMAPEVI + Y+ +D+WSLGIT+IEMAEG PP D+HPMRA
Sbjct: 175 MAKRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRA 229
Query: 242 LFLIPRNPAPRL-KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
+F+IP NP P K + WS F F++ CLVKN QR QL++HPFI+ N + V I
Sbjct: 230 IFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI 286
Query: 301 QLKDHIDRT---KKKRGEKDETEYEYSGSEEEEEENDS 335
L+D I K KR E+ + E E +E+E DS
Sbjct: 287 -LRDLITEAMEIKAKRHEEQQRELEEEEENSDEDELDS 323
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 259 bits (663), Expect = 9e-69
Identities = 142/319 (44%), Positives = 202/319 (63%), Gaps = 19/319 (5%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
DP +F ++ +G G++G+VYKG T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
I Y+G+++K +LW++ME+ G GS DL+K L+E +IA I REI
Sbjct: 75 SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH + IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVI + YDFK+D+WSLGITAIE+A+G PP D+HPMR LFLIP+N P L+ +
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
SK F+ F+E+CL K+ RP ++L+KH FI + +L D R K + G +
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRWKSE-GHGE 297
Query: 318 ETEYEYSGSEEEEEENDSG 336
E+ E S + E E+ + G
Sbjct: 298 ESSSEDSDIDGEAEDGEQG 316
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 259 bits (661), Expect = 2e-68
Identities = 141/320 (44%), Positives = 201/320 (62%), Gaps = 18/320 (5%)
Query: 18 LRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKK 75
+ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ DE E+I+QEI +L +
Sbjct: 17 IADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 76
Query: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
+ YYG+++K + +LW++ME+ G GS DL++ E IA + +
Sbjct: 77 CDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATMLK 126
Query: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
EIL+GL +LH K IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WM
Sbjct: 127 EILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWM 186
Query: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS 255
APEVI + YD K+D+WSLGITAIE+A+G PP DMHPMR LFLIP+N P L
Sbjct: 187 APEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG 241
Query: 256 KKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
++K F+ FI++CL K+ S RP ++L+KH FI + +L D R K +
Sbjct: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEGHS 300
Query: 316 KDETEYEYSGSEEEEEENDS 335
DE++ E S SE EN++
Sbjct: 301 DDESDSEGSDSESTSRENNT 320
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 253 bits (647), Expect = 7e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 298
Query: 318 ETEYEYSGSEEEEEEND 334
++ S SE+ + E D
Sbjct: 299 --SHDDSSSEDSDAETD 313
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 253 bits (647), Expect = 7e-67
Identities = 141/317 (44%), Positives = 201/317 (63%), Gaps = 24/317 (7%)
Query: 20 DPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TGDEEEEIKQEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ DE E+I+QEI +L +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 78 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 91 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140
Query: 138 LRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH K IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200
Query: 198 EVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKK 257
EVI + YD K+D+WSLGITAIE+A G PP ++HPM+ LFLIP+N P L+
Sbjct: 201 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 254
Query: 258 WSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKD 317
+SK + F+E+CL K S RP ++L+KH FI + +L IDR K+ + E+
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL---IDRYKRWKAEQ- 310
Query: 318 ETEYEYSGSEEEEEEND 334
++ S SE+ + E D
Sbjct: 311 --SHDDSSSEDSDAETD 325
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 249 bits (637), Expect = 9e-66
Identities = 129/280 (46%), Positives = 184/280 (65%), Gaps = 15/280 (5%)
Query: 17 ALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT-GDEEEEIKQEINMLKK 75
+L+DP FEL++ VG GTYG VYK R T +LAA+K++ + GD+ ++QEI +L++
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
Query: 76 YSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICR 135
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+CR
Sbjct: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
Query: 136 EILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
Query: 196 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRL 253
APEV A + Y+ D+W+LGITAIE+ E PPL +HPMRAL L+ ++ P+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
Query: 254 KSK-KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQ 292
+ K +W++ F F++ L KN +RP E+L++HPF Q
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ 276
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 244 bits (624), Expect = 3e-64
Identities = 141/375 (37%), Positives = 210/375 (56%), Gaps = 13/375 (3%)
Query: 19 RDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH 78
RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ Q+ ++ K
Sbjct: 11 RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
Query: 79 HRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREIL 138
H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E I+Y+CRE+L
Sbjct: 71 HANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQISYVCREVL 122
Query: 139 RGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPE 198
+GL++LH K IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FIGTPYWMAPE
Sbjct: 123 QGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPE 182
Query: 199 VIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRN--PAPRLKSK 256
V A Y+ D+WSLGITAIE+AE PPL D+HP+R LFL+ ++ PRLK K
Sbjct: 183 VAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 240
Query: 257 -KWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGE 315
KWS F +FI+ L K+ +RP+ +++ H + R + + L D + K
Sbjct: 241 GKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSI 300
Query: 316 KDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQ 375
D + E S SS L +P RR +L E +L+
Sbjct: 301 GDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQP 360
Query: 376 QQRENEEHKRQLLAE 390
+ R+ L+E
Sbjct: 361 PRDLRSSSPRKQLSE 375
Score = 31.2 bits (69), Expect = 6.9
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 16/135 (11%)
Query: 1030 NLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWL 1089
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
Query: 1090 RNR--------ILHNDPE---VEKKQGWITVGDLEGCIHYKVVKYERI--KFLVIALKNA 1136
R I H P K + D +GC V + FL AL+ +
Sbjct: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
Query: 1137 VEIYAWAPKPYHKFM 1151
V + W +P +KF+
Sbjct: 631 VVLLQWY-QPMNKFL 644
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,035,568
Number of Sequences: 37866
Number of extensions: 2875041
Number of successful extensions: 70292
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1609
Number of HSP's successfully gapped in prelim test: 1743
Number of HSP's that attempted gapping in prelim test: 18428
Number of HSP's gapped (non-prelim): 20236
length of query: 1331
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1217
effective length of database: 13,930,794
effective search space: 16953776298
effective search space used: 16953776298
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.