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Search of human proteins with 22748931
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22748931 F-box and leucine-rich repeat protein 14 [Homo
sapiens]
(418 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens] 832 0.0
gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens] 168 7e-42
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 141 1e-33
gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens] 135 9e-32
gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens] 120 2e-27
gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1 ... 115 6e-26
gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2 ... 112 6e-25
gi|254039600 F-box and leucine-rich repeat protein 17 [Homo sapi... 111 1e-24
gi|190194416 F-box and leucine-rich repeat protein 15 [Homo sapi... 78 2e-14
gi|164663798 antagonist of mitotic exit network 1 homolog [Homo ... 66 5e-11
gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens] 66 7e-11
gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens] 66 7e-11
gi|157168349 F-box and leucine-rich repeat protein 19 [Homo sapi... 64 2e-10
gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [H... 64 3e-10
gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens] 63 4e-10
gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [H... 63 6e-10
gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [... 55 2e-07
gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [... 55 2e-07
gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens] 54 3e-07
gi|16306584 F-box and leucine-rich repeat protein 3 [Homo sapiens] 52 1e-06
gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens] 51 2e-06
gi|122937219 F-box protein 41 [Homo sapiens] 50 5e-06
gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo ... 45 1e-04
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 43 5e-04
gi|40788015 caspase recruitment domain protein 12 [Homo sapiens] 43 6e-04
gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo ... 41 0.002
gi|194018550 c-Maf-inducing protein isoform C-mip [Homo sapiens] 41 0.002
gi|29789255 c-Maf-inducing protein isoform Tc-mip [Homo sapiens] 41 0.002
gi|22547146 F-box and leucine-rich repeat protein 8 [Homo sapiens] 41 0.002
gi|8922303 ATP5S-like [Homo sapiens] 40 0.004
>gi|22748931 F-box and leucine-rich repeat protein 14 [Homo sapiens]
Length = 418
Score = 832 bits (2150), Expect = 0.0
Identities = 418/418 (100%), Positives = 418/418 (100%)
Query: 1 METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPS 60
METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPS
Sbjct: 1 METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPS 60
Query: 61 LFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLR 120
LFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLR
Sbjct: 61 LFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLR 120
Query: 121 ALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCR 180
ALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCR
Sbjct: 121 ALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCR 180
Query: 181 HLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGG 240
HLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGG
Sbjct: 181 HLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGG 240
Query: 241 ISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYI 300
ISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYI
Sbjct: 241 ISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYI 300
Query: 301 AQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTG 360
AQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTG
Sbjct: 301 AQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTG 360
Query: 361 IDLYGCTRITKRGLERITQLPCLKVLNLGLWQMTDSEKEARGDFSPLFTVRTRGSSRR 418
IDLYGCTRITKRGLERITQLPCLKVLNLGLWQMTDSEKEARGDFSPLFTVRTRGSSRR
Sbjct: 361 IDLYGCTRITKRGLERITQLPCLKVLNLGLWQMTDSEKEARGDFSPLFTVRTRGSSRR 418
>gi|16306582 F-box and leucine-rich repeat protein 2 [Homo sapiens]
Length = 423
Score = 168 bits (426), Expect = 7e-42
Identities = 126/388 (32%), Positives = 190/388 (48%), Gaps = 22/388 (5%)
Query: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70
ELL IF +LD+ R AQ+ AW A S W+ ++ + ++ R
Sbjct: 18 ELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRVVENISKRCG 77
Query: 71 RRVQILSLR-------RSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALN 123
++ LSLR SL Q NIE LNL+GC +TD+ ++ + L+ L+
Sbjct: 78 GFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTC-YSLSRFCSKLKHLD 136
Query: 124 LSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLS 183
L+ C IT+SSL I++ + LE L L C IT G+ + G + LK+L LR C L
Sbjct: 137 LTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLRGCTQLE 196
Query: 184 DVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISD 243
D + H+ C L L LQ C ++TD + I RG L+ L LS C ++D
Sbjct: 197 DEALKHIQNY-------CHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTD 249
Query: 244 AGLLHLS-HMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQ 302
A L L + L+ L C +++D G LA L +D+ C + D +L ++
Sbjct: 250 ASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSI 309
Query: 303 GLDGLKSLSLCSCH-ISDDGINRMVRQMHG---LRTLNIGQCVRITDKGLELIAEHLSQL 358
L++LSL C I+DDGI + G LR L + C+ ITD LE + E+ L
Sbjct: 310 HCPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHL-ENCRGL 368
Query: 359 TGIDLYGCTRITKRGLERI-TQLPCLKV 385
++LY C ++T+ G++R+ QLP +KV
Sbjct: 369 ERLELYDCQQVTRAGIKRMRAQLPHVKV 396
Score = 139 bits (351), Expect = 4e-33
Identities = 89/278 (32%), Positives = 141/278 (50%), Gaps = 13/278 (4%)
Query: 117 GSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNL 176
G LR L+L C + DSSL AQ + +E L L GC+ IT++ ++ +LK L+L
Sbjct: 78 GFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDL 137
Query: 177 RSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLS 236
SC +++ + + +EGC LE L L C ++T ++ + RG GL+ L L
Sbjct: 138 TSCVSITNSSL-------KGISEGCRNLEYLNLSWCDQITKDGIEALVRGCRGLKALLLR 190
Query: 237 FCGGISDAGLLHL-SHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQ 295
C + D L H+ ++ L SLNL+SC I+D G++ + G RL L +S C + D
Sbjct: 191 GCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCLSGCSNLTDA 250
Query: 296 SLAYIAQGLDGLKSLSLCSC-HISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEH 354
SL + L+ L C H++D G + R H L +++ +C+ ITD L ++ H
Sbjct: 251 SLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIH 310
Query: 355 LSQLTGIDLYGCTRITKRGLERITQLPC----LKVLNL 388
+L + L C IT G+ ++ C L+VL L
Sbjct: 311 CPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLEL 348
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
Length = 436
Score = 141 bits (356), Expect = 1e-33
Identities = 122/400 (30%), Positives = 182/400 (45%), Gaps = 46/400 (11%)
Query: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70
ELL IF +LDV R AQV AW A S W+ ++ LF +
Sbjct: 31 ELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRID-----------LFDFQRDIEG 79
Query: 71 RRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQI 130
R V+ +S R + L+L GC + DN L F Q ++ LNL+ C +
Sbjct: 80 RVVENISKRCG--------GFLRKLSLRGCLGVGDNAL-RTFAQNCRNIEVLNLNGCTKT 130
Query: 131 TDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHL 190
TD++ ++++ L L+L C++ITN L ++ G L+ LN+ C ++ GI L
Sbjct: 131 TDATCTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQAL 190
Query: 191 ----AGMTRSAAEGCLGLEQ---------------LTLQDCQKLTDLSLKHISRGLTGLR 231
G+ +GC LE L LQ C ++TD L I RG L+
Sbjct: 191 VRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQ 250
Query: 232 LLNLSFCGGISDAGLLHL-SHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCD 290
L S C I+DA L L + LR L + C ++D G LA L +D+ C
Sbjct: 251 SLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECV 310
Query: 291 KVGDQSLAYIAQGLDGLKSLSLCSCH-ISDDGINRM---VRQMHGLRTLNIGQCVRITDK 346
++ D +L ++ L+ LSL C I+DDGI + L + + C ITD
Sbjct: 311 QITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDA 370
Query: 347 GLELIAEHLSQLTGIDLYGCTRITKRGLERI-TQLPCLKV 385
LE + + L I+LY C +IT+ G++R+ T LP +KV
Sbjct: 371 SLEHL-KSCHSLERIELYDCQQITRAGIKRLRTHLPNIKV 409
>gi|6912466 F-box and leucine-rich repeat protein 7 [Homo sapiens]
Length = 491
Score = 135 bits (339), Expect = 9e-32
Identities = 103/369 (27%), Positives = 176/369 (47%), Gaps = 40/369 (10%)
Query: 13 LAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEA-----------KLHLRRA---N 58
+ IF +L R A+VC W + A+ +WR + K+ RR
Sbjct: 122 MVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDT 181
Query: 59 PS---LFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQE 115
P+ + ++ G RR+ R L + Q + L +SGCYN+++ + V
Sbjct: 182 PNVCLMLETVTVSGCRRLT----DRGLYTIAQCCPELRRLEVSGCYNISNEAVFDV-VSL 236
Query: 116 IGSLRALNLSLCKQITDSSLGRIAQY----LKGLEV----LELGGCSNITNTGLLLIAWG 167
+L L++S C ++T SL R A L G ++ L++ C + + GL IA
Sbjct: 237 CPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAH 296
Query: 168 LQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGL 227
+L L LR C L+D G+ +L C +++L++ DC+ ++D L+ I++
Sbjct: 297 CTQLTHLYLRRCVRLTDEGLRYLVIY-------CASIKELSVSDCRFVSDFGLREIAKLE 349
Query: 228 TGLRLLNLSFCGGISDAGLLHLS-HMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDV 286
+ LR L+++ CG ++D G+ +++ + LR LN R C+ I+D G+ +LA +L LD+
Sbjct: 350 SRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDI 409
Query: 287 SFCDKVGDQSLAYIAQGLDGLKSLSLCSCH-ISDDGINRMVRQMHGLRTLNIGQCVRITD 345
C V D L +A LK LSL SC I+ G+ + L+TLN+ C ++
Sbjct: 410 GKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDC-EVSV 468
Query: 346 KGLELIAEH 354
+ L + H
Sbjct: 469 EALRFVKRH 477
Score = 92.0 bits (227), Expect = 9e-19
Identities = 68/247 (27%), Positives = 119/247 (48%), Gaps = 26/247 (10%)
Query: 145 LEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGL 204
LE + + GC +T+ GL IA L+ L + C ++S+ + + + C L
Sbjct: 188 LETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSL-------CPNL 240
Query: 205 EQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCD 264
E L + C K+T +SL T + LS LH + S+R L++ C
Sbjct: 241 EHLDVSGCSKVTCISL-------TREASIKLS---------PLHGKQI-SIRYLDMTDCF 283
Query: 265 NISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCH-ISDDGIN 323
+ D G+ +A +L+ L + C ++ D+ L Y+ +K LS+ C +SD G+
Sbjct: 284 VLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLR 343
Query: 324 RMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCL 383
+ + LR L+I C R+TD G+ +A++ S+L ++ GC IT G+E + + C
Sbjct: 344 EIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAK-NCT 402
Query: 384 KVLNLGL 390
K+ +L +
Sbjct: 403 KLKSLDI 409
>gi|24025682 F-box and leucine-rich repeat protein 16 [Homo sapiens]
Length = 479
Score = 120 bits (302), Expect = 2e-27
Identities = 110/371 (29%), Positives = 161/371 (43%), Gaps = 79/371 (21%)
Query: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSL------FPS 64
++L +F Y +K AQVC AWR Y W G+ LH + L F +
Sbjct: 100 KILNGLFWYFSACEKCVLAQVCKAWRRVLYQPKFWAGLTPVLHAKELYNVLPGGEKEFVN 159
Query: 65 LQ---ARGI------------------------RRVQILSLRRS------LSYVIQGMAN 91
LQ ARG + V+ +SL+RS L +++ M
Sbjct: 160 LQGFAARGFEGFCLVGVSDLDICEFIDNYALSKKGVKAMSLKRSTITDAGLEVMLEQMQG 219
Query: 92 IESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGL------ 145
+ L LSGC + T+ GL + I S L++S C + D ++ I+Q L L
Sbjct: 220 VVRLELSGCNDFTEAGLWSSLSARITS---LSVSDCINVADDAIAAISQLLPNLAELSLQ 276
Query: 146 --------------------EVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDV 185
L L C ITN G++ + L L +L+L C ++D
Sbjct: 277 AYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNLTALSLSGCSKVTDD 336
Query: 186 GIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAG 245
G+ AE L L L C ++TD++L++++ L L L L C I+D G
Sbjct: 337 GV-------ELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRCVRITDTG 389
Query: 246 LLHLSHMGSLRSLNLRSCDNISDTGIMH-LAMGSLRLSGLDVSFCDKVGDQSLAYIAQGL 304
L +LS M SLRSL LR C + D G+ H LA+GSLRL L + C + L+ + Q L
Sbjct: 390 LSYLSTMSSLRSLYLRWCCQVQDFGLKHLLALGSLRL--LSPAGCPLLTTTGLSGLVQ-L 446
Query: 305 DGLKSLSLCSC 315
L+ L L +C
Sbjct: 447 QELEELELTNC 457
Score = 76.3 bits (186), Expect = 5e-14
Identities = 58/188 (30%), Positives = 97/188 (51%), Gaps = 14/188 (7%)
Query: 215 LTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHL 274
+TD L+ + + G+ L LS C ++AGL S + SL++ C N++D I +
Sbjct: 205 ITDAGLEVMLEQMQGVVRLELSGCNDFTEAGLWS-SLSARITSLSVSDCINVADDAIAAI 263
Query: 275 AMGSLRLSGLDVSFCDKVGDQSLAYI-AQGLDGLKSLSLCSC-HISDDGINRMVRQMHGL 332
+ L+ L + V D +LAY A+ +L L SC I++ G+ +V + L
Sbjct: 264 SQLLPNLAELSLQ-AYHVTDTALAYFTARQGHSTHTLRLLSCWEITNHGVVNVVHSLPNL 322
Query: 333 RTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLE-------RITQL---PC 382
L++ C ++TD G+EL+AE+L +L +DL C RIT LE R+ +L C
Sbjct: 323 TALSLSGCSKVTDDGVELVAENLRKLRSLDLSWCPRITDMALEYVACDLHRLEELVLDRC 382
Query: 383 LKVLNLGL 390
+++ + GL
Sbjct: 383 VRITDTGL 390
>gi|161333852 F-box and leucine-rich repeat protein 13 isoform 1
[Homo sapiens]
Length = 735
Score = 115 bits (289), Expect = 6e-26
Identities = 87/265 (32%), Positives = 135/265 (50%), Gaps = 15/265 (5%)
Query: 118 SLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWG--LQRLKSLN 175
+L + ++ CK ITDSSL ++ LK L VL L C I + GL G R++ LN
Sbjct: 427 NLSHIYMADCKGITDSSLRSLSP-LKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELN 485
Query: 176 LRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNL 235
L +C LSD + L+ E C L L+L++C+ LT + +I + L+++
Sbjct: 486 LSNCVRLSDASVMKLS-------ERCPNLNYLSLRNCEHLTAQGIGYI---VNIFSLVSI 535
Query: 236 SFCG-GISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGD 294
G IS+ GL LS L+ L++ C I+D GI SL L LDVS+C ++ D
Sbjct: 536 DLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSD 595
Query: 295 QSLAYIAQGLDGLKSLSLCSC-HISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAE 353
+ +A L SLS+ C I+D + + + H L L+I CV +TD+ LE +
Sbjct: 596 MIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQI 655
Query: 354 HLSQLTGIDLYGCTRITKRGLERIT 378
QL + + CT I+K+ +R++
Sbjct: 656 GCKQLRILKMQYCTNISKKAAQRMS 680
Score = 108 bits (269), Expect = 1e-23
Identities = 117/488 (23%), Positives = 189/488 (38%), Gaps = 120/488 (24%)
Query: 1 METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPS 60
++ IS L + IF YL ++D QV AW S+W ++
Sbjct: 151 LKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDK 210
Query: 61 LFPSLQARGIRRVQILSLR---------RSLSYVIQGMANIESLNLSGCYNLTDNGLGHA 111
S R V L+ R RS+S+ N++ LN+S C TD + H
Sbjct: 211 YIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHC----RNLQELNVSDCPTFTDESMRHI 266
Query: 112 ------------------------FVQEIGSLRALNLSLCKQITDSSLGRIAQYLK---- 143
+ +L+ L+L+ C++ TD L QYL
Sbjct: 267 SEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGL----QYLNLGNG 322
Query: 144 --GLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSD----------------- 184
L L+L GC+ I+ G IA + L + L+D
Sbjct: 323 CHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLV 382
Query: 185 -VGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISD 243
G H++ T A C L ++ + +++TD S K I + L + ++ C GI+D
Sbjct: 383 FTGAPHISDCTFRALSACK-LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITD 441
Query: 244 AGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMG--SLRLSGLDVSFCDKVGDQSLAYIA 301
+ L LS + L LNL +C I D G+ G S+R+ L++S C ++ D S+ ++
Sbjct: 442 SSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLS 501
Query: 302 QGLDGLKSLSLCSCH-------------------------ISDDGINRMVRQMHGLRTLN 336
+ L LSL +C IS++G+N + R L+ L+
Sbjct: 502 ERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKK-LKELS 560
Query: 337 IGQCVRITDKGLE------LIAEHLS--------------------QLTGIDLYGCTRIT 370
+ +C RITD G++ LI EHL LT + + GC +IT
Sbjct: 561 VSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKIT 620
Query: 371 KRGLERIT 378
+E ++
Sbjct: 621 DSAMEMLS 628
Score = 61.6 bits (148), Expect = 1e-09
Identities = 36/115 (31%), Positives = 63/115 (54%), Gaps = 3/115 (2%)
Query: 281 LSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQC 340
L L+VS C D+S+ +I++G G+ L+L + I++ + + R H L+ L++ C
Sbjct: 247 LQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYC 306
Query: 341 VRITDKGLEL--IAEHLSQLTGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQM 393
R TDKGL+ + +L +DL GCT+I+ +G I C +++L + M
Sbjct: 307 RRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIAN-SCTGIMHLTINDM 360
Score = 55.8 bits (133), Expect = 7e-08
Identities = 36/140 (25%), Positives = 68/140 (48%), Gaps = 8/140 (5%)
Query: 85 VIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKG 144
V+ ++ L++S CY +TD+G+ AF + L L++S C Q++D + +A Y
Sbjct: 549 VLSRHKKLKELSVSECYRITDDGI-QAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCIN 607
Query: 145 LEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGL 204
L L + GC IT++ + +++ L L++ C L+D + GC L
Sbjct: 608 LTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTD-------QILEDLQIGCKQL 660
Query: 205 EQLTLQDCQKLTDLSLKHIS 224
L +Q C ++ + + +S
Sbjct: 661 RILKMQYCTNISKKAAQRMS 680
>gi|161333854 F-box and leucine-rich repeat protein 13 isoform 2
[Homo sapiens]
Length = 690
Score = 112 bits (280), Expect = 6e-25
Identities = 118/491 (24%), Positives = 198/491 (40%), Gaps = 102/491 (20%)
Query: 1 METHISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPS 60
++ IS L + IF YL ++D QV AW S+W ++
Sbjct: 151 LKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDK 210
Query: 61 LFPSLQARGIRRVQILSLR---------RSLSYVIQGMANIESLNLSGCYNLTDNGLGHA 111
S R V L+ R RS+S+ N++ LN+S C TD + H
Sbjct: 211 YIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHC----RNLQELNVSDCPTFTDESMRHI 266
Query: 112 ------------------------FVQEIGSLRALNLSLCKQITDSSLGRIAQYLK---- 143
+ +L+ L+L+ C++ TD L QYL
Sbjct: 267 SEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGL----QYLNLGNG 322
Query: 144 --GLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSD----------------- 184
L L+L GC+ I+ G IA + L + L+D
Sbjct: 323 CHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLV 382
Query: 185 -VGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISD 243
G H++ T A C L ++ + +++TD S K I + L + ++ C GI+D
Sbjct: 383 FTGAPHISDCTFRALSACK-LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITD 441
Query: 244 AGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMG--SLRLSGLDVSFCDKVGDQSLAYIA 301
+ L LS + L LNL +C I D G+ G S+R+ L++S C ++ D S+ ++
Sbjct: 442 SSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLS 501
Query: 302 QGLDGLKSLSLCSCH-------------------------ISDDGINRMVRQMHGLRTLN 336
+ L LSL +C IS++G+N + R L+ L+
Sbjct: 502 ERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKK-LKELS 560
Query: 337 IGQCVRITDKGLELIAEHLSQLTG-------IDLYGCTRITKRGLERITQLPCLKVLNLG 389
+ +C RITD G+++ + L+ +D+ GC +T + LE + Q+ C ++ L
Sbjct: 561 VSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDL-QIGCKQLRILK 619
Query: 390 LWQMTDSEKEA 400
+ T+ K+A
Sbjct: 620 MQYCTNISKKA 630
Score = 60.1 bits (144), Expect = 4e-09
Identities = 54/196 (27%), Positives = 86/196 (43%), Gaps = 30/196 (15%)
Query: 80 RSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRA--LNLSLCKQITDSSLGR 137
RSLS + Q + LNL+ C + D GL F+ S+R LNLS C +++D+S+ +
Sbjct: 445 RSLSPLKQ----LTVLNLANCVRIGDMGLKQ-FLDGPASMRIRELNLSNCVRLSDASVMK 499
Query: 138 IAQYLKGLEVLELGGCSNITNTGLLLIA-----------------WGL------QRLKSL 174
+++ L L L C ++T G+ I GL ++LK L
Sbjct: 500 LSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKEL 559
Query: 175 NLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLN 234
++ C ++D GI + C L L + C LTD L+ + G LR+L
Sbjct: 560 SVSECYRITDDGIQITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILK 619
Query: 235 LSFCGGISDAGLLHLS 250
+ +C IS +S
Sbjct: 620 MQYCTNISKKAAQRMS 635
>gi|254039600 F-box and leucine-rich repeat protein 17 [Homo
sapiens]
Length = 303
Score = 111 bits (277), Expect = 1e-24
Identities = 74/277 (26%), Positives = 142/277 (51%), Gaps = 9/277 (3%)
Query: 103 LTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLL 162
++DNG+ + G LR CKQ++D+S+ +A + L+ + +G +T+ GL
Sbjct: 1 MSDNGVCVLAFKCPGLLR-YTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLK 59
Query: 163 LIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKH 222
+ + LK ++ C +SD G+ +A +GCL L+++ +Q+ + +TD S+K
Sbjct: 60 QLGSKCRELKDIHFGQCYKISDEGMIVIA-------KGCLKLQRIYMQENKLVTDQSVKA 112
Query: 223 ISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLS 282
+ L+ + C ++ G++HL+ + +L SL+LR + + +M + LS
Sbjct: 113 FAEHCPELQYVGFMGCS-VTSKGVIHLTKLRNLSSLDLRHITELDNETVMEIVKRCKNLS 171
Query: 283 GLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVR 342
L++ + D+ + IA+ LK L L SC I+D + + R + T+++G C
Sbjct: 172 SLNLCLNWIINDRCVEVIAKEGQNLKELYLVSCKITDYALIAIGRYSMTIETVDVGWCKE 231
Query: 343 ITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQ 379
ITD+G LIA+ L + L C ++ + +E++ Q
Sbjct: 232 ITDQGATLIAQSSKSLRYLGLMRCDKVNEVTVEQLVQ 268
>gi|190194416 F-box and leucine-rich repeat protein 15 [Homo
sapiens]
Length = 300
Score = 77.8 bits (190), Expect = 2e-14
Identities = 56/201 (27%), Positives = 103/201 (51%), Gaps = 11/201 (5%)
Query: 129 QITDSSLGRIAQYLKGLEVLELGGCSN-ITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGI 187
QI ++L R+ + +GL+ L L C +++ L+ + +L+S+ L C LS +
Sbjct: 73 QIPRAALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARNPQLRSVALGGCGQLSRRAL 132
Query: 188 GHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLL 247
G LA EGC L++L+L C + L+L+ ++ L L+L+ C + D ++
Sbjct: 133 GALA-------EGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIV 185
Query: 248 HLSHM--GSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLD 305
+L+ LRSL+L N+ D + LA L LD++ C +VG + +A+
Sbjct: 186 YLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRTLAEYCP 245
Query: 306 GLKSLSLCSC-HISDDGINRM 325
L+SL + C H+++ ++R+
Sbjct: 246 VLRSLRVRHCHHVAESSLSRL 266
Score = 68.6 bits (166), Expect = 1e-11
Identities = 59/224 (26%), Positives = 103/224 (45%), Gaps = 14/224 (6%)
Query: 164 IAWGLQRLKSLNLRSCRHLSDVGIGH------LAGMTRSAAEGCLGLEQLTLQDCQK-LT 216
++ + L L+L R +G LA + R A GL++L L C + L+
Sbjct: 47 VSRAFRSLVQLHLAGLRRFDAAQVGPQIPRAALARLLRDAE----GLQELALAPCHEWLS 102
Query: 217 DLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSH-MGSLRSLNLRSCDNISDTGIMHLA 275
D L + LR + L CG +S L L+ L+ L+L CD + + LA
Sbjct: 103 DEDLVPVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLA 162
Query: 276 MGSLRLSGLDVSFCDKVGDQSLAYIAQGLD-GLKSLSLC-SCHISDDGINRMVRQMHGLR 333
L LD++ C ++ D+++ Y+AQ GL+SLSL + ++ D + + R L
Sbjct: 163 DRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPELH 222
Query: 334 TLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERI 377
L++ C+R+ G+ +AE+ L + + C + + L R+
Sbjct: 223 HLDLTGCLRVGSDGVRTLAEYCPVLRSLRVRHCHHVAESSLSRL 266
Score = 65.1 bits (157), Expect = 1e-10
Identities = 60/229 (26%), Positives = 110/229 (48%), Gaps = 19/229 (8%)
Query: 65 LQARGIRRVQILSL-----RRSLSYVIQGMANIESLNLSGCYN-LTDNGLGHAFVQEIGS 118
L G+RR + R +L+ +++ ++ L L+ C+ L+D L +
Sbjct: 57 LHLAGLRRFDAAQVGPQIPRAALARLLRDAEGLQELALAPCHEWLSDEDLVPVLARN-PQ 115
Query: 119 LRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRS 178
LR++ L C Q++ +LG +A+ L+ L L C + L +A L+ L+L +
Sbjct: 116 LRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPALEELDLTA 175
Query: 179 CRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFC 238
CR L D I +LA R A GL L+L + D +++ ++R L L+L+ C
Sbjct: 176 CRQLKDEAIVYLA-QRRGA-----GLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGC 229
Query: 239 GGISDAGLLHLS-HMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDV 286
+ G+ L+ + LRSL +R C +++++ ++ LR G+D+
Sbjct: 230 LRVGSDGVRTLAEYCPVLRSLRVRHCHHVAES-----SLSRLRKRGVDI 273
Score = 63.5 bits (153), Expect = 3e-10
Identities = 58/205 (28%), Positives = 97/205 (47%), Gaps = 15/205 (7%)
Query: 189 HLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGG-ISDAGLL 247
HLAG+ R A Q ++ +L + R GL+ L L+ C +SD L+
Sbjct: 58 HLAGLRRFDAA----------QVGPQIPRAALARLLRDAEGLQELALAPCHEWLSDEDLV 107
Query: 248 H-LSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDG 306
L+ LRS+ L C +S + LA G RL L ++ CD V +L +A
Sbjct: 108 PVLARNPQLRSVALGGCGQLSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLADRCPA 167
Query: 307 LKSLSLCSCH-ISDDGINRMV-RQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLY 364
L+ L L +C + D+ I + R+ GLR+L++ + D ++ +A + +L +DL
Sbjct: 168 LEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLT 227
Query: 365 GCTRITKRGLERITQ-LPCLKVLNL 388
GC R+ G+ + + P L+ L +
Sbjct: 228 GCLRVGSDGVRTLAEYCPVLRSLRV 252
>gi|164663798 antagonist of mitotic exit network 1 homolog [Homo
sapiens]
Length = 258
Score = 66.2 bits (160), Expect = 5e-11
Identities = 48/184 (26%), Positives = 91/184 (49%), Gaps = 9/184 (4%)
Query: 204 LEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGG----ISDAGLLHLSHMGS-LRSL 258
++ L L+ C ++D +L H+S L+ LNL+ G ++ G+ ++ S L
Sbjct: 63 VQTLDLRSCD-ISDAALLHLSN-CRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHEA 120
Query: 259 NLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHIS 318
+L+ C N++D G++ LA+ L +D+ C + D SL + + L+ + + +S
Sbjct: 121 SLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQVS 180
Query: 319 DDGINRMVRQ--MHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLER 376
D G+ +V L +++G CV +TD +E + + Q+ + +GC IT E
Sbjct: 181 DSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITDHSREV 240
Query: 377 ITQL 380
+ QL
Sbjct: 241 LEQL 244
Score = 51.6 bits (122), Expect = 1e-06
Identities = 49/214 (22%), Positives = 98/214 (45%), Gaps = 17/214 (7%)
Query: 124 LSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLS 183
+S+ QITDS++ I ++ L+L C +I++ LL ++ ++LK LNL + +
Sbjct: 44 MSMQGQITDSNISEILH--PEVQTLDLRSC-DISDAALLHLS-NCRKLKKLNLNASK--- 96
Query: 184 DVGIGHLAGMT----RSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCG 239
G+ +T ++ A C L + +L+ C LTD + ++ L++++L C
Sbjct: 97 ----GNRVSVTSEGIKAVASSCSYLHEASLKRCCNLTDEGVVALALNCQLLKIIDLGGCL 152
Query: 240 GISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMG--SLRLSGLDVSFCDKVGDQSL 297
I+D L L S +SD+G++ L G + +L + + C + D ++
Sbjct: 153 SITDVSLHALGKNCPFLQCVDFSATQVSDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAV 212
Query: 298 AYIAQGLDGLKSLSLCSCHISDDGINRMVRQMHG 331
+ ++ L C + D ++ Q+ G
Sbjct: 213 EAVLTYCPQIRILLFHGCPLITDHSREVLEQLVG 246
Score = 45.1 bits (105), Expect = 1e-04
Identities = 41/176 (23%), Positives = 77/176 (43%), Gaps = 27/176 (15%)
Query: 92 IESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCK----QITDSSLGRIAQYLKGLEV 147
+++L+L C +++D L H + L+ LNL+ K +T + +A L
Sbjct: 63 VQTLDLRSC-DISDAALLH--LSNCRKLKKLNLNASKGNRVSVTSEGIKAVASSCSYLHE 119
Query: 148 LELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLA-----------GMTRS 196
L C N+T+ G++ +A Q LK ++L C ++DV + L T+
Sbjct: 120 ASLKRCCNLTDEGVVALALNCQLLKIIDLGGCLSITDVSLHALGKNCPFLQCVDFSATQV 179
Query: 197 AAEGCLG---------LEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISD 243
+ G + LE++ + C LTD +++ + +R+L C I+D
Sbjct: 180 SDSGVIALVSGPCAKKLEEIHMGHCVNLTDGAVEAVLTYCPQIRILLFHGCPLITD 235
>gi|51873034 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 65.9 bits (159), Expect = 7e-11
Identities = 42/129 (32%), Positives = 69/129 (53%), Gaps = 8/129 (6%)
Query: 118 SLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLR 177
+L+ L+L+ C ++TD+SL ++ Q+L+ L L L +T+ GL+ +A G L+ L L
Sbjct: 76 ALQELDLTACSKLTDASLAKVLQFLQ-LRQLSLSLLPELTDNGLVAVARGCPSLEHLALS 134
Query: 178 SCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSF 237
C LSD G AA L+ L L C +L + +L I + LR+L+++
Sbjct: 135 HCSRLSDKG-------WAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVAT 187
Query: 238 CGGISDAGL 246
C GI+ A +
Sbjct: 188 CPGINMAAV 196
Score = 58.9 bits (141), Expect = 8e-09
Identities = 43/149 (28%), Positives = 69/149 (46%), Gaps = 9/149 (6%)
Query: 92 IESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELG 151
++ L+L+ C LTD L A V + LR L+LSL ++TD+ L +A+ LE L L
Sbjct: 77 LQELDLTACSKLTDASL--AKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALS 134
Query: 152 GCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQD 211
CS +++ G A RL+ LNL SC L + + + + C L L +
Sbjct: 135 HCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLD-------AIGQACRQLRVLDVAT 187
Query: 212 CQKLTDLSLKHISRGLTGLRLLNLSFCGG 240
C + +++ L + + F GG
Sbjct: 188 CPGINMAAVRRFQAQLPQVSCVQSRFVGG 216
Score = 56.2 bits (134), Expect = 5e-08
Identities = 49/192 (25%), Positives = 83/192 (43%), Gaps = 20/192 (10%)
Query: 170 RLKSLNLRSCRHL-SDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLT 228
+L SL+L C L S + H A T+ A G LTL+ Q+L
Sbjct: 34 QLASLSLAHCSSLKSRPELEHQASGTKDACPEPQGPSLLTLRALQEL------------- 80
Query: 229 GLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSF 288
+L+ C ++DA L + LR L+L ++D G++ +A G L L +S
Sbjct: 81 -----DLTACSKLTDASLAKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 289 CDKVGDQSLAYIAQGLDGLKSLSLCSC-HISDDGINRMVRQMHGLRTLNIGQCVRITDKG 347
C ++ D+ A A L+ L+L SC + + ++ + + LR L++ C I
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAA 195
Query: 348 LELIAEHLSQLT 359
+ L Q++
Sbjct: 196 VRRFQAQLPQVS 207
Score = 54.3 bits (129), Expect = 2e-07
Identities = 52/201 (25%), Positives = 87/201 (43%), Gaps = 19/201 (9%)
Query: 189 HLAGMTRSAAEGCLG-----LEQLTLQDCQKLTDL-SLKHISRGLTGLRLLNLSFCGGIS 242
H G + A GC+ L L+L C L L+H + G C
Sbjct: 15 HGRGRELAQALGCMHGAPSQLASLSLAHCSSLKSRPELEHQASGTKDA-------CPEPQ 67
Query: 243 DAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQ 302
LL L +L+ L+L +C ++D + + + L+L L +S ++ D L +A+
Sbjct: 68 GPSLLTLR---ALQELDLTACSKLTDASLAKV-LQFLQLRQLSLSLLPELTDNGLVAVAR 123
Query: 303 GLDGLKSLSLCSC-HISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGI 361
G L+ L+L C +SD G + L+ LN+ C ++ ++ L+ I + QL +
Sbjct: 124 GCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVL 183
Query: 362 DLYGCTRITKRGLERI-TQLP 381
D+ C I + R QLP
Sbjct: 184 DVATCPGINMAAVRRFQAQLP 204
Score = 47.4 bits (111), Expect = 2e-05
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 13/105 (12%)
Query: 52 LHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHA 111
L LR+ + SL P L G L V +G ++E L LS C L+D G A
Sbjct: 100 LQLRQLSLSLLPELTDNG------------LVAVARGCPSLEHLALSHCSRLSDKGWAQA 147
Query: 112 FVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNI 156
L+ LNLS C Q+ + +L I Q + L VL++ C I
Sbjct: 148 -ASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGI 191
>gi|16306591 F-box and leucine-rich repeat protein 9 [Homo sapiens]
Length = 223
Score = 65.9 bits (159), Expect = 7e-11
Identities = 42/129 (32%), Positives = 69/129 (53%), Gaps = 8/129 (6%)
Query: 118 SLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLR 177
+L+ L+L+ C ++TD+SL ++ Q+L+ L L L +T+ GL+ +A G L+ L L
Sbjct: 76 ALQELDLTACSKLTDASLAKVLQFLQ-LRQLSLSLLPELTDNGLVAVARGCPSLEHLALS 134
Query: 178 SCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSF 237
C LSD G AA L+ L L C +L + +L I + LR+L+++
Sbjct: 135 HCSRLSDKG-------WAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVAT 187
Query: 238 CGGISDAGL 246
C GI+ A +
Sbjct: 188 CPGINMAAV 196
Score = 58.9 bits (141), Expect = 8e-09
Identities = 43/149 (28%), Positives = 69/149 (46%), Gaps = 9/149 (6%)
Query: 92 IESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELG 151
++ L+L+ C LTD L A V + LR L+LSL ++TD+ L +A+ LE L L
Sbjct: 77 LQELDLTACSKLTDASL--AKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALS 134
Query: 152 GCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQD 211
CS +++ G A RL+ LNL SC L + + + + C L L +
Sbjct: 135 HCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLD-------AIGQACRQLRVLDVAT 187
Query: 212 CQKLTDLSLKHISRGLTGLRLLNLSFCGG 240
C + +++ L + + F GG
Sbjct: 188 CPGINMAAVRRFQAQLPQVSCVQSRFVGG 216
Score = 56.2 bits (134), Expect = 5e-08
Identities = 49/192 (25%), Positives = 83/192 (43%), Gaps = 20/192 (10%)
Query: 170 RLKSLNLRSCRHL-SDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLT 228
+L SL+L C L S + H A T+ A G LTL+ Q+L
Sbjct: 34 QLASLSLAHCSSLKSRPELEHQASGTKDACPEPQGPSLLTLRALQEL------------- 80
Query: 229 GLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSF 288
+L+ C ++DA L + LR L+L ++D G++ +A G L L +S
Sbjct: 81 -----DLTACSKLTDASLAKVLQFLQLRQLSLSLLPELTDNGLVAVARGCPSLEHLALSH 135
Query: 289 CDKVGDQSLAYIAQGLDGLKSLSLCSC-HISDDGINRMVRQMHGLRTLNIGQCVRITDKG 347
C ++ D+ A A L+ L+L SC + + ++ + + LR L++ C I
Sbjct: 136 CSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGINMAA 195
Query: 348 LELIAEHLSQLT 359
+ L Q++
Sbjct: 196 VRRFQAQLPQVS 207
Score = 54.3 bits (129), Expect = 2e-07
Identities = 52/201 (25%), Positives = 87/201 (43%), Gaps = 19/201 (9%)
Query: 189 HLAGMTRSAAEGCLG-----LEQLTLQDCQKLTDL-SLKHISRGLTGLRLLNLSFCGGIS 242
H G + A GC+ L L+L C L L+H + G C
Sbjct: 15 HGRGRELAQALGCMHGAPSQLASLSLAHCSSLKSRPELEHQASGTKDA-------CPEPQ 67
Query: 243 DAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQ 302
LL L +L+ L+L +C ++D + + + L+L L +S ++ D L +A+
Sbjct: 68 GPSLLTLR---ALQELDLTACSKLTDASLAKV-LQFLQLRQLSLSLLPELTDNGLVAVAR 123
Query: 303 GLDGLKSLSLCSC-HISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGI 361
G L+ L+L C +SD G + L+ LN+ C ++ ++ L+ I + QL +
Sbjct: 124 GCPSLEHLALSHCSRLSDKGWAQAASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVL 183
Query: 362 DLYGCTRITKRGLERI-TQLP 381
D+ C I + R QLP
Sbjct: 184 DVATCPGINMAAVRRFQAQLP 204
Score = 47.4 bits (111), Expect = 2e-05
Identities = 35/105 (33%), Positives = 48/105 (45%), Gaps = 13/105 (12%)
Query: 52 LHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHA 111
L LR+ + SL P L G L V +G ++E L LS C L+D G A
Sbjct: 100 LQLRQLSLSLLPELTDNG------------LVAVARGCPSLEHLALSHCSRLSDKGWAQA 147
Query: 112 FVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNI 156
L+ LNLS C Q+ + +L I Q + L VL++ C I
Sbjct: 148 -ASSWPRLQHLNLSSCSQLIEQTLDAIGQACRQLRVLDVATCPGI 191
>gi|157168349 F-box and leucine-rich repeat protein 19 [Homo
sapiens]
Length = 694
Score = 64.3 bits (155), Expect = 2e-10
Identities = 67/258 (25%), Positives = 107/258 (41%), Gaps = 32/258 (12%)
Query: 16 IFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRVQI 75
+F +L R+ +VC W Y K +W ++ L R P L R+ +
Sbjct: 432 VFQHLGPRELCICMRVCRTWSRWCYDKRLW----PRMDLSRRKSLTPPMLSGVVRRQPRA 487
Query: 76 LSL------RRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQ 129
L L ++ L +++ + ++ L LSGC L+ + LG A + +LR L+L +
Sbjct: 488 LDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSA---PLPALRLLDLRWIED 544
Query: 130 ITDSSLGRI--------------AQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLN 175
+ DS L + L+G+ L L G +T+ L L+ +L +L+
Sbjct: 545 VKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGL-ELTDASLRLLLRHAPQLSALD 603
Query: 176 LRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNL 235
L C H+ D + L T E L L L C +LTD L + R LR L+L
Sbjct: 604 LSHCAHVGDPSVHLLTAPTSPLRE---TLVHLNLAGCHRLTDHCLP-LFRRCPRLRRLDL 659
Query: 236 SFCGGISDAGLLHLSHMG 253
C +S L+ G
Sbjct: 660 RSCRQLSPEACARLAAAG 677
Score = 47.4 bits (111), Expect = 2e-05
Identities = 46/189 (24%), Positives = 81/189 (42%), Gaps = 20/189 (10%)
Query: 231 RLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCD 290
R L+LS+ G + L+ + L+ L L C +S + + + +LRL LD+ + +
Sbjct: 486 RALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRL--LDLRWIE 543
Query: 291 KVGDQSLAYI-------------AQG-LDGLKSLSLCSCHISDDGINRMVRQMHGLRTLN 336
V D L + ++G L G+ L L ++D + ++R L L+
Sbjct: 544 DVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALD 603
Query: 337 IGQCVRITDKGLELIAEHLSQL----TGIDLYGCTRITKRGLERITQLPCLKVLNLGLWQ 392
+ C + D + L+ S L ++L GC R+T L + P L+ L+L +
Sbjct: 604 LSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCR 663
Query: 393 MTDSEKEAR 401
E AR
Sbjct: 664 QLSPEACAR 672
>gi|61742136 F-box and leucine-rich repeat protein 6 isoform 2 [Homo
sapiens]
Length = 533
Score = 63.5 bits (153), Expect = 3e-10
Identities = 102/400 (25%), Positives = 163/400 (40%), Gaps = 68/400 (17%)
Query: 11 ELLAMIFGYLDVRDK-----GRAAQVCTAWRDAAYHKSVWR---------------GVEA 50
E+L IFG L D GRAA+VC W++AA ++W GV+A
Sbjct: 118 EILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSPLVGRPAKGGVKA 177
Query: 51 KLHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGH 110
+ L + L P+ ++ ++R+ ++ + L V + + L LSGC+ +T + L
Sbjct: 178 EKKLLASLEWLMPNRFSQ-LQRLTLIHWKSQL--VGECCPRLTFLKLSGCHGVTADALVM 234
Query: 111 ------------------------AFVQEIGS-LRALNLSLCKQITDSSLGRIAQYLKGL 145
+F++E GS +R L L+ Q T + L
Sbjct: 235 LAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLGSCCPQL 294
Query: 146 EVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLE 205
+VLE+ N + L L LQ+ L+ R L+ + + G + G LE
Sbjct: 295 QVLEVSTGINRNSIPLQLPVEALQK-GCPQLQVLRLLNLMWLPKPPGRGVAPGPGFPSLE 353
Query: 206 QLTL--QDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGL----------LHLSHMG 253
+L L C +++ L + G LRLL+L C I+ AGL LHL G
Sbjct: 354 ELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQDLPCRELEQLHLGLYG 413
Query: 254 SLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDG----LKS 309
+ L L + T + L LSG F +K +Q+LA G L S
Sbjct: 414 TSDRLTLAKEGSPFLTQKWCHTLRELDLSG--QGFSEKDLEQALAAFLSTPGGSHPALCS 471
Query: 310 LSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLE 349
L+L ++ ++ ++ GL LN+ C R +GL+
Sbjct: 472 LNLRGTRVTPSTVSSVISSCPGLLYLNLESC-RCLPRGLK 510
Score = 32.3 bits (72), Expect = 0.82
Identities = 25/72 (34%), Positives = 38/72 (52%), Gaps = 6/72 (8%)
Query: 340 CVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPC--LKVLNLGLWQMTDSE 397
C ++++ L + L +DL GC RIT GL+ LPC L+ L+LGL+ +D
Sbjct: 362 CNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQ---DLPCRELEQLHLGLYGTSDRL 418
Query: 398 KEARGDFSPLFT 409
A+ + SP T
Sbjct: 419 TLAK-EGSPFLT 429
>gi|16306588 F-box and leucine-rich repeat protein 4 [Homo sapiens]
Length = 621
Score = 63.2 bits (152), Expect = 4e-10
Identities = 57/221 (25%), Positives = 106/221 (47%), Gaps = 15/221 (6%)
Query: 82 LSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRIAQY 141
L + + N+++LNLS C L H + ++ SL+ L L K + ++L I +
Sbjct: 393 LEVISEMCPNLQALNLSSCDKLPPQAFNH--IAKLCSLKRLVLYRTK-VEQTALLSILNF 449
Query: 142 LKGLEVLELGGCSNITNTGLL--LIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAE 199
L+ L LG C I + ++ +I ++L++L+L C+++++ GI L A
Sbjct: 450 CSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAEL-------AS 502
Query: 200 GCLGLEQLTLQDCQKLTDLS--LKHISRGLTGLRLLNLSFCGGISDAGLLHLS-HMGSLR 256
GC LE+L L C L + ++ L L+ L L+ + D + L+ + L+
Sbjct: 503 GCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQ 562
Query: 257 SLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSL 297
L++ +S + L LS LDVSFC ++ ++++
Sbjct: 563 QLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAV 603
Score = 60.8 bits (146), Expect = 2e-09
Identities = 72/264 (27%), Positives = 122/264 (46%), Gaps = 21/264 (7%)
Query: 122 LNLSLCKQITDSSLGRIAQYLK--GLEVLELG-GCSNITN-TGLLLIAWGLQRLKSLNLR 177
LNLS S+ +++LK G E++ L CS+ N T L +I+ L++LNL
Sbjct: 350 LNLSWTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLS 409
Query: 178 SCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSF 237
SC L H+A + L++L L K+ +L I + L+ L+L
Sbjct: 410 SCDKLPPQAFNHIAKLC--------SLKRLVLYRT-KVEQTALLSILNFCSELQHLSLGS 460
Query: 238 CGGISDAGLLHLSHMGS----LRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVG 293
C I D ++ S +G+ LR+L+L C NI++ GI LA G L LD+ +C +
Sbjct: 461 CVMIEDYDVI-ASMIGAKCKKLRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQ 519
Query: 294 DQSLAY--IAQGLDGLKSLSL-CSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLEL 350
+ + +A L L+ L L + + D I+ + L+ L+I ++ L
Sbjct: 520 SSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRK 579
Query: 351 IAEHLSQLTGIDLYGCTRITKRGL 374
+ E L+ +D+ C++I R +
Sbjct: 580 LLESCKDLSLLDVSFCSQIDNRAV 603
Score = 60.1 bits (144), Expect = 4e-09
Identities = 47/173 (27%), Positives = 84/173 (48%), Gaps = 10/173 (5%)
Query: 81 SLSYVIQGMANIESLNLSGCYNLTDNGLGHAFV-QEIGSLRALNLSLCKQITDSSLGRIA 139
+L ++ + ++ L+L C + D + + + + LR L+L CK IT++ + +A
Sbjct: 442 ALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKKLRTLDLWRCKNITENGIAELA 501
Query: 140 QYLKGLEVLELGGCSNI-TNTGLLL-IAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSA 197
LE L+LG C + ++TG +A L L+ L L + R + D I LA
Sbjct: 502 SGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFLTANRSVCDTDIDELAC----- 556
Query: 198 AEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLS 250
C L+QL + + ++ SL+ + L LL++SFC I + +L L+
Sbjct: 557 --NCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNRAVLELN 607
>gi|16306576 F-box and leucine-rich repeat protein 6 isoform 1 [Homo
sapiens]
Length = 539
Score = 62.8 bits (151), Expect = 6e-10
Identities = 101/404 (25%), Positives = 165/404 (40%), Gaps = 70/404 (17%)
Query: 11 ELLAMIFGYLDVRDK-----GRAAQVCTAWRDAAYHKSVWR---------------GVEA 50
E+L IFG L D GRAA+VC W++AA ++W GV+A
Sbjct: 118 EILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSPLVGRPAKGGVKA 177
Query: 51 KLHLRRANPSLFPSLQARGIRRVQILSLRRSLSYVIQGMA----NIESLNLSGCYNLTDN 106
+ L + L P+ ++ ++R+ ++ + + V++ + + L LSGC+ +T +
Sbjct: 178 EKKLLASLEWLMPNRFSQ-LQRLTLIHWKSQVHPVLKLVGECCPRLTFLKLSGCHGVTAD 236
Query: 107 GLGH------------------------AFVQEIGS-LRALNLSLCKQITDSSLGRIAQY 141
L +F++E GS +R L L+ Q T +
Sbjct: 237 ALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLGSC 296
Query: 142 LKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLAGMTRSAAEGC 201
L+VLE+ N + L L LQ+ L+ R L+ + + G + G
Sbjct: 297 CPQLQVLEVSTGINRNSIPLQLPVEALQK-GCPQLQVLRLLNLMWLPKPPGRGVAPGPGF 355
Query: 202 LGLEQLTL--QDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGL----------LHL 249
LE+L L C +++ L + G LRLL+L C I+ AGL LHL
Sbjct: 356 PSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQDLPCRELEQLHL 415
Query: 250 SHMGSLRSLNLRSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDG--- 306
G+ L L + T + L LSG F +K +Q+LA G
Sbjct: 416 GLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSG--QGFSEKDLEQALAAFLSTPGGSHP 473
Query: 307 -LKSLSLCSCHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLE 349
L SL+L ++ ++ ++ GL LN+ C R +GL+
Sbjct: 474 ALCSLNLRGTRVTPSTVSSVISSCPGLLYLNLESC-RCLPRGLK 516
>gi|54112382 F-box and leucine-rich repeat protein 10 isoform a [Homo
sapiens]
Length = 1336
Score = 54.7 bits (130), Expect = 2e-07
Identities = 64/279 (22%), Positives = 108/279 (38%), Gaps = 55/279 (19%)
Query: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70
E+ +F YL +D +VC W K +W ++ H + P L GI
Sbjct: 1068 EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLN-HCKSITP-----LMLSGI 1121
Query: 71 RRVQILSL--------RRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAF--------VQ 114
R Q +SL ++ LS++I + + L LSGC + + L + VQ
Sbjct: 1122 IRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQ 1181
Query: 115 EIGSLRALNL-SLCKQITDSSLGRI--AQYLKGLEVLELGGCSNITNTGLLLIAWGLQRL 171
+ L+ + L TD+ G++ L+ + L L G +IT+ L LI + L
Sbjct: 1182 WVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGL-DITDASLRLIIRHMPLL 1240
Query: 172 KSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLR 231
L+L C H++D I L + + + L
Sbjct: 1241 SKLHLSYCNHVTDQSINLLTAVGTTTRDS-----------------------------LT 1271
Query: 232 LLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTG 270
+NLS C ++D L G++ ++LR C ++ G
Sbjct: 1272 EINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEG 1310
Score = 52.0 bits (123), Expect = 1e-06
Identities = 56/219 (25%), Positives = 94/219 (42%), Gaps = 37/219 (16%)
Query: 185 VGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHIS---RGLTGLRLLNLSFCGGI 241
+ + H +T G + + ++L T++S K +S L GLR L LS C I
Sbjct: 1105 IDLNHCKSITPLMLSGIIRRQPVSLD--LSWTNISKKQLSWLINRLPGLRDLVLSGCSWI 1162
Query: 242 SDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLA-------------------MGSLRLS 282
+ + L S LR+L+++ + + D + L + LRL+
Sbjct: 1163 AVSALCS-SSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLA 1221
Query: 283 GLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSC-HISDDGINRMVR----QMHGLRTLNI 337
GLD++ D SL I + + L L L C H++D IN + L +N+
Sbjct: 1222 GLDIT------DASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINL 1275
Query: 338 GQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLER 376
C ++TD+ L + + IDL C ++TK G E+
Sbjct: 1276 SDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKEGCEQ 1313
>gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [Homo
sapiens]
Length = 1265
Score = 54.7 bits (130), Expect = 2e-07
Identities = 64/279 (22%), Positives = 108/279 (38%), Gaps = 55/279 (19%)
Query: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70
E+ +F YL +D +VC W K +W ++ H + P L GI
Sbjct: 999 EVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLN-HCKSITP-----LMLSGI 1052
Query: 71 RRVQILSL--------RRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAF--------VQ 114
R Q +SL ++ LS++I + + L LSGC + + L + VQ
Sbjct: 1053 IRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSALCSSSCPLLRTLDVQ 1112
Query: 115 EIGSLRALNL-SLCKQITDSSLGRI--AQYLKGLEVLELGGCSNITNTGLLLIAWGLQRL 171
+ L+ + L TD+ G++ L+ + L L G +IT+ L LI + L
Sbjct: 1113 WVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGL-DITDASLRLIIRHMPLL 1171
Query: 172 KSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLR 231
L+L C H++D I L + + + L
Sbjct: 1172 SKLHLSYCNHVTDQSINLLTAVGTTTRDS-----------------------------LT 1202
Query: 232 LLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTG 270
+NLS C ++D L G++ ++LR C ++ G
Sbjct: 1203 EINLSDCNKVTDQCLSFFKRCGNICHIDLRYCKQVTKEG 1241
Score = 52.0 bits (123), Expect = 1e-06
Identities = 56/219 (25%), Positives = 94/219 (42%), Gaps = 37/219 (16%)
Query: 185 VGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHIS---RGLTGLRLLNLSFCGGI 241
+ + H +T G + + ++L T++S K +S L GLR L LS C I
Sbjct: 1036 IDLNHCKSITPLMLSGIIRRQPVSLD--LSWTNISKKQLSWLINRLPGLRDLVLSGCSWI 1093
Query: 242 SDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLA-------------------MGSLRLS 282
+ + L S LR+L+++ + + D + L + LRL+
Sbjct: 1094 AVSALCS-SSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLA 1152
Query: 283 GLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSC-HISDDGINRMVR----QMHGLRTLNI 337
GLD++ D SL I + + L L L C H++D IN + L +N+
Sbjct: 1153 GLDIT------DASLRLIIRHMPLLSKLHLSYCNHVTDQSINLLTAVGTTTRDSLTEINL 1206
Query: 338 GQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLER 376
C ++TD+ L + + IDL C ++TK G E+
Sbjct: 1207 SDCNKVTDQCLSFF-KRCGNICHIDLRYCKQVTKEGCEQ 1244
>gi|16306580 F-box and leucine-rich repeat protein 11 [Homo sapiens]
Length = 1162
Score = 53.9 bits (128), Expect = 3e-07
Identities = 64/268 (23%), Positives = 109/268 (40%), Gaps = 34/268 (12%)
Query: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70
E+ +F YL R+ +VC W K +W K+ L R + +L GI
Sbjct: 896 EVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLW----TKIDLSRCKAIVPQALS--GI 949
Query: 71 RRVQILSL--------RRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRAL 122
+ Q +SL ++ L++++ + ++ L L+GC + + + LR L
Sbjct: 950 IKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGC---SWSAVSALSTSSCPLLRTL 1006
Query: 123 NLSLCKQITDSSLGRI------------AQYLKGLEVLELGGCSNITNTGLLLIAWGLQR 170
+L I D + + L+ + L G +IT+ L LI +
Sbjct: 1007 DLRWAVGIKDPQIRDLLTPPADKPGQDNRSKLRNMTDFRLAGL-DITDATLRLIIRHMPL 1065
Query: 171 LKSLNLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGL 230
L L+L C HL+D L + S L +L + C KLTD +L ++ R + +
Sbjct: 1066 LSRLDLSHCSHLTDQSSNLLTAVGSSTR---YSLTELNMAGCNKLTDQTLIYLRR-IANV 1121
Query: 231 RLLNLSFCGGISDAGLLHLSHMGSLRSL 258
L++L C I+ H S+ SL
Sbjct: 1122 TLIDLRGCKQITRKACEHFISDLSINSL 1149
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 39/199 (19%)
Query: 216 TDLSLKHIS---RGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDTGIM 272
T++S K ++ L GL+ L L+ C S L S LR+L+LR I D I
Sbjct: 962 TNISKKQLTWLVNRLPGLKDLLLAGCSW-SAVSALSTSSCPLLRTLDLRWAVGIKDPQIR 1020
Query: 273 HLA-----------------MGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSC 315
L M RL+GLD++ D +L I + + L L L C
Sbjct: 1021 DLLTPPADKPGQDNRSKLRNMTDFRLAGLDIT------DATLRLIIRHMPLLSRLDLSHC 1074
Query: 316 -HISDDGINRMVR----QMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRIT 370
H++D N + + L LN+ C ++TD+ L + ++ +T IDL GC +IT
Sbjct: 1075 SHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTL-IYLRRIANVTLIDLRGCKQIT 1133
Query: 371 KRGLER------ITQLPCL 383
++ E I L CL
Sbjct: 1134 RKACEHFISDLSINSLYCL 1152
>gi|16306584 F-box and leucine-rich repeat protein 3 [Homo sapiens]
Length = 428
Score = 51.6 bits (122), Expect = 1e-06
Identities = 53/208 (25%), Positives = 85/208 (40%), Gaps = 21/208 (10%)
Query: 8 LFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKL------HLRRANPSL 61
L +++ +F YL + D+ A+QVC W + +WR E +L +L+ +P L
Sbjct: 39 LLQDIILQVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPEL 98
Query: 62 FPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRA 121
+ R +Q +S + S + A LS N + LG I + R
Sbjct: 99 IKQIIKRHSNHLQYVSFKVDSS---KESAEAACDILSQLVNCSLKTLG-----LISTARP 150
Query: 122 LNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRH 181
+ L K S+L + K L L++ + +L+A LK L + SC H
Sbjct: 151 SFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPH 210
Query: 182 LSDVGIGHLAGMTRSAAEGCLGLEQLTL 209
+S GI A+ C GL +L L
Sbjct: 211 VSPAGI-------LCVADQCHGLRELAL 231
Score = 31.6 bits (70), Expect = 1.4
Identities = 21/46 (45%), Positives = 25/46 (54%), Gaps = 2/46 (4%)
Query: 292 VGDQSL-AYIAQGLDGLKSLSLCSC-HISDDGINRMVRQMHGLRTL 335
V D SL +A D LK L + SC H+S GI + Q HGLR L
Sbjct: 184 VDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLREL 229
>gi|8923179 F-box and leucine-rich repeat protein 12 [Homo sapiens]
Length = 326
Score = 50.8 bits (120), Expect = 2e-06
Identities = 76/285 (26%), Positives = 118/285 (41%), Gaps = 47/285 (16%)
Query: 12 LLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIR 71
+L IF YL VRD+ R ++VC W+ + +WR V+ L+ R
Sbjct: 11 VLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRP-------------- 56
Query: 72 RVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDN---GLGHAFVQEIGSLRALNLSLCK 128
+V LRR ++ + + SL + G Y + + L A ++ +G LC
Sbjct: 57 KVMWHLLRRYMA------SRLHSLRMGG-YLFSGSQAPQLSPALLRALGQKCPNLKRLCL 109
Query: 129 QITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAW--GLQRLKSLNLRSCRHLSDVG 186
+ D S+ I L LEL C + +AW Q L L C L V
Sbjct: 110 HVADLSMVPITSLPSTLRTLELHSCE-------ISMAWLHKQQDPTVLPLLECIVLDRVP 162
Query: 187 I---GHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISD 243
HL G+TR A L L L ++T+ L + L+ L+ L + C +D
Sbjct: 163 AFRDEHLQGLTRFRA-----LRSLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCTLSAD 217
Query: 244 AGLLHLS-HMGSLRSLNLRSCDNISDTGIMHL----AMGSLRLSG 283
+ LL +S H+ +R + L + +S G+ L A+ SL L G
Sbjct: 218 STLLAISRHLRDVRKIRL-TVRGLSAPGLAVLEGMPALESLCLQG 261
Score = 33.5 bits (75), Expect = 0.37
Identities = 28/113 (24%), Positives = 54/113 (47%), Gaps = 11/113 (9%)
Query: 261 RSCDNISDTGIMHLAMGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISD- 319
R C +++D ++ + L L++ C+ S+A++ + D L L C + D
Sbjct: 106 RLCLHVADLSMVPITSLPSTLRTLELHSCEI----SMAWLHKQQDPTV-LPLLECIVLDR 160
Query: 320 -----DGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCT 367
D + + + LR+L +G R+T+ GL+ + LS L +++ GCT
Sbjct: 161 VPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDAGLQELSYLQRLEVLGCT 213
>gi|122937219 F-box protein 41 [Homo sapiens]
Length = 936
Score = 49.7 bits (117), Expect = 5e-06
Identities = 70/276 (25%), Positives = 114/276 (41%), Gaps = 42/276 (15%)
Query: 10 PELLAM------IFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANP-SLF 62
PE+L M IF YLD R AA+VC WR A H +VW ++ L A S F
Sbjct: 609 PEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVW----TRVLLENARVCSKF 664
Query: 63 PSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRAL 122
++ A+ + L+L ++L +G + + GL G+L L
Sbjct: 665 LAMLAQWCTQAHSLTL-QNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLIL 723
Query: 123 NLSLCKQI-TDSSLGRIAQYLKGLEVLELGGCSN-ITNTGLLLIAWGLQRLKSLN---LR 177
+S C I TD SL + Y + L+ + ++ + + + + G + + SL L
Sbjct: 724 RISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVAPLH 783
Query: 178 SCR------------------HLSDVGIG----HLAGMTRSAAEGCLGLEQLTLQDCQKL 215
C+ HL +G+G + G+ S A C+ L+ L L ++
Sbjct: 784 PCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLA-SLARNCMRLQVLELDHVSEI 842
Query: 216 TDLSLKHISR-GLTGLRLLNLSFCGGISDAGLLHLS 250
T + R GL GL +L L+ ++ LLH +
Sbjct: 843 TQEVAAEVCREGLKGLEMLVLT-ATPVTPKALLHFN 877
>gi|16306595 S-phase kinase-associated protein 2 isoform 1 [Homo
sapiens]
Length = 424
Score = 45.1 bits (105), Expect = 1e-04
Identities = 63/277 (22%), Positives = 119/277 (42%), Gaps = 39/277 (14%)
Query: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70
ELL IF L + + + + VC W A +S+W+ ++ L + +P + L ++G
Sbjct: 103 ELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLD--LTGKNLHPDVTGRLLSQG- 159
Query: 71 RRVQILSLRRSLSYVIQGMA------NIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNL 124
+++ R S++ Q +A ++ ++LS ++ + H + + L+ L+L
Sbjct: 160 ----VIAFRCPRSFMDQPLAEHFSPFRVQHMDLSN--SVIEVSTLHGILSQCSKLQNLSL 213
Query: 125 SLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSD 184
+ ++D + +A+ L L L GCS + L + RL LNL C ++
Sbjct: 214 EGLR-LSDPIVNTLAKN-SNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTE 271
Query: 185 ----VGIGH---------LAGMTRSAAEG--------CLGLEQLTLQDCQKLTDLSLKHI 223
V + H L+G ++ + C L L L D L + +
Sbjct: 272 KHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEF 331
Query: 224 SRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNL 260
+ L L+ L+LS C I LL L + +L++L +
Sbjct: 332 FQ-LNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQV 367
Score = 43.1 bits (100), Expect = 5e-04
Identities = 46/184 (25%), Positives = 83/184 (45%), Gaps = 22/184 (11%)
Query: 209 LQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISD 268
L C KL +LSL+ GLRL SD + L+ +L LNL C S+
Sbjct: 202 LSQCSKLQNLSLE-------GLRL---------SDPIVNTLAKNSNLVRLNLSGCSGFSE 245
Query: 269 TGIMHLAMGSLRLSGLDVSFC----DKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINR 324
+ L RL L++S+C +K ++A++++ + L +LS ++ ++
Sbjct: 246 FALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQL-NLSGYRKNLQKSDLST 304
Query: 325 MVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQLPCLK 384
+VR+ L L++ V + + + + L+ L + L C I L + ++P LK
Sbjct: 305 LVRRCPNLVHLDLSDSVMLKNDCFQEFFQ-LNYLQHLSLSRCYDIIPETLLELGEIPTLK 363
Query: 385 VLNL 388
L +
Sbjct: 364 TLQV 367
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 43.1 bits (100), Expect = 5e-04
Identities = 45/124 (36%), Positives = 61/124 (49%), Gaps = 22/124 (17%)
Query: 175 NLRSCRHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQ--KLTDLSLKHISRGLTGLRL 232
+L S R L +VG L ++R A G L LE+LTL+ C L+ SL H+ R L LRL
Sbjct: 148 DLHSLRRL-EVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHL-RSLGALRL 205
Query: 233 LNLSFCGGISD------AGLLHLS----------HMGSLRSLNLRSCDNISDTGIMHLAM 276
+L+ + D GLLHL GSLR LNL S +++ T I +
Sbjct: 206 RHLAI-ASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSL-SVTHTNITAVPA 263
Query: 277 GSLR 280
+LR
Sbjct: 264 AALR 267
>gi|40788015 caspase recruitment domain protein 12 [Homo sapiens]
Length = 1024
Score = 42.7 bits (99), Expect = 6e-04
Identities = 67/279 (24%), Positives = 114/279 (40%), Gaps = 52/279 (18%)
Query: 170 RLKSLNLRSCRHLSDVGIGHLAGMTRSAAE---------GCLGLEQLTLQDCQKLTDLSL 220
R + LR L+ I +L + SA G G L L C+ + L +
Sbjct: 660 RTLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMV 719
Query: 221 ----------KHISRGLTGLRLL------NLSFCGGISDAGLLHLSHMGSLRSLNLRSCD 264
+HI+ +T L+ L N GG++D+ +G+L++L D
Sbjct: 720 EASPLTIEDERHIT-SVTNLKTLSIHDLQNQRLPGGLTDS-------LGNLKNLTKLIMD 771
Query: 265 NI--SDTGIMHLAMGSLRLSGLDVSFCDKVGD--QSLAYIAQGLDG----LKSLSLCSCH 316
NI ++ + LA G L + + + D + + YI + L L+ + L SC
Sbjct: 772 NIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCC 831
Query: 317 ISDDGINRMVRQMHGLRTLNIGQCVR--ITDKGLELIAEH------LSQLTGIDL-YGCT 367
+S + + + + +H L L+I + G E + E L QLT + L +GC
Sbjct: 832 LSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCD 891
Query: 368 RITKRG--LERITQLPCLKVLNLGLWQMTDSEKEARGDF 404
L+ + ++P L L L W++TD+E G F
Sbjct: 892 VQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAF 930
Score = 31.2 bits (69), Expect = 1.8
Identities = 45/176 (25%), Positives = 79/176 (44%), Gaps = 7/176 (3%)
Query: 61 LFPSLQARGIRRVQILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLR 120
+F S + ++ + + SLS V+ NI SL + LT H + + +L+
Sbjct: 683 IFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEAS-PLTIEDERH--ITSVTNLK 739
Query: 121 ALNL-SLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSC 179
L++ L Q L LK L L + + + +A GL+ LK + L
Sbjct: 740 TLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIK-MNEEDAIKLAEGLKNLKKMCLFHL 798
Query: 180 RHLSDVGIGHLAGMTRSAAEGCLGLEQLTLQDCQKLTDLSLKHISRGLTGLRLLNL 235
HLSD+G G + ++E C LE++ L C L+ ++K +++ L L L++
Sbjct: 799 THLSDIGEGMDYIVKSLSSEPC-DLEEIQLVSC-CLSANAVKILAQNLHNLVKLSI 852
>gi|14249170 S-phase kinase-associated protein 2 isoform 2 [Homo
sapiens]
Length = 410
Score = 41.2 bits (95), Expect = 0.002
Identities = 60/282 (21%), Positives = 119/282 (42%), Gaps = 32/282 (11%)
Query: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGI 70
ELL IF L + + + + VC W A +S+W+ ++ L + +P + L ++G
Sbjct: 103 ELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLD--LTGKNLHPDVTGRLLSQG- 159
Query: 71 RRVQILSLRRSLSYVIQGMA------NIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNL 124
+++ R S++ Q +A ++ ++LS ++ + H + + L+ L+L
Sbjct: 160 ----VIAFRCPRSFMDQPLAEHFSPFRVQHMDLSN--SVIEVSTLHGILSQCSKLQNLSL 213
Query: 125 SLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSD 184
+ ++D + +A+ L L L GCS + L + RL LNL C ++
Sbjct: 214 EGLR-LSDPIVNTLAKN-SNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTE 271
Query: 185 ----VGIGHLAGMTRSAAEGCLGLEQLTLQDCQK-LTDLSLKHISRGLTGLRLLNLSFCG 239
V + H++ + QL L +K L L + R L L+LS
Sbjct: 272 KHVQVAVAHVSET----------ITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSV 321
Query: 240 GISDAGLLHLSHMGSLRSLNLRSCDNISDTGIMHLAMGSLRL 281
+ + + L+ L+L C +I ++ + +R+
Sbjct: 322 MLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLLVTRAGVRI 363
Score = 36.6 bits (83), Expect = 0.043
Identities = 43/175 (24%), Positives = 78/175 (44%), Gaps = 22/175 (12%)
Query: 209 LQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISD 268
L C KL +LSL+ GLRL SD + L+ +L LNL C S+
Sbjct: 202 LSQCSKLQNLSLE-------GLRL---------SDPIVNTLAKNSNLVRLNLSGCSGFSE 245
Query: 269 TGIMHLAMGSLRLSGLDVSFC----DKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINR 324
+ L RL L++S+C +K ++A++++ + L +LS ++ ++
Sbjct: 246 FALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQL-NLSGYRKNLQKSDLST 304
Query: 325 MVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGLERITQ 379
+VR+ L L++ V + + + + L+ L + L C I L +T+
Sbjct: 305 LVRRCPNLVHLDLSDSVMLKNDCFQEFFQ-LNYLQHLSLSRCYDIIPETLLLVTR 358
>gi|194018550 c-Maf-inducing protein isoform C-mip [Homo sapiens]
Length = 773
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/108 (37%), Positives = 54/108 (50%), Gaps = 12/108 (11%)
Query: 172 KSLNLRSCRHLSDVGIGHLAGM-------TRSAAEGCL---GLEQLTLQDCQKLTDLSLK 221
KS + R LS G+L + T + AE + L+QL L Q D L+
Sbjct: 646 KSTDADLARLLSSGSFGNLENLSLAFTNVTSACAEHLIKLPSLKQLNLWSTQ-FGDAGLR 704
Query: 222 HISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDT 269
+S LT L++LNL ++DAGLL LS M SL SLN+ S +DT
Sbjct: 705 LLSEHLTMLQVLNLCETP-VTDAGLLALSSMKSLCSLNMNSTKLSADT 751
Score = 30.0 bits (66), Expect = 4.1
Identities = 41/155 (26%), Positives = 70/155 (45%), Gaps = 9/155 (5%)
Query: 210 QDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDT 269
Q C + +L G T L L + S + A LL G+L +L+L + N++
Sbjct: 621 QLCDRQRELKELQRKGGPTRLTLPSKSTDADL--ARLLSSGSFGNLENLSL-AFTNVTSA 677
Query: 270 GIMHLA-MGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQ 328
HL + SL+ L + + GD L +++ L L+ L+LC ++D G+ +
Sbjct: 678 CAEHLIKLPSLKQLNL---WSTQFGDAGLRLLSEHLTMLQVLNLCETPVTDAGL-LALSS 733
Query: 329 MHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDL 363
M L +LN+ D +L A+ L L +D+
Sbjct: 734 MKSLCSLNMNSTKLSADTYEDLKAK-LPNLKEVDV 767
>gi|29789255 c-Maf-inducing protein isoform Tc-mip [Homo sapiens]
Length = 679
Score = 41.2 bits (95), Expect = 0.002
Identities = 40/108 (37%), Positives = 54/108 (50%), Gaps = 12/108 (11%)
Query: 172 KSLNLRSCRHLSDVGIGHLAGM-------TRSAAEGCL---GLEQLTLQDCQKLTDLSLK 221
KS + R LS G+L + T + AE + L+QL L Q D L+
Sbjct: 552 KSTDADLARLLSSGSFGNLENLSLAFTNVTSACAEHLIKLPSLKQLNLWSTQ-FGDAGLR 610
Query: 222 HISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDT 269
+S LT L++LNL ++DAGLL LS M SL SLN+ S +DT
Sbjct: 611 LLSEHLTMLQVLNLCETP-VTDAGLLALSSMKSLCSLNMNSTKLSADT 657
Score = 30.0 bits (66), Expect = 4.1
Identities = 41/155 (26%), Positives = 70/155 (45%), Gaps = 9/155 (5%)
Query: 210 QDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSCDNISDT 269
Q C + +L G T L L + S + A LL G+L +L+L + N++
Sbjct: 527 QLCDRQRELKELQRKGGPTRLTLPSKSTDADL--ARLLSSGSFGNLENLSL-AFTNVTSA 583
Query: 270 GIMHLA-MGSLRLSGLDVSFCDKVGDQSLAYIAQGLDGLKSLSLCSCHISDDGINRMVRQ 328
HL + SL+ L + + GD L +++ L L+ L+LC ++D G+ +
Sbjct: 584 CAEHLIKLPSLKQLNL---WSTQFGDAGLRLLSEHLTMLQVLNLCETPVTDAGL-LALSS 639
Query: 329 MHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDL 363
M L +LN+ D +L A+ L L +D+
Sbjct: 640 MKSLCSLNMNSTKLSADTYEDLKAK-LPNLKEVDV 673
>gi|22547146 F-box and leucine-rich repeat protein 8 [Homo
sapiens]
Length = 374
Score = 41.2 bits (95), Expect = 0.002
Identities = 18/35 (51%), Positives = 25/35 (71%)
Query: 11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVW 45
E+LA+IF +L +RD+ AA+VC AW AA +VW
Sbjct: 11 EVLALIFRHLSLRDRAAAARVCRAWAAAATCSAVW 45
>gi|8922303 ATP5S-like [Homo sapiens]
Length = 257
Score = 40.0 bits (92), Expect = 0.004
Identities = 22/71 (30%), Positives = 38/71 (53%)
Query: 204 LEQLTLQDCQKLTDLSLKHISRGLTGLRLLNLSFCGGISDAGLLHLSHMGSLRSLNLRSC 263
L+ L+LQ C + D L + L+ L+L+ C IS+ GL L H+ +LR L++
Sbjct: 150 LQSLSLQRCSHVDDWCLSRLYPLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDL 209
Query: 264 DNISDTGIMHL 274
+S+ G+ +
Sbjct: 210 PAVSNPGLTQI 220
Score = 37.4 bits (85), Expect = 0.025
Identities = 21/74 (28%), Positives = 42/74 (56%), Gaps = 1/74 (1%)
Query: 315 CHISDDGINRMVRQMHGLRTLNIGQCVRITDKGLELIAEHLSQLTGIDLYGCTRITKRGL 374
C I+ +G++ ++R + L++L++ +C + D L + L + L GC RI++RGL
Sbjct: 134 CDINYEGLDNLLR-LKELQSLSLQRCSHVDDWCLSRLYPLADSLQELSLAGCPRISERGL 192
Query: 375 ERITQLPCLKVLNL 388
+ L L+ L++
Sbjct: 193 ACLHHLQNLRRLDI 206
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,975,087
Number of Sequences: 37866
Number of extensions: 546668
Number of successful extensions: 1673
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 1135
Number of HSP's gapped (non-prelim): 196
length of query: 418
length of database: 18,247,518
effective HSP length: 105
effective length of query: 313
effective length of database: 14,271,588
effective search space: 4467007044
effective search space used: 4467007044
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.