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Search of human proteins with 228008351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|228008351 coiled-coil domain containing 48 [Homo sapiens]
(598 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|228008351 coiled-coil domain containing 48 [Homo sapiens] 1185 0.0
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 52 2e-06
gi|21735548 centrosomal protein 2 [Homo sapiens] 49 1e-05
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 49 1e-05
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 49 1e-05
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 49 1e-05
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 48 3e-05
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 46 1e-04
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 46 1e-04
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 46 1e-04
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 45 1e-04
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 45 1e-04
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 45 1e-04
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 45 1e-04
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 45 2e-04
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 45 2e-04
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 45 2e-04
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 45 2e-04
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 45 2e-04
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 45 2e-04
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 45 2e-04
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 45 2e-04
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 45 2e-04
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 45 2e-04
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 45 2e-04
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 45 2e-04
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 45 2e-04
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 45 2e-04
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 45 2e-04
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 45 2e-04
>gi|228008351 coiled-coil domain containing 48 [Homo sapiens]
Length = 598
Score = 1185 bits (3065), Expect = 0.0
Identities = 598/598 (100%), Positives = 598/598 (100%)
Query: 1 MEPVSTGAEAGMEGAGGDPYRRPARRTQWLLSALAHHYGLDRGVENEIVVLATGLDQYLQ 60
MEPVSTGAEAGMEGAGGDPYRRPARRTQWLLSALAHHYGLDRGVENEIVVLATGLDQYLQ
Sbjct: 1 MEPVSTGAEAGMEGAGGDPYRRPARRTQWLLSALAHHYGLDRGVENEIVVLATGLDQYLQ 60
Query: 61 EVFHHLDCRGAGRLPRADFRALCAVLGLRAEGATTAGQAAGDGNSRDVTPGDAAAELATD 120
EVFHHLDCRGAGRLPRADFRALCAVLGLRAEGATTAGQAAGDGNSRDVTPGDAAAELATD
Sbjct: 61 EVFHHLDCRGAGRLPRADFRALCAVLGLRAEGATTAGQAAGDGNSRDVTPGDAAAELATD 120
Query: 121 GDSDTDEEARLALRAEPPELTFRQFHARLCGYFGTRAGPRLPRGALSEHIETQIRLRRPR 180
GDSDTDEEARLALRAEPPELTFRQFHARLCGYFGTRAGPRLPRGALSEHIETQIRLRRPR
Sbjct: 121 GDSDTDEEARLALRAEPPELTFRQFHARLCGYFGTRAGPRLPRGALSEHIETQIRLRRPR 180
Query: 181 RRRRPPCAPGPDSGPDCERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQA 240
RRRRPPCAPGPDSGPDCERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQA
Sbjct: 181 RRRRPPCAPGPDSGPDCERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQA 240
Query: 241 STHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVR 300
STHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVR
Sbjct: 241 STHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVR 300
Query: 301 ELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDP 360
ELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDP
Sbjct: 301 ELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDP 360
Query: 361 TPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLA 420
TPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLA
Sbjct: 361 TPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLA 420
Query: 421 RLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTS 480
RLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTS
Sbjct: 421 RLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTS 480
Query: 481 EEEAELQQKVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNISKRALGKI 540
EEEAELQQKVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNISKRALGKI
Sbjct: 481 EEEAELQQKVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNISKRALGKI 540
Query: 541 LLSTLDAFRDPTHEGRPSPAAILDALHQALAACQLLRRQPSAPASAAAALTNPLLVSC 598
LLSTLDAFRDPTHEGRPSPAAILDALHQALAACQLLRRQPSAPASAAAALTNPLLVSC
Sbjct: 541 LLSTLDAFRDPTHEGRPSPAAILDALHQALAACQLLRRQPSAPASAAAALTNPLLVSC 598
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 52.0 bits (123), Expect = 2e-06
Identities = 82/316 (25%), Positives = 127/316 (40%), Gaps = 19/316 (6%)
Query: 188 APGPDSGPDCERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTH-EMG 246
A D G D E V LEE+ + R+ V+ L A + R LA + + H +
Sbjct: 3093 AESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYA-LRKLAGTLERGAPRRYPHIQAQ 3151
Query: 247 HGGPEAAVRELRQAQGALA---AAEARAGRLRRGQAEVRRRAEEARQVVLRSL--HRVRE 301
EAA L QA A AA ++ AE++ R +E ++ H +
Sbjct: 3152 RSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSS 3211
Query: 302 LEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPT 361
+ L QQ L+R + +E E+ R ++E +L QL PG + E T
Sbjct: 3212 VRTLQQQHRRLERELEAMEKEVARLQTEACRLG--QLHPAAPGGLAKVQEAWATLQAKAQ 3269
Query: 362 PEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLAR 421
G W + ++ G L E L + E Q + EE+ E+ E+ + + L
Sbjct: 3270 ERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDVAGAEQL--LGQHEELGQE 3327
Query: 422 LSSCRGRCDDQTAE-KLMTYFGHFGGANHAHTLGELEACIAMLVE--QLRTQGCGGRTLG 478
+ CR + D E + + HF A L ELE + L E LR Q C
Sbjct: 3328 IRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRC-----A 3382
Query: 479 TSEEEAELQQKVEENE 494
S +L+Q++E+ E
Sbjct: 3383 ESWGLQKLRQRLEQAE 3398
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 49.3 bits (116), Expect = 1e-05
Identities = 88/359 (24%), Positives = 146/359 (40%), Gaps = 70/359 (19%)
Query: 200 VARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEM------GHGGPEAA 253
+A E+ +L E L A LQ ++ LQ L Q E+ EAA
Sbjct: 647 LAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAA 706
Query: 254 VRELRQA-QGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGL 312
+L Q Q A E A ++ +A VR +A A +V L+++ R R+ LA+Q+ GL
Sbjct: 707 TTQLEQLHQEAKRQEEVLARAVQEKEALVREKA--ALEVRLQAVERDRQ--DLAEQLQGL 762
Query: 313 QRWVRRLEAELQRYRSEDSQLPTP------QLANPEPGDKSNEPEDAGTRDPDPTPEGAW 366
LE+ L + ++S + Q+ + + E + T
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822
Query: 367 QSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEE--ERWQEEKKTPAAEAKTLLARLSS 424
+ + + +R L + +++ ++E Q A+ E+EV + E+W++E+ E L L
Sbjct: 823 EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLE- 881
Query: 425 CRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEA 484
EK+ ELE M +++ +T E EA
Sbjct: 882 ---------REKM-----------------ELE----MRLKEQQT-----------EMEA 900
Query: 485 ELQQKVEENEHLRLEL--QMVETERVRLSLLE------EKLVDVLQLLQRLR-DLNISK 534
Q+ EE L +ETE+ R+SLLE ++L D Q L+RLR D+ + K
Sbjct: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQK 959
Score = 36.6 bits (83), Expect = 0.068
Identities = 59/227 (25%), Positives = 94/227 (41%), Gaps = 30/227 (13%)
Query: 198 ERVARLEEENS-------SLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGP 250
E+ RLEEE + +L E++ DLRA + + LALQ QA HE+
Sbjct: 1866 EQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQC-AEQAQEHEV---ET 1921
Query: 251 EAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVP 310
A QAQ L + L R +++ R EEA + +L EAL +
Sbjct: 1922 RALQDSWLQAQAVLKERDQELEAL-RAESQSSRHQEEAARARAEALQ-----EALGKAHA 1975
Query: 311 GLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDA------GTRDPDPTPEG 364
LQ + L + + RS ++ T Q + S + E+A +D D
Sbjct: 1976 ALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL---- 2031
Query: 365 AWQSDSSSGSRALDEVDEQLFRSVEGQAASDE---EEVEEERWQEEK 408
+Q D +AL + DE+L E + ++ + V+E QE++
Sbjct: 2032 RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQ 2078
Score = 35.0 bits (79), Expect = 0.20
Identities = 77/361 (21%), Positives = 133/361 (36%), Gaps = 58/361 (16%)
Query: 202 RLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVRELRQAQ 261
+LE++ L V + L + + LQ L +++ E G ++ +L +AQ
Sbjct: 1754 QLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAR----EQGELKEQSLQSQLDEAQ 1809
Query: 262 GALAAAEARAGRLR------RGQAEVRRRAEEARQVVLRSLH-----RVRELEALAQQVP 310
ALA + L+ +GQ E + +A Q L H R EL+ +Q
Sbjct: 1810 RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQAR 1869
Query: 311 GLQ-------RWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPE 363
L+ R V+ LE L R+E + LA + + + + TR
Sbjct: 1870 RLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETR------- 1922
Query: 364 GAWQSDSSSGSRALDEVDEQL-FRSVEGQAASDEEEVEEERWQ----------------- 405
A Q L E D++L E Q++ +EE R +
Sbjct: 1923 -ALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKE 1981
Query: 406 -------EEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGAN--HAHTLGEL 456
E ++ A TL A L +C+ Q E L G + + + +L
Sbjct: 1982 QHLLEQAELSRSLEASTATLQASLDACQAH-SRQLEEALRIQEGEIQDQDLRYQEDVQQL 2040
Query: 457 EACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEEK 516
+ +A E+LR Q + L S + + ++E ++L E + E + S+ E +
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 517 L 517
L
Sbjct: 2101 L 2101
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 49.3 bits (116), Expect = 1e-05
Identities = 93/378 (24%), Positives = 154/378 (40%), Gaps = 50/378 (13%)
Query: 201 ARLEEENSSLRELVEDLR----------------AALQSSDARCLALQVGLW------KS 238
AR E +S+LRE V+ LR Q+ A L ++ W K
Sbjct: 1281 ARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKE 1340
Query: 239 QA-STHEMGHGGPEAAVRELRQAQ---GALAAAEARAGRLRRGQAEVRRRAEEA-RQVVL 293
QA ST ++ H +A V EL A+ L A +A A + R + E ++A R +L
Sbjct: 1341 QALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL 1400
Query: 294 RSLHRVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQ--LA--NPEPGDKSN- 348
R+ + EL L Q+V +R ++L AE Y + S L LA N G+++N
Sbjct: 1401 RAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL 1460
Query: 349 -----EPEDAGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEE----- 398
E E R+ A ++D+ + + + R +E A E
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL 1520
Query: 399 VEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEA 458
E +R+QEE++ A+ + L R + E+L A+ +L+A
Sbjct: 1521 EERQRFQEERQKLTAQVEQL-----EVFQREQTKQVEELSKKLADSDQASKVQQ-QKLKA 1574
Query: 459 CIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEEKLV 518
A E Q +E +A+L QK + EH +L+++ +T ++L
Sbjct: 1575 VQAQGGES--QQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQ 1632
Query: 519 DVLQLLQRLRDLNISKRA 536
+ L+ L++L+ N RA
Sbjct: 1633 EQLRSLEQLQKENKELRA 1650
Score = 37.7 bits (86), Expect = 0.030
Identities = 82/403 (20%), Positives = 159/403 (39%), Gaps = 45/403 (11%)
Query: 127 EEARLALRAEPPELTFRQF-HARLCGYFGTRAGPRLPRGALSEHIETQIRLRRPRRRRRP 185
EE R ++ +L ++ HA G AG P G E + ++ + +++
Sbjct: 1081 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1140
Query: 186 PCAPGPDSGPDCERVARLEEENS--SLRELVEDLRAALQSSDARCLALQ--VGLWKSQAS 241
A + + ER +R E +++ +L+ +E+ L S + + Q + ++++
Sbjct: 1141 EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1200
Query: 242 THEMGHGGPEAAV----RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLH 297
H +A V +E + +++ E L R E ++E +++V+
Sbjct: 1201 DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESE 1260
Query: 298 RVRELE-----ALAQQVPGLQRWVRR---LEAELQRYRSE-DSQLPTPQLANPEPGDKSN 348
+ ++LE A+ R R L E+Q R E + Q + E ++
Sbjct: 1261 KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAE 1320
Query: 349 EPEDAGTRDPDPTPEGAWQSDSSSGSRALDEVDEQ-----------LFRSVEGQAASDEE 397
E+ G ++ E +Q + + + L+ Q L + ++ + A+ E+
Sbjct: 1321 RAEELG-QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379
Query: 398 EVEEERWQEEKKTPAAEAKTL-----LARLSSCRGRCDDQ--TAEKLMTYFGHFGGANHA 450
EE Q ++ A+ L L L R + +Q TA++L A++A
Sbjct: 1380 RHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRA-----EKASYA 1434
Query: 451 HTLGELEACIAMLVEQLRTQGCGGR-TLGTSEEEAELQQKVEE 492
L L+ +L E+ R G G R LG E EL Q E+
Sbjct: 1435 EQLSMLKKAHGLLAEENR--GLGERANLGRQFLEVELDQAREK 1475
Score = 36.2 bits (82), Expect = 0.088
Identities = 80/362 (22%), Positives = 135/362 (37%), Gaps = 47/362 (12%)
Query: 201 ARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVRELRQA 260
A ++ L E+ A+L+ DA L+ L K +A+ E+ + A A
Sbjct: 576 ATRQDHAQQLATAAEEREASLRERDAALKQLEA-LEKEKAAKLEILQQQLQVANEARDSA 634
Query: 261 QGALAAAEARAGRLRRGQAEVRRRAEEARQ-------------VVLRS-LHRVRELEALA 306
Q ++ A+ L R E++ E ARQ + LRS + E E +A
Sbjct: 635 QTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVA 694
Query: 307 QQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRD--PDPTPEG 364
Q+ LQ ++ L+ L+ + + E + A TR E
Sbjct: 695 QEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRER 754
Query: 365 AWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQE---EKKTPAAEAKTLLAR 421
+ +G + L+ +QL G+A E EV E + T +E + L+
Sbjct: 755 KELEEERAGRKGLEARLQQL-----GEAHQAETEVLRRELAEAMAAQHTAESECEQLVKE 809
Query: 422 LSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSE 481
+++ R R +D E+ +G + E C E + + E
Sbjct: 810 VAAWRERYEDSQQEE-----AQYGAMFQEQLMTLKEECEKARQELQEAK----EKVAGIE 860
Query: 482 EEAELQQKVEENE------HLRLELQMVETERVR-------LSLLEEKLVDVLQLLQRLR 528
+ELQ ++NE +L LQ V+ + VR LS L+EK+ + + RL
Sbjct: 861 SHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE 920
Query: 529 DL 530
L
Sbjct: 921 TL 922
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 48.9 bits (115), Expect = 1e-05
Identities = 87/350 (24%), Positives = 140/350 (40%), Gaps = 63/350 (18%)
Query: 186 PCAPGPDSGPDCERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEM 245
P +PGP + P + E +LRE +++LR+A + D L Q Q + E
Sbjct: 1488 PPSPGPATSPASPDLDP-EAVRGALREFLQELRSAQRERDE--LRTQTSALNRQLAEMEA 1544
Query: 246 GHGGPEAAVRELRQAQGALAAAEARA----GRLRRGQAEVRRRAEEARQVVLRSLHRVRE 301
++A RQ Q A+A +E GRL QAE+ + E R+ RE
Sbjct: 1545 ER---DSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRR-------SERE 1594
Query: 302 LEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPT 361
A QV L+R ++ E+EL+ + + S++ K+NE + G +
Sbjct: 1595 RRATLDQVATLERSLQATESELRASQEKISKM------------KANETKLEGDK----- 1637
Query: 362 PEGAWQSDSSSGSRALDEV-DEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLA 420
R L EV D R+V+ + E E +R + A+A+ L
Sbjct: 1638 -------------RRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQD 1684
Query: 421 RLSSCRGRCDDQ--TAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLG 478
R+ S + + D A L GA L ++E L +++R G T
Sbjct: 1685 RVDSLQRQVADSEVKAGTLQLTVERLNGA-----LAKVEESEGALRDKVR-----GLTEA 1734
Query: 479 TSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLR 528
++ A L ++N HL+ L E +R +L+E+L Q L R
Sbjct: 1735 LAQSSASLNSTRDKNLHLQKALTACEHDR---QVLQERLDAARQALSEAR 1781
Score = 35.0 bits (79), Expect = 0.20
Identities = 70/296 (23%), Positives = 113/296 (38%), Gaps = 45/296 (15%)
Query: 251 EAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVP 310
EA R R+ + A +L + E R +EEA ++ L E EAL +
Sbjct: 862 EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRL-------EKEALEGSLF 914
Query: 311 GLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDS 370
+QR + +LEA ++ +E L + ++ E AG R + D
Sbjct: 915 EVQRQLAQLEARREQLEAEGQALLLAK--------ETLTGELAGLRQQIIATQEKASLDK 966
Query: 371 SSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCD 430
++ L + + + S+ Q A+ EE++ +R Q EK+ E + A+L S R
Sbjct: 967 ELMAQKLVQAEREAQASLREQRAAHEEDL--QRLQREKEAAWRELEAERAQLQSQLQREQ 1024
Query: 431 DQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKV 490
++ +L EL IA L +Q R +G L SE++ L K
Sbjct: 1025 EELLARLEA------------EKEELSEEIAAL-QQERDEGL---LLAESEKQQALSLKE 1068
Query: 491 EENEHL------------RLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNISK 534
E L + L+M +R S E+ V L LRDL +
Sbjct: 1069 SEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQR 1124
Score = 34.3 bits (77), Expect = 0.34
Identities = 117/482 (24%), Positives = 174/482 (36%), Gaps = 96/482 (19%)
Query: 102 DGNSRDVTPGDAAAELATDGDSDTDEEARLALRAEPPELTFRQFHARLCGYFGTRAGPRL 161
DG T D A + +D +S ++ E T + L G G R P
Sbjct: 445 DGEGLQQTLRDLAQAVLSDSES--------GVQLSGSERTADASNGSLRGLSGQRT-PSP 495
Query: 162 PRGALSEHIETQIRLRRPRRRRRPPCAPGPDSGPDCERVARLEEENSSLR-------ELV 214
PR + + R R PRR P C+ + + + + +R +L+
Sbjct: 496 PRRS------SPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLL 549
Query: 215 EDLRAALQSSDARCLALQVGLWKSQASTHE--MGHGGPEAAVRELRQAQGALA------- 265
LR L S++ AL+ L + + T H + V+ LR A L+
Sbjct: 550 GTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLA 609
Query: 266 ---------AAEARAGR--LRRGQAEVRR---RAEEARQVVLRSLHRVR-ELEALAQQVP 310
A E R R L+ Q E+RR R EE ++ ++ RVR ELE +Q+
Sbjct: 610 HSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLE 669
Query: 311 GLQRWVRRLEAELQRYRSEDS----QLPTPQLANPEPGDKSNEPEDAGTRDPDPT----- 361
L+ L EL R S Q Q E + + E AG + + +
Sbjct: 670 QLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAE-AGRVELELSMTKLR 728
Query: 362 PEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVE----EERWQEEKKTPAAEAKT 417
E A DS S AL+E Q + A EEE +R E++ T A E +
Sbjct: 729 AEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQE 788
Query: 418 LLARLSSCRGRCDDQTAEKLMTYFGHFGGANHA------------HTLGELEACIAMLVE 465
L L R + + A + + G A A H +L+ +A L
Sbjct: 789 RLEEL-----RLEQEVARQGLE--GSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR 841
Query: 466 QLRTQGCGGRTLGTSEEEAELQQKVEE------------NEHLRLELQMVETERVRLSLL 513
QL GR + E Q++VE EH L +Q+V ER +L
Sbjct: 842 QL-----SGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLS 896
Query: 514 EE 515
EE
Sbjct: 897 EE 898
Score = 33.5 bits (75), Expect = 0.57
Identities = 76/335 (22%), Positives = 130/335 (38%), Gaps = 37/335 (11%)
Query: 201 ARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVRELRQA 260
+R E++ S++ L +LR + A + + Q ++G ++ +RE +
Sbjct: 1101 SRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQR-DSCLREAEEL 1159
Query: 261 QGALAAAEARAGRLRRGQAEVRRR---AEEARQVVLRSLHRV-RELEALAQQVPGLQRWV 316
+ L E LRR E +R+ ++E R+V + + R L A++ L+R
Sbjct: 1160 RTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSN 1219
Query: 317 RRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGT---RDPDPTPEGAWQSDSS-- 371
L + +++ SE L +LAN + K E+A T ++ G + + S
Sbjct: 1220 EELRSAVKKAESERISL---KLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRL 1276
Query: 372 SGSRALDEVDEQL-------------FRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTL 418
R L E+ Q+ ++G+ A E +E R ++T + L
Sbjct: 1277 EARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR----RETLGLRQRLL 1332
Query: 419 LARLSSCRGRCDDQTAE-KLMTYFGHFGGANHAHTLGELEACIAMLVEQL-RTQGCGGRT 476
S R + Q A+ KL G F LG LE +QL +G +
Sbjct: 1333 KGEASLEVMRQELQVAQRKLQEQEGEF-RTRERRLLGSLEEARGTEKQQLDHARGLELKL 1391
Query: 477 LGTSEEEAELQQKVEENE----HLRLELQMVETER 507
E AEL ++ E L EL VE +R
Sbjct: 1392 EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQR 1426
Score = 33.1 bits (74), Expect = 0.75
Identities = 76/302 (25%), Positives = 119/302 (39%), Gaps = 36/302 (11%)
Query: 237 KSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSL 296
++QAS E E R R+ + A EA +L Q++++R EE +L L
Sbjct: 979 EAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQL---QSQLQREQEE----LLARL 1031
Query: 297 HRVRELEALAQQVPGLQR----WVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPED 352
E E L++++ LQ+ + E+E Q+ S T L+ G + +
Sbjct: 1032 EA--EKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTA-LSEKLMGTRHSLATI 1088
Query: 353 AGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPA 412
+ + + Q S AL L E AA+ +EV R QE+
Sbjct: 1089 SLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVR--RLQEQ----- 1141
Query: 413 AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQ----LR 468
A+ L + SC + AE+L T A LEA + Q ++
Sbjct: 1142 --ARDLGKQRDSCL-----REAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194
Query: 469 TQGCGG--RTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQR 526
Q G R+LG +E E ++ NE LR ++ E+ER+ L L E L LL+
Sbjct: 1195 RQEAGELRRSLGEGAKEREALRR--SNEELRSAVKKAESERISLKLANEDKEQKLALLEE 1252
Query: 527 LR 528
R
Sbjct: 1253 AR 1254
Score = 33.1 bits (74), Expect = 0.75
Identities = 57/256 (22%), Positives = 102/256 (39%), Gaps = 39/256 (15%)
Query: 200 VARLEEENSSLRELVEDLRAALQSSDA-------RCLALQVGLWKSQASTHEMGH--GGP 250
+A++EE +LR+ V L AL S A + L LQ L + +
Sbjct: 1714 LAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAA 1773
Query: 251 EAAVRELRQAQGALA------AAEARAGRLRRGQA--------EVRRRAEEARQVVLRSL 296
A+ E R+ +L E L+R +A EV R+ +E L ++
Sbjct: 1774 RQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTV 1833
Query: 297 HRVRELEALAQQVPG-LQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGT 355
++++ L Q+ G LQR + +LEAE + +L ++A DK +
Sbjct: 1834 QKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSH 1893
Query: 356 RDP----------DPTPEGAWQSDSSSGSRALDEVDEQLF----RSVEGQAASDEEEVEE 401
D D T GA + + + R + +++ Q+ Q D ++ +
Sbjct: 1894 EDTVRLSAEKGRLDRTLTGA-ELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQL 1952
Query: 402 ERWQEEKKTPAAEAKT 417
E QE ++ +A+A+T
Sbjct: 1953 ELQQEVERLRSAQAQT 1968
Score = 31.6 bits (70), Expect = 2.2
Identities = 33/127 (25%), Positives = 54/127 (42%), Gaps = 11/127 (8%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
+++A LEE +++ + +LR LQ + L + L + + + REL
Sbjct: 1245 QKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLG-REL 1303
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQRWVR 317
+ QG LA E R + E RR RQ R L LE + Q++ QR ++
Sbjct: 1304 AELQGRLALGE-------RAEKESRRETLGLRQ---RLLKGEASLEVMRQELQVAQRKLQ 1353
Query: 318 RLEAELQ 324
E E +
Sbjct: 1354 EQEGEFR 1360
Score = 30.4 bits (67), Expect = 4.8
Identities = 52/210 (24%), Positives = 87/210 (41%), Gaps = 42/210 (20%)
Query: 203 LEEENSSLRE---LVEDLRAALQSSDARCLALQVGLWKSQASTHEMG---HGGPEAAVRE 256
L+EEN L++ VEDL A +S+A E+ + E +
Sbjct: 79 LQEENQLLQQELSRVEDLLA-----------------QSRAERDELAIKYNAVSERLEQA 121
Query: 257 LRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQRWV 316
LR G L E R L R E+RR+ +E + R L +E + Q+ V
Sbjct: 122 LRLEPGELETQEPRG--LVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQL------V 173
Query: 317 RRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTP--EGAW--QSDSSS 372
+RL+ ++ +Y+ S+L L ++S E E RD + + E A +
Sbjct: 174 QRLQGKILQYKKRCSELEQQLL------ERSGELEQQRLRDTEHSQDLESALIRLEEEQQ 227
Query: 373 GSRALDEVDEQLFRSVEGQAASDEEEVEEE 402
S +L +V+ L ++ QA S + + E+
Sbjct: 228 RSASLAQVNAMLREQLD-QAGSANQALSED 256
Score = 30.0 bits (66), Expect = 6.3
Identities = 49/183 (26%), Positives = 66/183 (36%), Gaps = 24/183 (13%)
Query: 251 EAAVRELRQAQGALAAAEARAGRLRR--GQAEVRRRAEEA-----RQVVLRSLHRVRELE 303
EAA E + L+AAE RA L + EV+RRA EA R + R L R
Sbjct: 1392 EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS 1451
Query: 304 ALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDA-GTRDPDPTP 362
+ VPG R AE L +P PG + P A PD P
Sbjct: 1452 PAPRPVPGSP--ARDAPAE-----GSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDP 1504
Query: 363 EGA------WQSDSSSGSRALDEVDEQ---LFRSVEGQAASDEEEVEEERWQEEKKTPAA 413
E + + S R DE+ Q L R + A + R ++ +
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE 1564
Query: 414 EAK 416
EA+
Sbjct: 1565 EAR 1567
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 48.9 bits (115), Expect = 1e-05
Identities = 85/376 (22%), Positives = 157/376 (41%), Gaps = 47/376 (12%)
Query: 200 VARLEEENS---SLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVRE 256
++++E+E + L++ +++L+A ++ A + K++ ++ E + R
Sbjct: 1094 ISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISER- 1152
Query: 257 LRQAQGALAAA-------EARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQV 309
L +A GA +A EA +LRR E + EA LR H + L +Q+
Sbjct: 1153 LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQ-HEAMVAALRKKH-ADSMAELGEQI 1210
Query: 310 PGLQRWVRRLEAELQRYRSEDSQLPT-PQLANPEPGD---------------KSNEPEDA 353
LQR ++LE E + E L + + + G+ K+ E E
Sbjct: 1211 DNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQ 1270
Query: 354 GTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAA 413
+ Q+++ SR LDE D + + + AS +++EE + Q E++T A
Sbjct: 1271 RLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQAS-TQQIEELKHQLEEETKAK 1329
Query: 414 EAKTLLARLSSCRGRCD---DQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQ 470
A L L S R CD +Q E+ G A L + + +A + T
Sbjct: 1330 NA--LAHALQSSRHDCDLLREQYEEE------QEGKAELQRALSKANSEVAQWRTKYETD 1381
Query: 471 GCGGRTLGTSEEEAELQQKVEENEH----LRLELQMVETERVRL-SLLEEKLVDVLQLLQ 525
RT E + +L Q+++E E + + +E + RL + +E+ ++DV +
Sbjct: 1382 AI-QRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNA 1440
Query: 526 RLRDLNISKRALGKIL 541
L+ +R K+L
Sbjct: 1441 ACAALDKKQRNFDKVL 1456
Score = 34.3 bits (77), Expect = 0.34
Identities = 82/418 (19%), Positives = 160/418 (38%), Gaps = 52/418 (12%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
+R LEE L + +++ +++ +A+C +L+ T + E + ++
Sbjct: 1384 QRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLE--------KTKQRLQNEVEDLMLDV 1435
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVREL-----------EALA 306
++ A AA + + + +E +++ EE + + S R L E
Sbjct: 1436 ERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESL 1495
Query: 307 QQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAW 366
Q+ L+R + L+ E+ + ++ Q+ E K E E + E +
Sbjct: 1496 DQLETLRRENKNLQQEISDLTEQIAE-GGKQIHELEKIKKQVEQEKCEIQAALEEAEASL 1554
Query: 367 QSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARL-SSC 425
+ + R E++ Q+ V+ + A +EE++ + K+ +T+ + L +
Sbjct: 1555 EHEEGKILRIQLELN-QVKSEVDRKIAEKDEEID-----QLKRNHTRVVETMQSTLDAEI 1608
Query: 426 RGRCDDQTAEKLM--------TYFGHFGG------ANHAHTLGELEACIAMLVEQLRTQG 471
R R D +K M H N+ +T G L+ L + LR Q
Sbjct: 1609 RSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQE 1668
Query: 472 CGGRTLGTSEEEAE-LQQKVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDL 530
L E A LQ ++EE L + +TER R + E++L+D + +Q L
Sbjct: 1669 DLKEQLAIVERRANLLQAEIEE-----LWATLEQTERSR-KIAEQELLDASERVQLLHTQ 1722
Query: 531 NIS----KRALGKILLSTLDAFRDPTHEGRPSPAAILDALHQALAACQLLRRQPSAPA 584
N S K+ L + + E R + A+ A + L+++ A
Sbjct: 1723 NTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSA 1780
Score = 29.6 bits (65), Expect = 8.3
Identities = 41/154 (26%), Positives = 71/154 (46%), Gaps = 28/154 (18%)
Query: 198 ERVARLEEENSSL---RELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAV 254
ERV L +N+SL ++ +E+ + LQS ++ + +S+ + + +AA+
Sbjct: 1714 ERVQLLHTQNTSLINTKKKLENDVSQLQSE------VEEVIQESRNAEEKAKKAITDAAM 1767
Query: 255 --RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRS--------LHRVRELEA 304
EL++ Q A E L + +++ R +EA Q+ L+ RVRELE
Sbjct: 1768 MAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEG 1827
Query: 305 --------LAQQVPGLQRWVRRLEAELQRYRSED 330
A+ V GL++ RR++ EL ED
Sbjct: 1828 EVENEQKRNAEAVKGLRKHERRVK-ELTYQTEED 1860
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 47.8 bits (112), Expect = 3e-05
Identities = 88/384 (22%), Positives = 155/384 (40%), Gaps = 54/384 (14%)
Query: 180 RRRRRPPCAPGPDSGPDCERVA-RLEEENSSLRELVEDLRA-------ALQSSDARCLAL 231
RR++ A + +RV +LE+E S LR V+DL A A S++ C
Sbjct: 1242 RRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTY 1301
Query: 232 QVGLWKSQASTHEMGHGGPEAAVR------ELRQAQGALAAAEARAGRLRRGQA------ 279
+ L +++ E+ +A+ + E + L E +L RG+A
Sbjct: 1302 EDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSL 1361
Query: 280 -EVRRRAEEARQVVLRSLHRVREL-----------EALAQQVPGLQRWVRRLEAELQRYR 327
E+RR+ EE + H V+ L E A+ LQR + + AE+ ++R
Sbjct: 1362 EELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWR 1421
Query: 328 SEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRAL------DEVD 381
S+ + E +++ + ++ + E A SS L ++V
Sbjct: 1422 ---SKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVT 1478
Query: 382 EQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYF 441
+L R+ AA D+++ ER EE++ E + L + + E
Sbjct: 1479 LELERATSAAAALDKKQRHLERALEERRRQEEE---MQRELEAAQRESRGLGTELFRLRH 1535
Query: 442 GHFGGANHAHTL----GELEACIAMLVEQLRTQGCGGRTLGTSE-----EEAELQQKVEE 492
GH TL L+ I+ L +Q+ G + L ++ E++E+Q +EE
Sbjct: 1536 GHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEE 1595
Query: 493 NEHLRLELQMVETERVRLSLLEEK 516
E LEL+ +T R++L L + K
Sbjct: 1596 AEG-ALELEETKTLRIQLELSQVK 1618
Score = 46.2 bits (108), Expect = 9e-05
Identities = 102/451 (22%), Positives = 170/451 (37%), Gaps = 91/451 (20%)
Query: 199 RVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVRELR 258
R +LE+E + L++ ++DL+ L ++ K + +T E V+ L
Sbjct: 988 RRRKLEDECTELKKDIDDLKLTLAKAE-----------KEKQAT--------ENKVKNLT 1028
Query: 259 QAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRE-LEALAQQVPGLQRWVR 317
+ AL + AR + ++ +EA Q L L + + AL + L++ V
Sbjct: 1029 EEMAALDESVARL-------TKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVE 1081
Query: 318 RLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDA--GTRDPDPTPEGAWQSDSSSGSR 375
LE L+ + + ++ T + GD E +D E + DS
Sbjct: 1082 DLECSLE--QEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQL 1139
Query: 376 ALDEVDEQL--------FRSVEGQAASDEEEVEEE-----RWQEEKKTPAAEAKTLLARL 422
+L DEQL + ++ +A EEE+E E R ++++ A E + L RL
Sbjct: 1140 SLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERL 1199
Query: 423 SSCRGRCDDQT--AEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTS 480
G Q K G L EA +A L R Q G LG
Sbjct: 1200 EEAGGASAGQREGCRKREAELGRLRRELEEAALRH-EATVAAL---RRKQAEGAAELGEQ 1255
Query: 481 EEEAE-LQQKVE-ENEHLRLELQ----MVET---------------------ERVRLSLL 513
+ + ++QK+E E LR+E+ VET ++++ L
Sbjct: 1256 VDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEEL 1315
Query: 514 EEKLVDV-------------LQLLQRLRDLNISKRALGKILLS-TLDAFRDPTHEGRPSP 559
+ +L D L L ++ IS+ + GK L + +L+ R E +
Sbjct: 1316 QRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAK 1375
Query: 560 AAILDALHQALAACQLLRRQPSAPASAAAAL 590
+A+ A+ C LLR Q A A A L
Sbjct: 1376 SALAHAVQALRHDCDLLREQHEEEAEAQAEL 1406
Score = 44.3 bits (103), Expect = 3e-04
Identities = 84/412 (20%), Positives = 154/412 (37%), Gaps = 40/412 (9%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
+R LEE L +++ +++++A+C +L+ + Q + E EL
Sbjct: 1430 QRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTES--------EDVTLEL 1481
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVREL-----------EALA 306
+A A AA + + L R E RR+ EE ++ + + R L E
Sbjct: 1482 ERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEAL 1541
Query: 307 QQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAW 366
+ + L+R + L+ E+ + S L + E K+ E E + + EGA
Sbjct: 1542 EALETLKRENKNLQEEISDLTDQVS-LSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL 1600
Query: 367 QSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAK-TLLARLSSC 425
+ + + R E+ Q+ V+ + A +EE R ++ + +A R +
Sbjct: 1601 ELEETKTLRIQLEL-SQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNE 1659
Query: 426 RGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCG----GRTLGTSE 481
R + L G A T E +A ++ QL+ + G R
Sbjct: 1660 ALRLKKKMEGDLNDLELQLGHATRQAT--EAQAATRLMQAQLKEEQAGRDEEQRLAAELH 1717
Query: 482 EEAELQQK-----VEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNI---- 532
E+A+ ++ E E LR L+ E R L E++L++ + L L N
Sbjct: 1718 EQAQALERRASLLAAELEELRAALEQGERSR---RLAEQELLEATERLNLLHSQNTGLLN 1774
Query: 533 SKRALGKILLSTLDAFRDPTHEGRPSPAAILDALHQALAACQLLRRQPSAPA 584
K+ L L + E R + A+ A + L+++ A
Sbjct: 1775 QKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSA 1826
Score = 30.8 bits (68), Expect = 3.7
Identities = 24/77 (31%), Positives = 35/77 (45%), Gaps = 9/77 (11%)
Query: 256 ELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQRW 315
EL++ Q A E L + E++ R EEA Q LR + QV L+
Sbjct: 1817 ELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKK---------QVQKLEAK 1867
Query: 316 VRRLEAELQRYRSEDSQ 332
VR LEAEL + + ++
Sbjct: 1868 VRELEAELDAEQKKHAE 1884
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 45.8 bits (107), Expect = 1e-04
Identities = 100/440 (22%), Positives = 175/440 (39%), Gaps = 74/440 (16%)
Query: 165 ALSEHIETQIRLRRPRRRRRPPCAPGPDSGPDC-ERVARLEEENSSLRELVEDLRAA--- 220
AL E +E + R ++ R S D + V LE+ +L + VE++R
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEE 1550
Query: 221 ----LQSSDARCLALQVGLWKSQA-------STHEMGHGGPEAAVRELRQ---------A 260
LQ+++ L L+V + +A + E ++++R+
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERK 1610
Query: 261 QGALAAAEARAGRLRRGQAEVR-RRAEEARQVVLRSLHRV--------RELEALAQQVPG 311
Q ALA A + + E + A +AR V++ L ++ RELE
Sbjct: 1611 QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDE 1670
Query: 312 LQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSS 371
+ + E +L+ +E QL +LA+ E + E E D ++S+
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQL-QEELASSERARRHAEQERDELADE--------ITNSA 1721
Query: 372 SGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEE------KKTPAAEAKTLLARLSSC 425
SG AL +DE+ R +E + A EEE+EEE+ E +KT + TL A L++
Sbjct: 1722 SGKSAL--LDEK--RRLEARIAQLEEELEEEQSNMELLNDRFRKT-TLQVDTLNAELAAE 1776
Query: 426 RGRCD---------DQTAEKLMTYFGHFGGA---NHAHTLGELEACIAMLVEQL----RT 469
R ++ ++L GA T+ LEA I L EQL +
Sbjct: 1777 RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836
Query: 470 QGCGGRTLGTSEEEAE--LQQKVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRL 527
+ + + +E++ + Q +E H + +E R+ L+ +L + + R
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR- 1895
Query: 528 RDLNISKRALGKILLSTLDA 547
N S+R L + L +A
Sbjct: 1896 --ANASRRKLQRELDDATEA 1913
Score = 32.7 bits (73), Expect = 0.98
Identities = 81/391 (20%), Positives = 139/391 (35%), Gaps = 90/391 (23%)
Query: 199 RVARLEEENSSLRELVEDLRAALQSSDARCLALQ-------------VGLWKSQASTHEM 245
R+ +LEEE +SL+E E+ A ++ + + LALQ +G +S +
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKK 1396
Query: 246 GHGGPEAAVRELRQAQGALAAAEARAGRLRR----------------------------- 276
EA + L + A E RL++
Sbjct: 1397 LLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 277 ---------GQAEVRRRAE-EARQVVLRSLHRVRELEALAQQVPGLQRWVRRLEAELQRY 326
AE R RAE EAR+ ++L R LE + +R ++L A+++
Sbjct: 1457 LAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDL 1516
Query: 327 RS-------------EDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSG 373
S + + Q+ + E E T D E Q+ +
Sbjct: 1517 MSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF 1576
Query: 374 SRAL---DEVDEQLFRSVEGQAASDEEEVEEERWQE-----EKKTPAAEAKTLLARLSSC 425
R L DE +E+ R + Q E E+E+ER Q KK + K L A++ +
Sbjct: 1577 ERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAA 1636
Query: 426 RGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAE 485
D+ + L +L+A + +L + +E+E
Sbjct: 1637 NKARDEVIKQ-----------------LRKLQAQMKDYQRELEEARASRDEIFAQSKESE 1679
Query: 486 LQQKVEENEHLRLELQMVETERVRLSLLEEK 516
+ K E E L+L+ ++ +ER R +E+
Sbjct: 1680 KKLKSLEAEILQLQEELASSERARRHAEQER 1710
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 45.8 bits (107), Expect = 1e-04
Identities = 63/257 (24%), Positives = 108/257 (42%), Gaps = 34/257 (13%)
Query: 201 ARLEEENS---SLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
+++E+E + L++ +++L+A ++ + A + K++ ++ E + R L
Sbjct: 1098 SKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER-L 1156
Query: 258 RQAQGALAAA-------EARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVP 310
+A GA +A EA ++RR E + EA LR H E L +Q+
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ-HEATAATLRKKHADSVAE-LGEQID 1214
Query: 311 GLQRWVRRLEAELQRYRSE-DSQLPTPQLANPEPGD---------------KSNEPEDAG 354
LQR ++LE E + E D + + G+ KS E E
Sbjct: 1215 NLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQR 1274
Query: 355 TRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAE 414
+ G Q++S SR LDE + + + G+ A ++ E +R EE+ +
Sbjct: 1275 LINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE----IK 1330
Query: 415 AKTLLAR-LSSCRGRCD 430
AK LA L S R CD
Sbjct: 1331 AKNALAHALQSSRHDCD 1347
Score = 41.6 bits (96), Expect = 0.002
Identities = 87/411 (21%), Positives = 152/411 (36%), Gaps = 68/411 (16%)
Query: 199 RVARLEEENSSLRELVEDLRAALQSSDARCLALQ---------VGLWKSQASTHEMGHGG 249
+ A LE+ L+ VEDL ++ ++A C AL + WK + E H
Sbjct: 1416 KCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKC---EETHAE 1472
Query: 250 PEAAVRELR-------QAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVREL 302
EA+ +E R + + A + + L+R +++ + + + R+ EL
Sbjct: 1473 LEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL 1532
Query: 303 EALAQQVP----GLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDP 358
E + +QV LQ + EA L+ E+ ++ QL + KS +D
Sbjct: 1533 EKIKKQVEQEKCELQAALEEAEASLEH---EEGKILRIQLELNQV--KSEVDRKIAEKDE 1587
Query: 359 DPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQ-EEKKTPAAEAKT 417
+ +D++ R VE ++ + E+ KK +
Sbjct: 1588 E-----------------IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1630
Query: 418 LLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTL 477
+ +L+ + AE L N+ +T G L+ L + LR+Q L
Sbjct: 1631 MEIQLN----HANRMAAEAL---------RNYRNTQGILKDTQIHLDDALRSQEDLKEQL 1677
Query: 478 GTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNIS---- 533
E A L Q E E LR L+ E R + E++L+D + +Q L N S
Sbjct: 1678 AMVERRANLLQ--AEIEELRATLEQTERSR---KIAEQELLDASERVQLLHTQNTSLINT 1732
Query: 534 KRALGKILLSTLDAFRDPTHEGRPSPAAILDALHQALAACQLLRRQPSAPA 584
K+ L + D E R + A+ A + L+++ A
Sbjct: 1733 KKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1783
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 45.8 bits (107), Expect = 1e-04
Identities = 63/257 (24%), Positives = 108/257 (42%), Gaps = 34/257 (13%)
Query: 201 ARLEEENS---SLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
+++E+E + L++ +++L+A ++ + A + K++ ++ E + R L
Sbjct: 1098 SKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISER-L 1156
Query: 258 RQAQGALAAA-------EARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVP 310
+A GA +A EA ++RR E + EA LR H E L +Q+
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ-HEATAATLRKKHADSVAE-LGEQID 1214
Query: 311 GLQRWVRRLEAELQRYRSE-DSQLPTPQLANPEPGD---------------KSNEPEDAG 354
LQR ++LE E + E D + + G+ KS E E
Sbjct: 1215 NLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQR 1274
Query: 355 TRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAE 414
+ G Q++S SR LDE + + + G+ A ++ E +R EE+ +
Sbjct: 1275 LINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE----IK 1330
Query: 415 AKTLLAR-LSSCRGRCD 430
AK LA L S R CD
Sbjct: 1331 AKNALAHALQSSRHDCD 1347
Score = 41.6 bits (96), Expect = 0.002
Identities = 87/411 (21%), Positives = 152/411 (36%), Gaps = 68/411 (16%)
Query: 199 RVARLEEENSSLRELVEDLRAALQSSDARCLALQ---------VGLWKSQASTHEMGHGG 249
+ A LE+ L+ VEDL ++ ++A C AL + WK + E H
Sbjct: 1416 KCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKC---EETHAE 1472
Query: 250 PEAAVRELR-------QAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVREL 302
EA+ +E R + + A + + L+R +++ + + + R+ EL
Sbjct: 1473 LEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL 1532
Query: 303 EALAQQVP----GLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDP 358
E + +QV LQ + EA L+ E+ ++ QL + KS +D
Sbjct: 1533 EKIKKQVEQEKCELQAALEEAEASLEH---EEGKILRIQLELNQV--KSEVDRKIAEKDE 1587
Query: 359 DPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQ-EEKKTPAAEAKT 417
+ +D++ R VE ++ + E+ KK +
Sbjct: 1588 E-----------------IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1630
Query: 418 LLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTL 477
+ +L+ + AE L N+ +T G L+ L + LR+Q L
Sbjct: 1631 MEIQLN----HANRMAAEAL---------RNYRNTQGILKDTQIHLDDALRSQEDLKEQL 1677
Query: 478 GTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNIS---- 533
E A L Q E E LR L+ E R + E++L+D + +Q L N S
Sbjct: 1678 AMVERRANLLQ--AEIEELRATLEQTERSR---KIAEQELLDASERVQLLHTQNTSLINT 1732
Query: 534 KRALGKILLSTLDAFRDPTHEGRPSPAAILDALHQALAACQLLRRQPSAPA 584
K+ L + D E R + A+ A + L+++ A
Sbjct: 1733 KKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSA 1783
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 45.4 bits (106), Expect = 1e-04
Identities = 111/432 (25%), Positives = 166/432 (38%), Gaps = 80/432 (18%)
Query: 196 DCERVARL--EEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPE-- 251
+ ERVAR E++ L E +E LR L+ + A Q K + E+ E
Sbjct: 1153 ESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEET 1212
Query: 252 ----AAVRELRQAQG-ALAAAEARAGRLRRGQA--EVRRRAEEARQVVLRSLHRVRELEA 304
AAV+ELRQ G AL + + RRG+ E R A EA LR+ + L+
Sbjct: 1213 RIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA--ELSSLQT 1270
Query: 305 LAQQVPGLQRWVRRLEAELQRY--RSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTP 362
Q+ G QR RRLE +LQ R+ D + + A ++ +G + +
Sbjct: 1271 ARQE--GEQR-RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1327
Query: 363 EGAWQSDSSSGSRALDEVDEQL-------------FRSVEGQAASDEEEVEEERWQEEKK 409
+ SS L + E L R++E +AA E++EEE E+
Sbjct: 1328 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER- 1386
Query: 410 TPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRT 469
E +T A+LS R R +++ G LEA
Sbjct: 1387 -AGRELQTAQAQLSEWRRRQEEEA--------------------GALEA----------- 1414
Query: 470 QGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSL-LEEKLVDVLQLLQRLR 528
G R E EA Q+ E+ E + +E R RL L++ +D+ Q Q +
Sbjct: 1415 -GEEARRRAAREAEALTQRLAEKTE----TVDRLERGRRRLQQELDDATMDLEQQRQLVS 1469
Query: 529 DLNISKRALGKIL-------LSTLDAFRDPTHEGRPSPAAILD---ALHQALAACQLLRR 578
L +R ++L L ++ EGR A L AL + A + L R
Sbjct: 1470 TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELER 1529
Query: 579 QPSAPASAAAAL 590
Q A + AL
Sbjct: 1530 QNRALRAELEAL 1541
Score = 41.6 bits (96), Expect = 0.002
Identities = 102/463 (22%), Positives = 166/463 (35%), Gaps = 91/463 (19%)
Query: 199 RVARLEEENSSLRELVEDLRAALQSSDARCLALQVGL--WK----SQASTHEMGHGGPEA 252
RV +E E + LRE +E+ AA + + Q L W+ +A E G
Sbjct: 1362 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1421
Query: 253 AVRELRQAQGALAAAEARAGRLRRGQ---------------------------------- 278
A RE LA RL RG+
Sbjct: 1422 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1481
Query: 279 -----------AEVRRRAE-EARQVVLRSLHRVRELEALAQQVPGLQRWVRRLEAELQRY 326
E R RAE E R+ R+L R LE + L+R R L AEL+
Sbjct: 1482 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1541
Query: 327 RSEDSQL------------PTPQLAN------PEPGDKSNEPEDAGTRDPDPTPEGAWQS 368
S + Q AN E D+ EDA R + T + A ++
Sbjct: 1542 LSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR-LEVTVQ-ALKT 1599
Query: 369 DSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGR 428
+ DE E+ R + Q E E +EER +++T A A+ L G
Sbjct: 1600 QHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER---KQRTLAVAARKKL------EGE 1650
Query: 429 CDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQ 488
++ A+ M G G L +++A + L ++ + + E+E +
Sbjct: 1651 LEELKAQ--MASAGQ-GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1707
Query: 489 KVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNISKRAL---GKILLSTL 545
K E E LRL+ ++ ++R R +++ ++ + + N+SK A+ + L L
Sbjct: 1708 KGLEAEVLRLQEELAASDRARRQAQQDR----DEMADEVANGNLSKAAILEEKRQLEGRL 1763
Query: 546 DAFRDPTHEGRPSPAAILDALHQALAACQLLRRQPSAPASAAA 588
+ E + + + D + L + L + SA S +A
Sbjct: 1764 GQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA 1806
Score = 36.2 bits (82), Expect = 0.088
Identities = 91/338 (26%), Positives = 132/338 (39%), Gaps = 85/338 (25%)
Query: 202 RLEEENSSLRELV-------EDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAV 254
RL+ E+S L+E + E+LRA L + LQ L +++ GG A +
Sbjct: 1084 RLDGESSELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAE------DEGGARAQL 1134
Query: 255 -RELRQAQGALAAA--EARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPG 311
+ LR+AQ ALA A + + R+ R +AE +RR LR ELE
Sbjct: 1135 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-----ELEDTLDSTNA 1189
Query: 312 LQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSS 371
Q + E E+ + K+ E E TR E A Q
Sbjct: 1190 QQELRSKREQEVTELK------------------KTLEEE---TR----IHEAAVQELRQ 1224
Query: 372 SGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDD 431
+AL E+ EQL ++ G+ A W++ + AE L A LSS
Sbjct: 1225 RHGQALGELAEQLEQARRGKGA----------WEKTRLALEAEVSELRAELSSL------ 1268
Query: 432 QTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVE 491
QTA + G L EL+ L E G G R +E +LQ+
Sbjct: 1269 QTARQ--------EGEQRRRRL-ELQ-----LQEVQGRAGDGER--ARAEAAEKLQRAQA 1312
Query: 492 ENEHLRLELQMVETERVR----LSLLEEKLVDVLQLLQ 525
E E++ L E++ +R LS E +L D +LLQ
Sbjct: 1313 ELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1350
Score = 33.5 bits (75), Expect = 0.57
Identities = 71/313 (22%), Positives = 119/313 (38%), Gaps = 64/313 (20%)
Query: 251 EAAVRELRQAQGALAAAEARAGRLR---RGQAEVRRRAEEAR----------QVVLRSLH 297
+ + RE+ + QG +A E RL R +AE+ AEE R ++V+ L
Sbjct: 894 QQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELE 953
Query: 298 -RVRELEALAQQV----PGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPED 352
RV E E ++Q+ LQ+ ++ LEA L+ +L ++ K E
Sbjct: 954 ARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE--- 1010
Query: 353 AGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVE------------ 400
+ D +S ++ E QAA +EE+V+
Sbjct: 1011 ----------DLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT 1060
Query: 401 ----EERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGEL 456
E+R ++E+K E + L RL +Q E+ EL
Sbjct: 1061 IADMEDRLRKEEK-GRQELEKLKRRLDGESSELQEQMVEQ-------------QQRAEEL 1106
Query: 457 EACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQM-VETERVRLSLLEE 515
A + E+L Q R A+L + + E + E Q +E+ERV + E+
Sbjct: 1107 RAQLGRKEEEL--QAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEK 1164
Query: 516 KLVDVLQLLQRLR 528
+ D+ + L+ LR
Sbjct: 1165 QRRDLGEELEALR 1177
Score = 30.0 bits (66), Expect = 6.3
Identities = 63/275 (22%), Positives = 106/275 (38%), Gaps = 44/275 (16%)
Query: 166 LSEHIETQIRLRRPRRRRRPPCAPGPDSGPDCERVARLEEENS---SLRELVEDLRAALQ 222
L E + R RR ++ R A +G + + A LEE+ L +L E+L
Sbjct: 1717 LQEELAASDRARRQAQQDRDEMADEVANG-NLSKAAILEEKRQLEGRLGQLEEELEEEQS 1775
Query: 223 SSDA-----RCLALQVGLWKSQASTHEM----GHGGPEAAVRELRQAQGAL----AAAEA 269
+S+ R L LQV ++ S G + R++++ +G L A A A
Sbjct: 1776 NSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARA 1835
Query: 270 R------AGRLRRGQAE----------------VRRRAEEARQVVLRSLHRVRELEALAQ 307
R A + QAE VRR + ++VVL+ R + L
Sbjct: 1836 RHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRD 1895
Query: 308 QVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQ 367
Q+ V++L+ +L+ E S+ + + E ++ R+ +
Sbjct: 1896 QLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1955
Query: 368 SDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEE 402
+ +R + Q+FR EG ASDEE E +
Sbjct: 1956 GPLTFTTRTV----RQVFRLEEG-VASDEEAEEAQ 1985
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 45.4 bits (106), Expect = 1e-04
Identities = 111/432 (25%), Positives = 166/432 (38%), Gaps = 80/432 (18%)
Query: 196 DCERVARL--EEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPE-- 251
+ ERVAR E++ L E +E LR L+ + A Q K + E+ E
Sbjct: 1145 ESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEET 1204
Query: 252 ----AAVRELRQAQG-ALAAAEARAGRLRRGQA--EVRRRAEEARQVVLRSLHRVRELEA 304
AAV+ELRQ G AL + + RRG+ E R A EA LR+ + L+
Sbjct: 1205 RIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA--ELSSLQT 1262
Query: 305 LAQQVPGLQRWVRRLEAELQRY--RSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTP 362
Q+ G QR RRLE +LQ R+ D + + A ++ +G + +
Sbjct: 1263 ARQE--GEQR-RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1319
Query: 363 EGAWQSDSSSGSRALDEVDEQL-------------FRSVEGQAASDEEEVEEERWQEEKK 409
+ SS L + E L R++E +AA E++EEE E+
Sbjct: 1320 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER- 1378
Query: 410 TPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRT 469
E +T A+LS R R +++ G LEA
Sbjct: 1379 -AGRELQTAQAQLSEWRRRQEEEA--------------------GALEA----------- 1406
Query: 470 QGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSL-LEEKLVDVLQLLQRLR 528
G R E EA Q+ E+ E + +E R RL L++ +D+ Q Q +
Sbjct: 1407 -GEEARRRAAREAEALTQRLAEKTE----TVDRLERGRRRLQQELDDATMDLEQQRQLVS 1461
Query: 529 DLNISKRALGKIL-------LSTLDAFRDPTHEGRPSPAAILD---ALHQALAACQLLRR 578
L +R ++L L ++ EGR A L AL + A + L R
Sbjct: 1462 TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELER 1521
Query: 579 QPSAPASAAAAL 590
Q A + AL
Sbjct: 1522 QNRALRAELEAL 1533
Score = 41.6 bits (96), Expect = 0.002
Identities = 102/463 (22%), Positives = 166/463 (35%), Gaps = 91/463 (19%)
Query: 199 RVARLEEENSSLRELVEDLRAALQSSDARCLALQVGL--WK----SQASTHEMGHGGPEA 252
RV +E E + LRE +E+ AA + + Q L W+ +A E G
Sbjct: 1354 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1413
Query: 253 AVRELRQAQGALAAAEARAGRLRRGQ---------------------------------- 278
A RE LA RL RG+
Sbjct: 1414 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1473
Query: 279 -----------AEVRRRAE-EARQVVLRSLHRVRELEALAQQVPGLQRWVRRLEAELQRY 326
E R RAE E R+ R+L R LE + L+R R L AEL+
Sbjct: 1474 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1533
Query: 327 RSEDSQL------------PTPQLAN------PEPGDKSNEPEDAGTRDPDPTPEGAWQS 368
S + Q AN E D+ EDA R + T + A ++
Sbjct: 1534 LSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR-LEVTVQ-ALKT 1591
Query: 369 DSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGR 428
+ DE E+ R + Q E E +EER +++T A A+ L G
Sbjct: 1592 QHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER---KQRTLAVAARKKL------EGE 1642
Query: 429 CDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQ 488
++ A+ M G G L +++A + L ++ + + E+E +
Sbjct: 1643 LEELKAQ--MASAGQ-GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1699
Query: 489 KVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNISKRAL---GKILLSTL 545
K E E LRL+ ++ ++R R +++ ++ + + N+SK A+ + L L
Sbjct: 1700 KGLEAEVLRLQEELAASDRARRQAQQDR----DEMADEVANGNLSKAAILEEKRQLEGRL 1755
Query: 546 DAFRDPTHEGRPSPAAILDALHQALAACQLLRRQPSAPASAAA 588
+ E + + + D + L + L + SA S +A
Sbjct: 1756 GQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA 1798
Score = 36.2 bits (82), Expect = 0.088
Identities = 91/338 (26%), Positives = 132/338 (39%), Gaps = 85/338 (25%)
Query: 202 RLEEENSSLRELV-------EDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAV 254
RL+ E+S L+E + E+LRA L + LQ L +++ GG A +
Sbjct: 1076 RLDGESSELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAE------DEGGARAQL 1126
Query: 255 -RELRQAQGALAAA--EARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPG 311
+ LR+AQ ALA A + + R+ R +AE +RR LR ELE
Sbjct: 1127 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-----ELEDTLDSTNA 1181
Query: 312 LQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSS 371
Q + E E+ + K+ E E TR E A Q
Sbjct: 1182 QQELRSKREQEVTELK------------------KTLEEE---TR----IHEAAVQELRQ 1216
Query: 372 SGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDD 431
+AL E+ EQL ++ G+ A W++ + AE L A LSS
Sbjct: 1217 RHGQALGELAEQLEQARRGKGA----------WEKTRLALEAEVSELRAELSSL------ 1260
Query: 432 QTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVE 491
QTA + G L EL+ L E G G R +E +LQ+
Sbjct: 1261 QTARQ--------EGEQRRRRL-ELQ-----LQEVQGRAGDGER--ARAEAAEKLQRAQA 1304
Query: 492 ENEHLRLELQMVETERVR----LSLLEEKLVDVLQLLQ 525
E E++ L E++ +R LS E +L D +LLQ
Sbjct: 1305 ELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1342
Score = 33.5 bits (75), Expect = 0.57
Identities = 71/313 (22%), Positives = 119/313 (38%), Gaps = 64/313 (20%)
Query: 251 EAAVRELRQAQGALAAAEARAGRLR---RGQAEVRRRAEEAR----------QVVLRSLH 297
+ + RE+ + QG +A E RL R +AE+ AEE R ++V+ L
Sbjct: 886 QQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELE 945
Query: 298 -RVRELEALAQQV----PGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPED 352
RV E E ++Q+ LQ+ ++ LEA L+ +L ++ K E
Sbjct: 946 ARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE--- 1002
Query: 353 AGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVE------------ 400
+ D +S ++ E QAA +EE+V+
Sbjct: 1003 ----------DLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT 1052
Query: 401 ----EERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGEL 456
E+R ++E+K E + L RL +Q E+ EL
Sbjct: 1053 IADMEDRLRKEEK-GRQELEKLKRRLDGESSELQEQMVEQ-------------QQRAEEL 1098
Query: 457 EACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQM-VETERVRLSLLEE 515
A + E+L Q R A+L + + E + E Q +E+ERV + E+
Sbjct: 1099 RAQLGRKEEEL--QAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEK 1156
Query: 516 KLVDVLQLLQRLR 528
+ D+ + L+ LR
Sbjct: 1157 QRRDLGEELEALR 1169
Score = 30.0 bits (66), Expect = 6.3
Identities = 63/275 (22%), Positives = 106/275 (38%), Gaps = 44/275 (16%)
Query: 166 LSEHIETQIRLRRPRRRRRPPCAPGPDSGPDCERVARLEEENS---SLRELVEDLRAALQ 222
L E + R RR ++ R A +G + + A LEE+ L +L E+L
Sbjct: 1709 LQEELAASDRARRQAQQDRDEMADEVANG-NLSKAAILEEKRQLEGRLGQLEEELEEEQS 1767
Query: 223 SSDA-----RCLALQVGLWKSQASTHEM----GHGGPEAAVRELRQAQGAL----AAAEA 269
+S+ R L LQV ++ S G + R++++ +G L A A A
Sbjct: 1768 NSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARA 1827
Query: 270 R------AGRLRRGQAE----------------VRRRAEEARQVVLRSLHRVRELEALAQ 307
R A + QAE VRR + ++VVL+ R + L
Sbjct: 1828 RHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRD 1887
Query: 308 QVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQ 367
Q+ V++L+ +L+ E S+ + + E ++ R+ +
Sbjct: 1888 QLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1947
Query: 368 SDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEE 402
+ +R + Q+FR EG ASDEE E +
Sbjct: 1948 GPLTFTTRTV----RQVFRLEEG-VASDEEAEEAQ 1977
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 45.4 bits (106), Expect = 1e-04
Identities = 111/432 (25%), Positives = 166/432 (38%), Gaps = 80/432 (18%)
Query: 196 DCERVARL--EEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPE-- 251
+ ERVAR E++ L E +E LR L+ + A Q K + E+ E
Sbjct: 1186 ESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEET 1245
Query: 252 ----AAVRELRQAQG-ALAAAEARAGRLRRGQA--EVRRRAEEARQVVLRSLHRVRELEA 304
AAV+ELRQ G AL + + RRG+ E R A EA LR+ + L+
Sbjct: 1246 RIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRA--ELSSLQT 1303
Query: 305 LAQQVPGLQRWVRRLEAELQRY--RSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTP 362
Q+ G QR RRLE +LQ R+ D + + A ++ +G + +
Sbjct: 1304 ARQE--GEQR-RRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESK 1360
Query: 363 EGAWQSDSSSGSRALDEVDEQL-------------FRSVEGQAASDEEEVEEERWQEEKK 409
+ SS L + E L R++E +AA E++EEE E+
Sbjct: 1361 TIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER- 1419
Query: 410 TPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRT 469
E +T A+LS R R +++ G LEA
Sbjct: 1420 -AGRELQTAQAQLSEWRRRQEEEA--------------------GALEA----------- 1447
Query: 470 QGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSL-LEEKLVDVLQLLQRLR 528
G R E EA Q+ E+ E + +E R RL L++ +D+ Q Q +
Sbjct: 1448 -GEEARRRAAREAEALTQRLAEKTE----TVDRLERGRRRLQQELDDATMDLEQQRQLVS 1502
Query: 529 DLNISKRALGKIL-------LSTLDAFRDPTHEGRPSPAAILD---ALHQALAACQLLRR 578
L +R ++L L ++ EGR A L AL + A + L R
Sbjct: 1503 TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELER 1562
Query: 579 QPSAPASAAAAL 590
Q A + AL
Sbjct: 1563 QNRALRAELEAL 1574
Score = 41.6 bits (96), Expect = 0.002
Identities = 102/463 (22%), Positives = 166/463 (35%), Gaps = 91/463 (19%)
Query: 199 RVARLEEENSSLRELVEDLRAALQSSDARCLALQVGL--WK----SQASTHEMGHGGPEA 252
RV +E E + LRE +E+ AA + + Q L W+ +A E G
Sbjct: 1395 RVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR 1454
Query: 253 AVRELRQAQGALAAAEARAGRLRRGQ---------------------------------- 278
A RE LA RL RG+
Sbjct: 1455 AAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQL 1514
Query: 279 -----------AEVRRRAE-EARQVVLRSLHRVRELEALAQQVPGLQRWVRRLEAELQRY 326
E R RAE E R+ R+L R LE + L+R R L AEL+
Sbjct: 1515 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1574
Query: 327 RSEDSQL------------PTPQLAN------PEPGDKSNEPEDAGTRDPDPTPEGAWQS 368
S + Q AN E D+ EDA R + T + A ++
Sbjct: 1575 LSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLR-LEVTVQ-ALKT 1632
Query: 369 DSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGR 428
+ DE E+ R + Q E E +EER +++T A A+ L G
Sbjct: 1633 QHERDLQGRDEAGEERRRQLAKQLRDAEVERDEER---KQRTLAVAARKKL------EGE 1683
Query: 429 CDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQ 488
++ A+ M G G L +++A + L ++ + + E+E +
Sbjct: 1684 LEELKAQ--MASAGQ-GKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRL 1740
Query: 489 KVEENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQRLRDLNISKRAL---GKILLSTL 545
K E E LRL+ ++ ++R R +++ ++ + + N+SK A+ + L L
Sbjct: 1741 KGLEAEVLRLQEELAASDRARRQAQQDR----DEMADEVANGNLSKAAILEEKRQLEGRL 1796
Query: 546 DAFRDPTHEGRPSPAAILDALHQALAACQLLRRQPSAPASAAA 588
+ E + + + D + L + L + SA S +A
Sbjct: 1797 GQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSA 1839
Score = 36.2 bits (82), Expect = 0.088
Identities = 91/338 (26%), Positives = 132/338 (39%), Gaps = 85/338 (25%)
Query: 202 RLEEENSSLRELV-------EDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAV 254
RL+ E+S L+E + E+LRA L + LQ L +++ GG A +
Sbjct: 1117 RLDGESSELQEQMVEQQQRAEELRAQLGRKEEE---LQAALARAE------DEGGARAQL 1167
Query: 255 -RELRQAQGALAAA--EARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPG 311
+ LR+AQ ALA A + + R+ R +AE +RR LR ELE
Sbjct: 1168 LKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRG-----ELEDTLDSTNA 1222
Query: 312 LQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSS 371
Q + E E+ + K+ E E TR E A Q
Sbjct: 1223 QQELRSKREQEVTELK------------------KTLEEE---TR----IHEAAVQELRQ 1257
Query: 372 SGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDD 431
+AL E+ EQL ++ G+ A W++ + AE L A LSS
Sbjct: 1258 RHGQALGELAEQLEQARRGKGA----------WEKTRLALEAEVSELRAELSSL------ 1301
Query: 432 QTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVE 491
QTA + G L EL+ L E G G R +E +LQ+
Sbjct: 1302 QTARQ--------EGEQRRRRL-ELQ-----LQEVQGRAGDGER--ARAEAAEKLQRAQA 1345
Query: 492 ENEHLRLELQMVETERVR----LSLLEEKLVDVLQLLQ 525
E E++ L E++ +R LS E +L D +LLQ
Sbjct: 1346 ELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1383
Score = 33.5 bits (75), Expect = 0.57
Identities = 71/313 (22%), Positives = 119/313 (38%), Gaps = 64/313 (20%)
Query: 251 EAAVRELRQAQGALAAAEARAGRLR---RGQAEVRRRAEEAR----------QVVLRSLH 297
+ + RE+ + QG +A E RL R +AE+ AEE R ++V+ L
Sbjct: 927 QQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELE 986
Query: 298 -RVRELEALAQQV----PGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPED 352
RV E E ++Q+ LQ+ ++ LEA L+ +L ++ K E
Sbjct: 987 ARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEE--- 1043
Query: 353 AGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVE------------ 400
+ D +S ++ E QAA +EE+V+
Sbjct: 1044 ----------DLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT 1093
Query: 401 ----EERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGEL 456
E+R ++E+K E + L RL +Q E+ EL
Sbjct: 1094 IADMEDRLRKEEK-GRQELEKLKRRLDGESSELQEQMVEQ-------------QQRAEEL 1139
Query: 457 EACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQM-VETERVRLSLLEE 515
A + E+L Q R A+L + + E + E Q +E+ERV + E+
Sbjct: 1140 RAQLGRKEEEL--QAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEK 1197
Query: 516 KLVDVLQLLQRLR 528
+ D+ + L+ LR
Sbjct: 1198 QRRDLGEELEALR 1210
Score = 30.0 bits (66), Expect = 6.3
Identities = 63/275 (22%), Positives = 106/275 (38%), Gaps = 44/275 (16%)
Query: 166 LSEHIETQIRLRRPRRRRRPPCAPGPDSGPDCERVARLEEENS---SLRELVEDLRAALQ 222
L E + R RR ++ R A +G + + A LEE+ L +L E+L
Sbjct: 1750 LQEELAASDRARRQAQQDRDEMADEVANG-NLSKAAILEEKRQLEGRLGQLEEELEEEQS 1808
Query: 223 SSDA-----RCLALQVGLWKSQASTHEM----GHGGPEAAVRELRQAQGAL----AAAEA 269
+S+ R L LQV ++ S G + R++++ +G L A A A
Sbjct: 1809 NSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARA 1868
Query: 270 R------AGRLRRGQAE----------------VRRRAEEARQVVLRSLHRVRELEALAQ 307
R A + QAE VRR + ++VVL+ R + L
Sbjct: 1869 RHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRD 1928
Query: 308 QVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQ 367
Q+ V++L+ +L+ E S+ + + E ++ R+ +
Sbjct: 1929 QLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1988
Query: 368 SDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEE 402
+ +R + Q+FR EG ASDEE E +
Sbjct: 1989 GPLTFTTRTV----RQVFRLEEG-VASDEEAEEAQ 2018
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 45.4 bits (106), Expect = 1e-04
Identities = 54/211 (25%), Positives = 88/211 (41%), Gaps = 22/211 (10%)
Query: 201 ARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVRELRQA 260
AR E E RE+ + + +D CL ++ + E R++R+
Sbjct: 133 ARREWERQKRREMAREHSRRERGNDGVCL------FRDRLEQLER----KRERERKMREQ 182
Query: 261 QGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQRWVRRL- 319
Q E R + R +AE RR+ EAR+ V S H E + +V W R
Sbjct: 183 Q-----KEQREQKERERRAEERRKEREARREV--SAHHRTMREDYSDKVKA-SHWSRSPP 234
Query: 320 EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALDE 379
+R+ D + P + E D ++ +D D + A S + SGS + +E
Sbjct: 235 RPPRERFELGDGRKPVKE-EKMEERDLLSDLQDIS--DSERKTSSAESSSAESGSGSEEE 291
Query: 380 VDEQLFRSVEGQAASDEEEVEEERWQEEKKT 410
+E+ EG + + EE EEE +EE++T
Sbjct: 292 EEEEEEEEEEGSTSEESEEEEEEEEEEEEET 322
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 45.1 bits (105), Expect = 2e-04
Identities = 69/344 (20%), Positives = 136/344 (39%), Gaps = 36/344 (10%)
Query: 223 SSDARCLALQVGLWKSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVR 282
S + L QV + + T + +A ++EL + + L + +++ QA+++
Sbjct: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
Query: 283 RRAEEARQVVLRSLH-RVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANP 341
RR +EAR+ +L + R +E +A ++ + L+ E+ R+E Q L
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIE--MATLDKEMAEERAESLQQEVEAL--- 194
Query: 342 EPGDKSNEPEDAGTRDPDPTPEGAWQ--SDSSSGSRALDEVDEQ-------LFRSVEGQA 392
E D T D + + SD ++ S L +++EQ L R + +
Sbjct: 195 ------KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 248
Query: 393 ASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHT 452
+ +E V+ ++ E+K + RL + + E G
Sbjct: 249 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 308
Query: 453 LGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE-----HLRLELQM----V 503
L + + V +LR T+G E E+ +++EN LR +L M V
Sbjct: 309 LTDRNLNLEEKVRELR------ETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
Query: 504 ETERVRLSLLEEKLVDVLQLLQRLRDLNISKRALGKILLSTLDA 547
+ R+ +E + D Q +++ R L + + + L + +A
Sbjct: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA 406
Score = 30.8 bits (68), Expect = 3.7
Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 16/144 (11%)
Query: 190 GPDSGPDCERVARLEEENSSLRELVEDLRAALQSSDARCLALQ---------VGLWKSQA 240
G D ++ +LEE+N+ L++ + +R S + LQ + + + Q
Sbjct: 216 GSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR 275
Query: 241 STHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVR 300
+ E+ + EL++ A AE L + + E R+ V
Sbjct: 276 ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRET-------VG 328
Query: 301 ELEALAQQVPGLQRWVRRLEAELQ 324
+LEA+ + LQ R E EL+
Sbjct: 329 DLEAMNEMNDELQENARETELELR 352
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 45.1 bits (105), Expect = 2e-04
Identities = 69/344 (20%), Positives = 136/344 (39%), Gaps = 36/344 (10%)
Query: 223 SSDARCLALQVGLWKSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVR 282
S + L QV + + T + +A ++EL + + L + +++ QA+++
Sbjct: 194 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 253
Query: 283 RRAEEARQVVLRSLH-RVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANP 341
RR +EAR+ +L + R +E +A ++ + L+ E+ R+E Q L
Sbjct: 254 RRLKEARKEAKEALEAKERYMEEMADTADAIE--MATLDKEMAEERAESLQQEVEAL--- 308
Query: 342 EPGDKSNEPEDAGTRDPDPTPEGAWQ--SDSSSGSRALDEVDEQ-------LFRSVEGQA 392
E D T D + + SD ++ S L +++EQ L R + +
Sbjct: 309 ------KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 362
Query: 393 ASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHT 452
+ +E V+ ++ E+K + RL + + E G
Sbjct: 363 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 422
Query: 453 LGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE-----HLRLELQM----V 503
L + + V +LR T+G E E+ +++EN LR +L M V
Sbjct: 423 LTDRNLNLEEKVRELR------ETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 476
Query: 504 ETERVRLSLLEEKLVDVLQLLQRLRDLNISKRALGKILLSTLDA 547
+ R+ +E + D Q +++ R L + + + L + +A
Sbjct: 477 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA 520
Score = 30.8 bits (68), Expect = 3.7
Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 16/144 (11%)
Query: 190 GPDSGPDCERVARLEEENSSLRELVEDLRAALQSSDARCLALQ---------VGLWKSQA 240
G D ++ +LEE+N+ L++ + +R S + LQ + + + Q
Sbjct: 330 GSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR 389
Query: 241 STHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVR 300
+ E+ + EL++ A AE L + + E R+ V
Sbjct: 390 ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRET-------VG 442
Query: 301 ELEALAQQVPGLQRWVRRLEAELQ 324
+LEA+ + LQ R E EL+
Sbjct: 443 DLEAMNEMNDELQENARETELELR 466
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 45.1 bits (105), Expect = 2e-04
Identities = 69/344 (20%), Positives = 136/344 (39%), Gaps = 36/344 (10%)
Query: 223 SSDARCLALQVGLWKSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVR 282
S + L QV + + T + +A ++EL + + L + +++ QA+++
Sbjct: 80 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 139
Query: 283 RRAEEARQVVLRSLH-RVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANP 341
RR +EAR+ +L + R +E +A ++ + L+ E+ R+E Q L
Sbjct: 140 RRLKEARKEAKEALEAKERYMEEMADTADAIE--MATLDKEMAEERAESLQQEVEAL--- 194
Query: 342 EPGDKSNEPEDAGTRDPDPTPEGAWQ--SDSSSGSRALDEVDEQ-------LFRSVEGQA 392
E D T D + + SD ++ S L +++EQ L R + +
Sbjct: 195 ------KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 248
Query: 393 ASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHT 452
+ +E V+ ++ E+K + RL + + E G
Sbjct: 249 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 308
Query: 453 LGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE-----HLRLELQM----V 503
L + + V +LR T+G E E+ +++EN LR +L M V
Sbjct: 309 LTDRNLNLEEKVRELR------ETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 362
Query: 504 ETERVRLSLLEEKLVDVLQLLQRLRDLNISKRALGKILLSTLDA 547
+ R+ +E + D Q +++ R L + + + L + +A
Sbjct: 363 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA 406
Score = 30.8 bits (68), Expect = 3.7
Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 16/144 (11%)
Query: 190 GPDSGPDCERVARLEEENSSLRELVEDLRAALQSSDARCLALQ---------VGLWKSQA 240
G D ++ +LEE+N+ L++ + +R S + LQ + + + Q
Sbjct: 216 GSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR 275
Query: 241 STHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVR 300
+ E+ + EL++ A AE L + + E R+ V
Sbjct: 276 ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRET-------VG 328
Query: 301 ELEALAQQVPGLQRWVRRLEAELQ 324
+LEA+ + LQ R E EL+
Sbjct: 329 DLEAMNEMNDELQENARETELELR 352
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 45.1 bits (105), Expect = 2e-04
Identities = 69/344 (20%), Positives = 136/344 (39%), Gaps = 36/344 (10%)
Query: 223 SSDARCLALQVGLWKSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVR 282
S + L QV + + T + +A ++EL + + L + +++ QA+++
Sbjct: 214 SKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQ 273
Query: 283 RRAEEARQVVLRSLH-RVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANP 341
RR +EAR+ +L + R +E +A ++ + L+ E+ R+E Q L
Sbjct: 274 RRLKEARKEAKEALEAKERYMEEMADTADAIE--MATLDKEMAEERAESLQQEVEAL--- 328
Query: 342 EPGDKSNEPEDAGTRDPDPTPEGAWQ--SDSSSGSRALDEVDEQ-------LFRSVEGQA 392
E D T D + + SD ++ S L +++EQ L R + +
Sbjct: 329 ------KERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 382
Query: 393 ASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHT 452
+ +E V+ ++ E+K + RL + + E G
Sbjct: 383 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 442
Query: 453 LGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE-----HLRLELQM----V 503
L + + V +LR T+G E E+ +++EN LR +L M V
Sbjct: 443 LTDRNLNLEEKVRELR------ETVGDLEAMNEMNDELQENARETELELREQLDMAGARV 496
Query: 504 ETERVRLSLLEEKLVDVLQLLQRLRDLNISKRALGKILLSTLDA 547
+ R+ +E + D Q +++ R L + + + L + +A
Sbjct: 497 REAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEA 540
Score = 30.8 bits (68), Expect = 3.7
Identities = 31/144 (21%), Positives = 56/144 (38%), Gaps = 16/144 (11%)
Query: 190 GPDSGPDCERVARLEEENSSLRELVEDLRAALQSSDARCLALQ---------VGLWKSQA 240
G D ++ +LEE+N+ L++ + +R S + LQ + + + Q
Sbjct: 350 GSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQR 409
Query: 241 STHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVR 300
+ E+ + EL++ A AE L + + E R+ V
Sbjct: 410 ERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRET-------VG 462
Query: 301 ELEALAQQVPGLQRWVRRLEAELQ 324
+LEA+ + LQ R E EL+
Sbjct: 463 DLEAMNEMNDELQENARETELELR 486
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/157 (28%), Positives = 71/157 (45%), Gaps = 12/157 (7%)
Query: 255 RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQR 314
R++R+ Q E R + R +AE RR+ EAR+ V S H E + +V
Sbjct: 167 RKMREQQ-----KEQREQKERERRAEERRKEREARREV--SAHHRTMREDYSDKVKA-SH 218
Query: 315 WVRRL-EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSG 373
W R +R+ D + P + E D ++ +D D + A S + SG
Sbjct: 219 WSRSPPRPPRERFELGDGRKPVKE-EKMEERDLLSDLQDIS--DSERKTSSAESSSAESG 275
Query: 374 SRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKT 410
S + +E +E+ EG + + EE EEE +EE++T
Sbjct: 276 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 312
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/157 (28%), Positives = 71/157 (45%), Gaps = 12/157 (7%)
Query: 255 RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQR 314
R++R+ Q E R + R +AE RR+ EAR+ V S H E + +V
Sbjct: 177 RKMREQQ-----KEQREQKERERRAEERRKEREARREV--SAHHRTMREDYSDKVKA-SH 228
Query: 315 WVRRL-EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSG 373
W R +R+ D + P + E D ++ +D D + A S + SG
Sbjct: 229 WSRSPPRPPRERFELGDGRKPVKE-EKMEERDLLSDLQDIS--DSERKTSSAESSSAESG 285
Query: 374 SRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKT 410
S + +E +E+ EG + + EE EEE +EE++T
Sbjct: 286 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 322
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/157 (28%), Positives = 71/157 (45%), Gaps = 12/157 (7%)
Query: 255 RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQR 314
R++R+ Q E R + R +AE RR+ EAR+ V S H E + +V
Sbjct: 168 RKMREQQ-----KEQREQKERERRAEERRKEREARREV--SAHHRTMREDYSDKVKA-SH 219
Query: 315 WVRRL-EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSG 373
W R +R+ D + P + E D ++ +D D + A S + SG
Sbjct: 220 WSRSPPRPPRERFELGDGRKPVKE-EKMEERDLLSDLQDIS--DSERKTSSAESSSAESG 276
Query: 374 SRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKT 410
S + +E +E+ EG + + EE EEE +EE++T
Sbjct: 277 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 313
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/157 (28%), Positives = 71/157 (45%), Gaps = 12/157 (7%)
Query: 255 RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQR 314
R++R+ Q E R + R +AE RR+ EAR+ V S H E + +V
Sbjct: 145 RKMREQQ-----KEQREQKERERRAEERRKEREARREV--SAHHRTMREDYSDKVKA-SH 196
Query: 315 WVRRL-EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSG 373
W R +R+ D + P + E D ++ +D D + A S + SG
Sbjct: 197 WSRSPPRPPRERFELGDGRKPVKE-EKMEERDLLSDLQDIS--DSERKTSSAESSSAESG 253
Query: 374 SRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKT 410
S + +E +E+ EG + + EE EEE +EE++T
Sbjct: 254 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 290
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/157 (28%), Positives = 71/157 (45%), Gaps = 12/157 (7%)
Query: 255 RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQR 314
R++R+ Q E R + R +AE RR+ EAR+ V S H E + +V
Sbjct: 134 RKMREQQ-----KEQREQKERERRAEERRKEREARREV--SAHHRTMREDYSDKVKA-SH 185
Query: 315 WVRRL-EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSG 373
W R +R+ D + P + E D ++ +D D + A S + SG
Sbjct: 186 WSRSPPRPPRERFELGDGRKPVKE-EKMEERDLLSDLQDIS--DSERKTSSAESSSAESG 242
Query: 374 SRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKT 410
S + +E +E+ EG + + EE EEE +EE++T
Sbjct: 243 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 279
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 45.1 bits (105), Expect = 2e-04
Identities = 44/157 (28%), Positives = 71/157 (45%), Gaps = 12/157 (7%)
Query: 255 RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQR 314
R++R+ Q E R + R +AE RR+ EAR+ V S H E + +V
Sbjct: 179 RKMREQQ-----KEQREQKERERRAEERRKEREARREV--SAHHRTMREDYSDKVKA-SH 230
Query: 315 WVRRL-EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSG 373
W R +R+ D + P + E D ++ +D D + A S + SG
Sbjct: 231 WSRSPPRPPRERFELGDGRKPVKE-EKMEERDLLSDLQDIS--DSERKTSSAESSSAESG 287
Query: 374 SRALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKT 410
S + +E +E+ EG + + EE EEE +EE++T
Sbjct: 288 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 324
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 44.7 bits (104), Expect = 2e-04
Identities = 87/389 (22%), Positives = 144/389 (37%), Gaps = 59/389 (15%)
Query: 198 ERVARLEEE----NSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAA 253
E V R EE R + E+L+ QSS+A A QA E E
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA-----RQAEAAERSRLRIEEE 1453
Query: 254 VRELRQ-----------AQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVREL 302
+R +R A+G L A ARA + + + AE R+ V R R+
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 303 E--------ALAQQVPGLQRWVRRLE---------------AELQRYRSEDSQLPTPQLA 339
E A A+ QR ++ LE AE++R R L T Q
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-- 1571
Query: 340 NPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEV 399
+ + + A + E + Q + + ++ +E + + + E + A +E E
Sbjct: 1572 --RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Query: 400 EEERWQ---EEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGEL 456
E ERWQ E +A+ + + S + + Q E G + +
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR 1687
Query: 457 EACIAMLVEQLR-TQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEE 515
E L +Q + +G + L +E L+ + E+ E R Q++E E L+ L+
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR---QLLEEE---LARLQR 1741
Query: 516 KLVDVLQLLQRLRDLNISKRALGKILLST 544
+ Q Q L RA ++LL++
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Score = 40.4 bits (93), Expect = 0.005
Identities = 82/334 (24%), Positives = 122/334 (36%), Gaps = 33/334 (9%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
E +ARL+ E ++ + ++L A L A+ A L S+A E E + + L
Sbjct: 1734 EELARLQREAAAATQKRQELEAEL----AKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQRWVR 317
G A RLR E +R+ + A + R R LA+++ + R
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATR 1847
Query: 318 -RLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRA 376
+ EAE+ E +LA E + E A D E Q +S S
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKASDSEL 1906
Query: 377 LDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEK 436
E + L Q EEE+ + EK AA L L R +D K
Sbjct: 1907 --ERQKGLVEDTLRQRRQVEEEILALKASFEKA--AAGKAELELELGRIRSNAEDTLRSK 1962
Query: 437 LMTYFGHFGGANHAHTLGELEACIAMLV---EQLRTQGCGGRTLGT--SEEEAELQQKVE 491
ELEA + E+ R + R + +EEEA Q+K
Sbjct: 1963 EQA---------------ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 492 ENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQ 525
E RL+ ++ E R+R E++ LQL Q
Sbjct: 2008 LEEVERLKAKVEEARRLR-ERAEQESARQLQLAQ 2040
Score = 39.7 bits (91), Expect = 0.008
Identities = 80/321 (24%), Positives = 125/321 (38%), Gaps = 63/321 (19%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
ER+ RL E+ + R +E+ +AA +D Q L K+ S E G E +R+
Sbjct: 1864 ERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQ--LRKASDSELERQKGLVEDTLRQR 1920
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEAR---QVVLRSLHRVRELEALAQQVPGLQR 314
RQ + + A +A + G+AE+ R + LRS + ELEA Q
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQ------- 1972
Query: 315 WVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGS 374
R+L AE +R R E + LA E + +
Sbjct: 1973 --RQLAAEEERRRREAEERVQKSLAAEEEAARQRKA------------------------ 2006
Query: 375 RALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTA 434
AL+EV E+L VE +A E E+E ++ + A K L Q
Sbjct: 2007 -ALEEV-ERLKAKVE-EARRLRERAEQESARQLQLAQEAAQKRL-------------QAE 2050
Query: 435 EKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE 494
EK + TL + ++ +++QLR + R EEA +Q + E +
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 495 HLRLELQMVETERVRLSLLEE 515
R Q+ E ER++ S E+
Sbjct: 2107 SRR---QVEEAERLKQSAEEQ 2124
Score = 38.9 bits (89), Expect = 0.014
Identities = 92/442 (20%), Positives = 162/442 (36%), Gaps = 44/442 (9%)
Query: 127 EEARLALRAEPPELTFRQFHA-RLCGYFGTRAGPRLPRGALSEHIETQIRLRRPRRRRRP 185
EEAR+ E + + A RL +A R A +E + + RR +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 186 PCAPGPDSGPDCERVARLEEENSSLRELVE------DLRAALQSSDARCLALQVGLWKSQ 239
A D E + +LR+ + LR L+ +D + L L + +
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Query: 240 ASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRV 299
A E A R+ Q + L + + L + +A + E R ++LR
Sbjct: 2214 AEATE--------AARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNT 2262
Query: 300 -RELEALAQQVPGLQRWVRRL-----EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDA 353
R L+ A+++ + RL EA R +E+ LA +K ++A
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 354 GTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQE-EKKTPA 412
+ + + +R L E EQ+ + + + + +E ER ++ E A
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 413 AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGC 472
K +A +S + R ++ A++ G H L E + +++ Q
Sbjct: 2383 ERLKLRVAEMSRAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Query: 473 G------GRTLGTSEEEAE--------LQQKVEENEHLRLELQMVETERVRLSLLEEKLV 518
+ E E E LQ K EE + ++ E + ET+ ++ S L EK
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-- 2499
Query: 519 DVLQLLQRLRDLNISKRALGKI 540
LLQR R + K L ++
Sbjct: 2500 --DSLLQRERFIEQEKAKLEQL 2519
Score = 37.4 bits (85), Expect = 0.040
Identities = 83/404 (20%), Positives = 144/404 (35%), Gaps = 77/404 (19%)
Query: 196 DCERVARLEEENSSLRE------LVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGG 249
+ E +R++ E + RE +E+LR + ++ R +V + E
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 250 PEAAV---------------RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLR 294
EA + R L++ A+A A R + QAE R EEA + + R
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 295 SLHRVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ E L Q + + +AE ++ + E + + E + E +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 355 TRDPDPTPEGAWQ-------------SDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEE 401
EG Q +++ G + ++E+L R AA+ ++ E
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 402 ERWQEEKKTPAAEAKTLL---ARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEA 458
E E AE + LL AR +++ ++L G F L E A
Sbjct: 1754 E---AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF------RELAEEAA 1804
Query: 459 CIAMLVEQLRTQ------------------------GCGGRTLGTSEEEAELQQKVEENE 494
+ L E+ + Q G T +E E L++K ENE
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864
Query: 495 HLRLELQMVETERVRLSLLEEKL----VDVLQLLQRLRDLNISK 534
LR ++ E E + LEE+ D+ + L +LR + S+
Sbjct: 1865 RLR---RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905
Score = 33.9 bits (76), Expect = 0.44
Identities = 78/345 (22%), Positives = 133/345 (38%), Gaps = 51/345 (14%)
Query: 196 DCERVARLEEENSSLRELVED-----LRAALQSSDARCLA---------------LQVGL 235
+ ER+ EE LRE E L+ A +++ R A LQ L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 236 WKSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRS 295
+ Q+ ++ G EAA R +A+ A AE A A+ RR+ EEA ++
Sbjct: 2070 QQEQSVLDQL-RGEAEAARRAAEEAEEARVQAEREA-------AQSRRQVEEAERL---K 2118
Query: 296 LHRVRELEALAQQVPGLQRWVRRLEAE-LQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ +A AQ ++ + E E +R ++E + L Q A+ E E
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 355 TRDPDPTPEGA---WQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEE------RWQ 405
+ E Q + + + L + + Q ++ +AA +VEEE + +
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Query: 406 EEKKTPA---AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAM 462
E K A AE + L+ R R + AEK+ A A L + A A
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV------AEEAARL-SVAAQEAA 2291
Query: 463 LVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETER 507
+ QL + + + E Q V+E L+ E ++++ ++
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Score = 30.8 bits (68), Expect = 3.7
Identities = 58/242 (23%), Positives = 95/242 (39%), Gaps = 25/242 (10%)
Query: 202 RLEEENSSLRELVEDLRAALQSSDARCLALQVG-LWKSQASTHEMGHGGPEAAVRELRQA 260
RL+ E R V LR L AR A ++ K+QA +G G R +A
Sbjct: 993 RLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG----VARLSAEA 1047
Query: 261 QGALAAAE-ARAGRLRRGQAEVRR-RAEEARQVVLRSLHRVRELEALAQQVPGLQRWVRR 318
+ LA E + A R + E+ + E+ R + L +++ + + + G + +R
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107
Query: 319 LEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALD 378
E +L+ ++ + LP E S + A PT + R
Sbjct: 1108 HEEQLKEAQAVPATLP-----ELEATKASLKKLRAQAEAQQPTFDALRDE-----LRGAQ 1157
Query: 379 EVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLM 438
EV E+L Q E +VE ERW+E + +LA+ + R R +Q +L
Sbjct: 1158 EVGERL------QQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLR 1210
Query: 439 TY 440
Y
Sbjct: 1211 YY 1212
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 44.7 bits (104), Expect = 2e-04
Identities = 87/389 (22%), Positives = 144/389 (37%), Gaps = 59/389 (15%)
Query: 198 ERVARLEEE----NSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAA 253
E V R EE R + E+L+ QSS+A A QA E E
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA-----RQAEAAERSRLRIEEE 1457
Query: 254 VRELRQ-----------AQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVREL 302
+R +R A+G L A ARA + + + AE R+ V R R+
Sbjct: 1458 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517
Query: 303 E--------ALAQQVPGLQRWVRRLE---------------AELQRYRSEDSQLPTPQLA 339
E A A+ QR ++ LE AE++R R L T Q
Sbjct: 1518 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-- 1575
Query: 340 NPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEV 399
+ + + A + E + Q + + ++ +E + + + E + A +E E
Sbjct: 1576 --RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1633
Query: 400 EEERWQ---EEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGEL 456
E ERWQ E +A+ + + S + + Q E G + +
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR 1691
Query: 457 EACIAMLVEQLR-TQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEE 515
E L +Q + +G + L +E L+ + E+ E R Q++E E L+ L+
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR---QLLEEE---LARLQR 1745
Query: 516 KLVDVLQLLQRLRDLNISKRALGKILLST 544
+ Q Q L RA ++LL++
Sbjct: 1746 EAAAATQKRQELEAELAKVRAEMEVLLAS 1774
Score = 40.4 bits (93), Expect = 0.005
Identities = 82/334 (24%), Positives = 122/334 (36%), Gaps = 33/334 (9%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
E +ARL+ E ++ + ++L A L A+ A L S+A E E + + L
Sbjct: 1738 EELARLQREAAAATQKRQELEAEL----AKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1793
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQRWVR 317
G A RLR E +R+ + A + R R LA+++ + R
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATR 1851
Query: 318 -RLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRA 376
+ EAE+ E +LA E + E A D E Q +S S
Sbjct: 1852 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKASDSEL 1910
Query: 377 LDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEK 436
E + L Q EEE+ + EK AA L L R +D K
Sbjct: 1911 --ERQKGLVEDTLRQRRQVEEEILALKASFEKA--AAGKAELELELGRIRSNAEDTLRSK 1966
Query: 437 LMTYFGHFGGANHAHTLGELEACIAMLV---EQLRTQGCGGRTLGT--SEEEAELQQKVE 491
ELEA + E+ R + R + +EEEA Q+K
Sbjct: 1967 EQA---------------ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2011
Query: 492 ENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQ 525
E RL+ ++ E R+R E++ LQL Q
Sbjct: 2012 LEEVERLKAKVEEARRLR-ERAEQESARQLQLAQ 2044
Score = 39.7 bits (91), Expect = 0.008
Identities = 80/321 (24%), Positives = 125/321 (38%), Gaps = 63/321 (19%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
ER+ RL E+ + R +E+ +AA +D Q L K+ S E G E +R+
Sbjct: 1868 ERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQ--LRKASDSELERQKGLVEDTLRQR 1924
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEAR---QVVLRSLHRVRELEALAQQVPGLQR 314
RQ + + A +A + G+AE+ R + LRS + ELEA Q
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQ------- 1976
Query: 315 WVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGS 374
R+L AE +R R E + LA E + +
Sbjct: 1977 --RQLAAEEERRRREAEERVQKSLAAEEEAARQRKA------------------------ 2010
Query: 375 RALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTA 434
AL+EV E+L VE +A E E+E ++ + A K L Q
Sbjct: 2011 -ALEEV-ERLKAKVE-EARRLRERAEQESARQLQLAQEAAQKRL-------------QAE 2054
Query: 435 EKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE 494
EK + TL + ++ +++QLR + R EEA +Q + E +
Sbjct: 2055 EKAHAFAVQQKEQELQQTLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2110
Query: 495 HLRLELQMVETERVRLSLLEE 515
R Q+ E ER++ S E+
Sbjct: 2111 SRR---QVEEAERLKQSAEEQ 2128
Score = 38.9 bits (89), Expect = 0.014
Identities = 92/442 (20%), Positives = 162/442 (36%), Gaps = 44/442 (9%)
Query: 127 EEARLALRAEPPELTFRQFHA-RLCGYFGTRAGPRLPRGALSEHIETQIRLRRPRRRRRP 185
EEAR+ E + + A RL +A R A +E + + RR +
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157
Query: 186 PCAPGPDSGPDCERVARLEEENSSLRELVE------DLRAALQSSDARCLALQVGLWKSQ 239
A D E + +LR+ + LR L+ +D + L L + +
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2217
Query: 240 ASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRV 299
A E A R+ Q + L + + L + +A + E R ++LR
Sbjct: 2218 AEATE--------AARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNT 2266
Query: 300 -RELEALAQQVPGLQRWVRRL-----EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDA 353
R L+ A+++ + RL EA R +E+ LA +K ++A
Sbjct: 2267 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2326
Query: 354 GTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQE-EKKTPA 412
+ + + +R L E EQ+ + + + + +E ER ++ E A
Sbjct: 2327 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2386
Query: 413 AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGC 472
K +A +S + R ++ A++ G H L E + +++ Q
Sbjct: 2387 ERLKLRVAEMSRAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2445
Query: 473 G------GRTLGTSEEEAE--------LQQKVEENEHLRLELQMVETERVRLSLLEEKLV 518
+ E E E LQ K EE + ++ E + ET+ ++ S L EK
Sbjct: 2446 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-- 2503
Query: 519 DVLQLLQRLRDLNISKRALGKI 540
LLQR R + K L ++
Sbjct: 2504 --DSLLQRERFIEQEKAKLEQL 2523
Score = 37.4 bits (85), Expect = 0.040
Identities = 83/404 (20%), Positives = 144/404 (35%), Gaps = 77/404 (19%)
Query: 196 DCERVARLEEENSSLRE------LVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGG 249
+ E +R++ E + RE +E+LR + ++ R +V + E
Sbjct: 1518 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1577
Query: 250 PEAAV---------------RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLR 294
EA + R L++ A+A A R + QAE R EEA + + R
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Query: 295 SLHRVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ E L Q + + +AE ++ + E + + E + E +
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697
Query: 355 TRDPDPTPEGAWQ-------------SDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEE 401
EG Q +++ G + ++E+L R AA+ ++ E
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 402 ERWQEEKKTPAAEAKTLL---ARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEA 458
E E AE + LL AR +++ ++L G F L E A
Sbjct: 1758 E---AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF------RELAEEAA 1808
Query: 459 CIAMLVEQLRTQ------------------------GCGGRTLGTSEEEAELQQKVEENE 494
+ L E+ + Q G T +E E L++K ENE
Sbjct: 1809 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1868
Query: 495 HLRLELQMVETERVRLSLLEEKL----VDVLQLLQRLRDLNISK 534
LR ++ E E + LEE+ D+ + L +LR + S+
Sbjct: 1869 RLR---RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1909
Score = 33.9 bits (76), Expect = 0.44
Identities = 78/345 (22%), Positives = 133/345 (38%), Gaps = 51/345 (14%)
Query: 196 DCERVARLEEENSSLRELVED-----LRAALQSSDARCLA---------------LQVGL 235
+ ER+ EE LRE E L+ A +++ R A LQ L
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 236 WKSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRS 295
+ Q+ ++ G EAA R +A+ A AE A A+ RR+ EEA ++
Sbjct: 2074 QQEQSVLDQL-RGEAEAARRAAEEAEEARVQAEREA-------AQSRRQVEEAERL---K 2122
Query: 296 LHRVRELEALAQQVPGLQRWVRRLEAE-LQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ +A AQ ++ + E E +R ++E + L Q A+ E E
Sbjct: 2123 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Query: 355 TRDPDPTPEGA---WQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEE------RWQ 405
+ E Q + + + L + + Q ++ +AA +VEEE + +
Sbjct: 2183 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242
Query: 406 EEKKTPA---AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAM 462
E K A AE + L+ R R + AEK+ A A L + A A
Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV------AEEAARL-SVAAQEAA 2295
Query: 463 LVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETER 507
+ QL + + + E Q V+E L+ E ++++ ++
Sbjct: 2296 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340
Score = 30.8 bits (68), Expect = 3.7
Identities = 58/242 (23%), Positives = 95/242 (39%), Gaps = 25/242 (10%)
Query: 202 RLEEENSSLRELVEDLRAALQSSDARCLALQVG-LWKSQASTHEMGHGGPEAAVRELRQA 260
RL+ E R V LR L AR A ++ K+QA +G G R +A
Sbjct: 997 RLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG----VARLSAEA 1051
Query: 261 QGALAAAE-ARAGRLRRGQAEVRR-RAEEARQVVLRSLHRVRELEALAQQVPGLQRWVRR 318
+ LA E + A R + E+ + E+ R + L +++ + + + G + +R
Sbjct: 1052 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1111
Query: 319 LEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALD 378
E +L+ ++ + LP E S + A PT + R
Sbjct: 1112 HEEQLKEAQAVPATLP-----ELEATKASLKKLRAQAEAQQPTFDALRDE-----LRGAQ 1161
Query: 379 EVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLM 438
EV E+L Q E +VE ERW+E + +LA+ + R R +Q +L
Sbjct: 1162 EVGERL------QQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLR 1214
Query: 439 TY 440
Y
Sbjct: 1215 YY 1216
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 44.7 bits (104), Expect = 2e-04
Identities = 87/389 (22%), Positives = 144/389 (37%), Gaps = 59/389 (15%)
Query: 198 ERVARLEEE----NSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAA 253
E V R EE R + E+L+ QSS+A A QA E E
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA-----RQAEAAERSRLRIEEE 1453
Query: 254 VRELRQ-----------AQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVREL 302
+R +R A+G L A ARA + + + AE R+ V R R+
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513
Query: 303 E--------ALAQQVPGLQRWVRRLE---------------AELQRYRSEDSQLPTPQLA 339
E A A+ QR ++ LE AE++R R L T Q
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-- 1571
Query: 340 NPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEV 399
+ + + A + E + Q + + ++ +E + + + E + A +E E
Sbjct: 1572 --RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1629
Query: 400 EEERWQ---EEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGEL 456
E ERWQ E +A+ + + S + + Q E G + +
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR 1687
Query: 457 EACIAMLVEQLR-TQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEE 515
E L +Q + +G + L +E L+ + E+ E R Q++E E L+ L+
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR---QLLEEE---LARLQR 1741
Query: 516 KLVDVLQLLQRLRDLNISKRALGKILLST 544
+ Q Q L RA ++LL++
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Score = 40.4 bits (93), Expect = 0.005
Identities = 82/334 (24%), Positives = 122/334 (36%), Gaps = 33/334 (9%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
E +ARL+ E ++ + ++L A L A+ A L S+A E E + + L
Sbjct: 1734 EELARLQREAAAATQKRQELEAEL----AKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1789
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQRWVR 317
G A RLR E +R+ + A + R R LA+++ + R
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATR 1847
Query: 318 -RLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRA 376
+ EAE+ E +LA E + E A D E Q +S S
Sbjct: 1848 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKASDSEL 1906
Query: 377 LDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEK 436
E + L Q EEE+ + EK AA L L R +D K
Sbjct: 1907 --ERQKGLVEDTLRQRRQVEEEILALKASFEKA--AAGKAELELELGRIRSNAEDTLRSK 1962
Query: 437 LMTYFGHFGGANHAHTLGELEACIAMLV---EQLRTQGCGGRTLGT--SEEEAELQQKVE 491
ELEA + E+ R + R + +EEEA Q+K
Sbjct: 1963 EQA---------------ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 492 ENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQ 525
E RL+ ++ E R+R E++ LQL Q
Sbjct: 2008 LEEVERLKAKVEEARRLR-ERAEQESARQLQLAQ 2040
Score = 39.7 bits (91), Expect = 0.008
Identities = 80/321 (24%), Positives = 125/321 (38%), Gaps = 63/321 (19%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
ER+ RL E+ + R +E+ +AA +D Q L K+ S E G E +R+
Sbjct: 1864 ERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQ--LRKASDSELERQKGLVEDTLRQR 1920
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEAR---QVVLRSLHRVRELEALAQQVPGLQR 314
RQ + + A +A + G+AE+ R + LRS + ELEA Q
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQ------- 1972
Query: 315 WVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGS 374
R+L AE +R R E + LA E + +
Sbjct: 1973 --RQLAAEEERRRREAEERVQKSLAAEEEAARQRKA------------------------ 2006
Query: 375 RALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTA 434
AL+EV E+L VE +A E E+E ++ + A K L Q
Sbjct: 2007 -ALEEV-ERLKAKVE-EARRLRERAEQESARQLQLAQEAAQKRL-------------QAE 2050
Query: 435 EKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE 494
EK + TL + ++ +++QLR + R EEA +Q + E +
Sbjct: 2051 EKAHAFAVQQKEQELQQTLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2106
Query: 495 HLRLELQMVETERVRLSLLEE 515
R Q+ E ER++ S E+
Sbjct: 2107 SRR---QVEEAERLKQSAEEQ 2124
Score = 38.9 bits (89), Expect = 0.014
Identities = 92/442 (20%), Positives = 162/442 (36%), Gaps = 44/442 (9%)
Query: 127 EEARLALRAEPPELTFRQFHA-RLCGYFGTRAGPRLPRGALSEHIETQIRLRRPRRRRRP 185
EEAR+ E + + A RL +A R A +E + + RR +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153
Query: 186 PCAPGPDSGPDCERVARLEEENSSLRELVE------DLRAALQSSDARCLALQVGLWKSQ 239
A D E + +LR+ + LR L+ +D + L L + +
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213
Query: 240 ASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRV 299
A E A R+ Q + L + + L + +A + E R ++LR
Sbjct: 2214 AEATE--------AARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNT 2262
Query: 300 -RELEALAQQVPGLQRWVRRL-----EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDA 353
R L+ A+++ + RL EA R +E+ LA +K ++A
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2322
Query: 354 GTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQE-EKKTPA 412
+ + + +R L E EQ+ + + + + +E ER ++ E A
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 413 AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGC 472
K +A +S + R ++ A++ G H L E + +++ Q
Sbjct: 2383 ERLKLRVAEMSRAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2441
Query: 473 G------GRTLGTSEEEAE--------LQQKVEENEHLRLELQMVETERVRLSLLEEKLV 518
+ E E E LQ K EE + ++ E + ET+ ++ S L EK
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-- 2499
Query: 519 DVLQLLQRLRDLNISKRALGKI 540
LLQR R + K L ++
Sbjct: 2500 --DSLLQRERFIEQEKAKLEQL 2519
Score = 37.4 bits (85), Expect = 0.040
Identities = 83/404 (20%), Positives = 144/404 (35%), Gaps = 77/404 (19%)
Query: 196 DCERVARLEEENSSLRE------LVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGG 249
+ E +R++ E + RE +E+LR + ++ R +V + E
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 250 PEAAV---------------RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLR 294
EA + R L++ A+A A R + QAE R EEA + + R
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 295 SLHRVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ E L Q + + +AE ++ + E + + E + E +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 355 TRDPDPTPEGAWQ-------------SDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEE 401
EG Q +++ G + ++E+L R AA+ ++ E
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 402 ERWQEEKKTPAAEAKTLL---ARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEA 458
E E AE + LL AR +++ ++L G F L E A
Sbjct: 1754 E---AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF------RELAEEAA 1804
Query: 459 CIAMLVEQLRTQ------------------------GCGGRTLGTSEEEAELQQKVEENE 494
+ L E+ + Q G T +E E L++K ENE
Sbjct: 1805 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1864
Query: 495 HLRLELQMVETERVRLSLLEEKL----VDVLQLLQRLRDLNISK 534
LR ++ E E + LEE+ D+ + L +LR + S+
Sbjct: 1865 RLR---RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1905
Score = 33.9 bits (76), Expect = 0.44
Identities = 78/345 (22%), Positives = 133/345 (38%), Gaps = 51/345 (14%)
Query: 196 DCERVARLEEENSSLRELVED-----LRAALQSSDARCLA---------------LQVGL 235
+ ER+ EE LRE E L+ A +++ R A LQ L
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 236 WKSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRS 295
+ Q+ ++ G EAA R +A+ A AE A A+ RR+ EEA ++
Sbjct: 2070 QQEQSVLDQL-RGEAEAARRAAEEAEEARVQAEREA-------AQSRRQVEEAERL---K 2118
Query: 296 LHRVRELEALAQQVPGLQRWVRRLEAE-LQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ +A AQ ++ + E E +R ++E + L Q A+ E E
Sbjct: 2119 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Query: 355 TRDPDPTPEGA---WQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEE------RWQ 405
+ E Q + + + L + + Q ++ +AA +VEEE + +
Sbjct: 2179 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238
Query: 406 EEKKTPA---AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAM 462
E K A AE + L+ R R + AEK+ A A L + A A
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV------AEEAARL-SVAAQEAA 2291
Query: 463 LVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETER 507
+ QL + + + E Q V+E L+ E ++++ ++
Sbjct: 2292 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Score = 30.8 bits (68), Expect = 3.7
Identities = 58/242 (23%), Positives = 95/242 (39%), Gaps = 25/242 (10%)
Query: 202 RLEEENSSLRELVEDLRAALQSSDARCLALQVG-LWKSQASTHEMGHGGPEAAVRELRQA 260
RL+ E R V LR L AR A ++ K+QA +G G R +A
Sbjct: 993 RLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG----VARLSAEA 1047
Query: 261 QGALAAAE-ARAGRLRRGQAEVRR-RAEEARQVVLRSLHRVRELEALAQQVPGLQRWVRR 318
+ LA E + A R + E+ + E+ R + L +++ + + + G + +R
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107
Query: 319 LEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALD 378
E +L+ ++ + LP E S + A PT + R
Sbjct: 1108 HEEQLKEAQAVPATLP-----ELEATKASLKKLRAQAEAQQPTFDALRDE-----LRGAQ 1157
Query: 379 EVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLM 438
EV E+L Q E +VE ERW+E + +LA+ + R R +Q +L
Sbjct: 1158 EVGERL------QQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLR 1210
Query: 439 TY 440
Y
Sbjct: 1211 YY 1212
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 44.7 bits (104), Expect = 2e-04
Identities = 87/389 (22%), Positives = 144/389 (37%), Gaps = 59/389 (15%)
Query: 198 ERVARLEEE----NSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAA 253
E V R EE R + E+L+ QSS+A A QA E E
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA-----RQAEAAERSRLRIEEE 1421
Query: 254 VRELRQ-----------AQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVREL 302
+R +R A+G L A ARA + + + AE R+ V R R+
Sbjct: 1422 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481
Query: 303 E--------ALAQQVPGLQRWVRRLE---------------AELQRYRSEDSQLPTPQLA 339
E A A+ QR ++ LE AE++R R L T Q
Sbjct: 1482 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-- 1539
Query: 340 NPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEV 399
+ + + A + E + Q + + ++ +E + + + E + A +E E
Sbjct: 1540 --RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1597
Query: 400 EEERWQ---EEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGEL 456
E ERWQ E +A+ + + S + + Q E G + +
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR 1655
Query: 457 EACIAMLVEQLR-TQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEE 515
E L +Q + +G + L +E L+ + E+ E R Q++E E L+ L+
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR---QLLEEE---LARLQR 1709
Query: 516 KLVDVLQLLQRLRDLNISKRALGKILLST 544
+ Q Q L RA ++LL++
Sbjct: 1710 EAAAATQKRQELEAELAKVRAEMEVLLAS 1738
Score = 40.4 bits (93), Expect = 0.005
Identities = 82/334 (24%), Positives = 122/334 (36%), Gaps = 33/334 (9%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
E +ARL+ E ++ + ++L A L A+ A L S+A E E + + L
Sbjct: 1702 EELARLQREAAAATQKRQELEAEL----AKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1757
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQRWVR 317
G A RLR E +R+ + A + R R LA+++ + R
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATR 1815
Query: 318 -RLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRA 376
+ EAE+ E +LA E + E A D E Q +S S
Sbjct: 1816 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKASDSEL 1874
Query: 377 LDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEK 436
E + L Q EEE+ + EK AA L L R +D K
Sbjct: 1875 --ERQKGLVEDTLRQRRQVEEEILALKASFEKA--AAGKAELELELGRIRSNAEDTLRSK 1930
Query: 437 LMTYFGHFGGANHAHTLGELEACIAMLV---EQLRTQGCGGRTLGT--SEEEAELQQKVE 491
ELEA + E+ R + R + +EEEA Q+K
Sbjct: 1931 EQA---------------ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1975
Query: 492 ENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQ 525
E RL+ ++ E R+R E++ LQL Q
Sbjct: 1976 LEEVERLKAKVEEARRLR-ERAEQESARQLQLAQ 2008
Score = 39.7 bits (91), Expect = 0.008
Identities = 80/321 (24%), Positives = 125/321 (38%), Gaps = 63/321 (19%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
ER+ RL E+ + R +E+ +AA +D Q L K+ S E G E +R+
Sbjct: 1832 ERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQ--LRKASDSELERQKGLVEDTLRQR 1888
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEAR---QVVLRSLHRVRELEALAQQVPGLQR 314
RQ + + A +A + G+AE+ R + LRS + ELEA Q
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQ------- 1940
Query: 315 WVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGS 374
R+L AE +R R E + LA E + +
Sbjct: 1941 --RQLAAEEERRRREAEERVQKSLAAEEEAARQRKA------------------------ 1974
Query: 375 RALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTA 434
AL+EV E+L VE +A E E+E ++ + A K L Q
Sbjct: 1975 -ALEEV-ERLKAKVE-EARRLRERAEQESARQLQLAQEAAQKRL-------------QAE 2018
Query: 435 EKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE 494
EK + TL + ++ +++QLR + R EEA +Q + E +
Sbjct: 2019 EKAHAFAVQQKEQELQQTLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2074
Query: 495 HLRLELQMVETERVRLSLLEE 515
R Q+ E ER++ S E+
Sbjct: 2075 SRR---QVEEAERLKQSAEEQ 2092
Score = 38.9 bits (89), Expect = 0.014
Identities = 92/442 (20%), Positives = 162/442 (36%), Gaps = 44/442 (9%)
Query: 127 EEARLALRAEPPELTFRQFHA-RLCGYFGTRAGPRLPRGALSEHIETQIRLRRPRRRRRP 185
EEAR+ E + + A RL +A R A +E + + RR +
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2121
Query: 186 PCAPGPDSGPDCERVARLEEENSSLRELVE------DLRAALQSSDARCLALQVGLWKSQ 239
A D E + +LR+ + LR L+ +D + L L + +
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2181
Query: 240 ASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRV 299
A E A R+ Q + L + + L + +A + E R ++LR
Sbjct: 2182 AEATE--------AARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNT 2230
Query: 300 -RELEALAQQVPGLQRWVRRL-----EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDA 353
R L+ A+++ + RL EA R +E+ LA +K ++A
Sbjct: 2231 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2290
Query: 354 GTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQE-EKKTPA 412
+ + + +R L E EQ+ + + + + +E ER ++ E A
Sbjct: 2291 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2350
Query: 413 AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGC 472
K +A +S + R ++ A++ G H L E + +++ Q
Sbjct: 2351 ERLKLRVAEMSRAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2409
Query: 473 G------GRTLGTSEEEAE--------LQQKVEENEHLRLELQMVETERVRLSLLEEKLV 518
+ E E E LQ K EE + ++ E + ET+ ++ S L EK
Sbjct: 2410 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-- 2467
Query: 519 DVLQLLQRLRDLNISKRALGKI 540
LLQR R + K L ++
Sbjct: 2468 --DSLLQRERFIEQEKAKLEQL 2487
Score = 37.4 bits (85), Expect = 0.040
Identities = 83/404 (20%), Positives = 144/404 (35%), Gaps = 77/404 (19%)
Query: 196 DCERVARLEEENSSLRE------LVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGG 249
+ E +R++ E + RE +E+LR + ++ R +V + E
Sbjct: 1482 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1541
Query: 250 PEAAV---------------RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLR 294
EA + R L++ A+A A R + QAE R EEA + + R
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Query: 295 SLHRVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ E L Q + + +AE ++ + E + + E + E +
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661
Query: 355 TRDPDPTPEGAWQ-------------SDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEE 401
EG Q +++ G + ++E+L R AA+ ++ E
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 402 ERWQEEKKTPAAEAKTLL---ARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEA 458
E E AE + LL AR +++ ++L G F L E A
Sbjct: 1722 E---AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF------RELAEEAA 1772
Query: 459 CIAMLVEQLRTQ------------------------GCGGRTLGTSEEEAELQQKVEENE 494
+ L E+ + Q G T +E E L++K ENE
Sbjct: 1773 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1832
Query: 495 HLRLELQMVETERVRLSLLEEKL----VDVLQLLQRLRDLNISK 534
LR ++ E E + LEE+ D+ + L +LR + S+
Sbjct: 1833 RLR---RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1873
Score = 33.9 bits (76), Expect = 0.44
Identities = 78/345 (22%), Positives = 133/345 (38%), Gaps = 51/345 (14%)
Query: 196 DCERVARLEEENSSLRELVED-----LRAALQSSDARCLA---------------LQVGL 235
+ ER+ EE LRE E L+ A +++ R A LQ L
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 236 WKSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRS 295
+ Q+ ++ G EAA R +A+ A AE A A+ RR+ EEA ++
Sbjct: 2038 QQEQSVLDQL-RGEAEAARRAAEEAEEARVQAEREA-------AQSRRQVEEAERL---K 2086
Query: 296 LHRVRELEALAQQVPGLQRWVRRLEAE-LQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ +A AQ ++ + E E +R ++E + L Q A+ E E
Sbjct: 2087 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Query: 355 TRDPDPTPEGA---WQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEE------RWQ 405
+ E Q + + + L + + Q ++ +AA +VEEE + +
Sbjct: 2147 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206
Query: 406 EEKKTPA---AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAM 462
E K A AE + L+ R R + AEK+ A A L + A A
Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV------AEEAARL-SVAAQEAA 2259
Query: 463 LVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETER 507
+ QL + + + E Q V+E L+ E ++++ ++
Sbjct: 2260 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2304
Score = 30.8 bits (68), Expect = 3.7
Identities = 58/242 (23%), Positives = 95/242 (39%), Gaps = 25/242 (10%)
Query: 202 RLEEENSSLRELVEDLRAALQSSDARCLALQVG-LWKSQASTHEMGHGGPEAAVRELRQA 260
RL+ E R V LR L AR A ++ K+QA +G G R +A
Sbjct: 961 RLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG----VARLSAEA 1015
Query: 261 QGALAAAE-ARAGRLRRGQAEVRR-RAEEARQVVLRSLHRVRELEALAQQVPGLQRWVRR 318
+ LA E + A R + E+ + E+ R + L +++ + + + G + +R
Sbjct: 1016 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1075
Query: 319 LEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALD 378
E +L+ ++ + LP E S + A PT + R
Sbjct: 1076 HEEQLKEAQAVPATLP-----ELEATKASLKKLRAQAEAQQPTFDALRDE-----LRGAQ 1125
Query: 379 EVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLM 438
EV E+L Q E +VE ERW+E + +LA+ + R R +Q +L
Sbjct: 1126 EVGERL------QQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLR 1178
Query: 439 TY 440
Y
Sbjct: 1179 YY 1180
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 44.7 bits (104), Expect = 2e-04
Identities = 87/389 (22%), Positives = 144/389 (37%), Gaps = 59/389 (15%)
Query: 198 ERVARLEEE----NSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAA 253
E V R EE R + E+L+ QSS+A A QA E E
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA-----RQAEAAERSRLRIEEE 1590
Query: 254 VRELRQ-----------AQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVREL 302
+R +R A+G L A ARA + + + AE R+ V R R+
Sbjct: 1591 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650
Query: 303 E--------ALAQQVPGLQRWVRRLE---------------AELQRYRSEDSQLPTPQLA 339
E A A+ QR ++ LE AE++R R L T Q
Sbjct: 1651 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-- 1708
Query: 340 NPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEV 399
+ + + A + E + Q + + ++ +E + + + E + A +E E
Sbjct: 1709 --RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766
Query: 400 EEERWQ---EEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGEL 456
E ERWQ E +A+ + + S + + Q E G + +
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR 1824
Query: 457 EACIAMLVEQLR-TQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEE 515
E L +Q + +G + L +E L+ + E+ E R Q++E E L+ L+
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR---QLLEEE---LARLQR 1878
Query: 516 KLVDVLQLLQRLRDLNISKRALGKILLST 544
+ Q Q L RA ++LL++
Sbjct: 1879 EAAAATQKRQELEAELAKVRAEMEVLLAS 1907
Score = 40.4 bits (93), Expect = 0.005
Identities = 82/334 (24%), Positives = 122/334 (36%), Gaps = 33/334 (9%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
E +ARL+ E ++ + ++L A L A+ A L S+A E E + + L
Sbjct: 1871 EELARLQREAAAATQKRQELEAEL----AKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1926
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQRWVR 317
G A RLR E +R+ + A + R R LA+++ + R
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATR 1984
Query: 318 -RLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRA 376
+ EAE+ E +LA E + E A D E Q +S S
Sbjct: 1985 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKASDSEL 2043
Query: 377 LDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEK 436
E + L Q EEE+ + EK AA L L R +D K
Sbjct: 2044 --ERQKGLVEDTLRQRRQVEEEILALKASFEKA--AAGKAELELELGRIRSNAEDTLRSK 2099
Query: 437 LMTYFGHFGGANHAHTLGELEACIAMLV---EQLRTQGCGGRTLGT--SEEEAELQQKVE 491
ELEA + E+ R + R + +EEEA Q+K
Sbjct: 2100 EQA---------------ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2144
Query: 492 ENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQ 525
E RL+ ++ E R+R E++ LQL Q
Sbjct: 2145 LEEVERLKAKVEEARRLR-ERAEQESARQLQLAQ 2177
Score = 39.7 bits (91), Expect = 0.008
Identities = 80/321 (24%), Positives = 125/321 (38%), Gaps = 63/321 (19%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
ER+ RL E+ + R +E+ +AA +D Q L K+ S E G E +R+
Sbjct: 2001 ERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQ--LRKASDSELERQKGLVEDTLRQR 2057
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEAR---QVVLRSLHRVRELEALAQQVPGLQR 314
RQ + + A +A + G+AE+ R + LRS + ELEA Q
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQ------- 2109
Query: 315 WVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGS 374
R+L AE +R R E + LA E + +
Sbjct: 2110 --RQLAAEEERRRREAEERVQKSLAAEEEAARQRKA------------------------ 2143
Query: 375 RALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTA 434
AL+EV E+L VE +A E E+E ++ + A K L Q
Sbjct: 2144 -ALEEV-ERLKAKVE-EARRLRERAEQESARQLQLAQEAAQKRL-------------QAE 2187
Query: 435 EKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE 494
EK + TL + ++ +++QLR + R EEA +Q + E +
Sbjct: 2188 EKAHAFAVQQKEQELQQTLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2243
Query: 495 HLRLELQMVETERVRLSLLEE 515
R Q+ E ER++ S E+
Sbjct: 2244 SRR---QVEEAERLKQSAEEQ 2261
Score = 38.9 bits (89), Expect = 0.014
Identities = 92/442 (20%), Positives = 162/442 (36%), Gaps = 44/442 (9%)
Query: 127 EEARLALRAEPPELTFRQFHA-RLCGYFGTRAGPRLPRGALSEHIETQIRLRRPRRRRRP 185
EEAR+ E + + A RL +A R A +E + + RR +
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2290
Query: 186 PCAPGPDSGPDCERVARLEEENSSLRELVE------DLRAALQSSDARCLALQVGLWKSQ 239
A D E + +LR+ + LR L+ +D + L L + +
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2350
Query: 240 ASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRV 299
A E A R+ Q + L + + L + +A + E R ++LR
Sbjct: 2351 AEATE--------AARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNT 2399
Query: 300 -RELEALAQQVPGLQRWVRRL-----EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDA 353
R L+ A+++ + RL EA R +E+ LA +K ++A
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2459
Query: 354 GTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQE-EKKTPA 412
+ + + +R L E EQ+ + + + + +E ER ++ E A
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519
Query: 413 AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGC 472
K +A +S + R ++ A++ G H L E + +++ Q
Sbjct: 2520 ERLKLRVAEMSRAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2578
Query: 473 G------GRTLGTSEEEAE--------LQQKVEENEHLRLELQMVETERVRLSLLEEKLV 518
+ E E E LQ K EE + ++ E + ET+ ++ S L EK
Sbjct: 2579 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-- 2636
Query: 519 DVLQLLQRLRDLNISKRALGKI 540
LLQR R + K L ++
Sbjct: 2637 --DSLLQRERFIEQEKAKLEQL 2656
Score = 37.4 bits (85), Expect = 0.040
Identities = 83/404 (20%), Positives = 144/404 (35%), Gaps = 77/404 (19%)
Query: 196 DCERVARLEEENSSLRE------LVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGG 249
+ E +R++ E + RE +E+LR + ++ R +V + E
Sbjct: 1651 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1710
Query: 250 PEAAV---------------RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLR 294
EA + R L++ A+A A R + QAE R EEA + + R
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Query: 295 SLHRVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ E L Q + + +AE ++ + E + + E + E +
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830
Query: 355 TRDPDPTPEGAWQ-------------SDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEE 401
EG Q +++ G + ++E+L R AA+ ++ E
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 402 ERWQEEKKTPAAEAKTLL---ARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEA 458
E E AE + LL AR +++ ++L G F L E A
Sbjct: 1891 E---AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF------RELAEEAA 1941
Query: 459 CIAMLVEQLRTQ------------------------GCGGRTLGTSEEEAELQQKVEENE 494
+ L E+ + Q G T +E E L++K ENE
Sbjct: 1942 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 2001
Query: 495 HLRLELQMVETERVRLSLLEEKL----VDVLQLLQRLRDLNISK 534
LR ++ E E + LEE+ D+ + L +LR + S+
Sbjct: 2002 RLR---RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 2042
Score = 33.9 bits (76), Expect = 0.44
Identities = 78/345 (22%), Positives = 133/345 (38%), Gaps = 51/345 (14%)
Query: 196 DCERVARLEEENSSLRELVED-----LRAALQSSDARCLA---------------LQVGL 235
+ ER+ EE LRE E L+ A +++ R A LQ L
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 236 WKSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRS 295
+ Q+ ++ G EAA R +A+ A AE A A+ RR+ EEA ++
Sbjct: 2207 QQEQSVLDQL-RGEAEAARRAAEEAEEARVQAEREA-------AQSRRQVEEAERL---K 2255
Query: 296 LHRVRELEALAQQVPGLQRWVRRLEAE-LQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ +A AQ ++ + E E +R ++E + L Q A+ E E
Sbjct: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Query: 355 TRDPDPTPEGA---WQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEE------RWQ 405
+ E Q + + + L + + Q ++ +AA +VEEE + +
Sbjct: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375
Query: 406 EEKKTPA---AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAM 462
E K A AE + L+ R R + AEK+ A A L + A A
Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV------AEEAARL-SVAAQEAA 2428
Query: 463 LVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETER 507
+ QL + + + E Q V+E L+ E ++++ ++
Sbjct: 2429 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473
Score = 30.8 bits (68), Expect = 3.7
Identities = 58/242 (23%), Positives = 95/242 (39%), Gaps = 25/242 (10%)
Query: 202 RLEEENSSLRELVEDLRAALQSSDARCLALQVG-LWKSQASTHEMGHGGPEAAVRELRQA 260
RL+ E R V LR L AR A ++ K+QA +G G R +A
Sbjct: 1130 RLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG----VARLSAEA 1184
Query: 261 QGALAAAE-ARAGRLRRGQAEVRR-RAEEARQVVLRSLHRVRELEALAQQVPGLQRWVRR 318
+ LA E + A R + E+ + E+ R + L +++ + + + G + +R
Sbjct: 1185 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1244
Query: 319 LEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALD 378
E +L+ ++ + LP E S + A PT + R
Sbjct: 1245 HEEQLKEAQAVPATLP-----ELEATKASLKKLRAQAEAQQPTFDALRDE-----LRGAQ 1294
Query: 379 EVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLM 438
EV E+L Q E +VE ERW+E + +LA+ + R R +Q +L
Sbjct: 1295 EVGERL------QQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLR 1347
Query: 439 TY 440
Y
Sbjct: 1348 YY 1349
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 44.7 bits (104), Expect = 2e-04
Identities = 87/389 (22%), Positives = 144/389 (37%), Gaps = 59/389 (15%)
Query: 198 ERVARLEEE----NSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAA 253
E V R EE R + E+L+ QSS+A A QA E E
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA-----RQAEAAERSRLRIEEE 1431
Query: 254 VRELRQ-----------AQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVREL 302
+R +R A+G L A ARA + + + AE R+ V R R+
Sbjct: 1432 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491
Query: 303 E--------ALAQQVPGLQRWVRRLE---------------AELQRYRSEDSQLPTPQLA 339
E A A+ QR ++ LE AE++R R L T Q
Sbjct: 1492 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-- 1549
Query: 340 NPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEV 399
+ + + A + E + Q + + ++ +E + + + E + A +E E
Sbjct: 1550 --RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607
Query: 400 EEERWQ---EEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGEL 456
E ERWQ E +A+ + + S + + Q E G + +
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAERE--ARRRGKAEEQAVRQR 1665
Query: 457 EACIAMLVEQLR-TQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETERVRLSLLEE 515
E L +Q + +G + L +E L+ + E+ E R Q++E E L+ L+
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR---QLLEEE---LARLQR 1719
Query: 516 KLVDVLQLLQRLRDLNISKRALGKILLST 544
+ Q Q L RA ++LL++
Sbjct: 1720 EAAAATQKRQELEAELAKVRAEMEVLLAS 1748
Score = 40.4 bits (93), Expect = 0.005
Identities = 82/334 (24%), Positives = 122/334 (36%), Gaps = 33/334 (9%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
E +ARL+ E ++ + ++L A L A+ A L S+A E E + + L
Sbjct: 1712 EELARLQREAAAATQKRQELEAEL----AKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1767
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRVRELEALAQQVPGLQRWVR 317
G A RLR E +R+ + A + R R LA+++ + R
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ--RAEAERVLAEKLAAIGEATR 1825
Query: 318 -RLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRA 376
+ EAE+ E +LA E + E A D E Q +S S
Sbjct: 1826 LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKASDSEL 1884
Query: 377 LDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEK 436
E + L Q EEE+ + EK AA L L R +D K
Sbjct: 1885 --ERQKGLVEDTLRQRRQVEEEILALKASFEKA--AAGKAELELELGRIRSNAEDTLRSK 1940
Query: 437 LMTYFGHFGGANHAHTLGELEACIAMLV---EQLRTQGCGGRTLGT--SEEEAELQQKVE 491
ELEA + E+ R + R + +EEEA Q+K
Sbjct: 1941 EQA---------------ELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1985
Query: 492 ENEHLRLELQMVETERVRLSLLEEKLVDVLQLLQ 525
E RL+ ++ E R+R E++ LQL Q
Sbjct: 1986 LEEVERLKAKVEEARRLR-ERAEQESARQLQLAQ 2018
Score = 39.7 bits (91), Expect = 0.008
Identities = 80/321 (24%), Positives = 125/321 (38%), Gaps = 63/321 (19%)
Query: 198 ERVARLEEENSSLRELVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGGPEAAVREL 257
ER+ RL E+ + R +E+ +AA +D Q L K+ S E G E +R+
Sbjct: 1842 ERLRRLAEDEAFQRRRLEE-QAAQHKADIEERLAQ--LRKASDSELERQKGLVEDTLRQR 1898
Query: 258 RQAQGALAAAEARAGRLRRGQAEVRRRAEEAR---QVVLRSLHRVRELEALAQQVPGLQR 314
RQ + + A +A + G+AE+ R + LRS + ELEA Q
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQA-ELEAARQ------- 1950
Query: 315 WVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGS 374
R+L AE +R R E + LA E + +
Sbjct: 1951 --RQLAAEEERRRREAEERVQKSLAAEEEAARQRKA------------------------ 1984
Query: 375 RALDEVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTA 434
AL+EV E+L VE +A E E+E ++ + A K L Q
Sbjct: 1985 -ALEEV-ERLKAKVE-EARRLRERAEQESARQLQLAQEAAQKRL-------------QAE 2028
Query: 435 EKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGCGGRTLGTSEEEAELQQKVEENE 494
EK + TL + ++ +++QLR + R EEA +Q + E +
Sbjct: 2029 EKAHAFAVQQKEQELQQTLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQ 2084
Query: 495 HLRLELQMVETERVRLSLLEE 515
R Q+ E ER++ S E+
Sbjct: 2085 SRR---QVEEAERLKQSAEEQ 2102
Score = 38.9 bits (89), Expect = 0.014
Identities = 92/442 (20%), Positives = 162/442 (36%), Gaps = 44/442 (9%)
Query: 127 EEARLALRAEPPELTFRQFHA-RLCGYFGTRAGPRLPRGALSEHIETQIRLRRPRRRRRP 185
EEAR+ E + + A RL +A R A +E + + RR +
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2131
Query: 186 PCAPGPDSGPDCERVARLEEENSSLRELVE------DLRAALQSSDARCLALQVGLWKSQ 239
A D E + +LR+ + LR L+ +D + L L + +
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2191
Query: 240 ASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRSLHRV 299
A E A R+ Q + L + + L + +A + E R ++LR
Sbjct: 2192 AEATE--------AARQRSQVEEELFSVRVQMEELSKLKARIEA---ENRALILRDKDNT 2240
Query: 300 -RELEALAQQVPGLQRWVRRL-----EAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDA 353
R L+ A+++ + RL EA R +E+ LA +K ++A
Sbjct: 2241 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA 2300
Query: 354 GTRDPDPTPEGAWQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEERWQE-EKKTPA 412
+ + + +R L E EQ+ + + + + +E ER ++ E A
Sbjct: 2301 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360
Query: 413 AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAMLVEQLRTQGC 472
K +A +S + R ++ A++ G H L E + +++ Q
Sbjct: 2361 ERLKLRVAEMSRAQARAEED-AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419
Query: 473 G------GRTLGTSEEEAE--------LQQKVEENEHLRLELQMVETERVRLSLLEEKLV 518
+ E E E LQ K EE + ++ E + ET+ ++ S L EK
Sbjct: 2420 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-- 2477
Query: 519 DVLQLLQRLRDLNISKRALGKI 540
LLQR R + K L ++
Sbjct: 2478 --DSLLQRERFIEQEKAKLEQL 2497
Score = 37.4 bits (85), Expect = 0.040
Identities = 83/404 (20%), Positives = 144/404 (35%), Gaps = 77/404 (19%)
Query: 196 DCERVARLEEENSSLRE------LVEDLRAALQSSDARCLALQVGLWKSQASTHEMGHGG 249
+ E +R++ E + RE +E+LR + ++ R +V + E
Sbjct: 1492 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1551
Query: 250 PEAAV---------------RELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLR 294
EA + R L++ A+A A R + QAE R EEA + + R
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
Query: 295 SLHRVRELEALAQQVPGLQRWVRRLEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ E L Q + + +AE ++ + E + + E + E +
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
Query: 355 TRDPDPTPEGAWQ-------------SDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEE 401
EG Q +++ G + ++E+L R AA+ ++ E
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 402 ERWQEEKKTPAAEAKTLL---ARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEA 458
E E AE + LL AR +++ ++L G F L E A
Sbjct: 1732 E---AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF------RELAEEAA 1782
Query: 459 CIAMLVEQLRTQ------------------------GCGGRTLGTSEEEAELQQKVEENE 494
+ L E+ + Q G T +E E L++K ENE
Sbjct: 1783 RLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENE 1842
Query: 495 HLRLELQMVETERVRLSLLEEKL----VDVLQLLQRLRDLNISK 534
LR ++ E E + LEE+ D+ + L +LR + S+
Sbjct: 1843 RLR---RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE 1883
Score = 33.9 bits (76), Expect = 0.44
Identities = 78/345 (22%), Positives = 133/345 (38%), Gaps = 51/345 (14%)
Query: 196 DCERVARLEEENSSLRELVED-----LRAALQSSDARCLA---------------LQVGL 235
+ ER+ EE LRE E L+ A +++ R A LQ L
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047
Query: 236 WKSQASTHEMGHGGPEAAVRELRQAQGALAAAEARAGRLRRGQAEVRRRAEEARQVVLRS 295
+ Q+ ++ G EAA R +A+ A AE A A+ RR+ EEA ++
Sbjct: 2048 QQEQSVLDQL-RGEAEAARRAAEEAEEARVQAEREA-------AQSRRQVEEAERL---K 2096
Query: 296 LHRVRELEALAQQVPGLQRWVRRLEAE-LQRYRSEDSQLPTPQLANPEPGDKSNEPEDAG 354
+ +A AQ ++ + E E +R ++E + L Q A+ E E
Sbjct: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Query: 355 TRDPDPTPEGA---WQSDSSSGSRALDEVDEQLFRSVEGQAASDEEEVEEE------RWQ 405
+ E Q + + + L + + Q ++ +AA +VEEE + +
Sbjct: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216
Query: 406 EEKKTPA---AEAKTLLARLSSCRGRCDDQTAEKLMTYFGHFGGANHAHTLGELEACIAM 462
E K A AE + L+ R R + AEK+ A A L + A A
Sbjct: 2217 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQV------AEEAARL-SVAAQEAA 2269
Query: 463 LVEQLRTQGCGGRTLGTSEEEAELQQKVEENEHLRLELQMVETER 507
+ QL + + + E Q V+E L+ E ++++ ++
Sbjct: 2270 RLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314
Score = 30.8 bits (68), Expect = 3.7
Identities = 58/242 (23%), Positives = 95/242 (39%), Gaps = 25/242 (10%)
Query: 202 RLEEENSSLRELVEDLRAALQSSDARCLALQVG-LWKSQASTHEMGHGGPEAAVRELRQA 260
RL+ E R V LR L AR A ++ K+QA +G G R +A
Sbjct: 971 RLQLEACETRT-VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG----VARLSAEA 1025
Query: 261 QGALAAAE-ARAGRLRRGQAEVRR-RAEEARQVVLRSLHRVRELEALAQQVPGLQRWVRR 318
+ LA E + A R + E+ + E+ R + L +++ + + + G + +R
Sbjct: 1026 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1085
Query: 319 LEAELQRYRSEDSQLPTPQLANPEPGDKSNEPEDAGTRDPDPTPEGAWQSDSSSGSRALD 378
E +L+ ++ + LP E S + A PT + R
Sbjct: 1086 HEEQLKEAQAVPATLP-----ELEATKASLKKLRAQAEAQQPTFDALRDE-----LRGAQ 1135
Query: 379 EVDEQLFRSVEGQAASDEEEVEEERWQEEKKTPAAEAKTLLARLSSCRGRCDDQTAEKLM 438
EV E+L Q E +VE ERW+E + +LA+ + R R +Q +L
Sbjct: 1136 EVGERL------QQRHGERDVEVERWRERVAQLLERWQAVLAQ-TDVRQRELEQLGRQLR 1188
Query: 439 TY 440
Y
Sbjct: 1189 YY 1190
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,469,395
Number of Sequences: 37866
Number of extensions: 1311616
Number of successful extensions: 10497
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 382
Number of HSP's that attempted gapping in prelim test: 9088
Number of HSP's gapped (non-prelim): 1452
length of query: 598
length of database: 18,247,518
effective HSP length: 108
effective length of query: 490
effective length of database: 14,157,990
effective search space: 6937415100
effective search space used: 6937415100
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.