Guide to the Human Genome
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Search of human proteins with 22907049

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
         (453 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]                 907   0.0  
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]                907   0.0  
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]                907   0.0  
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]        639   0.0  
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]       639   0.0  
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]      502   e-142
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]        502   e-142
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]       471   e-133
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]                 407   e-113
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]                 407   e-113
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]                161   1e-39
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]                159   4e-39
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]                 152   5e-37
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]       152   6e-37
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]       147   2e-35
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]       145   7e-35
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho...   144   1e-34
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa...   143   3e-34
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]       136   3e-32
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ...   136   4e-32
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo...   134   2e-31
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]       126   4e-29
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap...   125   1e-28
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]       125   1e-28
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]       103   4e-22
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa...    92   1e-18
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo...    79   1e-14
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]       79   1e-14
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo...    79   1e-14
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform...    46   6e-05

>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  907 bits (2345), Expect = 0.0
 Identities = 453/453 (100%), Positives = 453/453 (100%)

Query: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
Sbjct: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
           YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
Sbjct: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
           TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180

Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
           FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240

Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
           GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300

Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
           QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360

Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
           PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420

Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453
           TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453


>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  907 bits (2345), Expect = 0.0
 Identities = 453/453 (100%), Positives = 453/453 (100%)

Query: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
Sbjct: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
           YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
Sbjct: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
           TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180

Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
           FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240

Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
           GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300

Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
           QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360

Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
           PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420

Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453
           TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453


>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
          Length = 453

 Score =  907 bits (2345), Expect = 0.0
 Identities = 453/453 (100%), Positives = 453/453 (100%)

Query: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
Sbjct: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
           YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
Sbjct: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
           TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180

Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
           FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240

Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
           GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300

Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
           QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360

Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
           PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420

Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453
           TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453


>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
          Length = 485

 Score =  639 bits (1648), Expect = 0.0
 Identities = 297/439 (67%), Positives = 377/439 (85%)

Query: 8   VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67
           V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V
Sbjct: 5   VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64

Query: 68  LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127
           L EI++M++ LPEW   +PV+K   T  DE YI  +PLGVVL+IG WNYPF LTIQP++G
Sbjct: 65  LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124

Query: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187
           AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT
Sbjct: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184

Query: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247
           G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP
Sbjct: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244

Query: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307
           DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG
Sbjct: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304

Query: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367
             D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F
Sbjct: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364

Query: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427
           S N K+IK+MI ETSSGGV  NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R 
Sbjct: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424

Query: 428 CLVRPLMNDEGLKVRYPPS 446
           CL++ L  +   K+RYPP+
Sbjct: 425 CLLKSLKREGANKLRYPPN 443


>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
          Length = 508

 Score =  639 bits (1648), Expect = 0.0
 Identities = 297/439 (67%), Positives = 377/439 (85%)

Query: 8   VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67
           V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V
Sbjct: 5   VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64

Query: 68  LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127
           L EI++M++ LPEW   +PV+K   T  DE YI  +PLGVVL+IG WNYPF LTIQP++G
Sbjct: 65  LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124

Query: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187
           AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT
Sbjct: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184

Query: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247
           G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP
Sbjct: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244

Query: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307
           DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG
Sbjct: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304

Query: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367
             D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F
Sbjct: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364

Query: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427
           S N K+IK+MI ETSSGGV  NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R 
Sbjct: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424

Query: 428 CLVRPLMNDEGLKVRYPPS 446
           CL++ L  +   K+RYPP+
Sbjct: 425 CLLKSLKREGANKLRYPPN 443


>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
          Length = 468

 Score =  502 bits (1292), Expect = e-142
 Identities = 242/451 (53%), Positives = 324/451 (71%), Gaps = 1/451 (0%)

Query: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           M  + + ++R R AF +GRTRP +FR  QL+ L R +QE +Q L  ALA DLHK+ + + 
Sbjct: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
             EV     E+   ++ L  W  DE V K   TQ D  +I  EP G+VL+I  WNYP NL
Sbjct: 61  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
           T+ P+VGA+AAGN VVLKPSE+S+N+  +LA ++PQY+D+  + V+ GG  ET +LL+ R
Sbjct: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180

Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
           FD+I +TGS  VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD      R+AW ++ N+
Sbjct: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240

Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
           GQTCVAPDY+LC P +Q +++  L+ ++  FYG+D + S + GRII+ + FQR+  L+  
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300

Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
            +VA GG  D + RYIAPT+L DV    PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360

Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
           PLALY FS++ +V+K+++ +TSSGG   ND  +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420

Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
           TFSH R+CL+R    ++   +RYPP SP ++
Sbjct: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 451


>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
          Length = 468

 Score =  502 bits (1292), Expect = e-142
 Identities = 242/451 (53%), Positives = 324/451 (71%), Gaps = 1/451 (0%)

Query: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           M  + + ++R R AF +GRTRP +FR  QL+ L R +QE +Q L  ALA DLHK+ + + 
Sbjct: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
             EV     E+   ++ L  W  DE V K   TQ D  +I  EP G+VL+I  WNYP NL
Sbjct: 61  VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
           T+ P+VGA+AAGN VVLKPSE+S+N+  +LA ++PQY+D+  + V+ GG  ET +LL+ R
Sbjct: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180

Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
           FD+I +TGS  VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD      R+AW ++ N+
Sbjct: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240

Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
           GQTCVAPDY+LC P +Q +++  L+ ++  FYG+D + S + GRII+ + FQR+  L+  
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300

Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
            +VA GG  D + RYIAPT+L DV    PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360

Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
           PLALY FS++ +V+K+++ +TSSGG   ND  +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420

Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
           TFSH R+CL+R    ++   +RYPP SP ++
Sbjct: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 451


>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
          Length = 431

 Score =  471 bits (1211), Expect = e-133
 Identities = 233/451 (51%), Positives = 309/451 (68%), Gaps = 38/451 (8%)

Query: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           M  + + ++R R AF +GRTRP +FR  QL+ L R +QE +Q L  ALA DLHK      
Sbjct: 1   MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK------ 54

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
                                           TQ D  +I  EP G+VL+I  WNYP NL
Sbjct: 55  -------------------------------ATQLDSAFIRKEPFGLVLIIAPWNYPLNL 83

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
           T+ P+VGA+AAGN VVLKPSE+S+N+  +LA ++PQY+D+  + V+ GG  ET +LL+ R
Sbjct: 84  TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 143

Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
           FD+I +TGS  VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD      R+AW ++ N+
Sbjct: 144 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 203

Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
           GQTCVAPDY+LC P +Q +++  L+ ++  FYG+D + S + GRII+ + FQR+  L+  
Sbjct: 204 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 263

Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
            +VA GG  D + RYIAPT+L DV    PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 264 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323

Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
           PLALY FS++ +V+K+++ +TSSGG   ND  +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383

Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
           TFSH R+CL+R    ++   +RYPP SP ++
Sbjct: 384 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 414


>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
          Length = 385

 Score =  407 bits (1045), Expect = e-113
 Identities = 191/362 (52%), Positives = 263/362 (72%)

Query: 84  DEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELS 143
           DEP       + D ++I  EP G+VL+I  WNYP NLT+  +VGA+AAG+ VVLKPSE+S
Sbjct: 3   DEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEIS 62

Query: 144 ENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKH 203
           +    +LA ++PQYLD+  + V+ GG  ET +LL+ + D+I +TGS  VGKI+MTAA KH
Sbjct: 63  QGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKH 122

Query: 204 LTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK 263
           LTPVTLELGGK+PCYVD NCD      R+AW  + N+GQTCVAPDY+LC P +Q +++  
Sbjct: 123 LTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPA 182

Query: 264 LKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTD 323
           L+ ++  FYG+D + S + GRII+ + FQR+  L+   +VA GG  + + RYIAPT+L D
Sbjct: 183 LQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVD 242

Query: 324 VDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSS 383
           V    PVMQEEIFGP+LPIV V+S++EAI+FIN++EKPLALY FS++ +V+ +M+  TSS
Sbjct: 243 VQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSS 302

Query: 384 GGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRY 443
           G    N+   +I+L S+PFGGVG+SGMG YHGK +F+TFSH R+CL+ P   ++  ++ Y
Sbjct: 303 GSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEIHY 362

Query: 444 PP 445
           PP
Sbjct: 363 PP 364


>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
          Length = 385

 Score =  407 bits (1045), Expect = e-113
 Identities = 191/362 (52%), Positives = 263/362 (72%)

Query: 84  DEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELS 143
           DEP       + D ++I  EP G+VL+I  WNYP NLT+  +VGA+AAG+ VVLKPSE+S
Sbjct: 3   DEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEIS 62

Query: 144 ENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKH 203
           +    +LA ++PQYLD+  + V+ GG  ET +LL+ + D+I +TGS  VGKI+MTAA KH
Sbjct: 63  QGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKH 122

Query: 204 LTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK 263
           LTPVTLELGGK+PCYVD NCD      R+AW  + N+GQTCVAPDY+LC P +Q +++  
Sbjct: 123 LTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPA 182

Query: 264 LKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTD 323
           L+ ++  FYG+D + S + GRII+ + FQR+  L+   +VA GG  + + RYIAPT+L D
Sbjct: 183 LQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVD 242

Query: 324 VDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSS 383
           V    PVMQEEIFGP+LPIV V+S++EAI+FIN++EKPLALY FS++ +V+ +M+  TSS
Sbjct: 243 VQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSS 302

Query: 384 GGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRY 443
           G    N+   +I+L S+PFGGVG+SGMG YHGK +F+TFSH R+CL+ P   ++  ++ Y
Sbjct: 303 GSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEIHY 362

Query: 444 PP 445
           PP
Sbjct: 363 PP 364


>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
          Length = 518

 Score =  161 bits (407), Expect = 1e-39
 Identities = 126/444 (28%), Positives = 210/444 (47%), Gaps = 24/444 (5%)

Query: 3   KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
           +++ AV+ A+AAF     +    R + L    R+I+E+E E+      +  K+ + A  +
Sbjct: 74  EVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLD 133

Query: 63  EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122
                ++     ++     AA    E          Y   EPLGV + IG WNYPF +  
Sbjct: 134 -----IDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIAS 188

Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERF 181
                A+A GN++V KPS  +   A LLA I  +  +   L+ V+ GG   T + L +  
Sbjct: 189 WKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHP 247

Query: 182 D--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
           D   + +TGS   G  IM  +AK + PVTLELGGKSP  +  +CD++ A +      F+ 
Sbjct: 248 DVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLT 307

Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298
            GQ C     +     I ++  E++ K  +    G+   +    G +I+  H +RV+G +
Sbjct: 308 QGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV 367

Query: 299 -----EGQKVAYGG----TGDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346
                +G KV  GG      D   +   Y+ P +LT+       ++EEIFGPV+ I+   
Sbjct: 368 KVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFD 427

Query: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406
           +  E ++  N     LA  +F+ + +   +++AE  +G    N+   +++   LPFGG  
Sbjct: 428 TEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGGYK 485

Query: 407 NSGMGSYHGKKSFETFSHRRSCLV 430
            SG G  +G+ + E +S  ++  V
Sbjct: 486 KSGFGRENGRVTIEYYSQLKTVCV 509


>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
          Length = 512

 Score =  159 bits (403), Expect = 4e-39
 Identities = 120/442 (27%), Positives = 206/442 (46%), Gaps = 20/442 (4%)

Query: 4   ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           + +AV+ A+ AF  G   R      R + L  L  L++     L      D  K   +A+
Sbjct: 71  VDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAF 130

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
           + ++   +  + Y       WA     +  P       +   EP+GV   I  WN+P  +
Sbjct: 131 FIDLEGCIRTLRYFAG----WADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLM 186

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
            +  +  A+  GN++VLKP+E +   A  L ++I +      +  ++ G  P     +  
Sbjct: 187 LVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISS 246

Query: 180 --RFDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
             + + I +TGST VGK++  AA++ +L  VTLELGGK+PC V  + DLD+A      G 
Sbjct: 247 HPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGV 306

Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
           F N GQ C A   +  +  + ++ V + ++ + K   G+      + G  I  + F +++
Sbjct: 307 FFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKIL 366

Query: 296 GLI-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349
            LI     EG K+  GG+  +    +I PT+ ++V     + +EEIFGPV PI+  +S+E
Sbjct: 367 ELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIE 426

Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409
           E I+  N  +  L   +F+ N     K+ +   SG V  N    +      PFGG   SG
Sbjct: 427 EVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWIN--CYNALYAQAPFGGFKMSG 484

Query: 410 MGSYHGKKSFETFSHRRSCLVR 431
            G   G+ +   ++  ++  ++
Sbjct: 485 NGRELGEYALAEYTEVKTVTIK 506


>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
          Length = 501

 Score =  152 bits (385), Expect = 5e-37
 Identities = 133/447 (29%), Positives = 209/447 (46%), Gaps = 30/447 (6%)

Query: 4   ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           + +AVK AR AF  G   RT     R + L  L  LI+     L    + +  K   NAY
Sbjct: 60  VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY 119

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
             ++   ++ + Y       WA        P       Y   EP+GV   I  WN+P  +
Sbjct: 120 LNDLAGCIKTLRYCAG----WADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVM 175

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
            I  +  A++ GN+VV+KP+E +   A  +A++I +      +  ++ G  P     +  
Sbjct: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235

Query: 180 RFD--HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
             D   + +TGST VGK+I  AA K +L  VTLELGGKSPC V  + DLD A      G 
Sbjct: 236 HMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGV 295

Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
           F + GQ C+A   I  + SI ++ V + ++++ K   G         G  I    + +++
Sbjct: 296 FYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKIL 355

Query: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
            LI     EG K+  GG G    +  ++ PT+ ++V  +  + +EEIFGPV  I+  +SL
Sbjct: 356 DLIESGKKEGAKLECGG-GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSL 414

Query: 349 EEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAANDVIVH---ITLHSLPFGG 404
           ++ I+  N     L+  +F+ + DK I      T S  + A  V V+   +     PFGG
Sbjct: 415 DDVIKRANNTFYGLSAGVFTKDIDKAI------TISSALQAGTVWVNCYGVVSAQCPFGG 468

Query: 405 VGNSGMGSYHGKKSFETFSHRRSCLVR 431
              SG G   G+  F  ++  ++  V+
Sbjct: 469 FKMSGNGRELGEYGFHEYTEVKTVTVK 495


>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
          Length = 487

 Score =  152 bits (384), Expect = 6e-37
 Identities = 131/454 (28%), Positives = 214/454 (47%), Gaps = 38/454 (8%)

Query: 3   KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
           +I  AVK AR AF S  +R  Q R + L  +  L+++  +E   A + D  K    A   
Sbjct: 46  EIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALAR-- 103

Query: 63  EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL----YIHSEPLGVVLVIGTWNYPF 118
                  +I   +Q    +A+      +  TQ D L    Y    P+GV  +I  WN P 
Sbjct: 104 -----TMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPL 158

Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPET 173
            L    +  A+AAGN+V+ KPSEL+    S+ A ++ + LDK   P     ++ G  P  
Sbjct: 159 YLLTWKIAPAMAAGNTVIAKPSELT----SVTAWMLCKLLDKAGVPPGVVNIVFGTGPRV 214

Query: 174 TELLKERFDH--ILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231
            E L    +   I +TGS    + I   +A H   ++LELGGK+P  + ++ +LD     
Sbjct: 215 GEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPA 274

Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARH 290
                F N G+ C+    I    SI ++ +++  ++ +++  G  +      G +IS  H
Sbjct: 275 TVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAH 334

Query: 291 FQRVMG-----LIEGQKVAYGGTGDA--------ATRYIAPTILTDVDPQSPVMQEEIFG 337
            ++V       L EG ++  G   D         A  ++ PT++TD+  +S  M EEIFG
Sbjct: 335 LEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394

Query: 338 PVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITL 397
           PV  +V   S EE I+  N  +  LA  ++SSN   + ++  +  SG V  N  ++    
Sbjct: 395 PVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIREL- 453

Query: 398 HSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431
            +LPFGG+ +SG+G    K S++ F+  ++  V+
Sbjct: 454 -NLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486


>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
          Length = 517

 Score =  147 bits (371), Expect = 2e-35
 Identities = 123/440 (27%), Positives = 199/440 (45%), Gaps = 16/440 (3%)

Query: 4   ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63
           +  AVK AR AF  G         ++   L RL    E++ V   + +   N    + E 
Sbjct: 76  VDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNG-KPFQES 134

Query: 64  VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123
               L+E+  + +    WA     +  P   Q   +   EP+GV   I  WN+P  +   
Sbjct: 135 YALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGW 194

Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFD 182
            +  A+A GN+VV+K +E +   A  LA++I +      +  +I G  P     + +  D
Sbjct: 195 KLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVD 254

Query: 183 --HILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
              + +TGST VG +I  AA   +L  VTLELGGKSP  V  + D++ A  +     F N
Sbjct: 255 VDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFN 314

Query: 240 SGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298
            GQ C A      + SI N+ +E+ ++K+ +   G   +     G  +    F+RV+G I
Sbjct: 315 MGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYI 374

Query: 299 -----EGQKVAYGGT--GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
                EG K+  GG   G+    +I PT+   V     + +EEIFGPV P+   + +EE 
Sbjct: 375 QLGQKEGAKLLCGGERFGERGF-FIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEV 433

Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411
           ++  N     LA  +F+ +            +G V  N   + +T H+ PFGG   SG G
Sbjct: 434 VERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNI-VTCHT-PFGGFKESGNG 491

Query: 412 SYHGKKSFETFSHRRSCLVR 431
              G+   + ++  ++  ++
Sbjct: 492 RELGEDGLKAYTEVKTVTIK 511


>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
          Length = 518

 Score =  145 bits (366), Expect = 7e-35
 Identities = 122/443 (27%), Positives = 205/443 (46%), Gaps = 22/443 (4%)

Query: 4   ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           I +AV+ AR AFS G   R      R + L+ L  L++     L    + +  K    A+
Sbjct: 77  IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 136

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
           Y ++  V++   Y       WA        P       +   EP+GV   I  WN+P  +
Sbjct: 137 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 192

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
               +  A+  GN+VV+KP+E +   A  +  +I +      +  ++ G  P     +  
Sbjct: 193 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIAS 252

Query: 180 RF--DHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
               D I +TGST VGK+I  AA + +L  VTLELGGKSP  +  + DLD A  +   G 
Sbjct: 253 HIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGV 312

Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
           F N GQ C A   I  + SI  + V + ++++ +   G     + + G  I  + + +++
Sbjct: 313 FFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKIL 372

Query: 296 -----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349
                G+ EG K+  GG G      +I PT+ ++V     + +EEIFGPV  I+  ++++
Sbjct: 373 ELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMD 432

Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNS 408
           E I+  N  +  L   +F+++   I K +  +S+       +  +  L++  PFGG   S
Sbjct: 433 EVIERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMS 489

Query: 409 GMGSYHGKKSFETFSHRRSCLVR 431
           G G   G+     +S  ++  V+
Sbjct: 490 GNGREMGEFGLREYSEVKTVTVK 512


>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
           sapiens]
          Length = 517

 Score =  144 bits (364), Expect = 1e-34
 Identities = 125/443 (28%), Positives = 198/443 (44%), Gaps = 22/443 (4%)

Query: 4   ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           + +AVK ARAAF  G   R      R + L  L  LI+     L      D  K    +Y
Sbjct: 76  VDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISY 135

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
             ++  VL+ + Y       WA     +  P       Y   EP+GV   I  WN+P  +
Sbjct: 136 LVDLDMVLKCLRYYAG----WADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLM 191

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK- 178
               +  A+A GN VV+K +E +   A  +A +I +      +  ++ G  P     +  
Sbjct: 192 QAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIAS 251

Query: 179 -ERFDHILYTGSTGVGKIIMTAA-AKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
            E  D + +TGST +G++I  AA + +L  VTLELGGKSP  +  + D+D A  +  +  
Sbjct: 252 HEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFAL 311

Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
           F N GQ C A         I ++ VE+ + ++     G       + G  +    F++++
Sbjct: 312 FFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKIL 371

Query: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
           G I     EG K+  GG G AA R  +I PT+  DV     + +EEIFGPV+ I+  +++
Sbjct: 372 GYINTGKQEGAKLLCGG-GIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTI 430

Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408
           EE +   N     LA  +F+ +      +     +G V  N     +     PFGG   S
Sbjct: 431 EEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYKMS 488

Query: 409 GMGSYHGKKSFETFSHRRSCLVR 431
           G G   G+   + ++  ++  V+
Sbjct: 489 GSGRELGEYGLQAYTEVKTVTVK 511


>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
           sapiens]
          Length = 923

 Score =  143 bits (361), Expect = 3e-34
 Identities = 116/437 (26%), Positives = 205/437 (46%), Gaps = 17/437 (3%)

Query: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58
           ++ + +AV  A+ AF +G    +  R +   +  L  L++E ++EL    A D       
Sbjct: 479 LADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTL 538

Query: 59  AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118
           A    +   ++   Y      +           +  ++  +   EPLGV  +I  WNYP 
Sbjct: 539 ALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPL 598

Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177
            +        +AAGN++VLKP++++   A   A + +     K +  +I G      + L
Sbjct: 599 MMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRL 658

Query: 178 KERFD--HILYTGSTGVGKIIM-TAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234
            E  D   + +TGST +GK IM + A  +L  V+LELGGKSP  +  +C+LD A R    
Sbjct: 659 SEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMG 718

Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293
             F N G+ C+A   +  + SI ++ V ++ + +K+   G+   +S D+G      H ++
Sbjct: 719 AVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEK 778

Query: 294 VM-----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347
           ++     G+ EG  + YGG        ++ PT+ TDV+    + +EE FGP++ I   ++
Sbjct: 779 LLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQN 838

Query: 348 --LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405
             ++  +Q  N  E  LA  +F+ +      +  +  +G V  N    + T  + PFGGV
Sbjct: 839 GDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFIN--TYNKTDVAAPFGGV 896

Query: 406 GNSGMGSYHGKKSFETF 422
             SG G   G+++   +
Sbjct: 897 KQSGFGKDLGEEALNEY 913


>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
          Length = 422

 Score =  136 bits (343), Expect = 3e-32
 Identities = 111/414 (26%), Positives = 191/414 (46%), Gaps = 19/414 (4%)

Query: 30  LEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEK 89
           L+ L  L++     L    + +  K    A+Y ++  V++   Y       WA       
Sbjct: 10  LDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAG----WADKIHGMT 65

Query: 90  TPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASL 149
            P       +   EP+GV   I  WN+P  +    +  A+  GN+VV+KP+E +   A  
Sbjct: 66  IPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALY 125

Query: 150 LATIIPQY-LDKDLYPVINGGVPETTELLKERF--DHILYTGSTGVGKIIMTAAAK-HLT 205
           +  +I +      +  ++ G  P     +      D I +TGST VGK+I  AA + +L 
Sbjct: 126 MGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLK 185

Query: 206 PVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-L 264
            VTLELGGKSP  +  + DLD A  +   G F N GQ C A   I  + SI  + V + +
Sbjct: 186 RVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSV 245

Query: 265 KKSLKEFYGEDAKKSRDYGRIISARHFQRVM-----GLIEGQKVAYGGTG-DAATRYIAP 318
           +++ +   G     + + G  I  + + +++     G+ EG K+  GG G      +I P
Sbjct: 246 ERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEP 305

Query: 319 TILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMI 378
           T+ ++V     + +EEIFGPV  I+  ++++E I+  N  +  L   +F+++   I K +
Sbjct: 306 TVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTND---INKAL 362

Query: 379 AETSSGGVAANDVIVHITLHS-LPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431
             +S+       +  +  L++  PFGG   SG G   G+     +S  ++  V+
Sbjct: 363 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 416


>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
           sapiens]
          Length = 535

 Score =  136 bits (342), Expect = 4e-32
 Identities = 120/432 (27%), Positives = 197/432 (45%), Gaps = 24/432 (5%)

Query: 7   AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 66
           AV+ A  AF   R    + R   L     L+ + + +L   + A+  K    A+  E++Y
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159

Query: 67  VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126
               +E+  ++      D  +  TP   +  L +  +P+GV  VI  WN+P  +  + + 
Sbjct: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVL-KQPIGVAAVITPWNFPSAMITRKVG 216

Query: 127 GAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTEL-----LKER 180
            A+AAG +VV+KP+E +   A  LA +  Q  +   +Y VI        E+         
Sbjct: 217 AALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL 276

Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
              I +TGST  GKI++  AA  +  V++ELGG +P  V  + ++D A       KF N+
Sbjct: 277 VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNT 336

Query: 241 GQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVM- 295
           GQTCV  +  L    I +  V    E +KK+L+   G   ++    G +I+ +  ++V  
Sbjct: 337 GQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQGPLINEKAVEKVEK 394

Query: 296 ----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350
                + +G  V  GG        +  PT+L +V        EE FGP+ P++   + EE
Sbjct: 395 QVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEE 454

Query: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410
           AI   N  +  LA Y +S +   I ++  +   G V  N+ +  I+    PFGGV  SG+
Sbjct: 455 AIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGL 512

Query: 411 GSYHGKKSFETF 422
           G    K   + +
Sbjct: 513 GREGSKYGIDEY 524


>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
           sapiens]
          Length = 548

 Score =  134 bits (337), Expect = 2e-31
 Identities = 123/446 (27%), Positives = 203/446 (45%), Gaps = 39/446 (8%)

Query: 7   AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 66
           AV+ A  AF   R    + R   L     L+ + + +L   + A+  K    A+  E++Y
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159

Query: 67  VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126
               +E+  ++      D  +  TP   +  L +  +P+GV  VI  WN+P  +  + + 
Sbjct: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVL-KQPIGVAAVITPWNFPSAMITRKVG 216

Query: 127 GAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVI---NGGVPE--------TTE 175
            A+AAG +VV+KP+E +   A  LA +   +L  DL P++     G+P         + +
Sbjct: 217 AALAAGCTVVVKPAEDTPFSALALAEVNQGFL-LDLDPLLLASQAGIPSGVYNVIPCSRK 275

Query: 176 LLKE---------RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLD 226
             KE             I +TGST  GKI++  AA  +  V++ELGG +P  V  + ++D
Sbjct: 276 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVD 335

Query: 227 VACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDY 282
            A       KF N+GQTCV  +  L    I +  V    E +KK+L+   G   ++    
Sbjct: 336 QAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQ 393

Query: 283 GRIISARHFQRVM-----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIF 336
           G +I+ +  ++V       + +G  V  GG        +  PT+L +V        EE F
Sbjct: 394 GPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETF 453

Query: 337 GPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHIT 396
           GP+ P++   + EEAI   N  +  LA Y +S +   I ++  +   G V  N+ +  I+
Sbjct: 454 GPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--IS 511

Query: 397 LHSLPFGGVGNSGMGSYHGKKSFETF 422
               PFGGV  SG+G    K   + +
Sbjct: 512 SVECPFGGVKQSGLGREGSKYGIDEY 537


>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
          Length = 480

 Score =  126 bits (317), Expect = 4e-29
 Identities = 114/440 (25%), Positives = 192/440 (43%), Gaps = 54/440 (12%)

Query: 4   ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           I +AV+ AR AFS G   R      R + L+ L  L++     L    + +  K    A+
Sbjct: 77  IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 136

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
           Y ++  V++   Y       WA        P       +   EP+GV   I  WN+P  +
Sbjct: 137 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 192

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
               +  A+  GN+VV+KP+E +   A  +  +I +                        
Sbjct: 193 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------------------ 228

Query: 181 FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
                      VGK+I  AA + +L  VTLELGGKSP  +  + DLD A  +   G F N
Sbjct: 229 -----------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFN 277

Query: 240 SGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM--- 295
            GQ C A   I  + SI  + V + ++++ +   G     + + G  I  + + +++   
Sbjct: 278 QGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELI 337

Query: 296 --GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAI 352
             G+ EG K+  GG G      +I PT+ ++V     + +EEIFGPV  I+  ++++E I
Sbjct: 338 QSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVI 397

Query: 353 QFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNSGMG 411
           +  N  +  L   +F+++   I K +  +S+       +  +  L++  PFGG   SG G
Sbjct: 398 ERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNG 454

Query: 412 SYHGKKSFETFSHRRSCLVR 431
              G+     +S  ++  V+
Sbjct: 455 REMGEFGLREYSEVKTVTVK 474


>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
           sapiens]
          Length = 902

 Score =  125 bits (313), Expect = 1e-28
 Identities = 113/437 (25%), Positives = 196/437 (44%), Gaps = 17/437 (3%)

Query: 1   MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58
           ++ + +AV  A+ AF +GR   +  R +   +  L  L+++ ++EL    A D       
Sbjct: 458 VTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTL 517

Query: 59  AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118
           A    V   ++   Y      +           +  ++      EP+GV  +I  WNYP 
Sbjct: 518 ALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPL 577

Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177
            +        +AAGN+VV+KP++++   A   A + +   + K +  V+ G      + L
Sbjct: 578 MMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRL 637

Query: 178 KERFD--HILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234
            +  D   I +TGST VGK IM + A  ++  V+LELGGKSP  +  +CDL+ A +    
Sbjct: 638 SDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMS 697

Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293
             F N G+ C+A   +  + SI ++ V ++ + +++   G    +  D+G      H  +
Sbjct: 698 SVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVK 757

Query: 294 VM-----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPI--VCV 345
           +M     G+ EG  +  GG        +  PT+ TDV+    + +EE FGPV+ I     
Sbjct: 758 LMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFAD 817

Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405
             L+  +   N  E  LA  +F+ +      +  +  +G V  N    + T  + PFGG 
Sbjct: 818 GDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVN--TYNKTDVAAPFGGF 875

Query: 406 GNSGMGSYHGKKSFETF 422
             SG G   G+ +   +
Sbjct: 876 KQSGFGKDLGEAALNEY 892


>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
          Length = 433

 Score =  125 bits (313), Expect = 1e-28
 Identities = 120/440 (27%), Positives = 193/440 (43%), Gaps = 64/440 (14%)

Query: 3   KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
           +I  AVK AR AF S  +R  Q R + L  +  L+++  +E   A + D  K    A   
Sbjct: 46  EIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALAR-- 103

Query: 63  EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL----YIHSEPLGVVLVIGTWNYPF 118
                  +I   +Q    +A+      +  TQ D L    Y    P+GV  +I  WN P 
Sbjct: 104 -----TMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPL 158

Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPET 173
            L    +  A+AAGN+V+ KPSEL+    S+ A ++ + LDK   P     ++ G  P  
Sbjct: 159 YLLTWKIAPAMAAGNTVIAKPSELT----SVTAWMLCKLLDKAGVPPGVVNIVFGTGPRV 214

Query: 174 TELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231
            E L        I +TGS    + I   +A H   ++LELGGK+P  + ++ +LD     
Sbjct: 215 GEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPA 274

Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHF 291
                F N                +++ +   L +  + + GE   K             
Sbjct: 275 TVRSSFAN---------------QVRSYVKRALAEGAQIWCGEGVDK------------- 306

Query: 292 QRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
              + L    +  Y         ++ PT++TD+  +S  M EEIFGPV  +V   S EE 
Sbjct: 307 ---LSLPARNQAGY---------FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEV 354

Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411
           I+  N  +  LA  ++SSN   + ++  +  SG V  N  ++     +LPFGG+ +SG+G
Sbjct: 355 IERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIREL--NLPFGGMKSSGIG 412

Query: 412 SYHGKKSFETFSHRRSCLVR 431
               K S++ F+  ++  V+
Sbjct: 413 REGAKDSYDFFTEIKTITVK 432


>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
          Length = 535

 Score =  103 bits (256), Expect = 4e-22
 Identities = 103/441 (23%), Positives = 188/441 (42%), Gaps = 21/441 (4%)

Query: 2   SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61
           +++  A+   + AF +     +  R Q L   Q+LI+E  +E+   +  +  K   +A  
Sbjct: 77  AEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAE- 135

Query: 62  EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQD-ELYIHSEPLGVVLVIGTWNYPFNL 120
            +V   L+ +E+              E  P   +D +LY +  PLGV   I  +N+P  +
Sbjct: 136 GDVFRGLQVVEHACSVTSLMMG----ETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191

Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
            +     A+  GN+ ++KPSE       LLA ++      D    I  G  E    + + 
Sbjct: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDH 251

Query: 181 FD--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238
            D   I + GS   G+ I    ++H   V   +G K+   V  + + +    ++    F 
Sbjct: 252 PDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFG 311

Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298
            +GQ C+A    +     +  + E ++ +         +   D G +I+ +  +RV  LI
Sbjct: 312 AAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLI 371

Query: 299 -----EGQKVAYGGT-----GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
                EG  +   G      G     ++ PTI+++V P     +EEIFGPVL ++   +L
Sbjct: 372 DSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETL 431

Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408
           +EAIQ +N         +F++N    +K       G V  N V + + L    F G  +S
Sbjct: 432 DEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN-VPIPVPLPMFSFTGSRSS 490

Query: 409 GMG--SYHGKKSFETFSHRRS 427
             G  +++GK+  + ++  ++
Sbjct: 491 FRGDTNFYGKQGIQFYTQLKT 511


>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
           sapiens]
          Length = 539

 Score = 92.0 bits (227), Expect = 1e-18
 Identities = 78/341 (22%), Positives = 153/341 (44%), Gaps = 14/341 (4%)

Query: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLY 163
           P+G+V +I  +N+P  +       A+  GN  + K +  +  ++  +  II + L+ +  
Sbjct: 184 PVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKL 243

Query: 164 P-----VINGGVPETTELLK-ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPC 217
           P     +  GG    T + K ER + + +TGST VGK +     +      LELGG +  
Sbjct: 244 PGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAI 303

Query: 218 YVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDA 276
              ++ DL +      +     +GQ C     +    SI +++V +LKK+  +   G   
Sbjct: 304 IAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPW 363

Query: 277 KKSRDYGRIISARHFQRVMGLI-----EGQKVAYGG-TGDAATRYIAPTILTDVDPQSPV 330
             +  YG + + +     +G +     EG  V YGG   D    Y+ PTI+T +   + +
Sbjct: 364 DPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASI 423

Query: 331 MQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAAN 389
              E F P+L +   ++ EE   + N+ ++ L+  +F+ +  ++ + +  + S  G+   
Sbjct: 424 AHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNV 483

Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430
           ++          FGG  ++G G   G  +++ +  R +C +
Sbjct: 484 NIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524


>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
           sapiens]
          Length = 563

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)

Query: 2   SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           S +++A++ A AA      +P+  R Q  L+A   L   +  E++        K    A 
Sbjct: 100 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 159

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
            +    +++   +  +   E    +P+   P T      ++    G V  I     PFN 
Sbjct: 160 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 212

Query: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
           T     + GA A  GN V+ KPS+ +   +  +  I+ +     L P I   VP    L 
Sbjct: 213 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 269

Query: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225
                  E    I +TGS    K +    A++L        +  E GGK+  +V ++ D+
Sbjct: 270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 329

Query: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284
           +          F   GQ C A   +    S+  QI  +L +        D   + D+G  
Sbjct: 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 387

Query: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334
              +I A+ F R+   +E  +       +A G   D+   ++ P I+   DPQ P+M+EE
Sbjct: 388 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 447

Query: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389
           IFGPVL +        +E +Q ++      L   +FS +  V+++   +   ++G    N
Sbjct: 448 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507

Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415
           D      +   PFGG   SG     G
Sbjct: 508 DKSTGSIVGQQPFGGARASGTNDKPG 533


>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
          Length = 503

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)

Query: 2   SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           S +++A++ A AA      +P+  R Q  L+A   L   +  E++        K    A 
Sbjct: 40  SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 99

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
            +    +++   +  +   E    +P+   P T      ++    G V  I     PFN 
Sbjct: 100 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 152

Query: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
           T     + GA A  GN V+ KPS+ +   +  +  I+ +     L P I   VP    L 
Sbjct: 153 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 209

Query: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225
                  E    I +TGS    K +    A++L        +  E GGK+  +V ++ D+
Sbjct: 210 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 269

Query: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284
           +          F   GQ C A   +    S+  QI  +L +        D   + D+G  
Sbjct: 270 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 327

Query: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334
              +I A+ F R+   +E  +       +A G   D+   ++ P I+   DPQ P+M+EE
Sbjct: 328 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 387

Query: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389
           IFGPVL +        +E +Q ++      L   +FS +  V+++   +   ++G    N
Sbjct: 388 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 447

Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415
           D      +   PFGG   SG     G
Sbjct: 448 DKSTGSIVGQQPFGGARASGTNDKPG 473


>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
           sapiens]
          Length = 563

 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)

Query: 2   SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60
           S +++A++ A AA      +P+  R Q  L+A   L   +  E++        K    A 
Sbjct: 100 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 159

Query: 61  YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
            +    +++   +  +   E    +P+   P T      ++    G V  I     PFN 
Sbjct: 160 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 212

Query: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
           T     + GA A  GN V+ KPS+ +   +  +  I+ +     L P I   VP    L 
Sbjct: 213 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 269

Query: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225
                  E    I +TGS    K +    A++L        +  E GGK+  +V ++ D+
Sbjct: 270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 329

Query: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284
           +          F   GQ C A   +    S+  QI  +L +        D   + D+G  
Sbjct: 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 387

Query: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334
              +I A+ F R+   +E  +       +A G   D+   ++ P I+   DPQ P+M+EE
Sbjct: 388 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 447

Query: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389
           IFGPVL +        +E +Q ++      L   +FS +  V+++   +   ++G    N
Sbjct: 448 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507

Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415
           D      +   PFGG   SG     G
Sbjct: 508 DKSTGSIVGQQPFGGARASGTNDKPG 533


>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
           [Homo sapiens]
          Length = 802

 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 87/429 (20%), Positives = 166/429 (38%), Gaps = 48/429 (11%)

Query: 4   ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63
           ++ AV+ AR AF      P   R Q L  L  +IQ+ ++ L            W      
Sbjct: 79  VAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLL------------WTLESLV 126

Query: 64  VVYVLEEIE----YMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119
               + E+      + Q+L  + A +       + Q+E     EP+GV+ +I    + F 
Sbjct: 127 TGRAVREVRDGDVQLAQQLLHYHAIQA------STQEEALAGWEPMGVIGLILPPTFSFL 180

Query: 120 LTIQPMVGAIAAGNSVV--LKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
             +  +  A+A G +VV  + P+  +  + + LA  +  +    +  V++G       L 
Sbjct: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPF--PGILNVLSGPASLVPILA 238

Query: 178 KER-FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
            +     + + G+   G+ +  + A     + L LG +S   +    D+D A   +    
Sbjct: 239 SQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAA 298

Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKS---LKEFYGEDAKKSRDYGRIISARHFQR 293
           + + G   +    +L   S+ ++ + +L++    L+   G D           +    QR
Sbjct: 299 WSDRGPGGLR---LLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQR 355

Query: 294 VMGLIEGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
            +   + Q       GD  +   +  PT+++++ P SP  Q E+  PV+     R+ +EA
Sbjct: 356 FVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEA 415

Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH-----SLPFGGVG 406
           +   N   +         +  V  + + +    G       V I  H     S+P GG  
Sbjct: 416 LLVANGTPR-------GGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCK 468

Query: 407 NSGMGSYHG 415
            SG  S+HG
Sbjct: 469 ESGC-SWHG 476



 Score = 37.7 bits (86), Expect = 0.022
 Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 10/116 (8%)

Query: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSE----LSENMASLLATIIPQYL 158
           EPLGV+ V+    +P    +  +  A+A GN+VV+ PS     L+  +   +AT+ P   
Sbjct: 659 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFP--- 715

Query: 159 DKDLYPVINGGVPETTELLKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELG 212
              L  V+ G     T  L    D   + Y GS    + +  A+A +L PV    G
Sbjct: 716 -AGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 770


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,281,236
Number of Sequences: 37866
Number of extensions: 781051
Number of successful extensions: 2250
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2149
Number of HSP's gapped (non-prelim): 56
length of query: 453
length of database: 18,247,518
effective HSP length: 106
effective length of query: 347
effective length of database: 14,233,722
effective search space: 4939101534
effective search space used: 4939101534
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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