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Search of human proteins with 238859541
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo
sapiens]
(503 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 1024 0.0
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 1024 0.0
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 1024 0.0
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 156 5e-38
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 153 4e-37
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 150 3e-36
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 148 1e-35
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 139 5e-33
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 137 2e-32
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 137 3e-32
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 135 7e-32
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 135 1e-31
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 127 3e-29
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 113 4e-25
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 107 2e-23
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 99 7e-21
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 98 2e-20
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 89 7e-18
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 84 3e-16
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 79 1e-14
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 79 1e-14
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 79 1e-14
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 71 2e-12
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 71 2e-12
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 71 2e-12
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 64 2e-10
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 64 4e-10
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 64 4e-10
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 63 7e-10
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 63 7e-10
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 1024 bits (2647), Expect = 0.0
Identities = 503/503 (100%), Positives = 503/503 (100%)
Query: 1 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 60
MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP
Sbjct: 61 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120
Query: 61 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 120
IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL
Sbjct: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180
Query: 121 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 180
EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML
Sbjct: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240
Query: 181 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 240
ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ
Sbjct: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300
Query: 241 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 300
NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL
Sbjct: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360
Query: 301 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 360
WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK
Sbjct: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420
Query: 361 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 420
CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG
Sbjct: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480
Query: 421 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 480
AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR
Sbjct: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540
Query: 481 WTSPQVIKETHKPLGDWSYAYMQ 503
WTSPQVIKETHKPLGDWSYAYMQ
Sbjct: 541 WTSPQVIKETHKPLGDWSYAYMQ 563
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 1024 bits (2647), Expect = 0.0
Identities = 503/503 (100%), Positives = 503/503 (100%)
Query: 1 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 60
MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP
Sbjct: 1 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 60
Query: 61 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 120
IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL
Sbjct: 61 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 120
Query: 121 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 180
EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML
Sbjct: 121 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 180
Query: 181 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 240
ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ
Sbjct: 181 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 240
Query: 241 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 300
NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL
Sbjct: 241 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 300
Query: 301 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 360
WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK
Sbjct: 301 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 360
Query: 361 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 420
CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG
Sbjct: 361 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 420
Query: 421 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 480
AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR
Sbjct: 421 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 480
Query: 481 WTSPQVIKETHKPLGDWSYAYMQ 503
WTSPQVIKETHKPLGDWSYAYMQ
Sbjct: 481 WTSPQVIKETHKPLGDWSYAYMQ 503
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 1024 bits (2647), Expect = 0.0
Identities = 503/503 (100%), Positives = 503/503 (100%)
Query: 1 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 60
MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP
Sbjct: 61 MEAIPCVVGDEEVWTSDVQYQVSPFNHGHKVAKFCYADKSLLNKAIEAALAARKEWDLKP 120
Query: 61 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 120
IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL
Sbjct: 121 IADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVEL 180
Query: 121 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 180
EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML
Sbjct: 181 EGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGNLAGAPALMGNVVLWKPSDTAML 240
Query: 181 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 240
ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ
Sbjct: 241 ASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300
Query: 241 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 300
NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL
Sbjct: 301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSL 360
Query: 301 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 360
WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK
Sbjct: 361 WPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGK 420
Query: 361 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 420
CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG
Sbjct: 421 CDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTG 480
Query: 421 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 480
AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR
Sbjct: 481 AVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILR 540
Query: 481 WTSPQVIKETHKPLGDWSYAYMQ 503
WTSPQVIKETHKPLGDWSYAYMQ
Sbjct: 541 WTSPQVIKETHKPLGDWSYAYMQ 563
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 156 bits (394), Expect = 5e-38
Identities = 137/467 (29%), Positives = 217/467 (46%), Gaps = 32/467 (6%)
Query: 38 DKSLLNKAIEAALAARKE---WDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 94
DK ++KA+EAA A + W R ++ + AD++ R A + A + GK
Sbjct: 67 DKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDR-ATLAALETMDTGKP 125
Query: 95 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 152
+ A I R+ A +A +++G+ ++P N + E G AI+P+NF
Sbjct: 126 FLHAFFIDLEGCIRTLRYFAGWADKIQGK---TIPTDDNVVCFTRHEPIGVCGAITPWNF 182
Query: 153 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 211
+ APAL GN ++ KP++ L + + +++EAG PP ++ VP GP G
Sbjct: 183 PLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGA 242
Query: 212 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 271
++S + I FTGS K L K+ A R+ E GGKN V AD++
Sbjct: 243 AISSHPQINKIAFTGSTEVGK-LVKEAASR----SNLKRVTLELGGKNPCIVCADADLDL 297
Query: 272 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 331
V + F GQ C+A SR++V ++ + R +E + VGDP D T
Sbjct: 298 AVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPF-DVKTEQGPQ 356
Query: 332 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 391
ID K F +I + +E + + GG + G F++P + I KEEIFGP
Sbjct: 357 IDQKQFDKILELIESGKKE-GAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGP 415
Query: 392 VLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 449
V P K+K +++ ++T YGLT AVF+++ D + L +G +IN
Sbjct: 416 -----VQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALE--SGTVWIN-- 466
Query: 450 STGSIVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGD 496
++ Q PFGG + SG N + G + + +T +K LGD
Sbjct: 467 CYNALYAQAPFGGFKMSG-NGRELGEYALAEYTE---VKTVTIKLGD 509
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 153 bits (386), Expect = 4e-37
Identities = 129/444 (29%), Positives = 207/444 (46%), Gaps = 28/444 (6%)
Query: 38 DKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 94
DK ++KA++AA A + W ++R ++ K AD++ R ++M G GK
Sbjct: 56 DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG-GKL 114
Query: 95 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 152
A ++ A I R+ A +A +++G+ ++P N Y E G I P+NF
Sbjct: 115 YSNAYLNDLAGCIKTLRYCAGWADKIQGR---TIPIDGNFFTYTRHEPIGVCGQIIPWNF 171
Query: 153 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 211
+ PAL GN V+ KP++ L + V +++EAG PP ++ VP GP G
Sbjct: 172 PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGA 231
Query: 212 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 271
++S + + FTGS K L K+ A R+ E GGK+ V AD+++
Sbjct: 232 AISSHMDIDKVAFTGSTEVGK-LIKEAAGK----SNLKRVTLELGGKSPCIVLADADLDN 286
Query: 272 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 331
V F + GQ C A SR++V S++ + R +E + +G+P G
Sbjct: 287 AVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP-GVTQGPQ 345
Query: 332 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 391
ID + + +I +E + + GG + GYFV+P + + + I KEEIFGP
Sbjct: 346 IDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-GYFVQPTVFSNVTDEMRIAKEEIFGP 404
Query: 392 VLSVYVYP--DDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 449
V + + DD K + T YGL+ VF++D D + L+ AG ++N
Sbjct: 405 VQQIMKFKSLDDVIKRA-----NNTFYGLSAGVFTKDIDKAITISSALQ--AGTVWVN-- 455
Query: 450 STGSIVGQQPFGGARASGTNDKPG 473
G + Q PFGG + SG + G
Sbjct: 456 CYGVVSAQCPFGGFKMSGNGRELG 479
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 150 bits (379), Expect = 3e-36
Identities = 125/458 (27%), Positives = 220/458 (48%), Gaps = 36/458 (7%)
Query: 28 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 87
G +A F + + +N A++ A AA K W K +R +I L+AA ++ R EI
Sbjct: 61 GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIR-EREDEIATME 119
Query: 88 MVGQGKTVIQA--EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVA 145
+ GK++ +A +ID + + ++++ A A + G+ I +P + R G
Sbjct: 120 CINNGKSIFEARLDIDISWQCLEYY---AGLAASMAGEH-IQLPGGSFGYTRREPLGVCV 175
Query: 146 AISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA 204
I +N+ + APAL GN +++KPS +++ + I EAG+PP + V
Sbjct: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
Query: 205 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 264
G G + + ++FTGSVPT + + A+ + + E GGK+ +
Sbjct: 236 -GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP------VTLELGGKSPLIIF 288
Query: 265 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDF 324
D+ + V G L + F GQ C +R++V + + ++++ RIK+GDP +
Sbjct: 289 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLE- 347
Query: 325 GTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGG--------KCDDSVGYFVEPCIVES 376
T +I+ R+ +++ A+ +L GG K D GY++ PC++ +
Sbjct: 348 DTRMGPLINRPHLERVLGFVKVAKEQ-GAKVLCGGDIYVPEDPKLKD--GYYMRPCVLTN 404
Query: 377 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 436
+KEEIFGPV+S+ + D E L+ + TT +GL VF++D +Q A +V
Sbjct: 405 CRDDMTCVKEEIFGPVMSILSF--DTEAEVLERANDTT-FGLAAGVFTRD---IQRAHRV 458
Query: 437 LRN-AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
+ AG +IN+ + + + PFGG + SG + G
Sbjct: 459 VAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGRENG 494
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 148 bits (374), Expect = 1e-35
Identities = 125/454 (27%), Positives = 217/454 (47%), Gaps = 28/454 (6%)
Query: 28 GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 84
G +V + ADK+ ++KA++AA A W ++R ++ K AD++ R
Sbjct: 63 GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122
Query: 85 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 142
+++ G GK +QA +I FR+ A +A ++ G +++P + + E G
Sbjct: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178
Query: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
I P+NF + APAL GN V+ KP++ L++ + +++EAG PP +I
Sbjct: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINI 238
Query: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
+P GP G + S + I FTGS K + + ++ R+ E GGK+ +
Sbjct: 239 LPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS-----NLKRVTLELGGKSPN 293
Query: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
+ AD++ V + F GQ C+A SR++V S++ + R +E R VG P
Sbjct: 294 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 353
Query: 322 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 381
D T ID K + +I + ++ + + + GGK G+F+EP + +
Sbjct: 354 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 411
Query: 382 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 439
I KEEIFGPV + ++K ++++ + + +GL AVF+ D + + ++
Sbjct: 412 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 465
Query: 440 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
AG +IN ++ Q PFGG + SG + G
Sbjct: 466 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 496
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 139 bits (351), Expect = 5e-33
Identities = 119/454 (26%), Positives = 213/454 (46%), Gaps = 28/454 (6%)
Query: 28 GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 84
G + D++ +++A++AA A + W ++R ++ + AD++ R +
Sbjct: 62 GEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDR-VYLA 120
Query: 85 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 142
+ + GK ++ E+I +R+ A +A + G+ ++P + E G
Sbjct: 121 SLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK---TIPMDGQHFCFTRHEPVG 177
Query: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
I P+NF + APAL GN V+ K ++ L++ + +++EAG PP ++
Sbjct: 178 VCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNI 237
Query: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
+ GP G + + + FTGS HL ++ A + + R+ E GGK+
Sbjct: 238 ITGYGPTAGAAIAQHVDVDKVAFTGSTEV-GHLIQKAAGDSN----LKRVTLELGGKSPS 292
Query: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
V AD+E V + F GQ C A SR +V S++ + R +E+ + KVG+P
Sbjct: 293 IVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPF 352
Query: 322 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 381
E T +D + F R+ +++ + +L GG+ G+F++P +
Sbjct: 353 E-LDTQQGPQVDKEQFERVLGYIQLGQKE-GAKLLCGGERFGERGFFIKPTVFGGVQDDM 410
Query: 382 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 439
I KEEIFGPV ++ K+K+ ++V+ + T YGL AVF++D D T+ L+
Sbjct: 411 RIAKEEIFGPVQPLF-----KFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQ- 464
Query: 440 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
AG ++N + + PFGG + SG + G
Sbjct: 465 -AGTVWVN--TYNIVTCHTPFGGFKESGNGRELG 495
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 137 bits (346), Expect = 2e-32
Identities = 122/454 (26%), Positives = 206/454 (45%), Gaps = 28/454 (6%)
Query: 28 GHKVAKFCYADKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEIL 84
G + + DK ++KA++AA AA + W + R ++ + AD++ R +
Sbjct: 62 GEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDR-TYLA 120
Query: 85 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 142
A + GK + + + ++ R+ A +A + G+ ++P + Y E G
Sbjct: 121 ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGK---TIPIDGDFFSYTRHEPVG 177
Query: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
I P+NF + PAL GNVV+ K ++ L + V +++EAG PP ++
Sbjct: 178 VCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNI 237
Query: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
VP GP G + S E + + FTGS + + QVA R+ E GGK+ +
Sbjct: 238 VPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVI--QVAAGSS---NLKRVTLELGGKSPN 292
Query: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
+ AD++ V + F GQ C A SR +V ++ + R + VG+P
Sbjct: 293 IIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPF 352
Query: 322 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 381
D T +D F +I ++ + + + GG D GYF++P +
Sbjct: 353 -DSKTEQGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR-GYFIQPTVFGDVQDGM 410
Query: 382 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 439
I KEEIFGPV+ + K+K ++V + ++YGL AVF++D D ++ L+
Sbjct: 411 TIAKEEIFGPVMQIL-----KFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQ- 464
Query: 440 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
AG ++N Q PFGG + SG+ + G
Sbjct: 465 -AGTVWVNCYDV--FGAQSPFGGYKMSGSGRELG 495
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 137 bits (344), Expect = 3e-32
Identities = 114/417 (27%), Positives = 199/417 (47%), Gaps = 25/417 (5%)
Query: 62 ADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELE 121
++R ++ K AD++ R +++ G GK +QA +I FR+ A +A ++
Sbjct: 4 SERGRLLDKLADLVERDRAVLATMESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIH 62
Query: 122 GQQPISVPPSTNSTVYRGLE--GFVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTA 178
G +++P + + E G I P+NF + APAL GN V+ KP++
Sbjct: 63 G---MTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQT 119
Query: 179 MLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 238
L++ + +++EAG PP +I +P GP G + S + I FTGS K + +
Sbjct: 120 PLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAA 179
Query: 239 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 298
++ R+ E GGK+ + + AD++ V + F GQ C+A SR++V
Sbjct: 180 GRS-----NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEE 234
Query: 299 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 358
S++ + R +E R VG P D T ID K + +I + ++ + + + G
Sbjct: 235 SIYEEFVRRSVERAKRRVVGSPF-DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECG 292
Query: 359 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSY 416
GK G+F+EP + + I KEEIFGPV + ++K ++++ + + +
Sbjct: 293 GKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDF 347
Query: 417 GLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
GL AVF+ D + + ++ AG +IN ++ Q PFGG + SG + G
Sbjct: 348 GLVAAVFTNDINKALTVSSAMQ--AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 400
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 135 bits (341), Expect = 7e-32
Identities = 114/437 (26%), Positives = 198/437 (45%), Gaps = 24/437 (5%)
Query: 39 KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 98
K + A++AA A W + +R+++ + AD+L A++ QGKT+ A
Sbjct: 44 KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102
Query: 99 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 158
+ FRF A ++ + R G ISP+N
Sbjct: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162
Query: 159 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 217
APA+ GN V+ KPS+ + ++ + ++L +AG+PP ++ V GP G+ + S
Sbjct: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222
Query: 218 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 277
+ I+FTGS PT + + + A + +L+ E GGKN + A+++ + T+
Sbjct: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276
Query: 278 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 337
RS+F G+ C SR++V S++ + R +E + KVG P++ A+I
Sbjct: 277 RSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPL-VSIGALISKAHL 335
Query: 338 ARIKKWLEHARSSPSLTILAGGKCD-------DSVGYFVEPCIVESKDPQEPIMKEEIFG 390
+++ +++ A + I G D + GYF+ P ++ + M EEIFG
Sbjct: 336 EKVRSYVKRALAE-GAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394
Query: 391 PVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKS 450
PV V P D +E ++ ++ YGL V+S + V K L+ +G + N
Sbjct: 395 PV--TCVVPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWL 449
Query: 451 TGSIVGQQPFGGARASG 467
+ PFGG ++SG
Sbjct: 450 IREL--NLPFGGMKSSG 464
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 135 bits (339), Expect = 1e-31
Identities = 111/451 (24%), Positives = 200/451 (44%), Gaps = 29/451 (6%)
Query: 28 GHKVAKFCYADKSLLNKAIEAALAARK--EWDLKPIADRAQIFLKAADMLSGPRRAEILA 85
G + K YA + ++KA+ AA A + EW +R ++ + AD+L + E+
Sbjct: 468 GSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLE-ENQEELAT 526
Query: 86 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PISVPPSTNSTVYRGLE--G 142
+ G A + FR+ A + +++G PI+ + + E G
Sbjct: 527 IEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLG 586
Query: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
A I P+N+ + A L GN ++ KP+ L + + +AG P +I
Sbjct: 587 VCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINI 646
Query: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
+P G + G ++ + + FTGS P K + K A + +++ E GGK+
Sbjct: 647 IPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVS-----NLKKVSLELGGKSPL 701
Query: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
+ +++ V + + F G+ C A RL+V S+ + R++EE ++K+GDP
Sbjct: 702 IIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPL 761
Query: 322 E---DFGTFFSAVIDAKSFARIKKWLEHARS--SPSLTILAGGKCDDSVGYFVEPCIVES 376
+ D G A ++K L++ + T++ GG+ G+F+EP +
Sbjct: 762 DRSTDHG-------PQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTD 814
Query: 377 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 436
+ + KEE FGP++ + + + LQ +S T YGL VF++D + ++
Sbjct: 815 VEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANS-TEYGLASGVFTRDINKAMYVSEK 873
Query: 437 LRNAAGNFYINDKSTGSIVGQQPFGGARASG 467
L AG +IN + + PFGG + SG
Sbjct: 874 LE--AGTVFINTYNKTDVAA--PFGGVKQSG 900
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 127 bits (318), Expect = 3e-29
Identities = 112/446 (25%), Positives = 194/446 (43%), Gaps = 19/446 (4%)
Query: 28 GHKVAKFCYADKSLLNKAIEAALAARKE--WDLKPIADRAQIFLKAADMLSGPRRAEILA 85
G + + A + ++KA+ AA A + W DR ++ + AD++ + E+
Sbjct: 447 GSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLME-QHQEELAT 505
Query: 86 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PIS-VPPSTNSTVYRGLE-G 142
+ G A I FR+ A + +++G PI+ P+ N T+ R G
Sbjct: 506 IEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVG 565
Query: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
I P+N+ + + A L GN V+ KP+ L + + +AG+P ++
Sbjct: 566 VCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNV 625
Query: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
+P G L G ++ + I FTGS KH+ K A +++ E GGK+
Sbjct: 626 LPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCA-----ISNVKKVSLELGGKSPL 680
Query: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
+ D+ V + S F G+ C A RL+V S+ + R++EE ++KVG+P
Sbjct: 681 IIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPL 740
Query: 322 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 381
D T ++ ++ +H T++ GG G+F EP + +
Sbjct: 741 -DRDTDHGPQNHHAHLVKLMEYCQHG-VKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHM 798
Query: 382 PIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAA 441
I KEE FGPV+ + + D L ++ T +GL VF++D + + L+ A
Sbjct: 799 FIAKEESFGPVMIISRFADGDLDAVLSRANA-TEFGLASGVFTRDINKALYVSDKLQ--A 855
Query: 442 GNFYINDKSTGSIVGQQPFGGARASG 467
G ++N + + PFGG + SG
Sbjct: 856 GTVFVNTYNKTDVAA--PFGGFKQSG 879
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 113 bits (283), Expect = 4e-25
Identities = 119/476 (25%), Positives = 205/476 (43%), Gaps = 45/476 (9%)
Query: 20 YQVSPFNHGHKVAKFCYADKSLLNKAIEAALA--------ARKEWDLK---PIADRAQIF 68
Y S G + +C A+ + + +A++A AR+ W + P R +I
Sbjct: 55 YNGSWGGRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIV 114
Query: 69 LKAADMLSGPRRAEILAKTM-VGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPIS 127
+ D L + ++L + + GK +++ + E +D YAV L
Sbjct: 115 RQIGDALR--EKIQVLGSLVSLEMGKILVEG-VGEVQEYVDI----CDYAVGLSRMIGGP 167
Query: 128 VPPSTNSTVYRGLE-----GFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDTAMLA 181
+ PS S + +E G V I+ FNF A+ G + GNV LWK + T L
Sbjct: 168 ILPSERSG-HALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLI 226
Query: 182 SYAVYRILR---EAGLPPNIIQFVPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQV 238
S AV +I+ E P I + G G + E + ++FTGS K + V
Sbjct: 227 SVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMV 286
Query: 239 AQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPH 298
+ F R E GG N AD+ VV L +A GQ+C+ RL++
Sbjct: 287 QER------FGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHE 340
Query: 299 SLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAG 358
S+ ++ RL + +++I+VG+P D + + ++ + +E A+ T++ G
Sbjct: 341 SIHDEVVNRLKKAYAQIRVGNP-WDPNVLYGPLHTKQAVSMFLGAVEEAKKEGG-TVVYG 398
Query: 359 GKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGL 418
GK D G +VEP IV I E F P+L V+ + K +E + ++ GL
Sbjct: 399 GKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKF---KNEEEVFAWNNEVKQGL 455
Query: 419 TGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIV-----GQQPFGGARASGTN 469
+ ++F++D + + G +N ++G+ + G++ GG R SG++
Sbjct: 456 SSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSD 511
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 107 bits (268), Expect = 2e-23
Identities = 111/454 (24%), Positives = 197/454 (43%), Gaps = 66/454 (14%)
Query: 28 GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 84
G +V + ADK+ ++KA++AA A W ++R ++ K AD++ R
Sbjct: 63 GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122
Query: 85 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 142
+++ G GK +QA +I FR+ A +A ++ G +++P + + E G
Sbjct: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178
Query: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
I P+NF + APAL GN V+ KP++ L++ + +++E G
Sbjct: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG-------- 230
Query: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
++ Q R+ E GGK+ +
Sbjct: 231 -----------------------------------KLIQEAAGRSNLKRVTLELGGKSPN 255
Query: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
+ AD++ V + F GQ C+A SR++V S++ + R +E R VG P
Sbjct: 256 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 315
Query: 322 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 381
D T ID K + +I + ++ + + + GGK G+F+EP + +
Sbjct: 316 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 373
Query: 382 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 439
I KEEIFGPV + ++K ++++ + + +GL AVF+ D + + ++
Sbjct: 374 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 427
Query: 440 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
AG +IN ++ Q PFGG + SG + G
Sbjct: 428 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 458
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 99.4 bits (246), Expect = 7e-21
Identities = 106/430 (24%), Positives = 178/430 (41%), Gaps = 64/430 (14%)
Query: 39 KSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQA 98
K + A++AA A W + +R+++ + AD+L A++ QGKT+ A
Sbjct: 44 KDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESK-DQGKTLALA 102
Query: 99 EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIGGN 158
+ FRF A ++ + R G ISP+N
Sbjct: 103 RTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLT 162
Query: 159 LAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTSSE 217
APA+ GN V+ KPS+ + ++ + ++L +AG+PP ++ V GP G+ + S
Sbjct: 163 WKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHP 222
Query: 218 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 277
+ I+FTGS PT + + + A + +L+ E GGKN + A+++ + T+
Sbjct: 223 EVPLISFTGSQPTAERITQLSAPHC------KKLSLELGGKNPAIIFEDANLDECIPATV 276
Query: 278 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSF 337
RS+F + R YV R L E ++I G+ +
Sbjct: 277 RSSF-------ANQVRSYVK---------RALAEGAQIWCGEGVDKL------------- 307
Query: 338 ARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVYV 397
S P+ + GYF+ P ++ + M EEIFGPV V
Sbjct: 308 -----------SLPA---------RNQAGYFMLPTVITDIKDESCCMTEEIFGPV--TCV 345
Query: 398 YPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVGQ 457
P D +E ++ ++ YGL V+S + V K L+ +G + N +
Sbjct: 346 VPFDSEEEVIERANN-VKYGLAATVWSSNVGRVHRVAKKLQ--SGLVWTNCWLIREL--N 400
Query: 458 QPFGGARASG 467
PFGG ++SG
Sbjct: 401 LPFGGMKSSG 410
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 98.2 bits (243), Expect = 2e-20
Identities = 105/431 (24%), Positives = 192/431 (44%), Gaps = 28/431 (6%)
Query: 45 AIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EID 101
A+ AA A W +R+ + K +++ + + LA+ + + GK + +A EI
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNKDDLARIITAESGKPLKEAHGEIL 158
Query: 102 AAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLA 160
+A +++F A+ + G + + V + G A I+P+NF +A+
Sbjct: 159 YSAFFLEWFSEEAR---RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKV 215
Query: 161 GAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA---DGPLFGDTVTSSE 217
GA G V+ KP++ ++ A+ + +AG+P + +P + G+ + +
Sbjct: 216 GAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDP 275
Query: 218 HLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTL 277
+ I+FTGS T K L A ++ R ++ E GG V SA+V+ V+G +
Sbjct: 276 LVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVFDSANVDQAVAGAM 329
Query: 278 RSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSR-IKVGDPAEDFGTFFSAVIDAKS 336
S F GQ C ++ V + E + ++VG+ E+ GT +I+ K+
Sbjct: 330 ASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE-GTTQGPLINEKA 388
Query: 337 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 396
+++K + A S T++ GGK F EP ++ + EE FGP+ V
Sbjct: 389 VEKVEKQVNDA-VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVI 447
Query: 397 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 456
+ D +E + + ++ GL G +SQD + + L G +N+ S+
Sbjct: 448 KF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGMVGVNEGLISSV-- 500
Query: 457 QQPFGGARASG 467
+ PFGG + SG
Sbjct: 501 ECPFGGVKQSG 511
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 89.4 bits (220), Expect = 7e-18
Identities = 105/444 (23%), Positives = 193/444 (43%), Gaps = 41/444 (9%)
Query: 45 AIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EID 101
A+ AA A W +R+ + K +++ + + LA+ + + GK + +A EI
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMI--QNKDDLARIITAESGKPLKEAHGEIL 158
Query: 102 AAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLA 160
+A +++F A+ + G + + V + G A I+P+NF +A+
Sbjct: 159 YSAFFLEWFSEEAR---RVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKV 215
Query: 161 GAPALMGNVVLWKPSDTAMLASYAVYRILR-------------EAGLPPNIIQFVPA--- 204
GA G V+ KP++ ++ A+ + + +AG+P + +P
Sbjct: 216 GAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRK 275
Query: 205 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 264
+ G+ + + + I+FTGS T K L A ++ R ++ E GG V
Sbjct: 276 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKR------VSMELGGLAPFIVF 329
Query: 265 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSR-IKVGDPAED 323
SA+V+ V+G + S F GQ C ++ V + E + ++VG+ E+
Sbjct: 330 DSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEE 389
Query: 324 FGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPI 383
GT +I+ K+ +++K + A S T++ GGK F EP ++ +
Sbjct: 390 -GTTQGPLINEKAVEKVEKQVNDA-VSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLC 447
Query: 384 MKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGN 443
EE FGP+ V + D +E + + ++ GL G +SQD + + L G
Sbjct: 448 THEETFGPLAPVIKF--DTEEEAIAIANA-ADVGLAGYFYSQDPAQIWRVAEQLE--VGM 502
Query: 444 FYINDKSTGSIVGQQPFGGARASG 467
+N+ S+ + PFGG + SG
Sbjct: 503 VGVNEGLISSV--ECPFGGVKQSG 524
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 84.0 bits (206), Expect = 3e-16
Identities = 97/396 (24%), Positives = 169/396 (42%), Gaps = 26/396 (6%)
Query: 37 ADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVI 96
A K+ ++ AI + A W + R Q+ L+ ++ + EI + QGKT+
Sbjct: 74 ATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLK-EIAKLITLEQGKTLA 132
Query: 97 QAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNFTAIG 156
AE D L + G+ S+ + YR G A I+PFNF A+
Sbjct: 133 DAEGDVFRGL-QVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191
Query: 157 GNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTS 215
A++ GN L KPS+ A+ + ++L+++G P + + + +
Sbjct: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAV-NFICD 250
Query: 216 SEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSG 275
+ I+F GS ++++++ +++ R+ G KN V A+ E+ ++
Sbjct: 251 HPDIKAISFVGSNKAGEYIFERGSRH------GKRVQANMGAKNHGVVMPDANKENTLNQ 304
Query: 276 TLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS---RIKVGD-PAEDFGTFFSAV 331
+ +AF GQ+C A S + + L EH+ R+ GD P D G +
Sbjct: 305 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPE--LVEHAKNLRVNAGDQPGADLGP----L 358
Query: 332 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSV---GYFVEPCIVESKDPQEPIMKEEI 388
I ++ R+ ++ + +L G K G FV P I+ + P KEEI
Sbjct: 359 ITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEI 418
Query: 389 FGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFS 424
FGPVL V + E +Q+V++ YG A+F+
Sbjct: 419 FGPVL--VVLETETLDEAIQIVNN-NPYGNGTAIFT 451
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 78.6 bits (192), Expect = 1e-14
Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)
Query: 40 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 99
S +++A++ A AA +P+ R Q L+A L + E++ K A
Sbjct: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 100 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 152
+ +++ + + E +P+ P T ++ G V I PFN
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 153 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 209
T + GA A GN V+ KPS+ + + + I+ + L P I VP L
Sbjct: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
Query: 210 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 269
E I +TGS K + A++L + E GGK+ +V ++ D+
Sbjct: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225
Query: 270 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 327
+ F GQ C A + S+ QI +L + D + D+G
Sbjct: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284
Query: 328 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 387
+I A+ F R+ +E + +A G D+ ++ P I+ DPQ P+M+EE
Sbjct: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334
Query: 388 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 447
IFGPVL + +E +Q ++ L +FS + V+++ + ++G N
Sbjct: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389
Query: 448 DKSTGSIVGQQPFGGARASGTNDKPG 473
D + PFGG SG G
Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 78.6 bits (192), Expect = 1e-14
Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)
Query: 40 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 99
S +++A++ A AA +P+ R Q L+A L + E++ K A
Sbjct: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 100 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 152
+ +++ + + E +P+ P T ++ G V I PFN
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 153 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 209
T + GA A GN V+ KPS+ + + + I+ + L P I VP L
Sbjct: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
Query: 210 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 269
E I +TGS K + A++L + E GGK+ +V ++ D+
Sbjct: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225
Query: 270 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 327
+ F GQ C A + S+ QI +L + D + D+G
Sbjct: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284
Query: 328 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 387
+I A+ F R+ +E + +A G D+ ++ P I+ DPQ P+M+EE
Sbjct: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334
Query: 388 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 447
IFGPVL + +E +Q ++ L +FS + V+++ + ++G N
Sbjct: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389
Query: 448 DKSTGSIVGQQPFGGARASGTNDKPG 473
D + PFGG SG G
Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 78.6 bits (192), Expect = 1e-14
Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)
Query: 40 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 99
S +++A++ A AA +P+ R Q L+A L + E++ K A
Sbjct: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 100 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 152
+ +++ + + E +P+ P T ++ G V I PFN
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 153 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 209
T + GA A GN V+ KPS+ + + + I+ + L P I VP L
Sbjct: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
Query: 210 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 269
E I +TGS K + A++L + E GGK+ +V ++ D+
Sbjct: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225
Query: 270 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 327
+ F GQ C A + S+ QI +L + D + D+G
Sbjct: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284
Query: 328 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 387
+I A+ F R+ +E + +A G D+ ++ P I+ DPQ P+M+EE
Sbjct: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334
Query: 388 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 447
IFGPVL + +E +Q ++ L +FS + V+++ + ++G N
Sbjct: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389
Query: 448 DKSTGSIVGQQPFGGARASGTNDKPG 473
D + PFGG SG G
Sbjct: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 71.2 bits (173), Expect = 2e-12
Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)
Query: 142 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 197
G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP
Sbjct: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157
Query: 198 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 253
+ Q V GP +T EH I FTGS K + A++L +
Sbjct: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209
Query: 254 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 313
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269
Query: 314 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 373
R DP +I+ K F R++ L R + GG+ D+S Y + P +
Sbjct: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320
Query: 374 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 433
+ EP+M+EEIFGP+L + E ++ ++ L FS VV+
Sbjct: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377
Query: 434 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 467
+ + ++G F ND + PFGG ASG
Sbjct: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 71.2 bits (173), Expect = 2e-12
Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)
Query: 142 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 197
G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP
Sbjct: 69 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 120
Query: 198 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 253
+ Q V GP +T EH I FTGS K + A++L +
Sbjct: 121 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 172
Query: 254 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 313
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 173 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 232
Query: 314 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 373
R DP +I+ K F R++ L R + GG+ D+S Y + P +
Sbjct: 233 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 283
Query: 374 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 433
+ EP+M+EEIFGP+L + E ++ ++ L FS VV+
Sbjct: 284 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 340
Query: 434 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 467
+ + ++G F ND + PFGG ASG
Sbjct: 341 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 372
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 71.2 bits (173), Expect = 2e-12
Identities = 91/334 (27%), Positives = 139/334 (41%), Gaps = 38/334 (11%)
Query: 142 GFVAAISPFNFTAIGGNLAGAPAL----MGNVVLWKPSDTAMLASYAVYRILREAGLPPN 197
G V I+P+N+ NL P + GN V+ KPS+ S V +IL E LP
Sbjct: 106 GLVLIIAPWNYPL---NLTLVPLVGALAAGNCVVLKPSEI----SKNVEKILAEV-LPQY 157
Query: 198 IIQF---VPADGPLFGDTVTSSEHLCG-INFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 253
+ Q V GP +T EH I FTGS K + A++L +
Sbjct: 158 VDQSCFAVVLGGPQ--ETGQLLEHRFDYIFFTGSPRVGKIVMTAAAKHLTP------VTL 209
Query: 254 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 313
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 210 ELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 269
Query: 314 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 373
R DP +I+ K F R++ L R + GG+ D+S Y + P +
Sbjct: 270 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRY-IAPTV 320
Query: 374 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEA 433
+ EP+M+EEIFGP+L + E ++ ++ L FS VV+
Sbjct: 321 LVDVQEMEPVMQEEIFGPILPIVNV--QSLDEAIEFINRREK-PLALYAFSNSSQVVKRV 377
Query: 434 TKVLRNAAGNFYINDKSTGSIVGQQPFGGARASG 467
+ + ++G F ND + PFGG ASG
Sbjct: 378 --LTQTSSGGFCGNDGFMHMTLASLPFGGVGASG 409
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 64.3 bits (155), Expect = 2e-10
Identities = 115/472 (24%), Positives = 188/472 (39%), Gaps = 64/472 (13%)
Query: 28 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 87
G +A A + A+EAA A K W P RAQ + A+++ +R ++
Sbjct: 65 GENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLES 124
Query: 88 MV-GQG-KTVIQAEIDAAAELIDFFRFNAKYAVE-LEGQQPISVPPSTNSTVYRGLEGFV 144
+V G+ + V ++ A +L+ + A E L G +P+ G +
Sbjct: 125 LVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM---------------GVI 169
Query: 145 AAISP--FNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFV 202
I P F+F + + A A+ VV P A A + ++ E G P I+ +
Sbjct: 170 GLILPPTFSFLEMMWRICPALAVGCTVVALVP--PASPAPLLLAQLAGELGPFPGILNVL 227
Query: 203 PADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGEC------- 255
L + S + + F G+ + L + LAGEC
Sbjct: 228 SGPASLV-PILASQPGIRKVAFCGAPEEGRALRRS-------------LAGECAELGLAL 273
Query: 256 GGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRI 315
G ++ + +ADV+S V G + +A+ G RL + S+W + RL E R+
Sbjct: 274 GTESLLLLTDTADVDSAVEGVVDAAWSDRG---PGGLRLLIQESVWDEAMRRLQERMGRL 330
Query: 316 KVG---DPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPC 372
+ G D A D G +A D +++++ A+S + AG S F P
Sbjct: 331 RSGRGLDGAVDMGARGAAACDL-----VQRFVREAQSQGAQVFQAGDV--PSERPFYPPT 383
Query: 373 IVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQE 432
+V + P P + E+ PV V P KE L LV + T G + +V+S+ E
Sbjct: 384 LVSNLPPASPCAQVEVPWPV--VVASPFRTAKEAL-LVANGTPRGGSASVWSERLGQALE 440
Query: 433 ATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSP 484
L+ G +IN + G P GG + SG + GGP + + P
Sbjct: 441 LGYGLQ--VGTVWIN--AHGLRDPSVPTGGCKESGCS-WHGGPDGLYEYLRP 487
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 63.5 bits (153), Expect = 4e-10
Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%)
Query: 159 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 216
L GA A GN V+ KPS+ + + + ++L P + Q ++ +G + T
Sbjct: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175
Query: 217 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 276
+ I +TG+ K + + A++L + E GGK+ ++ + D++ V
Sbjct: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229
Query: 277 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 336
+ GQ C A + SL QI ++ E G+ ++ + +I+ +
Sbjct: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287
Query: 337 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 396
F RI LE + I GG+ D++ Y + P ++ DP+ +M+EEIFGP+L
Sbjct: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338
Query: 397 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 456
+ P E + ++ L VFS + +++ + ++G ND +
Sbjct: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395
Query: 457 QQPFGGARASG 467
PFGG +SG
Sbjct: 396 SFPFGGVGSSG 406
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 63.5 bits (153), Expect = 4e-10
Identities = 74/311 (23%), Positives = 135/311 (43%), Gaps = 28/311 (9%)
Query: 159 LAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQ--FVPADGPLFGDTVTSS 216
L GA A GN V+ KPS+ + + + ++L P + Q ++ +G + T
Sbjct: 122 LIGAIAA-GNAVIIKPSELSENTAKILAKLL-----PQYLDQDLYIVINGGVEETTELLK 175
Query: 217 EHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGT 276
+ I +TG+ K + + A++L + E GGK+ ++ + D++ V
Sbjct: 176 QRFDHIFYTGNTAVGKIVMEAAAKHLTP------VTLELGGKSPCYIDKDCDLDIVCRRI 229
Query: 277 LRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAKS 336
+ GQ C A + SL QI ++ E G+ ++ + +I+ +
Sbjct: 230 TWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIKE-SPDYERIINLRH 287
Query: 337 FARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSVY 396
F RI LE + I GG+ D++ Y + P ++ DP+ +M+EEIFGP+L
Sbjct: 288 FKRILSLLEGQK------IAFGGETDEATRY-IAPTVLTDVDPKTKVMQEEIFGPILP-- 338
Query: 397 VYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIVG 456
+ P E + ++ L VFS + +++ + ++G ND +
Sbjct: 339 IVPVKNVDEAINFINEREK-PLALYVFSHNHKLIKR--MIDETSSGGVTGNDVIMHFTLN 395
Query: 457 QQPFGGARASG 467
PFGG +SG
Sbjct: 396 SFPFGGVGSSG 406
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 62.8 bits (151), Expect = 7e-10
Identities = 100/381 (26%), Positives = 156/381 (40%), Gaps = 60/381 (15%)
Query: 142 GFVAAISPFNF----TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPN 197
G V I+P+N+ T + L GA A G+ V+ KPS+ S ++L E LP
Sbjct: 25 GLVLIIAPWNYPLNLTLV--LLVGALAA-GSCVVLKPSEI----SQGTEKVLAEV-LPQY 76
Query: 198 IIQF---VPADGPLFGDTVTSSEH-LCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 253
+ Q V GP +T EH L I FTGS K + ++L +
Sbjct: 77 LDQSCFAVVLGGPQ--ETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTP------VTL 128
Query: 254 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 313
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 129 ELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 188
Query: 314 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 373
R DP +I+ K F R++ L R + GG+ ++S Y + P +
Sbjct: 189 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSNESDRY-IAPTV 239
Query: 374 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSY------GLTGAVFSQDK 427
+ EP+M+EEIFGP+L + +Q VD + L FS
Sbjct: 240 LVDVQETEPVMQEEIFGPILPIV---------NVQSVDEAIKFINRQEKPLALYAFSNSS 290
Query: 428 DVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGG------PHY---I 478
VV + + R ++G+F N+ T + PFGG SG G H+ +
Sbjct: 291 QVVNQMLE--RTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCL 348
Query: 479 LRWTSPQVIKETH-KPLGDWS 498
L + + +KE H P DW+
Sbjct: 349 LAPSGLEKLKEIHYPPYTDWN 369
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 62.8 bits (151), Expect = 7e-10
Identities = 100/381 (26%), Positives = 156/381 (40%), Gaps = 60/381 (15%)
Query: 142 GFVAAISPFNF----TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPN 197
G V I+P+N+ T + L GA A G+ V+ KPS+ S ++L E LP
Sbjct: 25 GLVLIIAPWNYPLNLTLV--LLVGALAA-GSCVVLKPSEI----SQGTEKVLAEV-LPQY 76
Query: 198 IIQF---VPADGPLFGDTVTSSEH-LCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAG 253
+ Q V GP +T EH L I FTGS K + ++L +
Sbjct: 77 LDQSCFAVVLGGPQ--ETGQLLEHKLDYIFFTGSPRVGKIVMTAATKHLTP------VTL 128
Query: 254 ECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHS 313
E GGKN +V + D ++V + + GQ C A + + ++ L +
Sbjct: 129 ELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTIT 188
Query: 314 RIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCI 373
R DP +I+ K F R++ L R + GG+ ++S Y + P +
Sbjct: 189 RFYGDDPQSSPN--LGRIINQKQFQRLRALLGCGR------VAIGGQSNESDRY-IAPTV 239
Query: 374 VESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSY------GLTGAVFSQDK 427
+ EP+M+EEIFGP+L + +Q VD + L FS
Sbjct: 240 LVDVQETEPVMQEEIFGPILPIV---------NVQSVDEAIKFINRQEKPLALYAFSNSS 290
Query: 428 DVVQEATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGG------PHY---I 478
VV + + R ++G+F N+ T + PFGG SG G H+ +
Sbjct: 291 QVVNQMLE--RTSSGSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCL 348
Query: 479 LRWTSPQVIKETH-KPLGDWS 498
L + + +KE H P DW+
Sbjct: 349 LAPSGLEKLKEIHYPPYTDWN 369
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,063,672
Number of Sequences: 37866
Number of extensions: 918460
Number of successful extensions: 1831
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1723
Number of HSP's gapped (non-prelim): 41
length of query: 503
length of database: 18,247,518
effective HSP length: 107
effective length of query: 396
effective length of database: 14,195,856
effective search space: 5621558976
effective search space used: 5621558976
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.