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Search of human proteins with 224809414
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
(361 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1 [... 697 0.0
gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1 [... 697 0.0
gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2 [... 686 0.0
gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3 [... 611 e-175
gi|4759198 homer 1 [Homo sapiens] 329 3e-90
gi|46249351 homer 2 isoform 2 [Homo sapiens] 297 1e-80
gi|46249349 homer 2 isoform 1 [Homo sapiens] 293 2e-79
gi|110349797 homer 2 isoform 4 [Homo sapiens] 240 1e-63
gi|110349794 homer 2 isoform 3 [Homo sapiens] 236 2e-62
gi|56549694 enabled homolog isoform a [Homo sapiens] 80 2e-15
gi|39930375 enabled homolog isoform b [Homo sapiens] 80 2e-15
gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens] 59 5e-09
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 57 2e-08
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 56 6e-08
gi|126723390 ankyrin repeat domain 24 [Homo sapiens] 55 1e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 55 1e-07
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 54 3e-07
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 54 3e-07
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 52 6e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 52 6e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 52 1e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 52 1e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 52 1e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 52 1e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 52 1e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 52 1e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 52 1e-06
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 52 1e-06
gi|7706687 Enah/Vasp-like [Homo sapiens] 52 1e-06
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 52 1e-06
>gi|224809414 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
Length = 361
Score = 697 bits (1799), Expect = 0.0
Identities = 361/361 (100%), Positives = 361/361 (100%)
Query: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
Query: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS
Sbjct: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL
Sbjct: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
Query: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
Query: 361 P 361
P
Sbjct: 361 P 361
>gi|224809408 Homer, neuronal immediate early gene, 3 isoform 1
[Homo sapiens]
Length = 361
Score = 697 bits (1799), Expect = 0.0
Identities = 361/361 (100%), Positives = 361/361 (100%)
Query: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
Query: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS
Sbjct: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL
Sbjct: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
Query: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
Query: 361 P 361
P
Sbjct: 361 P 361
>gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2
[Homo sapiens]
Length = 358
Score = 686 bits (1770), Expect = 0.0
Identities = 358/361 (99%), Positives = 358/361 (99%), Gaps = 3/361 (0%)
Query: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
Query: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS
Sbjct: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQ
Sbjct: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQ-- 298
Query: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 299 -TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 357
Query: 361 P 361
P
Sbjct: 358 P 358
>gi|224809419 Homer, neuronal immediate early gene, 3 isoform 3
[Homo sapiens]
Length = 325
Score = 611 bits (1575), Expect = e-175
Identities = 325/361 (90%), Positives = 325/361 (90%), Gaps = 36/361 (9%)
Query: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII
Sbjct: 1 MSTAREQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAII 60
Query: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKS 120
NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQ
Sbjct: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQ------------------- 101
Query: 121 QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 180
VPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV
Sbjct: 102 -----------------VPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV 144
Query: 181 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 240
GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS
Sbjct: 145 GEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS 204
Query: 241 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 300
EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL
Sbjct: 205 EVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDL 264
Query: 301 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA
Sbjct: 265 ETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 324
Query: 361 P 361
P
Sbjct: 325 P 325
>gi|4759198 homer 1 [Homo sapiens]
Length = 354
Score = 329 bits (843), Expect = 3e-90
Identities = 185/359 (51%), Positives = 240/359 (66%), Gaps = 11/359 (3%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
EQPIFSTRAHVFQIDP TK+NW+P KHA+TVSYFYD+TRNVYRIIS+ G+KAIINST+T
Sbjct: 3 EQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTIT 62
Query: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
PNMTFTKTSQKFGQWADSRANTVYGLGF+SE HL++FAEKFQE KEAARLA+EKSQ+ E
Sbjct: 63 PNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKME 122
Query: 126 LTSPALGLASHQVPPSPLV--SANGPGEEKL--FRSQSADAPGPTERERLKKMLSEGSVG 181
LTS ++ SPL S NG +E+ S PT+ S S
Sbjct: 123 LTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQN---ALPFSHSSAI 179
Query: 182 EVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE 241
WEAE L+ +N KL AL E+ A QW+QQL A + EAERL +RV ELE ++
Sbjct: 180 SKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQA 239
Query: 242 VTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLE 301
K L Q++++LE ++ K++EI+ LK + RE E +R+ QK+Q++E
Sbjct: 240 NAVHTHKTEL--NQTIQELEETLKLKEEEIERLKQEIDNARELQE--QRDSLTQKLQEVE 295
Query: 302 TRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEAA 360
RN +LE QL +E+ LE+++ E+E R + ++LD +FEL+ELR+ LA+L E +
Sbjct: 296 IRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS 354
>gi|46249351 homer 2 isoform 2 [Homo sapiens]
Length = 354
Score = 297 bits (760), Expect = 1e-80
Identities = 161/352 (45%), Positives = 236/352 (67%), Gaps = 5/352 (1%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
Query: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
Query: 126 LTSPALGLASHQVPPSPLVSA-NGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQ 184
+S + + P S S+ NG +EK + A+ +E ++LK L++ + +
Sbjct: 123 TSSNHSQESGRETPSSTQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKK 182
Query: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
WE E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 183 WEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINR 241
Query: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRN 304
EK + +E+LEA ++ K+ E++ L+ Q+ + + +E E +K++ E N
Sbjct: 242 EKEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM--SECEYVSEKLEAAERDN 298
Query: 305 AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 299 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 350
>gi|46249349 homer 2 isoform 1 [Homo sapiens]
Length = 343
Score = 293 bits (749), Expect = 2e-79
Identities = 161/351 (45%), Positives = 234/351 (66%), Gaps = 14/351 (3%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
Query: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
Query: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
+S +H S S NG +EK + A+ +E ++LK L++ + +W
Sbjct: 123 TSS------NH----SQASSVNGTDDEKASHAGPANTHLKSENDKLKIALTQSAANVKKW 172
Query: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
E E L++SN +L AL+E+ A+ QW++Q R E +RLR ++ ELE Q SE+
Sbjct: 173 EIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQ-CSEINRE 231
Query: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNA 305
EK + +E+LEA ++ K+ E++ L+ Q+ + + +E E +K++ E N
Sbjct: 232 KEK-NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLM--SECEYVSEKLEAAERDNQ 288
Query: 306 ELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 289 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 339
>gi|110349797 homer 2 isoform 4 [Homo sapiens]
Length = 299
Score = 240 bits (613), Expect = 1e-63
Identities = 145/352 (41%), Positives = 206/352 (58%), Gaps = 60/352 (17%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
Query: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
Query: 126 LTSPALGLASHQVPPSPLVSA-NGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQ 184
+S + + P S S+ NG +EK A GP
Sbjct: 123 TSSNHSQESGRETPSSTQASSVNGTDDEK------ASHAGPANTH--------------- 161
Query: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
L+ N+KL AL + +AA + ++ ++ + +L++R+ ELEA+ + T
Sbjct: 162 -------LKSENDKLKIALTQ---SAANVKNEINREKEKNTQLKRRIEELEAELREKETE 211
Query: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRN 304
+ ++ + + I L S+ E LEAAER+ N
Sbjct: 212 LKD----------------LRKQSEIIPQLMSECEYVSEKLEAAERD------------N 243
Query: 305 AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 244 QNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 295
>gi|110349794 homer 2 isoform 3 [Homo sapiens]
Length = 288
Score = 236 bits (602), Expect = 2e-62
Identities = 145/351 (41%), Positives = 204/351 (58%), Gaps = 69/351 (19%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVT 65
EQPIF+TRAHVFQIDP TK+NW+PA K A+TVSYFYD TRN YRIIS+ GAK IINST+T
Sbjct: 3 EQPIFTTRAHVFQIDPNTKKNWMPASKQAVTVSYFYDVTRNSYRIISVDGAKVIINSTIT 62
Query: 66 PNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGE 125
PNMTFTKTSQKFGQWADSRANTV+GLGF+SEQ LT+FAEKFQEVKEAA++A++K+Q+ E
Sbjct: 63 PNMTFTKTSQKFGQWADSRANTVFGLGFSSEQQLTKFAEKFQEVKEAAKIAKDKTQEKIE 122
Query: 126 LTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQW 185
+S +H S S NG +EK A GP
Sbjct: 123 TSS------NH----SQASSVNGTDDEK------ASHAGPANTH---------------- 150
Query: 186 EAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPT 245
L+ N+KL AL + +AA + ++ ++ + +L++R+ ELEA+ + T
Sbjct: 151 ------LKSENDKLKIALTQ---SAANVKNEINREKEKNTQLKRRIEELEAELREKETEL 201
Query: 246 GEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNA 305
+ ++ + + I L S+ E LEAAER+ N
Sbjct: 202 KD----------------LRKQSEIIPQLMSECEYVSEKLEAAERD------------NQ 233
Query: 306 ELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
LE ++R+++ +EE++ + + E+ ++LD + +L + R GL++L
Sbjct: 234 NLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRGLSKL 284
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 80.5 bits (197), Expect = 2e-15
Identities = 88/316 (27%), Positives = 126/316 (39%), Gaps = 64/316 (20%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHA--LTVSYFYDATRNVYRIIS--IGGAKAIIN 61
EQ I RA V D A K+ W+PAG V ++ N +R++ I + +IN
Sbjct: 3 EQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVIN 61
Query: 62 STVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQ 121
+ + + + +Q F QW D+R VYGL F S++ FA E SQ
Sbjct: 62 CAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEVL-----NSQ 114
Query: 122 DGGELTSPALGLASHQVPPSPLVSANGPGEEKL----FRSQSADAPGPTERERLKKMLSE 177
+ T P L + Q+P NGP +E+L + Q ERERL+
Sbjct: 115 E----TGPTLPRQNSQLPAQ---VQNGPSQEELEIQRRQLQEQQRQKELERERLE----- 162
Query: 178 GSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQ 237
RE R++LE +R E ERL Q E E Q
Sbjct: 163 --------------------------RERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 238 AASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKV 297
+E L + + LE+ E L D+E Q + RE LE ERE +++
Sbjct: 197 ERERQERLERQERLERQERLERQERL----DRERQERQE-----RERLERLERERQERER 247
Query: 298 QD-LETRNAELEHQLR 312
Q+ LE E E + R
Sbjct: 248 QEQLEREQLEWERERR 263
Score = 30.8 bits (68), Expect = 2.0
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 3/58 (5%)
Query: 277 QTGGPREALEAAERE-ETQQKVQDLETRNAELEHQLRA-MERS-LEEARAERERARAE 331
Q G +E LE R+ + QQ+ ++LE E E R +ER LE R ERER E
Sbjct: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQE 189
Score = 30.0 bits (66), Expect = 3.4
Identities = 34/129 (26%), Positives = 54/129 (41%), Gaps = 22/129 (17%)
Query: 201 GALREANAAAAQWRQQLEAQRAE--AERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE 258
G+ +AN A+ LE ++ L ++ ++L AQ + G S E
Sbjct: 92 GSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQN-------------GPSQE 138
Query: 259 QLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSL 318
+LE + +++Q + Q RE LE E + + + LE E E R + L
Sbjct: 139 ELEI----QRRQLQEQQRQKELERERLERERMERERLERERLERERLERE---RLEQEQL 191
Query: 319 EEARAERER 327
E R ERER
Sbjct: 192 ERERQERER 200
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 80.5 bits (197), Expect = 2e-15
Identities = 88/316 (27%), Positives = 126/316 (39%), Gaps = 64/316 (20%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHA--LTVSYFYDATRNVYRIIS--IGGAKAIIN 61
EQ I RA V D A K+ W+PAG V ++ N +R++ I + +IN
Sbjct: 3 EQSICQARAAVMVYDDANKK-WVPAGGSTGFSRVHIYHHTGNNTFRVVGRKIQDHQVVIN 61
Query: 62 STVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQ 121
+ + + + +Q F QW D+R VYGL F S++ FA E SQ
Sbjct: 62 CAIPKGLKYNQATQTFHQWRDAR--QVYGLNFGSKEDANVFASAMMHALEVL-----NSQ 114
Query: 122 DGGELTSPALGLASHQVPPSPLVSANGPGEEKL----FRSQSADAPGPTERERLKKMLSE 177
+ T P L + Q+P NGP +E+L + Q ERERL+
Sbjct: 115 E----TGPTLPRQNSQLPAQ---VQNGPSQEELEIQRRQLQEQQRQKELERERLE----- 162
Query: 178 GSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQ 237
RE R++LE +R E ERL Q E E Q
Sbjct: 163 --------------------------RERMERERLERERLERERLERERLEQEQLERERQ 196
Query: 238 AASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKV 297
+E L + + LE+ E L D+E Q + RE LE ERE +++
Sbjct: 197 ERERQERLERQERLERQERLERQERL----DRERQERQE-----RERLERLERERQERER 247
Query: 298 QD-LETRNAELEHQLR 312
Q+ LE E E + R
Sbjct: 248 QEQLEREQLEWERERR 263
Score = 30.8 bits (68), Expect = 2.0
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 3/58 (5%)
Query: 277 QTGGPREALEAAERE-ETQQKVQDLETRNAELEHQLRA-MERS-LEEARAERERARAE 331
Q G +E LE R+ + QQ+ ++LE E E R +ER LE R ERER E
Sbjct: 132 QNGPSQEELEIQRRQLQEQQRQKELERERLERERMERERLERERLERERLERERLEQE 189
Score = 30.0 bits (66), Expect = 3.4
Identities = 34/129 (26%), Positives = 54/129 (41%), Gaps = 22/129 (17%)
Query: 201 GALREANAAAAQWRQQLEAQRAE--AERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE 258
G+ +AN A+ LE ++ L ++ ++L AQ + G S E
Sbjct: 92 GSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQN-------------GPSQE 138
Query: 259 QLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSL 318
+LE + +++Q + Q RE LE E + + + LE E E R + L
Sbjct: 139 ELEI----QRRQLQEQQRQKELERERLERERMERERLERERLERERLERE---RLEQEQL 191
Query: 319 EEARAERER 327
E R ERER
Sbjct: 192 ERERQERER 200
>gi|4507869 vasodilator-stimulated phosphoprotein [Homo sapiens]
Length = 380
Score = 59.3 bits (142), Expect = 5e-09
Identities = 50/168 (29%), Positives = 74/168 (44%), Gaps = 26/168 (15%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPAGKHALT---VSYFYDATRNVYRIISIG---GAKAI 59
E I S+RA V D KR W+PAG V +++ T N +R++ + +
Sbjct: 3 ETVICSSRATVMLYDDGNKR-WLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVV 61
Query: 60 INSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREK 119
IN + + + + + F QW D+R V+GL F S++ QFA EA
Sbjct: 62 INCAIVRGVKYNQATPNFHQWRDAR--QVWGLNFGSKEDAAQFAAGMASALEAL------ 113
Query: 120 SQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
+ GG PA L + VP NGP E++ Q PGP+E
Sbjct: 114 -EGGGPPPPPA--LPTWSVP-------NGPSPEEV-EQQKRQQPGPSE 150
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 57.4 bits (137), Expect = 2e-08
Identities = 69/266 (25%), Positives = 99/266 (37%), Gaps = 24/266 (9%)
Query: 96 EQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLF 155
EQ + + K QE A RE Q E+ + L + L +GP
Sbjct: 423 EQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAG--- 479
Query: 156 RSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ 215
S D+ E +RL + L+EG G E E Q +L L+EA A
Sbjct: 480 -SPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATAS 538
Query: 216 QLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
Q A ++ E R ELEAQ +S + +G + + E +A E +
Sbjct: 539 QTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMG 598
Query: 276 SQTGGPREAL----EAAEREETQQ-----------KVQDLETRNAELEHQLRAMERSL-- 318
GGP+EA AA RE+ +Q + L+ N L + +E L
Sbjct: 599 PPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQ 658
Query: 319 ---EEARAERERARAEVGRAAQLLDV 341
+ R E ER E AQL D+
Sbjct: 659 EQESKQRLEGERRETESNWEAQLADI 684
Score = 42.4 bits (98), Expect = 7e-04
Identities = 61/215 (28%), Positives = 95/215 (44%), Gaps = 28/215 (13%)
Query: 148 GPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREAN 207
GP E +L + +A RE+L++ S G+ E LQ+ N +L+
Sbjct: 603 GPQEAQLRKEVAA------LREQLEQAHSHRPSGK---EEALCQLQEENRRLSREQERLE 653
Query: 208 AAAAQWRQQLEAQRAEAERLRQRVAELEAQAA---SEVTPTGEKEGLGQGQSLEQLEALV 264
A AQ +Q QR E ER R+ + EAQ A S V G Q + + E L
Sbjct: 654 AELAQ--EQESKQRLEGER-RETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELE 710
Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAME------RSL 318
++ QTL ++ P + A R + + LE ++A LE ++RA + +
Sbjct: 711 SLRNVGTQTLPAR---PLDHQWKARRLQKMEASARLELQSA-LEAEIRAKQGLQERLTQV 766
Query: 319 EEARAERERARAEVGRAAQLLDVSLFELSELREGL 353
+EA+ + ER E + +Q L EL+ LRE L
Sbjct: 767 QEAQLQAERRLQEAEKQSQALQQ---ELAMLREEL 798
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 55.8 bits (133), Expect = 6e-08
Identities = 54/212 (25%), Positives = 92/212 (43%), Gaps = 45/212 (21%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNK----------LA 200
EE+L R Q + E+ +K+ + E Q +AE ++ + L
Sbjct: 344 EEELLRLQQL------QEEKERKLQELELLQEAQRQAERLLQEEEERRRSQHRELQQALE 397
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAAS-------EVTPTGEKEGLGQ 253
G LREA A A + ++E + EA R RQR+ ELE EV ++E +
Sbjct: 398 GQLREAEQARASMQAEMELKEEEAARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRI 457
Query: 254 GQSL------EQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAEL 307
Q+ E+L+ L+Q K+++ + + E QQ+ ++L+ A+
Sbjct: 458 AQTRLLEEEEEKLKQLMQLKEEQERYI----------------ERAQQEKEELQQEMAQQ 501
Query: 308 EHQLRAMERSLEEARAERERARAEVGRAAQLL 339
L+ ++ LEE R R+RA +V A + L
Sbjct: 502 SRSLQQAQQQLEEVRQNRQRADEDVEAAQRKL 533
>gi|126723390 ankyrin repeat domain 24 [Homo sapiens]
Length = 1146
Score = 55.1 bits (131), Expect = 1e-07
Identities = 71/233 (30%), Positives = 102/233 (43%), Gaps = 29/233 (12%)
Query: 144 VSANG---PGEEKLFRSQSADAPGPTERERLKKMLSEGSVG-EVQWEAEFFALQDSNNKL 199
VSA G PG E A PG + L +E S +V+ E L+++ L
Sbjct: 687 VSATGVENPGVE-------ATVPGISAGPILHPGAAEASEKLQVELETRIRGLEEA---L 736
Query: 200 AGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQ 259
REA A + EA AEA RLR+RV E E AS G + +LEQ
Sbjct: 737 RQREREAAAELEAALGKCEAAEAEAGRLRERVREAEGSGAS---GGGGGDTTQLRAALEQ 793
Query: 260 LEALVQTKDQEIQTLKSQTGGPREALEA---AEREETQQKVQDLETRNAELE--HQLRAM 314
++ +D ++ L++ + EA + AE E + + + A LE +L +
Sbjct: 794 AREDLRDRDSRLRELEAASACLDEARASRLLAEEEARGLRAELAQREEARLEQSRELEVL 853
Query: 315 ERSLEEARAERERAR---AEVGRAAQLLDVSLFEL----SELREGLARLAEAA 360
L ARA E+ R AE+GRA + + EL E R+GLA L EA+
Sbjct: 854 REQLATARATGEQQRTAAAELGRARDAAEARVAELPAACEEARQGLAELREAS 906
Score = 37.4 bits (85), Expect = 0.021
Identities = 59/239 (24%), Positives = 93/239 (38%), Gaps = 26/239 (10%)
Query: 76 KFGQWADSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLAS 135
+ G+ D+ V L A E+ AE +E EA R + + + L AL L
Sbjct: 873 ELGRARDAAEARVAELPAACEEARQGLAE-LREASEALRQSVVPASEHRRLQEEALELRG 931
Query: 136 HQVPPSPLVSANGPGEEKL---FRSQSADAPGPTERERLKKMLS------EGSVGEV--- 183
V A G +L + + +E ER+ L EG + E+
Sbjct: 932 RAASLEQEVVATGKEAARLRAELERERVCSVALSEHERIVGTLQANVAQLEGQLEELGRR 991
Query: 184 --QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE 241
+ AE F +Q + A A A QQL R EAER RQ A+ AQ A +
Sbjct: 992 HEKTSAEVFQVQREALFMKSERHAAEAQLATAEQQLRGLRTEAERARQ--AQSRAQEALD 1049
Query: 242 VTPTGE-------KEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREET 293
+ KE ++L++ A + T E++ L+ Q ++ L+ A R+ +
Sbjct: 1050 KAKEKDKKITELSKEVFNLKEALKEQPAALAT--PEVEALRDQVKDLQQQLQEAARDHS 1106
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 54.7 bits (130), Expect = 1e-07
Identities = 65/275 (23%), Positives = 104/275 (37%), Gaps = 20/275 (7%)
Query: 74 SQKFGQWADSRANTVYGLGFASEQH------LTQFAEKFQEVKEAARLAREKSQDGGELT 127
SQ+ + D + G A E+ T + E ++ E+ + GG+ +
Sbjct: 1749 SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS 1808
Query: 128 SPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSV----GEV 183
L G E + + A+ E E ++ +EG GE
Sbjct: 1809 GHEDNLQGEAAAGGDQDPGQSDGAEGI-EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEA 1867
Query: 184 QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVT 243
Q E+E ++ + + A+W Q E++ AEA AE EAQ +E
Sbjct: 1868 QPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPE-----AEKEAQPETESV 1922
Query: 244 PTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAE-REETQQKVQDLET 302
E EG + +S E EA Q ++ Q + QT E +E+ E EE Q + +D+E
Sbjct: 1923 EALETEGEDEPES-EGAEA--QEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEA 1979
Query: 303 RNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 337
E+E Q E E E A E+ A +
Sbjct: 1980 LEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEE 2014
Score = 43.9 bits (102), Expect = 2e-04
Identities = 47/198 (23%), Positives = 83/198 (41%), Gaps = 14/198 (7%)
Query: 151 EEKLFRSQSADAPGPTERERLK----KMLSEGSVGEVQWEAEFFALQDSNNKLAGALREA 206
E ++ SQ A+ E E ++ ++ ++ + GE Q E+E ++ ++ A EA
Sbjct: 1957 ESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEA 2016
Query: 207 NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE----VTPTGEKEGL---GQGQSLEQ 259
+ Q +++ EA+ + + E A E P E+E G+ Q E
Sbjct: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEG 2076
Query: 260 LEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
EA +++D + Q + + E +EA E E QK + +E E E + + +E
Sbjct: 2077 -EAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA--PETEGEAQPESEGIE 2133
Query: 320 EARAERERARAEVGRAAQ 337
AE E G AQ
Sbjct: 2134 APEAEGEAQPESEGVEAQ 2151
Score = 38.5 bits (88), Expect = 0.009
Identities = 68/242 (28%), Positives = 99/242 (40%), Gaps = 30/242 (12%)
Query: 108 EVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTE 167
E++EA A+ +S DG E + G + +V + E S +AP E
Sbjct: 2008 EMQEAEEEAQPES-DGVEAQPKSEGEEAQEVEGETQKTEGDAQPE----SDGVEAPEAEE 2062
Query: 168 RERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAE---- 223
++ + GEVQ EAE A +S + A +EA A + +EA AE
Sbjct: 2063 E-------AQEAEGEVQ-EAEGEAHPESEDVDA---QEAEGEAQPESEGVEAPEAEGEAQ 2111
Query: 224 -AERLRQRVAELEAQAASEVTPTGEKEGLGQGQSL------EQLEALVQTKDQEIQTLKS 276
AE + E EAQ SE E EG Q +S + EA +++ E Q +
Sbjct: 2112 KAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEE 2171
Query: 277 QTGGPREALEAAERE-ETQQKVQDLETRNAELEHQ--LRAMERSLEEARAERERARAEVG 333
+ E +EA E E E Q + + +E AE E Q L +E E A+ E E
Sbjct: 2172 EAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETP 2231
Query: 334 RA 335
A
Sbjct: 2232 EA 2233
Score = 34.3 bits (77), Expect = 0.18
Identities = 35/117 (29%), Positives = 49/117 (41%), Gaps = 13/117 (11%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
E + +Q A+ E E ++ +EG E Q E+E ++ + L A
Sbjct: 2160 ESEGIEAQEAEEEAQPELEGVEAPEAEG---EAQPESEGIEAPEAEGEAQPELEGVEAPE 2216
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEG-----LGQGQSLEQLEA 262
A+ Q E + E AE EAQ SE GEK+G LG GQS E E+
Sbjct: 2217 AEEEAQPEPEGVETPE-----AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASES 2268
Score = 33.9 bits (76), Expect = 0.23
Identities = 33/123 (26%), Positives = 51/123 (41%), Gaps = 5/123 (4%)
Query: 234 LEAQAASEVTPTGEKEGLGQGQ----SLEQLEALVQTKDQEIQTLKSQTGGPREALEAAE 289
L A+A + T E E + Q +LEQL ++ +++ K T G EA +
Sbjct: 1262 LNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQ 1321
Query: 290 REETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSEL 349
EET+ + + L+ +LE +E A+ E G Q V L E+ E
Sbjct: 1322 LEETKTE-EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG 1380
Query: 350 REG 352
EG
Sbjct: 1381 PEG 1383
Score = 29.6 bits (65), Expect = 4.4
Identities = 51/212 (24%), Positives = 79/212 (37%), Gaps = 35/212 (16%)
Query: 107 QEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPT 166
QE+ EA+ + SQ+ + G AS P P P E S++ P +
Sbjct: 1408 QELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSET--DPSAS 1465
Query: 167 ERERLKKMLS--EGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ----WRQQL--E 218
ER+ ++ E G E Q + + A +AA W L +
Sbjct: 1466 ERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKK 1525
Query: 219 AQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQ---------TKDQ 269
++A L VAEL A + GL L+Q+ A +Q + +
Sbjct: 1526 TEKAFLAHLASAVAELRA-----------RWGLQDNDLLDQMAAELQQDVAQRLQDSTKR 1574
Query: 270 EIQTLKSQTG-----GPREALEAAEREETQQK 296
E+Q L+ + G PREAL +TQQ+
Sbjct: 1575 ELQKLQGRAGRMVLEPPREALTGELLLQTQQR 1606
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 53.5 bits (127), Expect = 3e-07
Identities = 52/193 (26%), Positives = 91/193 (47%), Gaps = 10/193 (5%)
Query: 172 KKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRV 231
+ L EG + +Q A++ ALQ + + G+L A A R + A +R+
Sbjct: 631 RNQLLEGKLQALQ--ADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAK 688
Query: 232 AELEAQAASEVTPTGEKEGLGQ--GQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAE 289
++AQ A + KEG Q + +EQ + L + + +E++ L+SQ + +E
Sbjct: 689 EAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLT 748
Query: 290 REETQQKV---QDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFEL 346
E+ QQ V D E R EL QL + LE + E +R +A+V + +L +
Sbjct: 749 AEKGQQGVGPPTDNEAR--ELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQ 806
Query: 347 SELREGLARLAEA 359
+++ L+ +AEA
Sbjct: 807 DKVQSQLS-MAEA 818
Score = 42.7 bits (99), Expect = 5e-04
Identities = 37/142 (26%), Positives = 64/142 (45%), Gaps = 15/142 (10%)
Query: 204 REANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEAL 263
RE A A + QLE + E +RL+ +V +L+A+ + + + + L EA+
Sbjct: 765 RELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQS-----QLSMAEAV 819
Query: 264 VQTKDQEIQTLKSQTGG-----PREALEAAERE-----ETQQKVQDLETRNAELEHQLRA 313
++ +Q LK Q +E L+ +ERE E + Q E L+ +L
Sbjct: 820 LREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQEELSQ 879
Query: 314 MERSLEEARAERERARAEVGRA 335
+ S EEA+ E + ++ RA
Sbjct: 880 AKCSSEEAQLEHAELQEQLHRA 901
Score = 38.5 bits (88), Expect = 0.009
Identities = 36/167 (21%), Positives = 75/167 (44%), Gaps = 13/167 (7%)
Query: 185 WEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTP 244
W A D+ + G + AAQ Q+L + ER R +V E+ Q ++++
Sbjct: 371 WLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQL-- 428
Query: 245 TGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRN 304
++ + + Q E A ++ +E+ L+ + G + E ++ +++Q+L
Sbjct: 429 ---EQLVKELQLKEDARASLERLVKEMAPLQEELSG-----KGQEADQLWRRLQELLAHT 480
Query: 305 AELEHQLRAMERSLEEARAERERARAEV---GRAAQLLDVSLFELSE 348
+ E +L + R ++ + E+E EV R Q L+ L ++S+
Sbjct: 481 SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQ 527
Score = 38.5 bits (88), Expect = 0.009
Identities = 46/194 (23%), Positives = 85/194 (43%), Gaps = 27/194 (13%)
Query: 158 QSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQL 217
Q AD T + R + + S+ + + + AL+ K+ R+ +A Q ++L
Sbjct: 377 QKADTASDT-KGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKEL 435
Query: 218 EAQ---RAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQL-----EALVQTKD- 268
+ + RA ERL + +A L+ + + G+GQ +QL E L T
Sbjct: 436 QLKEDARASLERLVKEMAPLQEELS------------GKGQEADQLWRRLQELLAHTSSW 483
Query: 269 ----QEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAE 324
E++ K Q +E LE R T+Q +Q LET+ A++ + +E ++ +
Sbjct: 484 EEELAELRREKKQQQEEKELLEQEVRSLTRQ-LQFLETQLAQVSQHVSDLEEQKKQLIQD 542
Query: 325 RERARAEVGRAAQL 338
++ +VG +L
Sbjct: 543 KDHLSQQVGMLERL 556
Score = 34.3 bits (77), Expect = 0.18
Identities = 42/194 (21%), Positives = 78/194 (40%), Gaps = 19/194 (9%)
Query: 184 QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERL----------RQRVAE 233
Q E E ALQ+ ++ + EA A+ ++QL + L ++RV E
Sbjct: 865 QREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEE 924
Query: 234 LEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLK-------SQTGGPREALE 286
A A E+ E + Q+ L Q K+ + LK S G + +
Sbjct: 925 ALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQ 984
Query: 287 AAEREETQQKV--QDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLF 344
A +R ++ Q+ Q+L T +L ++ + L+ A E + R ++ + L +
Sbjct: 985 AEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEE 1044
Query: 345 ELSELREGLARLAE 358
+ +L+ A + E
Sbjct: 1045 AVEKLKATQADMGE 1058
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 53.5 bits (127), Expect = 3e-07
Identities = 55/235 (23%), Positives = 104/235 (44%), Gaps = 16/235 (6%)
Query: 131 LGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFF 190
L S +V L+ A + K ++++ + E ER + E E E E
Sbjct: 1136 LSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELE-- 1193
Query: 191 ALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEG 250
+L+ L EA A+A R+ + AE RLR+ + E + + V K+
Sbjct: 1194 -------ELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQA 1246
Query: 251 LGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKV------QDLETRN 304
G + EQ+++L + + Q+++ KS+ + L A T+ K + E +
Sbjct: 1247 EGAAELGEQVDSLQRVR-QKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305
Query: 305 AELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
+E + ++ ++R L +A +R R + E G ++LL+ +S+L G A A++
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQS 1360
Score = 43.9 bits (102), Expect = 2e-04
Identities = 66/267 (24%), Positives = 109/267 (40%), Gaps = 35/267 (13%)
Query: 101 QFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSA 160
Q +E +V+E R + S G L + + L+ L+S G+ +S
Sbjct: 1304 QLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEE 1363
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ-----DSNNKLAGALREANAAAAQWRQ 215
E + K L+ +V ++ + + Q ++ +L L +ANA AQWR
Sbjct: 1364 LRRQLEEESKAKSALAH-AVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRS 1422
Query: 216 QLEA---QRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQ 272
+ EA QR E ++ L Q A E G + + SLE+ + +QT+ +++
Sbjct: 1423 KYEADAIQRTEELEEAKKKLALRLQEAEE----GVEAANAKCSSLEKAKLRLQTESEDV- 1477
Query: 273 TLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEV 332
TL+ + A AA A L+ + R +ER+LEE R + E + E+
Sbjct: 1478 TLELE-----RATSAA----------------AALDKKQRHLERALEERRRQEEEMQREL 1516
Query: 333 GRAAQLLDVSLFELSELREGLARLAEA 359
A + EL LR G EA
Sbjct: 1517 EAAQRESRGLGTELFRLRHGHEEALEA 1543
Score = 40.8 bits (94), Expect = 0.002
Identities = 49/199 (24%), Positives = 85/199 (42%), Gaps = 25/199 (12%)
Query: 150 GEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAA 209
GE+ ++ +A G E E K + + + +V+ E + L + + + A R A
Sbjct: 1584 GEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDR-KLAEKDEECANLRRNHQRA 1642
Query: 210 AAQWRQQLEAQ---RAEAERLRQRVA----ELEAQAASEVTPTGEKEGLGQGQSLEQLEA 262
+ L+A+ R EA RL++++ +LE Q LG + + EA
Sbjct: 1643 VESLQASLDAETRARNEALRLKKKMEGDLNDLELQ-------------LGHA-TRQATEA 1688
Query: 263 LVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEAR 322
T+ + Q + Q G E AAE E + Q LE R + L +L + +LE+
Sbjct: 1689 QAATRLMQAQLKEEQAGRDEEQRLAAELHE---QAQALERRASLLAAELEELRAALEQGE 1745
Query: 323 AERERARAEVGRAAQLLDV 341
R A E+ A + L++
Sbjct: 1746 RSRRLAEQELLEATERLNL 1764
Score = 38.1 bits (87), Expect = 0.012
Identities = 43/161 (26%), Positives = 70/161 (43%), Gaps = 15/161 (9%)
Query: 204 REANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEAL 263
R +AAAA ++Q +RA ER RQ E E Q E ++E G G L +L
Sbjct: 1483 RATSAAAALDKKQRHLERALEERRRQ---EEEMQRELEAA---QRESRGLGTELFRLRHG 1536
Query: 264 VQTKDQEIQTLKSQTGGPREALEAAEREETQ--QKVQDLETRNAELEHQLRAMERSLEEA 321
+ + ++TLK + +E + + + + +Q+LE LE + ++ +LEEA
Sbjct: 1537 HEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEA 1596
Query: 322 RAERE-------RARAEVGRAAQLLDVSLFELSELREGLAR 355
E R + E+ + +D L E E L R
Sbjct: 1597 EGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRR 1637
Score = 36.2 bits (82), Expect = 0.047
Identities = 57/199 (28%), Positives = 83/199 (41%), Gaps = 29/199 (14%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFF--ALQDSNNKLAGALREANAAAAQWRQQLEAQRAEA 224
E E+ KK L EG E+Q E AL+ K E + A+ ++L + E
Sbjct: 1574 ELEKTKKAL-EGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEEC 1632
Query: 225 ERLR---QRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG-G 280
LR QR E QA+ + E L + +E ++ L+ Q G
Sbjct: 1633 ANLRRNHQRAVE-SLQASLDAETRARNEALRLKKKMEG----------DLNDLELQLGHA 1681
Query: 281 PREALEA--------AEREETQQKVQDLETRNAELEHQLRAMER--SLEEARAERERARA 330
R+A EA A+ +E Q + + AEL Q +A+ER SL A E RA
Sbjct: 1682 TRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAAL 1741
Query: 331 EVG-RAAQLLDVSLFELSE 348
E G R+ +L + L E +E
Sbjct: 1742 EQGERSRRLAEQELLEATE 1760
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 52.4 bits (124), Expect = 6e-07
Identities = 85/321 (26%), Positives = 122/321 (38%), Gaps = 67/321 (20%)
Query: 84 RANTVYGLGFASEQ--HLTQFAEKFQEVKEAARLAREKS--------QDGG----ELTSP 129
++N + L A +Q L Q EK Q +E R R++ QDG EL
Sbjct: 605 KSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERS 664
Query: 130 ALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWE--- 186
L + S L E L R+ E+ + + L++ G V+ E
Sbjct: 665 HRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSM 724
Query: 187 ----AEFFALQDSNNKLAG----------------ALREANAAAAQWRQQLEAQRA---- 222
AE +LQDS +KL+ A E +A Q RQ+ Q A
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR 784
Query: 223 -EAERLRQ----------------RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQ 265
E ERL + RVAE +A + PT E + L QL +
Sbjct: 785 EEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS 844
Query: 266 TKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAER 325
++QE++ + + EALE A RE+ + L +A L QL A ER E
Sbjct: 845 GREQELEQARREAQRQVEALERAAREK-----EALAKEHAGLAVQLVAAEREGRTLSEEA 899
Query: 326 ERARAEVGRAAQLLDVSLFEL 346
R R E + L+ SLFE+
Sbjct: 900 TRLRLE----KEALEGSLFEV 916
Score = 44.3 bits (103), Expect = 2e-04
Identities = 55/197 (27%), Positives = 87/197 (44%), Gaps = 14/197 (7%)
Query: 164 GPTERERLKKMLSEGSVGEVQWEAEFFAL----QDSNNKLAGALREANAAAAQWRQQLEA 219
G ERE L++ E + E+E +L +D KLA L EA A + +L
Sbjct: 1208 GAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLA-LLEEARTAVGKEAGELRT 1266
Query: 220 QRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG 279
E ER R A E Q + E G+ L +L+ + ++ + + +T
Sbjct: 1267 GLQEVERSRLE-ARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETL 1325
Query: 280 GPREALEAAER--EETQQKVQDLETRNAELEHQLRAMER----SLEEARAERERARAEVG 333
G R+ L E E +Q++Q + + E E + R ER SLEEAR E+ + +
Sbjct: 1326 GLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARG-TEKQQLDHA 1384
Query: 334 RAAQL-LDVSLFELSEL 349
R +L L+ + E +EL
Sbjct: 1385 RGLELKLEAARAEAAEL 1401
Score = 43.5 bits (101), Expect = 3e-04
Identities = 74/267 (27%), Positives = 108/267 (40%), Gaps = 47/267 (17%)
Query: 96 EQHLTQFAEKFQEVKEAA-RLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKL 154
EQ L Q + Q EA R AREK L GLA LV+A G
Sbjct: 847 EQELEQARREAQRQVEALERAAREKEA----LAKEHAGLAVQ------LVAAEREG---- 892
Query: 155 FRSQSADAPGPTERERLKKMLSEGSVGEVQWE-AEFFALQDSNNKLAGALREANAAAAQW 213
R+ S +A R RL+K EGS+ EVQ + A+ A ++ AL A
Sbjct: 893 -RTLSEEAT----RLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK------ 941
Query: 214 RQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQT 273
E E LRQ++ + +A+ +KE + Q LVQ + + +
Sbjct: 942 ----ETLTGELAGLRQQIIATQEKASL------DKELMAQ--------KLVQAEREAQAS 983
Query: 274 LKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQL-RAMERSLEEARAERERARAEV 332
L+ Q E L+ +RE+ + ++LE A+L+ QL R E L AE+E E+
Sbjct: 984 LREQRAAHEEDLQRLQREK-EAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEI 1042
Query: 333 GRAAQLLDVSLFELSELREGLARLAEA 359
Q D L ++ L E+
Sbjct: 1043 AALQQERDEGLLLAESEKQQALSLKES 1069
Score = 43.1 bits (100), Expect = 4e-04
Identities = 56/257 (21%), Positives = 106/257 (41%), Gaps = 15/257 (5%)
Query: 90 GLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVP-PSPLVSANG 148
GL ++ + Q E E R A E +Q GG ++ GL + P P+P
Sbjct: 1402 GLRLSAAEGRAQGLEAELARVEVQRRAAE-AQLGGLRSALRRGLGLGRAPSPAPRPVPGS 1460
Query: 149 PGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNK-LAGALREAN 207
P + P+ E S GS A A D + + + GALRE
Sbjct: 1461 PARDAPAEGSGEGLNSPSTLE-----CSPGSQPPSPGPATSPASPDLDPEAVRGALREFL 1515
Query: 208 AAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTK 267
+++ + R + L +++AE+EA+ S + + + +++ + E ++
Sbjct: 1516 QELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQ-----KAVAESEEARRSV 1570
Query: 268 DQEIQTLKSQTGGPREALEAAEREE--TQQKVQDLETRNAELEHQLRAMERSLEEARAER 325
D + ++++ E++ +ERE T +V LE E +LRA + + + +A
Sbjct: 1571 DGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANE 1630
Query: 326 ERARAEVGRAAQLLDVS 342
+ + R ++LD S
Sbjct: 1631 TKLEGDKRRLKEVLDAS 1647
Score = 42.7 bits (99), Expect = 5e-04
Identities = 45/170 (26%), Positives = 71/170 (41%), Gaps = 4/170 (2%)
Query: 191 ALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGE-KE 249
A + L L A A ++ R+Q + + + LR VA+LE Q + +E
Sbjct: 1758 ACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLRE 1817
Query: 250 GLGQGQSLEQLEA-LVQTKDQEIQTLKSQTGGPREALEA--AEREETQQKVQDLETRNAE 306
L Q Q E VQ E + L+ + G + AL AE+ E ++ LE
Sbjct: 1818 VLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVA 1877
Query: 307 LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARL 356
L L +ER + + R AE GR + L + EL+E + + +L
Sbjct: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQL 1927
Score = 40.4 bits (93), Expect = 0.002
Identities = 56/201 (27%), Positives = 85/201 (42%), Gaps = 33/201 (16%)
Query: 150 GEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAA 209
GE Q +A G + ++L+++L + GE LQD L L A
Sbjct: 1796 GEVADLELQRVEAEG--QLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLGSLQRA 1853
Query: 210 AAQWRQQLEAQRAEAER-----------LRQRVAELEAQAASE----VTPTGEKEGLGQ- 253
AQ LEA++ E ER LR+ + ++E + V + EK L +
Sbjct: 1854 LAQ----LEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRT 1909
Query: 254 --GQSLEQLEALVQTKDQEIQTLK-SQTGGPREALEAAERE--ETQQKVQDLETRNAELE 308
G LE EA Q + E Q + Q+ P + A+++ E QQ+V+ L + A+ E
Sbjct: 1910 LTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTE 1969
Query: 309 HQLRAMERSLEEARAERERAR 329
L A E RA R+R R
Sbjct: 1970 RTLEARE------RAHRQRVR 1984
Score = 39.7 bits (91), Expect = 0.004
Identities = 41/165 (24%), Positives = 73/165 (44%), Gaps = 11/165 (6%)
Query: 202 ALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQ--AASEVTPTGEKEGLGQGQSLEQ 259
AL + R + EA + LR+++++ E++ A E + G Q+ E
Sbjct: 527 ALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED 586
Query: 260 LEALVQTKDQEIQTLKSQTGGPREALEAAER--EETQQKVQDLETRNAELEHQLRAMERS 317
+ VQ + L + +L+ A++ EE +Q+ + L+ EL Q +E
Sbjct: 587 AQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEE 646
Query: 318 LEEARAERERARAEVGRAAQLLD-------VSLFELSELREGLAR 355
E+A + R R E+ R+ + L+ V EL E+RE L+R
Sbjct: 647 QEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSR 691
Score = 39.7 bits (91), Expect = 0.004
Identities = 66/274 (24%), Positives = 112/274 (40%), Gaps = 31/274 (11%)
Query: 104 EKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAP 163
E+ + + A L R EL + ++ + + L +E L S+S
Sbjct: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVK 1653
Query: 164 GPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLE----- 218
+R L+ L +G EA+ ALQD + L + ++ A + +E
Sbjct: 1654 LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA 1713
Query: 219 -AQRAEAE-RLRQRV---AELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQT 273
A+ E+E LR +V E AQ+++ + T +K L+ + + + Q
Sbjct: 1714 LAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKN--------LHLQKALTACEHDRQV 1765
Query: 274 LKSQTGGPREALEAAEREETQ--QKVQDLETRNAELEHQLRAMERSLEEARAERERARAE 331
L+ + R+AL A ++ + ++VQ L A+LE Q E L++ R E R R E
Sbjct: 1766 LQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR-EVLRQRQE 1824
Query: 332 VGRAAQLLDVSLFE---------LSELREGLARL 356
G AA L V + L L+ LA+L
Sbjct: 1825 -GEAAALNTVQKLQDERRLLQERLGSLQRALAQL 1857
Score = 39.3 bits (90), Expect = 0.006
Identities = 47/170 (27%), Positives = 72/170 (42%), Gaps = 28/170 (16%)
Query: 192 LQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGL 251
L+D+ + L L EA + ++ E QR EA LR+ + E G KE
Sbjct: 1166 LEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGE------------GAKERE 1213
Query: 252 GQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLE---TRNAELE 308
+S E+L + V+ + E +LK E+ +QK+ LE T +
Sbjct: 1214 ALRRSNEELRSAVKKAESERISLK------------LANEDKEQKLALLEEARTAVGKEA 1261
Query: 309 HQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELS-ELREGLARLA 357
+LR + +E +R E R E+ R ++LD L EL E RLA
Sbjct: 1262 GELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLA 1311
Score = 37.4 bits (85), Expect = 0.021
Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 30/241 (12%)
Query: 132 GLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFA 191
GL+ + P P S+ G G R S + + L + + + A
Sbjct: 486 GLSGQRTPSPPRRSSPGRGRSPR-RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEA 544
Query: 192 LQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRV---------AELEAQ---AA 239
QD L G LR+ + + R+ LE Q +RLR + A+ E Q +A
Sbjct: 545 SQD----LLGTLRKQLSDSESERRALEEQ---LQRLRDKTDGAMQAHEDAQREVQRLRSA 597
Query: 240 SEVTPTGEKEGLGQGQSLEQLEALVQTKDQE-IQTLKSQTGGPREALEAAEREETQQKVQ 298
+E+ + EK L + Q +A +++E +Q + + R+ LE EE + VQ
Sbjct: 598 NELL-SREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLE----EEQEDAVQ 652
Query: 299 DLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
D A + +L R LE+ +R E+ + L + + L+ A +AE
Sbjct: 653 D----GARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAE 708
Query: 359 A 359
A
Sbjct: 709 A 709
Score = 36.2 bits (82), Expect = 0.047
Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 11/172 (6%)
Query: 187 AEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTG 246
A +LQ+ N L L AQ R + + + + +R+ + E+ T
Sbjct: 74 ASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELE-TQ 132
Query: 247 EKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAE 306
E GL + QS+E L + + + L++ G + + +R Q K+ + R +E
Sbjct: 133 EPRGLVR-QSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR--LQGKILQYKKRCSE 189
Query: 307 LEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
LE QL +ERS E E+ R +Q L+ +L L E ++ A LA+
Sbjct: 190 LEQQL--LERS-----GELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQ 234
Score = 35.8 bits (81), Expect = 0.061
Identities = 45/169 (26%), Positives = 72/169 (42%), Gaps = 27/169 (15%)
Query: 203 LREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEA 262
+REA + A R L+A++AE + + +T +E Q SL +L A
Sbjct: 685 VREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQ-DSLSKLSA 743
Query: 263 LVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
L ++ Q+ + L +Q + AL+ +R+ Q+ R + LE
Sbjct: 744 LNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATV------------AREEQERLE 791
Query: 320 EARAERERAR---------AEVGRAA--QLLDVSLFELSELREGLARLA 357
E R E+E AR AE + A Q L E S+L+E LA+L+
Sbjct: 792 ELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLS 840
Score = 34.7 bits (78), Expect = 0.14
Identities = 42/169 (24%), Positives = 71/169 (42%), Gaps = 18/169 (10%)
Query: 168 RERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER- 226
R+ L+ L + E + L+ ++L L + + + Q+LE R EA+R
Sbjct: 801 RQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQ 860
Query: 227 ---LRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPRE 283
L + E EA A KE G L E +T +E L+ + +E
Sbjct: 861 VEALERAAREKEALA---------KEHAGLAVQLVAAEREGRTLSEEATRLRLE----KE 907
Query: 284 ALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEV 332
ALE + E Q+++ LE R +LE + +A+ + E E R ++
Sbjct: 908 ALEGS-LFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQI 955
Score = 34.7 bits (78), Expect = 0.14
Identities = 51/217 (23%), Positives = 85/217 (39%), Gaps = 51/217 (23%)
Query: 192 LQDSNNKLAGALREANAAAAQWRQQLEAQR--------AEAERLRQRVAELEAQA----- 238
LQ + A RE A AQ + QL+ ++ AE E L + +A L+ +
Sbjct: 995 LQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLL 1054
Query: 239 -------------ASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREAL 285
SE T EK +G SL + ++ + ++ Q+ + Q AL
Sbjct: 1055 LAESEKQQALSLKESEKTALSEKL-MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNAL 1113
Query: 286 EA------AEREET-----------QQKVQDLETRN-------AELEHQLRAMERSLEEA 321
+ A+REE Q++ +DL + EL QLR +E + +
Sbjct: 1114 TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGL 1173
Query: 322 RAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
R E A+ ++ + + +V E ELR L A+
Sbjct: 1174 RRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAK 1210
Score = 33.5 bits (75), Expect = 0.30
Identities = 49/218 (22%), Positives = 87/218 (39%), Gaps = 30/218 (13%)
Query: 97 QHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFR 156
Q L + + QE + AA +K QD L LG S Q + L + E R
Sbjct: 1813 QQLREVLRQRQEGEAAALNTVQKLQDERRLLQERLG--SLQRALAQLEAEKREVERSALR 1870
Query: 157 SQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQ 216
+ +R L++ L + +++ + L +L L A A+ ++Q
Sbjct: 1871 LEK-------DRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQ 1923
Query: 217 LEAQRAEAERLRQR--VAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTL 274
++ A+ L Q A+LE A Q Q LE +Q + + +++
Sbjct: 1924 IQQLEAQVVVLEQSHSPAQLEVDA--------------QQQQLE-----LQQEVERLRSA 1964
Query: 275 KSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLR 312
++QT EA E A R+ + + + T +L+ +LR
Sbjct: 1965 QAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELR 2002
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 52.4 bits (124), Expect = 6e-07
Identities = 66/283 (23%), Positives = 116/283 (40%), Gaps = 26/283 (9%)
Query: 82 DSRANTVYGLGFASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPS 141
D + GL A + L + + +++KE ++ G S A G P
Sbjct: 1063 DQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKL 1122
Query: 142 PLVSANGPGEEKLFRSQSADAPG---PTERERLKKMLSEGSVGEVQWEAEFFA--LQDSN 196
+ A E+ + Q A E ER + + ++ +Q + E A L S
Sbjct: 1123 EALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQ 1182
Query: 197 NKLAGALREANA----------AAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTG 246
+ LA A RE A A +W+ Q+ R EAER ++ LE + +
Sbjct: 1183 SALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVL 1242
Query: 247 EKEGLGQGQSLEQLEALVQTKDQEIQ----TLKSQTGGPREALEAAEREETQQKVQDLET 302
EKE G+ + L++L K Q+++ L+++T + AAER + +++++
Sbjct: 1243 EKE--GESKELKRLVMAESEKSQKLEERLRLLQAETAS--NSARAAERSSALR--EEVQS 1296
Query: 303 RNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFE 345
E E Q A E +E ++ ERA E+G+ + F+
Sbjct: 1297 LREEAEKQRVASENLRQELTSQAERAE-ELGQELKAWQEKFFQ 1338
Score = 47.0 bits (110), Expect = 3e-05
Identities = 71/285 (24%), Positives = 124/285 (43%), Gaps = 29/285 (10%)
Query: 94 ASEQHLTQFAEKFQEVKEA--ARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGE 151
+S +L+Q E+ ++ +A ARL + + ELT+ A+ Q L +
Sbjct: 473 SSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLN---ATIQQQDQELAGLKQQAK 529
Query: 152 EK-------LFRSQSADAPGPTERERLKKMLS--EGSVGEVQWEAEFFALQDSNNKLAGA 202
EK L + + A + E+L L E + EV E + QD +LA A
Sbjct: 530 EKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVA-EKQEATRQDHAQQLATA 588
Query: 203 -------LREANAAAAQWRQQLEAQRAEAERLRQR--VAELEAQAASEVTPTGEKEGLGQ 253
LRE +AA Q + + A+ E L+Q+ VA +A ++E
Sbjct: 589 AEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAEL 648
Query: 254 GQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRA 313
+ +E+L+A V+T QE ++Q L + +++ T++ + + +L+ QL+A
Sbjct: 649 SRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK--ERVAQEKDQLQEQLQA 706
Query: 314 MERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
++ SL+ + E E RAA L+ +SEL+ L E
Sbjct: 707 LKESLKVTKGSLEE---EKRRAADALEEQQRCISELKAETRSLVE 748
Score = 45.4 bits (106), Expect = 8e-05
Identities = 63/212 (29%), Positives = 89/212 (41%), Gaps = 24/212 (11%)
Query: 167 ERERLKKMLSEGSVGEV--QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLE----AQ 220
ER R M S+G E Q E E L + L AA A+ +L+ Q
Sbjct: 982 ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
Query: 221 RAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQT----KDQEIQTLKS 276
R E L++ +A + + + GL Q +++LE L QT K+Q + K
Sbjct: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQ-IKELEELRQTVKQLKEQLAKKEKE 1100
Query: 277 QTGGPREALEAAEREE-TQQKVQDLETRNAELEHQLR-------AMERSLEEARAERERA 328
G EAA R E T K++ L ++LE Q + ++ERSLE RA +
Sbjct: 1101 HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERA----S 1156
Query: 329 RAEVGRAAQLLDVSLFE-LSELREGLARLAEA 359
RAE A + L L E EL + LA A
Sbjct: 1157 RAERDSALETLQGQLEEKAQELGHSQSALASA 1188
Score = 43.9 bits (102), Expect = 2e-04
Identities = 48/204 (23%), Positives = 94/204 (46%), Gaps = 33/204 (16%)
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
EE + +D ++++LK + ++G GE Q EA+ LQ N+L L + AA
Sbjct: 1552 EELSKKLADSDQASKVQQQKLKAVQAQG--GESQQEAQ--RLQAQLNELQAQLSQKEQAA 1607
Query: 211 AQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQE 270
++ Q+E + + +Q+ EL+ Q +SLEQL Q +++E
Sbjct: 1608 EHYKLQMEKAKTHYDAKKQQNQELQEQL----------------RSLEQL----QKENKE 1647
Query: 271 IQTLKSQTGG--PREALEAAEREET----QQKVQDLETRNAELEHQLRAMER---SLEEA 321
++ + G + L+ E E+T +V+ LE + A + QLR + + + +
Sbjct: 1648 LRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDAL 1707
Query: 322 RAERERARAEVGRAAQLLDVSLFE 345
++ +A+ ++ + LD+S E
Sbjct: 1708 KSREPQAKPQLDLSIDSLDLSCEE 1731
Score = 43.5 bits (101), Expect = 3e-04
Identities = 67/295 (22%), Positives = 113/295 (38%), Gaps = 53/295 (17%)
Query: 95 SEQHLTQFAEKFQE----VKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPG 150
S+Q Q+ FQE +KE AR++ Q+ E + G+ SH
Sbjct: 820 SQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVA---GIESHS------------- 863
Query: 151 EEKLFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAA 210
E ++ R Q+ A R + + E V + + LQ+ K+A +E
Sbjct: 864 ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQE---KMAATSKEVARLE 920
Query: 211 AQWRQQLEAQRAEAERLRQRVAE--------LEAQAASEVTPTG------EKEGLGQGQS 256
R+ E Q + L + A LE Q + T E+E G
Sbjct: 921 TLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNE 980
Query: 257 LEQLEALVQT-----------KDQEIQTLKSQTGGPRE--ALEAAEREETQQKVQDLETR 303
LE+L A + +++E+ L + G + ALE A R E + ++Q+
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALN- 1039
Query: 304 NAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
E + ++ +L A E+E E+ + L + EL ELR+ + +L E
Sbjct: 1040 --EQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKE 1092
Score = 43.5 bits (101), Expect = 3e-04
Identities = 64/265 (24%), Positives = 112/265 (42%), Gaps = 13/265 (4%)
Query: 97 QHLTQFAEKFQEVKEAARLAREKS-QDGGELTSPALGLASHQVPPSPLVSANGPGEEKLF 155
Q LT AE+ +E+ + + +EK Q L++ L S Q S L+ A + L
Sbjct: 1313 QELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPA-----KHLC 1367
Query: 156 RSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQ 215
+ A+ +R R + S+ + G ++ AE Q +L LR+ A + Q
Sbjct: 1368 QQLQAEQAAAEKRHREELEQSKQAAGGLR--AELLRAQRELGELI-PLRQKVAEQERTAQ 1424
Query: 216 QLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLK 275
QL A++A + + A E GE+ LG+ Q LE L Q +++ +Q L
Sbjct: 1425 QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGR-QFLEV--ELDQAREKYVQELA 1481
Query: 276 SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRA 335
+ L +RE Q ++LE A+ E + + + ER++ A+V +
Sbjct: 1482 AVRADAETRLAEVQRE-AQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQL 1540
Query: 336 AQLLDVSLFELSELREGLARLAEAA 360
++ EL + LA +A+
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQAS 1565
Score = 42.0 bits (97), Expect = 9e-04
Identities = 44/170 (25%), Positives = 79/170 (46%), Gaps = 20/170 (11%)
Query: 194 DSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASE---VTPTGEKEG 250
D+ +LA REA + A ++LE A+ E + +V E + E +T E+
Sbjct: 1486 DAETRLAEVQREAQSTA----RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLE 1541
Query: 251 LGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAERE--ETQQKVQDLETRNAELE 308
+ Q + +Q+E L + Q K Q ++ L+A + + E+QQ+ Q L+ + EL+
Sbjct: 1542 VFQREQTKQVEELSKKLADSDQASKVQ----QQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597
Query: 309 HQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAE 358
QL E++ E + + E+A+ D + EL+E L L +
Sbjct: 1598 AQLSQKEQAAEHYKLQMEKAKTH-------YDAKKQQNQELQEQLRSLEQ 1640
Score = 41.6 bits (96), Expect = 0.001
Identities = 46/189 (24%), Positives = 81/189 (42%), Gaps = 17/189 (8%)
Query: 176 SEGSVGEVQWEAEFFA--LQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLR--QRV 231
+E + EVQ EA+ A L+ K GA + +++++ + A+ E+L QR
Sbjct: 1487 AETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
Query: 232 AELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAERE 291
+ + S+ ++ Q Q L+ ++A QE Q L++Q + L E+
Sbjct: 1547 QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
Query: 292 ETQQKVQDLETR---------NAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVS 342
K+Q + + N EL+ QLR SLE+ + E + RAE R L +
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLR----SLEQLQKENKELRAEAERLGHELQQA 1662
Query: 343 LFELSELRE 351
+ E +
Sbjct: 1663 GLKTKEAEQ 1671
Score = 39.7 bits (91), Expect = 0.004
Identities = 46/191 (24%), Positives = 76/191 (39%), Gaps = 22/191 (11%)
Query: 184 QWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVT 243
Q + + L + N L+ LRE + Q + L E + Q E +AQ E++
Sbjct: 308 QMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELS 367
Query: 244 PT-------GEKEGLGQGQSLEQLEALVQTKDQEIQ--------TLKSQTGGPREALEAA 288
EK + QG+ + E L Q +D Q L+ +T A AA
Sbjct: 368 AALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAA 427
Query: 289 EREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSE 348
+ Q +V+ LET + E +L A EE + + + L S+ LS+
Sbjct: 428 NNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITD-------LQSSISNLSQ 480
Query: 349 LREGLARLAEA 359
+E L + ++A
Sbjct: 481 AKEELEQASQA 491
Score = 38.1 bits (87), Expect = 0.012
Identities = 59/271 (21%), Positives = 109/271 (40%), Gaps = 51/271 (18%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
+EK Q+++E RL + ++ + +V S E++ S++
Sbjct: 1259 SEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ-----SLREEAEKQRVASENLRQ 1313
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKL------AGALREANAAAAQWRQQ 216
++ ER +++ E W+ +FF + + + L AL A QQ
Sbjct: 1314 ELTSQAERAEELGQELKA----WQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQ 1369
Query: 217 LEAQRAEAERLRQRVAELEAQAA--------------SEVTPTGEKEGLGQGQSLEQLEA 262
L+A++A AE+ + E QAA E+ P +K Q ++ +QL A
Sbjct: 1370 LQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVA-EQERTAQQLRA 1428
Query: 263 LVQTKDQEIQTLKSQTG--------------GPREALEAAEREETQQKVQDL-------E 301
+ +++ LK G R+ LE + ++ VQ+L E
Sbjct: 1429 EKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAE 1488
Query: 302 TRNAELEHQLRAMERSLEEARAERERARAEV 332
TR AE++ + ++ R LE A+ E A+ +V
Sbjct: 1489 TRLAEVQREAQSTARELEVMTAKYEGAKVKV 1519
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 51.6 bits (122), Expect = 1e-06
Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)
Query: 150 GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
GE + R+++ +A E ERL++ + + S + Q E E + + + A +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 205 EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
A A + R Q E ++AE ER RQ AEL+++ AS T +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 249 EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
E +SL++ V +E + Q A E AERE + +++ E L+
Sbjct: 1593 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 309 HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
+ A ++SL +A AE+++ AE R +L + L + +L EG A+
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 357 AEAA 360
AA
Sbjct: 1708 RLAA 1711
Score = 49.7 bits (117), Expect = 4e-06
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1708 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1758
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1759 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1797
Query: 283 EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
E E A R L E + Q + E RAE ER AE +G A +L
Sbjct: 1798 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848
Query: 339 ---LDVSLFELSELREGLARLAE 358
+++L E E L RLAE
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAE 1871
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 266 T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
+ KD +Q + Q E L E + QQ ++ + + ++E + + + S+E
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 320 EARAERERARAEVGRAAQLL 339
EAR + A V R + L
Sbjct: 2554 EARRRQHEAEEGVRRKQEEL 2573
Score = 42.7 bits (99), Expect = 5e-04
Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)
Query: 151 EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
EE+L Q A+ ERERL ++ L+E + Q E E LQ ++
Sbjct: 1347 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1398
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
+ AA +QQ + + E ++LRQ +E E QA + E+ L + +
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1457
Query: 259 --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
QLEA + + + E+Q L+++ R+A E AER Q + + R AE+E
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 309 ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
L+A+E L+ AER +AEV RA Q+
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
AA + ++L+A+ EA RLR+R + L +AA + EK Q EQ L
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 261 EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
+ +Q + + L+ + R A E AE RE Q ++V++ E E Q
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 312 RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
+A ++ A R+ A E R AQ +L
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
E ERLK+ E + Q +A L+ + A +A AA + +Q +A+ + ++
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 227 LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
++ +AQ E+T E Q +E+
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 264 VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
V+ + +E+ LK++ AL +++ TQ+ +Q+ + ++ + + + +EA
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 324 ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
R+ A ++ + L + L E + + RL AEA
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2329
Score = 39.3 bits (90), Expect = 0.006
Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E ARL RE + + LA + L+++ EE ++ +E+
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1785
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
+ + G E+ EA K L E +AA RQ+ EA+R AE+L
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1841
Query: 230 RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
+ +E+ EKE E+L L + + + + L+ Q + +E
Sbjct: 1842 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 287 -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
A++ E +QK V+D + ++E ++ A++ S E+A A + E+GR
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Score = 39.3 bits (90), Expect = 0.006
Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)
Query: 94 ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
A + L + AE E + RL + +Q ++ L + S L G E+
Sbjct: 1861 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1916
Query: 154 LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
L + + + E LK + + G+ + E E ++ + + +A AA+
Sbjct: 1917 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 214 RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
RQ + E +R EAE R R+ E + + A + E+E
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 251 -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
L Q + ++L+A VQ K+QE+ Q++ Q G EA A E
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 292 ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
+ +VQ E A+ Q+ ER L+++ E+ +ARA+ AA+ L E +
Sbjct: 2093 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2144
Query: 352 GLARLAEA 359
AR A+A
Sbjct: 2145 EAARRAQA 2152
Score = 32.7 bits (73), Expect = 0.52
Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
A+ ++V+EA RL ++ +++ + + A A + +A E+ L + Q+A
Sbjct: 2105 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
DA E E+ KK + + Q E E L+ + +L EA
Sbjct: 2164 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 207 NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
+Q ++L + R + E L + A +EA+ + + T +E + + + +
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 261 EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
A + QE ++ L + + AL +E Q VQ+ AE E + E +
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2339
Query: 318 LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
E+AR R + + + AQ +L+E +G R EA
Sbjct: 2340 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2370
Score = 28.5 bits (62), Expect = 9.8
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)
Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
EE Q +V DL + A+L R + +S+EE RA+ ERAR++ G+
Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 581
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 51.6 bits (122), Expect = 1e-06
Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)
Query: 150 GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
GE + R+++ +A E ERL++ + + S + Q E E + + + A +
Sbjct: 1477 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536
Query: 205 EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
A A + R Q E ++AE ER RQ AEL+++ AS T +
Sbjct: 1537 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1596
Query: 249 EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
E +SL++ V +E + Q A E AERE + +++ E L+
Sbjct: 1597 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Query: 309 HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
+ A ++SL +A AE+++ AE R +L + L + +L EG A+
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711
Query: 357 AEAA 360
AA
Sbjct: 1712 RLAA 1715
Score = 49.7 bits (117), Expect = 4e-06
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1712 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1762
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1763 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1801
Query: 283 EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
E E A R L E + Q + E RAE ER AE +G A +L
Sbjct: 1802 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1852
Query: 339 ---LDVSLFELSELREGLARLAE 358
+++L E E L RLAE
Sbjct: 1853 KTEAEIALKEKEAENERLRRLAE 1875
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2318 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2377
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2378 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2437
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497
Query: 266 T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
+ KD +Q + Q E L E + QQ ++ + + ++E + + + S+E
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2557
Query: 320 EARAERERARAEVGRAAQLL 339
EAR + A V R + L
Sbjct: 2558 EARRRQHEAEEGVRRKQEEL 2577
Score = 42.7 bits (99), Expect = 5e-04
Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)
Query: 151 EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
EE+L Q A+ ERERL ++ L+E + Q E E LQ ++
Sbjct: 1351 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1402
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
+ AA +QQ + + E ++LRQ +E E QA + E+ L + +
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1461
Query: 259 --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
QLEA + + + E+Q L+++ R+A E AER Q + + R AE+E
Sbjct: 1462 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521
Query: 309 ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
L+A+E L+ AER +AEV RA Q+
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1567
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
AA + ++L+A+ EA RLR+R + L +AA + EK Q EQ L
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2069
Query: 261 EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
+ +Q + + L+ + R A E AE RE Q ++V++ E E Q
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129
Query: 312 RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
+A ++ A R+ A E R AQ +L
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2161
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
E ERLK+ E + Q +A L+ + A +A AA + +Q +A+ + ++
Sbjct: 2117 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2176
Query: 227 LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
++ +AQ E+T E Q +E+
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2236
Query: 264 VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
V+ + +E+ LK++ AL +++ TQ+ +Q+ + ++ + + + +EA
Sbjct: 2237 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2296
Query: 324 ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
R+ A ++ + L + L E + + RL AEA
Sbjct: 2297 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2333
Score = 39.3 bits (90), Expect = 0.006
Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E ARL RE + + LA + L+++ EE ++ +E+
Sbjct: 1738 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1789
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
+ + G E+ EA K L E +AA RQ+ EA+R AE+L
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1845
Query: 230 RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
+ +E+ EKE E+L L + + + + L+ Q + +E
Sbjct: 1846 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899
Query: 287 -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
A++ E +QK V+D + ++E ++ A++ S E+A A + E+GR
Sbjct: 1900 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1954
Score = 39.3 bits (90), Expect = 0.006
Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)
Query: 94 ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
A + L + AE E + RL + +Q ++ L + S L G E+
Sbjct: 1865 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1920
Query: 154 LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
L + + + E LK + + G+ + E E ++ + + +A AA+
Sbjct: 1921 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 214 RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
RQ + E +R EAE R R+ E + + A + E+E
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2036
Query: 251 -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
L Q + ++L+A VQ K+QE+ Q++ Q G EA A E
Sbjct: 2037 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2096
Query: 292 ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
+ +VQ E A+ Q+ ER L+++ E+ +ARA+ AA+ L E +
Sbjct: 2097 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2148
Query: 352 GLARLAEA 359
AR A+A
Sbjct: 2149 EAARRAQA 2156
Score = 32.7 bits (73), Expect = 0.52
Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
A+ ++V+EA RL ++ +++ + + A A + +A E+ L + Q+A
Sbjct: 2109 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
DA E E+ KK + + Q E E L+ + +L EA
Sbjct: 2168 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2223
Query: 207 NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
+Q ++L + R + E L + A +EA+ + + T +E + + + +
Sbjct: 2224 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283
Query: 261 EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
A + QE ++ L + + AL +E Q VQ+ AE E + E +
Sbjct: 2284 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2343
Query: 318 LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
E+AR R + + + AQ +L+E +G R EA
Sbjct: 2344 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2374
Score = 28.5 bits (62), Expect = 9.8
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)
Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
EE Q +V DL + A+L R + +S+EE RA+ ERAR++ G+
Sbjct: 537 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 585
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 51.6 bits (122), Expect = 1e-06
Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)
Query: 150 GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
GE + R+++ +A E ERL++ + + S + Q E E + + + A +
Sbjct: 1473 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
Query: 205 EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
A A + R Q E ++AE ER RQ AEL+++ AS T +
Sbjct: 1533 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1592
Query: 249 EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
E +SL++ V +E + Q A E AERE + +++ E L+
Sbjct: 1593 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 309 HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
+ A ++SL +A AE+++ AE R +L + L + +L EG A+
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 357 AEAA 360
AA
Sbjct: 1708 RLAA 1711
Score = 49.7 bits (117), Expect = 4e-06
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1708 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1758
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1759 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1797
Query: 283 EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
E E A R L E + Q + E RAE ER AE +G A +L
Sbjct: 1798 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848
Query: 339 ---LDVSLFELSELREGLARLAE 358
+++L E E L RLAE
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAE 1871
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2314 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2373
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2374 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2433
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 266 T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
+ KD +Q + Q E L E + QQ ++ + + ++E + + + S+E
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 320 EARAERERARAEVGRAAQLL 339
EAR + A V R + L
Sbjct: 2554 EARRRQHEAEEGVRRKQEEL 2573
Score = 42.7 bits (99), Expect = 5e-04
Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)
Query: 151 EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
EE+L Q A+ ERERL ++ L+E + Q E E LQ ++
Sbjct: 1347 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1398
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
+ AA +QQ + + E ++LRQ +E E QA + E+ L + +
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1457
Query: 259 --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
QLEA + + + E+Q L+++ R+A E AER Q + + R AE+E
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 309 ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
L+A+E L+ AER +AEV RA Q+
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1563
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
AA + ++L+A+ EA RLR+R + L +AA + EK Q EQ L
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 261 EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
+ +Q + + L+ + R A E AE RE Q ++V++ E E Q
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125
Query: 312 RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
+A ++ A R+ A E R AQ +L
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2157
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
E ERLK+ E + Q +A L+ + A +A AA + +Q +A+ + ++
Sbjct: 2113 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2172
Query: 227 LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
++ +AQ E+T E Q +E+
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2232
Query: 264 VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
V+ + +E+ LK++ AL +++ TQ+ +Q+ + ++ + + + +EA
Sbjct: 2233 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2292
Query: 324 ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
R+ A ++ + L + L E + + RL AEA
Sbjct: 2293 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2329
Score = 39.3 bits (90), Expect = 0.006
Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E ARL RE + + LA + L+++ EE ++ +E+
Sbjct: 1734 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1785
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
+ + G E+ EA K L E +AA RQ+ EA+R AE+L
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1841
Query: 230 RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
+ +E+ EKE E+L L + + + + L+ Q + +E
Sbjct: 1842 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 287 -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
A++ E +QK V+D + ++E ++ A++ S E+A A + E+GR
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1950
Score = 39.3 bits (90), Expect = 0.006
Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)
Query: 94 ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
A + L + AE E + RL + +Q ++ L + S L G E+
Sbjct: 1861 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1916
Query: 154 LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
L + + + E LK + + G+ + E E ++ + + +A AA+
Sbjct: 1917 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 214 RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
RQ + E +R EAE R R+ E + + A + E+E
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2032
Query: 251 -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
L Q + ++L+A VQ K+QE+ Q++ Q G EA A E
Sbjct: 2033 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2092
Query: 292 ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
+ +VQ E A+ Q+ ER L+++ E+ +ARA+ AA+ L E +
Sbjct: 2093 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2144
Query: 352 GLARLAEA 359
AR A+A
Sbjct: 2145 EAARRAQA 2152
Score = 32.7 bits (73), Expect = 0.52
Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
A+ ++V+EA RL ++ +++ + + A A + +A E+ L + Q+A
Sbjct: 2105 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
DA E E+ KK + + Q E E L+ + +L EA
Sbjct: 2164 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 207 NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
+Q ++L + R + E L + A +EA+ + + T +E + + + +
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 261 EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
A + QE ++ L + + AL +E Q VQ+ AE E + E +
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2339
Query: 318 LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
E+AR R + + + AQ +L+E +G R EA
Sbjct: 2340 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2370
Score = 28.5 bits (62), Expect = 9.8
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)
Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
EE Q +V DL + A+L R + +S+EE RA+ ERAR++ G+
Sbjct: 533 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 581
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 51.6 bits (122), Expect = 1e-06
Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)
Query: 150 GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
GE + R+++ +A E ERL++ + + S + Q E E + + + A +
Sbjct: 1441 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500
Query: 205 EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
A A + R Q E ++AE ER RQ AEL+++ AS T +
Sbjct: 1501 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1560
Query: 249 EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
E +SL++ V +E + Q A E AERE + +++ E L+
Sbjct: 1561 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Query: 309 HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
+ A ++SL +A AE+++ AE R +L + L + +L EG A+
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675
Query: 357 AEAA 360
AA
Sbjct: 1676 RLAA 1679
Score = 49.7 bits (117), Expect = 4e-06
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1676 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1726
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1727 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1765
Query: 283 EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
E E A R L E + Q + E RAE ER AE +G A +L
Sbjct: 1766 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1816
Query: 339 ---LDVSLFELSELREGLARLAE 358
+++L E E L RLAE
Sbjct: 1817 KTEAEIALKEKEAENERLRRLAE 1839
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2282 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2341
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2342 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2401
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461
Query: 266 T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
+ KD +Q + Q E L E + QQ ++ + + ++E + + + S+E
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2521
Query: 320 EARAERERARAEVGRAAQLL 339
EAR + A V R + L
Sbjct: 2522 EARRRQHEAEEGVRRKQEEL 2541
Score = 42.7 bits (99), Expect = 5e-04
Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)
Query: 151 EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
EE+L Q A+ ERERL ++ L+E + Q E E LQ ++
Sbjct: 1315 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1366
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
+ AA +QQ + + E ++LRQ +E E QA + E+ L + +
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1425
Query: 259 --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
QLEA + + + E+Q L+++ R+A E AER Q + + R AE+E
Sbjct: 1426 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1485
Query: 309 ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
L+A+E L+ AER +AEV RA Q+
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1531
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
AA + ++L+A+ EA RLR+R + L +AA + EK Q EQ L
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2033
Query: 261 EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
+ +Q + + L+ + R A E AE RE Q ++V++ E E Q
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093
Query: 312 RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
+A ++ A R+ A E R AQ +L
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2125
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
E ERLK+ E + Q +A L+ + A +A AA + +Q +A+ + ++
Sbjct: 2081 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2140
Query: 227 LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
++ +AQ E+T E Q +E+
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2200
Query: 264 VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
V+ + +E+ LK++ AL +++ TQ+ +Q+ + ++ + + + +EA
Sbjct: 2201 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2260
Query: 324 ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
R+ A ++ + L + L E + + RL AEA
Sbjct: 2261 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2297
Score = 39.3 bits (90), Expect = 0.006
Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E ARL RE + + LA + L+++ EE ++ +E+
Sbjct: 1702 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1753
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
+ + G E+ EA K L E +AA RQ+ EA+R AE+L
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1809
Query: 230 RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
+ +E+ EKE E+L L + + + + L+ Q + +E
Sbjct: 1810 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863
Query: 287 -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
A++ E +QK V+D + ++E ++ A++ S E+A A + E+GR
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1918
Score = 39.3 bits (90), Expect = 0.006
Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)
Query: 94 ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
A + L + AE E + RL + +Q ++ L + S L G E+
Sbjct: 1829 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1884
Query: 154 LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
L + + + E LK + + G+ + E E ++ + + +A AA+
Sbjct: 1885 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 214 RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
RQ + E +R EAE R R+ E + + A + E+E
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2000
Query: 251 -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
L Q + ++L+A VQ K+QE+ Q++ Q G EA A E
Sbjct: 2001 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2060
Query: 292 ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
+ +VQ E A+ Q+ ER L+++ E+ +ARA+ AA+ L E +
Sbjct: 2061 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2112
Query: 352 GLARLAEA 359
AR A+A
Sbjct: 2113 EAARRAQA 2120
Score = 32.7 bits (73), Expect = 0.52
Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
A+ ++V+EA RL ++ +++ + + A A + +A E+ L + Q+A
Sbjct: 2073 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
DA E E+ KK + + Q E E L+ + +L EA
Sbjct: 2132 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2187
Query: 207 NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
+Q ++L + R + E L + A +EA+ + + T +E + + + +
Sbjct: 2188 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247
Query: 261 EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
A + QE ++ L + + AL +E Q VQ+ AE E + E +
Sbjct: 2248 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2307
Query: 318 LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
E+AR R + + + AQ +L+E +G R EA
Sbjct: 2308 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2338
Score = 28.5 bits (62), Expect = 9.8
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)
Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
EE Q +V DL + A+L R + +S+EE RA+ ERAR++ G+
Sbjct: 501 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 549
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 51.6 bits (122), Expect = 1e-06
Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)
Query: 150 GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
GE + R+++ +A E ERL++ + + S + Q E E + + + A +
Sbjct: 1610 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669
Query: 205 EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
A A + R Q E ++AE ER RQ AEL+++ AS T +
Sbjct: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729
Query: 249 EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
E +SL++ V +E + Q A E AERE + +++ E L+
Sbjct: 1730 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Query: 309 HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
+ A ++SL +A AE+++ AE R +L + L + +L EG A+
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844
Query: 357 AEAA 360
AA
Sbjct: 1845 RLAA 1848
Score = 49.7 bits (117), Expect = 4e-06
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1845 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1895
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1896 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1934
Query: 283 EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
E E A R L E + Q + E RAE ER AE +G A +L
Sbjct: 1935 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1985
Query: 339 ---LDVSLFELSELREGLARLAE 358
+++L E E L RLAE
Sbjct: 1986 KTEAEIALKEKEAENERLRRLAE 2008
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630
Query: 266 T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
+ KD +Q + Q E L E + QQ ++ + + ++E + + + S+E
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690
Query: 320 EARAERERARAEVGRAAQLL 339
EAR + A V R + L
Sbjct: 2691 EARRRQHEAEEGVRRKQEEL 2710
Score = 42.7 bits (99), Expect = 5e-04
Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)
Query: 151 EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
EE+L Q A+ ERERL ++ L+E + Q E E LQ ++
Sbjct: 1484 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1535
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
+ AA +QQ + + E ++LRQ +E E QA + E+ L + +
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1594
Query: 259 --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
QLEA + + + E+Q L+++ R+A E AER Q + + R AE+E
Sbjct: 1595 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654
Query: 309 ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
L+A+E L+ AER +AEV RA Q+
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1700
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
AA + ++L+A+ EA RLR+R + L +AA + EK Q EQ L
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2202
Query: 261 EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
+ +Q + + L+ + R A E AE RE Q ++V++ E E Q
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262
Query: 312 RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
+A ++ A R+ A E R AQ +L
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
E ERLK+ E + Q +A L+ + A +A AA + +Q +A+ + ++
Sbjct: 2250 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2309
Query: 227 LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
++ +AQ E+T E Q +E+
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2369
Query: 264 VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
V+ + +E+ LK++ AL +++ TQ+ +Q+ + ++ + + + +EA
Sbjct: 2370 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2429
Query: 324 ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
R+ A ++ + L + L E + + RL AEA
Sbjct: 2430 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2466
Score = 39.3 bits (90), Expect = 0.006
Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E ARL RE + + LA + L+++ EE ++ +E+
Sbjct: 1871 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1922
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
+ + G E+ EA K L E +AA RQ+ EA+R AE+L
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1978
Query: 230 RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
+ +E+ EKE E+L L + + + + L+ Q + +E
Sbjct: 1979 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032
Query: 287 -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
A++ E +QK V+D + ++E ++ A++ S E+A A + E+GR
Sbjct: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087
Score = 39.3 bits (90), Expect = 0.006
Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)
Query: 94 ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
A + L + AE E + RL + +Q ++ L + S L G E+
Sbjct: 1998 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 2053
Query: 154 LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
L + + + E LK + + G+ + E E ++ + + +A AA+
Sbjct: 2054 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 214 RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
RQ + E +R EAE R R+ E + + A + E+E
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2169
Query: 251 -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
L Q + ++L+A VQ K+QE+ Q++ Q G EA A E
Sbjct: 2170 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2229
Query: 292 ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
+ +VQ E A+ Q+ ER L+++ E+ +ARA+ AA+ L E +
Sbjct: 2230 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2281
Query: 352 GLARLAEA 359
AR A+A
Sbjct: 2282 EAARRAQA 2289
Score = 32.7 bits (73), Expect = 0.52
Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
A+ ++V+EA RL ++ +++ + + A A + +A E+ L + Q+A
Sbjct: 2242 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
DA E E+ KK + + Q E E L+ + +L EA
Sbjct: 2301 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2356
Query: 207 NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
+Q ++L + R + E L + A +EA+ + + T +E + + + +
Sbjct: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416
Query: 261 EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
A + QE ++ L + + AL +E Q VQ+ AE E + E +
Sbjct: 2417 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2476
Query: 318 LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
E+AR R + + + AQ +L+E +G R EA
Sbjct: 2477 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2507
Score = 28.5 bits (62), Expect = 9.8
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)
Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
EE Q +V DL + A+L R + +S+EE RA+ ERAR++ G+
Sbjct: 670 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 718
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 51.6 bits (122), Expect = 1e-06
Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)
Query: 150 GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
GE + R+++ +A E ERL++ + + S + Q E E + + + A +
Sbjct: 1451 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1510
Query: 205 EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
A A + R Q E ++AE ER RQ AEL+++ AS T +
Sbjct: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570
Query: 249 EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
E +SL++ V +E + Q A E AERE + +++ E L+
Sbjct: 1571 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
Query: 309 HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
+ A ++SL +A AE+++ AE R +L + L + +L EG A+
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685
Query: 357 AEAA 360
AA
Sbjct: 1686 RLAA 1689
Score = 49.7 bits (117), Expect = 4e-06
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1686 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1736
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1737 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1775
Query: 283 EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
E E A R L E + Q + E RAE ER AE +G A +L
Sbjct: 1776 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1826
Query: 339 ---LDVSLFELSELREGLARLAE 358
+++L E E L RLAE
Sbjct: 1827 KTEAEIALKEKEAENERLRRLAE 1849
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471
Query: 266 T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
+ KD +Q + Q E L E + QQ ++ + + ++E + + + S+E
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
Query: 320 EARAERERARAEVGRAAQLL 339
EAR + A V R + L
Sbjct: 2532 EARRRQHEAEEGVRRKQEEL 2551
Score = 42.7 bits (99), Expect = 5e-04
Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)
Query: 151 EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
EE+L Q A+ ERERL ++ L+E + Q E E LQ ++
Sbjct: 1325 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1376
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
+ AA +QQ + + E ++LRQ +E E QA + E+ L + +
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1435
Query: 259 --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
QLEA + + + E+Q L+++ R+A E AER Q + + R AE+E
Sbjct: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
Query: 309 ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
L+A+E L+ AER +AEV RA Q+
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1541
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
AA + ++L+A+ EA RLR+R + L +AA + EK Q EQ L
Sbjct: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2043
Query: 261 EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
+ +Q + + L+ + R A E AE RE Q ++V++ E E Q
Sbjct: 2044 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103
Query: 312 RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
+A ++ A R+ A E R AQ +L
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
E ERLK+ E + Q +A L+ + A +A AA + +Q +A+ + ++
Sbjct: 2091 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2150
Query: 227 LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
++ +AQ E+T E Q +E+
Sbjct: 2151 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2210
Query: 264 VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
V+ + +E+ LK++ AL +++ TQ+ +Q+ + ++ + + + +EA
Sbjct: 2211 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2270
Query: 324 ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
R+ A ++ + L + L E + + RL AEA
Sbjct: 2271 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2307
Score = 39.3 bits (90), Expect = 0.006
Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E ARL RE + + LA + L+++ EE ++ +E+
Sbjct: 1712 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1763
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
+ + G E+ EA K L E +AA RQ+ EA+R AE+L
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1819
Query: 230 RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
+ +E+ EKE E+L L + + + + L+ Q + +E
Sbjct: 1820 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873
Query: 287 -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
A++ E +QK V+D + ++E ++ A++ S E+A A + E+GR
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928
Score = 39.3 bits (90), Expect = 0.006
Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)
Query: 94 ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
A + L + AE E + RL + +Q ++ L + S L G E+
Sbjct: 1839 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1894
Query: 154 LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
L + + + E LK + + G+ + E E ++ + + +A AA+
Sbjct: 1895 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 214 RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
RQ + E +R EAE R R+ E + + A + E+E
Sbjct: 1951 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2010
Query: 251 -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
L Q + ++L+A VQ K+QE+ Q++ Q G EA A E
Sbjct: 2011 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2070
Query: 292 ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
+ +VQ E A+ Q+ ER L+++ E+ +ARA+ AA+ L E +
Sbjct: 2071 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2122
Query: 352 GLARLAEA 359
AR A+A
Sbjct: 2123 EAARRAQA 2130
Score = 32.7 bits (73), Expect = 0.52
Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
A+ ++V+EA RL ++ +++ + + A A + +A E+ L + Q+A
Sbjct: 2083 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
DA E E+ KK + + Q E E L+ + +L EA
Sbjct: 2142 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2197
Query: 207 NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
+Q ++L + R + E L + A +EA+ + + T +E + + + +
Sbjct: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257
Query: 261 EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
A + QE ++ L + + AL +E Q VQ+ AE E + E +
Sbjct: 2258 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2317
Query: 318 LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
E+AR R + + + AQ +L+E +G R EA
Sbjct: 2318 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2348
Score = 28.5 bits (62), Expect = 9.8
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)
Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
EE Q +V DL + A+L R + +S+EE RA+ ERAR++ G+
Sbjct: 511 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 559
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 51.6 bits (122), Expect = 1e-06
Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)
Query: 150 GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
GE + R+++ +A E ERL++ + + S + Q E E + + + A +
Sbjct: 1459 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1518
Query: 205 EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
A A + R Q E ++AE ER RQ AEL+++ AS T +
Sbjct: 1519 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1578
Query: 249 EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
E +SL++ V +E + Q A E AERE + +++ E L+
Sbjct: 1579 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633
Query: 309 HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
+ A ++SL +A AE+++ AE R +L + L + +L EG A+
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1693
Query: 357 AEAA 360
AA
Sbjct: 1694 RLAA 1697
Score = 49.7 bits (117), Expect = 4e-06
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1693
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1694 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1744
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1745 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1783
Query: 283 EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
E E A R L E + Q + E RAE ER AE +G A +L
Sbjct: 1784 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1834
Query: 339 ---LDVSLFELSELREGLARLAE 358
+++L E E L RLAE
Sbjct: 1835 KTEAEIALKEKEAENERLRRLAE 1857
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2300 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2359
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2360 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2419
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479
Query: 266 T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
+ KD +Q + Q E L E + QQ ++ + + ++E + + + S+E
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2539
Query: 320 EARAERERARAEVGRAAQLL 339
EAR + A V R + L
Sbjct: 2540 EARRRQHEAEEGVRRKQEEL 2559
Score = 42.7 bits (99), Expect = 5e-04
Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)
Query: 151 EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
EE+L Q A+ ERERL ++ L+E + Q E E LQ ++
Sbjct: 1333 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1384
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
+ AA +QQ + + E ++LRQ +E E QA + E+ L + +
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1443
Query: 259 --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
QLEA + + + E+Q L+++ R+A E AER Q + + R AE+E
Sbjct: 1444 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1503
Query: 309 ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
L+A+E L+ AER +AEV RA Q+
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1549
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
AA + ++L+A+ EA RLR+R + L +AA + EK Q EQ L
Sbjct: 1992 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2051
Query: 261 EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
+ +Q + + L+ + R A E AE RE Q ++V++ E E Q
Sbjct: 2052 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111
Query: 312 RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
+A ++ A R+ A E R AQ +L
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2143
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
E ERLK+ E + Q +A L+ + A +A AA + +Q +A+ + ++
Sbjct: 2099 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2158
Query: 227 LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
++ +AQ E+T E Q +E+
Sbjct: 2159 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2218
Query: 264 VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
V+ + +E+ LK++ AL +++ TQ+ +Q+ + ++ + + + +EA
Sbjct: 2219 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2278
Query: 324 ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
R+ A ++ + L + L E + + RL AEA
Sbjct: 2279 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2315
Score = 39.3 bits (90), Expect = 0.006
Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E ARL RE + + LA + L+++ EE ++ +E+
Sbjct: 1720 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1771
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
+ + G E+ EA K L E +AA RQ+ EA+R AE+L
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1827
Query: 230 RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
+ +E+ EKE E+L L + + + + L+ Q + +E
Sbjct: 1828 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881
Query: 287 -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
A++ E +QK V+D + ++E ++ A++ S E+A A + E+GR
Sbjct: 1882 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1936
Score = 39.3 bits (90), Expect = 0.006
Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)
Query: 94 ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
A + L + AE E + RL + +Q ++ L + S L G E+
Sbjct: 1847 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1902
Query: 154 LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
L + + + E LK + + G+ + E E ++ + + +A AA+
Sbjct: 1903 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 214 RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
RQ + E +R EAE R R+ E + + A + E+E
Sbjct: 1959 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2018
Query: 251 -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
L Q + ++L+A VQ K+QE+ Q++ Q G EA A E
Sbjct: 2019 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2078
Query: 292 ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
+ +VQ E A+ Q+ ER L+++ E+ +ARA+ AA+ L E +
Sbjct: 2079 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2130
Query: 352 GLARLAEA 359
AR A+A
Sbjct: 2131 EAARRAQA 2138
Score = 32.7 bits (73), Expect = 0.52
Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
A+ ++V+EA RL ++ +++ + + A A + +A E+ L + Q+A
Sbjct: 2091 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2149
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
DA E E+ KK + + Q E E L+ + +L EA
Sbjct: 2150 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2205
Query: 207 NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
+Q ++L + R + E L + A +EA+ + + T +E + + + +
Sbjct: 2206 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265
Query: 261 EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
A + QE ++ L + + AL +E Q VQ+ AE E + E +
Sbjct: 2266 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2325
Query: 318 LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
E+AR R + + + AQ +L+E +G R EA
Sbjct: 2326 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2356
Score = 28.5 bits (62), Expect = 9.8
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)
Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
EE Q +V DL + A+L R + +S+EE RA+ ERAR++ G+
Sbjct: 519 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 567
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 51.6 bits (122), Expect = 1e-06
Identities = 61/244 (25%), Positives = 104/244 (42%), Gaps = 38/244 (15%)
Query: 150 GEEKLFRSQSADAPGPT-----ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALR 204
GE + R+++ +A E ERL++ + + S + Q E E + + + A +
Sbjct: 1500 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1559
Query: 205 EANAAAAQWRQQLEA-----QRAEAERLRQ-----------RVAELEAQAASEVTPTGEK 248
A A + R Q E ++AE ER RQ AEL+++ AS T +
Sbjct: 1560 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1619
Query: 249 EGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELE 308
E +SL++ V +E + Q A E AERE + +++ E L+
Sbjct: 1620 E-----RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674
Query: 309 HQLRAMERSLEEARAERERARAE------------VGRAAQLLDVSLFELSELREGLARL 356
+ A ++SL +A AE+++ AE R +L + L + +L EG A+
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1734
Query: 357 AEAA 360
AA
Sbjct: 1735 RLAA 1738
Score = 49.7 bits (117), Expect = 4e-06
Identities = 71/263 (26%), Positives = 105/263 (39%), Gaps = 46/263 (17%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADA 162
AE+ + K A+ EK ++ E + G A Q ++ +++ +A
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1734
Query: 163 PGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRA 222
E+E L ++ +E GE Q Q +LA REA AAA Q RQ+LEA+ A
Sbjct: 1735 RLAAEQE-LIRLRAETEQGEQQ-------RQLLEEELARLQREA-AAATQKRQELEAELA 1785
Query: 223 EAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPR 282
+ AE+E AS+ E T ++ Q L+++ G R
Sbjct: 1786 KVR------AEMEVLLASKARAEEESR---------------STSEKSKQRLEAEAGRFR 1824
Query: 283 EALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAE----VGRAAQL 338
E E A R L E + Q + E RAE ER AE +G A +L
Sbjct: 1825 ELAEEAAR---------LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1875
Query: 339 ---LDVSLFELSELREGLARLAE 358
+++L E E L RLAE
Sbjct: 1876 KTEAEIALKEKEAENERLRRLAE 1898
Score = 49.3 bits (116), Expect = 5e-06
Identities = 66/260 (25%), Positives = 110/260 (42%), Gaps = 24/260 (9%)
Query: 104 EKFQEVKEAARLAREKS--QDGGELTSP-ALGLASHQVPPSPLVSANGPGEEKLFRSQ-S 159
EK Q V+EA RL E Q EL A L + + ++ G ++ ++
Sbjct: 2341 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2400
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQ---WRQQ 216
E ERLK ++E S + + E + + ++ L A + Q
Sbjct: 2401 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2460
Query: 217 LEAQRAE----AERLRQRVAELEAQ-------AASEVTPTGEKEGLGQGQSLEQLEALVQ 265
LE QR + AERLR+ +AELE + A + E + + Q Q L++ +AL Q
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520
Query: 266 T----KDQEIQTLK--SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLE 319
+ KD +Q + Q E L E + QQ ++ + + ++E + + + S+E
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
Query: 320 EARAERERARAEVGRAAQLL 339
EAR + A V R + L
Sbjct: 2581 EARRRQHEAEEGVRRKQEEL 2600
Score = 42.7 bits (99), Expect = 5e-04
Identities = 62/226 (27%), Positives = 97/226 (42%), Gaps = 47/226 (20%)
Query: 151 EEKLFRSQSADAPGPTERERL---------KKMLSEGSV-GEVQWEAEFFALQDSNNKLA 200
EE+L Q A+ ERERL ++ L+E + Q E E LQ ++
Sbjct: 1374 EERLAEQQRAE-----ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ---RMQ 1425
Query: 201 GALREANAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLE-- 258
+ AA +QQ + + E ++LRQ +E E QA + E+ L + +
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQS-SEAEIQAKARQAEAAERSRLRIEEEIRVV 1484
Query: 259 --QLEALVQTK---DQEIQTLKSQT----GGPREALEAAEREETQQKVQDLETRNAELE- 308
QLEA + + + E+Q L+++ R+A E AER Q + + R AE+E
Sbjct: 1485 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1544
Query: 309 ---------------HQLRAMER-SLEEARAERERARAEVGRAAQL 338
L+A+E L+ AER +AEV RA Q+
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQV 1590
Score = 41.6 bits (96), Expect = 0.001
Identities = 42/152 (27%), Positives = 66/152 (43%), Gaps = 17/152 (11%)
Query: 209 AAAQWRQQLEAQRAEAERLRQRVAE-------LEAQAASEVTPTGEKEGLGQGQSLEQ-L 260
AA + ++L+A+ EA RLR+R + L +AA + EK Q EQ L
Sbjct: 2033 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2092
Query: 261 EALVQTKDQEIQTLKSQTGGPREALEAAE-------REETQ--QKVQDLETRNAELEHQL 311
+ +Q + + L+ + R A E AE RE Q ++V++ E E Q
Sbjct: 2093 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152
Query: 312 RAMERSLEEARAERERARAEVGRAAQLLDVSL 343
+A ++ A R+ A E R AQ +L
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2184
Score = 41.6 bits (96), Expect = 0.001
Identities = 43/217 (19%), Positives = 88/217 (40%), Gaps = 24/217 (11%)
Query: 167 ERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAER 226
E ERLK+ E + Q +A L+ + A +A AA + +Q +A+ + ++
Sbjct: 2140 EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2199
Query: 227 LRQRVAELEAQAASEVTP-----------------------TGEKEGLGQGQSLEQLEAL 263
++ +AQ E+T E Q +E+
Sbjct: 2200 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS 2259
Query: 264 VQTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARA 323
V+ + +E+ LK++ AL +++ TQ+ +Q+ + ++ + + + +EA
Sbjct: 2260 VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAAR 2319
Query: 324 ERERARAEVGRAAQLLDVSLFELSELREGLARL-AEA 359
R+ A ++ + L + L E + + RL AEA
Sbjct: 2320 LRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2356
Score = 39.3 bits (90), Expect = 0.006
Identities = 54/235 (22%), Positives = 97/235 (41%), Gaps = 28/235 (11%)
Query: 110 KEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
+E ARL RE + + LA + L+++ EE ++ +E+
Sbjct: 1761 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE--------ESRSTSEKS 1812
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
+ + G E+ EA K L E +AA RQ+ EA+R AE+L
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA----RQRAEAERVLAEKLAA 1868
Query: 230 RVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPREALE--- 286
+ +E+ EKE E+L L + + + + L+ Q + +E
Sbjct: 1869 IGEATRLKTEAEIA-LKEKEAEN-----ERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922
Query: 287 -----AAEREETQQK--VQDLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
A++ E +QK V+D + ++E ++ A++ S E+A A + E+GR
Sbjct: 1923 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1977
Score = 39.3 bits (90), Expect = 0.006
Identities = 72/308 (23%), Positives = 122/308 (39%), Gaps = 58/308 (18%)
Query: 94 ASEQHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK 153
A + L + AE E + RL + +Q ++ L + S L G E+
Sbjct: 1888 AENERLRRLAE--DEAFQRRRLEEQAAQHKADIEERLAQL--RKASDSELERQKGLVEDT 1943
Query: 154 LFRSQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQW 213
L + + + E LK + + G+ + E E ++ + + +A AA+
Sbjct: 1944 LRQRRQVEE----EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Query: 214 RQ---QLEAQRAEAE--------------RLRQRVAE------LEAQAASEVTPTGEKEG 250
RQ + E +R EAE R R+ E + + A + E+E
Sbjct: 2000 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQES 2059
Query: 251 -----LGQGQSLEQLEA-------LVQTKDQEI-------QTLKSQTGGPREALEAAERE 291
L Q + ++L+A VQ K+QE+ Q++ Q G EA A E
Sbjct: 2060 ARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE 2119
Query: 292 ETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLLDVSLFELSELRE 351
+ +VQ E A+ Q+ ER L+++ E+ +ARA+ AA+ L E +
Sbjct: 2120 AEEARVQ-AEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL------RKEAEQ 2171
Query: 352 GLARLAEA 359
AR A+A
Sbjct: 2172 EAARRAQA 2179
Score = 32.7 bits (73), Expect = 0.52
Identities = 62/282 (21%), Positives = 115/282 (40%), Gaps = 41/282 (14%)
Query: 103 AEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEK--LFRSQSA 160
A+ ++V+EA RL ++ +++ + + A A + +A E+ L + Q+A
Sbjct: 2132 AQSRRQVEEAERL-KQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190
Query: 161 DAPGPTERERLKKMLSEGSVGEVQWEAEFFALQ--------------DSNNKLAGALREA 206
DA E E+ KK + + Q E E L+ + +L EA
Sbjct: 2191 DA----EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2246
Query: 207 NAAAAQWRQQLEAQRAEAERLRQRVAELEAQAASEV------TPTGEKEGLGQGQSLEQL 260
+Q ++L + R + E L + A +EA+ + + T +E + + + +
Sbjct: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306
Query: 261 EALVQTKDQE---IQTLKSQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERS 317
A + QE ++ L + + AL +E Q VQ+ AE E + E +
Sbjct: 2307 AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2366
Query: 318 LEEARAERERARAEVGRAAQLLDVSLFELSELREGLARLAEA 359
E+AR R + + + AQ +L+E +G R EA
Sbjct: 2367 QEQAR----RLQEDKEQMAQ-------QLAEETQGFQRTLEA 2397
Score = 28.5 bits (62), Expect = 9.8
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 7/50 (14%)
Query: 291 EETQQKVQ------DLETRNAELEHQLRAMERSLEEARAERERARAEVGR 334
EE Q +V DL + A+L R + +S+EE RA+ ERAR++ G+
Sbjct: 560 EENQHRVDGAEWGVDLPSVEAQLGSH-RGLHQSIEEFRAKIERARSDEGQ 608
>gi|7706687 Enah/Vasp-like [Homo sapiens]
Length = 418
Score = 51.6 bits (122), Expect = 1e-06
Identities = 29/103 (28%), Positives = 55/103 (53%), Gaps = 8/103 (7%)
Query: 6 EQPIFSTRAHVFQIDPATKRNWIPA--GKHALT-VSYFYDATRNVYRIISIG--GAKAII 60
EQ I RA V D +K+ W+P G+ + ++ +++ N +R++ + + +I
Sbjct: 5 EQSICQARASVMVYDDTSKK-WVPIKPGQQGFSRINIYHNTASNTFRVVGVKLQDQQVVI 63
Query: 61 NSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQHLTQFA 103
N ++ + + + + F QW D+R VYGL FAS++ T F+
Sbjct: 64 NYSIVKGLKYNQATPTFHQWRDAR--QVYGLNFASKEEATTFS 104
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 51.6 bits (122), Expect = 1e-06
Identities = 63/241 (26%), Positives = 107/241 (44%), Gaps = 48/241 (19%)
Query: 162 APGPTERERLKKMLSE-----GSVGEVQWEAEFFALQDSNN---KLAGALREANAAAAQW 213
A G E+E L++ +++ ++G+ + EA+ L+ N +L+ L +A A A+
Sbjct: 721 ASGVAEQEALREEVAQLRRKAEALGD-ELEAQARKLEAQNTEAARLSKELAQARRAEAEA 779
Query: 214 RQQLEAQRAEAERLRQRV---------AELEAQAASEVTPTGEKEGLGQGQSLEQLEALV 264
++ EAQ E RLR+ V A E +A E +E + +L A
Sbjct: 780 HREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAGRERRQWEREGSRLRAQS 839
Query: 265 QTKDQEIQTLKSQTGGPREALEAAEREETQQKVQDLE-----TRNAELEHQLRAMERSLE 319
+ ++ +Q L+S+ R+ LE AERE +++ E R EL +L ++R LE
Sbjct: 840 EAAEERMQVLESEG---RQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELE 896
Query: 320 EARAER------------------ERARAEVGRAAQLLDVSLFELS----ELREGLARLA 357
+A ER +R AE+ AA + +L EL +L E L +L
Sbjct: 897 QAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLR 956
Query: 358 E 358
+
Sbjct: 957 Q 957
Score = 44.7 bits (104), Expect = 1e-04
Identities = 60/257 (23%), Positives = 104/257 (40%), Gaps = 35/257 (13%)
Query: 100 TQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQS 159
TQ + + A L EK+ G+L Q L S G +E L +SQ
Sbjct: 975 TQNVRLIEVERSNAMLVAEKAALQGQL----------QHLEGQLGSLQGRAQELLLQSQR 1024
Query: 160 ADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEA 219
A +E ++ +E SV E+Q + L+ ++ A + Q + L
Sbjct: 1025 A-------QEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRD 1077
Query: 220 QRAEAERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTG 279
+A A+ R++ AELE ++ ++LE +Q + +++Q ++
Sbjct: 1078 HKALAQLQRRQEAELEGLLVR------HRDLKANMRALELAHRELQGRHEQLQAQRASV- 1130
Query: 280 GPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQLL 339
EA E A E ++ +QD H+ R +E L ++E +RA+ + ++
Sbjct: 1131 ---EAQEVALLAERERLMQD--------GHRQRGLEEELRRLQSEHDRAQMLLAELSRER 1179
Query: 340 DVSLFELSELREGLARL 356
E ELR LARL
Sbjct: 1180 GELQGERGELRGRLARL 1196
Score = 43.9 bits (102), Expect = 2e-04
Identities = 49/181 (27%), Positives = 82/181 (45%), Gaps = 26/181 (14%)
Query: 176 SEGSVGEVQWE--------AEFFALQDS-NNKLAGALREANAAAAQWRQQ---LEAQRAE 223
SEG++ WE A A Q++ ++A R+A A + Q LEAQ E
Sbjct: 702 SEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTE 761
Query: 224 AERLRQRVAELEAQAASEVTPTGEKEGLGQGQSLEQLEALVQTKDQEIQTLKSQTGGPRE 283
A RL + +A+ A +E Q +L V+ QE+++ + E
Sbjct: 762 AARLSKELAQARRAEAE-----AHREAEAQAWEQARLREAVEAAGQELESASQEREALVE 816
Query: 284 ALEAA--EREETQQKVQDLETRNAELEHQLRAME----RSLEEA---RAERERARAEVGR 334
AL AA ER + +++ L ++ E +++ +E + LEEA R E+E +AE+ +
Sbjct: 817 ALAAAGRERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEK 876
Query: 335 A 335
A
Sbjct: 877 A 877
Score = 40.8 bits (94), Expect = 0.002
Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 14/243 (5%)
Query: 97 QHLTQFAEKFQEVKEAARLAREKSQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFR 156
QHL + AE+ + KEA + EK+ G+ L ++ + L E++
Sbjct: 855 QHLEE-AERERREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKE--- 910
Query: 157 SQSADAPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQ 216
SQ G +R + + S E E + ALQ LR+ A +++
Sbjct: 911 SQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQLEEELFQ--LRQGPAGLGP-KKR 967
Query: 217 LEAQRAEAERLRQRVAELEAQAASEVTPTGEKEGL-GQGQSLEQLEALVQTKDQEIQTLK 275
E Q E + +R + E+E A V EK L GQ Q LE +Q + QE+ L+
Sbjct: 968 AEPQLVETQNVR--LIEVERSNAMLVA---EKAALQGQLQHLEGQLGSLQGRAQEL-LLQ 1021
Query: 276 SQTGGPREALEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRA 335
SQ + AE+ + + Q+L + LE ++RA +S EE R +++ +
Sbjct: 1022 SQRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKAL 1081
Query: 336 AQL 338
AQL
Sbjct: 1082 AQL 1084
Score = 37.4 bits (85), Expect = 0.021
Identities = 57/230 (24%), Positives = 94/230 (40%), Gaps = 17/230 (7%)
Query: 113 ARLAREK---SQDGGELTSPALGLASHQVPPSPLVSANGPGEEKLFRSQSADAPGPTERE 169
++LARE+ +Q EL L PS A GP + +A A +
Sbjct: 214 SKLARERDLGAQRLAELLLEREPLCLRPEAPSR-APAEGPSHHLALQLANAKA----QLR 268
Query: 170 RLKKMLSEGSVGEVQWEAEFFALQDSNNKLAGALREANAAAAQWRQQLEAQRAEAERLRQ 229
RL++ L E + + +AE L+ +L +EA A + Q ++ E R EAE LR+
Sbjct: 269 RLRQELEEKAELLLDSQAEVQGLEAEIRRLR---QEAQALSGQ-AKRAELYREEAEALRE 324
Query: 230 RVAELEAQAASEVTPTGEKEGLGQG--QSLEQLEALVQTKDQEIQTLKSQTGGPREALEA 287
R L + E+ E+ + LE+ L + L+ Q RE
Sbjct: 325 RAGRL-PRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARE--RC 381
Query: 288 AEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQ 337
A ETQ++ L TR E +L ++ +++ E E+ R+ +
Sbjct: 382 ARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLE 431
Score = 31.6 bits (70), Expect = 1.2
Identities = 32/136 (23%), Positives = 50/136 (36%), Gaps = 29/136 (21%)
Query: 247 EKEGLGQGQSLEQLEALVQTKDQ----------------------EIQTLKSQTGGPREA 284
E+EG QG L +A + DQ E+Q + G A
Sbjct: 662 EQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLA 721
Query: 285 LEAAEREETQQKVQDLETRNAELEHQLRAMERSLEEARAERERARAEVGRAAQL------ 338
AE+E +++V L + L +L A R LE E R E+ +A +
Sbjct: 722 SGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHR 781
Query: 339 -LDVSLFELSELREGL 353
+ +E + LRE +
Sbjct: 782 EAEAQAWEQARLREAV 797
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.124 0.337
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,447,330
Number of Sequences: 37866
Number of extensions: 551269
Number of successful extensions: 6121
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 255
Number of HSP's successfully gapped in prelim test: 600
Number of HSP's that attempted gapping in prelim test: 3476
Number of HSP's gapped (non-prelim): 2352
length of query: 361
length of database: 18,247,518
effective HSP length: 104
effective length of query: 257
effective length of database: 14,309,454
effective search space: 3677529678
effective search space used: 3677529678
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.