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Search of human proteins with 23308751
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23308751 3-hydroxyisobutyrate dehydrogenase [Homo sapiens]
(336 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23308751 3-hydroxyisobutyrate dehydrogenase [Homo sapiens] 662 0.0
gi|40556376 cytokine-like nuclear factor n-pac [Homo sapiens] 110 2e-24
gi|40068518 phosphogluconate dehydrogenase [Homo sapiens] 40 0.003
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 33 0.36
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 32 0.61
gi|56699485 ligatin [Homo sapiens] 31 1.4
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 31 1.8
gi|61743967 C-terminal binding protein 1 isoform 2 [Homo sapiens] 30 2.3
gi|4557497 C-terminal binding protein 1 isoform 1 [Homo sapiens] 30 2.3
gi|145580578 C-terminal binding protein 2 isoform 1 [Homo sapiens] 30 4.0
gi|4557499 C-terminal binding protein 2 isoform 1 [Homo sapiens] 30 4.0
gi|145580575 C-terminal binding protein 2 isoform 2 [Homo sapiens] 30 4.0
gi|13540547 solute carrier family 2 member 10 [Homo sapiens] 30 4.0
gi|13375721 hypothetical protein LOC79607 [Homo sapiens] 30 4.0
gi|145699133 KPL2 protein isoform 1 [Homo sapiens] 29 6.8
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 28 8.9
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 28 8.9
>gi|23308751 3-hydroxyisobutyrate dehydrogenase [Homo sapiens]
Length = 336
Score = 662 bits (1708), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)
Query: 1 MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMK 60
MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMK
Sbjct: 1 MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMK 60
Query: 61 HGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGIL 120
HGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGIL
Sbjct: 61 HGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGIL 120
Query: 121 KKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVED 180
KKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVED
Sbjct: 121 KKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVED 180
Query: 181 EFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLL 240
EFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLL
Sbjct: 181 EFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLL 240
Query: 241 AKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPI 300
AKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPI
Sbjct: 241 AKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPI 300
Query: 301 LLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF 336
LLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF
Sbjct: 301 LLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF 336
>gi|40556376 cytokine-like nuclear factor n-pac [Homo sapiens]
Length = 553
Score = 110 bits (274), Expect = 2e-24
Identities = 77/304 (25%), Positives = 130/304 (42%), Gaps = 7/304 (2%)
Query: 25 AGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQ 84
A AV + +GF+GLG MG+ + NL+K G+ + +++ + C F G +
Sbjct: 253 AADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGAR 312
Query: 85 VVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELA 144
+ +PA+V D + A + G +G+L+ ++ G +D ST+D ELA
Sbjct: 313 LGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELA 372
Query: 145 KEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGT 204
+ + G F++APVSG + G L + G + MG + G VG
Sbjct: 373 QVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGN 432
Query: 205 GQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVM 264
+ NM+ M AE + L G + L ILN G+ S ++
Sbjct: 433 AAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILN--QGQLASIFLDQKCQNIL 490
Query: 265 DGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPILLGSLAHQIYRMMCAKGYSKKDFS 324
G N++ F + KDL LA + P + + A+++Y+ A S D S
Sbjct: 491 QG-----NFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMS 545
Query: 325 SVFQ 328
+V++
Sbjct: 546 AVYR 549
>gi|40068518 phosphogluconate dehydrogenase [Homo sapiens]
Length = 483
Score = 40.0 bits (92), Expect = 0.003
Identities = 40/191 (20%), Positives = 80/191 (41%), Gaps = 19/191 (9%)
Query: 38 SKTPVGFIGLGNMGNPMAKNLMKHGYPLIIY--------DVFPDACKEFQDAGEQVVSSP 89
++ + IGL MG + N+ HG+ + + D + K + G Q +
Sbjct: 2 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKEM 61
Query: 90 ADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEK 149
+K RII ++ A++ + ++ + G ++ID + + ++++
Sbjct: 62 VSKLKKPRRIILLVKAG-QAVDDF--IEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKA 118
Query: 150 MGAVFMDAPVSGGVGAARSGNLTFMVGGVEDEF----AAAQELLGCMGSNVVYC---GAV 202
G +F+ + VSGG AR G + M GG ++ + Q + +G+ C G
Sbjct: 119 KGILFVGSGVSGGEEGARYGP-SLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDE 177
Query: 203 GTGQAAKICNN 213
G G K+ +N
Sbjct: 178 GAGHFVKMVHN 188
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 33.1 bits (74), Expect = 0.36
Identities = 32/137 (23%), Positives = 58/137 (42%), Gaps = 19/137 (13%)
Query: 22 RPAAGSFAAVCSRSV--ASKTPVGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQ 79
R + AA C+ V A TP + L + + + G P +Y+V P + K +
Sbjct: 213 RKVGAALAAGCTVVVKPAEDTPFSALALAELAS-------QAGIPSGVYNVIPCSRKNAK 265
Query: 80 DAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILK-KVKKGSL----LIDSST 134
+ GE + + P +I T+ I + AN + + ++ G L + DS+
Sbjct: 266 EVGEAICTDPL-----VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSAN 320
Query: 135 IDPAVSKELAKEVEKMG 151
+D AV+ +A + G
Sbjct: 321 VDQAVAGAMASKFRNTG 337
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 32.3 bits (72), Expect = 0.61
Identities = 33/143 (23%), Positives = 59/143 (41%), Gaps = 18/143 (12%)
Query: 22 RPAAGSFAAVCSRSV--ASKTPVGFIGLGNMGNPMAKNL------MKHGYPLIIYDVFPD 73
R + AA C+ V A TP + L + +L + G P +Y+V P
Sbjct: 213 RKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPC 272
Query: 74 ACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILK-KVKKGSL---- 128
+ K ++ GE + + P +I T+ I + AN + + ++ G L
Sbjct: 273 SRKNAKEVGEAICTDPL-----VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFI 327
Query: 129 LIDSSTIDPAVSKELAKEVEKMG 151
+ DS+ +D AV+ +A + G
Sbjct: 328 VFDSANVDQAVAGAMASKFRNTG 350
>gi|56699485 ligatin [Homo sapiens]
Length = 584
Score = 31.2 bits (69), Expect = 1.4
Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 3/34 (8%)
Query: 234 GLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGV 267
GLDP +A IL RC +S T NP PG D +
Sbjct: 514 GLDPYSVAAILQQ---RCQASTTVNPAPGAKDSL 544
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 30.8 bits (68), Expect = 1.8
Identities = 36/118 (30%), Positives = 50/118 (42%), Gaps = 21/118 (17%)
Query: 72 PDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANG---------ILKK 122
P AC ++S + AE + RI+T+LP + ++ S A G KK
Sbjct: 655 PLACAAAAPLTSPSITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKK 714
Query: 123 VKKG--SLLIDSST-----IDPAVSKEL-----AKEVEKMGAVFMDAPVSGGVGAARS 168
KKG LL +ST + P S L + E+ GAV + P GG G A S
Sbjct: 715 EKKGLLKLLSGASTKRKPRVSPPASPTLEVELGSAELPLQGAVGPELPPGGGHGRAGS 772
>gi|61743967 C-terminal binding protein 1 isoform 2 [Homo sapiens]
Length = 429
Score = 30.4 bits (67), Expect = 2.3
Identities = 25/108 (23%), Positives = 54/108 (50%), Gaps = 3/108 (2%)
Query: 42 VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIIT 101
+G IGLG +G +A G+ ++ YD + E + G Q VS+ D+ +D +
Sbjct: 166 LGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVE-RALGLQRVSTLQDLLFHSDCV-- 222
Query: 102 MLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEK 149
L +N + + +K++++G+ L++++ K LA+ +++
Sbjct: 223 TLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKE 270
>gi|4557497 C-terminal binding protein 1 isoform 1 [Homo sapiens]
Length = 440
Score = 30.4 bits (67), Expect = 2.3
Identities = 25/108 (23%), Positives = 54/108 (50%), Gaps = 3/108 (2%)
Query: 42 VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIIT 101
+G IGLG +G +A G+ ++ YD + E + G Q VS+ D+ +D +
Sbjct: 177 LGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVE-RALGLQRVSTLQDLLFHSDCV-- 233
Query: 102 MLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEK 149
L +N + + +K++++G+ L++++ K LA+ +++
Sbjct: 234 TLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKE 281
>gi|145580578 C-terminal binding protein 2 isoform 1 [Homo sapiens]
Length = 445
Score = 29.6 bits (65), Expect = 4.0
Identities = 24/108 (22%), Positives = 53/108 (49%), Gaps = 3/108 (2%)
Query: 42 VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIIT 101
+G IG G G +A G+ +I YD + E + G Q V + D+ ++D +
Sbjct: 183 LGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIE-RSLGVQRVYTLQDLLYQSDCV-- 239
Query: 102 MLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEK 149
L ++N + + +K++++G+ L++++ K LA+ +++
Sbjct: 240 SLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKE 287
>gi|4557499 C-terminal binding protein 2 isoform 1 [Homo sapiens]
Length = 445
Score = 29.6 bits (65), Expect = 4.0
Identities = 24/108 (22%), Positives = 53/108 (49%), Gaps = 3/108 (2%)
Query: 42 VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIIT 101
+G IG G G +A G+ +I YD + E + G Q V + D+ ++D +
Sbjct: 183 LGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIE-RSLGVQRVYTLQDLLYQSDCV-- 239
Query: 102 MLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEK 149
L ++N + + +K++++G+ L++++ K LA+ +++
Sbjct: 240 SLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKE 287
>gi|145580575 C-terminal binding protein 2 isoform 2 [Homo sapiens]
Length = 985
Score = 29.6 bits (65), Expect = 4.0
Identities = 24/108 (22%), Positives = 53/108 (49%), Gaps = 3/108 (2%)
Query: 42 VGFIGLGNMGNPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIIT 101
+G IG G G +A G+ +I YD + E + G Q V + D+ ++D +
Sbjct: 723 LGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIE-RSLGVQRVYTLQDLLYQSDCV-- 779
Query: 102 MLPTSINAIEAYSGANGILKKVKKGSLLIDSSTIDPAVSKELAKEVEK 149
L ++N + + +K++++G+ L++++ K LA+ +++
Sbjct: 780 SLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKE 827
>gi|13540547 solute carrier family 2 member 10 [Homo sapiens]
Length = 541
Score = 29.6 bits (65), Expect = 4.0
Identities = 35/125 (28%), Positives = 47/125 (37%), Gaps = 2/125 (1%)
Query: 169 GNLTFMVGGVEDEFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMN 228
G T +G V + Q + C S + G +A + + L A+ + T AM
Sbjct: 230 GRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMG 289
Query: 229 LGIRLGLDPKLLAKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGL 288
L R G LLA M+ VP MD PS G T + D GL
Sbjct: 290 LVDRAGRRALLLAGCALMALSVSGIGLVSFAVP--MDSGPSCLAVPNATGQTGLPGDSGL 347
Query: 289 AQDSA 293
QDS+
Sbjct: 348 LQDSS 352
>gi|13375721 hypothetical protein LOC79607 [Homo sapiens]
Length = 351
Score = 29.6 bits (65), Expect = 4.0
Identities = 16/67 (23%), Positives = 32/67 (47%), Gaps = 2/67 (2%)
Query: 52 NPMAKNLMKHGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIE 111
+P N+ + +Y+VF D + +D+G+Q++ S + E ++T N +E
Sbjct: 112 SPRTSNVRSTFFKDCLYEVFDDLESKMEDSGKQLLQSVLHLMENGALVLT--TNFDNLLE 169
Query: 112 AYSGANG 118
Y+ G
Sbjct: 170 LYAADQG 176
>gi|145699133 KPL2 protein isoform 1 [Homo sapiens]
Length = 1822
Score = 28.9 bits (63), Expect = 6.8
Identities = 18/63 (28%), Positives = 32/63 (50%), Gaps = 4/63 (6%)
Query: 85 VVSSPADVAEKADRIITMLPTSINAI----EAYSGANGILKKVKKGSLLIDSSTIDPAVS 140
+V++ ++ D I+ P ++N EA +G N L +V++ + IDPA S
Sbjct: 709 IVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATS 768
Query: 141 KEL 143
KE+
Sbjct: 769 KEI 771
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 28.5 bits (62), Expect = 8.9
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 77 EFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTID 136
EF + +SSPA A A ++ ++ E G IL+++KK I SS +
Sbjct: 9 EFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVRAIHSSGLG 68
Query: 137 PAVSKELAKE-VEKMG 151
++E +E VE +G
Sbjct: 69 HVENEEQYREAVESLG 84
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 28.5 bits (62), Expect = 8.9
Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 1/76 (1%)
Query: 77 EFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGILKKVKKGSLLIDSSTID 136
EF + +SSPA A A ++ ++ E G IL+++KK I SS +
Sbjct: 9 EFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVRAIHSSGLG 68
Query: 137 PAVSKELAKE-VEKMG 151
++E +E VE +G
Sbjct: 69 HVENEEQYREAVESLG 84
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,725,348
Number of Sequences: 37866
Number of extensions: 503640
Number of successful extensions: 1074
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 1069
Number of HSP's gapped (non-prelim): 18
length of query: 336
length of database: 18,247,518
effective HSP length: 103
effective length of query: 233
effective length of database: 14,347,320
effective search space: 3342925560
effective search space used: 3342925560
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.