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Search of human proteins with 22902126
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor
[Homo sapiens]
(1030 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 2097 0.0
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 2077 0.0
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [... 1922 0.0
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 1134 0.0
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 238 2e-62
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 231 3e-60
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 231 3e-60
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 230 6e-60
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 230 6e-60
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 228 2e-59
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 227 4e-59
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 227 4e-59
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 224 2e-58
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 224 2e-58
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 223 6e-58
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 221 3e-57
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 221 4e-57
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 220 5e-57
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 220 6e-57
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 219 8e-57
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 219 1e-56
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 219 1e-56
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 217 4e-56
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 217 5e-56
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo... 216 9e-56
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 216 1e-55
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 216 1e-55
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 214 3e-55
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 212 1e-54
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 211 4e-54
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
sapiens]
Length = 1030
Score = 2097 bits (5432), Expect = 0.0
Identities = 1030/1030 (100%), Positives = 1030/1030 (100%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
Query: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
Query: 481 CMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQI 540
CMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQI
Sbjct: 481 CMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQI 540
Query: 541 RAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR 600
RAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR
Sbjct: 541 RAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR 600
Query: 601 MHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYK 660
MHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYK
Sbjct: 601 MHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYK 660
Query: 661 MIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPS 720
MIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPS
Sbjct: 661 MIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPS 720
Query: 721 AEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEE 780
AEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEE
Sbjct: 721 AEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEE 780
Query: 781 GVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDL 840
GVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDL
Sbjct: 781 GVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDL 840
Query: 841 GDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA 900
GDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA
Sbjct: 841 GDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA 900
Query: 901 QRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVF 960
QRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVF
Sbjct: 901 QRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVF 960
Query: 961 THGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASA 1020
THGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASA
Sbjct: 961 THGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASA 1020
Query: 1021 LGDSTVDSKP 1030
LGDSTVDSKP
Sbjct: 1021 LGDSTVDSKP 1030
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
sapiens]
Length = 1070
Score = 2077 bits (5381), Expect = 0.0
Identities = 1030/1070 (96%), Positives = 1030/1070 (96%), Gaps = 40/1070 (3%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
Query: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
Query: 481 CMSSTPAGSIEAQARVQVL----------------------------------------D 500
CMSSTPAGSIEAQARVQVL D
Sbjct: 481 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
Query: 501 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 560
GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
Sbjct: 541 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
Query: 561 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 620
TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG
Sbjct: 601 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 660
Query: 621 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 680
RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
Sbjct: 661 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 720
Query: 681 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 740
GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
Sbjct: 721 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 780
Query: 741 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 800
KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
Sbjct: 781 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 840
Query: 801 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 860
LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
Sbjct: 841 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 900
Query: 861 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 920
PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
Sbjct: 901 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 960
Query: 921 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 980
YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
Sbjct: 961 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 1020
Query: 981 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1030
AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 1021 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1070
>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
sapiens]
Length = 1014
Score = 1922 bits (4978), Expect = 0.0
Identities = 970/1070 (90%), Positives = 971/1070 (90%), Gaps = 96/1070 (8%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
Query: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421 SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
Query: 481 CMSSTPAGSIEAQARVQVL----------------------------------------D 500
CMSSTPAGSIEAQARVQVL D
Sbjct: 481 CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540
Query: 501 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 560
GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
Sbjct: 541 GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600
Query: 561 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 620
TTVYQGHTALLQCEAQGDPKPLIQWK K PE+S
Sbjct: 601 TTVYQGHTALLQCEAQGDPKPLIQWKDKP-------------------------VPEES- 634
Query: 621 RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 680
EGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
Sbjct: 635 ------------------------------EGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 664
Query: 681 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 740
GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
Sbjct: 665 GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 724
Query: 741 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 800
KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
Sbjct: 725 KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 784
Query: 801 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 860
LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
Sbjct: 785 LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 844
Query: 861 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 920
PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
Sbjct: 845 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 904
Query: 921 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 980
YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
Sbjct: 905 YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 964
Query: 981 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1030
AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 965 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1014
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [Homo
sapiens]
Length = 940
Score = 1134 bits (2933), Expect = 0.0
Identities = 623/926 (67%), Positives = 681/926 (73%), Gaps = 42/926 (4%)
Query: 129 VVLKHPASEAEIQPQTQVTLRCHIDGHPRPTY-QWFRDGTPLSDGQSNHTVSSKERNLTL 187
V +K P+S+ +Q + + LRC ++ P P + W DG P+ D + S +
Sbjct: 33 VFIKQPSSQDALQGR-RALLRCEVEA-PGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAV 90
Query: 188 RPAGPEHSGLYSCCAHS-AFGQACSSQNFTLSIADESFARVVLA--PQDVVVARYEEAMF 244
+ SG + C A G+ S N + +I VVL + + +
Sbjct: 91 DRL--QDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTL 148
Query: 245 HCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQ 304
C P P+ QW F D TP+++ +L L P ++G+Y C
Sbjct: 149 RCHIDGHPRPTYQW-FRDGTPLSDGQS----NHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
Query: 305 GQRGPPIILEA-TLHLAE--IEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEH--- 358
G + TL +A+ + L V A EE + P PS+ W
Sbjct: 204 SAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDE 263
Query: 359 ---AGVRLPTHGR---VYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVP 412
P H R V+ G L+L + +AG+Y C GQR + I AT+
Sbjct: 264 TPITNRSRPPHLRRATVFANG-SLLLTQVRPRNAGIYRCIGQ---GQRGPPI-ILEATLH 318
Query: 413 SWLKKPQDSQLEE------GKPGYLDCLT-QATPKPTVVWYRNQMLISEDSRFEVFKNG- 464
L + +D L E G + CL + P+P+V W + + R V++ G
Sbjct: 319 --LAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGR--VYQKGH 374
Query: 465 TLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDD 524
L + ++ D Y C ++ AG + V +GSSLPEWVTDNAGTLHFARVTRDD
Sbjct: 375 ELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDD 434
Query: 525 AGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQ 584
AGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQ
Sbjct: 435 AGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQ 494
Query: 585 WKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK 644
WKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK
Sbjct: 495 WKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK 554
Query: 645 PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP 704
PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP
Sbjct: 555 PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP 614
Query: 705 EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGK 764
EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGK
Sbjct: 615 EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGK 674
Query: 765 SEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGL 824
SEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGL
Sbjct: 675 SEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGL 734
Query: 825 CREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNN 884
CREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNN
Sbjct: 735 CREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNN 794
Query: 885 RFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFS 944
RFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFS
Sbjct: 795 RFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFS 854
Query: 945 TKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW 1004
TKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW
Sbjct: 855 TKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW 914
Query: 1005 ALSPKDRPSFSEIASALGDSTVDSKP 1030
ALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 915 ALSPKDRPSFSEIASALGDSTVDSKP 940
Score = 854 bits (2207), Expect = 0.0
Identities = 433/553 (78%), Positives = 453/553 (81%), Gaps = 53/553 (9%)
Query: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1 MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
Query: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61 VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA---TVPSWLK- 416
VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA ++P W+
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTD 420
Query: 417 ----------------------------------------------KPQDSQLEEGKPGY 430
+P+ + + +G
Sbjct: 421 NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTAL 480
Query: 431 LDCLTQATPKPTVVWYRNQMLISEDS---RFEVFKNGTLRINSVEVYDGTWYRCMSSTPA 487
L C Q PKP + W ++ R +F+NG+L I+ V D Y C++
Sbjct: 481 LQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC 540
Query: 488 GSIEAQARVQVLD 500
+A + V+D
Sbjct: 541 NIKHTEAPLYVVD 553
Score = 33.9 bits (76), Expect = 0.81
Identities = 31/116 (26%), Positives = 43/116 (37%), Gaps = 19/116 (16%)
Query: 552 ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVI 611
I F +P QG ALL+CE + + W +LD + F GS +
Sbjct: 32 IVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLS 86
Query: 612 HDVAP--EDSGRYTCIAGN------------SCNIKHTEAPLYVVDKPVPEESEGP 653
+DSG + C+A + S NIK EA V+ P E P
Sbjct: 87 FAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQP 142
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 238 bits (608), Expect = 2e-62
Identities = 209/753 (27%), Positives = 321/753 (42%), Gaps = 111/753 (14%)
Query: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
E VF +G ++C PP G P W G L RV L + N + D+G
Sbjct: 47 EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106
Query: 389 YTCHAANLAGQRRQDVNITVATVPS------WLKKPQDSQLEEGKPGY-----LDCLTQA 437
Y+C L + ++ V PS + +D+ ++ G P + +D A
Sbjct: 107 YSCRQ-RLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLA 165
Query: 438 TPKPTVVWYRNQMLISEDSRFEVFKNGTL-----RINSVEVYDGTWYRCMSSTPAGSIEA 492
P V +R + KNG RI +++ W M S
Sbjct: 166 VPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMES-------- 217
Query: 493 QARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFI 552
V D GNYTC+ N G IR L V
Sbjct: 218 ---------------------------VVPSDRGNYTCVVEN-KFGSIRQTYTLDVLERS 249
Query: 553 TFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHI 603
+ P T G C+ D +P IQW K ++ +K+GP + +
Sbjct: 250 PHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL-KHVEVNGSKVGPDGTPYVTV 308
Query: 604 FQNGS----------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEES-EG 652
+ L +H+V ED+G YTC+AGNS H A L V+ P EE E
Sbjct: 309 LKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVL--PAEEELVEA 366
Query: 653 PGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKR---------LQKQPEGEE 703
+ Y I LS G I V+ + C+ R K+ + + P +
Sbjct: 367 DEAGSVYAGI----LSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQ 422
Query: 704 PEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRH---STSDKMHFPRSSLQPIT 760
+E + + + P I A S G GP N K R+ L
Sbjct: 423 VSLE--SNASMSSNTPLVRI----ARLSSGEGPTLANVSELELPADPKWELSRARLTLGK 476
Query: 761 TLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HA 816
LG+ FG+V +A+A G+++ A V V KD+ D E+EM + H
Sbjct: 477 PLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHK 536
Query: 817 NVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDE-KLKSQPLSTKQKVA 869
N++ LLG C + P Y+++EY G+L++FLR + S D K + L+ K V+
Sbjct: 537 NIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVS 596
Query: 870 LCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWV 928
QVA GME+L++ + +H+DLAARN LV+ +K++ GL++DV+N +YY +
Sbjct: 597 CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRL 656
Query: 929 PLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ 988
P++WM+PEA+ + ++ +SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+ +
Sbjct: 657 PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDK 715
Query: 989 PEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
P C LY +M+ CW +P RP+F ++ L
Sbjct: 716 PANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 748
Score = 53.5 bits (127), Expect = 1e-06
Identities = 55/259 (21%), Positives = 90/259 (34%), Gaps = 48/259 (18%)
Query: 37 QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
+P Q+ L G L C GP+ W+ DG + +ER L
Sbjct: 42 EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101
Query: 93 LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
+DSG + C R DD GE+ ++ G
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154
Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
P + + V RC G+P P+ W ++G + + H + ++
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211
Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
+L + P G Y+C + FG Q +TL + + S R +L P +
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
Query: 241 EAMFHCQFSAQPPPSLQWL 259
+ FHC+ + P +QWL
Sbjct: 270 DVEFHCKVYSDAQPHIQWL 288
Score = 34.7 bits (78), Expect = 0.48
Identities = 66/294 (22%), Positives = 97/294 (32%), Gaps = 62/294 (21%)
Query: 154 GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQ 213
G P W +DGT L + V + L + A E SG YSC C
Sbjct: 66 GGPMGPTVWVKDGTGLVPSER---VLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC--- 119
Query: 214 NFTLSIAD-------------------ESFARVVLAPQDV-----VVARYEEAMFHCQFS 249
+F++ + D ++ A P+ + V F C +
Sbjct: 120 HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAA 179
Query: 250 AQPPPSLQWLFED-ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
P PS+ WL E +R LR SL++ V P + G Y C+ + + G
Sbjct: 180 GNPTPSISWLKNGREFRGEHRIGGIKLRHQ----QWSLVMESVVPSDRGNYTCVVENKFG 235
Query: 309 PPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA- 359
+ T L +E P L + GS+ C W +H
Sbjct: 236 S---IRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVE 292
Query: 360 --GVRLPTHGRVY-------------QKGHELVLANIAESDAGVYTCHAANLAG 398
G ++ G Y ++ L L N+ DAG YTC A N G
Sbjct: 293 VNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG 346
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 231 bits (589), Expect = 3e-60
Identities = 200/748 (26%), Positives = 319/748 (42%), Gaps = 137/748 (18%)
Query: 353 SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA--- 409
S+ W GV+L R G E+ + + +D+G+Y C ++ +G ++ V+
Sbjct: 63 SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122
Query: 410 --------------------------TVPSWLKKPQDSQLEEGKPGY----LDCLTQATP 439
P W + + P C + TP
Sbjct: 123 PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 182
Query: 440 KPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVL 499
PT+ W +N D R I +V TW M S
Sbjct: 183 NPTLRWLKNGKEFKPDHR----------IGGYKVRYATWSIIMDS--------------- 217
Query: 500 DGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVE-- 557
V D GNYTCI N G I QL V +
Sbjct: 218 --------------------VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERSPHRPILQ 256
Query: 558 ---PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGSL- 609
P TV G C+ DP+P IQW K ++ +K+GP + I + +
Sbjct: 257 AGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQILKTAGVN 315
Query: 610 -------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYK 660
V+H +V+ ED+G YTC+AGNS + H A L V++ EE + P Y
Sbjct: 316 TTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE--ALEERPAVMTSPLYL 373
Query: 661 MIQT-------IGLSVGAAVAYII------AVLGLMFYCKKRCKAKRLQKQPEGEEPEME 707
I I VG+ + Y + + K K+ L++Q
Sbjct: 374 EIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSA 433
Query: 708 CLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--KMHFPRSSLQPITTLGKS 765
+N G L + L+S G+ A + + + PR L LG+
Sbjct: 434 SMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEG 485
Query: 766 EFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVVRL 821
FG+V LA+A GL++ T V VK L+S ++ L D E+EM + H N++ L
Sbjct: 486 CFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINL 545
Query: 822 LGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQKVALCTQV 874
LG C + P Y+++EY G+L+++L+ + + P LS+K V+ QV
Sbjct: 546 LGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQV 605
Query: 875 ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWM 933
A GME+L++ + +H+DLAARN LV+ +K++ GL++D+++ +YY +P++WM
Sbjct: 606 ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWM 665
Query: 934 SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 993
+PEA+ + ++ +SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+ +P C
Sbjct: 666 APEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSNCT 724
Query: 994 SKLYRLMQRCWALSPKDRPSFSEIASAL 1021
++LY +M+ CW P RP+F ++ L
Sbjct: 725 NELYMMMRDCWHAVPSQRPTFKQLVEDL 752
Score = 50.8 bits (120), Expect = 6e-06
Identities = 76/327 (23%), Positives = 121/327 (37%), Gaps = 73/327 (22%)
Query: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
+ P + LRC + + + W RDG L++ SN T + E + ++ + P SGLY+
Sbjct: 45 VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100
Query: 200 CCAHSAFGQACSSQNFTLSIAD--------------------------ESFARVVLAPQD 233
C S G + F+++++D A +P+
Sbjct: 101 CVTSSPSGS--DTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEK 158
Query: 234 V-----VVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
+ V + F C S P P+L+WL + +P H +A S+
Sbjct: 159 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 213
Query: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
++ V P + G Y CI + + G + T L +E P L + GS
Sbjct: 214 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270
Query: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
C P+P + W +H V L T G K E++ L N+
Sbjct: 271 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 329
Query: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
+ DAG YTC A N G +TV
Sbjct: 330 SFEDAGEYTCLAGNSIGLSHHSAWLTV 356
Score = 47.4 bits (111), Expect = 7e-05
Identities = 54/248 (21%), Positives = 87/248 (35%), Gaps = 49/248 (19%)
Query: 48 RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
R LR +V++ + WL DG + ++ R G + D + DSG + CV
Sbjct: 54 RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106
Query: 105 -------------------------DDVTGEEARSANASFNIK---WIEAGPVVLKHPAS 136
DD + EE + N N W + K A
Sbjct: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAV 166
Query: 137 EAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEH 194
A V +C G P PT +W ++G + V ++ + P
Sbjct: 167 PAA----KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 222
Query: 195 SGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQ 251
G Y+C + +G + + L + + S R +L P + VA F C+ +
Sbjct: 223 KGNYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 280
Query: 252 PPPSLQWL 259
P P +QWL
Sbjct: 281 PQPHIQWL 288
>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
[Homo sapiens]
Length = 822
Score = 231 bits (588), Expect = 3e-60
Identities = 202/750 (26%), Positives = 323/750 (43%), Gaps = 139/750 (18%)
Query: 353 SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA-TV 411
S+ W GV+L R G E+ + + +D+G+Y C ++ +G ++ V+ +
Sbjct: 63 SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122
Query: 412 PSWLKKPQDS-------QLEEGKPGYLD---------------------------CLTQA 437
PS D + + KP + C +
Sbjct: 123 PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 182
Query: 438 TPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQ 497
TP PT+ W +N D R I +V TW M S
Sbjct: 183 TPNPTLRWLKNGKEFKPDHR----------IGGYKVRYATWSIIMDS------------- 219
Query: 498 VLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVE 557
V D GNYTCI N G I QL V +
Sbjct: 220 ----------------------VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERSPHRPI 256
Query: 558 -----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS 608
P TV G C+ DP+P IQW K ++ +K+GP + I +
Sbjct: 257 LQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQILKTAG 315
Query: 609 L--------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPP 658
+ V+H +V+ ED+G YTC+AGNS + H A L V++ EE + P
Sbjct: 316 VNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE--ALEERPAVMTSPL 373
Query: 659 YKMIQT-------IGLSVGAAVAYII------AVLGLMFYCKKRCKAKRLQKQPEGEEPE 705
Y I I VG+ + Y + + K K+ L++Q
Sbjct: 374 YLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADS 433
Query: 706 MECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--KMHFPRSSLQPITTLG 763
+N G L + L+S G+ A + + + PR L LG
Sbjct: 434 SASMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLG 485
Query: 764 KSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVV 819
+ FG+V LA+A GL++ T V VK L+S ++ L D E+EM + H N++
Sbjct: 486 EGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNII 545
Query: 820 RLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQKVALCT 872
LLG C + P Y+++EY G+L+++L+ + + P LS+K V+
Sbjct: 546 NLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAY 605
Query: 873 QVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLR 931
QVA GME+L++ + +H+DLAARN LV+ +K++ GL++D+++ +YY +P++
Sbjct: 606 QVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVK 665
Query: 932 WMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEG 991
WM+PEA+ + ++ +SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+ +P
Sbjct: 666 WMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSN 724
Query: 992 CPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
C ++LY +M+ CW P RP+F ++ L
Sbjct: 725 CTNELYMMMRDCWHAVPSQRPTFKQLVEDL 754
Score = 52.8 bits (125), Expect = 2e-06
Identities = 79/327 (24%), Positives = 124/327 (37%), Gaps = 71/327 (21%)
Query: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
+ P + LRC + + + W RDG L++ SN T + E + ++ + P SGLY+
Sbjct: 45 VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100
Query: 200 CCAHSAFGQACSSQNFTLSIA----------DESFA-----------RVVLAPQDVVVAR 238
C S G + + +S A D+S + R+ +AP +
Sbjct: 101 CVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 160
Query: 239 YEEAM----------FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
E+ + F C S P P+L+WL + +P H +A S+
Sbjct: 161 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 215
Query: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
++ V P + G Y CI + + G + T L +E P L + GS
Sbjct: 216 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 272
Query: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
C P+P + W +H V L T G K E++ L N+
Sbjct: 273 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331
Query: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
+ DAG YTC A N G +TV
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTV 358
Score = 47.0 bits (110), Expect = 9e-05
Identities = 51/246 (20%), Positives = 87/246 (35%), Gaps = 43/246 (17%)
Query: 48 RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
R LR +V++ + WL DG + ++ R G + D + DSG + CV
Sbjct: 54 RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106
Query: 105 -------------------------DDVTGEEARSANASFNIKWIEAGPVVLKHPASEAE 139
DD + EE + N N + + +
Sbjct: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLH 166
Query: 140 IQPQTQ-VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSG 196
P + V +C G P PT +W ++G + V ++ + P G
Sbjct: 167 AVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKG 226
Query: 197 LYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPP 253
Y+C + +G + + L + + S R +L P + VA F C+ + P
Sbjct: 227 NYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 284
Query: 254 PSLQWL 259
P +QWL
Sbjct: 285 PHIQWL 290
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 230 bits (586), Expect = 6e-60
Identities = 213/757 (28%), Positives = 339/757 (44%), Gaps = 72/757 (9%)
Query: 308 GPPII-LEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK----GLPEPSVWWEHAGVR 362
GPP++ LEA+ E+E P P + E V P G E W G R
Sbjct: 16 GPPVLSLEAS---EEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSR 72
Query: 363 LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQ 422
L GRV L +A+ DAG Y C A G N+T+ T S D
Sbjct: 73 LAPAGRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTLITGDSLTSSNDD-- 127
Query: 423 LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCM 482
E+ K + P+ W Q + ++++V + +RC
Sbjct: 128 -EDPKSHRDPSNRHSYPQQAPYWTHPQRMEK-------------KLHAVPAGNTVKFRCP 173
Query: 483 SS-TPAGSIEAQARVQVLDGSSLPEWVT--DNAGTLHFARVTRDDAGNYTCIASNGPQGQ 539
++ P +I Q G + + +L V D G YTC+ N G
Sbjct: 174 AAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAV-GS 232
Query: 540 IRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDP 594
IR + L V + P TT G L C+ D +P IQW K +++
Sbjct: 233 IRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL-KHIVING 291
Query: 595 TKLG----PRMHIFQNGS--------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 642
+ G P + + + L + +V+ ED+G YTC+AGNS + + A L V+
Sbjct: 292 SSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL 351
Query: 643 DKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL--GLMFYCKKRCKAKRLQKQPE 700
+ P + +I S+ AV ++A L G + + +QK
Sbjct: 352 PEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSR 411
Query: 701 GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM----HFPRSSL 756
L G +G+ S+ + V L+S SGPA S + FPR L
Sbjct: 412 FPLARQFSLESG--SSGKSSSSLVRGVRLSS--SGPALLAGLVSLDLPLDPLWEFPRDRL 467
Query: 757 QPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKL 813
LG+ FG+V A+A G++ + + V VK L+ + L D E+E+ +
Sbjct: 468 VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLI 527
Query: 814 N-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDEKLKSQ-PLSTK 865
H N++ LLG+C + P Y+++E G+L++FLR + S D S+ PLS
Sbjct: 528 GRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFP 587
Query: 866 QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FR 924
V+ QVA GM++L + + +H+DLAARN LV+ +K++ GL++ V++ +YY
Sbjct: 588 VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS 647
Query: 925 QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA 984
+P++WM+PEA+ + ++ +SDVW+FG+L+WE+FT G P+ G +E+ + L+ G
Sbjct: 648 NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH- 706
Query: 985 RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
R+ +P CP +LY LM+ CW +P RP+F ++ AL
Sbjct: 707 RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743
Score = 44.3 bits (103), Expect = 6e-04
Identities = 46/212 (21%), Positives = 74/212 (34%), Gaps = 26/212 (12%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W +DG + + + +L + P G Y+C
Sbjct: 168 VKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVE 227
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWLF 260
+A G N+ L + + S R +L P + + C+ + P +QWL
Sbjct: 228 NAVGSI--RYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLK 285
Query: 261 E----------DETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP 310
D P + + + V L L V +AG Y C+ G
Sbjct: 286 HIVINGSSFGADGFPYVQVLKTADINSSEVEV---LYLRNVSAEDAGEYTCLAGNSIG-- 340
Query: 311 IILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
+ A + +P +P A E R T
Sbjct: 341 ----LSYQSAWLTVLPEEDPTWTAAAPEARYT 368
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 230 bits (586), Expect = 6e-60
Identities = 213/757 (28%), Positives = 339/757 (44%), Gaps = 72/757 (9%)
Query: 308 GPPII-LEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK----GLPEPSVWWEHAGVR 362
GPP++ LEA+ E+E P P + E V P G E W G R
Sbjct: 16 GPPVLSLEAS---EEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSR 72
Query: 363 LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQ 422
L GRV L +A+ DAG Y C A G N+T+ T S D
Sbjct: 73 LAPAGRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTLITGDSLTSSNDD-- 127
Query: 423 LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCM 482
E+ K + P+ W Q + ++++V + +RC
Sbjct: 128 -EDPKSHRDPSNRHSYPQQAPYWTHPQRMEK-------------KLHAVPAGNTVKFRCP 173
Query: 483 SS-TPAGSIEAQARVQVLDGSSLPEWVT--DNAGTLHFARVTRDDAGNYTCIASNGPQGQ 539
++ P +I Q G + + +L V D G YTC+ N G
Sbjct: 174 AAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAV-GS 232
Query: 540 IRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDP 594
IR + L V + P TT G L C+ D +P IQW K +++
Sbjct: 233 IRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL-KHIVING 291
Query: 595 TKLG----PRMHIFQNGS--------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 642
+ G P + + + L + +V+ ED+G YTC+AGNS + + A L V+
Sbjct: 292 SSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL 351
Query: 643 DKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL--GLMFYCKKRCKAKRLQKQPE 700
+ P + +I S+ AV ++A L G + + +QK
Sbjct: 352 PEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSR 411
Query: 701 GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM----HFPRSSL 756
L G +G+ S+ + V L+S SGPA S + FPR L
Sbjct: 412 FPLARQFSLESG--SSGKSSSSLVRGVRLSS--SGPALLAGLVSLDLPLDPLWEFPRDRL 467
Query: 757 QPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKL 813
LG+ FG+V A+A G++ + + V VK L+ + L D E+E+ +
Sbjct: 468 VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLI 527
Query: 814 N-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDEKLKSQ-PLSTK 865
H N++ LLG+C + P Y+++E G+L++FLR + S D S+ PLS
Sbjct: 528 GRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFP 587
Query: 866 QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FR 924
V+ QVA GM++L + + +H+DLAARN LV+ +K++ GL++ V++ +YY
Sbjct: 588 VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS 647
Query: 925 QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA 984
+P++WM+PEA+ + ++ +SDVW+FG+L+WE+FT G P+ G +E+ + L+ G
Sbjct: 648 NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH- 706
Query: 985 RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
R+ +P CP +LY LM+ CW +P RP+F ++ AL
Sbjct: 707 RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743
Score = 44.3 bits (103), Expect = 6e-04
Identities = 46/212 (21%), Positives = 74/212 (34%), Gaps = 26/212 (12%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W +DG + + + +L + P G Y+C
Sbjct: 168 VKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVE 227
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWLF 260
+A G N+ L + + S R +L P + + C+ + P +QWL
Sbjct: 228 NAVGSI--RYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLK 285
Query: 261 E----------DETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP 310
D P + + + V L L V +AG Y C+ G
Sbjct: 286 HIVINGSSFGADGFPYVQVLKTADINSSEVEV---LYLRNVSAEDAGEYTCLAGNSIG-- 340
Query: 311 IILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
+ A + +P +P A E R T
Sbjct: 341 ----LSYQSAWLTVLPEEDPTWTAAAPEARYT 368
>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
[Homo sapiens]
Length = 821
Score = 228 bits (581), Expect = 2e-59
Identities = 195/752 (25%), Positives = 325/752 (43%), Gaps = 99/752 (13%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
+G+Y C A+ + V S E+ G D +++ + +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAIS------SGDDEDDTDGAEDFVSENSNNKRAPY 155
Query: 446 YRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
+ N + + R+++V + +RC PAG + +G
Sbjct: 156 WTNTEKMEK------------RLHAVPAANTVKFRC----PAGGNPMPTMRWLKNGKEFK 199
Query: 506 EW-------VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FI 552
+ V + +L V D GNYTC+ N G I L V +
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPIL 258
Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS 608
+ +TV G + C+ D +P IQW K + +K GP + + +
Sbjct: 259 QAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAG 316
Query: 609 ----------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPP 658
L I +V ED+G YTC+AGNS I A L V+ P P + + P
Sbjct: 317 VNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPD 374
Query: 659 YKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNG 717
Y I + V ++ V+ C+ K K+P+ +P + L
Sbjct: 375 YLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRR 426
Query: 718 QPSAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITT 761
Q + + ++ S T + ST+D K FPR L
Sbjct: 427 QVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKP 486
Query: 762 LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HAN 817
LG+ FG+V +A+A G+++ + V V KD+ + D E+EM + H N
Sbjct: 487 LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 546
Query: 818 VVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVAL 870
++ LLG C + P Y+++EY G+L+++LR + ++ + ++ K V+
Sbjct: 547 IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 606
Query: 871 CTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVP 929
Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY +P
Sbjct: 607 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 666
Query: 930 LRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQP 989
++WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G R+ +P
Sbjct: 667 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKP 725
Query: 990 EGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
C ++LY +M+ CW P RP+F ++ L
Sbjct: 726 ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 757
Score = 47.0 bits (110), Expect = 9e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
Score = 43.5 bits (101), Expect = 0.001
Identities = 79/343 (23%), Positives = 118/343 (34%), Gaps = 82/343 (23%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261
Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQKG--------- 373
L G + C +P + W E G + G Y K
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTT 320
Query: 374 ----HELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVP 412
L + N+ DAG YTC A N G +TV P
Sbjct: 321 DKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAP 363
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
[Homo sapiens]
Length = 790
Score = 227 bits (579), Expect = 4e-59
Identities = 174/587 (29%), Positives = 270/587 (45%), Gaps = 50/587 (8%)
Query: 470 SVEVYDGTWYRCMSS----TPAGSI--EAQARVQVLDGSSLPEWVTDNAGTLHFARVTRD 523
SV+V D RC AG I E + V+ LP L A VT D
Sbjct: 204 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL------GLTLANVTSD 257
Query: 524 -DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPL 582
+ N TC A N +++V V ++F + T + H + G P P
Sbjct: 258 LNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPS 312
Query: 583 IQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHT 635
++W +L+ T L P + ++G L ++ ++G YT +A N
Sbjct: 313 LRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASA 372
Query: 636 EAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA-----YIIAVLGL 682
+D P +P+ + G P K G+SV +A ++ +L +
Sbjct: 373 SIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLV 432
Query: 683 MFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKR 742
+ C +R K +P PE S+ E + L +
Sbjct: 433 LNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQY 490
Query: 743 HSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD 802
S + H R + LG+ FG+VFLA+ L + LV VK+L+ E + D
Sbjct: 491 FSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD 550
Query: 803 FRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKS--- 859
F+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S D KL +
Sbjct: 551 FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGPDAKLLAGGE 609
Query: 860 ----QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV 915
PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+ G+S+D+
Sbjct: 610 DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI 669
Query: 916 YNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDE 974
Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+ P ++ E
Sbjct: 670 YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE 729
Query: 975 VLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
+ + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 730 AIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 775
Score = 40.0 bits (92), Expect = 0.011
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
G LLRC+VE G W+L T + SL + D C A
Sbjct: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
Query: 210 CSS 212
+S
Sbjct: 371 SAS 373
Score = 30.8 bits (68), Expect = 6.9
Identities = 31/139 (22%), Positives = 53/139 (38%), Gaps = 21/139 (15%)
Query: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
L LAN+ ++ + TC A N G+ V + V+ P QL + C+
Sbjct: 249 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 301
Query: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
P P++ W N +++E S E ++G LR+N + Y
Sbjct: 302 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 361
Query: 482 MSSTPAGSIEAQARVQVLD 500
+++ P G A +D
Sbjct: 362 LAANPFGQASASIMAAFMD 380
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
[Homo sapiens]
Length = 760
Score = 227 bits (579), Expect = 4e-59
Identities = 174/587 (29%), Positives = 270/587 (45%), Gaps = 50/587 (8%)
Query: 470 SVEVYDGTWYRCMSS----TPAGSI--EAQARVQVLDGSSLPEWVTDNAGTLHFARVTRD 523
SV+V D RC AG I E + V+ LP L A VT D
Sbjct: 174 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL------GLTLANVTSD 227
Query: 524 -DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPL 582
+ N TC A N +++V V ++F + T + H + G P P
Sbjct: 228 LNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPS 282
Query: 583 IQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHT 635
++W +L+ T L P + ++G L ++ ++G YT +A N
Sbjct: 283 LRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASA 342
Query: 636 EAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA-----YIIAVLGL 682
+D P +P+ + G P K G+SV +A ++ +L +
Sbjct: 343 SIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLV 402
Query: 683 MFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKR 742
+ C +R K +P PE S+ E + L +
Sbjct: 403 LNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQY 460
Query: 743 HSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD 802
S + H R + LG+ FG+VFLA+ L + LV VK+L+ E + D
Sbjct: 461 FSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD 520
Query: 803 FRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKS--- 859
F+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S D KL +
Sbjct: 521 FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGPDAKLLAGGE 579
Query: 860 ----QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV 915
PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+ G+S+D+
Sbjct: 580 DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI 639
Query: 916 YNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDE 974
Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+ P ++ E
Sbjct: 640 YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE 699
Query: 975 VLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
+ + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 700 AIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 745
Score = 40.0 bits (92), Expect = 0.011
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
G LLRC+VE G W+L T + SL + D C A
Sbjct: 178 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 237
Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 238 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 280
Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 281 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 340
Query: 210 CSS 212
+S
Sbjct: 341 SAS 343
Score = 30.8 bits (68), Expect = 6.9
Identities = 31/139 (22%), Positives = 53/139 (38%), Gaps = 21/139 (15%)
Query: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
L LAN+ ++ + TC A N G+ V + V+ P QL + C+
Sbjct: 219 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 271
Query: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
P P++ W N +++E S E ++G LR+N + Y
Sbjct: 272 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 331
Query: 482 MSSTPAGSIEAQARVQVLD 500
+++ P G A +D
Sbjct: 332 LAANPFGQASASIMAAFMD 350
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 224 bits (572), Expect = 2e-58
Identities = 183/635 (28%), Positives = 286/635 (45%), Gaps = 104/635 (16%)
Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEA 492
C + TP PT+ W +N D R I +V TW M S
Sbjct: 87 CPSSGTPNPTLRWLKNGKEFKPDHR----------IGGYKVRYATWSIIMDS-------- 128
Query: 493 QARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFI 552
V D GNYTCI N G I QL V
Sbjct: 129 ---------------------------VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERS 160
Query: 553 TFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHI 603
+ P TV G C+ DP+P IQW K ++ +K+GP + I
Sbjct: 161 PHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQI 219
Query: 604 FQNGSL--------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGP 653
+ + V+H +V+ ED+G YTC+AGNS + H A L V++ EE
Sbjct: 220 LKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE--ALEERPAV 277
Query: 654 GSPPPYKMIQT-------IGLSVGAAVAYII------AVLGLMFYCKKRCKAKRLQKQPE 700
+ P Y I I VG+ + Y + + K K+ L++Q
Sbjct: 278 MTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVT 337
Query: 701 GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--KMHFPRSSLQP 758
+N G L + L+S G+ A + + + PR L
Sbjct: 338 VSADSSASMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 389
Query: 759 ITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN- 814
LG+ FG+V LA+A GL++ T V VK L+S ++ L D E+EM +
Sbjct: 390 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 449
Query: 815 HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQK 867
H N++ LLG C + P Y+++EY G+L+++L+ + + P LS+K
Sbjct: 450 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 509
Query: 868 VALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQA 926
V+ QVA GME+L++ + +H+DLAARN LV+ +K++ GL++D+++ +YY
Sbjct: 510 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 569
Query: 927 WVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARL 986
+P++WM+PEA+ + ++ +SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+
Sbjct: 570 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RM 628
Query: 987 PQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
+P C ++LY +M+ CW P RP+F ++ L
Sbjct: 629 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 663
Score = 46.2 bits (108), Expect = 2e-04
Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V +C G P PT +W ++G + V ++ + P G Y+C
Sbjct: 83 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 142
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + VA F C+ + P P +QWL
Sbjct: 143 NEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 199
Score = 44.7 bits (104), Expect = 5e-04
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 15/122 (12%)
Query: 555 KVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT-KLGPRMHIFQNGSLVIHD 613
K+E + V T +C + G P P ++W + P ++G + S+++
Sbjct: 69 KMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDS 128
Query: 614 VAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAA 672
V P D G YTCI N +I HT Y +D V E S P++ I GL
Sbjct: 129 VVPSDKGNYTCIVENEYGSINHT----YQLD--VVERS-------PHRPILQAGLPANKT 175
Query: 673 VA 674
VA
Sbjct: 176 VA 177
Score = 40.8 bits (94), Expect = 0.007
Identities = 50/192 (26%), Positives = 72/192 (37%), Gaps = 36/192 (18%)
Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSLLLTQVRPRNAGIYRC 301
F C S P P+L+WL + +P H +A S+++ V P + G Y C
Sbjct: 85 FKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 139
Query: 302 IGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPS 353
I + + G + T L +E P L + GS C P+P
Sbjct: 140 IVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD-PQPH 195
Query: 354 VWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANIAESDAGVYTCHAANL 396
+ W +H V L T G K E++ L N++ DAG YTC A N
Sbjct: 196 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS 255
Query: 397 AGQRRQDVNITV 408
G +TV
Sbjct: 256 IGLSHHSAWLTV 267
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 224 bits (572), Expect = 2e-58
Identities = 183/635 (28%), Positives = 286/635 (45%), Gaps = 104/635 (16%)
Query: 433 CLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEA 492
C + TP PT+ W +N D R I +V TW M S
Sbjct: 89 CPSSGTPNPTLRWLKNGKEFKPDHR----------IGGYKVRYATWSIIMDS-------- 130
Query: 493 QARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFI 552
V D GNYTCI N G I QL V
Sbjct: 131 ---------------------------VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERS 162
Query: 553 TFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHI 603
+ P TV G C+ DP+P IQW K ++ +K+GP + I
Sbjct: 163 PHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQI 221
Query: 604 FQNGSL--------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGP 653
+ + V+H +V+ ED+G YTC+AGNS + H A L V++ EE
Sbjct: 222 LKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE--ALEERPAV 279
Query: 654 GSPPPYKMIQT-------IGLSVGAAVAYII------AVLGLMFYCKKRCKAKRLQKQPE 700
+ P Y I I VG+ + Y + + K K+ L++Q
Sbjct: 280 MTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVT 339
Query: 701 GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--KMHFPRSSLQP 758
+N G L + L+S G+ A + + + PR L
Sbjct: 340 VSADSSASMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 391
Query: 759 ITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN- 814
LG+ FG+V LA+A GL++ T V VK L+S ++ L D E+EM +
Sbjct: 392 GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 451
Query: 815 HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQK 867
H N++ LLG C + P Y+++EY G+L+++L+ + + P LS+K
Sbjct: 452 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 511
Query: 868 VALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQA 926
V+ QVA GME+L++ + +H+DLAARN LV+ +K++ GL++D+++ +YY
Sbjct: 512 VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 571
Query: 927 WVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARL 986
+P++WM+PEA+ + ++ +SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+
Sbjct: 572 RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RM 630
Query: 987 PQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
+P C ++LY +M+ CW P RP+F ++ L
Sbjct: 631 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 665
Score = 46.2 bits (108), Expect = 2e-04
Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V +C G P PT +W ++G + V ++ + P G Y+C
Sbjct: 85 VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 144
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + VA F C+ + P P +QWL
Sbjct: 145 NEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 201
Score = 44.7 bits (104), Expect = 5e-04
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 15/122 (12%)
Query: 555 KVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT-KLGPRMHIFQNGSLVIHD 613
K+E + V T +C + G P P ++W + P ++G + S+++
Sbjct: 71 KMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDS 130
Query: 614 VAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAA 672
V P D G YTCI N +I HT Y +D V E S P++ I GL
Sbjct: 131 VVPSDKGNYTCIVENEYGSINHT----YQLD--VVERS-------PHRPILQAGLPANKT 177
Query: 673 VA 674
VA
Sbjct: 178 VA 179
Score = 40.8 bits (94), Expect = 0.007
Identities = 50/192 (26%), Positives = 72/192 (37%), Gaps = 36/192 (18%)
Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSLLLTQVRPRNAGIYRC 301
F C S P P+L+WL + +P H +A S+++ V P + G Y C
Sbjct: 87 FKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 141
Query: 302 IGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPS 353
I + + G + T L +E P L + GS C P+P
Sbjct: 142 IVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD-PQPH 197
Query: 354 VWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANIAESDAGVYTCHAANL 396
+ W +H V L T G K E++ L N++ DAG YTC A N
Sbjct: 198 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS 257
Query: 397 AGQRRQDVNITV 408
G +TV
Sbjct: 258 IGLSHHSAWLTV 269
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 223 bits (569), Expect = 6e-58
Identities = 175/593 (29%), Positives = 268/593 (45%), Gaps = 56/593 (9%)
Query: 470 SVEVYDGTWYRCMSS----TPAGSI--EAQARVQVLDGSSLPEWVTDNAGTLHFARVTRD 523
SV+V D RC AG I E + V+ LP L A VT D
Sbjct: 204 SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL------GLTLANVTSD 257
Query: 524 -DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPL 582
+ N TC A N +++V V ++F + T + H + G P P
Sbjct: 258 LNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPS 312
Query: 583 IQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHT 635
++W +L+ T L P + ++G L ++ ++G YT +A N
Sbjct: 313 LRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASA 372
Query: 636 EAPLYVVDKPVPEESEGP--------------GSPPPYKMIQTIGLSVGAAVA-----YI 676
+D P E P G P K G+SV +A ++
Sbjct: 373 SIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFL 432
Query: 677 IAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGP 736
+L ++ C +R K +P PE S+ E + L
Sbjct: 433 STLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHI 490
Query: 737 AATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKD 796
+ S + H R + LG+ FG+VFLA+ L + LV VK+L+
Sbjct: 491 IENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEAS 550
Query: 797 EQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEK 856
E + DF+RE E+ L H ++VR G+C E P MV EY+ GDL +FLR S D K
Sbjct: 551 ESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGPDAK 609
Query: 857 LKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL 909
L + PL Q +A+ +QVA GM +L+ FVH+DLA RNCLV VK+
Sbjct: 610 LLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDF 669
Query: 910 GLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHG 968
G+S+D+Y+++YY + +P+RWM PE+IL F+T+SDVW+FGV++WE+FT+G+ P
Sbjct: 670 GMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWY 729
Query: 969 GQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
++ E + + G+ L +P CP ++Y +M+ CW P+ R S ++ + L
Sbjct: 730 QLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 781
Score = 40.0 bits (92), Expect = 0.011
Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)
Query: 46 GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
G LLRC+VE G W+L T + SL + D C A
Sbjct: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267
Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
+DV E + N SF PAS +Q T V + +DG P
Sbjct: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310
Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
P+ +W +G+ L++ T + R+ LR P H +G Y+ A + FGQA
Sbjct: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370
Query: 210 CSS 212
+S
Sbjct: 371 SAS 373
Score = 30.8 bits (68), Expect = 6.9
Identities = 31/139 (22%), Positives = 53/139 (38%), Gaps = 21/139 (15%)
Query: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
L LAN+ ++ + TC A N G+ V + V+ P QL + C+
Sbjct: 249 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 301
Query: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
P P++ W N +++E S E ++G LR+N + Y
Sbjct: 302 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 361
Query: 482 MSSTPAGSIEAQARVQVLD 500
+++ P G A +D
Sbjct: 362 LAANPFGQASASIMAAFMD 380
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
precursor [Homo sapiens]
Length = 825
Score = 221 bits (563), Expect = 3e-57
Identities = 170/569 (29%), Positives = 268/569 (47%), Gaps = 61/569 (10%)
Query: 507 WVTDNAGTLHFARVTRDDAG-NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQ 565
W +A L VT +D G TCIA N G A V LTV P ++ +
Sbjct: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAEN-VVGMSNASVALTVYY------PPRVVSLEE 312
Query: 566 GHTALLQC---EAQGDPKPLIQWKGKDRILDPTKLGPRMHI-------FQNGSLVIHDVA 615
L C +G+P P + W + L +K+ +H+ G L+ +
Sbjct: 313 PELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKI---IHVEYYQEGEISEGCLLFNKPT 369
Query: 616 PEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEG-----PGSPPPYKMI------QT 664
++G YT IA N + + + +P PE ++ SP P + T
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDT 429
Query: 665 IGLSVG---AAVAYIIAVLGLMFYCKKRCKAKRLQKQP----EGEEPEMECLNGGPLQNG 717
G+S+ AA A ++ V+ + K ++K K P GEE L+
Sbjct: 430 FGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGIT 489
Query: 718 QPSA-EIQEEVALTSLGSGPAATNKRH-STSDKMHFPRSSLQPITT--------LGKSEF 767
PS+ + + + + P N ++ H P + +Q I LG+ F
Sbjct: 490 TPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAF 549
Query: 768 GEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCRE 827
G+VFLA+ L + LV VK+L+ + DF+RE E+ L H ++V+ G+C +
Sbjct: 550 GKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGD 609
Query: 828 AEPHYMVLEYVDLGDLKQFLR-------ISKSKDEKLKSQPLSTKQKVALCTQVALGMEH 880
+P MV EY+ GDL +FLR I + L Q + + +Q+A GM +
Sbjct: 610 GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVY 669
Query: 881 LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAIL 939
L++ FVH+DLA RNCLV A VK+ G+S+DVY+++YY +P+RWM PE+I+
Sbjct: 670 LASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM 729
Query: 940 EGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRL 999
F+T+SDVW+FGV++WE+FT+G+ P ++ EV+ + G+ L +P CP ++Y +
Sbjct: 730 YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRV-LERPRVCPKEVYDV 788
Query: 1000 MQRCWALSPKDRPSFSE---IASALGDST 1025
M CW P+ R + E I ALG +T
Sbjct: 789 MLGCWQREPQQRLNIKEIYKILHALGKAT 817
Score = 38.9 bits (89), Expect = 0.025
Identities = 48/187 (25%), Positives = 68/187 (36%), Gaps = 28/187 (14%)
Query: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389
G +TC G P P V W G++ + TH + H L L N+ D G
Sbjct: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
Query: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446
TC A N+ G V +TV P+ LEE + C+ + P PT+ W
Sbjct: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336
Query: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVL 499
N + E V G L N Y+ Y ++ P G+ Q +
Sbjct: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTAN-----QTI 391
Query: 500 DGSSLPE 506
+G L E
Sbjct: 392 NGHFLKE 398
Score = 34.3 bits (77), Expect = 0.62
Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)
Query: 527 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 585
N CI ++G Q + + ++ V TV +G A++ C G P P + W
Sbjct: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244
Query: 586 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 641
G I T L +H +L + +V ED+G TCIA N + + L V
Sbjct: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
Query: 642 VDKPVPEESEGP-------------GSPPP 658
P E P G+PPP
Sbjct: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331
Score = 33.9 bits (76), Expect = 0.81
Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)
Query: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
F ++I+ + ++ ++ V + A+ C S P P + W+ I + +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
L V A L+ N CI + G + A + + PRV +
Sbjct: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
Query: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
E C+ +G P P++ W H G L H YQ+G L+
Sbjct: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
Query: 383 ESDAGVYTCHAANLAGQRRQDVN 405
+ G YT A N G Q +N
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTIN 392
Score = 31.6 bits (70), Expect = 4.0
Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
+G A++ C V W++ G T + +++ V+ +D+G T
Sbjct: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
Query: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
C+A ++V G +NAS + + P V+ E ++ + +R G+P PT
Sbjct: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
Query: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
W +G PL + + H +E ++ L P H +G Y+ A + G A + N
Sbjct: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
[Homo sapiens]
Length = 709
Score = 221 bits (562), Expect = 4e-57
Identities = 144/500 (28%), Positives = 243/500 (48%), Gaps = 44/500 (8%)
Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 611
T K+E V +T +C A G+P P ++W K ++G Q+ SL++
Sbjct: 159 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 218
Query: 612 HDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVG 670
V P D G YTC+ N +I HT Y +D P + + P Y I + V
Sbjct: 219 ESVVPSDKGNYTCVVENEYGSINHT----YHLDVVAPGREKEITASPDYLEIAIYCIGVF 274
Query: 671 AAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVAL 729
++ V+ C+ K K+P+ +P + L Q + + ++
Sbjct: 275 LIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM 326
Query: 730 TSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLA 773
S T + ST+D K FPR L LG+ FG+V +A
Sbjct: 327 NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMA 386
Query: 774 KAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAE 829
+A G+++ + V V KD+ + D E+EM + H N++ LLG C +
Sbjct: 387 EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG 446
Query: 830 PHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLS 882
P Y+++EY G+L+++LR + ++ + ++ K V+ Q+A GME+L+
Sbjct: 447 PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA 506
Query: 883 NNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEG 941
+ + +H+DLAARN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ +
Sbjct: 507 SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR 566
Query: 942 DFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQ 1001
++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+
Sbjct: 567 VYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMR 625
Query: 1002 RCWALSPKDRPSFSEIASAL 1021
CW P RP+F ++ L
Sbjct: 626 DCWHAVPSQRPTFKQLVEDL 645
Score = 38.5 bits (88), Expect = 0.033
Identities = 43/202 (21%), Positives = 66/202 (32%), Gaps = 36/202 (17%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFG 207
+ P G Y+C + +G
Sbjct: 217 IMESVVPSDKGNYTCVVENEYG 238
Score = 34.7 bits (78), Expect = 0.48
Identities = 58/251 (23%), Positives = 91/251 (36%), Gaps = 67/251 (26%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
SL++ V P + G Y C+ + + G + T HL V
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHL-----------DVVA 250
Query: 335 AGSEERVTCLP 345
G E+ +T P
Sbjct: 251 PGREKEITASP 261
Score = 32.3 bits (72), Expect = 2.4
Identities = 45/216 (20%), Positives = 75/216 (34%), Gaps = 36/216 (16%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
+G+Y C A+ + V S E+ G D +++ + +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAIS------SGDDEDDTDGAEDFVSENSNNKRAPY 155
Query: 446 YRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
+ N + + R+++V + +RC PAG + +G
Sbjct: 156 WTNTEKMEK------------RLHAVPAANTVKFRC----PAGGNPMPTMRWLKNGKEFK 199
Query: 506 E-------WVTDNAGTLHFARVTRDDAGNYTCIASN 534
+ V + +L V D GNYTC+ N
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN 235
>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
[Homo sapiens]
Length = 704
Score = 220 bits (561), Expect = 5e-57
Identities = 162/549 (29%), Positives = 260/549 (47%), Gaps = 61/549 (11%)
Query: 520 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 573
V D GNYTC+ N G I L V + + +TV G + C
Sbjct: 106 VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 163
Query: 574 EAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDS 619
+ D +P IQW K + +K GP + + + L I +V ED+
Sbjct: 164 KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA 222
Query: 620 GRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAV 679
G YTC+AGNS I A L V+ P P + + P Y I + V ++ V
Sbjct: 223 GEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTV 280
Query: 680 LGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEE-------VALTS 731
+ C+ K K+P+ +P + L Q SAE V +T+
Sbjct: 281 I--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITT 332
Query: 732 LGSGPAATNKRHSTSD-------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE 784
S A T S+ K FPR L LG+ FG+V +A+A G+++ +
Sbjct: 333 RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 392
Query: 785 TLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDL 840
V V KD+ + D E+EM + H N++ LLG C + P Y+++EY
Sbjct: 393 EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 452
Query: 841 GDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAA 893
G+L+++LR + ++ + ++ K V+ Q+A GME+L++ + +H+DLAA
Sbjct: 453 GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 512
Query: 894 RNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAF 952
RN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ + ++ +SDVW+F
Sbjct: 513 RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 572
Query: 953 GVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRP 1012
GVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P RP
Sbjct: 573 GVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRP 631
Query: 1013 SFSEIASAL 1021
+F ++ L
Sbjct: 632 TFKQLVEDL 640
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 611
T K+E V +T +C A G+P P ++W K ++G Q+ SL++
Sbjct: 44 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 103
Query: 612 HDVAPEDSGRYTCIAGNSC-NIKHT 635
V P D G YTC+ N +I HT
Sbjct: 104 ESVVPSDKGNYTCVVENEYGSINHT 128
Score = 43.9 bits (102), Expect = 8e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 60 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 119
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 120 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 176
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c
precursor [Homo sapiens]
Length = 822
Score = 220 bits (560), Expect = 6e-57
Identities = 167/571 (29%), Positives = 266/571 (46%), Gaps = 73/571 (12%)
Query: 513 GTLHFARVTRDDAGNY-TCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTA 569
G+L ++ DD+G +C+A N G+ + V LTV A ITF P H
Sbjct: 248 GSLRITNISSDDSGKQISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHW 301
Query: 570 LLQCEAQGDPKPLIQWKGKDRILDP-----TKLGPRMHIFQNGSLVIHDVAPEDSGRYTC 624
+ +G+PKP +QW IL+ TK+ H +G L + + ++G YT
Sbjct: 302 CIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTL 361
Query: 625 IAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPP-YKMIQTIGLSVGA------------ 671
IA N + + + P ++ P P Y+ T +G
Sbjct: 362 IAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTD 421
Query: 672 -------------AVAYIIAVLG-----LMFYCKKRCKAKRLQKQP--------EGEEPE 705
AV I +V+G ++F K +K K P + P
Sbjct: 422 VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPL 481
Query: 706 MECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHS--TSDKM-------HFPRSSL 756
NG N S+E + + + P N ++ T+ ++ H R ++
Sbjct: 482 HHISNGS---NTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNI 538
Query: 757 QPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHA 816
LG+ FG+VFLA+ L + LV VK+L+ + + DF RE E+ L H
Sbjct: 539 VLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHE 598
Query: 817 NVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ-----PLSTKQKVALC 871
++V+ G+C E +P MV EY+ GDL +FLR + D L ++ L+ Q + +
Sbjct: 599 HIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAVLMAEGNPPTELTQSQMLHIA 657
Query: 872 TQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPL 930
Q+A GM +L++ FVH+DLA RNCLV VK+ G+S+DVY+++YY +P+
Sbjct: 658 QQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 717
Query: 931 RWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE 990
RWM PE+I+ F+T+SDVW+ GV++WE+FT+G+ P +++EV+ + G+ L +P
Sbjct: 718 RWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV-LQRPR 776
Query: 991 GCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
CP ++Y LM CW P R + I + L
Sbjct: 777 TCPQEVYELMLGCWQREPHMRKNIKGIHTLL 807
Score = 41.2 bits (95), Expect = 0.005
Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 8/110 (7%)
Query: 348 GLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVY-TCHAANLAGQRRQDVNI 406
G P P+++W+ + L + NI+ D+G +C A NL G+ + VN+
Sbjct: 222 GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNL 281
Query: 407 TVATVPS--WLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISE 454
TV P+ +L+ P + + PKP + W+ N +++E
Sbjct: 282 TVHFAPTITFLESPTSDH-----HWCIPFTVKGNPKPALQWFYNGAILNE 326
Score = 37.4 bits (85), Expect = 0.073
Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
+G+ L C V ++YW + + SL + CVA
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268
Query: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
+++ GE+ S N + + P + L+ P S+ + + G+P+P QW
Sbjct: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317
Query: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
F +G L++ + H + E + L+ P H +G Y+ A + +G+
Sbjct: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
Score = 33.9 bits (76), Expect = 0.81
Identities = 28/95 (29%), Positives = 40/95 (42%), Gaps = 5/95 (5%)
Query: 562 TVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGR 621
TV +G + L C GDP P + W + L + H GSL I +++ +DSG+
Sbjct: 207 TVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSH--TQGSLRITNISSDDSGK 262
Query: 622 -YTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGS 655
+C+A N L V P E P S
Sbjct: 263 QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS 297
Score = 33.5 bits (75), Expect = 1.1
Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)
Query: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
A ++ +TL C + G P P W D L N T S + +L + +
Sbjct: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259
Query: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
SG SC A + G+ S N T+ FA + + + F P
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312
Query: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
P+LQW + I N S+ H+ T + +G L L N G Y I + + G
Sbjct: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368
>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
[Homo sapiens]
Length = 808
Score = 219 bits (559), Expect = 8e-57
Identities = 201/753 (26%), Positives = 311/753 (41%), Gaps = 109/753 (14%)
Query: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
E VF +G ++C PP G P W G L RV L + N + D+G
Sbjct: 47 EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106
Query: 389 YTCHAANLAGQRRQDVNITVATVPS------WLKKPQDSQLEEGKPGY-----LDCLTQA 437
Y+C L + ++ V PS + +D+ ++ G P + +D A
Sbjct: 107 YSCRQ-RLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLA 165
Query: 438 TPKPTVVWYRNQMLISEDSRFEVFKNGTL-----RINSVEVYDGTWYRCMSSTPAGSIEA 492
P V +R + KNG RI +++ W M S
Sbjct: 166 VPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMES-------- 217
Query: 493 QARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFI 552
V D GNYTC+ N G IR L V
Sbjct: 218 ---------------------------VVPSDRGNYTCVVEN-KFGSIRQTYTLDVLERS 249
Query: 553 TFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGP-------- 599
+ P T G C+ D +P IQW K ++ +K+GP
Sbjct: 250 PHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL-KHVEVNGSKVGPDGTPYVTV 308
Query: 600 -----RMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEES--EG 652
+ + L + +V+ D G Y C A N + L V EE E
Sbjct: 309 LKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEA 368
Query: 653 PGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKR---------LQKQPEGEE 703
+ Y I LS G I V+ + C+ R K+ + + P +
Sbjct: 369 DEAGSVYAGI----LSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQ 424
Query: 704 PEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRH---STSDKMHFPRSSLQPIT 760
+E + + + P I A S G GP N K R+ L
Sbjct: 425 VSLE--SNASMSSNTPLVRI----ARLSSGEGPTLANVSELELPADPKWELSRARLTLGK 478
Query: 761 TLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HA 816
LG+ FG+V +A+A G+++ A V V KD+ D E+EM + H
Sbjct: 479 PLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHK 538
Query: 817 NVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDE-KLKSQPLSTKQKVA 869
N++ LLG C + P Y+++EY G+L++FLR + S D K + L+ K V+
Sbjct: 539 NIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVS 598
Query: 870 LCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWV 928
QVA GME+L++ + +H+DLAARN LV+ +K++ GL++DV+N +YY +
Sbjct: 599 CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRL 658
Query: 929 PLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ 988
P++WM+PEA+ + ++ +SDVW+FGVL+WE+FT G P+ G +E+ L+ G R+ +
Sbjct: 659 PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDK 717
Query: 989 PEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
P C LY +M+ CW +P RP+F ++ L
Sbjct: 718 PANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 750
Score = 54.3 bits (129), Expect = 6e-07
Identities = 68/312 (21%), Positives = 109/312 (34%), Gaps = 62/312 (19%)
Query: 37 QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
+P Q+ L G L C GP+ W+ DG + +ER L
Sbjct: 42 EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101
Query: 93 LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
+DSG + C R DD GE+ ++ G
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154
Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
P + + V RC G+P P+ W ++G + + H + ++
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211
Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
+L + P G Y+C + FG Q +TL + + S R +L P +
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSR-----PPHLR------RATVFANGSLLLT 289
+ FHC+ + P +QWL E N S+ P++ +V A+ L L
Sbjct: 270 DVEFHCKVYSDAQPHIQWLKHVE---VNGSKVGPDGTPYVTVLKSWISESVEADVRLRLA 326
Query: 290 QVRPRNAGIYRC 301
V R+ G Y C
Sbjct: 327 NVSERDGGEYLC 338
Score = 38.5 bits (88), Expect = 0.033
Identities = 66/293 (22%), Positives = 97/293 (33%), Gaps = 61/293 (20%)
Query: 154 GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQ 213
G P W +DGT L + V + L + A E SG YSC C
Sbjct: 66 GGPMGPTVWVKDGTGLVPSER---VLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC--- 119
Query: 214 NFTLSIAD-------------------ESFARVVLAPQDV-----VVARYEEAMFHCQFS 249
+F++ + D ++ A P+ + V F C +
Sbjct: 120 HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAA 179
Query: 250 AQPPPSLQWLFED-ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
P PS+ WL E +R LR SL++ V P + G Y C+ + + G
Sbjct: 180 GNPTPSISWLKNGREFRGEHRIGGIKLRHQ----QWSLVMESVVPSDRGNYTCVVENKFG 235
Query: 309 PPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA- 359
+ T L +E P L + GS+ C W +H
Sbjct: 236 S---IRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVE 292
Query: 360 --GVRLPTHGRVY------------QKGHELVLANIAESDAGVYTCHAANLAG 398
G ++ G Y + L LAN++E D G Y C A N G
Sbjct: 293 VNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIG 345
>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
[Homo sapiens]
Length = 706
Score = 219 bits (558), Expect = 1e-56
Identities = 158/551 (28%), Positives = 259/551 (47%), Gaps = 63/551 (11%)
Query: 520 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 573
V D GNYTC+ N G I L V + + +TV G + C
Sbjct: 106 VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 163
Query: 574 EAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDS 619
+ D +P IQW K + +K GP + + + L I +V ED+
Sbjct: 164 KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA 222
Query: 620 GRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAV 679
G YTC+AGNS I A L V+ P P + + P Y I + V ++ V
Sbjct: 223 GEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTV 280
Query: 680 LGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAA 738
+ C+ K K+P+ +P + L Q + + ++ S
Sbjct: 281 I--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 332
Query: 739 TNKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGV 782
T + ST+D K FPR L LG+ FG+V +A+A G+++
Sbjct: 333 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 392
Query: 783 AETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYV 838
+ V V KD+ + D E+EM + H N++ LLG C + P Y+++EY
Sbjct: 393 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 452
Query: 839 DLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDL 891
G+L+++LR + ++ + ++ K V+ Q+A GME+L++ + +H+DL
Sbjct: 453 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 512
Query: 892 AARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVW 950
AARN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ + ++ +SDVW
Sbjct: 513 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 572
Query: 951 AFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKD 1010
+FGVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P
Sbjct: 573 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQ 631
Query: 1011 RPSFSEIASAL 1021
RP+F ++ L
Sbjct: 632 RPTFKQLVEDL 642
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 611
T K+E V +T +C A G+P P ++W K ++G Q+ SL++
Sbjct: 44 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 103
Query: 612 HDVAPEDSGRYTCIAGNSC-NIKHT 635
V P D G YTC+ N +I HT
Sbjct: 104 ESVVPSDKGNYTCVVENEYGSINHT 128
Score = 43.9 bits (102), Expect = 8e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 60 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 119
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 120 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 176
>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
[Homo sapiens]
Length = 707
Score = 219 bits (558), Expect = 1e-56
Identities = 158/551 (28%), Positives = 259/551 (47%), Gaps = 63/551 (11%)
Query: 520 VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 573
V D GNYTC+ N G I L V + + +TV G + C
Sbjct: 132 VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 189
Query: 574 EAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDS 619
+ D +P IQW K + +K GP + + + L I +V ED+
Sbjct: 190 KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA 248
Query: 620 GRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAV 679
G YTC+AGNS I A L V+ P P + + P Y I + V ++ V
Sbjct: 249 GEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTV 306
Query: 680 LGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAA 738
+ C+ K K+P+ +P + L Q + + ++ S
Sbjct: 307 I--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 358
Query: 739 TNKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGV 782
T + ST+D K FPR L LG+ FG+V +A+A G+++
Sbjct: 359 TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 418
Query: 783 AETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYV 838
+ V V KD+ + D E+EM + H N++ LLG C + P Y+++EY
Sbjct: 419 PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 478
Query: 839 DLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDL 891
G+L+++LR + ++ + ++ K V+ Q+A GME+L++ + +H+DL
Sbjct: 479 SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 538
Query: 892 AARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVW 950
AARN LV+ +K++ GL++D+ N +YY +P++WM+PEA+ + ++ +SDVW
Sbjct: 539 AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 598
Query: 951 AFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKD 1010
+FGVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +M+ CW P
Sbjct: 599 SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQ 657
Query: 1011 RPSFSEIASAL 1021
RP+F ++ L
Sbjct: 658 RPTFKQLVEDL 668
Score = 45.8 bits (107), Expect = 2e-04
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)
Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 611
T K+E V +T +C A G+P P ++W K ++G Q+ SL++
Sbjct: 70 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 129
Query: 612 HDVAPEDSGRYTCIAGNSC-NIKHT 635
V P D G YTC+ N +I HT
Sbjct: 130 ESVVPSDKGNYTCVVENEYGSINHT 154
Score = 43.9 bits (102), Expect = 8e-04
Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W ++G + V ++ +L + P G Y+C
Sbjct: 86 VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 145
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+ +G + + L + + S R +L P + + F C+ + P +QW+
Sbjct: 146 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 202
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 217 bits (553), Expect = 4e-56
Identities = 132/398 (33%), Positives = 214/398 (53%), Gaps = 40/398 (10%)
Query: 642 VDKP-VPEESEGPGS-PPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQP 699
VD P +P S S P Y M T+ +S+ ++ A + + YC C+ ++ K
Sbjct: 473 VDIPNLPSSSSSSFSVSPTYSM--TVIISIMSSFAIFVLLTITTLYC---CRRRKQWKNK 527
Query: 700 EGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM---HFPRSSL 756
+ E + + E+ L L P + K+ +PR+++
Sbjct: 528 KRESAAVTLTT------------LPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNI 575
Query: 757 QPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNH 815
+ + +G+ FG VF A+A GL T+V VK L+ + Q DF+RE + + ++
Sbjct: 576 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 635
Query: 816 ANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKS--------KDEKLKSQ------- 860
N+V+LLG+C +P ++ EY+ GDL +FLR D +++Q
Sbjct: 636 PNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPP 695
Query: 861 PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 920
PLS +++ + QVA GM +LS +FVH+DLA RNCLV VK++ GLS+++Y+++Y
Sbjct: 696 PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADY 755
Query: 921 YHFRQ-AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADL 979
Y + +P+RWM PE+I ++T+SDVWA+GV++WE+F++G P+ G A +EV+ +
Sbjct: 756 YKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYV 815
Query: 980 QAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1017
+ G L PE CP +LY LM+ CW+ P DRPSF+ I
Sbjct: 816 RDGNI-LSCPENCPVELYNLMRLCWSKLPADRPSFTSI 852
Score = 81.6 bits (200), Expect = 3e-15
Identities = 73/306 (23%), Positives = 111/306 (36%), Gaps = 83/306 (27%)
Query: 350 PEPSVWWEHAGVRLP---THGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVN- 405
P+P + W + + T + + G L + ++ +SD G+Y C A N G +
Sbjct: 55 PQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGA 114
Query: 406 ITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGT 465
+ V P + P + ++ EG L C T PKP+V W + + E+SR V ++G+
Sbjct: 115 LQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGS 174
Query: 466 LRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDA 525
LRI++V+ D YRC++ G+ ++
Sbjct: 175 LRIHNVQKEDAGQYRCVAKNSLGTAYSKV------------------------------- 203
Query: 526 GNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 585
V+L V VF PE V G L C A G P P I W
Sbjct: 204 ------------------VKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITW 245
Query: 586 --------------KGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCN 631
KDR++D R+ +F G YTCIA N
Sbjct: 246 IENGNAVSSGSIQESVKDRVID-----SRLQLFIT-----------KPGLYTCIATNKHG 289
Query: 632 IKHTEA 637
K + A
Sbjct: 290 EKFSTA 295
Score = 77.8 bits (190), Expect = 5e-14
Identities = 65/300 (21%), Positives = 125/300 (41%), Gaps = 21/300 (7%)
Query: 130 VLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRP 189
V+ P + + T C ++ +P+P W R+ + + +++ + LT+
Sbjct: 29 VITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILS 88
Query: 190 AGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFS 249
G+Y C A++ G A S ++ + ++ P +V + +A+ C
Sbjct: 89 VEDSDDGIYCCTANNGVGGAVESCG---ALQVKMKPKITRPPINVKIIEGLKAVLPCTTM 145
Query: 250 AQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGP 309
P PS+ W+ + ++P+ S R V +GSL + V+ +AG YRC+ + G
Sbjct: 146 GNPKPSVSWI-KGDSPLRENS------RIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGT 198
Query: 310 PIILEATLHL---AEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTH 366
L + A I P E T GS + C G+P P++ W G +
Sbjct: 199 AYSKVVKLEVEVFARILRAP--ESHNVTFGSFVTLHC-TATGIPVPTITWIENG-NAVSS 254
Query: 367 GRVYQKGHELVLANIAE---SDAGVYTCHAANLAGQRRQDVNITVA-TVPSWLKKPQDSQ 422
G + + + V+ + + + G+YTC A N G++ ++ W K +D++
Sbjct: 255 GSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNK 314
Score = 59.3 bits (142), Expect = 2e-08
Identities = 75/300 (25%), Positives = 112/300 (37%), Gaps = 37/300 (12%)
Query: 225 ARVVLAPQDVVVARYEE-AMFHCQFSAQPPPSLQW--------LFEDETPITNRSRPPHL 275
A V+ P + V A EE A F C + P P + W LF+
Sbjct: 27 APVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDT------------- 73
Query: 276 RRATVFANGSLL-LTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-LFEPRVF 333
R ++ NG LL + V + GIY C G + L +++ P + P +
Sbjct: 74 -RYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGAL---QVKMKPKITRPPIN 129
Query: 334 TAGSEERVTCLP--PKGLPEPSVWWEHAGVRLPTHGRV-YQKGHELVLANIAESDAGVYT 390
E LP G P+PSV W L + R+ + L + N+ + DAG Y
Sbjct: 130 VKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYR 189
Query: 391 CHAANLAGQRRQDV-NITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQ 449
C A N G V + V L+ P+ + G L C P PT+ W N
Sbjct: 190 CVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENG 249
Query: 450 MLISEDSRFEVFKNGTL--RINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLPEW 507
+S S E K+ + R+ G Y C+++ G + A+ S+ EW
Sbjct: 250 NAVSSGSIQESVKDRVIDSRLQLFITKPGL-YTCIATNKHGEKFSTAKAAAT--ISIAEW 306
Score = 57.4 bits (137), Expect = 7e-08
Identities = 49/193 (25%), Positives = 87/193 (45%), Gaps = 15/193 (7%)
Query: 36 KQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTER-RFAQGSSLSFAAVDRLQ 94
+ P + ++G +A+L C V W+ +P+++ R + SL V + +
Sbjct: 125 RPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQK-E 183
Query: 95 DSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDG 154
D+G ++CVA++ + ++ +E +L+ P S + + VTL C G
Sbjct: 184 DAGQYRCVAKNSLGTAYSKVVKLE-----VEVFARILRAPESH-NVTFGSFVTLHCTATG 237
Query: 155 HPRPTYQWFRDGTPLSDGQSNHTVSSK--ERNLTLRPAGPEHSGLYSCCAHSAFGQACSS 212
P PT W +G +S G +V + + L L P GLY+C A + G+ S+
Sbjct: 238 IPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHGEKFST 294
Query: 213 QN--FTLSIADES 223
T+SIA+ S
Sbjct: 295 AKAAATISIAEWS 307
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 217 bits (552), Expect = 5e-56
Identities = 210/756 (27%), Positives = 330/756 (43%), Gaps = 110/756 (14%)
Query: 308 GPPII-LEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK----GLPEPSVWWEHAGVR 362
GPP++ LEA+ E+E P P + E V P G E W G R
Sbjct: 16 GPPVLSLEAS---EEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSR 72
Query: 363 LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQ 422
L GRV L +A+ DAG Y C A G N+T+ T S D
Sbjct: 73 LAPAGRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTLITGDSLTSSNDD-- 127
Query: 423 LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCM 482
E+ K + P+ W Q + ++++V + +RC
Sbjct: 128 -EDPKSHRDPSNRHSYPQQAPYWTHPQRMEK-------------KLHAVPAGNTVKFRCP 173
Query: 483 SS-TPAGSIEAQARVQVLDGSSLPEWVT--DNAGTLHFARVTRDDAGNYTCIASNGPQGQ 539
++ P +I Q G + + +L V D G YTC+ N G
Sbjct: 174 AAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAV-GS 232
Query: 540 IRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDP 594
IR + L V + P TT G L C+ D +P IQW K +++
Sbjct: 233 IRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL-KHIVING 291
Query: 595 TKLG----PRMHIFQNGS--------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 642
+ G P + + + L + +V+ ED+G YTC+AGNS + + A L V+
Sbjct: 292 SSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL 351
Query: 643 DKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGE 702
G G P C A R +
Sbjct: 352 P--------GTGRIPHLT-------------------------CDSLTPAGRTKS----- 373
Query: 703 EPEME-CLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM----HFPRSSLQ 757
P ++ L G +G+ S+ + V L+S SGPA S + FPR L
Sbjct: 374 -PTLQFSLESG--SSGKSSSSLVRGVRLSS--SGPALLAGLVSLDLPLDPLWEFPRDRLV 428
Query: 758 PITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN 814
LG+ FG+V A+A G++ + + V VK L+ + L D E+E+ +
Sbjct: 429 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 488
Query: 815 -HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDEKLKSQ-PLSTKQ 866
H N++ LLG+C + P Y+++E G+L++FLR + S D S+ PLS
Sbjct: 489 RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 548
Query: 867 KVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQ 925
V+ QVA GM++L + + +H+DLAARN LV+ +K++ GL++ V++ +YY
Sbjct: 549 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 608
Query: 926 AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKAR 985
+P++WM+PEA+ + ++ +SDVW+FG+L+WE+FT G P+ G +E+ + L+ G R
Sbjct: 609 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH-R 667
Query: 986 LPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
+ +P CP +LY LM+ CW +P RP+F ++ AL
Sbjct: 668 MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 703
Score = 43.9 bits (102), Expect = 8e-04
Identities = 28/119 (23%), Positives = 47/119 (39%), Gaps = 7/119 (5%)
Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGPEHSGLYSCCAH 203
V RC G+P PT +W +DG + + + +L + P G Y+C
Sbjct: 168 VKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVE 227
Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
+A G N+ L + + S R +L P + + C+ + P +QWL
Sbjct: 228 NAVGSI--RYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL 284
>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform a
precursor [Homo sapiens]
Length = 839
Score = 216 bits (550), Expect = 9e-56
Identities = 170/583 (29%), Positives = 268/583 (45%), Gaps = 75/583 (12%)
Query: 507 WVTDNAGTLHFARVTRDDAG-NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQ 565
W +A L VT +D G TCIA N G A V LTV P ++ +
Sbjct: 260 WTNVHAINLTLVNVTSEDNGFTLTCIAEN-VVGMSNASVALTVYY------PPRVVSLEE 312
Query: 566 GHTALLQC---EAQGDPKPLIQWKGKDRILDPTKLGPRMHI-------FQNGSLVIHDVA 615
L C +G+P P + W + L +K+ +H+ G L+ +
Sbjct: 313 PELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKI---IHVEYYQEGEISEGCLLFNKPT 369
Query: 616 PEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEG-----PGSPPPYKMI------QT 664
++G YT IA N + + + +P PE ++ SP P + T
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDT 429
Query: 665 IGLSVG---AAVAYIIAVLGLMFYCKKRCKAKRLQKQP----EGEEPEMECLNGGPLQNG 717
G+S+ AA A ++ V+ + K ++K K P GEE L+
Sbjct: 430 FGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGIT 489
Query: 718 QPSA-EIQEEVALTSLGSGPAATNKRH-STSDKMHFPRSSLQPITT--------LGKSEF 767
PS+ + + + + P N ++ H P + +Q I LG+ F
Sbjct: 490 TPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAF 549
Query: 768 GEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCRE 827
G+VFLA+ L + LV VK+L+ + DF+RE E+ L H ++V+ G+C +
Sbjct: 550 GKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGD 609
Query: 828 AEPHYMVLEYVDLGDLKQFLR-------ISKSKDEKLKSQPLSTKQKVALCTQVALGMEH 880
+P MV EY+ GDL +FLR I + L Q + + +Q+A GM +
Sbjct: 610 GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVY 669
Query: 881 LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF---------------RQ 925
L++ FVH+DLA RNCLV A VK+ G+S+DVY+++YY
Sbjct: 670 LASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGH 729
Query: 926 AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKAR 985
+P+RWM PE+I+ F+T+SDVW+FGV++WE+FT+G+ P ++ EV+ + G+
Sbjct: 730 TMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRV- 788
Query: 986 LPQPEGCPSKLYRLMQRCWALSPKDRPSFSE---IASALGDST 1025
L +P CP ++Y +M CW P+ R + E I ALG +T
Sbjct: 789 LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKAT 831
Score = 38.9 bits (89), Expect = 0.025
Identities = 48/187 (25%), Positives = 68/187 (36%), Gaps = 28/187 (14%)
Query: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389
G +TC G P P V W G++ + TH + H L L N+ D G
Sbjct: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
Query: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446
TC A N+ G V +TV P+ LEE + C+ + P PT+ W
Sbjct: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336
Query: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVL 499
N + E V G L N Y+ Y ++ P G+ Q +
Sbjct: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTAN-----QTI 391
Query: 500 DGSSLPE 506
+G L E
Sbjct: 392 NGHFLKE 398
Score = 34.3 bits (77), Expect = 0.62
Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)
Query: 527 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 585
N CI ++G Q + + ++ V TV +G A++ C G P P + W
Sbjct: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244
Query: 586 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 641
G I T L +H +L + +V ED+G TCIA N + + L V
Sbjct: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301
Query: 642 VDKPVPEESEGP-------------GSPPP 658
P E P G+PPP
Sbjct: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331
Score = 33.9 bits (76), Expect = 0.81
Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)
Query: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
F ++I+ + ++ ++ V + A+ C S P P + W+ I + +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
L V A L+ N CI + G + A + + PRV +
Sbjct: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309
Query: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
E C+ +G P P++ W H G L H YQ+G L+
Sbjct: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369
Query: 383 ESDAGVYTCHAANLAGQRRQDVN 405
+ G YT A N G Q +N
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTIN 392
Score = 31.6 bits (70), Expect = 4.0
Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
+G A++ C V W++ G T + +++ V+ +D+G T
Sbjct: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282
Query: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
C+A ++V G +NAS + + P V+ E ++ + +R G+P PT
Sbjct: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332
Query: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
W +G PL + + H +E ++ L P H +G Y+ A + G A + N
Sbjct: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392
>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
[Homo sapiens]
Length = 769
Score = 216 bits (549), Expect = 1e-55
Identities = 191/751 (25%), Positives = 319/751 (42%), Gaps = 96/751 (12%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
+G+Y C A+ + V S E+ G D +++ + +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAIS------SGDDEDDTDGAEDFVSENSNNKRAPY 155
Query: 446 YRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
+ N + + R+++V + +RC PAG + +G
Sbjct: 156 WTNTEKMEK------------RLHAVPAANTVKFRC----PAGGNPMPTMRWLKNGKEFK 199
Query: 506 EW-------VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FI 552
+ V + +L V D GNYTC+ N G I L V +
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPIL 258
Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR--------MHIF 604
+ +TV G + C+ D +P IQW K + +K GP H
Sbjct: 259 QAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKHSG 316
Query: 605 QNGS----LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKP-VPEESEGPGSPPPY 659
N S L + +V D+G Y C N + A L V+ K P + + P Y
Sbjct: 317 INSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDY 376
Query: 660 KMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQ 718
I + V ++ V+ C+ K K+P+ +P + L Q
Sbjct: 377 LEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQ 428
Query: 719 PSAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITTL 762
+ + ++ S T + ST+D K FPR L L
Sbjct: 429 VTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL 488
Query: 763 GKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANV 818
G+ FG+V +A+A G+++ + V V KD+ + D E+EM + H N+
Sbjct: 489 GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI 548
Query: 819 VRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALC 871
+ LLG C + P Y+++EY G+L+++LR + ++ + ++ K V+
Sbjct: 549 INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCT 608
Query: 872 TQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPL 930
Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY +P+
Sbjct: 609 YQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 668
Query: 931 RWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE 990
+WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G R+ +P
Sbjct: 669 KWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPA 727
Query: 991 GCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
C ++LY +M+ CW P RP+F ++ L
Sbjct: 728 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758
Score = 51.6 bits (122), Expect = 4e-06
Identities = 80/337 (23%), Positives = 120/337 (35%), Gaps = 80/337 (23%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261
Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQK---------- 372
L G + C +P + W E G + G Y K
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSS 320
Query: 373 -GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
L L N+ E+DAG Y C +N GQ Q +TV
Sbjct: 321 NAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTV 357
Score = 47.0 bits (110), Expect = 9e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
[Homo sapiens]
Length = 822
Score = 216 bits (549), Expect = 1e-55
Identities = 191/751 (25%), Positives = 319/751 (42%), Gaps = 96/751 (12%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
+G+Y C A+ + V S E+ G D +++ + +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAIS------SGDDEDDTDGAEDFVSENSNNKRAPY 155
Query: 446 YRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
+ N + + R+++V + +RC PAG + +G
Sbjct: 156 WTNTEKMEK------------RLHAVPAANTVKFRC----PAGGNPMPTMRWLKNGKEFK 199
Query: 506 EW-------VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FI 552
+ V + +L V D GNYTC+ N G I L V +
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPIL 258
Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR--------MHIF 604
+ +TV G + C+ D +P IQW K + +K GP H
Sbjct: 259 QAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKHSG 316
Query: 605 QNGS----LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKP-VPEESEGPGSPPPY 659
N S L + +V D+G Y C N + A L V+ K P + + P Y
Sbjct: 317 INSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDY 376
Query: 660 KMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQ 718
I + V ++ V+ C+ K K+P+ +P + L Q
Sbjct: 377 LEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQ 428
Query: 719 PSAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITTL 762
+ + ++ S T + ST+D K FPR L L
Sbjct: 429 VTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL 488
Query: 763 GKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANV 818
G+ FG+V +A+A G+++ + V V KD+ + D E+EM + H N+
Sbjct: 489 GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI 548
Query: 819 VRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALC 871
+ LLG C + P Y+++EY G+L+++LR + ++ + ++ K V+
Sbjct: 549 INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCT 608
Query: 872 TQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPL 930
Q+A GME+L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY +P+
Sbjct: 609 YQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 668
Query: 931 RWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE 990
+WM+PEA+ + ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G R+ +P
Sbjct: 669 KWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPA 727
Query: 991 GCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
C ++LY +M+ CW P RP+F ++ L
Sbjct: 728 NCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758
Score = 51.6 bits (122), Expect = 4e-06
Identities = 80/337 (23%), Positives = 120/337 (35%), Gaps = 80/337 (23%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261
Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQK---------- 372
L G + C +P + W E G + G Y K
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSS 320
Query: 373 -GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
L L N+ E+DAG Y C +N GQ Q +TV
Sbjct: 321 NAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTV 357
Score = 47.0 bits (110), Expect = 9e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a
precursor [Homo sapiens]
Length = 838
Score = 214 bits (545), Expect = 3e-55
Identities = 167/584 (28%), Positives = 267/584 (45%), Gaps = 83/584 (14%)
Query: 513 GTLHFARVTRDDAGNY-TCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTA 569
G+L ++ DD+G +C+A N G+ + V LTV A ITF P H
Sbjct: 248 GSLRITNISSDDSGKQISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHW 301
Query: 570 LLQCEAQGDPKPLIQWKGKDRILDP-----TKLGPRMHIFQNGSLVIHDVAPEDSGRYTC 624
+ +G+PKP +QW IL+ TK+ H +G L + + ++G YT
Sbjct: 302 CIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTL 361
Query: 625 IAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPP-YKMIQTIGLSVGA------------ 671
IA N + + + P ++ P P Y+ T +G
Sbjct: 362 IAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTD 421
Query: 672 -------------AVAYIIAVLG----LMFYCKKRCKAKRLQ------------KQPEGE 702
AV I +V+G +M + K + + K +G
Sbjct: 422 VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGV 481
Query: 703 EPEMECLN----GGPLQ------NGQPSAEIQEEVALTSLGSGPAATNKRHS--TSDKM- 749
P N PL N S+E + + + P N ++ T+ ++
Sbjct: 482 GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLK 541
Query: 750 ------HFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDF 803
H R ++ LG+ FG+VFLA+ L + LV VK+L+ + + DF
Sbjct: 542 PDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDF 601
Query: 804 RRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ--- 860
RE E+ L H ++V+ G+C E +P MV EY+ GDL +FLR + D L ++
Sbjct: 602 HREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAVLMAEGNP 660
Query: 861 --PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNS 918
L+ Q + + Q+A GM +L++ FVH+DLA RNCLV VK+ G+S+DVY++
Sbjct: 661 PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 720
Query: 919 EYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLA 977
+YY +P+RWM PE+I+ F+T+SDVW+ GV++WE+FT+G+ P +++EV+
Sbjct: 721 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 780
Query: 978 DLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
+ G+ L +P CP ++Y LM CW P R + I + L
Sbjct: 781 CITQGRV-LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 823
Score = 41.2 bits (95), Expect = 0.005
Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 8/110 (7%)
Query: 348 GLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVY-TCHAANLAGQRRQDVNI 406
G P P+++W+ + L + NI+ D+G +C A NL G+ + VN+
Sbjct: 222 GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNL 281
Query: 407 TVATVPS--WLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISE 454
TV P+ +L+ P + + PKP + W+ N +++E
Sbjct: 282 TVHFAPTITFLESPTSDH-----HWCIPFTVKGNPKPALQWFYNGAILNE 326
Score = 37.4 bits (85), Expect = 0.073
Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)
Query: 45 QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
+G+ L C V ++YW + + SL + CVA
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268
Query: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
+++ GE+ S N + + P + L+ P S+ + + G+P+P QW
Sbjct: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317
Query: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
F +G L++ + H + E + L+ P H +G Y+ A + +G+
Sbjct: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369
Score = 33.9 bits (76), Expect = 0.81
Identities = 28/95 (29%), Positives = 40/95 (42%), Gaps = 5/95 (5%)
Query: 562 TVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGR 621
TV +G + L C GDP P + W + L + H GSL I +++ +DSG+
Sbjct: 207 TVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSH--TQGSLRITNISSDDSGK 262
Query: 622 -YTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGS 655
+C+A N L V P E P S
Sbjct: 263 QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS 297
Score = 33.5 bits (75), Expect = 1.1
Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)
Query: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
A ++ +TL C + G P P W D L N T S + +L + +
Sbjct: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259
Query: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
SG SC A + G+ S N T+ FA + + + F P
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312
Query: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
P+LQW + I N S+ H+ T + +G L L N G Y I + + G
Sbjct: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368
>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
[Homo sapiens]
Length = 705
Score = 212 bits (540), Expect = 1e-54
Identities = 148/502 (29%), Positives = 247/502 (49%), Gaps = 52/502 (10%)
Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 611
T K+E V +T +C A G+P P ++W K ++G Q+ SL++
Sbjct: 159 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 218
Query: 612 HDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVG 670
V P D G YTC+ N +I HT Y +D V E S P++ I GL
Sbjct: 219 ESVVPSDKGNYTCVVENEYGSINHT----YHLD--VVERS-------PHRPILQAGLPAN 265
Query: 671 AAVAYIIAVLG--LMFYCKKRCKA-------KRLQKQPEGEEPE---------MECLNGG 712
A+ V+G + F CK A K ++K P+ + +
Sbjct: 266 AST-----VVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSS 320
Query: 713 PLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD-KMHFPRSSLQPITTLGKSEFGEVF 771
+ + P I ++ T+ A ++ D K FPR L LG+ FG+V
Sbjct: 321 SMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVV 380
Query: 772 LAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCRE 827
+A+A G+++ + V V KD+ + D E+EM + H N++ LLG C +
Sbjct: 381 MAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 440
Query: 828 AEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEH 880
P Y+++EY G+L+++LR + ++ + ++ K V+ Q+A GME+
Sbjct: 441 DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEY 500
Query: 881 LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAIL 939
L++ + +H+DLAARN LV+ +K++ GL++D+ N +YY +P++WM+PEA+
Sbjct: 501 LASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALF 560
Query: 940 EGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRL 999
+ ++ +SDVW+FGVLMWE+FT G P+ G +E+ L+ G R+ +P C ++LY +
Sbjct: 561 DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMM 619
Query: 1000 MQRCWALSPKDRPSFSEIASAL 1021
M+ CW P RP+F ++ L
Sbjct: 620 MRDCWHAVPSQRPTFKQLVEDL 641
Score = 47.0 bits (110), Expect = 9e-05
Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)
Query: 35 IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
I QP A G +RC ++ + W DG + R G L +
Sbjct: 44 ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100
Query: 95 DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
DSG + C A DD G E + S N + W
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160
Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
+ + A A V RC G+P PT +W ++G + V ++ +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216
Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
+ P G Y+C + +G + + L + + S R +L P + +
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274
Query: 243 MFHCQFSAQPPPSLQWL 259
F C+ + P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291
Score = 37.4 bits (85), Expect = 0.073
Identities = 58/273 (21%), Positives = 94/273 (34%), Gaps = 44/273 (16%)
Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
+P V+ A G V CL L + +V W GV L + R G L + D
Sbjct: 46 QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101
Query: 386 AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
+G+Y C A+ + V S E+ G D +++ + +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAIS------SGDDEDDTDGAEDFVSENSNNKRAPY 155
Query: 446 YRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
+ N + + R+++V + +RC PAG + +G
Sbjct: 156 WTNTEKMEK------------RLHAVPAANTVKFRC----PAGGNPMPTMRWLKNGKEFK 199
Query: 506 E-------WVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVA------VFI 552
+ V + +L V D GNYTC+ N G I L V +
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPIL 258
Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 585
+ +TV G + C+ D +P IQW
Sbjct: 259 QAGLPANASTVVGGDVEFV-CKVYSDAQPHIQW 290
Score = 37.0 bits (84), Expect = 0.096
Identities = 55/232 (23%), Positives = 87/232 (37%), Gaps = 56/232 (24%)
Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
K+ S+ E+ P + +RC + W +DG L G +N TV E L ++
Sbjct: 41 KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95
Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
A P SGLY+C A + F +++ D E F + A
Sbjct: 96 GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153
Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
P + E+ + F C P P+++WL F+ E I + R H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213
Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP 326
SL++ V P + G Y C+ + + G + T HL +E P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSP 253
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 211 bits (536), Expect = 4e-54
Identities = 177/598 (29%), Positives = 269/598 (44%), Gaps = 78/598 (13%)
Query: 482 MSSTPAGSIEAQARVQVLDGSSL--PEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQ 539
+S P G V V DG+ L E V L + +D+G Y+C +
Sbjct: 59 LSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVL 118
Query: 540 IRAHVQLT-------------------VAVFITFKVEPERT-----TVYQGHTALLQCEA 575
V++T V + PER V +T +C A
Sbjct: 119 CHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPA 178
Query: 576 QGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIK 633
G+P P I W K ++G Q SLV+ V P D G YTC+ N +I+
Sbjct: 179 AGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIR 238
Query: 634 HTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLG--LMFYCK---- 687
T Y +D V E S P++ I GL AVLG + F+CK
Sbjct: 239 QT----YTLD--VLERS-------PHRPILQAGLPANQT-----AVLGSDVEFHCKVYSD 280
Query: 688 --------KRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQ-EEVALTSLGSGPAA 738
K + + P+G P + L N S+ +A S G GP
Sbjct: 281 AQPHIQWLKHVEVNGSKVGPDGT-PYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTL 339
Query: 739 TNKRH---STSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK 795
N K R+ L LG+ FG+V +A+A G+++ A V V K
Sbjct: 340 ANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK 399
Query: 796 DEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK 851
D+ D E+EM + H N++ LLG C + P Y+++EY G+L++FLR +
Sbjct: 400 DDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR 459
Query: 852 ------SKDE-KLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQV 904
S D K + L+ K V+ QVA GME+L++ + +H+DLAARN LV+ +
Sbjct: 460 PPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVM 519
Query: 905 KVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHG 963
K++ GL++DV+N +YY +P++WM+PEA+ + ++ +SDVW+FGVL+WE+FT G
Sbjct: 520 KIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLG 579
Query: 964 EMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
P+ G +E+ L+ G R+ +P C LY +M+ CW +P RP+F ++ L
Sbjct: 580 GSPYPGIPVEELFKLLKEGH-RMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 636
Score = 53.5 bits (127), Expect = 1e-06
Identities = 55/259 (21%), Positives = 90/259 (34%), Gaps = 48/259 (18%)
Query: 37 QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
+P Q+ L G L C GP+ W+ DG + +ER L
Sbjct: 42 EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101
Query: 93 LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
+DSG + C R DD GE+ ++ G
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154
Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
P + + V RC G+P P+ W ++G + + H + ++
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211
Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
+L + P G Y+C + FG Q +TL + + S R +L P +
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269
Query: 241 EAMFHCQFSAQPPPSLQWL 259
+ FHC+ + P +QWL
Sbjct: 270 DVEFHCKVYSDAQPHIQWL 288
Score = 46.6 bits (109), Expect = 1e-04
Identities = 67/292 (22%), Positives = 96/292 (32%), Gaps = 59/292 (20%)
Query: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
E VF +G ++C PP G P W G L RV L + N + D+G
Sbjct: 47 EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106
Query: 389 YTCHAANLAGQRRQDVNITVATVPS------WLKKPQDSQLEEG-----KPGYLDCLTQA 437
Y+C L + ++ V PS + +D+ ++ G +P +D A
Sbjct: 107 YSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLA 165
Query: 438 TPKPTVVWYRNQMLISEDSRFEVFKN-----GTLRINSVEVYDGTWYRCMSSTPAGSIEA 492
P V +R + KN G RI +++ W M S
Sbjct: 166 VPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMES-------- 217
Query: 493 QARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVF- 551
V D GNYTC+ N G IR L V
Sbjct: 218 ---------------------------VVPSDRGNYTCVVEN-KFGSIRQTYTLDVLERS 249
Query: 552 ----ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGP 599
I P T G C+ D +P IQW K ++ +K+GP
Sbjct: 250 PHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL-KHVEVNGSKVGP 300
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,903,522
Number of Sequences: 37866
Number of extensions: 2269971
Number of successful extensions: 16613
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 617
Number of HSP's successfully gapped in prelim test: 521
Number of HSP's that attempted gapping in prelim test: 5890
Number of HSP's gapped (non-prelim): 5526
length of query: 1030
length of database: 18,247,518
effective HSP length: 112
effective length of query: 918
effective length of database: 14,006,526
effective search space: 12857990868
effective search space used: 12857990868
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.