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Search of human proteins with 116006955
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
(645 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 1293 0.0
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 1269 0.0
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 1236 0.0
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 1228 0.0
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 1186 0.0
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 1147 0.0
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 841 0.0
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 840 0.0
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 808 0.0
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 485 e-137
gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens] 461 e-130
gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens] 418 e-117
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 383 e-106
gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens] 380 e-105
gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens] 375 e-104
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 369 e-102
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 365 e-101
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 356 4e-98
gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens] 337 2e-92
gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens] 316 5e-86
gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens] 139 8e-33
gi|66730481 neuregulin 3 [Homo sapiens] 112 1e-24
gi|110349719 titin isoform N2-A [Homo sapiens] 56 9e-08
gi|110349717 titin isoform novex-2 [Homo sapiens] 56 9e-08
gi|110349713 titin isoform novex-1 [Homo sapiens] 56 9e-08
gi|110349715 titin isoform N2-B [Homo sapiens] 56 9e-08
gi|93102361 palladin [Homo sapiens] 53 8e-07
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 51 3e-06
gi|221316757 neurotrimin isoform 3 [Homo sapiens] 51 4e-06
gi|45594240 limbic system-associated membrane protein [Homo sapi... 51 4e-06
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 1293 bits (3347), Expect = 0.0
Identities = 645/645 (100%), Positives = 645/645 (100%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEA 240
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEA
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEA 240
Query: 241 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 300
EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG
Sbjct: 241 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 300
Query: 301 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 360
PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
Sbjct: 301 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 360
Query: 361 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 420
SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY
Sbjct: 361 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 420
Query: 421 RDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEE 480
RDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEE
Sbjct: 421 RDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEE 480
Query: 481 RPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ 540
RPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ
Sbjct: 481 RPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ 540
Query: 541 EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPL 600
EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPL
Sbjct: 541 EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPL 600
Query: 601 AASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV 645
AASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV
Sbjct: 601 AASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV 645
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 1269 bits (3285), Expect = 0.0
Identities = 637/645 (98%), Positives = 637/645 (98%), Gaps = 8/645 (1%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEA 240
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYK A
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYK--------A 232
Query: 241 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 300
EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG
Sbjct: 233 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 292
Query: 301 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 360
PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
Sbjct: 293 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 352
Query: 361 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 420
SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY
Sbjct: 353 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 412
Query: 421 RDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEE 480
RDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEE
Sbjct: 413 RDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEE 472
Query: 481 RPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ 540
RPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ
Sbjct: 473 RPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ 532
Query: 541 EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPL 600
EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPL
Sbjct: 533 EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPL 592
Query: 601 AASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV 645
AASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV
Sbjct: 593 AASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV 637
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 1236 bits (3199), Expect = 0.0
Identities = 624/645 (96%), Positives = 625/645 (96%), Gaps = 5/645 (0%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEA 240
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V +A
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQ-----EKA 235
Query: 241 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 300
EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG
Sbjct: 236 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 295
Query: 301 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 360
PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
Sbjct: 296 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 355
Query: 361 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 420
SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY
Sbjct: 356 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 415
Query: 421 RDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEE 480
RDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEE
Sbjct: 416 RDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMAVSPFMEEE 475
Query: 481 RPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ 540
RPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ
Sbjct: 476 RPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQ 535
Query: 541 EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPL 600
EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPL
Sbjct: 536 EPVKKLANSRRAKRTKPNGHIANRLEVDSNTSSQSSNSESETEDERVGEDTPFLGIQNPL 595
Query: 601 AASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV 645
AASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV
Sbjct: 596 AASLEATPAFRLADSRTNPAGRFSTQEEIQARLSSVIANQDPIAV 640
>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
Length = 624
Score = 1228 bits (3178), Expect = 0.0
Identities = 612/612 (100%), Positives = 612/612 (100%)
Query: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP
Sbjct: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 132
Query: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 133 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 192
Query: 214 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 273
NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 193 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 252
Query: 274 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 333
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 253 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 312
Query: 334 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 393
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 313 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 372
Query: 394 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 453
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 373 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 432
Query: 454 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 513
PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 433 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 492
Query: 514 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 573
SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 493 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 552
Query: 574 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 633
QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 553 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 612
Query: 634 SSVIANQDPIAV 645
SSVIANQDPIAV
Sbjct: 613 SSVIANQDPIAV 624
>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
Length = 607
Score = 1186 bits (3067), Expect = 0.0
Identities = 594/612 (97%), Positives = 595/612 (97%), Gaps = 17/612 (2%)
Query: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS
Sbjct: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS--- 129
Query: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 130 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 175
Query: 214 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 273
NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 176 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 235
Query: 274 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 333
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 236 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 295
Query: 334 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 393
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 296 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 355
Query: 394 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 453
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 356 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 415
Query: 454 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 513
PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 416 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 475
Query: 514 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 573
SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 476 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 535
Query: 574 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 633
QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 536 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 595
Query: 634 SSVIANQDPIAV 645
SSVIANQDPIAV
Sbjct: 596 SSVIANQDPIAV 607
>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
Length = 590
Score = 1147 bits (2967), Expect = 0.0
Identities = 577/612 (94%), Positives = 578/612 (94%), Gaps = 34/612 (5%)
Query: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG
Sbjct: 13 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 72
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN
Sbjct: 73 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------------------- 112
Query: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 213
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP
Sbjct: 113 --------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCP 158
Query: 214 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 273
NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK
Sbjct: 159 NEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTK 218
Query: 274 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 333
KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA
Sbjct: 219 KQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREA 278
Query: 334 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 393
ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP
Sbjct: 279 ETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGP 338
Query: 394 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 453
RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP
Sbjct: 339 RGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSP 398
Query: 454 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 513
PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD
Sbjct: 399 PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLREKKFDHHPQQFSSFHHNPAHD 458
Query: 514 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 573
SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS
Sbjct: 459 SNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRAKRTKPNGHIANRLEVDSNTSS 518
Query: 574 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 633
QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL
Sbjct: 519 QSSNSESETEDERVGEDTPFLGIQNPLAASLEATPAFRLADSRTNPAGRFSTQEEIQARL 578
Query: 634 SSVIANQDPIAV 645
SSVIANQDPIAV
Sbjct: 579 SSVIANQDPIAV 590
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 841 bits (2173), Expect = 0.0
Identities = 420/429 (97%), Positives = 421/429 (98%), Gaps = 8/429 (1%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEA 240
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYK A
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYK--------A 232
Query: 241 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 300
EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG
Sbjct: 233 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 292
Query: 301 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 360
PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
Sbjct: 293 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 352
Query: 361 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 420
SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY
Sbjct: 353 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 412
Query: 421 RDSPHSERY 429
RDSPHSER+
Sbjct: 413 RDSPHSERH 421
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 840 bits (2171), Expect = 0.0
Identities = 420/428 (98%), Positives = 420/428 (98%), Gaps = 8/428 (1%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEA 240
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYK A
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYK--------A 232
Query: 241 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 300
EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG
Sbjct: 233 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 292
Query: 301 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 360
PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
Sbjct: 293 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 352
Query: 361 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 420
SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY
Sbjct: 353 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 412
Query: 421 RDSPHSER 428
RDSPHSER
Sbjct: 413 RDSPHSER 420
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 808 bits (2087), Expect = 0.0
Identities = 407/429 (94%), Positives = 409/429 (95%), Gaps = 5/429 (1%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEA 240
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V +A
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQ-----EKA 235
Query: 241 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 300
EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG
Sbjct: 236 EELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANG 295
Query: 301 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 360
PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW
Sbjct: 296 PHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSHSW 355
Query: 361 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 420
SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY
Sbjct: 356 SNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSY 415
Query: 421 RDSPHSERY 429
RDSPHSER+
Sbjct: 416 RDSPHSERH 424
>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
Length = 308
Score = 485 bits (1248), Expect = e-137
Identities = 239/263 (90%), Positives = 243/263 (92%), Gaps = 5/263 (1%)
Query: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 226
++TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC FTG RC V
Sbjct: 13 TATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 72
Query: 227 ASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 286
+AEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS
Sbjct: 73 MKVQNQ-----EKAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQS 127
Query: 287 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 346
LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA
Sbjct: 128 LRSERNNMMNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTA 187
Query: 347 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 406
HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC
Sbjct: 188 HHSTTVTQTPSHSWSNGHTESILSESHSVIVMSSVENSRHSSPTGGPRGRLNGTGGPREC 247
Query: 407 NSFLRHARETPDSYRDSPHSERY 429
NSFLRHARETPDSYRDSPHSER+
Sbjct: 248 NSFLRHARETPDSYRDSPHSERH 270
>gi|116006959 neuregulin 1 isoform HRG-beta3 [Homo sapiens]
Length = 241
Score = 461 bits (1187), Expect = e-130
Identities = 230/230 (100%), Positives = 230/230 (100%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 230
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 230
>gi|116006965 neuregulin 1 isoform HRG-gamma [Homo sapiens]
Length = 211
Score = 418 bits (1075), Expect = e-117
Identities = 211/211 (100%), Positives = 211/211 (100%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 383 bits (983), Expect = e-106
Identities = 253/658 (38%), Positives = 355/658 (53%), Gaps = 104/658 (15%)
Query: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
Query: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
Query: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
+ N+ S+T +S +G H KC E K+
Sbjct: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
Query: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRV 248
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F KHLG E EAEELYQKRV
Sbjct: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRV 408
Query: 249 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 308
LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP P
Sbjct: 409 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 467
Query: 309 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 363
E +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS
Sbjct: 468 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 526
Query: 364 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 419
+ES+ S+S S I++SSV S+ +SP R R + H ++ DS
Sbjct: 527 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 584
Query: 420 YRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFME 478
RDSPHSERYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S +
Sbjct: 585 LRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLA 644
Query: 479 EERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPA 519
E++PLL P P + + S+++ A SLPA
Sbjct: 645 EQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPA 704
Query: 520 SPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR------- 564
SP RI ED+EYETTQE P P + A RR +R++ NG A R
Sbjct: 705 SPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDS 764
Query: 565 LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 617
L + S + S+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 765 LSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 822
>gi|236463969 neuregulin 1 isoform HRG-beta3b [Homo sapiens]
Length = 207
Score = 380 bits (976), Expect = e-105
Identities = 195/230 (84%), Positives = 196/230 (85%), Gaps = 34/230 (14%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESN +TSTSTTGTSHLV
Sbjct: 121 DSASANITIVESN----------------------------------ATSTSTTGTSHLV 146
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 230
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 147 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY 196
>gi|236462984 neuregulin 1 isoform HRG-gamma2 [Homo sapiens]
Length = 194
Score = 375 bits (964), Expect = e-104
Identities = 193/211 (91%), Positives = 194/211 (91%), Gaps = 17/211 (8%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESNEIITGMPASTEGAYV SS+TSTSTTGTSHLV
Sbjct: 121 DSASANITIVESNEIITGMPASTEGAYV-----------------SSATSTSTTGTSHLV 163
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 164 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 194
>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
Length = 858
Score = 369 bits (947), Expect = e-102
Identities = 251/664 (37%), Positives = 351/664 (52%), Gaps = 110/664 (16%)
Query: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
Query: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
Query: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
+ N+ S+T +S +G H KC E K+
Sbjct: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
Query: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY------KHLGIEFMEAEE 242
+CVNGG C+ ++ ++ S CKCPN F G RC + Y KHLG E EAEE
Sbjct: 352 YCVNGGVCYYIEGINQLS---CKCPNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEE 408
Query: 243 LYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPH 302
LYQKRVLTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP
Sbjct: 409 LYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPS 467
Query: 303 HPNPPPENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PS 357
HP PE +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T S
Sbjct: 468 HPRLDPEEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHES 526
Query: 358 HSWSNGHTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHA 413
H+WS +ES+ S+S S I++SSV S+ +SP R R + H
Sbjct: 527 HTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH- 585
Query: 414 RETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA- 472
++ DS RDSPHSERYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A
Sbjct: 586 -DSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAP 644
Query: 473 VSPFMEEERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS----------- 514
+S + E++PLL P P + + S+++ A
Sbjct: 645 ISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGS 704
Query: 515 -NSLPASPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR- 564
SLPASP RI ED+EYETTQE P P + A RR +R++ NG A R
Sbjct: 705 LGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRA 764
Query: 565 ------LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLA 613
L + S + S+++ + D+ G E TPFLG++ A ++ P A
Sbjct: 765 RAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAA 824
Query: 614 DSRT 617
DSRT
Sbjct: 825 DSRT 828
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 365 bits (937), Expect = e-101
Identities = 248/658 (37%), Positives = 350/658 (53%), Gaps = 112/658 (17%)
Query: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
Query: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
Query: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
+ N+ S+T +S +G H KC E K+
Sbjct: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
Query: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRV 248
+CVNGG C+ ++ ++ S CKCP +TGDRCQ + M +F K AEELYQKRV
Sbjct: 352 YCVNGGVCYYIEGINQLS---CKCPVGYTGDRCQQFAMVNFSK--------AEELYQKRV 400
Query: 249 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 308
LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP P
Sbjct: 401 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 459
Query: 309 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 363
E +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS
Sbjct: 460 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 518
Query: 364 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 419
+ES+ S+S S I++SSV S+ +SP R R + H ++ DS
Sbjct: 519 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 576
Query: 420 YRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFME 478
RDSPHSERYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S +
Sbjct: 577 LRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLA 636
Query: 479 EERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPA 519
E++PLL P P + + S+++ A SLPA
Sbjct: 637 EQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPA 696
Query: 520 SPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR------- 564
SP RI ED+EYETTQE P P + A RR +R++ NG A R
Sbjct: 697 SPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDS 756
Query: 565 LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 617
L + S + S+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 757 LSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 814
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 356 bits (913), Expect = 4e-98
Identities = 245/658 (37%), Positives = 347/658 (52%), Gaps = 106/658 (16%)
Query: 11 GKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKW 70
GK KKE G + A P+LK+MKSQ G K L+CE ++ ++W
Sbjct: 218 GKNLKKEVGKILCTDCATR-------PKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRW 270
Query: 71 FKNGNELNRKNKPQNIKIQKKPGK--SELRINKASLADSGEYMCKVISKLGNDSASANIT 128
FK+G ELNR ++I+I+ G+ S L+ NK + D+GEY+C+ + LG D+ +
Sbjct: 271 FKDGKELNRS---RDIRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLY 327
Query: 129 IVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKT 188
+ N+ S+T +S +G H KC E K+
Sbjct: 328 V----------------------------------NSVSTTLSSWSG--HARKCNETAKS 351
Query: 189 FCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRV 248
+CVNGG C+ ++ ++ S CKCPN F G RC + Y + +AEELYQKRV
Sbjct: 352 YCVNGGVCYYIEGINQLS---CKCPNGFFGQRCLEKLPLRLY--MPDPKQKAEELYQKRV 406
Query: 249 LTITGICIALLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPP 308
LTITGIC+ALLVVGI+CVVAYCKTKKQRK++H+ LRQ++ N ++ANGP HP P
Sbjct: 407 LTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQN-RSLANGPSHPRLDP 465
Query: 309 ENVQLVNQYVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQT-----PSHSWSNG 363
E +Q+ + Y+SKNV +++H++ RE ET+FS SH S +HH +T T T SH+WS
Sbjct: 466 EEIQMAD-YISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLE 524
Query: 364 HTESILSESHSVIVMSSVENSRHSSP----TGGPRGRLNGTGGPRECNSFLRHARETPDS 419
+ES+ S+S S I++SSV S+ +SP R R + H ++ DS
Sbjct: 525 RSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH--DSVDS 582
Query: 420 YRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSMA-VSPFME 478
RDSPHSERYVSA+TTPAR+SPVDFH + + P E++ P S+ VS+P A +S +
Sbjct: 583 LRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLA 642
Query: 479 EERPLLLVTPPRLREKKFDHHP-------QQFSSFHHNPAHDS------------NSLPA 519
E++PLL P P + + S+++ A SLPA
Sbjct: 643 EQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPA 702
Query: 520 SPLRIVEDEEYETTQEYEPAQEPVKKL--------ANSRRAKRTKPNGHIANR------- 564
SP RI ED+EYETTQE P P + A RR +R++ NG A R
Sbjct: 703 SPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDS 762
Query: 565 LEVDSNTSSQSSNSESETEDERVG----EDTPFLGIQNPL-AASLEATPAFRLADSRT 617
L + S + S+++ + D+ G E TPFLG++ A ++ P ADSRT
Sbjct: 763 LSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT 820
>gi|236464356 neuregulin 1 isoform HRG-gamma3 [Homo sapiens]
Length = 177
Score = 337 bits (864), Expect = 2e-92
Identities = 176/211 (83%), Positives = 177/211 (83%), Gaps = 34/211 (16%)
Query: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS
Sbjct: 1 MSERKEGRGKGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETS 60
Query: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN
Sbjct: 61 SEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGN 120
Query: 121 DSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLV 180
DSASANITIVESN +TSTSTTGTSHLV
Sbjct: 121 DSASANITIVESN----------------------------------ATSTSTTGTSHLV 146
Query: 181 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 211
KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK
Sbjct: 147 KCAEKEKTFCVNGGECFMVKDLSNPSRYLCK 177
>gi|116006967 neuregulin 1 isoform GGF2 [Homo sapiens]
Length = 422
Score = 316 bits (809), Expect = 5e-86
Identities = 165/209 (78%), Positives = 167/209 (79%), Gaps = 34/209 (16%)
Query: 22 KKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81
KK S + ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN
Sbjct: 237 KKEVSRVLCKRCALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 296
Query: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPA 141
KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN
Sbjct: 297 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN-------- 348
Query: 142 STEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 201
+TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD
Sbjct: 349 --------------------------ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD 382
Query: 202 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 230
LSNPSRYLCKCPNEFTGDRCQNYVMASFY
Sbjct: 383 LSNPSRYLCKCPNEFTGDRCQNYVMASFY 411
>gi|7669518 neuregulin 1 isoform SMDF [Homo sapiens]
Length = 296
Score = 139 bits (350), Expect = 8e-33
Identities = 63/63 (100%), Positives = 63/63 (100%)
Query: 168 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 227
STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA
Sbjct: 223 STSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 282
Query: 228 SFY 230
SFY
Sbjct: 283 SFY 285
>gi|66730481 neuregulin 3 [Homo sapiens]
Length = 696
Score = 112 bits (280), Expect = 1e-24
Identities = 105/421 (24%), Positives = 188/421 (44%), Gaps = 40/421 (9%)
Query: 149 SSESPIRISVSTEGANTSSS-----TSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLS 203
SS S S +T TS+S T+ ST + H C +K+ +C+N GECF+++ L+
Sbjct: 252 SSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLT 311
Query: 204 NPSRYLCKCPNEFTGDRCQNY------VMASFYKHLGIEFMEAEELYQKRVLTITGICIA 257
++ C+C + G RC + +++ HLGIEFME+EE+YQ++VL+I+ I
Sbjct: 312 GSHKH-CRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFG 370
Query: 258 LLVVGIMCVVAYCKTKKQRKKLHDRLRQSLRSERNNMMNIANGPHHPNPPPENVQLVN-Q 316
+++VG+ C Y K+KKQ K++ ++L+ + ++ + N +VQL N
Sbjct: 371 IVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYS 430
Query: 317 YVSKNVISSEHIVEREAETSFSTSHYTSTAHHSTTVTQTPSH-SWSNGHTESILSESHSV 375
V ++ +++ +E+ E+SF S +P S S H S+ S
Sbjct: 431 KVERHPVTA---LEKMMESSF-------VGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPG 480
Query: 376 IVMSSVENSRHSSPTGGPRGRLNGTGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTT 435
+ + PR RL G GP + E+ +D+ + Y S+
Sbjct: 481 QRSGMLHRNAFRRTPPSPRSRLGGIVGPA-----YQQLEESRIPDQDTIPCQGYSSSGLK 535
Query: 436 PARMSPVDFHTPSSPKSP---PSEMSPPVSSMTVSMPSMAVSPFMEEERPLLLVTPPRLR 492
R + ++ PS +P E V + S+ + P + E L + P +
Sbjct: 536 TQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQM--PGIS 593
Query: 493 EKKFDHHPQQFSSFHHNPAHDSNSLPASPLRIVEDEEYETTQEYEPAQEPVKKLANSRRA 552
E K ++ ++ + S+P S I E +E + E QE ++ L ++RR+
Sbjct: 594 EVK----SIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKIL--LETVQEQIRILTDARRS 647
Query: 553 K 553
+
Sbjct: 648 E 648
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 56.2 bits (134), Expect = 9e-08
Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P + + +SQ G ++ CE S E S +WFKN ++ + N+ I +
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 33189
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 148
L I AS++DSG+Y K + G SA+A++ ++ S E++ T S +G++
Sbjct: 33190 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 33248
Query: 149 SSESPIRISVSTEGANTSSSTSTSTTGTSHL 179
S +++S S + A+ SS +S+S + + +
Sbjct: 33249 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 33278
Score = 53.5 bits (127), Expect = 6e-07
Identities = 56/227 (24%), Positives = 91/227 (40%), Gaps = 31/227 (13%)
Query: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
A P ++++ E A G CE S ++RF+WFK G E+ +K I+
Sbjct: 3454 AAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIYESDK---CSIRSSKY 3509
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
S L I + + D GEY CK ++ G+ S +A +T+ E AY +
Sbjct: 3510 ISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTE--------------AYPPTFLS 3555
Query: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKE-------KTFCVNGGECFMVKDLSN-- 204
S++T + T TGT + +K+ + ++ E + +LSN
Sbjct: 3556 RPKSLTTFVGKAAKFICT-VTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLT 3614
Query: 205 ---PSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRV 248
Y CK N+F D CQ ++ H E + K+V
Sbjct: 3615 IQDRGVYSCKASNKFGADICQAELIIIDKPHFIKELEPVQSAINKKV 3661
Score = 48.9 bits (115), Expect = 1e-05
Identities = 51/222 (22%), Positives = 88/222 (39%), Gaps = 30/222 (13%)
Query: 44 SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 103
S++ GS + L+ T + L +WFK EL + I K+ +S L +
Sbjct: 4214 SKDVLPGSAVCLK-STFQGSTPLTIRWFKGNKELVSGG---SCYITKEALESSLELYLVK 4269
Query: 104 LADSGEYMCKVISKLGNDSASANITI---------VESNEIITGMPASTEGAYVSSESPI 154
+DSG Y CKV + G SAN+ + +E ++++ A+ V+ PI
Sbjct: 4270 TSDSGTYTCKVSNVAGGVECSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPI 4329
Query: 155 RISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD--LSNPSRYLCKC 212
+I T AN +K + K + V + D + + Y+C+
Sbjct: 4330 KI---TWFANDRE------------IKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEA 4374
Query: 213 PNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGI 254
NE D C + V+ + EF E L + V+ + +
Sbjct: 4375 QNEAGSDHCSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEV 4416
Score = 48.9 bits (115), Expect = 1e-05
Identities = 49/189 (25%), Positives = 84/189 (44%), Gaps = 13/189 (6%)
Query: 36 PPR-LKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
PP+ +K++++ + A G + L C+ S ++ WF+N +EL+ K I
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGS-PEIKVSWFRNDSELHESWKYNMSFINSV-- 6419
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
+ L IN+AS DSG+Y+C+ + +G+ S S +T V++ + T P S GA S+
Sbjct: 6420 -ALLTINEASAEDSGDYICEAHNGVGDASCSTALT-VKAPPVFTQKP-SPVGALKGSDVI 6476
Query: 154 IRISVS-TEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKC 212
++ +S T S K K ++ + + S+ Y CK
Sbjct: 6477 LQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLH----ILNLEASDVGEYHCKA 6532
Query: 213 PNEFTGDRC 221
NE D C
Sbjct: 6533 TNEVGSDTC 6541
Score = 48.1 bits (113), Expect = 2e-05
Identities = 49/207 (23%), Positives = 84/207 (40%), Gaps = 37/207 (17%)
Query: 31 QSPALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQ 89
Q LPP +++K E G + L C + + ++ W+++G L +N++
Sbjct: 6169 QERQLPPSFARQLKDIEQTVGLPVTLTCRLNGS-APIQVCWYRDGVLLR---DDENLQTS 6224
Query: 90 KKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE------------SNEIIT 137
+ L+I + L+ SG+Y C + LG S+SA +T E S ++I
Sbjct: 6225 FVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIA 6284
Query: 138 GMPASTEGAYVSSESPIRISVSTEGANT---SSSTSTSTTGTSHLVKCAEKEKTFCVNGG 194
G A E +V+ P+RI+ S + + T T T HL + V G
Sbjct: 6285 GESADFE-CHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHL-------RILKVGKG 6336
Query: 195 ECFMVKDLSNPSRYLCKCPNEFTGDRC 221
+ +Y C+ N+ D C
Sbjct: 6337 D---------SGQYTCQATNDVGKDMC 6354
Score = 47.4 bits (111), Expect = 4e-05
Identities = 26/98 (26%), Positives = 49/98 (50%), Gaps = 5/98 (5%)
Query: 35 LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
+PP K++ + GS + + C+ S + +WFK+G E++ K + + ++
Sbjct: 5235 IPPSFTKKLTKMDKVLGSSIHMECKVSGSLP-ISAQWFKDGKEISTSAKYRLVCHERSVS 5293
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
L +N L D+ Y CKV + G+D+ S +T+ E
Sbjct: 5294 ---LEVNNLELEDTANYTCKVSNVAGDDACSGILTVKE 5328
Score = 46.6 bits (109), Expect = 7e-05
Identities = 27/98 (27%), Positives = 48/98 (48%), Gaps = 5/98 (5%)
Query: 35 LPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
+PP K++K +S GS + L C + + + +WFK+ E++ K K
Sbjct: 4673 IPPSFTKKLKKMDSIKGSFIDLECIVAGSHP-ISIQWFKDDQEISASEK---YKFSFHDN 4728
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
+ L I++ DSG Y C +K G++ S ++T+ E
Sbjct: 4729 TAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKE 4766
Score = 46.6 bits (109), Expect = 7e-05
Identities = 54/211 (25%), Positives = 79/211 (37%), Gaps = 31/211 (14%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P +++K +GS +V+ C+ + WF GNE++ K Q
Sbjct: 7682 PSFTRKLKETNGLSGSSVVMECKVYGS-PPISVSWFHEGNEISSGRKYQTTLTDNT---C 7737
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIR 155
L +N +DSG+Y C + G+D SA +T+ E P S +V P+
Sbjct: 7738 ALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVRE--------PPS----FVQKPDPMD 7785
Query: 156 ISVSTEGANTSSSTSTST------TGTSHLV---KCAEKEKTFCVNGGECFMVKDLSNPS 206
+ T TS T G+S LV +C + V E F V D S
Sbjct: 7786 VLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLED-SVAELELFDV-DTSQSG 7843
Query: 207 RYLCKCPNEFTGDRCQNYVM----ASFYKHL 233
Y C NE C ++ A F K L
Sbjct: 7844 EYTCIVSNEAGKASCTTHLYIKAPAKFVKRL 7874
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 4/96 (4%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P +KE++ +SA K+ L C+ + + W K+G +L ++ KI + +
Sbjct: 3644 PHFIKELEPVQSAINKKVHLECQVDED-RKVTVTWSKDGQKLP---PGKDYKICFEDKIA 3699
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
L I A L DSG Y+C ++ G+ S SA +T+ E
Sbjct: 3700 TLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVRE 3735
Score = 45.8 bits (107), Expect = 1e-04
Identities = 42/195 (21%), Positives = 75/195 (38%), Gaps = 17/195 (8%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P ++E+K E S + L CE + W KN E+ K + +
Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGT-PPFEVTWLKNNREIRSSKK---YTLTDRVSVF 5010
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIR 155
L I K +D+GEY C V ++ G+ S S + + E I + + + +
Sbjct: 5011 NLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFI---------KKIENTTTVL 5061
Query: 156 ISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFC--VNGGECFMVKDLSN--PSRYLCK 211
S +T + + S S T E + + V+ ++ + N RY C+
Sbjct: 5062 KSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQ 5121
Query: 212 CPNEFTGDRCQNYVM 226
NE +RC +++
Sbjct: 5122 AKNESGVERCYAFLL 5136
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 52 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 111
++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+
Sbjct: 11679 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 11732
Query: 112 CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
C G D AN+T VE+ I P +V + I +S
Sbjct: 11733 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 11775
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/194 (22%), Positives = 79/194 (40%), Gaps = 33/194 (17%)
Query: 40 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
K +++ +S L C+ + +R WFK+G E+ ++ +I G + L I
Sbjct: 4117 KPLRNVDSVVNGTCRLDCKIAGSLP-MRVSWFKDGKEIAASDR---YRIAFVEGTASLEI 4172
Query: 100 NKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
+ + D+G + C+ + +G+ +S + + E +T P S + V S + + +
Sbjct: 4173 IRVDMNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVT-KPGSKD---VLPGSAVCLKST 4228
Query: 160 TEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD------------LSNPSR 207
+G ST T K KE V+GG C++ K+ S+
Sbjct: 4229 FQG---------STPLTIRWFK-GNKE---LVSGGSCYITKEALESSLELYLVKTSDSGT 4275
Query: 208 YLCKCPNEFTGDRC 221
Y CK N G C
Sbjct: 4276 YTCKVSNVAGGVEC 4289
Score = 45.1 bits (105), Expect = 2e-04
Identities = 53/194 (27%), Positives = 77/194 (39%), Gaps = 28/194 (14%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
+++ +S + G L C T + L KWFK+G EL NK + K G L+
Sbjct: 7589 VEKPESIKVTTGDTCTLEC-TVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG---LK 7644
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESN--EIITGMPASTEGAYVSS------ 150
I + +DSG Y +V + +G DS +A++ + + T T G SS
Sbjct: 7645 IINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKETNGLSGSSVVMECK 7704
Query: 151 ---ESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSR 207
PI +S EG SS TT T + CA VN + + S+
Sbjct: 7705 VYGSPPISVSWFHEGNEISSGRKYQTTLTDN--TCA-----LTVN------MLEESDSGD 7751
Query: 208 YLCKCPNEFTGDRC 221
Y C N D C
Sbjct: 7752 YTCIATNMAGSDEC 7765
Score = 44.7 bits (104), Expect = 3e-04
Identities = 42/172 (24%), Positives = 72/172 (41%), Gaps = 22/172 (12%)
Query: 17 ERGSGKKPESAAGSQSPALPPR--LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNG 74
E SGK SA Q L P +K+++ + + G L+C+ + + W+K
Sbjct: 7943 ENASGKDSCSA---QILILEPPYFVKQLEPVKVSVGDSASLQCQLAGT-PEIGVSWYKGD 7998
Query: 75 NELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESN- 133
+L K+ + + L N+ + DSGEY+CK + +G SAS +T+ E
Sbjct: 7999 TKLRPTT---TYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKL 8055
Query: 134 -----------EIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTT 174
+ G+P + A +S PI +S +G S + T+
Sbjct: 8056 PPSFSRQLRDVQETVGLPVVFDCA-ISGSEPISVSWYKDGKPLKDSPNVQTS 8106
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 26/193 (13%)
Query: 57 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
CE S E + + KWFK+G E+ + K I K L INK L D EY C+V +
Sbjct: 12395 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 12449
Query: 117 KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGANT---SSSTST 171
S +T++E + T A+ E VS I++ VS GA
Sbjct: 12450 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGAEVIWYKGDEEI 12502
Query: 172 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY- 230
TG ++ K N L + Y C+ P+ T + + + +A+ +
Sbjct: 12503 IETGRYEILTEGRKRILVIQNA-------HLEDAGNYNCRLPSSRTDGKVKVHELAAEFI 12555
Query: 231 -KHLGIEFMEAEE 242
K +E +E E+
Sbjct: 12556 SKPQNLEILEGEK 12568
Score = 44.3 bits (103), Expect = 4e-04
Identities = 29/101 (28%), Positives = 47/101 (46%), Gaps = 13/101 (12%)
Query: 66 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
++ WFKN EL+ N +++ ++ L I + DSG Y C+ ++ +G+DS S
Sbjct: 3767 IQVTWFKNNKELSESN---TVRMYFVNSEAILDITDVKVEDSGSYSCEAVNDVGSDSCST 3823
Query: 126 NITI---------VESNEIITGMPASTEGAYVSSESPIRIS 157
I I +E +I+ G A + VS P IS
Sbjct: 3824 EIVIKEPPSFIKTLEPADIVRGTNALLQ-CEVSGTGPFEIS 3863
Score = 44.3 bits (103), Expect = 4e-04
Identities = 44/202 (21%), Positives = 81/202 (40%), Gaps = 13/202 (6%)
Query: 17 ERGSGKKPESAAGSQSPALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGN 75
E +G S + + + PP + S A GS ++L+CE S W K+
Sbjct: 6438 EAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVILQCEISGT-PPFEVVWVKDRK 6496
Query: 76 ELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
++ K KI K + L I +D GEY CK +++G+D+ S ++ E
Sbjct: 6497 QVRNSKK---FKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSDTCSCSVKFKEPPRF 6553
Query: 136 ITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGE 195
+ + S + +R V EG S G +++ +E + ++
Sbjct: 6554 VKKL--SDTSTLIGDAVELRAIV--EGFQPISVVWLKDRG--EVIRESENTRISFIDNIA 6607
Query: 196 CFMV--KDLSNPSRYLCKCPNE 215
+ + SN +Y+C+ N+
Sbjct: 6608 TLQLGSPEASNSGKYICQIKND 6629
Score = 43.9 bits (102), Expect = 5e-04
Identities = 32/130 (24%), Positives = 57/130 (43%), Gaps = 14/130 (10%)
Query: 34 ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
+ PP ++ +K+ E + L CE S W+K+ +L K KI K
Sbjct: 5521 SFPPIVETLKNAEVS------LECELSGT-PPFEVVWYKDKRQLRSSKK---YKIASKNF 5570
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESP 153
+ + I +D GEY CK +++G+D+ + + E ++ + + T V + P
Sbjct: 5571 HTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKLNSLT----VVAGEP 5626
Query: 154 IRISVSTEGA 163
+ S EGA
Sbjct: 5627 AELQASIEGA 5636
Score = 43.1 bits (100), Expect = 8e-04
Identities = 46/195 (23%), Positives = 79/195 (40%), Gaps = 17/195 (8%)
Query: 30 SQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQ 89
++ P +L+ K ++ S+L + S E +R WF+N +EL +K + I
Sbjct: 5420 TEPPKFVKKLEASKIVKAGDSSRLECKIAGSPE---IRVVWFRNEHELPASDKYRMTFID 5476
Query: 90 KKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE---GA 146
+ +++N S DSG+++C+ + G+ S S + IV+ + + P E A
Sbjct: 5477 SV---AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKV-IVKEPPVFSSFPPIVETLKNA 5532
Query: 147 YVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPS 206
VS E + T +S K A K ++ + D S+
Sbjct: 5533 EVSLECELS---GTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIH----ILNVDTSDIG 5585
Query: 207 RYLCKCPNEFTGDRC 221
Y CK NE D C
Sbjct: 5586 EYHCKAQNEVGSDTC 5600
Score = 43.1 bits (100), Expect = 8e-04
Identities = 32/137 (23%), Positives = 59/137 (43%), Gaps = 14/137 (10%)
Query: 31 QSPALPPRLKEMKSQESAA-GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQ 89
+ P PP + + + + G + L C +R +W K G E+ ++
Sbjct: 8340 KEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGS-EPIRIQWLKAGREIKPSDR---CSFS 8395
Query: 90 KKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGA--- 146
G + L + + ADSG+Y+CK + G+D+ + +TI + + PA+ + A
Sbjct: 8396 FASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAV---APATKKAAVDG 8452
Query: 147 ---YVSSESPIRISVST 160
+VS IR+ T
Sbjct: 8453 RLFFVSEPQSIRVVEKT 8469
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/113 (25%), Positives = 52/113 (46%), Gaps = 13/113 (11%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P ++++K + G+ +VL C S + + WF++GNE+ K Q+
Sbjct: 6741 PSFIRKLKDVNAILGASVVLECRVSGS-APISVGWFQDGNEIVSGPKCQS---SFSENVC 6796
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE---------SNEIITGM 139
L ++ +D+G Y C + G+D SA +T+ E S E++ GM
Sbjct: 6797 TLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGM 6849
Score = 41.6 bits (96), Expect = 0.002
Identities = 27/94 (28%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P ++ ++ E+ G L+C+ +R W+K +L ++ P K+Q K +
Sbjct: 7020 PYFIEPLEHVEAVIGEPATLQCKVDGT-PEIRISWYKEHTKL--RSAPA-YKMQFKNNVA 7075
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITI 129
L INK +D GEY CK + +G ++SA + I
Sbjct: 7076 SLVINKVDHSDVGEYSCKADNSVGAVASSAVLVI 7109
Score = 41.6 bits (96), Expect = 0.002
Identities = 35/149 (23%), Positives = 60/149 (40%), Gaps = 16/149 (10%)
Query: 25 ESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 84
++ GS + PPR + S S K V T + WFK+ E+ R++
Sbjct: 7480 DTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRES--D 7537
Query: 85 NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
NI I + L+ ++ A++G+Y C++ + G A ++++E I+
Sbjct: 7538 NIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPATIV-------- 7589
Query: 145 GAYVSSESPIRISVSTEGANTSSSTSTST 173
E P I V+T T T T
Sbjct: 7590 ------EKPESIKVTTGDTCTLECTVAGT 7612
Score = 40.8 bits (94), Expect = 0.004
Identities = 44/186 (23%), Positives = 74/186 (39%), Gaps = 17/186 (9%)
Query: 40 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
KE K E ++L E + WFK+ N + R + IQ L+I
Sbjct: 4397 KEFKPIEVLKEYDVMLLAEVAGT-PPFEITWFKD-NTILRSGRKYKTFIQDH--LVSLQI 4452
Query: 100 NKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
K AD+GEY C+V +++G+ SA +T+ E I + S S +R +
Sbjct: 4453 LKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFI---------KKIESTSSLRGGTA 4503
Query: 160 TEGANTSSSTSTSTTGTSHLVKCAEKEK---TFCVNGGECFMVK-DLSNPSRYLCKCPNE 215
A S + T + E + TF N ++ ++ + +Y+C+ N+
Sbjct: 4504 AFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKND 4563
Query: 216 FTGDRC 221
RC
Sbjct: 4564 AGIQRC 4569
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/111 (27%), Positives = 48/111 (43%), Gaps = 11/111 (9%)
Query: 26 SAAGSQSPALPPRLKEMK-------SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELN 78
+AAGS S + ++KE E+ G+ + L CE W+K+ EL
Sbjct: 7382 NAAGSASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGT-PPFHVSWYKDKRELR 7440
Query: 79 RKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
K KI + + + I AD GEY CK + +G+D+ +I +
Sbjct: 7441 SGKK---YKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIAL 7488
Score = 40.0 bits (92), Expect = 0.007
Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 5/113 (4%)
Query: 33 PALPPRLKE-MKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 91
P PP L +K+ G + L C S Y S W++ ++ + +I +
Sbjct: 939 PVTPPTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQ 994
Query: 92 PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
G + L I +A DSG + C +++ G S S + + S E A TE
Sbjct: 995 SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1047
Score = 40.0 bits (92), Expect = 0.007
Identities = 41/182 (22%), Positives = 71/182 (39%), Gaps = 12/182 (6%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P + E++ E+A G + L+C+ + + W+K +L + +
Sbjct: 6079 PYFVTELEPLEAAVGDSVSLQCQVAGT-PEITVSWYKGDTKLR---PTPEYRTYFTNNVA 6134
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIR 155
L NK ++ DSGEY CK + +G S+ I E +P S E +
Sbjct: 6135 TLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQ-----LPPSFARQLKDIEQTVG 6189
Query: 156 ISVS-TEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMV--KDLSNPSRYLCKC 212
+ V+ T N S+ L++ E +T V+ + DLS+ +Y C
Sbjct: 6190 LPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSA 6249
Query: 213 PN 214
N
Sbjct: 6250 SN 6251
Score = 40.0 bits (92), Expect = 0.007
Identities = 25/94 (26%), Positives = 39/94 (41%), Gaps = 4/94 (4%)
Query: 49 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 108
AG C + +R W K+ E+ N I LRI K DSG
Sbjct: 6284 AGESADFECHVTGA-QPMRITWSKDNKEIRPGG---NYTITCVGNTPHLRILKVGKGDSG 6339
Query: 109 EYMCKVISKLGNDSASANITIVESNEIITGMPAS 142
+Y C+ + +G D SA +++ E + + + AS
Sbjct: 6340 QYTCQATNDVGKDMCSAQLSVKEPPKFVKKLEAS 6373
Score = 40.0 bits (92), Expect = 0.007
Identities = 41/152 (26%), Positives = 61/152 (40%), Gaps = 19/152 (12%)
Query: 33 PALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 92
P+ RL E + KL R S + W+KN E+ + N +I K
Sbjct: 8249 PSFTKRLSETVEETEGNSFKLEGRVAGSQP---ITVAWYKNNIEIQPTS---NCEITFKN 8302
Query: 93 GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVES------NEIITGMPASTEGA 146
L++ KA + D+G Y CKV + G+ +++I I E ++ +T + S EG
Sbjct: 8303 NTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVS-EGE 8361
Query: 147 Y------VSSESPIRISVSTEGANTSSSTSTS 172
Y V PIRI G S S
Sbjct: 8362 YVQLSCHVQGSEPIRIQWLKAGREIKPSDRCS 8393
Score = 39.3 bits (90), Expect = 0.011
Identities = 25/102 (24%), Positives = 51/102 (50%), Gaps = 4/102 (3%)
Query: 36 PPR-LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 94
PPR +K++ + G + LR + + W K+ E+ R++ +N +I
Sbjct: 6550 PPRFVKKLSDTSTLIGDAVELRAIVEG-FQPISVVWLKDRGEVIRES--ENTRISFIDNI 6606
Query: 95 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 136
+ L++ ++SG+Y+C++ + G SA +T++E II
Sbjct: 6607 ATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLEPARII 6648
Score = 38.9 bits (89), Expect = 0.015
Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 2/103 (1%)
Query: 25 ESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 84
E AG PA P + + Q+ G +V C+ + W K+G L +
Sbjct: 1071 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-Y 1128
Query: 85 NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 127
+ K+ G+ +L I+ D+GEY V +K G SASA++
Sbjct: 1129 KVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 38.9 bits (89), Expect = 0.015
Identities = 20/86 (23%), Positives = 40/86 (46%), Gaps = 4/86 (4%)
Query: 46 ESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLA 105
++ G C + ++ W K+ E+ K Q ++ + L+++K
Sbjct: 8163 DAVVGESADFECHVTGT-QPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKG--- 8218
Query: 106 DSGEYMCKVISKLGNDSASANITIVE 131
DSG+Y C ++++G DS +A + I E
Sbjct: 8219 DSGQYTCYAVNEVGKDSCTAQLNIKE 8244
Score = 38.9 bits (89), Expect = 0.015
Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 92
PP++ + E+ SK + + E S LR K W+K+G +L Q
Sbjct: 32717 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 32771
Query: 93 GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 149
G EL+IN + +D GEY+C++ + G + +E ++ + + + +
Sbjct: 32772 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 32831
Query: 150 SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 191
+ES + + SS TG ++ F V
Sbjct: 32832 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 32873
Score = 38.5 bits (88), Expect = 0.019
Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 3/63 (4%)
Query: 69 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
KWFK+G EL +K KI S L+I DSGEY +V + +G S A I
Sbjct: 4611 KWFKDGQELTLGSK---YKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARIN 4667
Query: 129 IVE 131
+++
Sbjct: 4668 VLD 4670
Score = 37.4 bits (85), Expect = 0.043
Identities = 39/168 (23%), Positives = 66/168 (39%), Gaps = 26/168 (15%)
Query: 67 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 126
+ KWFK EL ++ I + +EL + + +SG+Y C V + G+ S + +
Sbjct: 6864 KVKWFKGSRELV---PGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTH 6920
Query: 127 ITIVESNEII---------TGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTS 177
+ + E + TG P E Y + PI +S + S S S T T
Sbjct: 6921 LFVKEPATFVKRLADFSVETGSPIVLEATYTGT-PPISVSWIKDEYLISQSERCSITMT- 6978
Query: 178 HLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYV 225
EK+ + + + + ++Y C NE D C+ V
Sbjct: 6979 --------EKSTILE----ILESTIEDYAQYSCLIENEAGQDICEALV 7014
Score = 37.4 bits (85), Expect = 0.043
Identities = 39/183 (21%), Positives = 64/183 (34%), Gaps = 23/183 (12%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
+K + G L+L T + + W KNG + Q I + L
Sbjct: 7871 VKRLNDYSIEKGKPLILE-GTFTGTPPISVTWKKNGINVTPS---QRCNITTTEKSAILE 7926
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISV 158
I +++ D+G+Y C + + G DS SA I I+E +V P+++SV
Sbjct: 7927 IPSSTVEDAGQYNCYIENASGKDSCSAQILILE------------PPYFVKQLEPVKVSV 7974
Query: 159 STEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVN-------GGECFMVKDLSNPSRYLCK 211
+ T G S + T F D+++ Y+CK
Sbjct: 7975 GDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICK 8034
Query: 212 CPN 214
N
Sbjct: 8035 AEN 8037
Score = 37.4 bits (85), Expect = 0.043
Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 15/152 (9%)
Query: 14 KKKERGSG--KKPESAAGS-QSPALPPR-LKEMK----SQESAAGSKLVLRCETSSEYSS 65
+K GSG K P+ A + Q A+P + +KE+K ++ GS + C S S+
Sbjct: 11089 RKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSP--ST 11146
Query: 66 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
W K+G+ + K + I K +L I L+D+GEY C + +LGN ++
Sbjct: 11147 AITTWMKDGSNIRESPKHRFIADGKD---RKLHIIDVQLSDAGEYTC--VLRLGNKEKTS 11201
Query: 126 NITIVESNEIITGMPASTEGAYVSSESPIRIS 157
+V + + E V P+ +S
Sbjct: 11202 TAKLVVEELPVRFVKTLEEEVTVVKGQPLYLS 11233
Score = 37.4 bits (85), Expect = 0.043
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W+K+G ++ + + + G +L IN + D EY +K G DS A +T+
Sbjct: 31723 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 31782
Score = 37.0 bits (84), Expect = 0.056
Identities = 35/189 (18%), Positives = 78/189 (41%), Gaps = 26/189 (13%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P +++ +SQ+ +++ L+ + + KWFK+ EL+ + K +
Sbjct: 4768 PYFVEKPQSQDVNPNTRVQLKALVGGT-APMTIKWFKDNKELHSGAARS---VWKDDTST 4823
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNE---------IITGMPASTEGA 146
L + A DSG Y+C++ + +G ++ A + + E + ++ ++T
Sbjct: 4824 SLELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFEC 4883
Query: 147 YVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPS 206
++ IR+S +G + T H + + TF ++G + N
Sbjct: 4884 QITGTPKIRVSWYLDG-------NEITAIQKHGISFIDGLATFQISGAR------VENSG 4930
Query: 207 RYLCKCPNE 215
Y+C+ N+
Sbjct: 4931 TYVCEARND 4939
Score = 36.6 bits (83), Expect = 0.074
Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 8/120 (6%)
Query: 23 KPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLR------FKWFKNGNE 76
K ++ GS + +LKE S S V+ E + +S+ +W K E
Sbjct: 5590 KAQNEVGSDTCVCTVKLKEPPRFVSKLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEE 5649
Query: 77 LNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 136
+ R++ +NI+I + L+ KA A++G+Y+C++ + G A + ++E I+
Sbjct: 5650 VIRES--ENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPAVIV 5707
Score = 36.6 bits (83), Expect = 0.074
Identities = 38/177 (21%), Positives = 69/177 (38%), Gaps = 11/177 (6%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK + G ++L T + + W K+G + K + +K L
Sbjct: 5989 LKRLSDHSVEPGKSIILE-STYTGTLPISVTWKKDGFNITTSEKCNIVTTEKT---CILE 6044
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISV 158
I ++ D+G+Y C++ ++ G D A ++ +E +T + E A S +S+
Sbjct: 6045 ILNSTKRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTEL-EPLEAAVGDS-----VSL 6098
Query: 159 STEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVK-DLSNPSRYLCKCPN 214
+ A T T + G + L E F N K ++++ Y CK N
Sbjct: 6099 QCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAEN 6155
Score = 36.2 bits (82), Expect = 0.096
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +TI
Sbjct: 32885 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 32941
Score = 35.4 bits (80), Expect = 0.16
Identities = 41/184 (22%), Positives = 73/184 (39%), Gaps = 17/184 (9%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P +K ++ + G+ +L+CE S WFK+ ++ R +K + QK
Sbjct: 3831 PSFIKTLEPADIVRGTNALLQCEVSGT-GPFEISWFKDKKQI-RSSKKYRLFSQKS--LV 3886
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMP--ASTEGAYVSSESP 153
L I + AD GEY C V +++G A + E + + + G V+ ++
Sbjct: 3887 CLEIFSFNSADVGEYECVVANEVGKCGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAA 3946
Query: 154 IRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKD--LSNPSRYLCK 211
+R S S + +++ K K NG ++ D +S +Y C
Sbjct: 3947 VR---------GSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCL 3997
Query: 212 CPNE 215
NE
Sbjct: 3998 AENE 4001
Score = 35.4 bits (80), Expect = 0.16
Identities = 22/80 (27%), Positives = 39/80 (48%), Gaps = 4/80 (5%)
Query: 50 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 109
G+ L C + L KWFK+G EL+ +K I K + L+I A ++D G
Sbjct: 6659 GNPFALECVVTGT-PELSAKWFKDGRELSADSKHHITFINK---VASLKIPCAEMSDKGL 6714
Query: 110 YMCKVISKLGNDSASANITI 129
Y +V + +G + + ++ +
Sbjct: 6715 YSFEVKNSVGKSNCTVSVHV 6734
Score = 35.4 bits (80), Expect = 0.16
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 40 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 82
K ++ Q G+ VL CE S E + + KWFKNG E+ + K
Sbjct: 12289 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 12329
Score = 34.7 bits (78), Expect = 0.28
Identities = 23/99 (23%), Positives = 40/99 (40%), Gaps = 4/99 (4%)
Query: 44 SQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKAS 103
S + A G +C + + ++ W K+ E+ N K+ + L + K
Sbjct: 7220 SVDLALGESGTFKCHVTGT-APIKITWAKDNREIRPGG---NYKMTLVENTATLTVLKVG 7275
Query: 104 LADSGEYMCKVISKLGNDSASANITIVESNEIITGMPAS 142
D+G+Y C + G DS SA + + E I + S
Sbjct: 7276 KGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPS 7314
Score = 34.3 bits (77), Expect = 0.37
Identities = 23/99 (23%), Positives = 41/99 (41%), Gaps = 5/99 (5%)
Query: 34 ALPPRL-KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKP 92
A+PP + +K+ G+ +L C+ + S + WF ++ K Q
Sbjct: 5797 AVPPSFTRRLKNTGGVLGASCILECKVAGS-SPISVAWFHEKTKIVSGAKYQTTF---SD 5852
Query: 93 GKSELRINKASLADSGEYMCKVISKLGNDSASANITIVE 131
L++N +D G Y C + G+D A +T+ E
Sbjct: 5853 NVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVLTVQE 5891
Score = 34.3 bits (77), Expect = 0.37
Identities = 34/164 (20%), Positives = 62/164 (37%), Gaps = 26/164 (15%)
Query: 67 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 126
+ WF+ EL + ++ I + +EL + ++ SGEY C V + G S +
Sbjct: 5923 KVNWFRGARELVKGDR---CNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTR 5979
Query: 127 ITIVE---------SNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTS 177
+ + E + + G E Y + PI ++ +G N ++S + T
Sbjct: 5980 LFVKEPAAFLKRLSDHSVEPGKSIILESTYTGT-LPISVTWKKDGFNITTSEKCNIVTT- 6037
Query: 178 HLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRC 221
EKT + + + +Y C+ NE D C
Sbjct: 6038 --------EKTCILE----ILNSTKRDAGQYSCEIENEAGRDVC 6069
Score = 34.3 bits (77), Expect = 0.37
Identities = 19/79 (24%), Positives = 35/79 (44%), Gaps = 3/79 (3%)
Query: 57 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
C+ + S + W+ +L K +I + G + L + + D G Y CKV++
Sbjct: 31589 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 31645
Query: 117 KLGNDSASANITIVESNEI 135
G DS+ A + + E+
Sbjct: 31646 DYGEDSSYAELFVKGVREV 31664
Score = 33.9 bits (76), Expect = 0.48
Identities = 27/104 (25%), Positives = 45/104 (43%), Gaps = 9/104 (8%)
Query: 49 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 107
AG +VL + + W K G ++ +P +I +I P S L I A+ D+
Sbjct: 20392 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 20447
Query: 108 GEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSE 151
GEY + G +T+++ + G P E + VS+E
Sbjct: 20448 GEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSAE 20487
Score = 33.5 bits (75), Expect = 0.62
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 67 RFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASAN 126
+ KWFK+ EL K I + S L + + +G+Y C V + +G+DS +
Sbjct: 5360 KIKWFKDDVELVSGPK---CFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTM 5416
Query: 127 ITIVESNEIITGMPAS 142
+ + E + + + AS
Sbjct: 5417 LLVTEPPKFVKKLEAS 5432
Score = 32.7 bits (73), Expect = 1.1
Identities = 20/82 (24%), Positives = 36/82 (43%), Gaps = 4/82 (4%)
Query: 50 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 109
G C+ + +R W+ +GNE+ K I G + +I+ A + +SG
Sbjct: 4876 GQSTTFECQITGT-PKIRVSWYLDGNEITAIQKHG---ISFIDGLATFQISGARVENSGT 4931
Query: 110 YMCKVISKLGNDSASANITIVE 131
Y+C+ + G S S + + E
Sbjct: 4932 YVCEARNDAGTASCSIELKVKE 4953
Score = 32.7 bits (73), Expect = 1.1
Identities = 15/66 (22%), Positives = 35/66 (53%), Gaps = 3/66 (4%)
Query: 66 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
++ W+K+ E+ +K ++ + L ++ S+ DSG+Y C+ + G+ S+S
Sbjct: 7335 IKVLWYKDETEIQESSK---FRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSST 7391
Query: 126 NITIVE 131
++ + E
Sbjct: 7392 SLKVKE 7397
Score = 32.7 bits (73), Expect = 1.1
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK+ + +E ++V CE ++E + KWF+N + +K I +K LR
Sbjct: 12646 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 12697
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
I A L D Y + + G + SA IVE ++
Sbjct: 12698 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 12734
Score = 32.7 bits (73), Expect = 1.1
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
++ ++ Q V C+ S E +++ KW++NG E+ K K +K L
Sbjct: 12826 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 12880
Query: 99 INKASLADSGEYMCKV 114
I L D EY C V
Sbjct: 12881 IKDCRLDDECEYACGV 12896
Score = 32.7 bits (73), Expect = 1.1
Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ +
Sbjct: 14420 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 14476
Query: 130 V 130
+
Sbjct: 14477 I 14477
Score = 32.0 bits (71), Expect = 1.8
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 40 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
K + Q A + V CE ++ S + +W ++G L N NI+ + K L I
Sbjct: 2624 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2678
Query: 100 NKASLADSGEYMCKV 114
L D GEY KV
Sbjct: 2679 AATKLDDIGEYTYKV 2693
Score = 31.6 bits (70), Expect = 2.4
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L
Sbjct: 2975 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 3026
Query: 99 INKASLADSGEY 110
I D+ +Y
Sbjct: 3027 IRNVHFGDAADY 3038
Score = 30.8 bits (68), Expect = 4.0
Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 69 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
+W +G L N+ +++ + G L A DSG C+ +K G D SA +
Sbjct: 1737 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1793
Query: 129 IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 169
+ + ++ + +P +G E ++ EGA T +T
Sbjct: 1794 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1833
Score = 30.8 bits (68), Expect = 4.0
Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)
Query: 67 RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 123
+ +W KN + + I ++ + K+EL I KA D G Y ++LG+
Sbjct: 15429 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 15488
Query: 124 SANITIVE-----SNEIITGMPASTEGAYVSSESPI 154
+ ++ + + N +T + A E Y++ ++P+
Sbjct: 15489 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 15522
Score = 30.4 bits (67), Expect = 5.3
Identities = 32/163 (19%), Positives = 65/163 (39%), Gaps = 16/163 (9%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P +K+++S S G + + W K+ +E+ + NI++ + +
Sbjct: 4486 PSFIKKIESTSSLRGGTAAFQATLKGSLP-ITVTWLKDSDEITEDD---NIRMTFENNVA 4541
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIVE---------SNEIITGMPASTEGA 146
L ++ + G+Y+C+ + G SA +++ E S ++ G PA+ +
Sbjct: 4542 SLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVK 4601
Query: 147 YVSSESPIRISVSTEGANTS--SSTSTSTTGTSHLVKCAEKEK 187
+ S I +G + S S T T ++K EK
Sbjct: 4602 F-SGTKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEK 4643
Score = 30.4 bits (67), Expect = 5.3
Identities = 40/185 (21%), Positives = 66/185 (35%), Gaps = 30/185 (16%)
Query: 50 GSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGE 109
G L C+ + L +W+K+G L K + K S LRI D+G
Sbjct: 5718 GETCTLECKVAGT-PELSVEWYKDGKLLTSSQKHKFSFYNKI---SSLRILSVERQDAGT 5773
Query: 110 YMCKVISKLGNDSASANITI------------VESNEIITGMPASTEGAYVSSESPIRIS 157
Y +V + +G S +A + + +++ + G E V+ SPI ++
Sbjct: 5774 YTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILE-CKVAGSSPISVA 5832
Query: 158 VSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFT 217
E S TT + ++ T +N D S+ Y C N
Sbjct: 5833 WFHEKTKIVSGAKYQTTFSDNVC-------TLQLNS------LDSSDMGNYTCVAANVAG 5879
Query: 218 GDRCQ 222
D C+
Sbjct: 5880 SDECR 5884
Score = 30.0 bits (66), Expect = 6.9
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK++ ++E + V E S + ++R KWFKN L + +++ +Q + +
Sbjct: 11935 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 11986
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 138
S+ D+ + + + S+ A +T++E + TG
Sbjct: 11987 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 12022
Score = 29.6 bits (65), Expect = 9.0
Identities = 16/63 (25%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Query: 69 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
KW K + + N+ + I +K +++L I + DSG Y C ++ G ++ N+
Sbjct: 8486 KWTKG--KWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQ 8543
Query: 129 IVE 131
+ E
Sbjct: 8544 VDE 8546
Score = 29.6 bits (65), Expect = 9.0
Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + +
Sbjct: 18235 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 18293
Query: 130 VE 131
++
Sbjct: 18294 LD 18295
Score = 29.6 bits (65), Expect = 9.0
Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Query: 35 LPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
+PP+++ + S S G L + C + E + W G +++ + + + I+
Sbjct: 33327 IPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDD 33384
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
+ L I D G Y + ++ G+DSA+ NI I
Sbjct: 33385 LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 56.2 bits (134), Expect = 9e-08
Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P + + +SQ G ++ CE S E S +WFKN ++ + N+ I +
Sbjct: 26829 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26884
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 148
L I AS++DSG+Y K + G SA+A++ ++ S E++ T S +G++
Sbjct: 26885 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 26943
Query: 149 SSESPIRISVSTEGANTSSSTSTSTTGTSHL 179
S +++S S + A+ SS +S+S + + +
Sbjct: 26944 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 26973
Score = 50.4 bits (119), Expect = 5e-06
Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 20 SGKKPESAAGSQSPALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELN 78
SGK SA + P +K +++ E A G CE S ++RF+WFK G E+
Sbjct: 4512 SGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIY 4570
Query: 79 RKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
+K I+ S L I + + D GEY CK ++ G+ S +A +T+
Sbjct: 4571 ESDK---CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4618
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 52 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 111
++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+
Sbjct: 5374 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5427
Query: 112 CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
C G D AN+T VE+ I P +V + I +S
Sbjct: 5428 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 5470
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 26/193 (13%)
Query: 57 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
CE S E + + KWFK+G E+ + K I K L INK L D EY C+V +
Sbjct: 6090 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 6144
Query: 117 KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGANT---SSSTST 171
S +T++E + T A+ E VS I++ VS GA
Sbjct: 6145 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGAEVIWYKGDEEI 6197
Query: 172 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY- 230
TG ++ K N L + Y C+ P+ T + + + +A+ +
Sbjct: 6198 IETGRYEILTEGRKRILVIQNA-------HLEDAGNYNCRLPSSRTDGKVKVHELAAEFI 6250
Query: 231 -KHLGIEFMEAEE 242
K +E +E E+
Sbjct: 6251 SKPQNLEILEGEK 6263
Score = 40.0 bits (92), Expect = 0.007
Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 5/113 (4%)
Query: 33 PALPPRLKE-MKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 91
P PP L +K+ G + L C S Y S W++ ++ + +I +
Sbjct: 893 PVTPPTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQ 948
Query: 92 PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
G + L I +A DSG + C +++ G S S + + S E A TE
Sbjct: 949 SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001
Score = 40.0 bits (92), Expect = 0.007
Identities = 32/135 (23%), Positives = 49/135 (36%), Gaps = 3/135 (2%)
Query: 10 KGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK 69
KG+G K +S P P LKE+K A G + E +
Sbjct: 3741 KGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VT 3799
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
WFK +L I G +N DSG Y+CK + LG + +A + +
Sbjct: 3800 WFKENKQLC--TSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3857
Query: 130 VESNEIITGMPASTE 144
+ + +T P +
Sbjct: 3858 LLEDTDMTDTPCKAK 3872
Score = 38.9 bits (89), Expect = 0.015
Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 2/103 (1%)
Query: 25 ESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 84
E AG PA P + + Q+ G +V C+ + W K+G L +
Sbjct: 1025 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-Y 1082
Query: 85 NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 127
+ K+ G+ +L I+ D+GEY V +K G SASA++
Sbjct: 1083 KVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 38.9 bits (89), Expect = 0.015
Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 92
PP++ + E+ SK + + E S LR K W+K+G +L Q
Sbjct: 26412 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26466
Query: 93 GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 149
G EL+IN + +D GEY+C++ + G + +E ++ + + + +
Sbjct: 26467 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 26526
Query: 150 SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 191
+ES + + SS TG ++ F V
Sbjct: 26527 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 26568
Score = 37.4 bits (85), Expect = 0.043
Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 15/152 (9%)
Query: 14 KKKERGSG--KKPESAAGS-QSPALPPR-LKEMK----SQESAAGSKLVLRCETSSEYSS 65
+K GSG K P+ A + Q A+P + +KE+K ++ GS + C S S+
Sbjct: 4784 RKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSP--ST 4841
Query: 66 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
W K+G+ + K + I K +L I L+D+GEY C + +LGN ++
Sbjct: 4842 AITTWMKDGSNIRESPKHRFIADGKD---RKLHIIDVQLSDAGEYTC--VLRLGNKEKTS 4896
Query: 126 NITIVESNEIITGMPASTEGAYVSSESPIRIS 157
+V + + E V P+ +S
Sbjct: 4897 TAKLVVEELPVRFVKTLEEEVTVVKGQPLYLS 4928
Score = 37.4 bits (85), Expect = 0.043
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W+K+G ++ + + + G +L IN + D EY +K G DS A +T+
Sbjct: 25418 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25477
Score = 36.2 bits (82), Expect = 0.096
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +TI
Sbjct: 26580 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26636
Score = 35.4 bits (80), Expect = 0.16
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 40 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 82
K ++ Q G+ VL CE S E + + KWFKNG E+ + K
Sbjct: 5984 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 6024
Score = 34.3 bits (77), Expect = 0.37
Identities = 19/79 (24%), Positives = 35/79 (44%), Gaps = 3/79 (3%)
Query: 57 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
C+ + S + W+ +L K +I + G + L + + D G Y CKV++
Sbjct: 25284 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 25340
Query: 117 KLGNDSASANITIVESNEI 135
G DS+ A + + E+
Sbjct: 25341 DYGEDSSYAELFVKGVREV 25359
Score = 33.9 bits (76), Expect = 0.48
Identities = 27/104 (25%), Positives = 45/104 (43%), Gaps = 9/104 (8%)
Query: 49 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 107
AG +VL + + W K G ++ +P +I +I P S L I A+ D+
Sbjct: 14087 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 14142
Query: 108 GEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSE 151
GEY + G +T+++ + G P E + VS+E
Sbjct: 14143 GEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSAE 14182
Score = 32.7 bits (73), Expect = 1.1
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK+ + +E ++V CE ++E + KWF+N + +K I +K LR
Sbjct: 6341 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6392
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
I A L D Y + + G + SA IVE ++
Sbjct: 6393 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 6429
Score = 32.7 bits (73), Expect = 1.1
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
++ ++ Q V C+ S E +++ KW++NG E+ K K +K L
Sbjct: 6521 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6575
Query: 99 INKASLADSGEYMCKV 114
I L D EY C V
Sbjct: 6576 IKDCRLDDECEYACGV 6591
Score = 32.7 bits (73), Expect = 1.1
Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ +
Sbjct: 8115 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8171
Query: 130 V 130
+
Sbjct: 8172 I 8172
Score = 32.0 bits (71), Expect = 1.8
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 40 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
K + Q A + V CE ++ S + +W ++G L N NI+ + K L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632
Query: 100 NKASLADSGEYMCKV 114
L D GEY KV
Sbjct: 2633 AATKLDDIGEYTYKV 2647
Score = 31.6 bits (70), Expect = 2.4
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980
Query: 99 INKASLADSGEY 110
I D+ +Y
Sbjct: 2981 IRNVHFGDAADY 2992
Score = 30.8 bits (68), Expect = 4.0
Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 69 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
+W +G L N+ +++ + G L A DSG C+ +K G D SA +
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747
Query: 129 IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 169
+ + ++ + +P +G E ++ EGA T +T
Sbjct: 1748 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1787
Score = 30.8 bits (68), Expect = 4.0
Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)
Query: 67 RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 123
+ +W KN + + I ++ + K+EL I KA D G Y ++LG+
Sbjct: 9124 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 9183
Query: 124 SANITIVE-----SNEIITGMPASTEGAYVSSESPI 154
+ ++ + + N +T + A E Y++ ++P+
Sbjct: 9184 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 9217
Score = 30.0 bits (66), Expect = 6.9
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK++ ++E + V E S + ++R KWFKN L + +++ +Q + +
Sbjct: 5630 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 5681
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 138
S+ D+ + + + S+ A +T++E + TG
Sbjct: 5682 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 5717
Score = 29.6 bits (65), Expect = 9.0
Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + +
Sbjct: 11930 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11988
Query: 130 VE 131
++
Sbjct: 11989 LD 11990
Score = 29.6 bits (65), Expect = 9.0
Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Query: 35 LPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
+PP+++ + S S G L + C + E + W G +++ + + + I+
Sbjct: 27022 IPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDD 27079
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
+ L I D G Y + ++ G+DSA+ NI I
Sbjct: 27080 LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27115
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 56.2 bits (134), Expect = 9e-08
Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P + + +SQ G ++ CE S E S +WFKN ++ + N+ I +
Sbjct: 26762 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26817
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 148
L I AS++DSG+Y K + G SA+A++ ++ S E++ T S +G++
Sbjct: 26818 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 26876
Query: 149 SSESPIRISVSTEGANTSSSTSTSTTGTSHL 179
S +++S S + A+ SS +S+S + + +
Sbjct: 26877 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 26906
Score = 50.4 bits (119), Expect = 5e-06
Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 20 SGKKPESAAGSQSPALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELN 78
SGK SA + P +K +++ E A G CE S ++RF+WFK G E+
Sbjct: 4445 SGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIY 4503
Query: 79 RKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
+K I+ S L I + + D GEY CK ++ G+ S +A +T+
Sbjct: 4504 ESDK---CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4551
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 52 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 111
++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+
Sbjct: 5307 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5360
Query: 112 CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
C G D AN+T VE+ I P +V + I +S
Sbjct: 5361 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 5403
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 26/193 (13%)
Query: 57 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
CE S E + + KWFK+G E+ + K I K L INK L D EY C+V +
Sbjct: 6023 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 6077
Query: 117 KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGANT---SSSTST 171
S +T++E + T A+ E VS I++ VS GA
Sbjct: 6078 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGAEVIWYKGDEEI 6130
Query: 172 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY- 230
TG ++ K N L + Y C+ P+ T + + + +A+ +
Sbjct: 6131 IETGRYEILTEGRKRILVIQNA-------HLEDAGNYNCRLPSSRTDGKVKVHELAAEFI 6183
Query: 231 -KHLGIEFMEAEE 242
K +E +E E+
Sbjct: 6184 SKPQNLEILEGEK 6196
Score = 40.0 bits (92), Expect = 0.007
Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 5/113 (4%)
Query: 33 PALPPRLKE-MKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 91
P PP L +K+ G + L C S Y S W++ ++ + +I +
Sbjct: 893 PVTPPTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQ 948
Query: 92 PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
G + L I +A DSG + C +++ G S S + + S E A TE
Sbjct: 949 SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001
Score = 40.0 bits (92), Expect = 0.007
Identities = 32/135 (23%), Positives = 49/135 (36%), Gaps = 3/135 (2%)
Query: 10 KGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK 69
KG+G K +S P P LKE+K A G + E +
Sbjct: 3674 KGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VT 3732
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
WFK +L I G +N DSG Y+CK + LG + +A + +
Sbjct: 3733 WFKENKQLC--TSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3790
Query: 130 VESNEIITGMPASTE 144
+ + +T P +
Sbjct: 3791 LLEDTDMTDTPCKAK 3805
Score = 38.9 bits (89), Expect = 0.015
Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 2/103 (1%)
Query: 25 ESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 84
E AG PA P + + Q+ G +V C+ + W K+G L +
Sbjct: 1025 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-Y 1082
Query: 85 NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 127
+ K+ G+ +L I+ D+GEY V +K G SASA++
Sbjct: 1083 KVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 38.9 bits (89), Expect = 0.015
Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 92
PP++ + E+ SK + + E S LR K W+K+G +L Q
Sbjct: 26345 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26399
Query: 93 GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 149
G EL+IN + +D GEY+C++ + G + +E ++ + + + +
Sbjct: 26400 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 26459
Query: 150 SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 191
+ES + + SS TG ++ F V
Sbjct: 26460 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 26501
Score = 37.4 bits (85), Expect = 0.043
Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 15/152 (9%)
Query: 14 KKKERGSG--KKPESAAGS-QSPALPPR-LKEMK----SQESAAGSKLVLRCETSSEYSS 65
+K GSG K P+ A + Q A+P + +KE+K ++ GS + C S S+
Sbjct: 4717 RKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSP--ST 4774
Query: 66 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
W K+G+ + K + I K +L I L+D+GEY C + +LGN ++
Sbjct: 4775 AITTWMKDGSNIRESPKHRFIADGKD---RKLHIIDVQLSDAGEYTC--VLRLGNKEKTS 4829
Query: 126 NITIVESNEIITGMPASTEGAYVSSESPIRIS 157
+V + + E V P+ +S
Sbjct: 4830 TAKLVVEELPVRFVKTLEEEVTVVKGQPLYLS 4861
Score = 37.4 bits (85), Expect = 0.043
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W+K+G ++ + + + G +L IN + D EY +K G DS A +T+
Sbjct: 25351 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25410
Score = 36.2 bits (82), Expect = 0.096
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +TI
Sbjct: 26513 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26569
Score = 35.4 bits (80), Expect = 0.16
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 40 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 82
K ++ Q G+ VL CE S E + + KWFKNG E+ + K
Sbjct: 5917 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 5957
Score = 34.3 bits (77), Expect = 0.37
Identities = 19/79 (24%), Positives = 35/79 (44%), Gaps = 3/79 (3%)
Query: 57 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
C+ + S + W+ +L K +I + G + L + + D G Y CKV++
Sbjct: 25217 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 25273
Query: 117 KLGNDSASANITIVESNEI 135
G DS+ A + + E+
Sbjct: 25274 DYGEDSSYAELFVKGVREV 25292
Score = 33.9 bits (76), Expect = 0.48
Identities = 27/104 (25%), Positives = 45/104 (43%), Gaps = 9/104 (8%)
Query: 49 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 107
AG +VL + + W K G ++ +P +I +I P S L I A+ D+
Sbjct: 14020 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 14075
Query: 108 GEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSE 151
GEY + G +T+++ + G P E + VS+E
Sbjct: 14076 GEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSAE 14115
Score = 32.7 bits (73), Expect = 1.1
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK+ + +E ++V CE ++E + KWF+N + +K I +K LR
Sbjct: 6274 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6325
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
I A L D Y + + G + SA IVE ++
Sbjct: 6326 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 6362
Score = 32.7 bits (73), Expect = 1.1
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
++ ++ Q V C+ S E +++ KW++NG E+ K K +K L
Sbjct: 6454 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6508
Query: 99 INKASLADSGEYMCKV 114
I L D EY C V
Sbjct: 6509 IKDCRLDDECEYACGV 6524
Score = 32.7 bits (73), Expect = 1.1
Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ +
Sbjct: 8048 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 8104
Query: 130 V 130
+
Sbjct: 8105 I 8105
Score = 32.0 bits (71), Expect = 1.8
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 40 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
K + Q A + V CE ++ S + +W ++G L N NI+ + K L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632
Query: 100 NKASLADSGEYMCKV 114
L D GEY KV
Sbjct: 2633 AATKLDDIGEYTYKV 2647
Score = 31.6 bits (70), Expect = 2.4
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980
Query: 99 INKASLADSGEY 110
I D+ +Y
Sbjct: 2981 IRNVHFGDAADY 2992
Score = 30.8 bits (68), Expect = 4.0
Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 69 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
+W +G L N+ +++ + G L A DSG C+ +K G D SA +
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747
Query: 129 IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 169
+ + ++ + +P +G E ++ EGA T +T
Sbjct: 1748 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1787
Score = 30.8 bits (68), Expect = 4.0
Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)
Query: 67 RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 123
+ +W KN + + I ++ + K+EL I KA D G Y ++LG+
Sbjct: 9057 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 9116
Query: 124 SANITIVE-----SNEIITGMPASTEGAYVSSESPI 154
+ ++ + + N +T + A E Y++ ++P+
Sbjct: 9117 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 9150
Score = 30.0 bits (66), Expect = 6.9
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK++ ++E + V E S + ++R KWFKN L + +++ +Q + +
Sbjct: 5563 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 5614
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 138
S+ D+ + + + S+ A +T++E + TG
Sbjct: 5615 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 5650
Score = 29.6 bits (65), Expect = 9.0
Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + +
Sbjct: 11863 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11921
Query: 130 VE 131
++
Sbjct: 11922 LD 11923
Score = 29.6 bits (65), Expect = 9.0
Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Query: 35 LPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
+PP+++ + S S G L + C + E + W G +++ + + + I+
Sbjct: 26955 IPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDD 27012
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
+ L I D G Y + ++ G+DSA+ NI I
Sbjct: 27013 LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 27048
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 56.2 bits (134), Expect = 9e-08
Identities = 41/151 (27%), Positives = 76/151 (50%), Gaps = 13/151 (8%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
P + + +SQ G ++ CE S E S +WFKN ++ + N+ I +
Sbjct: 26637 PAFISQPRSQNINEGQNVLFTCEISGEPSP-EIEWFKNNLPISISS---NVSISRSRNVY 26692
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIV-----ESNEII--TGMPASTEGAYV 148
L I AS++DSG+Y K + G SA+A++ ++ S E++ T S +G++
Sbjct: 26693 SLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQGSF- 26751
Query: 149 SSESPIRISVSTEGANTSSSTSTSTTGTSHL 179
S +++S S + A+ SS +S+S + + +
Sbjct: 26752 -SSQSVQMSASKQEASFSSFSSSSASSMTEM 26781
Score = 50.4 bits (119), Expect = 5e-06
Identities = 35/111 (31%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 20 SGKKPESAAGSQSPALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELN 78
SGK SA + P +K +++ E A G CE S ++RF+WFK G E+
Sbjct: 4320 SGKTATSAKLTVVKRAAPVIKRKIEPLEVALGHLAKFTCEIQSA-PNVRFQWFKAGREIY 4378
Query: 79 RKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
+K I+ S L I + + D GEY CK ++ G+ S +A +T+
Sbjct: 4379 ESDK---CSIRSSKYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTV 4426
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/108 (31%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 52 KLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYM 111
++ L+CE S + + KWFK+G E+ K I+ + L+I KA L D GEY+
Sbjct: 5182 EITLKCEVSKD---VPVKWFKDGEEIVPSPK---YSIKADGLRRILKIKKADLKDKGEYV 5235
Query: 112 CKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVS 159
C G D AN+T VE+ I P +V + I +S
Sbjct: 5236 C----DCGTDKTKANVT-VEARLIKVEKPLYGVEVFVGETAHFEIELS 5278
Score = 44.7 bits (104), Expect = 3e-04
Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 26/193 (13%)
Query: 57 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
CE S E + + KWFK+G E+ + K I K L INK L D EY C+V +
Sbjct: 5898 CELSRE--NAKVKWFKDGAEIKKGKK---YDIISKGAVRILVINKCLLDDEAEYSCEVRT 5952
Query: 117 KLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRI--SVSTEGANT---SSSTST 171
S +T++E + T A+ E VS I++ VS GA
Sbjct: 5953 A----RTSGMLTVLEEEAVFTKNLANIE---VSETDTIKLVCEVSKPGAEVIWYKGDEEI 6005
Query: 172 STTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFY- 230
TG ++ K N L + Y C+ P+ T + + + +A+ +
Sbjct: 6006 IETGRYEILTEGRKRILVIQNA-------HLEDAGNYNCRLPSSRTDGKVKVHELAAEFI 6058
Query: 231 -KHLGIEFMEAEE 242
K +E +E E+
Sbjct: 6059 SKPQNLEILEGEK 6071
Score = 40.0 bits (92), Expect = 0.007
Identities = 29/113 (25%), Positives = 47/113 (41%), Gaps = 5/113 (4%)
Query: 33 PALPPRLKE-MKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKK 91
P PP L +K+ G + L C S Y S W++ ++ + +I +
Sbjct: 893 PVTPPTLVSGLKNVTVIEGESVTLECHISG-YPSPTVTWYREDYQIESSI---DFQITFQ 948
Query: 92 PGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTE 144
G + L I +A DSG + C +++ G S S + + S E A TE
Sbjct: 949 SGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1001
Score = 40.0 bits (92), Expect = 0.007
Identities = 32/135 (23%), Positives = 49/135 (36%), Gaps = 3/135 (2%)
Query: 10 KGKGKKKERGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK 69
KG+G K +S P P LKE+K A G + E +
Sbjct: 3549 KGEGHKDTETESAVAKSLEKLGGPCPPHFLKELKPIRCAQGLPAIFEYTVVGEPAPT-VT 3607
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
WFK +L I G +N DSG Y+CK + LG + +A + +
Sbjct: 3608 WFKENKQLC--TSVYYTIIHNPNGSGTFIVNDPQREDSGLYICKAENMLGESTCAAELLV 3665
Query: 130 VESNEIITGMPASTE 144
+ + +T P +
Sbjct: 3666 LLEDTDMTDTPCKAK 3680
Score = 38.9 bits (89), Expect = 0.015
Identities = 29/103 (28%), Positives = 46/103 (44%), Gaps = 2/103 (1%)
Query: 25 ESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQ 84
E AG PA P + + Q+ G +V C+ + W K+G L +
Sbjct: 1025 EEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVY-WKKSGVPLTTGYR-Y 1082
Query: 85 NIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANI 127
+ K+ G+ +L I+ D+GEY V +K G SASA++
Sbjct: 1083 KVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1125
Score = 38.9 bits (89), Expect = 0.015
Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFK---WFKNGNELNRKNKPQNIKIQKKP 92
PP++ + E+ SK + + E S LR K W+K+G +L Q
Sbjct: 26220 PPKITQFLKAEA---SKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFH--YSAD 26274
Query: 93 GKSELRINKASLADSGEYMCKVISKLGNDSASANI---TIVESNEIITGMPASTEGAYVS 149
G EL+IN + +D GEY+C++ + G + +E ++ + + + +
Sbjct: 26275 GTYELKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKT 26334
Query: 150 SESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCV 191
+ES + + SS TG ++ F V
Sbjct: 26335 TESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAV 26376
Score = 37.4 bits (85), Expect = 0.043
Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 15/152 (9%)
Query: 14 KKKERGSG--KKPESAAGS-QSPALPPR-LKEMK----SQESAAGSKLVLRCETSSEYSS 65
+K GSG K P+ A + Q A+P + +KE+K ++ GS + C S S+
Sbjct: 4592 RKLRPGSGGEKPPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSP--ST 4649
Query: 66 LRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASA 125
W K+G+ + K + I K +L I L+D+GEY C + +LGN ++
Sbjct: 4650 AITTWMKDGSNIRESPKHRFIADGKD---RKLHIIDVQLSDAGEYTC--VLRLGNKEKTS 4704
Query: 126 NITIVESNEIITGMPASTEGAYVSSESPIRIS 157
+V + + E V P+ +S
Sbjct: 4705 TAKLVVEELPVRFVKTLEEEVTVVKGQPLYLS 4736
Score = 37.4 bits (85), Expect = 0.043
Identities = 16/60 (26%), Positives = 28/60 (46%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W+K+G ++ + + + G +L IN + D EY +K G DS A +T+
Sbjct: 25226 WYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTV 25285
Score = 36.2 bits (82), Expect = 0.096
Identities = 20/60 (33%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+G + + K K+ + G L I+K +DSG Y C V + G+ S+S +TI
Sbjct: 26388 WTKDGKAITQGGK---YKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTI 26444
Score = 35.4 bits (80), Expect = 0.16
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 2/43 (4%)
Query: 40 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNK 82
K ++ Q G+ VL CE S E + + KWFKNG E+ + K
Sbjct: 5792 KPLEDQTVEEGATAVLECEVSRE--NAKVKWFKNGTEILKSKK 5832
Score = 34.3 bits (77), Expect = 0.37
Identities = 19/79 (24%), Positives = 35/79 (44%), Gaps = 3/79 (3%)
Query: 57 CETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVIS 116
C+ + S + W+ +L K +I + G + L + + D G Y CKV++
Sbjct: 25092 CKIENYDQSTQVTWYFGVRQLENSEK---YEITYEDGVAILYVKDITKLDDGTYRCKVVN 25148
Query: 117 KLGNDSASANITIVESNEI 135
G DS+ A + + E+
Sbjct: 25149 DYGEDSSYAELFVKGVREV 25167
Score = 33.9 bits (76), Expect = 0.48
Identities = 27/104 (25%), Positives = 45/104 (43%), Gaps = 9/104 (8%)
Query: 49 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNI-KIQKKPGKSELRINKASLADS 107
AG +VL + + W K G ++ +P +I +I P S L I A+ D+
Sbjct: 13895 AGDTIVLNAISILGKPLPKSSWSKAGKDI----RPSDITQITSTPTSSMLTIKYATRKDA 13950
Query: 108 GEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSE 151
GEY + G +T+++ + G P E + VS+E
Sbjct: 13951 GEYTITATNPFGTKVEHVKVTVLD----VPGPPGPVEISNVSAE 13990
Score = 32.7 bits (73), Expect = 1.1
Identities = 27/97 (27%), Positives = 44/97 (45%), Gaps = 8/97 (8%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK+ + +E ++V CE ++E + KWF+N + +K I +K LR
Sbjct: 6149 LKDTRVKEQ---QEVVFNCEVNTE--GAKAKWFRNEEAIFDSSK---YIILQKDLVYTLR 6200
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
I A L D Y + + G + SA IVE ++
Sbjct: 6201 IRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDL 6237
Score = 32.7 bits (73), Expect = 1.1
Identities = 21/76 (27%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
++ ++ Q V C+ S E +++ KW++NG E+ K K +K L
Sbjct: 6329 VEHLEDQTVTEFDDAVFSCQLSREKANV--KWYRNGREIKEGKK---YKFEKDGSIHRLI 6383
Query: 99 INKASLADSGEYMCKV 114
I L D EY C V
Sbjct: 6384 IKDCRLDDECEYACGV 6399
Score = 32.7 bits (73), Expect = 1.1
Identities = 16/61 (26%), Positives = 34/61 (55%), Gaps = 3/61 (4%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+G E+ ++ + ++ + L + K+ AD+G Y + +KLG+ +AS N+ +
Sbjct: 7923 WHKDGKEVKASDR---LTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKV 7979
Query: 130 V 130
+
Sbjct: 7980 I 7980
Score = 32.0 bits (71), Expect = 1.8
Identities = 23/75 (30%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 40 KEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRI 99
K + Q A + V CE ++ S + +W ++G L N NI+ + K L I
Sbjct: 2578 KPLTDQTVAESQEAVFECEVANPDS--KGEWLRDGKHLPLTN---NIRSESDGHKRRLII 2632
Query: 100 NKASLADSGEYMCKV 114
L D GEY KV
Sbjct: 2633 AATKLDDIGEYTYKV 2647
Score = 31.6 bits (70), Expect = 2.4
Identities = 19/72 (26%), Positives = 33/72 (45%), Gaps = 8/72 (11%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK++ ++E K + E + Y + +KW KNG E+ +K Q ++ K L
Sbjct: 2929 LKDINAEE-----KDTITFEVTVNYEGISYKWLKNGVEIKSTDKCQ---MRTKKLTHSLN 2980
Query: 99 INKASLADSGEY 110
I D+ +Y
Sbjct: 2981 IRNVHFGDAADY 2992
Score = 30.8 bits (68), Expect = 4.0
Identities = 24/103 (23%), Positives = 44/103 (42%), Gaps = 8/103 (7%)
Query: 69 KWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANIT 128
+W +G L N+ +++ + G L A DSG C+ +K G D SA +
Sbjct: 1691 EWLHDGKPLEAANR---LRMINEFGYCSLDYGVAYSRDSGIITCRATNKYGTDHTSATLI 1747
Query: 129 IVESNEII--TGMPASTEGAYVSSESPIRISVSTEGANTSSST 169
+ + ++ + +P +G E ++ EGA T +T
Sbjct: 1748 VKDEKSLVEESQLPEGRKGLQRIEELE---RMAHEGALTGVTT 1787
Score = 30.8 bits (68), Expect = 4.0
Identities = 21/96 (21%), Positives = 44/96 (45%), Gaps = 10/96 (10%)
Query: 67 RFKWFKNGNELNRKNKPQNI---KIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSA 123
+ +W KN + + I ++ + K+EL I KA D G Y ++LG+
Sbjct: 8932 KIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGSVFR 8991
Query: 124 SANITIVE-----SNEIITGMPASTEGAYVSSESPI 154
+ ++ + + N +T + A E Y++ ++P+
Sbjct: 8992 NVHVEVYDRPSPPRNLAVTDIKA--ESCYLTWDAPL 9025
Score = 30.0 bits (66), Expect = 6.9
Identities = 22/100 (22%), Positives = 47/100 (47%), Gaps = 12/100 (12%)
Query: 39 LKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELR 98
LK++ ++E + V E S + ++R KWFKN L + +++ +Q + +
Sbjct: 5438 LKDVTAKEKESA---VFTVELS--HDNIRVKWFKNDQRL---HTTRSVSMQDEGKTHSIT 5489
Query: 99 INKASLADSGEYMCKVISKLGNDSASANITIVESNEIITG 138
S+ D+ + + + S+ A +T++E + TG
Sbjct: 5490 FKDLSIDDTSQIRVEAMGM----SSEAKLTVLEGDPYFTG 5525
Score = 29.6 bits (65), Expect = 9.0
Identities = 14/62 (22%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 70 WFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
W K+ + + P+ +KI + S+ + KA +D G+Y+ + G+ A A + +
Sbjct: 11738 WTKDKDATDLTRSPR-VKIDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNV 11796
Query: 130 VE 131
++
Sbjct: 11797 LD 11798
Score = 29.6 bits (65), Expect = 9.0
Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 3/96 (3%)
Query: 35 LPPRLKEMKSQESA-AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPG 93
+PP+++ + S S G L + C + E + W G +++ + + + I+
Sbjct: 26830 IPPKIEALPSDISIDEGKVLTVACAFTGEPTP-EVTWSCGGRKIHSQEQGR-FHIENTDD 26887
Query: 94 KSELRINKASLADSGEYMCKVISKLGNDSASANITI 129
+ L I D G Y + ++ G+DSA+ NI I
Sbjct: 26888 LTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 26923
>gi|93102361 palladin [Homo sapiens]
Length = 1106
Score = 53.1 bits (126), Expect = 8e-07
Identities = 55/196 (28%), Positives = 87/196 (44%), Gaps = 22/196 (11%)
Query: 18 RGSGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNEL 77
R S +P SA PA P +++++SQE A GS++ L C + + R +WF G EL
Sbjct: 255 RKSHPQPHSAL--HFPAAPRFIQKLRSQEVAEGSRVYLECRVTGN-PTPRVRWFCEGKEL 311
Query: 78 NRKNKPQNIKIQKKPGK-SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEII 136
+ N P +I+I + G L I +A D+G Y C + G+D+ SA + I
Sbjct: 312 H--NTP-DIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVFI------- 361
Query: 137 TGMPASTEGA-YVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGE 195
EGA S+S S GA + T++ + + T V
Sbjct: 362 -------EGASSTDSDSESLAFKSRAGAMPQAQKKTTSVSLTIGSSSPKTGVTTAVIQPL 414
Query: 196 CFMVKDLSNPSRYLCK 211
V+ + +P+ YLC+
Sbjct: 415 SVPVQQVHSPTSYLCR 430
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 51.2 bits (121), Expect = 3e-06
Identities = 36/137 (26%), Positives = 66/137 (48%), Gaps = 20/137 (14%)
Query: 25 ESAAGSQSPALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 83
+ + S P++ P ++ E S G L L C + + ++ W+K G L +++
Sbjct: 2618 QGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAI-ITWYKRGGSLPSRHQT 2676
Query: 84 QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPAST 143
S LR+++ S+ADSGEY+C+ A+ NI +E++ +I+ P++
Sbjct: 2677 HG---------SHLRLHQMSVADSGEYVCR---------ANNNIDALEASIVISVSPSAG 2718
Query: 144 EGAYVSSESPIRISVST 160
+ S PIRI S+
Sbjct: 2719 SPSAPGSSMPIRIESSS 2735
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/137 (30%), Positives = 60/137 (43%), Gaps = 20/137 (14%)
Query: 27 AAGSQSP---ALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKP 83
+AGS S ++P R+ E S A G L L C + + + W K G L ++
Sbjct: 2716 SAGSPSAPGSSMPIRI-ESSSSHVAEGETLDLNCVVPGQ-AHAQVTWHKRGGSLPSHHQT 2773
Query: 84 QNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPAST 143
+ S LR++ S ADSGEY+C+V+ G AS +TI S +PA
Sbjct: 2774 RG---------SRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAP- 2823
Query: 144 EGAYVSSESPIRISVST 160
PIRI S+
Sbjct: 2824 -----GGAPPIRIEPSS 2835
Score = 47.0 bits (110), Expect = 5e-05
Identities = 41/135 (30%), Positives = 61/135 (45%), Gaps = 22/135 (16%)
Query: 30 SQSPALPPRLK-EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 88
S S A PP +K E S G L L C + + + W++ G L P + ++
Sbjct: 2044 SASDASPPPVKIESSSPSVTEGQTLDLNCVVAGS-AHAQVTWYRRGGSL-----PPHTQV 2097
Query: 89 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIV---ESNEIITGMPASTEG 145
S LR+ + S ADSGEY+C+V + G AS ++++ S T +P ST
Sbjct: 2098 HG----SRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTR- 2152
Query: 146 AYVSSESPIRISVST 160
PIRI S+
Sbjct: 2153 -------PIRIEPSS 2160
Score = 47.0 bits (110), Expect = 5e-05
Identities = 41/139 (29%), Positives = 62/139 (44%), Gaps = 13/139 (9%)
Query: 26 SAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQN 85
S + SQ A P R+ E S A G L L C +S+ + W+K G L +++
Sbjct: 2525 SGSHSQGVAYPVRI-ESSSASLANGHTLDLNCLVASQ-APHTITWYKRGGSLPSRHQIVG 2582
Query: 86 IKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEG 145
S LRI + + ADSGEY+C V + G+ S +TI S + +P+ +
Sbjct: 2583 ---------SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS--SHVPSVSPP 2631
Query: 146 AYVSSESPIRISVSTEGAN 164
+ S SP + T N
Sbjct: 2632 IRIESSSPTVVEGQTLDLN 2650
Score = 46.6 bits (109), Expect = 7e-05
Identities = 34/117 (29%), Positives = 49/117 (41%), Gaps = 10/117 (8%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
PP E S A G L L+C + + + W K G L +++
Sbjct: 2827 PPIRIEPSSSRVAEGQTLDLKCVVPGQ-AHAQVTWHKRGGNLPARHQVHG---------P 2876
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSES 152
LR+N+ S ADSGEY C+V G AS +TI S+ P + Y+ + S
Sbjct: 2877 LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASS 2933
Score = 44.3 bits (103), Expect = 4e-04
Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 10/89 (11%)
Query: 41 EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRIN 100
E S + A G L L C + + + + W K G L +++ S LR+
Sbjct: 2442 ESSSSQVAEGQTLDLNCLVAGQ-AHAQVTWHKRGGSLPARHQVHG---------SRLRLL 2491
Query: 101 KASLADSGEYMCKVISKLGNDSASANITI 129
+ + ADSGEY+C+V+ G AS +TI
Sbjct: 2492 QVTPADSGEYVCRVVGSSGTQEASVLVTI 2520
Score = 42.4 bits (98), Expect = 0.001
Identities = 34/126 (26%), Positives = 56/126 (44%), Gaps = 20/126 (15%)
Query: 35 LPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGK 94
+PP E S A G L L C + + + + W+K G L +++ +
Sbjct: 2244 IPPVRIESSSSTVAEGQTLDLSCVVAGQ-AHAQVTWYKRGGSLPARHQVRG--------- 2293
Query: 95 SELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPI 154
S L I +AS AD+G+Y+C+ ++ A+IT+ +TG + S PI
Sbjct: 2294 SRLYIFQASPADAGQYVCR-----ASNGMEASITVT-----VTGTQGANLAYPAGSTQPI 2343
Query: 155 RISVST 160
RI S+
Sbjct: 2344 RIEPSS 2349
Score = 40.8 bits (94), Expect = 0.004
Identities = 32/112 (28%), Positives = 48/112 (42%), Gaps = 12/112 (10%)
Query: 23 KPESAAGSQSPALP-PRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKN 81
+P S +P L P E S G L L C + + + W+K G L ++
Sbjct: 2911 EPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQ-AHAQVTWYKRGGSLPARH 2969
Query: 82 KPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLG-NDSASANITIVES 132
+ S+LR++ S ADSGEY+C+ S G AS +T+ S
Sbjct: 2970 QTHG---------SQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPS 3012
Score = 40.8 bits (94), Expect = 0.004
Identities = 20/49 (40%), Positives = 26/49 (53%), Gaps = 7/49 (14%)
Query: 175 GTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQN 223
G SH C ++ C NGG+C S S Y+C CP FTG RC++
Sbjct: 3841 GISHCPTCRDRP---CQNGGQCHD----SESSSYVCVCPAGFTGSRCEH 3882
Score = 40.4 bits (93), Expect = 0.005
Identities = 29/95 (30%), Positives = 43/95 (45%), Gaps = 10/95 (10%)
Query: 41 EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRIN 100
E S + A G L L C + S + W K G L +++ S LR+
Sbjct: 2346 EPSSSQVAEGQTLDLNCVVPGQ-SHAQVTWHKRGGSLPVRHQTHG---------SLLRLY 2395
Query: 101 KASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
+AS ADSGEY+C+V+ AS +TI + +
Sbjct: 2396 QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSV 2430
Score = 40.0 bits (92), Expect = 0.007
Identities = 28/92 (30%), Positives = 41/92 (44%), Gaps = 10/92 (10%)
Query: 41 EMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRIN 100
E S A G L L C + + + W K G L +++ S LR++
Sbjct: 2157 EPSSSHVAEGQTLDLNCVVPGQ-AHAQVTWHKRGGSLPARHQTHG---------SLLRLH 2206
Query: 101 KASLADSGEYMCKVISKLGNDSASANITIVES 132
+ + ADSGEY+C V+ G AS +TI S
Sbjct: 2207 QVTPADSGEYVCHVVGTSGPLEASVLVTIEAS 2238
Score = 35.8 bits (81), Expect = 0.13
Identities = 36/153 (23%), Positives = 61/153 (39%), Gaps = 26/153 (16%)
Query: 31 QSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQK 90
+SP + E S + AG + L+C L F+W + G+ L + +N
Sbjct: 3296 ESPPYATTVPEHASVQ--AGETVQLQCLAHGT-PPLTFQWSRVGSSLPGRATARN----- 3347
Query: 91 KPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSS 150
L +A+ DSG Y C+V +K+G+ A A + ++ G P S + +
Sbjct: 3348 ----ELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQL-------LVQGPPGSLPATSIPA 3396
Query: 151 ESPIRISVSTEGANTSSSTSTSTTGTSHLVKCA 183
S + V+ + T + G S CA
Sbjct: 3397 GSTPTVQVTPQ-------LETKSIGASVEFHCA 3422
Score = 32.0 bits (71), Expect = 1.8
Identities = 22/104 (21%), Positives = 41/104 (39%), Gaps = 10/104 (9%)
Query: 45 QESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASL 104
+ + G+ + C S+ + + +WFK G +L + Q+ LRI
Sbjct: 3409 ETKSIGASVEFHCAVPSDRGT-QLRWFKEGGQLPPGHSVQD---------GVLRIQNLDQ 3458
Query: 105 ADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV 148
+ G Y+C+ G ASA + I ++ + S + V
Sbjct: 3459 SCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV 3502
Score = 30.0 bits (66), Expect = 6.9
Identities = 25/104 (24%), Positives = 42/104 (40%), Gaps = 14/104 (13%)
Query: 49 AGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSG 108
AG + L C + S W K G L + + + I + L I + AD+G
Sbjct: 1969 AGRTVRLYCRAAG-VPSATITWRKEGGSLPPQARSERTDI------ATLLIPAITTADAG 2021
Query: 109 EYMCKVISKLGNDSASANITIVESNE-------IITGMPASTEG 145
Y+C S G A + ++ +++ I + P+ TEG
Sbjct: 2022 FYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEG 2065
Score = 30.0 bits (66), Expect = 6.9
Identities = 32/134 (23%), Positives = 52/134 (38%), Gaps = 14/134 (10%)
Query: 29 GSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKI 88
G+ +P P E AG LRC + + W K + L +++ +
Sbjct: 3205 GAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPT-IHWSKLRSPLPWQHRLEG--- 3260
Query: 89 QKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYV 148
L I + + DSG+Y+C S G+ A+ I VES T +P E A V
Sbjct: 3261 ------DTLIIPRVAQQDSGQYICNATSPAGHAEATI-ILHVESPPYATTVP---EHASV 3310
Query: 149 SSESPIRISVSTEG 162
+ +++ G
Sbjct: 3311 QAGETVQLQCLAHG 3324
>gi|221316757 neurotrimin isoform 3 [Homo sapiens]
Length = 355
Score = 50.8 bits (120), Expect = 4e-06
Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 3/100 (3%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
PP + E K G K L+CE S+ S F+W+K+ L K +K++ +P S
Sbjct: 222 PPYISEAKGTGVPVGQKGTLQCEASA-VPSAEFQWYKDDKRLIEGKK--GVKVENRPFLS 278
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEI 135
+L S D G Y C +KLG+ +AS + V++ +
Sbjct: 279 KLIFFNVSEHDYGNYTCVASNKLGHTNASIMLFEVKTTAL 318
>gi|45594240 limbic system-associated membrane protein [Homo
sapiens]
Length = 338
Score = 50.8 bits (120), Expect = 4e-06
Identities = 27/89 (30%), Positives = 46/89 (51%), Gaps = 4/89 (4%)
Query: 36 PPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKS 95
PP + E KS E+ G + L+CE S+ + F+W+++ +N N ++I+ G+S
Sbjct: 218 PPTITESKSNEATTGRQASLKCEASA-VPAPDFEWYRDDTRINSAN---GLEIKSTEGQS 273
Query: 96 ELRINKASLADSGEYMCKVISKLGNDSAS 124
L + + G Y C +KLG +AS
Sbjct: 274 SLTVTNVTEEHYGNYTCVAANKLGVTNAS 302
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.124 0.352
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,967,466
Number of Sequences: 37866
Number of extensions: 1351325
Number of successful extensions: 9809
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 484
Number of HSP's that attempted gapping in prelim test: 7311
Number of HSP's gapped (non-prelim): 2838
length of query: 645
length of database: 18,247,518
effective HSP length: 109
effective length of query: 536
effective length of database: 14,120,124
effective search space: 7568386464
effective search space used: 7568386464
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.