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Search of human proteins with 225579095
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|225579095 S-phase cyclin A-associated protein in the ER
isoform b [Homo sapiens]
(1154 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|225579095 S-phase cyclin A-associated protein in the ER isofo... 2280 0.0
gi|225579092 S-phase cyclin A-associated protein in the ER isofo... 2257 0.0
gi|148746195 trichohyalin [Homo sapiens] 96 2e-19
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 92 2e-18
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 92 2e-18
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 91 8e-18
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 91 8e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 89 3e-17
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 88 5e-17
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 88 5e-17
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 87 9e-17
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 87 9e-17
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 87 1e-16
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 86 2e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 82 3e-15
gi|219803769 trichoplein [Homo sapiens] 81 5e-15
gi|14150056 trichoplein [Homo sapiens] 81 5e-15
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 80 9e-15
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 78 4e-14
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 78 4e-14
gi|221219020 NYD-SP11 protein [Homo sapiens] 78 6e-14
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 77 7e-14
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 77 7e-14
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 77 7e-14
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 77 7e-14
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 77 7e-14
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 77 7e-14
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 77 7e-14
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 77 7e-14
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 77 1e-13
>gi|225579095 S-phase cyclin A-associated protein in the ER isoform b
[Homo sapiens]
Length = 1154
Score = 2280 bits (5909), Expect = 0.0
Identities = 1154/1154 (100%), Positives = 1154/1154 (100%)
Query: 1 MKTKYIFCNITERKDAEGWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDSDKENVCLL 60
MKTKYIFCNITERKDAEGWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDSDKENVCLL
Sbjct: 1 MKTKYIFCNITERKDAEGWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDSDKENVCLL 60
Query: 61 PDESIQKGQFVGDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNYVR 120
PDESIQKGQFVGDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNYVR
Sbjct: 61 PDESIQKGQFVGDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNYVR 120
Query: 121 TSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKE 180
TSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKE
Sbjct: 121 TSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKE 180
Query: 181 ELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGM 240
ELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGM
Sbjct: 181 ELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGM 240
Query: 241 SMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKK 300
SMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKK
Sbjct: 241 SMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKK 300
Query: 301 HEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKRE 360
HEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKRE
Sbjct: 301 HEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKRE 360
Query: 361 VQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEK 420
VQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEK
Sbjct: 361 VQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEK 420
Query: 421 QARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREE 480
QARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREE
Sbjct: 421 QARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREE 480
Query: 481 RLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
RLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT
Sbjct: 481 RLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
Query: 541 PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYII 600
PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYII
Sbjct: 541 PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYII 600
Query: 601 DIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ 660
DIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ
Sbjct: 601 DIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ 660
Query: 661 RLAKDLLKQVQVQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHI 720
RLAKDLLKQVQVQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHI
Sbjct: 661 RLAKDLLKQVQVQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHI 720
Query: 721 LQAVVPATNVNTVLRIPPKSLCNAINVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLT 780
LQAVVPATNVNTVLRIPPKSLCNAINVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLT
Sbjct: 721 LQAVVPATNVNTVLRIPPKSLCNAINVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLT 780
Query: 781 VYVPDENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMK 840
VYVPDENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMK
Sbjct: 781 VYVPDENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMK 840
Query: 841 NKPSQGDPFNNRVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAM 900
NKPSQGDPFNNRVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAM
Sbjct: 841 NKPSQGDPFNNRVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAM 900
Query: 901 CTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLHMLYCVLFHGTILDPSTASPKE 960
CTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLHMLYCVLFHGTILDPSTASPKE
Sbjct: 901 CTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLHMLYCVLFHGTILDPSTASPKE 960
Query: 961 NYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESL 1020
NYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESL
Sbjct: 961 NYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESL 1020
Query: 1021 LHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACY 1080
LHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACY
Sbjct: 1021 LHEVIVCVGYFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACY 1080
Query: 1081 NNHQNKIILEQEMSCVLLATFIQDLAQTPGQAENQPYQPKGKCLGSQDYLELANRFPQQA 1140
NNHQNKIILEQEMSCVLLATFIQDLAQTPGQAENQPYQPKGKCLGSQDYLELANRFPQQA
Sbjct: 1081 NNHQNKIILEQEMSCVLLATFIQDLAQTPGQAENQPYQPKGKCLGSQDYLELANRFPQQA 1140
Query: 1141 WEEARQFFLKKEKK 1154
WEEARQFFLKKEKK
Sbjct: 1141 WEEARQFFLKKEKK 1154
>gi|225579092 S-phase cyclin A-associated protein in the ER isoform a
[Homo sapiens]
Length = 1400
Score = 2257 bits (5848), Expect = 0.0
Identities = 1143/1143 (100%), Positives = 1143/1143 (100%)
Query: 12 ERKDAEGWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDSDKENVCLLPDESIQKGQFV 71
ERKDAEGWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDSDKENVCLLPDESIQKGQFV
Sbjct: 258 ERKDAEGWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDSDKENVCLLPDESIQKGQFV 317
Query: 72 GDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNYVRTSEISAVHIDT 131
GDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNYVRTSEISAVHIDT
Sbjct: 318 GDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNYVRTSEISAVHIDT 377
Query: 132 ECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANE 191
ECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANE
Sbjct: 378 ECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANE 437
Query: 192 EAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADY 251
EAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADY
Sbjct: 438 EAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADY 497
Query: 252 EARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQL 311
EARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQL
Sbjct: 498 EARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQL 557
Query: 312 REKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ 371
REKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ
Sbjct: 558 REKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ 617
Query: 372 EEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERK 431
EEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERK
Sbjct: 618 EEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERK 677
Query: 432 RALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQE 491
RALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQE
Sbjct: 678 RALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQE 737
Query: 492 AMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLC 551
AMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLC
Sbjct: 738 AMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLC 797
Query: 552 NVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAE 611
NVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAE
Sbjct: 798 NVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAE 857
Query: 612 ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQ 671
ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQ
Sbjct: 858 ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQ 917
Query: 672 VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHILQAVVPATNVN 731
VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHILQAVVPATNVN
Sbjct: 918 VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHILQAVVPATNVN 977
Query: 732 TVLRIPPKSLCNAINVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLTVYVPDENNTIL 791
TVLRIPPKSLCNAINVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLTVYVPDENNTIL
Sbjct: 978 TVLRIPPKSLCNAINVYNLTCNNCSENCSDVLFSNKITFLMDLLIHQLTVYVPDENNTIL 1037
Query: 792 GRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMKNKPSQGDPFNN 851
GRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMKNKPSQGDPFNN
Sbjct: 1038 GRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMKNKPSQGDPFNN 1097
Query: 852 RVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAMCTLCFAVTGRS 911
RVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAMCTLCFAVTGRS
Sbjct: 1098 RVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAMCTLCFAVTGRS 1157
Query: 912 YSIFDNNRQDPTGLTAALQATDLAGVLHMLYCVLFHGTILDPSTASPKENYTQNTIQVAI 971
YSIFDNNRQDPTGLTAALQATDLAGVLHMLYCVLFHGTILDPSTASPKENYTQNTIQVAI
Sbjct: 1158 YSIFDNNRQDPTGLTAALQATDLAGVLHMLYCVLFHGTILDPSTASPKENYTQNTIQVAI 1217
Query: 972 QSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESLLHEVIVCVGYF 1031
QSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESLLHEVIVCVGYF
Sbjct: 1218 QSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESLLHEVIVCVGYF 1277
Query: 1032 TVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACYNNHQNKIILEQ 1091
TVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACYNNHQNKIILEQ
Sbjct: 1278 TVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACYNNHQNKIILEQ 1337
Query: 1092 EMSCVLLATFIQDLAQTPGQAENQPYQPKGKCLGSQDYLELANRFPQQAWEEARQFFLKK 1151
EMSCVLLATFIQDLAQTPGQAENQPYQPKGKCLGSQDYLELANRFPQQAWEEARQFFLKK
Sbjct: 1338 EMSCVLLATFIQDLAQTPGQAENQPYQPKGKCLGSQDYLELANRFPQQAWEEARQFFLKK 1397
Query: 1152 EKK 1154
EKK
Sbjct: 1398 EKK 1400
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 95.9 bits (237), Expect = 2e-19
Identities = 96/401 (23%), Positives = 190/401 (47%), Gaps = 46/401 (11%)
Query: 255 ESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPS----RKRTIAESKKK-HEEKQMKAQ 309
E WRQ W + E HE P R+R + E ++K EEKQ + +
Sbjct: 172 ELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRR 231
Query: 310 QLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKK 369
+ ++++ +E+ K + +RE +RK +E+L ++ + E E R+++ Q + ++
Sbjct: 232 ERQDRVFQEEEEKEWR--KRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 370 AQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQE 429
QEEE + + +R L + +E E+R E QEER+ +QE ++ ++E
Sbjct: 290 RQEEEQQQQRL----------RREQQLRRKQEEERR--EQQEERREQQERREQQEE---R 334
Query: 430 RKRALEAERQARVEELLMKRKEQEARIEQQ---RQEKEKAREDAARERARDREERLAALT 486
R++ L E++ R E+ L +R+++E R EQQ QE+E+ + RE+ RE++L
Sbjct: 335 REQQLRREQEERREQQL-RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 487 AAQQEAMEELQKKIQLKHDESIRRHME---QIEQRKEKAAELSSGRHANTDYAPKLTPYE 543
++E ++L+++ QL+ ++ +RR + + + R+E+ E +H +L +
Sbjct: 394 QLRRE--QQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 544 RKKQCSLCNVLISSEVYLFSHVKGRKHQQAVR-ENTSIQGRELSDEEVEHLSLKKYIIDI 602
+++ L E H + R+ QQ R + + R L EE E
Sbjct: 452 EERRDWL-----KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE-------- 498
Query: 603 VVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESL 643
+ + ++ EER++ + K ++ + R+ R + + L
Sbjct: 499 -QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Score = 95.9 bits (237), Expect = 2e-19
Identities = 109/532 (20%), Positives = 224/532 (42%), Gaps = 90/532 (16%)
Query: 145 LQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQL 204
L+ EEK E+ + + E+ + E L K E R E+ EE + E+QL
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEE------EQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 205 TREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWG 264
R+ E E E RE +
Sbjct: 307 RRKQEEERREQ----------------------------------QEERREQQERREQQE 332
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ 324
+ E++ R E+ R+ E +++ ++ + ++ ++LR E+ L+ +
Sbjct: 333 ERREQQLRR------EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386
Query: 325 KLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFIN 384
+ L RE+ +R+ ++ +Q+ R ++ + +RE QL+ ++ + E+ E
Sbjct: 387 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR 446
Query: 385 TLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARD-----------EAVQERKRA 433
Q +R D L + +E E+ E ++++ +R +E++ R+ E + R++
Sbjct: 447 LKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506
Query: 434 LEAERQARVEELLMKRKEQEARIEQQ-------RQEKEKAREDAAR---ERARDREERLA 483
L E++ R E+ L KR+E+E R++Q+ R+E+E+ RE + E+ ++E R
Sbjct: 507 LRREQEERREQRL-KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQ 565
Query: 484 ALTAAQQEAMEELQKKIQLKHDESIRRHMEQ-IEQR-KEKAAELSSGRHANTDYAPKLTP 541
L Q+E ++L K+ + + + ++R E+ +EQR K + E + P
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP 625
Query: 542 YERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIID 601
E ++Q L+ SE + R+ QQ RE + + L EE E
Sbjct: 626 EEERRQ-----QLLKSE-----EQEERRQQQLRREQQERREQRLKREEEEER-------- 667
Query: 602 IVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDS 653
+E E ++ E++ +++ ++ + R+ R +++ +E++ S
Sbjct: 668 --LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717
Score = 85.5 bits (210), Expect = 3e-16
Identities = 94/427 (22%), Positives = 189/427 (44%), Gaps = 33/427 (7%)
Query: 247 VLADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQM 306
+L D E R+ +EEEP + + ++R +AE +++ E+++
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQ--------RRRQKRQEQERELAEGEEQSEKQER 160
Query: 307 KAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAI 366
Q+ R++ EE + Q+ ERE+ R+ +EE L + E+ E R +L +
Sbjct: 161 LEQRDRQRRDEELWRQRQEWQEREE--RRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL 218
Query: 367 VKKAQEEEAKVNEIAFINTLEAQN-----KRHDVLSKLKEYEQRLNELQEERQRRQEEKQ 421
+K +EE+ + + + KR VL K +E +LQEE +RQ E Q
Sbjct: 219 RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE------KLQEEEPQRQRELQ 272
Query: 422 ARDEAVQERKR-ALEAERQARVEELLMKRKEQEAR--IEQQRQEKEKAREDAARERARDR 478
+E +++ +R L ERQ ++ R+EQ+ R E++R+E+++ R + R +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 479 EERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPK 538
E R L Q+E E+ ++ Q + + EQ E+R+E+ +L + + +
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ--QLRREQQLRREQQLR 390
Query: 539 LTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKY 598
R++Q + E L + R+ QQ RE + + ++E LK+
Sbjct: 391 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR- 449
Query: 599 IIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAK 658
E + LK EE ++++++ +K + + + + E ++ + + +
Sbjct: 450 ------EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Query: 659 LQRLAKD 665
Q+L ++
Sbjct: 504 EQQLRRE 510
Score = 85.1 bits (209), Expect = 3e-16
Identities = 83/285 (29%), Positives = 139/285 (48%), Gaps = 55/285 (19%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLRE----KLREEKTL----KLQKLLEREKDVR 334
++L R R E + + +Q + QQLR K REE+ L + Q+L +E+D R
Sbjct: 1634 QQLHRQERDRKFLEEEPQLR-RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD-R 1691
Query: 335 KWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHD 394
K++EE RR+ E K L E ++++ Q + +K +EEE E T + Q +R +
Sbjct: 1692 KFREEEQQLRRQERERKFLQEE--QQLRRQELERKFREEEQLRQE-----TEQEQLRRQE 1744
Query: 395 VLSKLKEYEQRLNELQEERQRRQE-------EKQARDEAVQERKRALEAERQARVEELLM 447
K+ E EQ E +E++ RRQE E+Q R E +++ R+ E++R+ R EE L
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804
Query: 448 KRKE------------------------QEARIEQQRQEKEKARED-AARERARDREERL 482
+ +E QE R+ Q+R + +A E A +E++R E+ L
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQEL 1864
Query: 483 AALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSS 527
Q+E + Q++ + +E IRR ++ EQR + E+ S
Sbjct: 1865 -----WQEEEQKRRQERERKLREEHIRRQQKE-EQRHRQVGEIKS 1903
Score = 83.2 bits (204), Expect = 1e-15
Identities = 73/280 (26%), Positives = 138/280 (49%), Gaps = 16/280 (5%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELL- 341
E+L +K +K EEKQ+ ++ EK R ++T + K E E+ +++ +E+ L
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR--KFREEEQLLQEREEQPLR 1354
Query: 342 --DQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAK-VNEIAFINTLEAQNK-RHDVLS 397
++ R+ EE+L H E R+ + + QE E K + E + E + + R D
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414
Query: 398 KLKEYEQRLNELQEERQRRQEEKQARDEA------VQERKRALEAERQARVEELLMKRKE 451
K +E EQ+L+ + +R+ R+EE+Q R + +E++ E R+ R EE L++ +E
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE 1474
Query: 452 QEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRH 511
++ Q+R K E R + RDR+ R L +Q+ + L+++ QL + R+
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQEL-RSQEPERKFLEEEQQLHRQQRQRKF 1533
Query: 512 MEQIEQ--RKEKAAELSSGRHANTDYAPKLTPYERKKQCS 549
+++ +Q R+E+ + R +L ++Q S
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Score = 82.4 bits (202), Expect = 2e-15
Identities = 139/645 (21%), Positives = 269/645 (41%), Gaps = 88/645 (13%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMA---EVLAKKEELADRLEKANEEAIASAIAEEE 202
Q+ E+ + R++ E + + + E +++ELA+ ++ E I S I + +
Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQ 705
Query: 203 -QLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADY--EARESWRQ 259
QL E +A ++ + + + W + + + E R+
Sbjct: 706 WQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765
Query: 260 NTSWGDIVEEEP--------ARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQL 311
+ +W EE+ ARPP +L + R++ + EEK+ + +Q
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPPLRE-QRERQLRAEERQQREQRFLPEEEEKEQRRRQR 824
Query: 312 REKLREEKTLKLQKLLEREKDVRKWKEE----LLDQRRRMMEEKLLHAEFKREVQ----- 362
RE+ +E + L+ ++ L+R + ++ +EE DQ RR +E+ +++ +++
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884
Query: 363 ----------LQAIVKKAQ------EEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRL 406
LQ ++K Q EEE + E E + + + +E EQ L
Sbjct: 885 RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 407 NELQEERQRRQEEKQAR-DEAVQ-----------ERKRALEAERQARVEELLMKRKEQEA 454
E +E+R+R++ E+Q R D+ +Q E++R E E++ R EE L ++E+E
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL--QQEEEQ 1002
Query: 455 RIEQQRQ------------EKEKAREDAARERARDREERLAALTAAQQEAMEEL-QKKIQ 501
+ ++R+ +K++ +++ + +RE+R Q EEL Q++ Q
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062
Query: 502 LKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAP-KLTPYERKKQCSLCNVLISSEVY 560
L +E R +++E++ K EL P K ER++QC L E
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 561 LFSHVKGRKHQQAV----RENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDG 616
L + ++ +Q + RE +Q E E++ +K + E L+
Sbjct: 1123 LLREEREKRRRQELERQYREEEEVQQEE---EQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 617 EERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSG 676
EE+ +++ K R R ++Y E + Y+ + QR DL Q + +
Sbjct: 1180 EEQLLREEQEK----RRQERERQYREEEELQRQKRKQRYRDEDQR--SDLKWQWEPEKEN 1233
Query: 677 SWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHIL 721
+ +NKV R E R LE + D+ + Q L+H+L
Sbjct: 1234 AVRDNKVYCKGRE-NEQFRQLEDSQLRDRQSQQ------DLQHLL 1271
Score = 82.0 bits (201), Expect = 3e-15
Identities = 129/567 (22%), Positives = 237/567 (41%), Gaps = 88/567 (15%)
Query: 149 EEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREI 208
EE+ R E E S ++ ++EE ++L K EE E++L RE
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQ 571
Query: 209 EAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVE 268
E + + E + + + E R R + +E
Sbjct: 572 EERRDQLLKREEERRQ--------------------QRLKREQEERLEQRLKREEVERLE 611
Query: 269 EEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQM----KAQQLREK--LREEKTLK 322
+E R + + R++ + +S+++ E +Q + Q+ RE+ REE+ +
Sbjct: 612 QEERREQ----RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667
Query: 323 LQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAF 382
L++ L+RE + + ++EL ++ + E++ K + QL++ +A ++KV +
Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES---EADARQSKV--YSR 722
Query: 383 INTLEAQNKRHDVLSKLKEYEQRLNELQEERQRR--QEEKQARD-------EAVQERKRA 433
E Q +R + K + E L +EER R QEE+Q RD E ER R
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 434 L---------EAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAA 484
+ ERQ R EE R+++E R + +EKE+ R R+R R+RE+ L
Sbjct: 783 RLSARPPLREQRERQLRAEE----RQQREQRFLPEEEEKEQRR----RQR-REREKELQF 833
Query: 485 LTAAQQEAMEELQKKIQ-----LKHDESIRRHMEQIEQRKEK-AAELSSGRHANTDYA-P 537
L +Q E +++Q L+ D+ RR EQ +K + E R +T YA P
Sbjct: 834 LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893
Query: 538 KLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHL---- 593
L RK+Q L+ E + K ++ +E + +L EE + L
Sbjct: 894 ALQEQLRKEQ-----QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948
Query: 594 -------SLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMET 646
++Y D ++ + L + E+++ +++ KK + + +E + L E
Sbjct: 949 EKRRRQERERQYRKDKKLQQ-KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007
Query: 647 KNSGSDSPYKAKLQRLAKDLLKQVQVQ 673
+ ++ + ++ KD L+Q + Q
Sbjct: 1008 REKRRRQEWERQYRK--KDELQQEEEQ 1032
Score = 76.3 bits (186), Expect = 2e-13
Identities = 73/290 (25%), Positives = 133/290 (45%), Gaps = 46/290 (15%)
Query: 291 KRTIAESKKKHEEKQMKAQQLREKLREEKTLKL----QKLLEREKDVRKWKEELLDQRRR 346
+R E K EE+Q++ Q+ ++LR+++ K Q+L +E+D RK++EE RR+
Sbjct: 1384 RRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERD-RKFREEEQQVRRQ 1442
Query: 347 MMEEKLL----------HAEFKREVQL-----------QAIVKKAQEEEAKVNEIAFINT 385
E K L H +F+ E QL Q +K EEE ++
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502
Query: 386 LEAQNKR-HDVLSKLKEYEQRLNE-------LQEERQRRQEEKQARDEAVQERKRALEAE 437
Q R + K E EQ+L+ LQEE+Q R++E+ ++R + +
Sbjct: 1503 FREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER--------GQQRRQDRD 1554
Query: 438 RQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQ 497
R+ R EE L + +E++ Q+R K + E R + ++R+ + QQ +E Q
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK----FMEDEQQLRRQEGQ 1610
Query: 498 KKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQ 547
++++ + D R + +++R+E+ + P+L ER++Q
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQ 1660
Score = 75.5 bits (184), Expect = 3e-13
Identities = 96/393 (24%), Positives = 171/393 (43%), Gaps = 51/393 (12%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLT 205
Q E KF E+ ++ + + ++E+ R E+ + EEEQ
Sbjct: 1386 QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK------FREEEQQV 1439
Query: 206 REIEAEEN---NDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTS 262
R E E + + + F +L + E ++ RQ
Sbjct: 1440 RRQERERKFLEEEQQLRQERHRKFREE---------------EQLLQEREEQQLHRQERD 1484
Query: 263 WGDIVEEEPARPPGHGIHMHEK-LSSPSRKRTIAESKKKHEEKQMKAQQLREK-LREEKT 320
+ EE+ R E+ L S +R E EE+Q+ QQ + K L+EE+
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE-----EEQQLHRQQRQRKFLQEEQQ 1539
Query: 321 LKLQKLLEREKDVRKWK---EELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAK- 376
L+ Q+ ++ + R K EE L Q R E++L E R+ +L+ + QE+E K
Sbjct: 1540 LRRQERGQQRRQDRDRKFREEEQLRQERE--EQQLSRQERDRKFRLEEQKVRRQEQERKF 1597
Query: 377 VNEIAFINTLEAQNK-RHDVLSKLKEYEQRLNELQEERQRRQE-EKQARDEAVQERKRAL 434
+ + + E Q + R + K +E EQ L E +E++ RQE +++ +E Q R++
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657
Query: 435 EAE------RQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAA 488
E + R+ R EE L++ E++ Q+R K + E R + R+R+ L
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERK----FLQEE 1713
Query: 489 QQEAMEELQKKIQLKHDESIRRHMEQIEQRKEK 521
QQ +EL++K + +E +R+ EQ + R+++
Sbjct: 1714 QQLRRQELERK--FREEEQLRQETEQEQLRRQE 1744
Score = 73.9 bits (180), Expect = 8e-13
Identities = 78/370 (21%), Positives = 167/370 (45%), Gaps = 19/370 (5%)
Query: 147 VNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTR 206
+ EE + +E + + E L ++E+ R E+ + + +++ R
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 207 EIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDI 266
+ ++ +D+ + + + + ++ V G + L D + R+ Q +
Sbjct: 1214 YRDEDQRSDLKWQWEPEKE--NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 267 VEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLRE-KLREEKTLKLQK 325
E++ E+ R+R + EE+Q++ ++ +E K R+ K+ + ++
Sbjct: 1272 GEQQ------------ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ 1319
Query: 326 LLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINT 385
LL E++ ++ ++E R+ EE+LL ++ ++ Q +K +EEE + E
Sbjct: 1320 LLREEREEKRRRQET--DRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Query: 386 LEAQN-KRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEE 444
E Q +R + K + EQ+L + E+Q RQ+ + E Q+ R E +R+ R EE
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ-ERDRKFREEE 1436
Query: 445 LLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKH 504
++R+E+E + ++ Q+ + R RE + +ER Q+ + L+++ QL+
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRR 1496
Query: 505 DESIRRHMEQ 514
E R+ EQ
Sbjct: 1497 QERDRKFREQ 1506
Score = 70.1 bits (170), Expect = 1e-11
Identities = 67/266 (25%), Positives = 128/266 (48%), Gaps = 27/266 (10%)
Query: 283 EKLSSPSRKRTIAES----KKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKE 338
++L R R E +++ +++ + Q+LR + E K L+ ++ L R++ RK+ +
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535
Query: 339 E---LLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQN-KRHD 394
E L Q R + +F+ E QL+ ++ +E++ E LE Q +R +
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLR---QEREEQQLSRQERDRKFRLEEQKVRRQE 1592
Query: 395 VLSKLKEYEQRL------NELQEERQRR-QEEKQARDEAVQERKRALEAERQARVEELLM 447
K E EQ+L +L++ER R+ +E++Q E +++ E +R+ EE +
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQL 1652
Query: 448 KRKEQEARIEQQRQEK--------EKAREDAARERARDREERLAALTAAQQEAMEE-LQK 498
+R+E+E ++ R K ++ E R + RDR+ R +QE + LQ+
Sbjct: 1653 RRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQE 1712
Query: 499 KIQLKHDESIRRHMEQIEQRKEKAAE 524
+ QL+ E R+ E+ + R+E E
Sbjct: 1713 EQQLRRQELERKFREEEQLRQETEQE 1738
Score = 67.4 bits (163), Expect = 7e-11
Identities = 96/460 (20%), Positives = 190/460 (41%), Gaps = 91/460 (19%)
Query: 254 RESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLRE 313
R+ W + D +++E + L KR + E ++++ E++ Q+ +
Sbjct: 1013 RQEWERQYRKKDELQQEE----------EQLLREEREKRRLQERERQYREEEELQQEEEQ 1062
Query: 314 KLREEKTLKLQKLLER----EKDVRKWKEELL----DQRRRMM--------------EEK 351
L EE+ + ++ LER E+++++ +E+LL ++RRR EE+
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQ 1122
Query: 352 LLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQE 411
LL E + + + Q + ++ +EEE E + E + +R L + + +E
Sbjct: 1123 LLREE-REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELER---------QYRE 1172
Query: 412 ERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRK-EQEARIEQQRQEK----EKA 466
E + +QEE+Q E ++ KR E ERQ R EE L ++K +Q R E QR + E
Sbjct: 1173 EEELQQEEEQLLRE--EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE 1230
Query: 467 REDAARE---------------------RARDREERLAALTAAQQEAMEELQKKIQLKHD 505
+E+A R+ R R ++ L L QQE E +++ + D
Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRD 1290
Query: 506 ESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHV 565
EQ+E+ ++K A+ + + E++++ E L
Sbjct: 1291 RHFPEE-EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLL---- 1345
Query: 566 KGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKK 625
+ R+ Q R+ + R+ +EE+ H + + L++ + ++ +++
Sbjct: 1346 QEREEQPLRRQE---RDRKFREEELRHQEQGR-------------KFLEEEQRLRRQERE 1389
Query: 626 AKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKD 665
K +K R +E E + + +L R +D
Sbjct: 1390 RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERD 1429
Score = 63.9 bits (154), Expect = 8e-10
Identities = 53/209 (25%), Positives = 104/209 (49%), Gaps = 18/209 (8%)
Query: 327 LEREKDVR-KWKEELLDQRRRMMEEKLLHAEFKR--EVQLQAIVKKAQEEEAKVNEIAFI 383
L+ EK R KE LL RR+ +++ ++ E Q +K QE+E ++ E
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 384 NTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQAR-----------DEAVQERKR 432
+ + + ++ D + +E ++ E QE +RR EE+Q + DE R+
Sbjct: 155 SEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 433 ALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEA 492
LE R+ R EE +R+E++ R+ Q+ +EKE + + R EE+L +Q
Sbjct: 215 LLELRRKGR-EEKQQQRRERQDRVFQEEEEKEWRKRETV---LRKEEEKLQEEEPQRQRE 270
Query: 493 MEELQKKIQLKHDESIRRHMEQIEQRKEK 521
++E +++++ + +RR ++ EQ++++
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQR 299
Score = 58.2 bits (139), Expect = 5e-08
Identities = 58/271 (21%), Positives = 123/271 (45%), Gaps = 49/271 (18%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKL---QKLLEREKDVRKWKEE 339
EK ++ + + ++ + +Q++ QLR++ ++ L Q+ +RE++ R+W++
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQ- 1288
Query: 340 LLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKL 399
+ R EE+ L E ++E + + +K+QEE+ + E E + +R + K
Sbjct: 1289 ---RDRHFPEEEQLEREEQKEAKRRD--RKSQEEKQLLRE-----EREEKRRRQETDRKF 1338
Query: 400 KEYEQRLNELQE----------------------------ERQRRQEEKQARDEAVQERK 431
+E EQ L E +E E QR + +++ R +E++
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398
Query: 432 -RALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQ 490
R E E+Q R + R+E++ Q+R K + E R + R+R+ +Q
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK-----FLEEEQ 1453
Query: 491 EAMEELQKKIQLKHDESIRRHMEQIEQRKEK 521
+ +E +K + + ++ ++ EQ R+E+
Sbjct: 1454 QLRQERHRKFR-EEEQLLQEREEQQLHRQER 1483
Score = 53.5 bits (127), Expect = 1e-06
Identities = 48/205 (23%), Positives = 98/205 (47%), Gaps = 37/205 (18%)
Query: 254 RESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAES---KKKHEEKQMKAQQ 310
+E R+ + I+EEE RP ++L R R E +++ EE+Q+++Q+
Sbjct: 1737 QEQLRRQERYRKILEEEQLRPERE----EQQLRRQERDRKFREEEQLRQEREEQQLRSQE 1792
Query: 311 LREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKA 370
K REE+ L+ +E++ ++ + + D + R EE+L E ++ ++ + +
Sbjct: 1793 SDRKFREEEQLR------QEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846
Query: 371 QEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQER 430
EE+ E K + EQ L + +E+++R++ E++ R+E + R
Sbjct: 1847 AEEQFATQE------------------KSRREEQELWQEEEQKRRQERERKLREEHI--R 1886
Query: 431 KRALEAERQARVEELLMKRKEQEAR 455
++ E +R +V E+ K QE +
Sbjct: 1887 RQQKEEQRHRQVGEI----KSQEGK 1907
Score = 48.1 bits (113), Expect = 5e-05
Identities = 62/300 (20%), Positives = 127/300 (42%), Gaps = 40/300 (13%)
Query: 410 QEERQRRQE--EKQARDEAVQERK-RALEAERQARVEELLMKRKEQEARIEQQRQEKEKA 466
QEE QRR E ++Q +E Q R+ + E ER+ E +++E+ + ++QR+++E
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELW 174
Query: 467 REDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELS 526
R+ R+ ++REER A Q E + + +E +RR E +E R++ E
Sbjct: 175 RQ---RQEWQEREERRAEEEQLQSCKGHETE---EFPDEEQLRRR-ELLELRRKGREEKQ 227
Query: 527 SGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELS 586
R D ++ E +K+ ++ RK ++ ++E + REL
Sbjct: 228 QQRRERQD---RVFQEEEEKEWRKRETVL------------RKEEEKLQEEEPQRQRELQ 272
Query: 587 DEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMET 646
+EE E E + ERQ+ +++ ++++ R K+ E E
Sbjct: 273 EEE---------------EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 647 KNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWANNKVSALDRTLGEITRILEKENVADQI 706
+ + + + Q ++ + + ++ + +R ++ R E+E Q+
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQL 377
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 92.4 bits (228), Expect = 2e-18
Identities = 93/416 (22%), Positives = 193/416 (46%), Gaps = 44/416 (10%)
Query: 150 EKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIE 209
EK E+ + E+ + I++ E+ K EL ++L E + ++ L R++E
Sbjct: 193 EKLTKERDALSLELYRNTITDE--ELKEKNAELQEKLRLVESEKSEIQLNVKD-LKRKLE 249
Query: 210 AEE----NNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD 265
+ + +E D S+ + + + WN +L + + WRQ +
Sbjct: 250 RAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWN-LLNQQQEEKMWRQEEKIQE 308
Query: 266 IVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQM-----KAQQLREKLREEKT 320
EE+ EK+ K E K + +E +M K ++ EK+RE++
Sbjct: 309 -QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQE- 366
Query: 321 LKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLLHAEFKREVQLQAIVKKAQEEEAKVN 378
+K+ +E+ +R+ E++ +Q M EEK+ E KR+ ++ KK +E++ K+
Sbjct: 367 ---EKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR 423
Query: 379 EIAF--------INTLEA-----QNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDE 425
E I LE + K +V K++E E+++ E +E+ QR++E+ Q ++E
Sbjct: 424 EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEE 483
Query: 426 AVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAAL 485
+++ L+ E + +E M R+E++ ++++ ++++ + E+ R++E RL
Sbjct: 484 KTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRL--- 540
Query: 486 TAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTP 541
Q+E M+E + ++Q + + ++ Q+ E +GR + + P LTP
Sbjct: 541 -WQQEEKMQEQEVRLQ-----ELEERLGKLGQKAELLG--GAGRESGSQRLPTLTP 588
Score = 78.6 bits (192), Expect = 3e-14
Identities = 95/416 (22%), Positives = 182/416 (43%), Gaps = 38/416 (9%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSM--AEVLAKKEEL---ADRLEKANEEAIAS--AI 198
++ E+ E + E +++ D+ + A++L +++L ADRL K + A A
Sbjct: 222 ELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQ 281
Query: 199 AEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMD-WNDVLADYEARESW 257
EE +L + ++ + + + + M + W +E E
Sbjct: 282 VEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKI 341
Query: 258 RQNTS--WGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKL 315
R+ W +EE R I E+ ++ I E +K +E++ + + EK+
Sbjct: 342 REQEDKMWR---QEEKIREQEEKIREQEEKMWRQEEK-IREQDEKIQEQEEEMWRQEEKI 397
Query: 316 REEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLLHAEFK---REVQLQAIVKKA 370
RE++ + +K+ +EK +R+ E++ +Q M EEK+ E +E +L+ + +K
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457
Query: 371 QEEEAKVNEIAF--------INTLEAQNKRHDVL----SKLKEYEQRLNELQEERQRRQE 418
QEEE K+ E I E + R + L K+ E E+++ QEE+ QE
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWR-QEEKMWEQE 516
Query: 419 EKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDR 478
EK E +R+ E++ R+ + K +EQE R+++ + K + A R
Sbjct: 517 EKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGR 576
Query: 479 E---ERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHA 531
E +RL LT Q ++ + + + + R H++Q + +L+SG+ A
Sbjct: 577 ESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQ---QLASGKEA 629
Score = 70.1 bits (170), Expect = 1e-11
Identities = 75/264 (28%), Positives = 127/264 (48%), Gaps = 37/264 (14%)
Query: 302 EEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREV 361
EE + K +L+EKLR L+E EK + + + D +R++ +LL + + +V
Sbjct: 214 EELKEKNAELQEKLR---------LVESEKS--EIQLNVKDLKRKLERAQLLLPQQQLQV 262
Query: 362 QLQAIVKKAQEEEAKV------NEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQR 415
+ + K+ Q AK+ NE+ + + + K K++E E+++ E QE + R
Sbjct: 263 EADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCE-QELKIR 321
Query: 416 RQEEKQARDEAV---QERKRALEAERQARVEELLMKRKEQEARIEQQ-----RQEKEKAR 467
QEEK R E QE K + ++ R EE K +EQE +I +Q RQE++
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQEE---KIREQEEKIREQEEKMWRQEEKIRE 378
Query: 468 EDAARERARD----REERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAA 523
+D + + +EE++ +QE M +KK++ + DE IR E++ +++EK
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMR-EQDEKIREQEEEMWRQEEKIR 437
Query: 524 ELSSGRHANTDYAPKLTPYERKKQ 547
EL D KL E K Q
Sbjct: 438 EL---EEMMQDQEEKLREVEEKMQ 458
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 92.4 bits (228), Expect = 2e-18
Identities = 80/288 (27%), Positives = 148/288 (51%), Gaps = 23/288 (7%)
Query: 279 IHMHEKLSSPSRKRTIAES-KKKHEEKQMKAQQLREKLR---EEKTLKLQKLLEREKDVR 334
+ M K S ++R E+ ++K E +Q++ Q++ E R EE LK ++ L + R
Sbjct: 526 LRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 585
Query: 335 KWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAF-INTLEAQNKRH 393
+ E++ +++++ +E+K + K E +A ++ EE+AK A + +EA+ K+
Sbjct: 586 ERVEQMKEEKKKQIEQKFAQIDEKTE---KAKEERLAEEKAKKKAAAKKMEEVEARRKQE 642
Query: 394 DVLSKLKEYEQRLNEL--QEERQRRQEEKQARDEAVQERKRALEAERQARVEELL----- 446
+ +L+ +Q E QE Q+++EE+Q R E KR E Q R E+
Sbjct: 643 EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER 702
Query: 447 --MKRKEQEARIEQQRQ--EKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQL 502
+R+EQE R EQ+RQ E+E+ RE + R+ +ER AL +++ EL++K +
Sbjct: 703 REQERREQERR-EQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK 761
Query: 503 KHDESI--RRHMEQIEQRKEKAAELSSGRHANTD-YAPKLTPYERKKQ 547
+ + + R+ E+ E++ ++AA S + D +P T Y+ Q
Sbjct: 762 EEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQ 809
Score = 48.9 bits (115), Expect = 3e-05
Identities = 57/275 (20%), Positives = 121/275 (44%), Gaps = 36/275 (13%)
Query: 155 EKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENN 214
E ++ + D + EV K+EE ++ +A E +++Q+ ++ +
Sbjct: 550 EAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEK 609
Query: 215 DINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARP 274
+ + ++ A + + + + EAR + +++E
Sbjct: 610 TEKAKEERLAEEKAKKKAAAKK-----------MEEVEARRKQEEEARRLRWLQQEEEER 658
Query: 275 PGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVR 334
+ +K R R AE+K+ E+++ Q+ RE+ R E+ + Q+ RE++ R
Sbjct: 659 RHQELLQKKKEEEQERLRKAAEAKRLAEQRE---QERREQERREQERREQE--RREQERR 713
Query: 335 KWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHD 394
+ + +L +Q RR +E+L + +RE+Q + + Q+E+ + LE + K
Sbjct: 714 EQERQLAEQERRREQERL---QAERELQEREKALRLQKEQLQ-------RELEEKKK--- 760
Query: 395 VLSKLKEYEQRLNE--LQEERQRRQEEKQARDEAV 427
KE +QRL E LQEE++++ +E +A+
Sbjct: 761 -----KEEQQRLAERQLQEEQEKKAKEAAGASKAL 790
Score = 47.0 bits (110), Expect = 1e-04
Identities = 66/291 (22%), Positives = 124/291 (42%), Gaps = 51/291 (17%)
Query: 397 SKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQ--------ARVEELLMK 448
S +K + +R L+ + + EK+ + RK E R+ R+EE+ +K
Sbjct: 514 SVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK 573
Query: 449 RKEQ-------EARIEQQRQEKEK------AREDAARERARDREERLAALTAAQQEA--- 492
R+E+ R+EQ ++EK+K A+ D E+A +EERLA A ++ A
Sbjct: 574 REERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA--KEERLAEEKAKKKAAAKK 631
Query: 493 MEELQKKIQ----------LKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPY 542
MEE++ + + L+ +E RRH E ++++KE+ E + A +
Sbjct: 632 MEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQE-RLRKAAEAKRLAEQREQ 690
Query: 543 ERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDI 602
ER++Q + R+ Q+ + Q R+L+++E +
Sbjct: 691 ERREQ--------------ERREQERREQERREQERREQERQLAEQERRREQERLQAERE 736
Query: 603 VVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDS 653
+ E K+ +R+ +KK K+ + R+ R + E + K + S
Sbjct: 737 LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGAS 787
Score = 38.9 bits (89), Expect = 0.029
Identities = 72/377 (19%), Positives = 151/377 (40%), Gaps = 48/377 (12%)
Query: 400 KEYEQRLNELQEERQRRQEEKQ-ARDEAVQERKRALEAERQARV-------EELLMK--- 448
+ Y+Q ++EL EE+ EE Q R + A + R R ++LM
Sbjct: 451 RSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTS 510
Query: 449 ----------RKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQK 498
++ R++ + EK R+ R ++ E+L +E +
Sbjct: 511 APRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKV--EEDKRRRLE 568
Query: 499 KIQLKHDESIRRHM---EQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLI 555
+++LK +E +R+ + E++EQ KE+ + + A D + ER +
Sbjct: 569 EVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 628
Query: 556 SSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLS-LKKYIIDIVVESTAPAEALK 614
+ ++ V+ R+ Q+ E ++ + +EE H L+K + AEA +
Sbjct: 629 AKKM---EEVEARRKQE--EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKR 683
Query: 615 DGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQD 674
E+R++ +++ ++ + + + + E + ++ + + +RL + ++Q+
Sbjct: 684 LAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER----ELQE 739
Query: 675 SGSWANNKVSALDRTLGEITRILEKENVA--------DQIAFQAAGGLTALEHILQAVVP 726
+ L R L E + E++ +A ++ A +AAG AL + P
Sbjct: 740 REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSP 799
Query: 727 ATNVNTVL----RIPPK 739
A + R PPK
Sbjct: 800 ACTSYQMTPQGHRAPPK 816
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 90.5 bits (223), Expect = 8e-18
Identities = 93/416 (22%), Positives = 192/416 (46%), Gaps = 44/416 (10%)
Query: 150 EKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIE 209
EK E+ E+ + I++ E+ K EL ++L E + ++ L R++E
Sbjct: 193 EKLTKERDAPSLELYRNTITDE--ELKEKNAELQEKLRLVESEKSEIQLNVKD-LKRKLE 249
Query: 210 AEE----NNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD 265
+ + +E D S+ + + + WN +L + + WRQ +
Sbjct: 250 RAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWN-LLNQQQEEKMWRQEEKIQE 308
Query: 266 IVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQM-----KAQQLREKLREEKT 320
EE+ EK+ K E K + +E +M K ++ EK+RE++
Sbjct: 309 -QEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQE- 366
Query: 321 LKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLLHAEFKREVQLQAIVKKAQEEEAKVN 378
+K+ +E+ +R+ E++ +Q M EEK+ E KR+ ++ KK +E++ K+
Sbjct: 367 ---EKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR 423
Query: 379 EIAF--------INTLEA-----QNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDE 425
E I LE + K +V K++E E+++ E +E+ QR++E+ Q ++E
Sbjct: 424 EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEE 483
Query: 426 AVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAAL 485
+++ L+ E + +E M R+E++ ++++ ++++ + E+ R++E RL
Sbjct: 484 KTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRL--- 540
Query: 486 TAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTP 541
Q+E M+E + ++Q + + ++ Q+ E +GR + + P LTP
Sbjct: 541 -WQQEEKMQEQEVRLQ-----ELEERLGKLGQKAELLG--GAGRESGSQRLPTLTP 588
Score = 78.6 bits (192), Expect = 3e-14
Identities = 95/416 (22%), Positives = 182/416 (43%), Gaps = 38/416 (9%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSM--AEVLAKKEEL---ADRLEKANEEAIAS--AI 198
++ E+ E + E +++ D+ + A++L +++L ADRL K + A A
Sbjct: 222 ELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQ 281
Query: 199 AEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMD-WNDVLADYEARESW 257
EE +L + ++ + + + + M + W +E E
Sbjct: 282 VEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKI 341
Query: 258 RQNTS--WGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKL 315
R+ W +EE R I E+ ++ I E +K +E++ + + EK+
Sbjct: 342 REQEDKMWR---QEEKIREQEEKIREQEEKMWRQEEK-IREQDEKIQEQEEEMWRQEEKI 397
Query: 316 REEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLLHAEFK---REVQLQAIVKKA 370
RE++ + +K+ +EK +R+ E++ +Q M EEK+ E +E +L+ + +K
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457
Query: 371 QEEEAKVNEIAF--------INTLEAQNKRHDVL----SKLKEYEQRLNELQEERQRRQE 418
QEEE K+ E I E + R + L K+ E E+++ QEE+ QE
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWR-QEEKMWEQE 516
Query: 419 EKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDR 478
EK E +R+ E++ R+ + K +EQE R+++ + K + A R
Sbjct: 517 EKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGR 576
Query: 479 E---ERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHA 531
E +RL LT Q ++ + + + + R H++Q + +L+SG+ A
Sbjct: 577 ESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYVAAYQ---QLASGKEA 629
Score = 70.1 bits (170), Expect = 1e-11
Identities = 75/264 (28%), Positives = 127/264 (48%), Gaps = 37/264 (14%)
Query: 302 EEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREV 361
EE + K +L+EKLR L+E EK + + + D +R++ +LL + + +V
Sbjct: 214 EELKEKNAELQEKLR---------LVESEKS--EIQLNVKDLKRKLERAQLLLPQQQLQV 262
Query: 362 QLQAIVKKAQEEEAKV------NEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQR 415
+ + K+ Q AK+ NE+ + + + K K++E E+++ E QE + R
Sbjct: 263 EADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCE-QELKIR 321
Query: 416 RQEEKQARDEAV---QERKRALEAERQARVEELLMKRKEQEARIEQQ-----RQEKEKAR 467
QEEK R E QE K + ++ R EE K +EQE +I +Q RQE++
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQEE---KIREQEEKIREQEEKMWRQEEKIRE 378
Query: 468 EDAARERARD----REERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAA 523
+D + + +EE++ +QE M +KK++ + DE IR E++ +++EK
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMR-EQDEKIREQEEEMWRQEEKIR 437
Query: 524 ELSSGRHANTDYAPKLTPYERKKQ 547
EL D KL E K Q
Sbjct: 438 EL---EEMMQDQEEKLREVEEKMQ 458
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 90.5 bits (223), Expect = 8e-18
Identities = 75/275 (27%), Positives = 142/275 (51%), Gaps = 22/275 (8%)
Query: 291 KRTIAESKKKHEEKQMKAQQLREKLR---EEKTLKLQKLLEREKDVRKWKEELLDQRRRM 347
++ + ++K E +Q++ Q++ E R EE LK ++ L + R+ E++ +++++
Sbjct: 535 RQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQ 594
Query: 348 MEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAF-INTLEAQNKRHDVLSKLKEYEQRL 406
+E+K + K E +A ++ EE+AK A + +EA+ K+ + +L+ +Q
Sbjct: 595 IEQKFAQIDEKTE---KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 651
Query: 407 NEL--QEERQRRQEEKQARDEAVQERKRALEAERQARVEELL-------MKRKEQEARIE 457
E QE Q+++EE+Q R E KR E Q R E+ +R+EQE R E
Sbjct: 652 EERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERR-E 710
Query: 458 QQRQ--EKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESI--RRHME 513
Q+RQ E+E+ RE + R+ +ER AL +++ EL++K + + + + R+ E
Sbjct: 711 QERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQE 770
Query: 514 QIEQRKEKAAELSSGRHANTD-YAPKLTPYERKKQ 547
+ E++ ++AA S + D +P T Y+ Q
Sbjct: 771 EQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQ 805
Score = 75.5 bits (184), Expect = 3e-13
Identities = 57/229 (24%), Positives = 116/229 (50%), Gaps = 26/229 (11%)
Query: 290 RKRTIAESKKKHEEKQMKAQQLREK---LREEKTLKL-QKLLEREKDVRKWKEELL---- 341
++R + E K K EE+ K Q RE+ ++EEK ++ QK + ++ K KEE L
Sbjct: 559 KRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK 618
Query: 342 -------------DQRRRMMEE----KLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFIN 384
+ RR+ EE + L E + + + KK +EE+ ++ + A
Sbjct: 619 AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK 678
Query: 385 TLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEE 444
L Q ++ + +E E+R E +E+ +R QE + A E +E++R L+AER+ + E
Sbjct: 679 RLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQER-LQAERELQERE 737
Query: 445 LLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAM 493
++ ++++ + E + ++K++ ++ A + ++ +E+ A A +A+
Sbjct: 738 KALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 786
Score = 70.1 bits (170), Expect = 1e-11
Identities = 74/262 (28%), Positives = 125/262 (47%), Gaps = 17/262 (6%)
Query: 271 PARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLERE 330
P R H + ++ L +P+ + S K K+ ++ K +E + L+ + E
Sbjct: 491 PLRTFLHTVQRNQMLMTPT---SAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEA 547
Query: 331 KDVRKWKEELLDQRRRMMEEKLLHAEFKREV-QLQAIVKKAQEEEAKVNEIAFINTLEAQ 389
+ +R+ K E D+RRR+ E KL E R+V Q + V++ +EE+ K E F E
Sbjct: 548 EQLRRQKVEE-DKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 606
Query: 390 NKRHD--VLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARV-EELL 446
K + + + + + +++E RR++E++AR R R L+ E + R +ELL
Sbjct: 607 EKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR------RLRWLQQEEEERRHQELL 660
Query: 447 MKRKEQEA-RIEQQRQEKEKA--REDAARERARDREERLAALTAAQQEAMEELQKKIQLK 503
K+KE+E R+ + + K A RE RE+ R +ER Q+ +E Q Q +
Sbjct: 661 QKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQER 720
Query: 504 HDESIRRHMEQIEQRKEKAAEL 525
E R E+ Q +EKA L
Sbjct: 721 RREQERLQAERELQEREKALRL 742
Score = 69.3 bits (168), Expect = 2e-11
Identities = 127/587 (21%), Positives = 239/587 (40%), Gaps = 77/587 (13%)
Query: 67 KGQFVGDGTSNT------IESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNY-V 119
KGQ VG G S + + P+DS D P E+ + + +GS D+ V
Sbjct: 244 KGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSV 303
Query: 120 RTSEISAVHIDTECVS--VMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLA 177
R S I+ + ++ L A + + A+K E I +S E L
Sbjct: 304 RHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLL 363
Query: 178 KKE---ELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASM---- 230
E ++ ++ EEA A AE E ENN N ND++ + S
Sbjct: 364 NVEVPQKVGSEQKEPPEEAEPVAAAEPE-------VPENNGNNSWPHNDTEIANSTPNPK 416
Query: 231 ---GSGSVSFCGMSMDWNDVL-ADYEARESWRQNTSWGDIV---------EEEPARPPGH 277
S G D E +S R+ S+ V E+E +PP
Sbjct: 417 PAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPP-- 474
Query: 278 GIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWK 337
+ SSP + + + Q L +++ ++ ++R +R
Sbjct: 475 ---RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSV-MKSFIKRNTPLRMDP 530
Query: 338 EELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLS 397
+E QR + K + +R+ K +E++ + E E + KR + L
Sbjct: 531 KEKERQRLENLRRKEEAEQLRRQ--------KVEEDKRRRLE-------EVKLKREERLR 575
Query: 398 KLKEYEQRLNELQEERQRRQEEKQAR-DEAVQERKRALEAERQARVEELLMKRKEQEARI 456
K+ + +R+ +++EE++++ E+K A+ DE ++ K AE +A+ + K +E EAR
Sbjct: 576 KVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARR 635
Query: 457 EQ----------QRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDE 506
+Q Q++E+E+ ++ +++ + +ERL A++ A + Q++ + + E
Sbjct: 636 KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE 695
Query: 507 SIRRHMEQIEQ-RKEKAAELS--SGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFS 563
RR E+ EQ R+E+ +L+ R + ER+K L + E+
Sbjct: 696 QERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQREL---E 752
Query: 564 HVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPA 610
K ++ QQ + E Q +E +++ + + +++ V+ +PA
Sbjct: 753 EKKKKEEQQRLAER---QLQEEQEKKAKEAAGASKALNVTVDVQSPA 796
Score = 63.9 bits (154), Expect = 8e-10
Identities = 67/275 (24%), Positives = 129/275 (46%), Gaps = 44/275 (16%)
Query: 405 RLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQ-------EARIE 457
R++ ++ERQR E + ++EA Q R++ +E +++ R+EE+ +KR+E+ R+E
Sbjct: 527 RMDPKEKERQRL-ENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVE 585
Query: 458 QQRQEKEK------AREDAARERARDREERLAALTAAQQEA---MEELQKKIQ------- 501
Q ++EK+K A+ D E+A+ EERLA A ++ A MEE++ + +
Sbjct: 586 QMKEEKKKQIEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 643
Query: 502 ---LKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSE 558
L+ +E RRH E ++++KE+ E + A + ER++Q
Sbjct: 644 LRWLQQEEEERRHQELLQKKKEEEQE-RLRKAAEAKRLAEQREQERREQ----------- 691
Query: 559 VYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEE 618
+ R+ Q+ + Q R+L+++E + + E K+ +
Sbjct: 692 ---ERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQ 748
Query: 619 RQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDS 653
R+ +KK K+ + R+ R + E + K + S
Sbjct: 749 RELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGAS 783
Score = 42.4 bits (98), Expect = 0.003
Identities = 71/371 (19%), Positives = 151/371 (40%), Gaps = 40/371 (10%)
Query: 400 KEYEQRLNELQEERQRRQEEKQ-ARDEAVQERKRALEAERQARV-------EELLMKRKE 451
+ Y+Q ++EL EE+ EE Q R + A + R R ++LM
Sbjct: 451 RSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTS 510
Query: 452 QEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQ-------KKIQLKH 504
+ + ++ +E+ R R E L A+Q ++++ ++++LK
Sbjct: 511 APRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKR 570
Query: 505 DESIRRHM---EQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYL 561
+E +R+ + E++EQ KE+ + + A D + ER + + ++
Sbjct: 571 EERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKM-- 628
Query: 562 FSHVKGRKHQQAVRENTSIQGRELSDEEVEHLS-LKKYIIDIVVESTAPAEALKDGEERQ 620
V+ R+ Q+ E ++ + +EE H L+K + AEA + E+R+
Sbjct: 629 -EEVEARRKQE--EEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 685
Query: 621 KNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWAN 680
+ +++ ++ + + + + E + ++ + + +RL + ++Q+
Sbjct: 686 QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAER----ELQEREKALR 741
Query: 681 NKVSALDRTLGEITRILEKENVA--------DQIAFQAAGGLTALEHILQAVVPATNVNT 732
+ L R L E + E++ +A ++ A +AAG AL + PA
Sbjct: 742 LQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQ 801
Query: 733 VL----RIPPK 739
+ R PPK
Sbjct: 802 MTPQGHRAPPK 812
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 88.6 bits (218), Expect = 3e-17
Identities = 101/396 (25%), Positives = 187/396 (47%), Gaps = 68/396 (17%)
Query: 138 LQAGTPPLQVNEEKF--PAEKARIENEM--DPSDISNSMAEVLAKKEELADRLEKA---N 190
+Q ++ EEK EK R + EM + + E++ +KEE R E+
Sbjct: 377 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 436
Query: 191 EEAIASA---IAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDV 247
EE I + E+E++ + E + + E + + A M W
Sbjct: 437 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM-------------WRQE 483
Query: 248 LADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMK 307
E E R+ +EE IH EK I E +K+ E+++M
Sbjct: 484 EKIREQEEKIRE--------QEEKMWRQEEKIHEQEK---------IREEEKRQEQEEMW 526
Query: 308 AQQLREKLREEKTL--KLQKLLEREKDVRKWKEELLDQRRRM--MEEKLLHAE---FKRE 360
Q+ EK+RE++ + + +K+ E+E+ +RK +E++ Q +M EEK+ E +++E
Sbjct: 527 RQE--EKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQE 584
Query: 361 VQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEK 420
+++ +K +E+E K+ E + T E + K + K+ E E+++ E QEE+ RRQEEK
Sbjct: 585 EKIREQEEKIREQEEKIREQEEM-TQEQEEKMGEQEEKMCEQEEKMQE-QEEKMRRQEEK 642
Query: 421 QARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREE 480
E K+ E E + R +E +M+ +E E+ +++EK E E+ +++EE
Sbjct: 643 IREQE-----KKIREQEEKIREQEEMMQEQE-----EKMWEQEEKMCEQ--EEKMQEQEE 690
Query: 481 RLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
++ Q+E M E + +++ + +E ++ H E +E
Sbjct: 691 KM----RRQEEKMWEQEVRLR-QQEEKMQEHQEHLE 721
Score = 84.7 bits (208), Expect = 5e-16
Identities = 83/390 (21%), Positives = 182/390 (46%), Gaps = 50/390 (12%)
Query: 157 ARIENEMDPSDISNSMAEVLAKK-----EELADRLEKANEEAIASAIAEEEQLTREIEAE 211
A+++ +++ +++ N + + +K E++ + EK E+ I E+E+ RE E +
Sbjct: 340 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE--EKIREQEEKIREQEEK 397
Query: 212 ENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEP 271
+ + + +++ + E + ++ W +EE
Sbjct: 398 MRRQEEMMWEKEEKMRRQ---------------EEMMWEKEEKMRRQEEMMWE---KEEK 439
Query: 272 ARPPGHGIHMHEKLSSPSRKRTIAES---KKKHEEKQMKAQQLREKLREEKTLKLQKLLE 328
R +H EK+ KR E ++K +E++ K + EK+RE++ +K+ E
Sbjct: 440 IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE----EKIRE 495
Query: 329 REKDVRKWKEELLDQRRRMMEEKLLHAE--------FKREVQLQAIVKKAQEEEAKVNEI 380
+E+ + + +E++ +Q + EEK E + + ++ +K E+E K+ +
Sbjct: 496 QEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ 555
Query: 381 AFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQA 440
+ K HD K++E E+++ QEE+ R QEEK E + + E++
Sbjct: 556 EE-KMWRQEEKMHDQEEKIREQEEKVWR-QEEKIREQEEKIREQEEKIREQEEMTQEQEE 613
Query: 441 RVEELLMKRKEQEARIEQQ----RQEKEKAREDAARERARDREERLAALTAAQQEAMEEL 496
++ E K EQE ++++Q R+++EK RE ++ R++EE++ QE E++
Sbjct: 614 KMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQ--EKKIREQEEKIREQEEMMQEQEEKM 671
Query: 497 --QKKIQLKHDESIRRHMEQIEQRKEKAAE 524
Q++ + +E ++ E++ +++EK E
Sbjct: 672 WEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 701
Score = 82.8 bits (203), Expect = 2e-15
Identities = 81/389 (20%), Positives = 189/389 (48%), Gaps = 38/389 (9%)
Query: 280 HMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEE 339
H+ ++L S S K + Q++ +L +L +++ +K+ +E+ +++W+E+
Sbjct: 330 HLGKELQSVSAKL----------QAQVEENELWNRLNQQQE---EKMWRQEEKIQEWEEK 376
Query: 340 LLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVL--- 396
+ +Q ++ E++ E + +++ Q + +EE+ + E E ++ +++
Sbjct: 377 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 436
Query: 397 -SKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAE-RQARVEELLMKRKEQEA 454
K++E E++++E +E+ R QEEK+ +E ++E+++ E E + R EE K +EQE
Sbjct: 437 EEKIRELEEKMHE--QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE---KIREQEE 491
Query: 455 RIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQ 514
+I +Q +EK +E+ E+ + REE +QE E +++ +++ E I R E+
Sbjct: 492 KIREQ-EEKMWRQEEKIHEQEKIREEE------KRQEQEEMWRQEEKIREQEEIWRQKEK 544
Query: 515 IEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAV 574
I +++EK + + K+ E K + V E K R+ ++ +
Sbjct: 545 IHEQEEKIRKQEEKMWRQEE---KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKI 601
Query: 575 REN---TSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKA 631
RE T Q ++ ++E + ++ + + + E ++ E+ +K +++ +KI+
Sbjct: 602 REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIR--EQEKKIREQEEKIRE 659
Query: 632 RMNFRAKEYESLMETKNSGSDSPYKAKLQ 660
+ ++ E + E + + K + Q
Sbjct: 660 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQ 688
Score = 80.5 bits (197), Expect = 9e-15
Identities = 65/270 (24%), Positives = 145/270 (53%), Gaps = 18/270 (6%)
Query: 266 IVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQK 325
I E+E R I EK K E K + +E++++ Q+ + +EEK + +K
Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEK 512
Query: 326 LLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQE-----EEAKVNEI 380
+ E EK R+ +EE+ Q ++ E++ + + ++ + + ++K +E EE ++
Sbjct: 513 IREEEK--RQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQE 570
Query: 381 AFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRAL-EAERQ 439
I E + R + K++E E+++ E +E+ + ++E Q ++E + E++ + E E +
Sbjct: 571 EKIREQEEKVWRQE--EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK 628
Query: 440 ARVEELLMKRKEQEARIEQQ--RQEKEKAREDAARERARDREERL---AALTAAQQEAME 494
+ +E M+R+E++ R +++ R+++EK RE E +++EE++ Q+E M+
Sbjct: 629 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQ--EEMMQEQEEKMWEQEEKMCEQEEKMQ 686
Query: 495 ELQKKIQLKHDESIRRHMEQIEQRKEKAAE 524
E ++K++ + +E + ++ Q++EK E
Sbjct: 687 EQEEKMR-RQEEKMWEQEVRLRQQEEKMQE 715
Score = 63.9 bits (154), Expect = 8e-10
Identities = 70/298 (23%), Positives = 133/298 (44%), Gaps = 48/298 (16%)
Query: 149 EEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREI 208
EEK ++ R E E A++ ++E++ ++ EK E+ EE+ +E
Sbjct: 463 EEKIREQEKRQEQE----------AKMWRQEEKIREQEEKIREQ-------EEKMWRQEE 505
Query: 209 EAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVE 268
+ E I E W E E WRQ + +
Sbjct: 506 KIHEQEKIREEEKRQEQEEM---------------WRQEEKIREQEEIWRQKEKIHE--Q 548
Query: 269 EEPARPPGHGI-HMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLL 327
EE R + EK+ K E K +E++++ Q+ + + +EEK + +++
Sbjct: 549 EEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMT 608
Query: 328 -EREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
E+E+ + + +E++ +Q +M E++ ++E +++ KK +E+E K+ E +
Sbjct: 609 QEQEEKMGEQEEKMCEQEEKMQEQE--EKMRRQEEKIREQEKKIREQEEKIREQEEM-MQ 665
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEK--------QARDEAVQERKRALEA 436
E + K + K+ E E+++ E QEE+ RRQEEK + ++E +QE + LEA
Sbjct: 666 EQEEKMWEQEEKMCEQEEKMQE-QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 55.1 bits (131), Expect = 4e-07
Identities = 89/413 (21%), Positives = 175/413 (42%), Gaps = 76/413 (18%)
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQK------LLEREKDVRKWKEELLDQRRRMME 349
E K H+ ++ ++L ++ + L QK L + V++ + E D R+ +
Sbjct: 171 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 230
Query: 350 EKLLHAEFKREVQLQAIVKK---------AQEEEAKVNEIAFINTL---EAQNKRHDVLS 397
E ++ + A KK +E +A E+ + NT+ E + K +
Sbjct: 231 SWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLEL-YRNTITDEELKEKNAKLQE 289
Query: 398 KLKEYEQRLNELQ---EERQRR---------QEEKQARDEAVQERKRALEAERQARVEE- 444
KL+ E +E+Q +E +R+ Q++ QA + + + +++ A+ QA+VEE
Sbjct: 290 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 349
Query: 445 -----LLMKRKEQEARIEQQRQE--------KEKAREDAARERARDREERLAALTAAQQE 491
L +++E+ R E++ QE +EK RE E+ R++EE++ E
Sbjct: 350 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ--EEKIREQEEKMRRQEEMMWE 407
Query: 492 AMEEL--QKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCS 549
E++ Q+++ + +E +RR E + +++EK EL H K+ E K+Q
Sbjct: 408 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ----EKIREQEEKRQ-- 461
Query: 550 LCNVLISSEVYLFSHVKGRKHQQAV--RENTSIQGRELSDEEVEHLSLKKYIIDIVVEST 607
E + R+ Q+A R+ I+ +E E E ++ E
Sbjct: 462 --------EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ------EEKI 507
Query: 608 APAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ 660
E +++ E+RQ+ ++ R + +E E + K + K + Q
Sbjct: 508 HEQEKIREEEKRQEQEE-----MWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ 555
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 87.8 bits (216), Expect = 5e-17
Identities = 69/251 (27%), Positives = 134/251 (53%), Gaps = 19/251 (7%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLD 342
EK+ K E ++ EEK+ + +++RE+ E++ + K+ +E+ +R+ +E++ +
Sbjct: 377 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQ--EKRQEQEAKMWRQEEKIREQEEKIRE 434
Query: 343 QRRRM--MEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFI----NTLEAQNKRHDVL 396
Q ++M EEK+ E RE + + ++ +E K+ E I + Q K
Sbjct: 435 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494
Query: 397 SKLKEYEQRLNELQEERQRRQEEKQARDE---AVQERKRALEAERQARVEELLMKRKEQE 453
K+ E+++++ QEE+ R QEEK R E QE K + E+ EE++ +++E+
Sbjct: 495 EKVWRQEEKMHD-QEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKM 553
Query: 454 ARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHME 513
E++ QE+EK R E+ R++EE++ Q+E + E ++KI + +E IR E
Sbjct: 554 GEQEEKMQEQEKMRRQ--EEKIREQEEKI----REQKEKIREQEEKI-WEQEEKIREQEE 606
Query: 514 QIEQRKEKAAE 524
+++++EK E
Sbjct: 607 MMQEQEEKMWE 617
Score = 87.4 bits (215), Expect = 7e-17
Identities = 93/406 (22%), Positives = 194/406 (47%), Gaps = 43/406 (10%)
Query: 150 EKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIE 209
E+ E+ + E+ + I++ E+ K +L ++L+ E + +E L R++E
Sbjct: 196 EELTKERDALSLELYRNTITDE--ELKEKNAKLQEKLQLVESEKSEIQLNVKE-LKRKLE 252
Query: 210 AEE----NNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTS--- 262
+ + E D+ S+ + + + WN L + + WRQ
Sbjct: 253 RAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR-LNQQQEEKMWRQEEKIQE 311
Query: 263 WGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLK 322
W + ++E+ + EK+ K E +E++M+ Q+ +EEK +
Sbjct: 312 WEEKIQEQEEKIR----EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 323 LQKLL-EREKDVRKWKEELLDQRR-------RMMEEKLLHAEFKRE--VQLQAIVKKAQE 372
L++++ E+E+ +R+ +E++ +Q + R EEK+ E ++E ++ +K +E
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 427
Query: 373 EEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNE----LQEERQRRQEEKQARDEAVQ 428
+E K+ E + Q ++ K++E E+R + QEE+ R QEE + E +
Sbjct: 428 QEEKIREQE--KKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMH 485
Query: 429 ERKRALEAERQARVEELLMKRKEQEARIEQQR--QEKEKAREDAARERARDREERL---A 483
E+++ + E + +E M +E++ R ++++ +++EK RE E+ R++EE++
Sbjct: 486 EQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQ--EEKIREQEEKIREQE 543
Query: 484 ALTAAQQEAMEELQKKIQ-----LKHDESIRRHMEQIEQRKEKAAE 524
+ Q+E M E ++K+Q + +E IR E+I ++KEK E
Sbjct: 544 EMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIRE 589
Score = 87.0 bits (214), Expect = 9e-17
Identities = 75/280 (26%), Positives = 146/280 (52%), Gaps = 32/280 (11%)
Query: 268 EEEPARPPGHGIHMHEKLSSPSRKRTIAES---KKKHEEKQMKAQQLREKLREEKTLKLQ 324
+EE R +H EK+ KR E ++K +E++ K + EK+RE++ +
Sbjct: 375 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE----E 430
Query: 325 KLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEE----EAKVNEI 380
K+ E+EK + + +E++ +Q + EEK E E+ Q + QEE + K++E
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQE---EMWRQEEKIREQEEIWRQKEKMHEQ 487
Query: 381 AFINTLEA-----QNKRHDVLSKLKEYEQRLNEL------QEERQRRQEEK-QARDEAVQ 428
I E + K HD K++E E+++ QEE+ R QEEK + ++E +Q
Sbjct: 488 EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQ 547
Query: 429 ERKRALEAERQARVEELLMKRKEQEARIEQQ--RQEKEKAREDAARERARDREERLAALT 486
E++ + + + E+ M+R+E++ R +++ R++KEK RE E+ ++EE++
Sbjct: 548 EQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQ--EEKIWEQEEKIREQE 605
Query: 487 AAQQEAMEEL--QKKIQLKHDESIRRHMEQIEQRKEKAAE 524
QE E++ Q++ + +E ++ E++ +++EK E
Sbjct: 606 EMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 645
Score = 83.6 bits (205), Expect = 1e-15
Identities = 96/422 (22%), Positives = 183/422 (43%), Gaps = 48/422 (11%)
Query: 281 MHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKD-------- 332
+ EK + K + ES+K E Q+ ++L+ KL K L Q+ L+ E D
Sbjct: 219 LKEKNAKLQEKLQLVESEKS--EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 276
Query: 333 ------VRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
+ + EL ++ + EEK+ +++E ++Q +K QE+E K+ E
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQEEKM----WRQEEKIQEWEEKIQEQEEKIRE------- 325
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELL 446
+ K + K++ E+ + E +EE+ RRQEE E R + E++ ++ EL
Sbjct: 326 -QEEKIREQEEKMRRQEEMMWE-KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE 383
Query: 447 MKRKEQEARIEQQ--RQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKI---- 500
K EQE EQ+ RQE+EK RE R+ + R Q+E + E +KK+
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQE 443
Query: 501 QLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVY 560
+ H++ R E+ ++++E + R + K +E++K + E
Sbjct: 444 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK------IRKQEEKV 497
Query: 561 LFSHVKGRKHQQAVRENTSIQGRE---LSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
K ++ +RE R+ + ++E + ++ I + E + K GE
Sbjct: 498 WRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIRE--QEEMMQEQEEKMGE 555
Query: 618 ERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKA-KLQRLAKDLLKQVQVQDSG 676
+ +K +++ K + R +E E + E K + K + + ++ + +Q Q+
Sbjct: 556 QEEKMQEQEKMRRQEEKIREQE-EKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEK 614
Query: 677 SW 678
W
Sbjct: 615 MW 616
Score = 80.5 bits (197), Expect = 9e-15
Identities = 92/403 (22%), Positives = 185/403 (45%), Gaps = 77/403 (19%)
Query: 138 LQAGTPPLQVNEEKF--PAEKARIENEM--DPSDISNSMAEVLAKKEELADRLEKANEEA 193
+Q ++ EEK EK R + EM + + E++ +KEE RLE+
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEM---- 371
Query: 194 IASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEA 253
+ E+E+ RE+E + + I + + + + E
Sbjct: 372 ----MWEKEEKIRELEEKMHEQEKIREQEEK-----------------RQEEEKIREQEK 410
Query: 254 RES-----WRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKA 308
R+ WRQ EE R I EK ++ + K + EEK+
Sbjct: 411 RQEQEAKMWRQ---------EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR--- 458
Query: 309 QQLREKLREEKTLKLQKLLEREKD-------VRKWKEELLDQRRRM--MEEKLLHAE--- 356
Q+ E R+E+ ++ Q+ + R+K+ +RK +E++ Q +M EEK+ E
Sbjct: 459 QEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKM 518
Query: 357 FKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRR 416
+++E +++ +K +E+E K+ E + + K+ E E+++ E +E+ RR
Sbjct: 519 WRQEEKIREQEEKIREQEEKIR--------EQEEMMQEQEEKMGEQEEKMQE--QEKMRR 568
Query: 417 QEEK-QARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAA--RE 473
QEEK + ++E ++E+K + E++ ++ E K +EQE +++Q ++ + E E
Sbjct: 569 QEEKIREQEEKIREQKEKIR-EQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE 627
Query: 474 RARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+ +++EE++ Q+E M E + +++ + +E ++ H E +E
Sbjct: 628 KMQEQEEKM----RRQEEKMWEQEVRLR-QQEEKMQEHQEHLE 665
Score = 61.6 bits (148), Expect = 4e-09
Identities = 50/189 (26%), Positives = 92/189 (48%), Gaps = 29/189 (15%)
Query: 257 WRQNTSWGDIVEEEPARPPGHGI-HMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKL 315
WRQ D +EE R + EK+ K E K + +E+ M+ Q+ +
Sbjct: 498 WRQEEKMHD--QEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGE 555
Query: 316 REEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEA 375
+EEK + +K+ +E+ +R+ +E++ +Q+ ++ E++ +K E+E
Sbjct: 556 QEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQE----------------EKIWEQEE 599
Query: 376 KVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEK--------QARDEAV 427
K+ E + E + K + K+ E E+++ E QEE+ RRQEEK + ++E +
Sbjct: 600 KIREQEEM-MQEQEEKMWEQEEKMCEQEEKMQE-QEEKMRRQEEKMWEQEVRLRQQEEKM 657
Query: 428 QERKRALEA 436
QE + LEA
Sbjct: 658 QEHQEHLEA 666
Score = 53.5 bits (127), Expect = 1e-06
Identities = 69/298 (23%), Positives = 135/298 (45%), Gaps = 53/298 (17%)
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQK------LLEREKDVRKWKEELLDQRRRMME 349
E K H+ ++ ++L ++ + L QK L + V++ + E D R+ +
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLHD 169
Query: 350 EKLLHAEFKREVQLQAIVKK---------AQEEEAKVNEIAFINTL---EAQNKRHDVLS 397
E ++ + A KK +E +A E+ + NT+ E + K +
Sbjct: 170 SWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLEL-YRNTITDEELKEKNAKLQE 228
Query: 398 KLKEYEQRLNELQ---EERQRR---------QEEKQARDEAVQERKRALEAERQARVEE- 444
KL+ E +E+Q +E +R+ Q++ QA + + + +++ A+ QA+VEE
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEEN 288
Query: 445 -----LLMKRKEQEARIEQQRQE--------KEKAREDAARERARDREERLAALTAAQQE 491
L +++E+ R E++ QE +EK RE E+ R++EE++ E
Sbjct: 289 ELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ--EEKIREQEEKMRRQEEMMWE 346
Query: 492 AMEEL--QKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQ 547
E++ Q+++ + +E +RR E + +++EK EL H K+ E K+Q
Sbjct: 347 KEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ----EKIREQEEKRQ 400
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 87.8 bits (216), Expect = 5e-17
Identities = 96/467 (20%), Positives = 214/467 (45%), Gaps = 68/467 (14%)
Query: 255 ESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREK 314
E WRQ EEE EK+ + E K + +E++M Q+ R +
Sbjct: 273 EMWRQ--------EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLR 324
Query: 315 LREEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLLHAE---FKREVQLQAIVKK 369
+E++ + +K L +K++R+ +E++ +Q +M EEK+ E +++E +L K+
Sbjct: 325 EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 384
Query: 370 AQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNE----------LQEERQRRQEE 419
+E+E K+ + + + + +L+E E+R+ E ++EE++ +++E
Sbjct: 385 MREQEQKMR--------DQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE 436
Query: 420 KQARD--EAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEK-EKAREDAARERAR 476
K+ RD E +QE +R E E++ R EE M +EQE ++++Q + E+ ++ ++R
Sbjct: 437 KKTRDQEEKMQEEERIREREKKMREEEETM--REQEEKMQKQEENMWEQEEKEWQQQRLP 494
Query: 477 DREERLAALTAAQQEAMEELQKKI------------------QLKHDESIRRHMEQIEQR 518
+++E+L +QE M+E ++KI ++ E +R +Q+ ++
Sbjct: 495 EQKEKL-----WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549
Query: 519 KEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENT 578
+EK + + K T + KK + E K R+ ++ +RE
Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE-- 607
Query: 579 SIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAK 638
Q ++ ++E + ++ + + + E + + EE+ +++ + R+ +
Sbjct: 608 --QEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL---PE 662
Query: 639 EYESLMETKNSGSDSPYKAKLQRL--AKDLLKQVQVQDSGSWANNKV 683
+ E L E + + + +++ + + K+ Q Q+ +W K+
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKM 709
Score = 87.0 bits (214), Expect = 9e-17
Identities = 98/466 (21%), Positives = 204/466 (43%), Gaps = 64/466 (13%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWK--EEL 340
E++ K E K + +E++M Q+ R +EK ++ Q+ R+++ R W+ E L
Sbjct: 348 EQMQEQEEKMWEQEEKMREQEEKMWRQEER-LWEQEKQMREQEQKMRDQEERMWEQDERL 406
Query: 341 LDQRRRMMEEKLLHAE---FKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLS 397
++ RM E++ + + + E ++Q KK +++E K+ E I E + K +
Sbjct: 407 REKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIR--EREKKMREEEE 464
Query: 398 KLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRAL-EAERQARVEELLMKRKEQEARI 456
++E E+++ + QEE QEEK+ + + + E+K L E E+ EE K EQE +I
Sbjct: 465 TMREQEEKMQK-QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE---KIWEQEEKI 520
Query: 457 EQQ-----------RQEKEKAREDAARERAR----------DREERLAALTAAQ------ 489
Q RQEK + +ED E+ D+EER+ T Q
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
Query: 490 -------QEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPY 542
+E M E +KK++ + +E +R E++++++EK E + +
Sbjct: 581 QEEKMREEERMREREKKMR-EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQE---- 635
Query: 543 ERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDI 602
+ +K + E ++ + + ++ + E+ +Q +E E+ E + ++ +
Sbjct: 636 QEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695
Query: 603 VVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRL 662
E + E + +++ KK++ ++ E + E + K+Q
Sbjct: 696 TQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE---------KMQEQ 746
Query: 663 AKDLLKQVQ---VQDSGSWANNKVSALDRTLGEITRILEKENVADQ 705
+++ +Q + Q+ W ++ L E ++ E+E + +Q
Sbjct: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQ 792
Score = 84.3 bits (207), Expect = 6e-16
Identities = 96/456 (21%), Positives = 211/456 (46%), Gaps = 65/456 (14%)
Query: 294 IAESKKKHEEKQMKAQQLREK-LREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEE-- 350
+ E K+K E + Q++ L+EE + ++L E+EK +RK +E++ Q R+ E+
Sbjct: 248 VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEG 307
Query: 351 KLLHAE---FKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLN 407
K+ E +++E +L+ K+ +E+E ++ E + E Q + + K+ E E+++
Sbjct: 308 KMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQE--EKMWEQEEKMR 365
Query: 408 ELQEERQRRQEEK---QARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKE 464
E QEE+ RQEE+ Q + QE+K + ER +E L +++E+ E+ ++ E
Sbjct: 366 E-QEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVE 424
Query: 465 KARED----AARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKE 520
K RE+ ++ RD+EE++ ++E + E +KK++ + +E++R E++++++E
Sbjct: 425 KMREEKKMQEQEKKTRDQEEKM-----QEEERIREREKKMR-EEEETMREQEEKMQKQEE 478
Query: 521 KAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSI 580
E ++ + P +++K L E K + ++ +R+ +
Sbjct: 479 NMWE-----QEEKEWQQQRLPEQKEK-------LWEQEKMQEQEEKIWEQEEKIRDQEEM 526
Query: 581 QGREL-----------------SDEEVEHLSLKKYIIDIVVESTAPAEALK--DGEER-- 619
G+E +E++ K + + +E + K D EE+
Sbjct: 527 WGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMR 586
Query: 620 --QKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYK-----AKLQRLAKDLLKQVQ- 671
++ +++ KK++ ++ E + E + + K K+Q + + +Q +
Sbjct: 587 EEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
Query: 672 --VQDSGSWANNKVSALDRTLGEITRILEKENVADQ 705
Q+ W ++ L E ++ E+E + +Q
Sbjct: 647 MWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ 682
Score = 80.1 bits (196), Expect = 1e-14
Identities = 91/378 (24%), Positives = 166/378 (43%), Gaps = 45/378 (11%)
Query: 150 EKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIE 209
EK EK E E D M E +E + +R +K EE EE+ +E
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQE----EERIREREKKMREEEETMREQEEKMQKQEEN 479
Query: 210 AEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTS-WGDIVE 268
E + + + + W + E W Q W +
Sbjct: 480 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWR---Q 536
Query: 269 EEPARPPGHGIHMHEKLSSPSRKRTIAESK--KKHEEKQMKAQQLREKLREEKTLKLQKL 326
E+ EK+ +K E + KK +E++ K EK+REE+ ++
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMR---- 592
Query: 327 LEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
EREK +R+ +E + +Q +M E+ E ++Q +K E+E K+ E
Sbjct: 593 -EREKKMREEEEMMREQEEKMQEQ---------EEKMQEQEEKMWEQEEKMQE------- 635
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELL 446
+ K + K+ E E+++ E ++R Q+EK E +QE+++ E E + +E
Sbjct: 636 -QEEKMWEQEEKMWEQEEKMWE--QQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK- 691
Query: 447 MKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDE 506
M++K QE E++ ++EK RE+ E R+RE+++ ++E M E ++K+Q + +E
Sbjct: 692 MEKKTQEQ--EKKTWDQEKMREE---ESMREREKKM----REEEEMMREQEEKMQ-EQEE 741
Query: 507 SIRRHMEQIEQRKEKAAE 524
++ E++ +++EK E
Sbjct: 742 KMQEQEEEMWEQEEKMWE 759
Score = 75.5 bits (184), Expect = 3e-13
Identities = 82/386 (21%), Positives = 168/386 (43%), Gaps = 46/386 (11%)
Query: 149 EEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREI 208
E+K ++ E E + M + K + +R+EK +E +EE++ E
Sbjct: 530 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEE 589
Query: 209 EAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVE 268
E E + M + + + + E + ++ W E
Sbjct: 590 RMREREKKMREEEE-----------------MMREQEEKMQEQEEKMQEQEEKMW----E 628
Query: 269 EEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQL----REKLRE-EKTLKL 323
+E EK+ K E K +E++M QQ +EKL E EK +
Sbjct: 629 QE------------EKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 676
Query: 324 QKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFI 383
+K+ E+E+ + W++E ++++ + E+K E RE + +K EE ++
Sbjct: 677 EKMQEQEEKI--WEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE 734
Query: 384 NTLEAQNKRHDVLSKLKEYEQRLNELQE---ERQR--RQEEKQARDEAVQERKRALEAER 438
E + K + ++ E E+++ E +E E+QR Q+EK E +QE+++ E E
Sbjct: 735 KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEE 794
Query: 439 QARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQK 498
+ R +E M+ +E++ R ++++ ++ + E+ +EE++ E++++
Sbjct: 795 KMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEE 854
Query: 499 KIQLKHDESIRRHMEQIEQRKEKAAE 524
K+Q +E +R E++ ++EK E
Sbjct: 855 KMQ-GQEEKMREQEEKMRGQEEKMRE 879
Score = 70.5 bits (171), Expect = 9e-12
Identities = 80/366 (21%), Positives = 166/366 (45%), Gaps = 50/366 (13%)
Query: 149 EEKFPAEKARIENEMDPSDISN-SMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTRE 207
E+K ++ R+E + + E + ++E + +R +K EE EE+ +E
Sbjct: 557 EQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE 616
Query: 208 IEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIV 267
+ +E + E + + + + + E + ++ W
Sbjct: 617 EKMQEQEEKMWEQEEKMQ-----------------EQEEKMWEQEEKMWEQEEKMW---- 655
Query: 268 EEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQL------REKLREEKTL 321
E++ + HEK+ + + E + E+ + K Q+ +EK+REE+++
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM 715
Query: 322 KLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIA 381
+ EREK +R+ +E + +Q +M E++ E + E+ Q +K E+E K+ E
Sbjct: 716 R-----EREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQE--EKMWEQEEKMWEQQ 768
Query: 382 FINTLEAQNKRHDVL---SKLKEYEQRLNELQEERQRRQEEKQARDEAV---QERKRALE 435
+ + + H+ + K+ E E+++ + QEE+ R QEEK E QE K +
Sbjct: 769 RLPEQKEKLWEHEKMQEQEKIWEQEEKMRD-QEEKMRGQEEKMRGQEEKMRGQEEKMWGQ 827
Query: 436 AERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEE 495
E+ EE + ++E+ E++ +EK + +E E+ R++EE++ Q+E M E
Sbjct: 828 EEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE----EKMREQEEKM----RGQEEKMRE 879
Query: 496 LQKKIQ 501
++K++
Sbjct: 880 QEEKMR 885
Score = 57.4 bits (137), Expect = 8e-08
Identities = 87/399 (21%), Positives = 180/399 (45%), Gaps = 57/399 (14%)
Query: 323 LQKLLEREKDVRKWKEELLDQRRRMMEE----KLLHAEFKRE-VQLQAIVKKAQEEEAKV 377
L + R K ++ EEL +R + E + + E K++ +LQ + A+ E++++
Sbjct: 185 LSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEI 244
Query: 378 NEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAE 437
+N E + K L + + N LQEE R++EE + QE+K + E
Sbjct: 245 Q----LNVKELKRKLERAKFLLPQVQT--NTLQEEMWRQEEELRE-----QEKKIRKQEE 293
Query: 438 RQARVEELLMKRKEQEARIEQQ-----RQEKEKAREDAARERARDREERLAALTAAQQEA 492
+ R EE L +EQE ++ +Q RQEK + RE R +++E R Q+E
Sbjct: 294 KMWRQEERL---REQEGKMREQEEKMWRQEK-RLREQEKELREQEKELREQKELREQEEQ 349
Query: 493 MEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCN 552
M+E ++K+ + +E +R E++ +++E+ E ++ E+K +
Sbjct: 350 MQEQEEKM-WEQEEKMREQEEKMWRQEERLWEQEK----------QMREQEQKMRDQEER 398
Query: 553 VLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEA 612
+ E + R+ ++ +RE +E E+VE + +K + + ++ E
Sbjct: 399 MWEQDE-------RLREKEERMRE------QEKMWEQVEKMREEKKMQEQEKKTRDQEEK 445
Query: 613 LKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLK---- 668
+++ E ++ +KK ++ + M R +E + + +N + + QRL + K
Sbjct: 446 MQEEERIREREKKMREEEETM--REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ 503
Query: 669 -QVQVQDSGSW-ANNKVSALDRTLGEITRILEKENVADQ 705
++Q Q+ W K+ + G+ ++ +E + +Q
Sbjct: 504 EKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 542
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 87.0 bits (214), Expect = 9e-17
Identities = 70/244 (28%), Positives = 139/244 (56%), Gaps = 16/244 (6%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLL-EREKDVRKWKEELL 341
E+L +K E K +E++++ Q+ + + +EEK + +K L E+EK++R+ ++EL
Sbjct: 241 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELR 300
Query: 342 DQRR-RMMEEKLLHAE---FKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLS 397
+Q++ R EE++ E +++E +++ +K +E ++ E E + K D
Sbjct: 301 EQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE-QEKQMREQEQKMRDQEE 359
Query: 398 KLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIE 457
++ E ++RL E +EER R QE+ ++E +QE +R E E++ R EE M +EQE +++
Sbjct: 360 RMWEQDERLRE-KEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM--REQEEKMQ 416
Query: 458 QQRQEK-EKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+Q + E+ ++ ++R +++E+L +QE M+E ++KI + +E IR E
Sbjct: 417 KQEENMWEQEEKEWQQQRLPEQKEKL-----WEQEKMQEQEEKI-WEQEEKIRDQEEMWG 470
Query: 517 QRKE 520
Q K+
Sbjct: 471 QEKK 474
Score = 82.0 bits (201), Expect = 3e-15
Identities = 83/369 (22%), Positives = 169/369 (45%), Gaps = 45/369 (12%)
Query: 294 IAESKKKHEEKQMKAQQLREK-LREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKL 352
+ E K+K E + Q++ L+EE + ++L E+EK +RK +E++ Q R+ E++
Sbjct: 210 VKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEG 269
Query: 353 LHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEE 412
E + +++ Q + QE+E + E L Q K + +++E E+++ E QEE
Sbjct: 270 KMREQEEKMRRQEKRLREQEKELREQE----KELREQKKLREQEEQMQEQEEKMWE-QEE 324
Query: 413 RQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAAR 472
+ R QEEK R E +R E E+Q M+ +EQ+ R +++R ++ R
Sbjct: 325 KMREQEEKMWRQE-----ERLWEQEKQ-------MREQEQKMRDQEERMWEQDERLREKE 372
Query: 473 ERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHAN 532
ER R++E+ Q+E ++K + +E++R E++++++E E
Sbjct: 373 ERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE-----QEE 427
Query: 533 TDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRE-------- 584
++ + P +++K L E K + ++ +R+ + G+E
Sbjct: 428 KEWQQQRLPEQKEK-------LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK 480
Query: 585 -------LSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRA 637
+ ++E + ++ + D E L++ EER + +KK + + +M
Sbjct: 481 MREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK 540
Query: 638 KEYESLMET 646
K E +T
Sbjct: 541 KTQEQEKKT 549
Score = 80.9 bits (198), Expect = 7e-15
Identities = 96/411 (23%), Positives = 186/411 (45%), Gaps = 51/411 (12%)
Query: 268 EEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKL-QKL 326
+E+ R + EK +K E + + +E++M Q+ + + +EEK + ++L
Sbjct: 281 QEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 340
Query: 327 LEREKDVRKWKEELLDQRRRMME--EKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFIN 384
E+EK +R+ ++++ DQ RM E E+L E + Q +K E+E K+ E I
Sbjct: 341 WEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ-----EKMWEQEEKMQEEERIR 395
Query: 385 TLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRAL-EAERQARVE 443
E + K + ++E E+++ + QEE QEEK+ + + + E+K L E E+ E
Sbjct: 396 --EREKKMREEEETMREQEEKMQK-QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQE 452
Query: 444 ELLMKRKEQEARIEQQ-----------RQEKEKARED---AARERARDREERLAALTAAQ 489
E K EQE +I Q RQEK + +ED E+ RD+E+++ Q
Sbjct: 453 E---KIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM----WDQ 505
Query: 490 QEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCS 549
+E M E ++ L+ E R +++ Q++EK E K T + KK
Sbjct: 506 EERMWEQDER--LREKEERMREQKKMWQQEEKMRE------------EKKTQEQEKKTWD 551
Query: 550 LCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAP 609
+ E K R+ ++ +RE Q ++ ++E + ++ + + +
Sbjct: 552 QEEKMREEERMREREKKMREEEEMMRE----QEEKMQEQEEKMREQEEKMWEQEEKMQEQ 607
Query: 610 AEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ 660
E + + EE+ +++ K++ + ++ E + E + + K + Q
Sbjct: 608 EEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Score = 80.5 bits (197), Expect = 9e-15
Identities = 91/386 (23%), Positives = 172/386 (44%), Gaps = 33/386 (8%)
Query: 149 EEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREI 208
E + EK E E D M E + E +R+ + + +EE+ RE
Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER 397
Query: 209 EA---EENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD 265
E EE + + + +M +W + + W Q
Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQE------EKEWQQQRLPEQKEKLWEQEKMQE- 450
Query: 266 IVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQK 325
+EE I E++ +K E K + +E QM Q+ EK+R+++ QK
Sbjct: 451 --QEEKIWEQEEKIRDQEEMWGQEKKMWRQE-KMREQEDQMWEQE--EKMRDQE----QK 501
Query: 326 LLEREKDVRKWKEELLDQRRRMMEEKLL---HAEFKREVQLQAIVKKAQEEEAKVNEIAF 382
+ ++E+ + + E L ++ RM E+K + + + E + Q KK ++E K+ E
Sbjct: 502 MWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEER 561
Query: 383 INTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ-ARDEAVQERKRAL-EAERQA 440
+ E + K + ++E E+++ E QEE+ R QEEK ++E +QE++ + E E +
Sbjct: 562 MR--EREKKMREEEEMMREQEEKMQE-QEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKM 618
Query: 441 RVEELLMKRKEQEARIEQQRQEKEKARED--AARERARDREERL---AALTAAQQEAMEE 495
+E K +EQE + +Q ++ ++ E E+ R++EE++ Q+E M E
Sbjct: 619 WEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMRE 678
Query: 496 LQKKIQLKHDESIRRHMEQIEQRKEK 521
++K+Q +E +R E++ ++EK
Sbjct: 679 QEEKMQ-GQEEKMREQEEKMRGQEEK 703
Score = 78.6 bits (192), Expect = 3e-14
Identities = 72/240 (30%), Positives = 125/240 (52%), Gaps = 30/240 (12%)
Query: 290 RKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMME 349
+K+ + +K EEK+ + Q+ + +EEK + +++ EREK +R+ +E + +Q +M E
Sbjct: 526 QKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE 585
Query: 350 --EKLLHAEFK---REVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQ 404
EK+ E K +E ++Q +K E+E K+ E E ++K + + E E+
Sbjct: 586 QEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWE------QEEEDKMQEQEEMMWEQEE 639
Query: 405 RLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKE 464
++ E QEE+ QEEK E E+ R E + Q + E K +EQE +++ Q +E
Sbjct: 640 KMQE-QEEKMWEQEEKMREQE---EKMREQEEKMQGQEE----KMREQEEKMQGQ---EE 688
Query: 465 KAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAE 524
K RE E+ R +EE++ Q+E M ++K + E +R E+I +KEK E
Sbjct: 689 KMREQ--EEKMRGQEEKM----WGQEEKMWGQEEK--MWGQEEMREKEERIRDQKEKMQE 740
Score = 77.4 bits (189), Expect = 7e-14
Identities = 63/311 (20%), Positives = 153/311 (49%), Gaps = 18/311 (5%)
Query: 252 EARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQL 311
E + W Q + EEE R + E+ ++ + + E+++ + QQ
Sbjct: 377 EQEKMWEQEEK---MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 433
Query: 312 REKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFK---REVQLQAIVK 368
R ++EK + +K+ E+E+ + + +E++ DQ +EK + + K +E Q+ +
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 493
Query: 369 KAQEEEAKV--NEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARD-- 424
K +++E K+ E E ++ + + + K+ Q+ +++EE++ +++EK+ D
Sbjct: 494 KMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQE 553
Query: 425 EAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAA 484
E ++E +R E E++ R EE +M+ +E++ + ++++ +++ + E+ +++EE++
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613
Query: 485 LTAA--QQEAMEELQKKIQL------KHDESIRRHMEQIEQRKEKAAELSSGRHANTDYA 536
+QE +++Q++ ++ K E + EQ E+ +E+ ++
Sbjct: 614 QEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE 673
Query: 537 PKLTPYERKKQ 547
K+ E K Q
Sbjct: 674 EKMREQEEKMQ 684
Score = 55.1 bits (131), Expect = 4e-07
Identities = 52/203 (25%), Positives = 104/203 (51%), Gaps = 24/203 (11%)
Query: 331 KDVRKWKEELLDQRRRMMEE----KLLHAEFKRE-VQLQAIVKKAQEEEAKVNEIAFINT 385
K ++ EEL +R + E + + E K++ +LQ ++ A+ E++++ +N
Sbjct: 155 KKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQ----LNV 210
Query: 386 LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEEL 445
E + K L + + N LQEE R++EE + QE+K + E+ R EE
Sbjct: 211 KELKRKLERAKFLLPQVQT--NTLQEEMWRQEEELRE-----QEKKIRKQEEKMWRQEER 263
Query: 446 LMKRKEQEARIEQQ----RQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQ 501
L +EQE ++ +Q R+++++ RE R +++E R Q+E M+E ++K+
Sbjct: 264 L---REQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKM- 319
Query: 502 LKHDESIRRHMEQIEQRKEKAAE 524
+ +E +R E++ +++E+ E
Sbjct: 320 WEQEEKMREQEEKMWRQEERLWE 342
Score = 52.4 bits (124), Expect = 2e-06
Identities = 48/230 (20%), Positives = 110/230 (47%), Gaps = 35/230 (15%)
Query: 252 EARESWRQNTSWGDI--VEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQ 309
E ++ W+Q + +E+ + M E+ R++ + E ++ E++ K Q
Sbjct: 525 EQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 584
Query: 310 QLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEE----KLLHAE---FKREVQ 362
+ EK+RE++ +K+ E+E+ +++ +E++ +Q +M E+ K+ E +++E +
Sbjct: 585 EQEEKMREQE----EKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEK 640
Query: 363 LQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNEL------------- 409
+Q +K E+E K+ E E + K K++E E+++
Sbjct: 641 MQEQEEKMWEQEEKMREQEE-KMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRG 699
Query: 410 -------QEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQ 452
QEE+ QEEK E ++E++ + +++ +++E L + +E+
Sbjct: 700 QEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKE-KMQERLPEHEER 748
Score = 47.4 bits (111), Expect = 8e-05
Identities = 101/513 (19%), Positives = 198/513 (38%), Gaps = 109/513 (21%)
Query: 270 EPARPPGHGIHMHEKLSSPSRKRTIAESKKKH---------------------------- 301
+P PP H +S +R+ +AE+KKK
Sbjct: 4 QPHLPP------HPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTRATDTKKKKINNGTN 57
Query: 302 ------------EEKQMKAQQLREKLREE--------KTLKLQK------LLEREKDVRK 335
E+++ + Q +E LR E + L QK L + RK
Sbjct: 58 PETTTSEGCHSPEDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARK 117
Query: 336 WKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDV 395
+++ L + + + LH + +LQ + K + +E K D
Sbjct: 118 FEDGNLGESKDLAGR--LHHSWHFAGELQRALSAVSTWHKKADRY-----IEELTKERDA 170
Query: 396 LS--------KLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAER------QAR 441
LS +E +++ ELQE+ + + EK V+E KR LE + Q
Sbjct: 171 LSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTN 230
Query: 442 VEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQ 501
+ M R+E+E R ++++ K++ + ER R++E ++ Q+E M +K+++
Sbjct: 231 TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKM----REQEEKMRRQEKRLR 286
Query: 502 LKHDESIRRHMEQIEQRK--EKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEV 559
+ E + E EQ+K E+ ++ + K+ E K + E
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEK--------MWRQEE 338
Query: 560 YLFSHVKG-RKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEE 618
L+ K R+ +Q +R+ E E+ E L K+ + + E +++ E
Sbjct: 339 RLWEQEKQMREQEQKMRDQ-----EERMWEQDERLREKEERMREQEKMWEQEEKMQEEER 393
Query: 619 RQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLK-----QVQVQ 673
++ +KK ++ + M R +E + + +N + + QRL + K ++Q Q
Sbjct: 394 IREREKKMREEEETM--REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 451
Query: 674 DSGSW-ANNKVSALDRTLGEITRILEKENVADQ 705
+ W K+ + G+ ++ +E + +Q
Sbjct: 452 EEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ 484
Score = 42.7 bits (99), Expect = 0.002
Identities = 46/210 (21%), Positives = 81/210 (38%), Gaps = 17/210 (8%)
Query: 149 EEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREI 208
EEK E+ E E + M E K +E +++ + E+ +EQ +
Sbjct: 553 EEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMW 612
Query: 209 EAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARES-WRQNTSWGDIV 267
E EE E D + M W E E W Q +
Sbjct: 613 EQEEKMWEQEEEDKMQEQEEMM-------------WEQEEKMQEQEEKMWEQEEKMRE-- 657
Query: 268 EEEPARPPGHGIH-MHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKL 326
+EE R + EK+ K E K + +E++M+ Q+ + +EEK ++
Sbjct: 658 QEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEK 717
Query: 327 LEREKDVRKWKEELLDQRRRMMEEKLLHAE 356
+ ++++R+ +E + DQ+ +M E H E
Sbjct: 718 MWGQEEMREKEERIRDQKEKMQERLPEHEE 747
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 87.0 bits (214), Expect = 9e-17
Identities = 130/547 (23%), Positives = 242/547 (44%), Gaps = 83/547 (15%)
Query: 123 EISAVHIDTECVSVMLQAGTPPLQVNEEKFPA-EKARIENEMDPSDISNSMAEVLAKKEE 181
E + D E V+V P + NEE+F + +K + + ++ +E L K+
Sbjct: 68 EAQGIKADRETVAVK------PTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
Query: 182 LADRLEKANEEAIASAIAEEE--QLTREIE--AEENNDINIETDNDSDFSASMGSGS-VS 236
+ + K E + + +++ +L ++ + A+++N ++ D D S + S ++
Sbjct: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRIN 181
Query: 237 FCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRK-RTIA 295
G S D +D ++R+ ++N PG I + S K +T+A
Sbjct: 182 SSGESGDESDEFL--QSRKGQKKNQK----------NKPGPNIESGNEDDDASFKIKTVA 229
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREK-DVRKWKEELLDQRRRMMEEKLLH 354
+ K + +E++ K R+E+ KL+KL E+E+ + K + + +R EE+ +
Sbjct: 230 QKKAEKKERERKK-------RDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETV- 281
Query: 355 AEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQ 414
K +V + V A EE+A+ A + E K+ D K E E++ E ++
Sbjct: 282 ---KSKVTVDTGVIPASEEKAETPTAAEDDN-EGDKKKKDKKKKKGEKEEKEKEKKKGPS 337
Query: 415 RR----QEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDA 470
+ +E A+ + +ER++ E ER R+EEL KRKE+E R+EQ+++E++K +E
Sbjct: 338 KATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE-RLEQEKRERKKQKEKE 396
Query: 471 ARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRH 530
+ER + +E +L LT +Q+EA + ++L + + E+ S
Sbjct: 397 RKERLK-KEGKL--LTKSQREARARAEATLKLLQAQGV---------------EVPS--- 435
Query: 531 ANTDYAPKLTP-YERKKQCSLCNVLISSEV----YLFSHVKGRKHQQAVRENTSIQGREL 585
D PK P YE KK+ + L S EV L + V+ + +E T
Sbjct: 436 --KDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPE 493
Query: 586 SDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLME 645
+E+ E L + EA+ EE +K + I+ + N +E E E
Sbjct: 494 EEEDTEDAGLDDW------------EAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEE 541
Query: 646 TKNSGSD 652
++ S+
Sbjct: 542 EEDEESE 548
Score = 44.3 bits (103), Expect = 7e-04
Identities = 51/247 (20%), Positives = 102/247 (41%), Gaps = 28/247 (11%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKL---QKLLEREKDVRKWKEE 339
EK +K + + K E K + Q + R E TLKL Q + KD K
Sbjct: 385 EKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRP 444
Query: 340 LL-DQRRRMMEEKLLHAEFKREVQLQAIVKKAQE--------------EEAKVNEIAFIN 384
+ D++R+ + ++L E ++L A V+ ++ EE + E A ++
Sbjct: 445 IYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD 504
Query: 385 TLEAQ---NKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQAR 441
EA + V E + N +EE + +EE+ E +E + E
Sbjct: 505 DWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDE 564
Query: 442 VEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQ 501
+E + K+ ++++ ++ + + + R +EER A +A ++K+ +
Sbjct: 565 EDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEER------AYDKAKRRIEKR-R 617
Query: 502 LKHDESI 508
L+H +++
Sbjct: 618 LEHSKNV 624
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 86.7 bits (213), Expect = 1e-16
Identities = 105/413 (25%), Positives = 191/413 (46%), Gaps = 61/413 (14%)
Query: 138 LQAGTPPLQVNEEKF--PAEKARIENEM--DPSDISNSMAEVLAKKEELADRLEKA---N 190
+Q ++ EEK EK R + EM + + E++ +KEE R E+
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 375
Query: 191 EEAIA---SAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDV 247
EE + + E+E+ RE+E + + I + +
Sbjct: 376 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK-----------------RQEEEK 418
Query: 248 LADYEARES-----WRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHE 302
+ + E R+ WRQ + +EE R + E+ K I E +K+ E
Sbjct: 419 IREQEKRQEQEAKMWRQEEKIRE--QEEKIREQEKKMWRQEEKIHEQEK--IREEEKRQE 474
Query: 303 EKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLLHAEFKRE 360
+++M Q+ + +EE + +K+ E+E+ +RK +E++ Q ++ EEK+ E K
Sbjct: 475 QEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMW 534
Query: 361 VQLQAIVKKAQ--EEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQE 418
Q + I ++ + EE K++E + + KR + K+ E+++ E QEE+ RQE
Sbjct: 535 RQEEKIREQEEMWREEEKMHEQ---EKIWEEEKRQEQEDKMWRQEEKIRE-QEEKVWRQE 590
Query: 419 EKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQ----RQEKEKAREDAARER 474
EK QE KR + E+ + EE K +EQE +I++Q R+++EK RE E
Sbjct: 591 EKIRE----QEEKRQEQEEKMWKQEE---KIREQEEKIQEQEEKIREQEEKIREQ--EEM 641
Query: 475 ARDREERLA---ALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAE 524
+++EE++ Q+E M+E Q++ + +E IR ++I +++EK E
Sbjct: 642 TQEQEEKMGEQEEKMCEQEEKMQE-QEETMWRQEEKIREQEKKIREQEEKIRE 693
Score = 81.3 bits (199), Expect = 5e-15
Identities = 95/387 (24%), Positives = 184/387 (47%), Gaps = 45/387 (11%)
Query: 155 EKARIENEM--DPSDISNSMAEVLAKKEELADRLEKA---NEEAIASA---IAEEEQLTR 206
EK R + EM + + E++ +KEE R E+ EE I + E+E++
Sbjct: 349 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 408
Query: 207 EIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD- 265
+ E + + E + + A M + + + + E ++ WRQ +
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKI----REQEEKIREQE-KKMWRQEEKIHEQ 463
Query: 266 --IVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKL-REEKTLK 322
I EEE + EK+ + I K+K E++ K ++ EK+ R+E+ ++
Sbjct: 464 EKIREEEKRQEQEEMWRQEEKIHE---QEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520
Query: 323 LQKLLEREKDVRKWKEE--LLDQRRRMMEEKLLHAEFK--REVQLQAIVKKAQEEEAKVN 378
Q+ RE++ + W++E + +Q EE+ +H + K E + Q K +E K+
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIR 580
Query: 379 EIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEK-QARDEAVQERKRALEAE 437
E + K K++E E++ E QEE+ +QEEK + ++E +QE++ + E
Sbjct: 581 E--------QEEKVWRQEEKIREQEEKRQE-QEEKMWKQEEKIREQEEKIQEQEEKIR-E 630
Query: 438 RQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQ 497
++ ++ E +EQE E+ +++EK E E+ +++EE + Q+E + E +
Sbjct: 631 QEEKIREQEEMTQEQE---EKMGEQEEKMCEQ--EEKMQEQEETM----WRQEEKIREQE 681
Query: 498 KKIQLKHDESIRRHMEQIEQRKEKAAE 524
KKI+ + +E IR E +++++EK E
Sbjct: 682 KKIR-EQEEKIREQEEMMQEQEEKMWE 707
Score = 79.3 bits (194), Expect = 2e-14
Identities = 64/231 (27%), Positives = 124/231 (53%), Gaps = 12/231 (5%)
Query: 298 KKKHEEKQMKAQQLREKLRE--EKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHA 355
++K +E + K Q+ EK+RE EK + ++ + R++++ KEE + ++ MM EK
Sbjct: 306 EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 365
Query: 356 EFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQR 415
+ E+ + K ++EE + I LE K H+ K++E E++ QEE +
Sbjct: 366 RRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE--EKMHEQ-EKIREQEEKR---QEEEKI 419
Query: 416 RQEEKQARDEAV--QERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARE 473
R++EK+ EA ++ ++ E E + R +E M R+E++ +++ +E+EK +E
Sbjct: 420 REQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMW 479
Query: 474 RARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAE 524
R ++ + Q+E M E ++KI+ K +E + R E+I +++EK E
Sbjct: 480 RQEEKIHEQEEIW-RQKEKMHEQEEKIR-KQEEKVWRQEEKIREQEEKIRE 528
Score = 77.0 bits (188), Expect = 9e-14
Identities = 96/400 (24%), Positives = 178/400 (44%), Gaps = 90/400 (22%)
Query: 149 EEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIA-----SAIAEEEQ 203
EEK ++ R E E A++ ++E++ ++ EK E+ I E+E+
Sbjct: 416 EEKIREQEKRQEQE----------AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 465
Query: 204 LTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSW 263
+ E + +E ++ W +E E WRQ
Sbjct: 466 IREEEKRQEQEEM---------------------------WRQEEKIHEQEEIWRQKEKM 498
Query: 264 GDIVEEEPARPPGHGI-HMHEKLSSPSRKRTIAESKKKHEEKQMKAQQL----------R 312
+ +EE R + EK+ K E K +E++++ Q+ +
Sbjct: 499 HE--QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQ 556
Query: 313 EKLREEKTLKLQ--KLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKA 370
EK+ EE+ + Q K+ +E+ +R+ +E++ Q EEK+ E KR+ Q + + K
Sbjct: 557 EKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQ-----EEKIREQEEKRQEQEEKMWK-- 609
Query: 371 QEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDE---AV 427
QEE+ + E + K + K++E E+++ E QEE + QEEK E
Sbjct: 610 QEEKIR----------EQEEKIQEQEEKIREQEEKIRE-QEEMTQEQEEKMGEQEEKMCE 658
Query: 428 QERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERAR---DREERLAA 484
QE K + E R EE K +EQE +I +Q +EK + +E+ +E+ ++EE++
Sbjct: 659 QEEKMQEQEETMWRQEE---KIREQEKKIREQ-EEKIREQEEMMQEQEEKMWEQEEKM-- 712
Query: 485 LTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAE 524
Q+E M+E ++K++ + +E + ++ Q++EK E
Sbjct: 713 --CEQEEKMQEQEEKMR-RQEEKMWEQEVRLRQQEEKMQE 749
Score = 72.8 bits (177), Expect = 2e-12
Identities = 109/526 (20%), Positives = 230/526 (43%), Gaps = 70/526 (13%)
Query: 150 EKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIE 209
E+ E+ + E+ + I++ E+ K +L ++L+ E + +E L R++E
Sbjct: 196 EELTKERDALSLELYRNTITDE--ELKEKNAKLQEKLQLVESEKSEIQLNVKE-LKRKLE 252
Query: 210 AEE----NNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTS--- 262
+ + E D+ S+ + + + WN L + + WRQ
Sbjct: 253 RAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNR-LNQQQEEKMWRQEEKIQE 311
Query: 263 WGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLK 322
W + ++E+ EK+ K E K + +E+ M ++ + + +EE +
Sbjct: 312 WEEKIQEQ-----------EEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 323 LQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAF 382
++ + R++++ KEE + ++ MM EK E +++ + +K E+E K+ E
Sbjct: 361 KEEKMRRQEEMMWEKEEKMRRQEEMMWEK--------EEKIRELEEKMHEQE-KIRE--- 408
Query: 383 INTLEAQNKRHDVLSKLKEYEQRLNE-----LQEERQRRQEEKQARDEAVQERKRALEAE 437
Q ++ K++E E+R + QEE+ R QEEK R+ QE+K + E
Sbjct: 409 ------QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK-IRE---QEKKMWRQEE 458
Query: 438 RQARVEELLMKRKEQEARIEQQRQEKEKAREDAAR--ERARDREERLAALTAAQQEAMEE 495
+ E++ + K QE +++EK +E+ R E+ ++EE++ Q+E +
Sbjct: 459 KIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKI----RKQEEKVWR 514
Query: 496 LQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLI 555
++KI+ + +E IR E++ +++EK E + +E +K+ + +
Sbjct: 515 QEEKIR-EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMW 573
Query: 556 SSEVYLFSHVKGRKHQQAV-RENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALK 614
E K R+ ++ V R+ I+ +E +E E K+ E + K
Sbjct: 574 RQE------EKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ-------EEKIREQEEK 620
Query: 615 DGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ 660
E+ +K +++ +KI+ + ++ E + E + + K + Q
Sbjct: 621 IQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 666
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 85.9 bits (211), Expect = 2e-16
Identities = 69/266 (25%), Positives = 146/266 (54%), Gaps = 29/266 (10%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLL-EREKDVRKWKEELL 341
EK+ K E K + +E++M+ Q+ +EEK + ++++ E+E+ +R+ +E++
Sbjct: 295 EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 354
Query: 342 DQRR-------RMMEEKLLHAEFKRE--VQLQAIVKKAQEEEAKVNEIAFINTLEAQNKR 392
+Q + R EEK+ E ++E ++ +K +E+E K+ E + E + K
Sbjct: 355 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQ-EQEEKM 413
Query: 393 HDVLSKLKEYEQRLNELQEERQRRQEEK--------QARDEAVQERKRALEAERQARVEE 444
+ K+ E E+ + E QEE+ RRQEEK + ++E ++E++ ++ E++ ++ E
Sbjct: 414 GEQEEKMWEQEEEMQE-QEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ-EQEEKMGE 471
Query: 445 LLMKRKEQEARIEQQ----RQEKEKAREDAARERARDREERLAALTAAQQEAMEEL--QK 498
K EQEA++++Q R+++EK RE ++ R++EE++ QE E++ Q+
Sbjct: 472 QEGKMCEQEAKMQEQEEKMRRQEEKIREQ--EKKIREQEEKIREQEEMMQEQEEKMWEQE 529
Query: 499 KIQLKHDESIRRHMEQIEQRKEKAAE 524
+ + +E ++ E++ +++EK E
Sbjct: 530 EKMCEQEEKMQEQEEKMRRQEEKMRE 555
Score = 82.8 bits (203), Expect = 2e-15
Identities = 90/397 (22%), Positives = 183/397 (46%), Gaps = 48/397 (12%)
Query: 147 VNEEKFPAEKARIEN-----EMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEE 201
+ +E+ + A+++ E + S+I ++ E+ K E L + +A A + +E
Sbjct: 202 ITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 261
Query: 202 EQLTR---EIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWR 258
Q + + EEN N + + + + + E + +
Sbjct: 262 LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQ 321
Query: 259 QNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREE 318
+ W EE+ R EK+ K E ++ EEK+ + +++RE+ E+
Sbjct: 322 EEMMWEK--EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ--EK 377
Query: 319 KTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAE-----FKREVQLQAIVKKAQEE 373
+ + K+ +E+ +R+ +E++ +Q M E++ E +++E ++Q +K + +
Sbjct: 378 RQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQ 437
Query: 374 EAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDE---AVQER 430
E K+ E Q K K++E E+++ E QEE + QEEK E QE
Sbjct: 438 EEKIRE---------QEK------KIREQEEKIRE-QEEMMQEQEEKMGEQEGKMCEQEA 481
Query: 431 KRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERAR---DREERLAALTA 487
K + E+ R EE K +EQE +I +Q +EK + +E+ +E+ ++EE++
Sbjct: 482 KMQEQEEKMRRQEE---KIREQEKKIREQ-EEKIREQEEMMQEQEEKMWEQEEKM----C 533
Query: 488 AQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAE 524
Q+E M+E ++K++ + +E +R ++ Q++EK E
Sbjct: 534 EQEEKMQEQEEKMR-RQEEKMREQEVRLRQQEEKMQE 569
Score = 74.7 bits (182), Expect = 5e-13
Identities = 86/387 (22%), Positives = 177/387 (45%), Gaps = 67/387 (17%)
Query: 281 MHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKD-------- 332
+ EK + K + ES+K E Q+ ++L+ KL K L Q+ L+ E D
Sbjct: 207 LKEKNAKLQEKLQLVESEKS--EIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQS 264
Query: 333 ------VRKWKEELLDQRRRMMEEKLLHAEFK---REVQLQAIVKKAQEEEAKVN--EIA 381
+ + EL ++ + EEK+ E K RE ++Q +K +E+E K+ E
Sbjct: 265 VSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEM 324
Query: 382 FINTLEAQNKRHDVL----SKLKEYEQRLNELQ-----------EERQRRQEEKQARDEA 426
E ++ +++ K++E E++++E + EE+ R QE++Q ++
Sbjct: 325 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK 384
Query: 427 V-QERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAAL 485
+ ++ ++ E E + R +E +M+ +E E+ +++EK E E +++EE++
Sbjct: 385 MWRQEEKIREQEEKIREQEEMMQEQE-----EKMGEQEEKMWEQ--EEEMQEQEEKM--- 434
Query: 486 TAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERK 545
Q+E + E +KKI+ + +E IR E +++++EK E K+ E K
Sbjct: 435 -RRQEEKIREQEKKIR-EQEEKIREQEEMMQEQEEKMGEQEG----------KMCEQEAK 482
Query: 546 KQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVE 605
Q + E K R+ ++ +RE E+ E+ E + ++ + + E
Sbjct: 483 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-----EEMMQEQEEKMWEQE---EKMCE 534
Query: 606 STAPAEALKDGEERQKNKKKAKKIKAR 632
+ ++ RQ+ K + ++++ R
Sbjct: 535 QEEKMQEQEEKMRRQEEKMREQEVRLR 561
Score = 58.5 bits (140), Expect = 3e-08
Identities = 77/367 (20%), Positives = 169/367 (46%), Gaps = 47/367 (12%)
Query: 304 KQMKAQQLREKLREEK---TLKLQKLLEREKDVRKWKEELLDQRRRMMEEK----LLHAE 356
++ KA + E+L +E+ +L+L + ++++++ +L ++ + + EK L E
Sbjct: 175 QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKE 234
Query: 357 FKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYE--QRLNELQEERQ 414
KR+++ ++ Q+ +A+ + + E Q+ + ++++E E RLN+ QEE+
Sbjct: 235 LKRKLERAKLLLPQQQLQAEADHLG----KELQSVSAKLQAQVEENELWNRLNQQQEEKM 290
Query: 415 RRQEEK-QARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQ------RQEKEKAR 467
RQEEK Q R+E +QE++ K +EQE ++ +Q ++EK + +
Sbjct: 291 WRQEEKIQEREEKIQEQEE---------------KIREQEEKMRRQEEMMWEKEEKMRRQ 335
Query: 468 ED---AARERARDREERL---AALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEK 521
E+ E+ R+ EE++ + +++ EE + + Q K E + Q E+ +E+
Sbjct: 336 EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 395
Query: 522 AAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTS-- 579
++ + K+ E K + E K R+ ++ +RE
Sbjct: 396 EEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKI 455
Query: 580 IQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKAR-MNFRAK 638
+ E+ E+ E + ++ + E A + ++ RQ+ K + ++ K R + +
Sbjct: 456 REQEEMMQEQEEKMGEQE---GKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 512
Query: 639 EYESLME 645
E E +M+
Sbjct: 513 EQEEMMQ 519
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 82.0 bits (201), Expect = 3e-15
Identities = 145/709 (20%), Positives = 300/709 (42%), Gaps = 116/709 (16%)
Query: 38 KVSLATEATRSKDDSDKENVCLLPDESIQKG-QFVGDGTSNTIESHPKDSLHSCDHPLAE 96
+V LA +A++ +++ D NV L +E+ +KG +F D S +ES +D+ +
Sbjct: 1275 RVELAEKASKLQNELD--NVSTLLEEAEKKGIKFAKDAAS--LESQLQDTQELLQEETRQ 1330
Query: 97 KTQFT--VSTLDDVKNSGSIRDNYVRTSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPA 154
K + + L++ KNS E + +++ + +++ Q +V+++
Sbjct: 1331 KLNLSSRIRQLEEEKNS---LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTI 1387
Query: 155 EKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENN 214
E + + ++L E L+ RLE E+A+A E+ T+ +E +
Sbjct: 1388 ES-----------LEEAKKKLLKDAEALSQRLE---EKALAYDKLEK---TKNRLQQELD 1430
Query: 215 DINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADY----------------------- 251
D+ ++ D+ ++++ F + + + A Y
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490
Query: 252 ------EARESW-RQNTSWGDIVEEEPARPPGHGIHMHE-KLSSPSRKRTIAESKKKHEE 303
EA+E + RQN +E+ + G ++HE + S + ++ + E + + EE
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEE 1550
Query: 304 KQMKAQQLRE-KLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEE-KLLHAEFKREV 361
+ + Q + KLR E ++ K + E+D++ E+ +++R ++++ + L AE + E
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKA-QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDER 1609
Query: 362 QLQAIV---KKAQEEEAKVNEIAFINTLEAQNK-RHDVLSKLKEYEQRLNELQ---EERQ 414
+ +A+ KK E + K E +EA NK R +V+ +L++ + ++ + Q EE +
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQ----IEAANKARDEVIKQLRKLQAQMKDYQRELEEAR 1665
Query: 415 RRQEEKQARDEAVQERKRALEAERQARVEELL-MKRKEQEARIEQQRQEKEKAREDAARE 473
++E A+ + +++ ++LEAE EEL +R + A E+ E + +
Sbjct: 1666 ASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKS 1725
Query: 474 RARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANT 533
D + RL A A +E +EE Q ++L +D + ++ E AAE S+ + ++
Sbjct: 1726 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSD- 1784
Query: 534 DYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHL 593
QQ R+N ++ + +E+E
Sbjct: 1785 ----------------------------------NARQQLERQNKELKAKL---QELEGA 1807
Query: 594 SLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDS 653
K+ I + + E+ K + A K+ R + KE +E + +D
Sbjct: 1808 VKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQ 1867
Query: 654 PYKAKLQRL---AKDLLKQV-QVQDSGSWANNKVSALDRTLGEITRILE 698
YK ++++ K L +Q+ + ++ + AN L R L + T E
Sbjct: 1868 -YKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANE 1915
Score = 73.6 bits (179), Expect = 1e-12
Identities = 142/687 (20%), Positives = 273/687 (39%), Gaps = 108/687 (15%)
Query: 145 LQVNEE---KFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEE 201
LQ +E K ++ ++E E++ ++ ++L +K LA++L+ E AE
Sbjct: 854 LQAKDEELLKVKEKQTKVEGELE--EMERKHQQLLEEKNILAEQLQAETE-----LFAEA 906
Query: 202 EQLTREIEAEEN------NDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARE 255
E++ + A++ +D+ + + + + + + M D+ + E
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK---MQAHIQDLEEQLDEEE 963
Query: 256 SWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRT------IAESKKKHEEKQMKAQ 309
RQ + E + I + E +S K IAE + E++ KA+
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 310 QLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKL--------LHAEF---- 357
L K+R ++ + + L ER K K ++EL +R++ E L A+
Sbjct: 1024 NLA-KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082
Query: 358 ----KREVQLQAIVKKAQEEEA-KVNEIAFINTLEAQ-------------------NKRH 393
K+E +LQ + + +E K N + + L+AQ ++
Sbjct: 1083 LQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR 1142
Query: 394 DVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQE 453
D+ +L+ + L + + +QE + R++ V E K+ALE E + ++ R+
Sbjct: 1143 DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA 1202
Query: 454 ARIEQQRQEKEKAR------EDAARERARDREERLAALTAAQQEAMEELQKKIQLKHD-E 506
+E+ ++ E+A+ E + D +E + QQ E K+ +L +
Sbjct: 1203 TALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262
Query: 507 SIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKK-------QCSLCNVLISSEV 559
+ + + ++ + + AE +S D L KK SL + L ++
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322
Query: 560 YLFSHVKGR-----KHQQAVRENTSIQGRELSDEEV------EHLSLKKYIIDI---VVE 605
L + + + +Q E S+Q ++ +EE + L+L+ + D V +
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 606 STAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKD 665
E+L+ E ++K K A+ + R+ +A Y+ L +TKN + +L L D
Sbjct: 1383 DLGTIESLE--EAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR-----LQQELDDLTVD 1435
Query: 666 LLKQVQVQDSGSWANNKVSALDRTLGE----ITRILEKENVADQIA----FQAAGGLTAL 717
L Q QV S K D+ L E R E+ + A+ A +A AL
Sbjct: 1436 LDHQRQV---ASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492
Query: 718 EHILQAVVPATNVNTVLRIPPKSLCNA 744
E L+A N LR + L ++
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSS 1519
Score = 62.0 bits (149), Expect = 3e-09
Identities = 78/376 (20%), Positives = 174/376 (46%), Gaps = 57/376 (15%)
Query: 307 KAQQLREKLREEKTLK-----LQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREV 361
K + L + R+E+ L+ L K+ E++ V EE+ + ++++EEK + AE
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAE----- 894
Query: 362 QLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQ---- 417
QLQA + E E +A E + HD+ S+++E E+R LQ E+++ Q
Sbjct: 895 QLQAETELFAEAEEMRARLA-AKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQ 953
Query: 418 ------EEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAA 471
+E++ + +Q K EA+ + EE+L+ + I++++ +++ E ++
Sbjct: 954 DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSS 1013
Query: 472 R-ERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQR--------KEKA 522
+ ++ + LA + Q+ + +L+++ LK +E R+ +E+ +++ +++
Sbjct: 1014 QLAEEEEKAKNLAKIRNKQEVMISDLEER--LKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 523 AELSSGRHANTDYAPKLTPYERKKQCSLC-------------NVLISSEVYLFSHVKGRK 569
AEL + + +L E + Q +L V+ + + + +
Sbjct: 1072 AELQA---QIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFE 1128
Query: 570 HQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKI 629
++A R Q R+LS+E L K ++ +++TA + L R K +++ ++
Sbjct: 1129 SEKASRNKAEKQKRDLSEE----LEALKTELEDTLDTTAAQQEL-----RTKREQEVAEL 1179
Query: 630 KARMNFRAKEYESLME 645
K + K +E+ ++
Sbjct: 1180 KKALEEETKNHEAQIQ 1195
Score = 53.5 bits (127), Expect = 1e-06
Identities = 96/459 (20%), Positives = 196/459 (42%), Gaps = 53/459 (11%)
Query: 160 ENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIA--------SAIAEEEQLTREIEAE 211
E E + + E+ + EEL D L+ + + A E + TR+ + E
Sbjct: 1529 ELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE 1588
Query: 212 ENNDINIETDND-----SDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDI 266
E + I+ + D S M +D D+ A EA R
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVI--KQ 1646
Query: 267 VEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEE-KQMKAQ--QLREKLREEKTLKL 323
+ + A+ + + E + SR A+SK+ ++ K ++A+ QL+E+L + +
Sbjct: 1647 LRKLQAQMKDYQRELEE--ARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARR 1704
Query: 324 QKLLEREK------DVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKV 377
ER++ + K LLD++RR+ R QL+ +++ Q +
Sbjct: 1705 HAEQERDELADEITNSASGKSALLDEKRRLEA---------RIAQLEEELEEEQSNMELL 1755
Query: 378 NEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAE 437
N+ TL+ ++ ++ + Q+ + +++ +R+ +E +A+ +QE + A++++
Sbjct: 1756 NDRFRKTTLQVDTLNAELAAE-RSAAQKSDNARQQLERQNKELKAK---LQELEGAVKSK 1811
Query: 438 RQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAAL-TAAQQEAMEEL 496
+A + L K + E ++EQ+ +E+ AA + R E++L + + E
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERA-----AANKLVRRTEKKLKEIFMQVEDERRHAD 1866
Query: 497 QKKIQL-KHDESIRRHMEQIEQRKEKAAELSSGR---HANTDYAPKLTPYERKKQCSLCN 552
Q K Q+ K + +++ Q+E+ +E+A ++ R D A + ++ +L N
Sbjct: 1867 QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKN 1926
Query: 553 VLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVE 591
L FS + + Q + E S+ ELSD++ E
Sbjct: 1927 RLRRGGPISFSSSRSGRRQLHL-EGASL---ELSDDDTE 1961
>gi|219803769 trichoplein [Homo sapiens]
Length = 498
Score = 81.3 bits (199), Expect = 5e-15
Identities = 113/472 (23%), Positives = 213/472 (45%), Gaps = 83/472 (17%)
Query: 254 RESWRQNTSW---GDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQ 310
R+ W QN+ + DI + A +S R + +K EEK+ +
Sbjct: 31 RQQWEQNSRYFRMSDICSSKQAE--------WSSKTSYQRSMHAYQREKMKEEKRRSLEA 82
Query: 311 LREKLR----EEKTLKLQKLLE-------REKDVRKWKEEL---LDQRRRMMEEKLLHAE 356
REKLR EE+ L ++L E +E+ +R+ +L +++R+++ E+LL+
Sbjct: 83 RREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEH 142
Query: 357 FK------REVQLQAIVK------KAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYE- 403
+K RE++L K + Q+EE K E T E +NKR++ EYE
Sbjct: 143 WKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA----TAEQENKRYE-----NEYER 193
Query: 404 ---QRLNELQEERQRRQEEKQARDEAVQERKRAL-----EAERQARVEELLMKRKEQEAR 455
+ L ++ E +RRQ E + + EA+ ++ L EA + + +E L+K++ + R
Sbjct: 194 ARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
Query: 456 IEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQL------KHDESIR 509
+E++R++ E R+ A R R + A L+ Q+ EEL+ ++ K DES R
Sbjct: 254 LEEERKQMEAFRQKAELGRFL-RHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQR 312
Query: 510 RHM---EQI-------EQRKEKAAELSSGRHANTDYAPKLTPYE--RKKQCSLCNVLISS 557
H+ EQ+ +Q E+ +L R A + E K++ +
Sbjct: 313 LHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSAR 372
Query: 558 EVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
+ + + GR QQ ++E Q R +E ++H ++ +I + E A K+
Sbjct: 373 DRLMSEVLTGR--QQQIQEKIE-QNRRAQEESLKH---REQLIRNLEEVRELARREKEES 426
Query: 618 ERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQ 669
E+ K+ +K + R + +E+ + + ++ ++++L+ LL+Q
Sbjct: 427 EKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA---RRVEQLSDALLQQ 475
Score = 64.3 bits (155), Expect = 6e-10
Identities = 77/306 (25%), Positives = 144/306 (47%), Gaps = 43/306 (14%)
Query: 282 HEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ--KLLEREKDVRK--WK 337
+E+ + +R AE +++ E +++A+ L +++ E K +++ KL + ++++ K W+
Sbjct: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
Query: 338 EELLDQRRRMMEEKLLHAEFKR------EVQLQAIVKKAQEE---EAKVNEIAFINTLEA 388
E L++ R+ ME AE R QL ++ QEE + ++ + E+
Sbjct: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
Query: 389 QN----KRHDVLSKLKEYEQRLNE-LQEERQRRQEEKQARDEAVQERKRALEAE----RQ 439
Q +R V++ + +Q + E LQ ER R E + E +E EAE R
Sbjct: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
Query: 440 AR---VEELLMKRKEQ-EARIEQQRQEKE---KARE------DAARERARDREERLAALT 486
AR + E+L R++Q + +IEQ R+ +E K RE + RE AR +E L
Sbjct: 371 ARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLK 430
Query: 487 AAQQEAMEE--LQKKIQL----KHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
+A+++ +E ++++Q + +E ++EQ + + + A Y PK
Sbjct: 431 SARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK-- 488
Query: 541 PYERKK 546
PY K
Sbjct: 489 PYGHPK 494
Score = 38.9 bits (89), Expect = 0.029
Identities = 62/318 (19%), Positives = 132/318 (41%), Gaps = 38/318 (11%)
Query: 403 EQRLNEL------QEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARI 456
+QRLN+ QE R R+Q E+ +R + + + +AE ++ Q ++
Sbjct: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
Query: 457 EQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+++++ +AR + R+ ++ ++ LA +EEL+ + L+ + IR +++
Sbjct: 73 KEEKRRSLEARREKLRQLMQEEQDLLA-------RELEELRLSMNLQ-ERRIREQHGKLK 124
Query: 517 QRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRE 576
KE+ +L + ++ K P R+ + L HQ+ V
Sbjct: 125 SAKEEQRKLIA-EQLLYEHWKKNNPKLREMELDL-------------------HQKHVVN 164
Query: 577 NTSIQGRELSDEE-VEHLSLKKYIIDIVVESTAPAEALKDGEERQ--KNKKKAKKIKARM 633
+ +Q E +E K+Y + E +K EER+ ++K +A+ + +M
Sbjct: 165 SWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQM 224
Query: 634 -NFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWANNKVSALDRTLGE 692
+ KE E+ K + + +L+RL ++ + + + L
Sbjct: 225 EELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSR 284
Query: 693 ITRILEKENVADQIAFQA 710
T+ +++E AD+ QA
Sbjct: 285 RTQQIQEELEADRRILQA 302
>gi|14150056 trichoplein [Homo sapiens]
Length = 498
Score = 81.3 bits (199), Expect = 5e-15
Identities = 113/472 (23%), Positives = 213/472 (45%), Gaps = 83/472 (17%)
Query: 254 RESWRQNTSW---GDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQ 310
R+ W QN+ + DI + A +S R + +K EEK+ +
Sbjct: 31 RQQWEQNSRYFRMSDICSSKQAE--------WSSKTSYQRSMHAYQREKMKEEKRRSLEA 82
Query: 311 LREKLR----EEKTLKLQKLLE-------REKDVRKWKEEL---LDQRRRMMEEKLLHAE 356
REKLR EE+ L ++L E +E+ +R+ +L +++R+++ E+LL+
Sbjct: 83 RREKLRQLMQEEQDLLARELEELRLSMNLQERRIREQHGKLKSAKEEQRKLIAEQLLYEH 142
Query: 357 FK------REVQLQAIVK------KAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYE- 403
+K RE++L K + Q+EE K E T E +NKR++ EYE
Sbjct: 143 WKKNNPKLREMELDLHQKHVVNSWEMQKEEKKQQEA----TAEQENKRYE-----NEYER 193
Query: 404 ---QRLNELQEERQRRQEEKQARDEAVQERKRAL-----EAERQARVEELLMKRKEQEAR 455
+ L ++ E +RRQ E + + EA+ ++ L EA + + +E L+K++ + R
Sbjct: 194 ARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWELER 253
Query: 456 IEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQL------KHDESIR 509
+E++R++ E R+ A R R + A L+ Q+ EEL+ ++ K DES R
Sbjct: 254 LEEERKQMEAFRQKAELGRFL-RHQYNAQLSRRTQQIQEELEADRRILQALLEKEDESQR 312
Query: 510 RHM---EQI-------EQRKEKAAELSSGRHANTDYAPKLTPYE--RKKQCSLCNVLISS 557
H+ EQ+ +Q E+ +L R A + E K++ +
Sbjct: 313 LHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERSAR 372
Query: 558 EVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
+ + + GR QQ ++E Q R +E ++H ++ +I + E A K+
Sbjct: 373 DRLMSEVLTGR--QQQIQEKIE-QNRRAQEESLKH---REQLIRNLEEVRELARREKEES 426
Query: 618 ERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQ 669
E+ K+ +K + R + +E+ + + ++ ++++L+ LL+Q
Sbjct: 427 EKLKSARKQELEAQVAERRLQAWEADQQEEEEEEEA---RRVEQLSDALLQQ 475
Score = 64.3 bits (155), Expect = 6e-10
Identities = 77/306 (25%), Positives = 144/306 (47%), Gaps = 43/306 (14%)
Query: 282 HEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ--KLLEREKDVRK--WK 337
+E+ + +R AE +++ E +++A+ L +++ E K +++ KL + ++++ K W+
Sbjct: 191 YERARREALERMKAEEERRQLEDKLQAEALLQQMEELKLKEVEATKLKKEQENLLKQRWE 250
Query: 338 EELLDQRRRMMEEKLLHAEFKR------EVQLQAIVKKAQEE---EAKVNEIAFINTLEA 388
E L++ R+ ME AE R QL ++ QEE + ++ + E+
Sbjct: 251 LERLEEERKQMEAFRQKAELGRFLRHQYNAQLSRRTQQIQEELEADRRILQALLEKEDES 310
Query: 389 QN----KRHDVLSKLKEYEQRLNE-LQEERQRRQEEKQARDEAVQERKRALEAE----RQ 439
Q +R V++ + +Q + E LQ ER R E + E +E EAE R
Sbjct: 311 QRLHLARREQVMADVAWMKQAIEEQLQLERAREAELQMLLREEAKEMWEKREAEWARERS 370
Query: 440 AR---VEELLMKRKEQ-EARIEQQRQEKE---KARE------DAARERARDREERLAALT 486
AR + E+L R++Q + +IEQ R+ +E K RE + RE AR +E L
Sbjct: 371 ARDRLMSEVLTGRQQQIQEKIEQNRRAQEESLKHREQLIRNLEEVRELARREKEESEKLK 430
Query: 487 AAQQEAMEE--LQKKIQL----KHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
+A+++ +E ++++Q + +E ++EQ + + + A Y PK
Sbjct: 431 SARKQELEAQVAERRLQAWEADQQEEEEEEEARRVEQLSDALLQQEAETMAEQGYRPK-- 488
Query: 541 PYERKK 546
PY K
Sbjct: 489 PYGHPK 494
Score = 38.9 bits (89), Expect = 0.029
Identities = 62/318 (19%), Positives = 132/318 (41%), Gaps = 38/318 (11%)
Query: 403 EQRLNEL------QEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARI 456
+QRLN+ QE R R+Q E+ +R + + + +AE ++ Q ++
Sbjct: 13 QQRLNQQLARQREQEARLRQQWEQNSRYFRMSDICSSKQAEWSSKTSYQRSMHAYQREKM 72
Query: 457 EQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+++++ +AR + R+ ++ ++ LA +EEL+ + L+ + IR +++
Sbjct: 73 KEEKRRSLEARREKLRQLMQEEQDLLA-------RELEELRLSMNLQ-ERRIREQHGKLK 124
Query: 517 QRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRE 576
KE+ +L + ++ K P R+ + L HQ+ V
Sbjct: 125 SAKEEQRKLIA-EQLLYEHWKKNNPKLREMELDL-------------------HQKHVVN 164
Query: 577 NTSIQGRELSDEE-VEHLSLKKYIIDIVVESTAPAEALKDGEERQ--KNKKKAKKIKARM 633
+ +Q E +E K+Y + E +K EER+ ++K +A+ + +M
Sbjct: 165 SWEMQKEEKKQQEATAEQENKRYENEYERARREALERMKAEEERRQLEDKLQAEALLQQM 224
Query: 634 -NFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWANNKVSALDRTLGE 692
+ KE E+ K + + +L+RL ++ + + + L
Sbjct: 225 EELKLKEVEATKLKKEQENLLKQRWELERLEEERKQMEAFRQKAELGRFLRHQYNAQLSR 284
Query: 693 ITRILEKENVADQIAFQA 710
T+ +++E AD+ QA
Sbjct: 285 RTQQIQEELEADRRILQA 302
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 80.5 bits (197), Expect = 9e-15
Identities = 100/442 (22%), Positives = 186/442 (42%), Gaps = 62/442 (14%)
Query: 149 EEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREI 208
E + P EK + + P E +A E+L++ KA EEA+A + ++++ E
Sbjct: 555 EAEDPEEKVAV-SPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLES 613
Query: 209 EAEENNDINIET--DNDSDFSASMGSGSVSFCGMSMDWNDVLADYEAR--ESWRQNTSWG 264
+ E+ + + + + + S + + + EAR E Q SW
Sbjct: 614 KQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWL 673
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPS-RKRTIAESKKKHEEKQMKAQQLREKLREE----- 318
+ + I ++ S R+ ++ K + + K +Q+ E+L+EE
Sbjct: 674 RAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASE 733
Query: 319 ----------KTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHA-EFKREVQLQAIV 367
K LQ+L E+ + RK L++ E+L + E K + ++
Sbjct: 734 KSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQ 793
Query: 368 KKAQEEEAK-----------VNEIAFINTLEAQNKRHDVLSKLKE--------YEQRLNE 408
KK QE + K V + H++ S L+E +E+RL++
Sbjct: 794 KKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDK 853
Query: 409 LQEERQRRQEEKQARDEAVQERKRA---------LEAERQARVEELLMKRKEQEARIEQQ 459
++EE Q+ + + + EA + ++RA LE ++A EL R+EQ R+E
Sbjct: 854 MKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDL 913
Query: 460 RQ---EKEKAREDAARE---RARDREERLAALTAAQQEAMEE------LQKKIQLKHDES 507
R+ E+E+ +D + RA+D + RLA L ++ A E +Q+++ LK +E+
Sbjct: 914 RRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEA 973
Query: 508 IRRHMEQIEQRKEKAAELSSGR 529
H + E +KE L S +
Sbjct: 974 TATHQQLEEAQKEHTHLLQSNQ 995
Score = 67.0 bits (162), Expect = 1e-10
Identities = 88/395 (22%), Positives = 174/395 (44%), Gaps = 49/395 (12%)
Query: 283 EKLSSPSRKRTIAESKKKHEEK------QMKAQQLREKLREEKTLKLQKLLEREKDVRKW 336
++ +PS + K++H + Q +A+ EK+ T + + + V
Sbjct: 525 QREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAP- 583
Query: 337 KEELLDQRRRMMEEKLLHA---------EFKREVQLQAIVKKAQEEEAKVNEIAFINTLE 387
E+L + + MEE + E K+E Q K QEEE ++ L
Sbjct: 584 PEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEI--------LR 635
Query: 388 AQNKRHDVLSKLKEYEQRLNELQEERQRRQEEK---------QARDEAVQERKRA-LEAE 437
++ LS L+E Q+ E +E R R +E + Q+ +A +++ RA EA
Sbjct: 636 LHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS 695
Query: 438 RQARVEELLMKRKEQEARIEQQ-RQEKEKAREDAARERARDREERLAALTAAQQEAMEEL 496
Q EEL ++K + A +EQ+ RQ E+ +E+ A ++ E+ AAL AA+++A+++L
Sbjct: 696 LQKLREELESQQKAERASLEQKNRQMLEQLKEEI---EASEKSEQ-AALNAAKEKALQQL 751
Query: 497 QKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHAN--TDYAPKLTPYERKKQCSL--CN 552
+++++ + E++ ++ E+ +H + K+ ++K++ L C
Sbjct: 752 REQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCL 811
Query: 553 VLISSEVYLFS-HVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAE 611
+ V+ S HV G +H E +S+ + + E EH + + + A A
Sbjct: 812 GQVEHRVHQKSYHVAGYEH-----ELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAR 866
Query: 612 ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMET 646
+ EER++ + + + + +E +ET
Sbjct: 867 EQYEAEERKQRAELLGHLTGELERLQRAHERELET 901
Score = 57.0 bits (136), Expect = 1e-07
Identities = 110/589 (18%), Positives = 239/589 (40%), Gaps = 66/589 (11%)
Query: 141 GTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEK----ANEEAIAS 196
G+ P + +E++ P E+ +D + + E + ++ A LE+ A++E S
Sbjct: 336 GSEPAKASEKEAP------EDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEIS 389
Query: 197 AIAEEEQLTREIEAEENNDINIETDN---------DSDFSASMGSGSVSFCGMSMDWNDV 247
+E QL+ I ++ + ++ D D + + G+ + D
Sbjct: 390 EHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDK 449
Query: 248 LADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMK 307
+++ + S G +EE + P H E+ SP R E + E Q +
Sbjct: 450 DDSQSSQDELQSKQSKG--LEERLSPPLPH----EERAQSPPRSLATEEEPPQGPEGQPE 503
Query: 308 AQQLREKLREEK--TLKLQKLLEREKD------VRKWKEELLDQRRRMMEEKLLHAEFKR 359
++ E+L E+ +L LQ L+RE+ K KE+ EE E
Sbjct: 504 WKEA-EELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQ-----HSQAEELGPGQEEAE 557
Query: 360 EVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEE 419
+ + + V +V + E ++ + LK E+ + ++ E+ QR E
Sbjct: 558 DPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSE-----AALKAMEEAVAQVLEQDQRHLLE 612
Query: 420 KQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDRE 479
++ E +Q+ + L E + EE+L +++E + R+ +KA E+ +
Sbjct: 613 --SKQEKMQQLREKLCQEEE---EEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEES 667
Query: 480 ERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE--QRKEKAAELSSGRHANTDYAP 537
+RL+ L A Q + + + +I+ + + S+++ E++E Q+ E+A+ R
Sbjct: 668 QRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKE 727
Query: 538 KLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAV---RENTSIQGRELSDEEVEHLS 594
++ E+ +Q +L + L ++G + + +E+++ R S E +H
Sbjct: 728 EIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHRE 787
Query: 595 LKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYE----SLMETKNSG 650
+ + + E+ EA + QK + + + ++ YE SL+ K
Sbjct: 788 VVSSLQKKIQEAQQKEEA-----QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQE 842
Query: 651 SDSPYKAKLQRLAKD---LLKQVQVQDSGSWANNKVSALDRTLGEITRI 696
+ ++ +L ++ ++ ++ + + Q + L GE+ R+
Sbjct: 843 VEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERL 891
Score = 56.2 bits (134), Expect = 2e-07
Identities = 77/390 (19%), Positives = 161/390 (41%), Gaps = 53/390 (13%)
Query: 179 KEELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFC 238
+EE + RL + +S A+E+Q+ E EA + + +S A S
Sbjct: 663 REEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQK---LREELESQQKAERASLEQKNR 719
Query: 239 GMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGH---GIHMHEKLSSPSRKRTIA 295
M + + E E N + +++ + G + EK S +R +
Sbjct: 720 QMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCS 779
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQKLL--------EREKDVRKWKEELLDQRRRM 347
+ KH E Q+ ++ ++++ +LQK L ++ V ++ EL +
Sbjct: 780 SLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSS----L 835
Query: 348 MEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKL-------- 399
+ EK E + E +L + ++ Q+ AK E E + +R ++L L
Sbjct: 836 LREKRQEVEGEHERRLDKMKEEHQQVMAKAREQY---EAEERKQRAELLGHLTGELERLQ 892
Query: 400 KEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMK----------- 448
+ +E+ L +++E+ +R E+ + R + + + LE + + R +++ +
Sbjct: 893 RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETA 952
Query: 449 RKEQEARIEQQRQEKEKAREDAAR----ERARDREERLAALTAAQQEAMEELQ-KKIQLK 503
R+E++ ++ QRQ K+ E A E A+ L +E ++ELQ +K++L+
Sbjct: 953 RREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLE 1012
Query: 504 --------HDESIRRHMEQIEQRKEKAAEL 525
+ +++H +E +K L
Sbjct: 1013 SQVDLLQAQSQQLQKHFSSLEAEAQKKQHL 1042
Score = 45.4 bits (106), Expect = 3e-04
Identities = 105/563 (18%), Positives = 225/563 (39%), Gaps = 92/563 (16%)
Query: 44 EATRSKDDSDKENVCLLPDESIQKGQFVGDGTSNTIESHPKDSLHSCDHPLAEKTQFTVS 103
E+ + K +E +C +E I + + + +++ + ++ + + E+ +S
Sbjct: 612 ESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLS 671
Query: 104 TLD-DVKNSGSIRDNYVRTSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENE 162
L V++S ++ +R + +++ E + +A L E+K +++ E
Sbjct: 672 WLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASL---EQKNRQMLEQLKEE 728
Query: 163 MDPSDISNSMAEVLAKK---EELADRLEKANEEAIASA----IAEEEQLTREIEAEENND 215
++ S+ S A AK+ ++L ++LE +EA+A+ AE E+L +EA+
Sbjct: 729 IEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREV 788
Query: 216 INI------ETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEE 269
++ E + G V ++ ++E R+ VE
Sbjct: 789 VSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQE---VEG 845
Query: 270 EPARPPGHGIHMHEKLSSPSRKRTIAESKKKH--------------------------EE 303
E R H+++ + +R++ AE +K+ +E
Sbjct: 846 EHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQE 905
Query: 304 KQMKAQQLREKLREEKTLKLQKL---LE-REKDVRKWKEELLDQRRRMMEEKLLHAEFKR 359
+ + + LR + RE++ KLQ L LE R KDV+ L Q EK + +R
Sbjct: 906 QHKRLEDLRRRHREQER-KLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQR 964
Query: 360 EVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLK----EYEQRLNELQEERQR 415
+V L++ A ++ + + + L++ + ++L +L+ + E +++ LQ + Q+
Sbjct: 965 QVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQ 1024
Query: 416 RQ----------EEKQ--ARDEAVQERKRALEAERQARVEEL-----LMKRKEQEARIEQ 458
Q ++KQ R+ V+E + E +E+L + KE + + Q
Sbjct: 1025 LQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQ 1084
Query: 459 QRQE--------------------KEKAREDAARERARDREERLAALTAAQQEAMEELQK 498
+++ ++ ++ ++ R R AL AAQQ EL
Sbjct: 1085 SKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS 1144
Query: 499 KIQLKHDESIRRHMEQIEQRKEK 521
++ D + +E + + EK
Sbjct: 1145 AQEVAKDPPGIKALEDMRKNLEK 1167
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 78.2 bits (191), Expect = 4e-14
Identities = 121/609 (19%), Positives = 254/609 (41%), Gaps = 55/609 (9%)
Query: 155 EKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIAS-AIAEEEQLTREIEAEEN 213
EK R + E D +D+S+ +AE+ A+ EL +L K EE A+ A EEE + + ++
Sbjct: 1047 EKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI 1106
Query: 214 NDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPAR 273
++ + S+ + S S D+ + EA ++ ++T ++E
Sbjct: 1107 RELESQI---SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQE--- 1160
Query: 274 PPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDV 333
+ + K+T+ E K HE + + +Q + EE +L++ + ++
Sbjct: 1161 -----LRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL 1215
Query: 334 RKWKEELLDQRRRMMEE-KLL--------HAEFKREVQLQAIVKKAQEEEAKVNEIAFIN 384
K K+ L ++R + E K+L H K E QLQ + K E E E+A
Sbjct: 1216 EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELA-DK 1274
Query: 385 TLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEE 444
+ Q + +V L + + + ++L ++ + + Q E +QE R ++ +
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR-----QKLSLST 1329
Query: 445 LLMKRKEQEARIEQQRQEKEKAREDAARERA----------RDREERLAALTAAQQEAME 494
L + ++++ +Q +E+E+A+ + ++ A + E+ + L A +E
Sbjct: 1330 KLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETA-EEVKR 1388
Query: 495 ELQKKIQ---LKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLC 551
+LQK ++ +H+E + + +++E+ K + + + D+ + KKQ
Sbjct: 1389 KLQKDLEGLSQRHEEKVAAY-DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFD 1447
Query: 552 NVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELS---------DEEVEHLSLKKYIIDI 602
+L + + + R +A + L+ E+E L+ K++ ++
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN-KQFRTEM 1506
Query: 603 VVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRL 662
++ + K E +K+K+ ++ M + +E E ++ + + LQ +
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQA-TEDAKLRLEVNLQAM 1565
Query: 663 AKDLLKQVQVQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQAAGGLTALEHILQ 722
+ +Q +D S K L R + E+ LE E +A A L L+
Sbjct: 1566 KAQFERDLQGRDEQS--EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE 1623
Query: 723 AVVPATNVN 731
A + + N N
Sbjct: 1624 AHIDSANKN 1632
Score = 75.9 bits (185), Expect = 2e-13
Identities = 128/549 (23%), Positives = 226/549 (41%), Gaps = 82/549 (14%)
Query: 168 ISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENNDINIETDNDSDFS 227
+S E++AK+EEL EK + A + + E E L ++ AE+ + + +++
Sbjct: 840 VSRQEEEMMAKEEELVKVREK--QLAAENRLTEMETLQSQLMAEKLQ-LQEQLQAETELC 896
Query: 228 ASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHGIHMHEKLSS 287
A + ++ D EAR VEEE R H+
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEAR------------VEEEEERCQ----HLQ----- 935
Query: 288 PSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLER---EKDVRKWKEE---LL 341
AE KK Q Q+L E+L EE++ + + LE+ E ++K +EE L
Sbjct: 936 -------AEKKKM----QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILE 984
Query: 342 DQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKE 401
DQ ++ +EK L E ++ EEE K +A + +NK +++ L+E
Sbjct: 985 DQNCKLAKEKKL-----LEDRIAEFTTNLTEEEEKSKSLA-----KLKNKHEAMITDLEE 1034
Query: 402 YEQRLNELQEERQRRQEEKQARD-EAVQERKRALEAERQARVEELLMK--RKEQEARIEQ 458
+R EE+QR++ EK R E AE QA++ EL M+ +KE+E +
Sbjct: 1035 RLRR-----EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL 1089
Query: 459 QRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHD-----ESIRRHME 513
R E+E A+++ A ++ R+ E +++ L + K + K D E+++ +E
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE 1149
Query: 514 QIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQA 573
EL S R + K E K + + +KH QA
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM------------RQKHSQA 1197
Query: 574 VRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARM 633
V E + Q + + K+ + + E + L G+ ++K+ KK++A++
Sbjct: 1198 V-EELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKR--KKVEAQL 1254
Query: 634 NFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWANNK-VSALDRTLGE 692
++ + +D KLQ ++ + DS S K SAL+ L +
Sbjct: 1255 QELQVKFNEGERVRTELADK--VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Query: 693 ITRILEKEN 701
+L++EN
Sbjct: 1313 TQELLQEEN 1321
Score = 67.4 bits (163), Expect = 7e-11
Identities = 87/415 (20%), Positives = 188/415 (45%), Gaps = 57/415 (13%)
Query: 307 KAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKRE-VQLQA 365
K + L + R+E ++++ +E+++ K +E+ L R+ E + L ++ E +QLQ
Sbjct: 833 KVKPLLQVSRQE-----EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQE 887
Query: 366 IVKKAQEEEAKVNEIAFINTLEAQNKR---HDVLSKLKEYEQRLNELQEERQRRQEEKQA 422
++ E A+ E+ T + Q HD+ ++++E E+R LQ E+++ Q+
Sbjct: 888 QLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQN--- 944
Query: 423 RDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDR---E 479
+QE + LE E AR ++L +++ EA++ ++ +E++ ED + A+++ E
Sbjct: 945 ----IQELEEQLEEEESAR-QKLQLEKVTTEAKL-KKLEEEQIILEDQNCKLAKEKKLLE 998
Query: 480 ERLAALTA--AQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHA----NT 533
+R+A T ++E + K++ KH+ I E++ + +++ EL R +T
Sbjct: 999 DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDST 1058
Query: 534 DYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQ------------ 581
D + ++ E + Q + + ++ + R ++A ++N +++
Sbjct: 1059 DLSDQIA--ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 582 GRELSDEEVEHLSLKKYIIDIVVESTAPAEALKD--------GEERQKNKKKAKKIKARM 633
+L E +K D+ E A L+D E R K +++ +K +
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 634 NFRAKEYESL---METKNSGSDSPYKAKLQRLAK-----DLLKQVQVQDSGSWAN 680
AK +E+ M K+S + +L++ + + KQ + G AN
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Score = 57.0 bits (136), Expect = 1e-07
Identities = 86/380 (22%), Positives = 180/380 (47%), Gaps = 39/380 (10%)
Query: 150 EKFPAEKARIENEMDPS----DISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLT 205
+K K R++ E+D D A L KK++ D+L A E+ I++ AEE
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQL-LAEEKTISAKYAEERDRA 1467
Query: 206 REIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD 265
E EA E + ++S + + A+ E R + + T D
Sbjct: 1468 -EAEAREKE-----------------TKALSLARALEEAMEQKAELE-RLNKQFRTEMED 1508
Query: 266 IVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLRE-KLREEKTLKLQ 324
++ + G +H EK S + ++ + E K + EE + + Q + KLR E L+
Sbjct: 1509 LMSSKD--DVGKSVHELEK-SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 325 KLLEREKDVRKWKEELLDQRRRMMEE-KLLHAEFKREVQLQAIVKKAQEE-EAKVNEI-A 381
K + E+D++ E+ +++++++ + + + AE + E + +++ A+++ E + ++ A
Sbjct: 1566 KA-QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 382 FINTLEAQNKRHDVLSKLKEYEQRLNELQEE---RQRRQEEKQARDEAVQERKRALEAER 438
I++ A R + + +L++ + ++ + E + +EE A+ + +++ +++EAE
Sbjct: 1625 HIDS--ANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEM 1682
Query: 439 QARVEEL-LMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQ 497
EEL +R +++A+ E+ E A A + + RL A A +E +EE Q
Sbjct: 1683 IQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ 1742
Query: 498 KKIQLKHDESIRRHMEQIEQ 517
+L +D +++ QI+Q
Sbjct: 1743 GNTELINDR-LKKANLQIDQ 1761
Score = 53.9 bits (128), Expect = 9e-07
Identities = 71/353 (20%), Positives = 143/353 (40%), Gaps = 36/353 (10%)
Query: 148 NEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTRE 207
N+ + A K + + D + + A +EE+ + K NE+ + S AE QL E
Sbjct: 1630 NKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA-KENEKKLKSMEAEMIQLQEE 1688
Query: 208 IEAEENNDINIETDNDS---DFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWG 264
+ A E + + D + + S G G++ A E R+ +
Sbjct: 1689 LAAAERAKRQAQQERDELADEIANSSGKGAL-----------------ALEEKRRLEARI 1731
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRK----RTIAESKKKHEEKQMKAQQLREKLREEKT 320
+EEE G+ ++++L + + T ++ H +K A+Q E+ +E
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791
Query: 321 LKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEI 380
+KLQ++ K K L+ + +EE+L + +R QA K+ + E K+ ++
Sbjct: 1792 VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER----QAACKQVRRTEKKLKDV 1847
Query: 381 AF------INTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRAL 434
N + +++ ++LK+ +++L E +EE QR ++ +++
Sbjct: 1848 LLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETA 1907
Query: 435 EAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTA 487
+A + V L K + + R+ K D + E + + A A
Sbjct: 1908 DAMNR-EVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPA 1959
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 78.2 bits (191), Expect = 4e-14
Identities = 101/472 (21%), Positives = 207/472 (43%), Gaps = 77/472 (16%)
Query: 293 TIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKL 352
T+ E +K +++ K++ R++L E+ +Q+ + + V+ E LLD R ++L
Sbjct: 852 TMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERC--DQL 909
Query: 353 LHAEFKREVQLQAIVKKAQEEEAKVNEIAF---------------INTLE-----AQNKR 392
+ A+F+ E +++ + ++A++EE E+ I+ LE + ++
Sbjct: 910 IKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEK 969
Query: 393 HDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQA--RVEELLMKRK 450
H +K+K + L+ L E + EK+A EA Q+ L+AE + + K +
Sbjct: 970 HATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLE 1029
Query: 451 EQEARIEQQRQEKEKAREDAARERARDR------EERLAALTAAQQEAMEELQKK----- 499
+Q +E ++++K R D R + + +E + L +Q+ E L+KK
Sbjct: 1030 QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYC 1089
Query: 500 -----------IQLKHDESIRRHMEQIEQRKE----KAAELSSGRHANTDYAPKLTPYER 544
+ L+ + I+ +IE+ +E + A + +DYA +L E
Sbjct: 1090 QLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE--EL 1147
Query: 545 KKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVV 604
++ + S+++ L ++ + ++ ++ L E + KK+
Sbjct: 1148 SERLEEAGGVTSTQIEL----NKKREAEFLKLRRDLEEATLQHEAMVAALRKKH------ 1197
Query: 605 ESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAK 664
+ + AE + + Q+ K+K +K K+ + S ME S S KA L+++ +
Sbjct: 1198 -ADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSME-----SVSKSKANLEKICR 1251
Query: 665 DLLKQV--------QVQDSGSWANNKVSALDRTLGEITRIL-EKENVADQIA 707
L Q+ ++Q S S + S L GE++R L EKE++ Q++
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLS 1303
Score = 67.8 bits (164), Expect = 6e-11
Identities = 147/784 (18%), Positives = 308/784 (39%), Gaps = 121/784 (15%)
Query: 2 KTKYIFCNITERKDAE---GWETVQRGRPIRSRSTAVMPKVSLATEATRSKDDSDKENVC 58
K + +C + + + E G + ++ + +++R + ++ A ATR+K + + +
Sbjct: 1083 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIE-AERATRAKTEKQRSDYA 1141
Query: 59 LLPDESIQKGQFVGDGTSNTIESHPKDSLHSCDHPLAEKTQFTVSTLDDVKNSGSIRDNY 118
+E ++ + G TS IE + K L + +TL ++R +
Sbjct: 1142 RELEELSERLEEAGGVTSTQIELNKKREAEF----LKLRRDLEEATLQHEAMVAALRKKH 1197
Query: 119 VRTSEISAVHIDTECVSVMLQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAK 178
+ ID LQ ++K EK+ + E+D D+S+SM V
Sbjct: 1198 ADSVAELGEQIDN-------------LQRVKQKLEKEKSEFKLEID--DLSSSMESVSKS 1242
Query: 179 KEELADRLEKANEEAIASAIAEEEQLTREIEA---------EENNDINIETDNDSDFSAS 229
K L +++ + E+ ++ A + E++ R + E +++ + + +
Sbjct: 1243 KANL-EKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQ 1301
Query: 230 MGSGSVSFCGMSMDWNDVLADYE--------ARESWRQNTSWGDIVEEEPARPPGHGIHM 281
+ +F + + L + A +S R + D++ E+ +
Sbjct: 1302 LSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDC---DLLREQYEEEQEGKAEL 1358
Query: 282 HEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVR------- 334
LS + + +A+ + K+E A Q E+L E K Q+L + E+ V
Sbjct: 1359 QRALSKANSE--VAQWRTKYETD---AIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCA 1413
Query: 335 ---KWKEEL--------------------LDQRRRMMEEKLLHAEFKRE---VQLQAIVK 368
K K+ L LD+++R ++ L + K E +L+A +K
Sbjct: 1414 SLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLK 1473
Query: 369 KAQE--------EEAKVNEIAFINTLEAQNKR-----HDVLSKLKEYEQRLNELQEERQR 415
+++ + A + + T++ +NK D+ ++ E + ++EL++ R++
Sbjct: 1474 ESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ 1533
Query: 416 RQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERA 475
+ EK A++E + ALE E +A++ + ++ + ++ I+++ EK++ E R
Sbjct: 1534 IELEKADIQLALEEAEAALEHE-EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQ 1592
Query: 476 RDREERLAALTAAQQEAMEELQKK-----------IQLKHDE----SIRRHMEQIE-QRK 519
R E +AL A + E ++ K IQL H +H+ ++ Q K
Sbjct: 1593 RTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK 1652
Query: 520 EKAAELSSGRHANTDYAPKLTPYERKKQCSLCNV-LISSEVYLFSHVKGRKHQQAVRENT 578
+ L D +L ER+ V + + + + Q+ + N
Sbjct: 1653 DTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNE 1712
Query: 579 SIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAK 638
+Q + + H + KK D++ + +A +D ++ KKA A M K
Sbjct: 1713 RVQLLHTQNTSLIH-TKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELK 1771
Query: 639 EYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSWANNK--VSALDRTLGEITRI 696
+ E S K L++ KDL ++ + + K + L+ + E+
Sbjct: 1772 K-----EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFE 1826
Query: 697 LEKE 700
LE E
Sbjct: 1827 LEGE 1830
Score = 44.7 bits (104), Expect = 5e-04
Identities = 80/349 (22%), Positives = 147/349 (42%), Gaps = 46/349 (13%)
Query: 386 LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEEL 445
L++ ++ + +E+++ +EL + +R+E ++ VQE K L+ + QA E L
Sbjct: 841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQE-KNDLQLQVQAESENL 899
Query: 446 LMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHD 505
L + + I+ + Q + K +E ERA D EE A LTA +++ +E +LK D
Sbjct: 900 LDAEERCDQLIKAKFQLEAKIKE--VTERAEDEEEINAELTAKKRKLEDECS---ELKKD 954
Query: 506 -ESIRRHMEQIEQRK----EKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVL-----I 555
+ + + ++E+ K K L+ + KLT ++ Q + L
Sbjct: 955 IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE 1014
Query: 556 SSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLK---------KYIIDIVVES 606
+V + K + QQ +S++ + ++E K + I+D+ +
Sbjct: 1015 EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Query: 607 TAPAEALKDG-----------EERQ----KNKKKAKKIKARMNFRAKEYESLMET--KNS 649
E LK E+ Q + +KK K+++AR+ +E E+ T K
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 650 GSDSPYKAKLQRLAKDLLKQVQVQDSGSWANNKVSA----LDRTLGEIT 694
S Y +L+ L++ L + V + N K A L R L E T
Sbjct: 1135 KQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEAT 1183
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 77.8 bits (190), Expect = 6e-14
Identities = 121/565 (21%), Positives = 249/565 (44%), Gaps = 66/565 (11%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLT 205
Q+ +E+ +A ++ D +++ + + K+E LA R EK ++EA A + ++L
Sbjct: 1608 QLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLA-QKRKKLA 1666
Query: 206 REIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLAD-YEARESWRQNTSWG 264
++ E + + + A G G + ++LA E QN W
Sbjct: 1667 KKWE---------KVAREEEKLAKKG-------GKLAEVKNILAQKVEELPQREQNLDWQ 1710
Query: 265 D---IVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTL 321
+ E E + E+ + + + E KK EE++ A Q REKL EE+T
Sbjct: 1711 EKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQ-REKLSEEET- 1768
Query: 322 KLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIA 381
KL + E+ + + KE+L + +M EE+ KRE ++ +K AQ+ E
Sbjct: 1769 ---KLAQEEELLIQEKEKLAQHKEKMPEEEERLGR-KREQLIEKKMKLAQKRE------R 1818
Query: 382 FINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ----ARDEAVQERKRALEAE 437
+IN++E K +L + K Q L +E+++ + K+ ++ +K+ ++ +
Sbjct: 1819 WINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVK 1878
Query: 438 RQ--------ARVEELLMKRKEQEARIEQQRQEKEK----AREDAARERARDREERL-AA 484
+ A+VEE L + KE + +++ E EK + A+++ + +E++ A
Sbjct: 1879 NKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVEDSLAKKQEKLAQEKMKLA 1938
Query: 485 LTAAQQEAMEELQKKIQL-KHDESIRRHMEQIEQRKEKAAE----LSSGRHANTDYAPKL 539
L A + + L+ ++ + K ++++ M+++ + K + E LS G T K+
Sbjct: 1939 LEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKM 1998
Query: 540 TPYER---KKQCSLCNVLISSEVYLF----SHVKGRKHQQAVRENTSIQG-RELSDEEVE 591
T E+ +++ SL ++ E + S + K + + +QG R+L+ +
Sbjct: 1999 TQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRK 2058
Query: 592 HLSLKKYIIDIVVESTAPAEALK--DGEERQKNKKKAKKIKARMNFRAKEYE-SLMETKN 648
+ ++ + + +AL+ +ER+ +++ K K + KE S+ ++K
Sbjct: 2059 LIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKL 2118
Query: 649 SGSDSPYKAKLQRLAKDLLKQVQVQ 673
+ + K L KD K + Q
Sbjct: 2119 DIKEWDFSEKRSELTKDEKKLARKQ 2143
Score = 71.2 bits (173), Expect = 5e-12
Identities = 99/461 (21%), Positives = 205/461 (44%), Gaps = 76/461 (16%)
Query: 281 MHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ--KLLEREKDVRK--- 335
+H K + +KR E K EE+++ AQ+ R+ +EE+ L K+ + ++++ +
Sbjct: 1577 IHRKRARAEKKRAQEERKLAQEEEKL-AQEERQLAQEERKLAQAYVKITQDDREMAQAEG 1635
Query: 336 ---WKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEE---------AKVNEIAFI 383
KEE L QR + ++ KR+ + K A+EEE A+V I
Sbjct: 1636 KFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQ 1695
Query: 384 NTLEAQNKRHDVLSKLKEYEQRLNELQ---EERQRRQEE-KQARDEAVQERKRALEAE-- 437
E + ++ + KE Q L EL+ EE ++EE Q + V+E+K+ E E
Sbjct: 1696 KVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEA 1755
Query: 438 -------------RQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAA 484
+ A+ EELL++ KE+ A+ +++ E+E+ R RE+ +++ +LA
Sbjct: 1756 LAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEE-RLGRKREQLIEKKMKLAQ 1814
Query: 485 LTAAQQEAMEEL--------QKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYA 536
+MEEL QKK + +++ + E++ QRKE N Y
Sbjct: 1815 KRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQRKE-----------NLLYN 1863
Query: 537 PKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLK 596
+ + +K+ V + +++ +F+ + + ++ +E ++ ++ E E K
Sbjct: 1864 KERLTHSKKQL-----VQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETE----K 1914
Query: 597 KYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYK 656
K + VE + + K +E+ K + ++ + R E + +
Sbjct: 1915 KL---VQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRG-------ELDIAKEEKALN 1964
Query: 657 AKLQRLAKDLLKQVQVQDSGSWANNKVSALDRTLGEITRIL 697
+++RLA++ ++ V+ +++ S ++ R + ++ + L
Sbjct: 1965 LEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQEL 2005
Score = 64.3 bits (155), Expect = 6e-10
Identities = 99/478 (20%), Positives = 202/478 (42%), Gaps = 60/478 (12%)
Query: 275 PGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQL----REKLREEKTL--KLQKLLE 328
PG+ + M +++S K+T +S K+ + K +++ RE +EE+ + +++++
Sbjct: 1378 PGN-VTMGKEISKKEEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMAT 1436
Query: 329 REKDVRKWKEELL---------DQRRRMMEEKLLHAEFKREVQL--QAIVKKAQEEEAKV 377
E+ V K + +L+ D ++ E K +H E ++ + + K+ +EE K+
Sbjct: 1437 LEEKVVKQEGKLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWEKRLLQEEEKL 1496
Query: 378 NEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQER--KRALE 435
++ + E + + D K +E++Q + + + Q+ K + ++E + E
Sbjct: 1497 HQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEE 1556
Query: 436 AERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEE 495
E+Q E+ ++ + + ARI ++R EK R R+ A++ E+ QE +
Sbjct: 1557 KEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKL 1616
Query: 496 LQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLI 555
Q +++ D+ R M Q E + + E + R + +RKK +
Sbjct: 1617 AQAYVKITQDD---REMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVA 1673
Query: 556 SSEVYL------FSHVKGRKHQQAV-----RENTSIQGRELSDE------EVEHLSLKKY 598
E L + VK Q+ +N Q +EL+ E ++E LS K+
Sbjct: 1674 REEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEE 1733
Query: 599 IIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYK-- 656
++ E E K EE + + +K+ A+E E L++ K + K
Sbjct: 1734 ELN-QEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMP 1792
Query: 657 ---AKLQRLAKDLL--KQVQVQDSGSWANNKVSALDRTLGEITR----ILEKENVADQ 705
+L R + L+ K Q W N ++ E+T+ + +K+N+A +
Sbjct: 1793 EEEERLGRKREQLIEKKMKLAQKRERWIN--------SMEELTKNKMILYQKKNLAQE 1842
Score = 61.2 bits (147), Expect = 5e-09
Identities = 54/237 (22%), Positives = 119/237 (50%), Gaps = 18/237 (7%)
Query: 289 SRKRT-IAESKKKHEEKQMK-AQQLREKLREEKTLKLQKLLERE-KDVRKWKEELLDQRR 345
S KR+ + + +KK KQ K A ++R + +E +K+ E E K RK E +LD
Sbjct: 2126 SEKRSELTKDEKKLARKQRKLANKMRRMINKE-----EKMTEEESKLARKHSEVILDDEE 2180
Query: 346 RM-MEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQ 404
+EE+ + KR + + K+ + + K + E +++ H +E E
Sbjct: 2181 EGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSS----QVDEVESEEHFS----EEMES 2232
Query: 405 RLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKE 464
L+EL+++ EE++ R+E + + + E + R EE + K+ E E+++++K+
Sbjct: 2233 LLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKK 2292
Query: 465 KAREDAARERARDREERLAALTAAQQEAM-EELQKKIQLKHDESIRRHMEQIEQRKE 520
+ +++ +E+ EE+ ++ + E++ +E +++ +E + R E +++ K+
Sbjct: 2293 EKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQ 2349
Score = 60.8 bits (146), Expect = 7e-09
Identities = 68/307 (22%), Positives = 145/307 (47%), Gaps = 23/307 (7%)
Query: 284 KLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEK-TLKLQKLLEREKDVRKWKEELL- 341
K+ +K T E K EE +M + ++E + +++ KL +E D + + EL
Sbjct: 2075 KILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTK 2134
Query: 342 DQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKV----NEIAFINTLEAQNKRHDVLS 397
D+++ +++ L + +R + + +K EEE+K+ +E+ + E + +V+
Sbjct: 2135 DEKKLARKQRKLANKMRRMINKE---EKMTEEESKLARKHSEVILDDEEEGGIEEEEVIP 2191
Query: 398 KLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIE 457
LK ++ E + + +++ DE E + E ++ ++EL K++ + E
Sbjct: 2192 FLKRRWRKRKEAKRGDKPKEKFSSQVDEV--ESEEHFSEEMESLLDEL-EKQESLSSEEE 2248
Query: 458 QQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQ 517
++R+E+E+ E+ RE +R+E ++ EE +KK + K E ++ E E+
Sbjct: 2249 EEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEE 2308
Query: 518 RKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVREN 577
++E +E + ++ + E ++ CSL + E + K K Q+ R+
Sbjct: 2309 KEEIMSEEETESLSDEE--------EEEESCSL-EEEVDREKEILKKEKQFKLQEQRRK- 2358
Query: 578 TSIQGRE 584
S++GRE
Sbjct: 2359 -SLRGRE 2364
Score = 60.1 bits (144), Expect = 1e-08
Identities = 93/390 (23%), Positives = 164/390 (42%), Gaps = 42/390 (10%)
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ 324
DI +EE A EK+ K T+++ + +Q K Q+ ++L E K +
Sbjct: 1955 DIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLEE 2014
Query: 325 KLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFIN 384
K+L E + +E + + + EF R Q I + Q + AK + I
Sbjct: 2015 KILLHEDRILAMEESEIAKGK---------LEFTRG---QRIFVQGQRKLAKASR-KLIK 2061
Query: 385 TLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEA-ERQARVE 443
E+ +K L+K+ + Q+L ++ER+ QEE + + + KRAL ER+ +E
Sbjct: 2062 KRESLSKEPAKLNKILKALQKLT--RDERKLTQEEIK-----MTKMKRALFVKERRLSIE 2114
Query: 444 ELLMKRKE---QEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKI 500
+ + KE E R E + EK+ AR+ + + ++ R+ ++E M E + K+
Sbjct: 2115 QSKLDIKEWDFSEKRSELTKDEKKLARK---QRKLANKMRRMIN----KEEKMTEEESKL 2167
Query: 501 QLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVY 560
KH E I E+ +E+ R A + + K + V SE +
Sbjct: 2168 ARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEV--ESEEH 2225
Query: 561 LFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQ 620
++ + +E+ S + E +EE E + V E + ++GEE+Q
Sbjct: 2226 FSEEMESLLDELEKQESLSSEEEEEREEEEEREE------EEVREEEEERKEEEEGEEKQ 2279
Query: 621 KNK---KKAKKIKARMNFRAKEYESLMETK 647
K +K KK K + +E E + E K
Sbjct: 2280 VEKEEEEKKKKKKEKKKEEVQEKEEVFEEK 2309
Score = 59.3 bits (142), Expect = 2e-08
Identities = 53/234 (22%), Positives = 114/234 (48%), Gaps = 11/234 (4%)
Query: 291 KRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQK----LLEREKDVRKWKEELLD-QRR 345
++ +A ++K K + EK+ EE++ +K +L+ E++ +EE++ +R
Sbjct: 2136 EKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKR 2195
Query: 346 RMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQR 405
R + K K + + + V + + EE E+ + L+ K+ + S+ +E +
Sbjct: 2196 RWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESL--LDELEKQESLSSEEEEEREE 2253
Query: 406 LNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEK 465
E +EE R +EE++ +E +E++ +E E + + ++ K+KE+ E+ +EKE+
Sbjct: 2254 EEEREEEEVREEEEERKEEEEGEEKQ--VEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEE 2311
Query: 466 AREDAARERARDREERLAALTAAQQEAMEE--LQKKIQLKHDESIRRHMEQIEQ 517
+ E D EE + + ++ E+ L+K+ Q K E R+ + E+
Sbjct: 2312 IMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRER 2365
Score = 42.4 bits (98), Expect = 0.003
Identities = 44/236 (18%), Positives = 112/236 (47%), Gaps = 28/236 (11%)
Query: 284 KLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDV----RKWKEE 339
KL++ R+ E K EE ++ + L +E+ + +E E+ + R+W++
Sbjct: 2145 KLANKMRRMINKEEKMTEEESKLARKHSEVILDDEE----EGGIEEEEVIPFLKRRWRKR 2200
Query: 340 LLDQRRRMMEEKL------LHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRH 393
+R +EK + +E ++++++ + +++E+ +E E + +R
Sbjct: 2201 KEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEE--EEREEEEERE 2258
Query: 394 DVLSKLKEYEQRLNELQEERQ--RRQEE-----KQARDEAVQERKRALEAERQARVEELL 446
+ + +E E++ E EE+Q + +EE K+ + E VQE++ E + EE++
Sbjct: 2259 EEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEK-----EEIM 2313
Query: 447 MKRKEQEARIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQL 502
+ + + E++ +E E+ RE+ ++E+ L +++++ ++ + +
Sbjct: 2314 SEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSI 2369
Score = 39.3 bits (90), Expect = 0.022
Identities = 87/437 (19%), Positives = 161/437 (36%), Gaps = 74/437 (16%)
Query: 149 EEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLE---KANEEAIASAIAEEEQLT 205
+EKF ++ +E+E S+ S+ + L K+E L+ E + EE + EEE+
Sbjct: 2210 KEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEER 2269
Query: 206 REIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD 265
+E E E + E + V + +V + E S + S D
Sbjct: 2270 KEEEEGEEKQVEKEEEEKKKKKKEKKKEEV------QEKEEVFEEKEEIMSEEETESLSD 2323
Query: 266 IVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREK-LR-EEKTLKL 323
EEE S + E + +EKQ K Q+ R K LR E+ L +
Sbjct: 2324 EEEEEE--------------SCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSI 2369
Query: 324 QKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEI--- 380
+ + K L +++M L E K + + K+ E+ K +
Sbjct: 2370 LRGVPHGKGRAIRLGVLKSPLKKLMSTAL---EMKEKTPVPVPEKQISWEDKKATVVEIP 2426
Query: 381 -AFINTLEAQNKRHDVLSKLKE---------YEQRLNELQEERQRRQEEKQARDEAVQER 430
F+ T++ K +V+ K + E + +L+ + E +Q +
Sbjct: 2427 RKFLGTMD---KEREVMGKYEPIPPHVLGTVLESQAQDLKTPFMSHILRRTVEAEELQHK 2483
Query: 431 KRA-----------LEAERQARVEELLMKRKEQEARIEQQRQEKEK---AREDAARERAR 476
L + + ++ + KEQ A + E + R +A + +R
Sbjct: 2484 PLGAWWKWFLQHPPLMGQTEVQLPLSQIPAKEQHADVSLSDVEWIRHVLERMEAGEQLSR 2543
Query: 477 DREERLAALTAAQQEAMEELQKKIQL------KHDESIRRHMEQIEQRKEKAAELSSGRH 530
D RL L +++L K L KH+ + RH + +E + + +SS +
Sbjct: 2544 DGFHRLCQL-------LKDLASKGNLEWLHLAKHEAIVYRHRQALESQDTR---ISSRQS 2593
Query: 531 ANTDYAPKLTPYERKKQ 547
+ Y + P + K++
Sbjct: 2594 MSPKYLKVIPPIKAKEK 2610
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 77.4 bits (189), Expect = 7e-14
Identities = 127/600 (21%), Positives = 249/600 (41%), Gaps = 49/600 (8%)
Query: 156 KARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENND 215
KA E + ++ E+ + EE RL +A E E R EAE +
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1581
Query: 216 INIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARP- 274
+ + S+ V+ + E E Q + + EE R
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLR----------EEAERRAQQQAEAERAREEAEREL 1631
Query: 275 ------PGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLE 328
+ + + ++++++A+++ + ++++ + + R EE+ ++ ++L E
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 329 REKDVRKWKEELLDQRRRMMEEKL--LHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
+E + ++ E Q+R E++L L AE ++ Q + ++ +EE A++ A
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL---EEELARLQREA----A 1744
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELL 446
A KR ++ ++L + + L + R +EE ++ E ++R LEAE R EL
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR---LEAEA-GRFRELA 1800
Query: 447 MKRKEQEARIEQQRQEKEKAREDAARERA---RDREERLAALTAAQQEAME-ELQKKIQL 502
+ A E+ +++++ A EDAAR+RA R E+LAA+ A + E E+ K +
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860
Query: 503 KHDESIRRHME----QIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSE 558
+E +RR E Q + +E+AA+ + K + E ++Q L +
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 559 VYLFSHVKGRK--HQQAVRENTSIQ---GRELSDEEVEHLSLKKYIIDIVVESTAPAE-- 611
+ + K ++A ++ GR S+ E S ++ ++ + AE
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 612 -ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQV 670
++ EER + A++ AR A E ++ K + + Q A+ L
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 671 QVQDSGSWANNKVS--ALDRTLGEITRILEKE-NVADQIAFQAAGGLTALEHILQAVVPA 727
+ A K A+ + E+ + L++E +V DQ+ +A A E +A V A
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Score = 76.3 bits (186), Expect = 2e-13
Identities = 86/362 (23%), Positives = 160/362 (44%), Gaps = 32/362 (8%)
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLL 353
E++ + + Q +A++LR ++++E K Q +E V+ E +++R + +EE L
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 354 HAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNE----- 408
AE QA V++A++ + + E Q+KR K + E+ L E
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 409 --LQEERQRR----QEEKQARDEAVQERKR----ALEAER-QARVEELLMKRKEQEARIE 457
L+EE +RR E ++AR+EA +E +R A EA R + + EE+ ++ +A E
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 458 QQRQEKEK-AREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+Q++E E+ AR E R+ LA +Q + E + +L ++ + R + E
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 517 QRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRE 576
Q +++ L A T ++ + L V EV L S + +
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE------- 1776
Query: 577 NTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFR 636
+ R S++ + L + + E A AL EE ++ ++ A++ AR
Sbjct: 1777 ----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAE 1830
Query: 637 AK 638
A+
Sbjct: 1831 AE 1832
Score = 73.2 bits (178), Expect = 1e-12
Identities = 117/531 (22%), Positives = 224/531 (42%), Gaps = 80/531 (15%)
Query: 107 DVKNSGSIRDNYVRTSEISAVHIDTE------CVSVMLQAGTPPLQVNEEKFPAEKARIE 160
+ + G + VR E++ ++ + L A +++ E E+ R
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 161 NEMDPSDISNSMAEVLAKKEELADRLEK--ANEEAIASAIAEEEQLTREIEAEENNDINI 218
E + + + A K++EL L K A E + ++ A E+ +R + +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 219 ETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHG 278
E + + A E+ RQ + EE+ AR
Sbjct: 1792 EAGRFRELAEEAARLRAL----------------AEEAKRQR----QLAEEDAARQRAEA 1831
Query: 279 IH-MHEKLSS---PSRKRTIAE-SKKKHEEKQMKAQQL-------REKLREEKTLKLQKL 326
+ EKL++ +R +T AE + K+ E + + ++L R +L E+ +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 327 LEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN------EI 380
ER +RK + L++++ ++E+ L +R+V+ + + KA E+A E+
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQ---RRQVEEEILALKASFEKAAAGKAELELEL 1948
Query: 381 AFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ-------ARDEAVQERKRA 433
I + R ++L+ QR +EER RR+E ++ A +EA ++RK A
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEER-RRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 434 LEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDR---EERLAALTAAQ 489
LE VE L K K +EAR ++R E+E AR+ A+E A+ R EE+ A Q
Sbjct: 2008 LE-----EVERL--KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 490 QEAMEELQKKIQLKHD---------ESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
+E +ELQ+ +Q + E+ RR E+ E+ + +A ++ + A +L
Sbjct: 2061 KE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 541 PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVE 591
++ + ++E L + ++A E +++ ++ +D E+E
Sbjct: 2119 QSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168
Score = 67.0 bits (162), Expect = 1e-10
Identities = 95/456 (20%), Positives = 186/456 (40%), Gaps = 65/456 (14%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEE--Q 203
QV +E E + + + + + A+ E A + + EE + + EE +
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242
Query: 204 LTREIEAEENNDINIETDNDSDF----SASMGSGSVSFCGMSMDWNDVLADYE-ARESWR 258
L IEAE I + DN F + M + +S+ + + A E
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 259 QNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAE--SKKKHEEKQMKAQQLREKLR 316
Q + + + +E + + + +++ +A+ +++ E+K+ AQQL E+
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE-- 2360
Query: 317 EEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQE---- 372
T Q+ LE E+ R+ + +R ++ ++ A+ + E Q K+A+E
Sbjct: 2361 ---TQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Query: 373 ----EEAKVNEIAFINTLEAQNKRHD-----VLSKLKEYEQRLNELQEER---QRRQEEK 420
E A ++ + TLE Q ++ D + + E E+ +LQ+E Q + EE
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 421 QA--------------------------RDEAVQERKRALEAERQARVEELLMKRKEQEA 454
Q R+ +++ K LE Q V + R+EQ+
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 455 RIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEEL------QKKIQLKHDESI 508
+QQ+ E+E+ R A+ E AR R+ +QE +++L Q+++ + ++ +
Sbjct: 2537 --QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYER 544
R ++ +E++ A S A+ A K P R
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2630
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/383 (22%), Positives = 162/383 (42%), Gaps = 52/383 (13%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEE--L 340
E ++SP++K + + ++ + LR E TL Q + + +R+ +EE L
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYV---DLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350
Query: 341 LDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLK 400
+Q+R E+L E E Q Q AQ + AQ +R + K
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAK--------------AQAER-----EAK 1391
Query: 401 EYEQRLNELQEERQRR----QEEKQARDEAVQERKRALEAE-----RQARVEELLMKRKE 451
E +QR+ E R+ Q++K++ E +Q+ +++ EAE RQA E R E
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 452 QEARI---EQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESI 508
+E R+ + + E+++ + + R R E A QE E L++++Q DES
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQ 1508
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAP----KLTPYERKKQCSLCNVLISSEVYLFSH 564
R+ ++E AE + R +L E +++ V + +V +
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1568
Query: 565 VKGRKHQQAVR-------ENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
R + ++ E T+ R L +E V L++ + + A AE ++
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-AERRAQQQAEAERAREEA 1627
Query: 618 ERQKNKKKAKKIKA-RMNFRAKE 639
ER+ + + K +A R+ +A+E
Sbjct: 1628 ERELERWQLKANEALRLRLQAEE 1650
Score = 61.2 bits (147), Expect = 5e-09
Identities = 142/650 (21%), Positives = 247/650 (38%), Gaps = 143/650 (22%)
Query: 145 LQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQL 204
L+ + EK A KA +E E+ I ++ + L KE+ LE A + +A AEEE+
Sbjct: 1930 LKASFEKAAAGKAELELEL--GRIRSNAEDTLRSKEQA--ELEAARQRQLA---AEEERR 1982
Query: 205 TREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWG 264
RE E + E + A++ + + A E R+
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALE-----------EVERLKAKVEEARRLRERA--- 2028
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ 324
E+E AR + ++KR AE K Q K Q+L++ L++E+++ Q
Sbjct: 2029 ---EQESAR-------QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 325 ---------KLLEREKDVRKWKEELLDQRRRMMEEK-----------------LLHAEFK 358
+ E ++ R E Q RR +EE AE
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138
Query: 359 REVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKR--HDVLSKLKEYEQRLNELQEERQRR 416
R+ Q ++AQ E+A + + + ++K+ L + + EQ L L+ + +
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 417 QEEKQARDEAVQERK-RALEAERQ----------------------ARVEE----LLMKR 449
+K DE +Q K A EA RQ AR+E L+++
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Query: 450 KEQEARIEQQRQEKEK----------------------AREDAARERARD----REERLA 483
K+ R Q+ EK K A ED A++RA +E+ A
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 484 ALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYE 543
A + +A EL ++ + E RR E EQ ++ AE + G + E
Sbjct: 2319 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE-------AE 2371
Query: 544 RKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
R++Q + + L V QA E + + R+ ++E E L +
Sbjct: 2372 RQRQLEMS----AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLA 663
V E +RQ++ A++++ + +E E L + +AKL +L
Sbjct: 2428 VTLVQTLEI-----QRQQSDHDAERLREAIAELEREKEKLQQ----------EAKLLQLK 2472
Query: 664 KDLLKQVQ----VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQ 709
+ ++ VQ +Q++ + + +S D L + R +E+E + FQ
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQ 2521
Score = 61.2 bits (147), Expect = 5e-09
Identities = 79/349 (22%), Positives = 160/349 (45%), Gaps = 45/349 (12%)
Query: 173 AEVLAKKEELAD---RLEKANEEAIASAIAEEEQ-LTREIEAEENNDINIETDNDSDFSA 228
AE+L +++ELA R + ++E +A +AEE Q R +EAE + + + +
Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER---- 2384
Query: 229 SMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD-------IVEEEPARPPGHGIHM 281
+ M A+ +A+ +Q G+ +E+ I
Sbjct: 2385 ------LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2438
Query: 282 HEKLSSPSRKR-TIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKW---- 336
+ R R IAE +++ E+ Q +A+ L+ K E +T++ ++LL+ + +++
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Query: 337 KEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ---EEEAKVNEIAFINTLEAQNKRH 393
K+ LL + R + +EK K E Q V KAQ EE+ + + + + +R
Sbjct: 2499 KDSLLQRERFIEQEKA-----KLEQLFQDEVAKAQQLREEQQRQQQ-------QMEQERQ 2546
Query: 394 DVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQE 453
+++ ++E +R +E +E +R+QEE Q ++ ++++ L E Q E+L + E++
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL--LEEQ 2604
Query: 454 ARIEQQRQEKEKAREDAARERARDREERL--AALTAAQQEAMEELQKKI 500
R E+ A + AA + + + L A A + + + L++K+
Sbjct: 2605 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 47/370 (12%)
Query: 315 LREEKTLKLQKLLEREKDVRKWKEEL----LDQRRRMMEEKLLHAEFKREVQLQAIVKKA 370
LR E L L KL + + E+L L R E++L A ++ + QA+
Sbjct: 1063 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122
Query: 371 QEEEAKVNEIAFINT-LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQE 429
E EA + + EAQ D L ++ + E+ E Q+R E+ E +E
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDAL---RDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 430 RKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDREERLAALTAA 488
R L QA + + ++++E E Q R +E A A + AR R+E++ A+ A
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239
Query: 489 QQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQ- 547
+A+ E ++ Q +E I RH E++E+ + A + +A DY +L Y+ + +
Sbjct: 1240 DSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYI---NAIKDYELQLVTYKAQLEP 1295
Query: 548 ----CSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
V SE + +V R H + TS +YI I
Sbjct: 1296 VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----------------QYIKFI- 1337
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ--R 661
+E L+ EE + + A++ +A R E E+ +E + +++ +AK Q R
Sbjct: 1338 ------SETLRRMEEEE---RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 662 LAKDLLKQVQ 671
AK+L +++Q
Sbjct: 1389 EAKELQQRMQ 1398
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 77.4 bits (189), Expect = 7e-14
Identities = 127/600 (21%), Positives = 249/600 (41%), Gaps = 49/600 (8%)
Query: 156 KARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENND 215
KA E + ++ E+ + EE RL +A E E R EAE +
Sbjct: 1526 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1585
Query: 216 INIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARP- 274
+ + S+ V+ + E E Q + + EE R
Sbjct: 1586 RASFAEKTAQLERSLQEEHVAVAQLR----------EEAERRAQQQAEAERAREEAEREL 1635
Query: 275 ------PGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLE 328
+ + + ++++++A+++ + ++++ + + R EE+ ++ ++L E
Sbjct: 1636 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1695
Query: 329 REKDVRKWKEELLDQRRRMMEEKL--LHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
+E + ++ E Q+R E++L L AE ++ Q + ++ +EE A++ A
Sbjct: 1696 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL---EEELARLQREA----A 1748
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELL 446
A KR ++ ++L + + L + R +EE ++ E ++R LEAE R EL
Sbjct: 1749 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR---LEAEA-GRFRELA 1804
Query: 447 MKRKEQEARIEQQRQEKEKAREDAARERA---RDREERLAALTAAQQEAME-ELQKKIQL 502
+ A E+ +++++ A EDAAR+RA R E+LAA+ A + E E+ K +
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1864
Query: 503 KHDESIRRHME----QIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSE 558
+E +RR E Q + +E+AA+ + K + E ++Q L +
Sbjct: 1865 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924
Query: 559 VYLFSHVKGRK--HQQAVRENTSIQ---GRELSDEEVEHLSLKKYIIDIVVESTAPAE-- 611
+ + K ++A ++ GR S+ E S ++ ++ + AE
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984
Query: 612 -ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQV 670
++ EER + A++ AR A E ++ K + + Q A+ L
Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044
Query: 671 QVQDSGSWANNKVS--ALDRTLGEITRILEKE-NVADQIAFQAAGGLTALEHILQAVVPA 727
+ A K A+ + E+ + L++E +V DQ+ +A A E +A V A
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2104
Score = 76.3 bits (186), Expect = 2e-13
Identities = 86/362 (23%), Positives = 160/362 (44%), Gaps = 32/362 (8%)
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLL 353
E++ + + Q +A++LR ++++E K Q +E V+ E +++R + +EE L
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547
Query: 354 HAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNE----- 408
AE QA V++A++ + + E Q+KR K + E+ L E
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1607
Query: 409 --LQEERQRR----QEEKQARDEAVQERKR----ALEAER-QARVEELLMKRKEQEARIE 457
L+EE +RR E ++AR+EA +E +R A EA R + + EE+ ++ +A E
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667
Query: 458 QQRQEKEK-AREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+Q++E E+ AR E R+ LA +Q + E + +L ++ + R + E
Sbjct: 1668 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727
Query: 517 QRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRE 576
Q +++ L A T ++ + L V EV L S + +
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE------- 1780
Query: 577 NTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFR 636
+ R S++ + L + + E A AL EE ++ ++ A++ AR
Sbjct: 1781 ----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAE 1834
Query: 637 AK 638
A+
Sbjct: 1835 AE 1836
Score = 73.2 bits (178), Expect = 1e-12
Identities = 117/531 (22%), Positives = 224/531 (42%), Gaps = 80/531 (15%)
Query: 107 DVKNSGSIRDNYVRTSEISAVHIDTE------CVSVMLQAGTPPLQVNEEKFPAEKARIE 160
+ + G + VR E++ ++ + L A +++ E E+ R
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1735
Query: 161 NEMDPSDISNSMAEVLAKKEELADRLEK--ANEEAIASAIAEEEQLTREIEAEENNDINI 218
E + + + A K++EL L K A E + ++ A E+ +R + +
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Query: 219 ETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHG 278
E + + A E+ RQ + EE+ AR
Sbjct: 1796 EAGRFRELAEEAARLRAL----------------AEEAKRQR----QLAEEDAARQRAEA 1835
Query: 279 IH-MHEKLSS---PSRKRTIAE-SKKKHEEKQMKAQQL-------REKLREEKTLKLQKL 326
+ EKL++ +R +T AE + K+ E + + ++L R +L E+ +
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895
Query: 327 LEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN------EI 380
ER +RK + L++++ ++E+ L +R+V+ + + KA E+A E+
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQ---RRQVEEEILALKASFEKAAAGKAELELEL 1952
Query: 381 AFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ-------ARDEAVQERKRA 433
I + R ++L+ QR +EER RR+E ++ A +EA ++RK A
Sbjct: 1953 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEER-RRREAEERVQKSLAAEEEAARQRKAA 2011
Query: 434 LEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDR---EERLAALTAAQ 489
LE VE L K K +EAR ++R E+E AR+ A+E A+ R EE+ A Q
Sbjct: 2012 LE-----EVERL--KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064
Query: 490 QEAMEELQKKIQLKHD---------ESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
+E +ELQ+ +Q + E+ RR E+ E+ + +A ++ + A +L
Sbjct: 2065 KE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2122
Query: 541 PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVE 591
++ + ++E L + ++A E +++ ++ +D E+E
Sbjct: 2123 QSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEME 2172
Score = 67.0 bits (162), Expect = 1e-10
Identities = 95/456 (20%), Positives = 186/456 (40%), Gaps = 65/456 (14%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEE--Q 203
QV +E E + + + + + A+ E A + + EE + + EE +
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2246
Query: 204 LTREIEAEENNDINIETDNDSDF----SASMGSGSVSFCGMSMDWNDVLADYE-ARESWR 258
L IEAE I + DN F + M + +S+ + + A E
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2306
Query: 259 QNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAE--SKKKHEEKQMKAQQLREKLR 316
Q + + + +E + + + +++ +A+ +++ E+K+ AQQL E+
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE-- 2364
Query: 317 EEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQE---- 372
T Q+ LE E+ R+ + +R ++ ++ A+ + E Q K+A+E
Sbjct: 2365 ---TQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2420
Query: 373 ----EEAKVNEIAFINTLEAQNKRHD-----VLSKLKEYEQRLNELQEER---QRRQEEK 420
E A ++ + TLE Q ++ D + + E E+ +LQ+E Q + EE
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480
Query: 421 QA--------------------------RDEAVQERKRALEAERQARVEELLMKRKEQEA 454
Q R+ +++ K LE Q V + R+EQ+
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540
Query: 455 RIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEEL------QKKIQLKHDESI 508
+QQ+ E+E+ R A+ E AR R+ +QE +++L Q+++ + ++ +
Sbjct: 2541 --QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2598
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYER 544
R ++ +E++ A S A+ A K P R
Sbjct: 2599 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2634
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/383 (22%), Positives = 162/383 (42%), Gaps = 52/383 (13%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEE--L 340
E ++SP++K + + ++ + LR E TL Q + + +R+ +EE L
Sbjct: 1298 EPVASPAKKPKVQSGSESVIQEYV---DLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1354
Query: 341 LDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLK 400
+Q+R E+L E E Q Q AQ + AQ +R + K
Sbjct: 1355 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAK--------------AQAER-----EAK 1395
Query: 401 EYEQRLNELQEERQRR----QEEKQARDEAVQERKRALEAE-----RQARVEELLMKRKE 451
E +QR+ E R+ Q++K++ E +Q+ +++ EAE RQA E R E
Sbjct: 1396 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1455
Query: 452 QEARI---EQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESI 508
+E R+ + + E+++ + + R R E A QE E L++++Q DES
Sbjct: 1456 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQ 1512
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAP----KLTPYERKKQCSLCNVLISSEVYLFSH 564
R+ ++E AE + R +L E +++ V + +V +
Sbjct: 1513 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1572
Query: 565 VKGRKHQQAVR-------ENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
R + ++ E T+ R L +E V L++ + + A AE ++
Sbjct: 1573 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-AERRAQQQAEAERAREEA 1631
Query: 618 ERQKNKKKAKKIKA-RMNFRAKE 639
ER+ + + K +A R+ +A+E
Sbjct: 1632 ERELERWQLKANEALRLRLQAEE 1654
Score = 61.2 bits (147), Expect = 5e-09
Identities = 142/650 (21%), Positives = 247/650 (38%), Gaps = 143/650 (22%)
Query: 145 LQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQL 204
L+ + EK A KA +E E+ I ++ + L KE+ LE A + +A AEEE+
Sbjct: 1934 LKASFEKAAAGKAELELEL--GRIRSNAEDTLRSKEQA--ELEAARQRQLA---AEEERR 1986
Query: 205 TREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWG 264
RE E + E + A++ + + A E R+
Sbjct: 1987 RREAEERVQKSLAAEEEAARQRKAALE-----------EVERLKAKVEEARRLRERA--- 2032
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ 324
E+E AR + ++KR AE K Q K Q+L++ L++E+++ Q
Sbjct: 2033 ---EQESAR-------QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082
Query: 325 ---------KLLEREKDVRKWKEELLDQRRRMMEEK-----------------LLHAEFK 358
+ E ++ R E Q RR +EE AE
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2142
Query: 359 REVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKR--HDVLSKLKEYEQRLNELQEERQRR 416
R+ Q ++AQ E+A + + + ++K+ L + + EQ L L+ + +
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202
Query: 417 QEEKQARDEAVQERK-RALEAERQ----------------------ARVEE----LLMKR 449
+K DE +Q K A EA RQ AR+E L+++
Sbjct: 2203 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2262
Query: 450 KEQEARIEQQRQEKEK----------------------AREDAARERARD----REERLA 483
K+ R Q+ EK K A ED A++RA +E+ A
Sbjct: 2263 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2322
Query: 484 ALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYE 543
A + +A EL ++ + E RR E EQ ++ AE + G + E
Sbjct: 2323 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE-------AE 2375
Query: 544 RKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
R++Q + + L V QA E + + R+ ++E E L +
Sbjct: 2376 RQRQLEMS----AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2431
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLA 663
V E +RQ++ A++++ + +E E L + +AKL +L
Sbjct: 2432 VTLVQTLEI-----QRQQSDHDAERLREAIAELEREKEKLQQ----------EAKLLQLK 2476
Query: 664 KDLLKQVQ----VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQ 709
+ ++ VQ +Q++ + + +S D L + R +E+E + FQ
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQ 2525
Score = 61.2 bits (147), Expect = 5e-09
Identities = 79/349 (22%), Positives = 160/349 (45%), Gaps = 45/349 (12%)
Query: 173 AEVLAKKEELAD---RLEKANEEAIASAIAEEEQ-LTREIEAEENNDINIETDNDSDFSA 228
AE+L +++ELA R + ++E +A +AEE Q R +EAE + + + +
Sbjct: 2333 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER---- 2388
Query: 229 SMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD-------IVEEEPARPPGHGIHM 281
+ M A+ +A+ +Q G+ +E+ I
Sbjct: 2389 ------LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2442
Query: 282 HEKLSSPSRKR-TIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKW---- 336
+ R R IAE +++ E+ Q +A+ L+ K E +T++ ++LL+ + +++
Sbjct: 2443 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2502
Query: 337 KEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ---EEEAKVNEIAFINTLEAQNKRH 393
K+ LL + R + +EK K E Q V KAQ EE+ + + + + +R
Sbjct: 2503 KDSLLQRERFIEQEKA-----KLEQLFQDEVAKAQQLREEQQRQQQ-------QMEQERQ 2550
Query: 394 DVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQE 453
+++ ++E +R +E +E +R+QEE Q ++ ++++ L E Q E+L + E++
Sbjct: 2551 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL--LEEQ 2608
Query: 454 ARIEQQRQEKEKAREDAARERARDREERL--AALTAAQQEAMEELQKKI 500
R E+ A + AA + + + L A A + + + L++K+
Sbjct: 2609 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2657
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 47/370 (12%)
Query: 315 LREEKTLKLQKLLEREKDVRKWKEEL----LDQRRRMMEEKLLHAEFKREVQLQAIVKKA 370
LR E L L KL + + E+L L R E++L A ++ + QA+
Sbjct: 1067 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1126
Query: 371 QEEEAKVNEIAFINT-LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQE 429
E EA + + EAQ D L ++ + E+ E Q+R E+ E +E
Sbjct: 1127 PELEATKASLKKLRAQAEAQQPTFDAL---RDELRGAQEVGERLQQRHGERDVEVERWRE 1183
Query: 430 RKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDREERLAALTAA 488
R L QA + + ++++E E Q R +E A A + AR R+E++ A+ A
Sbjct: 1184 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1243
Query: 489 QQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQ- 547
+A+ E ++ Q +E I RH E++E+ + A + +A DY +L Y+ + +
Sbjct: 1244 DSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYI---NAIKDYELQLVTYKAQLEP 1299
Query: 548 ----CSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
V SE + +V R H + TS +YI I
Sbjct: 1300 VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----------------QYIKFI- 1341
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ--R 661
+E L+ EE + + A++ +A R E E+ +E + +++ +AK Q R
Sbjct: 1342 ------SETLRRMEEEE---RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1392
Query: 662 LAKDLLKQVQ 671
AK+L +++Q
Sbjct: 1393 EAKELQQRMQ 1402
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 77.4 bits (189), Expect = 7e-14
Identities = 127/600 (21%), Positives = 249/600 (41%), Gaps = 49/600 (8%)
Query: 156 KARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENND 215
KA E + ++ E+ + EE RL +A E E R EAE +
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1581
Query: 216 INIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARP- 274
+ + S+ V+ + E E Q + + EE R
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLR----------EEAERRAQQQAEAERAREEAEREL 1631
Query: 275 ------PGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLE 328
+ + + ++++++A+++ + ++++ + + R EE+ ++ ++L E
Sbjct: 1632 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1691
Query: 329 REKDVRKWKEELLDQRRRMMEEKL--LHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
+E + ++ E Q+R E++L L AE ++ Q + ++ +EE A++ A
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL---EEELARLQREA----A 1744
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELL 446
A KR ++ ++L + + L + R +EE ++ E ++R LEAE R EL
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR---LEAEA-GRFRELA 1800
Query: 447 MKRKEQEARIEQQRQEKEKAREDAARERA---RDREERLAALTAAQQEAME-ELQKKIQL 502
+ A E+ +++++ A EDAAR+RA R E+LAA+ A + E E+ K +
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860
Query: 503 KHDESIRRHME----QIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSE 558
+E +RR E Q + +E+AA+ + K + E ++Q L +
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 559 VYLFSHVKGRK--HQQAVRENTSIQ---GRELSDEEVEHLSLKKYIIDIVVESTAPAE-- 611
+ + K ++A ++ GR S+ E S ++ ++ + AE
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 612 -ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQV 670
++ EER + A++ AR A E ++ K + + Q A+ L
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 671 QVQDSGSWANNKVS--ALDRTLGEITRILEKE-NVADQIAFQAAGGLTALEHILQAVVPA 727
+ A K A+ + E+ + L++E +V DQ+ +A A E +A V A
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Score = 76.3 bits (186), Expect = 2e-13
Identities = 86/362 (23%), Positives = 160/362 (44%), Gaps = 32/362 (8%)
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLL 353
E++ + + Q +A++LR ++++E K Q +E V+ E +++R + +EE L
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543
Query: 354 HAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNE----- 408
AE QA V++A++ + + E Q+KR K + E+ L E
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 409 --LQEERQRR----QEEKQARDEAVQERKR----ALEAER-QARVEELLMKRKEQEARIE 457
L+EE +RR E ++AR+EA +E +R A EA R + + EE+ ++ +A E
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 458 QQRQEKEK-AREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+Q++E E+ AR E R+ LA +Q + E + +L ++ + R + E
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 517 QRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRE 576
Q +++ L A T ++ + L V EV L S + +
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE------- 1776
Query: 577 NTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFR 636
+ R S++ + L + + E A AL EE ++ ++ A++ AR
Sbjct: 1777 ----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAE 1830
Query: 637 AK 638
A+
Sbjct: 1831 AE 1832
Score = 73.2 bits (178), Expect = 1e-12
Identities = 117/531 (22%), Positives = 224/531 (42%), Gaps = 80/531 (15%)
Query: 107 DVKNSGSIRDNYVRTSEISAVHIDTE------CVSVMLQAGTPPLQVNEEKFPAEKARIE 160
+ + G + VR E++ ++ + L A +++ E E+ R
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 161 NEMDPSDISNSMAEVLAKKEELADRLEK--ANEEAIASAIAEEEQLTREIEAEENNDINI 218
E + + + A K++EL L K A E + ++ A E+ +R + +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 219 ETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHG 278
E + + A E+ RQ + EE+ AR
Sbjct: 1792 EAGRFRELAEEAARLRAL----------------AEEAKRQR----QLAEEDAARQRAEA 1831
Query: 279 IH-MHEKLSS---PSRKRTIAE-SKKKHEEKQMKAQQL-------REKLREEKTLKLQKL 326
+ EKL++ +R +T AE + K+ E + + ++L R +L E+ +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 327 LEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN------EI 380
ER +RK + L++++ ++E+ L +R+V+ + + KA E+A E+
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQ---RRQVEEEILALKASFEKAAAGKAELELEL 1948
Query: 381 AFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ-------ARDEAVQERKRA 433
I + R ++L+ QR +EER RR+E ++ A +EA ++RK A
Sbjct: 1949 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEER-RRREAEERVQKSLAAEEEAARQRKAA 2007
Query: 434 LEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDR---EERLAALTAAQ 489
LE VE L K K +EAR ++R E+E AR+ A+E A+ R EE+ A Q
Sbjct: 2008 LE-----EVERL--KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 490 QEAMEELQKKIQLKHD---------ESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
+E +ELQ+ +Q + E+ RR E+ E+ + +A ++ + A +L
Sbjct: 2061 KE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2118
Query: 541 PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVE 591
++ + ++E L + ++A E +++ ++ +D E+E
Sbjct: 2119 QSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168
Score = 67.0 bits (162), Expect = 1e-10
Identities = 95/456 (20%), Positives = 186/456 (40%), Gaps = 65/456 (14%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEE--Q 203
QV +E E + + + + + A+ E A + + EE + + EE +
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242
Query: 204 LTREIEAEENNDINIETDNDSDF----SASMGSGSVSFCGMSMDWNDVLADYE-ARESWR 258
L IEAE I + DN F + M + +S+ + + A E
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 259 QNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAE--SKKKHEEKQMKAQQLREKLR 316
Q + + + +E + + + +++ +A+ +++ E+K+ AQQL E+
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE-- 2360
Query: 317 EEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQE---- 372
T Q+ LE E+ R+ + +R ++ ++ A+ + E Q K+A+E
Sbjct: 2361 ---TQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416
Query: 373 ----EEAKVNEIAFINTLEAQNKRHD-----VLSKLKEYEQRLNELQEER---QRRQEEK 420
E A ++ + TLE Q ++ D + + E E+ +LQ+E Q + EE
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476
Query: 421 QA--------------------------RDEAVQERKRALEAERQARVEELLMKRKEQEA 454
Q R+ +++ K LE Q V + R+EQ+
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536
Query: 455 RIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEEL------QKKIQLKHDESI 508
+QQ+ E+E+ R A+ E AR R+ +QE +++L Q+++ + ++ +
Sbjct: 2537 --QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYER 544
R ++ +E++ A S A+ A K P R
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2630
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/383 (22%), Positives = 162/383 (42%), Gaps = 52/383 (13%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEE--L 340
E ++SP++K + + ++ + LR E TL Q + + +R+ +EE L
Sbjct: 1294 EPVASPAKKPKVQSGSESVIQEYV---DLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350
Query: 341 LDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLK 400
+Q+R E+L E E Q Q AQ + AQ +R + K
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAK--------------AQAER-----EAK 1391
Query: 401 EYEQRLNELQEERQRR----QEEKQARDEAVQERKRALEAE-----RQARVEELLMKRKE 451
E +QR+ E R+ Q++K++ E +Q+ +++ EAE RQA E R E
Sbjct: 1392 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 452 QEARI---EQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESI 508
+E R+ + + E+++ + + R R E A QE E L++++Q DES
Sbjct: 1452 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQ 1508
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAP----KLTPYERKKQCSLCNVLISSEVYLFSH 564
R+ ++E AE + R +L E +++ V + +V +
Sbjct: 1509 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1568
Query: 565 VKGRKHQQAVR-------ENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
R + ++ E T+ R L +E V L++ + + A AE ++
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-AERRAQQQAEAERAREEA 1627
Query: 618 ERQKNKKKAKKIKA-RMNFRAKE 639
ER+ + + K +A R+ +A+E
Sbjct: 1628 ERELERWQLKANEALRLRLQAEE 1650
Score = 61.2 bits (147), Expect = 5e-09
Identities = 142/650 (21%), Positives = 247/650 (38%), Gaps = 143/650 (22%)
Query: 145 LQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQL 204
L+ + EK A KA +E E+ I ++ + L KE+ LE A + +A AEEE+
Sbjct: 1930 LKASFEKAAAGKAELELEL--GRIRSNAEDTLRSKEQA--ELEAARQRQLA---AEEERR 1982
Query: 205 TREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWG 264
RE E + E + A++ + + A E R+
Sbjct: 1983 RREAEERVQKSLAAEEEAARQRKAALE-----------EVERLKAKVEEARRLRERA--- 2028
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ 324
E+E AR + ++KR AE K Q K Q+L++ L++E+++ Q
Sbjct: 2029 ---EQESAR-------QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 325 ---------KLLEREKDVRKWKEELLDQRRRMMEEK-----------------LLHAEFK 358
+ E ++ R E Q RR +EE AE
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138
Query: 359 REVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKR--HDVLSKLKEYEQRLNELQEERQRR 416
R+ Q ++AQ E+A + + + ++K+ L + + EQ L L+ + +
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 417 QEEKQARDEAVQERK-RALEAERQ----------------------ARVEE----LLMKR 449
+K DE +Q K A EA RQ AR+E L+++
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Query: 450 KEQEARIEQQRQEKEK----------------------AREDAARERARD----REERLA 483
K+ R Q+ EK K A ED A++RA +E+ A
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 484 ALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYE 543
A + +A EL ++ + E RR E EQ ++ AE + G + E
Sbjct: 2319 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE-------AE 2371
Query: 544 RKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
R++Q + + L V QA E + + R+ ++E E L +
Sbjct: 2372 RQRQLEMS----AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2427
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLA 663
V E +RQ++ A++++ + +E E L + +AKL +L
Sbjct: 2428 VTLVQTLEI-----QRQQSDHDAERLREAIAELEREKEKLQQ----------EAKLLQLK 2472
Query: 664 KDLLKQVQ----VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQ 709
+ ++ VQ +Q++ + + +S D L + R +E+E + FQ
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQ 2521
Score = 61.2 bits (147), Expect = 5e-09
Identities = 79/349 (22%), Positives = 160/349 (45%), Gaps = 45/349 (12%)
Query: 173 AEVLAKKEELAD---RLEKANEEAIASAIAEEEQ-LTREIEAEENNDINIETDNDSDFSA 228
AE+L +++ELA R + ++E +A +AEE Q R +EAE + + + +
Sbjct: 2329 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER---- 2384
Query: 229 SMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD-------IVEEEPARPPGHGIHM 281
+ M A+ +A+ +Q G+ +E+ I
Sbjct: 2385 ------LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2438
Query: 282 HEKLSSPSRKR-TIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKW---- 336
+ R R IAE +++ E+ Q +A+ L+ K E +T++ ++LL+ + +++
Sbjct: 2439 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2498
Query: 337 KEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ---EEEAKVNEIAFINTLEAQNKRH 393
K+ LL + R + +EK K E Q V KAQ EE+ + + + + +R
Sbjct: 2499 KDSLLQRERFIEQEKA-----KLEQLFQDEVAKAQQLREEQQRQQQ-------QMEQERQ 2546
Query: 394 DVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQE 453
+++ ++E +R +E +E +R+QEE Q ++ ++++ L E Q E+L + E++
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL--LEEQ 2604
Query: 454 ARIEQQRQEKEKAREDAARERARDREERL--AALTAAQQEAMEELQKKI 500
R E+ A + AA + + + L A A + + + L++K+
Sbjct: 2605 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2653
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 47/370 (12%)
Query: 315 LREEKTLKLQKLLEREKDVRKWKEEL----LDQRRRMMEEKLLHAEFKREVQLQAIVKKA 370
LR E L L KL + + E+L L R E++L A ++ + QA+
Sbjct: 1063 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1122
Query: 371 QEEEAKVNEIAFINT-LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQE 429
E EA + + EAQ D L ++ + E+ E Q+R E+ E +E
Sbjct: 1123 PELEATKASLKKLRAQAEAQQPTFDAL---RDELRGAQEVGERLQQRHGERDVEVERWRE 1179
Query: 430 RKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDREERLAALTAA 488
R L QA + + ++++E E Q R +E A A + AR R+E++ A+ A
Sbjct: 1180 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1239
Query: 489 QQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQ- 547
+A+ E ++ Q +E I RH E++E+ + A + +A DY +L Y+ + +
Sbjct: 1240 DSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYI---NAIKDYELQLVTYKAQLEP 1295
Query: 548 ----CSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
V SE + +V R H + TS +YI I
Sbjct: 1296 VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----------------QYIKFI- 1337
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ--R 661
+E L+ EE + + A++ +A R E E+ +E + +++ +AK Q R
Sbjct: 1338 ------SETLRRMEEEE---RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 662 LAKDLLKQVQ 671
AK+L +++Q
Sbjct: 1389 EAKELQQRMQ 1398
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 77.4 bits (189), Expect = 7e-14
Identities = 127/600 (21%), Positives = 249/600 (41%), Gaps = 49/600 (8%)
Query: 156 KARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENND 215
KA E + ++ E+ + EE RL +A E E R EAE +
Sbjct: 1490 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1549
Query: 216 INIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARP- 274
+ + S+ V+ + E E Q + + EE R
Sbjct: 1550 RASFAEKTAQLERSLQEEHVAVAQLR----------EEAERRAQQQAEAERAREEAEREL 1599
Query: 275 ------PGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLE 328
+ + + ++++++A+++ + ++++ + + R EE+ ++ ++L E
Sbjct: 1600 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1659
Query: 329 REKDVRKWKEELLDQRRRMMEEKL--LHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
+E + ++ E Q+R E++L L AE ++ Q + ++ +EE A++ A
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL---EEELARLQREA----A 1712
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELL 446
A KR ++ ++L + + L + R +EE ++ E ++R LEAE R EL
Sbjct: 1713 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR---LEAEA-GRFRELA 1768
Query: 447 MKRKEQEARIEQQRQEKEKAREDAARERA---RDREERLAALTAAQQEAME-ELQKKIQL 502
+ A E+ +++++ A EDAAR+RA R E+LAA+ A + E E+ K +
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1828
Query: 503 KHDESIRRHME----QIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSE 558
+E +RR E Q + +E+AA+ + K + E ++Q L +
Sbjct: 1829 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888
Query: 559 VYLFSHVKGRK--HQQAVRENTSIQ---GRELSDEEVEHLSLKKYIIDIVVESTAPAE-- 611
+ + K ++A ++ GR S+ E S ++ ++ + AE
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948
Query: 612 -ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQV 670
++ EER + A++ AR A E ++ K + + Q A+ L
Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008
Query: 671 QVQDSGSWANNKVS--ALDRTLGEITRILEKE-NVADQIAFQAAGGLTALEHILQAVVPA 727
+ A K A+ + E+ + L++E +V DQ+ +A A E +A V A
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2068
Score = 76.3 bits (186), Expect = 2e-13
Identities = 86/362 (23%), Positives = 160/362 (44%), Gaps = 32/362 (8%)
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLL 353
E++ + + Q +A++LR ++++E K Q +E V+ E +++R + +EE L
Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1511
Query: 354 HAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNE----- 408
AE QA V++A++ + + E Q+KR K + E+ L E
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1571
Query: 409 --LQEERQRR----QEEKQARDEAVQERKR----ALEAER-QARVEELLMKRKEQEARIE 457
L+EE +RR E ++AR+EA +E +R A EA R + + EE+ ++ +A E
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631
Query: 458 QQRQEKEK-AREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+Q++E E+ AR E R+ LA +Q + E + +L ++ + R + E
Sbjct: 1632 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691
Query: 517 QRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRE 576
Q +++ L A T ++ + L V EV L S + +
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE------- 1744
Query: 577 NTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFR 636
+ R S++ + L + + E A AL EE ++ ++ A++ AR
Sbjct: 1745 ----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAE 1798
Query: 637 AK 638
A+
Sbjct: 1799 AE 1800
Score = 73.2 bits (178), Expect = 1e-12
Identities = 117/531 (22%), Positives = 224/531 (42%), Gaps = 80/531 (15%)
Query: 107 DVKNSGSIRDNYVRTSEISAVHIDTE------CVSVMLQAGTPPLQVNEEKFPAEKARIE 160
+ + G + VR E++ ++ + L A +++ E E+ R
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1699
Query: 161 NEMDPSDISNSMAEVLAKKEELADRLEK--ANEEAIASAIAEEEQLTREIEAEENNDINI 218
E + + + A K++EL L K A E + ++ A E+ +R + +
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759
Query: 219 ETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHG 278
E + + A E+ RQ + EE+ AR
Sbjct: 1760 EAGRFRELAEEAARLRAL----------------AEEAKRQR----QLAEEDAARQRAEA 1799
Query: 279 IH-MHEKLSS---PSRKRTIAE-SKKKHEEKQMKAQQL-------REKLREEKTLKLQKL 326
+ EKL++ +R +T AE + K+ E + + ++L R +L E+ +
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859
Query: 327 LEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN------EI 380
ER +RK + L++++ ++E+ L +R+V+ + + KA E+A E+
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQ---RRQVEEEILALKASFEKAAAGKAELELEL 1916
Query: 381 AFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ-------ARDEAVQERKRA 433
I + R ++L+ QR +EER RR+E ++ A +EA ++RK A
Sbjct: 1917 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEER-RRREAEERVQKSLAAEEEAARQRKAA 1975
Query: 434 LEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDR---EERLAALTAAQ 489
LE VE L K K +EAR ++R E+E AR+ A+E A+ R EE+ A Q
Sbjct: 1976 LE-----EVERL--KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2028
Query: 490 QEAMEELQKKIQLKHD---------ESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
+E +ELQ+ +Q + E+ RR E+ E+ + +A ++ + A +L
Sbjct: 2029 KE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2086
Query: 541 PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVE 591
++ + ++E L + ++A E +++ ++ +D E+E
Sbjct: 2087 QSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEME 2136
Score = 67.0 bits (162), Expect = 1e-10
Identities = 95/456 (20%), Positives = 186/456 (40%), Gaps = 65/456 (14%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEE--Q 203
QV +E E + + + + + A+ E A + + EE + + EE +
Sbjct: 2151 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2210
Query: 204 LTREIEAEENNDINIETDNDSDF----SASMGSGSVSFCGMSMDWNDVLADYE-ARESWR 258
L IEAE I + DN F + M + +S+ + + A E
Sbjct: 2211 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2270
Query: 259 QNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAE--SKKKHEEKQMKAQQLREKLR 316
Q + + + +E + + + +++ +A+ +++ E+K+ AQQL E+
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE-- 2328
Query: 317 EEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQE---- 372
T Q+ LE E+ R+ + +R ++ ++ A+ + E Q K+A+E
Sbjct: 2329 ---TQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2384
Query: 373 ----EEAKVNEIAFINTLEAQNKRHD-----VLSKLKEYEQRLNELQEER---QRRQEEK 420
E A ++ + TLE Q ++ D + + E E+ +LQ+E Q + EE
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444
Query: 421 QA--------------------------RDEAVQERKRALEAERQARVEELLMKRKEQEA 454
Q R+ +++ K LE Q V + R+EQ+
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504
Query: 455 RIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEEL------QKKIQLKHDESI 508
+QQ+ E+E+ R A+ E AR R+ +QE +++L Q+++ + ++ +
Sbjct: 2505 --QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2562
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYER 544
R ++ +E++ A S A+ A K P R
Sbjct: 2563 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2598
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/383 (22%), Positives = 162/383 (42%), Gaps = 52/383 (13%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEE--L 340
E ++SP++K + + ++ + LR E TL Q + + +R+ +EE L
Sbjct: 1262 EPVASPAKKPKVQSGSESVIQEYV---DLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1318
Query: 341 LDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLK 400
+Q+R E+L E E Q Q AQ + AQ +R + K
Sbjct: 1319 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAK--------------AQAER-----EAK 1359
Query: 401 EYEQRLNELQEERQRR----QEEKQARDEAVQERKRALEAE-----RQARVEELLMKRKE 451
E +QR+ E R+ Q++K++ E +Q+ +++ EAE RQA E R E
Sbjct: 1360 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1419
Query: 452 QEARI---EQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESI 508
+E R+ + + E+++ + + R R E A QE E L++++Q DES
Sbjct: 1420 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQ 1476
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAP----KLTPYERKKQCSLCNVLISSEVYLFSH 564
R+ ++E AE + R +L E +++ V + +V +
Sbjct: 1477 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1536
Query: 565 VKGRKHQQAVR-------ENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
R + ++ E T+ R L +E V L++ + + A AE ++
Sbjct: 1537 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-AERRAQQQAEAERAREEA 1595
Query: 618 ERQKNKKKAKKIKA-RMNFRAKE 639
ER+ + + K +A R+ +A+E
Sbjct: 1596 ERELERWQLKANEALRLRLQAEE 1618
Score = 61.2 bits (147), Expect = 5e-09
Identities = 142/650 (21%), Positives = 247/650 (38%), Gaps = 143/650 (22%)
Query: 145 LQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQL 204
L+ + EK A KA +E E+ I ++ + L KE+ LE A + +A AEEE+
Sbjct: 1898 LKASFEKAAAGKAELELEL--GRIRSNAEDTLRSKEQA--ELEAARQRQLA---AEEERR 1950
Query: 205 TREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWG 264
RE E + E + A++ + + A E R+
Sbjct: 1951 RREAEERVQKSLAAEEEAARQRKAALE-----------EVERLKAKVEEARRLRERA--- 1996
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ 324
E+E AR + ++KR AE K Q K Q+L++ L++E+++ Q
Sbjct: 1997 ---EQESAR-------QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046
Query: 325 ---------KLLEREKDVRKWKEELLDQRRRMMEEK-----------------LLHAEFK 358
+ E ++ R E Q RR +EE AE
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2106
Query: 359 REVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKR--HDVLSKLKEYEQRLNELQEERQRR 416
R+ Q ++AQ E+A + + + ++K+ L + + EQ L L+ + +
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166
Query: 417 QEEKQARDEAVQERK-RALEAERQ----------------------ARVEE----LLMKR 449
+K DE +Q K A EA RQ AR+E L+++
Sbjct: 2167 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2226
Query: 450 KEQEARIEQQRQEKEK----------------------AREDAARERARD----REERLA 483
K+ R Q+ EK K A ED A++RA +E+ A
Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2286
Query: 484 ALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYE 543
A + +A EL ++ + E RR E EQ ++ AE + G + E
Sbjct: 2287 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE-------AE 2339
Query: 544 RKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
R++Q + + L V QA E + + R+ ++E E L +
Sbjct: 2340 RQRQLEMS----AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2395
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLA 663
V E +RQ++ A++++ + +E E L + +AKL +L
Sbjct: 2396 VTLVQTLEI-----QRQQSDHDAERLREAIAELEREKEKLQQ----------EAKLLQLK 2440
Query: 664 KDLLKQVQ----VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQ 709
+ ++ VQ +Q++ + + +S D L + R +E+E + FQ
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQ 2489
Score = 61.2 bits (147), Expect = 5e-09
Identities = 79/349 (22%), Positives = 160/349 (45%), Gaps = 45/349 (12%)
Query: 173 AEVLAKKEELAD---RLEKANEEAIASAIAEEEQ-LTREIEAEENNDINIETDNDSDFSA 228
AE+L +++ELA R + ++E +A +AEE Q R +EAE + + + +
Sbjct: 2297 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER---- 2352
Query: 229 SMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD-------IVEEEPARPPGHGIHM 281
+ M A+ +A+ +Q G+ +E+ I
Sbjct: 2353 ------LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2406
Query: 282 HEKLSSPSRKR-TIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKW---- 336
+ R R IAE +++ E+ Q +A+ L+ K E +T++ ++LL+ + +++
Sbjct: 2407 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2466
Query: 337 KEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ---EEEAKVNEIAFINTLEAQNKRH 393
K+ LL + R + +EK K E Q V KAQ EE+ + + + + +R
Sbjct: 2467 KDSLLQRERFIEQEKA-----KLEQLFQDEVAKAQQLREEQQRQQQ-------QMEQERQ 2514
Query: 394 DVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQE 453
+++ ++E +R +E +E +R+QEE Q ++ ++++ L E Q E+L + E++
Sbjct: 2515 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL--LEEQ 2572
Query: 454 ARIEQQRQEKEKAREDAARERARDREERL--AALTAAQQEAMEELQKKI 500
R E+ A + AA + + + L A A + + + L++K+
Sbjct: 2573 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2621
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 47/370 (12%)
Query: 315 LREEKTLKLQKLLEREKDVRKWKEEL----LDQRRRMMEEKLLHAEFKREVQLQAIVKKA 370
LR E L L KL + + E+L L R E++L A ++ + QA+
Sbjct: 1031 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1090
Query: 371 QEEEAKVNEIAFINT-LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQE 429
E EA + + EAQ D L ++ + E+ E Q+R E+ E +E
Sbjct: 1091 PELEATKASLKKLRAQAEAQQPTFDAL---RDELRGAQEVGERLQQRHGERDVEVERWRE 1147
Query: 430 RKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDREERLAALTAA 488
R L QA + + ++++E E Q R +E A A + AR R+E++ A+ A
Sbjct: 1148 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1207
Query: 489 QQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQ- 547
+A+ E ++ Q +E I RH E++E+ + A + +A DY +L Y+ + +
Sbjct: 1208 DSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYI---NAIKDYELQLVTYKAQLEP 1263
Query: 548 ----CSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
V SE + +V R H + TS +YI I
Sbjct: 1264 VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----------------QYIKFI- 1305
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ--R 661
+E L+ EE + + A++ +A R E E+ +E + +++ +AK Q R
Sbjct: 1306 ------SETLRRMEEEE---RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1356
Query: 662 LAKDLLKQVQ 671
AK+L +++Q
Sbjct: 1357 EAKELQQRMQ 1366
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 77.4 bits (189), Expect = 7e-14
Identities = 127/600 (21%), Positives = 249/600 (41%), Gaps = 49/600 (8%)
Query: 156 KARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENND 215
KA E + ++ E+ + EE RL +A E E R EAE +
Sbjct: 1659 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1718
Query: 216 INIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARP- 274
+ + S+ V+ + E E Q + + EE R
Sbjct: 1719 RASFAEKTAQLERSLQEEHVAVAQLR----------EEAERRAQQQAEAERAREEAEREL 1768
Query: 275 ------PGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLE 328
+ + + ++++++A+++ + ++++ + + R EE+ ++ ++L E
Sbjct: 1769 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828
Query: 329 REKDVRKWKEELLDQRRRMMEEKL--LHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
+E + ++ E Q+R E++L L AE ++ Q + ++ +EE A++ A
Sbjct: 1829 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL---EEELARLQREA----A 1881
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELL 446
A KR ++ ++L + + L + R +EE ++ E ++R LEAE R EL
Sbjct: 1882 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR---LEAEA-GRFRELA 1937
Query: 447 MKRKEQEARIEQQRQEKEKAREDAARERA---RDREERLAALTAAQQEAME-ELQKKIQL 502
+ A E+ +++++ A EDAAR+RA R E+LAA+ A + E E+ K +
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1997
Query: 503 KHDESIRRHME----QIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSE 558
+E +RR E Q + +E+AA+ + K + E ++Q L +
Sbjct: 1998 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057
Query: 559 VYLFSHVKGRK--HQQAVRENTSIQ---GRELSDEEVEHLSLKKYIIDIVVESTAPAE-- 611
+ + K ++A ++ GR S+ E S ++ ++ + AE
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117
Query: 612 -ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQV 670
++ EER + A++ AR A E ++ K + + Q A+ L
Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177
Query: 671 QVQDSGSWANNKVS--ALDRTLGEITRILEKE-NVADQIAFQAAGGLTALEHILQAVVPA 727
+ A K A+ + E+ + L++E +V DQ+ +A A E +A V A
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2237
Score = 76.3 bits (186), Expect = 2e-13
Identities = 86/362 (23%), Positives = 160/362 (44%), Gaps = 32/362 (8%)
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLL 353
E++ + + Q +A++LR ++++E K Q +E V+ E +++R + +EE L
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680
Query: 354 HAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNE----- 408
AE QA V++A++ + + E Q+KR K + E+ L E
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740
Query: 409 --LQEERQRR----QEEKQARDEAVQERKR----ALEAER-QARVEELLMKRKEQEARIE 457
L+EE +RR E ++AR+EA +E +R A EA R + + EE+ ++ +A E
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800
Query: 458 QQRQEKEK-AREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+Q++E E+ AR E R+ LA +Q + E + +L ++ + R + E
Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860
Query: 517 QRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRE 576
Q +++ L A T ++ + L V EV L S + +
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE------- 1913
Query: 577 NTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFR 636
+ R S++ + L + + E A AL EE ++ ++ A++ AR
Sbjct: 1914 ----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAE 1967
Query: 637 AK 638
A+
Sbjct: 1968 AE 1969
Score = 73.2 bits (178), Expect = 1e-12
Identities = 117/531 (22%), Positives = 224/531 (42%), Gaps = 80/531 (15%)
Query: 107 DVKNSGSIRDNYVRTSEISAVHIDTE------CVSVMLQAGTPPLQVNEEKFPAEKARIE 160
+ + G + VR E++ ++ + L A +++ E E+ R
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868
Query: 161 NEMDPSDISNSMAEVLAKKEELADRLEK--ANEEAIASAIAEEEQLTREIEAEENNDINI 218
E + + + A K++EL L K A E + ++ A E+ +R + +
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928
Query: 219 ETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHG 278
E + + A E+ RQ + EE+ AR
Sbjct: 1929 EAGRFRELAEEAARLRAL----------------AEEAKRQR----QLAEEDAARQRAEA 1968
Query: 279 IH-MHEKLSS---PSRKRTIAE-SKKKHEEKQMKAQQL-------REKLREEKTLKLQKL 326
+ EKL++ +R +T AE + K+ E + + ++L R +L E+ +
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028
Query: 327 LEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN------EI 380
ER +RK + L++++ ++E+ L +R+V+ + + KA E+A E+
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQ---RRQVEEEILALKASFEKAAAGKAELELEL 2085
Query: 381 AFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ-------ARDEAVQERKRA 433
I + R ++L+ QR +EER RR+E ++ A +EA ++RK A
Sbjct: 2086 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEER-RRREAEERVQKSLAAEEEAARQRKAA 2144
Query: 434 LEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDR---EERLAALTAAQ 489
LE VE L K K +EAR ++R E+E AR+ A+E A+ R EE+ A Q
Sbjct: 2145 LE-----EVERL--KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2197
Query: 490 QEAMEELQKKIQLKHD---------ESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
+E +ELQ+ +Q + E+ RR E+ E+ + +A ++ + A +L
Sbjct: 2198 KE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2255
Query: 541 PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVE 591
++ + ++E L + ++A E +++ ++ +D E+E
Sbjct: 2256 QSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305
Score = 67.0 bits (162), Expect = 1e-10
Identities = 95/456 (20%), Positives = 186/456 (40%), Gaps = 65/456 (14%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEE--Q 203
QV +E E + + + + + A+ E A + + EE + + EE +
Sbjct: 2320 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2379
Query: 204 LTREIEAEENNDINIETDNDSDF----SASMGSGSVSFCGMSMDWNDVLADYE-ARESWR 258
L IEAE I + DN F + M + +S+ + + A E
Sbjct: 2380 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2439
Query: 259 QNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAE--SKKKHEEKQMKAQQLREKLR 316
Q + + + +E + + + +++ +A+ +++ E+K+ AQQL E+
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE-- 2497
Query: 317 EEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQE---- 372
T Q+ LE E+ R+ + +R ++ ++ A+ + E Q K+A+E
Sbjct: 2498 ---TQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2553
Query: 373 ----EEAKVNEIAFINTLEAQNKRHD-----VLSKLKEYEQRLNELQEER---QRRQEEK 420
E A ++ + TLE Q ++ D + + E E+ +LQ+E Q + EE
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613
Query: 421 QA--------------------------RDEAVQERKRALEAERQARVEELLMKRKEQEA 454
Q R+ +++ K LE Q V + R+EQ+
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2673
Query: 455 RIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEEL------QKKIQLKHDESI 508
+QQ+ E+E+ R A+ E AR R+ +QE +++L Q+++ + ++ +
Sbjct: 2674 --QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2731
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYER 544
R ++ +E++ A S A+ A K P R
Sbjct: 2732 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2767
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/383 (22%), Positives = 162/383 (42%), Gaps = 52/383 (13%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEE--L 340
E ++SP++K + + ++ + LR E TL Q + + +R+ +EE L
Sbjct: 1431 EPVASPAKKPKVQSGSESVIQEYV---DLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1487
Query: 341 LDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLK 400
+Q+R E+L E E Q Q AQ + AQ +R + K
Sbjct: 1488 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAK--------------AQAER-----EAK 1528
Query: 401 EYEQRLNELQEERQRR----QEEKQARDEAVQERKRALEAE-----RQARVEELLMKRKE 451
E +QR+ E R+ Q++K++ E +Q+ +++ EAE RQA E R E
Sbjct: 1529 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588
Query: 452 QEARI---EQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESI 508
+E R+ + + E+++ + + R R E A QE E L++++Q DES
Sbjct: 1589 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQ 1645
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAP----KLTPYERKKQCSLCNVLISSEVYLFSH 564
R+ ++E AE + R +L E +++ V + +V +
Sbjct: 1646 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1705
Query: 565 VKGRKHQQAVR-------ENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
R + ++ E T+ R L +E V L++ + + A AE ++
Sbjct: 1706 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-AERRAQQQAEAERAREEA 1764
Query: 618 ERQKNKKKAKKIKA-RMNFRAKE 639
ER+ + + K +A R+ +A+E
Sbjct: 1765 ERELERWQLKANEALRLRLQAEE 1787
Score = 61.2 bits (147), Expect = 5e-09
Identities = 142/650 (21%), Positives = 247/650 (38%), Gaps = 143/650 (22%)
Query: 145 LQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQL 204
L+ + EK A KA +E E+ I ++ + L KE+ LE A + +A AEEE+
Sbjct: 2067 LKASFEKAAAGKAELELEL--GRIRSNAEDTLRSKEQA--ELEAARQRQLA---AEEERR 2119
Query: 205 TREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWG 264
RE E + E + A++ + + A E R+
Sbjct: 2120 RREAEERVQKSLAAEEEAARQRKAALE-----------EVERLKAKVEEARRLRERA--- 2165
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ 324
E+E AR + ++KR AE K Q K Q+L++ L++E+++ Q
Sbjct: 2166 ---EQESAR-------QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215
Query: 325 ---------KLLEREKDVRKWKEELLDQRRRMMEEK-----------------LLHAEFK 358
+ E ++ R E Q RR +EE AE
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275
Query: 359 REVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKR--HDVLSKLKEYEQRLNELQEERQRR 416
R+ Q ++AQ E+A + + + ++K+ L + + EQ L L+ + +
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335
Query: 417 QEEKQARDEAVQERK-RALEAERQ----------------------ARVEE----LLMKR 449
+K DE +Q K A EA RQ AR+E L+++
Sbjct: 2336 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2395
Query: 450 KEQEARIEQQRQEKEK----------------------AREDAARERARD----REERLA 483
K+ R Q+ EK K A ED A++RA +E+ A
Sbjct: 2396 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2455
Query: 484 ALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYE 543
A + +A EL ++ + E RR E EQ ++ AE + G + E
Sbjct: 2456 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE-------AE 2508
Query: 544 RKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
R++Q + + L V QA E + + R+ ++E E L +
Sbjct: 2509 RQRQLEMS----AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLA 663
V E +RQ++ A++++ + +E E L + +AKL +L
Sbjct: 2565 VTLVQTLEI-----QRQQSDHDAERLREAIAELEREKEKLQQ----------EAKLLQLK 2609
Query: 664 KDLLKQVQ----VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQ 709
+ ++ VQ +Q++ + + +S D L + R +E+E + FQ
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQ 2658
Score = 61.2 bits (147), Expect = 5e-09
Identities = 79/349 (22%), Positives = 160/349 (45%), Gaps = 45/349 (12%)
Query: 173 AEVLAKKEELAD---RLEKANEEAIASAIAEEEQ-LTREIEAEENNDINIETDNDSDFSA 228
AE+L +++ELA R + ++E +A +AEE Q R +EAE + + + +
Sbjct: 2466 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER---- 2521
Query: 229 SMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD-------IVEEEPARPPGHGIHM 281
+ M A+ +A+ +Q G+ +E+ I
Sbjct: 2522 ------LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2575
Query: 282 HEKLSSPSRKR-TIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKW---- 336
+ R R IAE +++ E+ Q +A+ L+ K E +T++ ++LL+ + +++
Sbjct: 2576 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2635
Query: 337 KEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ---EEEAKVNEIAFINTLEAQNKRH 393
K+ LL + R + +EK K E Q V KAQ EE+ + + + + +R
Sbjct: 2636 KDSLLQRERFIEQEKA-----KLEQLFQDEVAKAQQLREEQQRQQQ-------QMEQERQ 2683
Query: 394 DVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQE 453
+++ ++E +R +E +E +R+QEE Q ++ ++++ L E Q E+L + E++
Sbjct: 2684 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL--LEEQ 2741
Query: 454 ARIEQQRQEKEKAREDAARERARDREERL--AALTAAQQEAMEELQKKI 500
R E+ A + AA + + + L A A + + + L++K+
Sbjct: 2742 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2790
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 47/370 (12%)
Query: 315 LREEKTLKLQKLLEREKDVRKWKEEL----LDQRRRMMEEKLLHAEFKREVQLQAIVKKA 370
LR E L L KL + + E+L L R E++L A ++ + QA+
Sbjct: 1200 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1259
Query: 371 QEEEAKVNEIAFINT-LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQE 429
E EA + + EAQ D L ++ + E+ E Q+R E+ E +E
Sbjct: 1260 PELEATKASLKKLRAQAEAQQPTFDAL---RDELRGAQEVGERLQQRHGERDVEVERWRE 1316
Query: 430 RKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDREERLAALTAA 488
R L QA + + ++++E E Q R +E A A + AR R+E++ A+ A
Sbjct: 1317 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1376
Query: 489 QQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQ- 547
+A+ E ++ Q +E I RH E++E+ + A + +A DY +L Y+ + +
Sbjct: 1377 DSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYI---NAIKDYELQLVTYKAQLEP 1432
Query: 548 ----CSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
V SE + +V R H + TS +YI I
Sbjct: 1433 VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----------------QYIKFI- 1474
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ--R 661
+E L+ EE + + A++ +A R E E+ +E + +++ +AK Q R
Sbjct: 1475 ------SETLRRMEEEE---RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1525
Query: 662 LAKDLLKQVQ 671
AK+L +++Q
Sbjct: 1526 EAKELQQRMQ 1535
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 77.4 bits (189), Expect = 7e-14
Identities = 127/600 (21%), Positives = 249/600 (41%), Gaps = 49/600 (8%)
Query: 156 KARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENND 215
KA E + ++ E+ + EE RL +A E E R EAE +
Sbjct: 1500 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1559
Query: 216 INIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARP- 274
+ + S+ V+ + E E Q + + EE R
Sbjct: 1560 RASFAEKTAQLERSLQEEHVAVAQLR----------EEAERRAQQQAEAERAREEAEREL 1609
Query: 275 ------PGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLE 328
+ + + ++++++A+++ + ++++ + + R EE+ ++ ++L E
Sbjct: 1610 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
Query: 329 REKDVRKWKEELLDQRRRMMEEKL--LHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
+E + ++ E Q+R E++L L AE ++ Q + ++ +EE A++ A
Sbjct: 1670 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL---EEELARLQREA----A 1722
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELL 446
A KR ++ ++L + + L + R +EE ++ E ++R LEAE R EL
Sbjct: 1723 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR---LEAEA-GRFRELA 1778
Query: 447 MKRKEQEARIEQQRQEKEKAREDAARERA---RDREERLAALTAAQQEAME-ELQKKIQL 502
+ A E+ +++++ A EDAAR+RA R E+LAA+ A + E E+ K +
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1838
Query: 503 KHDESIRRHME----QIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSE 558
+E +RR E Q + +E+AA+ + K + E ++Q L +
Sbjct: 1839 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898
Query: 559 VYLFSHVKGRK--HQQAVRENTSIQ---GRELSDEEVEHLSLKKYIIDIVVESTAPAE-- 611
+ + K ++A ++ GR S+ E S ++ ++ + AE
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
Query: 612 -ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQV 670
++ EER + A++ AR A E ++ K + + Q A+ L
Sbjct: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
Query: 671 QVQDSGSWANNKVS--ALDRTLGEITRILEKE-NVADQIAFQAAGGLTALEHILQAVVPA 727
+ A K A+ + E+ + L++E +V DQ+ +A A E +A V A
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2078
Score = 76.3 bits (186), Expect = 2e-13
Identities = 86/362 (23%), Positives = 160/362 (44%), Gaps = 32/362 (8%)
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLL 353
E++ + + Q +A++LR ++++E K Q +E V+ E +++R + +EE L
Sbjct: 1462 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1521
Query: 354 HAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNE----- 408
AE QA V++A++ + + E Q+KR K + E+ L E
Sbjct: 1522 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1581
Query: 409 --LQEERQRR----QEEKQARDEAVQERKR----ALEAER-QARVEELLMKRKEQEARIE 457
L+EE +RR E ++AR+EA +E +R A EA R + + EE+ ++ +A E
Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641
Query: 458 QQRQEKEK-AREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+Q++E E+ AR E R+ LA +Q + E + +L ++ + R + E
Sbjct: 1642 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1701
Query: 517 QRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRE 576
Q +++ L A T ++ + L V EV L S + +
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE------- 1754
Query: 577 NTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFR 636
+ R S++ + L + + E A AL EE ++ ++ A++ AR
Sbjct: 1755 ----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAE 1808
Query: 637 AK 638
A+
Sbjct: 1809 AE 1810
Score = 73.2 bits (178), Expect = 1e-12
Identities = 117/531 (22%), Positives = 224/531 (42%), Gaps = 80/531 (15%)
Query: 107 DVKNSGSIRDNYVRTSEISAVHIDTE------CVSVMLQAGTPPLQVNEEKFPAEKARIE 160
+ + G + VR E++ ++ + L A +++ E E+ R
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
Query: 161 NEMDPSDISNSMAEVLAKKEELADRLEK--ANEEAIASAIAEEEQLTREIEAEENNDINI 218
E + + + A K++EL L K A E + ++ A E+ +R + +
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
Query: 219 ETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHG 278
E + + A E+ RQ + EE+ AR
Sbjct: 1770 EAGRFRELAEEAARLRAL----------------AEEAKRQR----QLAEEDAARQRAEA 1809
Query: 279 IH-MHEKLSS---PSRKRTIAE-SKKKHEEKQMKAQQL-------REKLREEKTLKLQKL 326
+ EKL++ +R +T AE + K+ E + + ++L R +L E+ +
Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1869
Query: 327 LEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN------EI 380
ER +RK + L++++ ++E+ L +R+V+ + + KA E+A E+
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQ---RRQVEEEILALKASFEKAAAGKAELELEL 1926
Query: 381 AFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ-------ARDEAVQERKRA 433
I + R ++L+ QR +EER RR+E ++ A +EA ++RK A
Sbjct: 1927 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEER-RRREAEERVQKSLAAEEEAARQRKAA 1985
Query: 434 LEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDR---EERLAALTAAQ 489
LE VE L K K +EAR ++R E+E AR+ A+E A+ R EE+ A Q
Sbjct: 1986 LE-----EVERL--KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2038
Query: 490 QEAMEELQKKIQLKHD---------ESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
+E +ELQ+ +Q + E+ RR E+ E+ + +A ++ + A +L
Sbjct: 2039 KE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2096
Query: 541 PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVE 591
++ + ++E L + ++A E +++ ++ +D E+E
Sbjct: 2097 QSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEME 2146
Score = 67.0 bits (162), Expect = 1e-10
Identities = 95/456 (20%), Positives = 186/456 (40%), Gaps = 65/456 (14%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEE--Q 203
QV +E E + + + + + A+ E A + + EE + + EE +
Sbjct: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220
Query: 204 LTREIEAEENNDINIETDNDSDF----SASMGSGSVSFCGMSMDWNDVLADYE-ARESWR 258
L IEAE I + DN F + M + +S+ + + A E
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280
Query: 259 QNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAE--SKKKHEEKQMKAQQLREKLR 316
Q + + + +E + + + +++ +A+ +++ E+K+ AQQL E+
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE-- 2338
Query: 317 EEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQE---- 372
T Q+ LE E+ R+ + +R ++ ++ A+ + E Q K+A+E
Sbjct: 2339 ---TQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2394
Query: 373 ----EEAKVNEIAFINTLEAQNKRHD-----VLSKLKEYEQRLNELQEER---QRRQEEK 420
E A ++ + TLE Q ++ D + + E E+ +LQ+E Q + EE
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454
Query: 421 QA--------------------------RDEAVQERKRALEAERQARVEELLMKRKEQEA 454
Q R+ +++ K LE Q V + R+EQ+
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2514
Query: 455 RIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEEL------QKKIQLKHDESI 508
+QQ+ E+E+ R A+ E AR R+ +QE +++L Q+++ + ++ +
Sbjct: 2515 --QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2572
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYER 544
R ++ +E++ A S A+ A K P R
Sbjct: 2573 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2608
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/383 (22%), Positives = 162/383 (42%), Gaps = 52/383 (13%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEE--L 340
E ++SP++K + + ++ + LR E TL Q + + +R+ +EE L
Sbjct: 1272 EPVASPAKKPKVQSGSESVIQEYV---DLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1328
Query: 341 LDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLK 400
+Q+R E+L E E Q Q AQ + AQ +R + K
Sbjct: 1329 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAK--------------AQAER-----EAK 1369
Query: 401 EYEQRLNELQEERQRR----QEEKQARDEAVQERKRALEAE-----RQARVEELLMKRKE 451
E +QR+ E R+ Q++K++ E +Q+ +++ EAE RQA E R E
Sbjct: 1370 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429
Query: 452 QEARI---EQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESI 508
+E R+ + + E+++ + + R R E A QE E L++++Q DES
Sbjct: 1430 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQ 1486
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAP----KLTPYERKKQCSLCNVLISSEVYLFSH 564
R+ ++E AE + R +L E +++ V + +V +
Sbjct: 1487 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1546
Query: 565 VKGRKHQQAVR-------ENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
R + ++ E T+ R L +E V L++ + + A AE ++
Sbjct: 1547 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-AERRAQQQAEAERAREEA 1605
Query: 618 ERQKNKKKAKKIKA-RMNFRAKE 639
ER+ + + K +A R+ +A+E
Sbjct: 1606 ERELERWQLKANEALRLRLQAEE 1628
Score = 61.2 bits (147), Expect = 5e-09
Identities = 142/650 (21%), Positives = 247/650 (38%), Gaps = 143/650 (22%)
Query: 145 LQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQL 204
L+ + EK A KA +E E+ I ++ + L KE+ LE A + +A AEEE+
Sbjct: 1908 LKASFEKAAAGKAELELEL--GRIRSNAEDTLRSKEQA--ELEAARQRQLA---AEEERR 1960
Query: 205 TREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWG 264
RE E + E + A++ + + A E R+
Sbjct: 1961 RREAEERVQKSLAAEEEAARQRKAALE-----------EVERLKAKVEEARRLRERA--- 2006
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ 324
E+E AR + ++KR AE K Q K Q+L++ L++E+++ Q
Sbjct: 2007 ---EQESAR-------QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056
Query: 325 ---------KLLEREKDVRKWKEELLDQRRRMMEEK-----------------LLHAEFK 358
+ E ++ R E Q RR +EE AE
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116
Query: 359 REVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKR--HDVLSKLKEYEQRLNELQEERQRR 416
R+ Q ++AQ E+A + + + ++K+ L + + EQ L L+ + +
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176
Query: 417 QEEKQARDEAVQERK-RALEAERQ----------------------ARVEE----LLMKR 449
+K DE +Q K A EA RQ AR+E L+++
Sbjct: 2177 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2236
Query: 450 KEQEARIEQQRQEKEK----------------------AREDAARERARD----REERLA 483
K+ R Q+ EK K A ED A++RA +E+ A
Sbjct: 2237 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2296
Query: 484 ALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYE 543
A + +A EL ++ + E RR E EQ ++ AE + G + E
Sbjct: 2297 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE-------AE 2349
Query: 544 RKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
R++Q + + L V QA E + + R+ ++E E L +
Sbjct: 2350 RQRQLEMS----AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLA 663
V E +RQ++ A++++ + +E E L + +AKL +L
Sbjct: 2406 VTLVQTLEI-----QRQQSDHDAERLREAIAELEREKEKLQQ----------EAKLLQLK 2450
Query: 664 KDLLKQVQ----VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQ 709
+ ++ VQ +Q++ + + +S D L + R +E+E + FQ
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQ 2499
Score = 61.2 bits (147), Expect = 5e-09
Identities = 79/349 (22%), Positives = 160/349 (45%), Gaps = 45/349 (12%)
Query: 173 AEVLAKKEELAD---RLEKANEEAIASAIAEEEQ-LTREIEAEENNDINIETDNDSDFSA 228
AE+L +++ELA R + ++E +A +AEE Q R +EAE + + + +
Sbjct: 2307 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER---- 2362
Query: 229 SMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD-------IVEEEPARPPGHGIHM 281
+ M A+ +A+ +Q G+ +E+ I
Sbjct: 2363 ------LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2416
Query: 282 HEKLSSPSRKR-TIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKW---- 336
+ R R IAE +++ E+ Q +A+ L+ K E +T++ ++LL+ + +++
Sbjct: 2417 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2476
Query: 337 KEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ---EEEAKVNEIAFINTLEAQNKRH 393
K+ LL + R + +EK K E Q V KAQ EE+ + + + + +R
Sbjct: 2477 KDSLLQRERFIEQEKA-----KLEQLFQDEVAKAQQLREEQQRQQQ-------QMEQERQ 2524
Query: 394 DVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQE 453
+++ ++E +R +E +E +R+QEE Q ++ ++++ L E Q E+L + E++
Sbjct: 2525 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL--LEEQ 2582
Query: 454 ARIEQQRQEKEKAREDAARERARDREERL--AALTAAQQEAMEELQKKI 500
R E+ A + AA + + + L A A + + + L++K+
Sbjct: 2583 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2631
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 47/370 (12%)
Query: 315 LREEKTLKLQKLLEREKDVRKWKEEL----LDQRRRMMEEKLLHAEFKREVQLQAIVKKA 370
LR E L L KL + + E+L L R E++L A ++ + QA+
Sbjct: 1041 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1100
Query: 371 QEEEAKVNEIAFINT-LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQE 429
E EA + + EAQ D L ++ + E+ E Q+R E+ E +E
Sbjct: 1101 PELEATKASLKKLRAQAEAQQPTFDAL---RDELRGAQEVGERLQQRHGERDVEVERWRE 1157
Query: 430 RKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDREERLAALTAA 488
R L QA + + ++++E E Q R +E A A + AR R+E++ A+ A
Sbjct: 1158 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1217
Query: 489 QQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQ- 547
+A+ E ++ Q +E I RH E++E+ + A + +A DY +L Y+ + +
Sbjct: 1218 DSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYI---NAIKDYELQLVTYKAQLEP 1273
Query: 548 ----CSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
V SE + +V R H + TS +YI I
Sbjct: 1274 VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----------------QYIKFI- 1315
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ--R 661
+E L+ EE + + A++ +A R E E+ +E + +++ +AK Q R
Sbjct: 1316 ------SETLRRMEEEE---RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1366
Query: 662 LAKDLLKQVQ 671
AK+L +++Q
Sbjct: 1367 EAKELQQRMQ 1376
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 77.4 bits (189), Expect = 7e-14
Identities = 127/600 (21%), Positives = 249/600 (41%), Gaps = 49/600 (8%)
Query: 156 KARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENND 215
KA E + ++ E+ + EE RL +A E E R EAE +
Sbjct: 1508 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1567
Query: 216 INIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARP- 274
+ + S+ V+ + E E Q + + EE R
Sbjct: 1568 RASFAEKTAQLERSLQEEHVAVAQLR----------EEAERRAQQQAEAERAREEAEREL 1617
Query: 275 ------PGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLE 328
+ + + ++++++A+++ + ++++ + + R EE+ ++ ++L E
Sbjct: 1618 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1677
Query: 329 REKDVRKWKEELLDQRRRMMEEKL--LHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
+E + ++ E Q+R E++L L AE ++ Q + ++ +EE A++ A
Sbjct: 1678 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL---EEELARLQREA----A 1730
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELL 446
A KR ++ ++L + + L + R +EE ++ E ++R LEAE R EL
Sbjct: 1731 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR---LEAEA-GRFRELA 1786
Query: 447 MKRKEQEARIEQQRQEKEKAREDAARERA---RDREERLAALTAAQQEAME-ELQKKIQL 502
+ A E+ +++++ A EDAAR+RA R E+LAA+ A + E E+ K +
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1846
Query: 503 KHDESIRRHME----QIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSE 558
+E +RR E Q + +E+AA+ + K + E ++Q L +
Sbjct: 1847 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1906
Query: 559 VYLFSHVKGRK--HQQAVRENTSIQ---GRELSDEEVEHLSLKKYIIDIVVESTAPAE-- 611
+ + K ++A ++ GR S+ E S ++ ++ + AE
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1966
Query: 612 -ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQV 670
++ EER + A++ AR A E ++ K + + Q A+ L
Sbjct: 1967 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026
Query: 671 QVQDSGSWANNKVS--ALDRTLGEITRILEKE-NVADQIAFQAAGGLTALEHILQAVVPA 727
+ A K A+ + E+ + L++E +V DQ+ +A A E +A V A
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2086
Score = 76.3 bits (186), Expect = 2e-13
Identities = 86/362 (23%), Positives = 160/362 (44%), Gaps = 32/362 (8%)
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLL 353
E++ + + Q +A++LR ++++E K Q +E V+ E +++R + +EE L
Sbjct: 1470 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1529
Query: 354 HAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNE----- 408
AE QA V++A++ + + E Q+KR K + E+ L E
Sbjct: 1530 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1589
Query: 409 --LQEERQRR----QEEKQARDEAVQERKR----ALEAER-QARVEELLMKRKEQEARIE 457
L+EE +RR E ++AR+EA +E +R A EA R + + EE+ ++ +A E
Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649
Query: 458 QQRQEKEK-AREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+Q++E E+ AR E R+ LA +Q + E + +L ++ + R + E
Sbjct: 1650 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1709
Query: 517 QRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRE 576
Q +++ L A T ++ + L V EV L S + +
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE------- 1762
Query: 577 NTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFR 636
+ R S++ + L + + E A AL EE ++ ++ A++ AR
Sbjct: 1763 ----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAE 1816
Query: 637 AK 638
A+
Sbjct: 1817 AE 1818
Score = 73.2 bits (178), Expect = 1e-12
Identities = 117/531 (22%), Positives = 224/531 (42%), Gaps = 80/531 (15%)
Query: 107 DVKNSGSIRDNYVRTSEISAVHIDTE------CVSVMLQAGTPPLQVNEEKFPAEKARIE 160
+ + G + VR E++ ++ + L A +++ E E+ R
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1717
Query: 161 NEMDPSDISNSMAEVLAKKEELADRLEK--ANEEAIASAIAEEEQLTREIEAEENNDINI 218
E + + + A K++EL L K A E + ++ A E+ +R + +
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777
Query: 219 ETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHG 278
E + + A E+ RQ + EE+ AR
Sbjct: 1778 EAGRFRELAEEAARLRAL----------------AEEAKRQR----QLAEEDAARQRAEA 1817
Query: 279 IH-MHEKLSS---PSRKRTIAE-SKKKHEEKQMKAQQL-------REKLREEKTLKLQKL 326
+ EKL++ +R +T AE + K+ E + + ++L R +L E+ +
Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1877
Query: 327 LEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN------EI 380
ER +RK + L++++ ++E+ L +R+V+ + + KA E+A E+
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQ---RRQVEEEILALKASFEKAAAGKAELELEL 1934
Query: 381 AFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ-------ARDEAVQERKRA 433
I + R ++L+ QR +EER RR+E ++ A +EA ++RK A
Sbjct: 1935 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEER-RRREAEERVQKSLAAEEEAARQRKAA 1993
Query: 434 LEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDR---EERLAALTAAQ 489
LE VE L K K +EAR ++R E+E AR+ A+E A+ R EE+ A Q
Sbjct: 1994 LE-----EVERL--KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2046
Query: 490 QEAMEELQKKIQLKHD---------ESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
+E +ELQ+ +Q + E+ RR E+ E+ + +A ++ + A +L
Sbjct: 2047 KE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2104
Query: 541 PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVE 591
++ + ++E L + ++A E +++ ++ +D E+E
Sbjct: 2105 QSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEME 2154
Score = 67.0 bits (162), Expect = 1e-10
Identities = 95/456 (20%), Positives = 186/456 (40%), Gaps = 65/456 (14%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEE--Q 203
QV +E E + + + + + A+ E A + + EE + + EE +
Sbjct: 2169 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2228
Query: 204 LTREIEAEENNDINIETDNDSDF----SASMGSGSVSFCGMSMDWNDVLADYE-ARESWR 258
L IEAE I + DN F + M + +S+ + + A E
Sbjct: 2229 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2288
Query: 259 QNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAE--SKKKHEEKQMKAQQLREKLR 316
Q + + + +E + + + +++ +A+ +++ E+K+ AQQL E+
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE-- 2346
Query: 317 EEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQE---- 372
T Q+ LE E+ R+ + +R ++ ++ A+ + E Q K+A+E
Sbjct: 2347 ---TQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2402
Query: 373 ----EEAKVNEIAFINTLEAQNKRHD-----VLSKLKEYEQRLNELQEER---QRRQEEK 420
E A ++ + TLE Q ++ D + + E E+ +LQ+E Q + EE
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462
Query: 421 QA--------------------------RDEAVQERKRALEAERQARVEELLMKRKEQEA 454
Q R+ +++ K LE Q V + R+EQ+
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2522
Query: 455 RIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEEL------QKKIQLKHDESI 508
+QQ+ E+E+ R A+ E AR R+ +QE +++L Q+++ + ++ +
Sbjct: 2523 --QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2580
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYER 544
R ++ +E++ A S A+ A K P R
Sbjct: 2581 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2616
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/383 (22%), Positives = 162/383 (42%), Gaps = 52/383 (13%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEE--L 340
E ++SP++K + + ++ + LR E TL Q + + +R+ +EE L
Sbjct: 1280 EPVASPAKKPKVQSGSESVIQEYV---DLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1336
Query: 341 LDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLK 400
+Q+R E+L E E Q Q AQ + AQ +R + K
Sbjct: 1337 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAK--------------AQAER-----EAK 1377
Query: 401 EYEQRLNELQEERQRR----QEEKQARDEAVQERKRALEAE-----RQARVEELLMKRKE 451
E +QR+ E R+ Q++K++ E +Q+ +++ EAE RQA E R E
Sbjct: 1378 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1437
Query: 452 QEARI---EQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESI 508
+E R+ + + E+++ + + R R E A QE E L++++Q DES
Sbjct: 1438 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQ 1494
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAP----KLTPYERKKQCSLCNVLISSEVYLFSH 564
R+ ++E AE + R +L E +++ V + +V +
Sbjct: 1495 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1554
Query: 565 VKGRKHQQAVR-------ENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
R + ++ E T+ R L +E V L++ + + A AE ++
Sbjct: 1555 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-AERRAQQQAEAERAREEA 1613
Query: 618 ERQKNKKKAKKIKA-RMNFRAKE 639
ER+ + + K +A R+ +A+E
Sbjct: 1614 ERELERWQLKANEALRLRLQAEE 1636
Score = 61.2 bits (147), Expect = 5e-09
Identities = 142/650 (21%), Positives = 247/650 (38%), Gaps = 143/650 (22%)
Query: 145 LQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQL 204
L+ + EK A KA +E E+ I ++ + L KE+ LE A + +A AEEE+
Sbjct: 1916 LKASFEKAAAGKAELELEL--GRIRSNAEDTLRSKEQA--ELEAARQRQLA---AEEERR 1968
Query: 205 TREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWG 264
RE E + E + A++ + + A E R+
Sbjct: 1969 RREAEERVQKSLAAEEEAARQRKAALE-----------EVERLKAKVEEARRLRERA--- 2014
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ 324
E+E AR + ++KR AE K Q K Q+L++ L++E+++ Q
Sbjct: 2015 ---EQESAR-------QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064
Query: 325 ---------KLLEREKDVRKWKEELLDQRRRMMEEK-----------------LLHAEFK 358
+ E ++ R E Q RR +EE AE
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2124
Query: 359 REVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKR--HDVLSKLKEYEQRLNELQEERQRR 416
R+ Q ++AQ E+A + + + ++K+ L + + EQ L L+ + +
Sbjct: 2125 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2184
Query: 417 QEEKQARDEAVQERK-RALEAERQ----------------------ARVEE----LLMKR 449
+K DE +Q K A EA RQ AR+E L+++
Sbjct: 2185 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2244
Query: 450 KEQEARIEQQRQEKEK----------------------AREDAARERARD----REERLA 483
K+ R Q+ EK K A ED A++RA +E+ A
Sbjct: 2245 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2304
Query: 484 ALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYE 543
A + +A EL ++ + E RR E EQ ++ AE + G + E
Sbjct: 2305 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE-------AE 2357
Query: 544 RKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
R++Q + + L V QA E + + R+ ++E E L +
Sbjct: 2358 RQRQLEMS----AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2413
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLA 663
V E +RQ++ A++++ + +E E L + +AKL +L
Sbjct: 2414 VTLVQTLEI-----QRQQSDHDAERLREAIAELEREKEKLQQ----------EAKLLQLK 2458
Query: 664 KDLLKQVQ----VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQ 709
+ ++ VQ +Q++ + + +S D L + R +E+E + FQ
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQ 2507
Score = 61.2 bits (147), Expect = 5e-09
Identities = 79/349 (22%), Positives = 160/349 (45%), Gaps = 45/349 (12%)
Query: 173 AEVLAKKEELAD---RLEKANEEAIASAIAEEEQ-LTREIEAEENNDINIETDNDSDFSA 228
AE+L +++ELA R + ++E +A +AEE Q R +EAE + + + +
Sbjct: 2315 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER---- 2370
Query: 229 SMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD-------IVEEEPARPPGHGIHM 281
+ M A+ +A+ +Q G+ +E+ I
Sbjct: 2371 ------LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2424
Query: 282 HEKLSSPSRKR-TIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKW---- 336
+ R R IAE +++ E+ Q +A+ L+ K E +T++ ++LL+ + +++
Sbjct: 2425 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2484
Query: 337 KEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ---EEEAKVNEIAFINTLEAQNKRH 393
K+ LL + R + +EK K E Q V KAQ EE+ + + + + +R
Sbjct: 2485 KDSLLQRERFIEQEKA-----KLEQLFQDEVAKAQQLREEQQRQQQ-------QMEQERQ 2532
Query: 394 DVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQE 453
+++ ++E +R +E +E +R+QEE Q ++ ++++ L E Q E+L + E++
Sbjct: 2533 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL--LEEQ 2590
Query: 454 ARIEQQRQEKEKAREDAARERARDREERL--AALTAAQQEAMEELQKKI 500
R E+ A + AA + + + L A A + + + L++K+
Sbjct: 2591 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2639
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 47/370 (12%)
Query: 315 LREEKTLKLQKLLEREKDVRKWKEEL----LDQRRRMMEEKLLHAEFKREVQLQAIVKKA 370
LR E L L KL + + E+L L R E++L A ++ + QA+
Sbjct: 1049 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1108
Query: 371 QEEEAKVNEIAFINT-LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQE 429
E EA + + EAQ D L ++ + E+ E Q+R E+ E +E
Sbjct: 1109 PELEATKASLKKLRAQAEAQQPTFDAL---RDELRGAQEVGERLQQRHGERDVEVERWRE 1165
Query: 430 RKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDREERLAALTAA 488
R L QA + + ++++E E Q R +E A A + AR R+E++ A+ A
Sbjct: 1166 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1225
Query: 489 QQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQ- 547
+A+ E ++ Q +E I RH E++E+ + A + +A DY +L Y+ + +
Sbjct: 1226 DSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYI---NAIKDYELQLVTYKAQLEP 1281
Query: 548 ----CSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
V SE + +V R H + TS +YI I
Sbjct: 1282 VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----------------QYIKFI- 1323
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ--R 661
+E L+ EE + + A++ +A R E E+ +E + +++ +AK Q R
Sbjct: 1324 ------SETLRRMEEEE---RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1374
Query: 662 LAKDLLKQVQ 671
AK+L +++Q
Sbjct: 1375 EAKELQQRMQ 1384
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 77.4 bits (189), Expect = 7e-14
Identities = 127/600 (21%), Positives = 249/600 (41%), Gaps = 49/600 (8%)
Query: 156 KARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQLTREIEAEENND 215
KA E + ++ E+ + EE RL +A E E R EAE +
Sbjct: 1549 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSK 1608
Query: 216 INIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARP- 274
+ + S+ V+ + E E Q + + EE R
Sbjct: 1609 RASFAEKTAQLERSLQEEHVAVAQLR----------EEAERRAQQQAEAERAREEAEREL 1658
Query: 275 ------PGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLE 328
+ + + ++++++A+++ + ++++ + + R EE+ ++ ++L E
Sbjct: 1659 ERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1718
Query: 329 REKDVRKWKEELLDQRRRMMEEKL--LHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTL 386
+E + ++ E Q+R E++L L AE ++ Q + ++ +EE A++ A
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL---EEELARLQREA----A 1771
Query: 387 EAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELL 446
A KR ++ ++L + + L + R +EE ++ E ++R LEAE R EL
Sbjct: 1772 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR---LEAEA-GRFRELA 1827
Query: 447 MKRKEQEARIEQQRQEKEKAREDAARERA---RDREERLAALTAAQQEAME-ELQKKIQL 502
+ A E+ +++++ A EDAAR+RA R E+LAA+ A + E E+ K +
Sbjct: 1828 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1887
Query: 503 KHDESIRRHME----QIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSE 558
+E +RR E Q + +E+AA+ + K + E ++Q L +
Sbjct: 1888 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947
Query: 559 VYLFSHVKGRK--HQQAVRENTSIQ---GRELSDEEVEHLSLKKYIIDIVVESTAPAE-- 611
+ + K ++A ++ GR S+ E S ++ ++ + AE
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Query: 612 -ALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQV 670
++ EER + A++ AR A E ++ K + + Q A+ L
Sbjct: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
Query: 671 QVQDSGSWANNKVS--ALDRTLGEITRILEKE-NVADQIAFQAAGGLTALEHILQAVVPA 727
+ A K A+ + E+ + L++E +V DQ+ +A A E +A V A
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2127
Score = 76.3 bits (186), Expect = 2e-13
Identities = 86/362 (23%), Positives = 160/362 (44%), Gaps = 32/362 (8%)
Query: 296 ESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRM--MEEKLL 353
E++ + + Q +A++LR ++++E K Q +E V+ E +++R + +EE L
Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570
Query: 354 HAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNE----- 408
AE QA V++A++ + + E Q+KR K + E+ L E
Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630
Query: 409 --LQEERQRR----QEEKQARDEAVQERKR----ALEAER-QARVEELLMKRKEQEARIE 457
L+EE +RR E ++AR+EA +E +R A EA R + + EE+ ++ +A E
Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690
Query: 458 QQRQEKEK-AREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIE 516
+Q++E E+ AR E R+ LA +Q + E + +L ++ + R + E
Sbjct: 1691 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1750
Query: 517 QRKEKAAELSSGRHANTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRE 576
Q +++ L A T ++ + L V EV L S + +
Sbjct: 1751 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE------- 1803
Query: 577 NTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFR 636
+ R S++ + L + + E A AL EE ++ ++ A++ AR
Sbjct: 1804 ----ESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL--AEEAKRQRQLAEEDAARQRAE 1857
Query: 637 AK 638
A+
Sbjct: 1858 AE 1859
Score = 73.2 bits (178), Expect = 1e-12
Identities = 117/531 (22%), Positives = 224/531 (42%), Gaps = 80/531 (15%)
Query: 107 DVKNSGSIRDNYVRTSEISAVHIDTE------CVSVMLQAGTPPLQVNEEKFPAEKARIE 160
+ + G + VR E++ ++ + L A +++ E E+ R
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
Query: 161 NEMDPSDISNSMAEVLAKKEELADRLEK--ANEEAIASAIAEEEQLTREIEAEENNDINI 218
E + + + A K++EL L K A E + ++ A E+ +R + +
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
Query: 219 ETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGDIVEEEPARPPGHG 278
E + + A E+ RQ + EE+ AR
Sbjct: 1819 EAGRFRELAEEAARLRAL----------------AEEAKRQR----QLAEEDAARQRAEA 1858
Query: 279 IH-MHEKLSS---PSRKRTIAE-SKKKHEEKQMKAQQL-------REKLREEKTLKLQKL 326
+ EKL++ +R +T AE + K+ E + + ++L R +L E+ +
Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1918
Query: 327 LEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVN------EI 380
ER +RK + L++++ ++E+ L +R+V+ + + KA E+A E+
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQ---RRQVEEEILALKASFEKAAAGKAELELEL 1975
Query: 381 AFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQ-------ARDEAVQERKRA 433
I + R ++L+ QR +EER RR+E ++ A +EA ++RK A
Sbjct: 1976 GRIRSNAEDTLRSKEQAELEAARQRQLAAEEER-RRREAEERVQKSLAAEEEAARQRKAA 2034
Query: 434 LEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDR---EERLAALTAAQ 489
LE VE L K K +EAR ++R E+E AR+ A+E A+ R EE+ A Q
Sbjct: 2035 LE-----EVERL--KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2087
Query: 490 QEAMEELQKKIQLKHD---------ESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLT 540
+E +ELQ+ +Q + E+ RR E+ E+ + +A ++ + A +L
Sbjct: 2088 KE--QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLK 2145
Query: 541 PYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVE 591
++ + ++E L + ++A E +++ ++ +D E+E
Sbjct: 2146 QSAEEQAQARAQAQAAAE-KLRKEAEQEAARRAQAEQAALRQKQAADAEME 2195
Score = 67.0 bits (162), Expect = 1e-10
Identities = 95/456 (20%), Positives = 186/456 (40%), Gaps = 65/456 (14%)
Query: 146 QVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEE--Q 203
QV +E E + + + + + A+ E A + + EE + + EE +
Sbjct: 2210 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2269
Query: 204 LTREIEAEENNDINIETDNDSDF----SASMGSGSVSFCGMSMDWNDVLADYE-ARESWR 258
L IEAE I + DN F + M + +S+ + + A E
Sbjct: 2270 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2329
Query: 259 QNTSWGDIVEEEPARPPGHGIHMHEKLSSPSRKRTIAE--SKKKHEEKQMKAQQLREKLR 316
Q + + + +E + + + +++ +A+ +++ E+K+ AQQL E+
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEE-- 2387
Query: 317 EEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQE---- 372
T Q+ LE E+ R+ + +R ++ ++ A+ + E Q K+A+E
Sbjct: 2388 ---TQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2443
Query: 373 ----EEAKVNEIAFINTLEAQNKRHD-----VLSKLKEYEQRLNELQEER---QRRQEEK 420
E A ++ + TLE Q ++ D + + E E+ +LQ+E Q + EE
Sbjct: 2444 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503
Query: 421 QA--------------------------RDEAVQERKRALEAERQARVEELLMKRKEQEA 454
Q R+ +++ K LE Q V + R+EQ+
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563
Query: 455 RIEQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEEL------QKKIQLKHDESI 508
+QQ+ E+E+ R A+ E AR R+ +QE +++L Q+++ + ++ +
Sbjct: 2564 --QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2621
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYER 544
R ++ +E++ A S A+ A K P R
Sbjct: 2622 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR 2657
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/383 (22%), Positives = 162/383 (42%), Gaps = 52/383 (13%)
Query: 283 EKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKWKEE--L 340
E ++SP++K + + ++ + LR E TL Q + + +R+ +EE L
Sbjct: 1321 EPVASPAKKPKVQSGSESVIQEYV---DLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1377
Query: 341 LDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKRHDVLSKLK 400
+Q+R E+L E E Q Q AQ + AQ +R + K
Sbjct: 1378 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAK--------------AQAER-----EAK 1418
Query: 401 EYEQRLNELQEERQRR----QEEKQARDEAVQERKRALEAE-----RQARVEELLMKRKE 451
E +QR+ E R+ Q++K++ E +Q+ +++ EAE RQA E R E
Sbjct: 1419 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478
Query: 452 QEARI---EQQRQEKEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKHDESI 508
+E R+ + + E+++ + + R R E A QE E L++++Q DES
Sbjct: 1479 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ---DESQ 1535
Query: 509 RRHMEQIEQRKEKAAELSSGRHANTDYAP----KLTPYERKKQCSLCNVLISSEVYLFSH 564
R+ ++E AE + R +L E +++ V + +V +
Sbjct: 1536 RKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALE 1595
Query: 565 VKGRKHQQAVR-------ENTSIQGRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGE 617
R + ++ E T+ R L +E V L++ + + A AE ++
Sbjct: 1596 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-AERRAQQQAEAERAREEA 1654
Query: 618 ERQKNKKKAKKIKA-RMNFRAKE 639
ER+ + + K +A R+ +A+E
Sbjct: 1655 ERELERWQLKANEALRLRLQAEE 1677
Score = 61.2 bits (147), Expect = 5e-09
Identities = 142/650 (21%), Positives = 247/650 (38%), Gaps = 143/650 (22%)
Query: 145 LQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANEEAIASAIAEEEQL 204
L+ + EK A KA +E E+ I ++ + L KE+ LE A + +A AEEE+
Sbjct: 1957 LKASFEKAAAGKAELELEL--GRIRSNAEDTLRSKEQA--ELEAARQRQLA---AEEERR 2009
Query: 205 TREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWG 264
RE E + E + A++ + + A E R+
Sbjct: 2010 RREAEERVQKSLAAEEEAARQRKAALE-----------EVERLKAKVEEARRLRERA--- 2055
Query: 265 DIVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKAQQLREKLREEKTLKLQ 324
E+E AR + ++KR AE K Q K Q+L++ L++E+++ Q
Sbjct: 2056 ---EQESAR-------QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105
Query: 325 ---------KLLEREKDVRKWKEELLDQRRRMMEEK-----------------LLHAEFK 358
+ E ++ R E Q RR +EE AE
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2165
Query: 359 REVQLQAIVKKAQEEEAKVNEIAFINTLEAQNKR--HDVLSKLKEYEQRLNELQEERQRR 416
R+ Q ++AQ E+A + + + ++K+ L + + EQ L L+ + +
Sbjct: 2166 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225
Query: 417 QEEKQARDEAVQERK-RALEAERQ----------------------ARVEE----LLMKR 449
+K DE +Q K A EA RQ AR+E L+++
Sbjct: 2226 DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2285
Query: 450 KEQEARIEQQRQEKEK----------------------AREDAARERARD----REERLA 483
K+ R Q+ EK K A ED A++RA +E+ A
Sbjct: 2286 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2345
Query: 484 ALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYE 543
A + +A EL ++ + E RR E EQ ++ AE + G + E
Sbjct: 2346 VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLE-------AE 2398
Query: 544 RKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
R++Q + + L V QA E + + R+ ++E E L +
Sbjct: 2399 RQRQLEMS----AEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2454
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLA 663
V E +RQ++ A++++ + +E E L + +AKL +L
Sbjct: 2455 VTLVQTLEI-----QRQQSDHDAERLREAIAELEREKEKLQQ----------EAKLLQLK 2499
Query: 664 KDLLKQVQ----VQDSGSWANNKVSALDRTLGEITRILEKENVADQIAFQ 709
+ ++ VQ +Q++ + + +S D L + R +E+E + FQ
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLL-QRERFIEQEKAKLEQLFQ 2548
Score = 61.2 bits (147), Expect = 5e-09
Identities = 79/349 (22%), Positives = 160/349 (45%), Gaps = 45/349 (12%)
Query: 173 AEVLAKKEELAD---RLEKANEEAIASAIAEEEQ-LTREIEAEENNDINIETDNDSDFSA 228
AE+L +++ELA R + ++E +A +AEE Q R +EAE + + + +
Sbjct: 2356 AELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAER---- 2411
Query: 229 SMGSGSVSFCGMSMDWNDVLADYEARESWRQNTSWGD-------IVEEEPARPPGHGIHM 281
+ M A+ +A+ +Q G+ +E+ I
Sbjct: 2412 ------LKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQR 2465
Query: 282 HEKLSSPSRKR-TIAESKKKHEEKQMKAQQLREKLREEKTLKLQKLLEREKDVRKW---- 336
+ R R IAE +++ E+ Q +A+ L+ K E +T++ ++LL+ + +++
Sbjct: 2466 QQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSE 2525
Query: 337 KEELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQ---EEEAKVNEIAFINTLEAQNKRH 393
K+ LL + R + +EK K E Q V KAQ EE+ + + + + +R
Sbjct: 2526 KDSLLQRERFIEQEKA-----KLEQLFQDEVAKAQQLREEQQRQQQ-------QMEQERQ 2573
Query: 394 DVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQE 453
+++ ++E +R +E +E +R+QEE Q ++ ++++ L E Q E+L + E++
Sbjct: 2574 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL--LEEQ 2631
Query: 454 ARIEQQRQEKEKAREDAARERARDREERL--AALTAAQQEAMEELQKKI 500
R E+ A + AA + + + L A A + + + L++K+
Sbjct: 2632 HRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKV 2680
Score = 53.5 bits (127), Expect = 1e-06
Identities = 92/370 (24%), Positives = 159/370 (42%), Gaps = 47/370 (12%)
Query: 315 LREEKTLKLQKLLEREKDVRKWKEEL----LDQRRRMMEEKLLHAEFKREVQLQAIVKKA 370
LR E L L KL + + E+L L R E++L A ++ + QA+
Sbjct: 1090 LRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1149
Query: 371 QEEEAKVNEIAFINT-LEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQE 429
E EA + + EAQ D L ++ + E+ E Q+R E+ E +E
Sbjct: 1150 PELEATKASLKKLRAQAEAQQPTFDAL---RDELRGAQEVGERLQQRHGERDVEVERWRE 1206
Query: 430 RKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKARE-DAARERARDREERLAALTAA 488
R L QA + + ++++E E Q R +E A A + AR R+E++ A+ A
Sbjct: 1207 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1266
Query: 489 QQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYERKKQ- 547
+A+ E ++ Q +E I RH E++E+ + A + +A DY +L Y+ + +
Sbjct: 1267 DSQAVREQLRQEQALLEE-IERHGEKVEECQRFAKQYI---NAIKDYELQLVTYKAQLEP 1322
Query: 548 ----CSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIV 603
V SE + +V R H + TS +YI I
Sbjct: 1323 VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTS-----------------QYIKFI- 1364
Query: 604 VESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQ--R 661
+E L+ EE + + A++ +A R E E+ +E + +++ +AK Q R
Sbjct: 1365 ------SETLRRMEEEE---RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1415
Query: 662 LAKDLLKQVQ 671
AK+L +++Q
Sbjct: 1416 EAKELQQRMQ 1425
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 76.6 bits (187), Expect = 1e-13
Identities = 106/456 (23%), Positives = 204/456 (44%), Gaps = 71/456 (15%)
Query: 302 EEKQMKAQQLREKLREEKTLKLQKLLEREK---DVRKWKEELLDQRRRMMEEKLLHAEFK 358
E+KQ K QL L EEK + + ER++ + R+ KE R +EE L E K
Sbjct: 1447 EKKQRKFDQL---LAEEKNISSKYADERDRAEAEARE-KETKALSLARALEEAL---EAK 1499
Query: 359 REVQLQAIVKKAQEEE-AKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQ 417
E++ + KA+ E+ + N E + + + ++++E + +L EL++E Q +
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 418 EEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARD 477
+ K + +Q K E + QAR E+ +E+ ++++Q E E ED ++R
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQ----NEEKRRQLQRQLHEYETELEDERKQR--- 1612
Query: 478 REERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELS------SGRHA 531
AL AA ++ +E K ++L+ D +I+ E I+Q ++ A++ A
Sbjct: 1613 ------ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 532 NTDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVREN------TSIQGR-- 583
+ D KK SL L+ + L + + RK +E +S+ GR
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNA 1726
Query: 584 -------------ELSDEEVEHLSLKKYIIDIVVESTAPAEAL------------KDGEE 618
+L +E E + + D V ++T AE L K+
Sbjct: 1727 LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786
Query: 619 RQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKLQRLAKDLLKQVQVQDSGSW 678
RQ+ +++ K+++++++ E E +++K + + +AK+ +L + + ++ + + +
Sbjct: 1787 RQQLERQNKELRSKLH----EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA--- 1839
Query: 679 ANNKVSALDRTLGEITRILEKE-NVADQIAFQAAGG 713
A + D+ L EI +E E +A+Q QA G
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1875
Score = 73.2 bits (178), Expect = 1e-12
Identities = 140/693 (20%), Positives = 275/693 (39%), Gaps = 113/693 (16%)
Query: 138 LQAGTPPLQVNEEKFPAEKARIENEMDPSDISNSMAEVLAKKEELADRLEKANE-----E 192
+QA LQ +E+ + + ENE+ ++ +++ +K L ++L+ E E
Sbjct: 854 MQAKEDELQKTKER----QQKAENEL--KELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 193 AIASAIAEEEQLTREIEAEENNDINIETDNDSDFSASMGSGSVSFCGMSMDWNDVLADYE 252
+ +A ++Q EI E + E D A M+ D+ E
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK-------MAQQMLDLEEQLE 960
Query: 253 ARESWRQNTSWGDIVEEEPARPPGHGIH-MHEKLSSPSRKRTIAESK------------- 298
E+ RQ + E + I M ++ + S++R + E +
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020
Query: 299 --------KKHEEKQMKAQQLREKLREEKTLKLQKLLER-EKDVRKWKEELLDQRRRMME 349
K E + ++R K E+ +L+KL + E D + E++ D + ++ E
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 350 EKLLHAEFKREVQLQAIVKKAQEEEA-KVNEIAFINTLE-------------------AQ 389
K+ A K+E +LQA + + +E A K N + I LE A+
Sbjct: 1081 LKMQLA--KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 390 NKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQERKRALEAE---RQARVEELL 446
++ D+ +L+ + L + + +QE + R++ V K+AL+ E +A+V+E+
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 447 MKRKEQEARIEQQRQE--KEKAREDAARERARDREERLAALTAAQQEAMEELQKKIQLKH 504
K + + +Q ++ + KA D ++ LA +A +E++ K + K
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHK-KKKL 1257
Query: 505 DESIRRHMEQIEQRKEKAAELSSGRHANTDYAPKLTPYER----------KKQCSLCNVL 554
+ ++ + + AEL+ H + +T K SL + L
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 555 ISSEVYLFSHVKGR-----KHQQAVRENTSIQGRELSDEEVEHLSLKKYIIDIVVEST-- 607
++ L + + K +Q E S+Q +L +E +L+++I + ++ +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-QLDEEMEAKQNLERHISTLNIQLSDS 1376
Query: 608 --------APAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSDSPYKAKL 659
+ EAL++G++R +K+ + + + +A Y+ L +TKN + +L
Sbjct: 1377 KKKLQDFASTVEALEEGKKR--FQKEIENLTQQYEEKAAAYDKLEKTKNR-----LQQEL 1429
Query: 660 QRLAKDLLKQVQVQDSGSWANNKVSALDRTLGEITRILEK--------ENVADQIAFQAA 711
L DL Q Q+ + K D+ L E I K E A + +A
Sbjct: 1430 DDLVVDLDNQRQLVSN---LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 712 GGLTALEHILQAVVPATNVNTVLRIPPKSLCNA 744
ALE L+A N +L+ + L ++
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519
Score = 67.0 bits (162), Expect = 1e-10
Identities = 77/364 (21%), Positives = 168/364 (46%), Gaps = 48/364 (13%)
Query: 312 REKLREEKTLKLQKLLEREKDVRKWKEELLDQRRRMMEEK-LLHAEFKREVQLQAIVKKA 370
+E+ + K +LQK ER++ +EL + ++ EEK LL + + E +L A
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY-----A 904
Query: 371 QEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQ------EEKQARD 424
+ EE +V A E + H++ ++L+E E R +LQ ER++ EE+ +
Sbjct: 905 EAEEMRVRLAA--KKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 425 EAVQERKRALEAERQARVEEL---LMKRKEQEARIEQQRQEKEKAREDAARERARDRE-- 479
EA +++ + + +A++++L ++ +Q ++ ++R+ E+ D A + E
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 480 ERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAA-----ELSSGRHANTD 534
+ L L + + EL+ ++LK +E R+ +E+++++ E A +++ + +
Sbjct: 1023 KNLTKLKNKHESMISELE--VRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 535 YAPKLTPYERKKQCSLC---------NVLISSEVYLFSHVKGRKH----QQAVRENTSIQ 581
+L E + Q +L N + L H+ + ++A R Q
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 582 GRELSDEEVEHLSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYE 641
R+L +E L K ++ ++STA + L R K +++ +K ++ + +E
Sbjct: 1141 KRDLGEE----LEALKTELEDTLDSTATQQEL-----RAKREQEVTVLKKALDEETRSHE 1191
Query: 642 SLME 645
+ ++
Sbjct: 1192 AQVQ 1195
Score = 63.2 bits (152), Expect = 1e-09
Identities = 81/357 (22%), Positives = 159/357 (44%), Gaps = 40/357 (11%)
Query: 371 QEEEAKVNEIAFINTLEAQNKRHDVLSKLKEYEQRLNELQEERQRRQEEKQARDEAVQE- 429
QEEE + E T E Q K + +LKE EQ+ ++L EE+ QE+ QA E E
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAEN---ELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 430 ---------RKRALEA---ERQARVEELLMKRKEQEARIEQQRQEKEKAREDAARERARD 477
+K+ LE E +AR+EE + ++ +A ++ Q+ E E A
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 478 REERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHANTDYAP 537
++ +L +TA + +++L+ +I + D++ + E+ + +E+ ++L++ + A
Sbjct: 967 QKLQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKER-KLLEERISDLTTNLAEEEEKAK 1023
Query: 538 KLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEHLSLKK 597
LT + K + +++ EV L K R+ + ++ ++G + SD + L+
Sbjct: 1024 NLTKLKNKHE----SMISELEVRLKKEEKSRQELEKLKR--KLEG-DASDFHEQIADLQA 1076
Query: 598 YIIDIVVESTAPAEALK------DGEERQKNK--KKAKKIKARMNFRAKEYESLMETKNS 649
I ++ ++ E L+ D E QKN KK ++++ ++ ++ +S +N
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNK 1136
Query: 650 GS------DSPYKAKLQRLAKDLLKQVQVQDSGSWANNKVSALDRTLGEITRILEKE 700
+A L L Q+ + +V+ L + L E TR E +
Sbjct: 1137 AEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193
Score = 60.1 bits (144), Expect = 1e-08
Identities = 60/272 (22%), Positives = 125/272 (45%), Gaps = 48/272 (17%)
Query: 293 TIAESKKKHEEKQMKAQQLREKL------REEKTLKLQKLLEREKDVRKWKEELLDQRRR 346
T E++KK + + QL+E L R++ L+ ++L E + L D++RR
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 347 M------MEEKLLHAEFKREVQLQAIVKKAQEEEAKVNEIAFINT-----------LEAQ 389
+ +EE+L + E + K Q+ E NE+A + LE Q
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 390 NKR-----HD----VLSKLKE----YEQRLNELQEERQRRQEEKQARDEAVQERKRALEA 436
NK H+ V SK K E ++ +L+E+ ++ EKQA ++++++ +
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK---- 1849
Query: 437 ERQARVEELLMKRKEQEARIEQQRQEKEK--AREDAARERARDREERLAALTAAQQEAME 494
+++E+L++ +++ EQ +++ EK AR + + + EE + A +++
Sbjct: 1850 ----KLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1905
Query: 495 ELQKKIQLKHDESIRRHMEQIEQRKEKAAELS 526
EL + + +E++ R + ++ + + E S
Sbjct: 1906 ELDEATE--SNEAMGREVNALKSKLRRGNETS 1935
Score = 45.4 bits (106), Expect = 3e-04
Identities = 77/322 (23%), Positives = 133/322 (41%), Gaps = 42/322 (13%)
Query: 415 RRQEEKQARDEAVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKARE--DAAR 472
R++EE QA+++ +Q+ K ERQ + E L KE E + Q +EK +E A
Sbjct: 849 RQEEEMQAKEDELQKTK-----ERQQKAENEL---KELEQKHSQLTEEKNLLQEQLQAET 900
Query: 473 ERARDREERLAALTAAQQEAMEELQKKIQLKHDESIRRHMEQIEQRKEKAAELSSGRHAN 532
E + EE L A +QE +EE+ +++ + +E R + +RK+ A ++
Sbjct: 901 ELYAEAEEMRVRLAAKKQE-LEEILHEMEARLEEEEDRGQQLQAERKKMAQQM------- 952
Query: 533 TDYAPKLTPYERKKQCSLCNVLISSEVYLFSHVKGRKHQQAVRENTSIQGRELSDEEVEH 592
D +L E +Q L +V + +K + + V ++ Q +LS E
Sbjct: 953 LDLEEQLEEEEAARQ-----KLQLEKVTAEAKIKKLEDEILVMDD---QNNKLSK---ER 1001
Query: 593 LSLKKYIIDIVVESTAPAEALKDGEERQKNKKKAKKIKARMNFRAKEYESLMETKNSGSD 652
L++ I D+ L + EE+ KN K K K E E K+
Sbjct: 1002 KLLEERISDLTTN-------LAEEEEKAKNLTKLKN-KHESMISELEVRLKKEEKSRQEL 1053
Query: 653 SPYKAKLQRLAKDLLKQV-----QVQDSGSWANNKVSALDRTLGEITRILEKENVADQIA 707
K KL+ A D +Q+ Q+ + K L L + + ++N A +
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI 1113
Query: 708 FQAAGGLTALEHILQAVVPATN 729
+ G ++ L+ L + A N
Sbjct: 1114 RELEGHISDLQEDLDSERAARN 1135
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.361
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,567,825
Number of Sequences: 37866
Number of extensions: 1992798
Number of successful extensions: 36048
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 622
Number of HSP's successfully gapped in prelim test: 1347
Number of HSP's that attempted gapping in prelim test: 9869
Number of HSP's gapped (non-prelim): 9576
length of query: 1154
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1041
effective length of database: 13,968,660
effective search space: 14541375060
effective search space used: 14541375060
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.