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Search of human proteins with 236461846
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
(308 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 632 0.0
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 606 e-174
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 564 e-161
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 530 e-151
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 489 e-138
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 488 e-138
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 488 e-138
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 486 e-137
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 485 e-137
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 485 e-137
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 226 2e-59
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 221 6e-58
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 220 1e-57
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 217 1e-56
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens] 112 4e-25
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] 112 4e-25
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] 108 6e-24
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens] 108 8e-24
gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens] 99 4e-21
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens] 97 2e-20
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens] 96 5e-20
gi|66730481 neuregulin 3 [Homo sapiens] 87 2e-17
gi|20070380 neuregulin 4 [Homo sapiens] 49 7e-06
gi|4502461 betacellulin [Homo sapiens] 47 2e-05
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 45 6e-05
gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens] 44 2e-04
gi|61806622 epithelial mitogen [Homo sapiens] 43 3e-04
gi|24041035 notch 2 preproprotein [Homo sapiens] 42 5e-04
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 42 7e-04
gi|148833508 notch1 preproprotein [Homo sapiens] 41 0.002
>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
Length = 308
Score = 632 bits (1630), Expect = 0.0
Identities = 308/308 (100%), Positives = 308/308 (100%)
Query: 1 MQIPKHISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQP 60
MQIPKHISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQP
Sbjct: 1 MQIPKHISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQP 60
Query: 61 GFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL 120
GFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL
Sbjct: 61 GFTGARCTENVPMKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL 120
Query: 121 HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFST 180
HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFST
Sbjct: 121 HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFST 180
Query: 181 SHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNG 240
SHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNG
Sbjct: 181 SHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNG 240
Query: 241 TGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSS 300
TGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSS
Sbjct: 241 TGGPRECNSFLRHARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSS 300
Query: 301 IPHLGFIL 308
IPHLGFIL
Sbjct: 301 IPHLGFIL 308
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 606 bits (1562), Expect = e-174
Identities = 294/296 (99%), Positives = 296/296 (100%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 226
Query: 73 MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 132
MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER
Sbjct: 227 MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 286
Query: 133 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192
NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT
Sbjct: 287 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 346
Query: 193 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 252
VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR
Sbjct: 347 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 406
Query: 253 HARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL 308
HARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
Sbjct: 407 HARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL 462
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 564 bits (1454), Expect = e-161
Identities = 279/296 (94%), Positives = 283/296 (95%), Gaps = 3/296 (1%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV- 225
Query: 73 MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 132
+ + KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER
Sbjct: 226 --MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 283
Query: 133 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192
NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT
Sbjct: 284 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 343
Query: 193 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 252
VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR
Sbjct: 344 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 403
Query: 253 HARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL 308
HARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL
Sbjct: 404 HARETPDSYRDSPHSERHNLIAELRRNKAHRSKCMQIQLSATHLRSSSIPHLGFIL 459
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 530 bits (1365), Expect = e-151
Identities = 255/258 (98%), Positives = 258/258 (100%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 226
Query: 73 MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 132
MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER
Sbjct: 227 MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 286
Query: 133 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192
NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT
Sbjct: 287 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 346
Query: 193 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 252
VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR
Sbjct: 347 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 406
Query: 253 HARETPDSYRDSPHSERH 270
HARETPDSYRDSPHSER+
Sbjct: 407 HARETPDSYRDSPHSERY 424
>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
Length = 590
Score = 489 bits (1258), Expect = e-138
Identities = 242/270 (89%), Positives = 247/270 (91%), Gaps = 5/270 (1%)
Query: 6 HISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGA 65
+I+I + ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG
Sbjct: 105 NITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGD 164
Query: 66 RCTENVPMKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL 120
RC V +AEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL
Sbjct: 165 RCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKL 224
Query: 121 HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFST 180
HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFST
Sbjct: 225 HDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFST 284
Query: 181 SHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNG 240
SHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNG
Sbjct: 285 SHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNG 344
Query: 241 TGGPRECNSFLRHARETPDSYRDSPHSERH 270
TGGPRECNSFLRHARETPDSYRDSPHSER+
Sbjct: 345 TGGPRECNSFLRHARETPDSYRDSPHSERY 374
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 488 bits (1257), Expect = e-138
Identities = 240/258 (93%), Positives = 245/258 (94%), Gaps = 3/258 (1%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV- 225
Query: 73 MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 132
+ + KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER
Sbjct: 226 --MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 283
Query: 133 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192
NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT
Sbjct: 284 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 343
Query: 193 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 252
VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR
Sbjct: 344 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 403
Query: 253 HARETPDSYRDSPHSERH 270
HARETPDSYRDSPHSER+
Sbjct: 404 HARETPDSYRDSPHSERY 421
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 488 bits (1255), Expect = e-138
Identities = 240/257 (93%), Positives = 244/257 (94%), Gaps = 3/257 (1%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV- 225
Query: 73 MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 132
+ + KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER
Sbjct: 226 --MASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 283
Query: 133 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192
NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT
Sbjct: 284 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 343
Query: 193 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 252
VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR
Sbjct: 344 VTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLR 403
Query: 253 HARETPDSYRDSPHSER 269
HARETPDSYRDSPHSER
Sbjct: 404 HARETPDSYRDSPHSER 420
>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
Length = 607
Score = 486 bits (1251), Expect = e-137
Identities = 240/263 (91%), Positives = 243/263 (92%), Gaps = 5/263 (1%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
+ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 129 SATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 188
Query: 73 MKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 127
+AEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS
Sbjct: 189 ASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 248
Query: 128 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 187
LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA
Sbjct: 249 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 308
Query: 188 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 247
HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC
Sbjct: 309 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 368
Query: 248 NSFLRHARETPDSYRDSPHSERH 270
NSFLRHARETPDSYRDSPHSER+
Sbjct: 369 NSFLRHARETPDSYRDSPHSERY 391
>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
Length = 624
Score = 485 bits (1248), Expect = e-137
Identities = 239/263 (90%), Positives = 243/263 (92%), Gaps = 5/263 (1%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 146 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 205
Query: 73 MKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 127
+AEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS
Sbjct: 206 ASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 265
Query: 128 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 187
LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA
Sbjct: 266 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 325
Query: 188 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 247
HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC
Sbjct: 326 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 385
Query: 248 NSFLRHARETPDSYRDSPHSERH 270
NSFLRHARETPDSYRDSPHSER+
Sbjct: 386 NSFLRHARETPDSYRDSPHSERY 408
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 485 bits (1248), Expect = e-137
Identities = 239/263 (90%), Positives = 243/263 (92%), Gaps = 5/263 (1%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 226
Query: 73 MKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 127
+AEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS
Sbjct: 227 ASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 286
Query: 128 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 187
LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA
Sbjct: 287 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 346
Query: 188 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 247
HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC
Sbjct: 347 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 406
Query: 248 NSFLRHARETPDSYRDSPHSERH 270
NSFLRHARETPDSYRDSPHSER+
Sbjct: 407 NSFLRHARETPDSYRDSPHSERY 429
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 226 bits (576), Expect = 2e-59
Identities = 123/270 (45%), Positives = 175/270 (64%), Gaps = 19/270 (7%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
+ ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKC GF G RC E +P
Sbjct: 330 SVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGFFGQRCLEKLP 386
Query: 73 MKV---QNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLR 129
+++ ++KAEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++
Sbjct: 387 LRLYMPDPKQKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMC 446
Query: 130 SERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHH 189
N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH
Sbjct: 447 PAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHH 504
Query: 190 STTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNG 240
+T T T SH+WS +ES+ S+S S I++SSV S+ +SP R
Sbjct: 505 CSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYN 564
Query: 241 TGGPRECNSFLRHARETPDSYRDSPHSERH 270
R + H ++ DS RDSPHSER+
Sbjct: 565 LEERRRATAPPYH--DSVDSLRDSPHSERY 592
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 221 bits (563), Expect = 6e-58
Identities = 122/267 (45%), Positives = 171/267 (64%), Gaps = 19/267 (7%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
+ ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKC G+TG RC +
Sbjct: 330 SVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQ--- 383
Query: 73 MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSER 132
+ N KAEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++
Sbjct: 384 FAMVNFSKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAH 443
Query: 133 NNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTT 192
N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T
Sbjct: 444 QN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCST 501
Query: 193 VTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGG 243
T T SH+WS +ES+ S+S S I++SSV S+ +SP R
Sbjct: 502 ATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEE 561
Query: 244 PRECNSFLRHARETPDSYRDSPHSERH 270
R + H ++ DS RDSPHSER+
Sbjct: 562 RRRATAPPYH--DSVDSLRDSPHSERY 586
>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
Length = 858
Score = 220 bits (561), Expect = 1e-57
Identities = 122/278 (43%), Positives = 174/278 (62%), Gaps = 27/278 (9%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
+ ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKC GF G RC E +P
Sbjct: 330 SVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPNGFFGQRCLEKLP 386
Query: 73 MKVQNQE-----------KAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLH 121
+++ + +AEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H
Sbjct: 387 LRLYMPDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMH 446
Query: 122 DRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTS 181
+ LRQ++ N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+FS S
Sbjct: 447 NHLRQNMCPAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGS 504
Query: 182 HYTSTAHHSTTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TG 232
H S +HH +T T T SH+WS +ES+ S+S S I++SSV S+ +SP
Sbjct: 505 HSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEAR 564
Query: 233 GPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERH 270
R R + H ++ DS RDSPHSER+
Sbjct: 565 ARRAAAYNLEERRRATAPPYH--DSVDSLRDSPHSERY 600
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 217 bits (552), Expect = 1e-56
Identities = 120/272 (44%), Positives = 171/272 (62%), Gaps = 21/272 (7%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
+ ++T ++ + H KC E K++CVNGG C+ ++ ++ S CKC G+TG RC +
Sbjct: 330 SVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAM 386
Query: 73 MKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 127
+ ++AEELYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ+
Sbjct: 387 VNFSKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQN 446
Query: 128 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 187
+ N ++ANGP HP PE +Q+ + Y+SKNV +++H++ RE ET+FS SH S +
Sbjct: 447 MCPAHQN-RSLANGPSHPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPS 504
Query: 188 HHSTTVTQT-----PSHSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRL 238
HH +T T T SH+WS +ES+ S+S S I++SSV S+ +SP R
Sbjct: 505 HHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAA 564
Query: 239 NGTGGPRECNSFLRHARETPDSYRDSPHSERH 270
R + H ++ DS RDSPHSER+
Sbjct: 565 YNLEERRRATAPPYH--DSVDSLRDSPHSERY 594
>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
Length = 207
Score = 112 bits (280), Expect = 4e-25
Identities = 53/66 (80%), Positives = 56/66 (84%)
Query: 6 HISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGA 65
+I+I + ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG
Sbjct: 126 NITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGD 185
Query: 66 RCTENV 71
RC V
Sbjct: 186 RCQNYV 191
>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
Length = 422
Score = 112 bits (280), Expect = 4e-25
Identities = 53/66 (80%), Positives = 56/66 (84%)
Query: 6 HISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGA 65
+I+I + ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG
Sbjct: 341 NITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGD 400
Query: 66 RCTENV 71
RC V
Sbjct: 401 RCQNYV 406
>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
Length = 241
Score = 108 bits (270), Expect = 6e-24
Identities = 50/59 (84%), Positives = 52/59 (88%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 225
>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
Length = 296
Score = 108 bits (269), Expect = 8e-24
Identities = 50/58 (86%), Positives = 51/58 (87%)
Query: 14 ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 280
>gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]
Length = 177
Score = 99.4 bits (246), Expect = 4e-21
Identities = 46/52 (88%), Positives = 49/52 (94%)
Query: 6 HISIEDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 57
+I+I + ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 126 NITIVESNATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 177
>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
Length = 194
Score = 96.7 bits (239), Expect = 2e-20
Identities = 44/45 (97%), Positives = 45/45 (100%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 57
+ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 150 SATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 194
>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
Length = 211
Score = 95.5 bits (236), Expect = 5e-20
Identities = 43/45 (95%), Positives = 45/45 (100%)
Query: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 57
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
>gi|66730481 neuregulin 3 [Homo sapiens]
Length = 696
Score = 87.0 bits (214), Expect = 2e-17
Identities = 63/244 (25%), Positives = 116/244 (47%), Gaps = 26/244 (10%)
Query: 15 TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP-- 72
T+ ST + H C +K+ +C+N GECF+++ L+ ++ C+C+ G+ G RC + +P
Sbjct: 277 TTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKH-CRCKEGYQGVRCDQFLPKT 335
Query: 73 ----------MKVQNQEKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHD 122
+ ++ E +EE+YQ++VL+I+ I +++VG+ C Y K+KKQ K++ +
Sbjct: 336 DSILSDPTDHLGIEFME-SEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQE 394
Query: 123 RLRQSLRSERNNMMNIANGPHHPNPPPENVQLVN-QYVSKNVISSEHIVEREAETSFSTS 181
+L+ + ++ + N +VQL N V ++ +++ +E+ E+SF
Sbjct: 395 QLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTA---LEKMMESSF--- 448
Query: 182 HYTSTAHHSTTVTQTPSH-SWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNG 240
S +P S S H S+ S + + PR RL G
Sbjct: 449 ----VGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGG 504
Query: 241 TGGP 244
GP
Sbjct: 505 IVGP 508
>gi|20070380 neuregulin 4 [Homo sapiens]
Length = 115
Score = 48.5 bits (114), Expect = 7e-06
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 3/48 (6%)
Query: 22 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTE 69
T H C K+FC+NGG C+++ + +P C+C +TGARC E
Sbjct: 3 TDHEEPCGPSHKSFCLNGGLCYVIPTIPSP---FCRCVENYTGARCEE 47
>gi|4502461 betacellulin [Homo sapiens]
Length = 178
Score = 47.0 bits (110), Expect = 2e-05
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 22/118 (18%)
Query: 10 EDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTE 69
E+ AT+T + H +C ++ K +C+ G C V PS C C G+ GARC E
Sbjct: 51 ENCAATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS---CVCDEGYIGARC-E 105
Query: 70 NVPMKVQNQEKAEELYQKRVLTITGIC-IALLVVGIMCVVAYC-------KTKKQRKK 119
V + ++ + I IC IA++VV I+ V+ C K +K++KK
Sbjct: 106 RVDLFYLRGDRGQ---------ILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKK 154
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 45.4 bits (106), Expect = 6e-05
Identities = 35/122 (28%), Positives = 55/122 (45%), Gaps = 23/122 (18%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGI 95
CVNGG C +DL N ++ C C F G RC ++ A++L TI +
Sbjct: 1306 CVNGGLC---QDLLN--KFQCLCDVAFAGERCEVDL---------ADDLISDIFTTIGSV 1351
Query: 96 CIALLVVGIMCVVAYCKTKKQR--KKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQ 153
+ALL++ ++ +VA T +R + + RQ R M N+ PPP +
Sbjct: 1352 TVALLLILLLAIVASVVTSNKRATQGTYSPSRQEKEGSRVEMWNLM-------PPPAMER 1404
Query: 154 LV 155
L+
Sbjct: 1405 LI 1406
Score = 34.3 bits (77), Expect = 0.14
Identities = 13/20 (65%), Positives = 15/20 (75%)
Query: 52 SRYLCKCQPGFTGARCTENV 71
S Y+C CQPGFTG C E+V
Sbjct: 379 SGYVCICQPGFTGIHCEEDV 398
Score = 28.9 bits (63), Expect = 6.0
Identities = 16/46 (34%), Positives = 22/46 (47%), Gaps = 6/46 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTEN-VPMKVQNQEK 80
C NG C +S+ + Y C C FTG C ++ +P V EK
Sbjct: 1223 CANGATC-----ISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEK 1263
Score = 28.5 bits (62), Expect = 7.9
Identities = 13/35 (37%), Positives = 14/35 (40%), Gaps = 5/35 (14%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTEN 70
C+NG C Y C C PGF G C N
Sbjct: 233 CLNGATC-----QDALGAYFCDCAPGFLGDHCELN 262
Score = 28.5 bits (62), Expect = 7.9
Identities = 9/14 (64%), Positives = 11/14 (78%)
Query: 54 YLCKCQPGFTGARC 67
Y C C PG+TGA+C
Sbjct: 323 YTCHCWPGYTGAQC 336
Score = 28.5 bits (62), Expect = 7.9
Identities = 15/45 (33%), Positives = 21/45 (46%), Gaps = 15/45 (33%)
Query: 37 VNGGECFMVKDLSNP----------SRYLCKCQPGFTGARCTENV 71
+N ECF SNP + Y C C+PG+TG C ++
Sbjct: 1176 LNIDECF-----SNPCIHGNCSDRVAAYHCTCEPGYTGVNCEVDI 1215
>gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]
Length = 208
Score = 43.5 bits (101), Expect = 2e-04
Identities = 26/81 (32%), Positives = 45/81 (55%), Gaps = 9/81 (11%)
Query: 28 CAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEE---L 84
C K K FC++G EC VK+L PS C C PG+ G RC + + V+N+ + +
Sbjct: 108 CLRKYKDFCIHG-ECKYVKELRAPS---CICHPGYHGERC-HGLSLPVENRLYTYDHTTI 162
Query: 85 YQKRVLTITGICIALLVVGIM 105
+ ++ +C+ L++VG++
Sbjct: 163 LAVVAVVLSSVCL-LVIVGLL 182
>gi|61806622 epithelial mitogen [Homo sapiens]
Length = 133
Score = 43.1 bits (100), Expect = 3e-04
Identities = 31/97 (31%), Positives = 52/97 (53%), Gaps = 14/97 (14%)
Query: 23 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAE 82
SHL C E ++C+NG C +L + +C+C G+TG RC E++ + A
Sbjct: 48 SHL--CLEDHNSYCINGA-CAFHHELE---KAICRCFTGYTGERC-EHLTL----TSYAV 96
Query: 83 ELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKK 119
+ Y+K + GI + LL+ G + V+ YC +K+ +K
Sbjct: 97 DSYEKYI--AIGIGVGLLLSGFL-VIFYCYIRKRYEK 130
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 42.4 bits (98), Expect = 5e-04
Identities = 15/32 (46%), Positives = 23/32 (71%), Gaps = 2/32 (6%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARC 67
C+NGG C + ++ P ++C+C PGF+GARC
Sbjct: 1313 CLNGGTCAVASNM--PDGFICRCPPGFSGARC 1342
Score = 39.7 bits (91), Expect = 0.003
Identities = 18/52 (34%), Positives = 27/52 (51%), Gaps = 5/52 (9%)
Query: 20 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
TG + + T C+NG +C + +P+ Y C+C GFTG C EN+
Sbjct: 525 TGPVCQIDIDDCSSTPCLNGAKC-----IDHPNGYECQCATGFTGVLCEENI 571
Score = 37.7 bits (86), Expect = 0.013
Identities = 19/62 (30%), Positives = 29/62 (46%), Gaps = 5/62 (8%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRVLTITGI 95
C+NGG+C + Y C+C PGF G RC ++ + N +E LT +
Sbjct: 1235 CLNGGQC-----MDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTNDYL 1289
Query: 96 CI 97
C+
Sbjct: 1290 CV 1291
Score = 36.6 bits (83), Expect = 0.029
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 4/36 (11%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
CVNGG C D + + C C PGF G+ C N+
Sbjct: 230 CVNGGTCRQTGDFT----FECNCLPGFEGSTCERNI 261
Score = 35.8 bits (81), Expect = 0.049
Identities = 17/36 (47%), Positives = 18/36 (50%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG C D N Y CKCQ GF G C N+
Sbjct: 958 CKNGGTC---SDYVNS--YTCKCQAGFDGVHCENNI 988
Score = 35.0 bits (79), Expect = 0.084
Identities = 15/32 (46%), Positives = 18/32 (56%), Gaps = 4/32 (12%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARC 67
C+NGG C M+ + Y C CQ GFTG C
Sbjct: 115 CLNGGTCHML----SRDTYECTCQVGFTGKEC 142
Score = 33.9 bits (76), Expect = 0.19
Identities = 14/32 (43%), Positives = 18/32 (56%), Gaps = 5/32 (15%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARC 67
CVN G+C + +R+ C C PGFTG C
Sbjct: 503 CVNNGQC-----VDKVNRFQCLCPPGFTGPVC 529
Score = 33.5 bits (75), Expect = 0.24
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG C + + Y C+C P +TG CTE+V
Sbjct: 269 CQNGGVC-----VDGVNTYNCRCPPQWTGQFCTEDV 299
Score = 33.5 bits (75), Expect = 0.24
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C+N G C + Y+C+C PGF+G C E++
Sbjct: 882 CMNHGLCH-----NTQGSYMCECPPGFSGMDCEEDI 912
Score = 32.7 bits (73), Expect = 0.42
Identities = 16/36 (44%), Positives = 18/36 (50%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG C DL N + C C PG G C EN+
Sbjct: 1196 CQNGGTCI---DLVN--HFKCSCPPGTRGLLCEENI 1226
Score = 32.3 bits (72), Expect = 0.54
Identities = 14/36 (38%), Positives = 19/36 (52%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NG C V + ++ CKC GFTG +C +V
Sbjct: 153 CANGSTCTTVAN-----QFSCKCLTGFTGQKCETDV 183
Score = 32.3 bits (72), Expect = 0.54
Identities = 16/35 (45%), Positives = 18/35 (51%), Gaps = 5/35 (14%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTEN 70
C+N G C DL N Y C CQPG +G C N
Sbjct: 616 CLNDGRCI---DLVNG--YQCNCQPGTSGVNCEIN 645
Score = 32.3 bits (72), Expect = 0.54
Identities = 13/32 (40%), Positives = 17/32 (53%), Gaps = 5/32 (15%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARC 67
C NGG C + + + C C PGFTG +C
Sbjct: 920 CQNGGSC-----MDGVNTFSCLCLPGFTGDKC 946
Score = 32.3 bits (72), Expect = 0.54
Identities = 13/32 (40%), Positives = 18/32 (56%), Gaps = 3/32 (9%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARC 67
C +GG C + P Y C+C P F+G+RC
Sbjct: 1383 CQHGGSCHPQRQ---PPYYSCQCAPPFSGSRC 1411
Score = 32.0 bits (71), Expect = 0.71
Identities = 14/32 (43%), Positives = 17/32 (53%), Gaps = 5/32 (15%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARC 67
C +GG C L+ P Y C+C GFTG C
Sbjct: 192 CQHGGTC-----LNLPGSYQCQCPQGFTGQYC 218
Score = 32.0 bits (71), Expect = 0.71
Identities = 11/20 (55%), Positives = 14/20 (70%)
Query: 52 SRYLCKCQPGFTGARCTENV 71
+RY C C PGFTG RC ++
Sbjct: 664 NRYSCVCSPGFTGQRCNIDI 683
Score = 31.6 bits (70), Expect = 0.93
Identities = 14/36 (38%), Positives = 18/36 (50%), Gaps = 3/36 (8%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C N C K+ N Y C C PG+ G RCT ++
Sbjct: 842 CENAAVC---KESPNFESYTCLCAPGWQGQRCTIDI 874
Score = 31.2 bits (69), Expect = 1.2
Identities = 15/36 (41%), Positives = 17/36 (47%), Gaps = 3/36 (8%)
Query: 32 EKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARC 67
EK C NGG C L + C+C GFTG C
Sbjct: 69 EKNRCQNGGTCVAQAMLGKAT---CRCASGFTGEDC 101
Score = 30.0 bits (66), Expect = 2.7
Identities = 12/25 (48%), Positives = 17/25 (68%), Gaps = 2/25 (8%)
Query: 49 SNP--SRYLCKCQPGFTGARCTENV 71
+NP +Y+C C G+ GA CTE+V
Sbjct: 392 TNPLNGQYICTCPQGYKGADCTEDV 416
Score = 29.3 bits (64), Expect = 4.6
Identities = 15/36 (41%), Positives = 18/36 (50%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG C +L N Y C C+ GF G C N+
Sbjct: 766 CQNGGTC---DNLVNG--YRCTCKKGFKGYNCQVNI 796
Score = 29.3 bits (64), Expect = 4.6
Identities = 14/49 (28%), Positives = 23/49 (46%), Gaps = 8/49 (16%)
Query: 23 SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
+++ +C E C NGG C + + + C C GFTG+ C +
Sbjct: 986 NNINECTESS---CFNGGTC-----VDGINSFSCLCPVGFTGSFCLHEI 1026
Score = 28.5 bits (62), Expect = 7.9
Identities = 13/36 (36%), Positives = 18/36 (50%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG C + Y C C G++G C+EN+
Sbjct: 309 CQNGGTC-----ANRNGGYGCVCVNGWSGDDCSENI 339
Score = 28.5 bits (62), Expect = 7.9
Identities = 12/50 (24%), Positives = 23/50 (46%), Gaps = 5/50 (10%)
Query: 22 TSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
T + +CA C + G+C ++ + C+C G+ G RC ++
Sbjct: 413 TEDVDECAMANSNPCEHAGKC-----VNTDGAFHCECLKGYAGPRCEMDI 457
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 42.0 bits (97), Expect = 7e-04
Identities = 34/114 (29%), Positives = 50/114 (43%), Gaps = 10/114 (8%)
Query: 30 EKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQKRV 89
E E+ C NGG C V +LC C PG+ G C P+ V N + K
Sbjct: 4101 ECEREECENGGSCVNVF-----GSFLCNCTPGYVGQYCGLR-PVVVPNIQAGHSYVGKEE 4154
Query: 90 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNN--MMNIANG 141
L GI + L V+ I+ V+ KK +K + R +L + ++N +NG
Sbjct: 4155 L--IGIAVVLFVIFILVVLFIVFRKKVFRKNYSRNNITLVQDPATAALLNKSNG 4206
Score = 31.2 bits (69), Expect = 1.2
Identities = 12/36 (33%), Positives = 19/36 (52%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG C + + ++C C+ G TG C E++
Sbjct: 4069 CRNGGSCDPIGNT-----FICNCKAGLTGVTCEEDI 4099
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 40.8 bits (94), Expect = 0.002
Identities = 21/52 (40%), Positives = 30/52 (57%), Gaps = 5/52 (9%)
Query: 20 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
+GT+ + E E CVNGG C KD++ S Y+C C+ GF+G C N+
Sbjct: 746 SGTNCDINNNECESNPCVNGGTC---KDMT--SGYVCTCREGFSGPNCQTNI 792
Score = 37.7 bits (86), Expect = 0.013
Identities = 21/58 (36%), Positives = 26/58 (44%), Gaps = 7/58 (12%)
Query: 14 ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
AT T V C+ C NGG C D+++ C C PGFTG C EN+
Sbjct: 208 ATHTGPNCERPYVPCSPSP---CQNGGTCRPTGDVTHE----CACLPGFTGQNCEENI 258
Score = 34.7 bits (78), Expect = 0.11
Identities = 15/37 (40%), Positives = 20/37 (54%), Gaps = 4/37 (10%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
C NGG C DL + Y C+C PG++G C + P
Sbjct: 111 CRNGGTC----DLLTLTEYKCRCPPGWSGKSCQQADP 143
Score = 34.3 bits (77), Expect = 0.14
Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG C + + Y C+C P +TG CTE+V
Sbjct: 266 CKNGGAC-----VDGVNTYNCRCPPEWTGQYCTEDV 296
Score = 34.3 bits (77), Expect = 0.14
Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 7/52 (13%)
Query: 22 TSHLVKCAEKE--KTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
T HL + E T C NG +C L P+ Y C C G+TG C ++
Sbjct: 521 TGHLCQYDVDECASTPCKNGAKC-----LDGPNTYTCVCTEGYTGTHCEVDI 567
Score = 33.9 bits (76), Expect = 0.19
Identities = 14/36 (38%), Positives = 19/36 (52%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG+C L + Y+C C P F G C ++V
Sbjct: 149 CANGGQC-----LPFEASYICHCPPSFHGPTCRQDV 179
Score = 33.9 bits (76), Expect = 0.19
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 4/33 (12%)
Query: 36 CVNGGECFMVKDLSNPSR-YLCKCQPGFTGARC 67
C NGG C + SN +R ++CKC GF GA C
Sbjct: 1316 CKNGGTCAVA---SNTARGFICKCPAGFEGATC 1345
Score = 33.5 bits (75), Expect = 0.24
Identities = 14/36 (38%), Positives = 19/36 (52%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG C + + + C C PGFTG+ C +V
Sbjct: 992 CFNGGTC-----VDGINSFTCLCPPGFTGSYCQHDV 1022
Score = 32.0 bits (71), Expect = 0.71
Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 8/63 (12%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARC-TENVPMKVQNQEKAEELYQKRVLTITG 94
C NGG+C+ ++Y C+C G+TG C +V +V Q + ++ R+ G
Sbjct: 1068 CKNGGKCWQTH-----TQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDV--ARLCQHGG 1120
Query: 95 ICI 97
+C+
Sbjct: 1121 LCV 1123
Score = 31.6 bits (70), Expect = 0.93
Identities = 14/36 (38%), Positives = 16/36 (44%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C N G C + Y C C PGF G RC +V
Sbjct: 1238 CFNNGTC-----VDQVGGYSCTCPPGFVGERCEGDV 1268
Score = 30.8 bits (68), Expect = 1.6
Identities = 14/36 (38%), Positives = 18/36 (50%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG C + Y C C G+TG C+EN+
Sbjct: 306 CQNGGTCH-----NTHGGYNCVCVNGWTGEDCSENI 336
Score = 30.8 bits (68), Expect = 1.6
Identities = 14/37 (37%), Positives = 15/37 (40%), Gaps = 5/37 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
C NG C D Y C C GF+G C N P
Sbjct: 954 CRNGANCTDCVD-----SYTCTCPAGFSGIHCENNTP 985
Score = 29.6 bits (65), Expect = 3.5
Identities = 14/34 (41%), Positives = 17/34 (50%), Gaps = 1/34 (2%)
Query: 34 TFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARC 67
T C N G C +V D + Y C C GF+G C
Sbjct: 66 TPCKNAGTCHVV-DRRGVADYACSCALGFSGPLC 98
Score = 29.6 bits (65), Expect = 3.5
Identities = 9/18 (50%), Positives = 13/18 (72%)
Query: 54 YLCKCQPGFTGARCTENV 71
Y C C+PG+TG+ C N+
Sbjct: 662 YECACEPGYTGSMCNINI 679
Score = 29.3 bits (64), Expect = 4.6
Identities = 13/36 (36%), Positives = 16/36 (44%), Gaps = 5/36 (13%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
C NGG C + C C PGF G C E++
Sbjct: 916 CHNGGSC-----TDGINTAFCDCLPGFRGTFCEEDI 946
Score = 28.9 bits (63), Expect = 6.0
Identities = 16/52 (30%), Positives = 24/52 (46%), Gaps = 3/52 (5%)
Query: 20 TGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENV 71
TG + V A + C NGGEC +D + + C C G+ G C ++
Sbjct: 822 TGATCEVVLAPCAPSPCRNGGECRQSEDYES---FSCVCPTGWQGQTCEVDI 870
Score = 28.5 bits (62), Expect = 7.9
Identities = 13/32 (40%), Positives = 15/32 (46%), Gaps = 5/32 (15%)
Query: 36 CVNGGECFMVKDLSNPSRYLCKCQPGFTGARC 67
C+NGG C +S P C C FTG C
Sbjct: 1357 CLNGGTC-----ISGPRSPTCLCLGPFTGPEC 1383
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.127 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,274,218
Number of Sequences: 37866
Number of extensions: 634221
Number of successful extensions: 3670
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 63
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 2914
Number of HSP's gapped (non-prelim): 838
length of query: 308
length of database: 18,247,518
effective HSP length: 102
effective length of query: 206
effective length of database: 14,385,186
effective search space: 2963348316
effective search space used: 2963348316
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.