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Search of human proteins with 23308722
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23308722 TTK protein kinase [Homo sapiens]
(857 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23308722 TTK protein kinase [Homo sapiens] 1719 0.0
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 117 5e-26
gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2... 111 3e-24
gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2... 111 3e-24
gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2... 111 3e-24
gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2... 111 3e-24
gi|55956904 mitogen-activated protein kinase kinase kinase 4 iso... 109 9e-24
gi|55956902 mitogen-activated protein kinase kinase kinase 4 iso... 109 9e-24
gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens] 108 3e-23
gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens] 108 3e-23
gi|156105707 SNF related kinase [Homo sapiens] 107 5e-23
gi|156105705 SNF related kinase [Homo sapiens] 107 5e-23
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 107 5e-23
gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens] 106 8e-23
gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens] 106 8e-23
gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens] 106 8e-23
gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2... 105 2e-22
gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2... 105 2e-22
gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2... 105 2e-22
gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha ... 104 3e-22
gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha ... 104 3e-22
gi|121114283 polo-like kinase 4 [Homo sapiens] 103 5e-22
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 101 3e-21
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 101 3e-21
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 101 3e-21
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 100 1e-20
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 100 1e-20
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 100 1e-20
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 99 1e-20
gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha... 99 1e-20
>gi|23308722 TTK protein kinase [Homo sapiens]
Length = 857
Score = 1719 bits (4452), Expect = 0.0
Identities = 857/857 (100%), Positives = 857/857 (100%)
Query: 1 MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN 60
MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
Sbjct: 1 MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN 60
Query: 61 NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK 120
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
Sbjct: 61 NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK 120
Query: 121 AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML 180
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
Sbjct: 121 AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML 180
Query: 181 EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF 240
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
Sbjct: 181 EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF 240
Query: 241 LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ 300
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
Sbjct: 241 LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ 300
Query: 301 TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT 360
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
Sbjct: 301 TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT 360
Query: 361 ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ 420
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
Sbjct: 361 ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ 420
Query: 421 KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ 480
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
Sbjct: 421 KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ 480
Query: 481 LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF 540
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
Sbjct: 481 LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF 540
Query: 541 QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM 600
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
Sbjct: 541 QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM 600
Query: 601 VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML 660
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
Sbjct: 601 VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML 660
Query: 661 KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL 720
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
Sbjct: 661 KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL 720
Query: 721 GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI 780
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
Sbjct: 721 GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI 780
Query: 781 SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE 840
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
Sbjct: 781 SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE 840
Query: 841 SHNSSSSKTFEKKRGKK 857
SHNSSSSKTFEKKRGKK
Sbjct: 841 SHNSSSSKTFEKKRGKK 857
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 117 bits (293), Expect = 5e-26
Identities = 81/282 (28%), Positives = 143/282 (50%), Gaps = 28/282 (9%)
Query: 525 YSILKQIGSGGSSKVFQVLNEK--KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 582
+ + +++GSG + V++ +K +++ AIK V + + ++++ EI L ++
Sbjct: 14 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRH-- 71
Query: 583 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQH 641
I++L D++ IY++ME C DL+ ++ ++ + + + + + A+ +H+
Sbjct: 72 PHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHER 131
Query: 642 GIVHSDLKPANFLIVD---GMLKLIDFGIANQMQP-DTTSVVKDSQVGTVNYMPPEAIKD 697
I H DLKP N L+ LKL DFG A M P D V++ S + YM PE +
Sbjct: 132 NISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL----YMAPEMV-- 185
Query: 698 MSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFP 757
+ + + D+WS+G ILY +G+ PF S+L I N IE P
Sbjct: 186 ---------CQRQYDARVDLWSMGVILYEALFGQPPFAS--RSFSELEEKIRSNRVIELP 234
Query: 758 DIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 797
P +D +D+L+ L+RDP +RIS + AHP+V ++ P
Sbjct: 235 LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMP 276
>gi|27437017 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 2 [Homo sapiens]
Length = 541
Score = 111 bits (277), Expect = 3e-24
Identities = 87/339 (25%), Positives = 163/339 (48%), Gaps = 46/339 (13%)
Query: 482 STPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQ 541
S PY P Q ++ P ++ + +C+ + Y++ +IG G V
Sbjct: 125 SLPYS-PVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQ--YTLKDEIGKGSYGVVKL 181
Query: 542 VLNEKKQIY-AIKYVNLEEADNQT------------------------LDSYRNEIAYLN 576
NE Y A+K ++ ++ Q ++ EIA L
Sbjct: 182 AYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILK 241
Query: 577 KLQQHSD-KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 635
KL + K++ + D + + ++YMV E N + K + + + Y++++++ +
Sbjct: 242 KLDHPNVVKLVEVLD-DPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 636 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 694
+H I+H D+KP+N L+ DG +K+ DFG++N+ + + + + VGT +M PE+
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK--GSDALLSNTVGTPAFMAPES 358
Query: 695 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI 754
+S +R+ K+ DVW++G LY +G+ PF +I LH+ I + +
Sbjct: 359 ---LSETRKIFSGKA-----LDVWAMGVTLYCFVFGQCPFMD--ERIMCLHSKI-KSQAL 407
Query: 755 EFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
EFPD P+ +DL+D++ L ++P+ RI +PE+ HP+V
Sbjct: 408 EFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
>gi|27437015 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 1 [Homo sapiens]
Length = 588
Score = 111 bits (277), Expect = 3e-24
Identities = 87/339 (25%), Positives = 163/339 (48%), Gaps = 46/339 (13%)
Query: 482 STPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQ 541
S PY P Q ++ P ++ + +C+ + Y++ +IG G V
Sbjct: 125 SLPYS-PVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQ--YTLKDEIGKGSYGVVKL 181
Query: 542 VLNEKKQIY-AIKYVNLEEADNQT------------------------LDSYRNEIAYLN 576
NE Y A+K ++ ++ Q ++ EIA L
Sbjct: 182 AYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILK 241
Query: 577 KLQQHSD-KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 635
KL + K++ + D + + ++YMV E N + K + + + Y++++++ +
Sbjct: 242 KLDHPNVVKLVEVLD-DPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 636 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 694
+H I+H D+KP+N L+ DG +K+ DFG++N+ + + + + VGT +M PE+
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK--GSDALLSNTVGTPAFMAPES 358
Query: 695 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI 754
+S +R+ K+ DVW++G LY +G+ PF +I LH+ I + +
Sbjct: 359 ---LSETRKIFSGKA-----LDVWAMGVTLYCFVFGQCPFMD--ERIMCLHSKI-KSQAL 407
Query: 755 EFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
EFPD P+ +DL+D++ L ++P+ RI +PE+ HP+V
Sbjct: 408 EFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
>gi|27437027 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 2 [Homo sapiens]
Length = 541
Score = 111 bits (277), Expect = 3e-24
Identities = 87/339 (25%), Positives = 163/339 (48%), Gaps = 46/339 (13%)
Query: 482 STPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQ 541
S PY P Q ++ P ++ + +C+ + Y++ +IG G V
Sbjct: 125 SLPYS-PVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQ--YTLKDEIGKGSYGVVKL 181
Query: 542 VLNEKKQIY-AIKYVNLEEADNQT------------------------LDSYRNEIAYLN 576
NE Y A+K ++ ++ Q ++ EIA L
Sbjct: 182 AYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILK 241
Query: 577 KLQQHSD-KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 635
KL + K++ + D + + ++YMV E N + K + + + Y++++++ +
Sbjct: 242 KLDHPNVVKLVEVLD-DPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 636 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 694
+H I+H D+KP+N L+ DG +K+ DFG++N+ + + + + VGT +M PE+
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK--GSDALLSNTVGTPAFMAPES 358
Query: 695 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI 754
+S +R+ K+ DVW++G LY +G+ PF +I LH+ I + +
Sbjct: 359 ---LSETRKIFSGKA-----LDVWAMGVTLYCFVFGQCPFMD--ERIMCLHSKI-KSQAL 407
Query: 755 EFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
EFPD P+ +DL+D++ L ++P+ RI +PE+ HP+V
Sbjct: 408 EFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
>gi|27437021 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 5 [Homo sapiens]
Length = 533
Score = 111 bits (277), Expect = 3e-24
Identities = 87/339 (25%), Positives = 163/339 (48%), Gaps = 46/339 (13%)
Query: 482 STPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQ 541
S PY P Q ++ P ++ + +C+ + Y++ +IG G V
Sbjct: 125 SLPYS-PVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQ--YTLKDEIGKGSYGVVKL 181
Query: 542 VLNEKKQIY-AIKYVNLEEADNQT------------------------LDSYRNEIAYLN 576
NE Y A+K ++ ++ Q ++ EIA L
Sbjct: 182 AYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILK 241
Query: 577 KLQQHSD-KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 635
KL + K++ + D + + ++YMV E N + K + + + Y++++++ +
Sbjct: 242 KLDHPNVVKLVEVLD-DPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 636 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 694
+H I+H D+KP+N L+ DG +K+ DFG++N+ + + + + VGT +M PE+
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK--GSDALLSNTVGTPAFMAPES 358
Query: 695 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI 754
+S +R+ K+ DVW++G LY +G+ PF +I LH+ I + +
Sbjct: 359 ---LSETRKIFSGKA-----LDVWAMGVTLYCFVFGQCPFMD--ERIMCLHSKI-KSQAL 407
Query: 755 EFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
EFPD P+ +DL+D++ L ++P+ RI +PE+ HP+V
Sbjct: 408 EFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 446
>gi|55956904 mitogen-activated protein kinase kinase kinase 4 isoform
a [Homo sapiens]
Length = 1608
Score = 109 bits (273), Expect = 9e-24
Identities = 74/273 (27%), Positives = 145/273 (53%), Gaps = 22/273 (8%)
Query: 530 QIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRL 588
+IG G KV+ ++ + ++ A+K + + D++T+ +E+ ++ + ++R
Sbjct: 1348 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN--LVRY 1405
Query: 589 YDYEITDQYIYMVMEC---GNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVH 645
+ E+ + +Y+ ME G ++ S L ++ + + Y K + A++ +H+HGIVH
Sbjct: 1406 FGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI----RLYSKQITIAINVLHEHGIVH 1461
Query: 646 SDLKPAN-FLIVDGMLKLIDFGIANQMQPDTTSVVKD--SQVGTVNYMPPEAIKDMSSSR 702
D+K AN FL G++KL DFG + +++ + ++ + S +GT YM PE I +R
Sbjct: 1462 RDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-----TR 1516
Query: 703 ENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEK 762
G+ + +D+WSLGC++ M GK P+ + + ++ + H+ P+
Sbjct: 1517 AKGEGHGR---AADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYK-VGMGHKPPIPERLSP 1572
Query: 763 DLQDVLKCCLKRDPKQRISIPELLAHPYVQIQT 795
+ +D L CL+ DPK R + +LL H +V++ T
Sbjct: 1573 EGKDFLSHCLESDPKMRWTASQLLDHSFVKVCT 1605
>gi|55956902 mitogen-activated protein kinase kinase kinase 4 isoform
b [Homo sapiens]
Length = 1558
Score = 109 bits (273), Expect = 9e-24
Identities = 74/273 (27%), Positives = 145/273 (53%), Gaps = 22/273 (8%)
Query: 530 QIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRL 588
+IG G KV+ ++ + ++ A+K + + D++T+ +E+ ++ + ++R
Sbjct: 1298 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPN--LVRY 1355
Query: 589 YDYEITDQYIYMVMEC---GNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVH 645
+ E+ + +Y+ ME G ++ S L ++ + + Y K + A++ +H+HGIVH
Sbjct: 1356 FGVELHREEMYIFMEYCDEGTLEEVSRLGLQEHVI----RLYSKQITIAINVLHEHGIVH 1411
Query: 646 SDLKPAN-FLIVDGMLKLIDFGIANQMQPDTTSVVKD--SQVGTVNYMPPEAIKDMSSSR 702
D+K AN FL G++KL DFG + +++ + ++ + S +GT YM PE I +R
Sbjct: 1412 RDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-----TR 1466
Query: 703 ENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEK 762
G+ + +D+WSLGC++ M GK P+ + + ++ + H+ P+
Sbjct: 1467 AKGEGHGR---AADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYK-VGMGHKPPIPERLSP 1522
Query: 763 DLQDVLKCCLKRDPKQRISIPELLAHPYVQIQT 795
+ +D L CL+ DPK R + +LL H +V++ T
Sbjct: 1523 EGKDFLSHCLESDPKMRWTASQLLDHSFVKVCT 1555
>gi|162951881 tousled-like kinase 2 isoform B [Homo sapiens]
Length = 718
Score = 108 bits (269), Expect = 3e-23
Identities = 85/292 (29%), Positives = 145/292 (49%), Gaps = 37/292 (12%)
Query: 525 YSILKQIGSGGSSKVFQVLNEKKQIY-AIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582
Y +L +G GG S+V++ + +Q Y A+K L + ++ ++Y ++ +
Sbjct: 408 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL 467
Query: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638
D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ +
Sbjct: 468 DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 527
Query: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSVVKDSQV-----GTV 687
++ I+H DLKP N L+V+G +K+ DFG++ M D+ + V ++ GT
Sbjct: 528 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY 587
Query: 688 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQI 741
Y+PPE GK KIS K DVWS+G I Y YG+ PF Q I+ +
Sbjct: 588 WYLPPECFVV-------GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN 640
Query: 742 SKLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
+ L A E++FP P + + ++ CL + RI + +L PY+
Sbjct: 641 TILKAT-----EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 687
>gi|45643117 tousled-like kinase 2 isoform A [Homo sapiens]
Length = 750
Score = 108 bits (269), Expect = 3e-23
Identities = 85/292 (29%), Positives = 145/292 (49%), Gaps = 37/292 (12%)
Query: 525 YSILKQIGSGGSSKVFQVLNEKKQIY-AIKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582
Y +L +G GG S+V++ + +Q Y A+K L + ++ ++Y ++ +
Sbjct: 440 YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL 499
Query: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638
D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ +
Sbjct: 500 DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL 559
Query: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSVVKDSQV-----GTV 687
++ I+H DLKP N L+V+G +K+ DFG++ M D+ + V ++ GT
Sbjct: 560 NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY 619
Query: 688 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQI 741
Y+PPE GK KIS K DVWS+G I Y YG+ PF Q I+ +
Sbjct: 620 WYLPPECFVV-------GKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQEN 672
Query: 742 SKLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
+ L A E++FP P + + ++ CL + RI + +L PY+
Sbjct: 673 TILKAT-----EVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 719
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 107 bits (267), Expect = 5e-23
Identities = 78/277 (28%), Positives = 140/277 (50%), Gaps = 29/277 (10%)
Query: 524 IYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLN----KLQ 579
+Y + K +G G F V+ + ++ + V ++ D LD+ + KL
Sbjct: 15 LYDLDKTLGRGH----FAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLV 70
Query: 580 QHSDKIIRLYDYEITDQYIYMVMECGNI-DLNSWLKK-KKSIDPWERKSYWKNMLEAVHT 637
QH + I+RLY+ T +Y+++E G+ D+ ++ K ++ ++ K Y+ ++ A+
Sbjct: 71 QHPN-IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129
Query: 638 IHQHGIVHSDLKPANFLIVD--GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 695
H+ +VH DLKP N + + G++KL DFG +N+ QP + G++ Y PE +
Sbjct: 130 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLT---TSCGSLAYSAPEIL 186
Query: 696 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIE 755
+P D+WSLG IL+ + G+ PFQ+ N L I+D + +
Sbjct: 187 LGDEYD----------APAVDIWSLGVILFMLVCGQPPFQEA-NDSETLTMIMDCKYTV- 234
Query: 756 FPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 792
P K+ +D++ L+RDPK+R S+ E+ HP++Q
Sbjct: 235 -PSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQ 270
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 107 bits (267), Expect = 5e-23
Identities = 78/277 (28%), Positives = 140/277 (50%), Gaps = 29/277 (10%)
Query: 524 IYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLN----KLQ 579
+Y + K +G G F V+ + ++ + V ++ D LD+ + KL
Sbjct: 15 LYDLDKTLGRGH----FAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLV 70
Query: 580 QHSDKIIRLYDYEITDQYIYMVMECGNI-DLNSWLKK-KKSIDPWERKSYWKNMLEAVHT 637
QH + I+RLY+ T +Y+++E G+ D+ ++ K ++ ++ K Y+ ++ A+
Sbjct: 71 QHPN-IVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 129
Query: 638 IHQHGIVHSDLKPANFLIVD--GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 695
H+ +VH DLKP N + + G++KL DFG +N+ QP + G++ Y PE +
Sbjct: 130 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLT---TSCGSLAYSAPEIL 186
Query: 696 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIE 755
+P D+WSLG IL+ + G+ PFQ+ N L I+D + +
Sbjct: 187 LGDEYD----------APAVDIWSLGVILFMLVCGQPPFQEA-NDSETLTMIMDCKYTV- 234
Query: 756 FPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 792
P K+ +D++ L+RDPK+R S+ E+ HP++Q
Sbjct: 235 -PSHVSKECKDLITRMLQRDPKRRASLEEIENHPWLQ 270
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 107 bits (267), Expect = 5e-23
Identities = 76/274 (27%), Positives = 136/274 (49%), Gaps = 30/274 (10%)
Query: 525 YSILKQIGSGGSSKVFQVLNE-KKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 583
Y +L+ IG G +V++ + Q+ A+K++ + L + + EI + L+ +
Sbjct: 4 YHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPN- 62
Query: 584 KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGI 643
I+ + D TD+ + +V + +L L+ + + ++ ++ A++ +H H I
Sbjct: 63 -IVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRI 121
Query: 644 VHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSR 702
+H D+KP N L+ G +KL DFG A M T ++V S GT YM PE +++
Sbjct: 122 LHRDMKPQNILLAKGGGIKLCDFGFARAM--STNTMVLTSIKGTPLYMSPELVEERPYDH 179
Query: 703 ENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ-----QIINQISKLHAIIDPNHEIEFP 757
+D+WS+GCILY + G PF Q+++ I K DP + +P
Sbjct: 180 -----------TADLWSVGCILYELAVGTPPFYATSIFQLVSLILK-----DP---VRWP 220
Query: 758 DIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
++ L+ L +DP+QR+S P+LL HP++
Sbjct: 221 STISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI 254
>gi|211971038 tousled-like kinase 1 isoform 3 [Homo sapiens]
Length = 670
Score = 106 bits (265), Expect = 8e-23
Identities = 84/291 (28%), Positives = 143/291 (49%), Gaps = 36/291 (12%)
Query: 525 YSILKQIGSGGSSKVFQVLNEKKQIYA-IKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582
Y +L +G GG S+V++ + +Q YA +K L ++ ++ ++Y ++ +
Sbjct: 360 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 419
Query: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638
D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ +
Sbjct: 420 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 479
Query: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSV----VKDSQVGTVN 688
++ I+H DLKP N L+VDG +K+ DFG++ M D+ V + GT
Sbjct: 480 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 539
Query: 689 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQIS 742
Y+PPE GK KIS K DVWS+G I + YG+ PF Q I+ + +
Sbjct: 540 YLPPECFVV-------GKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENT 592
Query: 743 KLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
L A E++FP P + + ++ CL + R + +L PY+
Sbjct: 593 ILKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 638
>gi|211971036 tousled-like kinase 1 isoform 2 [Homo sapiens]
Length = 718
Score = 106 bits (265), Expect = 8e-23
Identities = 84/291 (28%), Positives = 143/291 (49%), Gaps = 36/291 (12%)
Query: 525 YSILKQIGSGGSSKVFQVLNEKKQIYA-IKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582
Y +L +G GG S+V++ + +Q YA +K L ++ ++ ++Y ++ +
Sbjct: 408 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 467
Query: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638
D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ +
Sbjct: 468 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 527
Query: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSV----VKDSQVGTVN 688
++ I+H DLKP N L+VDG +K+ DFG++ M D+ V + GT
Sbjct: 528 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 587
Query: 689 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQIS 742
Y+PPE GK KIS K DVWS+G I + YG+ PF Q I+ + +
Sbjct: 588 YLPPECFVV-------GKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENT 640
Query: 743 KLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
L A E++FP P + + ++ CL + R + +L PY+
Sbjct: 641 ILKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 686
>gi|33636698 tousled-like kinase 1 isoform 1 [Homo sapiens]
Length = 766
Score = 106 bits (265), Expect = 8e-23
Identities = 84/291 (28%), Positives = 143/291 (49%), Gaps = 36/291 (12%)
Query: 525 YSILKQIGSGGSSKVFQVLNEKKQIYA-IKYVNLEEA-DNQTLDSYRNEIAYLNKLQQHS 582
Y +L +G GG S+V++ + +Q YA +K L ++ ++ ++Y ++ +
Sbjct: 456 YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL 515
Query: 583 D--KIIRLYDYEI--TDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTI 638
D +I++LYDY TD + ++ C DL+ +LK+ K + E +S ++ A+ +
Sbjct: 516 DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL 575
Query: 639 HQ--HGIVHSDLKPANFLIVDGM----LKLIDFGIANQMQPDTTSV----VKDSQVGTVN 688
++ I+H DLKP N L+VDG +K+ DFG++ M D+ V + GT
Sbjct: 576 NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYW 635
Query: 689 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF------QQIINQIS 742
Y+PPE GK KIS K DVWS+G I + YG+ PF Q I+ + +
Sbjct: 636 YLPPECFVV-------GKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENT 688
Query: 743 KLHAIIDPNHEIEFPDIP--EKDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
L A E++FP P + + ++ CL + R + +L PY+
Sbjct: 689 ILKAT-----EVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL 734
>gi|27437025 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 3 [Homo sapiens]
Length = 545
Score = 105 bits (262), Expect = 2e-22
Identities = 91/379 (24%), Positives = 174/379 (45%), Gaps = 53/379 (13%)
Query: 482 STPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQ 541
S PY P Q ++ P ++ + +C+ + Y++ +IG G V
Sbjct: 125 SLPYS-PVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQ--YTLKDEIGKGSYGVVKL 181
Query: 542 VLNEKKQIY-AIKYVNLEEADNQT------------------------LDSYRNEIAYLN 576
NE Y A+K ++ ++ Q ++ EIA L
Sbjct: 182 AYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILK 241
Query: 577 KLQQHSD-KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 635
KL + K++ + D + + ++YMV E N + K + + + Y++++++ +
Sbjct: 242 KLDHPNVVKLVEVLD-DPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 636 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 694
+H I+H D+KP+N L+ DG +K+ DFG++N+ + + + + VGT +M PE+
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK--GSDALLSNTVGTPAFMAPES 358
Query: 695 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI 754
+S +R+ K+ DVW++G LY +G+ PF +I LH+ I + +
Sbjct: 359 ---LSETRKIFSGKA-----LDVWAMGVTLYCFVFGQCPFMD--ERIMCLHSKI-KSQAL 407
Query: 755 EFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYV 812
EFPD P+ +DL+D++ L ++P+ RI +PE+ I+ +G+ E +
Sbjct: 408 EFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREER-- 465
Query: 813 LGQLVGLNSPNSILKAAKT 831
L++P ++L T
Sbjct: 466 -----SLSAPGNLLTKKPT 479
>gi|27437023 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 6 [Homo sapiens]
Length = 490
Score = 105 bits (262), Expect = 2e-22
Identities = 91/379 (24%), Positives = 174/379 (45%), Gaps = 53/379 (13%)
Query: 482 STPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQ 541
S PY P Q ++ P ++ + +C+ + Y++ +IG G V
Sbjct: 125 SLPYS-PVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQ--YTLKDEIGKGSYGVVKL 181
Query: 542 VLNEKKQIY-AIKYVNLEEADNQT------------------------LDSYRNEIAYLN 576
NE Y A+K ++ ++ Q ++ EIA L
Sbjct: 182 AYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILK 241
Query: 577 KLQQHSD-KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 635
KL + K++ + D + + ++YMV E N + K + + + Y++++++ +
Sbjct: 242 KLDHPNVVKLVEVLD-DPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 636 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 694
+H I+H D+KP+N L+ DG +K+ DFG++N+ + + + + VGT +M PE+
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK--GSDALLSNTVGTPAFMAPES 358
Query: 695 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI 754
+S +R+ K+ DVW++G LY +G+ PF +I LH+ I + +
Sbjct: 359 ---LSETRKIFSGKA-----LDVWAMGVTLYCFVFGQCPFMD--ERIMCLHSKI-KSQAL 407
Query: 755 EFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYV 812
EFPD P+ +DL+D++ L ++P+ RI +PE+ I+ +G+ E +
Sbjct: 408 EFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREER-- 465
Query: 813 LGQLVGLNSPNSILKAAKT 831
L++P ++L T
Sbjct: 466 -----SLSAPGNLLTKKPT 479
>gi|27437019 calcium/calmodulin-dependent protein kinase kinase 2
beta isoform 4 [Homo sapiens]
Length = 498
Score = 105 bits (261), Expect = 2e-22
Identities = 90/374 (24%), Positives = 173/374 (46%), Gaps = 53/374 (14%)
Query: 482 STPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQ 541
S PY P Q ++ P ++ + +C+ + Y++ +IG G V
Sbjct: 125 SLPYS-PVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQ--YTLKDEIGKGSYGVVKL 181
Query: 542 VLNEKKQIY-AIKYVNLEEADNQT------------------------LDSYRNEIAYLN 576
NE Y A+K ++ ++ Q ++ EIA L
Sbjct: 182 AYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILK 241
Query: 577 KLQQHSD-KIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAV 635
KL + K++ + D + + ++YMV E N + K + + + Y++++++ +
Sbjct: 242 KLDHPNVVKLVEVLD-DPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI 300
Query: 636 HTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 694
+H I+H D+KP+N L+ DG +K+ DFG++N+ + + + + VGT +M PE+
Sbjct: 301 EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFK--GSDALLSNTVGTPAFMAPES 358
Query: 695 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI 754
+S +R+ K+ DVW++G LY +G+ PF +I LH+ I + +
Sbjct: 359 ---LSETRKIFSGKA-----LDVWAMGVTLYCFVFGQCPFMD--ERIMCLHSKI-KSQAL 407
Query: 755 EFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYV 812
EFPD P+ +DL+D++ L ++P+ RI +PE+ I+ +G+ E +
Sbjct: 408 EFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKILVKTMIRKRSFGNPFEGSRREER-- 465
Query: 813 LGQLVGLNSPNSIL 826
L++P ++L
Sbjct: 466 -----SLSAPGNLL 474
>gi|14150045 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
Length = 505
Score = 104 bits (260), Expect = 3e-22
Identities = 90/312 (28%), Positives = 148/312 (47%), Gaps = 45/312 (14%)
Query: 509 LASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQ---- 563
+A S A +C+ + Y + +IG G V NE + + YA+K ++ ++ Q
Sbjct: 114 VAISDAEDCVQLNQ--YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFP 171
Query: 564 --------------------TLDSYRNEIAYLNKLQQ-HSDKIIRLYDYEITDQYIYMVM 602
L+ EIA L KL + K+I + D D +Y+V
Sbjct: 172 RRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDN-LYLVF 230
Query: 603 ECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVD-GMLK 661
+ + K + + Y ++++ + +H IVH D+KP+N L+ D G +K
Sbjct: 231 DLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVK 290
Query: 662 LIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLG 721
+ DFG++NQ + + + S GT +M PEAI D S +GK+ DVW+ G
Sbjct: 291 IADFGVSNQFEGNDAQL--SSTAGTPAFMAPEAISDSGQSF-SGKAL-------DVWATG 340
Query: 722 CILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPE--KDLQDVLKCCLKRDPKQR 779
LY YGK PF I + I LH I N + FP+ PE ++L+D++ L ++P+ R
Sbjct: 341 VTLYCFVYGKCPF--IDDFILALHRKIK-NEPVVFPEEPEISEELKDLILKMLDKNPETR 397
Query: 780 ISIPELLAHPYV 791
I +P++ HP+V
Sbjct: 398 IGVPDIKLHPWV 409
>gi|27437011 calcium/calmodulin-dependent protein kinase 1 alpha
isoform a [Homo sapiens]
Length = 505
Score = 104 bits (260), Expect = 3e-22
Identities = 90/312 (28%), Positives = 148/312 (47%), Gaps = 45/312 (14%)
Query: 509 LASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQ---- 563
+A S A +C+ + Y + +IG G V NE + + YA+K ++ ++ Q
Sbjct: 114 VAISDAEDCVQLNQ--YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFP 171
Query: 564 --------------------TLDSYRNEIAYLNKLQQ-HSDKIIRLYDYEITDQYIYMVM 602
L+ EIA L KL + K+I + D D +Y+V
Sbjct: 172 RRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDN-LYLVF 230
Query: 603 ECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVD-GMLK 661
+ + K + + Y ++++ + +H IVH D+KP+N L+ D G +K
Sbjct: 231 DLLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVK 290
Query: 662 LIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLG 721
+ DFG++NQ + + + S GT +M PEAI D S +GK+ DVW+ G
Sbjct: 291 IADFGVSNQFEGNDAQL--SSTAGTPAFMAPEAISDSGQSF-SGKAL-------DVWATG 340
Query: 722 CILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPE--KDLQDVLKCCLKRDPKQR 779
LY YGK PF I + I LH I N + FP+ PE ++L+D++ L ++P+ R
Sbjct: 341 VTLYCFVYGKCPF--IDDFILALHRKIK-NEPVVFPEEPEISEELKDLILKMLDKNPETR 397
Query: 780 ISIPELLAHPYV 791
I +P++ HP+V
Sbjct: 398 IGVPDIKLHPWV 409
>gi|121114283 polo-like kinase 4 [Homo sapiens]
Length = 970
Score = 103 bits (258), Expect = 5e-22
Identities = 88/349 (25%), Positives = 160/349 (45%), Gaps = 52/349 (14%)
Query: 517 CISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTL------DSYRN 570
CI K + + +G G + V++ + I+ V ++ D + + +N
Sbjct: 4 CIGEKIEDFKVGNLLGKGSFAGVYRA----ESIHTGLEVAIKMIDKKAMYKAGMVQRVQN 59
Query: 571 EIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNSWLKKK-KSIDPWERKSYW 628
E+ +L+ S I+ LY+Y Y+Y+V+E C N ++N +LK + K E + +
Sbjct: 60 EVKIHCQLKHPS--ILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFM 117
Query: 629 KNMLEAVHTIHQHGIVHSDLKPANFLIVDGM-LKLIDFGIANQMQPDTTSVVKDSQVGTV 687
++ + +H HGI+H DL +N L+ M +K+ DFG+A Q++ + GT
Sbjct: 118 HQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHY--TLCGTP 175
Query: 688 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF--QQIINQISKLH 745
NY+ PE ++S +SDVWSLGC+ Y + G+ PF + N ++K+
Sbjct: 176 NYISPEIA-----------TRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVV 224
Query: 746 AIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGT 805
+ E P + +D++ L+R+P R+S+ +L HP++ + GT
Sbjct: 225 LA-----DYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS-RNSSTKSKDLGT 278
Query: 806 TEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKR 854
E+ ++S ++ + A T S S S F+K+R
Sbjct: 279 VED---------SIDSGHATISTAIT-------ASSSTSISGSLFDKRR 311
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 101 bits (252), Expect = 3e-21
Identities = 77/291 (26%), Positives = 143/291 (49%), Gaps = 24/291 (8%)
Query: 524 IYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 582
++ +L+++G G VF+ ++ E Q+ AIK V +E L EI+ + Q S
Sbjct: 26 VFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVES----DLQEIIKEISIMQ--QCDS 79
Query: 583 DKIIRLYDYEITDQYIYMVME-CGNIDLNSWLK-KKKSIDPWERKSYWKNMLEAVHTIHQ 640
+++ Y + +++VME CG ++ ++ + K++ E + K+ L+ + +H
Sbjct: 80 PYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHF 139
Query: 641 HGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMS 699
+H D+K N L+ +G KL DFG+A Q+ T +++ +GT +M PE I+++
Sbjct: 140 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTD--TMAKRNTVIGTPFWMAPEVIQEIG 197
Query: 700 SSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDI 759
+ +D+WSLG M GK P+ I + +P P++
Sbjct: 198 -----------YNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPEL 246
Query: 760 PEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMK 810
D D +K CL ++P+QR + +LL HP+++ PV+ + TE M+
Sbjct: 247 WSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK-NAKPVSILRDLITEAME 296
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 101 bits (251), Expect = 3e-21
Identities = 72/270 (26%), Positives = 139/270 (51%), Gaps = 20/270 (7%)
Query: 524 IYSILKQIGSGGSSKVFQVLNEKKQ-IYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 582
+++ L++IG G +VF+ ++ + Q + AIK ++LEEA+++ ++ + EI L+ Q S
Sbjct: 23 LFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDE-IEDIQQEITVLS--QCDS 79
Query: 583 DKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHG 642
+ + Y + D ++++ME L + +D + + + +L+ + +H
Sbjct: 80 PYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEK 139
Query: 643 IVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSS 701
+H D+K AN L+ + G +KL DFG+A Q+ T + +++ VGT +M PE IK
Sbjct: 140 KIHRDIKAANVLLSEHGEVKLADFGVAGQLTD--TQIKRNTFVGTPFWMAPEVIK----- 192
Query: 702 RENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPE 761
+S K+D+WSLG + G+ P ++ K+ +I N+
Sbjct: 193 ------QSAYDSKADIWSLGITAIELARGEPPHSEL--HPMKVLFLIPKNNPPTLEGNYS 244
Query: 762 KDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
K L++ ++ CL ++P R + ELL H ++
Sbjct: 245 KPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 101 bits (251), Expect = 3e-21
Identities = 72/270 (26%), Positives = 139/270 (51%), Gaps = 20/270 (7%)
Query: 524 IYSILKQIGSGGSSKVFQVLNEKKQ-IYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 582
+++ L++IG G +VF+ ++ + Q + AIK ++LEEA+++ ++ + EI L+ Q S
Sbjct: 35 LFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDE-IEDIQQEITVLS--QCDS 91
Query: 583 DKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHG 642
+ + Y + D ++++ME L + +D + + + +L+ + +H
Sbjct: 92 PYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEK 151
Query: 643 IVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSS 701
+H D+K AN L+ + G +KL DFG+A Q+ T + +++ VGT +M PE IK
Sbjct: 152 KIHRDIKAANVLLSEHGEVKLADFGVAGQLTD--TQIKRNTFVGTPFWMAPEVIK----- 204
Query: 702 RENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPE 761
+S K+D+WSLG + G+ P ++ K+ +I N+
Sbjct: 205 ------QSAYDSKADIWSLGITAIELARGEPPHSEL--HPMKVLFLIPKNNPPTLEGNYS 256
Query: 762 KDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
K L++ ++ CL ++P R + ELL H ++
Sbjct: 257 KPLKEFVEACLNKEPSFRPTAKELLKHKFI 286
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 99.8 bits (247), Expect = 1e-20
Identities = 114/491 (23%), Positives = 213/491 (43%), Gaps = 43/491 (8%)
Query: 312 PGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEET 371
P + S ++ +L Q K P E+ + L+ T +IT K + + + A L+
Sbjct: 101 PVTVASSQSEGKMPDLYGSQMCPGKLPEGIPEQWARLLQTSNIT-KLEQKKNPQAVLDVL 159
Query: 372 KEYQEPEVPESNQKQWQ----SKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQ 427
K Y E +NQK K I +P+++ + P LA V+ E+ E+
Sbjct: 160 KFYDSKETV-NNQKYMSFTSGDKSAHGYIAAHPSSTKTASE-PPLAPPVSEEEDEEEEEE 217
Query: 428 PVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKND--FPPACQLSTPY 485
+ PP+ + KSI + +P V N PP+ + +
Sbjct: 218 ---EDENEPPPVIAPRPEHTKSIYTR-------SVVESIASPAVPNKEVTPPSAENAN-- 265
Query: 486 GQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN- 544
++ Q + + + ++L + + + Y+ ++IG G S V+ L+
Sbjct: 266 -SSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDI 324
Query: 545 EKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMEC 604
Q AIK +NL++ + L NEI + + + I+ D + +++VME
Sbjct: 325 ATGQEVAIKQMNLQQQPKKEL--IINEILVMR--ENKNPNIVNYLDSYLVGDELWVVMEY 380
Query: 605 GNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLI 663
+ + + +D + + + L+A+ +H + ++H D+K N L+ +DG +KL
Sbjct: 381 LAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLT 440
Query: 664 DFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCI 723
DFG Q+ P+ + + + VGT +M PE + ++ PK D+WSLG +
Sbjct: 441 DFGFCAQITPEQSK--RSTMVGTPYWMAPEVV-----------TRKAYGPKVDIWSLGIM 487
Query: 724 LYYMTYGKTPFQQIINQISKLHAII-DPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISI 782
M G+ P+ N + L+ I + E++ P+ +D L CL+ D +R S
Sbjct: 488 AIEMVEGEPPYLNE-NPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSA 546
Query: 783 PELLAHPYVQI 793
ELL HP++++
Sbjct: 547 KELLQHPFLKL 557
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 99.8 bits (247), Expect = 1e-20
Identities = 83/272 (30%), Positives = 134/272 (49%), Gaps = 34/272 (12%)
Query: 525 YSILKQIGSGGSSKVFQV--LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 582
+ I K+IG G S+V++ L ++K + K E D + EI L +L +
Sbjct: 79 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPN 138
Query: 583 DKIIRLYDYEITDQYIYMVMECGNI-DLNS---WLKKKKSIDPWERKSYWKNMLE---AV 635
II+ D I D + +V+E + DL+ + KK+K + P ++ WK ++ AV
Sbjct: 139 --IIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIP--ERTVWKYFVQLCSAV 194
Query: 636 HTIHQHGIVHSDLKPAN-FLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 694
+H ++H D+KPAN F+ G++KL D G+ +TT+ S VGT YM PE
Sbjct: 195 EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAA--HSLVGTPYYMSPER 252
Query: 695 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI 754
I ENG + KSD+WSLGC+LY M ++PF L ++ +
Sbjct: 253 I------HENGYNF-----KSDIWSLGCLLYEMAALQSPF---YGDKMNLFSLCQKIEQC 298
Query: 755 EFPDIP----EKDLQDVLKCCLKRDPKQRISI 782
++P +P + L++++ C+ DP QR I
Sbjct: 299 DYPPLPGEHYSEKLRELVSMCICPDPHQRPDI 330
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 99.8 bits (247), Expect = 1e-20
Identities = 83/272 (30%), Positives = 134/272 (49%), Gaps = 34/272 (12%)
Query: 525 YSILKQIGSGGSSKVFQV--LNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHS 582
+ I K+IG G S+V++ L ++K + K E D + EI L +L +
Sbjct: 45 FQIEKKIGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPN 104
Query: 583 DKIIRLYDYEITDQYIYMVMECGNI-DLNS---WLKKKKSIDPWERKSYWKNMLE---AV 635
II+ D I D + +V+E + DL+ + KK+K + P ++ WK ++ AV
Sbjct: 105 --IIKYLDSFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIP--ERTVWKYFVQLCSAV 160
Query: 636 HTIHQHGIVHSDLKPAN-FLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEA 694
+H ++H D+KPAN F+ G++KL D G+ +TT+ S VGT YM PE
Sbjct: 161 EHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSETTAA--HSLVGTPYYMSPER 218
Query: 695 IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEI 754
I ENG + KSD+WSLGC+LY M ++PF L ++ +
Sbjct: 219 I------HENGYNF-----KSDIWSLGCLLYEMAALQSPF---YGDKMNLFSLCQKIEQC 264
Query: 755 EFPDIP----EKDLQDVLKCCLKRDPKQRISI 782
++P +P + L++++ C+ DP QR I
Sbjct: 265 DYPPLPGEHYSEKLRELVSMCICPDPHQRPDI 296
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 99.4 bits (246), Expect = 1e-20
Identities = 110/474 (23%), Positives = 209/474 (44%), Gaps = 43/474 (9%)
Query: 329 SVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQ 388
+V +S + + E+ + L+ T +IT K + + + A L+ K Y E +NQK
Sbjct: 103 TVASSQSEGKMGIPEQWARLLQTSNIT-KLEQKKNPQAVLDVLKFYDSKETV-NNQKYMS 160
Query: 389 ----SKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKW 444
K I +P+++ + P LA V+ E+ E+ + PP+ +
Sbjct: 161 FTSGDKSAHGYIAAHPSSTKTASE-PPLAPPVSEEEDEEEEEE---EDENEPPPVIAPRP 216
Query: 445 FDPKSICKTPSSNTLDDYMSCFRTPVVKND--FPPACQLSTPYGQPACFQQQQHQILATP 502
KSI + +P V N PP+ + + ++ Q +
Sbjct: 217 EHTKSIYTR-------SVVESIASPAVPNKEVTPPSAENAN---SSTLYRNTDRQRKKSK 266
Query: 503 LQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEAD 561
+ + ++L + + + Y+ ++IG G S V+ L+ Q AIK +NL++
Sbjct: 267 MTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQP 326
Query: 562 NQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDP 621
+ L NEI + + + I+ D + +++VME + + + +D
Sbjct: 327 KKEL--IINEILVMR--ENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDE 382
Query: 622 WERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI-VDGMLKLIDFGIANQMQPDTTSVVK 680
+ + + L+A+ +H + ++H D+K N L+ +DG +KL DFG Q+ P+ + +
Sbjct: 383 GQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSK--R 440
Query: 681 DSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQ 740
+ VGT +M PE + ++ PK D+WSLG + M G+ P+ N
Sbjct: 441 STMVGTPYWMAPEVV-----------TRKAYGPKVDIWSLGIMAIEMVEGEPPYLNE-NP 488
Query: 741 ISKLHAII-DPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQI 793
+ L+ I + E++ P+ +D L CL+ D +R S ELL HP++++
Sbjct: 489 LRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKL 542
>gi|148806859 calcium/calmodulin-dependent protein kinase 1 alpha
isoform b [Homo sapiens]
Length = 520
Score = 99.4 bits (246), Expect = 1e-20
Identities = 96/349 (27%), Positives = 156/349 (44%), Gaps = 81/349 (23%)
Query: 509 LASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKK-QIYAIKYVNLEEADNQ---- 563
+A S A +C+ + Y + +IG G V NE + + YA+K ++ ++ Q
Sbjct: 114 VAISDAEDCVQLNQ--YKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFP 171
Query: 564 --------------------TLDSYRNEIAYLNKLQQ-HSDKIIRLYDYEITDQ-YIYMV 601
L+ EIA L KL + K+I + D D Y+ +
Sbjct: 172 RRPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLALQ 231
Query: 602 MECGNIDLNSW-LKKKKSIDPWERKS---------------------------------- 626
+ NI L+S + K S+ P E++
Sbjct: 232 NQAQNIQLDSTNIAKPHSLLPSEQQDSGSTWAARSVFDLLRKGPVMEVPCDKPFSEEQAR 291
Query: 627 -YWKNMLEAVHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIANQMQPDTTSVVKDSQV 684
Y ++++ + +H IVH D+KP+N L+ D G +K+ DFG++NQ + + + S
Sbjct: 292 LYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGNDAQL--SSTA 349
Query: 685 GTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKL 744
GT +M PEAI D S +GK+ DVW+ G LY YGK PF I + I L
Sbjct: 350 GTPAFMAPEAISDSGQSF-SGKAL-------DVWATGVTLYCFVYGKCPF--IDDFILAL 399
Query: 745 HAIIDPNHEIEFPDIPE--KDLQDVLKCCLKRDPKQRISIPELLAHPYV 791
H I N + FP+ PE ++L+D++ L ++P+ RI +P++ HP+V
Sbjct: 400 HRKIK-NEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 447
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,379,319
Number of Sequences: 37866
Number of extensions: 1447460
Number of successful extensions: 5397
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 311
Number of HSP's successfully gapped in prelim test: 476
Number of HSP's that attempted gapping in prelim test: 3891
Number of HSP's gapped (non-prelim): 1004
length of query: 857
length of database: 18,247,518
effective HSP length: 111
effective length of query: 746
effective length of database: 14,044,392
effective search space: 10477116432
effective search space used: 10477116432
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.