Search of human proteins with 23510445

Search of human proteins with 23510445

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|23510445 tumor necrosis factor (ligand) superfamily, member
15 [Homo sapiens]
         (251 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|23510445 tumor necrosis factor (ligand) superfamily, member 1...   512   e-145
gi|25952111 tumor necrosis factor alpha [Homo sapiens]                 81   8e-16
gi|25952144 tumor necrosis factor ligand superfamily, member 14 ...    74   9e-14
gi|4557329 fas ligand [Homo sapiens]                                   74   1e-13
gi|25952147 tumor necrosis factor ligand superfamily, member 14 ...    72   6e-13
gi|6806893 lymphotoxin alpha precursor [Homo sapiens]                  63   3e-10
gi|229092381 lymphotoxin alpha precursor [Homo sapiens]                63   3e-10
gi|4507593 tumor necrosis factor (ligand) superfamily, member 10...    60   2e-09
gi|4505035 lymphotoxin-beta isoform a [Homo sapiens]                   48   9e-06
gi|4557433 CD40 ligand [Homo sapiens]                                  37   0.016
gi|224548983 tumor necrosis factor superfamily, member 13b isofo...    30   2.0  
gi|5730097 tumor necrosis factor superfamily, member 13b isoform...    29   3.4  
gi|54112101 ectodysplasin A isoform EDA-A2 [Homo sapiens]              29   3.4  

>gi|23510445 tumor necrosis factor (ligand) superfamily, member 15
           [Homo sapiens]
          Length = 251

 Score =  512 bits (1319), Expect = e-145
 Identities = 251/251 (100%), Positives = 251/251 (100%)

Query: 1   MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLR 60
           MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLR
Sbjct: 1   MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLR 60

Query: 61  AQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWE 120
           AQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWE
Sbjct: 61  AQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWE 120

Query: 121 HELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVV 180
           HELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVV
Sbjct: 121 HELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVV 180

Query: 181 ITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTK 240
           ITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTK
Sbjct: 181 ITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTK 240

Query: 241 EDKTFFGAFLL 251
           EDKTFFGAFLL
Sbjct: 241 EDKTFFGAFLL 251


>gi|25952111 tumor necrosis factor alpha [Homo sapiens]
          Length = 233

 Score = 81.3 bits (199), Expect = 8e-16
 Identities = 52/181 (28%), Positives = 80/181 (44%), Gaps = 25/181 (13%)

Query: 78  APSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNK 137
           +P  Q V +  R   DKP AH+    Q   Q        L W +    A   N +   + 
Sbjct: 71  SPLAQAVRSSSRTPSDKPVAHVVANPQAEGQ--------LQWLNRRANALLANGVELRDN 122

Query: 138 FLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMG 197
            L++P  G Y IYSQV F+G           G P+    +T  I+++  SY     LL  
Sbjct: 123 QLVVPSEGLYLIYSQVLFKGQ----------GCPSTHVLLTHTISRIAVSYQTKVNLLSA 172

Query: 198 TKSVCE-------VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFL 250
            KS C+           W++PIYLG +F L++GD+L   ++    +D+ +  + +FG   
Sbjct: 173 IKSPCQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIA 232

Query: 251 L 251
           L
Sbjct: 233 L 233


>gi|25952144 tumor necrosis factor ligand superfamily, member 14
           isoform 1 precursor [Homo sapiens]
          Length = 240

 Score = 74.3 bits (181), Expect = 9e-14
 Identities = 63/215 (29%), Positives = 102/215 (47%), Gaps = 27/215 (12%)

Query: 49  GLTTYLLVSQLRAQGEACVQFQALKGQEF-------APSHQQVYAPLRADGDKPRAHLTV 101
           GL   L+ + L  QG   +Q     G+         A S +Q+    R+    P AHLT 
Sbjct: 41  GLLLLLMGAGLAVQGWFLLQLHWRLGEMVTRLPDGPAGSWEQLIQERRSHEVNPAAHLTG 100

Query: 102 VRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSE 161
              + T         L WE +LGLAF +  ++Y +  L++ ++G Y+IYS+V   G+   
Sbjct: 101 ANSSLT----GSGGPLLWETQLGLAFLRG-LSYHDGALVVTKAGYYYIYSKVQLGGV--- 152

Query: 162 CSEIRQAGRP-NKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSN----WFQPIYLGA 216
                  G P     +IT  + K T  YPE  +LL+  +S C   ++    W+   +LG 
Sbjct: 153 -------GCPLGLASTITHGLYKRTPRYPEELELLVSQQSPCGRATSSSRVWWDSSFLGG 205

Query: 217 MFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL 251
           +  L+ G+K++V V D  LV      +++FGAF++
Sbjct: 206 VVHLEAGEKVVVRVLDERLVRLRDGTRSYFGAFMV 240


>gi|4557329 fas ligand [Homo sapiens]
          Length = 281

 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 49/136 (36%), Positives = 70/136 (51%), Gaps = 15/136 (11%)

Query: 117 LHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDS 176
           L WE   G+      + Y    L+I E+G YF+YS+V FRG +            N P S
Sbjct: 160 LEWEDTYGIVLLSG-VKYKKGGLVINETGLYFVYSKVYFRGQSCN----------NLPLS 208

Query: 177 ITVVITKVTDSYPEPTQLLMGTK-SVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISL 235
             V +      YP+   ++ G   S C  G  W +  YLGA+F+L   D L VNVS++SL
Sbjct: 209 HKVYMRN--SKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLTSADHLYVNVSELSL 266

Query: 236 VDYTKEDKTFFGAFLL 251
           V++ +E +TFFG + L
Sbjct: 267 VNF-EESQTFFGLYKL 281


>gi|25952147 tumor necrosis factor ligand superfamily, member 14
           isoform 2 [Homo sapiens]
          Length = 204

 Score = 71.6 bits (174), Expect = 6e-13
 Identities = 54/179 (30%), Positives = 90/179 (50%), Gaps = 20/179 (11%)

Query: 78  APSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNK 137
           A S +Q+    R+    P AHLT    + T         L WE +LGLAF +  ++Y + 
Sbjct: 41  AGSWEQLIQERRSHEVNPAAHLTGANSSLT----GSGGPLLWETQLGLAFLRG-LSYHDG 95

Query: 138 FLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRP-NKPDSITVVITKVTDSYPEPTQLLM 196
            L++ ++G Y+IYS+V   G+          G P     +IT  + K T  YPE  +LL+
Sbjct: 96  ALVVTKAGYYYIYSKVQLGGV----------GCPLGLASTITHGLYKRTPRYPEELELLV 145

Query: 197 GTKSVCEVGSN----WFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL 251
             +S C   ++    W+   +LG +  L+ G++++V V D  LV      +++FGAF++
Sbjct: 146 SQQSPCGRATSSSRVWWDSSFLGGVVHLEAGEEVVVRVLDERLVRLRDGTRSYFGAFMV 204


>gi|6806893 lymphotoxin alpha precursor [Homo sapiens]
          Length = 205

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 59/214 (27%), Positives = 84/214 (39%), Gaps = 19/214 (8%)

Query: 42  VLLPFLAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTV 101
           + LP + G T +LL+  L          Q L G    PS  Q           P+ HL  
Sbjct: 7   LFLPRVCGTTLHLLLLGLLLV--LLPGAQGLPGVGLTPSAAQTAR------QHPKMHLAH 58

Query: 102 VRQTPTQHF---KNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGM 158
               P  H     ++  +L W      AF ++  + +N  LL+P SG YF+YSQV F G 
Sbjct: 59  STLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSG- 117

Query: 159 TSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAM 217
                +       + P  +   +   +  YP    LL   K V   +   W   +Y GA 
Sbjct: 118 -----KAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAA 172

Query: 218 FSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL 251
           F L +GD+L  +   I  +        FFGAF L
Sbjct: 173 FQLTQGDQLSTHTDGIPHL-VLSPSTVFFGAFAL 205


>gi|229092381 lymphotoxin alpha precursor [Homo sapiens]
          Length = 205

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 59/214 (27%), Positives = 84/214 (39%), Gaps = 19/214 (8%)

Query: 42  VLLPFLAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTV 101
           + LP + G T +LL+  L          Q L G    PS  Q           P+ HL  
Sbjct: 7   LFLPRVCGTTLHLLLLGLLLV--LLPGAQGLPGVGLTPSAAQTAR------QHPKMHLAH 58

Query: 102 VRQTPTQHF---KNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGM 158
               P  H     ++  +L W      AF ++  + +N  LL+P SG YF+YSQV F G 
Sbjct: 59  STLKPAAHLIGDPSKQNSLLWRANTDRAFLQDGFSLSNNSLLVPTSGIYFVYSQVVFSG- 117

Query: 159 TSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCE-VGSNWFQPIYLGAM 217
                +       + P  +   +   +  YP    LL   K V   +   W   +Y GA 
Sbjct: 118 -----KAYSPKATSSPLYLAHEVQLFSSQYPFHVPLLSSQKMVYPGLQEPWLHSMYHGAA 172

Query: 218 FSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL 251
           F L +GD+L  +   I  +        FFGAF L
Sbjct: 173 FQLTQGDQLSTHTDGIPHL-VLSPSTVFFGAFAL 205


>gi|4507593 tumor necrosis factor (ligand) superfamily, member 10
           [Homo sapiens]
          Length = 281

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 47/136 (34%), Positives = 72/136 (52%), Gaps = 12/136 (8%)

Query: 119 WEHEL-GLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSI 177
           WE    G +F  N ++  N  L+I E G Y+IYSQ  FR       EI++  + +K   +
Sbjct: 154 WESSRSGHSFLSN-LHLRNGELVIHEKGFYYIYSQTYFRFQ----EEIKENTKNDK--QM 206

Query: 178 TVVITKVTDSYPEPTQLLMGTKSVC--EVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISL 235
              I K T SYP+P  L+   ++ C  +        IY G +F L+E D++ V+V++  L
Sbjct: 207 VQYIYKYT-SYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHL 265

Query: 236 VDYTKEDKTFFGAFLL 251
           +D   E  +FFGAFL+
Sbjct: 266 IDMDHE-ASFFGAFLV 280


>gi|4505035 lymphotoxin-beta isoform a [Homo sapiens]
          Length = 244

 Score = 47.8 bits (112), Expect = 9e-06
 Identities = 39/149 (26%), Positives = 70/149 (46%), Gaps = 21/149 (14%)

Query: 117 LHWEHELGLAFTKNRMNYTN-KFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPD 175
           L WE     AF  +   +++ + L +P+ G Y++Y  V +RG           G   +  
Sbjct: 102 LGWETTKEQAFLTSGTQFSDAEGLALPQDGLYYLYCLVGYRGRAPP------GGGDPQGR 155

Query: 176 SITV--VITKVTDSYPE--PTQLLMGTKSVCEV---------GSNWFQPIYLGAMFSLQE 222
           S+T+   + +   +Y    P  LL G ++V  V         G  W+  +  G +  L+ 
Sbjct: 156 SVTLRSSLYRAGGAYGPGTPELLLEGAETVTPVLDPARRQGYGPLWYTSVGFGGLVQLRR 215

Query: 223 GDKLMVNVSDISLVDYTKEDKTFFGAFLL 251
           G+++ VN+S   +VD+ +  KTFFGA ++
Sbjct: 216 GERVYVNISHPDMVDFAR-GKTFFGAVMV 243


>gi|4557433 CD40 ligand [Homo sapiens]
          Length = 261

 Score = 37.0 bits (84), Expect = 0.016
 Identities = 36/123 (29%), Positives = 53/123 (43%), Gaps = 12/123 (9%)

Query: 117 LHWEHELGLAFTKNRMNYTN-KFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPD 175
           L W  +     + N +   N K L +   G Y+IY+QVTF      CS  R+A   ++  
Sbjct: 138 LQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTF------CSN-REAS--SQAP 188

Query: 176 SITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISL 235
            I  +  K    +         T S  +      Q I+LG +F LQ G  + VNV+D S 
Sbjct: 189 FIASLCLKSPGRFERILLRAANTHSSAKPCGQ--QSIHLGGVFELQPGASVFVNVTDPSQ 246

Query: 236 VDY 238
           V +
Sbjct: 247 VSH 249


>gi|224548983 tumor necrosis factor superfamily, member 13b isoform
           2 [Homo sapiens]
          Length = 266

 Score = 30.0 bits (66), Expect = 2.0
 Identities = 53/228 (23%), Positives = 89/228 (39%), Gaps = 32/228 (14%)

Query: 37  LTCCLVLLPF--LAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDK 94
           L+CCL ++ F  +A L   L   +   QG    +  A  G   AP      AP    G K
Sbjct: 57  LSCCLTVVSFYQVAALQGDLASLRAELQGHHAEKLPAGAG---APKAGLEEAPAVTAGLK 113

Query: 95  PRAHLTVVRQTPTQHFKNQFPALHWEHELG--------LAFTK-NRMNYTNKFLLIPESG 145
                       +Q+ +N+  A+    E G        L+F + + +      +L+ E+G
Sbjct: 114 IFEPPAPGEGNSSQNSRNK-RAVQGPEETGSYTFVPWLLSFKRGSALEEKENKILVKETG 172

Query: 146 DYFIYSQVTFRGMTSECSEIRQAGRPNK-PDSITVV-ITKVTDSYPEPTQLLMGTKSVCE 203
            +FIY QV +   T     + Q  + +   D +++V + +   + PE         + C 
Sbjct: 173 YFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL-----PNNSC- 226

Query: 204 VGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL 251
                    Y   +  L+EGD+L + +   +       D TFFGA  L
Sbjct: 227 ---------YSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKL 265


>gi|5730097 tumor necrosis factor superfamily, member 13b isoform 1
           [Homo sapiens]
          Length = 285

 Score = 29.3 bits (64), Expect = 3.4
 Identities = 28/115 (24%), Positives = 49/115 (42%), Gaps = 17/115 (14%)

Query: 139 LLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNK-PDSITVV-ITKVTDSYPEPTQLLM 196
           +L+ E+G +FIY QV +   T     + Q  + +   D +++V + +   + PE      
Sbjct: 185 ILVKETGYFFIYGQVLYTDKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETL---- 240

Query: 197 GTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL 251
              + C          Y   +  L+EGD+L + +   +       D TFFGA  L
Sbjct: 241 -PNNSC----------YSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKL 284


>gi|54112101 ectodysplasin A isoform EDA-A2 [Homo sapiens]
          Length = 389

 Score = 29.3 bits (64), Expect = 3.4
 Identities = 40/159 (25%), Positives = 59/159 (37%), Gaps = 33/159 (20%)

Query: 104 QTPTQHFKNQFPALHWEHEL--GLAFTKNRMNYTNK-FLLIPESGD--------YFIYSQ 152
           Q    H + Q  A+  +++L  G+    +R+    K F L P SG+        YFIYSQ
Sbjct: 247 QPAVVHLQGQGSAIQVKNDLSGGVLNDWSRITMNPKVFKLHPRSGELEVLVDGTYFIYSQ 306

Query: 153 VTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPI 212
           V +   T   S                    V D  P     L  T+S+ E G   +   
Sbjct: 307 VYYINFTDFAS-----------------YEVVVDEKP----FLQCTRSI-ETGKTNYNTC 344

Query: 213 YLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL 251
           Y   +  L+   K+ V +    +     +  TFFGA  L
Sbjct: 345 YTAGVCLLKARQKIAVKMVHADISINMSKHTTFFGAIRL 383


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.134    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,631,832
Number of Sequences: 37866
Number of extensions: 409459
Number of successful extensions: 815
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 791
Number of HSP's gapped (non-prelim): 13
length of query: 251
length of database: 18,247,518
effective HSP length: 100
effective length of query: 151
effective length of database: 14,460,918
effective search space: 2183598618
effective search space used: 2183598618
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.