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Search of human proteins with 226495417
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226495417 coiled-coil domain containing 102A [Homo sapiens]
(550 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226495417 coiled-coil domain containing 102A [Homo sapiens] 1076 0.0
gi|147905592 coiled-coil domain containing 102B [Homo sapiens] 370 e-102
gi|148233522 coiled-coil domain containing 102B [Homo sapiens] 370 e-102
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 124 2e-28
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 119 5e-27
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 119 5e-27
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 119 5e-27
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 119 5e-27
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 119 5e-27
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 115 1e-25
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 115 1e-25
gi|31982906 cingulin-like 1 [Homo sapiens] 115 1e-25
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 105 1e-22
gi|16262452 cingulin [Homo sapiens] 104 2e-22
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 98 2e-20
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 97 5e-20
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 97 5e-20
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 97 5e-20
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 97 5e-20
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 97 5e-20
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 97 5e-20
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 97 5e-20
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 97 5e-20
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 93 7e-19
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 92 2e-18
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 91 2e-18
gi|45439327 periplakin [Homo sapiens] 91 2e-18
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 89 8e-18
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 88 2e-17
gi|148746195 trichohyalin [Homo sapiens] 86 7e-17
>gi|226495417 coiled-coil domain containing 102A [Homo sapiens]
Length = 550
Score = 1076 bits (2783), Expect = 0.0
Identities = 550/550 (100%), Positives = 550/550 (100%)
Query: 1 MSHGPSPRLAESPQLSKGSLLTILGSPSPERMGPADSLPPTPPSGTPSPGPPPALPLPPA 60
MSHGPSPRLAESPQLSKGSLLTILGSPSPERMGPADSLPPTPPSGTPSPGPPPALPLPPA
Sbjct: 1 MSHGPSPRLAESPQLSKGSLLTILGSPSPERMGPADSLPPTPPSGTPSPGPPPALPLPPA 60
Query: 61 PALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRARE 120
PALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRARE
Sbjct: 61 PALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRARE 120
Query: 121 EVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAER 180
EVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAER
Sbjct: 121 EVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAER 180
Query: 181 EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWE 240
EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWE
Sbjct: 181 EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWE 240
Query: 241 DTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKT 300
DTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKT
Sbjct: 241 DTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKT 300
Query: 301 KQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGR 360
KQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGR
Sbjct: 301 KQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGR 360
Query: 361 RERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELAD 420
RERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELAD
Sbjct: 361 RERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELAD 420
Query: 421 LKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQ 480
LKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQ
Sbjct: 421 LKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQ 480
Query: 481 ARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLD 540
ARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLD
Sbjct: 481 ARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLD 540
Query: 541 EDEDLQIQVA 550
EDEDLQIQVA
Sbjct: 541 EDEDLQIQVA 550
>gi|147905592 coiled-coil domain containing 102B [Homo sapiens]
Length = 513
Score = 370 bits (950), Expect = e-102
Identities = 212/449 (47%), Positives = 297/449 (66%), Gaps = 13/449 (2%)
Query: 69 WESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQR 128
W+ EELRLRELEE +ARAAQMEKTMR WSDCTANWREKWSKVRAERN AREE RQLR +
Sbjct: 67 WDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIK 126
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP--------EAER 180
L+ KEL+ ++ +Q + EA + + G +++ + + E+ R
Sbjct: 127 LEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIR 185
Query: 181 EPV--RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLP 238
E + R ++ ++E +V LK + EE + + L G G+ + RL
Sbjct: 186 EYLVKRQFSTKEDTNNKEQGVVIDSLK-LSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK 244
Query: 239 WEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELS 298
E E ++++AL++ LDE QK+L KERE + AL + IE+LE LS WK KYEEL
Sbjct: 245 -AINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
Query: 299 KTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEW 358
++K + +K+ IL H DE+ +S ++++E +++S DR + ELR E+ERLQAEN +EW
Sbjct: 304 ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
Query: 359 GRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKEL 418
+RE LE EK GLEREN++L+ QV ++EE L ++ R +A++ D + SQ L EKN+EL
Sbjct: 364 DKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQEL 423
Query: 419 ADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAH 478
+L+H + KL +Q+Q +AEL HAN RV+Q+EAEVKKLRLRVEELK+ L Q EDELD++
Sbjct: 424 LNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSL 483
Query: 479 NQARKLQRSLDEQTEQSENLQVQLEHLQS 507
NQ RKLQRSLDE+ E++ENL+ +L HLQ+
Sbjct: 484 NQIRKLQRSLDEEKERNENLETELRHLQN 512
Score = 38.1 bits (87), Expect = 0.021
Identities = 66/325 (20%), Positives = 128/325 (39%), Gaps = 39/325 (12%)
Query: 214 CWEARSLGAGGPRGSSGRQERSRLPWED-TAATEEEASKLTA-----------LRLRLDE 261
C E R + + + E++ W D TA E+ SK+ A LR++L+
Sbjct: 70 CEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEM 129
Query: 262 SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQD---- 317
+ K L ++ K +L E LE ++Q +K + E Q + + H+
Sbjct: 130 AMKELSTLKK-KQSLPPQKEALEANVTQ-DLKLPGFVEESCEHTDQFQLSSQMHESIREY 187
Query: 318 ----ELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE-----RLETEK 368
+ + E G + E++ ++ + N G E RL+
Sbjct: 188 LVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAIN 247
Query: 369 LGLERENKKLRAQVGDLEE--ALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHG 426
L LE E ++ A L+E + + R+ +AL+ ++ ++AL + +LK
Sbjct: 248 LPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
Query: 427 KLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQR 486
K K+F + QH E+++L ++E K + + E + +LQ
Sbjct: 308 KNVKEFDILLG----------QHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQA 357
Query: 487 SLDEQTEQSENLQVQLEHLQSRLRR 511
+ ++ E L+ + + L+ RR
Sbjct: 358 ENTSEWDKREILEREKQGLERENRR 382
>gi|148233522 coiled-coil domain containing 102B [Homo sapiens]
Length = 513
Score = 370 bits (950), Expect = e-102
Identities = 212/449 (47%), Positives = 297/449 (66%), Gaps = 13/449 (2%)
Query: 69 WESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQR 128
W+ EELRLRELEE +ARAAQMEKTMR WSDCTANWREKWSKVRAERN AREE RQLR +
Sbjct: 67 WDICEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIK 126
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP--------EAER 180
L+ KEL+ ++ +Q + EA + + G +++ + + E+ R
Sbjct: 127 LEMAMKELSTLKK-KQSLPPQKEALEANVTQDLKLPGFVEESCEHTDQFQLSSQMHESIR 185
Query: 181 EPV--RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLP 238
E + R ++ ++E +V LK + EE + + L G G+ + RL
Sbjct: 186 EYLVKRQFSTKEDTNNKEQGVVIDSLK-LSEEMKPNLDGVDLFNNGGSGNGETKTGLRLK 244
Query: 239 WEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELS 298
E E ++++AL++ LDE QK+L KERE + AL + IE+LE LS WK KYEEL
Sbjct: 245 -AINLPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELK 303
Query: 299 KTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEW 358
++K + +K+ IL H DE+ +S ++++E +++S DR + ELR E+ERLQAEN +EW
Sbjct: 304 ESKPKNVKEFDILLGQHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQAENTSEW 363
Query: 359 GRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKEL 418
+RE LE EK GLEREN++L+ QV ++EE L ++ R +A++ D + SQ L EKN+EL
Sbjct: 364 DKREILEREKQGLERENRRLKIQVKEMEELLDKKNRLSANSQSPDFKMSQIDLQEKNQEL 423
Query: 419 ADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAH 478
+L+H + KL +Q+Q +AEL HAN RV+Q+EAEVKKLRLRVEELK+ L Q EDELD++
Sbjct: 424 LNLQHAYYKLNRQYQANIAELTHANNRVDQNEAEVKKLRLRVEELKQGLNQKEDELDDSL 483
Query: 479 NQARKLQRSLDEQTEQSENLQVQLEHLQS 507
NQ RKLQRSLDE+ E++ENL+ +L HLQ+
Sbjct: 484 NQIRKLQRSLDEEKERNENLETELRHLQN 512
Score = 38.1 bits (87), Expect = 0.021
Identities = 66/325 (20%), Positives = 128/325 (39%), Gaps = 39/325 (12%)
Query: 214 CWEARSLGAGGPRGSSGRQERSRLPWED-TAATEEEASKLTA-----------LRLRLDE 261
C E R + + + E++ W D TA E+ SK+ A LR++L+
Sbjct: 70 CEELRLRELEEVKARAAQMEKTMRWWSDCTANWREKWSKVRAERNSAREEGRQLRIKLEM 129
Query: 262 SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQD---- 317
+ K L ++ K +L E LE ++Q +K + E Q + + H+
Sbjct: 130 AMKELSTLKK-KQSLPPQKEALEANVTQ-DLKLPGFVEESCEHTDQFQLSSQMHESIREY 187
Query: 318 ----ELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE-----RLETEK 368
+ + E G + E++ ++ + N G E RL+
Sbjct: 188 LVKRQFSTKEDTNNKEQGVVIDSLKLSEEMKPNLDGVDLFNNGGSGNGETKTGLRLKAIN 247
Query: 369 LGLERENKKLRAQVGDLEE--ALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHG 426
L LE E ++ A L+E + + R+ +AL+ ++ ++AL + +LK
Sbjct: 248 LPLENEVTEISALQVHLDEFQKILWKEREMRTALEKEIERLESALSLWKWKYEELKESKP 307
Query: 427 KLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQR 486
K K+F + QH E+++L ++E K + + E + +LQ
Sbjct: 308 KNVKEFDILLG----------QHNDEMQELSGNIKEESKSQNSKDRVICELRAELERLQA 357
Query: 487 SLDEQTEQSENLQVQLEHLQSRLRR 511
+ ++ E L+ + + L+ RR
Sbjct: 358 ENTSEWDKREILEREKQGLERENRR 382
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 124 bits (312), Expect = 2e-28
Identities = 128/503 (25%), Positives = 234/503 (46%), Gaps = 51/503 (10%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRL 129
E++EE R+ ++ RA ME M D N E RA ++V ++R +L
Sbjct: 1497 EAKEEFE-RQNKQLRA---DMEDLMSSKDDVGKNVHELEKSKRA----LEQQVEEMRTQL 1548
Query: 130 DALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAER---EPVRDV 186
+ L EL + + +A + R QTRD E +R + VR++
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQAMKAQFERDL-------QTRDEQNEEKKRLLIKQVREL 1601
Query: 187 GSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATE 246
+E ++ L + K M + +D EA+ A R +Q R A +
Sbjct: 1602 EAELEDERKQRALAVASKKKMEIDLKDL-EAQIEAANKARDEVIKQLRKL-----QAQMK 1655
Query: 247 EEASKLTALRLRLDESQKVLLKEREDKL-ALSRNIEKLEGELSQWKIKYEELSKTKQEML 305
+ +L R DE KE E KL +L I +L+ EL+ + + + E+
Sbjct: 1656 DYQRELEEARASRDEIF-AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 306 KQLS--------ILKEAHQDE--LGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENA 355
+++ +L E + E + ++ E+LE+E ++ + + +++ L AE A
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 356 AEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKN 415
AE ++ + + LER+NK+L+A++ +LE A+ + + T SAL+ + + L ++
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 416 KELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELD 475
KE A + + +K+ +E ++ R +Q++ +++K R+++LK++L +AE+E
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEAT 1894
Query: 476 EAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPL-FGKIRSAR-------- 526
A+ RKLQR LD+ TE +E L ++ L++RLRR P+ F RS R
Sbjct: 1895 RANASRRKLQRELDDATEANEGLSREVSTLKNRLRR---GGPISFSSSRSGRRQLHLEGA 1951
Query: 527 ---FGTEEAEDGTSDLDEDEDLQ 546
++ E TSD++E + Q
Sbjct: 1952 SLELSDDDTESKTSDVNETQPPQ 1974
Score = 77.4 bits (189), Expect = 3e-14
Identities = 125/550 (22%), Positives = 217/550 (39%), Gaps = 101/550 (18%)
Query: 78 RELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELA 137
R+ EE +A+ ++ K +EK +KV E + +QL + + L ++L
Sbjct: 849 RQEEELQAKDEELLKV-----------KEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 897
Query: 138 GARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPV-------------- 183
EA+ E R R A+ + + E E ER +
Sbjct: 898 AETELFAEAE---EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQD 954
Query: 184 -RDVGSERPPGSQELEL----VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLP 238
+ E Q+L+L E+ +K M EE + S + ++R
Sbjct: 955 LEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFI---KEKKLMEDRIAEC 1011
Query: 239 WEDTAATEEEASKLTALR----LRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKY 294
A EE+A L +R + + + ++ L KE + + L + KL+GE + + +
Sbjct: 1012 SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 295 EELSKTKQEMLKQLSILKEAHQDELGR------------------------MSEDLEDEL 330
EL E+ QL+ +E Q L R + ED E E
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 331 GARSSMDRKMAELRGEMERLQAE-------NAAEWGRRERLETE----KLGLERENKKLR 379
+R+ +++ +L E+E L+ E AA+ R + E E K LE E K
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Query: 380 AQVGDLEEALARRRRQTASALD------CDLRASQAALFEKNKELA-----------DLK 422
AQ+ D+ + A + + L+ +L ++ L NKELA + +
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 423 HVHGKLKKQFQEKVAELAHANR-RVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQA 481
H KL Q QE A+++ +R RVE E + KL+ ++ + L +AE + + A
Sbjct: 1252 HKRKKLDAQVQELHAKVSEGDRLRVELAE-KASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 482 RKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDE 541
L+ L + E + Q +L SR+R+ ++ S + EE E+ +L++
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK------NSLQEQQEEEEEARKNLEK 1364
Query: 542 DE-DLQIQVA 550
LQ Q+A
Sbjct: 1365 QVLALQSQLA 1374
Score = 77.4 bits (189), Expect = 3e-14
Identities = 111/471 (23%), Positives = 200/471 (42%), Gaps = 77/471 (16%)
Query: 92 KTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECE 151
K +R A +E + +A RN+A ++ R L + L+AL EL Q
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170
Query: 152 ARGRELARLRGA-----------------------RGVADQTRDGPEPEAEREPVRDVGS 188
R +E+A L+ A +++Q +A E + G
Sbjct: 1171 KREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ-GL 1229
Query: 189 ERPPGSQELELVESLLKSMPEESEDCW-----EARSLGAGGPRGSSGRQE----RSRLPW 239
E ++EL +L+ + ESE + + L A G R E S+L
Sbjct: 1230 ETD--NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN 1287
Query: 240 E--DTAATEEEASK--------LTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQ 289
E + + EEA K +L +L ++Q++L +E KL LS I +LE E +
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Query: 290 WKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMER 349
+ + EE + ++ + KQ+ L Q +L + ++D+LG S++ +L + E
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLAL----QSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403
Query: 350 LQAENAAEWGRRERLETEKLG---LERENKKLRAQVGDLEEALARRRRQTASALDCDLRA 406
L +RLE + L LE+ +L+ ++ DL L +RQ AS L+ +
Sbjct: 1404 LS----------QRLEEKALAYDKLEKTKNRLQQELDDLTVDL-DHQRQVASNLEKKQKK 1452
Query: 407 SQAALFEKNKELADLKHVHGKLKKQFQEKVAE-------LAHANRRVEQHEAEVKKLRLR 459
L E+ A + + + +EK + L A E+ E + K+LR
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD 1512
Query: 460 VEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLR 510
+E +L ++D++ + ++ K +R+L++Q E+ ++ QLE L+ L+
Sbjct: 1513 ME----DLMSSKDDVGKNVHELEKSKRALEQQVEE---MRTQLEELEDELQ 1556
Score = 71.6 bits (174), Expect = 2e-12
Identities = 72/301 (23%), Positives = 139/301 (46%), Gaps = 31/301 (10%)
Query: 257 LRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQ 316
L++ ++ L + E+ L + K+EGEL EE+ + Q++L++ +IL E Q
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVEGEL-------EEMERKHQQLLEEKNILAEQLQ 897
Query: 317 DELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENK 376
E +E E R+ + K EL + L++ E R + L+ EK K
Sbjct: 898 AETELFAEAEE----MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK-------K 946
Query: 377 KLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKL---KKQFQ 433
K++A + DLEE L L + ++A + + +E+ L+ + K KK +
Sbjct: 947 KMQAHIQDLEEQL-DEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Query: 434 EKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQT- 492
+++AE + E+ + K+R + E + +L + + ++ + K +R LD +T
Sbjct: 1006 DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETT 1065
Query: 493 ---EQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQV 549
+Q LQ Q++ L+ +L ++++ L G + G +E + L +LQ Q+
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEE--LQGALAR---GDDETLHKNNALKVVRELQAQI 1120
Query: 550 A 550
A
Sbjct: 1121 A 1121
Score = 59.7 bits (143), Expect = 7e-09
Identities = 108/501 (21%), Positives = 205/501 (40%), Gaps = 62/501 (12%)
Query: 71 SREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLD 130
+++E+ + +LEE R + EKT + K+ E ++++ +L+ ++D
Sbjct: 1030 NKQEVMISDLEE---RLKKEEKTRQELEKAKR-------KLDGETTDLQDQIAELQAQID 1079
Query: 131 ALTKELAGARRERQEA--QGECEARGRELARLRGARGVADQTRDGPEP-EAEREPVRDVG 187
L +LA E Q A +G+ E + A L+ R + Q + E E+E+
Sbjct: 1080 ELKLQLAKKEEELQGALARGDDETLHKNNA-LKVVRELQAQIAELQEDFESEKASRNKAE 1138
Query: 188 SERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEE 247
++ S+ELE +++ L+ + + E R+ QE + L T+
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRT---------KREQEVAELKKALEEETKN 1189
Query: 248 EASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQE 303
+++ +R R L+E + L + + K L +N + LE + + + + L + K E
Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1249
Query: 304 MLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRER 363
+ L Q+ ++SE DR EL + +LQ E E
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEG-----------DRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 364 LETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKH 423
E + + ++ L +Q+ D +E L RQ + L +R + ++ + +
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEKNSLQEQQEEEEE 1357
Query: 424 VHGKLKKQFQEKVAELAHANRRV-------EQHEAEVKKLRLRVEELKKEL---AQAEDE 473
L+KQ ++LA ++V E E KKL E L + L A A D+
Sbjct: 1358 ARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 474 LDEAHNQARK----LQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGT 529
L++ N+ ++ L LD Q + + NL+ + + L + K SAR+
Sbjct: 1418 LEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEE--------KSISARY-A 1468
Query: 530 EEAEDGTSDLDEDEDLQIQVA 550
EE + ++ E E + +A
Sbjct: 1469 EERDRAEAEAREKETKALSLA 1489
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 119 bits (299), Expect = 5e-27
Identities = 121/531 (22%), Positives = 233/531 (43%), Gaps = 68/531 (12%)
Query: 79 ELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAG 138
+LE+ R + +EK R++ A + + ER RA E R+ R +LT+ L
Sbjct: 1460 DLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEE 1519
Query: 139 ARRERQEAQ-------GECEAR-------GRELARLRGARGVADQTRDGPEPEA------ 178
+ R+E + E EA G+ + L A VA+Q + +
Sbjct: 1520 EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE 1579
Query: 179 ------------------EREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSL 220
+ + RD+ G + + L+ E ++ + R+L
Sbjct: 1580 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1639
Query: 221 GAGGPRGSSGRQERSRLPWEDTAATEEEASK-LTALRLRLDE-----------SQKVLLK 268
+ G E + +EEA K L ++ ++ E +++ +
Sbjct: 1640 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1699
Query: 269 EREDKL---ALSRNIEKLEGELSQWKIKYEELSKTKQEM--------LKQLSILKEAHQD 317
RE + L + +L+ EL+ + + + EM L + +IL+E Q
Sbjct: 1700 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1759
Query: 318 E--LGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
E LG++ E+LE+E ++ + +L ++E L E +AE + E+ + LER+
Sbjct: 1760 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1819
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEK 435
++LR ++G+ + R + T +AL+ L ++ L ++ +E + + +K+ +E
Sbjct: 1820 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1879
Query: 436 VAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQS 495
V ++ R +Q +++K LRV++LK++L +AE+E A R+LQR L++ TE +
Sbjct: 1880 VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESA 1939
Query: 496 ENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQ 546
E++ ++ L++RLRR PL R+ R E+G + +E E+ Q
Sbjct: 1940 ESMNREVTTLRNRLRR----GPLTFTTRTVR-QVFRLEEGVASDEEAEEAQ 1985
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/497 (22%), Positives = 189/497 (38%), Gaps = 47/497 (9%)
Query: 73 EELRLR------ELEEARARA-------AQMEKTMRRWSDCTANWREKWSKVRAERNRAR 119
EELR + EL+ A ARA AQ+ K++R A +E R R +A
Sbjct: 1104 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE 1163
Query: 120 EEVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAE 179
++ R L + L+AL EL Q R +E+ L+ + + E
Sbjct: 1164 KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELR 1223
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
+ + +G EL E L ++ + WE L S R E S L
Sbjct: 1224 QRHGQALG----------ELAEQLEQA--RRGKGAWEKTRLALEA-EVSELRAELSSLQ- 1269
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSK 299
A +E + L L+L E Q + + +++ + EL E
Sbjct: 1270 ---TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAES 1326
Query: 300 TKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWG 359
+ K+LS + D + E+ +L S + AE G E+L+ E AA
Sbjct: 1327 KTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER 1386
Query: 360 RRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELA 419
L+T + L ++ + G LE RRR A A L EK + +
Sbjct: 1387 AGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA-----EALTQRLAEKTETVD 1441
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHN 479
L+ +L+++ + +L + V E + +K + E K + +A +E + A
Sbjct: 1442 RLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEA 1501
Query: 480 QARK-------LQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKI-----RSARF 527
+ R+ L R+L+E+ E E L+ Q L++ L + GK R+ R
Sbjct: 1502 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1561
Query: 528 GTEEAEDGTSDLDEDED 544
+ A D + + E ED
Sbjct: 1562 AEQAANDLRAQVTELED 1578
Score = 80.1 bits (196), Expect = 5e-15
Identities = 127/527 (24%), Positives = 218/527 (41%), Gaps = 93/527 (17%)
Query: 71 SREELRLRELEEARARAAQMEKT----MRRWSDCTANWREKWSKVRAERNRARE-EVRQL 125
+R + R+ +++ R Q +R W W ++KV+ R+ EV Q
Sbjct: 827 ARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQ-----WWRLFTKVKPLLQVTRQDEVLQA 881
Query: 126 R-QRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVR 184
R Q L + + + RE E QG E ARL A+Q R E AE E R
Sbjct: 882 RAQELQKVQELQQQSAREVGELQGRVAQLEEERARL------AEQLRAEAELCAEAEETR 935
Query: 185 DVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE-RSRLPWEDTA 243
+ R QELELV S L++ E E+C +R + R QE + L E+ A
Sbjct: 936 GRLAAR---KQELELVVSELEARVGEEEEC--SRQMQTEKKRLQQHIQELEAHLEAEEGA 990
Query: 244 ATEEEASKLTA-LRLRLDESQKVLLKEREDKLALSRNI---------------EKLEGEL 287
+ + K+T +++ E +LL+++ KL+ R + E+ L
Sbjct: 991 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1050
Query: 288 SQWKIKYE------------------ELSKTKQEMLKQLSILKEAHQDE----------L 319
++ ++KYE EL K K+ + + S L+E ++ L
Sbjct: 1051 NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1110
Query: 320 GRMSEDL-------EDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLE 372
GR E+L EDE GAR+ + + + E + + Q + +E R + E ++ L
Sbjct: 1111 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1170
Query: 373 RENKKLRAQVGDLEEALARRRRQTASALDCDLRAS-QAALFEKNKELADLKHVH----GK 427
E + LR G+LE+ L Q +LR+ + + E K L + +H +
Sbjct: 1171 EELEALR---GELEDTLDSTNAQQ------ELRSKREQEVTELKKTLEEETRIHEAAVQE 1221
Query: 428 LKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVE----ELKKELAQAEDELDEAHNQARK 483
L+++ + + ELA + + + +K RL +E EL+ EL+ + E + R+
Sbjct: 1222 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1281
Query: 484 LQRSLDE-QTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGT 529
L+ L E Q + + + E + R Q + + G + A T
Sbjct: 1282 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1328
Score = 79.3 bits (194), Expect = 8e-15
Identities = 99/459 (21%), Positives = 193/459 (42%), Gaps = 22/459 (4%)
Query: 57 LPPAPALLADG--DWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAE 114
L A A LA+ D ES R + ++ R ++E D T + ++R++
Sbjct: 1138 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELED-TLDSTNAQQELRSK 1196
Query: 115 RNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEAR-GRELARLRGARGVADQTRDG 173
R +EV +L++ L+ T+ A +E ++ G+ +L + R +G ++TR
Sbjct: 1197 RE---QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLA 1253
Query: 174 PEPEAE--REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
E E R + + + R G Q +E L+ + + D AR+ A + +
Sbjct: 1254 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAE 1313
Query: 232 QER-SRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQW 290
E S E + T + +L++ +L ++Q++L +E KLAL + +E E +
Sbjct: 1314 LENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL 1373
Query: 291 KIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL 350
+ + EE + ++ ++L + Q +L E+E GA + + E E L
Sbjct: 1374 REQLEEEAAARERAGREL----QTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1429
Query: 351 QAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAA 410
A + +RLE + L++E L DLE+ +RQ S L+ R
Sbjct: 1430 TQRLAEKTETVDRLERGRRRLQQE---LDDATMDLEQ-----QRQLVSTLEKKQRKFDQL 1481
Query: 411 LFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQA 470
L E+ + + + + +E+ A R +E+ + ++L + L+ EL
Sbjct: 1482 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1541
Query: 471 EDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRL 509
D+ +L+R+ + + +L+ Q+ L+ L
Sbjct: 1542 LSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1580
Score = 67.8 bits (164), Expect = 2e-11
Identities = 72/304 (23%), Positives = 139/304 (45%), Gaps = 56/304 (18%)
Query: 255 LRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEA 314
L+ R E QKV +++ +R + +L+G ++Q + EE ++ +++ + + EA
Sbjct: 879 LQARAQELQKVQELQQQS----AREVGELQGRVAQLE---EERARLAEQLRAEAELCAEA 931
Query: 315 HQ---------DELGRMSEDLEDELGARSSMDRKMA----ELRGEMERLQAENAAEWGRR 361
+ EL + +LE +G R+M L+ ++ L+A AE G R
Sbjct: 932 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 991
Query: 362 ERLETEKLGLERENKKLRAQVGDLEE---ALARRRRQTASALDCDLRASQAALFEKNKEL 418
++L+ EK+ E + KK + LE+ L++ R+ L + + A EK K L
Sbjct: 992 QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL-AEFSSQAAEEEEKVKSL 1050
Query: 419 ADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAH 478
KL+ +++ +A++ R+ E+ E++KL+ R++
Sbjct: 1051 -------NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLD----------------- 1086
Query: 479 NQARKLQRSLDEQTEQSENLQVQL----EHLQSRLRRQQQ----NAPLFGKIRSARFGTE 530
++ +LQ + EQ +++E L+ QL E LQ+ L R + A L +R A+
Sbjct: 1087 GESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA 1146
Query: 531 EAED 534
EA++
Sbjct: 1147 EAQE 1150
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 119 bits (299), Expect = 5e-27
Identities = 121/531 (22%), Positives = 233/531 (43%), Gaps = 68/531 (12%)
Query: 79 ELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAG 138
+LE+ R + +EK R++ A + + ER RA E R+ R +LT+ L
Sbjct: 1452 DLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEE 1511
Query: 139 ARRERQEAQ-------GECEAR-------GRELARLRGARGVADQTRDGPEPEA------ 178
+ R+E + E EA G+ + L A VA+Q + +
Sbjct: 1512 EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE 1571
Query: 179 ------------------EREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSL 220
+ + RD+ G + + L+ E ++ + R+L
Sbjct: 1572 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1631
Query: 221 GAGGPRGSSGRQERSRLPWEDTAATEEEASK-LTALRLRLDE-----------SQKVLLK 268
+ G E + +EEA K L ++ ++ E +++ +
Sbjct: 1632 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1691
Query: 269 EREDKL---ALSRNIEKLEGELSQWKIKYEELSKTKQEM--------LKQLSILKEAHQD 317
RE + L + +L+ EL+ + + + EM L + +IL+E Q
Sbjct: 1692 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1751
Query: 318 E--LGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
E LG++ E+LE+E ++ + +L ++E L E +AE + E+ + LER+
Sbjct: 1752 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1811
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEK 435
++LR ++G+ + R + T +AL+ L ++ L ++ +E + + +K+ +E
Sbjct: 1812 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1871
Query: 436 VAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQS 495
V ++ R +Q +++K LRV++LK++L +AE+E A R+LQR L++ TE +
Sbjct: 1872 VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESA 1931
Query: 496 ENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQ 546
E++ ++ L++RLRR PL R+ R E+G + +E E+ Q
Sbjct: 1932 ESMNREVTTLRNRLRR----GPLTFTTRTVR-QVFRLEEGVASDEEAEEAQ 1977
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/497 (22%), Positives = 189/497 (38%), Gaps = 47/497 (9%)
Query: 73 EELRLR------ELEEARARA-------AQMEKTMRRWSDCTANWREKWSKVRAERNRAR 119
EELR + EL+ A ARA AQ+ K++R A +E R R +A
Sbjct: 1096 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE 1155
Query: 120 EEVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAE 179
++ R L + L+AL EL Q R +E+ L+ + + E
Sbjct: 1156 KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELR 1215
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
+ + +G EL E L ++ + WE L S R E S L
Sbjct: 1216 QRHGQALG----------ELAEQLEQA--RRGKGAWEKTRLALEA-EVSELRAELSSLQ- 1261
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSK 299
A +E + L L+L E Q + + +++ + EL E
Sbjct: 1262 ---TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAES 1318
Query: 300 TKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWG 359
+ K+LS + D + E+ +L S + AE G E+L+ E AA
Sbjct: 1319 KTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER 1378
Query: 360 RRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELA 419
L+T + L ++ + G LE RRR A A L EK + +
Sbjct: 1379 AGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA-----EALTQRLAEKTETVD 1433
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHN 479
L+ +L+++ + +L + V E + +K + E K + +A +E + A
Sbjct: 1434 RLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEA 1493
Query: 480 QARK-------LQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKI-----RSARF 527
+ R+ L R+L+E+ E E L+ Q L++ L + GK R+ R
Sbjct: 1494 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1553
Query: 528 GTEEAEDGTSDLDEDED 544
+ A D + + E ED
Sbjct: 1554 AEQAANDLRAQVTELED 1570
Score = 80.1 bits (196), Expect = 5e-15
Identities = 127/527 (24%), Positives = 218/527 (41%), Gaps = 93/527 (17%)
Query: 71 SREELRLRELEEARARAAQMEKT----MRRWSDCTANWREKWSKVRAERNRARE-EVRQL 125
+R + R+ +++ R Q +R W W ++KV+ R+ EV Q
Sbjct: 819 ARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQ-----WWRLFTKVKPLLQVTRQDEVLQA 873
Query: 126 R-QRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVR 184
R Q L + + + RE E QG E ARL A+Q R E AE E R
Sbjct: 874 RAQELQKVQELQQQSAREVGELQGRVAQLEEERARL------AEQLRAEAELCAEAEETR 927
Query: 185 DVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE-RSRLPWEDTA 243
+ R QELELV S L++ E E+C +R + R QE + L E+ A
Sbjct: 928 GRLAAR---KQELELVVSELEARVGEEEEC--SRQMQTEKKRLQQHIQELEAHLEAEEGA 982
Query: 244 ATEEEASKLTA-LRLRLDESQKVLLKEREDKLALSRNI---------------EKLEGEL 287
+ + K+T +++ E +LL+++ KL+ R + E+ L
Sbjct: 983 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1042
Query: 288 SQWKIKYE------------------ELSKTKQEMLKQLSILKEAHQDE----------L 319
++ ++KYE EL K K+ + + S L+E ++ L
Sbjct: 1043 NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1102
Query: 320 GRMSEDL-------EDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLE 372
GR E+L EDE GAR+ + + + E + + Q + +E R + E ++ L
Sbjct: 1103 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1162
Query: 373 RENKKLRAQVGDLEEALARRRRQTASALDCDLRAS-QAALFEKNKELADLKHVH----GK 427
E + LR G+LE+ L Q +LR+ + + E K L + +H +
Sbjct: 1163 EELEALR---GELEDTLDSTNAQQ------ELRSKREQEVTELKKTLEEETRIHEAAVQE 1213
Query: 428 LKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVE----ELKKELAQAEDELDEAHNQARK 483
L+++ + + ELA + + + +K RL +E EL+ EL+ + E + R+
Sbjct: 1214 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1273
Query: 484 LQRSLDE-QTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGT 529
L+ L E Q + + + E + R Q + + G + A T
Sbjct: 1274 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1320
Score = 79.3 bits (194), Expect = 8e-15
Identities = 99/459 (21%), Positives = 193/459 (42%), Gaps = 22/459 (4%)
Query: 57 LPPAPALLADG--DWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAE 114
L A A LA+ D ES R + ++ R ++E D T + ++R++
Sbjct: 1130 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELED-TLDSTNAQQELRSK 1188
Query: 115 RNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEAR-GRELARLRGARGVADQTRDG 173
R +EV +L++ L+ T+ A +E ++ G+ +L + R +G ++TR
Sbjct: 1189 RE---QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLA 1245
Query: 174 PEPEAE--REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
E E R + + + R G Q +E L+ + + D AR+ A + +
Sbjct: 1246 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAE 1305
Query: 232 QER-SRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQW 290
E S E + T + +L++ +L ++Q++L +E KLAL + +E E +
Sbjct: 1306 LENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL 1365
Query: 291 KIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL 350
+ + EE + ++ ++L + Q +L E+E GA + + E E L
Sbjct: 1366 REQLEEEAAARERAGREL----QTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1421
Query: 351 QAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAA 410
A + +RLE + L++E L DLE+ +RQ S L+ R
Sbjct: 1422 TQRLAEKTETVDRLERGRRRLQQE---LDDATMDLEQ-----QRQLVSTLEKKQRKFDQL 1473
Query: 411 LFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQA 470
L E+ + + + + +E+ A R +E+ + ++L + L+ EL
Sbjct: 1474 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1533
Query: 471 EDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRL 509
D+ +L+R+ + + +L+ Q+ L+ L
Sbjct: 1534 LSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1572
Score = 67.8 bits (164), Expect = 2e-11
Identities = 72/304 (23%), Positives = 139/304 (45%), Gaps = 56/304 (18%)
Query: 255 LRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEA 314
L+ R E QKV +++ +R + +L+G ++Q + EE ++ +++ + + EA
Sbjct: 871 LQARAQELQKVQELQQQS----AREVGELQGRVAQLE---EERARLAEQLRAEAELCAEA 923
Query: 315 HQ---------DELGRMSEDLEDELGARSSMDRKMA----ELRGEMERLQAENAAEWGRR 361
+ EL + +LE +G R+M L+ ++ L+A AE G R
Sbjct: 924 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 983
Query: 362 ERLETEKLGLERENKKLRAQVGDLEE---ALARRRRQTASALDCDLRASQAALFEKNKEL 418
++L+ EK+ E + KK + LE+ L++ R+ L + + A EK K L
Sbjct: 984 QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL-AEFSSQAAEEEEKVKSL 1042
Query: 419 ADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAH 478
KL+ +++ +A++ R+ E+ E++KL+ R++
Sbjct: 1043 -------NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLD----------------- 1078
Query: 479 NQARKLQRSLDEQTEQSENLQVQL----EHLQSRLRRQQQ----NAPLFGKIRSARFGTE 530
++ +LQ + EQ +++E L+ QL E LQ+ L R + A L +R A+
Sbjct: 1079 GESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA 1138
Query: 531 EAED 534
EA++
Sbjct: 1139 EAQE 1142
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 119 bits (299), Expect = 5e-27
Identities = 121/531 (22%), Positives = 233/531 (43%), Gaps = 68/531 (12%)
Query: 79 ELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAG 138
+LE+ R + +EK R++ A + + ER RA E R+ R +LT+ L
Sbjct: 1493 DLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEE 1552
Query: 139 ARRERQEAQ-------GECEAR-------GRELARLRGARGVADQTRDGPEPEA------ 178
+ R+E + E EA G+ + L A VA+Q + +
Sbjct: 1553 EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE 1612
Query: 179 ------------------EREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSL 220
+ + RD+ G + + L+ E ++ + R+L
Sbjct: 1613 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1672
Query: 221 GAGGPRGSSGRQERSRLPWEDTAATEEEASK-LTALRLRLDE-----------SQKVLLK 268
+ G E + +EEA K L ++ ++ E +++ +
Sbjct: 1673 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1732
Query: 269 EREDKL---ALSRNIEKLEGELSQWKIKYEELSKTKQEM--------LKQLSILKEAHQD 317
RE + L + +L+ EL+ + + + EM L + +IL+E Q
Sbjct: 1733 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1792
Query: 318 E--LGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
E LG++ E+LE+E ++ + +L ++E L E +AE + E+ + LER+
Sbjct: 1793 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1852
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEK 435
++LR ++G+ + R + T +AL+ L ++ L ++ +E + + +K+ +E
Sbjct: 1853 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1912
Query: 436 VAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQS 495
V ++ R +Q +++K LRV++LK++L +AE+E A R+LQR L++ TE +
Sbjct: 1913 VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESA 1972
Query: 496 ENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQ 546
E++ ++ L++RLRR PL R+ R E+G + +E E+ Q
Sbjct: 1973 ESMNREVTTLRNRLRR----GPLTFTTRTVR-QVFRLEEGVASDEEAEEAQ 2018
Score = 83.2 bits (204), Expect = 6e-16
Identities = 114/497 (22%), Positives = 189/497 (38%), Gaps = 47/497 (9%)
Query: 73 EELRLR------ELEEARARA-------AQMEKTMRRWSDCTANWREKWSKVRAERNRAR 119
EELR + EL+ A ARA AQ+ K++R A +E R R +A
Sbjct: 1137 EELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE 1196
Query: 120 EEVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAE 179
++ R L + L+AL EL Q R +E+ L+ + + E
Sbjct: 1197 KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELR 1256
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
+ + +G EL E L ++ + WE L S R E S L
Sbjct: 1257 QRHGQALG----------ELAEQLEQA--RRGKGAWEKTRLALEA-EVSELRAELSSLQ- 1302
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSK 299
A +E + L L+L E Q + + +++ + EL E
Sbjct: 1303 ---TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAES 1359
Query: 300 TKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWG 359
+ K+LS + D + E+ +L S + AE G E+L+ E AA
Sbjct: 1360 KTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARER 1419
Query: 360 RRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELA 419
L+T + L ++ + G LE RRR A A L EK + +
Sbjct: 1420 AGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREA-----EALTQRLAEKTETVD 1474
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHN 479
L+ +L+++ + +L + V E + +K + E K + +A +E + A
Sbjct: 1475 RLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEA 1534
Query: 480 QARK-------LQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKI-----RSARF 527
+ R+ L R+L+E+ E E L+ Q L++ L + GK R+ R
Sbjct: 1535 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1594
Query: 528 GTEEAEDGTSDLDEDED 544
+ A D + + E ED
Sbjct: 1595 AEQAANDLRAQVTELED 1611
Score = 80.1 bits (196), Expect = 5e-15
Identities = 127/527 (24%), Positives = 218/527 (41%), Gaps = 93/527 (17%)
Query: 71 SREELRLRELEEARARAAQMEKT----MRRWSDCTANWREKWSKVRAERNRARE-EVRQL 125
+R + R+ +++ R Q +R W W ++KV+ R+ EV Q
Sbjct: 860 ARRAFQKRQQQQSALRVMQRNCAAYLKLRHWQ-----WWRLFTKVKPLLQVTRQDEVLQA 914
Query: 126 R-QRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVR 184
R Q L + + + RE E QG E ARL A+Q R E AE E R
Sbjct: 915 RAQELQKVQELQQQSAREVGELQGRVAQLEEERARL------AEQLRAEAELCAEAEETR 968
Query: 185 DVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE-RSRLPWEDTA 243
+ R QELELV S L++ E E+C +R + R QE + L E+ A
Sbjct: 969 GRLAAR---KQELELVVSELEARVGEEEEC--SRQMQTEKKRLQQHIQELEAHLEAEEGA 1023
Query: 244 ATEEEASKLTA-LRLRLDESQKVLLKEREDKLALSRNI---------------EKLEGEL 287
+ + K+T +++ E +LL+++ KL+ R + E+ L
Sbjct: 1024 RQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSL 1083
Query: 288 SQWKIKYE------------------ELSKTKQEMLKQLSILKEAHQDE----------L 319
++ ++KYE EL K K+ + + S L+E ++ L
Sbjct: 1084 NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1143
Query: 320 GRMSEDL-------EDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLE 372
GR E+L EDE GAR+ + + + E + + Q + +E R + E ++ L
Sbjct: 1144 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1203
Query: 373 RENKKLRAQVGDLEEALARRRRQTASALDCDLRAS-QAALFEKNKELADLKHVH----GK 427
E + LR G+LE+ L Q +LR+ + + E K L + +H +
Sbjct: 1204 EELEALR---GELEDTLDSTNAQQ------ELRSKREQEVTELKKTLEEETRIHEAAVQE 1254
Query: 428 LKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVE----ELKKELAQAEDELDEAHNQARK 483
L+++ + + ELA + + + +K RL +E EL+ EL+ + E + R+
Sbjct: 1255 LRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1314
Query: 484 LQRSLDE-QTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGT 529
L+ L E Q + + + E + R Q + + G + A T
Sbjct: 1315 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1361
Score = 79.3 bits (194), Expect = 8e-15
Identities = 99/459 (21%), Positives = 193/459 (42%), Gaps = 22/459 (4%)
Query: 57 LPPAPALLADG--DWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAE 114
L A A LA+ D ES R + ++ R ++E D T + ++R++
Sbjct: 1171 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELED-TLDSTNAQQELRSK 1229
Query: 115 RNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEAR-GRELARLRGARGVADQTRDG 173
R +EV +L++ L+ T+ A +E ++ G+ +L + R +G ++TR
Sbjct: 1230 RE---QEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLA 1286
Query: 174 PEPEAE--REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
E E R + + + R G Q +E L+ + + D AR+ A + +
Sbjct: 1287 LEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAE 1346
Query: 232 QER-SRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQW 290
E S E + T + +L++ +L ++Q++L +E KLAL + +E E +
Sbjct: 1347 LENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGL 1406
Query: 291 KIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL 350
+ + EE + ++ ++L + Q +L E+E GA + + E E L
Sbjct: 1407 REQLEEEAAARERAGREL----QTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1462
Query: 351 QAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAA 410
A + +RLE + L++E L DLE+ +RQ S L+ R
Sbjct: 1463 TQRLAEKTETVDRLERGRRRLQQE---LDDATMDLEQ-----QRQLVSTLEKKQRKFDQL 1514
Query: 411 LFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQA 470
L E+ + + + + +E+ A R +E+ + ++L + L+ EL
Sbjct: 1515 LAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEAL 1574
Query: 471 EDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRL 509
D+ +L+R+ + + +L+ Q+ L+ L
Sbjct: 1575 LSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1613
Score = 67.8 bits (164), Expect = 2e-11
Identities = 72/304 (23%), Positives = 139/304 (45%), Gaps = 56/304 (18%)
Query: 255 LRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEA 314
L+ R E QKV +++ +R + +L+G ++Q + EE ++ +++ + + EA
Sbjct: 912 LQARAQELQKVQELQQQS----AREVGELQGRVAQLE---EERARLAEQLRAEAELCAEA 964
Query: 315 HQ---------DELGRMSEDLEDELGARSSMDRKMA----ELRGEMERLQAENAAEWGRR 361
+ EL + +LE +G R+M L+ ++ L+A AE G R
Sbjct: 965 EETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGAR 1024
Query: 362 ERLETEKLGLERENKKLRAQVGDLEE---ALARRRRQTASALDCDLRASQAALFEKNKEL 418
++L+ EK+ E + KK + LE+ L++ R+ L + + A EK K L
Sbjct: 1025 QKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRL-AEFSSQAAEEEEKVKSL 1083
Query: 419 ADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAH 478
KL+ +++ +A++ R+ E+ E++KL+ R++
Sbjct: 1084 -------NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLD----------------- 1119
Query: 479 NQARKLQRSLDEQTEQSENLQVQL----EHLQSRLRRQQQ----NAPLFGKIRSARFGTE 530
++ +LQ + EQ +++E L+ QL E LQ+ L R + A L +R A+
Sbjct: 1120 GESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALA 1179
Query: 531 EAED 534
EA++
Sbjct: 1180 EAQE 1183
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 119 bits (299), Expect = 5e-27
Identities = 121/529 (22%), Positives = 234/529 (44%), Gaps = 71/529 (13%)
Query: 79 ELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAG 138
+L+ R + +EK R++ A + SK ER+RA E R+ + +L + L
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 139 ARRERQEAQGECEARGRELARLRGAR-----GVADQTRDGPEPEAEREPV---------- 183
A ++E + + E+ L ++ V + + E + E +
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 184 -----------------------RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSL 220
RD+ + ++ ++ L E ED + R+L
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 221 GAGGPRGSSGRQERSRLPWEDTAATEEEASK-LTALRLRLDESQKVL------------- 266
A + G + L + EEA K L L+ ++ + Q+ L
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 267 LKEREDKL-ALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSIL---KEAHQDE---- 318
KE E K +L ++ +L+ +L+ + ++ K+E+ ++L+ + A QDE
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 319 ---LGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
+ ++ E+LE+E G +M ++ + + E+L E A E ++ E+ + LER+N
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEK 435
K+LR+++ ++E A+ + + T +AL+ + A L E+ ++ A K K KQ +K
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKI----AQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 436 VAELA----HANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ 491
+ E+ + EQ++ + +K RV++LK++L +AE+E + RKLQR LDE
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 492 TEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLD 540
TE +E + ++ L+S+LRR + + + + R E A+ + D
Sbjct: 1911 TESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETD 1959
Score = 101 bits (252), Expect = 2e-21
Identities = 121/487 (24%), Positives = 217/487 (44%), Gaps = 65/487 (13%)
Query: 78 RELEEARARAAQMEKTMRRWSDCTANWRE---KWSKVRAERNRARE----------EVRQ 124
R+ EE +A+ +++KT R +E K S++ E+N +E E +
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 125 LRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVR 184
+R RL A +EL E + E E RG++L R + +A Q D E E E R
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER--KKMAQQMLDLEEQLEEEEAAR 966
Query: 185 D-VGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTA 243
+ E+ +++ +E + M +++ + R L +ER + A
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL----------LEERISDLTTNLA 1016
Query: 244 ATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSK 299
EE+A LT L+ + + E + L KE + + L + KLEG+ S + + +L
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 300 TKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWG 359
E+ QL+ +E Q L R L+DE+ +++ +K+ EL G + LQ + +E
Sbjct: 1077 QIAELKMQLAKKEEELQAALAR----LDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 360 RRERLETEKLGLERENKKLRAQVGDL-------EEALARRRRQTA---SALDCDLRASQA 409
R + E +K L E + L+ ++ D +E A+R ++ ALD + R+ +A
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 410 -----------ALFEKNKELADLKHVHGKL---KKQFQEKVAELAHANRRVEQHEAEV-- 453
A+ E ++L K L K+ +++ A+LA R + Q + EV
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 454 --KKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQT---EQSENLQVQLEHLQSR 508
KKL +V+EL+ + + E E +++ KLQ ++ T ++E ++L +
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 509 LRRQQQN 515
L Q Q+
Sbjct: 1313 LSSQLQD 1319
Score = 75.1 bits (183), Expect = 2e-13
Identities = 102/470 (21%), Positives = 198/470 (42%), Gaps = 77/470 (16%)
Query: 71 SREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAE-------RNRAREEVR 123
S E+RL++ E++R ++EK R+ +++ E+ + ++A+ + EE++
Sbjct: 1037 SELEVRLKKEEKSRQ---ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093
Query: 124 QLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPV 183
RLD + A ++ +E +G +L R AR A++ +
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK------------ 1141
Query: 184 RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTA 243
RD+G E L+++ E ED + S+ Q+ R A
Sbjct: 1142 RDLGEE--------------LEALKTELEDTLD-----------STATQQELR------A 1170
Query: 244 ATEEEASKLTALRLRLDE---SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKT 300
E+E +T L+ LDE S + ++E K A + +E+L +L Q+K L K
Sbjct: 1171 KREQE---VTVLKKALDEETRSHEAQVQEMRQKHA--QAVEELTEQLEQFKRAKANLDKN 1225
Query: 301 KQEMLK-------QLSILKEAHQD---ELGRMSEDLEDELGARSSMDRKMAELRGEMERL 350
KQ + K +L +L +A Q+ + ++ +++ S +R AEL ++ +L
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 351 QAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASA------LDCDL 404
Q E + G E + + L ++ L +Q+ D +E L RQ + L+ +
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ Q L E+ + +L+ L Q + +L VE E K+ + +E L
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 465 KELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQ 514
++ + D+ +LQ+ LD+ +N + + +L+ + R+ Q
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Score = 71.6 bits (174), Expect = 2e-12
Identities = 91/448 (20%), Positives = 190/448 (42%), Gaps = 32/448 (7%)
Query: 96 RWSDCTANWREKWSKVR---AERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEA 152
R SD T N E+ K + +N+ + +L RL K + +++ +G+
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 153 RGRELARLRGARGVADQTRDGPEPEAEREPVR--DVGSERPPGSQELELVESLLKSMPEE 210
++A L+ E E + R D +++ +++ +E + + E+
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 211 SEDCWEARSLGAGGPRGSSGRQERSRLPWEDT---AATEEEA-----SKLTALRLRLDE- 261
+ AR+ R E + EDT AT++E ++T L+ LDE
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 262 --SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQ-------LSILK 312
S + ++E K A + +E+L +L Q+K L K KQ + K+ L +L
Sbjct: 1187 TRSHEAQVQEMRQKHAQA--VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244
Query: 313 EAHQD---ELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKL 369
+A Q+ + ++ +++ S +R AEL ++ +LQ E + G E + +
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 370 GLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLK 429
L ++ L +Q+ D +E L RQ + + LR + +L + L+
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 430 KQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLD 489
+ +L+ + ++++ + V+ L + +KE+ + +E KL+++ +
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 490 EQTEQSENLQVQLEH---LQSRLRRQQQ 514
++ ++L V L++ L S L ++Q+
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/539 (22%), Positives = 215/539 (39%), Gaps = 101/539 (18%)
Query: 81 EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGAR 140
EE R+ AQ+++ ++ + E+ + + RA+ + + +Q L+ +LAG
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFK----RAKANLDKNKQTLEKENADLAGEL 1240
Query: 141 RERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAE-REPVRDVGSERPPGSQELEL 199
R +A+ E E + ++L + + + DG AE + V + +E
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQ--VQELQSKCSDGERARAELNDKVHKLQNE---------- 1288
Query: 200 VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRLRL 259
VES+ M E+E +A L SS Q+ L E+T ++KL L
Sbjct: 1289 VESVT-GMLNEAEG--KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 260 DESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDEL 319
+ Q L +E E K L R+I L +LS K K ++ + T ++ L K+ Q E+
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST----VEALEEGKKRFQKEI 1401
Query: 320 GRMSEDLEDELGARSSMDRKMAELRGEMERL------QAENAAEWGRRERLETEKLGLER 373
+++ E++ A +++ L+ E++ L Q + + +++R + L E+
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 374 ENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQ 433
A D EA AR + A +L RA + AL K +L+ + LK + +
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKE----ELERTNKMLKAEME 1514
Query: 434 EKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELD---------EAHNQA--- 481
+ V+ + V + E + L ++EE+K +L + EDEL E + QA
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 482 -----------------RKLQRSLDEQTEQSEN-----------------------LQV- 500
R+LQR L E + E+ LQ
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 501 -----------QLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQ 548
QL LQ++++ Q+ R F T + + + E + +Q+Q
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Score = 69.7 bits (169), Expect = 7e-12
Identities = 96/503 (19%), Positives = 206/503 (40%), Gaps = 58/503 (11%)
Query: 68 DWESRE-ELRLRELEEARARAAQ-MEKTMRRWSDCTANWREKWSKVRAER---------- 115
D E+R E +++E+ + A+A + + + + ++ AN + + E
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 116 NRAREEVRQLRQRLDALTKELAGARRERQEAQGEC-------------------EARGRE 156
+A++EV +++L+A +EL + + A+ E EA G+
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 157 LARLRGARGVADQTRDGPEP------------------EAEREPVRDVGSERPPGSQELE 198
+ + ++ Q +D E E ER ++D E Q LE
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 199 LVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEAS---KLTAL 255
S L +S+ + + + G++ + T EE+A+ KL
Sbjct: 1364 RHISTLNIQLSDSKK--KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1421
Query: 256 RLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAH 315
+ RL + L+ + +++ L N+EK + + Q + + +S + +
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 316 QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
+ + ++ LE+ L A+ ++R L+ EME L + LE K LE +
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGK--LKKQFQ 433
++++ Q+ +LE+ L + L+ +++A + FE++ + D ++ + L++Q
Sbjct: 1542 EEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLH 1599
Query: 434 EKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTE 493
E EL ++ A KKL +++L+ + A +EA Q RKLQ + +
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659
Query: 494 QSENLQVQLEHLQSRLRRQQQNA 516
+ E+ + + + + + ++ A
Sbjct: 1660 ELEDARASRDEIFATAKENEKKA 1682
Score = 36.2 bits (82), Expect = 0.080
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 435 KVAELAHANRRVEQHEA---EVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ 491
KV L R+ E+ +A E++K + R ++ + EL EL++ H+Q + + L EQ
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK----ELEQKHSQLTEEKNLLQEQ 895
Query: 492 TEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQ 548
+ L + E ++ RL ++Q AR EE ED L + Q
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL--EEEEDRGQQLQAERKKMAQ 950
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 119 bits (299), Expect = 5e-27
Identities = 121/529 (22%), Positives = 234/529 (44%), Gaps = 71/529 (13%)
Query: 79 ELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAG 138
+L+ R + +EK R++ A + SK ER+RA E R+ + +L + L
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 139 ARRERQEAQGECEARGRELARLRGAR-----GVADQTRDGPEPEAEREPV---------- 183
A ++E + + E+ L ++ V + + E + E +
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 184 -----------------------RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSL 220
RD+ + ++ ++ L E ED + R+L
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 221 GAGGPRGSSGRQERSRLPWEDTAATEEEASK-LTALRLRLDESQKVL------------- 266
A + G + L + EEA K L L+ ++ + Q+ L
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 267 LKEREDKL-ALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSIL---KEAHQDE---- 318
KE E K +L ++ +L+ +L+ + ++ K+E+ ++L+ + A QDE
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 319 ---LGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
+ ++ E+LE+E G +M ++ + + E+L E A E ++ E+ + LER+N
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEK 435
K+LR+++ ++E A+ + + T +AL+ + A L E+ ++ A K K KQ +K
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKI----AQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 436 VAELA----HANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ 491
+ E+ + EQ++ + +K RV++LK++L +AE+E + RKLQR LDE
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 492 TEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLD 540
TE +E + ++ L+S+LRR + + + + R E A+ + D
Sbjct: 1918 TESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETD 1966
Score = 101 bits (252), Expect = 2e-21
Identities = 121/487 (24%), Positives = 217/487 (44%), Gaps = 65/487 (13%)
Query: 78 RELEEARARAAQMEKTMRRWSDCTANWRE---KWSKVRAERNRARE----------EVRQ 124
R+ EE +A+ +++KT R +E K S++ E+N +E E +
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 125 LRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVR 184
+R RL A +EL E + E E RG++L R + +A Q D E E E R
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER--KKMAQQMLDLEEQLEEEEAAR 973
Query: 185 D-VGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTA 243
+ E+ +++ +E + M +++ + R L +ER + A
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL----------LEERISDLTTNLA 1023
Query: 244 ATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSK 299
EE+A LT L+ + + E + L KE + + L + KLEG+ S + + +L
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 300 TKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWG 359
E+ QL+ +E Q L R L+DE+ +++ +K+ EL G + LQ + +E
Sbjct: 1084 QIAELKMQLAKKEEELQAALAR----LDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 360 RRERLETEKLGLERENKKLRAQVGDL-------EEALARRRRQTA---SALDCDLRASQA 409
R + E +K L E + L+ ++ D +E A+R ++ ALD + R+ +A
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 410 -----------ALFEKNKELADLKHVHGKL---KKQFQEKVAELAHANRRVEQHEAEV-- 453
A+ E ++L K L K+ +++ A+LA R + Q + EV
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 454 --KKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQT---EQSENLQVQLEHLQSR 508
KKL +V+EL+ + + E E +++ KLQ ++ T ++E ++L +
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 509 LRRQQQN 515
L Q Q+
Sbjct: 1320 LSSQLQD 1326
Score = 75.1 bits (183), Expect = 2e-13
Identities = 102/470 (21%), Positives = 198/470 (42%), Gaps = 77/470 (16%)
Query: 71 SREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAE-------RNRAREEVR 123
S E+RL++ E++R ++EK R+ +++ E+ + ++A+ + EE++
Sbjct: 1044 SELEVRLKKEEKSRQ---ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Query: 124 QLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPV 183
RLD + A ++ +E +G +L R AR A++ +
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK------------ 1148
Query: 184 RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTA 243
RD+G E L+++ E ED + S+ Q+ R A
Sbjct: 1149 RDLGEE--------------LEALKTELEDTLD-----------STATQQELR------A 1177
Query: 244 ATEEEASKLTALRLRLDE---SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKT 300
E+E +T L+ LDE S + ++E K A + +E+L +L Q+K L K
Sbjct: 1178 KREQE---VTVLKKALDEETRSHEAQVQEMRQKHA--QAVEELTEQLEQFKRAKANLDKN 1232
Query: 301 KQEMLK-------QLSILKEAHQD---ELGRMSEDLEDELGARSSMDRKMAELRGEMERL 350
KQ + K +L +L +A Q+ + ++ +++ S +R AEL ++ +L
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 351 QAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASA------LDCDL 404
Q E + G E + + L ++ L +Q+ D +E L RQ + L+ +
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ Q L E+ + +L+ L Q + +L VE E K+ + +E L
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 465 KELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQ 514
++ + D+ +LQ+ LD+ +N + + +L+ + R+ Q
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Score = 71.6 bits (174), Expect = 2e-12
Identities = 91/448 (20%), Positives = 190/448 (42%), Gaps = 32/448 (7%)
Query: 96 RWSDCTANWREKWSKVR---AERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEA 152
R SD T N E+ K + +N+ + +L RL K + +++ +G+
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 153 RGRELARLRGARGVADQTRDGPEPEAEREPVR--DVGSERPPGSQELELVESLLKSMPEE 210
++A L+ E E + R D +++ +++ +E + + E+
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 211 SEDCWEARSLGAGGPRGSSGRQERSRLPWEDT---AATEEEA-----SKLTALRLRLDE- 261
+ AR+ R E + EDT AT++E ++T L+ LDE
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 262 --SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQ-------LSILK 312
S + ++E K A + +E+L +L Q+K L K KQ + K+ L +L
Sbjct: 1194 TRSHEAQVQEMRQKHAQA--VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1251
Query: 313 EAHQD---ELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKL 369
+A Q+ + ++ +++ S +R AEL ++ +LQ E + G E + +
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 370 GLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLK 429
L ++ L +Q+ D +E L RQ + + LR + +L + L+
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 430 KQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLD 489
+ +L+ + ++++ + V+ L + +KE+ + +E KL+++ +
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 490 EQTEQSENLQVQLEH---LQSRLRRQQQ 514
++ ++L V L++ L S L ++Q+
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/539 (22%), Positives = 215/539 (39%), Gaps = 101/539 (18%)
Query: 81 EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGAR 140
EE R+ AQ+++ ++ + E+ + + RA+ + + +Q L+ +LAG
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFK----RAKANLDKNKQTLEKENADLAGEL 1247
Query: 141 RERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAE-REPVRDVGSERPPGSQELEL 199
R +A+ E E + ++L + + + DG AE + V + +E
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQ--VQELQSKCSDGERARAELNDKVHKLQNE---------- 1295
Query: 200 VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRLRL 259
VES+ M E+E +A L SS Q+ L E+T ++KL L
Sbjct: 1296 VESVT-GMLNEAEG--KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 260 DESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDEL 319
+ Q L +E E K L R+I L +LS K K ++ + T ++ L K+ Q E+
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST----VEALEEGKKRFQKEI 1408
Query: 320 GRMSEDLEDELGARSSMDRKMAELRGEMERL------QAENAAEWGRRERLETEKLGLER 373
+++ E++ A +++ L+ E++ L Q + + +++R + L E+
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 374 ENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQ 433
A D EA AR + A +L RA + AL K +L+ + LK + +
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKE----ELERTNKMLKAEME 1521
Query: 434 EKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELD---------EAHNQA--- 481
+ V+ + V + E + L ++EE+K +L + EDEL E + QA
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 482 -----------------RKLQRSLDEQTEQSEN-----------------------LQV- 500
R+LQR L E + E+ LQ
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 501 -----------QLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQ 548
QL LQ++++ Q+ R F T + + + E + +Q+Q
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Score = 69.7 bits (169), Expect = 7e-12
Identities = 96/503 (19%), Positives = 206/503 (40%), Gaps = 58/503 (11%)
Query: 68 DWESRE-ELRLRELEEARARAAQ-MEKTMRRWSDCTANWREKWSKVRAER---------- 115
D E+R E +++E+ + A+A + + + + ++ AN + + E
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 116 NRAREEVRQLRQRLDALTKELAGARRERQEAQGEC-------------------EARGRE 156
+A++EV +++L+A +EL + + A+ E EA G+
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 157 LARLRGARGVADQTRDGPEP------------------EAEREPVRDVGSERPPGSQELE 198
+ + ++ Q +D E E ER ++D E Q LE
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 199 LVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEAS---KLTAL 255
S L +S+ + + + G++ + T EE+A+ KL
Sbjct: 1371 RHISTLNIQLSDSKK--KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1428
Query: 256 RLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAH 315
+ RL + L+ + +++ L N+EK + + Q + + +S + +
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 316 QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
+ + ++ LE+ L A+ ++R L+ EME L + LE K LE +
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGK--LKKQFQ 433
++++ Q+ +LE+ L + L+ +++A + FE++ + D ++ + L++Q
Sbjct: 1549 EEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLH 1606
Query: 434 EKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTE 493
E EL ++ A KKL +++L+ + A +EA Q RKLQ + +
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 494 QSENLQVQLEHLQSRLRRQQQNA 516
+ E+ + + + + + ++ A
Sbjct: 1667 ELEDARASRDEIFATAKENEKKA 1689
Score = 36.2 bits (82), Expect = 0.080
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 435 KVAELAHANRRVEQHEA---EVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ 491
KV L R+ E+ +A E++K + R ++ + EL EL++ H+Q + + L EQ
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK----ELEQKHSQLTEEKNLLQEQ 902
Query: 492 TEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQ 548
+ L + E ++ RL ++Q AR EE ED L + Q
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL--EEEEDRGQQLQAERKKMAQ 957
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 115 bits (288), Expect = 1e-25
Identities = 116/499 (23%), Positives = 223/499 (44%), Gaps = 71/499 (14%)
Query: 79 ELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAG 138
+L+ R + +EK R++ A + SK ER+RA E R+ + +L + L
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 139 ARRERQEAQGECEARGRELARLRGAR-----GVADQTRDGPEPEAEREPV---------- 183
A ++E + + E+ L ++ V + + E + E +
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 184 -----------------------RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSL 220
RD+ + ++ ++ L E ED + R+L
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 221 GAGGPRGSSGRQERSRLPWEDTAATEEEASK-LTALRLRLDESQKVL------------- 266
A + G + L + EEA K L L+ ++ + Q+ L
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 267 LKEREDKL-ALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSIL---KEAHQDE---- 318
KE E K +L ++ +L+ +L+ + ++ K+E+ ++L+ + A QDE
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 319 ---LGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
+ ++ E+LE+E G +M ++ + + E+L E A E ++ E+ + LER+N
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEK 435
K+LR+++ ++E A+ + + T +AL+ + A L E+ ++ A K K KQ +K
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKI----AQLEEQVEQEAREKQAATKSLKQKDKK 1857
Query: 436 VAELA----HANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ 491
+ E+ + EQ++ + +K RV++LK++L +AE+E + RKLQR LDE
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917
Query: 492 TEQSENLQVQLEHLQSRLR 510
TE +E + ++ L+S+LR
Sbjct: 1918 TESNEAMGREVNALKSKLR 1936
Score = 101 bits (252), Expect = 2e-21
Identities = 121/487 (24%), Positives = 217/487 (44%), Gaps = 65/487 (13%)
Query: 78 RELEEARARAAQMEKTMRRWSDCTANWRE---KWSKVRAERNRARE----------EVRQ 124
R+ EE +A+ +++KT R +E K S++ E+N +E E +
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 125 LRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVR 184
+R RL A +EL E + E E RG++L R + +A Q D E E E R
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER--KKMAQQMLDLEEQLEEEEAAR 973
Query: 185 D-VGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTA 243
+ E+ +++ +E + M +++ + R L +ER + A
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL----------LEERISDLTTNLA 1023
Query: 244 ATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSK 299
EE+A LT L+ + + E + L KE + + L + KLEG+ S + + +L
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 300 TKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWG 359
E+ QL+ +E Q L R L+DE+ +++ +K+ EL G + LQ + +E
Sbjct: 1084 QIAELKMQLAKKEEELQAALAR----LDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1139
Query: 360 RRERLETEKLGLERENKKLRAQVGDL-------EEALARRRRQTA---SALDCDLRASQA 409
R + E +K L E + L+ ++ D +E A+R ++ ALD + R+ +A
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 410 -----------ALFEKNKELADLKHVHGKL---KKQFQEKVAELAHANRRVEQHEAEV-- 453
A+ E ++L K L K+ +++ A+LA R + Q + EV
Sbjct: 1200 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1259
Query: 454 --KKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQT---EQSENLQVQLEHLQSR 508
KKL +V+EL+ + + E E +++ KLQ ++ T ++E ++L +
Sbjct: 1260 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 509 LRRQQQN 515
L Q Q+
Sbjct: 1320 LSSQLQD 1326
Score = 75.1 bits (183), Expect = 2e-13
Identities = 102/470 (21%), Positives = 198/470 (42%), Gaps = 77/470 (16%)
Query: 71 SREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAE-------RNRAREEVR 123
S E+RL++ E++R ++EK R+ +++ E+ + ++A+ + EE++
Sbjct: 1044 SELEVRLKKEEKSRQ---ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Query: 124 QLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPV 183
RLD + A ++ +E +G +L R AR A++ +
Sbjct: 1101 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK------------ 1148
Query: 184 RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTA 243
RD+G E L+++ E ED + S+ Q+ R A
Sbjct: 1149 RDLGEE--------------LEALKTELEDTLD-----------STATQQELR------A 1177
Query: 244 ATEEEASKLTALRLRLDE---SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKT 300
E+E +T L+ LDE S + ++E K A + +E+L +L Q+K L K
Sbjct: 1178 KREQE---VTVLKKALDEETRSHEAQVQEMRQKHA--QAVEELTEQLEQFKRAKANLDKN 1232
Query: 301 KQEMLK-------QLSILKEAHQD---ELGRMSEDLEDELGARSSMDRKMAELRGEMERL 350
KQ + K +L +L +A Q+ + ++ +++ S +R AEL ++ +L
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 351 QAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASA------LDCDL 404
Q E + G E + + L ++ L +Q+ D +E L RQ + L+ +
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ Q L E+ + +L+ L Q + +L VE E K+ + +E L
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 465 KELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQ 514
++ + D+ +LQ+ LD+ +N + + +L+ + R+ Q
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Score = 71.6 bits (174), Expect = 2e-12
Identities = 91/448 (20%), Positives = 190/448 (42%), Gaps = 32/448 (7%)
Query: 96 RWSDCTANWREKWSKVR---AERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEA 152
R SD T N E+ K + +N+ + +L RL K + +++ +G+
Sbjct: 1014 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 153 RGRELARLRGARGVADQTRDGPEPEAEREPVR--DVGSERPPGSQELELVESLLKSMPEE 210
++A L+ E E + R D +++ +++ +E + + E+
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 211 SEDCWEARSLGAGGPRGSSGRQERSRLPWEDT---AATEEEA-----SKLTALRLRLDE- 261
+ AR+ R E + EDT AT++E ++T L+ LDE
Sbjct: 1134 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1193
Query: 262 --SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQ-------LSILK 312
S + ++E K A + +E+L +L Q+K L K KQ + K+ L +L
Sbjct: 1194 TRSHEAQVQEMRQKHAQA--VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1251
Query: 313 EAHQD---ELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKL 369
+A Q+ + ++ +++ S +R AEL ++ +LQ E + G E + +
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 370 GLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLK 429
L ++ L +Q+ D +E L RQ + + LR + +L + L+
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 430 KQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLD 489
+ +L+ + ++++ + V+ L + +KE+ + +E KL+++ +
Sbjct: 1371 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1430
Query: 490 EQTEQSENLQVQLEH---LQSRLRRQQQ 514
++ ++L V L++ L S L ++Q+
Sbjct: 1431 RLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/539 (22%), Positives = 215/539 (39%), Gaps = 101/539 (18%)
Query: 81 EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGAR 140
EE R+ AQ+++ ++ + E+ + + RA+ + + +Q L+ +LAG
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFK----RAKANLDKNKQTLEKENADLAGEL 1247
Query: 141 RERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAE-REPVRDVGSERPPGSQELEL 199
R +A+ E E + ++L + + + DG AE + V + +E
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQ--VQELQSKCSDGERARAELNDKVHKLQNE---------- 1295
Query: 200 VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRLRL 259
VES+ M E+E +A L SS Q+ L E+T ++KL L
Sbjct: 1296 VESVT-GMLNEAEG--KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 260 DESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDEL 319
+ Q L +E E K L R+I L +LS K K ++ + T ++ L K+ Q E+
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST----VEALEEGKKRFQKEI 1408
Query: 320 GRMSEDLEDELGARSSMDRKMAELRGEMERL------QAENAAEWGRRERLETEKLGLER 373
+++ E++ A +++ L+ E++ L Q + + +++R + L E+
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 374 ENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQ 433
A D EA AR + A +L RA + AL K +L+ + LK + +
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKE----ELERTNKMLKAEME 1521
Query: 434 EKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELD---------EAHNQA--- 481
+ V+ + V + E + L ++EE+K +L + EDEL E + QA
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 482 -----------------RKLQRSLDEQTEQSEN-----------------------LQV- 500
R+LQR L E + E+ LQ
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1641
Query: 501 -----------QLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQ 548
QL LQ++++ Q+ R F T + + + E + +Q+Q
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Score = 69.7 bits (169), Expect = 7e-12
Identities = 96/503 (19%), Positives = 206/503 (40%), Gaps = 58/503 (11%)
Query: 68 DWESRE-ELRLRELEEARARAAQ-MEKTMRRWSDCTANWREKWSKVRAER---------- 115
D E+R E +++E+ + A+A + + + + ++ AN + + E
Sbjct: 1191 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1250
Query: 116 NRAREEVRQLRQRLDALTKELAGARRERQEAQGEC-------------------EARGRE 156
+A++EV +++L+A +EL + + A+ E EA G+
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310
Query: 157 LARLRGARGVADQTRDGPEP------------------EAEREPVRDVGSERPPGSQELE 198
+ + ++ Q +D E E ER ++D E Q LE
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370
Query: 199 LVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEAS---KLTAL 255
S L +S+ + + + G++ + T EE+A+ KL
Sbjct: 1371 RHISTLNIQLSDSKK--KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1428
Query: 256 RLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAH 315
+ RL + L+ + +++ L N+EK + + Q + + +S + +
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 316 QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
+ + ++ LE+ L A+ ++R L+ EME L + LE K LE +
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGK--LKKQFQ 433
++++ Q+ +LE+ L + L+ +++A + FE++ + D ++ + L++Q
Sbjct: 1549 EEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLH 1606
Query: 434 EKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTE 493
E EL ++ A KKL +++L+ + A +EA Q RKLQ + +
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1666
Query: 494 QSENLQVQLEHLQSRLRRQQQNA 516
+ E+ + + + + + ++ A
Sbjct: 1667 ELEDARASRDEIFATAKENEKKA 1689
Score = 36.2 bits (82), Expect = 0.080
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 435 KVAELAHANRRVEQHEA---EVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ 491
KV L R+ E+ +A E++K + R ++ + EL EL++ H+Q + + L EQ
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK----ELEQKHSQLTEEKNLLQEQ 902
Query: 492 TEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQ 548
+ L + E ++ RL ++Q AR EE ED L + Q
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL--EEEEDRGQQLQAERKKMAQ 957
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 115 bits (288), Expect = 1e-25
Identities = 116/499 (23%), Positives = 223/499 (44%), Gaps = 71/499 (14%)
Query: 79 ELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAG 138
+L+ R + +EK R++ A + SK ER+RA E R+ + +L + L
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 139 ARRERQEAQGECEARGRELARLRGAR-----GVADQTRDGPEPEAEREPV---------- 183
A ++E + + E+ L ++ V + + E + E +
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 184 -----------------------RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSL 220
RD+ + ++ ++ L E ED + R+L
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 221 GAGGPRGSSGRQERSRLPWEDTAATEEEASK-LTALRLRLDESQKVL------------- 266
A + G + L + EEA K L L+ ++ + Q+ L
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 267 LKEREDKL-ALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSIL---KEAHQDE---- 318
KE E K +L ++ +L+ +L+ + ++ K+E+ ++L+ + A QDE
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 319 ---LGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
+ ++ E+LE+E G +M ++ + + E+L E A E ++ E+ + LER+N
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEK 435
K+LR+++ ++E A+ + + T +AL+ + A L E+ ++ A K K KQ +K
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKI----AQLEEQVEQEAREKQAATKSLKQKDKK 1850
Query: 436 VAELA----HANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ 491
+ E+ + EQ++ + +K RV++LK++L +AE+E + RKLQR LDE
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910
Query: 492 TEQSENLQVQLEHLQSRLR 510
TE +E + ++ L+S+LR
Sbjct: 1911 TESNEAMGREVNALKSKLR 1929
Score = 101 bits (252), Expect = 2e-21
Identities = 121/487 (24%), Positives = 217/487 (44%), Gaps = 65/487 (13%)
Query: 78 RELEEARARAAQMEKTMRRWSDCTANWRE---KWSKVRAERNRARE----------EVRQ 124
R+ EE +A+ +++KT R +E K S++ E+N +E E +
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 125 LRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVR 184
+R RL A +EL E + E E RG++L R + +A Q D E E E R
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER--KKMAQQMLDLEEQLEEEEAAR 966
Query: 185 D-VGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTA 243
+ E+ +++ +E + M +++ + R L +ER + A
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL----------LEERISDLTTNLA 1016
Query: 244 ATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSK 299
EE+A LT L+ + + E + L KE + + L + KLEG+ S + + +L
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 300 TKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWG 359
E+ QL+ +E Q L R L+DE+ +++ +K+ EL G + LQ + +E
Sbjct: 1077 QIAELKMQLAKKEEELQAALAR----LDDEIAQKNNALKKIRELEGHISDLQEDLDSERA 1132
Query: 360 RRERLETEKLGLERENKKLRAQVGDL-------EEALARRRRQTA---SALDCDLRASQA 409
R + E +K L E + L+ ++ D +E A+R ++ ALD + R+ +A
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 410 -----------ALFEKNKELADLKHVHGKL---KKQFQEKVAELAHANRRVEQHEAEV-- 453
A+ E ++L K L K+ +++ A+LA R + Q + EV
Sbjct: 1193 QVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEH 1252
Query: 454 --KKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQT---EQSENLQVQLEHLQSR 508
KKL +V+EL+ + + E E +++ KLQ ++ T ++E ++L +
Sbjct: 1253 KKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 509 LRRQQQN 515
L Q Q+
Sbjct: 1313 LSSQLQD 1319
Score = 75.1 bits (183), Expect = 2e-13
Identities = 102/470 (21%), Positives = 198/470 (42%), Gaps = 77/470 (16%)
Query: 71 SREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAE-------RNRAREEVR 123
S E+RL++ E++R ++EK R+ +++ E+ + ++A+ + EE++
Sbjct: 1037 SELEVRLKKEEKSRQ---ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093
Query: 124 QLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPV 183
RLD + A ++ +E +G +L R AR A++ +
Sbjct: 1094 AALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK------------ 1141
Query: 184 RDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTA 243
RD+G E L+++ E ED + S+ Q+ R A
Sbjct: 1142 RDLGEE--------------LEALKTELEDTLD-----------STATQQELR------A 1170
Query: 244 ATEEEASKLTALRLRLDE---SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKT 300
E+E +T L+ LDE S + ++E K A + +E+L +L Q+K L K
Sbjct: 1171 KREQE---VTVLKKALDEETRSHEAQVQEMRQKHA--QAVEELTEQLEQFKRAKANLDKN 1225
Query: 301 KQEMLK-------QLSILKEAHQD---ELGRMSEDLEDELGARSSMDRKMAELRGEMERL 350
KQ + K +L +L +A Q+ + ++ +++ S +R AEL ++ +L
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 351 QAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASA------LDCDL 404
Q E + G E + + L ++ L +Q+ D +E L RQ + L+ +
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ Q L E+ + +L+ L Q + +L VE E K+ + +E L
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 465 KELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQ 514
++ + D+ +LQ+ LD+ +N + + +L+ + R+ Q
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Score = 71.6 bits (174), Expect = 2e-12
Identities = 91/448 (20%), Positives = 190/448 (42%), Gaps = 32/448 (7%)
Query: 96 RWSDCTANWREKWSKVR---AERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEA 152
R SD T N E+ K + +N+ + +L RL K + +++ +G+
Sbjct: 1007 RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 153 RGRELARLRGARGVADQTRDGPEPEAEREPVR--DVGSERPPGSQELELVESLLKSMPEE 210
++A L+ E E + R D +++ +++ +E + + E+
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 211 SEDCWEARSLGAGGPRGSSGRQERSRLPWEDT---AATEEEA-----SKLTALRLRLDE- 261
+ AR+ R E + EDT AT++E ++T L+ LDE
Sbjct: 1127 LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEE 1186
Query: 262 --SQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQ-------LSILK 312
S + ++E K A + +E+L +L Q+K L K KQ + K+ L +L
Sbjct: 1187 TRSHEAQVQEMRQKHAQA--VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244
Query: 313 EAHQD---ELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKL 369
+A Q+ + ++ +++ S +R AEL ++ +LQ E + G E + +
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 370 GLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLK 429
L ++ L +Q+ D +E L RQ + + LR + +L + L+
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 430 KQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLD 489
+ +L+ + ++++ + V+ L + +KE+ + +E KL+++ +
Sbjct: 1364 RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN 1423
Query: 490 EQTEQSENLQVQLEH---LQSRLRRQQQ 514
++ ++L V L++ L S L ++Q+
Sbjct: 1424 RLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Score = 70.5 bits (171), Expect = 4e-12
Identities = 119/539 (22%), Positives = 215/539 (39%), Gaps = 101/539 (18%)
Query: 81 EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGAR 140
EE R+ AQ+++ ++ + E+ + + RA+ + + +Q L+ +LAG
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFK----RAKANLDKNKQTLEKENADLAGEL 1240
Query: 141 RERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAE-REPVRDVGSERPPGSQELEL 199
R +A+ E E + ++L + + + DG AE + V + +E
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQ--VQELQSKCSDGERARAELNDKVHKLQNE---------- 1288
Query: 200 VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRLRL 259
VES+ M E+E +A L SS Q+ L E+T ++KL L
Sbjct: 1289 VESVT-GMLNEAEG--KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 260 DESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDEL 319
+ Q L +E E K L R+I L +LS K K ++ + T ++ L K+ Q E+
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST----VEALEEGKKRFQKEI 1401
Query: 320 GRMSEDLEDELGARSSMDRKMAELRGEMERL------QAENAAEWGRRERLETEKLGLER 373
+++ E++ A +++ L+ E++ L Q + + +++R + L E+
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 374 ENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQ 433
A D EA AR + A +L RA + AL K +L+ + LK + +
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKE----ELERTNKMLKAEME 1514
Query: 434 EKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELD---------EAHNQA--- 481
+ V+ + V + E + L ++EE+K +L + EDEL E + QA
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 482 -----------------RKLQRSLDEQTEQSEN-----------------------LQV- 500
R+LQR L E + E+ LQ
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD 1634
Query: 501 -----------QLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQ 548
QL LQ++++ Q+ R F T + + + E + +Q+Q
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Score = 69.7 bits (169), Expect = 7e-12
Identities = 96/503 (19%), Positives = 206/503 (40%), Gaps = 58/503 (11%)
Query: 68 DWESRE-ELRLRELEEARARAAQ-MEKTMRRWSDCTANWREKWSKVRAER---------- 115
D E+R E +++E+ + A+A + + + + ++ AN + + E
Sbjct: 1184 DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVL 1243
Query: 116 NRAREEVRQLRQRLDALTKELAGARRERQEAQGEC-------------------EARGRE 156
+A++EV +++L+A +EL + + A+ E EA G+
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303
Query: 157 LARLRGARGVADQTRDGPEP------------------EAEREPVRDVGSERPPGSQELE 198
+ + ++ Q +D E E ER ++D E Q LE
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363
Query: 199 LVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEAS---KLTAL 255
S L +S+ + + + G++ + T EE+A+ KL
Sbjct: 1364 RHISTLNIQLSDSKK--KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKT 1421
Query: 256 RLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAH 315
+ RL + L+ + +++ L N+EK + + Q + + +S + +
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 316 QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLEREN 375
+ + ++ LE+ L A+ ++R L+ EME L + LE K LE +
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 376 KKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGK--LKKQFQ 433
++++ Q+ +LE+ L + L+ +++A + FE++ + D ++ + L++Q
Sbjct: 1542 EEMKTQLEELEDEL-QATEDAKLRLEVNMQALKGQ-FERDLQARDEQNEEKRRQLQRQLH 1599
Query: 434 EKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTE 493
E EL ++ A KKL +++L+ + A +EA Q RKLQ + +
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQR 1659
Query: 494 QSENLQVQLEHLQSRLRRQQQNA 516
+ E+ + + + + + ++ A
Sbjct: 1660 ELEDARASRDEIFATAKENEKKA 1682
Score = 36.2 bits (82), Expect = 0.080
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 9/117 (7%)
Query: 435 KVAELAHANRRVEQHEA---EVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ 491
KV L R+ E+ +A E++K + R ++ + EL EL++ H+Q + + L EQ
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK----ELEQKHSQLTEEKNLLQEQ 895
Query: 492 TEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQ 548
+ L + E ++ RL ++Q AR EE ED L + Q
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL--EEEEDRGQQLQAERKKMAQ 950
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 115 bits (288), Expect = 1e-25
Identities = 109/489 (22%), Positives = 228/489 (46%), Gaps = 46/489 (9%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRL 129
E R +L E E+ + R+ ++E+ + A + + ++ + +A+E +++ +
Sbjct: 821 EMRVKLLQEENEKLQGRSEELERRV-------AQLQRQIEDLKGDEAKAKETLKKYEGEI 873
Query: 130 DALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDG-----PEPEAEREPVR 184
L + L AR+E +EA A EL +G Q + E ++E +R
Sbjct: 874 RQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLR 933
Query: 185 DVGSERPPGSQEL-ELVESLLKSMPE--ESEDCWEARSLGAGGPRGSSGRQERSRLPWED 241
+ +E L + +E L K M + E+ R+E + + +
Sbjct: 934 RLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQL 993
Query: 242 TAAT-EEEASKLTALRL----RLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEE 296
T E E S+LTA+++ RL E + + +D+ R + LE L + + E
Sbjct: 994 KEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQL--LEQTLKDLEYELEA 1051
Query: 297 LSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAA 356
S K + S L + +D++ ++ +LE+E + +++ R +ME+L+ E
Sbjct: 1052 KSHLKDDR----SRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQ 1107
Query: 357 EWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNK 416
E R+ LE +K+ LER+NK L++++ LE + + ++ + + L + +
Sbjct: 1108 ERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEER 1167
Query: 417 ELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDE 476
+ A+L+ + +L+++ +E V ++ + + + +L LR++ +K+++ +AE+E+D
Sbjct: 1168 DRANLQLSNRRLERKVKELVMQVDDEHLSLTDQK---DQLSLRLKAMKRQVEEAEEEIDR 1224
Query: 477 AHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGT 536
+ +KLQR L+EQ + +E+LQ QL ++ LR ++ + +
Sbjct: 1225 LESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVL----------------- 1267
Query: 537 SDLDEDEDL 545
D+D+D+DL
Sbjct: 1268 DDMDDDDDL 1276
Score = 75.5 bits (184), Expect = 1e-13
Identities = 109/448 (24%), Positives = 188/448 (41%), Gaps = 112/448 (25%)
Query: 111 VRAERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQT 170
++ ER R R + +LR + + +E + ++ +E++GE EL +++
Sbjct: 640 IKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVK--------- 690
Query: 171 RDGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSG 230
E E + +RD+ + EL+ + SED
Sbjct: 691 ---MEREQHQTEIRDLQDQLSEMHDELD--------SAKRSED----------------- 722
Query: 231 RQERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQW 290
+E+ L E A ++ L A E Q+ LL++RE R + L+G L
Sbjct: 723 -REKGALIEELLQAKQDLQDLLIA-----KEEQEDLLRKRE------RELTALKGALK-- 768
Query: 291 KIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDE------LGARSS---MDRKMA 341
EE+S QEM K LKE + EL + E +E+ L +RS+ D+
Sbjct: 769 ----EEVSSHDQEMDK----LKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGT 820
Query: 342 ELRGEMERLQAENAAEWGRRERLETEKLGLERE--------------NKKLRAQVGDLEE 387
E+R ++ LQ EN GR E LE L+R+ KK ++ LEE
Sbjct: 821 EMR--VKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEE 878
Query: 388 ALARRRRQ------TASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAH 441
AL R++ AL+ +L A+Q L + +E K + KLK++ ++K
Sbjct: 879 ALVHARKEEKEAVSARRALENELEAAQGNLSQTTQE---QKQLSEKLKEESEQK----EQ 931
Query: 442 ANRRVEQHEAEVKKLRLRVEELKKELA-----------QAEDELDEAHNQARK----LQR 486
R + E E L +E+L+KE+A + +++LDE + R+ +QR
Sbjct: 932 LRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQR 991
Query: 487 SLDEQTEQSENLQVQLEHLQSRLRRQQQ 514
L E+T ++E ++ +Q +R ++
Sbjct: 992 QLKEKTLEAEKSRLTAMKMQDEMRLMEE 1019
Score = 73.2 bits (178), Expect = 6e-13
Identities = 113/512 (22%), Positives = 208/512 (40%), Gaps = 88/512 (17%)
Query: 73 EELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDAL 132
EELR + E+ + ++ + N E + +V+ ER + + E+R L+ +L +
Sbjct: 652 EELRSQHNEKVEENSTLQQRLEESEGELRKNLEELF-QVKMEREQHQTEIRDLQDQLSEM 710
Query: 133 TKELAGARRE-------------------------RQEAQGECEARGRELARLRGAR--- 164
EL A+R ++E + R REL L+GA
Sbjct: 711 HDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEE 770
Query: 165 -GVADQTRD------GPEPEAEREPVRD-------VGSERPPGSQELELVESLLKSMPEE 210
DQ D E +A RE V + + S Q+ E +K + EE
Sbjct: 771 VSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEE 830
Query: 211 SEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLKER 270
+E + + R + Q + D A +E K +L+E+ KE
Sbjct: 831 NE---KLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEE 887
Query: 271 ED----KLALSRNIEKLEGELSQWKIKYEELS---KTKQEMLKQLSILKEAHQDE---LG 320
++ + AL +E +G LSQ + ++LS K + E +QL LK ++E LG
Sbjct: 888 KEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLG 947
Query: 321 RMSEDLEDELGARSSMDR-KMAELRGEMERLQAENAAEWGRRER------LETEK----- 368
+ E L+ E+ R EL+ +++ + +N E +R LE EK
Sbjct: 948 KTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTA 1007
Query: 369 LGLERENKKLRAQVGDL----EEALARRR--RQTASALDCDLRASQAALFEKNKELADLK 422
+ ++ E + + ++ D +EAL +R+ QT L+ +L A + LK
Sbjct: 1008 MKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAK-----------SHLK 1056
Query: 423 HVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQAR 482
+L KQ ++KV++L +E+ L R+ ++++ Q +EL + +
Sbjct: 1057 DDRSRLVKQMEDKVSQL---EMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQ 1113
Query: 483 KLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQ 514
L+ Q+++L+ ++ HL+ R ++
Sbjct: 1114 DLECDKISLERQNKDLKSRIIHLEGSYRSSKE 1145
Score = 56.2 bits (134), Expect = 7e-08
Identities = 67/296 (22%), Positives = 130/296 (43%), Gaps = 32/296 (10%)
Query: 247 EEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLK 306
E+ SKLT + + E Q+ L E +N + ++ E + + EEL E ++
Sbjct: 614 EQKSKLT---IEVAELQRQLQLE-------VKNQQNIKEERERMRANLEELRSQHNEKVE 663
Query: 307 QLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLET 366
+ S L++ ++ G + ++LE+ + ++ E+R ++L + L++
Sbjct: 664 ENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSE-------MHDELDS 716
Query: 367 EKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHG 426
K +RE L +EE L + +Q L + L ++ +EL LK G
Sbjct: 717 AKRSEDREKGAL------IEELL--QAKQDLQDLLIAKEEQEDLLRKRERELTALK---G 765
Query: 427 KLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQR 486
LK++ E+ ++ EQ++AE++ LR VEE K + + + +
Sbjct: 766 ALKEEVSSHDQEM---DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEM 822
Query: 487 SLDEQTEQSENLQVQLEHLQSRLRR-QQQNAPLFGKIRSARFGTEEAEDGTSDLDE 541
+ E++E LQ + E L+ R+ + Q+Q L G A+ ++ E L+E
Sbjct: 823 RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEE 878
Score = 44.3 bits (103), Expect = 3e-04
Identities = 41/156 (26%), Positives = 74/156 (47%), Gaps = 16/156 (10%)
Query: 374 ENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQ 433
E K L Q L +A +RQ L +++ Q E+ + A+L+ +L+ Q
Sbjct: 608 EVKDLLEQKSKLTIEVAELQRQ----LQLEVKNQQNIKEERERMRANLE----ELRSQHN 659
Query: 434 EKVAELAHANRRVEQHEAEVKK-------LRLRVEELKKELAQAEDELDEAHNQARKLQR 486
EKV E + +R+E+ E E++K +++ E+ + E+ +D+L E H++ +R
Sbjct: 660 EKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKR 719
Query: 487 SLD-EQTEQSENLQVQLEHLQSRLRRQQQNAPLFGK 521
S D E+ E L + LQ L +++ L K
Sbjct: 720 SEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK 755
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 105 bits (261), Expect = 1e-22
Identities = 103/487 (21%), Positives = 231/487 (47%), Gaps = 43/487 (8%)
Query: 78 RELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELA 137
R LEEA + A++E+ +++ R + + + ++ + V +L + AL +++
Sbjct: 1483 RALEEAMEQKAELERLNKQF-------RTEMEDLMSSKDDVGKSVHELEKSKRALEQQVE 1535
Query: 138 GARRERQEAQGECEA----RGRELARLRGARGVADQTRDGPEPEAEREP------VRDVG 187
+ + +E + E +A + R L+ + ++ G + ++E + VR++
Sbjct: 1536 EMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME 1595
Query: 188 SERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERS--------RLPW 239
+E ++ + + K + + +D EA A R + +Q R
Sbjct: 1596 AELEDERKQRSMAVAARKKLEMDLKDL-EAHIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELS- 298
+DT A+ EE + + E++K L + + L + E Q + + +EL+
Sbjct: 1655 DDTRASREE------ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD 1708
Query: 299 KTKQEMLKQLSILKEAHQDE--LGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAA 356
+ K L+E + E + ++ E+LE+E G ++ ++ + +++++ +
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNL 1768
Query: 357 EWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNK 416
E ++ E + LER+NK+L+ ++ ++E + + + + +AL+ + + L + K
Sbjct: 1769 ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828
Query: 417 EL-ADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELD 475
E A K V + +K+ ++ + ++ R EQ++ + K R+++LK++L +AE+E
Sbjct: 1829 ERQAACKQVR-RTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQ 1887
Query: 476 EAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSAR----FGTEE 531
A+ RKLQR L++ TE ++ + ++ L+++LRR + P R AR G++E
Sbjct: 1888 RANASRRKLQRELEDATETADAMNREVSSLKNKLRR--GDLPFVVPRRMARKGAGDGSDE 1945
Query: 532 AEDGTSD 538
DG +D
Sbjct: 1946 EVDGKAD 1952
Score = 88.2 bits (217), Expect = 2e-17
Identities = 105/484 (21%), Positives = 216/484 (44%), Gaps = 57/484 (11%)
Query: 70 ESREELR--LRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQ 127
+ EEL+ L +EE A+ K +R + +E RA RN+A ++ R L +
Sbjct: 1080 KKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGE 1139
Query: 128 RLDALTKEL------AGARRE------------RQEAQGECEARGRELARLR-----GAR 164
L+AL EL A++E ++ + E + ++ +R
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 165 GVADQTRDGPEPEAEREPVRD-VGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAG 223
+A+Q +A E + + +ER + E++++ K E EA+ L
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ-GKGDSEHKRKKVEAQ-LQEL 1257
Query: 224 GPRGSSGRQERSRLPWEDT-------------AATEEEASKLT----ALRLRLDESQKVL 266
+ + G + R+ L + T + ++ ++SKLT AL +L ++Q++L
Sbjct: 1258 QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELL 1317
Query: 267 LKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDL 326
+E KL+LS ++++E E + ++ + EE + K + KQ++ L ++ M + +
Sbjct: 1318 QEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL----HAQVADMKKKM 1373
Query: 327 EDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLE 386
ED +G + + +L+ ++E L + + ++LE K L++E L + D +
Sbjct: 1374 EDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL-DHQ 1432
Query: 387 EALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRV 446
A + D L A + + K E D + K + K LA A
Sbjct: 1433 RQSACNLEKKQKKFD-QLLAEEKTISAKYAEERDRAEAEAREK---ETKALSLARALEEA 1488
Query: 447 EQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQ 506
+ +AE+++L + ++L ++D++ ++ ++ K +R+L++Q E+ ++ QLE L+
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE---MKTQLEELE 1545
Query: 507 SRLR 510
L+
Sbjct: 1546 DELQ 1549
Score = 80.5 bits (197), Expect = 4e-15
Identities = 99/460 (21%), Positives = 206/460 (44%), Gaps = 47/460 (10%)
Query: 80 LEEARARAAQMEKTMR-RWSDCTANWREKWSKVRAE---RNRAREEVRQLRQRLDALTKE 135
LE+ + A+ +K + R ++ T N E+ K ++ +N+ + L +RL K+
Sbjct: 983 LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ 1042
Query: 136 LAGARRERQEAQGECEARGRELARLRG--ARGVADQTRDGPEPEAEREPVRDVGSERPPG 193
+ R++ +G+ ++A L+ A + E +A V + +++
Sbjct: 1043 RQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMA 1102
Query: 194 SQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDT----AATEEEA 249
+++ +ES + + E+ E +R+ R E + EDT AA +E
Sbjct: 1103 LKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELR 1162
Query: 250 SK----LTALRLRLDESQKVLLKE-REDKLALSRNIEKLEGELSQWKIKYEELSKTKQEM 304
SK + L+ L+E K + +E + S+ +E+L +L Q K L K KQ +
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222
Query: 305 LKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERL 364
++E G ++ +++ L + + K ++ +++ LQ + + ER+
Sbjct: 1223 -----------ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK----FNEGERV 1267
Query: 365 ETEKLGLERENKKLRAQVGDLEEALARRRRQTA------SALDCDLRASQAALFEKNKEL 418
TE L + KL+ ++ ++ L++ +++ SAL+ L+ +Q L E+N++
Sbjct: 1268 RTE---LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 419 ADL----KHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDEL 474
L K V + K F+E++ E A +E+ ++ L +V ++KK++ + L
Sbjct: 1325 LSLSTKLKQVEDE-KNSFREQLEEEEEAKHNLEK---QIATLHAQVADMKKKMEDSVGCL 1380
Query: 475 DEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQ 514
+ A RKLQ+ L+ +++ E + L+ R QQ
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQ 1420
Score = 73.9 bits (180), Expect = 3e-13
Identities = 65/303 (21%), Positives = 129/303 (42%), Gaps = 29/303 (9%)
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELS- 298
E A E +++ L+ +L + L ++ + + L E+L L+ K + EE+
Sbjct: 859 EKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICH 918
Query: 299 ------KTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQA 352
+ ++E + L K+ Q + + E LE+E AR + + ++++L+
Sbjct: 919 DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEE 978
Query: 353 ENAAEWGRRERLETEKLGLE---------------------RENKKLRAQVGDLEEALAR 391
E + +L EK LE + K A + DLEE L R
Sbjct: 979 EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRR 1038
Query: 392 RRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEA 451
+Q L+ R + + + ++A+L+ +LK Q +K EL A RVE+ A
Sbjct: 1039 EEKQRQE-LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAA 1097
Query: 452 EVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRR 511
+ ++ EL+ ++++ +++L+ K ++ + E+ E L+ +LE
Sbjct: 1098 QKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAA 1157
Query: 512 QQQ 514
QQ+
Sbjct: 1158 QQE 1160
Score = 70.5 bits (171), Expect = 4e-12
Identities = 76/303 (25%), Positives = 141/303 (46%), Gaps = 40/303 (13%)
Query: 232 QERSRLPWEDTAATEEEASKLTALRLRLDE---SQKVLLKERE--------DKLALSRNI 280
QE+ + E A EE ++LTA + L+E + ++E E +K + +NI
Sbjct: 886 QEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI 945
Query: 281 EKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKM 340
++LE +L + EE ++ K ++ K + EA +L LED+ + + ++K+
Sbjct: 946 QELEEQLEE-----EESARQKLQLEK---VTTEAKLKKLEEEQIILEDQ-NCKLAKEKKL 996
Query: 341 AELRGEMERLQAENAAEWGRRERLETEK-LGLERENKKLRAQVGDLEEALARRRRQTASA 399
E + AE+ E EK L + K A + DLEE L R +Q
Sbjct: 997 LE----------DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQ-RQE 1045
Query: 400 LDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLR 459
L+ R + + + ++A+L+ +LK Q +K EL A RVE+ A+ +
Sbjct: 1046 LEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKK 1105
Query: 460 VEELKKELAQAEDELDE---AHNQARKLQRSLDEQ-----TEQSENLQVQLEHLQSRLRR 511
+ EL+ ++++ +++L+ + N+A K +R L E+ TE + L + R +R
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 512 QQQ 514
+Q+
Sbjct: 1166 EQE 1168
Score = 67.8 bits (164), Expect = 2e-11
Identities = 94/473 (19%), Positives = 198/473 (41%), Gaps = 54/473 (11%)
Query: 79 ELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAG 138
++ E +A+ A+++ + + + + + A++N A +++R+L ++ L ++L
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 139 ARRERQEAQGECEARGRELARLRGA-RGVADQTRDGPEPEAEREPVRDVGSERPPGSQEL 197
R R +A+ + G EL L+ D T E ++RE ++V + +E
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE--QEVNILKKTLEEEA 1180
Query: 198 ELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRL 257
+ E+ ++ M ++ E + E+ A E+ L R
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELA-------------EQLEQTKRVKANLEKAKQTLENERG 1227
Query: 258 RLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQD 317
L KVLL+ + D +K+E +L + ++K+ E + + E+ +++ L+ +
Sbjct: 1228 ELANEVKVLLQGKGDS---EHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDN 1284
Query: 318 ELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKK 377
G +S+ ++L+ E LQ EN ++ L T+ +E E
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR----QKLSLSTKLKQVEDEKNS 1340
Query: 378 LRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVA 437
R Q+ + EEA +Q A+ L A A + +K ++ ++K++ Q+ +
Sbjct: 1341 FREQLEEEEEAKHNLEKQIAT-----LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395
Query: 438 ELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSEN 497
L+ ++HE +V ++L+K + + ELD+ L LD Q + + N
Sbjct: 1396 GLS------QRHEEKVAAY----DKLEKTKTRLQQELDD-------LLVDLDHQRQSACN 1438
Query: 498 LQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQVA 550
L+ + + L + K SA++ EE + ++ E E + +A
Sbjct: 1439 LEKKQKKFDQLLAEE--------KTISAKY-AEERDRAEAEAREKETKALSLA 1482
Score = 52.8 bits (125), Expect = 8e-07
Identities = 62/307 (20%), Positives = 129/307 (42%), Gaps = 37/307 (12%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRL 129
+S + R +++ R AQM+ MR D A+ E + A+ ++++ + +
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREE----ILAQAKENEKKLKSMEAEM 1682
Query: 130 DALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVGSE 189
L +ELA A R +++AQ E + E+A G +A + + E + + E
Sbjct: 1683 IQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR-----IAQLEEE 1737
Query: 190 RPPGSQELELVESLLKSMPEESEDCWEARSL-GAGGPRGSSGRQERSR---------LPW 239
EL+ LK + + +L + + + RQ+ R
Sbjct: 1738 LEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEM 1797
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKI------- 292
E T ++ +AS +TAL ++ + ++ L E +++ A + + + E +L +
Sbjct: 1798 EGTVKSKYKAS-ITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERR 1856
Query: 293 ---KYEELSKTKQEMLKQLSILKEAHQDELGR-------MSEDLEDELGARSSMDRKMAE 342
+Y++ + LKQL E ++E R + +LED +M+R+++
Sbjct: 1857 NAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Query: 343 LRGEMER 349
L+ ++ R
Sbjct: 1917 LKNKLRR 1923
Score = 30.8 bits (68), Expect = 3.4
Identities = 36/183 (19%), Positives = 76/183 (41%), Gaps = 27/183 (14%)
Query: 381 QVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKV---- 436
QV EE + + + +R Q A + E+ L+ K Q QE++
Sbjct: 839 QVSRQEEEMMAKEEELVK-----VREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET 893
Query: 437 ---AELAHANRRVEQHEAEVKK----LRLRVEELKKELAQAEDELDEAHNQARKLQRSLD 489
AE R+ + E+++ L RVEE ++ + E + ++L+ L+
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 490 EQTEQSENLQVQLEHLQSRLRR--------QQQNAPLFGKIRSARFGTEEAEDGTSDLDE 541
E+ + LQ++ +++L++ + QN L + + + + T++L E
Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKL---AKEKKLLEDRIAEFTTNLTE 1010
Query: 542 DED 544
+E+
Sbjct: 1011 EEE 1013
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 104 bits (259), Expect = 2e-22
Identities = 124/510 (24%), Positives = 225/510 (44%), Gaps = 61/510 (11%)
Query: 70 ESREELRLRELEEARA-----RAAQMEKTMRRWSDCTANWREKWSKVRAERNRAR----- 119
+ E + + + EA A R A +E T+R + +R + + + R
Sbjct: 696 DCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDG 755
Query: 120 -----EEVRQLRQRLDALTKELAGARRERQEAQGECEARGREL-ARLRGA-RGVADQTRD 172
+R QRL+A ++L A QE +G A R L ARL A RG+A R
Sbjct: 756 GEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLA---RL 812
Query: 173 GPEPEAEREPVRDVGSERPP---GSQELE--------LVESLLKSMPEESEDCWEARSLG 221
G E + + + G +R G ELE V+ L K + + ED +A
Sbjct: 813 GQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQL 872
Query: 222 AGGPRGSSGRQER----SRLPWEDTAATEEEAS--------KLTALRLRLDESQKVLLKE 269
+ R ++ +D A+ E+ S ++ LR L SQ
Sbjct: 873 QAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTA 932
Query: 270 REDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDE 329
R DK L++ ++ LE E E +++ + +QL L+E ++ R+ +L++E
Sbjct: 933 RLDKELLAQRLQGLEQEA-------ENKKRSQDDRARQLKGLEE----KVSRLETELDEE 981
Query: 330 LGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEAL 389
+ ++ R ++++L+ E E R+ LE +K+ LER+NK L+ ++ E
Sbjct: 982 KNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGF- 1040
Query: 390 ARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQH 449
++ + S L+ + Q L + +E L+ + KL++ KV EL+ QH
Sbjct: 1041 -QKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLER----KVKELSIQIEDERQH 1095
Query: 450 EAEVK-KLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR 508
+ K +L LRV+ LK+++ +AE+E++ +K QR ++EQ E +E LQ +++ L+
Sbjct: 1096 VNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKSLEKD 1155
Query: 509 LRRQQQNAPLFGKIRSARFGTEEAEDGTSD 538
R+ + +++ ++E D D
Sbjct: 1156 SWRKASRSAAESALKNEGLSSDEEFDSVYD 1185
Score = 70.9 bits (172), Expect = 3e-12
Identities = 113/505 (22%), Positives = 212/505 (41%), Gaps = 57/505 (11%)
Query: 63 LLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEV 122
+L +G ES +R R++ + + + A E KV + + EEV
Sbjct: 321 ILREGSSESETSVR-RKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEV 379
Query: 123 RQ----------LRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRD 172
++ L ++L+ T+E + + + +GE + +EL ++ + R
Sbjct: 380 KKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRH 439
Query: 173 GPEPEAEREPVRDVGSERPPGSQEL---------ELVESLLKSMPEESEDCWEARSLGAG 223
G E + + + P ++E+ EL+E +L+ + E+ R
Sbjct: 440 GLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGK-QRVEEQLRLRERELT 498
Query: 224 GPRGSSGRQERSRLPWEDTAATEEEASKLTALRLRLDESQK--VLLKEREDKLAL----S 277
+G+ + SR + + + R D +Q VL ER+ AL
Sbjct: 499 ALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQ 558
Query: 278 RNIEKLEGELSQWKIKY----EELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELG-A 332
R +E+ E W+ + E+L TKQE+L QL + KE ++ELG E L+ EL A
Sbjct: 559 RELEETSEETGHWQSMFQKNKEDLRATKQELL-QLRMEKEEMEEELGEKIEVLQRELEQA 617
Query: 333 RSS---------MDRKMAELRGEMERLQAENAAEW--GRRERLETEK----LGLEREN-K 376
R+S + +++ + E++ LQAE ++ GR E EK L +E + +
Sbjct: 618 RASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGR 677
Query: 377 KLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKV 436
+L Q L++ L + R+ DC+ AS+A + + E L ++ +E
Sbjct: 678 ELEEQNLQLQKTLQQLRQ------DCE-EASKAKMVAE-AEATVLGQRRAAVETTLRETQ 729
Query: 437 AELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSE 496
E RR+ E ++K+ R V+ + A+ D+L + ++L+ +L+ E+
Sbjct: 730 EENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEG 789
Query: 497 NLQVQLEHLQSRLRRQQQNAPLFGK 521
+L L++RL Q+ G+
Sbjct: 790 SLAAAKRALEARLEEAQRGLARLGQ 814
Score = 62.8 bits (151), Expect = 8e-10
Identities = 78/360 (21%), Positives = 155/360 (43%), Gaps = 39/360 (10%)
Query: 205 KSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRLRLDESQK 264
KS P+ D EA P GS + + ++E E S + L L++ Q
Sbjct: 293 KSTPDLLRDQQEA------APPGSVDHMKATIYGILREGSSESETSVRRKVSLVLEKMQP 346
Query: 265 VLLKEREDKLA------LSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDE 318
+++ A L+R +E+L+ +L + K ++L ++ + +QL E +E
Sbjct: 347 LVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQL----EEKTEE 402
Query: 319 LGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKL 378
R+ E LE G ++++ ++ ++ Q E+ R LET+ + L+ + K +
Sbjct: 403 CSRLQELLERRKGEAQQSNKELQNMKRLLD--QGEDL-----RHGLETQVMELQNKLKHV 455
Query: 379 RAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAE 438
+ +E L + +T L+ L Q + +L + G LK++ + E
Sbjct: 456 QGPE-PAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQE 514
Query: 439 LAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENL 498
+ H +Q++ + ++LR +++ ++ A E E + R LQR L+E +E++ +
Sbjct: 515 VEHVR---QQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHW 571
Query: 499 Q------------VQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQ 546
Q + E LQ R+ +++ L KI + E+A D + E L+
Sbjct: 572 QSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLK 631
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 97.8 bits (242), Expect = 2e-20
Identities = 114/497 (22%), Positives = 211/497 (42%), Gaps = 55/497 (11%)
Query: 86 RAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGARRERQE 145
++A+ EK M + +++ +K A+R E++ L Q + L ++ +
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 146 AQGECEARGRELARLRGA-RGVADQTRDGPEPEAE----REPVRDVGSERPPGSQELELV 200
A+ C+ + +L + V ++ D E AE + + D SE +LEL
Sbjct: 902 AEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 961
Query: 201 -----------ESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEA 249
E+ +K++ EE E A R QE + +D A E++
Sbjct: 962 LAKVEKEKHATENKVKNLTEELSGLDETI---AKLTREKKALQEAHQQALDDLQAEEDKV 1018
Query: 250 SKLTALRLRLDES----QKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEML 305
+ L + +L++ + L +E++ ++ L RN KLEG+L + +L KQ++
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078
Query: 306 KQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLE 365
++L + E ++ +EDE +K+ EL+ +E L+ E AE R + E
Sbjct: 1079 ERL----KKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 366 TEKLGLERENKKLRAQVGDLEEA---------LARRRRQTASALDCDLRASQAALFEKNK 416
++ RE ++L + LEEA L ++R L DL + A +
Sbjct: 1135 KQRSDYARELEELSER---LEEAGGVTSTQIELNKKREAEFLKLRRDL---EEATLQHEA 1188
Query: 417 ELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVK----KLRLRVEELKKELAQAE- 471
+A L+ H + E++ L +++E+ ++E K L +E + K A E
Sbjct: 1189 MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248
Query: 472 ------DELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSA 525
D+L EA + ++QRSL E T Q LQ + L +L ++ RS
Sbjct: 1249 ICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS--RSK 1306
Query: 526 RFGTEEAEDGTSDLDED 542
+ T++ E+ L+E+
Sbjct: 1307 QAFTQQTEELKRQLEEE 1323
Score = 84.7 bits (208), Expect = 2e-16
Identities = 101/518 (19%), Positives = 209/518 (40%), Gaps = 78/518 (15%)
Query: 78 RELEEARARAAQMEKTMRR-WSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKEL 136
R+LEEA + M +R+ +D A E+ ++ + + +E + + +D L+ +
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236
Query: 137 AGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVGSERPPGSQE 196
+ + + C +L+ RG ++ + R + +E S++
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR-----LQTEAGELSRQ 1291
Query: 197 LELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALR 256
LE ES++ + + + +E R E+ A A L + R
Sbjct: 1292 LEEKESIVSQLSRSKQAFTQQT-------------EELKRQLEEENKAKNALAHALQSSR 1338
Query: 257 LRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKY--------EELSKTKQEMLKQ- 307
D ++ +E+E K L R + K E++QW+ KY EEL + K+++ ++
Sbjct: 1339 HDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1398
Query: 308 ----------------LSILKEAHQDELGRMSEDLEDELGARSSMDRK-------MAELR 344
L K+ Q E+ + D+E +++D+K +AE +
Sbjct: 1399 QDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWK 1458
Query: 345 GEMERLQAENAAEWGRRERLETEKLGL--------------ERENKKLRAQVGDLEEALA 390
+ E QAE A L TE L +RENK L ++ DL E +A
Sbjct: 1459 TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIA 1518
Query: 391 RRRR------QTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANR 444
+ ++ ++ + Q AL E A L+H K+ + E + +R
Sbjct: 1519 ENGKTIHELEKSRKQIELEKADIQLALEEAE---AALEHEEAKILRIQLELTQVKSEIDR 1575
Query: 445 RVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEH 504
++ + + E+++L+ + + + A D + N+A +L++ ++ + +++QL H
Sbjct: 1576 KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNE---IEIQLSH 1632
Query: 505 LQSRLRRQQQN-APLFGKIRSARFGTEEAEDGTSDLDE 541
+ ++ + G+++ + ++A G DL E
Sbjct: 1633 ANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKE 1670
Score = 70.1 bits (170), Expect = 5e-12
Identities = 114/507 (22%), Positives = 217/507 (42%), Gaps = 73/507 (14%)
Query: 74 ELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ-LRQRL--- 129
+L + EE + A++++ + + + A WR K+ +R EE ++ L QRL
Sbjct: 1342 DLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDS 1401
Query: 130 ----DALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP-------EA 178
+A+ + A + +Q QGE E ++ R D+ + + +
Sbjct: 1402 EEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC 1461
Query: 179 EREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLP 238
E S + S EL + LK+ EE+ D E + ++E L
Sbjct: 1462 EESQAELEASLKESRSLSTELFK--LKNAYEEALDQLE------------TVKRENKNLE 1507
Query: 239 WEDTAATEEEASKLTALRLRLDESQKVLLKERED-KLALSR----------NIEKLEGEL 287
E TE+ A + L++S+K + E+ D +LAL I +++ EL
Sbjct: 1508 QEIADLTEQIAENGKTIH-ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLEL 1566
Query: 288 SQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEM 347
+Q K + + K E ++QL K +Q + M L+ E+ +R+ R ++ G++
Sbjct: 1567 TQVKSEIDRKIAEKDEEIEQL---KRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDL 1623
Query: 348 ERLQAE------NAAEWGRRER-----LETEKLGLERENKKLRAQVGDLEEALARRRRQT 396
++ + AAE + R L+ +L L+ LR Q DL+E LA R+
Sbjct: 1624 NEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLD---DALRGQE-DLKEQLAIVERR- 1678
Query: 397 ASALDCDLRASQAAL--FEKNKELADLKHVHGKLKKQF-QEKVAELAHANRRVEQHEAEV 453
A+ L ++ +A L E+ ++LA+ + + + Q + L H +++E ++
Sbjct: 1679 ANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLE---TDL 1735
Query: 454 KKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQS-------ENLQVQLEHLQ 506
+L+ VE+ ++ AE++ +A A + L ++ + S +NL+ ++ LQ
Sbjct: 1736 MQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQ 1795
Query: 507 SRLRRQQQNAPLFGKIRSARFGTEEAE 533
RL +Q A GK + + T E
Sbjct: 1796 HRLDEAEQLALKGGKKQIQKLETRIRE 1822
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 96.7 bits (239), Expect = 5e-20
Identities = 132/499 (26%), Positives = 225/499 (45%), Gaps = 63/499 (12%)
Query: 71 SREELRLRELEEARARAAQM--EKTMRRWSDCTANWREKWS------KVRAERNRAREEV 122
+ E RLR L E R Q+ E R+ ++ EK + +++ E A +E
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 123 RQLRQRLDALTKELAGARR--ERQEAQGECEARGRELARLRGARG---------VADQTR 171
+RL L ++ A RR E Q AQ + + R LA+LR A V D R
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLR 1918
Query: 172 DGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
+ E E ++ + G ELEL ++S E++ E L A R +
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Query: 232 QERSRLPWED----TAATEEEASK--------LTALRLRLDESQKVLLKEREDKLALSRN 279
+ER R E+ + A EEEA++ + L+ +++E+++ L+ER ++ + +R
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQES-ARQ 2035
Query: 280 IEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRK 339
++ L E +Q +++ EE + K+ + + Q++ + D+L + R+
Sbjct: 2036 LQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------SVLDQLRGEAEAARR 2088
Query: 340 MAELRGEMERLQAENAAEWGRRERLETEKLGLERENK-KLRAQVGDLEEALARRRRQTAS 398
AE E R+QAE A RR+ E E+L E + + RAQ E L + Q A+
Sbjct: 2089 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 399 ALDCDLRASQAALFEKNKELADL-KHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLR 457
+A QAAL +K A++ KH K+F E+ R+ Q E E+ LR
Sbjct: 2148 RR---AQAEQAALRQKQAADAEMEKH------KKFAEQTL------RQKAQVEQELTTLR 2192
Query: 458 LRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEH---LQSRLRRQQQ 514
L++EE + ++EL +A + R + E+ +++VQ+E L++R+ + +
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252
Query: 515 NAPLFGKIRSARFGTEEAE 533
L K + RF EEAE
Sbjct: 2253 ALILRDKDNTQRFLQEEAE 2271
Score = 88.2 bits (217), Expect = 2e-17
Identities = 135/555 (24%), Positives = 239/555 (43%), Gaps = 102/555 (18%)
Query: 74 ELRLRELEEARARAAQME-KTMRRWSDCT-----ANWREKWSKVRAERNRAREEVRQLRQ 127
E RLR+ E RAR Q+ +T +R ++ A++ EK +++ V QLR+
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608
Query: 128 RLDALTKELAGARRERQEAQGECEA---RGRELARLR-------GARGVADQTRDGPEPE 177
+ ++ A A R R+EA+ E E + E RLR + +A + + E
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEAR--------SLGAGGPRGSS 229
AERE R G ++ EL E L+ + +E + R L A +G
Sbjct: 1669 AERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 230 GRQ----ERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLK-----EREDKLALSRNI 280
RQ E +RL E AAT++ +L A ++ +VLL E E + ++
Sbjct: 1728 QRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 281 EKLEGELSQWKIKYEELSKTK---QEMLKQLSIL-------------------------- 311
++LE E +++ EE ++ + +E +Q +
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 312 ------------KEAHQDELGRMSED-------LEDELGA-RSSMDRKMAELR----GEM 347
KEA + L R++ED LE++ ++ ++ ++A+LR E+
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 348 ERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRAS 407
ER + +R ++E E L L+ +K A +LE L R R S + LR+
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR----SNAEDTLRSK 1962
Query: 408 QAALFEKNKE---LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ A E ++ A+ + + +++ Q+ +A A R+ + EV++L+ +VEE +
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022
Query: 465 KELAQAEDE----LDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA-PLF 519
+ +AE E L A A+K R E+ + +Q + + LQ L+++Q L
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQK--RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 520 GKIRSARFGTEEAED 534
G+ +AR EEAE+
Sbjct: 2081 GEAEAARRAAEEAEE 2095
Score = 84.7 bits (208), Expect = 2e-16
Identities = 117/510 (22%), Positives = 212/510 (41%), Gaps = 58/510 (11%)
Query: 62 ALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREE 121
+L A+ + + + L E+E +A+ + + R +A + + +R +A E+
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 122 VRQ--LRQRLDALTKELAGARRERQEAQGECEARGR-----ELARLRGARGVADQTRDGP 174
++Q+ L + L + + +GE EA R E AR++ R A R
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 175 EPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQER 234
E E ++ + R +Q E L K +E+ +A + + E+
Sbjct: 2113 EAERLKQSAEEQAQAR---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169
Query: 235 SRLPWEDTAATEEEASK-LTALRLRLDES--QKVLLKEREDKLAL-----SRNIEKLEGE 286
+ E T + + + LT LRL+L+E+ QK LL E +L +R ++E E
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Query: 287 LSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGE 346
L +++ EELSK K + + L +D R L++E KM ++ E
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF---LQEEA-------EKMKQVAEE 2279
Query: 347 MERLQAENAAEWGRRERLETEKLGLERE--NKKLRAQVGDLEEALARRRRQTASALDCDL 404
RL A E R +L E L +R K L+ ++ ++EA + +L
Sbjct: 2280 AARLSVA-AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
QA +++KE + +L ++ Q L +R + AE ++L+LRV E+
Sbjct: 2339 AQEQARRLQEDKE-----QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393
Query: 465 KELAQAEDELDEAHNQARK-----------------LQRSLDEQTEQS----ENLQVQLE 503
+ A+AE++ QA + L ++L+ Q +QS E L+ +
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453
Query: 504 HLQSRLRRQQQNAPLFGKIRSARFGTEEAE 533
L+ + QQ A L +++S T + E
Sbjct: 2454 ELEREKEKLQQEAKLL-QLKSEEMQTVQQE 2482
Score = 77.0 bits (188), Expect = 4e-14
Identities = 111/459 (24%), Positives = 196/459 (42%), Gaps = 27/459 (5%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANW---REKWSKVRAERNRAREEVRQLR 126
E+ E RLR EE R Q+E T R+ R + + A++ +A+EE +LR
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 127 QRLDALTK-----ELAGARRERQEAQGECEARGRELARLRGARGVADQT-RDGPEPEAER 180
+++ ++ E+ A R + EA+ E + R L L R A++ R + E ER
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVER 1559
Query: 181 EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE---RSRL 237
V E S E EL +S S E++ RSL + R+E R++
Sbjct: 1560 ARQVQVALETAQRSAEAEL-QSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 238 PWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
E A EE +L +L+ +E+ ++ L+ E +A +++ + E E + + + E
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 298 SKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAE 357
+ K E + Q EL + + +L ++ R AE E+ RL+AE
Sbjct: 1675 RRGKAEE-------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQG 1725
Query: 358 WGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKE 417
+R+ LE E L+RE + +LE LA+ R + L RA + + K
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 418 LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEA 477
L+ G+ ++ +E A A Q + + + E ++ LA+ + EA
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845
Query: 478 HNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA 516
+ + +L E+ ++E L+ E + RR ++ A
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Score = 73.6 bits (179), Expect = 5e-13
Identities = 113/498 (22%), Positives = 212/498 (42%), Gaps = 53/498 (10%)
Query: 72 REELR-LREL-EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQL---- 125
R+ELR +E+ E + R + + + RW + A E+W V A+ + + E+ QL
Sbjct: 1150 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1209
Query: 126 ---RQRLDALTKELAGARRERQEAQGECEARGREL-ARLRGARGVADQTRDGPE--PEAE 179
R+ D L L ARR +++ Q A + + +LR + + ++ E E +
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1269
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
R + + + + EL+LV + P S A P+ SG E +
Sbjct: 1270 RFAKQYINAIK---DYELQLVTYKAQLEPVASP---------AKKPKVQSG-SESVIQEY 1316
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIE------KLEGELSQWKIK 293
D E + LT+ ++ S+ + E E++LA + E ++E L + +
Sbjct: 1317 VDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 294 YEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE 353
E ++ K + ++ L++ Q+E+ R E D + S+ ++ +LR E AE
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AE 1432
Query: 354 NAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFE 413
A+ + E E +L +E E + +R Q+ EA R+R + +L+A +A E
Sbjct: 1433 IQAKARQAEAAERSRLRIEEEIRVVRLQL----EATERQR----GGAEGELQALRARAEE 1484
Query: 414 KNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ + +L++Q Q++ ++R Q E E+ E +E +A
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQDE-------SQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 474 LDEAHNQARKLQRSLDE-QTEQSENLQVQLEHLQ--SRLRRQQQNAPLFGKIRSARFGTE 530
L+E QA + +R L + + E++ +QV LE Q + Q + A K +
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 531 EAEDGTSDLDEDEDLQIQ 548
E + L E+ + + Q
Sbjct: 1598 EEHVAVAQLREEAERRAQ 1615
Score = 68.2 bits (165), Expect = 2e-11
Identities = 110/497 (22%), Positives = 217/497 (43%), Gaps = 85/497 (17%)
Query: 73 EELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ-------- 124
E+LR +E E+ AR AQ E+ R EK K + R + +V Q
Sbjct: 2136 EKLR-KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 125 ----------LRQRLDALTKELAGARRERQEAQGEC---EARGRELARLRG---ARGVA- 167
L + L L E A R+R + + E + EL++L+ A A
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 168 -----DQTRDGPEPEAER-EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLG 221
D T+ + EAE+ + V + + +QE + L + ED + R+L
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALA 2308
Query: 222 AGGPRGS-SGRQERSRLPWE-DTAATEEEASKLTALRLRLDESQ-------------KVL 266
+ QE +RL E + ++E ++ A RL+ D+ Q + L
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2368
Query: 267 LKEREDKLALSRNIEKLE---GELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMS 323
ER+ +L +S E+L+ E+S+ + + EE ++ ++ +++ ++ H+ EL
Sbjct: 2369 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHRTEL---- 2422
Query: 324 EDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE--RLETEKLGLERENKKLRAQ 381
++ ++ E++R Q+++ AE R LE EK L++E K L+ +
Sbjct: 2423 ----------ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 382 VGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAH 441
+++ + Q AL + + +L ++ + + K KL++ FQ++VA+
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK---AKLEQLFQDEVAKAQQ 2529
Query: 442 AN----RRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ----TE 493
R+ +Q E E ++L +EE ++ +AE+ + + ++L++ +Q E
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589
Query: 494 QSENLQVQLEHLQSRLR 510
+++ L+ QL+ L+ + R
Sbjct: 2590 ENQRLREQLQLLEEQHR 2606
Score = 63.5 bits (153), Expect = 5e-10
Identities = 122/533 (22%), Positives = 223/533 (41%), Gaps = 76/533 (14%)
Query: 59 PAPALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRA 118
P L+A+ ++ S ++L ++ + AQ E +R C + ++ ++ A R
Sbjct: 948 PEDRLMAEREYGSCSH-HYQQLLQSLEQGAQEESRCQR---CISELKDIRLQLEACETRT 1003
Query: 119 REEVRQLRQRLDAL-TKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPE 177
V +LR LD +E A E+Q+AQ E E G+ +ARL A++ PEP
Sbjct: 1004 ---VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPS 1057
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRL 237
+R ELEL L+ + S E + RG+ G +E R
Sbjct: 1058 PAAPTLR----------SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107
Query: 238 PWED--------TAATEEEASKLTALRLRLD-ESQKVLLKEREDKLALSRNI-EKLEG-- 285
E E EA+K + +LR E+Q+ D+L ++ + E+L+
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167
Query: 286 -----ELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRM---SEDLEDELGARSSMD 337
E+ +W+ + +L + Q +L Q + ++ ++LGR + D LGA
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQDA 1226
Query: 338 RKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRA----------QVGDLEE 387
R+ E M ++ E R+E+ E+ +ER +K+ + D E
Sbjct: 1227 RRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYEL 1284
Query: 388 ALARRRRQ----TASALDCDLRASQAALFEKNKEL----ADLKHVHGKLKKQFQEKVAEL 439
L + Q + A +++ ++ ++ +L ++L + + K E + +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 440 AHANRRVEQHEAEVKKLRLRVE---ELKKELAQAEDELD-EAHNQARKLQRSLDEQT--- 492
R EQ AE ++ VE E +++LA+A + +A +A++LQ+ + E+
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 493 -EQSENLQVQLEHLQSRLR--RQQQNAPLFGKIRSARFGTEEAEDGTSDLDED 542
E + + Q Q +Q L+ RQ A + K R A E AE ++E+
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA----EAAERSRLRIEEE 1453
Score = 61.2 bits (147), Expect = 2e-09
Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 52/414 (12%)
Query: 73 EELRLRELEEARAR---AAQMEKTMRRWSD-CTANWREKWSKVRAERNRAREEVRQLRQR 128
E +++++ E AR AAQ +R+ ++ A R K+ E+ +A +E +L+
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2328
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP-EAEREPVRDVG 187
+ L ++ A+ + + Q + E ++LA ++T+ EAER+ ++
Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLA---------EETQGFQRTLEAERQRQLEMS 2379
Query: 188 SERPPGSQELEL-VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATE 246
+E ++ L+L V + ++ ED R +E AT+
Sbjct: 2380 AE----AERLKLRVAEMSRAQARAEEDAQRFRKQA----------EEIGEKLHRTELATQ 2425
Query: 247 EEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLK 306
E+ + + L ++ +S + RE L R EKL+ E ++K EE+ +QE L
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485
Query: 307 QLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL-QAENAAEWGRRERLE 365
Q E + + E + +R + + + ++E+L Q E A RE +
Sbjct: 2486 Q----------ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535
Query: 366 TEKLGLERENKKLRAQVGDLE------EALARRRRQTASALDCDLRASQAALFEKNKELA 419
++ +E+E ++L A + + E RR+++ L+ R + L E+N+ L
Sbjct: 2536 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ +L+ ++ A LAH+ A K L + L A+AE E
Sbjct: 2596 E------QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 30.4 bits (67), Expect = 4.4
Identities = 60/276 (21%), Positives = 104/276 (37%), Gaps = 13/276 (4%)
Query: 242 TAATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
T EE+ L +L L L +SQ ED+L R Q E+
Sbjct: 916 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 975
Query: 298 SKTKQEMLKQLSILKEAH-QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE--N 354
++ + + +S LK+ Q E L R+ A+ E ++ QAE
Sbjct: 976 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1035
Query: 355 AAEWGRRERLETEK-LGLERENKKLRAQVGDLEEALARRRR-QTASALDCDLRASQAALF 412
+ R E EK L L + +LE L + + ++ SA+ + + + +
Sbjct: 1036 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1095
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
+ ++ H + K+ Q A L +E +A +KKLR + E + D
Sbjct: 1096 RGTQGAEEVLRAHEEQLKEAQAVPATLPE----LEATKASLKKLRAQAEAQQPTFDALRD 1151
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR 508
EL A +LQ+ E+ + E + ++ L R
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 96.7 bits (239), Expect = 5e-20
Identities = 132/499 (26%), Positives = 225/499 (45%), Gaps = 63/499 (12%)
Query: 71 SREELRLRELEEARARAAQM--EKTMRRWSDCTANWREKWS------KVRAERNRAREEV 122
+ E RLR L E R Q+ E R+ ++ EK + +++ E A +E
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863
Query: 123 RQLRQRLDALTKELAGARR--ERQEAQGECEARGRELARLRGARG---------VADQTR 171
+RL L ++ A RR E Q AQ + + R LA+LR A V D R
Sbjct: 1864 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLR 1922
Query: 172 DGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
+ E E ++ + G ELEL ++S E++ E L A R +
Sbjct: 1923 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1982
Query: 232 QERSRLPWED----TAATEEEASK--------LTALRLRLDESQKVLLKEREDKLALSRN 279
+ER R E+ + A EEEA++ + L+ +++E+++ L+ER ++ + +R
Sbjct: 1983 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQES-ARQ 2039
Query: 280 IEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRK 339
++ L E +Q +++ EE + K+ + + Q++ + D+L + R+
Sbjct: 2040 LQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------SVLDQLRGEAEAARR 2092
Query: 340 MAELRGEMERLQAENAAEWGRRERLETEKLGLERENK-KLRAQVGDLEEALARRRRQTAS 398
AE E R+QAE A RR+ E E+L E + + RAQ E L + Q A+
Sbjct: 2093 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151
Query: 399 ALDCDLRASQAALFEKNKELADL-KHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLR 457
+A QAAL +K A++ KH K+F E+ R+ Q E E+ LR
Sbjct: 2152 RR---AQAEQAALRQKQAADAEMEKH------KKFAEQTL------RQKAQVEQELTTLR 2196
Query: 458 LRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEH---LQSRLRRQQQ 514
L++EE + ++EL +A + R + E+ +++VQ+E L++R+ + +
Sbjct: 2197 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2256
Query: 515 NAPLFGKIRSARFGTEEAE 533
L K + RF EEAE
Sbjct: 2257 ALILRDKDNTQRFLQEEAE 2275
Score = 88.2 bits (217), Expect = 2e-17
Identities = 135/555 (24%), Positives = 239/555 (43%), Gaps = 102/555 (18%)
Query: 74 ELRLRELEEARARAAQME-KTMRRWSDCT-----ANWREKWSKVRAERNRAREEVRQLRQ 127
E RLR+ E RAR Q+ +T +R ++ A++ EK +++ V QLR+
Sbjct: 1553 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1612
Query: 128 RLDALTKELAGARRERQEAQGECEA---RGRELARLR-------GARGVADQTRDGPEPE 177
+ ++ A A R R+EA+ E E + E RLR + +A + + E
Sbjct: 1613 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEAR--------SLGAGGPRGSS 229
AERE R G ++ EL E L+ + +E + R L A +G
Sbjct: 1673 AERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1731
Query: 230 GRQ----ERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLK-----EREDKLALSRNI 280
RQ E +RL E AAT++ +L A ++ +VLL E E + ++
Sbjct: 1732 QRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1790
Query: 281 EKLEGELSQWKIKYEELSKTK---QEMLKQLSIL-------------------------- 311
++LE E +++ EE ++ + +E +Q +
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1850
Query: 312 ------------KEAHQDELGRMSED-------LEDELGA-RSSMDRKMAELR----GEM 347
KEA + L R++ED LE++ ++ ++ ++A+LR E+
Sbjct: 1851 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1910
Query: 348 ERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRAS 407
ER + +R ++E E L L+ +K A +LE L R R S + LR+
Sbjct: 1911 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR----SNAEDTLRSK 1966
Query: 408 QAALFEKNKE---LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ A E ++ A+ + + +++ Q+ +A A R+ + EV++L+ +VEE +
Sbjct: 1967 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2026
Query: 465 KELAQAEDE----LDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA-PLF 519
+ +AE E L A A+K R E+ + +Q + + LQ L+++Q L
Sbjct: 2027 RLRERAEQESARQLQLAQEAAQK--RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084
Query: 520 GKIRSARFGTEEAED 534
G+ +AR EEAE+
Sbjct: 2085 GEAEAARRAAEEAEE 2099
Score = 84.7 bits (208), Expect = 2e-16
Identities = 117/510 (22%), Positives = 212/510 (41%), Gaps = 58/510 (11%)
Query: 62 ALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREE 121
+L A+ + + + L E+E +A+ + + R +A + + +R +A E+
Sbjct: 1997 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2056
Query: 122 VRQ--LRQRLDALTKELAGARRERQEAQGECEARGR-----ELARLRGARGVADQTRDGP 174
++Q+ L + L + + +GE EA R E AR++ R A R
Sbjct: 2057 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2116
Query: 175 EPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQER 234
E E ++ + R +Q E L K +E+ +A + + E+
Sbjct: 2117 EAERLKQSAEEQAQAR---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2173
Query: 235 SRLPWEDTAATEEEASK-LTALRLRLDES--QKVLLKEREDKLAL-----SRNIEKLEGE 286
+ E T + + + LT LRL+L+E+ QK LL E +L +R ++E E
Sbjct: 2174 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2233
Query: 287 LSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGE 346
L +++ EELSK K + + L +D R L++E KM ++ E
Sbjct: 2234 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF---LQEEA-------EKMKQVAEE 2283
Query: 347 MERLQAENAAEWGRRERLETEKLGLERE--NKKLRAQVGDLEEALARRRRQTASALDCDL 404
RL A E R +L E L +R K L+ ++ ++EA + +L
Sbjct: 2284 AARLSVA-AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2342
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
QA +++KE + +L ++ Q L +R + AE ++L+LRV E+
Sbjct: 2343 AQEQARRLQEDKE-----QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2397
Query: 465 KELAQAEDELDEAHNQARK-----------------LQRSLDEQTEQS----ENLQVQLE 503
+ A+AE++ QA + L ++L+ Q +QS E L+ +
Sbjct: 2398 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2457
Query: 504 HLQSRLRRQQQNAPLFGKIRSARFGTEEAE 533
L+ + QQ A L +++S T + E
Sbjct: 2458 ELEREKEKLQQEAKLL-QLKSEEMQTVQQE 2486
Score = 77.0 bits (188), Expect = 4e-14
Identities = 111/459 (24%), Positives = 196/459 (42%), Gaps = 27/459 (5%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANW---REKWSKVRAERNRAREEVRQLR 126
E+ E RLR EE R Q+E T R+ R + + A++ +A+EE +LR
Sbjct: 1445 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1504
Query: 127 QRLDALTK-----ELAGARRERQEAQGECEARGRELARLRGARGVADQT-RDGPEPEAER 180
+++ ++ E+ A R + EA+ E + R L L R A++ R + E ER
Sbjct: 1505 RQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVER 1563
Query: 181 EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE---RSRL 237
V E S E EL +S S E++ RSL + R+E R++
Sbjct: 1564 ARQVQVALETAQRSAEAEL-QSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQ 1620
Query: 238 PWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
E A EE +L +L+ +E+ ++ L+ E +A +++ + E E + + + E
Sbjct: 1621 QAEAERAREEAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREAR 1678
Query: 298 SKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAE 357
+ K E + Q EL + + +L ++ R AE E+ RL+AE
Sbjct: 1679 RRGKAEE-------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQG 1729
Query: 358 WGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKE 417
+R+ LE E L+RE + +LE LA+ R + L RA + + K
Sbjct: 1730 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 418 LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEA 477
L+ G+ ++ +E A A Q + + + E ++ LA+ + EA
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1849
Query: 478 HNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA 516
+ + +L E+ ++E L+ E + RR ++ A
Sbjct: 1850 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Score = 73.6 bits (179), Expect = 5e-13
Identities = 113/498 (22%), Positives = 212/498 (42%), Gaps = 53/498 (10%)
Query: 72 REELR-LREL-EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQL---- 125
R+ELR +E+ E + R + + + RW + A E+W V A+ + + E+ QL
Sbjct: 1154 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1213
Query: 126 ---RQRLDALTKELAGARRERQEAQGECEARGREL-ARLRGARGVADQTRDGPE--PEAE 179
R+ D L L ARR +++ Q A + + +LR + + ++ E E +
Sbjct: 1214 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1273
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
R + + + + EL+LV + P S A P+ SG E +
Sbjct: 1274 RFAKQYINAIK---DYELQLVTYKAQLEPVASP---------AKKPKVQSG-SESVIQEY 1320
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIE------KLEGELSQWKIK 293
D E + LT+ ++ S+ + E E++LA + E ++E L + +
Sbjct: 1321 VDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379
Query: 294 YEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE 353
E ++ K + ++ L++ Q+E+ R E D + S+ ++ +LR E AE
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AE 1436
Query: 354 NAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFE 413
A+ + E E +L +E E + +R Q+ EA R+R + +L+A +A E
Sbjct: 1437 IQAKARQAEAAERSRLRIEEEIRVVRLQL----EATERQR----GGAEGELQALRARAEE 1488
Query: 414 KNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ + +L++Q Q++ ++R Q E E+ E +E +A
Sbjct: 1489 AEAQKRQAQEEAERLRRQVQDE-------SQRKRQAEVELASRVKAEAEAAREKQRALQA 1541
Query: 474 LDEAHNQARKLQRSLDE-QTEQSENLQVQLEHLQ--SRLRRQQQNAPLFGKIRSARFGTE 530
L+E QA + +R L + + E++ +QV LE Q + Q + A K +
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601
Query: 531 EAEDGTSDLDEDEDLQIQ 548
E + L E+ + + Q
Sbjct: 1602 EEHVAVAQLREEAERRAQ 1619
Score = 68.2 bits (165), Expect = 2e-11
Identities = 110/497 (22%), Positives = 217/497 (43%), Gaps = 85/497 (17%)
Query: 73 EELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ-------- 124
E+LR +E E+ AR AQ E+ R EK K + R + +V Q
Sbjct: 2140 EKLR-KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2198
Query: 125 ----------LRQRLDALTKELAGARRERQEAQGEC---EARGRELARLRG---ARGVA- 167
L + L L E A R+R + + E + EL++L+ A A
Sbjct: 2199 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2258
Query: 168 -----DQTRDGPEPEAER-EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLG 221
D T+ + EAE+ + V + + +QE + L + ED + R+L
Sbjct: 2259 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALA 2312
Query: 222 AGGPRGS-SGRQERSRLPWE-DTAATEEEASKLTALRLRLDESQ-------------KVL 266
+ QE +RL E + ++E ++ A RL+ D+ Q + L
Sbjct: 2313 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2372
Query: 267 LKEREDKLALSRNIEKLE---GELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMS 323
ER+ +L +S E+L+ E+S+ + + EE ++ ++ +++ ++ H+ EL
Sbjct: 2373 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHRTEL---- 2426
Query: 324 EDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE--RLETEKLGLERENKKLRAQ 381
++ ++ E++R Q+++ AE R LE EK L++E K L+ +
Sbjct: 2427 ----------ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2476
Query: 382 VGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAH 441
+++ + Q AL + + +L ++ + + K KL++ FQ++VA+
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK---AKLEQLFQDEVAKAQQ 2533
Query: 442 AN----RRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ----TE 493
R+ +Q E E ++L +EE ++ +AE+ + + ++L++ +Q E
Sbjct: 2534 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2593
Query: 494 QSENLQVQLEHLQSRLR 510
+++ L+ QL+ L+ + R
Sbjct: 2594 ENQRLREQLQLLEEQHR 2610
Score = 63.5 bits (153), Expect = 5e-10
Identities = 122/533 (22%), Positives = 223/533 (41%), Gaps = 76/533 (14%)
Query: 59 PAPALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRA 118
P L+A+ ++ S ++L ++ + AQ E +R C + ++ ++ A R
Sbjct: 952 PEDRLMAEREYGSCSH-HYQQLLQSLEQGAQEESRCQR---CISELKDIRLQLEACETRT 1007
Query: 119 REEVRQLRQRLDAL-TKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPE 177
V +LR LD +E A E+Q+AQ E E G+ +ARL A++ PEP
Sbjct: 1008 ---VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPS 1061
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRL 237
+R ELEL L+ + S E + RG+ G +E R
Sbjct: 1062 PAAPTLR----------SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1111
Query: 238 PWED--------TAATEEEASKLTALRLRLD-ESQKVLLKEREDKLALSRNI-EKLEG-- 285
E E EA+K + +LR E+Q+ D+L ++ + E+L+
Sbjct: 1112 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1171
Query: 286 -----ELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRM---SEDLEDELGARSSMD 337
E+ +W+ + +L + Q +L Q + ++ ++LGR + D LGA
Sbjct: 1172 GERDVEVERWRERVAQLLERWQAVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQDA 1230
Query: 338 RKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRA----------QVGDLEE 387
R+ E M ++ E R+E+ E+ +ER +K+ + D E
Sbjct: 1231 RRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYEL 1288
Query: 388 ALARRRRQ----TASALDCDLRASQAALFEKNKEL----ADLKHVHGKLKKQFQEKVAEL 439
L + Q + A +++ ++ ++ +L ++L + + K E + +
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348
Query: 440 AHANRRVEQHEAEVKKLRLRVE---ELKKELAQAEDELD-EAHNQARKLQRSLDEQT--- 492
R EQ AE ++ VE E +++LA+A + +A +A++LQ+ + E+
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 493 -EQSENLQVQLEHLQSRLR--RQQQNAPLFGKIRSARFGTEEAEDGTSDLDED 542
E + + Q Q +Q L+ RQ A + K R A E AE ++E+
Sbjct: 1409 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA----EAAERSRLRIEEE 1457
Score = 61.2 bits (147), Expect = 2e-09
Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 52/414 (12%)
Query: 73 EELRLRELEEARAR---AAQMEKTMRRWSD-CTANWREKWSKVRAERNRAREEVRQLRQR 128
E +++++ E AR AAQ +R+ ++ A R K+ E+ +A +E +L+
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2332
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP-EAEREPVRDVG 187
+ L ++ A+ + + Q + E ++LA ++T+ EAER+ ++
Sbjct: 2333 AELLQQQKELAQEQARRLQEDKEQMAQQLA---------EETQGFQRTLEAERQRQLEMS 2383
Query: 188 SERPPGSQELEL-VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATE 246
+E ++ L+L V + ++ ED R +E AT+
Sbjct: 2384 AE----AERLKLRVAEMSRAQARAEEDAQRFRKQA----------EEIGEKLHRTELATQ 2429
Query: 247 EEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLK 306
E+ + + L ++ +S + RE L R EKL+ E ++K EE+ +QE L
Sbjct: 2430 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2489
Query: 307 QLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL-QAENAAEWGRRERLE 365
Q E + + E + +R + + + ++E+L Q E A RE +
Sbjct: 2490 Q----------ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2539
Query: 366 TEKLGLERENKKLRAQVGDLE------EALARRRRQTASALDCDLRASQAALFEKNKELA 419
++ +E+E ++L A + + E RR+++ L+ R + L E+N+ L
Sbjct: 2540 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2599
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ +L+ ++ A LAH+ A K L + L A+AE E
Sbjct: 2600 E------QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2647
Score = 30.4 bits (67), Expect = 4.4
Identities = 60/276 (21%), Positives = 104/276 (37%), Gaps = 13/276 (4%)
Query: 242 TAATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
T EE+ L +L L L +SQ ED+L R Q E+
Sbjct: 920 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 979
Query: 298 SKTKQEMLKQLSILKEAH-QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE--N 354
++ + + +S LK+ Q E L R+ A+ E ++ QAE
Sbjct: 980 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1039
Query: 355 AAEWGRRERLETEK-LGLERENKKLRAQVGDLEEALARRRR-QTASALDCDLRASQAALF 412
+ R E EK L L + +LE L + + ++ SA+ + + + +
Sbjct: 1040 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1099
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
+ ++ H + K+ Q A L +E +A +KKLR + E + D
Sbjct: 1100 RGTQGAEEVLRAHEEQLKEAQAVPATLPE----LEATKASLKKLRAQAEAQQPTFDALRD 1155
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR 508
EL A +LQ+ E+ + E + ++ L R
Sbjct: 1156 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1191
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 96.7 bits (239), Expect = 5e-20
Identities = 132/499 (26%), Positives = 225/499 (45%), Gaps = 63/499 (12%)
Query: 71 SREELRLRELEEARARAAQM--EKTMRRWSDCTANWREKWS------KVRAERNRAREEV 122
+ E RLR L E R Q+ E R+ ++ EK + +++ E A +E
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859
Query: 123 RQLRQRLDALTKELAGARR--ERQEAQGECEARGRELARLRGARG---------VADQTR 171
+RL L ++ A RR E Q AQ + + R LA+LR A V D R
Sbjct: 1860 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLR 1918
Query: 172 DGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
+ E E ++ + G ELEL ++S E++ E L A R +
Sbjct: 1919 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1978
Query: 232 QERSRLPWED----TAATEEEASK--------LTALRLRLDESQKVLLKEREDKLALSRN 279
+ER R E+ + A EEEA++ + L+ +++E+++ L+ER ++ + +R
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQES-ARQ 2035
Query: 280 IEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRK 339
++ L E +Q +++ EE + K+ + + Q++ + D+L + R+
Sbjct: 2036 LQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------SVLDQLRGEAEAARR 2088
Query: 340 MAELRGEMERLQAENAAEWGRRERLETEKLGLERENK-KLRAQVGDLEEALARRRRQTAS 398
AE E R+QAE A RR+ E E+L E + + RAQ E L + Q A+
Sbjct: 2089 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 399 ALDCDLRASQAALFEKNKELADL-KHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLR 457
+A QAAL +K A++ KH K+F E+ R+ Q E E+ LR
Sbjct: 2148 RR---AQAEQAALRQKQAADAEMEKH------KKFAEQTL------RQKAQVEQELTTLR 2192
Query: 458 LRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEH---LQSRLRRQQQ 514
L++EE + ++EL +A + R + E+ +++VQ+E L++R+ + +
Sbjct: 2193 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2252
Query: 515 NAPLFGKIRSARFGTEEAE 533
L K + RF EEAE
Sbjct: 2253 ALILRDKDNTQRFLQEEAE 2271
Score = 88.2 bits (217), Expect = 2e-17
Identities = 135/555 (24%), Positives = 239/555 (43%), Gaps = 102/555 (18%)
Query: 74 ELRLRELEEARARAAQME-KTMRRWSDCT-----ANWREKWSKVRAERNRAREEVRQLRQ 127
E RLR+ E RAR Q+ +T +R ++ A++ EK +++ V QLR+
Sbjct: 1549 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608
Query: 128 RLDALTKELAGARRERQEAQGECEA---RGRELARLR-------GARGVADQTRDGPEPE 177
+ ++ A A R R+EA+ E E + E RLR + +A + + E
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEAR--------SLGAGGPRGSS 229
AERE R G ++ EL E L+ + +E + R L A +G
Sbjct: 1669 AERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1727
Query: 230 GRQ----ERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLK-----EREDKLALSRNI 280
RQ E +RL E AAT++ +L A ++ +VLL E E + ++
Sbjct: 1728 QRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1786
Query: 281 EKLEGELSQWKIKYEELSKTK---QEMLKQLSIL-------------------------- 311
++LE E +++ EE ++ + +E +Q +
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1846
Query: 312 ------------KEAHQDELGRMSED-------LEDELGA-RSSMDRKMAELR----GEM 347
KEA + L R++ED LE++ ++ ++ ++A+LR E+
Sbjct: 1847 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1906
Query: 348 ERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRAS 407
ER + +R ++E E L L+ +K A +LE L R R S + LR+
Sbjct: 1907 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR----SNAEDTLRSK 1962
Query: 408 QAALFEKNKE---LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ A E ++ A+ + + +++ Q+ +A A R+ + EV++L+ +VEE +
Sbjct: 1963 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2022
Query: 465 KELAQAEDE----LDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA-PLF 519
+ +AE E L A A+K R E+ + +Q + + LQ L+++Q L
Sbjct: 2023 RLRERAEQESARQLQLAQEAAQK--RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 520 GKIRSARFGTEEAED 534
G+ +AR EEAE+
Sbjct: 2081 GEAEAARRAAEEAEE 2095
Score = 84.7 bits (208), Expect = 2e-16
Identities = 117/510 (22%), Positives = 212/510 (41%), Gaps = 58/510 (11%)
Query: 62 ALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREE 121
+L A+ + + + L E+E +A+ + + R +A + + +R +A E+
Sbjct: 1993 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Query: 122 VRQ--LRQRLDALTKELAGARRERQEAQGECEARGR-----ELARLRGARGVADQTRDGP 174
++Q+ L + L + + +GE EA R E AR++ R A R
Sbjct: 2053 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2112
Query: 175 EPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQER 234
E E ++ + R +Q E L K +E+ +A + + E+
Sbjct: 2113 EAERLKQSAEEQAQAR---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2169
Query: 235 SRLPWEDTAATEEEASK-LTALRLRLDES--QKVLLKEREDKLAL-----SRNIEKLEGE 286
+ E T + + + LT LRL+L+E+ QK LL E +L +R ++E E
Sbjct: 2170 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2229
Query: 287 LSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGE 346
L +++ EELSK K + + L +D R L++E KM ++ E
Sbjct: 2230 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF---LQEEA-------EKMKQVAEE 2279
Query: 347 MERLQAENAAEWGRRERLETEKLGLERE--NKKLRAQVGDLEEALARRRRQTASALDCDL 404
RL A E R +L E L +R K L+ ++ ++EA + +L
Sbjct: 2280 AARLSVA-AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2338
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
QA +++KE + +L ++ Q L +R + AE ++L+LRV E+
Sbjct: 2339 AQEQARRLQEDKE-----QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2393
Query: 465 KELAQAEDELDEAHNQARK-----------------LQRSLDEQTEQS----ENLQVQLE 503
+ A+AE++ QA + L ++L+ Q +QS E L+ +
Sbjct: 2394 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2453
Query: 504 HLQSRLRRQQQNAPLFGKIRSARFGTEEAE 533
L+ + QQ A L +++S T + E
Sbjct: 2454 ELEREKEKLQQEAKLL-QLKSEEMQTVQQE 2482
Score = 77.0 bits (188), Expect = 4e-14
Identities = 111/459 (24%), Positives = 196/459 (42%), Gaps = 27/459 (5%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANW---REKWSKVRAERNRAREEVRQLR 126
E+ E RLR EE R Q+E T R+ R + + A++ +A+EE +LR
Sbjct: 1441 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1500
Query: 127 QRLDALTK-----ELAGARRERQEAQGECEARGRELARLRGARGVADQT-RDGPEPEAER 180
+++ ++ E+ A R + EA+ E + R L L R A++ R + E ER
Sbjct: 1501 RQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVER 1559
Query: 181 EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE---RSRL 237
V E S E EL +S S E++ RSL + R+E R++
Sbjct: 1560 ARQVQVALETAQRSAEAEL-QSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQ 1616
Query: 238 PWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
E A EE +L +L+ +E+ ++ L+ E +A +++ + E E + + + E
Sbjct: 1617 QAEAERAREEAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 298 SKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAE 357
+ K E + Q EL + + +L ++ R AE E+ RL+AE
Sbjct: 1675 RRGKAEE-------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQG 1725
Query: 358 WGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKE 417
+R+ LE E L+RE + +LE LA+ R + L RA + + K
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 418 LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEA 477
L+ G+ ++ +E A A Q + + + E ++ LA+ + EA
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845
Query: 478 HNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA 516
+ + +L E+ ++E L+ E + RR ++ A
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Score = 73.6 bits (179), Expect = 5e-13
Identities = 113/498 (22%), Positives = 212/498 (42%), Gaps = 53/498 (10%)
Query: 72 REELR-LREL-EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQL---- 125
R+ELR +E+ E + R + + + RW + A E+W V A+ + + E+ QL
Sbjct: 1150 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1209
Query: 126 ---RQRLDALTKELAGARRERQEAQGECEARGREL-ARLRGARGVADQTRDGPE--PEAE 179
R+ D L L ARR +++ Q A + + +LR + + ++ E E +
Sbjct: 1210 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1269
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
R + + + + EL+LV + P S A P+ SG E +
Sbjct: 1270 RFAKQYINAIK---DYELQLVTYKAQLEPVASP---------AKKPKVQSG-SESVIQEY 1316
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIE------KLEGELSQWKIK 293
D E + LT+ ++ S+ + E E++LA + E ++E L + +
Sbjct: 1317 VDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 294 YEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE 353
E ++ K + ++ L++ Q+E+ R E D + S+ ++ +LR E AE
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AE 1432
Query: 354 NAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFE 413
A+ + E E +L +E E + +R Q+ EA R+R + +L+A +A E
Sbjct: 1433 IQAKARQAEAAERSRLRIEEEIRVVRLQL----EATERQR----GGAEGELQALRARAEE 1484
Query: 414 KNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ + +L++Q Q++ ++R Q E E+ E +E +A
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQDE-------SQRKRQAEVELASRVKAEAEAAREKQRALQA 1537
Query: 474 LDEAHNQARKLQRSLDE-QTEQSENLQVQLEHLQ--SRLRRQQQNAPLFGKIRSARFGTE 530
L+E QA + +R L + + E++ +QV LE Q + Q + A K +
Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 531 EAEDGTSDLDEDEDLQIQ 548
E + L E+ + + Q
Sbjct: 1598 EEHVAVAQLREEAERRAQ 1615
Score = 68.2 bits (165), Expect = 2e-11
Identities = 110/497 (22%), Positives = 217/497 (43%), Gaps = 85/497 (17%)
Query: 73 EELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ-------- 124
E+LR +E E+ AR AQ E+ R EK K + R + +V Q
Sbjct: 2136 EKLR-KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2194
Query: 125 ----------LRQRLDALTKELAGARRERQEAQGEC---EARGRELARLRG---ARGVA- 167
L + L L E A R+R + + E + EL++L+ A A
Sbjct: 2195 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2254
Query: 168 -----DQTRDGPEPEAER-EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLG 221
D T+ + EAE+ + V + + +QE + L + ED + R+L
Sbjct: 2255 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALA 2308
Query: 222 AGGPRGS-SGRQERSRLPWE-DTAATEEEASKLTALRLRLDESQ-------------KVL 266
+ QE +RL E + ++E ++ A RL+ D+ Q + L
Sbjct: 2309 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2368
Query: 267 LKEREDKLALSRNIEKLE---GELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMS 323
ER+ +L +S E+L+ E+S+ + + EE ++ ++ +++ ++ H+ EL
Sbjct: 2369 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHRTEL---- 2422
Query: 324 EDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE--RLETEKLGLERENKKLRAQ 381
++ ++ E++R Q+++ AE R LE EK L++E K L+ +
Sbjct: 2423 ----------ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 382 VGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAH 441
+++ + Q AL + + +L ++ + + K KL++ FQ++VA+
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK---AKLEQLFQDEVAKAQQ 2529
Query: 442 AN----RRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ----TE 493
R+ +Q E E ++L +EE ++ +AE+ + + ++L++ +Q E
Sbjct: 2530 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2589
Query: 494 QSENLQVQLEHLQSRLR 510
+++ L+ QL+ L+ + R
Sbjct: 2590 ENQRLREQLQLLEEQHR 2606
Score = 63.5 bits (153), Expect = 5e-10
Identities = 122/533 (22%), Positives = 223/533 (41%), Gaps = 76/533 (14%)
Query: 59 PAPALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRA 118
P L+A+ ++ S ++L ++ + AQ E +R C + ++ ++ A R
Sbjct: 948 PEDRLMAEREYGSCSH-HYQQLLQSLEQGAQEESRCQR---CISELKDIRLQLEACETRT 1003
Query: 119 REEVRQLRQRLDAL-TKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPE 177
V +LR LD +E A E+Q+AQ E E G+ +ARL A++ PEP
Sbjct: 1004 ---VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPS 1057
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRL 237
+R ELEL L+ + S E + RG+ G +E R
Sbjct: 1058 PAAPTLR----------SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1107
Query: 238 PWED--------TAATEEEASKLTALRLRLD-ESQKVLLKEREDKLALSRNI-EKLEG-- 285
E E EA+K + +LR E+Q+ D+L ++ + E+L+
Sbjct: 1108 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1167
Query: 286 -----ELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRM---SEDLEDELGARSSMD 337
E+ +W+ + +L + Q +L Q + ++ ++LGR + D LGA
Sbjct: 1168 GERDVEVERWRERVAQLLERWQAVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQDA 1226
Query: 338 RKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRA----------QVGDLEE 387
R+ E M ++ E R+E+ E+ +ER +K+ + D E
Sbjct: 1227 RRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYEL 1284
Query: 388 ALARRRRQ----TASALDCDLRASQAALFEKNKEL----ADLKHVHGKLKKQFQEKVAEL 439
L + Q + A +++ ++ ++ +L ++L + + K E + +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 440 AHANRRVEQHEAEVKKLRLRVE---ELKKELAQAEDELD-EAHNQARKLQRSLDEQT--- 492
R EQ AE ++ VE E +++LA+A + +A +A++LQ+ + E+
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 493 -EQSENLQVQLEHLQSRLR--RQQQNAPLFGKIRSARFGTEEAEDGTSDLDED 542
E + + Q Q +Q L+ RQ A + K R A E AE ++E+
Sbjct: 1405 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA----EAAERSRLRIEEE 1453
Score = 61.2 bits (147), Expect = 2e-09
Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 52/414 (12%)
Query: 73 EELRLRELEEARAR---AAQMEKTMRRWSD-CTANWREKWSKVRAERNRAREEVRQLRQR 128
E +++++ E AR AAQ +R+ ++ A R K+ E+ +A +E +L+
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2328
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP-EAEREPVRDVG 187
+ L ++ A+ + + Q + E ++LA ++T+ EAER+ ++
Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLA---------EETQGFQRTLEAERQRQLEMS 2379
Query: 188 SERPPGSQELEL-VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATE 246
+E ++ L+L V + ++ ED R +E AT+
Sbjct: 2380 AE----AERLKLRVAEMSRAQARAEEDAQRFRKQA----------EEIGEKLHRTELATQ 2425
Query: 247 EEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLK 306
E+ + + L ++ +S + RE L R EKL+ E ++K EE+ +QE L
Sbjct: 2426 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2485
Query: 307 QLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL-QAENAAEWGRRERLE 365
Q E + + E + +R + + + ++E+L Q E A RE +
Sbjct: 2486 Q----------ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535
Query: 366 TEKLGLERENKKLRAQVGDLE------EALARRRRQTASALDCDLRASQAALFEKNKELA 419
++ +E+E ++L A + + E RR+++ L+ R + L E+N+ L
Sbjct: 2536 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ +L+ ++ A LAH+ A K L + L A+AE E
Sbjct: 2596 E------QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 30.4 bits (67), Expect = 4.4
Identities = 60/276 (21%), Positives = 104/276 (37%), Gaps = 13/276 (4%)
Query: 242 TAATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
T EE+ L +L L L +SQ ED+L R Q E+
Sbjct: 916 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 975
Query: 298 SKTKQEMLKQLSILKEAH-QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE--N 354
++ + + +S LK+ Q E L R+ A+ E ++ QAE
Sbjct: 976 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1035
Query: 355 AAEWGRRERLETEK-LGLERENKKLRAQVGDLEEALARRRR-QTASALDCDLRASQAALF 412
+ R E EK L L + +LE L + + ++ SA+ + + + +
Sbjct: 1036 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1095
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
+ ++ H + K+ Q A L +E +A +KKLR + E + D
Sbjct: 1096 RGTQGAEEVLRAHEEQLKEAQAVPATLPE----LEATKASLKKLRAQAEAQQPTFDALRD 1151
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR 508
EL A +LQ+ E+ + E + ++ L R
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 96.7 bits (239), Expect = 5e-20
Identities = 132/499 (26%), Positives = 225/499 (45%), Gaps = 63/499 (12%)
Query: 71 SREELRLRELEEARARAAQM--EKTMRRWSDCTANWREKWS------KVRAERNRAREEV 122
+ E RLR L E R Q+ E R+ ++ EK + +++ E A +E
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1827
Query: 123 RQLRQRLDALTKELAGARR--ERQEAQGECEARGRELARLRGARG---------VADQTR 171
+RL L ++ A RR E Q AQ + + R LA+LR A V D R
Sbjct: 1828 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLR 1886
Query: 172 DGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
+ E E ++ + G ELEL ++S E++ E L A R +
Sbjct: 1887 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1946
Query: 232 QERSRLPWED----TAATEEEASK--------LTALRLRLDESQKVLLKEREDKLALSRN 279
+ER R E+ + A EEEA++ + L+ +++E+++ L+ER ++ + +R
Sbjct: 1947 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQES-ARQ 2003
Query: 280 IEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRK 339
++ L E +Q +++ EE + K+ + + Q++ + D+L + R+
Sbjct: 2004 LQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------SVLDQLRGEAEAARR 2056
Query: 340 MAELRGEMERLQAENAAEWGRRERLETEKLGLERENK-KLRAQVGDLEEALARRRRQTAS 398
AE E R+QAE A RR+ E E+L E + + RAQ E L + Q A+
Sbjct: 2057 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115
Query: 399 ALDCDLRASQAALFEKNKELADL-KHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLR 457
+A QAAL +K A++ KH K+F E+ R+ Q E E+ LR
Sbjct: 2116 RR---AQAEQAALRQKQAADAEMEKH------KKFAEQTL------RQKAQVEQELTTLR 2160
Query: 458 LRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEH---LQSRLRRQQQ 514
L++EE + ++EL +A + R + E+ +++VQ+E L++R+ + +
Sbjct: 2161 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2220
Query: 515 NAPLFGKIRSARFGTEEAE 533
L K + RF EEAE
Sbjct: 2221 ALILRDKDNTQRFLQEEAE 2239
Score = 88.2 bits (217), Expect = 2e-17
Identities = 135/555 (24%), Positives = 239/555 (43%), Gaps = 102/555 (18%)
Query: 74 ELRLRELEEARARAAQME-KTMRRWSDCT-----ANWREKWSKVRAERNRAREEVRQLRQ 127
E RLR+ E RAR Q+ +T +R ++ A++ EK +++ V QLR+
Sbjct: 1517 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1576
Query: 128 RLDALTKELAGARRERQEAQGECEA---RGRELARLR-------GARGVADQTRDGPEPE 177
+ ++ A A R R+EA+ E E + E RLR + +A + + E
Sbjct: 1577 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEAR--------SLGAGGPRGSS 229
AERE R G ++ EL E L+ + +E + R L A +G
Sbjct: 1637 AERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1695
Query: 230 GRQ----ERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLK-----EREDKLALSRNI 280
RQ E +RL E AAT++ +L A ++ +VLL E E + ++
Sbjct: 1696 QRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1754
Query: 281 EKLEGELSQWKIKYEELSKTK---QEMLKQLSIL-------------------------- 311
++LE E +++ EE ++ + +E +Q +
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1814
Query: 312 ------------KEAHQDELGRMSED-------LEDELGA-RSSMDRKMAELR----GEM 347
KEA + L R++ED LE++ ++ ++ ++A+LR E+
Sbjct: 1815 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1874
Query: 348 ERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRAS 407
ER + +R ++E E L L+ +K A +LE L R R S + LR+
Sbjct: 1875 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR----SNAEDTLRSK 1930
Query: 408 QAALFEKNKE---LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ A E ++ A+ + + +++ Q+ +A A R+ + EV++L+ +VEE +
Sbjct: 1931 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 1990
Query: 465 KELAQAEDE----LDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA-PLF 519
+ +AE E L A A+K R E+ + +Q + + LQ L+++Q L
Sbjct: 1991 RLRERAEQESARQLQLAQEAAQK--RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048
Query: 520 GKIRSARFGTEEAED 534
G+ +AR EEAE+
Sbjct: 2049 GEAEAARRAAEEAEE 2063
Score = 84.7 bits (208), Expect = 2e-16
Identities = 117/510 (22%), Positives = 212/510 (41%), Gaps = 58/510 (11%)
Query: 62 ALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREE 121
+L A+ + + + L E+E +A+ + + R +A + + +R +A E+
Sbjct: 1961 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2020
Query: 122 VRQ--LRQRLDALTKELAGARRERQEAQGECEARGR-----ELARLRGARGVADQTRDGP 174
++Q+ L + L + + +GE EA R E AR++ R A R
Sbjct: 2021 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2080
Query: 175 EPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQER 234
E E ++ + R +Q E L K +E+ +A + + E+
Sbjct: 2081 EAERLKQSAEEQAQAR---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2137
Query: 235 SRLPWEDTAATEEEASK-LTALRLRLDES--QKVLLKEREDKLAL-----SRNIEKLEGE 286
+ E T + + + LT LRL+L+E+ QK LL E +L +R ++E E
Sbjct: 2138 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2197
Query: 287 LSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGE 346
L +++ EELSK K + + L +D R L++E KM ++ E
Sbjct: 2198 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF---LQEEA-------EKMKQVAEE 2247
Query: 347 MERLQAENAAEWGRRERLETEKLGLERE--NKKLRAQVGDLEEALARRRRQTASALDCDL 404
RL A E R +L E L +R K L+ ++ ++EA + +L
Sbjct: 2248 AARLSVA-AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2306
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
QA +++KE + +L ++ Q L +R + AE ++L+LRV E+
Sbjct: 2307 AQEQARRLQEDKE-----QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2361
Query: 465 KELAQAEDELDEAHNQARK-----------------LQRSLDEQTEQS----ENLQVQLE 503
+ A+AE++ QA + L ++L+ Q +QS E L+ +
Sbjct: 2362 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2421
Query: 504 HLQSRLRRQQQNAPLFGKIRSARFGTEEAE 533
L+ + QQ A L +++S T + E
Sbjct: 2422 ELEREKEKLQQEAKLL-QLKSEEMQTVQQE 2450
Score = 77.0 bits (188), Expect = 4e-14
Identities = 111/459 (24%), Positives = 196/459 (42%), Gaps = 27/459 (5%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANW---REKWSKVRAERNRAREEVRQLR 126
E+ E RLR EE R Q+E T R+ R + + A++ +A+EE +LR
Sbjct: 1409 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1468
Query: 127 QRLDALTK-----ELAGARRERQEAQGECEARGRELARLRGARGVADQT-RDGPEPEAER 180
+++ ++ E+ A R + EA+ E + R L L R A++ R + E ER
Sbjct: 1469 RQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVER 1527
Query: 181 EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE---RSRL 237
V E S E EL +S S E++ RSL + R+E R++
Sbjct: 1528 ARQVQVALETAQRSAEAEL-QSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQ 1584
Query: 238 PWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
E A EE +L +L+ +E+ ++ L+ E +A +++ + E E + + + E
Sbjct: 1585 QAEAERAREEAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREAR 1642
Query: 298 SKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAE 357
+ K E + Q EL + + +L ++ R AE E+ RL+AE
Sbjct: 1643 RRGKAEE-------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQG 1693
Query: 358 WGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKE 417
+R+ LE E L+RE + +LE LA+ R + L RA + + K
Sbjct: 1694 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 418 LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEA 477
L+ G+ ++ +E A A Q + + + E ++ LA+ + EA
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1813
Query: 478 HNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA 516
+ + +L E+ ++E L+ E + RR ++ A
Sbjct: 1814 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Score = 73.6 bits (179), Expect = 5e-13
Identities = 113/498 (22%), Positives = 212/498 (42%), Gaps = 53/498 (10%)
Query: 72 REELR-LREL-EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQL---- 125
R+ELR +E+ E + R + + + RW + A E+W V A+ + + E+ QL
Sbjct: 1118 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1177
Query: 126 ---RQRLDALTKELAGARRERQEAQGECEARGREL-ARLRGARGVADQTRDGPE--PEAE 179
R+ D L L ARR +++ Q A + + +LR + + ++ E E +
Sbjct: 1178 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1237
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
R + + + + EL+LV + P S A P+ SG E +
Sbjct: 1238 RFAKQYINAIK---DYELQLVTYKAQLEPVASP---------AKKPKVQSG-SESVIQEY 1284
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIE------KLEGELSQWKIK 293
D E + LT+ ++ S+ + E E++LA + E ++E L + +
Sbjct: 1285 VDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343
Query: 294 YEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE 353
E ++ K + ++ L++ Q+E+ R E D + S+ ++ +LR E AE
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AE 1400
Query: 354 NAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFE 413
A+ + E E +L +E E + +R Q+ EA R+R + +L+A +A E
Sbjct: 1401 IQAKARQAEAAERSRLRIEEEIRVVRLQL----EATERQR----GGAEGELQALRARAEE 1452
Query: 414 KNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ + +L++Q Q++ ++R Q E E+ E +E +A
Sbjct: 1453 AEAQKRQAQEEAERLRRQVQDE-------SQRKRQAEVELASRVKAEAEAAREKQRALQA 1505
Query: 474 LDEAHNQARKLQRSLDE-QTEQSENLQVQLEHLQ--SRLRRQQQNAPLFGKIRSARFGTE 530
L+E QA + +R L + + E++ +QV LE Q + Q + A K +
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565
Query: 531 EAEDGTSDLDEDEDLQIQ 548
E + L E+ + + Q
Sbjct: 1566 EEHVAVAQLREEAERRAQ 1583
Score = 68.2 bits (165), Expect = 2e-11
Identities = 110/497 (22%), Positives = 217/497 (43%), Gaps = 85/497 (17%)
Query: 73 EELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ-------- 124
E+LR +E E+ AR AQ E+ R EK K + R + +V Q
Sbjct: 2104 EKLR-KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2162
Query: 125 ----------LRQRLDALTKELAGARRERQEAQGEC---EARGRELARLRG---ARGVA- 167
L + L L E A R+R + + E + EL++L+ A A
Sbjct: 2163 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2222
Query: 168 -----DQTRDGPEPEAER-EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLG 221
D T+ + EAE+ + V + + +QE + L + ED + R+L
Sbjct: 2223 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALA 2276
Query: 222 AGGPRGS-SGRQERSRLPWE-DTAATEEEASKLTALRLRLDESQ-------------KVL 266
+ QE +RL E + ++E ++ A RL+ D+ Q + L
Sbjct: 2277 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2336
Query: 267 LKEREDKLALSRNIEKLE---GELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMS 323
ER+ +L +S E+L+ E+S+ + + EE ++ ++ +++ ++ H+ EL
Sbjct: 2337 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHRTEL---- 2390
Query: 324 EDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE--RLETEKLGLERENKKLRAQ 381
++ ++ E++R Q+++ AE R LE EK L++E K L+ +
Sbjct: 2391 ----------ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2440
Query: 382 VGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAH 441
+++ + Q AL + + +L ++ + + K KL++ FQ++VA+
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK---AKLEQLFQDEVAKAQQ 2497
Query: 442 AN----RRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ----TE 493
R+ +Q E E ++L +EE ++ +AE+ + + ++L++ +Q E
Sbjct: 2498 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2557
Query: 494 QSENLQVQLEHLQSRLR 510
+++ L+ QL+ L+ + R
Sbjct: 2558 ENQRLREQLQLLEEQHR 2574
Score = 63.5 bits (153), Expect = 5e-10
Identities = 122/533 (22%), Positives = 223/533 (41%), Gaps = 76/533 (14%)
Query: 59 PAPALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRA 118
P L+A+ ++ S ++L ++ + AQ E +R C + ++ ++ A R
Sbjct: 916 PEDRLMAEREYGSCSH-HYQQLLQSLEQGAQEESRCQR---CISELKDIRLQLEACETRT 971
Query: 119 REEVRQLRQRLDAL-TKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPE 177
V +LR LD +E A E+Q+AQ E E G+ +ARL A++ PEP
Sbjct: 972 ---VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPS 1025
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRL 237
+R ELEL L+ + S E + RG+ G +E R
Sbjct: 1026 PAAPTLR----------SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1075
Query: 238 PWED--------TAATEEEASKLTALRLRLD-ESQKVLLKEREDKLALSRNI-EKLEG-- 285
E E EA+K + +LR E+Q+ D+L ++ + E+L+
Sbjct: 1076 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1135
Query: 286 -----ELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRM---SEDLEDELGARSSMD 337
E+ +W+ + +L + Q +L Q + ++ ++LGR + D LGA
Sbjct: 1136 GERDVEVERWRERVAQLLERWQAVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQDA 1194
Query: 338 RKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRA----------QVGDLEE 387
R+ E M ++ E R+E+ E+ +ER +K+ + D E
Sbjct: 1195 RRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYEL 1252
Query: 388 ALARRRRQ----TASALDCDLRASQAALFEKNKEL----ADLKHVHGKLKKQFQEKVAEL 439
L + Q + A +++ ++ ++ +L ++L + + K E + +
Sbjct: 1253 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312
Query: 440 AHANRRVEQHEAEVKKLRLRVE---ELKKELAQAEDELD-EAHNQARKLQRSLDEQT--- 492
R EQ AE ++ VE E +++LA+A + +A +A++LQ+ + E+
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 493 -EQSENLQVQLEHLQSRLR--RQQQNAPLFGKIRSARFGTEEAEDGTSDLDED 542
E + + Q Q +Q L+ RQ A + K R A E AE ++E+
Sbjct: 1373 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA----EAAERSRLRIEEE 1421
Score = 61.2 bits (147), Expect = 2e-09
Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 52/414 (12%)
Query: 73 EELRLRELEEARAR---AAQMEKTMRRWSD-CTANWREKWSKVRAERNRAREEVRQLRQR 128
E +++++ E AR AAQ +R+ ++ A R K+ E+ +A +E +L+
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2296
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP-EAEREPVRDVG 187
+ L ++ A+ + + Q + E ++LA ++T+ EAER+ ++
Sbjct: 2297 AELLQQQKELAQEQARRLQEDKEQMAQQLA---------EETQGFQRTLEAERQRQLEMS 2347
Query: 188 SERPPGSQELEL-VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATE 246
+E ++ L+L V + ++ ED R +E AT+
Sbjct: 2348 AE----AERLKLRVAEMSRAQARAEEDAQRFRKQA----------EEIGEKLHRTELATQ 2393
Query: 247 EEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLK 306
E+ + + L ++ +S + RE L R EKL+ E ++K EE+ +QE L
Sbjct: 2394 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2453
Query: 307 QLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL-QAENAAEWGRRERLE 365
Q E + + E + +R + + + ++E+L Q E A RE +
Sbjct: 2454 Q----------ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2503
Query: 366 TEKLGLERENKKLRAQVGDLE------EALARRRRQTASALDCDLRASQAALFEKNKELA 419
++ +E+E ++L A + + E RR+++ L+ R + L E+N+ L
Sbjct: 2504 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2563
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ +L+ ++ A LAH+ A K L + L A+AE E
Sbjct: 2564 E------QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2611
Score = 30.4 bits (67), Expect = 4.4
Identities = 60/276 (21%), Positives = 104/276 (37%), Gaps = 13/276 (4%)
Query: 242 TAATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
T EE+ L +L L L +SQ ED+L R Q E+
Sbjct: 884 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 943
Query: 298 SKTKQEMLKQLSILKEAH-QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE--N 354
++ + + +S LK+ Q E L R+ A+ E ++ QAE
Sbjct: 944 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1003
Query: 355 AAEWGRRERLETEK-LGLERENKKLRAQVGDLEEALARRRR-QTASALDCDLRASQAALF 412
+ R E EK L L + +LE L + + ++ SA+ + + + +
Sbjct: 1004 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1063
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
+ ++ H + K+ Q A L +E +A +KKLR + E + D
Sbjct: 1064 RGTQGAEEVLRAHEEQLKEAQAVPATLPE----LEATKASLKKLRAQAEAQQPTFDALRD 1119
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR 508
EL A +LQ+ E+ + E + ++ L R
Sbjct: 1120 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1155
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 96.7 bits (239), Expect = 5e-20
Identities = 132/499 (26%), Positives = 225/499 (45%), Gaps = 63/499 (12%)
Query: 71 SREELRLRELEEARARAAQM--EKTMRRWSDCTANWREKWS------KVRAERNRAREEV 122
+ E RLR L E R Q+ E R+ ++ EK + +++ E A +E
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1996
Query: 123 RQLRQRLDALTKELAGARR--ERQEAQGECEARGRELARLRGARG---------VADQTR 171
+RL L ++ A RR E Q AQ + + R LA+LR A V D R
Sbjct: 1997 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLR 2055
Query: 172 DGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
+ E E ++ + G ELEL ++S E++ E L A R +
Sbjct: 2056 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2115
Query: 232 QERSRLPWED----TAATEEEASK--------LTALRLRLDESQKVLLKEREDKLALSRN 279
+ER R E+ + A EEEA++ + L+ +++E+++ L+ER ++ + +R
Sbjct: 2116 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQES-ARQ 2172
Query: 280 IEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRK 339
++ L E +Q +++ EE + K+ + + Q++ + D+L + R+
Sbjct: 2173 LQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------SVLDQLRGEAEAARR 2225
Query: 340 MAELRGEMERLQAENAAEWGRRERLETEKLGLERENK-KLRAQVGDLEEALARRRRQTAS 398
AE E R+QAE A RR+ E E+L E + + RAQ E L + Q A+
Sbjct: 2226 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284
Query: 399 ALDCDLRASQAALFEKNKELADL-KHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLR 457
+A QAAL +K A++ KH K+F E+ R+ Q E E+ LR
Sbjct: 2285 RR---AQAEQAALRQKQAADAEMEKH------KKFAEQTL------RQKAQVEQELTTLR 2329
Query: 458 LRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEH---LQSRLRRQQQ 514
L++EE + ++EL +A + R + E+ +++VQ+E L++R+ + +
Sbjct: 2330 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2389
Query: 515 NAPLFGKIRSARFGTEEAE 533
L K + RF EEAE
Sbjct: 2390 ALILRDKDNTQRFLQEEAE 2408
Score = 88.2 bits (217), Expect = 2e-17
Identities = 135/555 (24%), Positives = 239/555 (43%), Gaps = 102/555 (18%)
Query: 74 ELRLRELEEARARAAQME-KTMRRWSDCT-----ANWREKWSKVRAERNRAREEVRQLRQ 127
E RLR+ E RAR Q+ +T +R ++ A++ EK +++ V QLR+
Sbjct: 1686 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1745
Query: 128 RLDALTKELAGARRERQEAQGECEA---RGRELARLR-------GARGVADQTRDGPEPE 177
+ ++ A A R R+EA+ E E + E RLR + +A + + E
Sbjct: 1746 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEAR--------SLGAGGPRGSS 229
AERE R G ++ EL E L+ + +E + R L A +G
Sbjct: 1806 AERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1864
Query: 230 GRQ----ERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLK-----EREDKLALSRNI 280
RQ E +RL E AAT++ +L A ++ +VLL E E + ++
Sbjct: 1865 QRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923
Query: 281 EKLEGELSQWKIKYEELSKTK---QEMLKQLSIL-------------------------- 311
++LE E +++ EE ++ + +E +Q +
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983
Query: 312 ------------KEAHQDELGRMSED-------LEDELGA-RSSMDRKMAELR----GEM 347
KEA + L R++ED LE++ ++ ++ ++A+LR E+
Sbjct: 1984 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043
Query: 348 ERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRAS 407
ER + +R ++E E L L+ +K A +LE L R R S + LR+
Sbjct: 2044 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR----SNAEDTLRSK 2099
Query: 408 QAALFEKNKE---LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ A E ++ A+ + + +++ Q+ +A A R+ + EV++L+ +VEE +
Sbjct: 2100 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2159
Query: 465 KELAQAEDE----LDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA-PLF 519
+ +AE E L A A+K R E+ + +Q + + LQ L+++Q L
Sbjct: 2160 RLRERAEQESARQLQLAQEAAQK--RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217
Query: 520 GKIRSARFGTEEAED 534
G+ +AR EEAE+
Sbjct: 2218 GEAEAARRAAEEAEE 2232
Score = 84.7 bits (208), Expect = 2e-16
Identities = 117/510 (22%), Positives = 212/510 (41%), Gaps = 58/510 (11%)
Query: 62 ALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREE 121
+L A+ + + + L E+E +A+ + + R +A + + +R +A E+
Sbjct: 2130 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2189
Query: 122 VRQ--LRQRLDALTKELAGARRERQEAQGECEARGR-----ELARLRGARGVADQTRDGP 174
++Q+ L + L + + +GE EA R E AR++ R A R
Sbjct: 2190 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2249
Query: 175 EPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQER 234
E E ++ + R +Q E L K +E+ +A + + E+
Sbjct: 2250 EAERLKQSAEEQAQAR---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2306
Query: 235 SRLPWEDTAATEEEASK-LTALRLRLDES--QKVLLKEREDKLAL-----SRNIEKLEGE 286
+ E T + + + LT LRL+L+E+ QK LL E +L +R ++E E
Sbjct: 2307 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366
Query: 287 LSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGE 346
L +++ EELSK K + + L +D R L++E KM ++ E
Sbjct: 2367 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF---LQEEA-------EKMKQVAEE 2416
Query: 347 MERLQAENAAEWGRRERLETEKLGLERE--NKKLRAQVGDLEEALARRRRQTASALDCDL 404
RL A E R +L E L +R K L+ ++ ++EA + +L
Sbjct: 2417 AARLSVA-AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2475
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
QA +++KE + +L ++ Q L +R + AE ++L+LRV E+
Sbjct: 2476 AQEQARRLQEDKE-----QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2530
Query: 465 KELAQAEDELDEAHNQARK-----------------LQRSLDEQTEQS----ENLQVQLE 503
+ A+AE++ QA + L ++L+ Q +QS E L+ +
Sbjct: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2590
Query: 504 HLQSRLRRQQQNAPLFGKIRSARFGTEEAE 533
L+ + QQ A L +++S T + E
Sbjct: 2591 ELEREKEKLQQEAKLL-QLKSEEMQTVQQE 2619
Score = 77.0 bits (188), Expect = 4e-14
Identities = 111/459 (24%), Positives = 196/459 (42%), Gaps = 27/459 (5%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANW---REKWSKVRAERNRAREEVRQLR 126
E+ E RLR EE R Q+E T R+ R + + A++ +A+EE +LR
Sbjct: 1578 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1637
Query: 127 QRLDALTK-----ELAGARRERQEAQGECEARGRELARLRGARGVADQT-RDGPEPEAER 180
+++ ++ E+ A R + EA+ E + R L L R A++ R + E ER
Sbjct: 1638 RQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVER 1696
Query: 181 EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE---RSRL 237
V E S E EL +S S E++ RSL + R+E R++
Sbjct: 1697 ARQVQVALETAQRSAEAEL-QSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQ 1753
Query: 238 PWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
E A EE +L +L+ +E+ ++ L+ E +A +++ + E E + + + E
Sbjct: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREAR 1811
Query: 298 SKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAE 357
+ K E + Q EL + + +L ++ R AE E+ RL+AE
Sbjct: 1812 RRGKAEE-------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQG 1862
Query: 358 WGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKE 417
+R+ LE E L+RE + +LE LA+ R + L RA + + K
Sbjct: 1863 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 418 LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEA 477
L+ G+ ++ +E A A Q + + + E ++ LA+ + EA
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1982
Query: 478 HNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA 516
+ + +L E+ ++E L+ E + RR ++ A
Sbjct: 1983 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Score = 73.6 bits (179), Expect = 5e-13
Identities = 113/498 (22%), Positives = 212/498 (42%), Gaps = 53/498 (10%)
Query: 72 REELR-LREL-EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQL---- 125
R+ELR +E+ E + R + + + RW + A E+W V A+ + + E+ QL
Sbjct: 1287 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1346
Query: 126 ---RQRLDALTKELAGARRERQEAQGECEARGREL-ARLRGARGVADQTRDGPE--PEAE 179
R+ D L L ARR +++ Q A + + +LR + + ++ E E +
Sbjct: 1347 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1406
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
R + + + + EL+LV + P S A P+ SG E +
Sbjct: 1407 RFAKQYINAIK---DYELQLVTYKAQLEPVASP---------AKKPKVQSG-SESVIQEY 1453
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIE------KLEGELSQWKIK 293
D E + LT+ ++ S+ + E E++LA + E ++E L + +
Sbjct: 1454 VDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512
Query: 294 YEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE 353
E ++ K + ++ L++ Q+E+ R E D + S+ ++ +LR E AE
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AE 1569
Query: 354 NAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFE 413
A+ + E E +L +E E + +R Q+ EA R+R + +L+A +A E
Sbjct: 1570 IQAKARQAEAAERSRLRIEEEIRVVRLQL----EATERQR----GGAEGELQALRARAEE 1621
Query: 414 KNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ + +L++Q Q++ ++R Q E E+ E +E +A
Sbjct: 1622 AEAQKRQAQEEAERLRRQVQDE-------SQRKRQAEVELASRVKAEAEAAREKQRALQA 1674
Query: 474 LDEAHNQARKLQRSLDE-QTEQSENLQVQLEHLQ--SRLRRQQQNAPLFGKIRSARFGTE 530
L+E QA + +R L + + E++ +QV LE Q + Q + A K +
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734
Query: 531 EAEDGTSDLDEDEDLQIQ 548
E + L E+ + + Q
Sbjct: 1735 EEHVAVAQLREEAERRAQ 1752
Score = 68.2 bits (165), Expect = 2e-11
Identities = 110/497 (22%), Positives = 217/497 (43%), Gaps = 85/497 (17%)
Query: 73 EELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ-------- 124
E+LR +E E+ AR AQ E+ R EK K + R + +V Q
Sbjct: 2273 EKLR-KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2331
Query: 125 ----------LRQRLDALTKELAGARRERQEAQGEC---EARGRELARLRG---ARGVA- 167
L + L L E A R+R + + E + EL++L+ A A
Sbjct: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391
Query: 168 -----DQTRDGPEPEAER-EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLG 221
D T+ + EAE+ + V + + +QE + L + ED + R+L
Sbjct: 2392 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALA 2445
Query: 222 AGGPRGS-SGRQERSRLPWE-DTAATEEEASKLTALRLRLDESQ-------------KVL 266
+ QE +RL E + ++E ++ A RL+ D+ Q + L
Sbjct: 2446 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2505
Query: 267 LKEREDKLALSRNIEKLE---GELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMS 323
ER+ +L +S E+L+ E+S+ + + EE ++ ++ +++ ++ H+ EL
Sbjct: 2506 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHRTEL---- 2559
Query: 324 EDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE--RLETEKLGLERENKKLRAQ 381
++ ++ E++R Q+++ AE R LE EK L++E K L+ +
Sbjct: 2560 ----------ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2609
Query: 382 VGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAH 441
+++ + Q AL + + +L ++ + + K KL++ FQ++VA+
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK---AKLEQLFQDEVAKAQQ 2666
Query: 442 AN----RRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ----TE 493
R+ +Q E E ++L +EE ++ +AE+ + + ++L++ +Q E
Sbjct: 2667 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2726
Query: 494 QSENLQVQLEHLQSRLR 510
+++ L+ QL+ L+ + R
Sbjct: 2727 ENQRLREQLQLLEEQHR 2743
Score = 63.5 bits (153), Expect = 5e-10
Identities = 122/533 (22%), Positives = 223/533 (41%), Gaps = 76/533 (14%)
Query: 59 PAPALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRA 118
P L+A+ ++ S ++L ++ + AQ E +R C + ++ ++ A R
Sbjct: 1085 PEDRLMAEREYGSCSH-HYQQLLQSLEQGAQEESRCQR---CISELKDIRLQLEACETRT 1140
Query: 119 REEVRQLRQRLDAL-TKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPE 177
V +LR LD +E A E+Q+AQ E E G+ +ARL A++ PEP
Sbjct: 1141 ---VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPS 1194
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRL 237
+R ELEL L+ + S E + RG+ G +E R
Sbjct: 1195 PAAPTLR----------SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1244
Query: 238 PWED--------TAATEEEASKLTALRLRLD-ESQKVLLKEREDKLALSRNI-EKLEG-- 285
E E EA+K + +LR E+Q+ D+L ++ + E+L+
Sbjct: 1245 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1304
Query: 286 -----ELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRM---SEDLEDELGARSSMD 337
E+ +W+ + +L + Q +L Q + ++ ++LGR + D LGA
Sbjct: 1305 GERDVEVERWRERVAQLLERWQAVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQDA 1363
Query: 338 RKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRA----------QVGDLEE 387
R+ E M ++ E R+E+ E+ +ER +K+ + D E
Sbjct: 1364 RRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYEL 1421
Query: 388 ALARRRRQ----TASALDCDLRASQAALFEKNKEL----ADLKHVHGKLKKQFQEKVAEL 439
L + Q + A +++ ++ ++ +L ++L + + K E + +
Sbjct: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481
Query: 440 AHANRRVEQHEAEVKKLRLRVE---ELKKELAQAEDELD-EAHNQARKLQRSLDEQT--- 492
R EQ AE ++ VE E +++LA+A + +A +A++LQ+ + E+
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 493 -EQSENLQVQLEHLQSRLR--RQQQNAPLFGKIRSARFGTEEAEDGTSDLDED 542
E + + Q Q +Q L+ RQ A + K R A E AE ++E+
Sbjct: 1542 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA----EAAERSRLRIEEE 1590
Score = 61.2 bits (147), Expect = 2e-09
Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 52/414 (12%)
Query: 73 EELRLRELEEARAR---AAQMEKTMRRWSD-CTANWREKWSKVRAERNRAREEVRQLRQR 128
E +++++ E AR AAQ +R+ ++ A R K+ E+ +A +E +L+
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2465
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP-EAEREPVRDVG 187
+ L ++ A+ + + Q + E ++LA ++T+ EAER+ ++
Sbjct: 2466 AELLQQQKELAQEQARRLQEDKEQMAQQLA---------EETQGFQRTLEAERQRQLEMS 2516
Query: 188 SERPPGSQELEL-VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATE 246
+E ++ L+L V + ++ ED R +E AT+
Sbjct: 2517 AE----AERLKLRVAEMSRAQARAEEDAQRFRKQA----------EEIGEKLHRTELATQ 2562
Query: 247 EEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLK 306
E+ + + L ++ +S + RE L R EKL+ E ++K EE+ +QE L
Sbjct: 2563 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2622
Query: 307 QLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL-QAENAAEWGRRERLE 365
Q E + + E + +R + + + ++E+L Q E A RE +
Sbjct: 2623 Q----------ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2672
Query: 366 TEKLGLERENKKLRAQVGDLE------EALARRRRQTASALDCDLRASQAALFEKNKELA 419
++ +E+E ++L A + + E RR+++ L+ R + L E+N+ L
Sbjct: 2673 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2732
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ +L+ ++ A LAH+ A K L + L A+AE E
Sbjct: 2733 E------QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2780
Score = 30.4 bits (67), Expect = 4.4
Identities = 60/276 (21%), Positives = 104/276 (37%), Gaps = 13/276 (4%)
Query: 242 TAATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
T EE+ L +L L L +SQ ED+L R Q E+
Sbjct: 1053 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1112
Query: 298 SKTKQEMLKQLSILKEAH-QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE--N 354
++ + + +S LK+ Q E L R+ A+ E ++ QAE
Sbjct: 1113 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1172
Query: 355 AAEWGRRERLETEK-LGLERENKKLRAQVGDLEEALARRRR-QTASALDCDLRASQAALF 412
+ R E EK L L + +LE L + + ++ SA+ + + + +
Sbjct: 1173 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1232
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
+ ++ H + K+ Q A L +E +A +KKLR + E + D
Sbjct: 1233 RGTQGAEEVLRAHEEQLKEAQAVPATLPE----LEATKASLKKLRAQAEAQQPTFDALRD 1288
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR 508
EL A +LQ+ E+ + E + ++ L R
Sbjct: 1289 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 96.7 bits (239), Expect = 5e-20
Identities = 132/499 (26%), Positives = 225/499 (45%), Gaps = 63/499 (12%)
Query: 71 SREELRLRELEEARARAAQM--EKTMRRWSDCTANWREKWS------KVRAERNRAREEV 122
+ E RLR L E R Q+ E R+ ++ EK + +++ E A +E
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1837
Query: 123 RQLRQRLDALTKELAGARR--ERQEAQGECEARGRELARLRGARG---------VADQTR 171
+RL L ++ A RR E Q AQ + + R LA+LR A V D R
Sbjct: 1838 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLR 1896
Query: 172 DGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
+ E E ++ + G ELEL ++S E++ E L A R +
Sbjct: 1897 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1956
Query: 232 QERSRLPWED----TAATEEEASK--------LTALRLRLDESQKVLLKEREDKLALSRN 279
+ER R E+ + A EEEA++ + L+ +++E+++ L+ER ++ + +R
Sbjct: 1957 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQES-ARQ 2013
Query: 280 IEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRK 339
++ L E +Q +++ EE + K+ + + Q++ + D+L + R+
Sbjct: 2014 LQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------SVLDQLRGEAEAARR 2066
Query: 340 MAELRGEMERLQAENAAEWGRRERLETEKLGLERENK-KLRAQVGDLEEALARRRRQTAS 398
AE E R+QAE A RR+ E E+L E + + RAQ E L + Q A+
Sbjct: 2067 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125
Query: 399 ALDCDLRASQAALFEKNKELADL-KHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLR 457
+A QAAL +K A++ KH K+F E+ R+ Q E E+ LR
Sbjct: 2126 RR---AQAEQAALRQKQAADAEMEKH------KKFAEQTL------RQKAQVEQELTTLR 2170
Query: 458 LRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEH---LQSRLRRQQQ 514
L++EE + ++EL +A + R + E+ +++VQ+E L++R+ + +
Sbjct: 2171 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2230
Query: 515 NAPLFGKIRSARFGTEEAE 533
L K + RF EEAE
Sbjct: 2231 ALILRDKDNTQRFLQEEAE 2249
Score = 88.2 bits (217), Expect = 2e-17
Identities = 135/555 (24%), Positives = 239/555 (43%), Gaps = 102/555 (18%)
Query: 74 ELRLRELEEARARAAQME-KTMRRWSDCT-----ANWREKWSKVRAERNRAREEVRQLRQ 127
E RLR+ E RAR Q+ +T +R ++ A++ EK +++ V QLR+
Sbjct: 1527 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1586
Query: 128 RLDALTKELAGARRERQEAQGECEA---RGRELARLR-------GARGVADQTRDGPEPE 177
+ ++ A A R R+EA+ E E + E RLR + +A + + E
Sbjct: 1587 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEAR--------SLGAGGPRGSS 229
AERE R G ++ EL E L+ + +E + R L A +G
Sbjct: 1647 AERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1705
Query: 230 GRQ----ERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLK-----EREDKLALSRNI 280
RQ E +RL E AAT++ +L A ++ +VLL E E + ++
Sbjct: 1706 QRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764
Query: 281 EKLEGELSQWKIKYEELSKTK---QEMLKQLSIL-------------------------- 311
++LE E +++ EE ++ + +E +Q +
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824
Query: 312 ------------KEAHQDELGRMSED-------LEDELGA-RSSMDRKMAELR----GEM 347
KEA + L R++ED LE++ ++ ++ ++A+LR E+
Sbjct: 1825 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1884
Query: 348 ERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRAS 407
ER + +R ++E E L L+ +K A +LE L R R S + LR+
Sbjct: 1885 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR----SNAEDTLRSK 1940
Query: 408 QAALFEKNKE---LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ A E ++ A+ + + +++ Q+ +A A R+ + EV++L+ +VEE +
Sbjct: 1941 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2000
Query: 465 KELAQAEDE----LDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA-PLF 519
+ +AE E L A A+K R E+ + +Q + + LQ L+++Q L
Sbjct: 2001 RLRERAEQESARQLQLAQEAAQK--RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058
Query: 520 GKIRSARFGTEEAED 534
G+ +AR EEAE+
Sbjct: 2059 GEAEAARRAAEEAEE 2073
Score = 84.7 bits (208), Expect = 2e-16
Identities = 117/510 (22%), Positives = 212/510 (41%), Gaps = 58/510 (11%)
Query: 62 ALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREE 121
+L A+ + + + L E+E +A+ + + R +A + + +R +A E+
Sbjct: 1971 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2030
Query: 122 VRQ--LRQRLDALTKELAGARRERQEAQGECEARGR-----ELARLRGARGVADQTRDGP 174
++Q+ L + L + + +GE EA R E AR++ R A R
Sbjct: 2031 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2090
Query: 175 EPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQER 234
E E ++ + R +Q E L K +E+ +A + + E+
Sbjct: 2091 EAERLKQSAEEQAQAR---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2147
Query: 235 SRLPWEDTAATEEEASK-LTALRLRLDES--QKVLLKEREDKLAL-----SRNIEKLEGE 286
+ E T + + + LT LRL+L+E+ QK LL E +L +R ++E E
Sbjct: 2148 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207
Query: 287 LSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGE 346
L +++ EELSK K + + L +D R L++E KM ++ E
Sbjct: 2208 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF---LQEEA-------EKMKQVAEE 2257
Query: 347 MERLQAENAAEWGRRERLETEKLGLERE--NKKLRAQVGDLEEALARRRRQTASALDCDL 404
RL A E R +L E L +R K L+ ++ ++EA + +L
Sbjct: 2258 AARLSVA-AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2316
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
QA +++KE + +L ++ Q L +R + AE ++L+LRV E+
Sbjct: 2317 AQEQARRLQEDKE-----QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2371
Query: 465 KELAQAEDELDEAHNQARK-----------------LQRSLDEQTEQS----ENLQVQLE 503
+ A+AE++ QA + L ++L+ Q +QS E L+ +
Sbjct: 2372 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2431
Query: 504 HLQSRLRRQQQNAPLFGKIRSARFGTEEAE 533
L+ + QQ A L +++S T + E
Sbjct: 2432 ELEREKEKLQQEAKLL-QLKSEEMQTVQQE 2460
Score = 77.0 bits (188), Expect = 4e-14
Identities = 111/459 (24%), Positives = 196/459 (42%), Gaps = 27/459 (5%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANW---REKWSKVRAERNRAREEVRQLR 126
E+ E RLR EE R Q+E T R+ R + + A++ +A+EE +LR
Sbjct: 1419 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1478
Query: 127 QRLDALTK-----ELAGARRERQEAQGECEARGRELARLRGARGVADQT-RDGPEPEAER 180
+++ ++ E+ A R + EA+ E + R L L R A++ R + E ER
Sbjct: 1479 RQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVER 1537
Query: 181 EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE---RSRL 237
V E S E EL +S S E++ RSL + R+E R++
Sbjct: 1538 ARQVQVALETAQRSAEAEL-QSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQ 1594
Query: 238 PWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
E A EE +L +L+ +E+ ++ L+ E +A +++ + E E + + + E
Sbjct: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREAR 1652
Query: 298 SKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAE 357
+ K E + Q EL + + +L ++ R AE E+ RL+AE
Sbjct: 1653 RRGKAEE-------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQG 1703
Query: 358 WGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKE 417
+R+ LE E L+RE + +LE LA+ R + L RA + + K
Sbjct: 1704 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763
Query: 418 LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEA 477
L+ G+ ++ +E A A Q + + + E ++ LA+ + EA
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1823
Query: 478 HNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA 516
+ + +L E+ ++E L+ E + RR ++ A
Sbjct: 1824 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862
Score = 73.6 bits (179), Expect = 5e-13
Identities = 113/498 (22%), Positives = 212/498 (42%), Gaps = 53/498 (10%)
Query: 72 REELR-LREL-EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQL---- 125
R+ELR +E+ E + R + + + RW + A E+W V A+ + + E+ QL
Sbjct: 1128 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1187
Query: 126 ---RQRLDALTKELAGARRERQEAQGECEARGREL-ARLRGARGVADQTRDGPE--PEAE 179
R+ D L L ARR +++ Q A + + +LR + + ++ E E +
Sbjct: 1188 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1247
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
R + + + + EL+LV + P S A P+ SG E +
Sbjct: 1248 RFAKQYINAIK---DYELQLVTYKAQLEPVASP---------AKKPKVQSG-SESVIQEY 1294
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIE------KLEGELSQWKIK 293
D E + LT+ ++ S+ + E E++LA + E ++E L + +
Sbjct: 1295 VDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1353
Query: 294 YEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE 353
E ++ K + ++ L++ Q+E+ R E D + S+ ++ +LR E AE
Sbjct: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AE 1410
Query: 354 NAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFE 413
A+ + E E +L +E E + +R Q+ EA R+R + +L+A +A E
Sbjct: 1411 IQAKARQAEAAERSRLRIEEEIRVVRLQL----EATERQR----GGAEGELQALRARAEE 1462
Query: 414 KNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ + +L++Q Q++ ++R Q E E+ E +E +A
Sbjct: 1463 AEAQKRQAQEEAERLRRQVQDE-------SQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
Query: 474 LDEAHNQARKLQRSLDE-QTEQSENLQVQLEHLQ--SRLRRQQQNAPLFGKIRSARFGTE 530
L+E QA + +R L + + E++ +QV LE Q + Q + A K +
Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
Query: 531 EAEDGTSDLDEDEDLQIQ 548
E + L E+ + + Q
Sbjct: 1576 EEHVAVAQLREEAERRAQ 1593
Score = 68.2 bits (165), Expect = 2e-11
Identities = 110/497 (22%), Positives = 217/497 (43%), Gaps = 85/497 (17%)
Query: 73 EELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ-------- 124
E+LR +E E+ AR AQ E+ R EK K + R + +V Q
Sbjct: 2114 EKLR-KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2172
Query: 125 ----------LRQRLDALTKELAGARRERQEAQGEC---EARGRELARLRG---ARGVA- 167
L + L L E A R+R + + E + EL++L+ A A
Sbjct: 2173 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232
Query: 168 -----DQTRDGPEPEAER-EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLG 221
D T+ + EAE+ + V + + +QE + L + ED + R+L
Sbjct: 2233 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALA 2286
Query: 222 AGGPRGS-SGRQERSRLPWE-DTAATEEEASKLTALRLRLDESQ-------------KVL 266
+ QE +RL E + ++E ++ A RL+ D+ Q + L
Sbjct: 2287 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2346
Query: 267 LKEREDKLALSRNIEKLE---GELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMS 323
ER+ +L +S E+L+ E+S+ + + EE ++ ++ +++ ++ H+ EL
Sbjct: 2347 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHRTEL---- 2400
Query: 324 EDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE--RLETEKLGLERENKKLRAQ 381
++ ++ E++R Q+++ AE R LE EK L++E K L+ +
Sbjct: 2401 ----------ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2450
Query: 382 VGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAH 441
+++ + Q AL + + +L ++ + + K KL++ FQ++VA+
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK---AKLEQLFQDEVAKAQQ 2507
Query: 442 AN----RRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ----TE 493
R+ +Q E E ++L +EE ++ +AE+ + + ++L++ +Q E
Sbjct: 2508 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2567
Query: 494 QSENLQVQLEHLQSRLR 510
+++ L+ QL+ L+ + R
Sbjct: 2568 ENQRLREQLQLLEEQHR 2584
Score = 63.5 bits (153), Expect = 5e-10
Identities = 122/533 (22%), Positives = 223/533 (41%), Gaps = 76/533 (14%)
Query: 59 PAPALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRA 118
P L+A+ ++ S ++L ++ + AQ E +R C + ++ ++ A R
Sbjct: 926 PEDRLMAEREYGSCSH-HYQQLLQSLEQGAQEESRCQR---CISELKDIRLQLEACETRT 981
Query: 119 REEVRQLRQRLDAL-TKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPE 177
V +LR LD +E A E+Q+AQ E E G+ +ARL A++ PEP
Sbjct: 982 ---VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPS 1035
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRL 237
+R ELEL L+ + S E + RG+ G +E R
Sbjct: 1036 PAAPTLR----------SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1085
Query: 238 PWED--------TAATEEEASKLTALRLRLD-ESQKVLLKEREDKLALSRNI-EKLEG-- 285
E E EA+K + +LR E+Q+ D+L ++ + E+L+
Sbjct: 1086 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1145
Query: 286 -----ELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRM---SEDLEDELGARSSMD 337
E+ +W+ + +L + Q +L Q + ++ ++LGR + D LGA
Sbjct: 1146 GERDVEVERWRERVAQLLERWQAVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQDA 1204
Query: 338 RKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRA----------QVGDLEE 387
R+ E M ++ E R+E+ E+ +ER +K+ + D E
Sbjct: 1205 RRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYEL 1262
Query: 388 ALARRRRQ----TASALDCDLRASQAALFEKNKEL----ADLKHVHGKLKKQFQEKVAEL 439
L + Q + A +++ ++ ++ +L ++L + + K E + +
Sbjct: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322
Query: 440 AHANRRVEQHEAEVKKLRLRVE---ELKKELAQAEDELD-EAHNQARKLQRSLDEQT--- 492
R EQ AE ++ VE E +++LA+A + +A +A++LQ+ + E+
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 493 -EQSENLQVQLEHLQSRLR--RQQQNAPLFGKIRSARFGTEEAEDGTSDLDED 542
E + + Q Q +Q L+ RQ A + K R A E AE ++E+
Sbjct: 1383 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA----EAAERSRLRIEEE 1431
Score = 61.2 bits (147), Expect = 2e-09
Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 52/414 (12%)
Query: 73 EELRLRELEEARAR---AAQMEKTMRRWSD-CTANWREKWSKVRAERNRAREEVRQLRQR 128
E +++++ E AR AAQ +R+ ++ A R K+ E+ +A +E +L+
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2306
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP-EAEREPVRDVG 187
+ L ++ A+ + + Q + E ++LA ++T+ EAER+ ++
Sbjct: 2307 AELLQQQKELAQEQARRLQEDKEQMAQQLA---------EETQGFQRTLEAERQRQLEMS 2357
Query: 188 SERPPGSQELEL-VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATE 246
+E ++ L+L V + ++ ED R +E AT+
Sbjct: 2358 AE----AERLKLRVAEMSRAQARAEEDAQRFRKQA----------EEIGEKLHRTELATQ 2403
Query: 247 EEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLK 306
E+ + + L ++ +S + RE L R EKL+ E ++K EE+ +QE L
Sbjct: 2404 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2463
Query: 307 QLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL-QAENAAEWGRRERLE 365
Q E + + E + +R + + + ++E+L Q E A RE +
Sbjct: 2464 Q----------ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2513
Query: 366 TEKLGLERENKKLRAQVGDLE------EALARRRRQTASALDCDLRASQAALFEKNKELA 419
++ +E+E ++L A + + E RR+++ L+ R + L E+N+ L
Sbjct: 2514 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2573
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ +L+ ++ A LAH+ A K L + L A+AE E
Sbjct: 2574 E------QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2621
Score = 30.4 bits (67), Expect = 4.4
Identities = 60/276 (21%), Positives = 104/276 (37%), Gaps = 13/276 (4%)
Query: 242 TAATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
T EE+ L +L L L +SQ ED+L R Q E+
Sbjct: 894 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 953
Query: 298 SKTKQEMLKQLSILKEAH-QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE--N 354
++ + + +S LK+ Q E L R+ A+ E ++ QAE
Sbjct: 954 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1013
Query: 355 AAEWGRRERLETEK-LGLERENKKLRAQVGDLEEALARRRR-QTASALDCDLRASQAALF 412
+ R E EK L L + +LE L + + ++ SA+ + + + +
Sbjct: 1014 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1073
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
+ ++ H + K+ Q A L +E +A +KKLR + E + D
Sbjct: 1074 RGTQGAEEVLRAHEEQLKEAQAVPATLPE----LEATKASLKKLRAQAEAQQPTFDALRD 1129
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR 508
EL A +LQ+ E+ + E + ++ L R
Sbjct: 1130 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 96.7 bits (239), Expect = 5e-20
Identities = 132/499 (26%), Positives = 225/499 (45%), Gaps = 63/499 (12%)
Query: 71 SREELRLRELEEARARAAQM--EKTMRRWSDCTANWREKWS------KVRAERNRAREEV 122
+ E RLR L E R Q+ E R+ ++ EK + +++ E A +E
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1845
Query: 123 RQLRQRLDALTKELAGARR--ERQEAQGECEARGRELARLRGARG---------VADQTR 171
+RL L ++ A RR E Q AQ + + R LA+LR A V D R
Sbjct: 1846 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLR 1904
Query: 172 DGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
+ E E ++ + G ELEL ++S E++ E L A R +
Sbjct: 1905 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 1964
Query: 232 QERSRLPWED----TAATEEEASK--------LTALRLRLDESQKVLLKEREDKLALSRN 279
+ER R E+ + A EEEA++ + L+ +++E+++ L+ER ++ + +R
Sbjct: 1965 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQES-ARQ 2021
Query: 280 IEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRK 339
++ L E +Q +++ EE + K+ + + Q++ + D+L + R+
Sbjct: 2022 LQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------SVLDQLRGEAEAARR 2074
Query: 340 MAELRGEMERLQAENAAEWGRRERLETEKLGLERENK-KLRAQVGDLEEALARRRRQTAS 398
AE E R+QAE A RR+ E E+L E + + RAQ E L + Q A+
Sbjct: 2075 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133
Query: 399 ALDCDLRASQAALFEKNKELADL-KHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLR 457
+A QAAL +K A++ KH K+F E+ R+ Q E E+ LR
Sbjct: 2134 RR---AQAEQAALRQKQAADAEMEKH------KKFAEQTL------RQKAQVEQELTTLR 2178
Query: 458 LRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEH---LQSRLRRQQQ 514
L++EE + ++EL +A + R + E+ +++VQ+E L++R+ + +
Sbjct: 2179 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2238
Query: 515 NAPLFGKIRSARFGTEEAE 533
L K + RF EEAE
Sbjct: 2239 ALILRDKDNTQRFLQEEAE 2257
Score = 88.2 bits (217), Expect = 2e-17
Identities = 135/555 (24%), Positives = 239/555 (43%), Gaps = 102/555 (18%)
Query: 74 ELRLRELEEARARAAQME-KTMRRWSDCT-----ANWREKWSKVRAERNRAREEVRQLRQ 127
E RLR+ E RAR Q+ +T +R ++ A++ EK +++ V QLR+
Sbjct: 1535 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1594
Query: 128 RLDALTKELAGARRERQEAQGECEA---RGRELARLR-------GARGVADQTRDGPEPE 177
+ ++ A A R R+EA+ E E + E RLR + +A + + E
Sbjct: 1595 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1654
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEAR--------SLGAGGPRGSS 229
AERE R G ++ EL E L+ + +E + R L A +G
Sbjct: 1655 AERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1713
Query: 230 GRQ----ERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLK-----EREDKLALSRNI 280
RQ E +RL E AAT++ +L A ++ +VLL E E + ++
Sbjct: 1714 QRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1772
Query: 281 EKLEGELSQWKIKYEELSKTK---QEMLKQLSIL-------------------------- 311
++LE E +++ EE ++ + +E +Q +
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1832
Query: 312 ------------KEAHQDELGRMSED-------LEDELGA-RSSMDRKMAELR----GEM 347
KEA + L R++ED LE++ ++ ++ ++A+LR E+
Sbjct: 1833 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1892
Query: 348 ERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRAS 407
ER + +R ++E E L L+ +K A +LE L R R S + LR+
Sbjct: 1893 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR----SNAEDTLRSK 1948
Query: 408 QAALFEKNKE---LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ A E ++ A+ + + +++ Q+ +A A R+ + EV++L+ +VEE +
Sbjct: 1949 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2008
Query: 465 KELAQAEDE----LDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA-PLF 519
+ +AE E L A A+K R E+ + +Q + + LQ L+++Q L
Sbjct: 2009 RLRERAEQESARQLQLAQEAAQK--RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066
Query: 520 GKIRSARFGTEEAED 534
G+ +AR EEAE+
Sbjct: 2067 GEAEAARRAAEEAEE 2081
Score = 84.7 bits (208), Expect = 2e-16
Identities = 117/510 (22%), Positives = 212/510 (41%), Gaps = 58/510 (11%)
Query: 62 ALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREE 121
+L A+ + + + L E+E +A+ + + R +A + + +R +A E+
Sbjct: 1979 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2038
Query: 122 VRQ--LRQRLDALTKELAGARRERQEAQGECEARGR-----ELARLRGARGVADQTRDGP 174
++Q+ L + L + + +GE EA R E AR++ R A R
Sbjct: 2039 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2098
Query: 175 EPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQER 234
E E ++ + R +Q E L K +E+ +A + + E+
Sbjct: 2099 EAERLKQSAEEQAQAR---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2155
Query: 235 SRLPWEDTAATEEEASK-LTALRLRLDES--QKVLLKEREDKLAL-----SRNIEKLEGE 286
+ E T + + + LT LRL+L+E+ QK LL E +L +R ++E E
Sbjct: 2156 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2215
Query: 287 LSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGE 346
L +++ EELSK K + + L +D R L++E KM ++ E
Sbjct: 2216 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF---LQEEA-------EKMKQVAEE 2265
Query: 347 MERLQAENAAEWGRRERLETEKLGLERE--NKKLRAQVGDLEEALARRRRQTASALDCDL 404
RL A E R +L E L +R K L+ ++ ++EA + +L
Sbjct: 2266 AARLSVA-AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2324
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
QA +++KE + +L ++ Q L +R + AE ++L+LRV E+
Sbjct: 2325 AQEQARRLQEDKE-----QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2379
Query: 465 KELAQAEDELDEAHNQARK-----------------LQRSLDEQTEQS----ENLQVQLE 503
+ A+AE++ QA + L ++L+ Q +QS E L+ +
Sbjct: 2380 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2439
Query: 504 HLQSRLRRQQQNAPLFGKIRSARFGTEEAE 533
L+ + QQ A L +++S T + E
Sbjct: 2440 ELEREKEKLQQEAKLL-QLKSEEMQTVQQE 2468
Score = 77.0 bits (188), Expect = 4e-14
Identities = 111/459 (24%), Positives = 196/459 (42%), Gaps = 27/459 (5%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANW---REKWSKVRAERNRAREEVRQLR 126
E+ E RLR EE R Q+E T R+ R + + A++ +A+EE +LR
Sbjct: 1427 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1486
Query: 127 QRLDALTK-----ELAGARRERQEAQGECEARGRELARLRGARGVADQT-RDGPEPEAER 180
+++ ++ E+ A R + EA+ E + R L L R A++ R + E ER
Sbjct: 1487 RQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVER 1545
Query: 181 EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE---RSRL 237
V E S E EL +S S E++ RSL + R+E R++
Sbjct: 1546 ARQVQVALETAQRSAEAEL-QSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQ 1602
Query: 238 PWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
E A EE +L +L+ +E+ ++ L+ E +A +++ + E E + + + E
Sbjct: 1603 QAEAERAREEAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREAR 1660
Query: 298 SKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAE 357
+ K E + Q EL + + +L ++ R AE E+ RL+AE
Sbjct: 1661 RRGKAEE-------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQG 1711
Query: 358 WGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKE 417
+R+ LE E L+RE + +LE LA+ R + L RA + + K
Sbjct: 1712 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1771
Query: 418 LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEA 477
L+ G+ ++ +E A A Q + + + E ++ LA+ + EA
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1831
Query: 478 HNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA 516
+ + +L E+ ++E L+ E + RR ++ A
Sbjct: 1832 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870
Score = 73.6 bits (179), Expect = 5e-13
Identities = 113/498 (22%), Positives = 212/498 (42%), Gaps = 53/498 (10%)
Query: 72 REELR-LREL-EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQL---- 125
R+ELR +E+ E + R + + + RW + A E+W V A+ + + E+ QL
Sbjct: 1136 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1195
Query: 126 ---RQRLDALTKELAGARRERQEAQGECEARGREL-ARLRGARGVADQTRDGPE--PEAE 179
R+ D L L ARR +++ Q A + + +LR + + ++ E E +
Sbjct: 1196 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1255
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
R + + + + EL+LV + P S A P+ SG E +
Sbjct: 1256 RFAKQYINAIK---DYELQLVTYKAQLEPVASP---------AKKPKVQSG-SESVIQEY 1302
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIE------KLEGELSQWKIK 293
D E + LT+ ++ S+ + E E++LA + E ++E L + +
Sbjct: 1303 VDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1361
Query: 294 YEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE 353
E ++ K + ++ L++ Q+E+ R E D + S+ ++ +LR E AE
Sbjct: 1362 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AE 1418
Query: 354 NAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFE 413
A+ + E E +L +E E + +R Q+ EA R+R + +L+A +A E
Sbjct: 1419 IQAKARQAEAAERSRLRIEEEIRVVRLQL----EATERQR----GGAEGELQALRARAEE 1470
Query: 414 KNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ + +L++Q Q++ ++R Q E E+ E +E +A
Sbjct: 1471 AEAQKRQAQEEAERLRRQVQDE-------SQRKRQAEVELASRVKAEAEAAREKQRALQA 1523
Query: 474 LDEAHNQARKLQRSLDE-QTEQSENLQVQLEHLQ--SRLRRQQQNAPLFGKIRSARFGTE 530
L+E QA + +R L + + E++ +QV LE Q + Q + A K +
Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1583
Query: 531 EAEDGTSDLDEDEDLQIQ 548
E + L E+ + + Q
Sbjct: 1584 EEHVAVAQLREEAERRAQ 1601
Score = 68.2 bits (165), Expect = 2e-11
Identities = 110/497 (22%), Positives = 217/497 (43%), Gaps = 85/497 (17%)
Query: 73 EELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ-------- 124
E+LR +E E+ AR AQ E+ R EK K + R + +V Q
Sbjct: 2122 EKLR-KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2180
Query: 125 ----------LRQRLDALTKELAGARRERQEAQGEC---EARGRELARLRG---ARGVA- 167
L + L L E A R+R + + E + EL++L+ A A
Sbjct: 2181 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2240
Query: 168 -----DQTRDGPEPEAER-EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLG 221
D T+ + EAE+ + V + + +QE + L + ED + R+L
Sbjct: 2241 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALA 2294
Query: 222 AGGPRGS-SGRQERSRLPWE-DTAATEEEASKLTALRLRLDESQ-------------KVL 266
+ QE +RL E + ++E ++ A RL+ D+ Q + L
Sbjct: 2295 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2354
Query: 267 LKEREDKLALSRNIEKLE---GELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMS 323
ER+ +L +S E+L+ E+S+ + + EE ++ ++ +++ ++ H+ EL
Sbjct: 2355 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHRTEL---- 2408
Query: 324 EDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE--RLETEKLGLERENKKLRAQ 381
++ ++ E++R Q+++ AE R LE EK L++E K L+ +
Sbjct: 2409 ----------ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2458
Query: 382 VGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAH 441
+++ + Q AL + + +L ++ + + K KL++ FQ++VA+
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK---AKLEQLFQDEVAKAQQ 2515
Query: 442 AN----RRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ----TE 493
R+ +Q E E ++L +EE ++ +AE+ + + ++L++ +Q E
Sbjct: 2516 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2575
Query: 494 QSENLQVQLEHLQSRLR 510
+++ L+ QL+ L+ + R
Sbjct: 2576 ENQRLREQLQLLEEQHR 2592
Score = 63.5 bits (153), Expect = 5e-10
Identities = 122/533 (22%), Positives = 223/533 (41%), Gaps = 76/533 (14%)
Query: 59 PAPALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRA 118
P L+A+ ++ S ++L ++ + AQ E +R C + ++ ++ A R
Sbjct: 934 PEDRLMAEREYGSCSH-HYQQLLQSLEQGAQEESRCQR---CISELKDIRLQLEACETRT 989
Query: 119 REEVRQLRQRLDAL-TKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPE 177
V +LR LD +E A E+Q+AQ E E G+ +ARL A++ PEP
Sbjct: 990 ---VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPS 1043
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRL 237
+R ELEL L+ + S E + RG+ G +E R
Sbjct: 1044 PAAPTLR----------SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1093
Query: 238 PWED--------TAATEEEASKLTALRLRLD-ESQKVLLKEREDKLALSRNI-EKLEG-- 285
E E EA+K + +LR E+Q+ D+L ++ + E+L+
Sbjct: 1094 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1153
Query: 286 -----ELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRM---SEDLEDELGARSSMD 337
E+ +W+ + +L + Q +L Q + ++ ++LGR + D LGA
Sbjct: 1154 GERDVEVERWRERVAQLLERWQAVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQDA 1212
Query: 338 RKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRA----------QVGDLEE 387
R+ E M ++ E R+E+ E+ +ER +K+ + D E
Sbjct: 1213 RRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYEL 1270
Query: 388 ALARRRRQ----TASALDCDLRASQAALFEKNKEL----ADLKHVHGKLKKQFQEKVAEL 439
L + Q + A +++ ++ ++ +L ++L + + K E + +
Sbjct: 1271 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1330
Query: 440 AHANRRVEQHEAEVKKLRLRVE---ELKKELAQAEDELD-EAHNQARKLQRSLDEQT--- 492
R EQ AE ++ VE E +++LA+A + +A +A++LQ+ + E+
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 493 -EQSENLQVQLEHLQSRLR--RQQQNAPLFGKIRSARFGTEEAEDGTSDLDED 542
E + + Q Q +Q L+ RQ A + K R A E AE ++E+
Sbjct: 1391 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA----EAAERSRLRIEEE 1439
Score = 61.2 bits (147), Expect = 2e-09
Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 52/414 (12%)
Query: 73 EELRLRELEEARAR---AAQMEKTMRRWSD-CTANWREKWSKVRAERNRAREEVRQLRQR 128
E +++++ E AR AAQ +R+ ++ A R K+ E+ +A +E +L+
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2314
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP-EAEREPVRDVG 187
+ L ++ A+ + + Q + E ++LA ++T+ EAER+ ++
Sbjct: 2315 AELLQQQKELAQEQARRLQEDKEQMAQQLA---------EETQGFQRTLEAERQRQLEMS 2365
Query: 188 SERPPGSQELEL-VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATE 246
+E ++ L+L V + ++ ED R +E AT+
Sbjct: 2366 AE----AERLKLRVAEMSRAQARAEEDAQRFRKQA----------EEIGEKLHRTELATQ 2411
Query: 247 EEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLK 306
E+ + + L ++ +S + RE L R EKL+ E ++K EE+ +QE L
Sbjct: 2412 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2471
Query: 307 QLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL-QAENAAEWGRRERLE 365
Q E + + E + +R + + + ++E+L Q E A RE +
Sbjct: 2472 Q----------ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2521
Query: 366 TEKLGLERENKKLRAQVGDLE------EALARRRRQTASALDCDLRASQAALFEKNKELA 419
++ +E+E ++L A + + E RR+++ L+ R + L E+N+ L
Sbjct: 2522 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2581
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ +L+ ++ A LAH+ A K L + L A+AE E
Sbjct: 2582 E------QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2629
Score = 30.4 bits (67), Expect = 4.4
Identities = 60/276 (21%), Positives = 104/276 (37%), Gaps = 13/276 (4%)
Query: 242 TAATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
T EE+ L +L L L +SQ ED+L R Q E+
Sbjct: 902 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 961
Query: 298 SKTKQEMLKQLSILKEAH-QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE--N 354
++ + + +S LK+ Q E L R+ A+ E ++ QAE
Sbjct: 962 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1021
Query: 355 AAEWGRRERLETEK-LGLERENKKLRAQVGDLEEALARRRR-QTASALDCDLRASQAALF 412
+ R E EK L L + +LE L + + ++ SA+ + + + +
Sbjct: 1022 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1081
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
+ ++ H + K+ Q A L +E +A +KKLR + E + D
Sbjct: 1082 RGTQGAEEVLRAHEEQLKEAQAVPATLPE----LEATKASLKKLRAQAEAQQPTFDALRD 1137
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR 508
EL A +LQ+ E+ + E + ++ L R
Sbjct: 1138 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1173
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 96.7 bits (239), Expect = 5e-20
Identities = 132/499 (26%), Positives = 225/499 (45%), Gaps = 63/499 (12%)
Query: 71 SREELRLRELEEARARAAQM--EKTMRRWSDCTANWREKWS------KVRAERNRAREEV 122
+ E RLR L E R Q+ E R+ ++ EK + +++ E A +E
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1886
Query: 123 RQLRQRLDALTKELAGARR--ERQEAQGECEARGRELARLRGARG---------VADQTR 171
+RL L ++ A RR E Q AQ + + R LA+LR A V D R
Sbjct: 1887 EAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER-LAQLRKASDSELERQKGLVEDTLR 1945
Query: 172 DGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
+ E E ++ + G ELEL ++S E++ E L A R +
Sbjct: 1946 QRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAE 2005
Query: 232 QERSRLPWED----TAATEEEASK--------LTALRLRLDESQKVLLKEREDKLALSRN 279
+ER R E+ + A EEEA++ + L+ +++E+++ L+ER ++ + +R
Sbjct: 2006 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR--LRERAEQES-ARQ 2062
Query: 280 IEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRK 339
++ L E +Q +++ EE + K+ + + Q++ + D+L + R+
Sbjct: 2063 LQ-LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ------SVLDQLRGEAEAARR 2115
Query: 340 MAELRGEMERLQAENAAEWGRRERLETEKLGLERENK-KLRAQVGDLEEALARRRRQTAS 398
AE E R+QAE A RR+ E E+L E + + RAQ E L + Q A+
Sbjct: 2116 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 399 ALDCDLRASQAALFEKNKELADL-KHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLR 457
+A QAAL +K A++ KH K+F E+ R+ Q E E+ LR
Sbjct: 2175 RR---AQAEQAALRQKQAADAEMEKH------KKFAEQTL------RQKAQVEQELTTLR 2219
Query: 458 LRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEH---LQSRLRRQQQ 514
L++EE + ++EL +A + R + E+ +++VQ+E L++R+ + +
Sbjct: 2220 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2279
Query: 515 NAPLFGKIRSARFGTEEAE 533
L K + RF EEAE
Sbjct: 2280 ALILRDKDNTQRFLQEEAE 2298
Score = 88.2 bits (217), Expect = 2e-17
Identities = 135/555 (24%), Positives = 239/555 (43%), Gaps = 102/555 (18%)
Query: 74 ELRLRELEEARARAAQME-KTMRRWSDCT-----ANWREKWSKVRAERNRAREEVRQLRQ 127
E RLR+ E RAR Q+ +T +R ++ A++ EK +++ V QLR+
Sbjct: 1576 ERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1635
Query: 128 RLDALTKELAGARRERQEAQGECEA---RGRELARLR-------GARGVADQTRDGPEPE 177
+ ++ A A R R+EA+ E E + E RLR + +A + + E
Sbjct: 1636 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1695
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEAR--------SLGAGGPRGSS 229
AERE R G ++ EL E L+ + +E + R L A +G
Sbjct: 1696 AERE-ARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQ 1754
Query: 230 GRQ----ERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLK-----EREDKLALSRNI 280
RQ E +RL E AAT++ +L A ++ +VLL E E + ++
Sbjct: 1755 QRQLLEEELARLQREAAAATQKR-QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1813
Query: 281 EKLEGELSQWKIKYEELSKTK---QEMLKQLSIL-------------------------- 311
++LE E +++ EE ++ + +E +Q +
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1873
Query: 312 ------------KEAHQDELGRMSED-------LEDELGA-RSSMDRKMAELR----GEM 347
KEA + L R++ED LE++ ++ ++ ++A+LR E+
Sbjct: 1874 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1933
Query: 348 ERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRAS 407
ER + +R ++E E L L+ +K A +LE L R R S + LR+
Sbjct: 1934 ERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR----SNAEDTLRSK 1989
Query: 408 QAALFEKNKE---LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
+ A E ++ A+ + + +++ Q+ +A A R+ + EV++L+ +VEE +
Sbjct: 1990 EQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEAR 2049
Query: 465 KELAQAEDE----LDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA-PLF 519
+ +AE E L A A+K R E+ + +Q + + LQ L+++Q L
Sbjct: 2050 RLRERAEQESARQLQLAQEAAQK--RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107
Query: 520 GKIRSARFGTEEAED 534
G+ +AR EEAE+
Sbjct: 2108 GEAEAARRAAEEAEE 2122
Score = 84.7 bits (208), Expect = 2e-16
Identities = 117/510 (22%), Positives = 212/510 (41%), Gaps = 58/510 (11%)
Query: 62 ALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREE 121
+L A+ + + + L E+E +A+ + + R +A + + +R +A E+
Sbjct: 2020 SLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2079
Query: 122 VRQ--LRQRLDALTKELAGARRERQEAQGECEARGR-----ELARLRGARGVADQTRDGP 174
++Q+ L + L + + +GE EA R E AR++ R A R
Sbjct: 2080 AHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE 2139
Query: 175 EPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQER 234
E E ++ + R +Q E L K +E+ +A + + E+
Sbjct: 2140 EAERLKQSAEEQAQAR---AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK 2196
Query: 235 SRLPWEDTAATEEEASK-LTALRLRLDES--QKVLLKEREDKLAL-----SRNIEKLEGE 286
+ E T + + + LT LRL+L+E+ QK LL E +L +R ++E E
Sbjct: 2197 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2256
Query: 287 LSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGE 346
L +++ EELSK K + + L +D R L++E KM ++ E
Sbjct: 2257 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRF---LQEEA-------EKMKQVAEE 2306
Query: 347 MERLQAENAAEWGRRERLETEKLGLERE--NKKLRAQVGDLEEALARRRRQTASALDCDL 404
RL A E R +L E L +R K L+ ++ ++EA + +L
Sbjct: 2307 AARLSVA-AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL 2365
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELK 464
QA +++KE + +L ++ Q L +R + AE ++L+LRV E+
Sbjct: 2366 AQEQARRLQEDKE-----QMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMS 2420
Query: 465 KELAQAEDELDEAHNQARK-----------------LQRSLDEQTEQS----ENLQVQLE 503
+ A+AE++ QA + L ++L+ Q +QS E L+ +
Sbjct: 2421 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIA 2480
Query: 504 HLQSRLRRQQQNAPLFGKIRSARFGTEEAE 533
L+ + QQ A L +++S T + E
Sbjct: 2481 ELEREKEKLQQEAKLL-QLKSEEMQTVQQE 2509
Score = 77.0 bits (188), Expect = 4e-14
Identities = 111/459 (24%), Positives = 196/459 (42%), Gaps = 27/459 (5%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANW---REKWSKVRAERNRAREEVRQLR 126
E+ E RLR EE R Q+E T R+ R + + A++ +A+EE +LR
Sbjct: 1468 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1527
Query: 127 QRLDALTK-----ELAGARRERQEAQGECEARGRELARLRGARGVADQT-RDGPEPEAER 180
+++ ++ E+ A R + EA+ E + R L L R A++ R + E ER
Sbjct: 1528 RQVQDESQRKRQAEVELASRVKAEAEAAREKQ-RALQALEELRLQAEEAERRLRQAEVER 1586
Query: 181 EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQE---RSRL 237
V E S E EL +S S E++ RSL + R+E R++
Sbjct: 1587 ARQVQVALETAQRSAEAEL-QSKRASFAEKTAQL--ERSLQEEHVAVAQLREEAERRAQQ 1643
Query: 238 PWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
E A EE +L +L+ +E+ ++ L+ E +A +++ + E E + + + E
Sbjct: 1644 QAEAERAREEAERELERWQLKANEALRLRLQAEE--VAQQKSLAQAEAEKQKEEAEREAR 1701
Query: 298 SKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAE 357
+ K E + Q EL + + +L ++ R AE E+ RL+AE
Sbjct: 1702 RRGKAEE-------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ--ELIRLRAETEQG 1752
Query: 358 WGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKE 417
+R+ LE E L+RE + +LE LA+ R + L RA + + K
Sbjct: 1753 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1812
Query: 418 LADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEA 477
L+ G+ ++ +E A A Q + + + E ++ LA+ + EA
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1872
Query: 478 HNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA 516
+ + +L E+ ++E L+ E + RR ++ A
Sbjct: 1873 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911
Score = 73.6 bits (179), Expect = 5e-13
Identities = 113/498 (22%), Positives = 212/498 (42%), Gaps = 53/498 (10%)
Query: 72 REELR-LREL-EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQL---- 125
R+ELR +E+ E + R + + + RW + A E+W V A+ + + E+ QL
Sbjct: 1177 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1236
Query: 126 ---RQRLDALTKELAGARRERQEAQGECEARGREL-ARLRGARGVADQTRDGPE--PEAE 179
R+ D L L ARR +++ Q A + + +LR + + ++ E E +
Sbjct: 1237 RYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1296
Query: 180 REPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
R + + + + EL+LV + P S A P+ SG E +
Sbjct: 1297 RFAKQYINAIK---DYELQLVTYKAQLEPVASP---------AKKPKVQSG-SESVIQEY 1343
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIE------KLEGELSQWKIK 293
D E + LT+ ++ S+ + E E++LA + E ++E L + +
Sbjct: 1344 VDLRTHYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1402
Query: 294 YEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE 353
E ++ K + ++ L++ Q+E+ R E D + S+ ++ +LR E AE
Sbjct: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE---AE 1459
Query: 354 NAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFE 413
A+ + E E +L +E E + +R Q+ EA R+R + +L+A +A E
Sbjct: 1460 IQAKARQAEAAERSRLRIEEEIRVVRLQL----EATERQR----GGAEGELQALRARAEE 1511
Query: 414 KNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ + +L++Q Q++ ++R Q E E+ E +E +A
Sbjct: 1512 AEAQKRQAQEEAERLRRQVQDE-------SQRKRQAEVELASRVKAEAEAAREKQRALQA 1564
Query: 474 LDEAHNQARKLQRSLDE-QTEQSENLQVQLEHLQ--SRLRRQQQNAPLFGKIRSARFGTE 530
L+E QA + +R L + + E++ +QV LE Q + Q + A K +
Sbjct: 1565 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
Query: 531 EAEDGTSDLDEDEDLQIQ 548
E + L E+ + + Q
Sbjct: 1625 EEHVAVAQLREEAERRAQ 1642
Score = 68.2 bits (165), Expect = 2e-11
Identities = 110/497 (22%), Positives = 217/497 (43%), Gaps = 85/497 (17%)
Query: 73 EELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ-------- 124
E+LR +E E+ AR AQ E+ R EK K + R + +V Q
Sbjct: 2163 EKLR-KEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ 2221
Query: 125 ----------LRQRLDALTKELAGARRERQEAQGEC---EARGRELARLRG---ARGVA- 167
L + L L E A R+R + + E + EL++L+ A A
Sbjct: 2222 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2281
Query: 168 -----DQTRDGPEPEAER-EPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLG 221
D T+ + EAE+ + V + + +QE + L + ED + R+L
Sbjct: 2282 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE------EDLAQQRALA 2335
Query: 222 AGGPRGS-SGRQERSRLPWE-DTAATEEEASKLTALRLRLDESQ-------------KVL 266
+ QE +RL E + ++E ++ A RL+ D+ Q + L
Sbjct: 2336 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTL 2395
Query: 267 LKEREDKLALSRNIEKLE---GELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMS 323
ER+ +L +S E+L+ E+S+ + + EE ++ ++ +++ ++ H+ EL
Sbjct: 2396 EAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG--EKLHRTEL---- 2449
Query: 324 EDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRE--RLETEKLGLERENKKLRAQ 381
++ ++ E++R Q+++ AE R LE EK L++E K L+ +
Sbjct: 2450 ----------ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLK 2499
Query: 382 VGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAH 441
+++ + Q AL + + +L ++ + + K KL++ FQ++VA+
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK---AKLEQLFQDEVAKAQQ 2556
Query: 442 AN----RRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ----TE 493
R+ +Q E E ++L +EE ++ +AE+ + + ++L++ +Q E
Sbjct: 2557 LREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE 2616
Query: 494 QSENLQVQLEHLQSRLR 510
+++ L+ QL+ L+ + R
Sbjct: 2617 ENQRLREQLQLLEEQHR 2633
Score = 63.5 bits (153), Expect = 5e-10
Identities = 122/533 (22%), Positives = 223/533 (41%), Gaps = 76/533 (14%)
Query: 59 PAPALLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRA 118
P L+A+ ++ S ++L ++ + AQ E +R C + ++ ++ A R
Sbjct: 975 PEDRLMAEREYGSCSH-HYQQLLQSLEQGAQEESRCQR---CISELKDIRLQLEACETRT 1030
Query: 119 REEVRQLRQRLDAL-TKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPE 177
V +LR LD +E A E+Q+AQ E E G+ +ARL A++ PEP
Sbjct: 1031 ---VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE---AEKVLALPEPS 1084
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRL 237
+R ELEL L+ + S E + RG+ G +E R
Sbjct: 1085 PAAPTLR----------SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1134
Query: 238 PWED--------TAATEEEASKLTALRLRLD-ESQKVLLKEREDKLALSRNI-EKLEG-- 285
E E EA+K + +LR E+Q+ D+L ++ + E+L+
Sbjct: 1135 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1194
Query: 286 -----ELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRM---SEDLEDELGARSSMD 337
E+ +W+ + +L + Q +L Q + ++ ++LGR + D LGA
Sbjct: 1195 GERDVEVERWRERVAQLLERWQAVLAQTDV-RQRELEQLGRQLRYYRESADPLGAWLQDA 1253
Query: 338 RKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRA----------QVGDLEE 387
R+ E M ++ E R+E+ E+ +ER +K+ + D E
Sbjct: 1254 RRRQEQIQAMPLADSQAVREQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYEL 1311
Query: 388 ALARRRRQ----TASALDCDLRASQAALFEKNKEL----ADLKHVHGKLKKQFQEKVAEL 439
L + Q + A +++ ++ ++ +L ++L + + K E + +
Sbjct: 1312 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1371
Query: 440 AHANRRVEQHEAEVKKLRLRVE---ELKKELAQAEDELD-EAHNQARKLQRSLDEQT--- 492
R EQ AE ++ VE E +++LA+A + +A +A++LQ+ + E+
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 493 -EQSENLQVQLEHLQSRLR--RQQQNAPLFGKIRSARFGTEEAEDGTSDLDED 542
E + + Q Q +Q L+ RQ A + K R A E AE ++E+
Sbjct: 1432 EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQA----EAAERSRLRIEEE 1480
Score = 61.2 bits (147), Expect = 2e-09
Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 52/414 (12%)
Query: 73 EELRLRELEEARAR---AAQMEKTMRRWSD-CTANWREKWSKVRAERNRAREEVRQLRQR 128
E +++++ E AR AAQ +R+ ++ A R K+ E+ +A +E +L+
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2355
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEP-EAEREPVRDVG 187
+ L ++ A+ + + Q + E ++LA ++T+ EAER+ ++
Sbjct: 2356 AELLQQQKELAQEQARRLQEDKEQMAQQLA---------EETQGFQRTLEAERQRQLEMS 2406
Query: 188 SERPPGSQELEL-VESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATE 246
+E ++ L+L V + ++ ED R +E AT+
Sbjct: 2407 AE----AERLKLRVAEMSRAQARAEEDAQRFRKQA----------EEIGEKLHRTELATQ 2452
Query: 247 EEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLK 306
E+ + + L ++ +S + RE L R EKL+ E ++K EE+ +QE L
Sbjct: 2453 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL 2512
Query: 307 QLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL-QAENAAEWGRRERLE 365
Q E + + E + +R + + + ++E+L Q E A RE +
Sbjct: 2513 Q----------ETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2562
Query: 366 TEKLGLERENKKLRAQVGDLE------EALARRRRQTASALDCDLRASQAALFEKNKELA 419
++ +E+E ++L A + + E RR+++ L+ R + L E+N+ L
Sbjct: 2563 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2622
Query: 420 DLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE 473
+ +L+ ++ A LAH+ A K L + L A+AE E
Sbjct: 2623 E------QLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2670
Score = 30.4 bits (67), Expect = 4.4
Identities = 60/276 (21%), Positives = 104/276 (37%), Gaps = 13/276 (4%)
Query: 242 TAATEEEASKLTALRLR----LDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEEL 297
T EE+ L +L L L +SQ ED+L R Q E+
Sbjct: 943 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1002
Query: 298 SKTKQEMLKQLSILKEAH-QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAE--N 354
++ + + +S LK+ Q E L R+ A+ E ++ QAE
Sbjct: 1003 AQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1062
Query: 355 AAEWGRRERLETEK-LGLERENKKLRAQVGDLEEALARRRR-QTASALDCDLRASQAALF 412
+ R E EK L L + +LE L + + ++ SA+ + + + +
Sbjct: 1063 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1122
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
+ ++ H + K+ Q A L +E +A +KKLR + E + D
Sbjct: 1123 RGTQGAEEVLRAHEEQLKEAQAVPATLPE----LEATKASLKKLRAQAEAQQPTFDALRD 1178
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR 508
EL A +LQ+ E+ + E + ++ L R
Sbjct: 1179 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1214
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 92.8 bits (229), Expect = 7e-19
Identities = 115/497 (23%), Positives = 206/497 (41%), Gaps = 77/497 (15%)
Query: 77 LRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKEL 136
+R+LE + A ++K R + A W++K + +AE A++E R +L+ EL
Sbjct: 1433 MRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESR-------SLSTEL 1485
Query: 137 AGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVGSERPPGSQE 196
R +E + E RE L +E + D+ + +
Sbjct: 1486 FKMRNAYEEVVDQLETLRRENKNL-------------------QEEISDLTEQIAETGKN 1526
Query: 197 LELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAA--------TEEE 248
L+ E K + +E D A G + R +L + +EE
Sbjct: 1527 LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE 1586
Query: 249 ASKLTALRLRLDES-QKVL---LKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEM 304
+L R E+ Q VL ++ R D L L + K+EG+L++ +I+ ++ E
Sbjct: 1587 IEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKK---KMEGDLNEMEIQLGHSNRQMAET 1643
Query: 305 LKQLSILK------EAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL-----QAE 353
K L ++ + H D+ R +EDL+++L + ++R+ L E+E + Q E
Sbjct: 1644 QKHLRTVQGQLKDSQLHLDDALRSNEDLKEQL---AIVERRNGLLLEELEEMKVALEQTE 1700
Query: 354 NAAEWGRRERLE---------TEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDL 404
+E L+ ++ L KKL A + + + +++ +A +
Sbjct: 1701 RTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAK 1760
Query: 405 RA--SQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQ-----HEAEVKKLR 457
+A A + E+ K+ D ++KK ++ V +L H EQ + +++KL
Sbjct: 1761 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1820
Query: 458 LRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAP 517
RV EL+ EL + EA A K +R + E T Q+E E ++ LR Q
Sbjct: 1821 NRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAE------EDHKNILRLQDLVDK 1874
Query: 518 LFGKIRSARFGTEEAED 534
L K++S + EEAE+
Sbjct: 1875 LQAKVKSYKRQAEEAEE 1891
Score = 85.9 bits (211), Expect = 9e-17
Identities = 111/525 (21%), Positives = 217/525 (41%), Gaps = 77/525 (14%)
Query: 79 ELEEARARAAQMEKTMRRWSDCT-------ANWREKWSKVRAERNRAREEVRQLRQRLDA 131
++E + R A+ +K R + T A R+K + AE + +++++Q+L+
Sbjct: 1164 QIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLE- 1222
Query: 132 LTKELAGARRERQEAQGECEARGRELARL-RGARGVADQTRD-GPEPEAEREPVRDVGSE 189
KE + + E + EA + + + R R V DQ + + E + + + D+ +
Sbjct: 1223 --KEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQ 1280
Query: 190 RPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEA 249
+ L+ L EE E L + +E R E+T A A
Sbjct: 1281 KA----RLQTQNGELSHRVEEKESL--ISQLTKSKQALTQQLEELKRQMEEETKAKNAMA 1334
Query: 250 SKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKY--------EELSKTK 301
L + R D ++ +E+E K L R + K E++QW+ KY EEL + K
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 302 QEMLKQ-----------------LSILKEAHQDELGRMSEDLEDELGARSSMDRK----- 339
+++ ++ L K+ Q E+ + DLE A +++D+K
Sbjct: 1395 KKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFD 1454
Query: 340 --MAELRGEMERLQAENAAEWGRRERLETEKL--------------GLERENKKLRAQVG 383
+AE + +++ QAE A L TE L RENK L+ ++
Sbjct: 1455 KVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEIS 1514
Query: 384 DLEEALA------RRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVA 437
DL E +A + +T ++ + Q AL E L+H K+ + E
Sbjct: 1515 DLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE---GSLEHEESKILRVQLELSQ 1571
Query: 438 ELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSEN 497
+ +R+V + + E+++L+ + + L D + N A +L++ ++ +
Sbjct: 1572 VKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNE--- 1628
Query: 498 LQVQLEHLQSRLRRQQQN-APLFGKIRSARFGTEEAEDGTSDLDE 541
+++QL H ++ Q++ + G+++ ++ ++A DL E
Sbjct: 1629 MEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKE 1673
Score = 70.1 bits (170), Expect = 5e-12
Identities = 84/358 (23%), Positives = 167/358 (46%), Gaps = 56/358 (15%)
Query: 240 EDTAATEEEASKLTALRLRLDESQKVLLKERED-KLALSRNIEKL-------EGELSQ-- 289
ED T+EE ++ A R L+E LL+E+ D +L + E L EG +
Sbjct: 858 EDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKI 917
Query: 290 -WKIKYEELSKT---KQEMLKQLSILKEAHQDELGRMSEDLED-ELGA------RSSMDR 338
+ K +EL++ ++EM +L K +D+ + D++D EL + + +
Sbjct: 918 LLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATEN 977
Query: 339 KMAELRGEMERLQAENAAEWGRRER--------------LETEKL-GLERENKKLRAQVG 383
K+ L EM L+ EN ++ + ++ +E +K+ GL + N KL Q
Sbjct: 978 KVKNLSEEMTALE-ENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTD 1036
Query: 384 DLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHAN 443
DLE +L + ++ A L+ R + L + + DL++ +++++ ++K EL+
Sbjct: 1037 DLEGSLEQEKKLRAD-LERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQ 1095
Query: 444 RRVE-------QHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSE 496
+++ Q + ++K+L+ R+EEL++E+ + Q L R L+E +E+ E
Sbjct: 1096 AKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLE 1155
Query: 497 ------NLQVQLEHLQ----SRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDED 544
+ Q+++ + ++RR + A L + +A ++A D ++L E D
Sbjct: 1156 EASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQA-DSVAELGEQID 1212
Score = 68.9 bits (167), Expect = 1e-11
Identities = 95/458 (20%), Positives = 191/458 (41%), Gaps = 59/458 (12%)
Query: 86 RAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGARRERQE 145
++A+ EK M + +E+ ++ A R E++ L Q + L ++ +
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMD 904
Query: 146 AQGECEARGRELARLRG-----ARGVADQTRDGPEPEAEREPVRDVGSERPPGSQELELV 200
A+ CE + L + ++ E A++ + D S +LEL
Sbjct: 905 AEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELT 964
Query: 201 -----------ESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEA 249
E+ +K++ EE E S + QE + +D E++
Sbjct: 965 LTKVEKEKHATENKVKNLSEEMTALEENISKLT---KEKKSLQEAHQQTLDDLQVEEDKV 1021
Query: 250 SKLTALRLRL----DESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEML 305
+ L + +L D+ + L +E++ + L R KLEG+L + +L KQ++
Sbjct: 1022 NGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIE 1081
Query: 306 KQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLE 365
++L + + EL ++ ++DE +K+ EL+ +E L+ E AE R ++E
Sbjct: 1082 EKL----KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIE 1137
Query: 366 TEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNK---ELADLK 422
++ L RE +++ + LEEA A++ ++ + A F+K + E A L+
Sbjct: 1138 KQRSDLARELEEISER---LEEASG------ATSAQIEMNKKREAEFQKMRRDLEEATLQ 1188
Query: 423 H--VHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDEL----DE 476
H L+K+ + VAEL EQ + ++ +K++L + + EL D+
Sbjct: 1189 HEATAATLRKKQADSVAELG------EQID--------NLQRVKQKLEKEKSELKMEIDD 1234
Query: 477 AHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQ 514
+ L +S ++ Q ++++ +Q Q
Sbjct: 1235 MASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQ 1272
Score = 29.3 bits (64), Expect = 9.8
Identities = 23/103 (22%), Positives = 44/103 (42%), Gaps = 4/103 (3%)
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
E KE+A +K + K++ A ++ E L+L+V+ + L AE+
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQN 515
+ L+ + E TE+ E + E + S L +++N
Sbjct: 908 RCEGLIKSKILLEAKVKELTERLE----EEEEMNSELVAKKRN 946
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 91.7 bits (226), Expect = 2e-18
Identities = 120/514 (23%), Positives = 208/514 (40%), Gaps = 77/514 (14%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWS--------KVRAERNRAREE 121
++R RL LE R + +W+ N + WS K +A EE
Sbjct: 838 QARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEE 897
Query: 122 VRQLRQRLDALTKELAGARRERQE----------------------------AQGECEAR 153
+ LR L L LA A +RQE A+ C
Sbjct: 898 LAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLL 957
Query: 154 GRELARLRG-ARGVADQTRDGPEPEAE---------------REPVRDVGSERPPGSQEL 197
+ +L G + ++++ D E A+ ++ + D+ +E
Sbjct: 958 IKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEK 1017
Query: 198 ELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRL 257
+ E+ +K++ EE E+ A + QE + D A E+ S LT +L
Sbjct: 1018 QATENKVKNLTEEMAALDES---VARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKL 1074
Query: 258 RLDESQKVL--LKEREDKLAL--SRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKE 313
RL++ + L E+E KL + R KLEG+L + + ++ KQ++ ++L +
Sbjct: 1075 RLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKL----K 1130
Query: 314 AHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLER 373
EL ++S +EDE + M +K+ EL+ E L+ E AE R R+E ++ R
Sbjct: 1131 KKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAAR 1190
Query: 374 ENKKLRAQVGDLEEALARRR---RQTASALDCDLRASQAALFEKNKELADLKHVHGKLKK 430
E ++L ++ + A A +R R+ + L R + A +A L+ +
Sbjct: 1191 ELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAA 1250
Query: 431 QFQEKVAELAHANRRVEQHEA----EVKKLRLRVEELKKELAQA-------EDELDEAHN 479
+ E+V L +++E+ ++ EV L VE L + A A ED+L EA
Sbjct: 1251 ELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKI 1310
Query: 480 QARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQ 513
+ +LQR L + + Q LQ + L L ++
Sbjct: 1311 KVEELQRQLADASTQRGRLQTESGELSRLLEEKE 1344
Score = 90.9 bits (224), Expect = 3e-18
Identities = 105/441 (23%), Positives = 199/441 (45%), Gaps = 45/441 (10%)
Query: 89 QMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGARRERQEAQG 148
Q+E ++ S+ + E + + A R + +E +L++ +D L LA A +E+Q +
Sbjct: 963 QLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATEN 1022
Query: 149 ECEARGRELARLRGARGVADQTRDGPE-PEAEREPVRDVGSERPPGSQELELVESLLKSM 207
+ + E+A L VA T++ EA ++ + D+ +E S L + L+
Sbjct: 1023 KVKNLTEEMAALD--ESVARLTKEKKALQEAHQQALGDLQAEEDRVSA-LTKAKLRLEQQ 1079
Query: 208 PEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRLRLDESQKVLL 267
E+ E E ++++ R+ E E KLT Q+ +
Sbjct: 1080 VEDLECSLE--------------QEKKLRMDTERAKRKLEGDLKLT---------QESVA 1116
Query: 268 KEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLE 327
+DK L ++K + ELSQ ++ E+ +M K++ L +A +EL E+LE
Sbjct: 1117 DAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKEL-QARAEEL---EEELE 1172
Query: 328 DELGARSSMDRKMAELRGEME----RLQAENAAEWGRRE---RLETEKLGLERENKKLRA 380
E AR+ ++++ AE E+E RL+ A G+RE + E E L RE ++
Sbjct: 1173 AERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAAL 1232
Query: 381 QVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELA 440
+ AL R++ + A+ L + + Q + KE ++L+ L + A
Sbjct: 1233 RHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKA 1292
Query: 441 HANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDE------QTEQ 494
A + +E ++ + +++VEEL+++LA A + ++ +L R L+E Q +
Sbjct: 1293 SAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSR 1352
Query: 495 SENLQVQ-LEHLQSRLRRQQQ 514
+ L Q LE L+ +L + +
Sbjct: 1353 GKALAAQSLEELRRQLEEESK 1373
Score = 87.4 bits (215), Expect = 3e-17
Identities = 126/539 (23%), Positives = 217/539 (40%), Gaps = 111/539 (20%)
Query: 75 LRLRELEE----ARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLD 130
LRL+E EE A A+ + +EK R + + + + + ++ R L + L+
Sbjct: 1444 LRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALE 1503
Query: 131 ALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAE--REPVRDVGS 188
++ +RE + AQ E G EL RLR A + + + E + +E + D+
Sbjct: 1504 ERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTD 1563
Query: 189 ERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAAT--- 245
+ + ++ +E K++ E + A G + R +L A
Sbjct: 1564 QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR 1623
Query: 246 -----EEEASKLTALRLRLDESQKVLL----KEREDKLALSRNIEKLEGELSQWKIKYEE 296
+EE + L R ES + L + R + L L + K+EG+L+ +++
Sbjct: 1624 KLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKK---KMEGDLNDLELQLGH 1680
Query: 297 LSKTKQEM-----LKQLSILKE-AHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL 350
++ E L Q + +E A +DE R++ +L ++ A ++R+ + L E+E L
Sbjct: 1681 ATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQA---LERRASLLAAELEEL 1737
Query: 351 QAENAAEWGRRER----------------LETEKLGLERENKKLRAQV----GDLEEALA 390
+A A E G R R L ++ GL + KKL A + G++EEA
Sbjct: 1738 RA--ALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQ 1795
Query: 391 RRRR-------------------------------------QTASALDCDLR-ASQAALF 412
RR QT L L A QAAL
Sbjct: 1796 ERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALR 1855
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
K++ L+ +L+ + + + A A + V +HE VK+L + EE +K LA+ +D
Sbjct: 1856 GGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQD 1915
Query: 473 ELD--------------EAHNQA-------RKLQRSLDEQTEQSENLQVQLEHLQSRLR 510
+D EA QA RK Q LD+ E+++ + Q L++R R
Sbjct: 1916 LVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQANKLRARTR 1974
Score = 85.9 bits (211), Expect = 9e-17
Identities = 134/542 (24%), Positives = 225/542 (41%), Gaps = 97/542 (17%)
Query: 67 GDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLR 126
GD ++ E+ R+ L +A+ R Q + + +C+ E+ K+R + RA+ R+L
Sbjct: 1057 GDLQAEED-RVSALTKAKLRLEQQVEDL----ECSL---EQEKKLRMDTERAK---RKLE 1105
Query: 127 QRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGP------------ 174
L + +A A +++Q+ + + + + EL++L + V D+ G
Sbjct: 1106 GDLKLTQESVADAAQDKQQLEEKLKKKDSELSQL--SLRVEDEQLLGAQMQKKIKELQAR 1163
Query: 175 ------EPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGS 228
E EAER V +R ++ELE E SE EA AG G
Sbjct: 1164 AEELEEELEAERAARARVEKQRAEAARELE----------ELSERLEEAGGASAGQREGC 1213
Query: 229 SGRQ----------ERSRLPWEDTAAT------------EEEASKLTALRLRLDESQKVL 266
R+ E + L E T A E+ L +R +L++ + L
Sbjct: 1214 RKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSEL 1273
Query: 267 LKEREDKLALSRNIEKL--------------EGELSQWKIKYEELSKTKQEMLKQLSILK 312
E +D L+ N+E L E +LS+ KIK EEL Q L S +
Sbjct: 1274 RMEVDD---LAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEEL----QRQLADASTQR 1326
Query: 313 EAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLE 372
Q E G +S LE++ S + R A +E L+ + E + L L
Sbjct: 1327 GRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALR 1386
Query: 373 RENKKLRAQVGDLEEALARRRR--QTASALDCDLRAS-QAALFEKNKELADLKHVHGKLK 429
+ LR Q + EA A +R A+A R+ +A ++ +EL + K KL
Sbjct: 1387 HDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKK---KLA 1443
Query: 430 KQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLD 489
+ QE + AN + E +L+ E++ EL +A + R L+R+L+
Sbjct: 1444 LRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALE 1503
Query: 490 EQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLD-EDEDLQIQ 548
E+ Q E +Q +LE Q+++ L ++ R G EEA + L E+++LQ +
Sbjct: 1504 ERRRQEEEMQRELE------AAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEE 1557
Query: 549 VA 550
++
Sbjct: 1558 IS 1559
Score = 76.3 bits (186), Expect = 7e-14
Identities = 114/462 (24%), Positives = 188/462 (40%), Gaps = 71/462 (15%)
Query: 73 EELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDAL 132
+E + +L +A AAQ + +RR E+ SK ++ A V+ LR D L
Sbjct: 1343 KECLISQLSRGKALAAQSLEELRRQL-------EEESKAKSALAHA---VQALRHDCDLL 1392
Query: 133 TKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVGSERPP 192
RE+ E + E +A + L L A Q R E +A +
Sbjct: 1393 --------REQHEEEAEAQAELQRL--LSKANAEVAQWRSKYEADAIQR----------- 1431
Query: 193 GSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAAT---EEEA 249
++ELE + L +E+E+ EA + + SS + + RL E T E
Sbjct: 1432 -TEELEEAKKKLALRLQEAEEGVEAANA-----KCSSLEKAKLRLQTESEDVTLELERAT 1485
Query: 250 SKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLS 309
S AL + ++ L + R + + R +E + E + L +E L+ L
Sbjct: 1486 SAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALE 1545
Query: 310 ILKEAH---QDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLET 366
LK + Q+E+ +++ + + +++ L GE +QA G E ET
Sbjct: 1546 TLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEET 1605
Query: 367 EKLGLERENKKLRAQVG------DLEEALARRRRQTA-----SALDCDLRASQAALFEKN 415
+ L ++ E +++A+V D E A RR Q A ++LD + RA AL K
Sbjct: 1606 KTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKK 1665
Query: 416 KELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDE-- 473
K DL + +L HA R+ + +A RL +LK+E A ++E
Sbjct: 1666 KMEGDLNDLE-----------LQLGHATRQATEAQAAT---RLMQAQLKEEQAGRDEEQR 1711
Query: 474 -LDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQ 514
E H QA+ L+R + E L+ LE + R +Q
Sbjct: 1712 LAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQ 1753
Score = 72.4 bits (176), Expect = 1e-12
Identities = 118/499 (23%), Positives = 211/499 (42%), Gaps = 86/499 (17%)
Query: 77 LRELEEARARA-AQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVR--------QLRQ 127
LRE E A A A++++ + + + A WR K+ +R EE + + +
Sbjct: 1392 LREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEE 1451
Query: 128 RLDALTKELAGARRERQEAQGECEARGRELARLRGARGVAD----------QTRDGPEPE 177
++A + + + + Q E E EL R A D + R E E
Sbjct: 1452 GVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEE 1511
Query: 178 AERE------PVRDVGSE----RPPGSQELELVESLL---KSMPEESEDCWEARSLGAGG 224
+RE R +G+E R + LE +E+L K++ EE D + SL
Sbjct: 1512 MQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGK- 1570
Query: 225 PRGSSGRQERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLE 284
S E+++ A E E S++ A L+E++ L E L +++
Sbjct: 1571 ---SIQELEKTK------KALEGEKSEIQAA---LEEAEGALELEETKTL-------RIQ 1611
Query: 285 GELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELR 344
ELSQ K + + K E + + L+ HQ + + L+ E AR+ R ++
Sbjct: 1612 LELSQVKAEVDRKLAEKDE---ECANLRRNHQRAVESLQASLDAETRARNEALRLKKKME 1668
Query: 345 GEMERLQAE-----------NAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRR 393
G++ L+ + AA + +L+ E+ G + E ++L A++ + +AL RR
Sbjct: 1669 GDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEE-QRLAAELHEQAQALERR- 1726
Query: 394 RQTASALDCDLRASQAALF--EKNKELAD--LKHVHGKLKKQFQEKVAELAHANRRVEQH 449
AS L +L +AAL E+++ LA+ L +L + L + ++
Sbjct: 1727 ---ASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLL----NQKKKL 1779
Query: 450 EAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQS-------ENLQVQL 502
EA++ +L VEE +E +AE++ +A A + L ++ + S + L+ +
Sbjct: 1780 EADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTV 1839
Query: 503 EHLQSRLRRQQQNAPLFGK 521
LQ+RL +Q A GK
Sbjct: 1840 RELQARLEEAEQAALRGGK 1858
Score = 42.7 bits (99), Expect = 9e-04
Identities = 58/272 (21%), Positives = 115/272 (42%), Gaps = 29/272 (10%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRL 129
E R L ELEE RA Q E++ R E+ + + ++ + ++L L
Sbjct: 1724 ERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADL 1783
Query: 130 DALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVGSE 189
L+ E+ A +ER+EA+ + + + A +A++ + + A E ++
Sbjct: 1784 AQLSGEVEEAAQERREAEEKAK------KAITDAAMMAEELKKEQDTSAHLERMK----- 1832
Query: 190 RPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEA 249
+ LE L++ EE+E +L G + + L E A ++ A
Sbjct: 1833 -----KTLEQTVRELQARLEEAEQA----ALRGGKKQVQKLEAKVRELEAELDAEQKKHA 1883
Query: 250 SKLTALRLRLDESQKVLLKEREDKLALSRN---IEKLEGELSQWKIKYEELSKTKQEMLK 306
L +R +++ + ED+ L+R ++KL+ ++ +K ++EE + L
Sbjct: 1884 EALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLA 1943
Query: 307 QLSILKEAHQ----DELGRMSEDLEDELGARS 334
+ K H+ +E M+E ++L AR+
Sbjct: 1944 KYR--KAQHELDDAEERADMAETQANKLRART 1973
Score = 39.3 bits (90), Expect = 0.009
Identities = 41/198 (20%), Positives = 77/198 (38%), Gaps = 29/198 (14%)
Query: 337 DRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQT 396
+ ++A LR E+ L+ AA +R+ LE + + +E L Q+ ++ LA
Sbjct: 895 EEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLA------ 948
Query: 397 ASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKL 456
D + R H+ K K Q + KV EL+ R+E E L
Sbjct: 949 ----DAEERC----------------HLLIKSKVQLEGKVKELSE---RLEDEEEVNADL 985
Query: 457 RLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA 516
R +L+ E + + ++D+ K ++ + +NL ++ L + R +
Sbjct: 986 AARRRKLEDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEK 1045
Query: 517 PLFGKIRSARFGTEEAED 534
+ G +AE+
Sbjct: 1046 KALQEAHQQALGDLQAEE 1063
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 91.3 bits (225), Expect = 2e-18
Identities = 119/487 (24%), Positives = 202/487 (41%), Gaps = 62/487 (12%)
Query: 72 REELRLRE--LEEARARAAQ-MEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQR 128
+E L++ + LEE + RAA +E+ R S+ A R + + ER EE R R+
Sbjct: 708 KESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE-RAGRKG 766
Query: 129 LDA---------------LTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDG 173
L+A L +ELA A + A+ ECE +E+A R ++ D
Sbjct: 767 LEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWR------ERYEDS 820
Query: 174 PEPEAE-----REPVRDVGSERPPGSQELELVESLLKSMPEESE-----DCWEARSLGAG 223
+ EA+ +E + + E QEL+ + + + SE E L A
Sbjct: 821 QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880
Query: 224 GPRGSSGRQERS----------RLPWEDTAATEEEASKLTALRLRLDESQKVLLKE--RE 271
R QE+ E AAT +E ++L L + E Q+ +E +E
Sbjct: 881 LARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKE 940
Query: 272 DKLALSRNIEKLEGELSQW----KIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLE 327
A R E LE + + + + + + ++M +L L+ A + G+ E+
Sbjct: 941 PARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE-- 998
Query: 328 DELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEE 387
R +R++A L E R QA+ A E R LE + L+ + R + L+E
Sbjct: 999 -----RGQQEREVARLTQERGRAQADLALEKAARAELE---MRLQNALNEQRVEFATLQE 1050
Query: 388 ALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVE 447
ALA + D +L + + KEL +L+ +LK+Q +K E A +
Sbjct: 1051 ALAHALTEKEGK-DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109
Query: 448 QHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQS 507
+ + ++E L+ E+++ E + + QA L+RSL+ + LE LQ
Sbjct: 1110 EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQG 1169
Query: 508 RLRRQQQ 514
+L + Q
Sbjct: 1170 QLEEKAQ 1176
Score = 88.6 bits (218), Expect = 1e-17
Identities = 127/529 (24%), Positives = 228/529 (43%), Gaps = 96/529 (18%)
Query: 72 REELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDA 131
+E+L +E E A AQ E R T K +RAE ++ ++ ++ +++ D+
Sbjct: 1091 KEQLAKKEKEHASGSGAQSEAAGR-----TEPTGPKLEALRAEVSKLEQQCQKQQEQADS 1145
Query: 132 LTKELAGARRERQEA-------QGECEARGRELARLRGARGVADQ------TRDGPEPEA 178
L + L R R E QG+ E + +EL + A A + T+ +A
Sbjct: 1146 LERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA 1205
Query: 179 EREPVRDVGSERPPGSQELELVESLLKSMPEESE-----------DCWEARSLGAGGPRG 227
E E V G QE E SL+ S+ EE + E + L
Sbjct: 1206 EDEWKAQVAR----GRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEK 1261
Query: 228 SSGRQERSRLPWEDTAATEEEAS-KLTALRLRLD------ESQKVLLKE-REDKLALSRN 279
S +ER RL +TA+ A+ + +ALR + E Q+V + R++ + +
Sbjct: 1262 SQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER 1321
Query: 280 IEKLEGELSQWKIKY---------------------EELSKTK---QEMLKQLSILKEAH 315
E+L EL W+ K+ EL K Q++ + + ++ H
Sbjct: 1322 AEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1381
Query: 316 QDEL-------GRMSEDL---EDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLE 365
++EL G + +L + ELG + +K+AE ++L+AE A+ + L+
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
Query: 366 TEKLGLERENKKL--RAQVG------DLEEALARRRRQTASA-LDCDLRASQ----AALF 412
L EN+ L RA +G +L++A + ++ A+ D + R ++ A
Sbjct: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQST 1501
Query: 413 EKNKELADLKHVHGKLK-----KQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKEL 467
+ E+ K+ K+K ++FQE+ +L +VEQ E ++ +VEEL K+L
Sbjct: 1502 ARELEVMTAKYEGAKVKVLEERQRFQEERQKLT---AQVEQLEVFQREQTKQVEELSKKL 1558
Query: 468 AQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNA 516
A ++ + + +Q E ++++ LQ QL LQ++L +++Q A
Sbjct: 1559 ADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAA 1607
Score = 79.0 bits (193), Expect = 1e-14
Identities = 109/497 (21%), Positives = 205/497 (41%), Gaps = 75/497 (15%)
Query: 81 EEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGAR 140
+EA AA + R ++ +K+ AER EE +QL + L ++
Sbjct: 420 QEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLS 479
Query: 141 RERQEAQGECEARGR-----------ELARLRGARGVADQTRDGPEPEAEREPVR--DVG 187
+ ++E + +A G EL L DQ G + +A+ + +
Sbjct: 480 QAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTL 539
Query: 188 SERPPGSQELE-LVESLLKSMPEESEDCWE------------ARSLGAGGPRGSSGRQER 234
++ SQ L VE L S+ ++ + E A+ L + +ER
Sbjct: 540 QQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRER 599
Query: 235 SRLPWEDTAATEEEASKLTALRLRL-------DESQKVLLKEREDKLALSRNIEKLEG-- 285
+ A +E+A+KL L+ +L D +Q + + + +K LSR +E+L+
Sbjct: 600 DAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACV 659
Query: 286 -----------------ELS-----QWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMS 323
EL Q + E +++ K ++ +QL LKE+ + G +
Sbjct: 660 ETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLE 719
Query: 324 EDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVG 383
E+ A R ++EL+ E L ++ E R+ LE E+ G + +L+ Q+G
Sbjct: 720 EEKRRAADALEEQQRCISELKAETRSLVEQHKRE---RKELEEERAGRKGLEARLQ-QLG 775
Query: 384 DLEEALAR-RRRQTASAL--------DCDLRASQAALFEKNKELADLKHVHGKLKKQFQE 434
+ +A RR+ A A+ +C+ + A + + E D + + FQE
Sbjct: 776 EAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYE--DSQQEEAQYGAMFQE 833
Query: 435 KVAELAHANRRVEQHEAEVKKLRLRVEELKK-ELAQAEDELDEAH-NQARKLQRSLDEQT 492
++ L + Q E K+ +E + ++++ ++EL E H N AR LQ+ + E+
Sbjct: 834 QLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQ-VQEKE 892
Query: 493 EQSENLQVQLEHLQSRL 509
+++ L L LQ ++
Sbjct: 893 VRAQKLADDLSTLQEKM 909
Score = 74.3 bits (181), Expect = 3e-13
Identities = 114/513 (22%), Positives = 200/513 (38%), Gaps = 84/513 (16%)
Query: 80 LEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAGA 139
L A+ A ++ S W+ + ++ R E R + L + + L +++
Sbjct: 1185 LASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEK 1244
Query: 140 RRERQE------AQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVGSERPPG 193
E +E A+ E + E RL A ++ R A RE V+ + E
Sbjct: 1245 EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQ 1304
Query: 194 SQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLT 253
E + L S E +E+ + L A + Q S L E T+ + L
Sbjct: 1305 RVASENLRQELTSQAERAEEL--GQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLP 1362
Query: 254 ALRL--RLDESQKVLLKEREDKLALSRNI-----------EKLEGELSQWKIKYEELSKT 300
A L +L Q K ++L S+ ++ GEL + K E +T
Sbjct: 1363 AKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERT 1422
Query: 301 KQEM-------LKQLSILKEAH---------------------QDELGRMSEDLEDELGA 332
Q++ +QLS+LK+AH + EL + E EL A
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAA 1482
Query: 333 -RSSMDRKMAELRGEME----RLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLE- 386
R+ + ++AE++ E + L+ A G + ++ E+ + E +KL AQV LE
Sbjct: 1483 VRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEV 1542
Query: 387 ---------EALARRRR---QTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQE 434
E L+++ Q + L+A QA E +E L+ +L+ Q +
Sbjct: 1543 FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQ 1602
Query: 435 KVAELAHANRRVE----------QHEAEVKKLRLRVEELKKE----LAQAE---DELDEA 477
K H ++E Q E+++ +E+L+KE A+AE EL +A
Sbjct: 1603 KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQA 1662
Query: 478 HNQARKLQRSLDEQTEQSENLQVQLEHLQSRLR 510
+ ++ +++ T Q +L+ Q+ H +LR
Sbjct: 1663 GLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR 1695
Score = 73.6 bits (179), Expect = 5e-13
Identities = 101/409 (24%), Positives = 166/409 (40%), Gaps = 66/409 (16%)
Query: 114 ERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDG 173
+ R ++++ R D L ELA R+ E + + + RL ++
Sbjct: 215 QMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLN---EKQAAS 271
Query: 174 PEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGA----GGPRGSS 229
P E E +RD S + L E+L + ++E R + G
Sbjct: 272 PLEPKELEELRDKNE-----SLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFK 326
Query: 230 GRQERSRLPWEDTAATE--EEASKLTALRLRLD-ESQKVLLKEREDKLALSRNIEKLEGE 286
R+ S L A E EE SK T L + +K L +DK L E L+G+
Sbjct: 327 LREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGK 386
Query: 287 LSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGE 346
LSQ + + LS L++ E G + D+ ++ L+ E
Sbjct: 387 LSQ--------------LEEHLSQLQDNPPQEKGEVLGDV-----------LQLETLKQE 421
Query: 347 MERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRA 406
L A N R E LETE+ ++ KL A+ G EE +Q S+L DL++
Sbjct: 422 AATLAANNTQLQARVEMLETER---GQQEAKLLAERGHFEE-----EKQQLSSLITDLQS 473
Query: 407 SQAALFEKNKELADLKHVHG-KLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKK 465
S + L + +EL HG +L Q +EL N ++Q + E+ L+ + +E +
Sbjct: 474 SISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA 533
Query: 466 ELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQ 514
+LAQ +L +Q + S+ L+ Q+E L S L++++Q
Sbjct: 534 QLAQ-----------------TLQQQEQASQGLRHQVEQLSSSLKQKEQ 565
Score = 49.7 bits (117), Expect = 7e-06
Identities = 54/197 (27%), Positives = 90/197 (45%), Gaps = 34/197 (17%)
Query: 346 EMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLR 405
+M RL+ + A E R+ LE E EN+KL + D + A+ ++R + L+
Sbjct: 215 QMRRLKKQLADERSNRDELELELA----ENRKLLTEK-DAQIAMMQQRIDRLALLN---- 265
Query: 406 ASQAALFEKNKELADLKHVHGKLK-------KQFQEKVAELAHANRRVEQHEAEVKKLRL 458
QAA + KEL +L+ + L KQ Q+ E + +R++ Q E L
Sbjct: 266 EKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSF 325
Query: 459 RVEELKKELAQAED---ELDEAHNQA------------RKLQRSLDEQ---TEQSENLQV 500
++ E L Q +D EL E H++A ++L +L ++ E++E LQ
Sbjct: 326 KLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQG 385
Query: 501 QLEHLQSRLRRQQQNAP 517
+L L+ L + Q N P
Sbjct: 386 KLSQLEEHLSQLQDNPP 402
Score = 49.7 bits (117), Expect = 7e-06
Identities = 69/319 (21%), Positives = 137/319 (42%), Gaps = 26/319 (8%)
Query: 72 REELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDA 131
R + L EL R + A+ E+T ++ A++ E+ S ++ EE R L +R
Sbjct: 1401 RAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGER--- 1457
Query: 132 LTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVR-DVGSER 190
A R+ E + + +AR + + L R A+ + EA+ +V + +
Sbjct: 1458 -----ANLGRQFLEVELD-QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAK 1511
Query: 191 PPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEAS 250
G++ ++++E + E + + L + +E S+ + A++ +
Sbjct: 1512 YEGAK-VKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQ 1570
Query: 251 KLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSI 310
KL A++ + ESQ ++ L + +L+ +LSQ K + E K + E K
Sbjct: 1571 KLKAVQAQGGESQ-------QEAQRLQAQLNELQAQLSQ-KEQAAEHYKLQMEKAK---- 1618
Query: 311 LKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLG 370
H D + +++L+++L + + ++ ELR E ERL E + + E
Sbjct: 1619 ---THYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRH 1675
Query: 371 LERENKKLRAQVGDLEEAL 389
L + + L AQV ++ L
Sbjct: 1676 LTAQVRSLEAQVAHADQQL 1694
Score = 39.7 bits (91), Expect = 0.007
Identities = 70/277 (25%), Positives = 125/277 (45%), Gaps = 36/277 (12%)
Query: 280 IEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAH----QDELGRMSEDLEDELGARSS 335
+ +L+ +L+ + +EL E K L+ K+A Q + R++ L +E A S
Sbjct: 216 MRRLKKQLADERSNRDELELELAENRKLLTE-KDAQIAMMQQRIDRLA--LLNEKQAASP 272
Query: 336 MDRK-MAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRR 394
++ K + ELR + E L + + L+TEK ++R+ +L + GDL L R
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKL----R 328
Query: 395 QTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVA----ELAHANRRVEQHE 450
+ AS L+ Q AL E +E H K +++ EK A EL+ A + + E
Sbjct: 329 EFAS----HLQQLQDALNELTEE-------HSKATQEWLEKQAQLEKELSAALQDKKCLE 377
Query: 451 AEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRL- 509
+ + L+ ++ +L++ L+Q +D + + L+ +++ L LQ+R+
Sbjct: 378 EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 437
Query: 510 ----RRQQQNAPLFGKIRSARFGTEEAEDGTSDLDED 542
R QQ A K+ + R EE + S L D
Sbjct: 438 MLETERGQQEA----KLLAERGHFEEEKQQLSSLITD 470
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 91.3 bits (225), Expect = 2e-18
Identities = 131/524 (25%), Positives = 220/524 (41%), Gaps = 77/524 (14%)
Query: 76 RLRELEEARARAAQMEKT---MRRWSDCTANWR----EKWSKVRAERNRAREEVRQLRQR 128
R E E A+ARA+Q EKT + W+ N + EK ++ +A EV LR
Sbjct: 1135 RQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLE 1194
Query: 129 LDALTKELAGARRERQEAQGECEA---RGRELARLRGARGVADQTRDGPEPEAEREPVRD 185
L ++ GA + + Q E EA RG ++ + V D PE E E + +R+
Sbjct: 1195 LVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTD-PEMEKELQRLRE 1253
Query: 186 VGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAAT 245
++ + +L LK E ++L P+ + + L +++ T
Sbjct: 1254 EIVDKTRLIERCDLEIYQLKK---------EIQALKDTKPQVQTKEVVQEILQFQEDPQT 1304
Query: 246 EEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWK--------IKYEEL 297
+EE + +LR +L E QK + ++ + I + E ELS+ K ++YEE
Sbjct: 1305 KEEVA---SLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEE 1361
Query: 298 SKTKQEM----------LKQLSILK------EAHQDELGRMSEDLEDELGARSSMDRKMA 341
+ E L+Q+ L+ + + EL R E+LE E AR +R++
Sbjct: 1362 PGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQ 1421
Query: 342 ELRGEMERLQAENAAEWGRRERLETEKLGLE------RENKKLRAQVGDLEEALARRR-- 393
L+ + L+ E A R + T+K+ L+ RE+ LR Q LEE RR+
Sbjct: 1422 RLQQRLAALEQEEAE--AREKVTHTQKVVLQQDPQQAREHALLRLQ---LEEEQHRRQLL 1476
Query: 394 RQTASALDCDLRASQAALFEKNKELADLKHVH-GKLKKQFQEKVAELAHANRRVEQHEAE 452
L L A + A ++ L++ V G +++ Q + L +R + + E
Sbjct: 1477 EGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVE 1536
Query: 453 VKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQ 512
V +L R+ EL+ +++ ELD + KLQ + +NLQ++ LQS +
Sbjct: 1537 VSRLEARLSELEFHNSKSSKELDFLREENHKLQL-------ERQNLQLETRRLQSEINMA 1589
Query: 513 QQNAPLFGKIRSARFGT---------EEAEDGTSDLDEDEDLQI 547
+ A GT E D L +D+DL+I
Sbjct: 1590 ATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEI 1633
Score = 65.5 bits (158), Expect = 1e-10
Identities = 99/482 (20%), Positives = 194/482 (40%), Gaps = 70/482 (14%)
Query: 78 RELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ--LRQRLDALTKE 135
+EL+E R Q+E ++ + R + + R ++V L + L +
Sbjct: 897 KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRT 956
Query: 136 LAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVGSERPPGSQ 195
LA + + Q Q E EA +L R + +TRDG + +E +R + +R +
Sbjct: 957 LAEEQHKNQLLQEELEALQLQL------RALEQETRDGGQEYVVKEVLR-IEPDRAQADE 1009
Query: 196 ELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTAL 255
L+L E L ++ E L Q+R E+ + +E+ ++ +
Sbjct: 1010 VLQLREELEALRRQKGAREAEVLLL-----------QQRVAALAEEKSRAQEKVTEKEVV 1058
Query: 256 RLRLDESQKVLLKE-REDKLALSRNIEKLEGELSQWKIKYEELSKT------KQEMLKQL 308
+L+ D + ++ +ED + EK E ELS + K + L K K + + L
Sbjct: 1059 KLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVL 1118
Query: 309 SILKEAHQD-ELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETE 367
+ K+A + E+ ++ EDE + R+ EL ++ L+ ENA + ++ +
Sbjct: 1119 KVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENA-----KVVVQEK 1173
Query: 368 KLGLERENKKLRAQVGDLEEALARRRRQTASALD-----------CDLRASQAALFEKNK 416
+ R + K ++V +L L + R+ A + R Q + E K
Sbjct: 1174 VREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTK 1233
Query: 417 ELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEEL------------- 463
E+ K +++K+ Q E+ R +E+ + E+ +L+ ++ L
Sbjct: 1234 EVIKYK-TDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVV 1292
Query: 464 ------------KKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRR 511
K+E+A +L E + L+R Q EQ + +L ++ R+ +
Sbjct: 1293 QEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQ 1352
Query: 512 QQ 513
Q+
Sbjct: 1353 QE 1354
Score = 55.1 bits (131), Expect = 2e-07
Identities = 101/471 (21%), Positives = 199/471 (42%), Gaps = 46/471 (9%)
Query: 79 ELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAG 138
EL+ ++ ++E+ ++ C++ ++ + + R EV +L QR + L +++
Sbjct: 661 ELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVER 720
Query: 139 ARRERQEAQGECE--ARGRE--LARLRGARGVADQTRDG-PEPEAEREPVRDVGSERPPG 193
+ Q A+ E RG + L L Q D + E + + +++ E
Sbjct: 721 RAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR 780
Query: 194 SQELELV----ESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEE- 248
QE++ + + +++ + + + RSL SS +R+RL T EEE
Sbjct: 781 EQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEA 840
Query: 249 --ASKLTAL------RLRLDESQKVLLKEREDKLALSRNIEKL---EGELSQWKIKYEEL 297
A+K T + RL+ E LL+++ + +++ G WKI+ E
Sbjct: 841 ALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD 900
Query: 298 SKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAE--LRGEMERLQAENA 355
+T E +QL ++ Q+E+ + E R + +K+ + L ++LQ A
Sbjct: 901 EET--ERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLA 958
Query: 356 AEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKN 415
E + + L+ E LE +LRA + + + ++ D RA + +
Sbjct: 959 EEQHKNQLLQEE---LEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLR 1014
Query: 416 KELADLKHVHGKLKKQ---FQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
+EL L+ G + + Q++VA LA R ++ E + ++L Q +
Sbjct: 1015 EELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKL----------QNDP 1064
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRR-QQQNAPLFGKI 522
+L+ + Q LQ Q + E + +L LQ +L+R +++ A GKI
Sbjct: 1065 QLEAEYQQ---LQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKI 1112
Score = 39.3 bits (90), Expect = 0.009
Identities = 105/501 (20%), Positives = 186/501 (37%), Gaps = 120/501 (23%)
Query: 109 SKVRAERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVAD 168
S+ R+ R +A R L+QR + L E G + Q GR+L L G VA
Sbjct: 468 SQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQ---------GRQL--LAGLDKVAS 516
Query: 169 QTRDGPEPEAEREPVRDVGSERPPGSQELELVES-------------LLKSMPEESEDCW 215
+ +R+ G RPP Q + +S LL+ PE++
Sbjct: 517 --------DLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTA 568
Query: 216 EARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTALRL-------RLDESQKV--- 265
E + P + R+R+ EDT E +L L RL++S +
Sbjct: 569 EGEAFIQALPGSGTTPLLRTRV--EDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWE 626
Query: 266 LLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDE------- 318
LL E+ L + + L K +EL+ E+ Q S+L E Q+
Sbjct: 627 LLATHENHLNQDDTVPESSRVLDS---KGQELAAMACELQAQKSLLGEVEQNLQAAKQCS 683
Query: 319 ---LGRMSE---DLEDELGARSSMDRKMAELRGEMER----LQAENAA------------ 356
R E DLE + + ++ LR ++ER LQ+ AA
Sbjct: 684 STLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVL 743
Query: 357 ------------EWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDL 404
E ++ET+ + ++ ++ ++++ A ++ + D +L
Sbjct: 744 QFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYEL 803
Query: 405 RASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAE----------VK 454
A EK + L DL++ + K A L +V++ EA +
Sbjct: 804 EA------EKLRSLLDLENG----RSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAIN 853
Query: 455 KLRLRVEELKKELAQAEDELDEAHN------------QARKLQRSLDEQTEQSENLQVQL 502
+ RL+ E L + + E++ H +A K+++ LDE+TE+ L+ ++
Sbjct: 854 RQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEV 913
Query: 503 EHLQSRLRRQQQNAPLFGKIR 523
+ Q + + P +R
Sbjct: 914 KSTQEEIWTLRNQGPQESVVR 934
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 89.4 bits (220), Expect = 8e-18
Identities = 105/441 (23%), Positives = 190/441 (43%), Gaps = 42/441 (9%)
Query: 128 RLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVG 187
+L+A KEL+ E +E E ARGR+L E ++ + D+
Sbjct: 926 QLEARVKELSERVEEEEEINSELTARGRKLE---------------DECFELKKEIDDLE 970
Query: 188 SERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEE 247
+ +E E +K++ EE E E S R + QE + +D EE
Sbjct: 971 TMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLN---RAAKVVQEAHQQTLDDLHMEEE 1027
Query: 248 EASKLTALRLRL----DESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQE 303
+ S L+ L+L DE + L +ER+ ++ R + KLEG L + E L +++
Sbjct: 1028 KLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRH 1087
Query: 304 MLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRER 363
+ ++L + EL +M+ +E+E G + + + + EL+ +++ L+ + AE R +
Sbjct: 1088 LAEEL----RKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAK 1143
Query: 364 LETEKLGLERE----NKKLRAQVGDLEEALARRRRQTASALDCDLRASQAAL-FEKNKEL 418
+E E+ L ++ N++L G L ++Q +A L FE
Sbjct: 1144 MERERADLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTS-- 1201
Query: 419 ADLKHVHGKLKKQFQEKVAELAHANRRVEQHEA----EVKKLRLRVEELKKELAQAEDEL 474
A LK H + + +V L +++E+ ++ EV L RVE++ + A AE
Sbjct: 1202 ASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLC 1261
Query: 475 DEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSR----LRRQQQNAPLFGKI-RSARFGT 529
+ + LD+ T+ + +L Q L S LRR ++ L ++ R T
Sbjct: 1262 TLYEERLHEATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFT 1321
Query: 530 EEAEDGTSDLDEDEDLQIQVA 550
+ ED L+++ Q +A
Sbjct: 1322 RQIEDLRGQLEKETKSQSALA 1342
Score = 80.5 bits (197), Expect = 4e-15
Identities = 106/466 (22%), Positives = 213/466 (45%), Gaps = 51/466 (10%)
Query: 77 LRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKEL 136
L +L + R+ AA++++ + A+W++K + +A + +++EV+ AL+ EL
Sbjct: 1441 LSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQALLDASQKEVQ-------ALSTEL 1493
Query: 137 AGARRERQEAQGECEARGRELARLRGA-RGVADQTRDGPEPEAEREPVRDVGSERPPGSQ 195
+ +E+ E RE L+ + +Q R+G + E E V+ + E Q
Sbjct: 1494 LKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQ 1553
Query: 196 -ELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKLTA 254
LE E L+ ES+ L + ++ L + + EE +
Sbjct: 1554 VTLEETEGALER--NESKILHFQLEL----------LEAKAELERKLSEKDEEIENFRRK 1601
Query: 255 LRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILK-- 312
+ +D Q L E + ++ ++R +K+E +L++ +++ ++ E K L L+
Sbjct: 1602 QQCTIDSLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQ 1661
Query: 313 ----EAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQA-ENAAEWGRR----ER 363
+ D+ +++ DL++++ +R+ + L+ E+E L++ + E GRR E
Sbjct: 1662 IKDLQMQLDDSTQLNSDLKEQVAVA---ERRNSLLQSELEDLRSLQEQTERGRRLSEEEL 1718
Query: 364 LE-TEKLGL-ERENKKLRAQVGDLEEALARRRRQTASAL----DCDLRASQAA------- 410
LE TE++ L +N L +Q LE +AR +++ + + + +A +AA
Sbjct: 1719 LEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLS 1778
Query: 411 --LFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQ-HEAEVKKLRLRVEELKKEL 467
L +K +A L+ +++ + LA A + +++KL RV EL+ EL
Sbjct: 1779 EELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGEL 1838
Query: 468 AQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQ 513
EA AR+L+R + E T Q+E + L +Q+++ + Q
Sbjct: 1839 EGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSRMQTQMDKLQ 1884
Score = 66.2 bits (160), Expect = 7e-11
Identities = 112/498 (22%), Positives = 207/498 (41%), Gaps = 77/498 (15%)
Query: 73 EELRLRELEEARARA---------AQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVR 123
EELR +ELE ++ + AQ++KT++ + +EK R R + E
Sbjct: 1090 EELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERA 1149
Query: 124 QLRQRLDALTK---ELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGP------ 174
L Q L L + E+ G+ + E + E + ++L R + +T
Sbjct: 1150 DLTQDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHA 1209
Query: 175 ----EPEAEREPVRDVGSERPPGSQELEL-VESLL---KSMPEESEDCWEARSLGAGGPR 226
E E + E ++ V + +L+L V+ LL + M + + +L
Sbjct: 1210 DSLAELEGQVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLH 1269
Query: 227 GSSGRQERSRLPWEDTAATEEEA-SKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEG 285
++ + ++ D AA + + S+ RL+E + ++ + +K +R IE L G
Sbjct: 1270 EATAKLDKVTQLANDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRG 1329
Query: 286 ELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDEL-GARSSMDRKMAELR 344
+L + L+ Q+ + +L+E +++E ++++ EL S ++ +M + R
Sbjct: 1330 QLEKETKSQSALAHALQKAQRDCDLLREQYEEE-----QEVKAELHRTLSKVNAEMVQWR 1384
Query: 345 GEMER--LQAENAAEWGRRE---RLE--TEKLG--------LERENKKLRAQVGDLEEAL 389
+ E +Q E ++E RL+ E +G LER +L+ ++GD L
Sbjct: 1385 MKYENNVIQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDL 1444
Query: 390 ARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQH 449
+ R A R Q L + K LAD K H +E A L + + V+
Sbjct: 1445 GKVRSAAA-------RLDQKQL-QSGKALADWKQKH-------EESQALLDASQKEVQAL 1489
Query: 450 EAEVKKLRLRVEE-------LKKELAQAEDELDEAHNQARKLQRSLDEQ-------TEQS 495
E+ KL+ EE L++E ++E+ NQ R+ ++L E E+
Sbjct: 1490 STELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEK 1549
Query: 496 ENLQVQLEHLQSRLRRQQ 513
+QV LE + L R +
Sbjct: 1550 TEVQVTLEETEGALERNE 1567
Score = 65.1 bits (157), Expect = 2e-10
Identities = 53/244 (21%), Positives = 109/244 (44%), Gaps = 12/244 (4%)
Query: 270 REDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDE 329
+E+ L + +EK E + + K K L++ K +++ QL +A Q+ L + E E
Sbjct: 865 KEECAQLQKALEKSEFQREELKAKQVSLTQEKNDLILQL----QAEQETLANVEEQCEWL 920
Query: 330 LGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEAL 389
+ ++ ++ ++ EL +E + N+ R +LE E L++E + DLE L
Sbjct: 921 IKSKIQLEARVKELSERVEEEEEINSELTARGRKLEDECFELKKE-------IDDLETML 973
Query: 390 ARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQH 449
+ ++ + ++ F N++++ L +++ Q+ + +L ++
Sbjct: 974 VKSEKEKRTTEHKVKNLTEEVEF-LNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSL 1032
Query: 450 EAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRL 509
KL +V+EL+ L Q + KL+ +L E ENL+ HL L
Sbjct: 1033 SKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEEL 1092
Query: 510 RRQQ 513
R+++
Sbjct: 1093 RKKE 1096
Score = 63.5 bits (153), Expect = 5e-10
Identities = 117/500 (23%), Positives = 205/500 (41%), Gaps = 93/500 (18%)
Query: 74 ELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQ---LRQRLD 130
+L + EE + A++ +T+ + + WR K+ +R E+ ++ +R +
Sbjct: 1353 DLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEA 1412
Query: 131 ALTKELAGAR-----RERQEAQGECEARGRELARLRGARGVADQTR--------DGPEPE 177
A +A AR R R + Q E +L ++R A DQ + D +
Sbjct: 1413 AEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKH 1472
Query: 178 AEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRL 237
E + + D S++ + EL++ LK+ EES E R+E L
Sbjct: 1473 EESQALLDA-SQKEVQALSTELLK--LKNTYEESIVGQETL------------RRENKNL 1517
Query: 238 PWEDTAATEE--EASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYE 295
E + T + E +K L E +KV E+K + +E+ EG L + + K
Sbjct: 1518 QEEISNLTNQVREGTK------NLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKIL 1571
Query: 296 ----ELSKTKQEMLKQLSILKEA-------HQDELGRMSEDLEDELGARSSMDR---KMA 341
EL + K E+ ++LS E Q + + L+ E +R + R KM
Sbjct: 1572 HFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKKME 1631
Query: 342 ELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALD 401
E EME LQ A R+ T+ LG +L+ Q+ DL+ L ++ L+
Sbjct: 1632 EDLNEME-LQLSCA---NRQVSEATKSLG------QLQIQIKDLQMQL-----DDSTQLN 1676
Query: 402 CDLRASQAALFEKNK----ELADLKHVHGKLKKQFQEKVAELAHANRRV----------- 446
DL+ A +N EL DL+ + + ++ + EL A R+
Sbjct: 1677 SDLKEQVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLL 1736
Query: 447 ---EQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTE-------QSE 496
++ EA+V +++ EE+ +E AE++ +A +A L L ++ + E
Sbjct: 1737 SQKKKLEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRE 1796
Query: 497 NLQVQLEHLQSRLRRQQQNA 516
N++ + LQ RL +Q A
Sbjct: 1797 NMEQTITDLQKRLAEAEQMA 1816
Score = 62.8 bits (151), Expect = 8e-10
Identities = 80/342 (23%), Positives = 153/342 (44%), Gaps = 42/342 (12%)
Query: 246 EEEASKLTALRLRLDESQKV--LLKER-----EDKLALSRNIEKLEGELSQWKIKY---- 294
E+E +AL L ++Q+ LL+E+ E K L R + K+ E+ QW++KY
Sbjct: 1332 EKETKSQSALAHALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNV 1391
Query: 295 ----EELSKTKQEMLKQLSILKE------AHQDELGRMSEDLEDELG-ARSSMDR-KMAE 342
E+L K+E+ +L E A L R L+ ELG A S + + + A
Sbjct: 1392 IQRTEDLEDAKKELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAA 1451
Query: 343 LRGEMERLQAENA-AEWGRRERLETEKLGLERENKKLRAQVGDL-------EEALARRR- 393
R + ++LQ+ A A+W +++ E + L+ K+++A +L EE++ +
Sbjct: 1452 ARLDQKQLQSGKALADW--KQKHEESQALLDASQKEVQALSTELLKLKNTYEESIVGQET 1509
Query: 394 -RQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAE 452
R+ L ++ + E K L +++ V ++++ E L +E++E++
Sbjct: 1510 LRRENKNLQEEISNLTNQVREGTKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESK 1569
Query: 453 VKKLRLRVEELKKELAQAEDELDEAHNQARKLQR----SLDEQTEQSENLQVQLEHLQSR 508
+ +L + E K EL + E DE R+ Q+ SL + ++++ L+ +
Sbjct: 1570 ILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTIDSLQSSLDSEAKSRIEVTRLKKK 1629
Query: 509 LRRQQQNAPLFGKIRSARFGTEEAEDGTSDLD-EDEDLQIQV 549
+ L ++ A EA L + +DLQ+Q+
Sbjct: 1630 MEEDLNEMEL--QLSCANRQVSEATKSLGQLQIQIKDLQMQL 1669
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 87.8 bits (216), Expect = 2e-17
Identities = 115/503 (22%), Positives = 215/503 (42%), Gaps = 63/503 (12%)
Query: 72 REELRLR--ELEEARARAAQMEKTMRRWSDCTANWR---EKWSKVRAERNRAREEVRQLR 126
REEL ++ ++E + A ++K M++ + + E + + +++ E++ R
Sbjct: 814 REELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATR 873
Query: 127 QRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDV 186
+RLD+ KEL R+E + GE EL+RL R VA + + E + +
Sbjct: 874 KRLDSELKEL---RQELMQVHGEKRTAEAELSRLH--REVAQVRQHMADLEGHLQSAQKE 928
Query: 187 GSERPPGSQELELVESLLKSMPEESEDCW-EARSLGAGGPRG-SSGRQERSRLPWEDTAA 244
E Q L+ + + ++ E +E + L + + +Q+ RL + T+A
Sbjct: 929 RDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSA 988
Query: 245 TEEEASKLTA-------LRLRLDESQKVLLKERED---------------KLALSRNIEK 282
+E +K A L RL E+ + KE D LAL I+
Sbjct: 989 QKEMKTKHKAYENAVGILSRRLQEA--LAAKEAADAELGQLRAQGGSSDSSLALHERIQA 1046
Query: 283 LEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDR---- 338
LE EL L K QE++ S E ++++ + ++L++ G R + R
Sbjct: 1047 LEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEES 1106
Query: 339 ------KMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDL---EEAL 389
++ +G++ L NAA LET E + +L QV + +E
Sbjct: 1107 NKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEE 1166
Query: 390 ARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQH 449
R+ + AL L + + +++A K G ++ F+ EL+ + ++
Sbjct: 1167 DRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAK 1226
Query: 450 EAEVKKLRLRVEELK-------KELAQAEDELDEAHNQARKLQRSLDEQ-------TEQS 495
E V+KL+ ++L+ +E+AQ + EL EA Q + LQ+ LDEQ ++
Sbjct: 1227 EHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEM 1286
Query: 496 ENLQVQLEHLQSRLRRQQQNAPL 518
ENL+ +++ + ++ +Q L
Sbjct: 1287 ENLKWEVDQKEREIQSLKQQLDL 1309
Score = 74.3 bits (181), Expect = 3e-13
Identities = 111/498 (22%), Positives = 208/498 (41%), Gaps = 86/498 (17%)
Query: 71 SREELRLRELEEAR--ARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQR 128
S +L++ E + R A+ M+++M + + R++ + ++++ + + E L +
Sbjct: 501 SNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSK 560
Query: 129 LDALTKELAGARRERQEAQGECEARGRELARLRGARG---VADQTRDGPEPEAEREPVRD 185
L A E++ + RQ Q + RL+G V T+ G + E V
Sbjct: 561 LKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENV-- 618
Query: 186 VGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAAT 245
S +L E+ +SM E+ + + + A QE + + ++
Sbjct: 619 --------SLSQQLTETQHRSMKEKGRIAAQLQGIEA-----DMLDQEAAFMQIQEAKTM 665
Query: 246 EEEASKLTALRLRLDESQKVLLKEREDKLA-LSRNIEKLEGELSQWKIKYEELSKTKQEM 304
EE + RL E ++ L+ D A L + +E+++ L Q + E L + ++
Sbjct: 666 VEEDLQR---RLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDL 722
Query: 305 LKQLSILKEA-------------HQDELGRMSEDLEDELGARSS---------------- 335
+KQL++ +EA H DEL +L+ E +R
Sbjct: 723 MKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAAL 782
Query: 336 ----------------MDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLR 379
++ E +E+L+ E A + G+ E L+ E L+++ +K++
Sbjct: 783 QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIK 842
Query: 380 AQVGDLEEALARRRRQTASA--LDCDLRASQAALFEKNKELA-DLKHVHGKLKKQFQEKV 436
Q + + RR S L +L+A++ L + KEL +L VHG+ K+ E
Sbjct: 843 EQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGE--KRTAE-- 898
Query: 437 AELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ---TE 493
AEL+ +R EV ++R + +L+ L A+ E DE + LQ ++ TE
Sbjct: 899 AELSRLHR-------EVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTE 951
Query: 494 QSENLQVQLEHLQSRLRR 511
+E L+ Q+E LQ R+
Sbjct: 952 ANEALKKQIEELQQEARK 969
Score = 72.4 bits (176), Expect = 1e-12
Identities = 101/504 (20%), Positives = 219/504 (43%), Gaps = 43/504 (8%)
Query: 68 DWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQ 127
D S+++L + EL+ R R K +R+ + EK + AE +R EV Q+RQ
Sbjct: 858 DATSKDQL-ISELKATRKRLDSELKELRQ--ELMQVHGEKRT-AEAELSRLHREVAQVRQ 913
Query: 128 RLDALTKELAGARRERQEAQGECEARG---RELARLRGARGVADQTRDGPEPEA------ 178
+ L L A++ER E + ++ ++ + A + + + EA
Sbjct: 914 HMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITE 973
Query: 179 EREPVRDVGSERPPGSQEL-------ELVESLLKSMPEESEDCWEARSLGAGGPRGSSGR 231
+++ +R +GS+ +E+ E +L +E+ EA G R G
Sbjct: 974 QKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGS 1033
Query: 232 QERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRN-IEKLEGELSQW 290
+ S E A E E ++ + L++ + ++ +L SR + +LE EL +
Sbjct: 1034 SDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQES 1093
Query: 291 KIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERL 350
+ + + K +E K+L++ E + +L + + S ++ +A+ ++ +L
Sbjct: 1094 R-GFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQL 1152
Query: 351 QAENAAEWGRRERLETE--------KLGLERENKK---LRAQVGDLEEALARRRRQTASA 399
+ A R+E + + + LE+E +K L+ QV + RR
Sbjct: 1153 NLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRH---- 1208
Query: 400 LDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLR 459
+A+ L E KEL +H+ KL+ + + ++ + Q +AE+ + R +
Sbjct: 1209 ----FKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQ 1264
Query: 460 VEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLF 519
++ L+K+L + + + + L+ +D++ + ++L+ QL+ + + R++ + L
Sbjct: 1265 LQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEG--LQ 1322
Query: 520 GKIRSARFGTEEAEDGTSDLDEDE 543
+++ + E A++ S +D+
Sbjct: 1323 QLLQNVKSELEMAQEDLSMTQKDK 1346
Score = 50.1 bits (118), Expect = 5e-06
Identities = 47/220 (21%), Positives = 98/220 (44%), Gaps = 27/220 (12%)
Query: 315 HQDELGRMSEDLE---DELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGL 371
HQD+ ++ ++ D + + S++ AE + EM ++ E G+ E L E
Sbjct: 372 HQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQA 431
Query: 372 ERENKKLRAQVGDLEEAL------ARRRRQTASALDCDLRASQAALFEKNKELADLKHVH 425
+E +L+AQ+ L L + +Q +L ++ + + ++ + + DL+++
Sbjct: 432 LKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNM- 490
Query: 426 GKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQ 485
+ K A LA +N ++ E + ++L +VE++++ + ++ + + Q LQ
Sbjct: 491 ------LEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQ 544
Query: 486 RSLDEQTEQSENLQVQLEH--LQSRLRRQQQNAPLFGKIR 523
L QVQLE L S+L+ Q +R
Sbjct: 545 SQLQ---------QVQLERTTLTSKLKASQAEISSLQSVR 575
Score = 49.7 bits (117), Expect = 7e-06
Identities = 49/247 (19%), Positives = 104/247 (42%), Gaps = 19/247 (7%)
Query: 270 REDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDE 329
+E+ L + + +LEG+L ++ + K K E+ Q +L +S L+ +
Sbjct: 404 QEEMLQVLKEKMRLEGQLEALSLEASQALKEKAEL-----------QAQLAALSTKLQAQ 452
Query: 330 LGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEAL 389
+ S ++ L E++ L+ + W + + LE +N L + DL+ A
Sbjct: 453 VECSHSSQQRQDSLSSEVDTLK---QSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAE 509
Query: 390 ARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQH 449
+ +R A D Q ++ K+ + DL+ L+ Q Q+ E +++
Sbjct: 510 EQYQRLMAKVED-----MQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKAS 564
Query: 450 EAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRL 509
+AE+ L+ + +++LA A++ + +Q Q E+L+++ L +L
Sbjct: 565 QAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQL 624
Query: 510 RRQQQNA 516
Q +
Sbjct: 625 TETQHRS 631
Score = 35.8 bits (81), Expect = 0.10
Identities = 75/349 (21%), Positives = 129/349 (36%), Gaps = 55/349 (15%)
Query: 110 KVRAERNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQ 169
+V+A R EE RQ++ + AL L + + + + A E
Sbjct: 1155 QVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGH---------- 1204
Query: 170 TRDGPEPEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSS 229
R + E +EL+ E L++ + E++D R
Sbjct: 1205 ---------NRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQI---------REGK 1246
Query: 230 GRQERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQ 289
QE ++ A E ++L L+ +LDE ++ L +++ E E+
Sbjct: 1247 HSQEIAQFQ----AELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS 1302
Query: 290 WKIKYEELSKTKQEMLKQLSILKEAHQD---ELGRMSEDLEDELGARSSMDRKMAELRGE 346
K ++L T+Q+ K+L L++ Q+ EL EDL + + K++EL+
Sbjct: 1303 LK---QQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNN 1359
Query: 347 MERLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRA 406
M+ L +N + KL L R K R + EA + DC + A
Sbjct: 1360 MKTLLQQN----------QQLKLDLRRGAAKTRKE--PKGEASSSNPATPIKIPDCPVPA 1407
Query: 407 SQAALFEK--NKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEV 453
S L E+ A K L Q+ E+ R++E+H V
Sbjct: 1408 S---LLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHALTV 1453
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 86.3 bits (212), Expect = 7e-17
Identities = 114/500 (22%), Positives = 214/500 (42%), Gaps = 67/500 (13%)
Query: 68 DWESREELRLRELEEARARAAQMEKTMRR-------WSDCTANWREKWSKVRAERNRARE 120
++ E+LR REL E R + + ++ RR + WR++ + +R E + +E
Sbjct: 203 EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262
Query: 121 E----VRQLRQRLDALTK-ELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPE 175
E R+L++ + L K E RRERQE + + + R R +LR R ++ R+ E
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQ-QQRLRREQQLR--RKQEEERREQQE 319
Query: 176 PEAEREPVRDVGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERS 235
E++ R+ ER E E + + E E+ E R + R+++
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEE--ERREQQLRREQEEERREQQL 377
Query: 236 R----LPWEDTAATEEEASKLTALR--------------LRLDESQKVLLKEREDKLALS 277
R L E E++ + LR +L Q++ ++ E++
Sbjct: 378 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQK 437
Query: 278 RNIEKLEGELSQ-------WKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDEL 330
E+ E L + W + EE + +QE KQ LK ++E LE+E
Sbjct: 438 HEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ--LKRDQEEERRERWLKLEEE- 494
Query: 331 GARSSMDRKMAELRGEMERLQAENAAEWGRRERLE-----TEKLGLERENKKLRAQVGDL 385
R +R+ +LR E E + + ERL+ ++L E+E ++ + +
Sbjct: 495 ERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE 554
Query: 386 EEALARRRRQTASALDCDLRASQAALFEKNKELADLK-----HVHGKLKKQFQEKVAELA 440
E+ L + RR+ + + R Q E+ + LK + +LK++ E++ +
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEE 614
Query: 441 HANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQ----TEQSE 496
+R+++ E E EE +++L ++E++ + Q R+ Q+ EQ E+ E
Sbjct: 615 RREQRLKREEPE--------EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666
Query: 497 NLQVQLEHLQSRLRRQQQNA 516
L+ +L+ RR+Q+ A
Sbjct: 667 RLEQRLKREHEEERREQELA 686
Score = 76.3 bits (186), Expect = 7e-14
Identities = 114/493 (23%), Positives = 205/493 (41%), Gaps = 64/493 (12%)
Query: 81 EEARARAAQMEKTM--RRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDALTKELAG 138
EE RAR E + RR + + + ++ E + R + RQ ++R + E
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER-ELAEGEEQS 155
Query: 139 ARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVG---SERPPGSQ 195
++ER E Q + + R EL R R + ++ E AE E ++ +E P +
Sbjct: 156 EKQERLE-QRDRQRRDEELWRQR------QEWQEREERRAEEEQLQSCKGHETEEFPDEE 208
Query: 196 EL---ELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWEDTAATEEEASKL 252
+L EL+E K E+ + E + R+ + L E+ EEE +
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQ 268
Query: 253 TALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILK 312
L+ +E +++ ER++ L R E+ E E Q +++ E+ + KQE ++ +
Sbjct: 269 RELQ---EEEEQLRKLERQE---LRR--ERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320
Query: 313 EAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLE 372
Q E E+ ++ R +R+ +LR E E + E RRE+ E +
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQL---RREQEEERREQQL 377
Query: 373 RENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQF 432
R ++LR + E RR +Q LR Q E+ +L+++
Sbjct: 378 RREQQLRREQQLRREQQLRREQQ--------LRREQQLRREQQLRREQQLRREQQLRREQ 429
Query: 433 QEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQR------ 486
+E+ R ++HE E ++ RL+ E+ ++ +E E H Q R+ Q+
Sbjct: 430 EEE--------RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE 481
Query: 487 ----------SLDEQTEQSENLQVQL-----EHLQSRLRRQQQNAPLFGKIRSARFGTEE 531
+E+ EQ E + QL E + RL+RQ++ L ++RS + E
Sbjct: 482 EERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 532 AEDGTSDLDEDED 544
E+ L + E+
Sbjct: 542 QEERREQLLKREE 554
Score = 70.9 bits (172), Expect = 3e-12
Identities = 125/509 (24%), Positives = 209/509 (41%), Gaps = 67/509 (13%)
Query: 72 REELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRA--------------ERNR 117
R E L+ EE RA Q E+ RR D T W+ + R ER
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQRR--DFTWQWQAEEKSERGRQRLSARPPLREQRERQL 798
Query: 118 AREEVRQLRQRLDALTKELAGARRERQEAQGECEARGRE--LARLRGARGVADQTRDGPE 175
EE +Q QR +E RR+R+E + E + E L R A+ + ++ DG +
Sbjct: 799 RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE-EDGLQ 857
Query: 176 PEAER----EPVRD------VGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGP 225
+ ER E RD + ER L +L + + +E + E
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 226 RGSSGRQERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEG 285
R RQE+ R E+ +EE L +E +K +ERE + + +++ E
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLR------EEREKRRRQERERQYRKDKKLQQKEE 971
Query: 286 ELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGAR-SSMDRKMAELR 344
+L + E + +QE K+ +E Q+E + E+ E RK EL+
Sbjct: 972 QL----LGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ 1027
Query: 345 GEMERLQAENAAE--WGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDC 402
E E+L E + RER E+ L++E ++L +G+ E R+ + +
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQL---LGEERETRRRQELERQYRKEE 1084
Query: 403 DLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEE 462
+L+ + L + E K + ++Q +E+ EL ++ + E E K+ R +E
Sbjct: 1085 ELQQEEEQLLREEPE----KRRRQERERQCREE-EELQQEEEQLLREERE-KRRRQELER 1138
Query: 463 L---KKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHL---------QSRLR 510
++E+ Q E++L + R+ Q L+ Q + E LQ + E L Q R R
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQ-ELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Query: 511 RQQQNAPLFGKIRSARFGTEEAEDGTSDL 539
+ ++ L + R R+ ED SDL
Sbjct: 1198 QYREEEELQRQKRKQRY---RDEDQRSDL 1223
Score = 68.6 bits (166), Expect = 1e-11
Identities = 110/477 (23%), Positives = 207/477 (43%), Gaps = 66/477 (13%)
Query: 70 ESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRL 129
+ REE +L E R + + E+ +RR +E+ K R + R++E R+ +
Sbjct: 1471 QEREEQQLHRQERDR-KFLEEEQQLRR--------QERDRKFREQELRSQEPERKFLEEE 1521
Query: 130 DALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVGSE 189
L ++ +R+R+ Q E + R +E RG + D+ R E E R+ +
Sbjct: 1522 QQLHRQ----QRQRKFLQEEQQLRRQE----RGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 190 RPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSG----RQERSRLPWEDTAAT 245
R ++ L E ++ +E + + + L R G RQER R ED
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQL-----RRQEGQQQLRQERDRKFREDEQLL 1628
Query: 246 EEEASKLTALRLR----LDESQKVLLKEREDKLALSRNI-----EKLEGELSQWKIKYEE 296
+E + + R L+E ++ +ERE +L R+ E+L E + +++ +E
Sbjct: 1629 QEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQE 1688
Query: 297 LSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAE---LRGEMERLQAE 353
+ +E +QL + E R E +L R ++RK E LR E E+ Q
Sbjct: 1689 RDRKFREEEQQL------RRQERERKFLQEEQQL-RRQELERKFREEEQLRQETEQEQLR 1741
Query: 354 NAAEWGRRERLETEKLGLERENKKLRAQVGDL-----EEALARRRRQTASALDCDLRASQ 408
+ R+ LE E+L ERE ++LR Q D E+ R Q + + D + +
Sbjct: 1742 RQERY--RKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE 1799
Query: 409 AALFEKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELA 468
+ +E L+ K +++E EQ + E ++ RLR E ++ A
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEE------------EQLQLEEQEQRLRQERDRQYRA 1847
Query: 469 QAEDELDE-AHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRS 524
+ + E + + ++L + +++ Q +++ EH++ R ++++Q G+I+S
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIR-RQQKEEQRHRQVGEIKS 1903
Score = 66.6 bits (161), Expect = 6e-11
Identities = 117/513 (22%), Positives = 205/513 (39%), Gaps = 80/513 (15%)
Query: 68 DWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQ 127
DW REE R +E R + + ++ R RE+W K+ E R ++E R+ Q
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEER--------RERWLKLEEEERREQQERRE--Q 505
Query: 128 RLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRDVG 187
+L +E R +RQE + + R R +LR R ++ + E E+ ++
Sbjct: 506 QLRREQEERREQRLKRQEEEERLQQRLRSEQQLR--REQEERREQLLKREEEKRLEQERR 563
Query: 188 SERPPGSQELELVESLLKSMPE--------ESEDCWEARSLGAGGPRGSSGRQERSRLPW 239
+R QE E + LLK E E E+ E R R + RL
Sbjct: 564 EQRLKREQE-ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR 622
Query: 240 EDTA---------ATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNI------EKLE 284
E+ + E+E + LR E ++ LK E++ L + + E+ E
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682
Query: 285 GELS------------------QWKIKYE---ELSKTKQEMLKQLSILKEAHQDELGRMS 323
EL+ QW+++ E SK KQ + Q+E R
Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742
Query: 324 E-DLEDELGARSSMDRKMAELRGEME-RLQAENAAEWGRRERLETEKLGLERENKKLRAQ 381
E +L+ + R+ ++ E R + + QAE +E GR +RL E+ ++LRA+
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR-QRLSARPPLREQRERQLRAE 801
Query: 382 ---------VGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQF 432
+ + EE RRR++ + + L + + + G + Q
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Query: 433 QEKVAELAHANRRVEQHEAEVKKLRLRV-------EELKKELAQAEDELDEAHNQARKLQ 485
+ + E + Q E E K+ R + E+L+KE ++E +E + R+ +
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKR 921
Query: 486 RSLDEQTEQSENLQVQLEHLQ----SRLRRQQQ 514
R +++ + E Q+Q E Q R +R++Q
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Score = 63.2 bits (152), Expect = 6e-10
Identities = 113/481 (23%), Positives = 197/481 (40%), Gaps = 58/481 (12%)
Query: 63 LLADGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREK--------WSKVRAE 114
L D + E RE E EE R + + E+ +RR + R K ++R+E
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 115 RNRAREEVRQLRQRLDALTKELAGARRERQEAQGECEARGRELARL---RGARGVADQTR 171
+ RE+ + Q L ++ R Q + E E R +L + R + + +
Sbjct: 536 QQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE 595
Query: 172 DGPEPEAEREPVRDVGSERPPGSQ------ELELVESLLKSMPEESEDCWEARSLGAGGP 225
+ E +RE V + E + E E + LLKS +E + R
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR------- 648
Query: 226 RGSSGRQERSRLPWEDTAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEG 285
R R+E+ RL E+ EEE + R +E ++ L E E + A E+++
Sbjct: 649 REQQERREQ-RLKREE----EEERLEQRLKREHEEERREQELAEEEQEQAR----ERIKS 699
Query: 286 ELSQWKIKYEELSKTKQEML-----KQLSILKEAHQDELGRMSE-DLEDELGARSSMDRK 339
+ +W+ + E + +Q + KQ + Q+E R E +L+ + R+ ++
Sbjct: 700 RIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQ 759
Query: 340 MAELRGEME-RLQAENAAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTAS 398
E R + + QAE +E G R+RL E+ ++LRA EE R +R
Sbjct: 760 EEEQRRDFTWQWQAEEKSERG-RQRLSARPPLREQRERQLRA-----EERQQREQRFLPE 813
Query: 399 ALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAE-----LAHANRRVEQHEAEV 453
+ + R Q E+ KEL L+ +++ +++ E RR Q +
Sbjct: 814 EEEKEQRRRQRR--EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 454 KKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQ 513
+K R ++EE +K Q RK Q+ L E+ E ++Q E + R R++Q
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE-----ELQREEREKRRRQEQ 926
Query: 514 Q 514
+
Sbjct: 927 E 927
Score = 61.2 bits (147), Expect = 2e-09
Identities = 118/527 (22%), Positives = 203/527 (38%), Gaps = 66/527 (12%)
Query: 70 ESREELRLRELEEARARAA----------QMEKTMRRWSDCTANWREKWSKVRAERNRAR 119
+ EE LRE +E R + Q +K +R+ D KW + N R
Sbjct: 1177 QQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVR 1236
Query: 120 EEVRQLRQRLDALTKELAGAR-RERQEAQ------GECEARGRELARLRGARGVADQTRD 172
+ + R + ++L ++ R+RQ Q GE + R RE R R + + R
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQ----RDRH 1292
Query: 173 GPEPEA-EREPVRDVGSERPPGSQELELV--ESLLKSMPEESEDCW-EARSLGAGGPRGS 228
PE E ERE ++ +E +L+ E K +E++ + E L
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Query: 229 SGRQERSRLPWEDTAATEEEASKLTA--LRLRLDESQKVLLKE----------------- 269
RQER R E+ +E+ K RLR E ++ LKE
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412
Query: 270 ----REDKLALSRNIEKLEGELSQWKIKYEELSKTKQEMLKQLSILKEAHQDELGRMSED 325
RE++ LSR + + +++ +E + E +QL + E ++ ++
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Query: 326 LEDELGARSSMDRKMAELRGEMERLQAENAAEWGRRERLETEKLGLERENKKLRAQ---- 381
E++ R DRK E ++ R + + E E+ LE E + R Q
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRK 1532
Query: 382 VGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADLKHVHGKLKKQFQEKVAELAH 441
E+ L R+ R D D + + + +E L K + +E+
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592
Query: 442 ANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQARKLQRSLDEQTEQSENLQVQ 501
R+ + E + LR +E +++L Q D + + LQ ++Q + E +
Sbjct: 1593 QERKFMEDEQQ-----LRRQEGQQQLRQERDR--KFREDEQLLQEREEQQLHRQERDRKF 1645
Query: 502 LEHLQSRLRRQQQNAPLFGKIRSARFGTEEAEDGTSDLDEDEDLQIQ 548
LE + +LRRQ++ L R +F EE L E E+ Q++
Sbjct: 1646 LEE-EPQLRRQEREQQL-RHDRDRKFREEE-----QLLQEGEEQQLR 1685
Score = 60.8 bits (146), Expect = 3e-09
Identities = 109/485 (22%), Positives = 197/485 (40%), Gaps = 48/485 (9%)
Query: 70 ESREELRLRELEEA---RARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLR 126
E RE+ R +ELE Q E+ + R +E + R E +EE + LR
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Query: 127 QRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGP---EPEAEREPV 183
+ + +E RERQ + E R + R R DQ D EPE E V
Sbjct: 1186 EEQEKRRQE-----RERQYREEEELQRQKRKQRYRD----EDQRSDLKWQWEPEKE-NAV 1235
Query: 184 RD--VGSERPPGSQELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWED 241
RD V + Q +L +S L+ + +D G + QER R D
Sbjct: 1236 RDNKVYCKGRENEQFRQLEDSQLRDR-QSQQDLQHL----LGEQQERDREQERRRWQQRD 1290
Query: 242 TAATEE-----EASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEE 296
EE E K R R + +K LL+E ++ + ++ E Q + EE
Sbjct: 1291 RHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE 1350
Query: 297 LSKTKQEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAEN-- 354
+QE ++ + HQ++ + E E++ R +RK + ++ + E
Sbjct: 1351 QPLRRQERDRKFREEELRHQEQGRKFLE--EEQRLRRQERERKFLKEEQQLRCQEREQQL 1408
Query: 355 AAEWGRRERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCD--LRASQAALF 412
+ R+ R E ++L + ++K R EE RR+ + L+ + LR + F
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFRE-----EEQQVRRQERERKFLEEEQQLRQERHRKF 1463
Query: 413 EKNKELADLKHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAED 472
+ ++L + +++ K E RR ++ + + ++ LR +E +++ + E
Sbjct: 1464 REEEQLLQEREEQQLHRQERDRKFLEEEQQLRR-QERDRKFREQELRSQEPERKFLEEEQ 1522
Query: 473 ELDEAHNQARKLQRSLDEQTEQSENLQVQLE------HLQSRLRRQQQNAPLFGKIRSAR 526
+L Q + LQ ++Q + E Q + + + +LR++++ L + R +
Sbjct: 1523 QLHRQQRQRKFLQE--EQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580
Query: 527 FGTEE 531
F EE
Sbjct: 1581 FRLEE 1585
Score = 60.1 bits (144), Expect = 5e-09
Identities = 104/490 (21%), Positives = 189/490 (38%), Gaps = 61/490 (12%)
Query: 72 REELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQLRQRLDA 131
REE R +E + + +K ++ EK + R ER + E +L+Q +
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK--RRRQEREKKYREEEELQQEEEQ 1002
Query: 132 LTKELAGARR----ERQ-----EAQGECEARGRELARLRGARGVADQTRDGPEPEAEREP 182
L +E RR ERQ E Q E E RE R + Q R+ E + E E
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062
Query: 183 VRDVGSERPPGS-QELELVESLLKSMPEESEDCWEARSLGAGGPRGSSGRQERSRLPWED 241
+ +G ER QELE + + +E E +E L E+
Sbjct: 1063 L--LGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120
Query: 242 TAATEEEASKLTALRLRLDESQKVLLKEREDKLALSRNIEKLEGELSQWKIKYEELSKTK 301
EE K L ++ +++ E++L ++ EL + + EEL + +
Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180
Query: 302 QEMLKQLSILKEAHQDELGRMSEDLEDELGARSSMDRKMAELRGEMERLQAENAAEWGRR 361
+++L++ + ++ R E+L+ R+ + R E +++ +W
Sbjct: 1181 EQLLREEQEKRRQERERQYREEEELQ----------RQKRKQRYRDEDQRSDLKWQW--- 1227
Query: 362 ERLETEKLGLERENKKLRAQVGDLEEALARRRRQTASALDCDLRASQAALFEKNKELADL 421
E EK R+NK R Q D LR Q+ DL
Sbjct: 1228 ---EPEKENAVRDNKVY---------CKGRENEQFRQLEDSQLRDRQSQ--------QDL 1267
Query: 422 KHVHGKLKKQFQEKVAELAHANRRVEQHEAEVKKLRLRVEELKKELAQAEDELDEAHNQA 481
+H+ G+ +++ +E+ R E ++++ + + + +Q E +L +
Sbjct: 1268 QHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327
Query: 482 RKLQRSLDEQTEQSENLQVQLEHLQSRLRRQQQNAPLFGKIRSARFGTEE---AEDGTSD 538
++ ++ D + + E L + E + LRRQ+ R +F EE E G
Sbjct: 1328 KRRRQETDRKFREEEQLLQERE--EQPLRRQE---------RDRKFREEELRHQEQGRKF 1376
Query: 539 LDEDEDLQIQ 548
L+E++ L+ Q
Sbjct: 1377 LEEEQRLRRQ 1386
Score = 34.3 bits (77), Expect = 0.30
Identities = 41/152 (26%), Positives = 63/152 (41%), Gaps = 12/152 (7%)
Query: 66 DGDWESREELRLRELEEARARAAQMEKTMRRWSDCTANWREKWSKVRAERNRAREEVRQL 125
+ D + REE +LR+ E + Q RW + E+ ++R ER+ RQ
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD------RQY 1845
Query: 126 RQRLDALTKELAGARRERQEAQGECEARGRELARLRGARGVADQTRDGPEPEAEREPVRD 185
R T+E +RRE QE E E + R+ R R R + R + E V +
Sbjct: 1846 RAEEQFATQE--KSRREEQELWQEEEQKRRQ-ERERKLR--EEHIRRQQKEEQRHRQVGE 1900
Query: 186 VGSERPPG-SQELELVESLLKSMPEESEDCWE 216
+ S+ G + LE S+P S +E
Sbjct: 1901 IKSQEGKGHGRLLEPGTHQFASVPVRSSPLYE 1932
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.127 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,590,683
Number of Sequences: 37866
Number of extensions: 1321297
Number of successful extensions: 32550
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 927
Number of HSP's successfully gapped in prelim test: 1527
Number of HSP's that attempted gapping in prelim test: 13589
Number of HSP's gapped (non-prelim): 12084
length of query: 550
length of database: 18,247,518
effective HSP length: 107
effective length of query: 443
effective length of database: 14,195,856
effective search space: 6288764208
effective search space used: 6288764208
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.