Search of human proteins with 116008447

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116008447 CAP-GLY domain containing linker protein 2 isoform
1 [Homo sapiens]
         (1046 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116008447 CAP-GLY domain containing linker protein 2 isoform ...  2021   0.0  
gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2...  1939   0.0  
gi|4506751 restin isoform a [Homo sapiens]                            834   0.0  
gi|38044112 restin isoform b [Homo sapiens]                           766   0.0  
gi|18496983 CAP-GLY domain containing linker protein 3 [Homo sap...   171   3e-42
gi|31982881 CAP-GLY domain containing linker protein family, mem...   149   2e-35
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   118   3e-26
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   118   3e-26
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   118   3e-26
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   118   3e-26
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   117   4e-26
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...   117   4e-26
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        117   6e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   117   6e-26
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   117   6e-26
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   113   1e-24
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   112   1e-24
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    112   2e-24
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   112   2e-24
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   111   3e-24
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   110   7e-24
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   110   9e-24
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      109   1e-23
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            108   2e-23
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       108   2e-23
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       108   2e-23
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        108   2e-23
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        108   2e-23
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        108   2e-23
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        108   2e-23

>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
            [Homo sapiens]
          Length = 1046

 Score = 2021 bits (5235), Expect = 0.0
 Identities = 1046/1046 (100%), Positives = 1046/1046 (100%)

Query: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
            MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA
Sbjct: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60

Query: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
            PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN
Sbjct: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120

Query: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL 180
            DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL
Sbjct: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL 180

Query: 181  TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE 240
            TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE
Sbjct: 181  TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE 240

Query: 241  TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK 300
            TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK
Sbjct: 241  TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK 300

Query: 301  TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA 360
            TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA
Sbjct: 301  TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA 360

Query: 361  LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL 420
            LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL
Sbjct: 361  LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL 420

Query: 421  VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLE 480
            VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLE
Sbjct: 421  VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLE 480

Query: 481  KAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA 540
            KAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA
Sbjct: 481  KAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA 540

Query: 541  EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ 600
            EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ
Sbjct: 541  EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ 600

Query: 601  QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH 660
            QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH
Sbjct: 601  QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH 660

Query: 661  QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE 720
            QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE
Sbjct: 661  QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE 720

Query: 721  AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEV 780
            AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEV
Sbjct: 721  AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEV 780

Query: 781  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT 840
            ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT
Sbjct: 781  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT 840

Query: 841  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 900
            ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ
Sbjct: 841  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 900

Query: 901  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 960
            ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL
Sbjct: 901  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 960

Query: 961  DKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDK 1020
            DKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDK
Sbjct: 961  DKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDK 1020

Query: 1021 AQTIGNSGSANGIHQQDKAQKQEDKH 1046
            AQTIGNSGSANGIHQQDKAQKQEDKH
Sbjct: 1021 AQTIGNSGSANGIHQQDKAQKQEDKH 1046


>gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2
            [Homo sapiens]
          Length = 1011

 Score = 1939 bits (5022), Expect = 0.0
 Identities = 1011/1046 (96%), Positives = 1011/1046 (96%), Gaps = 35/1046 (3%)

Query: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
            MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA
Sbjct: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60

Query: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
            PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN
Sbjct: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120

Query: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL 180
            DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL
Sbjct: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPL 180

Query: 181  TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE 240
            TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE
Sbjct: 181  TSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGE 240

Query: 241  TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK 300
            TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK
Sbjct: 241  TDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAKAKK 300

Query: 301  TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA 360
            TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA
Sbjct: 301  TKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEA 360

Query: 361  LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL 420
            LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL
Sbjct: 361  LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL 420

Query: 421  VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLE 480
            VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLE                    
Sbjct: 421  VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLE-------------------- 460

Query: 481  KAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA 540
                           LTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA
Sbjct: 461  ---------------LTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA 505

Query: 541  EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ 600
            EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ
Sbjct: 506  EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ 565

Query: 601  QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH 660
            QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH
Sbjct: 566  QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH 625

Query: 661  QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE 720
            QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE
Sbjct: 626  QLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE 685

Query: 721  AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEV 780
            AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEV
Sbjct: 686  AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEV 745

Query: 781  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT 840
            ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT
Sbjct: 746  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVT 805

Query: 841  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 900
            ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ
Sbjct: 806  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 865

Query: 901  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 960
            ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL
Sbjct: 866  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 925

Query: 961  DKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDK 1020
            DKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDK
Sbjct: 926  DKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDK 985

Query: 1021 AQTIGNSGSANGIHQQDKAQKQEDKH 1046
            AQTIGNSGSANGIHQQDKAQKQEDKH
Sbjct: 986  AQTIGNSGSANGIHQQDKAQKQEDKH 1011


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  834 bits (2154), Expect = 0.0
 Identities = 484/1115 (43%), Positives = 700/1115 (62%), Gaps = 96/1115 (8%)

Query: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
            M KPSGLK P +  K  S   +T T       AV A  ++     K SS PSS       
Sbjct: 3    MLKPSGLKAPTKILKPGSTALKTPT-------AVVAPVEKTISSEKASSTPSS------- 48

Query: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
                     E  ++F+ DF VGERVWVNG KPG +Q+LGETQFAPGQWAG+VLD+P+GKN
Sbjct: 49   ---------ETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99

Query: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQN---LSLHSGTAT 177
            DG+V GVRYF+C  L+GIFTRPSKLTR+  AE   +   +  +  A +    S  S  ++
Sbjct: 100  DGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSS 159

Query: 178  PPLTSRVIPLRESV-----------LNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVL 226
             P T   IP + S            +++  KT +ES SNLS++GS+K+GE++L++GDRVL
Sbjct: 160  SPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVL 219

Query: 227  VGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVI 286
            VGGTK GVVR++GETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQC PK+GLFAP+HKV 
Sbjct: 220  VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVT 279

Query: 287  RIGFPSTSPAKAKKT---KRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTET 343
            +IGFPST+PAKAK     + MA   ++L  SPS+SS+SS+SSVASSV  RPSR+GLLTET
Sbjct: 280  KIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTET 339

Query: 344  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
            SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSH+ E+E+E+AL +  H
Sbjct: 340  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGH 399

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQT 463
            +Q+V E E K+ + R +VE+  +EKV+L NQLEEE+RKVEDLQFRVEEESITKGDLETQT
Sbjct: 400  DQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQT 459

Query: 464  QLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQ 523
            +LEHARI ELEQSLL EK +A++L REL D R+ TV+EKSR+++LE++L LR  E+ EL+
Sbjct: 460  KLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELR 519

Query: 524  QCLLHSGPPPPDHPDAAEILR----LRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD 579
            +  L S  P  D   +  +L+    L+E+L     +HQRE   L++ +    + +Q E+ 
Sbjct: 520  R-RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK 578

Query: 580  KLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGP 639
             L  A EK ++E   LK K++ A  EN  ++  WKSKL++  + HQ+++E+LK + + G 
Sbjct: 579  ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 638

Query: 640  GAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGL 699
            G +  E  ELK  +E +++++Q E+ NLQ + D E A H KE EALR KL +  +E    
Sbjct: 639  GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 698

Query: 700  QRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA 759
                R++L+    QH +E+++  ++ ++AE++V ELE L  +   Q + I+    Q+   
Sbjct: 699  LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 758

Query: 760  EKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAV------EALCSSQHTHMIESND 813
            E+K+LD + L++A ++GK E++ LR++L  AE +++ +      E+  +S  T  ++  +
Sbjct: 759  EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 818

Query: 814  I---------------------------------SEETIRTKETVEGLQDKLNKRDKEVT 840
            +                                 SEE +  + +++   +KL++++++  
Sbjct: 819  LKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFN 878

Query: 841  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 900
             L+S  E LR  ++ +E+K +  +++ + L+K K +LE ++  + + + D S QL  ++ 
Sbjct: 879  MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 938

Query: 901  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE--QKLKDDIRGLREKLT 958
            EL  KER + EL++ L +AN ++   ++ +     KAE   +E  +K +++ + L  KL+
Sbjct: 939  ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 998

Query: 959  GLDKEKSLSDQR------RYSLIDPSSAPE----LLRLQHQLMSTEDALRDALDQAQQVE 1008
             L+K+   S  +      RY      +  +    L  LQ  L+ TED L+ A ++   + 
Sbjct: 999  DLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLL 1058

Query: 1009 KLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQE 1043
            + +E +R   DKA+    +  A  I +Q   +K E
Sbjct: 1059 QELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1093



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 98/451 (21%), Positives = 197/451 (43%), Gaps = 54/451 (11%)

Query: 352  SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            S  T + + L+ K++ +E+L       + ++ KA  +   ++K I  +  + EQ   EA 
Sbjct: 931  SQLTKMNDELRLKERDVEEL-------QLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 983

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEE-SITKGDLETQTQLEHARI 470
            +K +  +   + + ++  DL  ++E    + ++L+ R E   S TK   E   Q     +
Sbjct: 984  KKHEEEK---KELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1040

Query: 471  GELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEE-LTLRRGEIEELQQCLLHS 529
             + E  L   + +   LL+EL +  L   A+K++  Q  E+ + +     +E  + L   
Sbjct: 1041 LDTEDKLKGAREENSGLLQELEE--LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1098

Query: 530  GPPPPDHPDAA-EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKY 588
                  +     E+  L+E  L   +E  +   +L  + +K ++ ++ E++ L+ A  + 
Sbjct: 1099 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK-MEEFRKEIETLKQAAAQK 1157

Query: 589  AQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGE 648
            +Q+++ L++       EN+ L +      D + S HQK LE+ ++ LN+       ++ E
Sbjct: 1158 SQQLSALQE-------ENVKLAEELGRSRDEVTS-HQK-LEEERSVLNN-------QLLE 1201

Query: 649  LKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAG---------- 698
            +K        +   E  +LQ    + +A+ + EK+A  EKL+     L G          
Sbjct: 1202 MKKRESKFIKDADEEKASLQKSISITSAL-LTEKDAELEKLRNEVTVLRGENASAKSLHS 1260

Query: 699  -LQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQIS 757
             +Q     +++++     LELQ  +++R+ +    +   + D + R Q   I+FL   I 
Sbjct: 1261 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI- 1319

Query: 758  LAEKKMLDYERLQRAEAQGKQEVESLREKLL 788
                       LQR     K +VE + E  L
Sbjct: 1320 ---------VDLQRKNQDLKMKVEMMSEAAL 1341


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score =  766 bits (1978), Expect = 0.0
 Identities = 457/1111 (41%), Positives = 661/1111 (59%), Gaps = 123/1111 (11%)

Query: 1    MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
            M KPSGLK P +  K  S   +T T       AV A  ++     K SS PSS       
Sbjct: 3    MLKPSGLKAPTKILKPGSTALKTPT-------AVVAPVEKTISSEKASSTPSS------- 48

Query: 61   PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
                     E  ++F+ DF VGERVWVNG KPG +Q+LGETQFAPGQWAG+VLD+P+GKN
Sbjct: 49   ---------ETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99

Query: 121  DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQN---LSLHSGTAT 177
            DG+V GVRYF+C  L+GIFTRPSKLTR+  AE   +   +  +  A +    S  S  ++
Sbjct: 100  DGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSS 159

Query: 178  PPLTSRVIPLRESV-----------LNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVL 226
             P T   IP + S            +++  KT +ES SNLS++GS+K+GE++L++GDRVL
Sbjct: 160  SPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVL 219

Query: 227  VGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVI 286
            VGGTK GVVR++GETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQC PK+GLFAP+HKV 
Sbjct: 220  VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVT 279

Query: 287  RIGFPSTSPAKAKKT---KRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTET 343
            +IGFPST+PAKAK     + MA   ++L  SPS+SS+SS+SSVASSV  RPSR+GLLTET
Sbjct: 280  KIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTET 339

Query: 344  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
            SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSH+ E+E+E+AL +  H
Sbjct: 340  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGH 399

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQT 463
            +Q+V E E K+ + R +VE+  +EKV+L NQLEEE+RKVEDLQFRVEEESITKGDLE  T
Sbjct: 400  DQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVAT 459

Query: 464  QLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQ 523
              E +RI ELE+ L L   +   L R L  N+     + S  L                 
Sbjct: 460  VSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL----------------- 502

Query: 524  QCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRA 583
                             EI  L+E+L     +HQRE   L++ +    + +Q E+  L  
Sbjct: 503  ---------------LQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYT 547

Query: 584  ANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ 643
            A EK ++E   LK K++ A  EN  ++  WKSKL++  + HQ+++E+LK + + G G + 
Sbjct: 548  ATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTET 607

Query: 644  KEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHW 703
             E  ELK  +E +++++Q E+ NLQ + D E A H KE EALR KL +  +E        
Sbjct: 608  AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAI 667

Query: 704  RAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKM 763
            R++L+    QH +E+++  ++ ++AE++V ELE L  +   Q + I+    Q+   E+K+
Sbjct: 668  RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKL 727

Query: 764  LDYERLQRAEAQGKQEVESLREKLLVAENRLQAV------EALCSSQHTHMIESNDI--- 814
            LD + L++A ++GK E++ LR++L  AE +++ +      E+  +S  T  ++  ++   
Sbjct: 728  LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLT 787

Query: 815  ------------------------------SEETIRTKETVEGLQDKLNKRDKEVTALTS 844
                                          SEE +  + +++   +KL++++++   L+S
Sbjct: 788  NLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS 847

Query: 845  QTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLR 904
              E LR  ++ +E+K +  +++ + L+K K +LE ++  + + + D S QL  ++ EL  
Sbjct: 848  DLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL 907

Query: 905  KERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE--QKLKDDIRGLREKLTGLDK 962
            KER + EL++ L +AN ++   ++ +     KAE   +E  +K +++ + L  KL+ L+K
Sbjct: 908  KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEK 967

Query: 963  EKSLSDQR------RYSLIDPSSAPE----LLRLQHQLMSTEDALRDALDQAQQVEKLME 1012
            +   S  +      RY      +  +    L  LQ  L+ TED L+ A ++   + + +E
Sbjct: 968  KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE 1027

Query: 1013 AMRSCPDKAQTIGNSGSANGIHQQDKAQKQE 1043
             +R   DKA+    +  A  I +Q   +K E
Sbjct: 1028 ELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1058



 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 98/451 (21%), Positives = 197/451 (43%), Gaps = 54/451 (11%)

Query: 352  SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            S  T + + L+ K++ +E+L       + ++ KA  +   ++K I  +  + EQ   EA 
Sbjct: 896  SQLTKMNDELRLKERDVEEL-------QLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 948

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEE-SITKGDLETQTQLEHARI 470
            +K +  +   + + ++  DL  ++E    + ++L+ R E   S TK   E   Q     +
Sbjct: 949  KKHEEEK---KELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005

Query: 471  GELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEE-LTLRRGEIEELQQCLLHS 529
             + E  L   + +   LL+EL +  L   A+K++  Q  E+ + +     +E  + L   
Sbjct: 1006 LDTEDKLKGAREENSGLLQELEE--LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1063

Query: 530  GPPPPDHPDAA-EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKY 588
                  +     E+  L+E  L   +E  +   +L  + +K ++ ++ E++ L+ A  + 
Sbjct: 1064 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK-MEEFRKEIETLKQAAAQK 1122

Query: 589  AQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGE 648
            +Q+++ L++       EN+ L +      D + S HQK LE+ ++ LN+       ++ E
Sbjct: 1123 SQQLSALQE-------ENVKLAEELGRSRDEVTS-HQK-LEEERSVLNN-------QLLE 1166

Query: 649  LKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAG---------- 698
            +K        +   E  +LQ    + +A+ + EK+A  EKL+     L G          
Sbjct: 1167 MKKRESKFIKDADEEKASLQKSISITSAL-LTEKDAELEKLRNEVTVLRGENASAKSLHS 1225

Query: 699  -LQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQIS 757
             +Q     +++++     LELQ  +++R+ +    +   + D + R Q   I+FL   I 
Sbjct: 1226 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI- 1284

Query: 758  LAEKKMLDYERLQRAEAQGKQEVESLREKLL 788
                       LQR     K +VE + E  L
Sbjct: 1285 ---------VDLQRKNQDLKMKVEMMSEAAL 1306


>gi|18496983 CAP-GLY domain containing linker protein 3 [Homo
           sapiens]
          Length = 547

 Score =  171 bits (434), Expect = 3e-42
 Identities = 97/230 (42%), Positives = 134/230 (58%), Gaps = 23/230 (10%)

Query: 81  VGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFT 140
           +G+RV ++G K G +++ G T+FA GQW GV LD+P GKNDG+VGGVRYF CP  QG+F 
Sbjct: 296 LGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLFA 355

Query: 141 RPSKLTRQPTAEGSGSDAHSVESLTAQNLSLHSGTATPPLTSRVIPLRESVLNSSVKTGN 200
             SK+++   A  S                  S T+TP  T R+   R +        G 
Sbjct: 356 SVSKISKAVDAPPS------------------SVTSTPR-TPRMDFSRVTGKGRREHKGK 396

Query: 201 ESGSNLSDSGSVK-RGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGK 259
           +   +    GS++ R      +GD+VLV G K G+VR+ G+TDFA G W G+ELD+P GK
Sbjct: 397 KKTPSSPSLGSLQQRDGAKAEVGDQVLVAGQKQGIVRFYGKTDFAPGYWYGIELDQPTGK 456

Query: 260 NDGAVAGTRYFQCPPKFGLFAPIHKVIRIGFPSTSPAK---AKKTKRMAM 306
           +DG+V G RYF CPP+ G+FAP  ++ RIG  + SP     AKK  ++ M
Sbjct: 457 HDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSVGAKKVHQVTM 506



 Score =  106 bits (265), Expect = 1e-22
 Identities = 58/124 (46%), Positives = 75/124 (60%), Gaps = 10/124 (8%)

Query: 210 GSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRY 269
           G++      LRLGDRVL+ G KTG +R+ G T+FA G+W GVELDEP GKNDG+V G RY
Sbjct: 285 GNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRY 344

Query: 270 FQCPPKFGLFAPIHKVIR-IGFPSTSPAKAKKTKRM----AMGVSALTH-----SPSSSS 319
           F CPPK GLFA + K+ + +  P +S     +T RM      G     H     +PSS S
Sbjct: 345 FICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDFSRVTGKGRREHKGKKKTPSSPS 404

Query: 320 ISSV 323
           + S+
Sbjct: 405 LGSL 408



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 51/152 (33%), Positives = 76/152 (50%), Gaps = 11/152 (7%)

Query: 40  EGSPLHKQSSGPSSSPAAAAAPEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLG 99
           +G   HK      SSP+  +  ++ G KA            VG++V V G K G+V++ G
Sbjct: 388 KGRREHKGKKKTPSSPSLGSLQQRDGAKAE-----------VGDQVLVAGQKQGIVRFYG 436

Query: 100 ETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAH 159
           +T FAPG W G+ LD P GK+DG+V GVRYF CP   G+F   S++ R   +  S  D+ 
Sbjct: 437 KTDFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIGGSTDSPGDSV 496

Query: 160 SVESLTAQNLSLHSGTATPPLTSRVIPLRESV 191
             + +    ++    T T   T + I    S+
Sbjct: 497 GAKKVHQVTMTQPKRTFTTVRTPKDIASENSI 528


>gi|31982881 CAP-GLY domain containing linker protein family, member
           4 [Homo sapiens]
          Length = 705

 Score =  149 bits (375), Expect = 2e-35
 Identities = 105/344 (30%), Positives = 163/344 (47%), Gaps = 68/344 (19%)

Query: 81  VGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFT 140
           +G+RV + G K G +++ G T+FA GQWAG+ LD+P GKN+G+VG V+YF+C    GIF 
Sbjct: 285 LGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFA 344

Query: 141 RPSKL----------TRQPTAEGS--------------------GSDAHSVESLTAQNLS 170
             SK+          T  P+ + +                    G      +S +   LS
Sbjct: 345 PLSKISKAKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASESTLS 404

Query: 171 LHSGTATPPLTSRVI---------------------PLRESVLNSSVKTGNES------- 202
           L  G     +T + +                     P +++ ++S+ KT ++S       
Sbjct: 405 LPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRA 464

Query: 203 ----GSNLSDSGSVKRGEKDLRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLG 258
                S+ + + +  R E +LRLG+RVLV G + G +R+ G T+FA G W G+EL++P G
Sbjct: 465 SAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHG 524

Query: 259 KNDGAVAGTRYFQCPPKFGLFAPIHKVIRI--GFPSTSPAKAKKTKRMAMGVSALTHSPS 316
           KNDG+V G +YF C P++G+FAP  +V R+     + S   + K      G      S S
Sbjct: 525 KNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPG---FRRSFS 581

Query: 317 SSSISSVSSVASSVGGRPSRSGLLTETSSR-YARKISGTTALQE 359
           ++S SS   +        S++ L    SS   A  I G+  L E
Sbjct: 582 TTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIEGSVKLHE 625



 Score =  138 bits (348), Expect = 2e-32
 Identities = 95/283 (33%), Positives = 134/283 (47%), Gaps = 18/283 (6%)

Query: 9   PPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAAPEKPGPKA 68
           PPG   K  +       GS SS ++ ++     S   KQ++  S+    + +P      +
Sbjct: 406 PPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSLSSRAS 465

Query: 69  AEVGDDFL---------GDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGK 119
           A +              G+  +GERV V G + G +++ G T FAPG W G+ L+ P GK
Sbjct: 466 AGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGK 525

Query: 120 NDGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQNLS---LHSGTA 176
           NDG+VGGV+YF C    GIF  PS++ R         D  S  S   QN S        +
Sbjct: 526 NDGSVGGVQYFSCSPRYGIFAPPSRVQRVT----DSLDTLSEISSNKQNHSYPGFRRSFS 581

Query: 177 TPPLTSRVIPLRESVLNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVLV-GGTKTGVV 235
           T   +S+    R +  + S      S S+   +G ++ G   L  G +VL+    + G V
Sbjct: 582 TTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGIE-GSVKLHEGSQVLLTSSNEMGTV 640

Query: 236 RYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGL 278
           RYVG TDFA G W G+EL    GKNDG+V   RYF C P  G+
Sbjct: 641 RYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGV 683



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 44/101 (43%), Positives = 66/101 (65%), Gaps = 16/101 (15%)

Query: 219 LRLGDRVLVGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGL 278
           L+LGDRV++ G K G +R+ G T+FA G+W G+ELDEP GKN+G+V   +YF+C PK+G+
Sbjct: 283 LKLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGI 342

Query: 279 FAPIHKVIRIGFPSTSPAKAKKTKRMAMGVSALTHSPSSSS 319
           FAP+ K+        S AK ++          +TH+PS+ +
Sbjct: 343 FAPLSKI--------SKAKGRRKN--------ITHTPSTKA 367



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 27/54 (50%), Positives = 34/54 (62%)

Query: 93  GVVQYLGETQFAPGQWAGVVLDDPVGKNDGAVGGVRYFECPALQGIFTRPSKLT 146
           G V+Y+G T FA G W G+ L    GKNDG+VG  RYF C    G+  RPS++T
Sbjct: 638 GTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVT 691


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  118 bits (295), Expect = 3e-26
 Identities = 170/742 (22%), Positives = 324/742 (43%), Gaps = 84/742 (11%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK---EIALLKAQHEQYVAEAEEKL 414
            +  LKE +Q   QL  E++L + ++   T    E E+    +A  K + E+ + E E +L
Sbjct: 872  ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 931

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVE----DLQFRVEEESITKGDLETQTQLEHARI 470
            +           E+ D   QL+ ER+K+     DL+ ++EEE   +  L+ +     A+I
Sbjct: 932  E-----------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980

Query: 471  GELEQSLLL-----EKAQAERLLRELADNRLTT--VAEKSRVLQLEEELTLRRGEIEELQ 523
             +LE  +L+      K   ER L E   + LTT    E+ +   L +        I EL+
Sbjct: 981  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040

Query: 524  QCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRA 583
              L        +     E+ +L+ +L   + +   +   L+ +  +       + ++L+A
Sbjct: 1041 VRL------KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1094

Query: 584  ANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ 643
            A  +   E+A  K+   +   E  G + + +  LDS  +   K+ E  K  L     A +
Sbjct: 1095 ALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKA-EKQKRDLGEELEALK 1152

Query: 644  KEIGEL---KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAG-L 699
             E+ +     A  + ++ + + E+  L+   D ET  H  + + +R+K  +A EEL   L
Sbjct: 1153 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212

Query: 700  QRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA 759
            ++  RA+  +  ++  LE + A       ELRV    K +VE++ +      L+ Q+   
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENAD---LAGELRVLGQAKQEVEHKKKK-----LEAQVQEL 1264

Query: 760  EKKMLDYERLQRAEAQGK-----QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDI 814
            + K  D ER  RAE   K      EVES+   L  AE +   +    +S  + + ++ ++
Sbjct: 1265 QSKCSDGERA-RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323

Query: 815  SEETIRTKETVE-----------GLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSG 863
             +E  R K  V             LQD+L++  +    L      L  Q+S  + K +  
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383

Query: 864  EKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL------- 916
               V+AL + K+R + E+E ++++  + +     + +   R ++ L++L V L       
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443

Query: 917  --LEANRHS----PGPERDLS------REVHKAEWRIKEQKLKDDIRGLREKLTGLDKEK 964
              LE  +         E+++S      R+  +AE R KE K     R L E L   ++ +
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503

Query: 965  SLSDQRRYSLID-PSSAPELLRLQHQLMSTEDALRDALDQAQ-QVEKLMEAMRSCPD-KA 1021
              +   +  + D  SS  ++ +  H+L  ++ AL   +++ + Q+E+L + +++  D K 
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563

Query: 1022 QTIGNSGSANGIHQQDKAQKQE 1043
            +   N  +  G  ++D   + E
Sbjct: 1564 RLEVNMQALKGQFERDLQARDE 1585



 Score =  109 bits (272), Expect = 2e-23
 Identities = 147/676 (21%), Positives = 294/676 (43%), Gaps = 76/676 (11%)

Query: 367  HIEQLLAERDLERAEVAKATSHICE-VEKEIALLKAQHEQYVAEAEEKLQRARLLVESVR 425
            H+E+   ERDL+  +V  A   +C       A  K Q +    +  ++   A L + + +
Sbjct: 777  HLEE---ERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQ 833

Query: 426  --------KEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSL 477
                    K  + ++ Q EE + K ++LQ   E +   + +L+   Q +H+++ E E++L
Sbjct: 834  WWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ-KHSQLTE-EKNL 891

Query: 478  LLEKAQAE-RLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDH 536
            L E+ QAE  L  E  + R+   A+K  + ++  E+  R  E E+  Q L          
Sbjct: 892  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL---------- 941

Query: 537  PDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAA-------NEKYA 589
               AE  ++ +++L   ++ + E    R K +      +A++ KL          N K +
Sbjct: 942  --QAERKKMAQQMLDLEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 590  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
            +E   L++++   T+ N+   +     L  L + H+  + +L+  L     ++Q E+ +L
Sbjct: 999  KERKLLEERISDLTT-NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKL 1056

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            K  +EG   +   ++ +LQA+         K++E L+  L    +E+A      +   E+
Sbjct: 1057 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1116

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            +   H  +LQE  D  R A        K + + R   + +E LK ++   E  +      
Sbjct: 1117 EG--HISDLQEDLDSERAAR------NKAEKQKRDLGEELEALKTEL---EDTLDSTATQ 1165

Query: 770  QRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIES-NDISEETIRTKETVEGL 828
            Q   A+ +QEV  L++ L       +A       +H   +E   +  E+  R K  ++  
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225

Query: 829  QDKLNKRDKEVTA-----------LTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRL 877
            +  L K + ++             +  + + L AQV  L+SKC  GE+    L  +  +L
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285

Query: 878  EAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKA 937
            + E+E+V+   ++A G+ + +++++      L + + LL E  R              K 
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-------------QKL 1332

Query: 938  EWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDAL 997
                K ++L+++   L+++L   + E   + +R  S ++   +    +LQ    ST +AL
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEAL 1390

Query: 998  RDALDQAQ-QVEKLME 1012
             +   + Q ++E L +
Sbjct: 1391 EEGKKRFQKEIENLTQ 1406



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 159/720 (22%), Positives = 293/720 (40%), Gaps = 79/720 (10%)

Query: 335  SRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK 394
            S    + E   ++A+ +   T   E  K  + ++++     + E A++A     + + ++
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248

Query: 395  EIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESI 454
            E+   K + E  V E + K        E  R E  D  ++L+ E   V  +    E ++I
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDG----ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304

Query: 455  --TKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEEL 512
               K      +QL+  +  EL Q    +K      LR+L + R       S   QL+EE+
Sbjct: 1305 KLAKDVASLSSQLQDTQ--ELLQEETRQKLNVSTKLRQLEEER------NSLQDQLDEEM 1356

Query: 513  TLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALK 572
              ++     +    +          D A  +   E L    K  Q+E   L  +YE+   
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTV---EALEEGKKRFQKEIENLTQQYEEKAA 1413

Query: 573  AYQAEVDKLRAANEKYAQEVAGLK---DKVQQATSENMGLMDNWKSKLDSLASDHQKSLE 629
            AY    DKL     +  QE+  L    D  +Q  S     ++  + K D L ++ +K++ 
Sbjct: 1414 AY----DKLEKTKNRLQQELDDLVVDLDNQRQLVSN----LEKKQRKFDQLLAE-EKNIS 1464

Query: 630  DLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETA--MHVKEKEALRE 687
               A       A+ +E  E KA+     +E  LE     AK +LE    M   E E L  
Sbjct: 1465 SKYADERDRAEAEARE-KETKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVS 1518

Query: 688  KLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRR---DAELRVH-ELEKLDVEYR 743
               +  + +  L++  RA LE Q  + + +L+E +D+ +   DA+LR+   ++ L  ++ 
Sbjct: 1519 SKDDVGKNVHELEKSKRA-LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577

Query: 744  GQAQAIEF--------LKEQISLAEKKMLDYERLQRA-EAQGKQEVES-LREKLLVAENR 793
               QA +         L+ Q+   E ++ D ER QRA  A  K+++E  L++  L A++ 
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSA 1636

Query: 794  LQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQV 853
            ++  E           +  D   E    + + + +     + +K+  +L +    L+  +
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 854  SALESKCKSGEKKVD--------------ALLKEKRRLEAELETVSRKTHDASGQLVLIS 899
            +A E   K  + + +              AL  EKRRLEA +  +  +  +  G +  +S
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756

Query: 900  QELLR----KERSLNELRVLLLEANRHSPGPE------RDLSREVHKAEWRIKEQKLKDD 949
              + +     E+  NEL      A ++    +      ++L  ++H+ E  +K  K K  
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK-SKFKST 1815

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 1009
            I  L  K+  L+ E+   + R       S   +  +L+  L+  ED  + A    +Q EK
Sbjct: 1816 IAALEAKIAQLE-EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 148/607 (24%), Positives = 254/607 (41%), Gaps = 90/607 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L+++  +     S   AL+E  K  Q+ IE L  + + + A   K       +EK    L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-------LEKTKNRL 1425

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERR---KVEDLQFRVEEESITK 456
            + + +  V +    L   R LV ++ K++      L EE+    K  D + R E E+  K
Sbjct: 1426 QQELDDLVVD----LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 457  GD--LETQTQLEHARIG--ELEQSLLLEKAQAERLLRELAD-NRLTTVAEKSRVLQLEEE 511
                L     LE A     ELE++  + KA+ E L+    D  +     EKS+   LE +
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK-RALETQ 1540

Query: 512  LTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLR------------ERLLSASKEHQRE 559
            +   + ++EEL+           D   A E  +LR            ER L A  E   E
Sbjct: 1541 MEEMKTQLEELE-----------DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589

Query: 560  SGVLRDKYEKALKAYQAEVD---KLRAANEKYAQEVAG-LKDKVQQATSENMGLMDNWKS 615
                R + ++ L  Y+ E++   K RA      +++ G LKD   QA S   G  +  K 
Sbjct: 1590 K---RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1646

Query: 616  --KLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDL 673
              KL +   D Q+ LED +A+        + EI       E  K    LE   +Q + DL
Sbjct: 1647 LRKLQAQMKDFQRELEDARAS--------RDEI--FATAKENEKKAKSLEADLMQLQEDL 1696

Query: 674  ETAMHVK-----EKEALREKLQEAQEELAGLQRHWR------AQLEVQASQHRLELQEAQ 722
              A   +     EKE L E+L  +      LQ   R      AQLE +  + +  ++   
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756

Query: 723  DQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLD--YERLQRAEAQGKQEV 780
            D+ R A  +  +L       R  AQ  E  ++Q+    K++    +E     +++ K  +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 781  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQD--KLNKRDKE 838
             +L  K+   E +++  EA      T  ++  D      + KE +  ++D  K+ ++ KE
Sbjct: 1817 AALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDK-----KLKEILLQVEDERKMAEQYKE 1870

Query: 839  VTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLI 898
                  Q E   A+V  L+ + +  E++   +   +R+L+ EL+  + ++++A G+ V  
Sbjct: 1871 ------QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT-ESNEAMGREVNA 1923

Query: 899  SQELLRK 905
             +  LR+
Sbjct: 1924 LKSKLRR 1930



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 115/517 (22%), Positives = 218/517 (42%), Gaps = 41/517 (7%)

Query: 361  LKEKQQHIEQLLAERDLERAEVA----KATSHICEVE-KEIALLKAQHEQYVAEAEEKLQ 415
            L++KQ+  +QLLAE     ++ A    +A +   E E K ++L +A  E    EA+E+L+
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE--ALEAKEELE 1503

Query: 416  RARLLV----ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
            R   ++    E +   K D+   + E  +    L+ ++EE      +LE + Q       
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGP 531
             LE ++   K Q ER L+   +       EK R LQ +        E E  Q+ L  +  
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQN----EEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619

Query: 532  PPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQE 591
               +     ++  L  +  SA K  +     LR K +  +K +Q E++  RA+ ++    
Sbjct: 1620 KKLE----GDLKDLELQADSAIKGREEAIKQLR-KLQAQMKDFQRELEDARASRDEIFAT 1674

Query: 592  VAGLKDKVQQATSENMGLMDNWKS--KLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
                + K +   ++ M L ++  +  +    A   ++ L +  A+  SG  A Q E   L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            +A +  ++ E + E GN++A  D            +R+  Q+A++    L     A    
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSD-----------RVRKATQQAEQLSNEL-----ATERS 1778

Query: 710  QASQHRLELQEAQDQRRDAELRVHELE-KLDVEYRGQAQAIEFLKEQISLAEKKMLDYER 768
             A ++    Q+ + Q ++   ++HE+E  +  +++    A+E    Q  L E+   +   
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ--LEEQVEQEARE 1836

Query: 769  LQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGL 828
             Q A    KQ+ + L+E LL  E+  +  E               +  +    +E  + +
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896

Query: 829  QDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEK 865
                 K  +E+   T   E +  +V+AL+SK + G +
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 66/293 (22%), Positives = 123/293 (41%), Gaps = 51/293 (17%)

Query: 333  RPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEV 392
            R SR  +   T+    +K     A    L+E     E+   + DLE+ E+A+  +     
Sbjct: 1665 RASRDEIFA-TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRAR----LLVESVRK---EKVDLSNQLEEER------ 439
               +   K + E  +A+ EE+L+  +     + + VRK   +   LSN+L  ER      
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 440  --------RKVEDLQFRVEE-ESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRE 490
                    R+ ++L+ ++ E E   K   ++      A+I +LE+ +  E  + +   + 
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 491  L--ADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRER 548
            L   D +L     K  +LQ+E+E  +     E+ ++               A + +L+ +
Sbjct: 1844 LKQKDKKL-----KEILLQVEDERKMAEQYKEQAEK-------------GNARVKQLKRQ 1885

Query: 549  LLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQ 601
            L  A +E QR +   R          Q E+D+   +NE   +EV  LK K+++
Sbjct: 1886 LEEAEEESQRINANRR--------KLQRELDEATESNEAMGREVNALKSKLRR 1930



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 51/219 (23%), Positives = 99/219 (45%), Gaps = 31/219 (14%)

Query: 326  VASSVGGRPSRSGLLTETSSRYAR-------KISGTTALQEALKEKQQHIEQLLAERDLE 378
            +ASS+ GR +         +R A+       +     A+ + +++  Q  EQL  E   E
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776

Query: 379  RAEVAKATSHICEVEKEIALL-----------KAQHEQYVAEAEEKLQRARLLVESVRKE 427
            R+   K  S   ++E++   L           K++ +  +A  E K+ +    VE   +E
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836

Query: 428  KVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAE-- 485
            K   +  L+++ +K++++  +VE+E       + Q +  +AR+ +L++   LE+A+ E  
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ--LEEAEEESQ 1894

Query: 486  -------RLLRELADNRLTTVAEKSRVLQLEEELTLRRG 517
                   +L REL +   +  A    V  L+ +  LRRG
Sbjct: 1895 RINANRRKLQRELDEATESNEAMGREVNALKSK--LRRG 1931


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  118 bits (295), Expect = 3e-26
 Identities = 170/742 (22%), Positives = 324/742 (43%), Gaps = 84/742 (11%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK---EIALLKAQHEQYVAEAEEKL 414
            +  LKE +Q   QL  E++L + ++   T    E E+    +A  K + E+ + E E +L
Sbjct: 879  ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 938

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVE----DLQFRVEEESITKGDLETQTQLEHARI 470
            +           E+ D   QL+ ER+K+     DL+ ++EEE   +  L+ +     A+I
Sbjct: 939  E-----------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987

Query: 471  GELEQSLLL-----EKAQAERLLRELADNRLTT--VAEKSRVLQLEEELTLRRGEIEELQ 523
             +LE  +L+      K   ER L E   + LTT    E+ +   L +        I EL+
Sbjct: 988  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047

Query: 524  QCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRA 583
              L        +     E+ +L+ +L   + +   +   L+ +  +       + ++L+A
Sbjct: 1048 VRL------KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1101

Query: 584  ANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ 643
            A  +   E+A  K+   +   E  G + + +  LDS  +   K+ E  K  L     A +
Sbjct: 1102 ALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKA-EKQKRDLGEELEALK 1159

Query: 644  KEIGEL---KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAG-L 699
             E+ +     A  + ++ + + E+  L+   D ET  H  + + +R+K  +A EEL   L
Sbjct: 1160 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219

Query: 700  QRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA 759
            ++  RA+  +  ++  LE + A       ELRV    K +VE++ +      L+ Q+   
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENAD---LAGELRVLGQAKQEVEHKKKK-----LEAQVQEL 1271

Query: 760  EKKMLDYERLQRAEAQGK-----QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDI 814
            + K  D ER  RAE   K      EVES+   L  AE +   +    +S  + + ++ ++
Sbjct: 1272 QSKCSDGERA-RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330

Query: 815  SEETIRTKETVE-----------GLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSG 863
             +E  R K  V             LQD+L++  +    L      L  Q+S  + K +  
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390

Query: 864  EKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL------- 916
               V+AL + K+R + E+E ++++  + +     + +   R ++ L++L V L       
Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450

Query: 917  --LEANRHS----PGPERDLS------REVHKAEWRIKEQKLKDDIRGLREKLTGLDKEK 964
              LE  +         E+++S      R+  +AE R KE K     R L E L   ++ +
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510

Query: 965  SLSDQRRYSLID-PSSAPELLRLQHQLMSTEDALRDALDQAQ-QVEKLMEAMRSCPD-KA 1021
              +   +  + D  SS  ++ +  H+L  ++ AL   +++ + Q+E+L + +++  D K 
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570

Query: 1022 QTIGNSGSANGIHQQDKAQKQE 1043
            +   N  +  G  ++D   + E
Sbjct: 1571 RLEVNMQALKGQFERDLQARDE 1592



 Score =  109 bits (272), Expect = 2e-23
 Identities = 147/676 (21%), Positives = 294/676 (43%), Gaps = 76/676 (11%)

Query: 367  HIEQLLAERDLERAEVAKATSHICE-VEKEIALLKAQHEQYVAEAEEKLQRARLLVESVR 425
            H+E+   ERDL+  +V  A   +C       A  K Q +    +  ++   A L + + +
Sbjct: 784  HLEE---ERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQ 840

Query: 426  --------KEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSL 477
                    K  + ++ Q EE + K ++LQ   E +   + +L+   Q +H+++ E E++L
Sbjct: 841  WWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ-KHSQLTE-EKNL 898

Query: 478  LLEKAQAE-RLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDH 536
            L E+ QAE  L  E  + R+   A+K  + ++  E+  R  E E+  Q L          
Sbjct: 899  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL---------- 948

Query: 537  PDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAA-------NEKYA 589
               AE  ++ +++L   ++ + E    R K +      +A++ KL          N K +
Sbjct: 949  --QAERKKMAQQMLDLEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 590  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
            +E   L++++   T+ N+   +     L  L + H+  + +L+  L     ++Q E+ +L
Sbjct: 1006 KERKLLEERISDLTT-NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKL 1063

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            K  +EG   +   ++ +LQA+         K++E L+  L    +E+A      +   E+
Sbjct: 1064 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            +   H  +LQE  D  R A        K + + R   + +E LK ++   E  +      
Sbjct: 1124 EG--HISDLQEDLDSERAAR------NKAEKQKRDLGEELEALKTEL---EDTLDSTATQ 1172

Query: 770  QRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIES-NDISEETIRTKETVEGL 828
            Q   A+ +QEV  L++ L       +A       +H   +E   +  E+  R K  ++  
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232

Query: 829  QDKLNKRDKEVTA-----------LTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRL 877
            +  L K + ++             +  + + L AQV  L+SKC  GE+    L  +  +L
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292

Query: 878  EAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKA 937
            + E+E+V+   ++A G+ + +++++      L + + LL E  R              K 
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-------------QKL 1339

Query: 938  EWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDAL 997
                K ++L+++   L+++L   + E   + +R  S ++   +    +LQ    ST +AL
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEAL 1397

Query: 998  RDALDQAQ-QVEKLME 1012
             +   + Q ++E L +
Sbjct: 1398 EEGKKRFQKEIENLTQ 1413



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 159/720 (22%), Positives = 293/720 (40%), Gaps = 79/720 (10%)

Query: 335  SRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK 394
            S    + E   ++A+ +   T   E  K  + ++++     + E A++A     + + ++
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255

Query: 395  EIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESI 454
            E+   K + E  V E + K        E  R E  D  ++L+ E   V  +    E ++I
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDG----ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311

Query: 455  --TKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEEL 512
               K      +QL+  +  EL Q    +K      LR+L + R       S   QL+EE+
Sbjct: 1312 KLAKDVASLSSQLQDTQ--ELLQEETRQKLNVSTKLRQLEEER------NSLQDQLDEEM 1363

Query: 513  TLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALK 572
              ++     +    +          D A  +   E L    K  Q+E   L  +YE+   
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTV---EALEEGKKRFQKEIENLTQQYEEKAA 1420

Query: 573  AYQAEVDKLRAANEKYAQEVAGLK---DKVQQATSENMGLMDNWKSKLDSLASDHQKSLE 629
            AY    DKL     +  QE+  L    D  +Q  S     ++  + K D L ++ +K++ 
Sbjct: 1421 AY----DKLEKTKNRLQQELDDLVVDLDNQRQLVSN----LEKKQRKFDQLLAE-EKNIS 1471

Query: 630  DLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETA--MHVKEKEALRE 687
               A       A+ +E  E KA+     +E  LE     AK +LE    M   E E L  
Sbjct: 1472 SKYADERDRAEAEARE-KETKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVS 1525

Query: 688  KLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRR---DAELRVH-ELEKLDVEYR 743
               +  + +  L++  RA LE Q  + + +L+E +D+ +   DA+LR+   ++ L  ++ 
Sbjct: 1526 SKDDVGKNVHELEKSKRA-LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584

Query: 744  GQAQAIEF--------LKEQISLAEKKMLDYERLQRA-EAQGKQEVES-LREKLLVAENR 793
               QA +         L+ Q+   E ++ D ER QRA  A  K+++E  L++  L A++ 
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSA 1643

Query: 794  LQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQV 853
            ++  E           +  D   E    + + + +     + +K+  +L +    L+  +
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 854  SALESKCKSGEKKVD--------------ALLKEKRRLEAELETVSRKTHDASGQLVLIS 899
            +A E   K  + + +              AL  EKRRLEA +  +  +  +  G +  +S
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763

Query: 900  QELLR----KERSLNELRVLLLEANRHSPGPE------RDLSREVHKAEWRIKEQKLKDD 949
              + +     E+  NEL      A ++    +      ++L  ++H+ E  +K  K K  
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK-SKFKST 1822

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 1009
            I  L  K+  L+ E+   + R       S   +  +L+  L+  ED  + A    +Q EK
Sbjct: 1823 IAALEAKIAQLE-EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 148/607 (24%), Positives = 254/607 (41%), Gaps = 90/607 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L+++  +     S   AL+E  K  Q+ IE L  + + + A   K       +EK    L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-------LEKTKNRL 1432

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERR---KVEDLQFRVEEESITK 456
            + + +  V +    L   R LV ++ K++      L EE+    K  D + R E E+  K
Sbjct: 1433 QQELDDLVVD----LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 457  GD--LETQTQLEHARIG--ELEQSLLLEKAQAERLLRELAD-NRLTTVAEKSRVLQLEEE 511
                L     LE A     ELE++  + KA+ E L+    D  +     EKS+   LE +
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK-RALETQ 1547

Query: 512  LTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLR------------ERLLSASKEHQRE 559
            +   + ++EEL+           D   A E  +LR            ER L A  E   E
Sbjct: 1548 MEEMKTQLEELE-----------DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596

Query: 560  SGVLRDKYEKALKAYQAEVD---KLRAANEKYAQEVAG-LKDKVQQATSENMGLMDNWKS 615
                R + ++ L  Y+ E++   K RA      +++ G LKD   QA S   G  +  K 
Sbjct: 1597 K---RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1653

Query: 616  --KLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDL 673
              KL +   D Q+ LED +A+        + EI       E  K    LE   +Q + DL
Sbjct: 1654 LRKLQAQMKDFQRELEDARAS--------RDEI--FATAKENEKKAKSLEADLMQLQEDL 1703

Query: 674  ETAMHVK-----EKEALREKLQEAQEELAGLQRHWR------AQLEVQASQHRLELQEAQ 722
              A   +     EKE L E+L  +      LQ   R      AQLE +  + +  ++   
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763

Query: 723  DQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLD--YERLQRAEAQGKQEV 780
            D+ R A  +  +L       R  AQ  E  ++Q+    K++    +E     +++ K  +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 781  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQD--KLNKRDKE 838
             +L  K+   E +++  EA      T  ++  D      + KE +  ++D  K+ ++ KE
Sbjct: 1824 AALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDK-----KLKEILLQVEDERKMAEQYKE 1877

Query: 839  VTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLI 898
                  Q E   A+V  L+ + +  E++   +   +R+L+ EL+  + ++++A G+ V  
Sbjct: 1878 ------QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT-ESNEAMGREVNA 1930

Query: 899  SQELLRK 905
             +  LR+
Sbjct: 1931 LKSKLRR 1937



 Score = 79.7 bits (195), Expect = 1e-14
 Identities = 115/517 (22%), Positives = 218/517 (42%), Gaps = 41/517 (7%)

Query: 361  LKEKQQHIEQLLAERDLERAEVA----KATSHICEVE-KEIALLKAQHEQYVAEAEEKLQ 415
            L++KQ+  +QLLAE     ++ A    +A +   E E K ++L +A  E    EA+E+L+
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE--ALEAKEELE 1510

Query: 416  RARLLV----ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
            R   ++    E +   K D+   + E  +    L+ ++EE      +LE + Q       
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGP 531
             LE ++   K Q ER L+   +       EK R LQ +        E E  Q+ L  +  
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQN----EEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626

Query: 532  PPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQE 591
               +     ++  L  +  SA K  +     LR K +  +K +Q E++  RA+ ++    
Sbjct: 1627 KKLE----GDLKDLELQADSAIKGREEAIKQLR-KLQAQMKDFQRELEDARASRDEIFAT 1681

Query: 592  VAGLKDKVQQATSENMGLMDNWKS--KLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
                + K +   ++ M L ++  +  +    A   ++ L +  A+  SG  A Q E   L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            +A +  ++ E + E GN++A  D            +R+  Q+A++    L     A    
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSD-----------RVRKATQQAEQLSNEL-----ATERS 1785

Query: 710  QASQHRLELQEAQDQRRDAELRVHELE-KLDVEYRGQAQAIEFLKEQISLAEKKMLDYER 768
             A ++    Q+ + Q ++   ++HE+E  +  +++    A+E    Q  L E+   +   
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ--LEEQVEQEARE 1843

Query: 769  LQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGL 828
             Q A    KQ+ + L+E LL  E+  +  E               +  +    +E  + +
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903

Query: 829  QDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEK 865
                 K  +E+   T   E +  +V+AL+SK + G +
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 66/293 (22%), Positives = 123/293 (41%), Gaps = 51/293 (17%)

Query: 333  RPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEV 392
            R SR  +   T+    +K     A    L+E     E+   + DLE+ E+A+  +     
Sbjct: 1672 RASRDEIFA-TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRAR----LLVESVRK---EKVDLSNQLEEER------ 439
               +   K + E  +A+ EE+L+  +     + + VRK   +   LSN+L  ER      
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 440  --------RKVEDLQFRVEE-ESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRE 490
                    R+ ++L+ ++ E E   K   ++      A+I +LE+ +  E  + +   + 
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 491  L--ADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRER 548
            L   D +L     K  +LQ+E+E  +     E+ ++               A + +L+ +
Sbjct: 1851 LKQKDKKL-----KEILLQVEDERKMAEQYKEQAEK-------------GNARVKQLKRQ 1892

Query: 549  LLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQ 601
            L  A +E QR +   R          Q E+D+   +NE   +EV  LK K+++
Sbjct: 1893 LEEAEEESQRINANRR--------KLQRELDEATESNEAMGREVNALKSKLRR 1937



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 51/219 (23%), Positives = 99/219 (45%), Gaps = 31/219 (14%)

Query: 326  VASSVGGRPSRSGLLTETSSRYAR-------KISGTTALQEALKEKQQHIEQLLAERDLE 378
            +ASS+ GR +         +R A+       +     A+ + +++  Q  EQL  E   E
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783

Query: 379  RAEVAKATSHICEVEKEIALL-----------KAQHEQYVAEAEEKLQRARLLVESVRKE 427
            R+   K  S   ++E++   L           K++ +  +A  E K+ +    VE   +E
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843

Query: 428  KVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAE-- 485
            K   +  L+++ +K++++  +VE+E       + Q +  +AR+ +L++   LE+A+ E  
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ--LEEAEEESQ 1901

Query: 486  -------RLLRELADNRLTTVAEKSRVLQLEEELTLRRG 517
                   +L REL +   +  A    V  L+ +  LRRG
Sbjct: 1902 RINANRRKLQRELDEATESNEAMGREVNALKSK--LRRG 1938


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  118 bits (295), Expect = 3e-26
 Identities = 170/742 (22%), Positives = 324/742 (43%), Gaps = 84/742 (11%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK---EIALLKAQHEQYVAEAEEKL 414
            +  LKE +Q   QL  E++L + ++   T    E E+    +A  K + E+ + E E +L
Sbjct: 879  ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 938

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVE----DLQFRVEEESITKGDLETQTQLEHARI 470
            +           E+ D   QL+ ER+K+     DL+ ++EEE   +  L+ +     A+I
Sbjct: 939  E-----------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 987

Query: 471  GELEQSLLL-----EKAQAERLLRELADNRLTT--VAEKSRVLQLEEELTLRRGEIEELQ 523
             +LE  +L+      K   ER L E   + LTT    E+ +   L +        I EL+
Sbjct: 988  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047

Query: 524  QCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRA 583
              L        +     E+ +L+ +L   + +   +   L+ +  +       + ++L+A
Sbjct: 1048 VRL------KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1101

Query: 584  ANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ 643
            A  +   E+A  K+   +   E  G + + +  LDS  +   K+ E  K  L     A +
Sbjct: 1102 ALARLDDEIA-QKNNALKKIRELEGHISDLQEDLDSERAARNKA-EKQKRDLGEELEALK 1159

Query: 644  KEIGEL---KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELA-GL 699
             E+ +     A  + ++ + + E+  L+   D ET  H  + + +R+K  +A EEL   L
Sbjct: 1160 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1219

Query: 700  QRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA 759
            ++  RA+  +  ++  LE + A       ELRV    K +VE++ +      L+ Q+   
Sbjct: 1220 EQFKRAKANLDKNKQTLEKENAD---LAGELRVLGQAKQEVEHKKKK-----LEAQVQEL 1271

Query: 760  EKKMLDYERLQRAEAQGK-----QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDI 814
            + K  D ER  RAE   K      EVES+   L  AE +   +    +S  + + ++ ++
Sbjct: 1272 QSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1330

Query: 815  SEETIRTK-----------ETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSG 863
             +E  R K           E    LQD+L++  +    L      L  Q+S  + K +  
Sbjct: 1331 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1390

Query: 864  EKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL------- 916
               V+AL + K+R + E+E ++++  + +     + +   R ++ L++L V L       
Sbjct: 1391 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1450

Query: 917  --LEANRHS----PGPERDLS------REVHKAEWRIKEQKLKDDIRGLREKLTGLDKEK 964
              LE  +         E+++S      R+  +AE R KE K     R L E L   ++ +
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510

Query: 965  SLSDQRRYSLID-PSSAPELLRLQHQLMSTEDALRDALDQAQ-QVEKLMEAMRSCPD-KA 1021
              +   +  + D  SS  ++ +  H+L  ++ AL   +++ + Q+E+L + +++  D K 
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570

Query: 1022 QTIGNSGSANGIHQQDKAQKQE 1043
            +   N  +  G  ++D   + E
Sbjct: 1571 RLEVNMQALKGQFERDLQARDE 1592



 Score =  109 bits (272), Expect = 2e-23
 Identities = 147/676 (21%), Positives = 294/676 (43%), Gaps = 76/676 (11%)

Query: 367  HIEQLLAERDLERAEVAKATSHICE-VEKEIALLKAQHEQYVAEAEEKLQRARLLVESVR 425
            H+E+   ERDL+  +V  A   +C       A  K Q +    +  ++   A L + + +
Sbjct: 784  HLEE---ERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQ 840

Query: 426  --------KEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSL 477
                    K  + ++ Q EE + K ++LQ   E +   + +L+   Q +H+++ E E++L
Sbjct: 841  WWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ-KHSQLTE-EKNL 898

Query: 478  LLEKAQAE-RLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDH 536
            L E+ QAE  L  E  + R+   A+K  + ++  E+  R  E E+  Q L          
Sbjct: 899  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL---------- 948

Query: 537  PDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAA-------NEKYA 589
               AE  ++ +++L   ++ + E    R K +      +A++ KL          N K +
Sbjct: 949  --QAERKKMAQQMLDLEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005

Query: 590  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
            +E   L++++   T+ N+   +     L  L + H+  + +L+  L     ++Q E+ +L
Sbjct: 1006 KERKLLEERISDLTT-NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKL 1063

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            K  +EG   +   ++ +LQA+         K++E L+  L    +E+A      +   E+
Sbjct: 1064 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1123

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            +   H  +LQE  D  R A        K + + R   + +E LK ++   E  +      
Sbjct: 1124 EG--HISDLQEDLDSERAAR------NKAEKQKRDLGEELEALKTEL---EDTLDSTATQ 1172

Query: 770  QRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIES-NDISEETIRTKETVEGL 828
            Q   A+ +QEV  L++ L       +A       +H   +E   +  E+  R K  ++  
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232

Query: 829  QDKLNKRDKEVTA-----------LTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRL 877
            +  L K + ++             +  + + L AQV  L+SKC  GE+    L  +  +L
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292

Query: 878  EAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKA 937
            + E+E+V+   ++A G+ + +++++      L + + LL E  R              K 
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-------------QKL 1339

Query: 938  EWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDAL 997
                K ++L+++   L+++L   + E   + +R  S ++   +    +LQ    ST +AL
Sbjct: 1340 NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEAL 1397

Query: 998  RDALDQAQ-QVEKLME 1012
             +   + Q ++E L +
Sbjct: 1398 EEGKKRFQKEIENLTQ 1413



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 159/720 (22%), Positives = 293/720 (40%), Gaps = 79/720 (10%)

Query: 335  SRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK 394
            S    + E   ++A+ +   T   E  K  + ++++     + E A++A     + + ++
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255

Query: 395  EIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESI 454
            E+   K + E  V E + K        E  R E  D  ++L+ E   V  +    E ++I
Sbjct: 1256 EVEHKKKKLEAQVQELQSKCSDG----ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311

Query: 455  --TKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEEL 512
               K      +QL+  +  EL Q    +K      LR+L + R       S   QL+EE+
Sbjct: 1312 KLAKDVASLSSQLQDTQ--ELLQEETRQKLNVSTKLRQLEEER------NSLQDQLDEEM 1363

Query: 513  TLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALK 572
              ++     +    +          D A  +   E L    K  Q+E   L  +YE+   
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTV---EALEEGKKRFQKEIENLTQQYEEKAA 1420

Query: 573  AYQAEVDKLRAANEKYAQEVAGLK---DKVQQATSENMGLMDNWKSKLDSLASDHQKSLE 629
            AY    DKL     +  QE+  L    D  +Q  S     ++  + K D L ++ +K++ 
Sbjct: 1421 AY----DKLEKTKNRLQQELDDLVVDLDNQRQLVSN----LEKKQRKFDQLLAE-EKNIS 1471

Query: 630  DLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETA--MHVKEKEALRE 687
               A       A+ +E  E KA+     +E  LE     AK +LE    M   E E L  
Sbjct: 1472 SKYADERDRAEAEARE-KETKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVS 1525

Query: 688  KLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRR---DAELRVH-ELEKLDVEYR 743
               +  + +  L++  RA LE Q  + + +L+E +D+ +   DA+LR+   ++ L  ++ 
Sbjct: 1526 SKDDVGKNVHELEKSKRA-LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584

Query: 744  GQAQAIEF--------LKEQISLAEKKMLDYERLQRA-EAQGKQEVES-LREKLLVAENR 793
               QA +         L+ Q+   E ++ D ER QRA  A  K+++E  L++  L A++ 
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSA 1643

Query: 794  LQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQV 853
            ++  E           +  D   E    + + + +     + +K+  +L +    L+  +
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703

Query: 854  SALESKCKSGEKKVD--------------ALLKEKRRLEAELETVSRKTHDASGQLVLIS 899
            +A E   K  + + +              AL  EKRRLEA +  +  +  +  G +  +S
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763

Query: 900  QELLR----KERSLNELRVLLLEANRHSPGPE------RDLSREVHKAEWRIKEQKLKDD 949
              + +     E+  NEL      A ++    +      ++L  ++H+ E  +K  K K  
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK-SKFKST 1822

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 1009
            I  L  K+  L+ E+   + R       S   +  +L+  L+  ED  + A    +Q EK
Sbjct: 1823 IAALEAKIAQLE-EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 148/606 (24%), Positives = 253/606 (41%), Gaps = 90/606 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L+++  +     S   AL+E  K  Q+ IE L  + + + A   K       +EK    L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-------LEKTKNRL 1432

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERR---KVEDLQFRVEEESITK 456
            + + +  V +    L   R LV ++ K++      L EE+    K  D + R E E+  K
Sbjct: 1433 QQELDDLVVD----LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 457  GD--LETQTQLEHARIG--ELEQSLLLEKAQAERLLRELAD-NRLTTVAEKSRVLQLEEE 511
                L     LE A     ELE++  + KA+ E L+    D  +     EKS+   LE +
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK-RALETQ 1547

Query: 512  LTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLR------------ERLLSASKEHQRE 559
            +   + ++EEL+           D   A E  +LR            ER L A  E   E
Sbjct: 1548 MEEMKTQLEELE-----------DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596

Query: 560  SGVLRDKYEKALKAYQAEVD---KLRAANEKYAQEVAG-LKDKVQQATSENMGLMDNWKS 615
                R + ++ L  Y+ E++   K RA      +++ G LKD   QA S   G  +  K 
Sbjct: 1597 K---RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1653

Query: 616  --KLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDL 673
              KL +   D Q+ LED +A+        + EI       E  K    LE   +Q + DL
Sbjct: 1654 LRKLQAQMKDFQRELEDARAS--------RDEI--FATAKENEKKAKSLEADLMQLQEDL 1703

Query: 674  ETAMHVK-----EKEALREKLQEAQEELAGLQRHWR------AQLEVQASQHRLELQEAQ 722
              A   +     EKE L E+L  +      LQ   R      AQLE +  + +  ++   
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763

Query: 723  DQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLD--YERLQRAEAQGKQEV 780
            D+ R A  +  +L       R  AQ  E  ++Q+    K++    +E     +++ K  +
Sbjct: 1764 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1823

Query: 781  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQD--KLNKRDKE 838
             +L  K+   E +++  EA      T  ++  D      + KE +  ++D  K+ ++ KE
Sbjct: 1824 AALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDK-----KLKEILLQVEDERKMAEQYKE 1877

Query: 839  VTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLI 898
                  Q E   A+V  L+ + +  E++   +   +R+L+ EL+  + ++++A G+ V  
Sbjct: 1878 ------QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT-ESNEAMGREVNA 1930

Query: 899  SQELLR 904
             +  LR
Sbjct: 1931 LKSKLR 1936



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 69/318 (21%), Positives = 141/318 (44%), Gaps = 28/318 (8%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQR 416
            L+  LK+ +   +  +  R+    ++ K  + + + ++E+   +A  ++  A A+E  ++
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1688

Query: 417  ARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESIT-----KGDLETQTQLEHARIG 471
            A+ L   + + + DL+    E  RK  DL+     E +      +  L+ + +   ARI 
Sbjct: 1689 AKSLEADLMQLQEDLA--AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1746

Query: 472  ELEQSLLLEKA--------------QAERLLRELADNRLTTVAEKSRVLQLEEELTLRRG 517
            +LE+ L  E+               QAE+L  ELA  R T    +S   QLE +    R 
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1806

Query: 518  EIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAE 577
            ++ E++   + S          A+I +L E++   ++E Q  +  L+ K +K LK    +
Sbjct: 1807 KLHEMEGA-VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK-DKKLKEILLQ 1864

Query: 578  VDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNS 637
            V+  R   E+Y ++      +V+Q   +    ++  + +   + ++ +K   +L     S
Sbjct: 1865 VEDERKMAEQYKEQAEKGNARVKQLKRQ----LEEAEEESQRINANRRKLQRELDEATES 1920

Query: 638  GPGAQQKEIGELKAVMEG 655
               A  +E+  LK+ + G
Sbjct: 1921 NE-AMGREVNALKSKLRG 1937



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 66/292 (22%), Positives = 122/292 (41%), Gaps = 51/292 (17%)

Query: 333  RPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEV 392
            R SR  +   T+    +K     A    L+E     E+   + DLE+ E+A+  +     
Sbjct: 1672 RASRDEIFA-TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRAR----LLVESVRK---EKVDLSNQLEEER------ 439
               +   K + E  +A+ EE+L+  +     + + VRK   +   LSN+L  ER      
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790

Query: 440  --------RKVEDLQFRVEE-ESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRE 490
                    R+ ++L+ ++ E E   K   ++      A+I +LE+ +  E  + +   + 
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850

Query: 491  L--ADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRER 548
            L   D +L     K  +LQ+E+E  +     E+ ++               A + +L+ +
Sbjct: 1851 LKQKDKKL-----KEILLQVEDERKMAEQYKEQAEK-------------GNARVKQLKRQ 1892

Query: 549  LLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ 600
            L  A +E QR +   R          Q E+D+   +NE   +EV  LK K++
Sbjct: 1893 LEEAEEESQRINANRR--------KLQRELDEATESNEAMGREVNALKSKLR 1936



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 50/228 (21%), Positives = 99/228 (43%), Gaps = 27/228 (11%)

Query: 326  VASSVGGRPSRSGLLTETSSRYAR-------KISGTTALQEALKEKQQHIEQLLAERDLE 378
            +ASS+ GR +         +R A+       +     A+ + +++  Q  EQL  E   E
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783

Query: 379  RAEVAKATSHICEVEKEIALL-----------KAQHEQYVAEAEEKLQRARLLVESVRKE 427
            R+   K  S   ++E++   L           K++ +  +A  E K+ +    VE   +E
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1843

Query: 428  KVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERL 487
            K   +  L+++ +K++++  +VE+E       + Q +  +AR+ +L++ L     +AE  
Sbjct: 1844 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL----EEAEEE 1899

Query: 488  LRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPD 535
             + +  NR     E     +  E +     E+  L+  L   GPPP +
Sbjct: 1900 SQRINANRRKLQRELDEATESNEAM---GREVNALKSKL--RGPPPQE 1942


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  118 bits (295), Expect = 3e-26
 Identities = 170/742 (22%), Positives = 324/742 (43%), Gaps = 84/742 (11%)

Query: 358  QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK---EIALLKAQHEQYVAEAEEKL 414
            +  LKE +Q   QL  E++L + ++   T    E E+    +A  K + E+ + E E +L
Sbjct: 872  ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 931

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVE----DLQFRVEEESITKGDLETQTQLEHARI 470
            +           E+ D   QL+ ER+K+     DL+ ++EEE   +  L+ +     A+I
Sbjct: 932  E-----------EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI 980

Query: 471  GELEQSLLL-----EKAQAERLLRELADNRLTT--VAEKSRVLQLEEELTLRRGEIEELQ 523
             +LE  +L+      K   ER L E   + LTT    E+ +   L +        I EL+
Sbjct: 981  KKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040

Query: 524  QCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRA 583
              L        +     E+ +L+ +L   + +   +   L+ +  +       + ++L+A
Sbjct: 1041 VRL------KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQA 1094

Query: 584  ANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ 643
            A  +   E+A  K+   +   E  G + + +  LDS  +   K+ E  K  L     A +
Sbjct: 1095 ALARLDDEIA-QKNNALKKIRELEGHISDLQEDLDSERAARNKA-EKQKRDLGEELEALK 1152

Query: 644  KEIGEL---KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELA-GL 699
             E+ +     A  + ++ + + E+  L+   D ET  H  + + +R+K  +A EEL   L
Sbjct: 1153 TELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQL 1212

Query: 700  QRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA 759
            ++  RA+  +  ++  LE + A       ELRV    K +VE++ +      L+ Q+   
Sbjct: 1213 EQFKRAKANLDKNKQTLEKENAD---LAGELRVLGQAKQEVEHKKKK-----LEAQVQEL 1264

Query: 760  EKKMLDYERLQRAEAQGK-----QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDI 814
            + K  D ER  RAE   K      EVES+   L  AE +   +    +S  + + ++ ++
Sbjct: 1265 QSKCSDGER-ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL 1323

Query: 815  SEETIRTK-----------ETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSG 863
             +E  R K           E    LQD+L++  +    L      L  Q+S  + K +  
Sbjct: 1324 LQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDF 1383

Query: 864  EKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL------- 916
               V+AL + K+R + E+E ++++  + +     + +   R ++ L++L V L       
Sbjct: 1384 ASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLV 1443

Query: 917  --LEANRHS----PGPERDLS------REVHKAEWRIKEQKLKDDIRGLREKLTGLDKEK 964
              LE  +         E+++S      R+  +AE R KE K     R L E L   ++ +
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503

Query: 965  SLSDQRRYSLID-PSSAPELLRLQHQLMSTEDALRDALDQAQ-QVEKLMEAMRSCPD-KA 1021
              +   +  + D  SS  ++ +  H+L  ++ AL   +++ + Q+E+L + +++  D K 
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563

Query: 1022 QTIGNSGSANGIHQQDKAQKQE 1043
            +   N  +  G  ++D   + E
Sbjct: 1564 RLEVNMQALKGQFERDLQARDE 1585



 Score =  109 bits (272), Expect = 2e-23
 Identities = 147/676 (21%), Positives = 294/676 (43%), Gaps = 76/676 (11%)

Query: 367  HIEQLLAERDLERAEVAKATSHICE-VEKEIALLKAQHEQYVAEAEEKLQRARLLVESVR 425
            H+E+   ERDL+  +V  A   +C       A  K Q +    +  ++   A L + + +
Sbjct: 777  HLEE---ERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQ 833

Query: 426  --------KEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSL 477
                    K  + ++ Q EE + K ++LQ   E +   + +L+   Q +H+++ E E++L
Sbjct: 834  WWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQ-KHSQLTE-EKNL 891

Query: 478  LLEKAQAE-RLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDH 536
            L E+ QAE  L  E  + R+   A+K  + ++  E+  R  E E+  Q L          
Sbjct: 892  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL---------- 941

Query: 537  PDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAA-------NEKYA 589
               AE  ++ +++L   ++ + E    R K +      +A++ KL          N K +
Sbjct: 942  --QAERKKMAQQMLDLEEQLEEEEAA-RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998

Query: 590  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
            +E   L++++   T+ N+   +     L  L + H+  + +L+  L     ++Q E+ +L
Sbjct: 999  KERKLLEERISDLTT-NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKL 1056

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            K  +EG   +   ++ +LQA+         K++E L+  L    +E+A      +   E+
Sbjct: 1057 KRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIREL 1116

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            +   H  +LQE  D  R A        K + + R   + +E LK ++   E  +      
Sbjct: 1117 EG--HISDLQEDLDSERAAR------NKAEKQKRDLGEELEALKTEL---EDTLDSTATQ 1165

Query: 770  QRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIES-NDISEETIRTKETVEGL 828
            Q   A+ +QEV  L++ L       +A       +H   +E   +  E+  R K  ++  
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225

Query: 829  QDKLNKRDKEVTA-----------LTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRL 877
            +  L K + ++             +  + + L AQV  L+SKC  GE+    L  +  +L
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285

Query: 878  EAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKA 937
            + E+E+V+   ++A G+ + +++++      L + + LL E  R              K 
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR-------------QKL 1332

Query: 938  EWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDAL 997
                K ++L+++   L+++L   + E   + +R  S ++   +    +LQ    ST +AL
Sbjct: 1333 NVSTKLRQLEEERNSLQDQLDE-EMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEAL 1390

Query: 998  RDALDQAQ-QVEKLME 1012
             +   + Q ++E L +
Sbjct: 1391 EEGKKRFQKEIENLTQ 1406



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 159/720 (22%), Positives = 293/720 (40%), Gaps = 79/720 (10%)

Query: 335  SRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK 394
            S    + E   ++A+ +   T   E  K  + ++++     + E A++A     + + ++
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248

Query: 395  EIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESI 454
            E+   K + E  V E + K        E  R E  D  ++L+ E   V  +    E ++I
Sbjct: 1249 EVEHKKKKLEAQVQELQSKCSDG----ERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304

Query: 455  --TKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEEL 512
               K      +QL+  +  EL Q    +K      LR+L + R       S   QL+EE+
Sbjct: 1305 KLAKDVASLSSQLQDTQ--ELLQEETRQKLNVSTKLRQLEEER------NSLQDQLDEEM 1356

Query: 513  TLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALK 572
              ++     +    +          D A  +   E L    K  Q+E   L  +YE+   
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTV---EALEEGKKRFQKEIENLTQQYEEKAA 1413

Query: 573  AYQAEVDKLRAANEKYAQEVAGLK---DKVQQATSENMGLMDNWKSKLDSLASDHQKSLE 629
            AY    DKL     +  QE+  L    D  +Q  S     ++  + K D L ++ +K++ 
Sbjct: 1414 AY----DKLEKTKNRLQQELDDLVVDLDNQRQLVSN----LEKKQRKFDQLLAE-EKNIS 1464

Query: 630  DLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETA--MHVKEKEALRE 687
               A       A+ +E  E KA+     +E  LE     AK +LE    M   E E L  
Sbjct: 1465 SKYADERDRAEAEARE-KETKALSLARALEEALE-----AKEELERTNKMLKAEMEDLVS 1518

Query: 688  KLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRR---DAELRVH-ELEKLDVEYR 743
               +  + +  L++  RA LE Q  + + +L+E +D+ +   DA+LR+   ++ L  ++ 
Sbjct: 1519 SKDDVGKNVHELEKSKRA-LETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1577

Query: 744  GQAQAIEF--------LKEQISLAEKKMLDYERLQRA-EAQGKQEVES-LREKLLVAENR 793
               QA +         L+ Q+   E ++ D ER QRA  A  K+++E  L++  L A++ 
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELED-ERKQRALAAAAKKKLEGDLKDLELQADSA 1636

Query: 794  LQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQV 853
            ++  E           +  D   E    + + + +     + +K+  +L +    L+  +
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696

Query: 854  SALESKCKSGEKKVD--------------ALLKEKRRLEAELETVSRKTHDASGQLVLIS 899
            +A E   K  + + +              AL  EKRRLEA +  +  +  +  G +  +S
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756

Query: 900  QELLR----KERSLNELRVLLLEANRHSPGPE------RDLSREVHKAEWRIKEQKLKDD 949
              + +     E+  NEL      A ++    +      ++L  ++H+ E  +K  K K  
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVK-SKFKST 1815

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEK 1009
            I  L  K+  L+ E+   + R       S   +  +L+  L+  ED  + A    +Q EK
Sbjct: 1816 IAALEAKIAQLE-EQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 148/606 (24%), Positives = 253/606 (41%), Gaps = 90/606 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L+++  +     S   AL+E  K  Q+ IE L  + + + A   K       +EK    L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK-------LEKTKNRL 1425

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERR---KVEDLQFRVEEESITK 456
            + + +  V +    L   R LV ++ K++      L EE+    K  D + R E E+  K
Sbjct: 1426 QQELDDLVVD----LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 457  GD--LETQTQLEHARIG--ELEQSLLLEKAQAERLLRELAD-NRLTTVAEKSRVLQLEEE 511
                L     LE A     ELE++  + KA+ E L+    D  +     EKS+   LE +
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK-RALETQ 1540

Query: 512  LTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLR------------ERLLSASKEHQRE 559
            +   + ++EEL+           D   A E  +LR            ER L A  E   E
Sbjct: 1541 MEEMKTQLEELE-----------DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589

Query: 560  SGVLRDKYEKALKAYQAEVD---KLRAANEKYAQEVAG-LKDKVQQATSENMGLMDNWKS 615
                R + ++ L  Y+ E++   K RA      +++ G LKD   QA S   G  +  K 
Sbjct: 1590 K---RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1646

Query: 616  --KLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDL 673
              KL +   D Q+ LED +A+        + EI       E  K    LE   +Q + DL
Sbjct: 1647 LRKLQAQMKDFQRELEDARAS--------RDEI--FATAKENEKKAKSLEADLMQLQEDL 1696

Query: 674  ETAMHVK-----EKEALREKLQEAQEELAGLQRHWR------AQLEVQASQHRLELQEAQ 722
              A   +     EKE L E+L  +      LQ   R      AQLE +  + +  ++   
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756

Query: 723  DQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLD--YERLQRAEAQGKQEV 780
            D+ R A  +  +L       R  AQ  E  ++Q+    K++    +E     +++ K  +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTI 1816

Query: 781  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQD--KLNKRDKE 838
             +L  K+   E +++  EA      T  ++  D      + KE +  ++D  K+ ++ KE
Sbjct: 1817 AALEAKIAQLEEQVEQ-EAREKQAATKSLKQKDK-----KLKEILLQVEDERKMAEQYKE 1870

Query: 839  VTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLI 898
                  Q E   A+V  L+ + +  E++   +   +R+L+ EL+  + ++++A G+ V  
Sbjct: 1871 ------QAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT-ESNEAMGREVNA 1923

Query: 899  SQELLR 904
             +  LR
Sbjct: 1924 LKSKLR 1929



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 69/318 (21%), Positives = 141/318 (44%), Gaps = 28/318 (8%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQR 416
            L+  LK+ +   +  +  R+    ++ K  + + + ++E+   +A  ++  A A+E  ++
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK 1681

Query: 417  ARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESIT-----KGDLETQTQLEHARIG 471
            A+ L   + + + DL+    E  RK  DL+     E +      +  L+ + +   ARI 
Sbjct: 1682 AKSLEADLMQLQEDLA--AAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIA 1739

Query: 472  ELEQSLLLEKA--------------QAERLLRELADNRLTTVAEKSRVLQLEEELTLRRG 517
            +LE+ L  E+               QAE+L  ELA  R T    +S   QLE +    R 
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRS 1799

Query: 518  EIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAE 577
            ++ E++   + S          A+I +L E++   ++E Q  +  L+ K +K LK    +
Sbjct: 1800 KLHEMEGA-VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK-DKKLKEILLQ 1857

Query: 578  VDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNS 637
            V+  R   E+Y ++      +V+Q   +    ++  + +   + ++ +K   +L     S
Sbjct: 1858 VEDERKMAEQYKEQAEKGNARVKQLKRQ----LEEAEEESQRINANRRKLQRELDEATES 1913

Query: 638  GPGAQQKEIGELKAVMEG 655
               A  +E+  LK+ + G
Sbjct: 1914 NE-AMGREVNALKSKLRG 1930



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 66/292 (22%), Positives = 122/292 (41%), Gaps = 51/292 (17%)

Query: 333  RPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEV 392
            R SR  +   T+    +K     A    L+E     E+   + DLE+ E+A+  +     
Sbjct: 1665 RASRDEIFA-TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRAR----LLVESVRK---EKVDLSNQLEEER------ 439
               +   K + E  +A+ EE+L+  +     + + VRK   +   LSN+L  ER      
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783

Query: 440  --------RKVEDLQFRVEE-ESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRE 490
                    R+ ++L+ ++ E E   K   ++      A+I +LE+ +  E  + +   + 
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843

Query: 491  L--ADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRER 548
            L   D +L     K  +LQ+E+E  +     E+ ++               A + +L+ +
Sbjct: 1844 LKQKDKKL-----KEILLQVEDERKMAEQYKEQAEK-------------GNARVKQLKRQ 1885

Query: 549  LLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ 600
            L  A +E QR +   R          Q E+D+   +NE   +EV  LK K++
Sbjct: 1886 LEEAEEESQRINANRR--------KLQRELDEATESNEAMGREVNALKSKLR 1929



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 50/228 (21%), Positives = 99/228 (43%), Gaps = 27/228 (11%)

Query: 326  VASSVGGRPSRSGLLTETSSRYAR-------KISGTTALQEALKEKQQHIEQLLAERDLE 378
            +ASS+ GR +         +R A+       +     A+ + +++  Q  EQL  E   E
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776

Query: 379  RAEVAKATSHICEVEKEIALL-----------KAQHEQYVAEAEEKLQRARLLVESVRKE 427
            R+   K  S   ++E++   L           K++ +  +A  E K+ +    VE   +E
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEARE 1836

Query: 428  KVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERL 487
            K   +  L+++ +K++++  +VE+E       + Q +  +AR+ +L++ L     +AE  
Sbjct: 1837 KQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL----EEAEEE 1892

Query: 488  LRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPD 535
             + +  NR     E     +  E +     E+  L+  L   GPPP +
Sbjct: 1893 SQRINANRRKLQRELDEATESNEAM---GREVNALKSKL--RGPPPQE 1935


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  117 bits (294), Expect = 4e-26
 Identities = 165/749 (22%), Positives = 323/749 (43%), Gaps = 97/749 (12%)

Query: 355  TALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKL 414
            T ++  L+E ++  +QLL E+++   ++   T    E E+  A L A+ +    E EE L
Sbjct: 869  TKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ----ELEEIL 924

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELE 474
                  VE   +    L N+ ++ +  ++DL+ +++EE   +  L+ +     A+I ++E
Sbjct: 925  HDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKME 984

Query: 475  QSLLLEKAQAERLLRE--LADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPP 532
            + +LL + Q  + ++E  L ++R   +AE S  L  EEE      +I   Q+ ++     
Sbjct: 985  EEILLLEDQNSKFIKEKKLMEDR---IAECSSQLAEEEEKAKNLAKIRNKQEVMI----- 1036

Query: 533  PPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEV 592
                 D  E L+  E+     ++ +R+        +  +   QA++D+L+    K  +E+
Sbjct: 1037 ----SDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL 1092

Query: 593  AGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAV 652
             G   +    T      +   + +L +  ++ Q+  E  KA+ N      +K+  +L   
Sbjct: 1093 QGALARGDDETLHKNNALKVVR-ELQAQIAELQEDFESEKASRNKA----EKQKRDLSEE 1147

Query: 653  MEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQAS 712
            +E +K E +  L    A+ +L T    K ++ + E  +  +EE     ++  AQ++    
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRT----KREQEVAELKKALEEE----TKNHEAQIQDMRQ 1199

Query: 713  QHRLELQEAQDQRRDAELRVHELEK----LDVEYRGQAQAIEFLKEQISLAE--KKMLD- 765
            +H   L+E  +Q   A+     LEK    L+ + +  A  ++ L++  + +E  +K LD 
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259

Query: 766  -YERLQRAEAQGKQEVESLREKLLVAENRLQAVEAL--------------CSSQHTHMIE 810
              + L    ++G +    L EK    +N L  V  L               +S  + + +
Sbjct: 1260 QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD 1319

Query: 811  SNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTE-------MLRAQVSALESKCKSG 863
            + ++ +E  R K     L  ++ + ++E  +L  Q E        L  QV AL+S+    
Sbjct: 1320 TQELLQEETRQK---LNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376

Query: 864  EKKVD-------ALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL 916
            +KKVD       +L + K++L  + E +S++  + +     + +   R ++ L++L V L
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436

Query: 917  -------------------LEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKL 957
                               L A   S        R+  +AE R KE K     R L E L
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496

Query: 958  TGLDKEKSLSDQRRYSLID-PSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRS 1016
               ++ +  + Q R  + D  SS  ++ +  H+L  ++ AL       QQVE++   +  
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE------QQVEEMRTQLEE 1550

Query: 1017 CPDKAQTIGNSGSANGIHQQD-KAQKQED 1044
              D+ Q   ++     ++ Q  KAQ + D
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKAQFERD 1579



 Score =  109 bits (273), Expect = 1e-23
 Identities = 158/696 (22%), Positives = 302/696 (43%), Gaps = 93/696 (13%)

Query: 397  ALLKAQHEQY------------VAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVED 444
            A LK +H Q+            V   EE+LQ     +  V++++  +  +LEE  RK + 
Sbjct: 825  AYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQ 884

Query: 445  LQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSR 504
            L   +EE++I    L+ +T+L  A   E+   L  +K + E +L +L ++R+    E+++
Sbjct: 885  L---LEEKNILAEQLQAETEL-FAEAEEMRARLAAKKQELEEILHDL-ESRVEEEEERNQ 939

Query: 505  VLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSAS-KEHQRESGVL 563
            +LQ E++    +  I++L++ L        +   A + L+L +    A  K+ + E  +L
Sbjct: 940  ILQNEKK--KMQAHIQDLEEQL-------DEEEGARQKLQLEKVTAEAKIKKMEEEILLL 990

Query: 564  RDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASD 623
             D+  K +K  +   D++   + + A+E    K+  +    + + ++ + + +L      
Sbjct: 991  EDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEV-MISDLEERLKKEEKT 1049

Query: 624  HQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKME---HQLELGNLQAKHDLETAMH-- 678
             Q+ LE  K  L+      Q +I EL+A ++ +K++    + EL    A+ D ET +H  
Sbjct: 1050 RQE-LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDET-LHKN 1107

Query: 679  -----VKEKEALREKLQE------------------AQEELAGLQRHWRAQLEVQASQHR 715
                 V+E +A   +LQE                    EEL  L+      L+  A+Q  
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167

Query: 716  LELQEAQD-----QRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ 770
            L  +  Q+     +  + E + HE +  D+  R  A A+E L EQ+  A++   + E+  
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQR-HATALEELSEQLEQAKRFKANLEK-- 1224

Query: 771  RAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQD 830
                  KQ +E+  ++L      LQ V+A   S+H              +    V+ L  
Sbjct: 1225 -----NKQGLETDNKELACEVKVLQQVKA--ESEHKRK-----------KLDAQVQELHA 1266

Query: 831  KLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD 890
            K+++ D+    L  +   L+ ++  + +  +  EKK     K+   LE++L+       +
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE 1326

Query: 891  ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLK-DD 949
             + Q + +S  + + E   N L+    E         ++L ++V   + ++ + K K DD
Sbjct: 1327 ETRQKLNLSSRIRQLEEEKNSLQ----EQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDPSSA---PELLRLQHQLMSTEDALRDALDQAQQ 1006
              G  E L    K+K L D    S      A    +L + +++L    D L   LD  +Q
Sbjct: 1383 DLGTIESLEEA-KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQ 1441

Query: 1007 VEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQ 1042
            V   +E  +   D+      S SA    ++D+A+ +
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAE 1477



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 163/757 (21%), Positives = 315/757 (41%), Gaps = 132/757 (17%)

Query: 354  TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEK 413
            TTA Q+ L+ K+   EQ +AE  L++A   +  +H    E +I  ++ +H   + E  E+
Sbjct: 1161 TTAAQQELRTKR---EQEVAE--LKKALEEETKNH----EAQIQDMRQRHATALEELSEQ 1211

Query: 414  LQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGEL 473
            L++A+    ++ K K  L    +E   +V+ LQ    E    +  L+ Q Q  HA++ E 
Sbjct: 1212 LEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEG 1271

Query: 474  EQSLLLEKAQAERLLRELADNRLTTVAE-KSRVLQLEEELTLRRGEIEELQQCLLHSGPP 532
            ++ L +E A+    L+   DN  T + E + + ++  ++      ++++ Q+ L      
Sbjct: 1272 DR-LRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE--- 1327

Query: 533  PPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAE--------------V 578
                 + +  +R  E   ++ +E Q E    R   EK + A Q++              +
Sbjct: 1328 TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTI 1387

Query: 579  DKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLN-- 636
            + L  A +K  ++   L  ++++              KL+   +  Q+ L+DL   L+  
Sbjct: 1388 ESLEEAKKKLLKDAEALSQRLEEKALAY--------DKLEKTKNRLQQELDDLTVDLDHQ 1439

Query: 637  ----SGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAK------------HDLETAMHVK 680
                S    +QK+  +L A  + I   +  E    +A+              LE A+  K
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAK 1499

Query: 681  EK-EALREKLQEAQEELAG-----------LQRHWRAQLEVQASQHRLELQEAQDQRRDA 728
            E+ E   ++L+   E+L             L++  RA LE Q  + R +L+E +D     
Sbjct: 1500 EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA-LEQQVEEMRTQLEELED----- 1553

Query: 729  ELRVHELEKLDVEYRGQAQAIEFLKEQISL----AEKKMLDYERLQRAEAQGKQEVESLR 784
            EL+  E  KL +E   QA   +F ++  +      EKK L  ++++  EA    E+E  R
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA----ELEDER 1609

Query: 785  EKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT--------KETVEGLQDKLNKRD 836
            ++  +A    + +E         +  +N   +E I+         K+    L++    RD
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRD 1669

Query: 837  ----------KEVTALTSQTEMLRAQVSALESKCKSGEKKVD--------------ALLK 872
                      K++ +L ++   L+ ++++ E   +  E++ D              ALL 
Sbjct: 1670 EIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729

Query: 873  EKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLL---EANRHSPGPERD 929
            EKRRLEA +  +  +  +    + L++    +    ++ L   L     A + S    + 
Sbjct: 1730 EKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQ 1789

Query: 930  LSREVHKAEWRIKE------QKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPEL 983
            L R+  + + +++E       K K  I  L  K+  L+++     + R      ++A +L
Sbjct: 1790 LERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKER------AAANKL 1843

Query: 984  LR-----LQHQLMSTEDALRDALDQAQQVEKLMEAMR 1015
            +R     L+   M  ED  R A    +Q+EK    M+
Sbjct: 1844 VRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMK 1880



 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 110/573 (19%), Positives = 226/573 (39%), Gaps = 59/573 (10%)

Query: 344  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
            S R   K      L++     QQ ++ L  + D +R    +  S++ + +K+   L A+ 
Sbjct: 1405 SQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR----QVASNLEKKQKKFDQLLAEE 1460

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQT 463
            +   A   E+  RA         + + L+  LEE     E+ + + ++      DL +  
Sbjct: 1461 KSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSK 1520

Query: 464  QLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQ 523
                  + ELE+S    + Q E +  +L +      A +   L+LE  +   + + E   
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580

Query: 524  QCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVL----RDKYEKALKAYQAEVD 579
            Q           + +   +L  + R L A  E +R+   L    + K E  LK  +A+++
Sbjct: 1581 Q------TRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIE 1634

Query: 580  KLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGP 639
                A ++  +++                       KL +   D+Q+ LE+ +A+ +   
Sbjct: 1635 AANKARDEVIKQL----------------------RKLQAQMKDYQRELEEARASRDE-I 1671

Query: 640  GAQQKEIGELKAVMEGIKMEHQLELGNLQ-AKHDLETAMHVKEKEALREKLQEAQEELAG 698
             AQ KE  +    +E   ++ Q EL + + A+   E     +E++ L +++  +    + 
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAE-----QERDELADEITNSASGKSA 1726

Query: 699  LQRHWR------AQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFL 752
            L    R      AQLE +  + +  ++   D+ R   L+V  L       R  AQ  +  
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA 1786

Query: 753  KEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESN 812
            ++Q+    K++    +LQ  E   K + ++    L   E ++  +E     +      +N
Sbjct: 1787 RQQLERQNKEL--KAKLQELEGAVKSKFKATISAL---EAKIGQLEEQLEQEAKERAAAN 1841

Query: 813  DISEET-IRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALL 871
             +   T  + KE    ++D+    D+       Q E   A++  L+ + +  E++     
Sbjct: 1842 KLVRRTEKKLKEIFMQVEDERRHADQ----YKEQMEKANARMKQLKRQLEEAEEEATRAN 1897

Query: 872  KEKRRLEAELETVSRKTHDASGQLVLISQELLR 904
              +R+L+ EL+  +      S ++  +   L R
Sbjct: 1898 ASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score =  117 bits (294), Expect = 4e-26
 Identities = 166/721 (23%), Positives = 287/721 (39%), Gaps = 101/721 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            LTE  +     ++  T  ++AL+E  Q   Q L +   E   V+  T     +E+++  L
Sbjct: 1027 LTEEMAALDESVARLTKEKKALQEAHQ---QALGDLQAEEDRVSALTKAKLRLEQQVEDL 1083

Query: 400  KAQHEQY------VAEAEEKLQR-ARLLVESVR---KEKVDLSNQLEEERRKVEDLQFRV 449
            +   EQ          A+ KL+   +L  ESV    ++K  L  +L+++  ++  L  RV
Sbjct: 1084 ECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRV 1143

Query: 450  EEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLE 509
            E+E +    ++ + +   AR  ELE+ L  E+A   R+ ++         AE +R     
Sbjct: 1144 EDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQR--------AEAAR----- 1190

Query: 510  EELTLRRGEIEELQQCLLHSGPPPPDHPDA-----AEILRLRERLLSASKEHQRESGVLR 564
                    E+EEL + L  +G       +      AE+ RLR  L  A+  H+     LR
Sbjct: 1191 --------ELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALR 1242

Query: 565  DKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDH 624
             K  +       +VD L+   +K  +E + L+ +V    + N+  +   K+  + L   +
Sbjct: 1243 RKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAA-NVETLTRAKASAEKLCRTY 1301

Query: 625  QKSLEDLK----------ATLNSGPGAQQKEIGELKAVMEGIK-MEHQLELGNLQAKHDL 673
            +  L + K          A  ++  G  Q E GEL  ++E  + +  QL  G   A   L
Sbjct: 1302 EDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSL 1361

Query: 674  ETAMHVKEKEA-------------------LREKLQEAQEELAGLQR----------HWR 704
            E      E+E+                   LRE+ +E  E  A LQR           WR
Sbjct: 1362 EELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWR 1421

Query: 705  AQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISL-AEKKM 763
            ++ E  A Q   EL+EA   ++   LR+ E E+       +  ++E  K ++   +E   
Sbjct: 1422 SKYEADAIQRTEELEEA---KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1478

Query: 764  LDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKE 823
            L+ ER   A A   ++   L   L   E R +  E +         ES  +  E  R + 
Sbjct: 1479 LELERATSAAAALDKKQRHLERAL---EERRRQEEEMQRELEAAQRESRGLGTELFRLRH 1535

Query: 824  TVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELET 883
              E   + L         L  + + L+ ++S L  +     K +  L K K+ LE E   
Sbjct: 1536 GHEEALEALE-------TLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSE 1588

Query: 884  VSRKTHDASGQLVLISQELLRKERSLNELRV----LLLEANRHSPGPERDLSREVHKAEW 939
            +     +A G L L   + LR +  L++++      L E +       R+  R V   + 
Sbjct: 1589 IQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQA 1648

Query: 940  RI-KEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALR 998
             +  E + +++   L++K+ G      L  Q  ++    + A    RL    +  E A R
Sbjct: 1649 SLDAETRARNEALRLKKKMEG--DLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGR 1706

Query: 999  D 999
            D
Sbjct: 1707 D 1707



 Score =  100 bits (248), Expect = 9e-21
 Identities = 161/728 (22%), Positives = 297/728 (40%), Gaps = 122/728 (16%)

Query: 391  EVEKEIALLKAQHEQY---VAEAEEKLQRARLLVESVRKEKVDLSNQLEEER-------- 439
            + E+E+A L+A+       +A AE K Q       S+ +EK DL+ QL+ E+        
Sbjct: 893  QAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEE 952

Query: 440  -------------RKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQ-----SLLLEK 481
                          KV++L  R+E+E     DL  + +       EL++      L L K
Sbjct: 953  RCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAK 1012

Query: 482  AQAERLLRELADNRLTTVAEKSRVL-QLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA 540
            A+ E   ++  +N++  + E+   L +    LT  +  ++E  Q  L       D   A 
Sbjct: 1013 AEKE---KQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSAL 1069

Query: 541  EILRLR-----------------------------ERLLSASKEHQRESGVLRDKYEKAL 571
               +LR                             E  L  ++E   ++   + + E+ L
Sbjct: 1070 TKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKL 1129

Query: 572  KAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNW------KSKLDSLASDHQ 625
            K   +E+ +L    E      A ++ K+++  +    L +        +++++   ++  
Sbjct: 1130 KKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAA 1189

Query: 626  KSLEDLKATLNSGPGA----------QQKEIGELKAVMEGIKMEHQLELGNL---QAKHD 672
            + LE+L   L    GA          ++ E+G L+  +E   + H+  +  L   QA+  
Sbjct: 1190 RELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGA 1249

Query: 673  LETAMHVKEKEALREKLQEAQEELA----GLQRHWRAQLEVQASQHRLELQEAQDQRRDA 728
             E    V   + +R+KL++ + EL      L  +       +AS  +L  +  +DQ  +A
Sbjct: 1250 AELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKL-CRTYEDQLSEA 1308

Query: 729  ELRVHELEKLDVEYRGQAQAIEFLKEQIS-LAEKKMLDYERLQRAEAQGKQEVESLREKL 787
            +++V EL++   +   Q   ++    ++S L E+K     +L R +A   Q +E LR +L
Sbjct: 1309 KIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQL 1368

Query: 788  LVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTS--- 844
               E   +A  AL  +      + + + E+     E    LQ  L+K + EV    S   
Sbjct: 1369 ---EEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYE 1425

Query: 845  -----QTEMLRAQVSALESKCKSGEKKVDA-------LLKEKRRLEAELETVSRKTHDAS 892
                 +TE L      L  + +  E+ V+A       L K K RL+ E E V+ +   A+
Sbjct: 1426 ADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERAT 1485

Query: 893  GQLVLISQELLRKERSLNELRVL-------LLEANRHSPGPERDLSREVHKAEWRIKE-Q 944
                 + ++    ER+L E R         L  A R S G   +L R  H  E  ++  +
Sbjct: 1486 SAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALE 1545

Query: 945  KLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQA 1004
             LK + + L+E+++ L  + SLS +         S  EL + +  L   +  ++ AL++A
Sbjct: 1546 TLKRENKNLQEEISDLTDQVSLSGK---------SIQELEKTKKALEGEKSEIQAALEEA 1596

Query: 1005 QQVEKLME 1012
            +   +L E
Sbjct: 1597 EGALELEE 1604



 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 163/683 (23%), Positives = 297/683 (43%), Gaps = 95/683 (13%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQL-----LAERDLERA-----EVAKATSHI 389
            L + S++  R  + +  L   L+EK+  I QL     LA + LE       E +KA S +
Sbjct: 1319 LADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSAL 1378

Query: 390  CEVEKEIA----LLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEER-RKVED 444
                + +     LL+ QHE+  AEA+ +LQR   L+     E     ++ E +  ++ E+
Sbjct: 1379 AHAVQALRHDCDLLREQHEEE-AEAQAELQR---LLSKANAEVAQWRSKYEADAIQRTEE 1434

Query: 445  LQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSR 504
            L+   ++ ++   + E   +  +A+   LE++ L  + ++E +  EL        A   +
Sbjct: 1435 LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKK 1494

Query: 505  VLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLR----------ERLLSASK 554
               LE  L  RR + EE+Q+ L              E+ RLR          E L   +K
Sbjct: 1495 QRHLERALEERRRQEEEMQREL--EAAQRESRGLGTELFRLRHGHEEALEALETLKRENK 1552

Query: 555  EHQRESGVLRDKY----------EKALKAYQAEVDKLRAANEKY--AQEVAGLKD-KVQQ 601
              Q E   L D+           EK  KA + E  +++AA E+   A E+   K  ++Q 
Sbjct: 1553 NLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQL 1612

Query: 602  ATSENMGLMDNWKSKLD----SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIK 657
              S+    +D   ++ D    +L  +HQ+++E L+A+L++   A+ + +  LK  MEG  
Sbjct: 1613 ELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEAL-RLKKKMEGDL 1671

Query: 658  MEHQLELGNLQAKH-DLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQ-LEVQASQHR 715
             + +L+LG+   +  + + A  + + +   E+    +E+    + H +AQ LE +AS   
Sbjct: 1672 NDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLA 1731

Query: 716  LELQE--AQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQIS--LAEKKMLDYERLQR 771
             EL+E  A  ++ +   R+ E E L+   R     +  L  Q +  L +KK L+ +    
Sbjct: 1732 AELEELRAALEQGERSRRLAEQELLEATER-----LNLLHSQNTGLLNQKKKLEADL--- 1783

Query: 772  AEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDK 831
              AQ   EVE   ++   AE + +      +     + +  D S    R K+T+E    +
Sbjct: 1784 --AQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRE 1841

Query: 832  LNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDA 891
            L  R +E                A ++  + G+K+V  L  + R LEAEL+   +K  +A
Sbjct: 1842 LQARLEE----------------AEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEA 1885

Query: 892  SGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREV------HKAEWRIKEQK 945
                    + + + ER + EL     E +R +    +DL  ++      +K ++   EQ+
Sbjct: 1886 -------LKGVRKHERRVKEL-AYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQ 1937

Query: 946  LKDDIRGLREKLTGLDKEKSLSD 968
               ++   R+    LD  +  +D
Sbjct: 1938 ANTNLAKYRKAQHELDDAEERAD 1960



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 71/307 (23%), Positives = 140/307 (45%), Gaps = 23/307 (7%)

Query: 673  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLE---VQASQHR----LELQEAQDQR 725
            L +A   +E  ALR +L+  +  LA  +   R +LE   V  +Q +    L+LQ  QD  
Sbjct: 889  LRSAQAEEELAALRAELRGLRGALAAAEAK-RQELEETHVSITQEKNDLALQLQAEQDNL 947

Query: 726  RDAELRVHELEKLDVEYRGQAQAI-EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLR 784
             DAE R H L K  V+  G+ + + E L+++  +         +L+    + K++++ L+
Sbjct: 948  ADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLK 1007

Query: 785  EKLLVAENRLQAVEALCSSQHTHMIESND----ISEETIRTKETVEGLQDKLNKRDKEVT 840
              L  AE   QA E    +    M   ++    +++E    +E  +     L   +  V+
Sbjct: 1008 LTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVS 1067

Query: 841  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 900
            ALT     L  QV  LE   +  +K      + KR+LE +L+       DA+     + +
Sbjct: 1068 ALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEE 1127

Query: 901  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHK--AEWRIKEQKLKDDIRGLREKLT 958
            +L +K+  L++L + + +        E+ L  ++ K   E + + ++L++++   R    
Sbjct: 1128 KLKKKDSELSQLSLRVED--------EQLLGAQMQKKIKELQARAEELEEELEAERAARA 1179

Query: 959  GLDKEKS 965
             ++K+++
Sbjct: 1180 RVEKQRA 1186



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 44/181 (24%), Positives = 83/181 (45%), Gaps = 8/181 (4%)

Query: 836  DKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQL 895
            ++E+ AL ++   LR  ++A E+K +  E+   ++ +EK  L  +L+       DA  + 
Sbjct: 895  EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERC 954

Query: 896  VLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLRE 955
             L+ +  ++ E  + EL   L +          DL+    K E    E  LK DI  L+ 
Sbjct: 955  HLLIKSKVQLEGKVKELSERLEDEEE----VNADLAARRRKLEDECTE--LKKDIDDLKL 1008

Query: 956  KLTGLDKEKSLSDQRRYSLIDPSSA--PELLRLQHQLMSTEDALRDALDQAQQVEKLMEA 1013
             L   +KEK  ++ +  +L +  +A    + RL  +  + ++A + AL   Q  E  + A
Sbjct: 1009 TLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEEDRVSA 1068

Query: 1014 M 1014
            +
Sbjct: 1069 L 1069


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  117 bits (293), Expect = 6e-26
 Identities = 168/754 (22%), Positives = 332/754 (44%), Gaps = 76/754 (10%)

Query: 337  SGLLTETSSRYARKISGTTALQEALKEKQQ-HIEQLLAERDLERAEVAKATSHICEVEKE 395
            S L+T+  S     IS  +  +E L++  Q H  +L A+     +E+    + I + ++E
Sbjct: 465  SSLITDLQS----SISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQE 520

Query: 396  IALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESIT 455
            +A LK Q ++  A+  + LQ+     + +R +   LS+ L+++ ++++++    E++  T
Sbjct: 521  LAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV---AEKQEAT 577

Query: 456  KGD----LETQTQLEHARIGE----LEQSLLLEKAQAERLLRELADNRLTTVAE-----K 502
            + D    L T  +   A + E    L+Q   LEK +A +L  E+   +L    E     +
Sbjct: 578  RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKL--EILQQQLQVANEARDSAQ 635

Query: 503  SRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGV 562
            + V Q + E      ++EELQ C+         H   A++  L  +L S  ++   +  V
Sbjct: 636  TSVTQAQREKAELSRKVEELQACV--ETARQEQHEAQAQVAELELQLRSEQQKATEKERV 693

Query: 563  LRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLAS 622
             ++K ++  +  QA  + L+       +E    K +   A  E    +   K++  SL  
Sbjct: 694  AQEK-DQLQEQLQALKESLKVTKGSLEEE----KRRAADALEEQQRCISELKAETRSLVE 748

Query: 623  DH---QKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHV 679
             H   +K LE+ +A    G  A+ +++GE       +      E    Q   + E    V
Sbjct: 749  QHKRERKELEEERAG-RKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLV 807

Query: 680  KEKEALREKLQEAQEELAGLQRHWRAQ---LEVQASQHRLELQEAQDQ----RRDAELRV 732
            KE  A RE+ +++Q+E A     ++ Q   L+ +  + R ELQEA+++       +EL++
Sbjct: 808  KEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQI 867

Query: 733  -HELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLR------- 784
              +  +L   +   A+A++ ++E+   A+K   D   LQ   A   +EV  L        
Sbjct: 868  SRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAG 927

Query: 785  EKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTS 844
            E+   A   L    A    +    +E      +   T+  ++ ++ +  +   E+  L  
Sbjct: 928  EQQETASRELVKEPARAGDRQPEWLEEQQ-GRQFCSTQAALQAMEREAEQMGNELERL-- 984

Query: 845  QTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLR 904
            +  ++ +Q    E + +  E++V  L +E+ R +A+L         A  +L +  Q  L 
Sbjct: 985  RAALMESQGQQQEERGQQ-EREVARLTQERGRAQADLALEKA----ARAELEMRLQNALN 1039

Query: 905  KER-SLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE-QKLKDDIRGLREKLTGLDK 962
            ++R     L+  L  A     G +++L++       +IKE ++L+  ++ L+E+L   +K
Sbjct: 1040 EQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEK 1099

Query: 963  EKSLSD--QRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRS---- 1016
            E +     Q   +     + P+L  L+ ++   E   +   +QA  +E+ +EA R+    
Sbjct: 1100 EHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAE 1159

Query: 1017 -----------CPDKAQTIGNSGSANGIHQQDKA 1039
                         +KAQ +G+S SA    Q++ A
Sbjct: 1160 RDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193



 Score =  108 bits (270), Expect = 3e-23
 Identities = 186/788 (23%), Positives = 315/788 (39%), Gaps = 157/788 (19%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLA---ERDLERAEVAKATSHICEVEKEI 396
            L+ +  +  +++      QEA +  Q H +QL     ER+    E   A   +  +EKE 
Sbjct: 556  LSSSLKQKEQQLKEVAEKQEATR--QDHAQQLATAAEEREASLRERDAALKQLEALEKEK 613

Query: 397  ALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITK 456
            A      +Q +  A E    A+  V   ++EK +LS ++EE +  VE  +    E     
Sbjct: 614  AAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQV 673

Query: 457  GDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRR 516
             +LE Q + E  +  E E+ +  EK Q +  L+ L ++   T         LEEE     
Sbjct: 674  AELELQLRSEQQKATEKER-VAQEKDQLQEQLQALKESLKVTKG------SLEEEKRRAA 726

Query: 517  GEIEELQQCL------------LHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLR 564
              +EE Q+C+             H         + A    L  RL    + HQ E+ VLR
Sbjct: 727  DALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLR 786

Query: 565  DKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDH 624
             +  +A+ A      +     E+  +EVA  +++ + +  E       ++ +L +L  + 
Sbjct: 787  RELAEAMAAQHTAESEC----EQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEEC 842

Query: 625  QKSLEDLKATLNSGPG----------AQQKEIGELKA-VMEGIKMEHQLELGNLQAKHDL 673
            +K+ ++L+       G           QQ E+ EL A +   ++   + E+   +   DL
Sbjct: 843  EKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDL 902

Query: 674  E--------TAMHVKEKEALREKLQEAQE-----------ELAGLQRHWRAQLEVQASQH 714
                     T+  V   E L  K  E QE                Q  W   LE Q  + 
Sbjct: 903  STLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW---LEEQQGRQ 959

Query: 715  RLELQEA-QDQRRDAELRVHELEKLD------------------------VEYRGQAQAI 749
                Q A Q   R+AE   +ELE+L                          + RG+AQA 
Sbjct: 960  FCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQA- 1018

Query: 750  EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVA----ENRLQAVEALCSSQH 805
            +   E+ + AE +M    RLQ A  + + E  +L+E L  A    E + Q +  L   + 
Sbjct: 1019 DLALEKAARAELEM----RLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEA 1074

Query: 806  THMIESNDISEETIRTKETVEGLQDKLNKRDK----------EVTALTSQT----EMLRA 851
              + E  ++       ++TV+ L+++L K++K          E    T  T    E LRA
Sbjct: 1075 AQIKELEEL-------RQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRA 1127

Query: 852  QVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDAS-----GQLVLISQELLRKE 906
            +VS LE +C+  +++ D+L   +R LEA  E  SR   D++     GQL   +QEL   +
Sbjct: 1128 EVSKLEQQCQKQQEQADSL---ERSLEA--ERASRAERDSALETLQGQLEEKAQELGHSQ 1182

Query: 907  RSL----NELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDK 962
             +L     EL     +   HS   +          EW+ +  + + +       ++ L++
Sbjct: 1183 SALASAQRELAAFRTKVQDHSKAED----------EWKAQVARGRQEAERKNSLISSLEE 1232

Query: 963  EKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQ 1022
            E S+ +  R  L     + EL RL              + ++++ +KL E +R    +A+
Sbjct: 1233 EVSILN--RQVLEKEGESKELKRL-------------VMAESEKSQKLEERLRLL--QAE 1275

Query: 1023 TIGNSGSA 1030
            T  NS  A
Sbjct: 1276 TASNSARA 1283



 Score =  101 bits (251), Expect = 4e-21
 Identities = 177/811 (21%), Positives = 336/811 (41%), Gaps = 170/811 (20%)

Query: 379  RAEVAKATSHICEVEKEIA---LLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL 435
            + ++A   S+  E+E E+A    L  + +  +A  ++++ R  LL E      ++   +L
Sbjct: 220  KKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLE-PKEL 278

Query: 436  EEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQ---SLLLEKAQAERLLRELA 492
            EE R K E L  R+ E      DL+T+      +I +L +    L  +  +    L++L 
Sbjct: 279  EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ 338

Query: 493  D--NRLTTVAEKS------RVLQLEEELT--------------LRRGEIEELQQCL--LH 528
            D  N LT    K+      +  QLE+EL+              + +G++ +L++ L  L 
Sbjct: 339  DALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQ 398

Query: 529  SGPPPPDHPDAAEILRL------------------------------RERLLSASKEH-- 556
              PP        ++L+L                              +E  L A + H  
Sbjct: 399  DNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE 458

Query: 557  ---QRESGVLRD----------KYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQAT 603
               Q+ S ++ D            E+  +A QA   +L A       E+  L   +QQ  
Sbjct: 459  EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518

Query: 604  SENMGLMDNWKSKLDSLASDHQ------KSLEDLKATLNSGPGAQQKEIGELKAVMEGIK 657
             E  GL    K K   LA   Q      + L      L+S    +++++ E+    E  +
Sbjct: 519  QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578

Query: 658  MEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV-QASQHRL 716
             +H  +L     + +      ++E++A  ++L+  ++E A      + QL+V   ++   
Sbjct: 579  QDHAQQLATAAEEREAS----LRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSA 634

Query: 717  ELQEAQDQRRDAEL--RVHELEKL-----DVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            +    Q QR  AEL  +V EL+         ++  QAQ  E L+ Q+   ++K  + ER+
Sbjct: 635  QTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE-LELQLRSEQQKATEKERV 693

Query: 770  QRAEAQGKQEVESLREKLLVA-----ENRLQAVEAL-----CSSQ---------HTHMIE 810
             + + Q ++++++L+E L V      E + +A +AL     C S+           H  E
Sbjct: 694  AQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE 753

Query: 811  SNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDAL 870
              ++ EE    K    GL+ +L +  +   A  ++TE+LR +++   +   + E + + L
Sbjct: 754  RKELEEERAGRK----GLEARLQQLGE---AHQAETEVLRRELAEAMAAQHTAESECEQL 806

Query: 871  LKE----KRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGP 926
            +KE    + R E   +  ++       QL+ + +E  +  + L E +  +     HS   
Sbjct: 807  VKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS--- 863

Query: 927  ERDLSREVHK---------------AEWRIKEQKLKDDIRGLREKLTGLDKE-------- 963
            E  +SR+ ++                E  ++ QKL DD+  L+EK+    KE        
Sbjct: 864  ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV 923

Query: 964  KSLSDQR----RYSLIDPSSA----PELLRLQ--HQLMSTEDALRDALDQAQQVEKLMEA 1013
            +   +Q+    R  + +P+ A    PE L  Q   Q  ST+ AL+    +A+Q+   +E 
Sbjct: 924  RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELER 983

Query: 1014 MRSCPDKAQTIGNSGSANGIHQQDKAQKQED 1044
            +R+   ++Q         G  Q+++ Q++ +
Sbjct: 984  LRAALMESQ---------GQQQEERGQQERE 1005



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 171/830 (20%), Positives = 322/830 (38%), Gaps = 110/830 (13%)

Query: 297  KAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGT-T 355
            KA++  + A    A   S S   IS   +  + +    +R+    +     A+K++   +
Sbjct: 844  KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903

Query: 356  ALQEALKEKQQHIEQL--LAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE-E 412
             LQE +    + + +L  L  +  E+ E A       E+ KE A    +  +++ E +  
Sbjct: 904  TLQEKMAATSKEVARLETLVRKAGEQQETASR-----ELVKEPARAGDRQPEWLEEQQGR 958

Query: 413  KLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGE 472
            +    +  ++++ +E   + N+LE  R  + + Q + +EE   +G  E +        G 
Sbjct: 959  QFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE---RGQQEREVARLTQERGR 1015

Query: 473  LEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQ--LEEELTLRRGEIEELQQCLLHSG 530
             +  L LEKA    L   L  N L     +   LQ  L   LT + G+ +EL +      
Sbjct: 1016 AQADLALEKAARAELEMRL-QNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEA 1074

Query: 531  PPPPDHPDAAEILR-LRERLLSASKEHQRESGVLRDKYEKA------LKAYQAEVDKLRA 583
                +  +  + ++ L+E+L    KEH   SG   +   +       L+A +AEV KL  
Sbjct: 1075 AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQ 1134

Query: 584  ANEKYAQEVAGLKDKVQQ---ATSENMGLMDNWKSKLDSLAS------------------ 622
              +K  ++   L+  ++    + +E    ++  + +L+  A                   
Sbjct: 1135 QCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAA 1194

Query: 623  ------DHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETA 676
                  DH K+ ++ KA +  G    +++   + ++ E + + ++  L       +L+  
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL 1254

Query: 677  MHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELE 736
            +  +      EK Q+ +E L  LQ    +     A +     +E Q  R +AE +    E
Sbjct: 1255 VMAES-----EKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASE 1309

Query: 737  KLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAEN---R 793
             L  E   QA+  E L +++   ++K    E+            ++L  +LL A++   +
Sbjct: 1310 NLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ 1369

Query: 794  LQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTAL----------T 843
            LQA +A    +H          EE  ++K+   GL+ +L +  +E+  L           
Sbjct: 1370 LQAEQAAAEKRH---------REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE 1420

Query: 844  SQTEMLRAQVSALESKCKSGEKKVDALLKEKRR------------LEAELETVSRK---- 887
               + LRA+ ++   +  S  KK   LL E+ R            LE EL+    K    
Sbjct: 1421 RTAQQLRAEKASYAEQL-SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQE 1479

Query: 888  ----THDASGQLVLISQELLRKERSLNEL-------RVLLLEANRHSPGPERDLSREVHK 936
                  DA  +L  + +E     R L  +       +V +LE  +      + L+ +V +
Sbjct: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539

Query: 937  AEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSL--IDPSSAPELLRLQHQLMSTE 994
             E   +EQ     +  L +KL   D+   +  Q+  ++      S  E  RLQ QL   +
Sbjct: 1540 LEVFQREQ--TKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597

Query: 995  DALRDALDQAQQVEKLMEAMRSCPD--KAQTIGNSGSANGIHQQDKAQKQ 1042
              L      A+  +  ME  ++  D  K Q          + Q  K  K+
Sbjct: 1598 AQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE 1647



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 142/654 (21%), Positives = 253/654 (38%), Gaps = 104/654 (15%)

Query: 298  AKKTKRMAMGVSALTHS-----PSSSSISSVSSVASSVGGRPSRS---------GLLTET 343
            AKK K  A G  A + +     P+   + ++ +  S +  +  +           L  E 
Sbjct: 1095 AKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAER 1154

Query: 344  SSRYARKISGTTALQEALKEKQQ---HIEQLLAERDLERAEVAKATSHICEVEKEIALLK 400
            +SR A + S    LQ  L+EK Q   H +  LA    E A          + E E    K
Sbjct: 1155 ASR-AERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE---WK 1210

Query: 401  AQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLE 460
            AQ    VA   ++ +R   L+ S+ +E   L+ Q+ E+  + ++L+  V  ES     LE
Sbjct: 1211 AQ----VARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLE 1266

Query: 461  TQTQL-------EHARIGELEQSL------LLEKAQAERLLRELADNRLTTVAEKSRVLQ 507
             + +L         AR  E   +L      L E+A+ +R+  E     LT+ AE++  L 
Sbjct: 1267 ERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELG 1326

Query: 508  LE----------EELTLRRGEIEELQQCLLHSGPPPPDH-------PDAAEILRLRERLL 550
             E          +E  L   ++E      L S   P  H         AA   R RE L 
Sbjct: 1327 QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELE 1386

Query: 551  SASK----------EHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ 600
             + +            QRE G L    +K  +  +    +LRA    YA++++ LK    
Sbjct: 1387 QSKQAAGGLRAELLRAQRELGELIPLRQKVAEQ-ERTAQQLRAEKASYAEQLSMLKKAHG 1445

Query: 601  QATSENMGLMDN-------WKSKLDSLASDHQKSLEDLKATLNSGPGAQQKE-------I 646
                EN GL +         + +LD     + + L  ++A   +     Q+E       +
Sbjct: 1446 LLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAREL 1505

Query: 647  GELKAVMEGIKMEHQLELGNLQAKHDLETAM----------HVKEKEALREKLQEAQEEL 696
              + A  EG K++   E    Q +    TA             K+ E L +KL ++ +  
Sbjct: 1506 EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQAS 1565

Query: 697  AGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAI----EFL 752
               Q+  +A ++ Q  + + E Q  Q Q  + + ++ + E+    Y+ Q +      +  
Sbjct: 1566 KVQQQKLKA-VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAK 1624

Query: 753  KEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALC---SSQHTHMI 809
            K+Q    ++++   E+LQ+   + + E E L  +L  A  + +  E  C   ++Q   + 
Sbjct: 1625 KQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLE 1684

Query: 810  ESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSG 863
                 +++ +R     +   D L  R+ +          L   + +L+  C+ G
Sbjct: 1685 AQVAHADQQLRDLGKFQVATDALKSREPQA------KPQLDLSIDSLDLSCEEG 1732



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 139/638 (21%), Positives = 253/638 (39%), Gaps = 94/638 (14%)

Query: 457  GDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRR 516
            GD+    Q +  R   L++ L  E++  + L  ELA+NR     + +++  +++ +  R 
Sbjct: 206  GDILQTPQFQMRR---LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRID-RL 261

Query: 517  GEIEELQQCLLHSGPPPPDHPDAAEILR-----LRERLLSASKEHQRESGVLRDKYEKAL 571
              + E Q          P  P   E LR     L  RL    K+ Q +    + + ++ +
Sbjct: 262  ALLNEKQAA-------SPLEPKELEELRDKNESLTMRLHETLKQCQ-DLKTEKSQMDRKI 313

Query: 572  KAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDL 631
                 E   L     ++A  +  L+D + + T E+      W  K   L  +   +L+D 
Sbjct: 314  NQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDK 373

Query: 632  K--------------------ATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGN---LQ 668
            K                    + L   P  ++ E+      +E +K E      N   LQ
Sbjct: 374  KCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQ 433

Query: 669  AKHD-LETAMHVKEKEALREK--LQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQR 725
            A+ + LET    +E + L E+   +E +++L+ L    ++ +    SQ + EL++A  Q 
Sbjct: 434  ARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSIS-NLSQAKEELEQA-SQA 491

Query: 726  RDAELRVH------ELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQG-KQ 778
              A L         EL  L+   + Q Q +  LK+Q    + ++    + Q   +QG + 
Sbjct: 492  HGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRH 551

Query: 779  EVESLREKLLVAENRLQAV-EALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDK 837
            +VE L   L   E +L+ V E   +++  H  +    +EE   +    +    +L   +K
Sbjct: 552  QVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEK 611

Query: 838  EVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEK-------RRLEAELETVSRKTHD 890
            E  A   + E+L+ Q+        S +  V    +EK         L+A +ET  ++ H+
Sbjct: 612  EKAA---KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHE 668

Query: 891  ASGQLVLI-------SQELLRKER------SLNELRVLLLEANRHSPGPERDLSREVHKA 937
            A  Q+  +        Q+   KER       L E    L E+ + + G    L  E  +A
Sbjct: 669  AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG---SLEEEKRRA 725

Query: 938  EWRIKEQ-----KLKDDIRGLREKLTGLDKEKSLSDQR--------RYSLIDPSSAPELL 984
               ++EQ     +LK + R L E+     + K L ++R        R   +  +   E  
Sbjct: 726  ADALEEQQRCISELKAETRSLVEQ--HKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783

Query: 985  RLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQ 1022
             L+ +L     A   A  + +Q+ K + A R   + +Q
Sbjct: 784  VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  117 bits (293), Expect = 6e-26
 Identities = 150/698 (21%), Positives = 297/698 (42%), Gaps = 81/698 (11%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERD----LERAEVAKATSHICEVEK 394
            LTE  +     I+  T  ++AL+E  QQ ++ L AE D    L +A++ K    + ++E 
Sbjct: 984  LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI-KLEQQVDDLEG 1042

Query: 395  EIAL---LKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEE 451
             +     L+   E+   + E  L+ A+  +  +  EK  L  +L+++  ++ +LQ ++E+
Sbjct: 1043 SLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIED 1102

Query: 452  ESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELAD--NRLTTVAEKSRVLQLE 509
            E      L+ + +   ARI ELE+ +  E+A   +  ++ +D    L  ++E+     LE
Sbjct: 1103 EQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER-----LE 1157

Query: 510  EELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEK 569
            E       +IE              +    AE  ++R  L  A+ +H+  +  LR K+  
Sbjct: 1158 EAGGATSAQIE-------------MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204

Query: 570  ALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLE 629
            ++     ++D L+   +K  +E + +K ++    S N+  +   K  L+ +     ++LE
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS-NVETVSKAKGNLEKMC----RTLE 1259

Query: 630  DLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKL 689
            D  + L S    QQ+ I +L A           + G LQ +   E +  + EKEAL  +L
Sbjct: 1260 DQLSELKSKEEEQQRLINDLTA-----------QRGRLQTESG-EFSRQLDEKEALVSQL 1307

Query: 690  QEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAI 749
               ++         + QLE +           Q  R D +L       L  +Y  + ++ 
Sbjct: 1308 SRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL-------LREQYEEEQESK 1360

Query: 750  EFLKEQISLAEKKMLDYERLQRAEA-QGKQEVESLREKLL----VAENRLQAVEALCSSQ 804
              L+  +S A  ++  +      +A Q  +E+E  ++KL      AE  ++AV A C+S 
Sbjct: 1361 AELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCAS- 1419

Query: 805  HTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 864
                     + +   R +  VE L   + + +    AL  +       ++  + KC+   
Sbjct: 1420 ---------LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470

Query: 865  KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSP 924
             +++A  KE R L  EL  +     ++  QL  + +E    ++ +++L   + E  +   
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH 1530

Query: 925  GPER----------DLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSL 974
              E+          +L   + +AE  ++ ++ K  I  ++ +L  +  E       +   
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGK--ILRIQLELNQVKSEVDRKIAEKDEE 1588

Query: 975  IDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLME 1012
            ID       +R+   + ST DA   + + A +++K ME
Sbjct: 1589 IDQLKRNH-IRIVESMQSTLDAEIRSRNDAIRLKKKME 1625



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 153/735 (20%), Positives = 300/735 (40%), Gaps = 88/735 (11%)

Query: 332  GRPSRSGLLTETSSRYARKISGTTALQEA-LKEKQQHIEQLLAERDLERAEVAKATSHIC 390
            G PSR  L  +   RY  K+   +A+ E    + ++  E+LLA  D++  +     + + 
Sbjct: 714  GFPSRI-LYADFKQRY--KVLNASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVF 770

Query: 391  EVEKEIALLKAQHEQYVAEAEEKLQ-RARLLVESVRKEKVDLSNQLEEERRKVEDLQFRV 449
                 + LL+   +  +A+   + Q R R  +  V  ++      + E R  +  +Q+ +
Sbjct: 771  FKAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQR------MVERREAIFCIQYNI 824

Query: 450  EEESITKGD-------------LETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRL 496
                  K                  +T+ E A + E  Q +  E A++E   +EL +  +
Sbjct: 825  RSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMV 884

Query: 497  TTVAEKSRV-LQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKE 555
            T + EK+ + LQ++ E        E   Q +             A+I  + ER     +E
Sbjct: 885  TLLKEKNDLQLQVQAEAEGLADAEERCDQLI------KTKIQLEAKIKEVTER-AEDEEE 937

Query: 556  HQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKS 615
               E    + K E      + ++D L     K  +E    ++KV+  T E  GL D   +
Sbjct: 938  INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL-DETIA 996

Query: 616  KL----DSLASDHQKSLEDLKA------TLNSGPGAQQKEIGELKAVME-GIKMEHQLEL 664
            KL     +L   HQ++L+DL+A      TL       ++++ +L+  +E   K+   LE 
Sbjct: 997  KLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLER 1056

Query: 665  GNLQAKHDLETAMH-----VKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQ 719
               + + DL+ A         EK+ L EKL++ + E++ LQ    +++E    +  L +Q
Sbjct: 1057 AKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQ----SKIE---DEQALGIQ 1109

Query: 720  EAQDQRRDAELRVHEL-EKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRA------ 772
              Q + ++ + R+ EL E+++ E   +A+A    K++  L+ +     ERL+ A      
Sbjct: 1110 -LQKKIKELQARIEELEEEIEAERASRAKA---EKQRSDLSRELEEISERLEEAGGATSA 1165

Query: 773  --EAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQD 830
              E   K+E E  + +  + E  LQ      + +  H     ++ E+    +   + L+ 
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225

Query: 831  KLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD 890
            + ++   E+  L S  E +      LE  C++ E ++         L+++ E   R  +D
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS-------ELKSKEEEQQRLIND 1278

Query: 891  ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDI 950
             + Q   +  E     R L+E   L+ + +R          ++    +    +++L+++I
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSR---------GKQAFTQQIEELKRQLEEEI 1329

Query: 951  RGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDA---LRDALDQAQQV 1007
            +        L   +   D  R    +   +   L+      +TE A    +   D  Q+ 
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389

Query: 1008 EKLMEAMRSCPDKAQ 1022
            E+L EA +    + Q
Sbjct: 1390 EELEEAKKKLAQRLQ 1404



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 141/647 (21%), Positives = 270/647 (41%), Gaps = 116/647 (17%)

Query: 332  GRPSRSGLLTETSSRYARKISGTTALQEALKE--------KQQHIEQLLAERDLERAEVA 383
            G+ + +  + E   +   +I    AL  AL+         ++Q+ E+  ++ +L+RA ++
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRA-LS 1368

Query: 384  KATSHICEVEKEIALLKAQHEQYVAEAEEKL----QRARLLVESVRKEKVDLSNQLEEER 439
            KA + + +   +      Q  + + EA++KL    Q A   VE+V  +   L    +  +
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428

Query: 440  RKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTV 499
             +VEDL   VE  +     L+ + +     + E +Q      A+ E   +E         
Sbjct: 1429 NEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELF 1488

Query: 500  AEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKE-HQR 558
              K+   +  ++L   + E + LQQ                EI  L E++    K  H+ 
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQ----------------EISDLTEQIAEGGKRIHEL 1532

Query: 559  ESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD 618
            E   ++ + E+     QA +++  A+ E    ++  ++ ++ Q  SE    +     ++D
Sbjct: 1533 EK--IKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590

Query: 619  SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGI--KMEHQLELGNLQAKHDL--- 673
             L  +H + +E +++TL++   ++   I  LK  MEG   +ME QL   N  A   L   
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1649

Query: 674  --------ETAMHVKEKEALREKLQEAQEELAGLQRHWRA-QLEVQASQHRLELQE---- 720
                    +T +H+ +  ALR + ++ +E+LA ++R     Q E++  +  LE  E    
Sbjct: 1650 RNTQGILKDTQIHLDD--ALRSQ-EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706

Query: 721  -AQDQRRDAELRVHEL-----------EKLDVEYRGQAQAIEFLKEQISLAEKK------ 762
             A+ +  DA  RV  L           +KL+ +       +E + ++   AE+K      
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAIT 1766

Query: 763  ---MLDYE---------RLQRAEAQGKQEVESLREKLLVAEN--------RLQAVEALCS 802
               M+  E          L+R +   +Q V+ L+ +L  AE         ++Q +EA   
Sbjct: 1767 DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826

Query: 803  SQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTE--------------M 848
                      ++  E  R  E V+GL+    K ++ V  LT QTE               
Sbjct: 1827 ELE------GEVESEQKRNAEAVKGLR----KHERRVKELTYQTEEDRKNILRLQDLVDK 1876

Query: 849  LRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQL 895
            L+A+V + + + +  E++ +  L + R+L+ ELE    +   A  Q+
Sbjct: 1877 LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQV 1923



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 121/563 (21%), Positives = 236/563 (41%), Gaps = 66/563 (11%)

Query: 481  KAQAERLLRELADNRLTTVAEKSR------VLQLEEELTLRRGEIEELQQCLLHSGPPPP 534
            KA    LL E+ D++L  +  +++      + ++E +  + R E     Q  + S     
Sbjct: 772  KAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVK 831

Query: 535  DHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAG 594
              P      +++  L SA  E ++E   ++++++K          K +   EK    +  
Sbjct: 832  HWPWMKLFFKIKPLLKSA--ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKE 889

Query: 595  LKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVME 654
              D   Q  +E  GL D  + + D L     K+   L+A +       + E  E+ A + 
Sbjct: 890  KNDLQLQVQAEAEGLADA-EERCDQLI----KTKIQLEAKIKEVTERAEDE-EEINAELT 943

Query: 655  GIKMEHQLELGNLQAKHD---LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQA 711
              K + + E   L+   D   L  A   KEK A   K++   EE+AGL      +   + 
Sbjct: 944  AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-----ETIAKL 998

Query: 712  SQHRLELQEAQDQRRD----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKM-LDY 766
            ++ +  LQEA  Q  D     E +V+ L K  ++   Q   +E   EQ    EKK+ +D 
Sbjct: 999  TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ----EKKLRMD- 1053

Query: 767  ERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKE-TV 825
              L+RA+ + + +++  +E ++  EN  Q +                  +E ++ KE  +
Sbjct: 1054 --LERAKRKLEGDLKLAQESIMDIENEKQQL------------------DEKLKKKEFEI 1093

Query: 826  EGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVS 885
              LQ K+         L  + + L+A++  LE + ++         K++  L  ELE +S
Sbjct: 1094 SNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1153

Query: 886  RKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQK 945
             +  +A G      +   ++E    ++R  L EA          L ++   +   + EQ 
Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ- 1212

Query: 946  LKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL-----RLQHQLMSTEDALRDA 1000
              D+++ +++K   L+KEKS   + +  + D +S  E +      L+    + ED L + 
Sbjct: 1213 -IDNLQRVKQK---LEKEKS---EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265

Query: 1001 LDQAQQVEKLMEAMRSCPDKAQT 1023
              + ++ ++L+  + +   + QT
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQT 1288


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  117 bits (293), Expect = 6e-26
 Identities = 150/698 (21%), Positives = 297/698 (42%), Gaps = 81/698 (11%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERD----LERAEVAKATSHICEVEK 394
            LTE  +     I+  T  ++AL+E  QQ ++ L AE D    L +A++ K    + ++E 
Sbjct: 984  LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKI-KLEQQVDDLEG 1042

Query: 395  EIAL---LKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEE 451
             +     L+   E+   + E  L+ A+  +  +  EK  L  +L+++  ++ +LQ ++E+
Sbjct: 1043 SLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIED 1102

Query: 452  ESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELAD--NRLTTVAEKSRVLQLE 509
            E      L+ + +   ARI ELE+ +  E+A   +  ++ +D    L  ++E+     LE
Sbjct: 1103 EQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER-----LE 1157

Query: 510  EELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEK 569
            E       +IE              +    AE  ++R  L  A+ +H+  +  LR K+  
Sbjct: 1158 EAGGATSAQIE-------------MNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204

Query: 570  ALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLE 629
            ++     ++D L+   +K  +E + +K ++    S N+  +   K  L+ +     ++LE
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS-NVETVSKAKGNLEKMC----RTLE 1259

Query: 630  DLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKL 689
            D  + L S    QQ+ I +L A           + G LQ +   E +  + EKEAL  +L
Sbjct: 1260 DQLSELKSKEEEQQRLINDLTA-----------QRGRLQTESG-EFSRQLDEKEALVSQL 1307

Query: 690  QEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAI 749
               ++         + QLE +           Q  R D +L       L  +Y  + ++ 
Sbjct: 1308 SRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDL-------LREQYEEEQESK 1360

Query: 750  EFLKEQISLAEKKMLDYERLQRAEA-QGKQEVESLREKLL----VAENRLQAVEALCSSQ 804
              L+  +S A  ++  +      +A Q  +E+E  ++KL      AE  ++AV A C+S 
Sbjct: 1361 AELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCAS- 1419

Query: 805  HTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 864
                     + +   R +  VE L   + + +    AL  +       ++  + KC+   
Sbjct: 1420 ---------LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470

Query: 865  KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSP 924
             +++A  KE R L  EL  +     ++  QL  + +E    ++ +++L   + E  +   
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH 1530

Query: 925  GPER----------DLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSL 974
              E+          +L   + +AE  ++ ++ K  I  ++ +L  +  E       +   
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGK--ILRIQLELNQVKSEVDRKIAEKDEE 1588

Query: 975  IDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLME 1012
            ID       +R+   + ST DA   + + A +++K ME
Sbjct: 1589 IDQLKRNH-IRIVESMQSTLDAEIRSRNDAIRLKKKME 1625



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 153/735 (20%), Positives = 300/735 (40%), Gaps = 88/735 (11%)

Query: 332  GRPSRSGLLTETSSRYARKISGTTALQEA-LKEKQQHIEQLLAERDLERAEVAKATSHIC 390
            G PSR  L  +   RY  K+   +A+ E    + ++  E+LLA  D++  +     + + 
Sbjct: 714  GFPSRI-LYADFKQRY--KVLNASAIPEGQFIDSKKASEKLLASIDIDHTQYKFGHTKVF 770

Query: 391  EVEKEIALLKAQHEQYVAEAEEKLQ-RARLLVESVRKEKVDLSNQLEEERRKVEDLQFRV 449
                 + LL+   +  +A+   + Q R R  +  V  ++      + E R  +  +Q+ +
Sbjct: 771  FKAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQR------MVERREAIFCIQYNI 824

Query: 450  EEESITKGD-------------LETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRL 496
                  K                  +T+ E A + E  Q +  E A++E   +EL +  +
Sbjct: 825  RSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMV 884

Query: 497  TTVAEKSRV-LQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKE 555
            T + EK+ + LQ++ E        E   Q +             A+I  + ER     +E
Sbjct: 885  TLLKEKNDLQLQVQAEAEGLADAEERCDQLI------KTKIQLEAKIKEVTER-AEDEEE 937

Query: 556  HQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKS 615
               E    + K E      + ++D L     K  +E    ++KV+  T E  GL D   +
Sbjct: 938  INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL-DETIA 996

Query: 616  KL----DSLASDHQKSLEDLKA------TLNSGPGAQQKEIGELKAVME-GIKMEHQLEL 664
            KL     +L   HQ++L+DL+A      TL       ++++ +L+  +E   K+   LE 
Sbjct: 997  KLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLER 1056

Query: 665  GNLQAKHDLETAMH-----VKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQ 719
               + + DL+ A         EK+ L EKL++ + E++ LQ    +++E    +  L +Q
Sbjct: 1057 AKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQ----SKIE---DEQALGIQ 1109

Query: 720  EAQDQRRDAELRVHEL-EKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRA------ 772
              Q + ++ + R+ EL E+++ E   +A+A    K++  L+ +     ERL+ A      
Sbjct: 1110 -LQKKIKELQARIEELEEEIEAERASRAKA---EKQRSDLSRELEEISERLEEAGGATSA 1165

Query: 773  --EAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQD 830
              E   K+E E  + +  + E  LQ      + +  H     ++ E+    +   + L+ 
Sbjct: 1166 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEK 1225

Query: 831  KLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD 890
            + ++   E+  L S  E +      LE  C++ E ++         L+++ E   R  +D
Sbjct: 1226 EKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS-------ELKSKEEEQQRLIND 1278

Query: 891  ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDI 950
             + Q   +  E     R L+E   L+ + +R          ++    +    +++L+++I
Sbjct: 1279 LTAQRGRLQTESGEFSRQLDEKEALVSQLSR---------GKQAFTQQIEELKRQLEEEI 1329

Query: 951  RGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDA---LRDALDQAQQV 1007
            +        L   +   D  R    +   +   L+      +TE A    +   D  Q+ 
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389

Query: 1008 EKLMEAMRSCPDKAQ 1022
            E+L EA +    + Q
Sbjct: 1390 EELEEAKKKLAQRLQ 1404



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 141/647 (21%), Positives = 270/647 (41%), Gaps = 116/647 (17%)

Query: 332  GRPSRSGLLTETSSRYARKISGTTALQEALKE--------KQQHIEQLLAERDLERAEVA 383
            G+ + +  + E   +   +I    AL  AL+         ++Q+ E+  ++ +L+RA ++
Sbjct: 1310 GKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRA-LS 1368

Query: 384  KATSHICEVEKEIALLKAQHEQYVAEAEEKL----QRARLLVESVRKEKVDLSNQLEEER 439
            KA + + +   +      Q  + + EA++KL    Q A   VE+V  +   L    +  +
Sbjct: 1369 KANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQ 1428

Query: 440  RKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTV 499
             +VEDL   VE  +     L+ + +     + E +Q      A+ E   +E         
Sbjct: 1429 NEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELF 1488

Query: 500  AEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKE-HQR 558
              K+   +  ++L   + E + LQQ                EI  L E++    K  H+ 
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQ----------------EISDLTEQIAEGGKRIHEL 1532

Query: 559  ESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD 618
            E   ++ + E+     QA +++  A+ E    ++  ++ ++ Q  SE    +     ++D
Sbjct: 1533 EK--IKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590

Query: 619  SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGI--KMEHQLELGNLQAKHDL--- 673
             L  +H + +E +++TL++   ++   I  LK  MEG   +ME QL   N  A   L   
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1649

Query: 674  --------ETAMHVKEKEALREKLQEAQEELAGLQRHWRA-QLEVQASQHRLELQE---- 720
                    +T +H+ +  ALR + ++ +E+LA ++R     Q E++  +  LE  E    
Sbjct: 1650 RNTQGILKDTQIHLDD--ALRSQ-EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1706

Query: 721  -AQDQRRDAELRVHEL-----------EKLDVEYRGQAQAIEFLKEQISLAEKK------ 762
             A+ +  DA  RV  L           +KL+ +       +E + ++   AE+K      
Sbjct: 1707 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAIT 1766

Query: 763  ---MLDYE---------RLQRAEAQGKQEVESLREKLLVAEN--------RLQAVEALCS 802
               M+  E          L+R +   +Q V+ L+ +L  AE         ++Q +EA   
Sbjct: 1767 DAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVR 1826

Query: 803  SQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTE--------------M 848
                      ++  E  R  E V+GL+    K ++ V  LT QTE               
Sbjct: 1827 ELE------GEVESEQKRNAEAVKGLR----KHERRVKELTYQTEEDRKNILRLQDLVDK 1876

Query: 849  LRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQL 895
            L+A+V + + + +  E++ +  L + R+L+ ELE    +   A  Q+
Sbjct: 1877 LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQV 1923



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 121/563 (21%), Positives = 236/563 (41%), Gaps = 66/563 (11%)

Query: 481  KAQAERLLRELADNRLTTVAEKSR------VLQLEEELTLRRGEIEELQQCLLHSGPPPP 534
            KA    LL E+ D++L  +  +++      + ++E +  + R E     Q  + S     
Sbjct: 772  KAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREAIFCIQYNIRSFMNVK 831

Query: 535  DHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAG 594
              P      +++  L SA  E ++E   ++++++K          K +   EK    +  
Sbjct: 832  HWPWMKLFFKIKPLLKSA--ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKE 889

Query: 595  LKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVME 654
              D   Q  +E  GL D  + + D L     K+   L+A +       + E  E+ A + 
Sbjct: 890  KNDLQLQVQAEAEGLADA-EERCDQLI----KTKIQLEAKIKEVTERAEDE-EEINAELT 943

Query: 655  GIKMEHQLELGNLQAKHD---LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQA 711
              K + + E   L+   D   L  A   KEK A   K++   EE+AGL      +   + 
Sbjct: 944  AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-----ETIAKL 998

Query: 712  SQHRLELQEAQDQRRD----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKM-LDY 766
            ++ +  LQEA  Q  D     E +V+ L K  ++   Q   +E   EQ    EKK+ +D 
Sbjct: 999  TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ----EKKLRMD- 1053

Query: 767  ERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKE-TV 825
              L+RA+ + + +++  +E ++  EN  Q +                  +E ++ KE  +
Sbjct: 1054 --LERAKRKLEGDLKLAQESIMDIENEKQQL------------------DEKLKKKEFEI 1093

Query: 826  EGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVS 885
              LQ K+         L  + + L+A++  LE + ++         K++  L  ELE +S
Sbjct: 1094 SNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1153

Query: 886  RKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQK 945
             +  +A G      +   ++E    ++R  L EA          L ++   +   + EQ 
Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ- 1212

Query: 946  LKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL-----RLQHQLMSTEDALRDA 1000
              D+++ +++K   L+KEKS   + +  + D +S  E +      L+    + ED L + 
Sbjct: 1213 -IDNLQRVKQK---LEKEKS---EMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265

Query: 1001 LDQAQQVEKLMEAMRSCPDKAQT 1023
              + ++ ++L+  + +   + QT
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQT 1288


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  113 bits (282), Expect = 1e-24
 Identities = 159/723 (21%), Positives = 307/723 (42%), Gaps = 121/723 (16%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERDLERAEVAKATSHICEVEKEIAL 398
            LTE  +     I+  T  ++AL+E  QQ ++ L AE D    +V   T    ++E+++  
Sbjct: 982  LTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED----KVNTLTKAKIKLEQQVDD 1037

Query: 399  LKAQHEQY------VAEAEEKLQRARLLVES----VRKEKVDLSNQLEEERRKVEDLQFR 448
            L+   EQ       +  A+ KL+    L +     +  +K  L  +L+++  ++  LQ +
Sbjct: 1038 LEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSK 1097

Query: 449  VEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELAD--NRLTTVAEKSRVL 506
            +E+E      L+ + +   ARI ELE+ +  E+A   +  ++ +D    L  ++E+    
Sbjct: 1098 IEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER---- 1153

Query: 507  QLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDK 566
             LEE       +IE              +    AE  ++R  L  A+ +H+  +  LR K
Sbjct: 1154 -LEEAGGATSAQIE-------------MNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199

Query: 567  YEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLA----- 621
            +  ++     ++D L+   +K  +E + +K ++    S NM  +   K  L+ +      
Sbjct: 1200 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS-NMETVSKAKGNLEKMCRALED 1258

Query: 622  ---------SDHQKSLEDL---KATLNSGPGAQQKEIGELKAVMEGI------------K 657
                      + Q+ + DL   +A L +  G   +++ E   ++  +            +
Sbjct: 1259 QLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318

Query: 658  MEHQLELGNLQAK----HDLETAMHVKEKEALREKLQEAQEELAGLQR----------HW 703
            ++ QLE   ++AK    H L+++ H  + + LRE+ +E QE  A LQR           W
Sbjct: 1319 LKRQLE-EEIKAKSALAHALQSSRH--DCDLLREQYEEEQEAKAELQRAMSKANSEVAQW 1375

Query: 704  RAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQI-SLAEKK 762
            R + E  A Q   EL+EA   ++    R+ + E+       +  ++E  K+++ +  E  
Sbjct: 1376 RTKYETDAIQRTEELEEA---KKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1432

Query: 763  MLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHM----IESNDISEET 818
            M+D ER   A A       +L +K    +  L   +  C   H  +     ES  +S E 
Sbjct: 1433 MIDVERTNAACA-------ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTEL 1485

Query: 819  IRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLE 878
             + K   E   D+L         L  + + L+ ++S L  +   G K++  L K K+++E
Sbjct: 1486 FKIKNAYEESLDQLE-------TLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 1538

Query: 879  AELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAE 938
             E   +     +A   L     ++LR +  LN+++               ++ R++ + +
Sbjct: 1539 QEKSELQAALEEAEASLEHEEGKILRIQLELNQVK--------------SEVDRKIAEKD 1584

Query: 939  WRIKEQKLKDDIRGLREKLTGLDKE-KSLSDQRRYSLIDPSSAPEL-LRLQHQLMSTEDA 996
              I + K ++ IR +    + LD E +S +D  R          E+ ++L H      +A
Sbjct: 1585 EEIDQMK-RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEA 1643

Query: 997  LRD 999
            LR+
Sbjct: 1644 LRN 1646



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 139/641 (21%), Positives = 271/641 (42%), Gaps = 104/641 (16%)

Query: 332  GRPSRSGLLTETSSRYARKISGTTALQEALKE--------KQQHIEQLLAERDLERAEVA 383
            G+ + +  + E   +   +I   +AL  AL+         ++Q+ E+  A+ +L+RA ++
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRA-MS 1366

Query: 384  KATSHICEVEKEIALLKAQHEQYVAEAEEKL----QRARLLVESVRKEKVDLSNQLEEER 439
            KA S + +   +      Q  + + EA++KL    Q A   VE+V  +   L    +  +
Sbjct: 1367 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQ 1426

Query: 440  RKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTV 499
             +VEDL   VE  +     L+ + +     + E +Q      A+ E   +E         
Sbjct: 1427 NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELF 1486

Query: 500  AEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKE-HQR 558
              K+   +  ++L   + E + LQQ                EI  L E++    K  H+ 
Sbjct: 1487 KIKNAYEESLDQLETLKRENKNLQQ----------------EISDLTEQIAEGGKRIHEL 1530

Query: 559  ESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD 618
            E   ++ + E+     QA +++  A+ E    ++  ++ ++ Q  SE    +     ++D
Sbjct: 1531 EK--IKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1588

Query: 619  SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGI--KMEHQLELGNLQAKHDL--- 673
             +  +H + +E +++TL++   ++   I  LK  MEG   +ME QL   N  A   L   
Sbjct: 1589 QMKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1647

Query: 674  --------ETAMHVKEKEALREKLQEAQEELAGLQRHWRA-QLEVQASQHRLELQE---- 720
                    +T +H+ +  ALR + ++ +E+LA ++R     Q E++  +  LE  E    
Sbjct: 1648 RNTQAILKDTQLHLDD--ALRSQ-EDLKEQLAMVERRANLLQAEIEELRATLEQTERSRK 1704

Query: 721  -AQDQRRDAELRVHEL-----------EKLDVEY---RGQAQAI--------EFLKEQIS 757
             A+ +  DA  RV  L           +KL+ +    +G+ + I        E  K+ I+
Sbjct: 1705 IAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAIT 1764

Query: 758  LAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIES------ 811
             A     + ++ Q   A  ++  ++L + +   ++RL   E L        I+       
Sbjct: 1765 DAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVR 1824

Query: 812  ---NDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTE--------------MLRAQVS 854
                ++  E  R  E V+GL+    K +++V  LT QTE               L+A+V 
Sbjct: 1825 ELEGEVESEQKRNVEAVKGLR----KHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVK 1880

Query: 855  ALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQL 895
            + + + +  E++ +  L + RR++ ELE    +   A  Q+
Sbjct: 1881 SYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQV 1921



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 151/728 (20%), Positives = 299/728 (41%), Gaps = 114/728 (15%)

Query: 361  LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL 420
            +KE+ +  ++ LA+ + +R E+ +    + + + ++ L        +A+AEE+       
Sbjct: 856  MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERC------ 909

Query: 421  VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLE 480
             + + K K+ L  +++E   + ED +    E +  K  LE +       I +LE  L L 
Sbjct: 910  -DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE--LTLA 966

Query: 481  KAQAERLLRELADNRLTTVAEKSRVL-QLEEELTLRRGEIEELQQCLLHSGPPPPDHPDA 539
            K + E   +   +N++  + E+   L +   +LT  +  ++E  Q  L       D  + 
Sbjct: 967  KVEKE---KHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023

Query: 540  AEILRLR--------ERLLSASKEHQRESGVLRDKYEKALKAYQ-----AEVDK--LRAA 584
                +++        E  L   K+ + +    + K E  LK  Q      E DK  L   
Sbjct: 1024 LTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEK 1083

Query: 585  NEKYAQEVAGLKDKVQQATSENMGLMDNWK--------------------SKLDSLASDH 624
             +K   E++GL+ K++   +  M L    K                    +K +   SD 
Sbjct: 1084 LKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1143

Query: 625  QKSLEDLKATLNSGPGAQQKEIG-ELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKE 683
             + LE++   L    GA   +I    K   E  KM   LE   LQ +    TA  +++K 
Sbjct: 1144 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHE---ATAATLRKKH 1200

Query: 684  ALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQE---------------------AQ 722
            A  + + E  E++  LQR  + +LE + S+ ++E+ +                      +
Sbjct: 1201 A--DSVAELGEQIDNLQR-VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE 1257

Query: 723  DQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQIS--LAEKKMLDYERLQRAEAQGKQEV 780
            DQ  + + +  E ++L  +   Q   ++    + S  L EK  L   +L R +    Q++
Sbjct: 1258 DQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL-VSQLSRGKQAFTQQI 1316

Query: 781  ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEV- 839
            E L+ +L   E  ++A  AL  +  +   + + + E+    +E    LQ  ++K + EV 
Sbjct: 1317 EELKRQL---EEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVA 1373

Query: 840  -------TALTSQTEMLRAQVSALESKCKSGEKKVDA-------LLKEKRRLEAELETVS 885
                   T    +TE L      L  + +  E+ V+A       L K K+RL+ E+E + 
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1433

Query: 886  RKTHDASGQLVLISQELLRKERSLNELRVLLLEANRH---SPGPERDLSREVHKAEWRIK 942
                  +     + ++    ++ L E +    E +     S    R LS E+ K +   +
Sbjct: 1434 IDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYE 1493

Query: 943  E-----QKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDAL 997
            E     + LK + + L+++++ L ++ +   +R +         EL +++ Q+   +  L
Sbjct: 1494 ESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH---------ELEKIKKQVEQEKSEL 1544

Query: 998  RDALDQAQ 1005
            + AL++A+
Sbjct: 1545 QAALEEAE 1552



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 124/583 (21%), Positives = 246/583 (42%), Gaps = 50/583 (8%)

Query: 462  QTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRV-LQLEEELTLRRGEIE 520
            +T+ E A + E  +    E A+ E   +EL +  +T + EK+ + LQ++ E        E
Sbjct: 848  ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907

Query: 521  ELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDK 580
               Q +             A+I  + ER     +E   E    + K E      + ++D 
Sbjct: 908  RCDQLI------KTKIQLEAKIKEVTER-AEDEEEINAELTAKKRKLEDECSELKKDIDD 960

Query: 581  LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKL----DSLASDHQKSLEDLKA--- 633
            L     K  +E    ++KV+  T E  GL D   +KL     +L   HQ++L+DL+A   
Sbjct: 961  LELTLAKVEKEKHATENKVKNLTEEMAGL-DETIAKLTKEKKALQEAHQQTLDDLQAEED 1019

Query: 634  ---TLNSGPGAQQKEIGELKAVME-GIKMEHQLELGNLQAKHDL----ETAMHVK-EKEA 684
               TL       ++++ +L+  +E   K+   LE    + + DL    E+ M ++ +K+ 
Sbjct: 1020 KVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQ 1079

Query: 685  LREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHEL-EKLDVEYR 743
            L EKL++ + E++GLQ    +++E    +  L +Q  Q + ++ + R+ EL E+++ E  
Sbjct: 1080 LDEKLKKKEFEMSGLQ----SKIE---DEQALGMQ-LQKKIKELQARIEELEEEIEAERA 1131

Query: 744  GQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVE-SLREKLLVAENRLQAVEALCS 802
             +A+A    K++  L+ +     ERL+ A      ++E + + +    + R    EA   
Sbjct: 1132 SRAKA---EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188

Query: 803  SQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKS 862
             + T        ++      E ++ LQ    K +KE + +  + + L + +  +     +
Sbjct: 1189 HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGN 1248

Query: 863  GEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRH 922
             EK   AL  +   ++ + E   R  +D + Q   +  E     R L+E   L+ + +R 
Sbjct: 1249 LEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSR- 1307

Query: 923  SPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPE 982
                     ++    +    +++L+++I+        L   +   D  R    +   A  
Sbjct: 1308 --------GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKA 1359

Query: 983  LLRLQHQLMSTEDA---LRDALDQAQQVEKLMEAMRSCPDKAQ 1022
             L+      ++E A    +   D  Q+ E+L EA +    + Q
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1402



 Score = 70.5 bits (171), Expect = 8e-12
 Identities = 110/495 (22%), Positives = 214/495 (43%), Gaps = 72/495 (14%)

Query: 550  LSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGL 609
            L  S E ++E   +++++EK     + E+ K  A  ++       L++K+     E   L
Sbjct: 843  LLKSAETEKEMANMKEEFEKT----KEELAKTEAKRKE-------LEEKMVTLMQEKNDL 891

Query: 610  MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKME-----HQLEL 664
                +++ DSLA   ++  + +K  +     A+ KE+ E     E I  E      +LE 
Sbjct: 892  QLQVQAEADSLADAEERCDQLIKTKIQLE--AKIKEVTERAEDEEEINAELTAKKRKLED 949

Query: 665  GNLQAKHDLET-----AMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQ 719
               + K D++      A   KEK A   K++   EE+AGL      +   + ++ +  LQ
Sbjct: 950  ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-----ETIAKLTKEKKALQ 1004

Query: 720  EAQDQRRD----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKM-LDYERLQRAEA 774
            EA  Q  D     E +V+ L K  ++   Q   +E   EQ    EKK+ +D   L+RA+ 
Sbjct: 1005 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ----EKKIRMD---LERAKR 1057

Query: 775  QGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKE-TVEGLQDKLN 833
            + + +++  +E  +  EN  Q +                  +E ++ KE  + GLQ K+ 
Sbjct: 1058 KLEGDLKLAQESTMDIENDKQQL------------------DEKLKKKEFEMSGLQSKIE 1099

Query: 834  KRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASG 893
                    L  + + L+A++  LE + ++         K++  L  ELE +S +  +A G
Sbjct: 1100 DEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGG 1159

Query: 894  QLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGL 953
                  +   ++E    ++R  L EA          L ++   +   + EQ   D+++ +
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ--IDNLQRV 1217

Query: 954  REKLTGLDKEKSLSDQRRYSLIDPSSAPELL-----RLQHQLMSTEDALRDALDQAQQVE 1008
            ++K   L+KEKS   + +  + D +S  E +      L+    + ED L +   + ++ +
Sbjct: 1218 KQK---LEKEKS---EMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQ 1271

Query: 1009 KLMEAMRSCPDKAQT 1023
            +L+  + +   + QT
Sbjct: 1272 RLINDLTAQRARLQT 1286



 Score = 60.5 bits (145), Expect = 8e-09
 Identities = 54/221 (24%), Positives = 100/221 (45%), Gaps = 12/221 (5%)

Query: 797  VEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL 856
            ++ L  S  T   E  ++ EE  +TKE +   + K  + ++++  L  +   L+ QV A 
Sbjct: 840  IKPLLKSAETEK-EMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898

Query: 857  ESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL 916
                   E++ D L+K K +LEA+++ V+ +  D       I+ EL  K+R L +    L
Sbjct: 899  ADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE----INAELTAKKRKLEDECSEL 954

Query: 917  LEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID 976
             +           + +E H  E ++K   L +++ GL E +  L KEK    +     +D
Sbjct: 955  KKDIDDLELTLAKVEKEKHATENKVK--NLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1012

Query: 977  PSSAPE-----LLRLQHQLMSTEDALRDALDQAQQVEKLME 1012
               A E     L + + +L    D L  +L+Q +++   +E
Sbjct: 1013 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  112 bits (281), Expect = 1e-24
 Identities = 179/812 (22%), Positives = 343/812 (42%), Gaps = 162/812 (19%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            LTE  +     I+  T  ++AL+E  Q   Q L +  +E  +V   T    ++E+++  L
Sbjct: 982  LTEEMAGLDETIAKLTKEKKALQEAHQ---QTLDDLQMEEDKVNTLTKAKTKLEQQVDDL 1038

Query: 400  KAQHEQY------VAEAEEKLQRARLLVES----VRKEKVDLSNQLEEERRKVEDLQFRV 449
            +   EQ       +  A+ KL+    L +        +K  L+ +L+++  ++ +LQ ++
Sbjct: 1039 EGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKI 1098

Query: 450  EEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELAD--NRLTTVAEKSRVLQ 507
            E+E      L+ + +   ARI ELE+ +  E+A   +  ++ +D    L  ++E+     
Sbjct: 1099 EDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER----- 1153

Query: 508  LEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKY 567
            LEE       +IE  ++               AE  ++R  L  ++ +H+  +  LR K+
Sbjct: 1154 LEEAGGATSAQIEMNKK-------------REAEFQKMRRDLEESTLQHEATAAALRKKH 1200

Query: 568  EKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKS 627
              ++     ++D L+   +K  +E + LK ++    S NM  +   K+  + +    +  
Sbjct: 1201 ADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLAS-NMETVSKAKANFEKMCRTLEDQ 1259

Query: 628  LEDLK-----------------ATLNSGPGAQQKEIGELKAVMEGI------------KM 658
            L ++K                 A L++  G   +++ E  A++  +            ++
Sbjct: 1260 LSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEEL 1319

Query: 659  EHQLELGNLQAK----HDLETAMHVKEKEALREKLQEAQEELAGLQR----------HWR 704
            + QLE    +AK    H L++A H  + + LRE+ +E QE  A LQR           WR
Sbjct: 1320 KRQLE-EETKAKSTLAHALQSARH--DCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR 1376

Query: 705  AQLEVQASQHRLELQEAQ----DQRRDAELRVH-------ELEK-------------LDV 740
             + E  A Q   EL+EA+     + +DAE  V         LEK             +DV
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDV 1436

Query: 741  EYRGQAQAIEFLKEQIS----LAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENR--- 793
            E R  A  I   K+Q +    LAE K   YE  Q      ++E  SL  +L   +N    
Sbjct: 1437 E-RSNAACIALDKKQRNFDKVLAEWKQ-KYEETQAELEASQKESRSLSTELFKVKNAYEE 1494

Query: 794  -LQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTE----- 847
             L  +E L         E +D++E+     + +  L+    + D E + L +  E     
Sbjct: 1495 SLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEAS 1554

Query: 848  -------MLRAQV------SALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQ 894
                   +LR Q+      S ++ K    ++++D L +   R+   +++       +   
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRND 1614

Query: 895  LVLISQELLRKERSLNELRVLLLEANRHSPGPERDL--------SREVH-----KAEWRI 941
             + I +++   E  LNE+ + L  ANR +    R+L          ++H     + +  +
Sbjct: 1615 ALRIKKKM---EGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDL 1671

Query: 942  KEQ---------KLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQH-QLM 991
            KEQ          ++ ++  LR  L   ++ + +++Q    L+D S   +LL  Q+  L+
Sbjct: 1672 KEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQ---ELLDASERVQLLHTQNTSLI 1728

Query: 992  STEDALRDALDQAQ-QVEKLMEAMRSCPDKAQ 1022
            +T+  L   + Q Q ++E +++  R+  +KA+
Sbjct: 1729 NTKKKLETDISQIQGEMEDIVQEARNAEEKAK 1760



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 108/480 (22%), Positives = 211/480 (43%), Gaps = 51/480 (10%)

Query: 462  QTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRV-LQLEEELTLRRGEIE 520
            +T+ E A + E  +    E A+ E   +EL +  +T + EK+ + LQ++ E        E
Sbjct: 848  ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907

Query: 521  ELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDK 580
               Q +             A+I  + ER     +E   E    + K E      + ++D 
Sbjct: 908  RCDQLI------KTKIQLEAKIKEVTER-AEDEEEINAELTAKKRKLEDECSELKKDIDD 960

Query: 581  LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKL----DSLASDHQKSLEDLKA--- 633
            L     K  +E    ++KV+  T E  GL D   +KL     +L   HQ++L+DL+    
Sbjct: 961  LELTLAKVEKEKHATENKVKNLTEEMAGL-DETIAKLTKEKKALQEAHQQTLDDLQMEED 1019

Query: 634  ---TLNSGPGAQQKEIGELKAVME-GIKMEHQLELGNLQAKHDLETAMH-----VKEKEA 684
               TL       ++++ +L+  +E   K+   LE    + + DL+ A         +K+ 
Sbjct: 1020 KVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQ 1079

Query: 685  LREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHEL-EKLDVEYR 743
            L EKL++ + E++ LQ     ++E    +  L +Q  Q + ++ + R+ EL E+++ E  
Sbjct: 1080 LNEKLKKKEFEMSNLQ----GKIE---DEQALAIQ-LQKKIKELQARIEELEEEIEAERA 1131

Query: 744  GQAQAIEFLKEQISLAEKKMLDYERLQRA--------EAQGKQEVESLREKLLVAENRLQ 795
             +A+A    K++  L+ +     ERL+ A        E   K+E E  + +  + E+ LQ
Sbjct: 1132 SRAKA---EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQ 1188

Query: 796  AVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSA 855
                  + +  H     ++ E+    +   + L+ + ++   E+  L S  E +    + 
Sbjct: 1189 HEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKAN 1248

Query: 856  LESKCKSGEKKVDALL---KEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNEL 912
             E  C++ E ++  +    +E++RL  EL     + H  SG+    S++L  K+  +++L
Sbjct: 1249 FEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGE---FSRQLDEKDAMVSQL 1305



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 138/617 (22%), Positives = 260/617 (42%), Gaps = 108/617 (17%)

Query: 356  ALQEALKE----KQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            ALQ A  +    ++Q+ E+  A+ +L+R  ++KA S + +   +      Q  + + EA+
Sbjct: 1336 ALQSARHDCDLLREQYEEEQEAKAELQRG-MSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 412  EKL----QRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEH 467
            +KL    Q A   VE+V  +   L    +  + +VEDL   VE  +     L+ + +   
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFD 1454

Query: 468  ARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLE--EELTLRRGEIEELQQC 525
              + E +Q    E+ QAE    +     L+T   K +    E  + L   + E + LQQ 
Sbjct: 1455 KVLAEWKQKY--EETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQ- 1511

Query: 526  LLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAAN 585
                           EI  L E++    K H  E   ++ + +      Q  +++  A+ 
Sbjct: 1512 ---------------EISDLTEQIAEGGK-HIHELEKVKKQLDHEKSELQTSLEEAEASL 1555

Query: 586  EKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKE 645
            E    ++  ++ ++ Q  SE    +     +LD L  +H + +E +++TL++   ++   
Sbjct: 1556 EHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDA 1615

Query: 646  IGELKAVMEGI--KMEHQLELGNLQAKHDL-----------ETAMH----VKEKEALREK 688
            +  +K  MEG   +ME QL   N QA   L           +T +H    ++ ++ L+E+
Sbjct: 1616 L-RIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQ 1674

Query: 689  LQ-----------EAQEELAGLQRHWR----AQLEVQASQHRLELQEAQDQ--------- 724
            L            E +E  A L+R  R    A+ E+  +  R++L   Q+          
Sbjct: 1675 LAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKL 1734

Query: 725  RRDAELRVHELEKLDVEYRG-QAQAIEFLKEQISLAEKKMLDYE---RLQRAEAQGKQEV 780
              D      E+E +  E R  + +A + + +   +AE+   + +    L+R +   +Q V
Sbjct: 1735 ETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTV 1794

Query: 781  ESLREKLLVAEN--------RLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKL 832
            + L+ +L  AE         ++Q +EA         +ES ++  E     E V+GL+   
Sbjct: 1795 KDLQLRLDEAEQLALKGGKKQIQKLEA-----RVRELES-EVESEQKHNVEAVKGLR--- 1845

Query: 833  NKRDKEVTALTSQTE--------------MLRAQVSALESKCKSGEKKVDALLKEKRRLE 878
             K ++ V  LT QTE               L+ +V A + + +  E++ +  L + R+L+
Sbjct: 1846 -KHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQ 1904

Query: 879  AELETVSRKTHDASGQL 895
             ELE    +   A  Q+
Sbjct: 1905 HELEEAKERADIAESQV 1921



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 64/305 (20%), Positives = 137/305 (44%), Gaps = 19/305 (6%)

Query: 673  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV-------QASQHRLELQEAQDQR 725
            L++A   KE   ++E+ ++ +EELA  +   R +LE        + +  +L++Q   D  
Sbjct: 844  LKSAETEKEMANMKEEFEKTKEELAKTEAK-RKELEEKMVTLMQEKNDLQLQVQAEADAL 902

Query: 726  RDAELRVHELEKLDVEYRGQAQAI-EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLR 784
             DAE R  +L K  ++   + + + E  +++  +  +      +L+   ++ K++++ L 
Sbjct: 903  ADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE 962

Query: 785  EKLLVAENRLQAVEALCSSQHTHMIESND----ISEETIRTKETVEGLQDKLNKRDKEVT 840
              L   E    A E    +    M   ++    +++E    +E  +   D L   + +V 
Sbjct: 963  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVN 1022

Query: 841  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 900
             LT     L  QV  LE   +  +K    L + KR+LE +L+     T D       +++
Sbjct: 1023 TLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNE 1082

Query: 901  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 960
            +L +KE  ++ L+  + +    +      L +++ + + RI+E  L+++I   R      
Sbjct: 1083 KLKKKEFEMSNLQGKIEDEQALA----IQLQKKIKELQARIEE--LEEEIEAERASRAKA 1136

Query: 961  DKEKS 965
            +K++S
Sbjct: 1137 EKQRS 1141



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 93/441 (21%), Positives = 179/441 (40%), Gaps = 71/441 (16%)

Query: 550  LSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGL 609
            L  S E ++E   +++++EK     + E+ K  A  ++       L++K+     E   L
Sbjct: 843  LLKSAETEKEMANMKEEFEKT----KEELAKTEAKRKE-------LEEKMVTLMQEKNDL 891

Query: 610  MDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKME-----HQLEL 664
                +++ D+LA   ++  + +K  +     A+ KE+ E     E I  E      +LE 
Sbjct: 892  QLQVQAEADALADAEERCDQLIKTKIQLE--AKIKEVTERAEDEEEINAELTAKKRKLED 949

Query: 665  GNLQAKHDLET-----AMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQ 719
               + K D++      A   KEK A   K++   EE+AGL      +   + ++ +  LQ
Sbjct: 950  ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-----ETIAKLTKEKKALQ 1004

Query: 720  EAQDQRRD----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQ 775
            EA  Q  D     E +V+ L K   +   Q   +E   EQ    EKK+     L+RA+ +
Sbjct: 1005 EAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQ----EKKLC--MDLERAKRK 1058

Query: 776  GKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKR 835
             + +++  +E  +  EN                 +   ++E+  + +  +  LQ K+   
Sbjct: 1059 LEGDLKLAQESTMDTEN-----------------DKQQLNEKLKKKEFEMSNLQGKIEDE 1101

Query: 836  DKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQL 895
                  L  + + L+A++  LE + ++         K++  L  ELE +S +  +A G  
Sbjct: 1102 QALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1161

Query: 896  VLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREV--HKAEWRIKEQKLKDDIRGL 953
                +   ++E    ++R              RDL      H+A      +K  D +  L
Sbjct: 1162 SAQIEMNKKREAEFQKMR--------------RDLEESTLQHEATAAALRKKHADSVAEL 1207

Query: 954  REKLTGLDKEKSLSDQRRYSL 974
             E++  L + K   ++ +  L
Sbjct: 1208 GEQIDSLQRVKQKLEKEKSEL 1228



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 52/216 (24%), Positives = 97/216 (44%), Gaps = 12/216 (5%)

Query: 797  VEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL 856
            ++ L  S  T   E  ++ EE  +TKE +   + K  + ++++  L  +   L+ QV A 
Sbjct: 840  IKPLLKSAETEK-EMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898

Query: 857  ESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL 916
                   E++ D L+K K +LEA+++ V+ +  D       I+ EL  K+R L +    L
Sbjct: 899  ADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEE----INAELTAKKRKLEDECSEL 954

Query: 917  LEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID 976
             +           + +E H  E ++K   L +++ GL E +  L KEK    +     +D
Sbjct: 955  KKDIDDLELTLAKVEKEKHATENKVK--NLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1012

Query: 977  PSSAPE-----LLRLQHQLMSTEDALRDALDQAQQV 1007
                 E     L + + +L    D L  +L+Q +++
Sbjct: 1013 DLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKL 1048



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 45/175 (25%), Positives = 75/175 (42%), Gaps = 15/175 (8%)

Query: 349  RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVA 408
            + I+    + E LK++Q     L  ER  +  E       +   E E   LK   +Q + 
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHL--ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQ-IQ 1817

Query: 409  EAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHA 468
            + E +++     VES +K  V+    L +  R+V++L ++ EE+   K  L  Q  ++  
Sbjct: 1818 KLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEED--RKNILRLQDLVD-- 1873

Query: 469  RIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQ 523
               +L+  +   K QAE      A+ +      K R LQ E E    R +I E Q
Sbjct: 1874 ---KLQTKVKAYKRQAEE-----AEEQSNVNLAKFRKLQHELEEAKERADIAESQ 1920


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  112 bits (280), Expect = 2e-24
 Identities = 162/745 (21%), Positives = 320/745 (42%), Gaps = 144/745 (19%)

Query: 354  TTALQEALKEKQQHIE----QLLAERDLERAEVAKATSHICEVE---KEIALLKAQHEQY 406
            T A  + L+E+Q  +E    +L  E+ L    +A+ T+++ E E   K +A LK +HE  
Sbjct: 969  TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028

Query: 407  VAEAEEKLQR---ARLLVESVRK----EKVDLSNQLEEERRKVEDLQF------------ 447
            + + EE+L+R    R  +E  R+    +  DLS+Q+ E + ++ +L+             
Sbjct: 1029 ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAA 1088

Query: 448  --RVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRV 505
              RVEEE+  K     + +   ++I EL++ L     ++ER  R  A+ +   + E+   
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDL-----ESERASRNKAEKQKRDLGEELEA 1143

Query: 506  LQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRD 565
            L+ E E TL                    D   A + LR          + ++E  +L+ 
Sbjct: 1144 LKTELEDTL--------------------DSTAAQQELR---------SKREQEVNILKK 1174

Query: 566  KYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQ 625
              E+  K ++A++ ++R   +K++Q V  L ++++Q       +  N +    +L ++  
Sbjct: 1175 TLEEEAKTHEAQIQEMR---QKHSQAVEELAEQLEQTKR----VKANLEKAKQTLENERG 1227

Query: 626  KSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEH-----------------QLELGN-- 666
            +   ++K  L  G G  + +  +++A ++ ++++                  Q+EL N  
Sbjct: 1228 ELANEVKVLL-QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVT 1286

Query: 667  -LQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA------QLEVQASQHRLELQ 719
             L ++ D +++   K+  AL  +LQ+ QE L    R   +      Q+E + +  R +L+
Sbjct: 1287 GLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLE 1346

Query: 720  EAQDQRRDAE-------LRVHELEKLDVEYRGQAQAIEFLKEQI--------SLAEKKML 764
            E ++ + + E        +V +++K   +  G  +  E +K ++           E+K+ 
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA 1406

Query: 765  DYERLQRAEAQGKQEVESL-------REKLLVAENRLQAVEALCSSQHT---HMIESNDI 814
             Y++L++ + + +QE++ L       R+     E + +  + L + + T      E  D 
Sbjct: 1407 AYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDR 1466

Query: 815  SEETIRTKET-VEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKE 873
            +E   R KET    L   L +  ++   L    +  R ++  L S      K V  L K 
Sbjct: 1467 AEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKS 1526

Query: 874  KRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSRE 933
            KR LE ++E +  +  +   +L       LR E +L  ++             ERDL   
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQF----------ERDLQGR 1576

Query: 934  VHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMST 993
              ++     E+K K  +R +RE       E  L D+R+   +  ++  +L      L + 
Sbjct: 1577 DEQS-----EEKKKQLVRQVRE------MEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625

Query: 994  EDALRDALDQA-QQVEKLMEAMRSC 1017
             D+     D+A +Q+ KL   M+ C
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDC 1650



 Score =  103 bits (256), Expect = 1e-21
 Identities = 145/716 (20%), Positives = 316/716 (44%), Gaps = 77/716 (10%)

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQ 415
            A +  L E +    QL+AE+ L+  E  +A + +C   +E   L+A+      E EE   
Sbjct: 863  AAENRLTEMETLQSQLMAEK-LQLQEQLQAETELCAEAEE---LRARLTAKKQELEEICH 918

Query: 416  RARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQ 475
                 VE   +    L  + ++ ++ +++L+ ++EEE   +  L+ +     A++ +LE+
Sbjct: 919  DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE 978

Query: 476  SLLLEKAQAERLLRE--LADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPP 533
              ++ + Q  +L +E  L ++R   +AE +  L  EEE +    +++   + ++      
Sbjct: 979  EQIILEDQNCKLAKEKKLLEDR---IAEFTTNLTEEEEKSKSLAKLKNKHEAMI------ 1029

Query: 534  PDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEV- 592
                D  E LR  E+     ++ +R+           +   QA++ +L+    K  +E+ 
Sbjct: 1030 ---TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086

Query: 593  AGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGE---- 648
            A L    ++A  +NM L      +L+S  S+ Q+ LE  +A+ N     Q++++GE    
Sbjct: 1087 AALARVEEEAAQKNMALKK--IRELESQISELQEDLESERASRNKAE-KQKRDLGEELEA 1143

Query: 649  LK----------AVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELA- 697
            LK          A  + ++ + + E+  L+   + E   H  + + +R+K  +A EELA 
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE 1203

Query: 698  GLQRHWRAQLEVQASQHRLE-------------LQEAQDQRRDAELRVHELEKLDVEYRG 744
             L++  R +  ++ ++  LE             LQ   D     +    +L++L V++  
Sbjct: 1204 QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNE 1263

Query: 745  QAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQ 804
              +    L ++++   K  ++ + +    +Q   +   L +     E++LQ  + L   +
Sbjct: 1264 GERVRTELADKVT---KLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320

Query: 805  HTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 864
            +   +    +S +  + ++     +++L + ++    L  Q   L AQV+ ++ K +   
Sbjct: 1321 NRQKL---SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377

Query: 865  KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLL-------- 916
              ++   + KR+L+ +LE +S++  +       + +   R ++ L++L V L        
Sbjct: 1378 GCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSAC 1437

Query: 917  -----------LEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKS 965
                       L A   +   +    R+  +AE R KE K     R L E +    + + 
Sbjct: 1438 NLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELER 1497

Query: 966  LSDQRRYSLID-PSSAPELLRLQHQLMSTEDALRDALDQAQ-QVEKLMEAMRSCPD 1019
            L+ Q R  + D  SS  ++ +  H+L  ++ AL   +++ + Q+E+L + +++  D
Sbjct: 1498 LNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATED 1553



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 159/762 (20%), Positives = 316/762 (41%), Gaps = 137/762 (17%)

Query: 354  TTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEK 413
            +TA Q+ L+ K++    +L ++ LE     +A +H    E +I  ++ +H Q V E  E+
Sbjct: 1154 STAAQQELRSKREQEVNIL-KKTLEE----EAKTH----EAQIQEMRQKHSQAVEELAEQ 1204

Query: 414  LQRARLLVESVRKEKVDLSNQL-----------------EEERRKVE----DLQFRVEEE 452
            L++ + +  ++ K K  L N+                  E +R+KVE    +LQ +  E 
Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264

Query: 453  SITKGDLE---TQTQLEHARI-GELEQS------LLLEKAQAERLLRE----LADNRLTT 498
               + +L    T+ Q+E   + G L QS      L  + +  E  L++    L +     
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324

Query: 499  VAEKSRVLQLEEELTLRRGEIEELQQC---------LLHSGPPPPDHP---------DAA 540
            ++  +++ Q+E+E    R ++EE ++           LH+                  A 
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384

Query: 541  EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQ 600
            E+ R  ++ L    +   E     DK EK     Q E+D L    +   Q    L+ K +
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQK 1444

Query: 601  ---QATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIK 657
               Q  +E   +   +  + D   ++ ++     K T         +E  E KA +E + 
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAEARE-----KETKALSLARALEEAMEQKAELERLN 1499

Query: 658  MEHQLELGNLQA-KHDLETAMHV--KEKEALREKLQEAQEELAGLQRHWRAQLEVQASQH 714
             + + E+ +L + K D+  ++H   K K AL ++++E + +L  L+              
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED------------- 1546

Query: 715  RLELQEAQDQRRDAELRVHELE-KLDVEYRGQAQAIEFLKEQISLAEKKM---LDYERLQ 770
              ELQ  +D +   E+ +  ++ + + + +G+ +  E  K+Q+    ++M   L+ ER Q
Sbjct: 1547 --ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ 1604

Query: 771  RAEAQGKQEVESLREKLLVA------ENRLQAVEALCSSQHTHMIESNDISEETIRTKET 824
            R+ A   ++   +  K L A      +NR +A++ L   Q     +  D   E   T+ +
Sbjct: 1605 RSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ----AQMKDCMRELDDTRAS 1660

Query: 825  VEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDAL-------------- 870
             E +  +  + +K++ ++ ++   L+ +++A E   +  +++ D L              
Sbjct: 1661 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720

Query: 871  LKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPE--- 927
            L+EKRRLEA +  +  +  +  G   LI+  L +    ++++   L     H+   E   
Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780

Query: 928  RDLSREVHKAEWRIKEQ------KLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAP 981
            + L R+  + + +++E       K K  I  L  K+  L+++     + R +        
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACK----- 1835

Query: 982  ELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQT 1023
                   Q+  TE  L+D L Q     +  E  +   DKA T
Sbjct: 1836 -------QVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAST 1870



 Score = 78.2 bits (191), Expect = 4e-14
 Identities = 117/575 (20%), Positives = 247/575 (42%), Gaps = 62/575 (10%)

Query: 344  SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
            S R+  K++    L++     QQ ++ LL + D +R    ++  ++ + +K+   L A+ 
Sbjct: 1398 SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQR----QSACNLEKKQKKFDQLLAEE 1453

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDL-----QFRVEEESITKGD 458
            +   A+  E+  RA         + + L+  LEE   +  +L     QFR E E     D
Sbjct: 1454 KTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME-----D 1508

Query: 459  LETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGE 518
            L +        + ELE+S    + Q E +  +L +      A +   L+LE  L   + +
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ 1568

Query: 519  IEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVL----RDKYEKALKAY 574
             E   Q     G          +++R + R + A  E +R+   +    R K E  LK  
Sbjct: 1569 FERDLQ-----GRDEQSEEKKKQLVR-QVREMEAELEDERKQRSMAVAARKKLEMDLKDL 1622

Query: 575  QAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSL---ASDHQKSLEDL 631
            +A +D   +AN+   + +  L+ K+Q    + M  +D+ ++  + +   A +++K L+ +
Sbjct: 1623 EAHID---SANKNRDEAIKQLR-KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678

Query: 632  KATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQE 691
            +A +       Q+E+   +      + E   EL +  A    + A+ ++EK  L  ++ +
Sbjct: 1679 EAEMIQ----LQEELAAAERAKRQAQQERD-ELADEIANSSGKGALALEEKRRLEARIAQ 1733

Query: 692  AQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEK-LDVEYRGQAQAIE 750
             +EEL             +  Q   EL    D+ + A L++ ++   L++E R  AQ  E
Sbjct: 1734 LEEEL-------------EEEQGNTEL--INDRLKKANLQIDQINTDLNLE-RSHAQKNE 1777

Query: 751  FLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIE 810
              ++Q+    K++    +LQ  E   K + ++    +   E ++  +E    ++     E
Sbjct: 1778 NARQQLERQNKELK--VKLQEMEGTVKSKYKA---SITALEAKIAQLEEQLDNETK---E 1829

Query: 811  SNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDAL 870
                 ++  RT++ ++ +  +++   +       Q +    ++  L+ + +  E++    
Sbjct: 1830 RQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRA 1889

Query: 871  LKEKRRLEAELETVSRKTHDASGQLVLISQELLRK 905
               +R+L+ ELE  + +T DA  + V   +  LR+
Sbjct: 1890 NASRRKLQRELEDAT-ETADAMNREVSSLKNKLRR 1923



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 106/531 (19%), Positives = 213/531 (40%), Gaps = 71/531 (13%)

Query: 361  LKEKQQHIEQLLAE-----------RDLERAE----------VAKATSHICEVEKEIALL 399
            L++KQ+  +QLLAE           RD   AE          +A+A     E + E+  L
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERL 1498

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDL 459
              Q    + +           V  + K K  L  Q+EE + ++E+L+  ++     K  L
Sbjct: 1499 NKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL 1558

Query: 460  ETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEI 519
            E   Q   A   + E+ L     Q+E   ++L            +V ++E EL     E 
Sbjct: 1559 EVNLQ---AMKAQFERDLQGRDEQSEEKKKQLV----------RQVREMEAEL-----ED 1600

Query: 520  EELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD 579
            E  Q+ +  +     +     ++  L   + SA+K        LR K +  +K    E+D
Sbjct: 1601 ERKQRSMAVAARKKLE----MDLKDLEAHIDSANKNRDEAIKQLR-KLQAQMKDCMRELD 1655

Query: 580  KLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKS--KLDSLASDHQKSLEDLKATLNS 637
              RA+ E+   +    + K++   +E + L +   +  +    A   +  L D  A  +S
Sbjct: 1656 DTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN-SS 1714

Query: 638  GPGA-QQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEEL 696
            G GA   +E   L+A +  ++ E + E GN                E + ++L++A  ++
Sbjct: 1715 GKGALALEEKRRLEARIAQLEEELEEEQGN---------------TELINDRLKKANLQI 1759

Query: 697  AGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELE-KLDVEYRGQAQAIEFLKEQ 755
              +      +    A ++    Q+ + Q ++ ++++ E+E  +  +Y+    A+E    Q
Sbjct: 1760 DQINTDLNLE-RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQ 1818

Query: 756  ISLAEKKMLDYERLQRAEA--QGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESND 813
            +    ++ LD E  +R  A  Q ++  + L++ LL  ++  +  E               
Sbjct: 1819 L----EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874

Query: 814  ISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 864
            +  +    +E  +       K  +E+   T   + +  +VS+L++K + G+
Sbjct: 1875 LKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGD 1925



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 61/292 (20%), Positives = 126/292 (43%), Gaps = 10/292 (3%)

Query: 674  ETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVH 733
            E  + V+EK+   E      E L       + QL+ Q         EA++ R     +  
Sbjct: 852  EELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQ 911

Query: 734  ELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENR 793
            ELE++  +   + +  E   + +   +KKM   + +Q  E Q ++E ES R+KL + +  
Sbjct: 912  ELEEICHDLEARVEEEEERCQHLQAEKKKM--QQNIQELEEQLEEE-ESARQKLQLEKVT 968

Query: 794  LQAVEALCSSQHTHMIESN-DISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQ 852
             +A       +   + + N  +++E    ++ +      L + +++  +L        A 
Sbjct: 969  TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028

Query: 853  VSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNEL 912
            ++ LE + +  EK+   L K +R+LE +   +S +  +   Q+  +  +L +KE    EL
Sbjct: 1029 ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKE---EEL 1085

Query: 913  RVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEK 964
            +  L      +      L +++ + E +I E  L++D+   R      +K+K
Sbjct: 1086 QAALARVEEEAAQKNMAL-KKIRELESQISE--LQEDLESERASRNKAEKQK 1134



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 74/333 (22%), Positives = 149/333 (44%), Gaps = 34/333 (10%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L +   + +  ++    L+  LK+ + HI+     RD    ++ K  + + +  +E+   
Sbjct: 1598 LEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDT 1657

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---EEERRKVEDLQFRVEEE---S 453
            +A  E+ +A+A+E  ++    ++S+  E + L  +L   E  +R+ +  +  + +E   S
Sbjct: 1658 RASREEILAQAKENEKK----LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS 1713

Query: 454  ITKG--DLETQTQLEHARIGELEQSL------------LLEKA--QAERLLRELADNRLT 497
              KG   LE + +LE ARI +LE+ L             L+KA  Q +++  +L   R  
Sbjct: 1714 SGKGALALEEKRRLE-ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH 1772

Query: 498  TVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQ 557
                ++   QLE +    + +++E++   + S          A+I +L E+L + +KE Q
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEG-TVKSKYKASITALEAKIAQLEEQLDNETKERQ 1831

Query: 558  RESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKL 617
                 +R + EK LK    +VD  R   E+Y  +      +++Q     +   +    + 
Sbjct: 1832 AACKQVR-RTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ-LKRQLEEAEEEAQRA 1889

Query: 618  DSLASDHQKSLEDLKATLNSGPGAQQKEIGELK 650
            ++     Q+ LED   T +    A  +E+  LK
Sbjct: 1890 NASRRKLQRELEDATETAD----AMNREVSSLK 1918



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 63/309 (20%), Positives = 126/309 (40%), Gaps = 35/309 (11%)

Query: 761  KKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIR 820
            K +L   R +      ++E+  +REK L AENRL  +E L S      ++  +  +    
Sbjct: 835  KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894

Query: 821  TKETVEGLQDKLNKRDKEVTALTSQTEM-----------LRAQVSALESKCKSGEKKVDA 869
                 E L+ +L  + +E+  +    E            L+A+   ++   +  E++++ 
Sbjct: 895  LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE 954

Query: 870  LLKEKRRLEAELETVSRKTHDASGQLVLISQE--LLRKERSLNELRVLLLEAN-RHSPGP 926
                +++L+ E  T   K      + +++  +   L KE+ L E R+     N       
Sbjct: 955  EESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

Query: 927  ERDLSREVHKAEWRI--------KEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPS 978
             + L++  +K E  I        +E+K + ++   R KL G      LSDQ         
Sbjct: 1015 SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEG--DSTDLSDQ------IAE 1066

Query: 979  SAPELLRLQHQLMSTEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIH 1034
               ++  L+ QL   E+ L+ AL    ++A Q    ++ +R    +   +     +    
Sbjct: 1067 LQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERA- 1125

Query: 1035 QQDKAQKQE 1043
             ++KA+KQ+
Sbjct: 1126 SRNKAEKQK 1134


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  112 bits (280), Expect = 2e-24
 Identities = 168/728 (23%), Positives = 316/728 (43%), Gaps = 110/728 (15%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERDLERAEVAKATSHICEVEKEIAL 398
            LTE  +     I+  T  ++AL+E  QQ ++ L AE D    +V   T    ++E+++  
Sbjct: 978  LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED----KVNTLTKAKVKLEQQVDD 1033

Query: 399  LKAQHEQY------VAEAEEKLQR-ARLLVESV---RKEKVDLSNQLEEERRKVEDLQFR 448
            L+   EQ       +  A+ KL+   +L  ES+     +K  L  +L+++  ++  L  R
Sbjct: 1034 LEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNAR 1093

Query: 449  VEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQL 508
            +E+E      L+ + +   ARI ELE+ L     +AER  R             ++V +L
Sbjct: 1094 IEDEQALGSQLQKKLKELQARIEELEEEL-----EAERTAR-------------AKVEKL 1135

Query: 509  EEELTLRRGEIEELQQCLLHSGPPPP-----DHPDAAEILRLRERLLSASKEHQRESGVL 563
              +L+    E+EE+ + L  +G         +    AE  ++R  L  A+ +H+  +  L
Sbjct: 1136 RSDLSR---ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192

Query: 564  RDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD----- 618
            R K+  ++     ++D L+   +K  +E +  K ++   TS NM  +   K+ L+     
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS-NMEQIIKAKANLEKMCRT 1251

Query: 619  ---------SLASDHQKSLEDL---KATLNSGPGAQQKEIGELKAVMEGI---KMEHQLE 663
                     S A + Q+S+ DL   +A L +  G   +++ E +A++  +   K+ +  +
Sbjct: 1252 LEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQ 1311

Query: 664  LGNLQAK------------HDLETAMHVKEKEALREKLQEAQEELAGLQR---------- 701
            L +L+ +            H L++A H  + + LRE+ +E  E  A LQR          
Sbjct: 1312 LEDLKRQLEEEVKAKNALAHALQSARH--DCDLLREQYEEETEAKAELQRVLSKANSEVA 1369

Query: 702  HWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQI-SLAE 760
             WR + E  A Q   EL+EA   ++    R+ E E+       +  ++E  K ++ +  E
Sbjct: 1370 QWRTKYETDAIQRTEELEEA---KKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426

Query: 761  KKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIR 820
              M+D ER   A A   ++  +  +K+L      Q  E   S   +   E+  +S E  +
Sbjct: 1427 DLMVDVERSNAAAAALDKKQRNF-DKILAEWK--QKYEESQSELESSQKEARSLSTELFK 1483

Query: 821  TKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAE 880
             K   E   + L    +E        + L+ ++S L  +  S  K +  L K +++LEAE
Sbjct: 1484 LKNAYEESLEHLETFKRE-------NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE 1536

Query: 881  LETVSRKTHDASGQLVLISQELLRKERSLNELRV----LLLEANRHSPGPERDLSREVHK 936
               +     +A   L     ++LR +   N+++      L E +      +R+  R V  
Sbjct: 1537 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS 1596

Query: 937  AEWRI-KEQKLKDDIRGLREKLTG--LDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMST 993
             +  +  E + +++   +++K+ G   + E  LS   R +     +  ++  LQ  L  T
Sbjct: 1597 LQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMA---AEAQKQVKSLQSLLKDT 1653

Query: 994  EDALRDAL 1001
            +  L DA+
Sbjct: 1654 QIQLDDAV 1661



 Score = 97.4 bits (241), Expect = 6e-20
 Identities = 155/717 (21%), Positives = 308/717 (42%), Gaps = 91/717 (12%)

Query: 355  TALQEAL-------KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL---KAQHE 404
            T L+EAL       KE ++ +  LL E++  + +V     ++ + E+    L   K Q E
Sbjct: 857  TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916

Query: 405  QYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRV----EEESITKGDLE 460
              V E  E+L+    +   +  +K  L ++  E +R ++DL+  +    +E+  T+  ++
Sbjct: 917  AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVK 976

Query: 461  TQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIE 520
              T+ E A + E+   L  EK   +   ++  D+     AE+ +V  L +       +++
Sbjct: 977  NLTE-EMAGLDEIIAKLTKEKKALQEAHQQALDD---LQAEEDKVNTLTKAKVKLEQQVD 1032

Query: 521  ELQQCLLHSGPPPPDHPDA-----AEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQ 575
            +L+  L        D   A      ++   +E ++    + Q+    L+ K +  L A  
Sbjct: 1033 DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKK-DFELNALN 1091

Query: 576  AEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATL 635
            A ++  +A   +  +++  L+ ++++   E +      ++K++ L SD  + LE++   L
Sbjct: 1092 ARIEDEQALGSQLQKKLKELQARIEE-LEEELEAERTARAKVEKLRSDLSRELEEISERL 1150

Query: 636  NSGPGAQQKEIG-ELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQE 694
                GA   +I    K   E  KM   LE   LQ +    TA  +++K A  + + E  E
Sbjct: 1151 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE---ATAAALRKKHA--DSVAELGE 1205

Query: 695  ELAGLQRHWRAQLEVQASQHRLELQEA---------------------QDQRRDAELRVH 733
            ++  LQR  + +LE + S+ +LEL +                      +DQ  +   +  
Sbjct: 1206 QIDNLQR-VKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAE 1264

Query: 734  ELEKLDVEYRGQAQAIEFLKEQIS--LAEKKMLDYERLQRAEAQGKQEVESLREKL---L 788
            E ++   +   Q   ++    ++S  L EK+ L   +L R +    Q++E L+ +L   +
Sbjct: 1265 ETQRSVNDLTSQRAKLQTENGELSRQLDEKEAL-ISQLTRGKLTYTQQLEDLKRQLEEEV 1323

Query: 789  VAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNK-----RDKEVTALT 843
             A+N L    AL S++H   +      EET   K  ++ +  K N      R K  T   
Sbjct: 1324 KAKNAL--AHALQSARHDCDLLREQYEEET-EAKAELQRVLSKANSEVAQWRTKYETDAI 1380

Query: 844  SQTEMLRAQVSALESKCKSGEKKVDA-------LLKEKRRLEAELETVSRKTHDASGQLV 896
             +TE L      L  + +  E+ V+A       L K K RL+ E+E +      ++    
Sbjct: 1381 QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1440

Query: 897  LISQELLRKERSLNELRVLLLEAN---RHSPGPERDLSREVHKAEWRIKE-----QKLKD 948
             + ++    ++ L E +    E+      S    R LS E+ K +   +E     +  K 
Sbjct: 1441 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR 1500

Query: 949  DIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQ 1005
            + + L+E+++ L ++   S +         +  EL +++ QL + +  L+ AL++A+
Sbjct: 1501 ENKNLQEEISDLTEQLGSSGK---------TIHELEKVRKQLEAEKMELQSALEEAE 1548



 Score = 88.6 bits (218), Expect = 3e-17
 Identities = 169/828 (20%), Positives = 320/828 (38%), Gaps = 168/828 (20%)

Query: 333  RPSRSGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEV 392
            R   S  L E S R   +  G T++Q  + +K++   Q +  RDLE A +        + 
Sbjct: 1136 RSDLSRELEEISERL-EEAGGATSVQIEMNKKREAEFQKM-RRDLEEATL--------QH 1185

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVD---------------------- 430
            E   A L+ +H   VAE  E++   + + + + KEK +                      
Sbjct: 1186 EATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1245

Query: 431  ------LSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQA 484
                  L +Q+ E R K E+ Q  V + +  +  L+T+        GEL + L     + 
Sbjct: 1246 EKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTEN-------GELSRQL----DEK 1294

Query: 485  ERLLRELADNRLTTVAEKSRVL-QLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEIL 543
            E L+ +L   +LT   +   +  QLEEE+  +      LQ            + +  E  
Sbjct: 1295 EALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAK 1354

Query: 544  RLRERLLSAS----------------------KEHQRESGVLRDKYEKALKAYQAEVDKL 581
               +R+LS +                      +E +++      + E+A++A  A+   L
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414

Query: 582  RAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGA 641
                 +   E+  L   V+++ +    L D  +   D + ++ ++  E+ ++ L S    
Sbjct: 1415 EKTKHRLQNEIEDLMVDVERSNAAAAAL-DKKQRNFDKILAEWKQKYEESQSELESS--- 1470

Query: 642  QQKEIGELKAVMEGIK------MEH----QLELGNLQAK---------------HDLETA 676
             QKE   L   +  +K      +EH    + E  NLQ +               H+LE  
Sbjct: 1471 -QKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKV 1529

Query: 677  MHVKEKEALREKLQEAQEELAGLQRH-----WRAQLEVQASQHRLELQ-----EAQDQRR 726
               K+ EA + +LQ A EE      H      RAQLE    +  +E +     E  +Q +
Sbjct: 1530 R--KQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAK 1587

Query: 727  DAELRVHEL--EKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESL- 783
               LRV +     LD E R + +A+   K+      +  +      R  A+ +++V+SL 
Sbjct: 1588 RNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQ 1647

Query: 784  --------------------REKLLVAENRLQAVEALCSSQHTHMIESNDIS-----EET 818
                                +E + + E R   ++A        ++E  + S     +E 
Sbjct: 1648 SLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRA-VVEQTERSRKLAEQEL 1706

Query: 819  IRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLE 878
            I T E V+ L  +      +   + +    L+ +V     +C++ E+K    + +   + 
Sbjct: 1707 IETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMA 1766

Query: 879  AELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAE 938
             EL    +K  D S  L  + + +   E+++ +L+  L EA + +    +   +++ K E
Sbjct: 1767 EEL----KKEQDTSAHLERMKKNM---EQTIKDLQHRLDEAEQIA---LKGGKKQLQKLE 1816

Query: 939  WRIK--EQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDA 996
             R++  E +L+ + +   E + G+ K +    +  Y          LLRLQ  +   +  
Sbjct: 1817 ARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQ--TEEDRKNLLRLQDLVDKLQLK 1874

Query: 997  LRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQED 1044
            ++    QA++ E+      S   K Q           H+ D+A+++ D
Sbjct: 1875 VKAYKRQAEEAEEQANTNLSKFRKVQ-----------HELDEAEERAD 1911



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 53/211 (25%), Positives = 98/211 (46%), Gaps = 17/211 (8%)

Query: 810  ESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDA 869
            E   + EE  R KE +E  + +  + ++++ +L  +   L+ QV A +      E++ D 
Sbjct: 848  EMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQ 907

Query: 870  LLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERD 929
            L+K K +LEA+++ ++ +  D       ++ EL  K+R L +      E  R     E  
Sbjct: 908  LIKNKIQLEAKVKEMNERLEDEEE----MNAELTAKKRKLED---ECSELKRDIDDLELT 960

Query: 930  LS---REVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPE---- 982
            L+   +E H  E ++K   L +++ GL E +  L KEK    +     +D   A E    
Sbjct: 961  LAKVEKEKHATENKVK--NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVN 1018

Query: 983  -LLRLQHQLMSTEDALRDALDQAQQVEKLME 1012
             L + + +L    D L  +L+Q ++V   +E
Sbjct: 1019 TLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 39/196 (19%), Positives = 95/196 (48%), Gaps = 12/196 (6%)

Query: 831  KLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHD 890
            K  +R+KE+ ++  +   L+  +   E++ K  E+K+ +LL+EK  L+ +++       D
Sbjct: 841  KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900

Query: 891  ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQ--KLKD 948
            A  +   + +  ++ E  + E+   L +        E +++ E+   + +++++  +LK 
Sbjct: 901  AEERCDQLIKNKIQLEAKVKEMNERLED--------EEEMNAELTAKKRKLEDECSELKR 952

Query: 949  DIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPE--LLRLQHQLMSTEDALRDALDQAQQ 1006
            DI  L   L  ++KEK  ++ +  +L +  +  +  + +L  +  + ++A + ALD  Q 
Sbjct: 953  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA 1012

Query: 1007 VEKLMEAMRSCPDKAQ 1022
             E  +  +     K +
Sbjct: 1013 EEDKVNTLTKAKVKLE 1028


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  111 bits (278), Expect = 3e-24
 Identities = 165/738 (22%), Positives = 318/738 (43%), Gaps = 114/738 (15%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERD----LERAEVAKATSHICEVEK 394
            LTE  +     I+  +  ++AL+E  QQ ++ L AE D    L +A+  K    + ++E 
Sbjct: 981  LTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKT-KLEQQVDDLEG 1039

Query: 395  EIAL---LKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEE 451
             +     L+   E+   + E  L+ A+     +  +K  L  +LE++  ++ +L  ++E+
Sbjct: 1040 SLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIED 1099

Query: 452  ESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEE 511
            E   +  L+ + +   ARI EL      E+ +AER  R  A+ + + ++           
Sbjct: 1100 EQAVEIQLQKKIKELQARIEELG-----EEIEAERASRAKAEKQRSDLSR---------- 1144

Query: 512  LTLRRGEIEELQQCLLHSGPPPPDHPD-----AAEILRLRERLLSASKEHQRESGVLRDK 566
                  E+EE+ + L  +G       +      AE  +LR  L  A+ +H+     LR K
Sbjct: 1145 ------ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKK 1198

Query: 567  YEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGL-------------MDNW 613
            +  ++     ++D L+   +K  +E + LK +    +S    +             +++ 
Sbjct: 1199 HADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQ 1258

Query: 614  KSKLDSLASDHQKSLEDL---KATLNSGPGAQQKEIGELKAVMEGI------------KM 658
             S+L +   + Q+ + DL   +A L +  G   +++ E  A++  +            ++
Sbjct: 1259 VSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEEL 1318

Query: 659  EHQLELGNLQAK----HDLETAMHVKEKEALREKLQEAQEELAGLQR----------HWR 704
            +HQLE    +AK    H L+++ H  + + LRE+ +E QE  A LQR           WR
Sbjct: 1319 KHQLE-EETKAKNALAHALQSSRH--DCDLLREQYEEEQEGKAELQRALSKANSEVAQWR 1375

Query: 705  AQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQI-SLAEKKM 763
             + E  A Q   EL+EA   ++    R+ E E+       +  ++E  K+++ +  E  M
Sbjct: 1376 TKYETDAIQRTEELEEA---KKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLM 1432

Query: 764  LDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEA-LCSSQHTHMIESNDISEETIRTK 822
            LD ER   A A   ++  +  + L   + + +  +A L +SQ     ES  +S E  + K
Sbjct: 1433 LDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQK----ESRSLSTELFKVK 1488

Query: 823  ETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELE 882
               E   D+L         L  + + L+ ++S L  +   G K++  L K K+++E E  
Sbjct: 1489 NVYEESLDQLE-------TLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKC 1541

Query: 883  TVSRKTHDASGQLVLISQELLRKERSLNELRV----LLLEANRHSPGPERDLSREVHKAE 938
             +     +A   L     ++LR +  LN+++      + E +      +R+ +R V   +
Sbjct: 1542 EIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQ 1601

Query: 939  WRI-KEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLR--------LQHQ 989
              +  E + ++D   +++K+ G   E  +       L     A E LR        L+  
Sbjct: 1602 STLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRL-----AAESLRNYRNTQGILKET 1656

Query: 990  LMSTEDALRDALDQAQQV 1007
             +  +DALR   D  +Q+
Sbjct: 1657 QLHLDDALRGQEDLKEQL 1674



 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 129/599 (21%), Positives = 257/599 (42%), Gaps = 92/599 (15%)

Query: 364  KQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKL----QRARL 419
            ++Q+ E+   + +L+RA ++KA S + +   +      Q  + + EA++KL    Q A  
Sbjct: 1347 REQYEEEQEGKAELQRA-LSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1405

Query: 420  LVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLL 479
             VE+V  +   L    +  + +VEDL   VE  +     L+ + +     + E +Q    
Sbjct: 1406 HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKY-- 1463

Query: 480  EKAQAERLLRELADNRLTTVAEKSRVLQLE--EELTLRRGEIEELQQCLLHSGPPPPDHP 537
            E+ QAE    +     L+T   K + +  E  ++L   R E + LQQ             
Sbjct: 1464 EETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQ------------- 1510

Query: 538  DAAEILRLRERLLSASKE-HQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLK 596
               EI  L E++    K+ H+ E   ++ + E+     QA +++  A+ E    ++  ++
Sbjct: 1511 ---EISDLTEQIAEGGKQIHELEK--IKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQ 1565

Query: 597  DKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATL-------NSGPGAQQKEIGEL 649
             ++ Q  SE    +     ++D L  +H + +E +++TL       N     ++K  G+L
Sbjct: 1566 LELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDL 1625

Query: 650  KAV--------------------MEGIKMEHQLELGN-LQAKHDLETAMHVKEKEA--LR 686
              +                     +GI  E QL L + L+ + DL+  + + E+ A  L+
Sbjct: 1626 NEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQ 1685

Query: 687  EKLQEAQEELAGLQRHWR-AQLEVQASQHRLELQEAQDQ-----RRDAELRVHELE-KLD 739
             +++E    L   +R  + A+ E+  +  R++L   Q+      ++  E  V +L+ +++
Sbjct: 1686 AEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVE 1745

Query: 740  VEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEA 799
               +    A E  K+ I+ A     + ++ Q   A  ++  ++L + +   ++RL   E 
Sbjct: 1746 EVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1805

Query: 800  LCSSQHTHMIES---------NDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTE--- 847
            L        I+           ++  E  R  E V+GL+    K ++ V  LT QTE   
Sbjct: 1806 LALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLR----KHERRVKELTYQTEEDR 1861

Query: 848  -----------MLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQL 895
                        L+A+V + + + +  E++ +A L + R+L+ ELE    +   A  Q+
Sbjct: 1862 KNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQV 1920



 Score = 84.3 bits (207), Expect = 5e-16
 Identities = 129/587 (21%), Positives = 247/587 (42%), Gaps = 53/587 (9%)

Query: 462  QTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRV-LQLEEELTLRRGEIE 520
            +T+ E A + E  Q    E A++E   +EL +  +T + EK+ + LQ++ E        E
Sbjct: 847  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906

Query: 521  ELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDK 580
              +Q + +           A+I  + ER     +E   E    + K E      + ++D 
Sbjct: 907  RCEQLIKNK------IQLEAKIKEVTER-AEEEEEINAELTAKKRKLEDECSELKKDIDD 959

Query: 581  LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD----SLASDHQKSLEDLKA--- 633
            L     K  +E    ++KV+  T E  GL D   +KL     +L   HQ++L+DL+A   
Sbjct: 960  LELTLAKVEKEKHATENKVKNLTEEMAGL-DETIAKLSKEKKALQETHQQTLDDLQAEED 1018

Query: 634  ---TLNSGPGAQQKEIGELKAVME-GIKMEHQLELGNLQAKHDLETAMH-----VKEKEA 684
                L       ++++ +L+  +E   K+   LE    + + DL+ A         +K+ 
Sbjct: 1019 KVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ 1078

Query: 685  LREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHEL-EKLDVEYR 743
            L EKL++ + E++ L       +     +  +E+Q  Q + ++ + R+ EL E+++ E  
Sbjct: 1079 LDEKLEKKEFEISNL-------ISKIEDEQAVEIQ-LQKKIKELQARIEELGEEIEAERA 1130

Query: 744  GQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSS 803
             +A+A    K++  L+ +     ERL+ A      +VE L +K      +L+      + 
Sbjct: 1131 SRAKA---EKQRSDLSRELEEISERLEEAGGATSAQVE-LNKKREAEFQKLRRDLEEATL 1186

Query: 804  QHTHMIES--NDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCK 861
            QH  M+ +     ++      E ++ LQ    K +KE + L  +T+ L +   A+     
Sbjct: 1187 QHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKG 1246

Query: 862  SGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANR 921
            + EK   +L  +   L+ + E   R  +D + Q   +  E     R L+E   L+ + +R
Sbjct: 1247 NLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSR 1306

Query: 922  HSPGPERDLSREVHKAEWRIKE--------QKLKDDIRGLREKLTGLDKEKSLSDQRRYS 973
                  + +    H+ E   K         Q  + D   LRE+    ++E     QR  S
Sbjct: 1307 SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEE-EQEGKAELQRALS 1365

Query: 974  LIDPSSAPELLRLQHQLMSTEDALRDA----LDQAQQVEKLMEAMRS 1016
              +   A    + +   +   + L +A      + Q+ E+ +EA+ +
Sbjct: 1366 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNA 1412



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 68/305 (22%), Positives = 134/305 (43%), Gaps = 19/305 (6%)

Query: 673  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV-------QASQHRLELQEAQDQR 725
            L++A   KE   ++E+ Q+ ++ELA  +   R +LE        + +  +L++Q   D  
Sbjct: 843  LKSAETEKEMATMKEEFQKTKDELAKSEAK-RKELEEKMVTLLKEKNDLQLQVQSEADSL 901

Query: 726  RDAELRVHELEKLDVEYRGQAQAI-EFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLR 784
             DAE R  +L K  ++   + + + E  +E+  +  +      +L+   ++ K++++ L 
Sbjct: 902  ADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLE 961

Query: 785  EKLLVAENRLQAVEALCSSQHTHMIESND----ISEETIRTKETVEGLQDKLNKRDKEVT 840
              L   E    A E    +    M   ++    +S+E    +ET +   D L   + +V 
Sbjct: 962  LTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVN 1021

Query: 841  ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 900
             LT     L  QV  LE   +  +K    L + KR+LE +L+     T D       + +
Sbjct: 1022 ILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDE 1081

Query: 901  ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGL 960
            +L +KE  ++     L+         E  L +++ + + RI+E  L ++I   R      
Sbjct: 1082 KLEKKEFEISN----LISKIEDEQAVEIQLQKKIKELQARIEE--LGEEIEAERASRAKA 1135

Query: 961  DKEKS 965
            +K++S
Sbjct: 1136 EKQRS 1140



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 126/568 (22%), Positives = 241/568 (42%), Gaps = 76/568 (13%)

Query: 481  KAQAERLLRELADNRLTTVAEKSR------VLQLEEELTLRRGEIEELQQCLLHSGPPPP 534
            KA    LL E+ D +L  +  +++      ++++E +  L+R E     Q  + +     
Sbjct: 769  KAGLLGLLEEMRDEKLAQIITRTQAVCRGFLMRVEYQKMLQRREALFCIQYNVRAFMNVK 828

Query: 535  DHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAG 594
              P      +++  L SA  E ++E   ++++++K         D+L  +  K  +    
Sbjct: 829  HWPWMKLFFKIKPLLKSA--ETEKEMATMKEEFQKTK-------DELAKSEAKRKE---- 875

Query: 595  LKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ-----KEIGEL 649
            L++K+     E   L    +S+ DSLA   ++  + +K  +      ++     +E  E+
Sbjct: 876  LEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEI 935

Query: 650  KAVMEGIKMEHQLELGNLQAKHD---LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQ 706
             A +   K + + E   L+   D   L  A   KEK A   K++   EE+AGL      +
Sbjct: 936  NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-----E 990

Query: 707  LEVQASQHRLELQEAQDQRRD----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKK 762
               + S+ +  LQE   Q  D     E +V+ L K   +   Q   +E   EQ    EKK
Sbjct: 991  TIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQ----EKK 1046

Query: 763  M-LDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT 821
            + +D   L+RA+ + + +++  +E  +  EN  Q ++     +   +  SN IS+  I  
Sbjct: 1047 LRMD---LERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEI--SNLISK--IED 1099

Query: 822  KETVE-GLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAE 880
            ++ VE  LQ K+ +    +  L  + E  RA  +  E              K++  L  E
Sbjct: 1100 EQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE--------------KQRSDLSRE 1145

Query: 881  LETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWR 940
            LE +S +  +A G      +   ++E    +LR  L EA          L ++   +   
Sbjct: 1146 LEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAE 1205

Query: 941  IKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL-----RLQHQLMSTED 995
            + EQ   D+++ +++K   L+KEKS   + +    D SS  E +      L+    S ED
Sbjct: 1206 LGEQ--IDNLQRVKQK---LEKEKS---ELKMETDDLSSNAEAISKAKGNLEKMCRSLED 1257

Query: 996  ALRDALDQAQQVEKLMEAMRSCPDKAQT 1023
             + +   + ++ ++L+  + +   + QT
Sbjct: 1258 QVSELKTKEEEQQRLINDLTAQRARLQT 1285


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  110 bits (275), Expect = 7e-24
 Identities = 191/834 (22%), Positives = 339/834 (40%), Gaps = 129/834 (15%)

Query: 306  MGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQ 365
            M  S L +   SSS  S+       G    +  L+ E  S  + KI+ +T  QE  KE Q
Sbjct: 1555 MDRSLLENQSLSSSCESLKLALE--GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQ 1612

Query: 366  QHIEQLLAERDLERAEVAKATSHICEVEKE-----------IALLKAQHEQYVAEAEEKL 414
            +  E LL   +    E A+   H+ E  ++               K + E+ + EAE+++
Sbjct: 1613 KEYEILLQSYENVSNE-AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEM 1671

Query: 415  QRARLLVESVRKEKVDLSNQLEEERRKV------------EDLQFRVEEESITKGDLETQ 462
            +  +  +    K K     +LEEE  ++            E ++  +   +  K +LE +
Sbjct: 1672 EEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELE-R 1730

Query: 463  TQLEHARIGELEQSLLLEKAQAERLLRELAD----------NRLTTVAEKSRVLQLEEEL 512
             ++E+  + +  QSL+ EK      +++L            N   T    ++    EE  
Sbjct: 1731 VKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT 1790

Query: 513  TLRRGEIEELQQCLLHSGPPPPDHPDAA----------------------EILRLRERLL 550
                GE EE     + + P   +   +A                      +I +L+ER+ 
Sbjct: 1791 QSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA 1850

Query: 551  SASKEHQR----------ESGVLRDKY---EKALKAYQAEVDKLRAANEKYAQEVAGLKD 597
               +E Q+          E   L  +    +  LK  Q EV K+   N++  +E++ +  
Sbjct: 1851 GLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTK 1910

Query: 598  KVQQATSENMGLMDNWKSKLDSLASDHQKSLEDL------KATLNSGPGAQQKEIGELKA 651
              + A  E   L +   ++L  L        +D+         L S     +K + EL+ 
Sbjct: 1911 LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970

Query: 652  -----VMEGIKMEHQLELGNLQ----AKHDLETAMHVKEKEALREKLQEAQEELAGLQRH 702
                 V E  K+E ++    L+    A+ +     H KE   L+E L+E Q+E+  LQ+ 
Sbjct: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE---LQELLKEKQQEVKQLQKD 2027

Query: 703  W-RAQLEVQASQHRLELQE--AQDQRRDAELRVHELEKLDVEYRGQAQAI-----EFLKE 754
              R Q ++ A +  ++  E    + ++D E+    L +  VE+R +AQA        L +
Sbjct: 2028 CIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQA-VEHRKKAQAELASFKVLLDD 2086

Query: 755  QISLAEKKMLDYERLQRAEAQGKQEVES-LREKLLVAENRLQAVEALCSSQHTHMIESND 813
              S A + + D  +L++     K+ V+S +++K    E RL+  E     +  +M E  D
Sbjct: 2087 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLD 2146

Query: 814  -ISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLK 872
             +  E +  +ET+  +Q  LNK+DKEV  L    +    Q++A      S +   D ++ 
Sbjct: 2147 ALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID 2206

Query: 873  EKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSR 932
            E ++ E       RK  DA   +    +E+  KE + + L+  L + + H    + ++SR
Sbjct: 2207 EAKKWE-------RKFSDA---IQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISR 2256

Query: 933  EVH-KAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLM 991
              H K  W  K Q      + + + L G +KE  LS       +  SS  EL +L+ +L 
Sbjct: 2257 LEHDKQIWESKAQTEVQLQQKVCDTLQGENKE-LLSQLEETRHLYHSSQNELAKLESELK 2315

Query: 992  STEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDK 1045
            S +D L D          L  ++  C ++       G+  GI +Q +A  Q  K
Sbjct: 2316 SLKDQLTD----------LSNSLEKCKEQ------KGNLEGIIRQQEADIQNSK 2353



 Score =  102 bits (254), Expect = 2e-21
 Identities = 164/825 (19%), Positives = 343/825 (41%), Gaps = 111/825 (13%)

Query: 308  VSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQH 367
            +S  T    S S+ S  S   +V    S    +     +  +       L+E  ++ ++ 
Sbjct: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEF 1862

Query: 368  IEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKE 427
             + L  E++   ++++     +  +++E+  +   ++Q     +E+L R   L E+  +E
Sbjct: 1863 SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQI----QEELSRVTKLKETAEEE 1918

Query: 428  KVDLS----NQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELE---QSLLLE 480
            K DL     NQL E    + +    V +  I    LE++ +     + ELE   Q L+ E
Sbjct: 1919 KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKE 1978

Query: 481  KAQAERLLR----ELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQ-CLLHSGPPPPD 535
            K + E  +R    E           KS   +L+E L  ++ E+++LQ+ C+ +       
Sbjct: 1979 KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQ------ 2032

Query: 536  HPDAAEILRLRERLLSASKEHQRESGVLRDKYEKAL---KAYQAEVDKLRAANEKYAQEV 592
                + + R  + L     E Q++  + ++   +A+   K  QAE+   +   +    E 
Sbjct: 2033 -EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEA 2091

Query: 593  AGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAV 652
            A       +  ++N+ L    +S  +S+ S  ++  EDL+  L     A++K + E K +
Sbjct: 2092 A-------RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ---AEEKHLKEKKNM 2141

Query: 653  MEGIKMEHQLELGNLQAKHDLETAMHVKEKEA--LREKLQEAQEELAGLQRH-------- 702
             E +    + ++   +   +++  ++ K+KE   L+E L     +LA   +         
Sbjct: 2142 QEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDR 2201

Query: 703  ---------WRAQLE--VQASQHRLELQE-----AQDQRRDAELRVHELE---------- 736
                     W  +    +Q+ +  + L+E      +DQ R   + + EL+          
Sbjct: 2202 DRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261

Query: 737  -----KLDVEYRGQAQAIEFL----KEQISLAEKKMLDYERLQRAEAQGKQEVESLREKL 787
                 K   E + Q +  + L    KE +S  E+    Y   Q   A+ + E++SL+++L
Sbjct: 2262 QIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL 2321

Query: 788  LVAENRLQA-------VEALCSSQHTHMIESNDISEETIRT-----KETVEGLQDKLNKR 835
                N L+        +E +   Q    I+++  S E + T     +E    L +++N +
Sbjct: 2322 TDLSNSLEKCKEQKGNLEGIIRQQEAD-IQNSKFSYEQLETDLQASRELTSRLHEEINMK 2380

Query: 836  DKEVTALTS-QTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQ 894
            ++++ +L S + E ++  ++ L  +     K+++ LL ++      LE  ++K  D + Q
Sbjct: 2381 EQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQ 2440

Query: 895  LV----LISQELLRKERSLNEL--RVLLLEANR------HSPGPERDLSREVHK----AE 938
            L+     I +E ++++  L+     +  L+ +R      +    ER LS  + K     E
Sbjct: 2441 LMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQE 2500

Query: 939  WRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALR 998
               +  KLK++IRGLR  +  L+ E +  D       +  +    ++   Q    E  L+
Sbjct: 2501 AAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ 2560

Query: 999  DALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQE 1043
               +   +  KL E ++   +  + +  S +A    +QD +++ E
Sbjct: 2561 QNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIE 2605



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 156/769 (20%), Positives = 314/769 (40%), Gaps = 103/769 (13%)

Query: 339  LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAE-RDLERAEVAKATSHICEVEKEIA 397
            LL + + +  RK+      ++ L ++   +E+ LA  +D  + E+  + +   EVE++  
Sbjct: 983  LLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEED-- 1040

Query: 398  LLKAQHEQYVAEAEEKLQRARL-LVESVRKEKVDLSN---QLEEERRKVEDLQFRVEEES 453
              K   E        K Q   + L +++ +++V+L +    LEE+    E  Q  V++ +
Sbjct: 1041 --KENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMN 1098

Query: 454  ITKGDLETQTQLEHARIGELE---QSLLLEKAQA-----------------------ERL 487
             T  D   Q  L  A I E +   Q L+     A                       E  
Sbjct: 1099 QTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHW 1158

Query: 488  LRELADNRLTTVAEKSRVLQ-LEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLR 546
              EL +  L    EK ++ + L+E LT R+  +++ Q+   H         D  +  RL+
Sbjct: 1159 KPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKD--DYNRLQ 1216

Query: 547  ERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSEN 606
            E+    SKE++     LR    +  ++   ++       ++      GL++ + +AT ++
Sbjct: 1217 EQFDEQSKENENIGDQLRQLQIQVRESIDGKLPS--TDQQESCSSTPGLEEPLFKATEQH 1274

Query: 607  -------MGLMDNWKSKL-DSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVM----- 653
                     L  +W S   D+ A     S+  +KA L     A++ E+ ELK        
Sbjct: 1275 HTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIE-AEKVEL-ELKVSSTTSEL 1332

Query: 654  -----EGIKMEHQLELGNLQAKHDLETAMHVKE--KEALREKLQEAQEELAGLQRHWRAQ 706
                 E  +++ Q+    L+ +  L+T  H  E   E+L++KL+ +Q ++AGL+     Q
Sbjct: 1333 TKKSEEVFQLQEQINKQGLEIE-SLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQ 1391

Query: 707  LEVQASQHRLELQEAQDQRRDAELRVHE--LEKLDVEYRGQAQAIEFLKEQISLAEKKML 764
             ++   Q  +  +E        +L   E  L K+  E   Q   I+ L  Q+ +  K+  
Sbjct: 1392 PKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHD 1451

Query: 765  D-YERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKE 823
            +  ++LQ    + KQ+ E + E+    +   + ++A   S+   + E+  + EE    + 
Sbjct: 1452 ERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARG 1511

Query: 824  TVEGLQDKLNKRDKEVTALTSQ-------------------TEMLRAQVS--ALESKCKS 862
            T+E L   L   + +V+A   +                   TEM R+ +   +L S C+S
Sbjct: 1512 TIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCES 1571

Query: 863  GEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRH 922
             +  ++ L ++K +L  E+E++           +  S E   K + L +   +LL++  +
Sbjct: 1572 LKLALEGLTEDKEKLVKEIESL-------KSSKIAESTEWQEKHKELQKEYEILLQSYEN 1624

Query: 923  SPGPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLID------ 976
                   +   V     R ++Q+L   +R         +K+   ++Q    + +      
Sbjct: 1625 VSNEAERIQHVVEAV--RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFA 1682

Query: 977  PSSAPELLRLQHQLMSTEDALRDALDQAQQ-VEKLMEAMRSCPDKAQTI 1024
             S   ++L L+ +       +  A D A++ +E L+ +  S  ++ + +
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERV 1731



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 136/715 (19%), Positives = 299/715 (41%), Gaps = 75/715 (10%)

Query: 317  SSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKEKQQHI---EQLLA 373
            S   + + S+ S +  + S    + E + R     S    L +AL +K+  I   +QLL 
Sbjct: 827  SEQSTLIRSLQSQLQNKESE---VLEGAERVRHISSKVEELSQALSQKELEITKMDQLLL 883

Query: 374  ERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSN 433
            E+   + +V      I E ++++  +     + + +  E+     + ++++ KE+++L +
Sbjct: 884  EK---KRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTL-KEQLNLLS 939

Query: 434  QLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELAD 493
            + EE ++  E ++   E  S  K + +  +        EL+    L K + E+  R+L  
Sbjct: 940  RAEEAKK--EQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQA 997

Query: 494  NRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSAS 553
              +       RV +LEEEL   + E ++           P    +  E+   +E    + 
Sbjct: 998  ALINRKELLQRVSRLEEELANLKDESKK---------EIPLSETERGEVEEDKENKEYSE 1048

Query: 554  KEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNW 613
            K    +   +    ++ +   + E+  +R    K  +E    +++ Q    +    + + 
Sbjct: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIR----KDLEEKLAAEEQFQALVKQMNQTLQDK 1104

Query: 614  KSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDL 673
             +++D L ++  ++   ++  + S   A   +   +  V E + +       +   K +L
Sbjct: 1105 TNQIDLLQAEISENQAIIQKLITSNTDASDGD--SVALVKETVVISPPCTGSSEHWKPEL 1162

Query: 674  ETAMHV--KEKEALREKLQEAQEELAGL-------QRHWRAQLEVQASQHRLELQEAQDQ 724
            E  +    KEKE L++KLQEA      +       +RH R +L+ Q   +    ++  +Q
Sbjct: 1163 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1222

Query: 725  RRDAELRVHELEKLDVEYRGQAQA-IEFLKEQISLAEKKMLDYERLQRAEAQGKQEV--- 780
             ++ E    +L +L ++ R      +    +Q S +    L+    +  E    Q V   
Sbjct: 1223 SKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLES 1282

Query: 781  -------------ESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEG 827
                          +L+    VA+ + Q  E         +  S+  SE T +++E  + 
Sbjct: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQ- 1341

Query: 828  LQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRK 887
            LQ+++NK+  E+ +L + +        +L+ K +S + ++ A L+  R L+ +L+ + + 
Sbjct: 1342 LQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQI-AGLEHLRELQPKLDELQKL 1400

Query: 888  THDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVH-KAEWRIKEQKL 946
                   +  +S +L  KE +L +++  ++E        + DL + +H + E + KE   
Sbjct: 1401 ISKKEEDVSYLSGQLSEKEAALTKIQTEIIE--------QEDLIKALHTQLEMQAKEHD- 1451

Query: 947  KDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL--RLQHQLMSTEDALRD 999
                    E++  L  E     Q+   + + S A + +  +LQ  L+S ++AL++
Sbjct: 1452 --------ERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKE 1498



 Score = 77.0 bits (188), Expect = 8e-14
 Identities = 170/753 (22%), Positives = 309/753 (41%), Gaps = 112/753 (14%)

Query: 357  LQEALKEKQQHIEQL-LAERDLE----------RAEVAKATSHICEVEK----------- 394
            LQE +    +  EQ   A+ +LE          +AE+ + TSHI  ++K           
Sbjct: 338  LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDA 397

Query: 395  ----EIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLE-EERRKVEDLQFRV 449
                   LL+ ++EQ V  A+  +Q+    ++   KE     N+L  ++        F  
Sbjct: 398  LKDQNSKLLQDKNEQAVQSAQT-IQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPD 456

Query: 450  EEESITKGDLETQTQLEHARIGELEQ---SLLLEKAQAERLL--RELADNRLTTVAEKSR 504
                 T+   E        R+ ELE    +LLL   + E L    E   +++T +  ++R
Sbjct: 457  VYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNR 516

Query: 505  VLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRER-----LLSASKEHQRE 559
              + + E++    EI  +      S        D  E    ++      LL   KE Q E
Sbjct: 517  TGEADREVS----EISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEE 572

Query: 560  SGVLRDKYE-KALKAYQAEVDKLRAANEKYAQEVAGLKDKV-QQATSENMGLMDNWKSKL 617
               L+ + + K  +    EV   +   +   + +A +K KV  + T ++  LM N +S L
Sbjct: 573  IAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSL 632

Query: 618  DSL-----ASDHQK------SLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGN 666
             ++     +++HQ       SL D    L S    +Q     L AV + I   HQ EL  
Sbjct: 633  PAVEKEQASTEHQSRTSEEISLNDAGVELKS---TKQDGDKSLSAVPD-IGQCHQDELER 688

Query: 667  LQAKH-DLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQR 725
            L+++  +LE   H K +E   + L E  +E++ L +    + +  A  +        ++R
Sbjct: 689  LKSQILELELNFH-KAQEIYEKNLDEKAKEISNLNQLIE-EFKKNADNNSSAFTALSEER 746

Query: 726  RDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAE---KKMLDYERLQRAEAQGKQEVES 782
                 +V EL  +  E R Q + +E     ++LAE   ++ LDYE     +    +++ S
Sbjct: 747  DQLLSQVKELSMV-TELRAQVKQLE-----MNLAEAERQRRLDYESQTAHDNLLTEQIHS 800

Query: 783  LREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTAL 842
            L    + A+++   +E L +       E +D+  +       +  LQ +L  ++ EV   
Sbjct: 801  LS---IEAKSKDVKIEVLQN-------ELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850

Query: 843  TSQTEMLRAQVSALESKCKSGE---KKVDALLKEKRRLEAELETVSRKTHDASGQLVLIS 899
              +   + ++V  L       E    K+D LL EK+R   ++ET+ +   +   Q+  IS
Sbjct: 851  AERVRHISSKVEELSQALSQKELEITKMDQLLLEKKR---DVETLQQTIEEKDQQVTEIS 907

Query: 900  QELLRKERSLNELRVLLLEANRHSPGPERDLSRE----VHKAEWRIKEQKLKDD--IRGL 953
              +  K   LNE         + S G E    +E    + +AE   KEQ  +D+    GL
Sbjct: 908  FSMTEKMVQLNE--------EKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGL 959

Query: 954  REKLTGLDKEKSLSD---QRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKL 1010
            ++    +     +S    Q  + L+   +     +LQ  L++ ++ L       Q+V +L
Sbjct: 960  KQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELL-------QRVSRL 1012

Query: 1011 MEAMRSCPDKA-QTIGNSGSANGIHQQDKAQKQ 1042
             E + +  D++ + I  S +  G  ++DK  K+
Sbjct: 1013 EEELANLKDESKKEIPLSETERGEVEEDKENKE 1045



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 149/711 (20%), Positives = 282/711 (39%), Gaps = 107/711 (15%)

Query: 363  EKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVE 422
            EK Q I++  AE +  + E+    SH+ ++  E A L A+  QY     E L +   + +
Sbjct: 2493 EKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQY----REDLNQVITIKD 2548

Query: 423  SVRKEKVDLSNQLEEE-RRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEK 481
            S +K+ +++  Q  +E   K   L+ +++E      DL            +L + +   K
Sbjct: 2549 SQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLK 2608

Query: 482  AQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAE 541
                +L R+     +T + E+  +     +L ++  E+  L      S            
Sbjct: 2609 VSISQLTRQ-----VTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS---------QKR 2654

Query: 542  ILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANE-------KYAQEVAG 594
            I  L E L+   KE  ++ G + DK +K LK    +   +R   E       + A+++  
Sbjct: 2655 IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVE 2714

Query: 595  LKDKVQQATSENMGLMDNWKSKLDSLAS-----DH-QKSLEDLKATLNSG--PGAQQKEI 646
            ++ K+   T EN GL    +S   S++S     DH  + L++LK   ++     AQ KE 
Sbjct: 2715 MEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ 2774

Query: 647  GELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQ 706
            G L    + +  E    + + +          +   E L ++L    E+L     H  +Q
Sbjct: 2775 GLLNRERDALLSETAFSMNSTEEN-------SLSHLEKLNQQLLSKDEQLL----HLSSQ 2823

Query: 707  LEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDY 766
            LE   +Q +   +     + + +   +ELEK             F K +           
Sbjct: 2824 LEDSYNQVQSFSKAMASLQNERDHLWNELEK-------------FRKSE----------- 2859

Query: 767  ERLQRAEAQ---GKQEVESLREKLLVAEN-RLQAVEALCSSQHTHMIESNDISEETIRTK 822
            E  QR+ AQ      EV+SL++ +   +N R + ++ L + Q  ++  + +I+E      
Sbjct: 2860 EGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITE------ 2913

Query: 823  ETVEGLQDKLNK-RDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAEL 881
              +  L+ +L + +DK       Q E+ +  +S      +   +K    + E+R  E  L
Sbjct: 2914 --LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYL 2971

Query: 882  ETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHK---AE 938
              +S K    S       Q L+R+ RS +     L    +    PE   S +  +    E
Sbjct: 2972 MAISDKDQQLSH-----LQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYE 3026

Query: 939  WRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALR 998
              +   +L D ++ + +K   + +  S   Q    L++  +      L  QL  T  +LR
Sbjct: 3027 TELLRTQLNDSLKEIHQKELRIQQLNSNFSQ----LLEEKNT-----LSIQLCDTSQSLR 3077

Query: 999  -------DALDQAQQVEKLMEAMRSCPDKAQTI-GNSGSANGIHQQDKAQK 1041
                   D L+    +EK ++ +++ P       G     NG+H++   ++
Sbjct: 3078 ENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEE 3128



 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 164/750 (21%), Positives = 295/750 (39%), Gaps = 126/750 (16%)

Query: 359  EALKEKQQHIEQLLA--ERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQR 416
            E +K K Q  E+L++  +  L +A+  +      E+E+ + +     +Q + E EE +  
Sbjct: 147  EKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM-----KQQLQEKEEFIST 201

Query: 417  ARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEES----ITKGDLETQTQLE----HA 468
             +  +   + E+   + Q+  E+    + Q R+ E+     +T+ D+ET+ Q +      
Sbjct: 202  LQAQLSQTQAEQA--AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQR 259

Query: 469  RIGELEQSLLLEKAQAERLLRELA-----------------------DNRLTTVAEKSRV 505
            ++ E E+SL+      + L +EL                         N + T  E+S++
Sbjct: 260  KLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKI 319

Query: 506  L--QLEEELTLRRGEIEELQ----------------QCLLHSGPPPPDHPDAAEILRLRE 547
            L  ++E E+  R+     LQ                Q  L S     +    AE+     
Sbjct: 320  LLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTS 379

Query: 548  RLLSASK---EHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATS 604
             +LS  K   E Q     L+D+  K L+      DK   A +  AQ +  L+D++QQ + 
Sbjct: 380  HILSLQKTGQELQSACDALKDQNSKLLQ------DKNEQAVQS-AQTIQQLEDQLQQKSK 432

Query: 605  ENMGLMDNWKSKLDSLASDHQKSLEDL-----KATLNSGPGAQQKEIGELKAVMEGIKME 659
            E    ++    +    AS  Q S  D+     +A       + QK + EL+   +G  + 
Sbjct: 433  EISQFLNRLPLQQHETAS--QTSFPDVYNEGTQAVTEENIASLQKRVVELEN-EKGALLL 489

Query: 660  HQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQ 719
              +EL  L+A++         EK + +  L EAQ       R       V  +  R    
Sbjct: 490  SSIELEELKAEN---------EKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540

Query: 720  E--AQDQRRDAELRVH-ELEKLDVEYRGQAQAIEFLKEQI-----SLAEKKMLDYERLQR 771
            E   QD   +   + H EL  L +E +   + I FLK Q+       A+ ++LD + +++
Sbjct: 541  EESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ 600

Query: 772  AEAQG------KQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETV 825
             E +G      K  +E   +   +  N   ++ A+   Q +   E    + E I   +  
Sbjct: 601  MEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAS--TEHQSRTSEEISLNDAG 658

Query: 826  EGLQDKLNKRDKEVTAL-------TSQTEMLRAQVSALESKCKSG----EKKVDALLKEK 874
              L+      DK ++A+         + E L++Q+  LE          EK +D   KE 
Sbjct: 659  VELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEI 718

Query: 875  RRLEAELETVSRKTHDASGQLVLISQE---LLRKERSLN---ELR--VLLLEANRHSPGP 926
              L   +E   +   + S     +S+E   LL + + L+   ELR  V  LE N      
Sbjct: 719  SNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAER 778

Query: 927  ERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLD-KEKSLSDQRRYSLIDPSSAPELLR 985
            +R L  E   A     +  L + I  L  +    D K + L ++     +  S    L+R
Sbjct: 779  QRRLDYESQTAH----DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIR 834

Query: 986  -LQHQLMSTEDALRDALDQAQQVEKLMEAM 1014
             LQ QL + E  + +  ++ + +   +E +
Sbjct: 835  SLQSQLQNKESEVLEGAERVRHISSKVEEL 864



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 129/614 (21%), Positives = 236/614 (38%), Gaps = 75/614 (12%)

Query: 355  TALQEALKEKQQHIEQLLAERDLERAEVAKATSH--ICEVEKEIALLKAQHEQYVAEAEE 412
            TALQE       H +  + E ++ R     ++S   I E+E+E+  ++ +  + V E E+
Sbjct: 2619 TALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED 2678

Query: 413  KLQRARLLVESVRKEKVDLSNQLEEERRKVEDL-QFRVEEES----ITKGDLETQTQLEH 467
            KL++    ++ +  +   + N+ E    +V +L +  VE E     +TK +     Q++ 
Sbjct: 2679 KLKKE---LKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQS 2735

Query: 468  ARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLL 527
               G    SL   +  A   L EL      ++ E   + QL+E+  L R     L +   
Sbjct: 2736 --FGRSMSSLQNSRDHANEELDELKRKYDASLKE---LAQLKEQGLLNRERDALLSETAF 2790

Query: 528  HSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYE------KALKAYQAEVDKL 581
                   +    + + +L ++LLS  ++    S  L D Y       KA+ + Q E D L
Sbjct: 2791 SMNST--EENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL 2848

Query: 582  RAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGA 641
                EK+ +   G K +     S +   + + K  + SL +D  + L++LK         
Sbjct: 2849 WNELEKFRKSEEG-KQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQI 2907

Query: 642  QQK--EIGELKAVMEGIK--------MEHQLELGNLQAKHDLETAMHVKEKEALREKLQE 691
             Q+  E+  LKA ++  +        M+ +L   NL  +H+L      K    + E+  +
Sbjct: 2908 NQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMK 2967

Query: 692  AQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEF 751
             Q  +A              S    +L   Q+  R+      + + L V+Y+ QA     
Sbjct: 2968 EQYLMA-------------ISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASP--- 3011

Query: 752  LKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIES 811
             +   S    + L YE  +    Q    ++ + +K L  +        L   ++T  I+ 
Sbjct: 3012 -ETSASPDGSQNLVYET-ELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQL 3069

Query: 812  NDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALL 871
             D S+     ++    L +     +K+V  L +    +     A + K     K     L
Sbjct: 3070 CDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEEL 3129

Query: 872  KEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLS 931
            +E ++  +E +                 Q+L    + +NELR LL E        E  LS
Sbjct: 3130 REPQQSFSEAQ-----------------QQLCNTRQEVNELRKLLEEERDQRVAAENALS 3172

Query: 932  ------REVHKAEW 939
                  R +  +EW
Sbjct: 3173 VAEEQIRRLEHSEW 3186



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 106/523 (20%), Positives = 216/523 (41%), Gaps = 86/523 (16%)

Query: 588  YAQE-VAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEI 646
            YA++ V  LKD ++Q   +     +  + +  +  +  +K     KA L S      K I
Sbjct: 56   YAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTS----LNKYI 111

Query: 647  GELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH---- 702
             E+KA   G  +  + +     +KHD  +     E E ++ KLQE +E ++ LQ      
Sbjct: 112  EEMKA-QGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQA 170

Query: 703  -------------------------------WRAQL-EVQASQHRLELQEAQDQRRDAEL 730
                                            +AQL + QA Q   ++   +D R + ++
Sbjct: 171  QAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQV 230

Query: 731  RVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVA 790
            R+HE E L +    QA     +++++ + ++K+ ++E      A   Q V+ L+++L  A
Sbjct: 231  RLHEDELLQLV--TQADVETEMQQKLRVLQRKLEEHEESLVGRA---QVVDLLQQELTAA 285

Query: 791  ENRLQAV-EALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKR-------DKEVTAL 842
            E R Q + + L   +  H    N +  E   +K  +E ++ ++ +R        +E+  L
Sbjct: 286  EQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHL 345

Query: 843  TSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQEL 902
              Q E      + LES+  + E+K  A ++EK      L+   ++   A   L   + +L
Sbjct: 346  LEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL 405

Query: 903  LRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQK----------------- 945
            L+ +   NE  V   +  +      +  S+E+ +   R+  Q+                 
Sbjct: 406  LQDK---NEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGT 462

Query: 946  ---LKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALD 1002
                +++I  L++++  L+ EK        +L+  S   E L+ +++ +S++  L +A +
Sbjct: 463  QAVTEENIASLQKRVVELENEKG-------ALLLSSIELEELKAENEKLSSQITLLEAQN 515

Query: 1003 QAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDK 1045
            +  + ++ +  + S  D A    +S   +G    +    Q+ K
Sbjct: 516  RTGEADREVSEI-SIVDIANKRSSSAEESGQDVLENTFSQKHK 557


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  110 bits (274), Expect = 9e-24
 Identities = 158/701 (22%), Positives = 295/701 (42%), Gaps = 90/701 (12%)

Query: 340  LTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERDLERA---EVAKATSHICEVEKE 395
            LTE  S     I+  T  ++AL+E  QQ ++ L AE D   +     +K    + ++E  
Sbjct: 979  LTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESS 1038

Query: 396  IAL---LKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEE 452
            +     L+   E+   + E  L+ A+  +  +  +K  L  +L+++  +   LQ +VE+E
Sbjct: 1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDE 1098

Query: 453  SITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEEL 512
                   + + +   ARI ELE     E+ +AER  R   + + +  A            
Sbjct: 1099 QTLGLQFQKKIKELQARIEELE-----EEIEAERATRAKTEKQRSDYAR----------- 1142

Query: 513  TLRRGEIEELQQCLLHSGPPPPDHPDA-----AEILRLRERLLSASKEHQRESGVLRDKY 567
                 E+EEL + L  +G       +      AE L+LR  L  A+ +H+     LR K+
Sbjct: 1143 -----ELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKH 1197

Query: 568  EKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKS 627
              ++     ++D L+   +K  +E +  K ++   +S +M  +   K+ L+ +     ++
Sbjct: 1198 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSS-SMESVSKSKANLEKIC----RT 1252

Query: 628  LEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALRE 687
            LED  +         Q+ + EL       K   Q E G L  +        ++EKE++  
Sbjct: 1253 LEDQLSEARGKNEEIQRSLSELTTQ----KSRLQTEAGELSRQ--------LEEKESIVS 1300

Query: 688  KLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQ 747
            +L  +++         + QLE +           Q  R D +L   + E+   E  G+A+
Sbjct: 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEE---EQEGKAE 1357

Query: 748  AIEFLKEQISLAEKKMLDYER--LQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQH 805
                L +  S   +    YE   +QR E + ++  + L ++L  +E +++AV A C+S  
Sbjct: 1358 LQRALSKANSEVAQWRTKYETDAIQRTE-ELEEAKKKLAQRLQDSEEQVEAVNAKCAS-- 1414

Query: 806  THMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEK 865
                    + +   R +  VE L   + + +    AL  +       ++  ++KC+  + 
Sbjct: 1415 --------LEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 1466

Query: 866  KVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPG 925
            +++A LKE R L  EL  +     +A  QL  + +E    E+ + +L   + E       
Sbjct: 1467 ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAEN------ 1520

Query: 926  PERDLSREVHKAEWRIKEQKL-KDDIR-GLREKLTGLDKEKS------LSDQRRYSLIDP 977
                  + +H+ E   K+ +L K DI+  L E    L+ E++      L   +  S ID 
Sbjct: 1521 -----GKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDR 1575

Query: 978  SSA---PELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMR 1015
              A    E+ +L+     T + ++ ALD   +V    EA+R
Sbjct: 1576 KIAEKDEEIEQLKRNYQRTVETMQSALD--AEVRSRNEAIR 1614



 Score = 80.5 bits (197), Expect = 8e-15
 Identities = 137/672 (20%), Positives = 275/672 (40%), Gaps = 115/672 (17%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLV 421
            +E Q+ + +L  ++   + E  + +  + E E  ++ L    + +  + EE  ++    +
Sbjct: 1265 EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ----L 1320

Query: 422  ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGE--------- 472
            E   K K  L++ L+  R   + L+ + EEE   K +L+      ++ + +         
Sbjct: 1321 EEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1380

Query: 473  LEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCL--LHSG 530
            ++++  LE+A+ ++L + L D+     A  ++   LE+     +GE+E+L   +   +S 
Sbjct: 1381 IQRTEELEEAK-KKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 1439

Query: 531  PPPPDHPDA------AEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAA 584
                D          AE     E   +  +   +ES  L  +  K   AY+  +D+L   
Sbjct: 1440 AAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETV 1499

Query: 585  ---NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGA 641
               N+   QE+A L +++ +   + +  ++  + +++   +D Q +LE+ +A L      
Sbjct: 1500 KRENKNLEQEIADLTEQIAE-NGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAK 1558

Query: 642  Q--------------QKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMH---VKEKEA 684
                            ++I E    +E +K  +Q  +  +Q+  D E       ++ K+ 
Sbjct: 1559 ILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKK 1618

Query: 685  LREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRG 744
            +   L E + +L+   R        QA++    L+  Q Q +D +L       LD   RG
Sbjct: 1619 MEGDLNEIEIQLSHANR--------QAAETLKHLRSVQGQLKDTQLH------LDDALRG 1664

Query: 745  QAQAIEFLKEQISLAEKK----MLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEAL 800
            Q    E LKEQ+++ E++      + E L+    Q ++  +   ++LL +  R+Q    L
Sbjct: 1665 Q----EDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQ----L 1716

Query: 801  CSSQHTHMIESNDISEETIRT--KETVEGLQDKLNKRDKEVTALTSQTEM---------- 848
              +Q+T +I +    E  +     E  +  +D  N  +K   A+T    M          
Sbjct: 1717 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1776

Query: 849  ----------LRAQVSALESKC--------KSGEKKVDALLKEKRRLEAELETVSRK-TH 889
                      L   V  L+ +         K G+K++  L    R LE ELE   +K T 
Sbjct: 1777 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTE 1836

Query: 890  DASG---------QLVLISQE----LLRKERSLNELRVLLLEANRHSPGPERDLSREVHK 936
               G         +L   S+E    +LR +  +++L+V +    R +   E D     H 
Sbjct: 1837 SVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQA--EEADEQANAHL 1894

Query: 937  AEWRIKEQKLKD 948
             ++R  + +L++
Sbjct: 1895 TKFRKAQHELEE 1906



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 129/606 (21%), Positives = 243/606 (40%), Gaps = 72/606 (11%)

Query: 462  QTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRV-LQLEEELTLRRGEIE 520
            +T+ E A + E  Q    E A++E   +EL +  +T V EK+ + LQ++ E        E
Sbjct: 845  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904

Query: 521  ELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDK 580
               Q +             A+I  + ER     +E   E    + K E      + ++D 
Sbjct: 905  RCDQLI------KAKFQLEAKIKEVTER-AEDEEEINAELTAKKRKLEDECSELKKDIDD 957

Query: 581  LRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKL----DSLASDHQKSLEDLKATLN 636
            L     K  +E    ++KV+  T E  GL D   +KL     +L   HQ++L+DL+    
Sbjct: 958  LELTLAKVEKEKHATENKVKNLTEELSGL-DETIAKLTREKKALQEAHQQALDDLQ---- 1012

Query: 637  SGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHV---KEKEALREKLQEAQ 693
                A++ ++  L       K+E Q+E  +L++  + E  + V   + K  L   L+ AQ
Sbjct: 1013 ----AEEDKVNSLNKTKS--KLEQQVE--DLESSLEQEKKLRVDLERNKRKLEGDLKLAQ 1064

Query: 694  EELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLK 753
            E +  L+   + QL+ +  +   E  + Q +  D +    + +K   E + +   IE L+
Sbjct: 1065 ESILDLEND-KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQAR---IEELE 1120

Query: 754  EQI-------SLAEKKMLDY--------ERLQRA--------EAQGKQEVESLREKLLVA 790
            E+I       +  EK+  DY        ERL+ A        E   K+E E L+ +  + 
Sbjct: 1121 EEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLE 1180

Query: 791  ENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLR 850
            E  LQ    + + +  H     ++ E+    +   + L+ + ++   E+  L+S  E + 
Sbjct: 1181 EATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240

Query: 851  AQVSALESKCKSGE--------------KKVDALLKEKRRLEAELETVSRKTHDASGQLV 896
               + LE  C++ E              + +  L  +K RL+ E   +SR+  +    + 
Sbjct: 1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300

Query: 897  LISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIRGLREK 956
             +S+      +   EL+  L E N+        L    H  +  +  ++ +++  G  E 
Sbjct: 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCD--LLREQYEEEQEGKAEL 1358

Query: 957  LTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMRS 1016
               L K  S   Q R +  +  +      L+         L+D+ +Q + V     ++  
Sbjct: 1359 QRALSKANSEVAQWR-TKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEK 1417

Query: 1017 CPDKAQ 1022
               + Q
Sbjct: 1418 TKQRLQ 1423



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 124/561 (22%), Positives = 233/561 (41%), Gaps = 76/561 (13%)

Query: 488  LRELADNRLTTVAEKSR------VLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAE 541
            L E+ D+RL  +  +++      ++++E +  ++R E     Q  + S       P    
Sbjct: 774  LEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKL 833

Query: 542  ILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQ 601
              +++  L SA  E ++E   ++++++K          K +   EK    V    D   Q
Sbjct: 834  FFKIKPLLKSA--ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQ 891

Query: 602  ATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQ 661
              +E+  L+D  + + D L     K+   L+A +       + E  E+ A +   K + +
Sbjct: 892  VQAESENLLDA-EERCDQLI----KAKFQLEAKIKEVTERAEDE-EEINAELTAKKRKLE 945

Query: 662  LELGNLQAKHD---LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLEL 718
             E   L+   D   L  A   KEK A   K++   EEL+GL      +   + ++ +  L
Sbjct: 946  DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLD-----ETIAKLTREKKAL 1000

Query: 719  QEAQDQRRD----AELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKM-LDYERLQRAE 773
            QEA  Q  D     E +V+ L K   +   Q + +E   EQ    EKK+ +D ER +R +
Sbjct: 1001 QEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ----EKKLRVDLERNKR-K 1055

Query: 774  AQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLN 833
             +G  +++  +E +L  EN  Q ++     +     +     E+     E   GLQ    
Sbjct: 1056 LEG--DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVED-----EQTLGLQ--FQ 1106

Query: 834  KRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASG 893
            K+ KE          L+A++  LE + ++         K++     ELE +S +  +A G
Sbjct: 1107 KKIKE----------LQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGG 1156

Query: 894  QLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREV--HKAEWRIKEQKLKDDIR 951
              V  +Q  L K+R    L++             RDL      H+A      +K  D + 
Sbjct: 1157 --VTSTQIELNKKREAEFLKL------------RRDLEEATLQHEAMVAALRKKHADSVA 1202

Query: 952  GLREKLTGLDKEKSLSDQR----RYSLIDPSSAPELL-----RLQHQLMSTEDALRDALD 1002
             L E++  L + K   ++     +  + D SS+ E +      L+    + ED L +A  
Sbjct: 1203 ELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARG 1262

Query: 1003 QAQQVEKLMEAMRSCPDKAQT 1023
            + +++++ +  + +   + QT
Sbjct: 1263 KNEEIQRSLSELTTQKSRLQT 1283



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 97/452 (21%), Positives = 183/452 (40%), Gaps = 81/452 (17%)

Query: 359  EALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRAR 418
            E +K + +++EQ +A+   + AE  K    + +  K+I L KA  +  + EAE  L+   
Sbjct: 1497 ETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEE 1556

Query: 419  LLVESVRKE----KVDLSNQLEEERRKVE-----------------DLQFRVEEESIT-- 455
              +  ++ E    K ++  ++ E+  ++E                 D + R   E+I   
Sbjct: 1557 AKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLK 1616

Query: 456  ---KGDL-ETQTQLEHARIGELEQSLLLEKAQAERLLREL-ADNRLTTVAE-KSRVLQLE 509
               +GDL E + QL HA     E    L   Q +    +L  D+ L    + K ++  +E
Sbjct: 1617 KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 1676

Query: 510  EELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKE---HQRESGVL--R 564
                L + E+EEL+  L        +  + A  L  +E L S  +    H + + ++  +
Sbjct: 1677 RRANLLQAEVEELRATL--------EQTERARKLAEQELLDSNERVQLLHTQNTSLIHTK 1728

Query: 565  DKYEKALKAYQAEVDKL----RAANEKYAQEV--AGLKDKVQQATSENMGLMDNWKSKLD 618
             K E  L   Q+EV+      R A EK  + +  A +  +  +   +    ++  K  L+
Sbjct: 1729 KKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 1788

Query: 619  SLASDHQKSLEDLKATLNSGPGAQQKEI------------GELKAVMEGIK--------- 657
                D Q  L++ +     G   Q +++            GE K   E +K         
Sbjct: 1789 QTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRV 1848

Query: 658  ----MEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQ 713
                 + + +  N+    DL   + VK K   R+  +  ++  A L +  +AQ E++ ++
Sbjct: 1849 KELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAE 1908

Query: 714  HRLELQEAQDQRRDAELR--------VHELEK 737
             R ++ E+Q  +  A+ R        VHE E+
Sbjct: 1909 ERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 63/270 (23%), Positives = 111/270 (41%), Gaps = 35/270 (12%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L+  + + A  +    ++Q  LK+ Q H++  L  ++  + ++A        ++ E+  L
Sbjct: 1630 LSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEEL 1689

Query: 400  KAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSN-QLEEERRKVE----DLQFRVEEESI 454
            +A  EQ   E   KL    LL  + R + +   N  L   ++K+E     LQ  VE+ S 
Sbjct: 1690 RATLEQ--TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASR 1747

Query: 455  TKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTL 514
               + E + +        + + L  E+  +  L R +  N   TV +    L   E+L L
Sbjct: 1748 DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER-MKKNLEQTVKDLQHRLDEAEQLAL 1806

Query: 515  RRG--EIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALK 572
            + G  +I++L+                  I  L   L    K++      LR KYE+ +K
Sbjct: 1807 KGGKKQIQKLE----------------TRIRELEFELEGEQKKNTESVKGLR-KYERRVK 1849

Query: 573  --AYQAEVDKLRAANEKYAQEVAGLKDKVQ 600
               YQ+E D+      K    +  L DK+Q
Sbjct: 1850 ELTYQSEEDR------KNVLRLQDLVDKLQ 1873


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  109 bits (273), Expect = 1e-23
 Identities = 163/728 (22%), Positives = 314/728 (43%), Gaps = 110/728 (15%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            LTE  +     I+  T  ++AL+E  Q   Q L +  +E  +V   +    ++E+++  L
Sbjct: 980  LTEEMAGLDEIIAKLTKEKKALQEAHQ---QALDDLQVEEDKVNSLSKSKVKLEQQVDDL 1036

Query: 400  KAQHEQYVAEAEEKLQRARLLVES----VRKEKVDLSN---QLEEERRKVE----DLQFR 448
            +   EQ   +    L+RA+  +E      ++  +DL N   QLEE+ +K E        +
Sbjct: 1037 EGSLEQE-KKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSK 1095

Query: 449  VEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQL 508
            +E+E +    L+ + +   ARI ELE+ L     +AER  R             ++V +L
Sbjct: 1096 IEDEQVLALQLQKKLKENQARIEELEEEL-----EAERTAR-------------AKVEKL 1137

Query: 509  EEELTLRRGEIEELQQCLLHSGPPPP-----DHPDAAEILRLRERLLSASKEHQRESGVL 563
              +L+    E+EE+ + L  +G         +    AE  ++R  L  A+ +H+  +  L
Sbjct: 1138 RSDLSR---ELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194

Query: 564  RDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLA-- 621
            R K+  ++     ++D L+   +K  +E +  K ++   TS NM  +   K+ L+ ++  
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS-NMEQIIKAKANLEKVSRT 1253

Query: 622  ------------SDHQKSLEDL---KATLNSGPGAQQKEIGELKAVMEGI---KMEHQLE 663
                         + Q+SL D    +A L +  G   +++ E +A++  +   K+ +  +
Sbjct: 1254 LEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQ 1313

Query: 664  LGNLQAK------------HDLETAMHVKEKEALREKLQEAQEELAGLQR---------- 701
            + +L+ +            H L++A H  + + LRE+ +E  E  A LQR          
Sbjct: 1314 MEDLKRQLEEEGKAKNALAHALQSARH--DCDLLREQYEEETEAKAELQRVLSKANSEVA 1371

Query: 702  HWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQI-SLAE 760
             WR + E  A Q   EL+EA   ++    R+ + E+       +  ++E  K ++ +  E
Sbjct: 1372 QWRTKYETDAIQRTEELEEA---KKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIE 1428

Query: 761  KKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIR 820
              M+D ER   A A   ++  +  +K+L      Q  E   S   +   E+  +S E  +
Sbjct: 1429 DLMVDVERSNAAAAALDKKQRNF-DKILAEWK--QKYEESQSELESSQKEARSLSTELFK 1485

Query: 821  TKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAE 880
             K   E   + L    +E        + L+ ++S L  +   G K V  L K +++LE E
Sbjct: 1486 LKNAYEESLEHLETFKRE-------NKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVE 1538

Query: 881  LETVSRKTHDASGQLVLISQELLRKERSLNELRV----LLLEANRHSPGPERDLSREVHK 936
               +     +A   L     ++LR +   N+++      L E +      +R+  R V  
Sbjct: 1539 KLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDS 1598

Query: 937  AEWRI-KEQKLKDDIRGLREKLTG--LDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMST 993
             +  +  E + ++++  +++K+ G   + E  LS   R +     +  ++  LQ  L  T
Sbjct: 1599 LQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMA---AEAQKQVKSLQSLLKDT 1655

Query: 994  EDALRDAL 1001
            +  L DA+
Sbjct: 1656 QIQLDDAV 1663



 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 157/749 (20%), Positives = 305/749 (40%), Gaps = 112/749 (14%)

Query: 361  LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLL 420
            L+  +Q +E+  +E  LE  +V      I + +  +  +    E    E   KL+ A+  
Sbjct: 1212 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRS 1271

Query: 421  VESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQ----- 475
            +     ++  L  +  E  R++E+ +  + +  +T+G L    Q+E  +  +LE+     
Sbjct: 1272 LNDFTTQRAKLQTENGELARQLEEKEALISQ--LTRGKLSYTQQMEDLK-RQLEEEGKAK 1328

Query: 476  SLLLEKAQAER----LLRELADNRLTTVAEKSRVL------------QLEEELTLRRGEI 519
            + L    Q+ R    LLRE  +      AE  RVL            + E +   R  E+
Sbjct: 1329 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL 1388

Query: 520  EELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEH-QRESGVLRDKYEK------ALK 572
            EE ++ L        D  +A E +  +   L  +K   Q E   L    E+      AL 
Sbjct: 1389 EEAKKKLAQR---LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALD 1445

Query: 573  AYQAEVDKLRAA-NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDL 631
              Q   DK+ A   +KY +  + L+   ++A S +        ++L  L + +++SLE L
Sbjct: 1446 KKQRNFDKILAEWKQKYEESQSELESSQKEARSLS--------TELFKLKNAYEESLEHL 1497

Query: 632  KATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQE 691
            +         Q++     + + EG K  H+LE    + +  LE      EK  L+  L+E
Sbjct: 1498 ETFKRENKNLQEEISDLTEQLGEGGKNVHELE----KVRKQLEV-----EKLELQSALEE 1548

Query: 692  AQEELAGLQ-RHWRAQLEVQASQHRLEL------QEAQDQRRDAELRVHELE-KLDVEYR 743
            A+  L   + +  RAQLE    +  +E       +E +  +R+ +  V  L+  LD E R
Sbjct: 1549 AEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETR 1608

Query: 744  GQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESL-------------------- 783
             + + +   K+      +  +      R  A+ +++V+SL                    
Sbjct: 1609 SRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDD 1668

Query: 784  -REKLLVAENRLQAVEALCSSQHTHMIESNDIS-----EETIRTKETVEGLQDKLNKRDK 837
             +E + + E R   ++A        ++E  + S     +E I T E V+ L  +      
Sbjct: 1669 LKENIAIVERRNNLLQAELEELRA-VVEQTERSRKLAEQELIETSERVQLLHSQNTSLIN 1727

Query: 838  EVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVL 897
            +   + S    L+++V     +C++ E+K    + +   +  EL    +K  D S  L  
Sbjct: 1728 QKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEEL----KKEQDTSAHLER 1783

Query: 898  ISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIK--EQKLKDDIRGLRE 955
            + + +   E+++ +L+  L EA + +    +   +++ K E R++  E +L+ + +   E
Sbjct: 1784 MKKNM---EQTIKDLQHRLDEAEQIA---LKGGKKQLQKLEARVRELEGELEAEQKRNAE 1837

Query: 956  KLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLMEAMR 1015
             + G+ K +    +  Y   +      LLRLQ  +   +  ++    QA++ E+      
Sbjct: 1838 SVKGMRKSERRIKELTYQTEEDKK--NLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL 1895

Query: 1016 SCPDKAQTIGNSGSANGIHQQDKAQKQED 1044
            S   K Q           H+ D+A+++ D
Sbjct: 1896 SKFRKVQ-----------HELDEAEERAD 1913



 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 152/739 (20%), Positives = 305/739 (41%), Gaps = 114/739 (15%)

Query: 350  KISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAE 409
            K + T      +KE+   I++ L + +  R E+ +    + + + ++ L     +  + +
Sbjct: 843  KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902

Query: 410  AEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHAR 469
            AEE+        + + K K+ L  +++E   ++ED +    E +  K  LE +       
Sbjct: 903  AEERC-------DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKD 955

Query: 470  IGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVL-QLEEELTLRRGEIEELQQCLLH 528
            I +LE  L L K + E   +   +N++  + E+   L ++  +LT  +  ++E  Q  L 
Sbjct: 956  IDDLE--LTLAKVEKE---KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1010

Query: 529  SGPPPPDHPDAAEILRLR--------ERLLSASKEHQRESGVLRDKYEKALKAYQAEV-- 578
                  D  ++    +++        E  L   K+ + +    + K E  LK  Q  +  
Sbjct: 1011 DLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMD 1070

Query: 579  ---------DKLRAANEKYAQEVAGLKD------KVQQATSENMGLMDNW---------- 613
                     +KL+       Q+ + ++D      ++Q+   EN   ++            
Sbjct: 1071 LENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTA 1130

Query: 614  KSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIG-ELKAVMEGIKMEHQLELGNLQAKHD 672
            ++K++ L SD  + LE++   L    GA   +I    K   E  KM   LE   LQ +  
Sbjct: 1131 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHE-- 1188

Query: 673  LETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEA----------- 721
              TA  +++K A  + + E  E++  LQR  + +LE + S+ +LEL +            
Sbjct: 1189 -ATAAALRKKHA--DSVAELGEQIDNLQR-VKQKLEKEKSEFKLELDDVTSNMEQIIKAK 1244

Query: 722  ----------QDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQIS--LAEKKMLDYERL 769
                      +DQ  +  +++ E ++   ++  Q   ++    +++  L EK+ L   +L
Sbjct: 1245 ANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEAL-ISQL 1303

Query: 770  QRAEAQGKQEVESLREKLL---VAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVE 826
             R +    Q++E L+ +L     A+N L    AL S++H   +      EET   K  ++
Sbjct: 1304 TRGKLSYTQQMEDLKRQLEEEGKAKNAL--AHALQSARHDCDLLREQYEEET-EAKAELQ 1360

Query: 827  GLQDKLNK-----RDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDA-------LLKEK 874
             +  K N      R K  T    +TE L      L  + +  E+ V+A       L K K
Sbjct: 1361 RVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTK 1420

Query: 875  RRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEAN---RHSPGPERDLS 931
             RL+ E+E +      ++     + ++    ++ L E +    E+      S    R LS
Sbjct: 1421 HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLS 1480

Query: 932  REVHKAEWRIKE-----QKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRL 986
             E+ K +   +E     +  K + + L+E+++ L ++     +         +  EL ++
Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGK---------NVHELEKV 1531

Query: 987  QHQLMSTEDALRDALDQAQ 1005
            + QL   +  L+ AL++A+
Sbjct: 1532 RKQLEVEKLELQSALEEAE 1550



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 75/322 (23%), Positives = 141/322 (43%), Gaps = 41/322 (12%)

Query: 723  DQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQR------AEAQG 776
            D R+  E  +  L+    +Y+     + F    + L E+ M D ERL R      A+A+G
Sbjct: 739  DSRKGTEKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEE-MRD-ERLSRIITRMQAQARG 796

Query: 777  K------QEVESLREKLLVAENRLQA---------------VEALCSSQHTHMIESNDIS 815
            +      +++   R+ LLV +  ++A               ++ L  S  T   E   + 
Sbjct: 797  QLMRIEFKKIVERRDALLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEK-EMATMK 855

Query: 816  EETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKR 875
            EE  R KET+E  + +  + ++++ +L  +   L+ QV A +      E++ D L+K K 
Sbjct: 856  EEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKI 915

Query: 876  RLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVH 935
            +LEA+++ ++ +  D       ++ EL  K+R L +    L +           + +E H
Sbjct: 916  QLEAKVKEMNERLEDEEE----MNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 971

Query: 936  KAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPE-----LLRLQHQL 990
              E ++K   L +++ GL E +  L KEK    +     +D     E     L + + +L
Sbjct: 972  ATENKVK--NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKL 1029

Query: 991  MSTEDALRDALDQAQQVEKLME 1012
                D L  +L+Q ++V   +E
Sbjct: 1030 EQQVDDLEGSLEQEKKVRMDLE 1051



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 87/399 (21%), Positives = 170/399 (42%), Gaps = 69/399 (17%)

Query: 357  LQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEK--EIALLKAQHEQYVAEAEEKL 414
            ++  L EK + +EQ  A+R+ +R   +  TS   E     E+  +K + E  + E E +L
Sbjct: 1574 IERKLAEKDEEMEQ--AKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQL 1631

Query: 415  QRARLLVESVRKEKVDLSN-------QLEEERRKVEDLQFRVEEESITKGDLETQTQLEH 467
              A  +    +K+   L +       QL++  R  +DL+  +         +E +  L  
Sbjct: 1632 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI-------AIVERRNNLLQ 1684

Query: 468  ARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVL------------QLEEELTLR 515
            A + EL   +     Q ER  R+LA+  L   +E+ ++L            ++E +LT  
Sbjct: 1685 AELEELRAVV----EQTER-SRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQL 1739

Query: 516  RGEIEE-LQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAY 574
            + E+EE +Q+C            DAA +    ++    S   +R    ++   E+ +K  
Sbjct: 1740 QSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER----MKKNMEQTIKDL 1795

Query: 575  QAEVDKL-RAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKA 633
            Q  +D+  + A +   +++  L+ +V++   E              L ++ +++ E +K 
Sbjct: 1796 QHRLDEAEQIALKGGKKQLQKLEARVRELEGE--------------LEAEQKRNAESVK- 1840

Query: 634  TLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQ 693
                G    ++ I EL    E  K        NL    DL   + +K K A + + +EA+
Sbjct: 1841 ----GMRKSERRIKELTYQTEEDKK-------NLLRLQDLVDKLQLKVK-AYKRQAEEAE 1888

Query: 694  EEL-AGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELR 731
            E+    L +  + Q E+  ++ R ++ E+Q  +  A+ R
Sbjct: 1889 EQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSR 1927


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  108 bits (271), Expect = 2e-23
 Identities = 181/764 (23%), Positives = 328/764 (42%), Gaps = 108/764 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVE---KEI 396
            L+E  ++Y    +    LQ+  +EK+QH  QL +E +   +++ +    + E     KE 
Sbjct: 381  LSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ 440

Query: 397  ALLKAQ----HEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEE--ERRKVEDLQFRVE 450
              L ++     EQ VA+ + KL R    +E   KEKV  S +L+   ++ K +  + +  
Sbjct: 441  RQLSSEKLMDKEQQVADLQLKLSR----LEEQLKEKVTNSTELQHQLDKTKQQHQEQQAL 496

Query: 451  EESITKGDLETQTQLEHA--RIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQL 508
            ++S T    E Q  LE    +IG+ +Q +       E LL++  +N   ++ EK R   L
Sbjct: 497  QQSTTAKLREAQNDLEQVLRQIGDKDQKI----QNLEALLQKSKEN--ISLLEKERE-DL 549

Query: 509  EEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYE 568
              ++    GE   L Q          +H    ++ +L E+L + S+ H++    L D+ +
Sbjct: 550  YAKIQAGEGETAVLNQL------QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQ 603

Query: 569  KA---LKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQ 625
            +    L+A Q  V  L  +  +   ++   K+KV Q     + +    K++L  L+++  
Sbjct: 604  EQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQ-----LDIQIKAKTEL-LLSAEAA 657

Query: 626  KSLE--DLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLE--LGNLQAK--HDLETAMHV 679
            K+ +  DL+  L++   A Q +  EL       K+  QL+     LQ K  H  +   H+
Sbjct: 658  KTAQRADLQNHLDTAQNALQDKQQELN------KITTQLDQVTAKLQDKQEHCSQLESHL 711

Query: 680  KEKEALREKLQEAQEELAGLQRHWRA-QLEVQASQHRLELQEAQDQRR---DAELRVHEL 735
            KE +     L++  EEL G  +   A  LEV+AS+ +  LQ+ Q QR+   D ELR  EL
Sbjct: 712  KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ-ALQDLQQQRQLNTDLELRATEL 770

Query: 736  EK-LDVE----------YRGQAQAIEFLKEQIS-LAEKKMLDYERLQRAEAQGKQEVESL 783
             K L++E           + +++A+E +K++++   E+K +  +  +    + K + E L
Sbjct: 771  SKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL 830

Query: 784  REKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALT 843
              ++      LQ V+          +E   +  E    K+ +  + D L     E     
Sbjct: 831  NNRIQTTVTELQKVK----------MEKEALMTELSTVKDKLSKVSDSLKNSKSE---FE 877

Query: 844  SQTEMLRAQVSALESKCK----SGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLIS 899
             + +  +A +  LE  CK      + +++  LKE++ L+  LE     +H    +L  + 
Sbjct: 878  KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ 937

Query: 900  QELLRKERSL--NELRVLLLEANRH---SPGPERDLSREVHKAEWRIK-------EQKLK 947
            ++L++ + +L  NE     L+ N +       ++    E  + E +I        E KL+
Sbjct: 938  EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQ 997

Query: 948  DDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQV 1007
              +    ++L   +KEK    Q  Y      S     +LQ      E  L       + V
Sbjct: 998  QQLTQAAQELAA-EKEKISVLQNNYE----KSQETFKQLQSDFYGRESELLATRQDLKSV 1052

Query: 1008 -EKLMEAMRSCPDKAQTIGNSG-------SANGIHQQDKAQKQE 1043
             EKL  A          IGN         +A    +QD A+K++
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQ 1096



 Score =  103 bits (258), Expect = 6e-22
 Identities = 158/763 (20%), Positives = 326/763 (42%), Gaps = 90/763 (11%)

Query: 340  LTETSSRYARKISGTTALQEAL-KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIAL 398
            L+    +   K++ +T LQ  L K KQQH EQ   ++    A++ +A + + +V ++I  
Sbjct: 462  LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTT-AKLREAQNDLEQVLRQIG- 519

Query: 399  LKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLS-------------NQLEEERRKVEDL 445
                 +Q +   E  LQ+++  +  + KE+ DL              NQL+E+   +++ 
Sbjct: 520  ---DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576

Query: 446  QFRVEEESITKGDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSR- 504
              ++ E+   + +   Q Q E+      EQ   L  AQ   L  E + N L +   +S+ 
Sbjct: 577  VTQLTEKLKNQSESHKQAQ-ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKE 635

Query: 505  -VLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAE--ILRLRERLLSASKEHQRESG 561
             V QL+ ++  +   +   +           +H D A+  +   ++ L   + +  + + 
Sbjct: 636  KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695

Query: 562  VLRDKYEKA------LKAYQAEVDKLRAANEKYAQEVAGLK-DKVQQATSENMGLMDNWK 614
             L+DK E        LK Y+ +   L    E+   ++  L+ D ++   S+   L D  +
Sbjct: 696  KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755

Query: 615  SK-----LDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGI-KMEHQLELGNLQ 668
             +     L+  A++  K LE  K  ++S     QK+   L+++ + + K E + ++    
Sbjct: 756  QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQI---- 811

Query: 669  AKHDLETAMHVK--EKEALREKLQEAQEELAGLQRHWRAQL-EVQASQHRLEL------- 718
             K D ET       + E L  ++Q    EL  ++    A + E+   + +L         
Sbjct: 812  LKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKN 871

Query: 719  --QEAQDQRRDAELRVHELEKL--DVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEA 774
               E + + +  +  + +LEK   +++++ Q Q    LKEQ  L  KK L+ E+   A  
Sbjct: 872  SKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKEL--KKSLEKEK--EASH 927

Query: 775  QGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQDKL-- 832
            Q K E+ S++E+L+ A+N L+  E     +       N++ + + + K+ +E LQ +L  
Sbjct: 928  QLKLELNSMQEQLIQAQNTLKQNE---KEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984

Query: 833  ---------NKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELET 883
                     NK  +++T    +    + ++S L++  +  ++    L  +    E+EL  
Sbjct: 985  AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLA 1044

Query: 884  VSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE 943
              +       +L L  ++L+     +     L+ E        E+D ++         KE
Sbjct: 1045 TRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAK---------KE 1095

Query: 944  QKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMST---EDALRDA 1000
            Q+L++  + L++    + KEKSL ++   +     +  E ++ + +   T   E+     
Sbjct: 1096 QQLQERCKALQD----IQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK 1151

Query: 1001 LDQAQQVEKLMEAMR-SCPDKAQTIGNSGSANGIHQQDKAQKQ 1042
            L+  +++  L +A +     K +  G + S     +Q+K  +Q
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQ 1194



 Score =  101 bits (251), Expect = 4e-21
 Identities = 134/697 (19%), Positives = 301/697 (43%), Gaps = 68/697 (9%)

Query: 351  ISGTTALQEALKEKQQHIEQLLAERDLE----RAEVAKATSHICEVEKEIALLK---AQH 403
            I     L++ L + Q  ++ +  ER+ E    + E  K  S     E  I+ L+   A+ 
Sbjct: 220  IEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKG 279

Query: 404  EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQT 463
             Q VA   ++LQ+ +  V  + ++   L+  L ++ +    L+ +  EES++K +++   
Sbjct: 280  PQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATL 339

Query: 464  QLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQ 523
              +     +L+  L   +    R+  EL++    T   K  + ++E +    + E ++LQ
Sbjct: 340  HQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399

Query: 524  QCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRA 583
            Q               +EI +L  +LL   ++     G L+++ + + +    +  ++  
Sbjct: 400  Q--QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD 457

Query: 584  ANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQ 643
               K ++    LK+KV  +T          + +LD     HQ+     +A   S     +
Sbjct: 458  LQLKLSRLEEQLKEKVTNST--------ELQHQLDKTKQQHQEQ----QALQQSTTAKLR 505

Query: 644  KEIGELKAVMEGIKMEHQLELGNLQA---KHDLETAMHVKEKEALREKLQEAQEELAGLQ 700
            +   +L+ V+  I  + Q ++ NL+A   K     ++  KE+E L  K+Q  + E A L 
Sbjct: 506  EAQNDLEQVLRQIGDKDQ-KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564

Query: 701  --RHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISL 758
              +     L+ Q +Q   +L+   +  + A+  +H+              ++  K  +  
Sbjct: 565  QLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD-------------QVQEQKAHLRA 611

Query: 759  AEKKMLDYE----RLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDI 814
            A+ ++L  E     L     + K++V  L  ++      L + EA  ++Q   +    D 
Sbjct: 612  AQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDT 671

Query: 815  SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEK 874
            ++  ++ K      Q +LNK   ++  +T++ +  +   S LES  K  ++K  +L ++ 
Sbjct: 672  AQNALQDK------QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKT 725

Query: 875  RRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREV 934
              LE +++ +   + +         Q+L ++ +   +L +   E ++     + ++ +E+
Sbjct: 726  EELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSK-----QLEMEKEI 780

Query: 935  HKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTE 994
              +  R+  QK  + +  +++KLT  ++EK +  Q      D  +  +  ++QH+ ++  
Sbjct: 781  -VSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQ------DFETLSQETKIQHEELN-- 831

Query: 995  DALRDALDQAQQV----EKLMEAMRSCPDKAQTIGNS 1027
            + ++  + + Q+V    E LM  + +  DK   + +S
Sbjct: 832  NRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDS 868



 Score =  100 bits (248), Expect = 9e-21
 Identities = 155/671 (23%), Positives = 281/671 (41%), Gaps = 106/671 (15%)

Query: 411  EEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEES------------ITKGD 458
            E  L   R  V  +R+E  DL   L+EE+   E+L+  +E+              +T   
Sbjct: 75   ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134

Query: 459  LETQT---QLEHARIG--ELEQSLLLEKAQAERLLRELAD-------NRLTTVAEKSRVL 506
             E Q+   QLE A+     ++Q   L + +A +L  E+AD        R    A + +V 
Sbjct: 135  AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVT 194

Query: 507  QLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA----EILRLRERLLSASKEHQRESGV 562
            +L EEL      I++L+  LL      P   D A    E+++++  + + + E +RES  
Sbjct: 195  RLTEELNKEATVIQDLKTELLQR----PGIEDVAVLKKELVQVQTLMDNMTLERERESEK 250

Query: 563  LRDKYEKALKAY---QAEVDKLRAANEK-------YAQEVAGLKDKVQQATSENMGLMDN 612
            L+D+ +K    Y   +A + +LR+   K       Y QE+  LK  V + T +N  L +N
Sbjct: 251  LKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310

Query: 613  WKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHD 672
               K        +K  E+  +  N      QK+                L+   LQ++  
Sbjct: 311  LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKD----------------LDCQQLQSRLS 354

Query: 673  L-ETAMH-----VKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRR 726
              ET++H     + EK    +KL+E   E+    +H +A+ + Q  Q R E ++   Q +
Sbjct: 355  ASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFK-QLQQQREEKEQHGLQLQ 413

Query: 727  DAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYE--------RLQRAEAQGKQ 778
                ++H   KL    R   +A   LKEQ  L+ +K++D E        +L R E Q K+
Sbjct: 414  SEINQLH--SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKE 471

Query: 779  EVES---LREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIR----TKETVEGLQDK 831
            +V +   L+ +L   + + Q  +AL  S    + E+ +  E+ +R      + ++ L+  
Sbjct: 472  KVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEAL 531

Query: 832  LNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDA 891
            L K  + ++ L  + E L A++ A E +                   A L  +  K H  
Sbjct: 532  LQKSKENISLLEKEREDLYAKIQAGEGE------------------TAVLNQLQEKNHTL 573

Query: 892  SGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDDIR 951
              Q+  ++++L  +  S  + +  L +  +      R     V   E  + E  L   + 
Sbjct: 574  QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNE--LNSQLN 631

Query: 952  GLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVEKLM 1011
              +EK++ LD +     +   S  + +   +   LQ+ L + ++AL+   D+ Q++ K+ 
Sbjct: 632  ESKEKVSQLDIQIKAKTELLLS-AEAAKTAQRADLQNHLDTAQNALQ---DKQQELNKIT 687

Query: 1012 EAMRSCPDKAQ 1022
              +     K Q
Sbjct: 688  TQLDQVTAKLQ 698



 Score = 94.4 bits (233), Expect = 5e-19
 Identities = 157/669 (23%), Positives = 283/669 (42%), Gaps = 131/669 (19%)

Query: 354  TTALQEA---LKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEA 410
            TT L +    L++KQ+H  QL +     + +         E+E +I  L+A   +  A  
Sbjct: 687  TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 746

Query: 411  EEKLQ---RARLLVESVRKEKVDLSNQLEEERRKVE----DLQFRVE------------- 450
            E+ LQ   + R L   +     +LS QLE E+  V     DLQ + E             
Sbjct: 747  EQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQE 806

Query: 451  -EESITKGDLET---QTQLEHARIGELEQSLLLE----KAQAERLLRELAD--NRLTTVA 500
             E+ I K D ET   +T+++H  +    Q+ + E    K + E L+ EL+   ++L+ V+
Sbjct: 807  EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVS 866

Query: 501  E----------------KSRVLQLEE-------------ELTLRRGEIEELQQCLLHSGP 531
            +                K+ +L LE+             E TL+  E +EL++ L     
Sbjct: 867  DSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLK--EQKELKKSL--EKE 922

Query: 532  PPPDHPDAAEILRLRERLLSAS-------KEHQRESGVLRD------KYEKALKAYQAEV 578
                H    E+  ++E+L+ A        KE Q+  G + +      + +K ++A Q E+
Sbjct: 923  KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 982

Query: 579  -----------DKLRAANEKYAQEVAGLKDKV--------------QQATSENMGLMDNW 613
                       +KL+    + AQE+A  K+K+              +Q  S+  G     
Sbjct: 983  KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042

Query: 614  KSKLDSLASDHQK---SLEDLKATLNSGPGAQQKEIGELKAV-----MEGIKMEHQLELG 665
             +    L S  +K   + EDL +  N   G Q K I ELK        +  K E QL+  
Sbjct: 1043 LATRQDLKSVEEKLSLAQEDLISNRNQ-IGNQNKLIQELKTAKATLEQDSAKKEQQLQ-E 1100

Query: 666  NLQAKHDLETAMHVKEKEALREKLQEAQ-EELAGLQRHWRAQLEVQASQHRLELQEAQDQ 724
              +A  D++    +KEKE + EK + A+ EE+   Q     +L  +   H+LE  +    
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160

Query: 725  RRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLR 784
             +DA+     L +  +E +G+A +++   EQ    ++ + D         Q K+E E L+
Sbjct: 1161 LKDAK---QLLIQQKLELQGKADSLKAAVEQEKRNQQILKD---------QVKKEEEELK 1208

Query: 785  EKLLVAENRLQA-VEALCSSQHTHMIESNDISEETIRTKETVEGLQDKLNKRDKEVTALT 843
            ++ +  E +L + ++        H      ++ +     E +  ++ +     + V+ L 
Sbjct: 1209 KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELE 1268

Query: 844  SQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQL---VLISQ 900
             QT+ LR +++ LE+  ++ + +  ALL+   + E E+E +  K  +   +L       Q
Sbjct: 1269 KQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQ 1328

Query: 901  ELLRKERSL 909
            EL R+ +SL
Sbjct: 1329 ELGRENQSL 1337



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 63/260 (24%), Positives = 121/260 (46%), Gaps = 40/260 (15%)

Query: 356  ALQEALKEKQQHIEQLLAERDL--ERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEK 413
            ALQ+  KEK       L E++L  E++++A+     C  EKEI  L  + + +  E+ ++
Sbjct: 1104 ALQDIQKEKS------LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKE 1157

Query: 414  LQRARLLVESVRKEKVDLSNQ-------LEEERRKVEDL--QFRVEEESITKGDLETQTQ 464
            +   +   + + ++K++L  +       +E+E+R  + L  Q + EEE + K  +E + +
Sbjct: 1158 ITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAK 1217

Query: 465  LEHARIGELEQSLLLEKAQAERLLRELA--DNRLTTV-----AEKSRVLQLEEELTLRRG 517
            L H+ I E E  +   +    +L  ++   +  L TV     + + RV +LE++    RG
Sbjct: 1218 L-HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRG 1276

Query: 518  EIEELQ---------------QCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGV 562
            EI  L+               +CL   G          E+ R  +   +A +E  RE+  
Sbjct: 1277 EIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQS 1336

Query: 563  LRDKYEKALKAYQAEVDKLR 582
            L+ K+ +AL    AE ++++
Sbjct: 1337 LQIKHTQALNRKWAEDNEVQ 1356



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 53/239 (22%), Positives = 113/239 (47%), Gaps = 26/239 (10%)

Query: 815  SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEK 874
            SEE  +  E  +GLQ +  K D  VT  +++ + L  Q+   +++  + ++  D   ++ 
Sbjct: 106  SEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKA 165

Query: 875  RRLEAELETVSRKTHD-------ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPE 927
             +L  E+  +  K  +       A  ++  +++EL ++   + +L+  LL+     PG E
Sbjct: 166  AQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQ----RPGIE 221

Query: 928  RDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQ 987
             D++  V K E  ++ Q L D++   RE+ +   K++    Q +Y+    SS   + +L+
Sbjct: 222  -DVA--VLKKE-LVQVQTLMDNMTLERERESEKLKDECKKLQSQYA----SSEATISQLR 273

Query: 988  HQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQEDKH 1046
             +L       ++     Q+++KL  ++     K QT+    + N + ++    K E+KH
Sbjct: 274  SELAK---GPQEVAVYVQELQKLKSSVNELTQKNQTL----TENLLKKEQDYTKLEEKH 325


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  108 bits (271), Expect = 2e-23
 Identities = 149/678 (21%), Positives = 285/678 (42%), Gaps = 80/678 (11%)

Query: 325  SVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKE---KQQHIEQLLAERDLERAE 381
            S+A+       R   L E   R   K+     L+E  ++   +Q  + Q  A++ L+  E
Sbjct: 1993 SLAAEEEAARQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051

Query: 382  VAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRK 441
             A A + + + E+E+     Q +  + +   + + AR   E   + +V    +  + RR+
Sbjct: 2052 KAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 442  VED---LQFRVEEESITKGD-------LETQTQLEHARIGELEQSLLLEKAQAERLLREL 491
            VE+   L+   EE++  +         L  + + E AR  + EQ+ L +K  A+  + + 
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170

Query: 492  ADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLS 551
                  T+ +K+   Q+E+ELT  R ++EE             DH        L +  L 
Sbjct: 2171 KKFAEQTLRQKA---QVEQELTTLRLQLEET------------DHQK-----NLLDEELQ 2210

Query: 552  ASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGL----KDKVQ---QATS 604
              K    E+   R + E+ L + + ++++L     +   E   L    KD  Q   Q  +
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2270

Query: 605  ENMGLMDNWKSKLDSLASD----HQKSLEDLKATLNSGPGAQQKEIGE------LKAVME 654
            E M  +    ++L   A +     Q + EDL         AQQ+ + E      ++AV E
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDL---------AQQRALAEKMLKEKMQAVQE 2321

Query: 655  GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA----QLEVQ 710
              +++ + EL  LQ + +L      + +E   +  Q+  EE  G QR   A    QLE+ 
Sbjct: 2322 ATRLKAEAEL--LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2379

Query: 711  ASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA-EKKMLDYERL 769
            A   RL+L+ A+  R  A       E+    +R QA+ I     +  LA ++K+   + L
Sbjct: 2380 AEAERLKLRVAEMSRAQARA-----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2434

Query: 770  QRAEAQGKQEVESLREKLLVAENRLQAVEALCS-----SQHTHMIESNDISEETIRTKET 824
            +    Q   + E LRE +   E   + ++         S+    ++   + +ET   +++
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494

Query: 825  VEGLQDKLNKRDKEVTALTSQTEML-RAQVSALESKCKSGEKKVDALLKEKRRLEAELET 883
                +D L +R++ +    ++ E L + +V+  +   +  +++   + +E++RL A +E 
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2554

Query: 884  VSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE 943
              R+ H+A   +    +EL + E+   +   LL E N+     +  L  E H+A     E
Sbjct: 2555 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLLEEQHRAALAHSE 2613

Query: 944  QKLKDDIRGLREKLTGLD 961
            +     +   +    G D
Sbjct: 2614 EVTASQVAATKTLPNGRD 2631



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 149/701 (21%), Positives = 296/701 (42%), Gaps = 101/701 (14%)

Query: 352  SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            SG+ ++ +   + + H  +L          +++    + E E+     +A+  + +AE E
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
              L++ R L E+  + K        +  R+ ++LQ R++EE + + +     Q +   I 
Sbjct: 1367 AALEKQRQLAEAHAQAKA-------QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGP 531
            E E   L + ++AE      A  R    AE+SR L++EEE+ + R ++E  ++     G 
Sbjct: 1420 E-ELQQLRQSSEAE----IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER---QRGG 1470

Query: 532  PPPDHPDAAEILRLRERLLSASKEHQRESG--VLRDKYEKALKAYQAEVDKLRAANEKYA 589
               +     + LR R     A K   +E    + R   +++ +  QAEV+   A+  K  
Sbjct: 1471 AEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--LASRVKAE 1524

Query: 590  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
             E A  K +  QA  E           L   A + ++ L             +Q E+   
Sbjct: 1525 AEAAREKQRALQALEE-----------LRLQAEEAERRL-------------RQAEVERA 1560

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            + V   ++   +     LQ+K     A   ++   L   LQE    +A L+     + + 
Sbjct: 1561 RQVQVALETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            QA   R   +EA+ +    +L+ +E  +L ++    AQ     ++ ++ AE +    E  
Sbjct: 1617 QAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQ-----QKSLAQAEAEKQKEEAE 1670

Query: 770  QRAEAQGKQEVESLREKLLV---AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVE 826
            + A  +GK E +++R++ L     E + Q  E     +     E   +  ET + ++  +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730

Query: 827  GLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSR 886
             L+++L +  +E  A T + + L A+++ + +       +++ LL  K R E E  + S 
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTSE 1783

Query: 887  KTHD----ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIK 942
            K+       +G+   +++E  R       LR L  EA R     E D +R+  +AE  + 
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAAR-------LRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836

Query: 943  EQ--------KLKDDIR-GLREKLTGLDKEKSLSDQRRYS--LIDPSSAPELLRLQHQLM 991
            E+        +LK +    L+EK    ++ + L++   +    ++  +A     ++ +L 
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896

Query: 992  STEDA-----------LRDALDQAQQVEKLMEAMRSCPDKA 1021
                A           + D L Q +QVE+ + A+++  +KA
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 148/681 (21%), Positives = 286/681 (41%), Gaps = 53/681 (7%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLV 421
            ++++Q +E+ LA   L+R E A AT    E+E E+A ++A+ E  +A      + +R   
Sbjct: 1726 EQQRQLLEEELAR--LQR-EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782

Query: 422  ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEK 481
            E  ++     + +  E   +   L+   EE    +   E     + A    +    L   
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842

Query: 482  AQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAE 541
             +A RL  E         AE  R+ +L E+   +R  +EE  Q   H         D  E
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKA-------DIEE 1893

Query: 542  ILRLRERLLSASKEHQRESGVLRD------KYEKALKAYQAEVDKLRAANEKYAQEVAGL 595
              RL +   ++  E +R+ G++ D      + E+ + A +A  +K  A   +   E+  +
Sbjct: 1894 --RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951

Query: 596  KDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEG 655
            +   +  T  +    +   ++   LA++ ++   + +  +     A+++   + KA +E 
Sbjct: 1952 RSNAED-TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010

Query: 656  I-----KMEHQLELGNLQAKHDLETAMHVK-EKEALREKLQEAQEELAGLQRHWRAQLEV 709
            +     K+E   E   L+ + + E+A  ++  +EA +++LQ  ++  A   +    +L+ 
Sbjct: 2011 VERLKAKVE---EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
               Q +  L + + +   A     E E+  V+   +A      + Q+  AE+     E  
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ---SRRQVEEAERLKQSAEEQ 2124

Query: 770  QRAEAQGKQEVESLR-EKLLVAENRLQAVEALCSSQH---THMIESNDISEETIRTKETV 825
             +A AQ +   E LR E    A  R QA +A    +      M +    +E+T+R K  V
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184

Query: 826  E----GLQDKLNKRDKEVTALTSQTEMLRA-------QVSALESKCKSGEKKVDALLKEK 874
            E     L+ +L + D +   L  + + L+A       Q S +E +  S   +++ L K K
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244

Query: 875  RRLEAELETVSRKTHDASGQLVLISQELLRK-ERSLNELRVLLLEANRHSPGPERDLSRE 933
             R+EAE   +  +  D + + +    E +++       L V   EA R     E DL+++
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304

Query: 934  VHKAEWRIKEQ-KLKDDIRGLREKLTGLDKEKSLSDQ--RRYSLIDPSSAPELLRLQHQL 990
               AE  +KE+ +   +   L+ +   L ++K L+ +  RR        A +L       
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364

Query: 991  MSTEDALRD-ALDQAQQVEKL 1010
              T +A R   L+ + + E+L
Sbjct: 2365 QRTLEAERQRQLEMSAEAERL 2385



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 174/781 (22%), Positives = 319/781 (40%), Gaps = 114/781 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L E ++R  R ++     Q  L E+    ++  AER L     A   +   + E EIAL 
Sbjct: 1799 LAEEAARL-RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857

Query: 400  K--AQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---------EEERRK--VEDL- 445
            +  A++E+    AE++  + R L E   + K D+  +L         E ER+K  VED  
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917

Query: 446  -QFRVEEESITKGDLETQTQLEHARIG--ELEQSLLLEKAQAERLLRELADNRLTTVAEK 502
             Q R  EE I    L  +   E A  G  ELE  L   ++ AE  LR      L    E 
Sbjct: 1918 RQRRQVEEEI----LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL----EA 1969

Query: 503  SRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA--EILRLRERLLSASKEHQRES 560
            +R  QL  E   RR E EE  Q  L +         AA  E+ RL+ ++  A +  +R  
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029

Query: 561  GVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSL 620
               ++   +   A +A   +L+A  + +A  V   + ++QQ   +   ++D  + + ++ 
Sbjct: 2030 ---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA- 2085

Query: 621  ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVK 680
            A    +  E+ +          ++++ E + + +  + +        QA+   + A    
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-------AQARAQAQAAAEKL 2138

Query: 681  EKEALREKLQEAQEELAGLQR-------------------HWRAQLEVQASQHRLELQEA 721
             KEA +E  + AQ E A L++                     +AQ+E + +  RL+L+E 
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198

Query: 722  QDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ-RAEAQGK--- 777
              Q+    L   EL++L  E    A+    ++E++     +M +  +L+ R EA+ +   
Sbjct: 2199 DHQKN---LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255

Query: 778  ------------QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT---- 821
                        +E E +++   VAE   +   A   +     +   D++++        
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQ---VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312

Query: 822  KETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL-ESKCKSGEKKVDALLKEKRRLEAE 880
            KE ++ +Q+    +  E   L  Q E+ + Q   L E K +  ++  +     +R LEAE
Sbjct: 2313 KEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371

Query: 881  LETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEW- 939
             +     + +A  +L L   E+ R +    E      +A R     E ++  ++H+ E  
Sbjct: 2372 RQRQLEMSAEAE-RLKLRVAEMSRAQARAEE------DAQRFRKQAE-EIGEKLHRTELA 2423

Query: 940  -----------RIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQH 988
                        I+ Q+   D   LRE +  L++EK    Q    L   S   + ++ Q 
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ-QE 2482

Query: 989  QLMSTEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQED 1044
            QL+    AL+ +     D   Q E+ +E  ++   K + +     A     +++ Q+Q+ 
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQRERFIEQEKA---KLEQLFQDEVAKAQQLREEQQRQQQ 2539

Query: 1045 K 1045
            +
Sbjct: 2540 Q 2540



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 176/744 (23%), Positives = 303/744 (40%), Gaps = 95/744 (12%)

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAE---AEE 412
            ++QE L++ +Q  E   AE   +  +   A      +E+EI +++ Q E    +   AE 
Sbjct: 1417 SIQEELQQLRQSSE---AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473

Query: 413  KLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFR---VEEESITKGDLETQTQLEHAR 469
            +LQ  R   E    +K     + E  RR+V+D   R    E E  ++   E +   E  R
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533

Query: 470  IGELEQSLLLEKAQAERLLR--ELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLL 527
              +  + L L+  +AER LR  E+   R   VA ++     E EL  +R    E    L 
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593

Query: 528  HSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD---KLRAA 584
             S     +H   A++    ER      + Q E+   R++ E+ L+ +Q + +   +LR  
Sbjct: 1594 RS--LQEEHVAVAQLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647

Query: 585  NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQK 644
             E+ AQ+ +  + + ++   E            +      + + ++L+       G  Q+
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707

Query: 645  EIGELKAVMEGIKMEHQLELGNLQAK-HDLETAMHVKEKEALREKLQEAQEELAGLQRHW 703
                L A  E I++  + E G  Q +  + E A   +E  A  +K QE + ELA +    
Sbjct: 1708 ---RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV---- 1760

Query: 704  RAQLEV------QASQHRLELQEAQDQRRDAEL-RVHELEKLDVEYRGQAQAIEFLKEQI 756
            RA++EV      +A +      E   QR +AE  R  EL +     R  A   E  K Q 
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA---EEAKRQR 1817

Query: 757  SLAEKKMLDYERLQRAEAQG---------------KQEVE-SLREKLLVAEN----RLQA 796
             LAE+   D  R QRAEA+                K E E +L+EK   AEN    RL  
Sbjct: 1818 QLAEE---DAAR-QRAEAERVLAEKLAAIGEATRLKTEAEIALKEK--EAENERLRRLAE 1871

Query: 797  VEAL-------CSSQHTHMIES------NDISEETIRTKETVEGLQDKLNKRDKEVTALT 843
             EA         ++QH   IE            E  R K  VE    +  + ++E+ AL 
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931

Query: 844  SQTEMLRAQVSALESKCKSGEKKVDALLKEK----------RRLEAELETVSRKTHDASG 893
            +  E   A  + LE +        +  L+ K          R+L AE E   R+  +   
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991

Query: 894  QLVLISQELLRKERS----LNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDD 949
            + +   +E  R+ ++    +  L+  + EA R     E++ +R++  A+    +++L+ +
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ-EAAQKRLQAE 2050

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDP--SSAPELLRLQHQLMSTE-DALRDALDQAQQ 1006
             +     +   ++E   + Q+  S++D     A    R   +       A R+A    +Q
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 1007 VEKLMEAMRSCPDKAQTIGNSGSA 1030
            VE+     +S  ++AQ    + +A
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAA 2134



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 161/701 (22%), Positives = 287/701 (40%), Gaps = 145/701 (20%)

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEE-ERRKVEDLQFRVEE 451
            E+E       ++Q +   E+  Q        + + K D+  QLE  E R V  L+  +++
Sbjct: 955  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK-DIRLQLEACETRTVHRLRLPLDK 1013

Query: 452  ESITK-GDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEE 510
            E   +      + Q   A +  L + +    A+AE++L       L   +  +  L+ E 
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA------LPEPSPAAPTLRSEL 1067

Query: 511  ELTLRRGEIEELQQC------------LLHSGPPPPDHPDAAEILRLRERLLSASKEHQR 558
            ELTL  G++E+++              L+  G        A E+LR  E  L   KE Q 
Sbjct: 1068 ELTL--GKLEQVRSLSAIYLEKLKTISLVIRGTQ-----GAEEVLRAHEEQL---KEAQA 1117

Query: 559  ESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKD----------KVQQATSENMG 608
                L +     L+A +A + KLRA  E        L+D          ++QQ   E   
Sbjct: 1118 VPATLPE-----LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1172

Query: 609  LMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLE----- 663
             ++ W+ ++  L       LE  +A L +    +Q+E+ +L     G ++ +  E     
Sbjct: 1173 EVERWRERVAQL-------LERWQAVL-AQTDVRQRELEQL-----GRQLRYYRESADPL 1219

Query: 664  ---LGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH------------------ 702
               L + + + +   AM + + +A+RE+L++ Q  L  ++RH                  
Sbjct: 1220 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1279

Query: 703  ---------WRAQLEVQASQHRLELQEAQDQ---RRDAELRVH--ELEKLDVEYRGQAQA 748
                     ++AQLE  AS  +    ++  +   +   +LR H  EL  L  +Y      
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY------ 1333

Query: 749  IEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHM 808
            I+F+ E +    ++M + ERL  AE Q  +E E L E     E + Q  EA   ++    
Sbjct: 1334 IKFISETL----RRMEEEERL--AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387

Query: 809  IESNDI----SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 864
             E+ ++     EE +R +E     Q +     +E+  L   +E   A++ A   + ++ E
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQAEAAE 1444

Query: 865  KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSP 924
            +    + +E R +  +LE   R+   A G+L  +     R E +  + R    EA R   
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR---ARAEEAEAQKRQAQEEAER--- 1498

Query: 925  GPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL 984
                 L R+V     R ++ +++   R   E     +K+++L             A E L
Sbjct: 1499 -----LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL------------QALEEL 1541

Query: 985  RLQHQLMSTEDALRDA-LDQAQQVEKLME-AMRSCPDKAQT 1023
            RLQ +    E  LR A +++A+QV+  +E A RS   + Q+
Sbjct: 1542 RLQAE--EAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 63/262 (24%), Positives = 114/262 (43%), Gaps = 34/262 (12%)

Query: 355  TALQEALKEKQQHIEQ-LLAERD--LERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            T  QE L ++ Q ++Q  L+E+D  L+R            +E+E A L+   +  VA+A+
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERF---------IEQEKAKLEQLFQDEVAKAQ 2528

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
            +  +  +   + + +E+  L   +EE RR+  +      EE + +   E Q QLE  R  
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHE-----AEEGVRRKQEELQ-QLEQQR-R 2581

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVL--QLEEELTLRRGEIEELQQCLLHS 529
            + E+ L  E  +    L+ L +     +A    V   Q+    TL  G  + L       
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR-DAL------D 2634

Query: 530  GPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKL--RAANEK 587
            GP     P+ +    LR ++   S +  +E+G+L  +  + L      VD+L  R     
Sbjct: 2635 GPAAEAEPEHS-FDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2690

Query: 588  YAQEVAGLKDKVQQATSENMGL 609
            Y Q  + +   + +AT+E + +
Sbjct: 2691 YLQGRSSIAGLLLKATNEKLSV 2712


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  108 bits (271), Expect = 2e-23
 Identities = 149/678 (21%), Positives = 285/678 (42%), Gaps = 80/678 (11%)

Query: 325  SVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKE---KQQHIEQLLAERDLERAE 381
            S+A+       R   L E   R   K+     L+E  ++   +Q  + Q  A++ L+  E
Sbjct: 1997 SLAAEEEAARQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2055

Query: 382  VAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRK 441
             A A + + + E+E+     Q +  + +   + + AR   E   + +V    +  + RR+
Sbjct: 2056 KAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114

Query: 442  VED---LQFRVEEESITKGD-------LETQTQLEHARIGELEQSLLLEKAQAERLLREL 491
            VE+   L+   EE++  +         L  + + E AR  + EQ+ L +K  A+  + + 
Sbjct: 2115 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2174

Query: 492  ADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLS 551
                  T+ +K+   Q+E+ELT  R ++EE             DH        L +  L 
Sbjct: 2175 KKFAEQTLRQKA---QVEQELTTLRLQLEET------------DHQK-----NLLDEELQ 2214

Query: 552  ASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGL----KDKVQ---QATS 604
              K    E+   R + E+ L + + ++++L     +   E   L    KD  Q   Q  +
Sbjct: 2215 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2274

Query: 605  ENMGLMDNWKSKLDSLASD----HQKSLEDLKATLNSGPGAQQKEIGE------LKAVME 654
            E M  +    ++L   A +     Q + EDL         AQQ+ + E      ++AV E
Sbjct: 2275 EKMKQVAEEAARLSVAAQEAARLRQLAEEDL---------AQQRALAEKMLKEKMQAVQE 2325

Query: 655  GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA----QLEVQ 710
              +++ + EL  LQ + +L      + +E   +  Q+  EE  G QR   A    QLE+ 
Sbjct: 2326 ATRLKAEAEL--LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2383

Query: 711  ASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA-EKKMLDYERL 769
            A   RL+L+ A+  R  A       E+    +R QA+ I     +  LA ++K+   + L
Sbjct: 2384 AEAERLKLRVAEMSRAQARA-----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2438

Query: 770  QRAEAQGKQEVESLREKLLVAENRLQAVEALCS-----SQHTHMIESNDISEETIRTKET 824
            +    Q   + E LRE +   E   + ++         S+    ++   + +ET   +++
Sbjct: 2439 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2498

Query: 825  VEGLQDKLNKRDKEVTALTSQTEML-RAQVSALESKCKSGEKKVDALLKEKRRLEAELET 883
                +D L +R++ +    ++ E L + +V+  +   +  +++   + +E++RL A +E 
Sbjct: 2499 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2558

Query: 884  VSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE 943
              R+ H+A   +    +EL + E+   +   LL E N+     +  L  E H+A     E
Sbjct: 2559 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLLEEQHRAALAHSE 2617

Query: 944  QKLKDDIRGLREKLTGLD 961
            +     +   +    G D
Sbjct: 2618 EVTASQVAATKTLPNGRD 2635



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 149/701 (21%), Positives = 296/701 (42%), Gaps = 101/701 (14%)

Query: 352  SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            SG+ ++ +   + + H  +L          +++    + E E+     +A+  + +AE E
Sbjct: 1311 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1370

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
              L++ R L E+  + K        +  R+ ++LQ R++EE + + +     Q +   I 
Sbjct: 1371 AALEKQRQLAEAHAQAKA-------QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGP 531
            E E   L + ++AE      A  R    AE+SR L++EEE+ + R ++E  ++     G 
Sbjct: 1424 E-ELQQLRQSSEAE----IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER---QRGG 1474

Query: 532  PPPDHPDAAEILRLRERLLSASKEHQRESG--VLRDKYEKALKAYQAEVDKLRAANEKYA 589
               +     + LR R     A K   +E    + R   +++ +  QAEV+   A+  K  
Sbjct: 1475 AEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--LASRVKAE 1528

Query: 590  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
             E A  K +  QA  E           L   A + ++ L             +Q E+   
Sbjct: 1529 AEAAREKQRALQALEE-----------LRLQAEEAERRL-------------RQAEVERA 1564

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            + V   ++   +     LQ+K     A   ++   L   LQE    +A L+     + + 
Sbjct: 1565 RQVQVALETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1620

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            QA   R   +EA+ +    +L+ +E  +L ++    AQ     ++ ++ AE +    E  
Sbjct: 1621 QAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQ-----QKSLAQAEAEKQKEEAE 1674

Query: 770  QRAEAQGKQEVESLREKLLV---AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVE 826
            + A  +GK E +++R++ L     E + Q  E     +     E   +  ET + ++  +
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734

Query: 827  GLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSR 886
             L+++L +  +E  A T + + L A+++ + +       +++ LL  K R E E  + S 
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTSE 1787

Query: 887  KTHD----ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIK 942
            K+       +G+   +++E  R       LR L  EA R     E D +R+  +AE  + 
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAAR-------LRALAEEAKRQRQLAEEDAARQRAEAERVLA 1840

Query: 943  EQ--------KLKDDIR-GLREKLTGLDKEKSLSDQRRYS--LIDPSSAPELLRLQHQLM 991
            E+        +LK +    L+EK    ++ + L++   +    ++  +A     ++ +L 
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1900

Query: 992  STEDA-----------LRDALDQAQQVEKLMEAMRSCPDKA 1021
                A           + D L Q +QVE+ + A+++  +KA
Sbjct: 1901 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1941



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 148/681 (21%), Positives = 286/681 (41%), Gaps = 53/681 (7%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLV 421
            ++++Q +E+ LA   L+R E A AT    E+E E+A ++A+ E  +A      + +R   
Sbjct: 1730 EQQRQLLEEELAR--LQR-EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1786

Query: 422  ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEK 481
            E  ++     + +  E   +   L+   EE    +   E     + A    +    L   
Sbjct: 1787 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1846

Query: 482  AQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAE 541
             +A RL  E         AE  R+ +L E+   +R  +EE  Q   H         D  E
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKA-------DIEE 1897

Query: 542  ILRLRERLLSASKEHQRESGVLRD------KYEKALKAYQAEVDKLRAANEKYAQEVAGL 595
              RL +   ++  E +R+ G++ D      + E+ + A +A  +K  A   +   E+  +
Sbjct: 1898 --RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955

Query: 596  KDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEG 655
            +   +  T  +    +   ++   LA++ ++   + +  +     A+++   + KA +E 
Sbjct: 1956 RSNAED-TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2014

Query: 656  I-----KMEHQLELGNLQAKHDLETAMHVK-EKEALREKLQEAQEELAGLQRHWRAQLEV 709
            +     K+E   E   L+ + + E+A  ++  +EA +++LQ  ++  A   +    +L+ 
Sbjct: 2015 VERLKAKVE---EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2071

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
               Q +  L + + +   A     E E+  V+   +A      + Q+  AE+     E  
Sbjct: 2072 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ---SRRQVEEAERLKQSAEEQ 2128

Query: 770  QRAEAQGKQEVESLR-EKLLVAENRLQAVEALCSSQH---THMIESNDISEETIRTKETV 825
             +A AQ +   E LR E    A  R QA +A    +      M +    +E+T+R K  V
Sbjct: 2129 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2188

Query: 826  E----GLQDKLNKRDKEVTALTSQTEMLRA-------QVSALESKCKSGEKKVDALLKEK 874
            E     L+ +L + D +   L  + + L+A       Q S +E +  S   +++ L K K
Sbjct: 2189 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2248

Query: 875  RRLEAELETVSRKTHDASGQLVLISQELLRK-ERSLNELRVLLLEANRHSPGPERDLSRE 933
             R+EAE   +  +  D + + +    E +++       L V   EA R     E DL+++
Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308

Query: 934  VHKAEWRIKEQ-KLKDDIRGLREKLTGLDKEKSLSDQ--RRYSLIDPSSAPELLRLQHQL 990
               AE  +KE+ +   +   L+ +   L ++K L+ +  RR        A +L       
Sbjct: 2309 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2368

Query: 991  MSTEDALRD-ALDQAQQVEKL 1010
              T +A R   L+ + + E+L
Sbjct: 2369 QRTLEAERQRQLEMSAEAERL 2389



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 174/781 (22%), Positives = 319/781 (40%), Gaps = 114/781 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L E ++R  R ++     Q  L E+    ++  AER L     A   +   + E EIAL 
Sbjct: 1803 LAEEAARL-RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1861

Query: 400  K--AQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---------EEERRK--VEDL- 445
            +  A++E+    AE++  + R L E   + K D+  +L         E ER+K  VED  
Sbjct: 1862 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1921

Query: 446  -QFRVEEESITKGDLETQTQLEHARIG--ELEQSLLLEKAQAERLLRELADNRLTTVAEK 502
             Q R  EE I    L  +   E A  G  ELE  L   ++ AE  LR      L    E 
Sbjct: 1922 RQRRQVEEEI----LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL----EA 1973

Query: 503  SRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA--EILRLRERLLSASKEHQRES 560
            +R  QL  E   RR E EE  Q  L +         AA  E+ RL+ ++  A +  +R  
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2033

Query: 561  GVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSL 620
               ++   +   A +A   +L+A  + +A  V   + ++QQ   +   ++D  + + ++ 
Sbjct: 2034 ---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA- 2089

Query: 621  ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVK 680
            A    +  E+ +          ++++ E + + +  + +        QA+   + A    
Sbjct: 2090 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-------AQARAQAQAAAEKL 2142

Query: 681  EKEALREKLQEAQEELAGLQR-------------------HWRAQLEVQASQHRLELQEA 721
             KEA +E  + AQ E A L++                     +AQ+E + +  RL+L+E 
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202

Query: 722  QDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ-RAEAQGK--- 777
              Q+    L   EL++L  E    A+    ++E++     +M +  +L+ R EA+ +   
Sbjct: 2203 DHQKN---LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2259

Query: 778  ------------QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT---- 821
                        +E E +++   VAE   +   A   +     +   D++++        
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQ---VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2316

Query: 822  KETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL-ESKCKSGEKKVDALLKEKRRLEAE 880
            KE ++ +Q+    +  E   L  Q E+ + Q   L E K +  ++  +     +R LEAE
Sbjct: 2317 KEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2375

Query: 881  LETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEW- 939
             +     + +A  +L L   E+ R +    E      +A R     E ++  ++H+ E  
Sbjct: 2376 RQRQLEMSAEAE-RLKLRVAEMSRAQARAEE------DAQRFRKQAE-EIGEKLHRTELA 2427

Query: 940  -----------RIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQH 988
                        I+ Q+   D   LRE +  L++EK    Q    L   S   + ++ Q 
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ-QE 2486

Query: 989  QLMSTEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQED 1044
            QL+    AL+ +     D   Q E+ +E  ++   K + +     A     +++ Q+Q+ 
Sbjct: 2487 QLLQETQALQQSFLSEKDSLLQRERFIEQEKA---KLEQLFQDEVAKAQQLREEQQRQQQ 2543

Query: 1045 K 1045
            +
Sbjct: 2544 Q 2544



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 176/744 (23%), Positives = 303/744 (40%), Gaps = 95/744 (12%)

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAE---AEE 412
            ++QE L++ +Q  E   AE   +  +   A      +E+EI +++ Q E    +   AE 
Sbjct: 1421 SIQEELQQLRQSSE---AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1477

Query: 413  KLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFR---VEEESITKGDLETQTQLEHAR 469
            +LQ  R   E    +K     + E  RR+V+D   R    E E  ++   E +   E  R
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1537

Query: 470  IGELEQSLLLEKAQAERLLR--ELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLL 527
              +  + L L+  +AER LR  E+   R   VA ++     E EL  +R    E    L 
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597

Query: 528  HSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD---KLRAA 584
             S     +H   A++    ER      + Q E+   R++ E+ L+ +Q + +   +LR  
Sbjct: 1598 RS--LQEEHVAVAQLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651

Query: 585  NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQK 644
             E+ AQ+ +  + + ++   E            +      + + ++L+       G  Q+
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711

Query: 645  EIGELKAVMEGIKMEHQLELGNLQAK-HDLETAMHVKEKEALREKLQEAQEELAGLQRHW 703
                L A  E I++  + E G  Q +  + E A   +E  A  +K QE + ELA +    
Sbjct: 1712 ---RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV---- 1764

Query: 704  RAQLEV------QASQHRLELQEAQDQRRDAEL-RVHELEKLDVEYRGQAQAIEFLKEQI 756
            RA++EV      +A +      E   QR +AE  R  EL +     R  A   E  K Q 
Sbjct: 1765 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA---EEAKRQR 1821

Query: 757  SLAEKKMLDYERLQRAEAQG---------------KQEVE-SLREKLLVAEN----RLQA 796
             LAE+   D  R QRAEA+                K E E +L+EK   AEN    RL  
Sbjct: 1822 QLAEE---DAAR-QRAEAERVLAEKLAAIGEATRLKTEAEIALKEK--EAENERLRRLAE 1875

Query: 797  VEAL-------CSSQHTHMIES------NDISEETIRTKETVEGLQDKLNKRDKEVTALT 843
             EA         ++QH   IE            E  R K  VE    +  + ++E+ AL 
Sbjct: 1876 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1935

Query: 844  SQTEMLRAQVSALESKCKSGEKKVDALLKEK----------RRLEAELETVSRKTHDASG 893
            +  E   A  + LE +        +  L+ K          R+L AE E   R+  +   
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1995

Query: 894  QLVLISQELLRKERS----LNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDD 949
            + +   +E  R+ ++    +  L+  + EA R     E++ +R++  A+    +++L+ +
Sbjct: 1996 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ-EAAQKRLQAE 2054

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDP--SSAPELLRLQHQLMSTE-DALRDALDQAQQ 1006
             +     +   ++E   + Q+  S++D     A    R   +       A R+A    +Q
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114

Query: 1007 VEKLMEAMRSCPDKAQTIGNSGSA 1030
            VE+     +S  ++AQ    + +A
Sbjct: 2115 VEEAERLKQSAEEQAQARAQAQAA 2138



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 161/701 (22%), Positives = 287/701 (40%), Gaps = 145/701 (20%)

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEE-ERRKVEDLQFRVEE 451
            E+E       ++Q +   E+  Q        + + K D+  QLE  E R V  L+  +++
Sbjct: 959  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK-DIRLQLEACETRTVHRLRLPLDK 1017

Query: 452  ESITK-GDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEE 510
            E   +      + Q   A +  L + +    A+AE++L       L   +  +  L+ E 
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA------LPEPSPAAPTLRSEL 1071

Query: 511  ELTLRRGEIEELQQC------------LLHSGPPPPDHPDAAEILRLRERLLSASKEHQR 558
            ELTL  G++E+++              L+  G        A E+LR  E  L   KE Q 
Sbjct: 1072 ELTL--GKLEQVRSLSAIYLEKLKTISLVIRGTQ-----GAEEVLRAHEEQL---KEAQA 1121

Query: 559  ESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKD----------KVQQATSENMG 608
                L +     L+A +A + KLRA  E        L+D          ++QQ   E   
Sbjct: 1122 VPATLPE-----LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1176

Query: 609  LMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLE----- 663
             ++ W+ ++  L       LE  +A L +    +Q+E+ +L     G ++ +  E     
Sbjct: 1177 EVERWRERVAQL-------LERWQAVL-AQTDVRQRELEQL-----GRQLRYYRESADPL 1223

Query: 664  ---LGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH------------------ 702
               L + + + +   AM + + +A+RE+L++ Q  L  ++RH                  
Sbjct: 1224 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1283

Query: 703  ---------WRAQLEVQASQHRLELQEAQDQ---RRDAELRVH--ELEKLDVEYRGQAQA 748
                     ++AQLE  AS  +    ++  +   +   +LR H  EL  L  +Y      
Sbjct: 1284 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY------ 1337

Query: 749  IEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHM 808
            I+F+ E +    ++M + ERL  AE Q  +E E L E     E + Q  EA   ++    
Sbjct: 1338 IKFISETL----RRMEEEERL--AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1391

Query: 809  IESNDI----SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 864
             E+ ++     EE +R +E     Q +     +E+  L   +E   A++ A   + ++ E
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQAEAAE 1448

Query: 865  KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSP 924
            +    + +E R +  +LE   R+   A G+L  +     R E +  + R    EA R   
Sbjct: 1449 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR---ARAEEAEAQKRQAQEEAER--- 1502

Query: 925  GPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL 984
                 L R+V     R ++ +++   R   E     +K+++L             A E L
Sbjct: 1503 -----LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL------------QALEEL 1545

Query: 985  RLQHQLMSTEDALRDA-LDQAQQVEKLME-AMRSCPDKAQT 1023
            RLQ +    E  LR A +++A+QV+  +E A RS   + Q+
Sbjct: 1546 RLQAE--EAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 63/262 (24%), Positives = 114/262 (43%), Gaps = 34/262 (12%)

Query: 355  TALQEALKEKQQHIEQ-LLAERD--LERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            T  QE L ++ Q ++Q  L+E+D  L+R            +E+E A L+   +  VA+A+
Sbjct: 2482 TVQQEQLLQETQALQQSFLSEKDSLLQRERF---------IEQEKAKLEQLFQDEVAKAQ 2532

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
            +  +  +   + + +E+  L   +EE RR+  +      EE + +   E Q QLE  R  
Sbjct: 2533 QLREEQQRQQQQMEQERQRLVASMEEARRRQHE-----AEEGVRRKQEELQ-QLEQQR-R 2585

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVL--QLEEELTLRRGEIEELQQCLLHS 529
            + E+ L  E  +    L+ L +     +A    V   Q+    TL  G  + L       
Sbjct: 2586 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR-DAL------D 2638

Query: 530  GPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKL--RAANEK 587
            GP     P+ +    LR ++   S +  +E+G+L  +  + L      VD+L  R     
Sbjct: 2639 GPAAEAEPEHS-FDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2694

Query: 588  YAQEVAGLKDKVQQATSENMGL 609
            Y Q  + +   + +AT+E + +
Sbjct: 2695 YLQGRSSIAGLLLKATNEKLSV 2716


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  108 bits (271), Expect = 2e-23
 Identities = 149/678 (21%), Positives = 285/678 (42%), Gaps = 80/678 (11%)

Query: 325  SVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKE---KQQHIEQLLAERDLERAE 381
            S+A+       R   L E   R   K+     L+E  ++   +Q  + Q  A++ L+  E
Sbjct: 1993 SLAAEEEAARQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2051

Query: 382  VAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRK 441
             A A + + + E+E+     Q +  + +   + + AR   E   + +V    +  + RR+
Sbjct: 2052 KAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 442  VED---LQFRVEEESITKGD-------LETQTQLEHARIGELEQSLLLEKAQAERLLREL 491
            VE+   L+   EE++  +         L  + + E AR  + EQ+ L +K  A+  + + 
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2170

Query: 492  ADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLS 551
                  T+ +K+   Q+E+ELT  R ++EE             DH        L +  L 
Sbjct: 2171 KKFAEQTLRQKA---QVEQELTTLRLQLEET------------DHQK-----NLLDEELQ 2210

Query: 552  ASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGL----KDKVQ---QATS 604
              K    E+   R + E+ L + + ++++L     +   E   L    KD  Q   Q  +
Sbjct: 2211 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2270

Query: 605  ENMGLMDNWKSKLDSLASD----HQKSLEDLKATLNSGPGAQQKEIGE------LKAVME 654
            E M  +    ++L   A +     Q + EDL         AQQ+ + E      ++AV E
Sbjct: 2271 EKMKQVAEEAARLSVAAQEAARLRQLAEEDL---------AQQRALAEKMLKEKMQAVQE 2321

Query: 655  GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA----QLEVQ 710
              +++ + EL  LQ + +L      + +E   +  Q+  EE  G QR   A    QLE+ 
Sbjct: 2322 ATRLKAEAEL--LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2379

Query: 711  ASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA-EKKMLDYERL 769
            A   RL+L+ A+  R  A       E+    +R QA+ I     +  LA ++K+   + L
Sbjct: 2380 AEAERLKLRVAEMSRAQARA-----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2434

Query: 770  QRAEAQGKQEVESLREKLLVAENRLQAVEALCS-----SQHTHMIESNDISEETIRTKET 824
            +    Q   + E LRE +   E   + ++         S+    ++   + +ET   +++
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494

Query: 825  VEGLQDKLNKRDKEVTALTSQTEML-RAQVSALESKCKSGEKKVDALLKEKRRLEAELET 883
                +D L +R++ +    ++ E L + +V+  +   +  +++   + +E++RL A +E 
Sbjct: 2495 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2554

Query: 884  VSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE 943
              R+ H+A   +    +EL + E+   +   LL E N+     +  L  E H+A     E
Sbjct: 2555 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLLEEQHRAALAHSE 2613

Query: 944  QKLKDDIRGLREKLTGLD 961
            +     +   +    G D
Sbjct: 2614 EVTASQVAATKTLPNGRD 2631



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 149/701 (21%), Positives = 296/701 (42%), Gaps = 101/701 (14%)

Query: 352  SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            SG+ ++ +   + + H  +L          +++    + E E+     +A+  + +AE E
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
              L++ R L E+  + K        +  R+ ++LQ R++EE + + +     Q +   I 
Sbjct: 1367 AALEKQRQLAEAHAQAKA-------QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGP 531
            E E   L + ++AE      A  R    AE+SR L++EEE+ + R ++E  ++     G 
Sbjct: 1420 E-ELQQLRQSSEAE----IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER---QRGG 1470

Query: 532  PPPDHPDAAEILRLRERLLSASKEHQRESG--VLRDKYEKALKAYQAEVDKLRAANEKYA 589
               +     + LR R     A K   +E    + R   +++ +  QAEV+   A+  K  
Sbjct: 1471 AEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--LASRVKAE 1524

Query: 590  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
             E A  K +  QA  E           L   A + ++ L             +Q E+   
Sbjct: 1525 AEAAREKQRALQALEE-----------LRLQAEEAERRL-------------RQAEVERA 1560

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            + V   ++   +     LQ+K     A   ++   L   LQE    +A L+     + + 
Sbjct: 1561 RQVQVALETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1616

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            QA   R   +EA+ +    +L+ +E  +L ++    AQ     ++ ++ AE +    E  
Sbjct: 1617 QAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQ-----QKSLAQAEAEKQKEEAE 1670

Query: 770  QRAEAQGKQEVESLREKLLV---AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVE 826
            + A  +GK E +++R++ L     E + Q  E     +     E   +  ET + ++  +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730

Query: 827  GLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSR 886
             L+++L +  +E  A T + + L A+++ + +       +++ LL  K R E E  + S 
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTSE 1783

Query: 887  KTHD----ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIK 942
            K+       +G+   +++E  R       LR L  EA R     E D +R+  +AE  + 
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAAR-------LRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836

Query: 943  EQ--------KLKDDIR-GLREKLTGLDKEKSLSDQRRYS--LIDPSSAPELLRLQHQLM 991
            E+        +LK +    L+EK    ++ + L++   +    ++  +A     ++ +L 
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896

Query: 992  STEDA-----------LRDALDQAQQVEKLMEAMRSCPDKA 1021
                A           + D L Q +QVE+ + A+++  +KA
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1937



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 148/681 (21%), Positives = 286/681 (41%), Gaps = 53/681 (7%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLV 421
            ++++Q +E+ LA   L+R E A AT    E+E E+A ++A+ E  +A      + +R   
Sbjct: 1726 EQQRQLLEEELAR--LQR-EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782

Query: 422  ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEK 481
            E  ++     + +  E   +   L+   EE    +   E     + A    +    L   
Sbjct: 1783 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842

Query: 482  AQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAE 541
             +A RL  E         AE  R+ +L E+   +R  +EE  Q   H         D  E
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKA-------DIEE 1893

Query: 542  ILRLRERLLSASKEHQRESGVLRD------KYEKALKAYQAEVDKLRAANEKYAQEVAGL 595
              RL +   ++  E +R+ G++ D      + E+ + A +A  +K  A   +   E+  +
Sbjct: 1894 --RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951

Query: 596  KDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEG 655
            +   +  T  +    +   ++   LA++ ++   + +  +     A+++   + KA +E 
Sbjct: 1952 RSNAED-TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2010

Query: 656  I-----KMEHQLELGNLQAKHDLETAMHVK-EKEALREKLQEAQEELAGLQRHWRAQLEV 709
            +     K+E   E   L+ + + E+A  ++  +EA +++LQ  ++  A   +    +L+ 
Sbjct: 2011 VERLKAKVE---EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2067

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
               Q +  L + + +   A     E E+  V+   +A      + Q+  AE+     E  
Sbjct: 2068 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ---SRRQVEEAERLKQSAEEQ 2124

Query: 770  QRAEAQGKQEVESLR-EKLLVAENRLQAVEALCSSQH---THMIESNDISEETIRTKETV 825
             +A AQ +   E LR E    A  R QA +A    +      M +    +E+T+R K  V
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184

Query: 826  E----GLQDKLNKRDKEVTALTSQTEMLRA-------QVSALESKCKSGEKKVDALLKEK 874
            E     L+ +L + D +   L  + + L+A       Q S +E +  S   +++ L K K
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244

Query: 875  RRLEAELETVSRKTHDASGQLVLISQELLRK-ERSLNELRVLLLEANRHSPGPERDLSRE 933
             R+EAE   +  +  D + + +    E +++       L V   EA R     E DL+++
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304

Query: 934  VHKAEWRIKEQ-KLKDDIRGLREKLTGLDKEKSLSDQ--RRYSLIDPSSAPELLRLQHQL 990
               AE  +KE+ +   +   L+ +   L ++K L+ +  RR        A +L       
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364

Query: 991  MSTEDALRD-ALDQAQQVEKL 1010
              T +A R   L+ + + E+L
Sbjct: 2365 QRTLEAERQRQLEMSAEAERL 2385



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 174/781 (22%), Positives = 319/781 (40%), Gaps = 114/781 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L E ++R  R ++     Q  L E+    ++  AER L     A   +   + E EIAL 
Sbjct: 1799 LAEEAARL-RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1857

Query: 400  K--AQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---------EEERRK--VEDL- 445
            +  A++E+    AE++  + R L E   + K D+  +L         E ER+K  VED  
Sbjct: 1858 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1917

Query: 446  -QFRVEEESITKGDLETQTQLEHARIG--ELEQSLLLEKAQAERLLRELADNRLTTVAEK 502
             Q R  EE I    L  +   E A  G  ELE  L   ++ AE  LR      L    E 
Sbjct: 1918 RQRRQVEEEI----LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL----EA 1969

Query: 503  SRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA--EILRLRERLLSASKEHQRES 560
            +R  QL  E   RR E EE  Q  L +         AA  E+ RL+ ++  A +  +R  
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029

Query: 561  GVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSL 620
               ++   +   A +A   +L+A  + +A  V   + ++QQ   +   ++D  + + ++ 
Sbjct: 2030 ---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA- 2085

Query: 621  ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVK 680
            A    +  E+ +          ++++ E + + +  + +        QA+   + A    
Sbjct: 2086 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-------AQARAQAQAAAEKL 2138

Query: 681  EKEALREKLQEAQEELAGLQR-------------------HWRAQLEVQASQHRLELQEA 721
             KEA +E  + AQ E A L++                     +AQ+E + +  RL+L+E 
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198

Query: 722  QDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ-RAEAQGK--- 777
              Q+    L   EL++L  E    A+    ++E++     +M +  +L+ R EA+ +   
Sbjct: 2199 DHQKN---LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255

Query: 778  ------------QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT---- 821
                        +E E +++   VAE   +   A   +     +   D++++        
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQ---VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312

Query: 822  KETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL-ESKCKSGEKKVDALLKEKRRLEAE 880
            KE ++ +Q+    +  E   L  Q E+ + Q   L E K +  ++  +     +R LEAE
Sbjct: 2313 KEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2371

Query: 881  LETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEW- 939
             +     + +A  +L L   E+ R +    E      +A R     E ++  ++H+ E  
Sbjct: 2372 RQRQLEMSAEAE-RLKLRVAEMSRAQARAEE------DAQRFRKQAE-EIGEKLHRTELA 2423

Query: 940  -----------RIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQH 988
                        I+ Q+   D   LRE +  L++EK    Q    L   S   + ++ Q 
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ-QE 2482

Query: 989  QLMSTEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQED 1044
            QL+    AL+ +     D   Q E+ +E  ++   K + +     A     +++ Q+Q+ 
Sbjct: 2483 QLLQETQALQQSFLSEKDSLLQRERFIEQEKA---KLEQLFQDEVAKAQQLREEQQRQQQ 2539

Query: 1045 K 1045
            +
Sbjct: 2540 Q 2540



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 176/744 (23%), Positives = 303/744 (40%), Gaps = 95/744 (12%)

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAE---AEE 412
            ++QE L++ +Q  E   AE   +  +   A      +E+EI +++ Q E    +   AE 
Sbjct: 1417 SIQEELQQLRQSSE---AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1473

Query: 413  KLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFR---VEEESITKGDLETQTQLEHAR 469
            +LQ  R   E    +K     + E  RR+V+D   R    E E  ++   E +   E  R
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533

Query: 470  IGELEQSLLLEKAQAERLLR--ELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLL 527
              +  + L L+  +AER LR  E+   R   VA ++     E EL  +R    E    L 
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593

Query: 528  HSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD---KLRAA 584
             S     +H   A++    ER      + Q E+   R++ E+ L+ +Q + +   +LR  
Sbjct: 1594 RS--LQEEHVAVAQLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647

Query: 585  NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQK 644
             E+ AQ+ +  + + ++   E            +      + + ++L+       G  Q+
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707

Query: 645  EIGELKAVMEGIKMEHQLELGNLQAK-HDLETAMHVKEKEALREKLQEAQEELAGLQRHW 703
                L A  E I++  + E G  Q +  + E A   +E  A  +K QE + ELA +    
Sbjct: 1708 ---RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV---- 1760

Query: 704  RAQLEV------QASQHRLELQEAQDQRRDAEL-RVHELEKLDVEYRGQAQAIEFLKEQI 756
            RA++EV      +A +      E   QR +AE  R  EL +     R  A   E  K Q 
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA---EEAKRQR 1817

Query: 757  SLAEKKMLDYERLQRAEAQG---------------KQEVE-SLREKLLVAEN----RLQA 796
             LAE+   D  R QRAEA+                K E E +L+EK   AEN    RL  
Sbjct: 1818 QLAEE---DAAR-QRAEAERVLAEKLAAIGEATRLKTEAEIALKEK--EAENERLRRLAE 1871

Query: 797  VEAL-------CSSQHTHMIES------NDISEETIRTKETVEGLQDKLNKRDKEVTALT 843
             EA         ++QH   IE            E  R K  VE    +  + ++E+ AL 
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931

Query: 844  SQTEMLRAQVSALESKCKSGEKKVDALLKEK----------RRLEAELETVSRKTHDASG 893
            +  E   A  + LE +        +  L+ K          R+L AE E   R+  +   
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1991

Query: 894  QLVLISQELLRKERS----LNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDD 949
            + +   +E  R+ ++    +  L+  + EA R     E++ +R++  A+    +++L+ +
Sbjct: 1992 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ-EAAQKRLQAE 2050

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDP--SSAPELLRLQHQLMSTE-DALRDALDQAQQ 1006
             +     +   ++E   + Q+  S++D     A    R   +       A R+A    +Q
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110

Query: 1007 VEKLMEAMRSCPDKAQTIGNSGSA 1030
            VE+     +S  ++AQ    + +A
Sbjct: 2111 VEEAERLKQSAEEQAQARAQAQAA 2134



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 161/701 (22%), Positives = 287/701 (40%), Gaps = 145/701 (20%)

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEE-ERRKVEDLQFRVEE 451
            E+E       ++Q +   E+  Q        + + K D+  QLE  E R V  L+  +++
Sbjct: 955  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK-DIRLQLEACETRTVHRLRLPLDK 1013

Query: 452  ESITK-GDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEE 510
            E   +      + Q   A +  L + +    A+AE++L       L   +  +  L+ E 
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA------LPEPSPAAPTLRSEL 1067

Query: 511  ELTLRRGEIEELQQC------------LLHSGPPPPDHPDAAEILRLRERLLSASKEHQR 558
            ELTL  G++E+++              L+  G        A E+LR  E  L   KE Q 
Sbjct: 1068 ELTL--GKLEQVRSLSAIYLEKLKTISLVIRGTQ-----GAEEVLRAHEEQL---KEAQA 1117

Query: 559  ESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKD----------KVQQATSENMG 608
                L +     L+A +A + KLRA  E        L+D          ++QQ   E   
Sbjct: 1118 VPATLPE-----LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1172

Query: 609  LMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLE----- 663
             ++ W+ ++  L       LE  +A L +    +Q+E+ +L     G ++ +  E     
Sbjct: 1173 EVERWRERVAQL-------LERWQAVL-AQTDVRQRELEQL-----GRQLRYYRESADPL 1219

Query: 664  ---LGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH------------------ 702
               L + + + +   AM + + +A+RE+L++ Q  L  ++RH                  
Sbjct: 1220 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1279

Query: 703  ---------WRAQLEVQASQHRLELQEAQDQ---RRDAELRVH--ELEKLDVEYRGQAQA 748
                     ++AQLE  AS  +    ++  +   +   +LR H  EL  L  +Y      
Sbjct: 1280 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY------ 1333

Query: 749  IEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHM 808
            I+F+ E +    ++M + ERL  AE Q  +E E L E     E + Q  EA   ++    
Sbjct: 1334 IKFISETL----RRMEEEERL--AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387

Query: 809  IESNDI----SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 864
             E+ ++     EE +R +E     Q +     +E+  L   +E   A++ A   + ++ E
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQAEAAE 1444

Query: 865  KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSP 924
            +    + +E R +  +LE   R+   A G+L  +     R E +  + R    EA R   
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR---ARAEEAEAQKRQAQEEAER--- 1498

Query: 925  GPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL 984
                 L R+V     R ++ +++   R   E     +K+++L             A E L
Sbjct: 1499 -----LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL------------QALEEL 1541

Query: 985  RLQHQLMSTEDALRDA-LDQAQQVEKLME-AMRSCPDKAQT 1023
            RLQ +    E  LR A +++A+QV+  +E A RS   + Q+
Sbjct: 1542 RLQAE--EAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 63/262 (24%), Positives = 114/262 (43%), Gaps = 34/262 (12%)

Query: 355  TALQEALKEKQQHIEQ-LLAERD--LERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            T  QE L ++ Q ++Q  L+E+D  L+R            +E+E A L+   +  VA+A+
Sbjct: 2478 TVQQEQLLQETQALQQSFLSEKDSLLQRERF---------IEQEKAKLEQLFQDEVAKAQ 2528

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
            +  +  +   + + +E+  L   +EE RR+  +      EE + +   E Q QLE  R  
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASMEEARRRQHE-----AEEGVRRKQEELQ-QLEQQR-R 2581

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVL--QLEEELTLRRGEIEELQQCLLHS 529
            + E+ L  E  +    L+ L +     +A    V   Q+    TL  G  + L       
Sbjct: 2582 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR-DAL------D 2634

Query: 530  GPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKL--RAANEK 587
            GP     P+ +    LR ++   S +  +E+G+L  +  + L      VD+L  R     
Sbjct: 2635 GPAAEAEPEHS-FDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2690

Query: 588  YAQEVAGLKDKVQQATSENMGL 609
            Y Q  + +   + +AT+E + +
Sbjct: 2691 YLQGRSSIAGLLLKATNEKLSV 2712


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  108 bits (271), Expect = 2e-23
 Identities = 149/678 (21%), Positives = 285/678 (42%), Gaps = 80/678 (11%)

Query: 325  SVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKE---KQQHIEQLLAERDLERAE 381
            S+A+       R   L E   R   K+     L+E  ++   +Q  + Q  A++ L+  E
Sbjct: 1961 SLAAEEEAARQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2019

Query: 382  VAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRK 441
             A A + + + E+E+     Q +  + +   + + AR   E   + +V    +  + RR+
Sbjct: 2020 KAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078

Query: 442  VED---LQFRVEEESITKGD-------LETQTQLEHARIGELEQSLLLEKAQAERLLREL 491
            VE+   L+   EE++  +         L  + + E AR  + EQ+ L +K  A+  + + 
Sbjct: 2079 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2138

Query: 492  ADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLS 551
                  T+ +K+   Q+E+ELT  R ++EE             DH        L +  L 
Sbjct: 2139 KKFAEQTLRQKA---QVEQELTTLRLQLEET------------DHQK-----NLLDEELQ 2178

Query: 552  ASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGL----KDKVQ---QATS 604
              K    E+   R + E+ L + + ++++L     +   E   L    KD  Q   Q  +
Sbjct: 2179 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2238

Query: 605  ENMGLMDNWKSKLDSLASD----HQKSLEDLKATLNSGPGAQQKEIGE------LKAVME 654
            E M  +    ++L   A +     Q + EDL         AQQ+ + E      ++AV E
Sbjct: 2239 EKMKQVAEEAARLSVAAQEAARLRQLAEEDL---------AQQRALAEKMLKEKMQAVQE 2289

Query: 655  GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA----QLEVQ 710
              +++ + EL  LQ + +L      + +E   +  Q+  EE  G QR   A    QLE+ 
Sbjct: 2290 ATRLKAEAEL--LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2347

Query: 711  ASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA-EKKMLDYERL 769
            A   RL+L+ A+  R  A       E+    +R QA+ I     +  LA ++K+   + L
Sbjct: 2348 AEAERLKLRVAEMSRAQARA-----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2402

Query: 770  QRAEAQGKQEVESLREKLLVAENRLQAVEALCS-----SQHTHMIESNDISEETIRTKET 824
            +    Q   + E LRE +   E   + ++         S+    ++   + +ET   +++
Sbjct: 2403 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2462

Query: 825  VEGLQDKLNKRDKEVTALTSQTEML-RAQVSALESKCKSGEKKVDALLKEKRRLEAELET 883
                +D L +R++ +    ++ E L + +V+  +   +  +++   + +E++RL A +E 
Sbjct: 2463 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2522

Query: 884  VSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE 943
              R+ H+A   +    +EL + E+   +   LL E N+     +  L  E H+A     E
Sbjct: 2523 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLLEEQHRAALAHSE 2581

Query: 944  QKLKDDIRGLREKLTGLD 961
            +     +   +    G D
Sbjct: 2582 EVTASQVAATKTLPNGRD 2599



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 149/701 (21%), Positives = 296/701 (42%), Gaps = 101/701 (14%)

Query: 352  SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            SG+ ++ +   + + H  +L          +++    + E E+     +A+  + +AE E
Sbjct: 1275 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1334

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
              L++ R L E+  + K        +  R+ ++LQ R++EE + + +     Q +   I 
Sbjct: 1335 AALEKQRQLAEAHAQAKA-------QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGP 531
            E E   L + ++AE      A  R    AE+SR L++EEE+ + R ++E  ++     G 
Sbjct: 1388 E-ELQQLRQSSEAE----IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER---QRGG 1438

Query: 532  PPPDHPDAAEILRLRERLLSASKEHQRESG--VLRDKYEKALKAYQAEVDKLRAANEKYA 589
               +     + LR R     A K   +E    + R   +++ +  QAEV+   A+  K  
Sbjct: 1439 AEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--LASRVKAE 1492

Query: 590  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
             E A  K +  QA  E           L   A + ++ L             +Q E+   
Sbjct: 1493 AEAAREKQRALQALEE-----------LRLQAEEAERRL-------------RQAEVERA 1528

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            + V   ++   +     LQ+K     A   ++   L   LQE    +A L+     + + 
Sbjct: 1529 RQVQVALETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1584

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            QA   R   +EA+ +    +L+ +E  +L ++    AQ     ++ ++ AE +    E  
Sbjct: 1585 QAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQ-----QKSLAQAEAEKQKEEAE 1638

Query: 770  QRAEAQGKQEVESLREKLLV---AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVE 826
            + A  +GK E +++R++ L     E + Q  E     +     E   +  ET + ++  +
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698

Query: 827  GLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSR 886
             L+++L +  +E  A T + + L A+++ + +       +++ LL  K R E E  + S 
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTSE 1751

Query: 887  KTHD----ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIK 942
            K+       +G+   +++E  R       LR L  EA R     E D +R+  +AE  + 
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAAR-------LRALAEEAKRQRQLAEEDAARQRAEAERVLA 1804

Query: 943  EQ--------KLKDDIR-GLREKLTGLDKEKSLSDQRRYS--LIDPSSAPELLRLQHQLM 991
            E+        +LK +    L+EK    ++ + L++   +    ++  +A     ++ +L 
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1864

Query: 992  STEDA-----------LRDALDQAQQVEKLMEAMRSCPDKA 1021
                A           + D L Q +QVE+ + A+++  +KA
Sbjct: 1865 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1905



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 148/681 (21%), Positives = 286/681 (41%), Gaps = 53/681 (7%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLV 421
            ++++Q +E+ LA   L+R E A AT    E+E E+A ++A+ E  +A      + +R   
Sbjct: 1694 EQQRQLLEEELAR--LQR-EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1750

Query: 422  ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEK 481
            E  ++     + +  E   +   L+   EE    +   E     + A    +    L   
Sbjct: 1751 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1810

Query: 482  AQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAE 541
             +A RL  E         AE  R+ +L E+   +R  +EE  Q   H         D  E
Sbjct: 1811 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKA-------DIEE 1861

Query: 542  ILRLRERLLSASKEHQRESGVLRD------KYEKALKAYQAEVDKLRAANEKYAQEVAGL 595
              RL +   ++  E +R+ G++ D      + E+ + A +A  +K  A   +   E+  +
Sbjct: 1862 --RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919

Query: 596  KDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEG 655
            +   +  T  +    +   ++   LA++ ++   + +  +     A+++   + KA +E 
Sbjct: 1920 RSNAED-TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1978

Query: 656  I-----KMEHQLELGNLQAKHDLETAMHVK-EKEALREKLQEAQEELAGLQRHWRAQLEV 709
            +     K+E   E   L+ + + E+A  ++  +EA +++LQ  ++  A   +    +L+ 
Sbjct: 1979 VERLKAKVE---EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2035

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
               Q +  L + + +   A     E E+  V+   +A      + Q+  AE+     E  
Sbjct: 2036 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ---SRRQVEEAERLKQSAEEQ 2092

Query: 770  QRAEAQGKQEVESLR-EKLLVAENRLQAVEALCSSQH---THMIESNDISEETIRTKETV 825
             +A AQ +   E LR E    A  R QA +A    +      M +    +E+T+R K  V
Sbjct: 2093 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2152

Query: 826  E----GLQDKLNKRDKEVTALTSQTEMLRA-------QVSALESKCKSGEKKVDALLKEK 874
            E     L+ +L + D +   L  + + L+A       Q S +E +  S   +++ L K K
Sbjct: 2153 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2212

Query: 875  RRLEAELETVSRKTHDASGQLVLISQELLRK-ERSLNELRVLLLEANRHSPGPERDLSRE 933
             R+EAE   +  +  D + + +    E +++       L V   EA R     E DL+++
Sbjct: 2213 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2272

Query: 934  VHKAEWRIKEQ-KLKDDIRGLREKLTGLDKEKSLSDQ--RRYSLIDPSSAPELLRLQHQL 990
               AE  +KE+ +   +   L+ +   L ++K L+ +  RR        A +L       
Sbjct: 2273 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2332

Query: 991  MSTEDALRD-ALDQAQQVEKL 1010
              T +A R   L+ + + E+L
Sbjct: 2333 QRTLEAERQRQLEMSAEAERL 2353



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 174/781 (22%), Positives = 319/781 (40%), Gaps = 114/781 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L E ++R  R ++     Q  L E+    ++  AER L     A   +   + E EIAL 
Sbjct: 1767 LAEEAARL-RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1825

Query: 400  K--AQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---------EEERRK--VEDL- 445
            +  A++E+    AE++  + R L E   + K D+  +L         E ER+K  VED  
Sbjct: 1826 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1885

Query: 446  -QFRVEEESITKGDLETQTQLEHARIG--ELEQSLLLEKAQAERLLRELADNRLTTVAEK 502
             Q R  EE I    L  +   E A  G  ELE  L   ++ AE  LR      L    E 
Sbjct: 1886 RQRRQVEEEI----LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL----EA 1937

Query: 503  SRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA--EILRLRERLLSASKEHQRES 560
            +R  QL  E   RR E EE  Q  L +         AA  E+ RL+ ++  A +  +R  
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 1997

Query: 561  GVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSL 620
               ++   +   A +A   +L+A  + +A  V   + ++QQ   +   ++D  + + ++ 
Sbjct: 1998 ---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA- 2053

Query: 621  ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVK 680
            A    +  E+ +          ++++ E + + +  + +        QA+   + A    
Sbjct: 2054 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-------AQARAQAQAAAEKL 2106

Query: 681  EKEALREKLQEAQEELAGLQR-------------------HWRAQLEVQASQHRLELQEA 721
             KEA +E  + AQ E A L++                     +AQ+E + +  RL+L+E 
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166

Query: 722  QDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ-RAEAQGK--- 777
              Q+    L   EL++L  E    A+    ++E++     +M +  +L+ R EA+ +   
Sbjct: 2167 DHQKN---LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2223

Query: 778  ------------QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT---- 821
                        +E E +++   VAE   +   A   +     +   D++++        
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQ---VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2280

Query: 822  KETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL-ESKCKSGEKKVDALLKEKRRLEAE 880
            KE ++ +Q+    +  E   L  Q E+ + Q   L E K +  ++  +     +R LEAE
Sbjct: 2281 KEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2339

Query: 881  LETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEW- 939
             +     + +A  +L L   E+ R +    E      +A R     E ++  ++H+ E  
Sbjct: 2340 RQRQLEMSAEAE-RLKLRVAEMSRAQARAEE------DAQRFRKQAE-EIGEKLHRTELA 2391

Query: 940  -----------RIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQH 988
                        I+ Q+   D   LRE +  L++EK    Q    L   S   + ++ Q 
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ-QE 2450

Query: 989  QLMSTEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQED 1044
            QL+    AL+ +     D   Q E+ +E  ++   K + +     A     +++ Q+Q+ 
Sbjct: 2451 QLLQETQALQQSFLSEKDSLLQRERFIEQEKA---KLEQLFQDEVAKAQQLREEQQRQQQ 2507

Query: 1045 K 1045
            +
Sbjct: 2508 Q 2508



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 176/744 (23%), Positives = 303/744 (40%), Gaps = 95/744 (12%)

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAE---AEE 412
            ++QE L++ +Q  E   AE   +  +   A      +E+EI +++ Q E    +   AE 
Sbjct: 1385 SIQEELQQLRQSSE---AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1441

Query: 413  KLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFR---VEEESITKGDLETQTQLEHAR 469
            +LQ  R   E    +K     + E  RR+V+D   R    E E  ++   E +   E  R
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1501

Query: 470  IGELEQSLLLEKAQAERLLR--ELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLL 527
              +  + L L+  +AER LR  E+   R   VA ++     E EL  +R    E    L 
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561

Query: 528  HSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD---KLRAA 584
             S     +H   A++    ER      + Q E+   R++ E+ L+ +Q + +   +LR  
Sbjct: 1562 RS--LQEEHVAVAQLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615

Query: 585  NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQK 644
             E+ AQ+ +  + + ++   E            +      + + ++L+       G  Q+
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675

Query: 645  EIGELKAVMEGIKMEHQLELGNLQAK-HDLETAMHVKEKEALREKLQEAQEELAGLQRHW 703
                L A  E I++  + E G  Q +  + E A   +E  A  +K QE + ELA +    
Sbjct: 1676 ---RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV---- 1728

Query: 704  RAQLEV------QASQHRLELQEAQDQRRDAEL-RVHELEKLDVEYRGQAQAIEFLKEQI 756
            RA++EV      +A +      E   QR +AE  R  EL +     R  A   E  K Q 
Sbjct: 1729 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA---EEAKRQR 1785

Query: 757  SLAEKKMLDYERLQRAEAQG---------------KQEVE-SLREKLLVAEN----RLQA 796
             LAE+   D  R QRAEA+                K E E +L+EK   AEN    RL  
Sbjct: 1786 QLAEE---DAAR-QRAEAERVLAEKLAAIGEATRLKTEAEIALKEK--EAENERLRRLAE 1839

Query: 797  VEAL-------CSSQHTHMIES------NDISEETIRTKETVEGLQDKLNKRDKEVTALT 843
             EA         ++QH   IE            E  R K  VE    +  + ++E+ AL 
Sbjct: 1840 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1899

Query: 844  SQTEMLRAQVSALESKCKSGEKKVDALLKEK----------RRLEAELETVSRKTHDASG 893
            +  E   A  + LE +        +  L+ K          R+L AE E   R+  +   
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1959

Query: 894  QLVLISQELLRKERS----LNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDD 949
            + +   +E  R+ ++    +  L+  + EA R     E++ +R++  A+    +++L+ +
Sbjct: 1960 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ-EAAQKRLQAE 2018

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDP--SSAPELLRLQHQLMSTE-DALRDALDQAQQ 1006
             +     +   ++E   + Q+  S++D     A    R   +       A R+A    +Q
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078

Query: 1007 VEKLMEAMRSCPDKAQTIGNSGSA 1030
            VE+     +S  ++AQ    + +A
Sbjct: 2079 VEEAERLKQSAEEQAQARAQAQAA 2102



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 161/701 (22%), Positives = 287/701 (40%), Gaps = 145/701 (20%)

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEE-ERRKVEDLQFRVEE 451
            E+E       ++Q +   E+  Q        + + K D+  QLE  E R V  L+  +++
Sbjct: 923  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK-DIRLQLEACETRTVHRLRLPLDK 981

Query: 452  ESITK-GDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEE 510
            E   +      + Q   A +  L + +    A+AE++L       L   +  +  L+ E 
Sbjct: 982  EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA------LPEPSPAAPTLRSEL 1035

Query: 511  ELTLRRGEIEELQQC------------LLHSGPPPPDHPDAAEILRLRERLLSASKEHQR 558
            ELTL  G++E+++              L+  G        A E+LR  E  L   KE Q 
Sbjct: 1036 ELTL--GKLEQVRSLSAIYLEKLKTISLVIRGTQ-----GAEEVLRAHEEQL---KEAQA 1085

Query: 559  ESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKD----------KVQQATSENMG 608
                L +     L+A +A + KLRA  E        L+D          ++QQ   E   
Sbjct: 1086 VPATLPE-----LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1140

Query: 609  LMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLE----- 663
             ++ W+ ++  L       LE  +A L +    +Q+E+ +L     G ++ +  E     
Sbjct: 1141 EVERWRERVAQL-------LERWQAVL-AQTDVRQRELEQL-----GRQLRYYRESADPL 1187

Query: 664  ---LGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH------------------ 702
               L + + + +   AM + + +A+RE+L++ Q  L  ++RH                  
Sbjct: 1188 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1247

Query: 703  ---------WRAQLEVQASQHRLELQEAQDQ---RRDAELRVH--ELEKLDVEYRGQAQA 748
                     ++AQLE  AS  +    ++  +   +   +LR H  EL  L  +Y      
Sbjct: 1248 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY------ 1301

Query: 749  IEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHM 808
            I+F+ E +    ++M + ERL  AE Q  +E E L E     E + Q  EA   ++    
Sbjct: 1302 IKFISETL----RRMEEEERL--AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1355

Query: 809  IESNDI----SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 864
             E+ ++     EE +R +E     Q +     +E+  L   +E   A++ A   + ++ E
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQAEAAE 1412

Query: 865  KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSP 924
            +    + +E R +  +LE   R+   A G+L  +     R E +  + R    EA R   
Sbjct: 1413 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR---ARAEEAEAQKRQAQEEAER--- 1466

Query: 925  GPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL 984
                 L R+V     R ++ +++   R   E     +K+++L             A E L
Sbjct: 1467 -----LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL------------QALEEL 1509

Query: 985  RLQHQLMSTEDALRDA-LDQAQQVEKLME-AMRSCPDKAQT 1023
            RLQ +    E  LR A +++A+QV+  +E A RS   + Q+
Sbjct: 1510 RLQAE--EAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 63/262 (24%), Positives = 114/262 (43%), Gaps = 34/262 (12%)

Query: 355  TALQEALKEKQQHIEQ-LLAERD--LERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            T  QE L ++ Q ++Q  L+E+D  L+R            +E+E A L+   +  VA+A+
Sbjct: 2446 TVQQEQLLQETQALQQSFLSEKDSLLQRERF---------IEQEKAKLEQLFQDEVAKAQ 2496

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
            +  +  +   + + +E+  L   +EE RR+  +      EE + +   E Q QLE  R  
Sbjct: 2497 QLREEQQRQQQQMEQERQRLVASMEEARRRQHE-----AEEGVRRKQEELQ-QLEQQR-R 2549

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVL--QLEEELTLRRGEIEELQQCLLHS 529
            + E+ L  E  +    L+ L +     +A    V   Q+    TL  G  + L       
Sbjct: 2550 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR-DAL------D 2602

Query: 530  GPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKL--RAANEK 587
            GP     P+ +    LR ++   S +  +E+G+L  +  + L      VD+L  R     
Sbjct: 2603 GPAAEAEPEHS-FDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2658

Query: 588  YAQEVAGLKDKVQQATSENMGL 609
            Y Q  + +   + +AT+E + +
Sbjct: 2659 YLQGRSSIAGLLLKATNEKLSV 2680


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  108 bits (271), Expect = 2e-23
 Identities = 149/678 (21%), Positives = 285/678 (42%), Gaps = 80/678 (11%)

Query: 325  SVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKE---KQQHIEQLLAERDLERAE 381
            S+A+       R   L E   R   K+     L+E  ++   +Q  + Q  A++ L+  E
Sbjct: 2130 SLAAEEEAARQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188

Query: 382  VAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRK 441
             A A + + + E+E+     Q +  + +   + + AR   E   + +V    +  + RR+
Sbjct: 2189 KAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247

Query: 442  VED---LQFRVEEESITKGD-------LETQTQLEHARIGELEQSLLLEKAQAERLLREL 491
            VE+   L+   EE++  +         L  + + E AR  + EQ+ L +K  A+  + + 
Sbjct: 2248 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2307

Query: 492  ADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLS 551
                  T+ +K+   Q+E+ELT  R ++EE             DH        L +  L 
Sbjct: 2308 KKFAEQTLRQKA---QVEQELTTLRLQLEET------------DHQK-----NLLDEELQ 2347

Query: 552  ASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGL----KDKVQ---QATS 604
              K    E+   R + E+ L + + ++++L     +   E   L    KD  Q   Q  +
Sbjct: 2348 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2407

Query: 605  ENMGLMDNWKSKLDSLASD----HQKSLEDLKATLNSGPGAQQKEIGE------LKAVME 654
            E M  +    ++L   A +     Q + EDL         AQQ+ + E      ++AV E
Sbjct: 2408 EKMKQVAEEAARLSVAAQEAARLRQLAEEDL---------AQQRALAEKMLKEKMQAVQE 2458

Query: 655  GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA----QLEVQ 710
              +++ + EL  LQ + +L      + +E   +  Q+  EE  G QR   A    QLE+ 
Sbjct: 2459 ATRLKAEAEL--LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2516

Query: 711  ASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA-EKKMLDYERL 769
            A   RL+L+ A+  R  A       E+    +R QA+ I     +  LA ++K+   + L
Sbjct: 2517 AEAERLKLRVAEMSRAQARA-----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2571

Query: 770  QRAEAQGKQEVESLREKLLVAENRLQAVEALCS-----SQHTHMIESNDISEETIRTKET 824
            +    Q   + E LRE +   E   + ++         S+    ++   + +ET   +++
Sbjct: 2572 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2631

Query: 825  VEGLQDKLNKRDKEVTALTSQTEML-RAQVSALESKCKSGEKKVDALLKEKRRLEAELET 883
                +D L +R++ +    ++ E L + +V+  +   +  +++   + +E++RL A +E 
Sbjct: 2632 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2691

Query: 884  VSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE 943
              R+ H+A   +    +EL + E+   +   LL E N+     +  L  E H+A     E
Sbjct: 2692 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLLEEQHRAALAHSE 2750

Query: 944  QKLKDDIRGLREKLTGLD 961
            +     +   +    G D
Sbjct: 2751 EVTASQVAATKTLPNGRD 2768



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 149/701 (21%), Positives = 296/701 (42%), Gaps = 101/701 (14%)

Query: 352  SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            SG+ ++ +   + + H  +L          +++    + E E+     +A+  + +AE E
Sbjct: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
              L++ R L E+  + K        +  R+ ++LQ R++EE + + +     Q +   I 
Sbjct: 1504 AALEKQRQLAEAHAQAKA-------QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGP 531
            E E   L + ++AE      A  R    AE+SR L++EEE+ + R ++E  ++     G 
Sbjct: 1557 E-ELQQLRQSSEAE----IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER---QRGG 1607

Query: 532  PPPDHPDAAEILRLRERLLSASKEHQRESG--VLRDKYEKALKAYQAEVDKLRAANEKYA 589
               +     + LR R     A K   +E    + R   +++ +  QAEV+   A+  K  
Sbjct: 1608 AEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--LASRVKAE 1661

Query: 590  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
             E A  K +  QA  E           L   A + ++ L             +Q E+   
Sbjct: 1662 AEAAREKQRALQALEE-----------LRLQAEEAERRL-------------RQAEVERA 1697

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            + V   ++   +     LQ+K     A   ++   L   LQE    +A L+     + + 
Sbjct: 1698 RQVQVALETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            QA   R   +EA+ +    +L+ +E  +L ++    AQ     ++ ++ AE +    E  
Sbjct: 1754 QAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQ-----QKSLAQAEAEKQKEEAE 1807

Query: 770  QRAEAQGKQEVESLREKLLV---AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVE 826
            + A  +GK E +++R++ L     E + Q  E     +     E   +  ET + ++  +
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867

Query: 827  GLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSR 886
             L+++L +  +E  A T + + L A+++ + +       +++ LL  K R E E  + S 
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTSE 1920

Query: 887  KTHD----ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIK 942
            K+       +G+   +++E  R       LR L  EA R     E D +R+  +AE  + 
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAAR-------LRALAEEAKRQRQLAEEDAARQRAEAERVLA 1973

Query: 943  EQ--------KLKDDIR-GLREKLTGLDKEKSLSDQRRYS--LIDPSSAPELLRLQHQLM 991
            E+        +LK +    L+EK    ++ + L++   +    ++  +A     ++ +L 
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 2033

Query: 992  STEDA-----------LRDALDQAQQVEKLMEAMRSCPDKA 1021
                A           + D L Q +QVE+ + A+++  +KA
Sbjct: 2034 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 148/681 (21%), Positives = 286/681 (41%), Gaps = 53/681 (7%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLV 421
            ++++Q +E+ LA   L+R E A AT    E+E E+A ++A+ E  +A      + +R   
Sbjct: 1863 EQQRQLLEEELAR--LQR-EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1919

Query: 422  ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEK 481
            E  ++     + +  E   +   L+   EE    +   E     + A    +    L   
Sbjct: 1920 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1979

Query: 482  AQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAE 541
             +A RL  E         AE  R+ +L E+   +R  +EE  Q   H         D  E
Sbjct: 1980 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKA-------DIEE 2030

Query: 542  ILRLRERLLSASKEHQRESGVLRD------KYEKALKAYQAEVDKLRAANEKYAQEVAGL 595
              RL +   ++  E +R+ G++ D      + E+ + A +A  +K  A   +   E+  +
Sbjct: 2031 --RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088

Query: 596  KDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEG 655
            +   +  T  +    +   ++   LA++ ++   + +  +     A+++   + KA +E 
Sbjct: 2089 RSNAED-TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2147

Query: 656  I-----KMEHQLELGNLQAKHDLETAMHVK-EKEALREKLQEAQEELAGLQRHWRAQLEV 709
            +     K+E   E   L+ + + E+A  ++  +EA +++LQ  ++  A   +    +L+ 
Sbjct: 2148 VERLKAKVE---EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2204

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
               Q +  L + + +   A     E E+  V+   +A      + Q+  AE+     E  
Sbjct: 2205 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ---SRRQVEEAERLKQSAEEQ 2261

Query: 770  QRAEAQGKQEVESLR-EKLLVAENRLQAVEALCSSQH---THMIESNDISEETIRTKETV 825
             +A AQ +   E LR E    A  R QA +A    +      M +    +E+T+R K  V
Sbjct: 2262 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2321

Query: 826  E----GLQDKLNKRDKEVTALTSQTEMLRA-------QVSALESKCKSGEKKVDALLKEK 874
            E     L+ +L + D +   L  + + L+A       Q S +E +  S   +++ L K K
Sbjct: 2322 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2381

Query: 875  RRLEAELETVSRKTHDASGQLVLISQELLRK-ERSLNELRVLLLEANRHSPGPERDLSRE 933
             R+EAE   +  +  D + + +    E +++       L V   EA R     E DL+++
Sbjct: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441

Query: 934  VHKAEWRIKEQ-KLKDDIRGLREKLTGLDKEKSLSDQ--RRYSLIDPSSAPELLRLQHQL 990
               AE  +KE+ +   +   L+ +   L ++K L+ +  RR        A +L       
Sbjct: 2442 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2501

Query: 991  MSTEDALRD-ALDQAQQVEKL 1010
              T +A R   L+ + + E+L
Sbjct: 2502 QRTLEAERQRQLEMSAEAERL 2522



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 174/781 (22%), Positives = 319/781 (40%), Gaps = 114/781 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L E ++R  R ++     Q  L E+    ++  AER L     A   +   + E EIAL 
Sbjct: 1936 LAEEAARL-RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1994

Query: 400  K--AQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---------EEERRK--VEDL- 445
            +  A++E+    AE++  + R L E   + K D+  +L         E ER+K  VED  
Sbjct: 1995 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 2054

Query: 446  -QFRVEEESITKGDLETQTQLEHARIG--ELEQSLLLEKAQAERLLRELADNRLTTVAEK 502
             Q R  EE I    L  +   E A  G  ELE  L   ++ AE  LR      L    E 
Sbjct: 2055 RQRRQVEEEI----LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL----EA 2106

Query: 503  SRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA--EILRLRERLLSASKEHQRES 560
            +R  QL  E   RR E EE  Q  L +         AA  E+ RL+ ++  A +  +R  
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2166

Query: 561  GVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSL 620
               ++   +   A +A   +L+A  + +A  V   + ++QQ   +   ++D  + + ++ 
Sbjct: 2167 ---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA- 2222

Query: 621  ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVK 680
            A    +  E+ +          ++++ E + + +  + +        QA+   + A    
Sbjct: 2223 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-------AQARAQAQAAAEKL 2275

Query: 681  EKEALREKLQEAQEELAGLQR-------------------HWRAQLEVQASQHRLELQEA 721
             KEA +E  + AQ E A L++                     +AQ+E + +  RL+L+E 
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335

Query: 722  QDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ-RAEAQGK--- 777
              Q+    L   EL++L  E    A+    ++E++     +M +  +L+ R EA+ +   
Sbjct: 2336 DHQKN---LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2392

Query: 778  ------------QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT---- 821
                        +E E +++   VAE   +   A   +     +   D++++        
Sbjct: 2393 LRDKDNTQRFLQEEAEKMKQ---VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2449

Query: 822  KETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL-ESKCKSGEKKVDALLKEKRRLEAE 880
            KE ++ +Q+    +  E   L  Q E+ + Q   L E K +  ++  +     +R LEAE
Sbjct: 2450 KEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2508

Query: 881  LETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEW- 939
             +     + +A  +L L   E+ R +    E      +A R     E ++  ++H+ E  
Sbjct: 2509 RQRQLEMSAEAE-RLKLRVAEMSRAQARAEE------DAQRFRKQAE-EIGEKLHRTELA 2560

Query: 940  -----------RIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQH 988
                        I+ Q+   D   LRE +  L++EK    Q    L   S   + ++ Q 
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ-QE 2619

Query: 989  QLMSTEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQED 1044
            QL+    AL+ +     D   Q E+ +E  ++   K + +     A     +++ Q+Q+ 
Sbjct: 2620 QLLQETQALQQSFLSEKDSLLQRERFIEQEKA---KLEQLFQDEVAKAQQLREEQQRQQQ 2676

Query: 1045 K 1045
            +
Sbjct: 2677 Q 2677



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 176/744 (23%), Positives = 303/744 (40%), Gaps = 95/744 (12%)

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAE---AEE 412
            ++QE L++ +Q  E   AE   +  +   A      +E+EI +++ Q E    +   AE 
Sbjct: 1554 SIQEELQQLRQSSE---AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1610

Query: 413  KLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFR---VEEESITKGDLETQTQLEHAR 469
            +LQ  R   E    +K     + E  RR+V+D   R    E E  ++   E +   E  R
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1670

Query: 470  IGELEQSLLLEKAQAERLLR--ELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLL 527
              +  + L L+  +AER LR  E+   R   VA ++     E EL  +R    E    L 
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730

Query: 528  HSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD---KLRAA 584
             S     +H   A++    ER      + Q E+   R++ E+ L+ +Q + +   +LR  
Sbjct: 1731 RS--LQEEHVAVAQLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784

Query: 585  NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQK 644
             E+ AQ+ +  + + ++   E            +      + + ++L+       G  Q+
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844

Query: 645  EIGELKAVMEGIKMEHQLELGNLQAK-HDLETAMHVKEKEALREKLQEAQEELAGLQRHW 703
                L A  E I++  + E G  Q +  + E A   +E  A  +K QE + ELA +    
Sbjct: 1845 ---RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV---- 1897

Query: 704  RAQLEV------QASQHRLELQEAQDQRRDAEL-RVHELEKLDVEYRGQAQAIEFLKEQI 756
            RA++EV      +A +      E   QR +AE  R  EL +     R  A   E  K Q 
Sbjct: 1898 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA---EEAKRQR 1954

Query: 757  SLAEKKMLDYERLQRAEAQG---------------KQEVE-SLREKLLVAEN----RLQA 796
             LAE+   D  R QRAEA+                K E E +L+EK   AEN    RL  
Sbjct: 1955 QLAEE---DAAR-QRAEAERVLAEKLAAIGEATRLKTEAEIALKEK--EAENERLRRLAE 2008

Query: 797  VEAL-------CSSQHTHMIES------NDISEETIRTKETVEGLQDKLNKRDKEVTALT 843
             EA         ++QH   IE            E  R K  VE    +  + ++E+ AL 
Sbjct: 2009 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 2068

Query: 844  SQTEMLRAQVSALESKCKSGEKKVDALLKEK----------RRLEAELETVSRKTHDASG 893
            +  E   A  + LE +        +  L+ K          R+L AE E   R+  +   
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 2128

Query: 894  QLVLISQELLRKERS----LNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDD 949
            + +   +E  R+ ++    +  L+  + EA R     E++ +R++  A+    +++L+ +
Sbjct: 2129 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ-EAAQKRLQAE 2187

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDP--SSAPELLRLQHQLMSTE-DALRDALDQAQQ 1006
             +     +   ++E   + Q+  S++D     A    R   +       A R+A    +Q
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247

Query: 1007 VEKLMEAMRSCPDKAQTIGNSGSA 1030
            VE+     +S  ++AQ    + +A
Sbjct: 2248 VEEAERLKQSAEEQAQARAQAQAA 2271



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 161/701 (22%), Positives = 287/701 (40%), Gaps = 145/701 (20%)

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEE-ERRKVEDLQFRVEE 451
            E+E       ++Q +   E+  Q        + + K D+  QLE  E R V  L+  +++
Sbjct: 1092 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK-DIRLQLEACETRTVHRLRLPLDK 1150

Query: 452  ESITK-GDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEE 510
            E   +      + Q   A +  L + +    A+AE++L       L   +  +  L+ E 
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA------LPEPSPAAPTLRSEL 1204

Query: 511  ELTLRRGEIEELQQC------------LLHSGPPPPDHPDAAEILRLRERLLSASKEHQR 558
            ELTL  G++E+++              L+  G        A E+LR  E  L   KE Q 
Sbjct: 1205 ELTL--GKLEQVRSLSAIYLEKLKTISLVIRGTQ-----GAEEVLRAHEEQL---KEAQA 1254

Query: 559  ESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKD----------KVQQATSENMG 608
                L +     L+A +A + KLRA  E        L+D          ++QQ   E   
Sbjct: 1255 VPATLPE-----LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1309

Query: 609  LMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLE----- 663
             ++ W+ ++  L       LE  +A L +    +Q+E+ +L     G ++ +  E     
Sbjct: 1310 EVERWRERVAQL-------LERWQAVL-AQTDVRQRELEQL-----GRQLRYYRESADPL 1356

Query: 664  ---LGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH------------------ 702
               L + + + +   AM + + +A+RE+L++ Q  L  ++RH                  
Sbjct: 1357 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1416

Query: 703  ---------WRAQLEVQASQHRLELQEAQDQ---RRDAELRVH--ELEKLDVEYRGQAQA 748
                     ++AQLE  AS  +    ++  +   +   +LR H  EL  L  +Y      
Sbjct: 1417 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY------ 1470

Query: 749  IEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHM 808
            I+F+ E +    ++M + ERL  AE Q  +E E L E     E + Q  EA   ++    
Sbjct: 1471 IKFISETL----RRMEEEERL--AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1524

Query: 809  IESNDI----SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 864
             E+ ++     EE +R +E     Q +     +E+  L   +E   A++ A   + ++ E
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQAEAAE 1581

Query: 865  KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSP 924
            +    + +E R +  +LE   R+   A G+L  +     R E +  + R    EA R   
Sbjct: 1582 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR---ARAEEAEAQKRQAQEEAER--- 1635

Query: 925  GPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL 984
                 L R+V     R ++ +++   R   E     +K+++L             A E L
Sbjct: 1636 -----LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL------------QALEEL 1678

Query: 985  RLQHQLMSTEDALRDA-LDQAQQVEKLME-AMRSCPDKAQT 1023
            RLQ +    E  LR A +++A+QV+  +E A RS   + Q+
Sbjct: 1679 RLQAE--EAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 63/262 (24%), Positives = 114/262 (43%), Gaps = 34/262 (12%)

Query: 355  TALQEALKEKQQHIEQ-LLAERD--LERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            T  QE L ++ Q ++Q  L+E+D  L+R            +E+E A L+   +  VA+A+
Sbjct: 2615 TVQQEQLLQETQALQQSFLSEKDSLLQRERF---------IEQEKAKLEQLFQDEVAKAQ 2665

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
            +  +  +   + + +E+  L   +EE RR+  +      EE + +   E Q QLE  R  
Sbjct: 2666 QLREEQQRQQQQMEQERQRLVASMEEARRRQHE-----AEEGVRRKQEELQ-QLEQQR-R 2718

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVL--QLEEELTLRRGEIEELQQCLLHS 529
            + E+ L  E  +    L+ L +     +A    V   Q+    TL  G  + L       
Sbjct: 2719 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR-DAL------D 2771

Query: 530  GPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKL--RAANEK 587
            GP     P+ +    LR ++   S +  +E+G+L  +  + L      VD+L  R     
Sbjct: 2772 GPAAEAEPEHS-FDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2827

Query: 588  YAQEVAGLKDKVQQATSENMGL 609
            Y Q  + +   + +AT+E + +
Sbjct: 2828 YLQGRSSIAGLLLKATNEKLSV 2849


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  108 bits (271), Expect = 2e-23
 Identities = 149/678 (21%), Positives = 285/678 (42%), Gaps = 80/678 (11%)

Query: 325  SVASSVGGRPSRSGLLTETSSRYARKISGTTALQEALKE---KQQHIEQLLAERDLERAE 381
            S+A+       R   L E   R   K+     L+E  ++   +Q  + Q  A++ L+  E
Sbjct: 1971 SLAAEEEAARQRKAALEEVE-RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029

Query: 382  VAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRK 441
             A A + + + E+E+     Q +  + +   + + AR   E   + +V    +  + RR+
Sbjct: 2030 KAHAFA-VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088

Query: 442  VED---LQFRVEEESITKGD-------LETQTQLEHARIGELEQSLLLEKAQAERLLREL 491
            VE+   L+   EE++  +         L  + + E AR  + EQ+ L +K  A+  + + 
Sbjct: 2089 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2148

Query: 492  ADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLS 551
                  T+ +K+   Q+E+ELT  R ++EE             DH        L +  L 
Sbjct: 2149 KKFAEQTLRQKA---QVEQELTTLRLQLEET------------DHQK-----NLLDEELQ 2188

Query: 552  ASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGL----KDKVQ---QATS 604
              K    E+   R + E+ L + + ++++L     +   E   L    KD  Q   Q  +
Sbjct: 2189 RLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEA 2248

Query: 605  ENMGLMDNWKSKLDSLASD----HQKSLEDLKATLNSGPGAQQKEIGE------LKAVME 654
            E M  +    ++L   A +     Q + EDL         AQQ+ + E      ++AV E
Sbjct: 2249 EKMKQVAEEAARLSVAAQEAARLRQLAEEDL---------AQQRALAEKMLKEKMQAVQE 2299

Query: 655  GIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRA----QLEVQ 710
              +++ + EL  LQ + +L      + +E   +  Q+  EE  G QR   A    QLE+ 
Sbjct: 2300 ATRLKAEAEL--LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMS 2357

Query: 711  ASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA-EKKMLDYERL 769
            A   RL+L+ A+  R  A       E+    +R QA+ I     +  LA ++K+   + L
Sbjct: 2358 AEAERLKLRVAEMSRAQARA-----EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL 2412

Query: 770  QRAEAQGKQEVESLREKLLVAENRLQAVEALCS-----SQHTHMIESNDISEETIRTKET 824
            +    Q   + E LRE +   E   + ++         S+    ++   + +ET   +++
Sbjct: 2413 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2472

Query: 825  VEGLQDKLNKRDKEVTALTSQTEML-RAQVSALESKCKSGEKKVDALLKEKRRLEAELET 883
                +D L +R++ +    ++ E L + +V+  +   +  +++   + +E++RL A +E 
Sbjct: 2473 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE 2532

Query: 884  VSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE 943
              R+ H+A   +    +EL + E+   +   LL E N+     +  L  E H+A     E
Sbjct: 2533 ARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL-REQLQLLEEQHRAALAHSE 2591

Query: 944  QKLKDDIRGLREKLTGLD 961
            +     +   +    G D
Sbjct: 2592 EVTASQVAATKTLPNGRD 2609



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 149/701 (21%), Positives = 296/701 (42%), Gaps = 101/701 (14%)

Query: 352  SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            SG+ ++ +   + + H  +L          +++    + E E+     +A+  + +AE E
Sbjct: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
              L++ R L E+  + K        +  R+ ++LQ R++EE + + +     Q +   I 
Sbjct: 1345 AALEKQRQLAEAHAQAKA-------QAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGP 531
            E E   L + ++AE      A  R    AE+SR L++EEE+ + R ++E  ++     G 
Sbjct: 1398 E-ELQQLRQSSEAE----IQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER---QRGG 1448

Query: 532  PPPDHPDAAEILRLRERLLSASKEHQRESG--VLRDKYEKALKAYQAEVDKLRAANEKYA 589
               +     + LR R     A K   +E    + R   +++ +  QAEV+   A+  K  
Sbjct: 1449 AEGE----LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE--LASRVKAE 1502

Query: 590  QEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGEL 649
             E A  K +  QA  E           L   A + ++ L             +Q E+   
Sbjct: 1503 AEAAREKQRALQALEE-----------LRLQAEEAERRL-------------RQAEVERA 1538

Query: 650  KAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEV 709
            + V   ++   +     LQ+K     A   ++   L   LQE    +A L+     + + 
Sbjct: 1539 RQVQVALETAQRSAEAELQSKR----ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
            QA   R   +EA+ +    +L+ +E  +L ++    AQ     ++ ++ AE +    E  
Sbjct: 1595 QAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQ-----QKSLAQAEAEKQKEEAE 1648

Query: 770  QRAEAQGKQEVESLREKLLV---AENRLQAVEALCSSQHTHMIESNDISEETIRTKETVE 826
            + A  +GK E +++R++ L     E + Q  E     +     E   +  ET + ++  +
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708

Query: 827  GLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSR 886
             L+++L +  +E  A T + + L A+++ + +       +++ LL  K R E E  + S 
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRA-------EMEVLLASKARAEEESRSTSE 1761

Query: 887  KTHD----ASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIK 942
            K+       +G+   +++E  R       LR L  EA R     E D +R+  +AE  + 
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAAR-------LRALAEEAKRQRQLAEEDAARQRAEAERVLA 1814

Query: 943  EQ--------KLKDDIR-GLREKLTGLDKEKSLSDQRRYS--LIDPSSAPELLRLQHQLM 991
            E+        +LK +    L+EK    ++ + L++   +    ++  +A     ++ +L 
Sbjct: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874

Query: 992  STEDA-----------LRDALDQAQQVEKLMEAMRSCPDKA 1021
                A           + D L Q +QVE+ + A+++  +KA
Sbjct: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915



 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 148/681 (21%), Positives = 286/681 (41%), Gaps = 53/681 (7%)

Query: 362  KEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRARLLV 421
            ++++Q +E+ LA   L+R E A AT    E+E E+A ++A+ E  +A      + +R   
Sbjct: 1704 EQQRQLLEEELAR--LQR-EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1760

Query: 422  ESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQSLLLEK 481
            E  ++     + +  E   +   L+   EE    +   E     + A    +    L   
Sbjct: 1761 EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAI 1820

Query: 482  AQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAE 541
             +A RL  E         AE  R+ +L E+   +R  +EE  Q   H         D  E
Sbjct: 1821 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE--QAAQHKA-------DIEE 1871

Query: 542  ILRLRERLLSASKEHQRESGVLRD------KYEKALKAYQAEVDKLRAANEKYAQEVAGL 595
              RL +   ++  E +R+ G++ D      + E+ + A +A  +K  A   +   E+  +
Sbjct: 1872 --RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929

Query: 596  KDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEG 655
            +   +  T  +    +   ++   LA++ ++   + +  +     A+++   + KA +E 
Sbjct: 1930 RSNAED-TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1988

Query: 656  I-----KMEHQLELGNLQAKHDLETAMHVK-EKEALREKLQEAQEELAGLQRHWRAQLEV 709
            +     K+E   E   L+ + + E+A  ++  +EA +++LQ  ++  A   +    +L+ 
Sbjct: 1989 VERLKAKVE---EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQ 2045

Query: 710  QASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERL 769
               Q +  L + + +   A     E E+  V+   +A      + Q+  AE+     E  
Sbjct: 2046 TLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQ---SRRQVEEAERLKQSAEEQ 2102

Query: 770  QRAEAQGKQEVESLR-EKLLVAENRLQAVEALCSSQH---THMIESNDISEETIRTKETV 825
             +A AQ +   E LR E    A  R QA +A    +      M +    +E+T+R K  V
Sbjct: 2103 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2162

Query: 826  E----GLQDKLNKRDKEVTALTSQTEMLRA-------QVSALESKCKSGEKKVDALLKEK 874
            E     L+ +L + D +   L  + + L+A       Q S +E +  S   +++ L K K
Sbjct: 2163 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2222

Query: 875  RRLEAELETVSRKTHDASGQLVLISQELLRK-ERSLNELRVLLLEANRHSPGPERDLSRE 933
             R+EAE   +  +  D + + +    E +++       L V   EA R     E DL+++
Sbjct: 2223 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282

Query: 934  VHKAEWRIKEQ-KLKDDIRGLREKLTGLDKEKSLSDQ--RRYSLIDPSSAPELLRLQHQL 990
               AE  +KE+ +   +   L+ +   L ++K L+ +  RR        A +L       
Sbjct: 2283 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2342

Query: 991  MSTEDALRD-ALDQAQQVEKL 1010
              T +A R   L+ + + E+L
Sbjct: 2343 QRTLEAERQRQLEMSAEAERL 2363



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 174/781 (22%), Positives = 319/781 (40%), Gaps = 114/781 (14%)

Query: 340  LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALL 399
            L E ++R  R ++     Q  L E+    ++  AER L     A   +   + E EIAL 
Sbjct: 1777 LAEEAARL-RALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALK 1835

Query: 400  K--AQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQL---------EEERRK--VEDL- 445
            +  A++E+    AE++  + R L E   + K D+  +L         E ER+K  VED  
Sbjct: 1836 EKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTL 1895

Query: 446  -QFRVEEESITKGDLETQTQLEHARIG--ELEQSLLLEKAQAERLLRELADNRLTTVAEK 502
             Q R  EE I    L  +   E A  G  ELE  L   ++ AE  LR      L    E 
Sbjct: 1896 RQRRQVEEEI----LALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL----EA 1947

Query: 503  SRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAA--EILRLRERLLSASKEHQRES 560
            +R  QL  E   RR E EE  Q  L +         AA  E+ RL+ ++  A +  +R  
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2007

Query: 561  GVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSL 620
               ++   +   A +A   +L+A  + +A  V   + ++QQ   +   ++D  + + ++ 
Sbjct: 2008 ---QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEA- 2063

Query: 621  ASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVK 680
            A    +  E+ +          ++++ E + + +  + +        QA+   + A    
Sbjct: 2064 ARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-------AQARAQAQAAAEKL 2116

Query: 681  EKEALREKLQEAQEELAGLQR-------------------HWRAQLEVQASQHRLELQEA 721
             KEA +E  + AQ E A L++                     +AQ+E + +  RL+L+E 
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176

Query: 722  QDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQ-RAEAQGK--- 777
              Q+    L   EL++L  E    A+    ++E++     +M +  +L+ R EA+ +   
Sbjct: 2177 DHQKN---LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233

Query: 778  ------------QEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRT---- 821
                        +E E +++   VAE   +   A   +     +   D++++        
Sbjct: 2234 LRDKDNTQRFLQEEAEKMKQ---VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2290

Query: 822  KETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSAL-ESKCKSGEKKVDALLKEKRRLEAE 880
            KE ++ +Q+    +  E   L  Q E+ + Q   L E K +  ++  +     +R LEAE
Sbjct: 2291 KEKMQAVQEATRLK-AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAE 2349

Query: 881  LETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEW- 939
             +     + +A  +L L   E+ R +    E      +A R     E ++  ++H+ E  
Sbjct: 2350 RQRQLEMSAEAE-RLKLRVAEMSRAQARAEE------DAQRFRKQAE-EIGEKLHRTELA 2401

Query: 940  -----------RIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELLRLQH 988
                        I+ Q+   D   LRE +  L++EK    Q    L   S   + ++ Q 
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ-QE 2460

Query: 989  QLMSTEDALRDAL----DQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQED 1044
            QL+    AL+ +     D   Q E+ +E  ++   K + +     A     +++ Q+Q+ 
Sbjct: 2461 QLLQETQALQQSFLSEKDSLLQRERFIEQEKA---KLEQLFQDEVAKAQQLREEQQRQQQ 2517

Query: 1045 K 1045
            +
Sbjct: 2518 Q 2518



 Score = 87.8 bits (216), Expect = 5e-17
 Identities = 176/744 (23%), Positives = 303/744 (40%), Gaps = 95/744 (12%)

Query: 356  ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAE---AEE 412
            ++QE L++ +Q  E   AE   +  +   A      +E+EI +++ Q E    +   AE 
Sbjct: 1395 SIQEELQQLRQSSE---AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEG 1451

Query: 413  KLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFR---VEEESITKGDLETQTQLEHAR 469
            +LQ  R   E    +K     + E  RR+V+D   R    E E  ++   E +   E  R
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1511

Query: 470  IGELEQSLLLEKAQAERLLR--ELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLL 527
              +  + L L+  +AER LR  E+   R   VA ++     E EL  +R    E    L 
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571

Query: 528  HSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD---KLRAA 584
             S     +H   A++    ER      + Q E+   R++ E+ L+ +Q + +   +LR  
Sbjct: 1572 RS--LQEEHVAVAQLREEAER----RAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625

Query: 585  NEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQK 644
             E+ AQ+ +  + + ++   E            +      + + ++L+       G  Q+
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685

Query: 645  EIGELKAVMEGIKMEHQLELGNLQAK-HDLETAMHVKEKEALREKLQEAQEELAGLQRHW 703
                L A  E I++  + E G  Q +  + E A   +E  A  +K QE + ELA +    
Sbjct: 1686 ---RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV---- 1738

Query: 704  RAQLEV------QASQHRLELQEAQDQRRDAEL-RVHELEKLDVEYRGQAQAIEFLKEQI 756
            RA++EV      +A +      E   QR +AE  R  EL +     R  A   E  K Q 
Sbjct: 1739 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA---EEAKRQR 1795

Query: 757  SLAEKKMLDYERLQRAEAQG---------------KQEVE-SLREKLLVAEN----RLQA 796
             LAE+   D  R QRAEA+                K E E +L+EK   AEN    RL  
Sbjct: 1796 QLAEE---DAAR-QRAEAERVLAEKLAAIGEATRLKTEAEIALKEK--EAENERLRRLAE 1849

Query: 797  VEAL-------CSSQHTHMIES------NDISEETIRTKETVEGLQDKLNKRDKEVTALT 843
             EA         ++QH   IE            E  R K  VE    +  + ++E+ AL 
Sbjct: 1850 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1909

Query: 844  SQTEMLRAQVSALESKCKSGEKKVDALLKEK----------RRLEAELETVSRKTHDASG 893
            +  E   A  + LE +        +  L+ K          R+L AE E   R+  +   
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ 1969

Query: 894  QLVLISQELLRKERS----LNELRVLLLEANRHSPGPERDLSREVHKAEWRIKEQKLKDD 949
            + +   +E  R+ ++    +  L+  + EA R     E++ +R++  A+    +++L+ +
Sbjct: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ-EAAQKRLQAE 2028

Query: 950  IRGLREKLTGLDKEKSLSDQRRYSLIDP--SSAPELLRLQHQLMSTE-DALRDALDQAQQ 1006
             +     +   ++E   + Q+  S++D     A    R   +       A R+A    +Q
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088

Query: 1007 VEKLMEAMRSCPDKAQTIGNSGSA 1030
            VE+     +S  ++AQ    + +A
Sbjct: 2089 VEEAERLKQSAEEQAQARAQAQAA 2112



 Score = 73.6 bits (179), Expect = 9e-13
 Identities = 161/701 (22%), Positives = 287/701 (40%), Gaps = 145/701 (20%)

Query: 393  EKEIALLKAQHEQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEE-ERRKVEDLQFRVEE 451
            E+E       ++Q +   E+  Q        + + K D+  QLE  E R V  L+  +++
Sbjct: 933  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELK-DIRLQLEACETRTVHRLRLPLDK 991

Query: 452  ESITK-GDLETQTQLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEE 510
            E   +      + Q   A +  L + +    A+AE++L       L   +  +  L+ E 
Sbjct: 992  EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLA------LPEPSPAAPTLRSEL 1045

Query: 511  ELTLRRGEIEELQQC------------LLHSGPPPPDHPDAAEILRLRERLLSASKEHQR 558
            ELTL  G++E+++              L+  G        A E+LR  E  L   KE Q 
Sbjct: 1046 ELTL--GKLEQVRSLSAIYLEKLKTISLVIRGTQ-----GAEEVLRAHEEQL---KEAQA 1095

Query: 559  ESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKD----------KVQQATSENMG 608
                L +     L+A +A + KLRA  E        L+D          ++QQ   E   
Sbjct: 1096 VPATLPE-----LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1150

Query: 609  LMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLE----- 663
             ++ W+ ++  L       LE  +A L +    +Q+E+ +L     G ++ +  E     
Sbjct: 1151 EVERWRERVAQL-------LERWQAVL-AQTDVRQRELEQL-----GRQLRYYRESADPL 1197

Query: 664  ---LGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRH------------------ 702
               L + + + +   AM + + +A+RE+L++ Q  L  ++RH                  
Sbjct: 1198 GAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAI 1257

Query: 703  ---------WRAQLEVQASQHRLELQEAQDQ---RRDAELRVH--ELEKLDVEYRGQAQA 748
                     ++AQLE  AS  +    ++  +   +   +LR H  EL  L  +Y      
Sbjct: 1258 KDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY------ 1311

Query: 749  IEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVEALCSSQHTHM 808
            I+F+ E +    ++M + ERL  AE Q  +E E L E     E + Q  EA   ++    
Sbjct: 1312 IKFISETL----RRMEEEERL--AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1365

Query: 809  IESNDI----SEETIRTKETVEGLQDKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGE 864
             E+ ++     EE +R +E     Q +     +E+  L   +E   A++ A   + ++ E
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AEIQAKARQAEAAE 1422

Query: 865  KKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSP 924
            +    + +E R +  +LE   R+   A G+L  +     R E +  + R    EA R   
Sbjct: 1423 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR---ARAEEAEAQKRQAQEEAER--- 1476

Query: 925  GPERDLSREVHKAEWRIKEQKLKDDIRGLREKLTGLDKEKSLSDQRRYSLIDPSSAPELL 984
                 L R+V     R ++ +++   R   E     +K+++L             A E L
Sbjct: 1477 -----LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL------------QALEEL 1519

Query: 985  RLQHQLMSTEDALRDA-LDQAQQVEKLME-AMRSCPDKAQT 1023
            RLQ +    E  LR A +++A+QV+  +E A RS   + Q+
Sbjct: 1520 RLQAE--EAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 63/262 (24%), Positives = 114/262 (43%), Gaps = 34/262 (12%)

Query: 355  TALQEALKEKQQHIEQ-LLAERD--LERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
            T  QE L ++ Q ++Q  L+E+D  L+R            +E+E A L+   +  VA+A+
Sbjct: 2456 TVQQEQLLQETQALQQSFLSEKDSLLQRERF---------IEQEKAKLEQLFQDEVAKAQ 2506

Query: 412  EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIG 471
            +  +  +   + + +E+  L   +EE RR+  +      EE + +   E Q QLE  R  
Sbjct: 2507 QLREEQQRQQQQMEQERQRLVASMEEARRRQHE-----AEEGVRRKQEELQ-QLEQQR-R 2559

Query: 472  ELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVL--QLEEELTLRRGEIEELQQCLLHS 529
            + E+ L  E  +    L+ L +     +A    V   Q+    TL  G  + L       
Sbjct: 2560 QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR-DAL------D 2612

Query: 530  GPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKL--RAANEK 587
            GP     P+ +    LR ++   S +  +E+G+L  +  + L      VD+L  R     
Sbjct: 2613 GPAAEAEPEHS-FDGLRRKV---SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2668

Query: 588  YAQEVAGLKDKVQQATSENMGL 609
            Y Q  + +   + +AT+E + +
Sbjct: 2669 YLQGRSSIAGLLLKATNEKLSV 2690


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,024,987
Number of Sequences: 37866
Number of extensions: 1878006
Number of successful extensions: 23056
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 351
Number of HSP's successfully gapped in prelim test: 1223
Number of HSP's that attempted gapping in prelim test: 12041
Number of HSP's gapped (non-prelim): 6423
length of query: 1046
length of database: 18,247,518
effective HSP length: 113
effective length of query: 933
effective length of database: 13,968,660
effective search space: 13032759780
effective search space used: 13032759780
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.