Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 22902126

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor
[Homo sapiens]
         (1030 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [...  2097   0.0  
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [...  2077   0.0  
gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [...  1922   0.0  
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [...  1134   0.0  
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   238   2e-62
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   231   3e-60
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   231   3e-60
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   230   6e-60
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   230   6e-60
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   228   2e-59
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   227   4e-59
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   227   4e-59
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   224   2e-58
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   224   2e-58
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   223   6e-58
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...   221   3e-57
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   221   4e-57
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   220   5e-57
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...   220   6e-57
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   219   8e-57
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   219   1e-56
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   219   1e-56
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    217   4e-56
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   217   5e-56
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo...   216   9e-56
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   216   1e-55
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   216   1e-55
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...   214   3e-55
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   212   1e-54
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   211   4e-54

>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [Homo
            sapiens]
          Length = 1030

 Score = 2097 bits (5432), Expect = 0.0
 Identities = 1030/1030 (100%), Positives = 1030/1030 (100%)

Query: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
            MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60

Query: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
            VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120

Query: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
            IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180

Query: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
            KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240

Query: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
            EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300

Query: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
            CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360

Query: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
            VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420

Query: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
            SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480

Query: 481  CMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQI 540
            CMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQI
Sbjct: 481  CMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQI 540

Query: 541  RAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR 600
            RAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR
Sbjct: 541  RAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR 600

Query: 601  MHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYK 660
            MHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYK
Sbjct: 601  MHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYK 660

Query: 661  MIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPS 720
            MIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPS
Sbjct: 661  MIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPS 720

Query: 721  AEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEE 780
            AEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEE
Sbjct: 721  AEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEE 780

Query: 781  GVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDL 840
            GVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDL
Sbjct: 781  GVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDL 840

Query: 841  GDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA 900
            GDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA
Sbjct: 841  GDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSA 900

Query: 901  QRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVF 960
            QRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVF
Sbjct: 901  QRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVF 960

Query: 961  THGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASA 1020
            THGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASA
Sbjct: 961  THGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASA 1020

Query: 1021 LGDSTVDSKP 1030
            LGDSTVDSKP
Sbjct: 1021 LGDSTVDSKP 1030


>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [Homo
            sapiens]
          Length = 1070

 Score = 2077 bits (5381), Expect = 0.0
 Identities = 1030/1070 (96%), Positives = 1030/1070 (96%), Gaps = 40/1070 (3%)

Query: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
            MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60

Query: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
            VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120

Query: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
            IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180

Query: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
            KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240

Query: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
            EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300

Query: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
            CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360

Query: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
            VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420

Query: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
            SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480

Query: 481  CMSSTPAGSIEAQARVQVL----------------------------------------D 500
            CMSSTPAGSIEAQARVQVL                                        D
Sbjct: 481  CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540

Query: 501  GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 560
            GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
Sbjct: 541  GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600

Query: 561  TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 620
            TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG
Sbjct: 601  TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 660

Query: 621  RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 680
            RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
Sbjct: 661  RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 720

Query: 681  GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 740
            GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
Sbjct: 721  GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 780

Query: 741  KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 800
            KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
Sbjct: 781  KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 840

Query: 801  LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 860
            LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
Sbjct: 841  LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 900

Query: 861  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 920
            PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
Sbjct: 901  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 960

Query: 921  YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 980
            YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
Sbjct: 961  YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 1020

Query: 981  AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1030
            AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 1021 AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1070


>gi|22902130 PTK7 protein tyrosine kinase 7 isoform d precursor [Homo
            sapiens]
          Length = 1014

 Score = 1922 bits (4978), Expect = 0.0
 Identities = 970/1070 (90%), Positives = 971/1070 (90%), Gaps = 96/1070 (8%)

Query: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
            MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1    MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60

Query: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
            VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61   VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120

Query: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
            IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121  IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180

Query: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
            KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181  KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240

Query: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
            EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241  EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300

Query: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
            CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301  CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360

Query: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420
            VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD
Sbjct: 361  VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQD 420

Query: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480
            SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR
Sbjct: 421  SQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYR 480

Query: 481  CMSSTPAGSIEAQARVQVL----------------------------------------D 500
            CMSSTPAGSIEAQARVQVL                                        D
Sbjct: 481  CMSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTIKWERAD 540

Query: 501  GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 560
            GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER
Sbjct: 541  GSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPER 600

Query: 561  TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 620
            TTVYQGHTALLQCEAQGDPKPLIQWK K                           PE+S 
Sbjct: 601  TTVYQGHTALLQCEAQGDPKPLIQWKDKP-------------------------VPEES- 634

Query: 621  RYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 680
                                          EGPGSPPPYKMIQTIGLSVGAAVAYIIAVL
Sbjct: 635  ------------------------------EGPGSPPPYKMIQTIGLSVGAAVAYIIAVL 664

Query: 681  GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 740
            GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN
Sbjct: 665  GLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATN 724

Query: 741  KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 800
            KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ
Sbjct: 725  KRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQ 784

Query: 801  LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 860
            LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ
Sbjct: 785  LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ 844

Query: 861  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 920
            PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY
Sbjct: 845  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 904

Query: 921  YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 980
            YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ
Sbjct: 905  YHFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQ 964

Query: 981  AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1030
            AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 965  AGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDSTVDSKP 1014


>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [Homo
            sapiens]
          Length = 940

 Score = 1134 bits (2933), Expect = 0.0
 Identities = 623/926 (67%), Positives = 681/926 (73%), Gaps = 42/926 (4%)

Query: 129  VVLKHPASEAEIQPQTQVTLRCHIDGHPRPTY-QWFRDGTPLSDGQSNHTVSSKERNLTL 187
            V +K P+S+  +Q + +  LRC ++  P P +  W  DG P+ D +      S      +
Sbjct: 33   VFIKQPSSQDALQGR-RALLRCEVEA-PGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAV 90

Query: 188  RPAGPEHSGLYSCCAHS-AFGQACSSQNFTLSIADESFARVVLA--PQDVVVARYEEAMF 244
                 + SG + C A     G+   S N + +I       VVL     +  +    +   
Sbjct: 91   DRL--QDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTL 148

Query: 245  HCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQ 304
             C     P P+ QW F D TP+++                +L L    P ++G+Y C   
Sbjct: 149  RCHIDGHPRPTYQW-FRDGTPLSDGQS----NHTVSSKERNLTLRPAGPEHSGLYSCCAH 203

Query: 305  GQRGPPIILEA-TLHLAE--IEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEH--- 358
               G     +  TL +A+     + L    V  A  EE +        P PS+ W     
Sbjct: 204  SAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDE 263

Query: 359  ---AGVRLPTHGR---VYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVP 412
                    P H R   V+  G  L+L  +   +AG+Y C      GQR   + I  AT+ 
Sbjct: 264  TPITNRSRPPHLRRATVFANG-SLLLTQVRPRNAGIYRCIGQ---GQRGPPI-ILEATLH 318

Query: 413  SWLKKPQDSQLEE------GKPGYLDCLT-QATPKPTVVWYRNQMLISEDSRFEVFKNG- 464
              L + +D  L E      G    + CL  +  P+P+V W    + +    R  V++ G 
Sbjct: 319  --LAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGR--VYQKGH 374

Query: 465  TLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDD 524
             L + ++   D   Y C ++  AG       + V +GSSLPEWVTDNAGTLHFARVTRDD
Sbjct: 375  ELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDD 434

Query: 525  AGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQ 584
            AGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQ
Sbjct: 435  AGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQ 494

Query: 585  WKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK 644
            WKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK
Sbjct: 495  WKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDK 554

Query: 645  PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP 704
            PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP
Sbjct: 555  PVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGEEP 614

Query: 705  EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGK 764
            EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGK
Sbjct: 615  EMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKMHFPRSSLQPITTLGK 674

Query: 765  SEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGL 824
            SEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGL
Sbjct: 675  SEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGL 734

Query: 825  CREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNN 884
            CREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNN
Sbjct: 735  CREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVALGMEHLSNN 794

Query: 885  RFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFS 944
            RFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFS
Sbjct: 795  RFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSPEAILEGDFS 854

Query: 945  TKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW 1004
            TKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW
Sbjct: 855  TKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCW 914

Query: 1005 ALSPKDRPSFSEIASALGDSTVDSKP 1030
            ALSPKDRPSFSEIASALGDSTVDSKP
Sbjct: 915  ALSPKDRPSFSEIASALGDSTVDSKP 940



 Score =  854 bits (2207), Expect = 0.0
 Identities = 433/553 (78%), Positives = 453/553 (81%), Gaps = 53/553 (9%)

Query: 1   MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60
           MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP
Sbjct: 1   MGAARGSPARPRRLPLLSVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGP 60

Query: 61  VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120
           VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN
Sbjct: 61  VHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSANASFN 120

Query: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180
           IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS
Sbjct: 121 IKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS 180

Query: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240
           KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE
Sbjct: 181 KERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYE 240

Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300
           EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR
Sbjct: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYR 300

Query: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360
           CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG
Sbjct: 301 CIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAG 360

Query: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA---TVPSWLK- 416
           VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA   ++P W+  
Sbjct: 361 VRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVANGSSLPEWVTD 420

Query: 417 ----------------------------------------------KPQDSQLEEGKPGY 430
                                                         +P+ + + +G    
Sbjct: 421 NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTAL 480

Query: 431 LDCLTQATPKPTVVWYRNQMLISEDS---RFEVFKNGTLRINSVEVYDGTWYRCMSSTPA 487
           L C  Q  PKP + W     ++       R  +F+NG+L I+ V   D   Y C++    
Sbjct: 481 LQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC 540

Query: 488 GSIEAQARVQVLD 500
                +A + V+D
Sbjct: 541 NIKHTEAPLYVVD 553



 Score = 33.9 bits (76), Expect = 0.81
 Identities = 31/116 (26%), Positives = 43/116 (37%), Gaps = 19/116 (16%)

Query: 552 ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVI 611
           I F  +P      QG  ALL+CE +      + W     +LD   +      F  GS + 
Sbjct: 32  IVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLS 86

Query: 612 HDVAP--EDSGRYTCIAGN------------SCNIKHTEAPLYVVDKPVPEESEGP 653
                  +DSG + C+A +            S NIK  EA   V+  P  E    P
Sbjct: 87  FAAVDRLQDSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQP 142


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
            [Homo sapiens]
          Length = 806

 Score =  238 bits (608), Expect = 2e-62
 Identities = 209/753 (27%), Positives = 321/753 (42%), Gaps = 111/753 (14%)

Query: 329  EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
            E  VF +G    ++C PP G P     W   G  L    RV      L + N +  D+G 
Sbjct: 47   EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106

Query: 389  YTCHAANLAGQRRQDVNITVATVPS------WLKKPQDSQLEEGKPGY-----LDCLTQA 437
            Y+C    L  +     ++ V   PS         + +D+ ++ G P +     +D    A
Sbjct: 107  YSCRQ-RLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLA 165

Query: 438  TPKPTVVWYRNQMLISEDSRFEVFKNGTL-----RINSVEVYDGTWYRCMSSTPAGSIEA 492
             P    V +R     +        KNG       RI  +++    W   M S        
Sbjct: 166  VPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMES-------- 217

Query: 493  QARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFI 552
                                       V   D GNYTC+  N   G IR    L V    
Sbjct: 218  ---------------------------VVPSDRGNYTCVVEN-KFGSIRQTYTLDVLERS 249

Query: 553  TFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHI 603
              +       P   T   G      C+   D +P IQW  K   ++ +K+GP     + +
Sbjct: 250  PHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL-KHVEVNGSKVGPDGTPYVTV 308

Query: 604  FQNGS----------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEES-EG 652
             +             L +H+V  ED+G YTC+AGNS    H  A L V+  P  EE  E 
Sbjct: 309  LKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVL--PAEEELVEA 366

Query: 653  PGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKR---------LQKQPEGEE 703
              +   Y  I    LS G      I V+  +  C+ R   K+         + + P   +
Sbjct: 367  DEAGSVYAGI----LSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQ 422

Query: 704  PEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRH---STSDKMHFPRSSLQPIT 760
              +E  +   + +  P   I    A  S G GP   N          K    R+ L    
Sbjct: 423  VSLE--SNASMSSNTPLVRI----ARLSSGEGPTLANVSELELPADPKWELSRARLTLGK 476

Query: 761  TLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HA 816
             LG+  FG+V +A+A G+++  A   V V     KD+    D      E+EM   +  H 
Sbjct: 477  PLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHK 536

Query: 817  NVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDE-KLKSQPLSTKQKVA 869
            N++ LLG C +  P Y+++EY   G+L++FLR  +      S D  K   + L+ K  V+
Sbjct: 537  NIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVS 596

Query: 870  LCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWV 928
               QVA GME+L++ + +H+DLAARN LV+    +K++  GL++DV+N +YY       +
Sbjct: 597  CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRL 656

Query: 929  PLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ 988
            P++WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G  P+ G   +E+   L+ G  R+ +
Sbjct: 657  PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDK 715

Query: 989  PEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
            P  C   LY +M+ CW  +P  RP+F ++   L
Sbjct: 716  PANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 748



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 55/259 (21%), Positives = 90/259 (34%), Gaps = 48/259 (18%)

Query: 37  QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
           +P  Q+ L    G    L C     GP+    W+ DG  +  +ER       L       
Sbjct: 42  EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101

Query: 93  LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
            +DSG + C  R                    DD  GE+            ++ G     
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154

Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
            P    +    +     V  RC   G+P P+  W ++G    + +  H +       ++ 
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211

Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
           +L +    P   G Y+C   + FG     Q +TL + + S  R +L    P +       
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269

Query: 241 EAMFHCQFSAQPPPSLQWL 259
           +  FHC+  +   P +QWL
Sbjct: 270 DVEFHCKVYSDAQPHIQWL 288



 Score = 34.7 bits (78), Expect = 0.48
 Identities = 66/294 (22%), Positives = 97/294 (32%), Gaps = 62/294 (21%)

Query: 154 GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQ 213
           G P     W +DGT L   +    V    + L +  A  E SG YSC         C   
Sbjct: 66  GGPMGPTVWVKDGTGLVPSER---VLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC--- 119

Query: 214 NFTLSIAD-------------------ESFARVVLAPQDV-----VVARYEEAMFHCQFS 249
           +F++ + D                   ++ A     P+ +      V       F C  +
Sbjct: 120 HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAA 179

Query: 250 AQPPPSLQWLFED-ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
             P PS+ WL    E    +R     LR        SL++  V P + G Y C+ + + G
Sbjct: 180 GNPTPSISWLKNGREFRGEHRIGGIKLRHQ----QWSLVMESVVPSDRGNYTCVVENKFG 235

Query: 309 PPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA- 359
               +  T  L  +E  P        L   +    GS+    C           W +H  
Sbjct: 236 S---IRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVE 292

Query: 360 --GVRLPTHGRVY-------------QKGHELVLANIAESDAGVYTCHAANLAG 398
             G ++   G  Y             ++   L L N+   DAG YTC A N  G
Sbjct: 293 VNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIG 346


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
            [Homo sapiens]
          Length = 820

 Score =  231 bits (589), Expect = 3e-60
 Identities = 200/748 (26%), Positives = 319/748 (42%), Gaps = 137/748 (18%)

Query: 353  SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA--- 409
            S+ W   GV+L    R    G E+ + +   +D+G+Y C  ++ +G      ++ V+   
Sbjct: 63   SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122

Query: 410  --------------------------TVPSWLKKPQDSQLEEGKPGY----LDCLTQATP 439
                                        P W    +  +     P        C +  TP
Sbjct: 123  PSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTP 182

Query: 440  KPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVL 499
             PT+ W +N      D R          I   +V   TW   M S               
Sbjct: 183  NPTLRWLKNGKEFKPDHR----------IGGYKVRYATWSIIMDS--------------- 217

Query: 500  DGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVE-- 557
                                V   D GNYTCI  N   G I    QL V      +    
Sbjct: 218  --------------------VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERSPHRPILQ 256

Query: 558  ---PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGSL- 609
               P   TV  G      C+   DP+P IQW  K   ++ +K+GP     + I +   + 
Sbjct: 257  AGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQILKTAGVN 315

Query: 610  -------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYK 660
                   V+H  +V+ ED+G YTC+AGNS  + H  A L V++    EE     + P Y 
Sbjct: 316  TTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE--ALEERPAVMTSPLYL 373

Query: 661  MIQT-------IGLSVGAAVAYII------AVLGLMFYCKKRCKAKRLQKQPEGEEPEME 707
             I         I   VG+ + Y +      +         K  K+  L++Q         
Sbjct: 374  EIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSA 433

Query: 708  CLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--KMHFPRSSLQPITTLGKS 765
             +N G L        +     L+S G+   A    +   +  +   PR  L     LG+ 
Sbjct: 434  SMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEG 485

Query: 766  EFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVVRL 821
             FG+V LA+A GL++      T V VK L+S   ++ L D   E+EM   +  H N++ L
Sbjct: 486  CFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINL 545

Query: 822  LGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQKVALCTQV 874
            LG C +  P Y+++EY   G+L+++L+  +    +    P       LS+K  V+   QV
Sbjct: 546  LGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQV 605

Query: 875  ALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLRWM 933
            A GME+L++ + +H+DLAARN LV+    +K++  GL++D+++ +YY       +P++WM
Sbjct: 606  ARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWM 665

Query: 934  SPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCP 993
            +PEA+ +  ++ +SDVW+FGVL+WE+FT G  P+ G   +E+   L+ G  R+ +P  C 
Sbjct: 666  APEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSNCT 724

Query: 994  SKLYRLMQRCWALSPKDRPSFSEIASAL 1021
            ++LY +M+ CW   P  RP+F ++   L
Sbjct: 725  NELYMMMRDCWHAVPSQRPTFKQLVEDL 752



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 76/327 (23%), Positives = 121/327 (37%), Gaps = 73/327 (22%)

Query: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
           + P   + LRC +    + +  W RDG  L++  SN T  + E  + ++ + P  SGLY+
Sbjct: 45  VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100

Query: 200 CCAHSAFGQACSSQNFTLSIAD--------------------------ESFARVVLAPQD 233
           C   S  G    +  F+++++D                             A    +P+ 
Sbjct: 101 CVTSSPSGS--DTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEK 158

Query: 234 V-----VVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
           +      V   +   F C  S  P P+L+WL   +       +P H        +A  S+
Sbjct: 159 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 213

Query: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
           ++  V P + G Y CI + + G    +  T  L  +E  P        L   +    GS 
Sbjct: 214 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 270

Query: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
               C      P+P + W +H  V               L T G     K  E++ L N+
Sbjct: 271 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 329

Query: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
           +  DAG YTC A N  G       +TV
Sbjct: 330 SFEDAGEYTCLAGNSIGLSHHSAWLTV 356



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 54/248 (21%), Positives = 87/248 (35%), Gaps = 49/248 (19%)

Query: 48  RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
           R  LR +V++     + WL DG  + ++ R    G  +     D +  DSG + CV    
Sbjct: 54  RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106

Query: 105 -------------------------DDVTGEEARSANASFNIK---WIEAGPVVLKHPAS 136
                                    DD + EE  + N   N     W     +  K  A 
Sbjct: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAV 166

Query: 137 EAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEH 194
            A       V  +C   G P PT +W ++G           + V     ++ +    P  
Sbjct: 167 PAA----KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSD 222

Query: 195 SGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQ 251
            G Y+C   + +G    +  + L + + S  R +L    P +  VA      F C+  + 
Sbjct: 223 KGNYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD 280

Query: 252 PPPSLQWL 259
           P P +QWL
Sbjct: 281 PQPHIQWL 288


>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
            [Homo sapiens]
          Length = 822

 Score =  231 bits (588), Expect = 3e-60
 Identities = 202/750 (26%), Positives = 323/750 (43%), Gaps = 139/750 (18%)

Query: 353  SVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVA-TV 411
            S+ W   GV+L    R    G E+ + +   +D+G+Y C  ++ +G      ++ V+  +
Sbjct: 63   SINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDAL 122

Query: 412  PSWLKKPQDS-------QLEEGKPGYLD---------------------------CLTQA 437
            PS      D        + +  KP  +                            C +  
Sbjct: 123  PSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSG 182

Query: 438  TPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQ 497
            TP PT+ W +N      D R          I   +V   TW   M S             
Sbjct: 183  TPNPTLRWLKNGKEFKPDHR----------IGGYKVRYATWSIIMDS------------- 219

Query: 498  VLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVE 557
                                  V   D GNYTCI  N   G I    QL V      +  
Sbjct: 220  ----------------------VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERSPHRPI 256

Query: 558  -----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS 608
                 P   TV  G      C+   DP+P IQW  K   ++ +K+GP     + I +   
Sbjct: 257  LQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQILKTAG 315

Query: 609  L--------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPP 658
            +        V+H  +V+ ED+G YTC+AGNS  + H  A L V++    EE     + P 
Sbjct: 316  VNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE--ALEERPAVMTSPL 373

Query: 659  YKMIQT-------IGLSVGAAVAYII------AVLGLMFYCKKRCKAKRLQKQPEGEEPE 705
            Y  I         I   VG+ + Y +      +         K  K+  L++Q       
Sbjct: 374  YLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADS 433

Query: 706  MECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--KMHFPRSSLQPITTLG 763
               +N G L        +     L+S G+   A    +   +  +   PR  L     LG
Sbjct: 434  SASMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLG 485

Query: 764  KSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN-HANVV 819
            +  FG+V LA+A GL++      T V VK L+S   ++ L D   E+EM   +  H N++
Sbjct: 486  EGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNII 545

Query: 820  RLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQKVALCT 872
             LLG C +  P Y+++EY   G+L+++L+  +    +    P       LS+K  V+   
Sbjct: 546  NLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAY 605

Query: 873  QVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWVPLR 931
            QVA GME+L++ + +H+DLAARN LV+    +K++  GL++D+++ +YY       +P++
Sbjct: 606  QVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVK 665

Query: 932  WMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEG 991
            WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G  P+ G   +E+   L+ G  R+ +P  
Sbjct: 666  WMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RMDKPSN 724

Query: 992  CPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
            C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 725  CTNELYMMMRDCWHAVPSQRPTFKQLVEDL 754



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 79/327 (24%), Positives = 124/327 (37%), Gaps = 71/327 (21%)

Query: 140 IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYS 199
           + P   + LRC +    + +  W RDG  L++  SN T  + E  + ++ + P  SGLY+
Sbjct: 45  VHPGDLLQLRCRLRDDVQ-SINWLRDGVQLAE--SNRTRITGEE-VEVQDSVPADSGLYA 100

Query: 200 CCAHSAFGQACSSQNFTLSIA----------DESFA-----------RVVLAPQDVVVAR 238
           C   S  G   +  +  +S A          D+S +           R+ +AP      +
Sbjct: 101 CVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEK 160

Query: 239 YEEAM----------FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSL 286
            E+ +          F C  S  P P+L+WL   +       +P H        +A  S+
Sbjct: 161 MEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSI 215

Query: 287 LLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSE 338
           ++  V P + G Y CI + + G    +  T  L  +E  P        L   +    GS 
Sbjct: 216 IMDSVVPSDKGNYTCIVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSN 272

Query: 339 ERVTCLPPKGLPEPSVWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANI 381
               C      P+P + W +H  V               L T G     K  E++ L N+
Sbjct: 273 VEFMCKVYSD-PQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNV 331

Query: 382 AESDAGVYTCHAANLAGQRRQDVNITV 408
           +  DAG YTC A N  G       +TV
Sbjct: 332 SFEDAGEYTCLAGNSIGLSHHSAWLTV 358



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 51/246 (20%), Positives = 87/246 (35%), Gaps = 43/246 (17%)

Query: 48  RALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ-DSGTFQCVAR-- 104
           R  LR +V++     + WL DG  + ++ R    G  +     D +  DSG + CV    
Sbjct: 54  RCRLRDDVQS-----INWLRDGVQLAESNRTRITGEEVEVQ--DSVPADSGLYACVTSSP 106

Query: 105 -------------------------DDVTGEEARSANASFNIKWIEAGPVVLKHPASEAE 139
                                    DD + EE  + N   N   +       +    +  
Sbjct: 107 SGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLH 166

Query: 140 IQPQTQ-VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSG 196
             P  + V  +C   G P PT +W ++G           + V     ++ +    P   G
Sbjct: 167 AVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKG 226

Query: 197 LYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPP 253
            Y+C   + +G    +  + L + + S  R +L    P +  VA      F C+  + P 
Sbjct: 227 NYTCIVENEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQ 284

Query: 254 PSLQWL 259
           P +QWL
Sbjct: 285 PHIQWL 290


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
            [Homo sapiens]
          Length = 802

 Score =  230 bits (586), Expect = 6e-60
 Identities = 213/757 (28%), Positives = 339/757 (44%), Gaps = 72/757 (9%)

Query: 308  GPPII-LEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK----GLPEPSVWWEHAGVR 362
            GPP++ LEA+    E+E  P   P +     E  V    P     G  E    W   G R
Sbjct: 16   GPPVLSLEAS---EEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSR 72

Query: 363  LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQ 422
            L   GRV      L +A+    DAG Y C A    G      N+T+ T  S      D  
Sbjct: 73   LAPAGRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTLITGDSLTSSNDD-- 127

Query: 423  LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCM 482
             E+ K         + P+    W   Q +               ++++V   +   +RC 
Sbjct: 128  -EDPKSHRDPSNRHSYPQQAPYWTHPQRMEK-------------KLHAVPAGNTVKFRCP 173

Query: 483  SS-TPAGSIEAQARVQVLDGSSLPEWVT--DNAGTLHFARVTRDDAGNYTCIASNGPQGQ 539
            ++  P  +I      Q   G +    +       +L    V   D G YTC+  N   G 
Sbjct: 174  AAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAV-GS 232

Query: 540  IRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDP 594
            IR +  L V      +       P  TT   G    L C+   D +P IQW  K  +++ 
Sbjct: 233  IRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL-KHIVING 291

Query: 595  TKLG----PRMHIFQNGS--------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 642
            +  G    P + + +           L + +V+ ED+G YTC+AGNS  + +  A L V+
Sbjct: 292  SSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL 351

Query: 643  DKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL--GLMFYCKKRCKAKRLQKQPE 700
             +  P  +          +I     S+  AV  ++A L  G   + +       +QK   
Sbjct: 352  PEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSR 411

Query: 701  GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM----HFPRSSL 756
                    L  G   +G+ S+ +   V L+S  SGPA      S    +     FPR  L
Sbjct: 412  FPLARQFSLESG--SSGKSSSSLVRGVRLSS--SGPALLAGLVSLDLPLDPLWEFPRDRL 467

Query: 757  QPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKL 813
                 LG+  FG+V  A+A G++    +  + V VK L+     + L D   E+E+   +
Sbjct: 468  VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLI 527

Query: 814  N-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDEKLKSQ-PLSTK 865
              H N++ LLG+C +  P Y+++E    G+L++FLR  +      S D    S+ PLS  
Sbjct: 528  GRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFP 587

Query: 866  QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FR 924
              V+   QVA GM++L + + +H+DLAARN LV+    +K++  GL++ V++ +YY    
Sbjct: 588  VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS 647

Query: 925  QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA 984
               +P++WM+PEA+ +  ++ +SDVW+FG+L+WE+FT G  P+ G   +E+ + L+ G  
Sbjct: 648  NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH- 706

Query: 985  RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
            R+ +P  CP +LY LM+ CW  +P  RP+F ++  AL
Sbjct: 707  RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 46/212 (21%), Positives = 74/212 (34%), Gaps = 26/212 (12%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W +DG           +  + +  +L +    P   G Y+C   
Sbjct: 168 VKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVE 227

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWLF 260
           +A G      N+ L + + S  R +L    P +       +    C+  +   P +QWL 
Sbjct: 228 NAVGSI--RYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLK 285

Query: 261 E----------DETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP 310
                      D  P     +   +  + V     L L  V   +AG Y C+     G  
Sbjct: 286 HIVINGSSFGADGFPYVQVLKTADINSSEVEV---LYLRNVSAEDAGEYTCLAGNSIG-- 340

Query: 311 IILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
                +   A +  +P  +P    A  E R T
Sbjct: 341 ----LSYQSAWLTVLPEEDPTWTAAAPEARYT 368


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
            [Homo sapiens]
          Length = 802

 Score =  230 bits (586), Expect = 6e-60
 Identities = 213/757 (28%), Positives = 339/757 (44%), Gaps = 72/757 (9%)

Query: 308  GPPII-LEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK----GLPEPSVWWEHAGVR 362
            GPP++ LEA+    E+E  P   P +     E  V    P     G  E    W   G R
Sbjct: 16   GPPVLSLEAS---EEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSR 72

Query: 363  LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQ 422
            L   GRV      L +A+    DAG Y C A    G      N+T+ T  S      D  
Sbjct: 73   LAPAGRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTLITGDSLTSSNDD-- 127

Query: 423  LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCM 482
             E+ K         + P+    W   Q +               ++++V   +   +RC 
Sbjct: 128  -EDPKSHRDPSNRHSYPQQAPYWTHPQRMEK-------------KLHAVPAGNTVKFRCP 173

Query: 483  SS-TPAGSIEAQARVQVLDGSSLPEWVT--DNAGTLHFARVTRDDAGNYTCIASNGPQGQ 539
            ++  P  +I      Q   G +    +       +L    V   D G YTC+  N   G 
Sbjct: 174  AAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAV-GS 232

Query: 540  IRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDP 594
            IR +  L V      +       P  TT   G    L C+   D +P IQW  K  +++ 
Sbjct: 233  IRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL-KHIVING 291

Query: 595  TKLG----PRMHIFQNGS--------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 642
            +  G    P + + +           L + +V+ ED+G YTC+AGNS  + +  A L V+
Sbjct: 292  SSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL 351

Query: 643  DKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVL--GLMFYCKKRCKAKRLQKQPE 700
             +  P  +          +I     S+  AV  ++A L  G   + +       +QK   
Sbjct: 352  PEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSR 411

Query: 701  GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM----HFPRSSL 756
                    L  G   +G+ S+ +   V L+S  SGPA      S    +     FPR  L
Sbjct: 412  FPLARQFSLESG--SSGKSSSSLVRGVRLSS--SGPALLAGLVSLDLPLDPLWEFPRDRL 467

Query: 757  QPITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKL 813
                 LG+  FG+V  A+A G++    +  + V VK L+     + L D   E+E+   +
Sbjct: 468  VLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLI 527

Query: 814  N-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDEKLKSQ-PLSTK 865
              H N++ LLG+C +  P Y+++E    G+L++FLR  +      S D    S+ PLS  
Sbjct: 528  GRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFP 587

Query: 866  QKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FR 924
              V+   QVA GM++L + + +H+DLAARN LV+    +K++  GL++ V++ +YY    
Sbjct: 588  VLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTS 647

Query: 925  QAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKA 984
               +P++WM+PEA+ +  ++ +SDVW+FG+L+WE+FT G  P+ G   +E+ + L+ G  
Sbjct: 648  NGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH- 706

Query: 985  RLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
            R+ +P  CP +LY LM+ CW  +P  RP+F ++  AL
Sbjct: 707  RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 743



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 46/212 (21%), Positives = 74/212 (34%), Gaps = 26/212 (12%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W +DG           +  + +  +L +    P   G Y+C   
Sbjct: 168 VKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVE 227

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWLF 260
           +A G      N+ L + + S  R +L    P +       +    C+  +   P +QWL 
Sbjct: 228 NAVGSI--RYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLK 285

Query: 261 E----------DETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPP 310
                      D  P     +   +  + V     L L  V   +AG Y C+     G  
Sbjct: 286 HIVINGSSFGADGFPYVQVLKTADINSSEVEV---LYLRNVSAEDAGEYTCLAGNSIG-- 340

Query: 311 IILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
                +   A +  +P  +P    A  E R T
Sbjct: 341 ----LSYQSAWLTVLPEEDPTWTAAAPEARYT 368


>gi|221316639 fibroblast growth factor receptor 2 isoform 1 precursor
            [Homo sapiens]
          Length = 821

 Score =  228 bits (581), Expect = 2e-59
 Identities = 195/752 (25%), Positives = 325/752 (43%), Gaps = 99/752 (13%)

Query: 329  EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
            +P V+ A  G    V CL    L + +V  W   GV L  + R    G  L +      D
Sbjct: 46   QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101

Query: 386  AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
            +G+Y C A+           + V    S          E+   G  D +++ +      +
Sbjct: 102  SGLYACTASRTVDSETWYFMVNVTDAIS------SGDDEDDTDGAEDFVSENSNNKRAPY 155

Query: 446  YRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
            + N   + +            R+++V   +   +RC    PAG         + +G    
Sbjct: 156  WTNTEKMEK------------RLHAVPAANTVKFRC----PAGGNPMPTMRWLKNGKEFK 199

Query: 506  EW-------VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FI 552
            +        V +   +L    V   D GNYTC+  N   G I     L V         +
Sbjct: 200  QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPIL 258

Query: 553  TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS 608
               +    +TV  G    + C+   D +P IQW  K    + +K GP     + + +   
Sbjct: 259  QAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAG 316

Query: 609  ----------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPP 658
                      L I +V  ED+G YTC+AGNS  I    A L V+  P P   +   + P 
Sbjct: 317  VNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPD 374

Query: 659  YKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNG 717
            Y  I    + V      ++ V+         C+ K   K+P+   +P +  L        
Sbjct: 375  YLEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRR 426

Query: 718  QPSAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITT 761
            Q +   +   ++ S       T +  ST+D                K  FPR  L     
Sbjct: 427  QVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKP 486

Query: 762  LGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HAN 817
            LG+  FG+V +A+A G+++   +  V V     KD+  + D      E+EM   +  H N
Sbjct: 487  LGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKN 546

Query: 818  VVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVAL 870
            ++ LLG C +  P Y+++EY   G+L+++LR  +           ++  + ++ K  V+ 
Sbjct: 547  IINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSC 606

Query: 871  CTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVP 929
              Q+A GME+L++ + +H+DLAARN LV+    +K++  GL++D+ N +YY       +P
Sbjct: 607  TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLP 666

Query: 930  LRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQP 989
            ++WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ G   +E+   L+ G  R+ +P
Sbjct: 667  VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKP 725

Query: 990  EGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
              C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 726  ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 757



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)

Query: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100

Query: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160

Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216

Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
            +    P   G Y+C   + +G    +  + L + + S  R +L    P +       + 
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274

Query: 243 MFHCQFSAQPPPSLQWL 259
            F C+  +   P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 79/343 (23%), Positives = 118/343 (34%), Gaps = 82/343 (23%)

Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95

Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
                     SL++  V P + G Y C+ + + G    +  T HL  +E  P        
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261

Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQKG--------- 373
           L        G +    C       +P + W    E  G +    G  Y K          
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTT 320

Query: 374 ----HELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVP 412
                 L + N+   DAG YTC A N  G       +TV   P
Sbjct: 321 DKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAP 363


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
            [Homo sapiens]
          Length = 790

 Score =  227 bits (579), Expect = 4e-59
 Identities = 174/587 (29%), Positives = 270/587 (45%), Gaps = 50/587 (8%)

Query: 470  SVEVYDGTWYRCMSS----TPAGSI--EAQARVQVLDGSSLPEWVTDNAGTLHFARVTRD 523
            SV+V D    RC         AG I  E +    V+    LP         L  A VT D
Sbjct: 204  SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL------GLTLANVTSD 257

Query: 524  -DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPL 582
             +  N TC A N          +++V V ++F    +  T  + H   +     G P P 
Sbjct: 258  LNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPS 312

Query: 583  IQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHT 635
            ++W     +L+ T       L P  +   ++G L ++     ++G YT +A N       
Sbjct: 313  LRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASA 372

Query: 636  EAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA-----YIIAVLGL 682
                  +D P        +P+ +   G P   K     G+SV   +A     ++  +L +
Sbjct: 373  SIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLV 432

Query: 683  MFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKR 742
            +  C +R K      +P    PE              S+    E   + L        + 
Sbjct: 433  LNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQY 490

Query: 743  HSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD 802
             S +   H  R  +     LG+  FG+VFLA+   L     + LV VK+L+   E  + D
Sbjct: 491  FSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD 550

Query: 803  FRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKS--- 859
            F+RE E+   L H ++VR  G+C E  P  MV EY+  GDL +FLR S   D KL +   
Sbjct: 551  FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGPDAKLLAGGE 609

Query: 860  ----QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV 915
                 PL   Q +A+ +QVA GM +L+   FVH+DLA RNCLV     VK+   G+S+D+
Sbjct: 610  DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI 669

Query: 916  YNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDE 974
            Y+++YY    +  +P+RWM PE+IL   F+T+SDVW+FGV++WE+FT+G+ P    ++ E
Sbjct: 670  YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE 729

Query: 975  VLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
             +  +  G+  L +P  CP ++Y +M+ CW   P+ R S  ++ + L
Sbjct: 730  AIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 775



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)

Query: 46  GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
           G   LLRC+VE  G     W+L       T  +     SL     +   D       C A
Sbjct: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267

Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
            +DV   E +   N SF              PAS   +Q  T V +        +DG P 
Sbjct: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310

Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
           P+ +W  +G+ L++     T       +   R+  LR   P H  +G Y+  A + FGQA
Sbjct: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370

Query: 210 CSS 212
            +S
Sbjct: 371 SAS 373



 Score = 30.8 bits (68), Expect = 6.9
 Identities = 31/139 (22%), Positives = 53/139 (38%), Gaps = 21/139 (15%)

Query: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
           L LAN+ ++ +    TC A N  G+    V + V+        P   QL      +  C+
Sbjct: 249 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 301

Query: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
                  P P++ W  N  +++E S            E  ++G LR+N     +   Y  
Sbjct: 302 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 361

Query: 482 MSSTPAGSIEAQARVQVLD 500
           +++ P G   A      +D
Sbjct: 362 LAANPFGQASASIMAAFMD 380


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
            [Homo sapiens]
          Length = 760

 Score =  227 bits (579), Expect = 4e-59
 Identities = 174/587 (29%), Positives = 270/587 (45%), Gaps = 50/587 (8%)

Query: 470  SVEVYDGTWYRCMSS----TPAGSI--EAQARVQVLDGSSLPEWVTDNAGTLHFARVTRD 523
            SV+V D    RC         AG I  E +    V+    LP         L  A VT D
Sbjct: 174  SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL------GLTLANVTSD 227

Query: 524  -DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPL 582
             +  N TC A N          +++V V ++F    +  T  + H   +     G P P 
Sbjct: 228  LNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPS 282

Query: 583  IQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHT 635
            ++W     +L+ T       L P  +   ++G L ++     ++G YT +A N       
Sbjct: 283  LRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASA 342

Query: 636  EAPLYVVDKP--------VPEESEGPGSPPPYKMIQTIGLSVGAAVA-----YIIAVLGL 682
                  +D P        +P+ +   G P   K     G+SV   +A     ++  +L +
Sbjct: 343  SIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLV 402

Query: 683  MFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKR 742
            +  C +R K      +P    PE              S+    E   + L        + 
Sbjct: 403  LNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQY 460

Query: 743  HSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLD 802
             S +   H  R  +     LG+  FG+VFLA+   L     + LV VK+L+   E  + D
Sbjct: 461  FSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD 520

Query: 803  FRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKS--- 859
            F+RE E+   L H ++VR  G+C E  P  MV EY+  GDL +FLR S   D KL +   
Sbjct: 521  FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGPDAKLLAGGE 579

Query: 860  ----QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDV 915
                 PL   Q +A+ +QVA GM +L+   FVH+DLA RNCLV     VK+   G+S+D+
Sbjct: 580  DVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDI 639

Query: 916  YNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDE 974
            Y+++YY    +  +P+RWM PE+IL   F+T+SDVW+FGV++WE+FT+G+ P    ++ E
Sbjct: 640  YSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTE 699

Query: 975  VLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
             +  +  G+  L +P  CP ++Y +M+ CW   P+ R S  ++ + L
Sbjct: 700  AIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 745



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)

Query: 46  GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
           G   LLRC+VE  G     W+L       T  +     SL     +   D       C A
Sbjct: 178 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 237

Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
            +DV   E +   N SF              PAS   +Q  T V +        +DG P 
Sbjct: 238 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 280

Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
           P+ +W  +G+ L++     T       +   R+  LR   P H  +G Y+  A + FGQA
Sbjct: 281 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 340

Query: 210 CSS 212
            +S
Sbjct: 341 SAS 343



 Score = 30.8 bits (68), Expect = 6.9
 Identities = 31/139 (22%), Positives = 53/139 (38%), Gaps = 21/139 (15%)

Query: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
           L LAN+ ++ +    TC A N  G+    V + V+        P   QL      +  C+
Sbjct: 219 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 271

Query: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
                  P P++ W  N  +++E S            E  ++G LR+N     +   Y  
Sbjct: 272 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 331

Query: 482 MSSTPAGSIEAQARVQVLD 500
           +++ P G   A      +D
Sbjct: 332 LAANPFGQASASIMAAFMD 350


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
            [Homo sapiens]
          Length = 731

 Score =  224 bits (572), Expect = 2e-58
 Identities = 183/635 (28%), Positives = 286/635 (45%), Gaps = 104/635 (16%)

Query: 433  CLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEA 492
            C +  TP PT+ W +N      D R          I   +V   TW   M S        
Sbjct: 87   CPSSGTPNPTLRWLKNGKEFKPDHR----------IGGYKVRYATWSIIMDS-------- 128

Query: 493  QARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFI 552
                                       V   D GNYTCI  N   G I    QL V    
Sbjct: 129  ---------------------------VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERS 160

Query: 553  TFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHI 603
              +       P   TV  G      C+   DP+P IQW  K   ++ +K+GP     + I
Sbjct: 161  PHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQI 219

Query: 604  FQNGSL--------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGP 653
             +   +        V+H  +V+ ED+G YTC+AGNS  + H  A L V++    EE    
Sbjct: 220  LKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE--ALEERPAV 277

Query: 654  GSPPPYKMIQT-------IGLSVGAAVAYII------AVLGLMFYCKKRCKAKRLQKQPE 700
             + P Y  I         I   VG+ + Y +      +         K  K+  L++Q  
Sbjct: 278  MTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVT 337

Query: 701  GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--KMHFPRSSLQP 758
                    +N G L        +     L+S G+   A    +   +  +   PR  L  
Sbjct: 338  VSADSSASMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 389

Query: 759  ITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN- 814
               LG+  FG+V LA+A GL++      T V VK L+S   ++ L D   E+EM   +  
Sbjct: 390  GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 449

Query: 815  HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQK 867
            H N++ LLG C +  P Y+++EY   G+L+++L+  +    +    P       LS+K  
Sbjct: 450  HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 509

Query: 868  VALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQA 926
            V+   QVA GME+L++ + +H+DLAARN LV+    +K++  GL++D+++ +YY      
Sbjct: 510  VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 569

Query: 927  WVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARL 986
             +P++WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G  P+ G   +E+   L+ G  R+
Sbjct: 570  RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RM 628

Query: 987  PQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
             +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 629  DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 663



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  +C   G P PT +W ++G           + V     ++ +    P   G Y+C   
Sbjct: 83  VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 142

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +  VA      F C+  + P P +QWL
Sbjct: 143 NEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 199



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 15/122 (12%)

Query: 555 KVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT-KLGPRMHIFQNGSLVIHD 613
           K+E +   V    T   +C + G P P ++W    +   P  ++G     +   S+++  
Sbjct: 69  KMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDS 128

Query: 614 VAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAA 672
           V P D G YTCI  N   +I HT    Y +D  V E S       P++ I   GL     
Sbjct: 129 VVPSDKGNYTCIVENEYGSINHT----YQLD--VVERS-------PHRPILQAGLPANKT 175

Query: 673 VA 674
           VA
Sbjct: 176 VA 177



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 50/192 (26%), Positives = 72/192 (37%), Gaps = 36/192 (18%)

Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSLLLTQVRPRNAGIYRC 301
           F C  S  P P+L+WL   +       +P H        +A  S+++  V P + G Y C
Sbjct: 85  FKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 139

Query: 302 IGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPS 353
           I + + G    +  T  L  +E  P        L   +    GS     C      P+P 
Sbjct: 140 IVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD-PQPH 195

Query: 354 VWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANIAESDAGVYTCHAANL 396
           + W +H  V               L T G     K  E++ L N++  DAG YTC A N 
Sbjct: 196 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS 255

Query: 397 AGQRRQDVNITV 408
            G       +TV
Sbjct: 256 IGLSHHSAWLTV 267


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
            [Homo sapiens]
          Length = 733

 Score =  224 bits (572), Expect = 2e-58
 Identities = 183/635 (28%), Positives = 286/635 (45%), Gaps = 104/635 (16%)

Query: 433  CLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEA 492
            C +  TP PT+ W +N      D R          I   +V   TW   M S        
Sbjct: 89   CPSSGTPNPTLRWLKNGKEFKPDHR----------IGGYKVRYATWSIIMDS-------- 130

Query: 493  QARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFI 552
                                       V   D GNYTCI  N   G I    QL V    
Sbjct: 131  ---------------------------VVPSDKGNYTCIVEN-EYGSINHTYQLDVVERS 162

Query: 553  TFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR----MHI 603
              +       P   TV  G      C+   DP+P IQW  K   ++ +K+GP     + I
Sbjct: 163  PHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL-KHIEVNGSKIGPDNLPYVQI 221

Query: 604  FQNGSL--------VIH--DVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGP 653
             +   +        V+H  +V+ ED+G YTC+AGNS  + H  A L V++    EE    
Sbjct: 222  LKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE--ALEERPAV 279

Query: 654  GSPPPYKMIQT-------IGLSVGAAVAYII------AVLGLMFYCKKRCKAKRLQKQPE 700
             + P Y  I         I   VG+ + Y +      +         K  K+  L++Q  
Sbjct: 280  MTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVT 339

Query: 701  GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD--KMHFPRSSLQP 758
                    +N G L        +     L+S G+   A    +   +  +   PR  L  
Sbjct: 340  VSADSSASMNSGVL--------LVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVL 391

Query: 759  ITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN- 814
               LG+  FG+V LA+A GL++      T V VK L+S   ++ L D   E+EM   +  
Sbjct: 392  GKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGK 451

Query: 815  HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQP-------LSTKQK 867
            H N++ LLG C +  P Y+++EY   G+L+++L+  +    +    P       LS+K  
Sbjct: 452  HKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDL 511

Query: 868  VALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQA 926
            V+   QVA GME+L++ + +H+DLAARN LV+    +K++  GL++D+++ +YY      
Sbjct: 512  VSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNG 571

Query: 927  WVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARL 986
             +P++WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G  P+ G   +E+   L+ G  R+
Sbjct: 572  RLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH-RM 630

Query: 987  PQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
             +P  C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 631  DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 665



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  +C   G P PT +W ++G           + V     ++ +    P   G Y+C   
Sbjct: 85  VKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVE 144

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +  VA      F C+  + P P +QWL
Sbjct: 145 NEYGSI--NHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWL 201



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 15/122 (12%)

Query: 555 KVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPT-KLGPRMHIFQNGSLVIHD 613
           K+E +   V    T   +C + G P P ++W    +   P  ++G     +   S+++  
Sbjct: 71  KMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDS 130

Query: 614 VAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAA 672
           V P D G YTCI  N   +I HT    Y +D  V E S       P++ I   GL     
Sbjct: 131 VVPSDKGNYTCIVENEYGSINHT----YQLD--VVERS-------PHRPILQAGLPANKT 177

Query: 673 VA 674
           VA
Sbjct: 178 VA 179



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 50/192 (26%), Positives = 72/192 (37%), Gaps = 36/192 (18%)

Query: 244 FHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRA--TVFANGSLLLTQVRPRNAGIYRC 301
           F C  S  P P+L+WL   +       +P H        +A  S+++  V P + G Y C
Sbjct: 87  FKCPSSGTPNPTLRWLKNGK-----EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTC 141

Query: 302 IGQGQRGPPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPS 353
           I + + G    +  T  L  +E  P        L   +    GS     C      P+P 
Sbjct: 142 IVENEYGS---INHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSD-PQPH 197

Query: 354 VWW-EHAGVR--------------LPTHG-RVYQKGHELV-LANIAESDAGVYTCHAANL 396
           + W +H  V               L T G     K  E++ L N++  DAG YTC A N 
Sbjct: 198 IQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNS 257

Query: 397 AGQRRQDVNITV 408
            G       +TV
Sbjct: 258 IGLSHHSAWLTV 269


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
            [Homo sapiens]
          Length = 796

 Score =  223 bits (569), Expect = 6e-58
 Identities = 175/593 (29%), Positives = 268/593 (45%), Gaps = 56/593 (9%)

Query: 470  SVEVYDGTWYRCMSS----TPAGSI--EAQARVQVLDGSSLPEWVTDNAGTLHFARVTRD 523
            SV+V D    RC         AG I  E +    V+    LP         L  A VT D
Sbjct: 204  SVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSL------GLTLANVTSD 257

Query: 524  -DAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPL 582
             +  N TC A N          +++V V ++F    +  T  + H   +     G P P 
Sbjct: 258  LNRKNVTCWAENDV-----GRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPS 312

Query: 583  IQWKGKDRILDPTK------LGPRMH-IFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHT 635
            ++W     +L+ T       L P  +   ++G L ++     ++G YT +A N       
Sbjct: 313  LRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASA 372

Query: 636  EAPLYVVDKPVPEESEGP--------------GSPPPYKMIQTIGLSVGAAVA-----YI 676
                  +D P     E P              G P   K     G+SV   +A     ++
Sbjct: 373  SIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFL 432

Query: 677  IAVLGLMFYCKKRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGP 736
              +L ++  C +R K      +P    PE              S+    E   + L    
Sbjct: 433  STLLLVLNKCGRRNKFGI--NRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHI 490

Query: 737  AATNKRHSTSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKD 796
                +  S +   H  R  +     LG+  FG+VFLA+   L     + LV VK+L+   
Sbjct: 491  IENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEAS 550

Query: 797  EQQQLDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEK 856
            E  + DF+RE E+   L H ++VR  G+C E  P  MV EY+  GDL +FLR S   D K
Sbjct: 551  ESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR-SHGPDAK 609

Query: 857  LKS-------QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL 909
            L +        PL   Q +A+ +QVA GM +L+   FVH+DLA RNCLV     VK+   
Sbjct: 610  LLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDF 669

Query: 910  GLSKDVYNSEYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHG 968
            G+S+D+Y+++YY    +  +P+RWM PE+IL   F+T+SDVW+FGV++WE+FT+G+ P  
Sbjct: 670  GMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWY 729

Query: 969  GQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
              ++ E +  +  G+  L +P  CP ++Y +M+ CW   P+ R S  ++ + L
Sbjct: 730  QLSNTEAIDCITQGR-ELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL 781



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 49/183 (26%), Positives = 70/183 (38%), Gaps = 33/183 (18%)

Query: 46  GRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG--TFQCVA 103
           G   LLRC+VE  G     W+L       T  +     SL     +   D       C A
Sbjct: 208 GDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWA 267

Query: 104 RDDV-TGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLR-----CHIDGHPR 157
            +DV   E +   N SF              PAS   +Q  T V +        +DG P 
Sbjct: 268 ENDVGRAEVSVQVNVSF--------------PAS---VQLHTAVEMHHWCIPFSVDGQPA 310

Query: 158 PTYQWFRDGTPLSDGQSNHT------VSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQA 209
           P+ +W  +G+ L++     T       +   R+  LR   P H  +G Y+  A + FGQA
Sbjct: 311 PSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQA 370

Query: 210 CSS 212
            +S
Sbjct: 371 SAS 373



 Score = 30.8 bits (68), Expect = 6.9
 Identities = 31/139 (22%), Positives = 53/139 (38%), Gaps = 21/139 (15%)

Query: 376 LVLANI-AESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL 434
           L LAN+ ++ +    TC A N  G+    V + V+        P   QL      +  C+
Sbjct: 249 LTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSF-------PASVQLHTAVEMHHWCI 301

Query: 435 ---TQATPKPTVVWYRNQMLISEDSRF----------EVFKNGTLRINSVEVYDGTWYRC 481
                  P P++ W  N  +++E S            E  ++G LR+N     +   Y  
Sbjct: 302 PFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTL 361

Query: 482 MSSTPAGSIEAQARVQVLD 500
           +++ P G   A      +D
Sbjct: 362 LAANPFGQASASIMAAFMD 380


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
            precursor [Homo sapiens]
          Length = 825

 Score =  221 bits (563), Expect = 3e-57
 Identities = 170/569 (29%), Positives = 268/569 (47%), Gaps = 61/569 (10%)

Query: 507  WVTDNAGTLHFARVTRDDAG-NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQ 565
            W   +A  L    VT +D G   TCIA N   G   A V LTV         P   ++ +
Sbjct: 260  WTNVHAINLTLVNVTSEDNGFTLTCIAEN-VVGMSNASVALTVYY------PPRVVSLEE 312

Query: 566  GHTALLQC---EAQGDPKPLIQWKGKDRILDPTKLGPRMHI-------FQNGSLVIHDVA 615
                L  C     +G+P P + W    + L  +K+   +H+          G L+ +   
Sbjct: 313  PELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKI---IHVEYYQEGEISEGCLLFNKPT 369

Query: 616  PEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEG-----PGSPPPYKMI------QT 664
              ++G YT IA N     +     + + +P PE ++        SP P   +       T
Sbjct: 370  HYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDT 429

Query: 665  IGLSVG---AAVAYIIAVLGLMFYCKKRCKAKRLQKQP----EGEEPEMECLNGGPLQNG 717
             G+S+    AA A ++ V+  +   K   ++K   K P     GEE     L+       
Sbjct: 430  FGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGIT 489

Query: 718  QPSA-EIQEEVALTSLGSGPAATNKRH-STSDKMHFPRSSLQPITT--------LGKSEF 767
             PS+ +   +  +  +   P   N ++       H P + +Q I          LG+  F
Sbjct: 490  TPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAF 549

Query: 768  GEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCRE 827
            G+VFLA+   L     + LV VK+L+      + DF+RE E+   L H ++V+  G+C +
Sbjct: 550  GKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGD 609

Query: 828  AEPHYMVLEYVDLGDLKQFLR-------ISKSKDEKLKSQPLSTKQKVALCTQVALGMEH 880
             +P  MV EY+  GDL +FLR       I      +     L   Q + + +Q+A GM +
Sbjct: 610  GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVY 669

Query: 881  LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPLRWMSPEAIL 939
            L++  FVH+DLA RNCLV A   VK+   G+S+DVY+++YY       +P+RWM PE+I+
Sbjct: 670  LASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM 729

Query: 940  EGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRL 999
               F+T+SDVW+FGV++WE+FT+G+ P    ++ EV+  +  G+  L +P  CP ++Y +
Sbjct: 730  YRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRV-LERPRVCPKEVYDV 788

Query: 1000 MQRCWALSPKDRPSFSE---IASALGDST 1025
            M  CW   P+ R +  E   I  ALG +T
Sbjct: 789  MLGCWQREPQQRLNIKEIYKILHALGKAT 817



 Score = 38.9 bits (89), Expect = 0.025
 Identities = 48/187 (25%), Positives = 68/187 (36%), Gaps = 28/187 (14%)

Query: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389
           G    +TC    G P P V W   G++ + TH     +   H   L L N+   D G   
Sbjct: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282

Query: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446
           TC A N+ G     V +TV         P+   LEE +     C+    +  P PT+ W 
Sbjct: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336

Query: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVL 499
            N   + E     V          G L  N    Y+   Y  ++  P G+       Q +
Sbjct: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTAN-----QTI 391

Query: 500 DGSSLPE 506
           +G  L E
Sbjct: 392 NGHFLKE 398



 Score = 34.3 bits (77), Expect = 0.62
 Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)

Query: 527 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 585
           N  CI ++G Q  +   + ++        V     TV +G  A++ C   G P P + W 
Sbjct: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244

Query: 586 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 641
             G   I    T L    +H     +L + +V  ED+G   TCIA N   + +    L V
Sbjct: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301

Query: 642 VDKPVPEESEGP-------------GSPPP 658
              P     E P             G+PPP
Sbjct: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331



 Score = 33.9 bits (76), Expect = 0.81
 Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)

Query: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
           F ++I+      + ++  ++ V   + A+  C  S  P P + W+      I   +   +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
           L    V A    L+      N     CI +   G        +  A +     + PRV +
Sbjct: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309

Query: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
               E     C+    +G P P++ W H G  L      H   YQ+G      L+     
Sbjct: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369

Query: 383 ESDAGVYTCHAANLAGQRRQDVN 405
             + G YT  A N  G   Q +N
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTIN 392



 Score = 31.6 bits (70), Expect = 4.0
 Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)

Query: 45  QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
           +G  A++ C         V W++ G        T   +    +++   V+   +D+G T 
Sbjct: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282

Query: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
            C+A ++V G     +NAS  +  +   P V+     E  ++   +  +R    G+P PT
Sbjct: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332

Query: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
             W  +G PL + +  H    +E  ++   L    P H  +G Y+  A +  G A  + N
Sbjct: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392


>gi|222144233 fibroblast growth factor receptor 2 isoform 4 precursor
            [Homo sapiens]
          Length = 709

 Score =  221 bits (562), Expect = 4e-57
 Identities = 144/500 (28%), Positives = 243/500 (48%), Gaps = 44/500 (8%)

Query: 553  TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 611
            T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 159  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 218

Query: 612  HDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVG 670
              V P D G YTC+  N   +I HT    Y +D   P   +   + P Y  I    + V 
Sbjct: 219  ESVVPSDKGNYTCVVENEYGSINHT----YHLDVVAPGREKEITASPDYLEIAIYCIGVF 274

Query: 671  AAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVAL 729
                 ++ V+         C+ K   K+P+   +P +  L        Q +   +   ++
Sbjct: 275  LIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSM 326

Query: 730  TSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLA 773
             S       T +  ST+D                K  FPR  L     LG+  FG+V +A
Sbjct: 327  NSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMA 386

Query: 774  KAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAE 829
            +A G+++   +  V V     KD+  + D      E+EM   +  H N++ LLG C +  
Sbjct: 387  EAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDG 446

Query: 830  PHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLS 882
            P Y+++EY   G+L+++LR  +           ++  + ++ K  V+   Q+A GME+L+
Sbjct: 447  PLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLA 506

Query: 883  NNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEG 941
            + + +H+DLAARN LV+    +K++  GL++D+ N +YY       +P++WM+PEA+ + 
Sbjct: 507  SQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR 566

Query: 942  DFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQ 1001
             ++ +SDVW+FGVLMWE+FT G  P+ G   +E+   L+ G  R+ +P  C ++LY +M+
Sbjct: 567  VYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMR 625

Query: 1002 RCWALSPKDRPSFSEIASAL 1021
             CW   P  RP+F ++   L
Sbjct: 626  DCWHAVPSQRPTFKQLVEDL 645



 Score = 38.5 bits (88), Expect = 0.033
 Identities = 43/202 (21%), Positives = 66/202 (32%), Gaps = 36/202 (17%)

Query: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100

Query: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160

Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216

Query: 186 TLRPAGPEHSGLYSCCAHSAFG 207
            +    P   G Y+C   + +G
Sbjct: 217 IMESVVPSDKGNYTCVVENEYG 238



 Score = 34.7 bits (78), Expect = 0.48
 Identities = 58/251 (23%), Positives = 91/251 (36%), Gaps = 67/251 (26%)

Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95

Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
                     SL++  V P + G Y C+ + + G    +  T HL            V  
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHL-----------DVVA 250

Query: 335 AGSEERVTCLP 345
            G E+ +T  P
Sbjct: 251 PGREKEITASP 261



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 45/216 (20%), Positives = 75/216 (34%), Gaps = 36/216 (16%)

Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
           +P V+ A  G    V CL    L + +V  W   GV L  + R    G  L +      D
Sbjct: 46  QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101

Query: 386 AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
           +G+Y C A+           + V    S          E+   G  D +++ +      +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAIS------SGDDEDDTDGAEDFVSENSNNKRAPY 155

Query: 446 YRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
           + N   + +            R+++V   +   +RC    PAG         + +G    
Sbjct: 156 WTNTEKMEK------------RLHAVPAANTVKFRC----PAGGNPMPTMRWLKNGKEFK 199

Query: 506 E-------WVTDNAGTLHFARVTRDDAGNYTCIASN 534
           +        V +   +L    V   D GNYTC+  N
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN 235


>gi|222144241 fibroblast growth factor receptor 2 isoform 8 precursor
            [Homo sapiens]
          Length = 704

 Score =  220 bits (561), Expect = 5e-57
 Identities = 162/549 (29%), Positives = 260/549 (47%), Gaps = 61/549 (11%)

Query: 520  VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 573
            V   D GNYTC+  N   G I     L V         +   +    +TV  G    + C
Sbjct: 106  VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 163

Query: 574  EAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDS 619
            +   D +P IQW  K    + +K GP     + + +             L I +V  ED+
Sbjct: 164  KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA 222

Query: 620  GRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAV 679
            G YTC+AGNS  I    A L V+  P P   +   + P Y  I    + V      ++ V
Sbjct: 223  GEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTV 280

Query: 680  LGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEE-------VALTS 731
            +         C+ K   K+P+   +P +  L        Q SAE           V +T+
Sbjct: 281  I--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITT 332

Query: 732  LGSGPAATNKRHSTSD-------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAE 784
              S  A T      S+       K  FPR  L     LG+  FG+V +A+A G+++   +
Sbjct: 333  RLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPK 392

Query: 785  TLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDL 840
              V V     KD+  + D      E+EM   +  H N++ LLG C +  P Y+++EY   
Sbjct: 393  EAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK 452

Query: 841  GDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAA 893
            G+L+++LR  +           ++  + ++ K  V+   Q+A GME+L++ + +H+DLAA
Sbjct: 453  GNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAA 512

Query: 894  RNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVWAF 952
            RN LV+    +K++  GL++D+ N +YY       +P++WM+PEA+ +  ++ +SDVW+F
Sbjct: 513  RNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 572

Query: 953  GVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRP 1012
            GVLMWE+FT G  P+ G   +E+   L+ G  R+ +P  C ++LY +M+ CW   P  RP
Sbjct: 573  GVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQRP 631

Query: 1013 SFSEIASAL 1021
            +F ++   L
Sbjct: 632  TFKQLVEDL 640



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 611
           T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 44  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 103

Query: 612 HDVAPEDSGRYTCIAGNSC-NIKHT 635
             V P D G YTC+  N   +I HT
Sbjct: 104 ESVVPSDKGNYTCVVENEYGSINHT 128



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W ++G           + V ++  +L +    P   G Y+C   
Sbjct: 60  VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 119

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +       +  F C+  +   P +QW+
Sbjct: 120 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 176


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c
            precursor [Homo sapiens]
          Length = 822

 Score =  220 bits (560), Expect = 6e-57
 Identities = 167/571 (29%), Positives = 266/571 (46%), Gaps = 73/571 (12%)

Query: 513  GTLHFARVTRDDAGNY-TCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTA 569
            G+L    ++ DD+G   +C+A N   G+ +  V LTV  A  ITF   P        H  
Sbjct: 248  GSLRITNISSDDSGKQISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHW 301

Query: 570  LLQCEAQGDPKPLIQWKGKDRILDP-----TKLGPRMHIFQNGSLVIHDVAPEDSGRYTC 624
             +    +G+PKP +QW     IL+      TK+    H   +G L + +    ++G YT 
Sbjct: 302  CIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTL 361

Query: 625  IAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPP-YKMIQTIGLSVGA------------ 671
            IA N       +   + +  P  ++   P  P   Y+   T    +G             
Sbjct: 362  IAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTD 421

Query: 672  -------------AVAYIIAVLG-----LMFYCKKRCKAKRLQKQP--------EGEEPE 705
                         AV  I +V+G     ++F  K    +K   K P        +   P 
Sbjct: 422  VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPL 481

Query: 706  MECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHS--TSDKM-------HFPRSSL 756
                NG    N   S+E   +  +  +   P   N ++   T+ ++       H  R ++
Sbjct: 482  HHISNGS---NTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNI 538

Query: 757  QPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHA 816
                 LG+  FG+VFLA+   L     + LV VK+L+   +  + DF RE E+   L H 
Sbjct: 539  VLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHE 598

Query: 817  NVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ-----PLSTKQKVALC 871
            ++V+  G+C E +P  MV EY+  GDL +FLR +   D  L ++      L+  Q + + 
Sbjct: 599  HIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAVLMAEGNPPTELTQSQMLHIA 657

Query: 872  TQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF-RQAWVPL 930
             Q+A GM +L++  FVH+DLA RNCLV     VK+   G+S+DVY+++YY       +P+
Sbjct: 658  QQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 717

Query: 931  RWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE 990
            RWM PE+I+   F+T+SDVW+ GV++WE+FT+G+ P    +++EV+  +  G+  L +P 
Sbjct: 718  RWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV-LQRPR 776

Query: 991  GCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
             CP ++Y LM  CW   P  R +   I + L
Sbjct: 777  TCPQEVYELMLGCWQREPHMRKNIKGIHTLL 807



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 8/110 (7%)

Query: 348 GLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVY-TCHAANLAGQRRQDVNI 406
           G P P+++W+   +              L + NI+  D+G   +C A NL G+ +  VN+
Sbjct: 222 GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNL 281

Query: 407 TVATVPS--WLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISE 454
           TV   P+  +L+ P            +    +  PKP + W+ N  +++E
Sbjct: 282 TVHFAPTITFLESPTSDH-----HWCIPFTVKGNPKPALQWFYNGAILNE 326



 Score = 37.4 bits (85), Expect = 0.073
 Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)

Query: 45  QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
           +G+   L C V      ++YW +     +          SL    +          CVA 
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268

Query: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
           +++ GE+  S N +     +   P +  L+ P S+          +   + G+P+P  QW
Sbjct: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317

Query: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
           F +G  L++ +      H  +  E +  L+   P H  +G Y+  A + +G+
Sbjct: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369



 Score = 33.9 bits (76), Expect = 0.81
 Identities = 28/95 (29%), Positives = 40/95 (42%), Gaps = 5/95 (5%)

Query: 562 TVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGR 621
           TV +G +  L C   GDP P + W   +  L    +    H    GSL I +++ +DSG+
Sbjct: 207 TVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSH--TQGSLRITNISSDDSGK 262

Query: 622 -YTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGS 655
             +C+A N          L V   P     E P S
Sbjct: 263 QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS 297



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)

Query: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
           A    ++    +TL C + G P P   W  D   L     N T S  + +L +     + 
Sbjct: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259

Query: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
           SG   SC A +  G+   S N T+      FA  +   +      +    F       P 
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312

Query: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
           P+LQW +     I N S+      H+   T + +G L L      N G Y  I + + G
Sbjct: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368


>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
            [Homo sapiens]
          Length = 808

 Score =  219 bits (559), Expect = 8e-57
 Identities = 201/753 (26%), Positives = 311/753 (41%), Gaps = 109/753 (14%)

Query: 329  EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
            E  VF +G    ++C PP G P     W   G  L    RV      L + N +  D+G 
Sbjct: 47   EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106

Query: 389  YTCHAANLAGQRRQDVNITVATVPS------WLKKPQDSQLEEGKPGY-----LDCLTQA 437
            Y+C    L  +     ++ V   PS         + +D+ ++ G P +     +D    A
Sbjct: 107  YSCRQ-RLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLA 165

Query: 438  TPKPTVVWYRNQMLISEDSRFEVFKNGTL-----RINSVEVYDGTWYRCMSSTPAGSIEA 492
             P    V +R     +        KNG       RI  +++    W   M S        
Sbjct: 166  VPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMES-------- 217

Query: 493  QARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFI 552
                                       V   D GNYTC+  N   G IR    L V    
Sbjct: 218  ---------------------------VVPSDRGNYTCVVEN-KFGSIRQTYTLDVLERS 249

Query: 553  TFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGP-------- 599
              +       P   T   G      C+   D +P IQW  K   ++ +K+GP        
Sbjct: 250  PHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL-KHVEVNGSKVGPDGTPYVTV 308

Query: 600  -----RMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEES--EG 652
                    +  +  L + +V+  D G Y C A N   +      L V      EE   E 
Sbjct: 309  LKSWISESVEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEA 368

Query: 653  PGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKR---------LQKQPEGEE 703
              +   Y  I    LS G      I V+  +  C+ R   K+         + + P   +
Sbjct: 369  DEAGSVYAGI----LSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQ 424

Query: 704  PEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRH---STSDKMHFPRSSLQPIT 760
              +E  +   + +  P   I    A  S G GP   N          K    R+ L    
Sbjct: 425  VSLE--SNASMSSNTPLVRI----ARLSSGEGPTLANVSELELPADPKWELSRARLTLGK 478

Query: 761  TLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HA 816
             LG+  FG+V +A+A G+++  A   V V     KD+    D      E+EM   +  H 
Sbjct: 479  PLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHK 538

Query: 817  NVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDE-KLKSQPLSTKQKVA 869
            N++ LLG C +  P Y+++EY   G+L++FLR  +      S D  K   + L+ K  V+
Sbjct: 539  NIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVS 598

Query: 870  LCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYY-HFRQAWV 928
               QVA GME+L++ + +H+DLAARN LV+    +K++  GL++DV+N +YY       +
Sbjct: 599  CAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRL 658

Query: 929  PLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQ 988
            P++WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G  P+ G   +E+   L+ G  R+ +
Sbjct: 659  PVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDK 717

Query: 989  PEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
            P  C   LY +M+ CW  +P  RP+F ++   L
Sbjct: 718  PANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 750



 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 68/312 (21%), Positives = 109/312 (34%), Gaps = 62/312 (19%)

Query: 37  QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
           +P  Q+ L    G    L C     GP+    W+ DG  +  +ER       L       
Sbjct: 42  EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101

Query: 93  LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
            +DSG + C  R                    DD  GE+            ++ G     
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154

Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
            P    +    +     V  RC   G+P P+  W ++G    + +  H +       ++ 
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211

Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
           +L +    P   G Y+C   + FG     Q +TL + + S  R +L    P +       
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269

Query: 241 EAMFHCQFSAQPPPSLQWLFEDETPITNRSR-----PPHLR------RATVFANGSLLLT 289
           +  FHC+  +   P +QWL   E    N S+      P++         +V A+  L L 
Sbjct: 270 DVEFHCKVYSDAQPHIQWLKHVE---VNGSKVGPDGTPYVTVLKSWISESVEADVRLRLA 326

Query: 290 QVRPRNAGIYRC 301
            V  R+ G Y C
Sbjct: 327 NVSERDGGEYLC 338



 Score = 38.5 bits (88), Expect = 0.033
 Identities = 66/293 (22%), Positives = 97/293 (33%), Gaps = 61/293 (20%)

Query: 154 GHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQ 213
           G P     W +DGT L   +    V    + L +  A  E SG YSC         C   
Sbjct: 66  GGPMGPTVWVKDGTGLVPSER---VLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLC--- 119

Query: 214 NFTLSIAD-------------------ESFARVVLAPQDV-----VVARYEEAMFHCQFS 249
           +F++ + D                   ++ A     P+ +      V       F C  +
Sbjct: 120 HFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAA 179

Query: 250 AQPPPSLQWLFED-ETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
             P PS+ WL    E    +R     LR        SL++  V P + G Y C+ + + G
Sbjct: 180 GNPTPSISWLKNGREFRGEHRIGGIKLRHQ----QWSLVMESVVPSDRGNYTCVVENKFG 235

Query: 309 PPIILEATLHLAEIEDMP--------LFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHA- 359
               +  T  L  +E  P        L   +    GS+    C           W +H  
Sbjct: 236 S---IRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVE 292

Query: 360 --GVRLPTHGRVY------------QKGHELVLANIAESDAGVYTCHAANLAG 398
             G ++   G  Y            +    L LAN++E D G Y C A N  G
Sbjct: 293 VNGSKVGPDGTPYVTVLKSWISESVEADVRLRLANVSERDGGEYLCRATNFIG 345


>gi|222144237 fibroblast growth factor receptor 2 isoform 6 precursor
            [Homo sapiens]
          Length = 706

 Score =  219 bits (558), Expect = 1e-56
 Identities = 158/551 (28%), Positives = 259/551 (47%), Gaps = 63/551 (11%)

Query: 520  VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 573
            V   D GNYTC+  N   G I     L V         +   +    +TV  G    + C
Sbjct: 106  VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 163

Query: 574  EAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDS 619
            +   D +P IQW  K    + +K GP     + + +             L I +V  ED+
Sbjct: 164  KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA 222

Query: 620  GRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAV 679
            G YTC+AGNS  I    A L V+  P P   +   + P Y  I    + V      ++ V
Sbjct: 223  GEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTV 280

Query: 680  LGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAA 738
            +         C+ K   K+P+   +P +  L        Q +   +   ++ S       
Sbjct: 281  I--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 332

Query: 739  TNKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGV 782
            T +  ST+D                K  FPR  L     LG+  FG+V +A+A G+++  
Sbjct: 333  TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 392

Query: 783  AETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYV 838
             +  V V     KD+  + D      E+EM   +  H N++ LLG C +  P Y+++EY 
Sbjct: 393  PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 452

Query: 839  DLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDL 891
              G+L+++LR  +           ++  + ++ K  V+   Q+A GME+L++ + +H+DL
Sbjct: 453  SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 512

Query: 892  AARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVW 950
            AARN LV+    +K++  GL++D+ N +YY       +P++WM+PEA+ +  ++ +SDVW
Sbjct: 513  AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 572

Query: 951  AFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKD 1010
            +FGVLMWE+FT G  P+ G   +E+   L+ G  R+ +P  C ++LY +M+ CW   P  
Sbjct: 573  SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQ 631

Query: 1011 RPSFSEIASAL 1021
            RP+F ++   L
Sbjct: 632  RPTFKQLVEDL 642



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 611
           T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 44  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 103

Query: 612 HDVAPEDSGRYTCIAGNSC-NIKHT 635
             V P D G YTC+  N   +I HT
Sbjct: 104 ESVVPSDKGNYTCVVENEYGSINHT 128



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W ++G           + V ++  +L +    P   G Y+C   
Sbjct: 60  VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 119

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +       +  F C+  +   P +QW+
Sbjct: 120 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 176


>gi|222144235 fibroblast growth factor receptor 2 isoform 5 precursor
            [Homo sapiens]
          Length = 707

 Score =  219 bits (558), Expect = 1e-56
 Identities = 158/551 (28%), Positives = 259/551 (47%), Gaps = 63/551 (11%)

Query: 520  VTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FITFKVEPERTTVYQGHTALLQC 573
            V   D GNYTC+  N   G I     L V         +   +    +TV  G    + C
Sbjct: 132  VVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFV-C 189

Query: 574  EAQGDPKPLIQWKGKDRILDPTKLGPR----MHIFQNGS----------LVIHDVAPEDS 619
            +   D +P IQW  K    + +K GP     + + +             L I +V  ED+
Sbjct: 190  KVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDA 248

Query: 620  GRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAV 679
            G YTC+AGNS  I    A L V+  P P   +   + P Y  I    + V      ++ V
Sbjct: 249  GEYTCLAGNSIGISFHSAWLTVL--PAPGREKEITASPDYLEIAIYCIGVFLIACMVVTV 306

Query: 680  LGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAA 738
            +         C+ K   K+P+   +P +  L        Q +   +   ++ S       
Sbjct: 307  I--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRI 358

Query: 739  TNKRHSTSD----------------KMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGV 782
            T +  ST+D                K  FPR  L     LG+  FG+V +A+A G+++  
Sbjct: 359  TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDK 418

Query: 783  AETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYV 838
             +  V V     KD+  + D      E+EM   +  H N++ LLG C +  P Y+++EY 
Sbjct: 419  PKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 478

Query: 839  DLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDL 891
              G+L+++LR  +           ++  + ++ K  V+   Q+A GME+L++ + +H+DL
Sbjct: 479  SKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDL 538

Query: 892  AARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAILEGDFSTKSDVW 950
            AARN LV+    +K++  GL++D+ N +YY       +P++WM+PEA+ +  ++ +SDVW
Sbjct: 539  AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVW 598

Query: 951  AFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKD 1010
            +FGVLMWE+FT G  P+ G   +E+   L+ G  R+ +P  C ++LY +M+ CW   P  
Sbjct: 599  SFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMMMRDCWHAVPSQ 657

Query: 1011 RPSFSEIASAL 1021
            RP+F ++   L
Sbjct: 658  RPTFKQLVEDL 668



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 2/85 (2%)

Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 611
           T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 70  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 129

Query: 612 HDVAPEDSGRYTCIAGNSC-NIKHT 635
             V P D G YTC+  N   +I HT
Sbjct: 130 ESVVPSDKGNYTCVVENEYGSINHT 154



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 26/119 (21%), Positives = 49/119 (41%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W ++G           + V ++  +L +    P   G Y+C   
Sbjct: 86  VKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVE 145

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           + +G    +  + L + + S  R +L    P +       +  F C+  +   P +QW+
Sbjct: 146 NEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI 202


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  217 bits (553), Expect = 4e-56
 Identities = 132/398 (33%), Positives = 214/398 (53%), Gaps = 40/398 (10%)

Query: 642  VDKP-VPEESEGPGS-PPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQP 699
            VD P +P  S    S  P Y M  T+ +S+ ++ A  + +     YC   C+ ++  K  
Sbjct: 473  VDIPNLPSSSSSSFSVSPTYSM--TVIISIMSSFAIFVLLTITTLYC---CRRRKQWKNK 527

Query: 700  EGEEPEMECLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM---HFPRSSL 756
            + E   +                +  E+ L  L   P         + K+    +PR+++
Sbjct: 528  KRESAAVTLTT------------LPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNI 575

Query: 757  QPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK-DEQQQLDFRRELEMFGKLNH 815
            + +  +G+  FG VF A+A GL      T+V VK L+ +     Q DF+RE  +  + ++
Sbjct: 576  EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDN 635

Query: 816  ANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKS--------KDEKLKSQ------- 860
             N+V+LLG+C   +P  ++ EY+  GDL +FLR             D  +++Q       
Sbjct: 636  PNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPP 695

Query: 861  PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEY 920
            PLS  +++ +  QVA GM +LS  +FVH+DLA RNCLV     VK++  GLS+++Y+++Y
Sbjct: 696  PLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADY 755

Query: 921  YHFRQ-AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADL 979
            Y   +   +P+RWM PE+I    ++T+SDVWA+GV++WE+F++G  P+ G A +EV+  +
Sbjct: 756  YKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYV 815

Query: 980  QAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEI 1017
            + G   L  PE CP +LY LM+ CW+  P DRPSF+ I
Sbjct: 816  RDGNI-LSCPENCPVELYNLMRLCWSKLPADRPSFTSI 852



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 73/306 (23%), Positives = 111/306 (36%), Gaps = 83/306 (27%)

Query: 350 PEPSVWWEHAGVRLP---THGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVN- 405
           P+P + W    + +    T   + + G  L + ++ +SD G+Y C A N  G   +    
Sbjct: 55  PQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGA 114

Query: 406 ITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGT 465
           + V   P   + P + ++ EG    L C T   PKP+V W +    + E+SR  V ++G+
Sbjct: 115 LQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGS 174

Query: 466 LRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDA 525
           LRI++V+  D   YRC++    G+  ++                                
Sbjct: 175 LRIHNVQKEDAGQYRCVAKNSLGTAYSKV------------------------------- 203

Query: 526 GNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 585
                             V+L V VF      PE   V  G    L C A G P P I W
Sbjct: 204 ------------------VKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITW 245

Query: 586 --------------KGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSCN 631
                           KDR++D      R+ +F               G YTCIA N   
Sbjct: 246 IENGNAVSSGSIQESVKDRVID-----SRLQLFIT-----------KPGLYTCIATNKHG 289

Query: 632 IKHTEA 637
            K + A
Sbjct: 290 EKFSTA 295



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 65/300 (21%), Positives = 125/300 (41%), Gaps = 21/300 (7%)

Query: 130 VLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRP 189
           V+  P    +   +   T  C ++ +P+P   W R+   +    + +++    + LT+  
Sbjct: 29  VITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILS 88

Query: 190 AGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFS 249
                 G+Y C A++  G A  S     ++  +   ++   P +V +    +A+  C   
Sbjct: 89  VEDSDDGIYCCTANNGVGGAVESCG---ALQVKMKPKITRPPINVKIIEGLKAVLPCTTM 145

Query: 250 AQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGP 309
             P PS+ W+ + ++P+   S      R  V  +GSL +  V+  +AG YRC+ +   G 
Sbjct: 146 GNPKPSVSWI-KGDSPLRENS------RIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGT 198

Query: 310 PIILEATLHL---AEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTH 366
                  L +   A I   P  E    T GS   + C    G+P P++ W   G    + 
Sbjct: 199 AYSKVVKLEVEVFARILRAP--ESHNVTFGSFVTLHC-TATGIPVPTITWIENG-NAVSS 254

Query: 367 GRVYQKGHELVLANIAE---SDAGVYTCHAANLAGQRRQDVNITVA-TVPSWLKKPQDSQ 422
           G + +   + V+ +  +   +  G+YTC A N  G++          ++  W K  +D++
Sbjct: 255 GSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNK 314



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 75/300 (25%), Positives = 112/300 (37%), Gaps = 37/300 (12%)

Query: 225 ARVVLAPQDVVVARYEE-AMFHCQFSAQPPPSLQW--------LFEDETPITNRSRPPHL 275
           A V+  P + V A  EE A F C   + P P + W        LF+              
Sbjct: 27  APVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDT------------- 73

Query: 276 RRATVFANGSLL-LTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-LFEPRVF 333
            R ++  NG LL +  V   + GIY C      G  +     L   +++  P +  P + 
Sbjct: 74  -RYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGAL---QVKMKPKITRPPIN 129

Query: 334 TAGSEERVTCLP--PKGLPEPSVWWEHAGVRLPTHGRV-YQKGHELVLANIAESDAGVYT 390
               E     LP    G P+PSV W      L  + R+   +   L + N+ + DAG Y 
Sbjct: 130 VKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYR 189

Query: 391 CHAANLAGQRRQDV-NITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQ 449
           C A N  G     V  + V      L+ P+   +  G    L C     P PT+ W  N 
Sbjct: 190 CVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENG 249

Query: 450 MLISEDSRFEVFKNGTL--RINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLPEW 507
             +S  S  E  K+  +  R+       G  Y C+++   G   + A+       S+ EW
Sbjct: 250 NAVSSGSIQESVKDRVIDSRLQLFITKPGL-YTCIATNKHGEKFSTAKAAAT--ISIAEW 306



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 49/193 (25%), Positives = 87/193 (45%), Gaps = 15/193 (7%)

Query: 36  KQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTER-RFAQGSSLSFAAVDRLQ 94
           + P +   ++G +A+L C         V W+   +P+++  R    +  SL    V + +
Sbjct: 125 RPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQK-E 183

Query: 95  DSGTFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDG 154
           D+G ++CVA++ +    ++          +E    +L+ P S   +   + VTL C   G
Sbjct: 184 DAGQYRCVAKNSLGTAYSKVVKLE-----VEVFARILRAPESH-NVTFGSFVTLHCTATG 237

Query: 155 HPRPTYQWFRDGTPLSDGQSNHTVSSK--ERNLTLRPAGPEHSGLYSCCAHSAFGQACSS 212
            P PT  W  +G  +S G    +V  +  +  L L    P   GLY+C A +  G+  S+
Sbjct: 238 IPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKP---GLYTCIATNKHGEKFST 294

Query: 213 QN--FTLSIADES 223
                T+SIA+ S
Sbjct: 295 AKAAATISIAEWS 307


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
            [Homo sapiens]
          Length = 762

 Score =  217 bits (552), Expect = 5e-56
 Identities = 210/756 (27%), Positives = 330/756 (43%), Gaps = 110/756 (14%)

Query: 308  GPPII-LEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPK----GLPEPSVWWEHAGVR 362
            GPP++ LEA+    E+E  P   P +     E  V    P     G  E    W   G R
Sbjct: 16   GPPVLSLEAS---EEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSR 72

Query: 363  LPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQ 422
            L   GRV      L +A+    DAG Y C A    G      N+T+ T  S      D  
Sbjct: 73   LAPAGRVRGWRGRLEIASFLPEDAGRYLCLAR---GSMIVLQNLTLITGDSLTSSNDD-- 127

Query: 423  LEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCM 482
             E+ K         + P+    W   Q +               ++++V   +   +RC 
Sbjct: 128  -EDPKSHRDPSNRHSYPQQAPYWTHPQRMEK-------------KLHAVPAGNTVKFRCP 173

Query: 483  SS-TPAGSIEAQARVQVLDGSSLPEWVT--DNAGTLHFARVTRDDAGNYTCIASNGPQGQ 539
            ++  P  +I      Q   G +    +       +L    V   D G YTC+  N   G 
Sbjct: 174  AAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAV-GS 232

Query: 540  IRAHVQLTVAVFITFKVE-----PERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDP 594
            IR +  L V      +       P  TT   G    L C+   D +P IQW  K  +++ 
Sbjct: 233  IRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL-KHIVING 291

Query: 595  TKLG----PRMHIFQNGS--------LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVV 642
            +  G    P + + +           L + +V+ ED+G YTC+AGNS  + +  A L V+
Sbjct: 292  SSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL 351

Query: 643  DKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPEGE 702
                     G G  P                            C     A R +      
Sbjct: 352  P--------GTGRIPHLT-------------------------CDSLTPAGRTKS----- 373

Query: 703  EPEME-CLNGGPLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSDKM----HFPRSSLQ 757
             P ++  L  G   +G+ S+ +   V L+S  SGPA      S    +     FPR  L 
Sbjct: 374  -PTLQFSLESG--SSGKSSSSLVRGVRLSS--SGPALLAGLVSLDLPLDPLWEFPRDRLV 428

Query: 758  PITTLGKSEFGEVFLAKAQGLEEGVAE--TLVLVKSLQSKDEQQQL-DFRRELEMFGKLN 814
                LG+  FG+V  A+A G++    +  + V VK L+     + L D   E+E+   + 
Sbjct: 429  LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIG 488

Query: 815  -HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK------SKDEKLKSQ-PLSTKQ 866
             H N++ LLG+C +  P Y+++E    G+L++FLR  +      S D    S+ PLS   
Sbjct: 489  RHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPV 548

Query: 867  KVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQ 925
             V+   QVA GM++L + + +H+DLAARN LV+    +K++  GL++ V++ +YY     
Sbjct: 549  LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 608

Query: 926  AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKAR 985
              +P++WM+PEA+ +  ++ +SDVW+FG+L+WE+FT G  P+ G   +E+ + L+ G  R
Sbjct: 609  GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH-R 667

Query: 986  LPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
            + +P  CP +LY LM+ CW  +P  RP+F ++  AL
Sbjct: 668  MDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 703



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 28/119 (23%), Positives = 47/119 (39%), Gaps = 7/119 (5%)

Query: 146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKER--NLTLRPAGPEHSGLYSCCAH 203
           V  RC   G+P PT +W +DG           +  + +  +L +    P   G Y+C   
Sbjct: 168 VKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVE 227

Query: 204 SAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEAMFHCQFSAQPPPSLQWL 259
           +A G      N+ L + + S  R +L    P +       +    C+  +   P +QWL
Sbjct: 228 NAVGSI--RYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWL 284


>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform a
            precursor [Homo sapiens]
          Length = 839

 Score =  216 bits (550), Expect = 9e-56
 Identities = 170/583 (29%), Positives = 268/583 (45%), Gaps = 75/583 (12%)

Query: 507  WVTDNAGTLHFARVTRDDAG-NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQ 565
            W   +A  L    VT +D G   TCIA N   G   A V LTV         P   ++ +
Sbjct: 260  WTNVHAINLTLVNVTSEDNGFTLTCIAEN-VVGMSNASVALTVYY------PPRVVSLEE 312

Query: 566  GHTALLQC---EAQGDPKPLIQWKGKDRILDPTKLGPRMHI-------FQNGSLVIHDVA 615
                L  C     +G+P P + W    + L  +K+   +H+          G L+ +   
Sbjct: 313  PELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKI---IHVEYYQEGEISEGCLLFNKPT 369

Query: 616  PEDSGRYTCIAGNSCNIKHTEAPLYVVDKPVPEESEG-----PGSPPPYKMI------QT 664
              ++G YT IA N     +     + + +P PE ++        SP P   +       T
Sbjct: 370  HYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDT 429

Query: 665  IGLSVG---AAVAYIIAVLGLMFYCKKRCKAKRLQKQP----EGEEPEMECLNGGPLQNG 717
             G+S+    AA A ++ V+  +   K   ++K   K P     GEE     L+       
Sbjct: 430  FGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGIT 489

Query: 718  QPSA-EIQEEVALTSLGSGPAATNKRH-STSDKMHFPRSSLQPITT--------LGKSEF 767
             PS+ +   +  +  +   P   N ++       H P + +Q I          LG+  F
Sbjct: 490  TPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAF 549

Query: 768  GEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNHANVVRLLGLCRE 827
            G+VFLA+   L     + LV VK+L+      + DF+RE E+   L H ++V+  G+C +
Sbjct: 550  GKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGD 609

Query: 828  AEPHYMVLEYVDLGDLKQFLR-------ISKSKDEKLKSQPLSTKQKVALCTQVALGMEH 880
             +P  MV EY+  GDL +FLR       I      +     L   Q + + +Q+A GM +
Sbjct: 610  GDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVY 669

Query: 881  LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHF---------------RQ 925
            L++  FVH+DLA RNCLV A   VK+   G+S+DVY+++YY                   
Sbjct: 670  LASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGH 729

Query: 926  AWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKAR 985
              +P+RWM PE+I+   F+T+SDVW+FGV++WE+FT+G+ P    ++ EV+  +  G+  
Sbjct: 730  TMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRV- 788

Query: 986  LPQPEGCPSKLYRLMQRCWALSPKDRPSFSE---IASALGDST 1025
            L +P  CP ++Y +M  CW   P+ R +  E   I  ALG +T
Sbjct: 789  LERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKAT 831



 Score = 38.9 bits (89), Expect = 0.025
 Identities = 48/187 (25%), Positives = 68/187 (36%), Gaps = 28/187 (14%)

Query: 336 GSEERVTCLPPKGLPEPSVWWEHAGVR-LPTH--GRVYQKGH--ELVLANIAESDAG-VY 389
           G    +TC    G P P V W   G++ + TH     +   H   L L N+   D G   
Sbjct: 224 GDNAVITC-NGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282

Query: 390 TCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCL---TQATPKPTVVWY 446
           TC A N+ G     V +TV         P+   LEE +     C+    +  P PT+ W 
Sbjct: 283 TCIAENVVGMSNASVALTV------YYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWL 336

Query: 447 RNQMLISEDSRFEV-------FKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVL 499
            N   + E     V          G L  N    Y+   Y  ++  P G+       Q +
Sbjct: 337 HNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTAN-----QTI 391

Query: 500 DGSSLPE 506
           +G  L E
Sbjct: 392 NGHFLKE 398



 Score = 34.3 bits (77), Expect = 0.62
 Identities = 39/150 (26%), Positives = 57/150 (38%), Gaps = 22/150 (14%)

Query: 527 NYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW- 585
           N  CI ++G Q  +   + ++        V     TV +G  A++ C   G P P + W 
Sbjct: 186 NLYCINADGSQLPL-FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWI 244

Query: 586 -KGKDRI-LDPTKLG-PRMHIFQNGSLVIHDVAPEDSG-RYTCIAGNSCNIKHTEAPLYV 641
             G   I    T L    +H     +L + +V  ED+G   TCIA N   + +    L V
Sbjct: 245 VTGLQSINTHQTNLNWTNVHAI---NLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTV 301

Query: 642 VDKPVPEESEGP-------------GSPPP 658
              P     E P             G+PPP
Sbjct: 302 YYPPRVVSLEEPELRLEHCIEFVVRGNPPP 331



 Score = 33.9 bits (76), Expect = 0.81
 Identities = 44/203 (21%), Positives = 72/203 (35%), Gaps = 22/203 (10%)

Query: 215 FTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPH 274
           F ++I+      + ++  ++ V   + A+  C  S  P P + W+      I   +   +
Sbjct: 200 FRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSI--NTHQTN 257

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFT 334
           L    V A    L+      N     CI +   G        +  A +     + PRV +
Sbjct: 258 LNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVG--------MSNASVALTVYYPPRVVS 309

Query: 335 AGSEE--RVTCLP--PKGLPEPSVWWEHAGVRLP----THGRVYQKGHE----LVLANIA 382
               E     C+    +G P P++ W H G  L      H   YQ+G      L+     
Sbjct: 310 LEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPT 369

Query: 383 ESDAGVYTCHAANLAGQRRQDVN 405
             + G YT  A N  G   Q +N
Sbjct: 370 HYNNGNYTLIAKNPLGTANQTIN 392



 Score = 31.6 bits (70), Expect = 4.0
 Identities = 41/180 (22%), Positives = 75/180 (41%), Gaps = 20/180 (11%)

Query: 45  QGRRALLRCEVEAPGPVHVYWLLDGAP---VQDTERRFAQGSSLSFAAVD-RLQDSG-TF 99
           +G  A++ C         V W++ G        T   +    +++   V+   +D+G T 
Sbjct: 223 EGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTL 282

Query: 100 QCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPT 159
            C+A ++V G     +NAS  +  +   P V+     E  ++   +  +R    G+P PT
Sbjct: 283 TCIA-ENVVG----MSNASVALT-VYYPPRVVSLEEPELRLEHCIEFVVR----GNPPPT 332

Query: 160 YQWFRDGTPLSDGQSNHTVSSKERNLT---LRPAGPEH--SGLYSCCAHSAFGQACSSQN 214
             W  +G PL + +  H    +E  ++   L    P H  +G Y+  A +  G A  + N
Sbjct: 333 LHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTIN 392


>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
            [Homo sapiens]
          Length = 769

 Score =  216 bits (549), Expect = 1e-55
 Identities = 191/751 (25%), Positives = 319/751 (42%), Gaps = 96/751 (12%)

Query: 329  EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
            +P V+ A  G    V CL    L + +V  W   GV L  + R    G  L +      D
Sbjct: 46   QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101

Query: 386  AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
            +G+Y C A+           + V    S          E+   G  D +++ +      +
Sbjct: 102  SGLYACTASRTVDSETWYFMVNVTDAIS------SGDDEDDTDGAEDFVSENSNNKRAPY 155

Query: 446  YRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
            + N   + +            R+++V   +   +RC    PAG         + +G    
Sbjct: 156  WTNTEKMEK------------RLHAVPAANTVKFRC----PAGGNPMPTMRWLKNGKEFK 199

Query: 506  EW-------VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FI 552
            +        V +   +L    V   D GNYTC+  N   G I     L V         +
Sbjct: 200  QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPIL 258

Query: 553  TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR--------MHIF 604
               +    +TV  G    + C+   D +P IQW  K    + +K GP          H  
Sbjct: 259  QAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKHSG 316

Query: 605  QNGS----LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKP-VPEESEGPGSPPPY 659
             N S    L + +V   D+G Y C   N     +  A L V+ K   P   +   + P Y
Sbjct: 317  INSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDY 376

Query: 660  KMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQ 718
              I    + V      ++ V+         C+ K   K+P+   +P +  L        Q
Sbjct: 377  LEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQ 428

Query: 719  PSAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITTL 762
             +   +   ++ S       T +  ST+D                K  FPR  L     L
Sbjct: 429  VTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL 488

Query: 763  GKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANV 818
            G+  FG+V +A+A G+++   +  V V     KD+  + D      E+EM   +  H N+
Sbjct: 489  GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI 548

Query: 819  VRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALC 871
            + LLG C +  P Y+++EY   G+L+++LR  +           ++  + ++ K  V+  
Sbjct: 549  INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCT 608

Query: 872  TQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPL 930
             Q+A GME+L++ + +H+DLAARN LV+    +K++  GL++D+ N +YY       +P+
Sbjct: 609  YQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 668

Query: 931  RWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE 990
            +WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ G   +E+   L+ G  R+ +P 
Sbjct: 669  KWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPA 727

Query: 991  GCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
             C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 728  NCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 80/337 (23%), Positives = 120/337 (35%), Gaps = 80/337 (23%)

Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95

Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
                     SL++  V P + G Y C+ + + G    +  T HL  +E  P        
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261

Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQK---------- 372
           L        G +    C       +P + W    E  G +    G  Y K          
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSS 320

Query: 373 -GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
               L L N+ E+DAG Y C  +N  GQ  Q   +TV
Sbjct: 321 NAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTV 357



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)

Query: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100

Query: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160

Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216

Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
            +    P   G Y+C   + +G    +  + L + + S  R +L    P +       + 
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274

Query: 243 MFHCQFSAQPPPSLQWL 259
            F C+  +   P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291


>gi|221316638 fibroblast growth factor receptor 2 isoform 2 precursor
            [Homo sapiens]
          Length = 822

 Score =  216 bits (549), Expect = 1e-55
 Identities = 191/751 (25%), Positives = 319/751 (42%), Gaps = 96/751 (12%)

Query: 329  EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
            +P V+ A  G    V CL    L + +V  W   GV L  + R    G  L +      D
Sbjct: 46   QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101

Query: 386  AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
            +G+Y C A+           + V    S          E+   G  D +++ +      +
Sbjct: 102  SGLYACTASRTVDSETWYFMVNVTDAIS------SGDDEDDTDGAEDFVSENSNNKRAPY 155

Query: 446  YRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
            + N   + +            R+++V   +   +RC    PAG         + +G    
Sbjct: 156  WTNTEKMEK------------RLHAVPAANTVKFRC----PAGGNPMPTMRWLKNGKEFK 199

Query: 506  EW-------VTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAV------FI 552
            +        V +   +L    V   D GNYTC+  N   G I     L V         +
Sbjct: 200  QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPIL 258

Query: 553  TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPR--------MHIF 604
               +    +TV  G    + C+   D +P IQW  K    + +K GP          H  
Sbjct: 259  QAGLPANASTVVGGDVEFV-CKVYSDAQPHIQWI-KHVEKNGSKYGPDGLPYLKVLKHSG 316

Query: 605  QNGS----LVIHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVDKP-VPEESEGPGSPPPY 659
             N S    L + +V   D+G Y C   N     +  A L V+ K   P   +   + P Y
Sbjct: 317  INSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREKEITASPDY 376

Query: 660  KMIQTIGLSVGAAVAYIIAVLGLMFYCKKRCKAKRLQKQPE-GEEPEMECLNGGPLQNGQ 718
              I    + V      ++ V+         C+ K   K+P+   +P +  L        Q
Sbjct: 377  LEIAIYCIGVFLIACMVVTVI--------LCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQ 428

Query: 719  PSAEIQEEVALTSLGSGPAATNKRHSTSD----------------KMHFPRSSLQPITTL 762
             +   +   ++ S       T +  ST+D                K  FPR  L     L
Sbjct: 429  VTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL 488

Query: 763  GKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANV 818
            G+  FG+V +A+A G+++   +  V V     KD+  + D      E+EM   +  H N+
Sbjct: 489  GEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNI 548

Query: 819  VRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALC 871
            + LLG C +  P Y+++EY   G+L+++LR  +           ++  + ++ K  V+  
Sbjct: 549  INLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCT 608

Query: 872  TQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPL 930
             Q+A GME+L++ + +H+DLAARN LV+    +K++  GL++D+ N +YY       +P+
Sbjct: 609  YQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPV 668

Query: 931  RWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPE 990
            +WM+PEA+ +  ++ +SDVW+FGVLMWE+FT G  P+ G   +E+   L+ G  R+ +P 
Sbjct: 669  KWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPA 727

Query: 991  GCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
             C ++LY +M+ CW   P  RP+F ++   L
Sbjct: 728  NCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 80/337 (23%), Positives = 120/337 (35%), Gaps = 80/337 (23%)

Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95

Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP-------- 326
                     SL++  V P + G Y C+ + + G    +  T HL  +E  P        
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSPHRPILQAG 261

Query: 327 LFEPRVFTAGSEERVTCLPPKGLPEPSVWW----EHAGVRLPTHGRVYQK---------- 372
           L        G +    C       +P + W    E  G +    G  Y K          
Sbjct: 262 LPANASTVVGGDVEFVCKVYSD-AQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSS 320

Query: 373 -GHELVLANIAESDAGVYTCHAANLAGQRRQDVNITV 408
               L L N+ E+DAG Y C  +N  GQ  Q   +TV
Sbjct: 321 NAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTV 357



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)

Query: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100

Query: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160

Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216

Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
            +    P   G Y+C   + +G    +  + L + + S  R +L    P +       + 
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274

Query: 243 MFHCQFSAQPPPSLQWL 259
            F C+  +   P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291


>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a
            precursor [Homo sapiens]
          Length = 838

 Score =  214 bits (545), Expect = 3e-55
 Identities = 167/584 (28%), Positives = 267/584 (45%), Gaps = 83/584 (14%)

Query: 513  GTLHFARVTRDDAGNY-TCIASNGPQGQIRAHVQLTV--AVFITFKVEPERTTVYQGHTA 569
            G+L    ++ DD+G   +C+A N   G+ +  V LTV  A  ITF   P        H  
Sbjct: 248  GSLRITNISSDDSGKQISCVAEN-LVGEDQDSVNLTVHFAPTITFLESPT-----SDHHW 301

Query: 570  LLQCEAQGDPKPLIQWKGKDRILDP-----TKLGPRMHIFQNGSLVIHDVAPEDSGRYTC 624
             +    +G+PKP +QW     IL+      TK+    H   +G L + +    ++G YT 
Sbjct: 302  CIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTL 361

Query: 625  IAGNSCNIKHTEAPLYVVDKPVPEESEGPGSPPP-YKMIQTIGLSVGA------------ 671
            IA N       +   + +  P  ++   P  P   Y+   T    +G             
Sbjct: 362  IAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTD 421

Query: 672  -------------AVAYIIAVLG----LMFYCKKRCKAKRLQ------------KQPEGE 702
                         AV  I +V+G    +M +  K  +  +              K  +G 
Sbjct: 422  VTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGV 481

Query: 703  EPEMECLN----GGPLQ------NGQPSAEIQEEVALTSLGSGPAATNKRHS--TSDKM- 749
             P     N      PL       N   S+E   +  +  +   P   N ++   T+ ++ 
Sbjct: 482  GPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLK 541

Query: 750  ------HFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDF 803
                  H  R ++     LG+  FG+VFLA+   L     + LV VK+L+   +  + DF
Sbjct: 542  PDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDF 601

Query: 804  RRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQ--- 860
             RE E+   L H ++V+  G+C E +P  MV EY+  GDL +FLR +   D  L ++   
Sbjct: 602  HREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLR-AHGPDAVLMAEGNP 660

Query: 861  --PLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNS 918
               L+  Q + +  Q+A GM +L++  FVH+DLA RNCLV     VK+   G+S+DVY++
Sbjct: 661  PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 720

Query: 919  EYYHF-RQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLA 977
            +YY       +P+RWM PE+I+   F+T+SDVW+ GV++WE+FT+G+ P    +++EV+ 
Sbjct: 721  DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 780

Query: 978  DLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
             +  G+  L +P  CP ++Y LM  CW   P  R +   I + L
Sbjct: 781  CITQGRV-LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL 823



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 27/110 (24%), Positives = 49/110 (44%), Gaps = 8/110 (7%)

Query: 348 GLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGVY-TCHAANLAGQRRQDVNI 406
           G P P+++W+   +              L + NI+  D+G   +C A NL G+ +  VN+
Sbjct: 222 GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNL 281

Query: 407 TVATVPS--WLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISE 454
           TV   P+  +L+ P            +    +  PKP + W+ N  +++E
Sbjct: 282 TVHFAPTITFLESPTSDH-----HWCIPFTVKGNPKPALQWFYNGAILNE 326



 Score = 37.4 bits (85), Expect = 0.073
 Identities = 36/172 (20%), Positives = 68/172 (39%), Gaps = 20/172 (11%)

Query: 45  QGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQDSGTFQCVAR 104
           +G+   L C V      ++YW +     +          SL    +          CVA 
Sbjct: 210 EGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVA- 268

Query: 105 DDVTGEEARSANASFNIKWIEAGPVV--LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQW 162
           +++ GE+  S N +     +   P +  L+ P S+          +   + G+P+P  QW
Sbjct: 269 ENLVGEDQDSVNLT-----VHFAPTITFLESPTSDHHW------CIPFTVKGNPKPALQW 317

Query: 163 FRDGTPLSDGQ----SNHTVSSKERNLTLRPAGPEH--SGLYSCCAHSAFGQ 208
           F +G  L++ +      H  +  E +  L+   P H  +G Y+  A + +G+
Sbjct: 318 FYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGK 369



 Score = 33.9 bits (76), Expect = 0.81
 Identities = 28/95 (29%), Positives = 40/95 (42%), Gaps = 5/95 (5%)

Query: 562 TVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGR 621
           TV +G +  L C   GDP P + W   +  L    +    H    GSL I +++ +DSG+
Sbjct: 207 TVEEGKSITLSCSVAGDPVPNMYWDVGN--LVSKHMNETSH--TQGSLRITNISSDDSGK 262

Query: 622 -YTCIAGNSCNIKHTEAPLYVVDKPVPEESEGPGS 655
             +C+A N          L V   P     E P S
Sbjct: 263 QISCVAENLVGEDQDSVNLTVHFAPTITFLESPTS 297



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 44/179 (24%), Positives = 66/179 (36%), Gaps = 18/179 (10%)

Query: 135 ASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEH 194
           A    ++    +TL C + G P P   W  D   L     N T S  + +L +     + 
Sbjct: 203 APNLTVEEGKSITLSCSVAGDPVPNMYW--DVGNLVSKHMNET-SHTQGSLRITNISSDD 259

Query: 195 SG-LYSCCAHSAFGQACSSQNFTLSIADESFARVVLAPQDVVVARYEEAMFHCQFSAQPP 253
           SG   SC A +  G+   S N T+      FA  +   +      +    F       P 
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTV-----HFAPTITFLESPTSDHHWCIPF--TVKGNPK 312

Query: 254 PSLQWLFEDETPITNRSR----PPHLRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRG 308
           P+LQW +     I N S+      H+   T + +G L L      N G Y  I + + G
Sbjct: 313 PALQWFYNG--AILNESKYICTKIHVTNHTEY-HGCLQLDNPTHMNNGDYTLIAKNEYG 368


>gi|222144239 fibroblast growth factor receptor 2 isoform 7 precursor
            [Homo sapiens]
          Length = 705

 Score =  212 bits (540), Expect = 1e-54
 Identities = 148/502 (29%), Positives = 247/502 (49%), Gaps = 52/502 (10%)

Query: 553  TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVI 611
            T K+E     V   +T   +C A G+P P ++W K         ++G      Q+ SL++
Sbjct: 159  TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIM 218

Query: 612  HDVAPEDSGRYTCIAGNSC-NIKHTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVG 670
              V P D G YTC+  N   +I HT    Y +D  V E S       P++ I   GL   
Sbjct: 219  ESVVPSDKGNYTCVVENEYGSINHT----YHLD--VVERS-------PHRPILQAGLPAN 265

Query: 671  AAVAYIIAVLG--LMFYCKKRCKA-------KRLQKQPEGEEPE---------MECLNGG 712
            A+      V+G  + F CK    A       K ++K      P+         +   +  
Sbjct: 266  AST-----VVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKVSAESSS 320

Query: 713  PLQNGQPSAEIQEEVALTSLGSGPAATNKRHSTSD-KMHFPRSSLQPITTLGKSEFGEVF 771
             + +  P   I   ++ T+     A  ++     D K  FPR  L     LG+  FG+V 
Sbjct: 321  SMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVV 380

Query: 772  LAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFR---RELEMFGKLN-HANVVRLLGLCRE 827
            +A+A G+++   +  V V     KD+  + D      E+EM   +  H N++ LLG C +
Sbjct: 381  MAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ 440

Query: 828  AEPHYMVLEYVDLGDLKQFLRISKSKD-------EKLKSQPLSTKQKVALCTQVALGMEH 880
              P Y+++EY   G+L+++LR  +           ++  + ++ K  V+   Q+A GME+
Sbjct: 441  DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEY 500

Query: 881  LSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYH-FRQAWVPLRWMSPEAIL 939
            L++ + +H+DLAARN LV+    +K++  GL++D+ N +YY       +P++WM+PEA+ 
Sbjct: 501  LASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALF 560

Query: 940  EGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRL 999
            +  ++ +SDVW+FGVLMWE+FT G  P+ G   +E+   L+ G  R+ +P  C ++LY +
Sbjct: 561  DRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH-RMDKPANCTNELYMM 619

Query: 1000 MQRCWALSPKDRPSFSEIASAL 1021
            M+ CW   P  RP+F ++   L
Sbjct: 620  MRDCWHAVPSQRPTFKQLVEDL 641



 Score = 47.0 bits (110), Expect = 9e-05
 Identities = 53/257 (20%), Positives = 87/257 (33%), Gaps = 41/257 (15%)

Query: 35  IKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERRFAQGSSLSFAAVDRLQ 94
           I QP    A  G    +RC ++    +   W  DG  +    R    G  L        +
Sbjct: 44  ISQPEVYVAAPGESLEVRCLLKDAAVIS--WTKDGVHLGPNNRTVLIGEYLQIKGATP-R 100

Query: 95  DSGTFQCVA------------------------RDDVTGEEARSANASFNIK---WIEAG 127
           DSG + C A                         DD  G E   +  S N +   W    
Sbjct: 101 DSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTE 160

Query: 128 PVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQ--SNHTVSSKERNL 185
            +  +  A  A       V  RC   G+P PT +W ++G           + V ++  +L
Sbjct: 161 KMEKRLHAVPAA----NTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSL 216

Query: 186 TLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYEEA 242
            +    P   G Y+C   + +G    +  + L + + S  R +L    P +       + 
Sbjct: 217 IMESVVPSDKGNYTCVVENEYGSI--NHTYHLDVVERSPHRPILQAGLPANASTVVGGDV 274

Query: 243 MFHCQFSAQPPPSLQWL 259
            F C+  +   P +QW+
Sbjct: 275 EFVCKVYSDAQPHIQWI 291



 Score = 37.4 bits (85), Expect = 0.073
 Identities = 58/273 (21%), Positives = 94/273 (34%), Gaps = 44/273 (16%)

Query: 329 EPRVFTA--GSEERVTCLPPKGLPEPSVW-WEHAGVRLPTHGRVYQKGHELVLANIAESD 385
           +P V+ A  G    V CL    L + +V  W   GV L  + R    G  L +      D
Sbjct: 46  QPEVYVAAPGESLEVRCL----LKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRD 101

Query: 386 AGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVW 445
           +G+Y C A+           + V    S          E+   G  D +++ +      +
Sbjct: 102 SGLYACTASRTVDSETWYFMVNVTDAIS------SGDDEDDTDGAEDFVSENSNNKRAPY 155

Query: 446 YRNQMLISEDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505
           + N   + +            R+++V   +   +RC    PAG         + +G    
Sbjct: 156 WTNTEKMEK------------RLHAVPAANTVKFRC----PAGGNPMPTMRWLKNGKEFK 199

Query: 506 E-------WVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVA------VFI 552
           +        V +   +L    V   D GNYTC+  N   G I     L V         +
Sbjct: 200 QEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVEN-EYGSINHTYHLDVVERSPHRPIL 258

Query: 553 TFKVEPERTTVYQGHTALLQCEAQGDPKPLIQW 585
              +    +TV  G    + C+   D +P IQW
Sbjct: 259 QAGLPANASTVVGGDVEFV-CKVYSDAQPHIQW 290



 Score = 37.0 bits (84), Expect = 0.096
 Identities = 55/232 (23%), Positives = 87/232 (37%), Gaps = 56/232 (24%)

Query: 132 KHPASEAEIQ---PQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLR 188
           K+  S+ E+    P   + +RC +         W +DG  L  G +N TV   E  L ++
Sbjct: 41  KYQISQPEVYVAAPGESLEVRCLLKD--AAVISWTKDGVHL--GPNNRTVLIGEY-LQIK 95

Query: 189 PAGPEHSGLYSCCAHSAFGQACSSQNFTLSIAD--------------ESF----ARVVLA 230
            A P  SGLY+C A         +  F +++ D              E F    +    A
Sbjct: 96  GATPRDSGLYACTASRTVDS--ETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRA 153

Query: 231 PQDVVVARYEEAM----------FHCQFSAQPPPSLQWL-----FEDETPITN-RSRPPH 274
           P      + E+ +          F C     P P+++WL     F+ E  I   + R  H
Sbjct: 154 PYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQH 213

Query: 275 LRRATVFANGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMP 326
                     SL++  V P + G Y C+ + + G    +  T HL  +E  P
Sbjct: 214 ---------WSLIMESVVPSDKGNYTCVVENEYGS---INHTYHLDVVERSP 253


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
            [Homo sapiens]
          Length = 694

 Score =  211 bits (536), Expect = 4e-54
 Identities = 177/598 (29%), Positives = 269/598 (44%), Gaps = 78/598 (13%)

Query: 482  MSSTPAGSIEAQARVQVLDGSSL--PEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQ 539
            +S  P G       V V DG+ L   E V      L     + +D+G Y+C      +  
Sbjct: 59   LSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVL 118

Query: 540  IRAHVQLT-------------------VAVFITFKVEPERT-----TVYQGHTALLQCEA 575
                V++T                   V     +   PER       V   +T   +C A
Sbjct: 119  CHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPA 178

Query: 576  QGDPKPLIQW-KGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGNSC-NIK 633
             G+P P I W K         ++G      Q  SLV+  V P D G YTC+  N   +I+
Sbjct: 179  AGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIR 238

Query: 634  HTEAPLYVVDKPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYIIAVLG--LMFYCK---- 687
             T    Y +D  V E S       P++ I   GL          AVLG  + F+CK    
Sbjct: 239  QT----YTLD--VLERS-------PHRPILQAGLPANQT-----AVLGSDVEFHCKVYSD 280

Query: 688  --------KRCKAKRLQKQPEGEEPEMECLNGGPLQNGQPSAEIQ-EEVALTSLGSGPAA 738
                    K  +    +  P+G  P +  L      N   S+      +A  S G GP  
Sbjct: 281  AQPHIQWLKHVEVNGSKVGPDGT-PYVTVLKVSLESNASMSSNTPLVRIARLSSGEGPTL 339

Query: 739  TNKRH---STSDKMHFPRSSLQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSK 795
             N          K    R+ L     LG+  FG+V +A+A G+++  A   V V     K
Sbjct: 340  ANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK 399

Query: 796  DEQQQLDFR---RELEMFGKLN-HANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISK 851
            D+    D      E+EM   +  H N++ LLG C +  P Y+++EY   G+L++FLR  +
Sbjct: 400  DDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR 459

Query: 852  ------SKDE-KLKSQPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQV 904
                  S D  K   + L+ K  V+   QVA GME+L++ + +H+DLAARN LV+    +
Sbjct: 460  PPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVM 519

Query: 905  KVSALGLSKDVYNSEYY-HFRQAWVPLRWMSPEAILEGDFSTKSDVWAFGVLMWEVFTHG 963
            K++  GL++DV+N +YY       +P++WM+PEA+ +  ++ +SDVW+FGVL+WE+FT G
Sbjct: 520  KIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLG 579

Query: 964  EMPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASAL 1021
              P+ G   +E+   L+ G  R+ +P  C   LY +M+ CW  +P  RP+F ++   L
Sbjct: 580  GSPYPGIPVEELFKLLKEGH-RMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 636



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 55/259 (21%), Positives = 90/259 (34%), Gaps = 48/259 (18%)

Query: 37  QPSSQDAL---QGRRALLRCEVEAPGPVH-VYWLLDGAPVQDTERRFAQGSSLSFAAVDR 92
           +P  Q+ L    G    L C     GP+    W+ DG  +  +ER       L       
Sbjct: 42  EPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASH 101

Query: 93  LQDSGTFQCVAR--------------------DDVTGEEARSANASFNIKWIEAGPVVLK 132
            +DSG + C  R                    DD  GE+            ++ G     
Sbjct: 102 -EDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTG------VDTGAPYWT 154

Query: 133 HPASEAE----IQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSS-----KER 183
            P    +    +     V  RC   G+P P+  W ++G    + +  H +       ++ 
Sbjct: 155 RPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNG---REFRGEHRIGGIKLRHQQW 211

Query: 184 NLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFTLSIADESFARVVL---APQDVVVARYE 240
           +L +    P   G Y+C   + FG     Q +TL + + S  R +L    P +       
Sbjct: 212 SLVMESVVPSDRGNYTCVVENKFGSI--RQTYTLDVLERSPHRPILQAGLPANQTAVLGS 269

Query: 241 EAMFHCQFSAQPPPSLQWL 259
           +  FHC+  +   P +QWL
Sbjct: 270 DVEFHCKVYSDAQPHIQWL 288



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 67/292 (22%), Positives = 96/292 (32%), Gaps = 59/292 (20%)

Query: 329 EPRVFTAGSEERVTCLPPKGLPEPSVWWEHAGVRLPTHGRVYQKGHELVLANIAESDAGV 388
           E  VF +G    ++C PP G P     W   G  L    RV      L + N +  D+G 
Sbjct: 47  EQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGA 106

Query: 389 YTCHAANLAGQRRQDVNITVATVPS------WLKKPQDSQLEEG-----KPGYLDCLTQA 437
           Y+C    L  +     ++ V   PS         + +D+ ++ G     +P  +D    A
Sbjct: 107 YSCR-QRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLA 165

Query: 438 TPKPTVVWYRNQMLISEDSRFEVFKN-----GTLRINSVEVYDGTWYRCMSSTPAGSIEA 492
            P    V +R     +        KN     G  RI  +++    W   M S        
Sbjct: 166 VPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMES-------- 217

Query: 493 QARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVF- 551
                                      V   D GNYTC+  N   G IR    L V    
Sbjct: 218 ---------------------------VVPSDRGNYTCVVEN-KFGSIRQTYTLDVLERS 249

Query: 552 ----ITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGP 599
               I     P   T   G      C+   D +P IQW  K   ++ +K+GP
Sbjct: 250 PHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL-KHVEVNGSKVGP 300


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,903,522
Number of Sequences: 37866
Number of extensions: 2269971
Number of successful extensions: 16613
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 617
Number of HSP's successfully gapped in prelim test: 521
Number of HSP's that attempted gapping in prelim test: 5890
Number of HSP's gapped (non-prelim): 5526
length of query: 1030
length of database: 18,247,518
effective HSP length: 112
effective length of query: 918
effective length of database: 14,006,526
effective search space: 12857990868
effective search space used: 12857990868
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press