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Search of human proteins with 224586793
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224586793 src homology 2 domain-containing transforming
protein C3 [Homo sapiens]
(594 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224586793 src homology 2 domain-containing transforming prote... 1199 0.0
gi|194239662 SHC (Src homology 2 domain containing) transforming... 500 e-141
gi|194239664 SHC (Src homology 2 domain containing) transforming... 499 e-141
gi|194239668 SHC (Src homology 2 domain containing) transforming... 484 e-137
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 484 e-136
gi|169790811 SHC (Src homology 2 domain containing) transforming... 461 e-129
gi|222446609 rai-like protein [Homo sapiens] 452 e-127
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 173 4e-43
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 66 8e-11
gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens] 61 3e-09
gi|242247193 SH2B adaptor protein 2 [Homo sapiens] 55 1e-07
gi|208609985 SH2 domain containing 3A [Homo sapiens] 55 2e-07
gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 54 3e-07
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens] 54 3e-07
gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens] 54 3e-07
gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 54 3e-07
gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens] 54 3e-07
gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 54 3e-07
gi|4503787 fyn-related kinase [Homo sapiens] 53 9e-07
gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens] 53 9e-07
gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens] 53 9e-07
gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens] 53 9e-07
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens] 53 9e-07
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 52 2e-06
gi|50511947 cajalin 2 isoform b [Homo sapiens] 52 2e-06
gi|50511945 cajalin 2 isoform a [Homo sapiens] 52 2e-06
gi|10047134 cajalin 2 isoform c [Homo sapiens] 52 2e-06
gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 51 3e-06
gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p5... 51 3e-06
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 50 8e-06
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 1199 bits (3102), Expect = 0.0
Identities = 594/594 (100%), Positives = 594/594 (100%)
Query: 1 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG 60
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG
Sbjct: 1 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAPDDG 60
Query: 61 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA 120
PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA
Sbjct: 61 PGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSAPSAPRAPA 120
Query: 121 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI 180
MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI
Sbjct: 121 MSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQI 180
Query: 181 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD 240
TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD
Sbjct: 181 TREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPD 240
Query: 241 SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA 300
SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA
Sbjct: 241 SKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQA 300
Query: 301 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL 360
FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL
Sbjct: 301 FELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRL 360
Query: 361 KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE 420
KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE
Sbjct: 361 KPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGE 420
Query: 421 APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP 480
APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP
Sbjct: 421 APTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP 480
Query: 481 VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ 540
VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ
Sbjct: 481 VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ 540
Query: 541 AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ 594
AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ
Sbjct: 541 AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ 594
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 500 bits (1287), Expect = e-141
Identities = 301/633 (47%), Positives = 380/633 (60%), Gaps = 98/633 (15%)
Query: 3 PRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP-DDGP 61
P+ KYN RN+S++S+++ G G +A L G L P DD P
Sbjct: 6 PKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLPGDDSP 55
Query: 62 GSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSA------PSA 115
+L ++S+L+L++ AG R GS P AA DG P +
Sbjct: 56 TTLCSFFPRMSNLRLANP------------AGGR-PGSKGEPGRAADDGEGIVGAAMPDS 102
Query: 116 PRAPAMSAARK-------------GRPGDEPLPR-------PPRGAPHASDQVLGPGVTY 155
P + K G+ G E R P RG H +D+V+GPGV+Y
Sbjct: 103 GPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSY 162
Query: 156 VVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGK 215
+V+Y+GC+EVL+SMR+LDF+TRTQ+TREAIS VCEAVPGAKGA ++RKP S+ LSSILG+
Sbjct: 163 LVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGR 222
Query: 216 SNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPV 275
SNL+FAGM I+LT+ST+SLNL D KQIIANHHM+SISFASGGDPDT +YVAYVAKDPV
Sbjct: 223 SNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPV 282
Query: 276 NRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEG 334
N+RACHILEC +GLAQDVI +IGQAFELRFKQYL+ P K+ HDRM D W EEE
Sbjct: 283 NQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEE 342
Query: 335 DGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQ 394
+ DH YYN P K PP GG +D RL+ A QT HLG T
Sbjct: 343 EPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQT---PSHLGATL----- 394
Query: 395 QTPLRQGSSDIYSTPEGKLHVAPTG--------EAPTYVNTQQIPPQ------AWPAAVS 440
P+ Q + PE + + P + P+YVN Q + A P +
Sbjct: 395 --PVGQ---PVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPA 449
Query: 441 SAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWY 500
S+PR DLFDMKPFEDAL+ V P M E+L+ E W+
Sbjct: 450 INGSAPR-DLFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPWF 489
Query: 501 QGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVF 560
G++SR+EAE LL+ +GDFLVR+STT PG +VLTG+ +GQ KHLLLVDPEG +RTKD F
Sbjct: 490 HGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRF 549
Query: 561 DSISHLINHHLESSLPIVSAGSELCLQQPVERK 593
+S+SHLI++H+++ LPI+SAGSELCLQQPVERK
Sbjct: 550 ESVSHLISYHMDNHLPIISAGSELCLQQPVERK 582
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 499 bits (1286), Expect = e-141
Identities = 301/634 (47%), Positives = 380/634 (59%), Gaps = 99/634 (15%)
Query: 3 PRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAAPYLVSGEALRKAP-DDGP 61
P+ KYN RN+S++S+++ G G +A L G L P DD P
Sbjct: 6 PKPKYNPLRNESLSSLEE--------GASGSTPPEELPSPSASSL--GPILPPLPGDDSP 55
Query: 62 GSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGSA------PSA 115
+L ++S+L+L++ AG R GS P AA DG P +
Sbjct: 56 TTLCSFFPRMSNLRLANP------------AGGR-PGSKGEPGRAADDGEGIVGAAMPDS 102
Query: 116 PRAPAMSAARK-------------GRPGDEPLPR-------PPRGAPHASDQVLGPGVTY 155
P + K G+ G E R P RG H +D+V+GPGV+Y
Sbjct: 103 GPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSY 162
Query: 156 VVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGK 215
+V+Y+GC+EVL+SMR+LDF+TRTQ+TREAIS VCEAVPGAKGA ++RKP S+ LSSILG+
Sbjct: 163 LVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGR 222
Query: 216 SNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPV 275
SNL+FAGM I+LT+ST+SLNL D KQIIANHHM+SISFASGGDPDT +YVAYVAKDPV
Sbjct: 223 SNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPV 282
Query: 276 NRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLD-EPWTEEEG 334
N+RACHILEC +GLAQDVI +IGQAFELRFKQYL+ P K+ HDRM D W EEE
Sbjct: 283 NQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEE 342
Query: 335 DGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGEDWQ 394
+ DH YYN P K PP GG +D RL+ A QT HLG T
Sbjct: 343 EPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQT---PSHLGATL----- 394
Query: 395 QTPLRQGSSDIYSTPEGKLHVAPTG---------EAPTYVNTQQIPPQ------AWPAAV 439
P+ Q + PE + + P + P+YVN Q + A P
Sbjct: 395 --PVGQ---PVGGDPEVRKQMPPPPPCPAGRELFDDPSYVNVQNLDKARQAVGGAGPPNP 449
Query: 440 SSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETW 499
+ S+PR DLFDMKPFEDAL+ V P M E+L+ E W
Sbjct: 450 AINGSAPR-DLFDMKPFEDALR-------------------VPPPPQSVSMAEQLRGEPW 489
Query: 500 YQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRV 559
+ G++SR+EAE LL+ +GDFLVR+STT PG +VLTG+ +GQ KHLLLVDPEG +RTKD
Sbjct: 490 FHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHR 549
Query: 560 FDSISHLINHHLESSLPIVSAGSELCLQQPVERK 593
F+S+SHLI++H+++ LPI+SAGSELCLQQPVERK
Sbjct: 550 FESVSHLISYHMDNHLPIISAGSELCLQQPVERK 583
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 484 bits (1246), Expect = e-137
Identities = 262/473 (55%), Positives = 324/473 (68%), Gaps = 48/473 (10%)
Query: 136 RPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGA 195
+P RG H +D+V+GPGV+Y+V+Y+GC+EVL+SMR+LDF+TRTQ+TREAIS VCEAVPGA
Sbjct: 33 KPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGA 92
Query: 196 KGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISF 255
KGA ++RKP S+ LSSILG+SNL+FAGM I+LT+ST+SLNL D KQIIANHHM+SISF
Sbjct: 93 KGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISF 152
Query: 256 ASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKI 315
ASGGDPDT +YVAYVAKDPVN+RACHILEC +GLAQDVI +IGQAFELRFKQYL+ P K+
Sbjct: 153 ASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKL 212
Query: 316 PALHDRMQSLD-EPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAG 374
HDRM D W EEE + DH YYN P K PP GG +D RL+ A
Sbjct: 213 VTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAP 272
Query: 375 KEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTG--------EAPTYVN 426
QT HLG T P+ Q + PE + + P + P+YVN
Sbjct: 273 NAQT---PSHLGATL-------PVGQ---PVGGDPEVRKQMPPPPPCPGRELFDDPSYVN 319
Query: 427 TQQIPPQ------AWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISP 480
Q + A P + S+PR DLFDMKPFEDAL+
Sbjct: 320 VQNLDKARQAVGGAGPPNPAINGSAPR-DLFDMKPFEDALR------------------- 359
Query: 481 VSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQ 540
V P M E+L+ E W+ G++SR+EAE LL+ +GDFLVR+STT PG +VLTG+ +GQ
Sbjct: 360 VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ 419
Query: 541 AKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERK 593
KHLLLVDPEG +RTKD F+S+SHLI++H+++ LPI+SAGSELCLQQPVERK
Sbjct: 420 PKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERK 472
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 484 bits (1245), Expect = e-136
Identities = 262/474 (55%), Positives = 324/474 (68%), Gaps = 49/474 (10%)
Query: 136 RPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGA 195
+P RG H +D+V+GPGV+Y+V+Y+GC+EVL+SMR+LDF+TRTQ+TREAIS VCEAVPGA
Sbjct: 33 KPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGA 92
Query: 196 KGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISF 255
KGA ++RKP S+ LSSILG+SNL+FAGM I+LT+ST+SLNL D KQIIANHHM+SISF
Sbjct: 93 KGATRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISF 152
Query: 256 ASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKI 315
ASGGDPDT +YVAYVAKDPVN+RACHILEC +GLAQDVI +IGQAFELRFKQYL+ P K+
Sbjct: 153 ASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKL 212
Query: 316 PALHDRMQSLD-EPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAG 374
HDRM D W EEE + DH YYN P K PP GG +D RL+ A
Sbjct: 213 VTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAP 272
Query: 375 KEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTG---------EAPTYV 425
QT HLG T P+ Q + PE + + P + P+YV
Sbjct: 273 NAQT---PSHLGATL-------PVGQ---PVGGDPEVRKQMPPPPPCPAGRELFDDPSYV 319
Query: 426 NTQQIPPQ------AWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASVECIS 479
N Q + A P + S+PR DLFDMKPFEDAL+
Sbjct: 320 NVQNLDKARQAVGGAGPPNPAINGSAPR-DLFDMKPFEDALR------------------ 360
Query: 480 PVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNG 539
V P M E+L+ E W+ G++SR+EAE LL+ +GDFLVR+STT PG +VLTG+ +G
Sbjct: 361 -VPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSG 419
Query: 540 QAKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERK 593
Q KHLLLVDPEG +RTKD F+S+SHLI++H+++ LPI+SAGSELCLQQPVERK
Sbjct: 420 QPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERK 473
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 461 bits (1185), Expect = e-129
Identities = 264/530 (49%), Positives = 330/530 (62%), Gaps = 35/530 (6%)
Query: 80 GLRGLSSAARERAGARLSGSCSAPSLA-----------APDGSAPSAPRAPAMSAARKGR 128
G+ L++A R + C P+L+ G+A S A A RKG
Sbjct: 71 GVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKG- 129
Query: 129 PGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAISRV 188
+ +P G H +VLGPGV+YVV+Y+GCIEVLRSMRSLDF+TRTQ+TREAI+R+
Sbjct: 130 ---SFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTREAINRL 186
Query: 189 CEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIIANH 248
EAVPG +G++KK K P+K L+S+LGKSNL+FAGMSIS+ IST L+L P ++Q+IANH
Sbjct: 187 HEAVPGVRGSWKK-KAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANH 245
Query: 249 HMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQY 308
HM SISFASGGD D TDYVAYVAKDP+N+RACHILECC+GLAQ +I ++GQAFELRFKQY
Sbjct: 246 HMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFELRFKQY 305
Query: 309 LQCPTKIPALHDRMQSLDEPWTEEEGDGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPD 368
L P K+ +R+ +E +E D +H YYNSIP K PP GG +D+RL
Sbjct: 306 LHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALTQPCAL 365
Query: 369 TAQFAGKEQTYYQGRHLGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQ 428
TA G + L G P G + + G P E YVNTQ
Sbjct: 366 TALDQGPSPSLRDACSLPWDVGSTGTAPP---GDGYVQADARG----PPDHEEHLYVNTQ 418
Query: 429 QIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASV-----ECISPVSP 483
+ E SP+KDLFDM+PFEDALK A+ + SP +
Sbjct: 419 GLD-------APEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTR 471
Query: 484 RAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKH 543
RAP A E+L+ E WY G MSR+ AE +L DGDFLVR S TNPG +VLTGMH GQ KH
Sbjct: 472 RAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKH 531
Query: 544 LLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERK 593
LLLVDPEG +RTKD +F+SISHLI+HHL++ PIV+A SEL L+ V R+
Sbjct: 532 LLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSRE 581
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 452 bits (1162), Expect = e-127
Identities = 278/633 (43%), Positives = 371/633 (58%), Gaps = 78/633 (12%)
Query: 1 MLPRTKYNRFRNDSVTSVDDLLHSLSVSGG--GGKVSAARATPAAAPYLVSGEALRKAPD 58
ML R KY+RFRN+S+TS+D+ SGG G K S PA AP+L + +A +
Sbjct: 24 MLHRAKYSRFRNESITSLDE-----GSSGGSVGNKGSPQPPHPALAPHLPTEDATLPS-Q 77
Query: 59 DGPGSLGHLLHKVSHLKLSSSG----LRGLSSAARERAGARL--------SGSCSAPSLA 106
+ P L L+ +++ +KL++ L+ +E +L SG S +
Sbjct: 78 ESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSL 137
Query: 107 APDGSAPSAPRAPAMSAARKGRPGDEPLPRP------PRGAPHASDQVLGPGVTYVVKYL 160
+ G+AP + A P PLP P R H +LG G+ Y V+Y+
Sbjct: 138 SRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRHFLQHLLGMGMNYCVRYM 197
Query: 161 GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQF 220
GC+EVL+SMRSLDF RTQ+TREAISR+CEAVPGA GA KKRKPP K LS++LGKSNLQF
Sbjct: 198 GCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVKFLSTVLGKSNLQF 257
Query: 221 AGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVNRRAC 280
+GM+I LTIST SL L D++QIIANHHM+SISFASGGDPDTTDYVAYVAKDPVN+RAC
Sbjct: 258 SGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRAC 317
Query: 281 HILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEGDGSDHP 340
HILEC +G+AQDVI +IGQAFELRFKQYL+ P+ + +D E E DH
Sbjct: 318 HILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDSHAEERE----DHE 373
Query: 341 YYNSIPSKMPPPGGFLDTRLKPRP---------------HAPDTAQFAG-KEQTYYQGRH 384
YYN IP K PP GG D R+K + + P ++ + E Q R
Sbjct: 374 YYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRA 433
Query: 385 LGDTFGEDWQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAES 444
+G+ Q ++ +S + T L + P Y+NTQ + Q+ P + + S
Sbjct: 434 IGNVHPRGVQS---QRDTSLLKHTCRVDLF-----DDPCYINTQAL--QSTPGSAGNQRS 483
Query: 445 SPRKDLFDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAK-----MLEELQAETW 499
+ QPLG + E + P + P + + ++L +E
Sbjct: 484 A-----------------QPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEEC 526
Query: 500 YQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRV 559
Y G++SRK AE LL KDGDFLVR+S T+PG +VL+G+ GQAKHLLLVDPEG +RTKD V
Sbjct: 527 YHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHV 586
Query: 560 FDSISHLINHHLESSLPIVSAGSELCLQQPVER 592
FD++ HLI +H+++SLPI+S+GSE+ L+QPV +
Sbjct: 587 FDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRK 619
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 173 bits (439), Expect = 4e-43
Identities = 96/182 (52%), Positives = 116/182 (63%), Gaps = 12/182 (6%)
Query: 417 PTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDLFDMKPFEDALKNQPLGPVLSKAASV- 475
P E YVNTQ + E SP+KDLFDM+PFEDALK A+
Sbjct: 300 PDHEEHLYVNTQGLD-------APEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPL 352
Query: 476 ----ECISPVSPRAPDAKMLEELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSF 531
+ SP + RAP A E+L+ E WY G MSR+ AE +L DGDFLVR S TNPG +
Sbjct: 353 PLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQY 412
Query: 532 VLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVE 591
VLTGMH GQ KHLLLVDPEG +RTKD +F+SISHLI+HHL++ PIV+A SEL L+ V
Sbjct: 413 VLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVS 472
Query: 592 RK 593
R+
Sbjct: 473 RE 474
Score = 54.3 bits (129), Expect = 3e-07
Identities = 31/58 (53%), Positives = 36/58 (62%), Gaps = 7/58 (12%)
Query: 129 PGDEPLPRPPRGAPHASDQVLGPGVTYVVKYLGCIEVLRSMRSLDFSTRTQITREAIS 186
P P PP PH S P + Y+GCIEVLRSMRSLDF+TRTQ+TR+A S
Sbjct: 224 PSTHPPTHPP--VPHPSTH---PSIH--PSYMGCIEVLRSMRSLDFNTRTQVTRDACS 274
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 66.2 bits (160), Expect = 8e-11
Identities = 34/99 (34%), Positives = 57/99 (57%), Gaps = 1/99 (1%)
Query: 494 LQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTI 553
L + WY G + R EA+ LL+K GDFLVR+S PG +VL+ +GQ +H ++ +
Sbjct: 455 LAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMY 514
Query: 554 RTKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVER 592
R + F +I LI+HH ++ +++ S + L P+ +
Sbjct: 515 RFEGTGFSNIPQLIDHHY-TTKQVITKKSGVVLLNPIPK 552
>gi|4502371 breast cancer antiestrogen resistance 3 [Homo sapiens]
Length = 825
Score = 61.2 bits (147), Expect = 3e-09
Identities = 38/110 (34%), Positives = 62/110 (56%), Gaps = 10/110 (9%)
Query: 492 EELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKH-------L 544
E+L++ WY G + R+ +E L+++DGDFLVR S ++PG+FVLT A+H L
Sbjct: 147 EDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVL 206
Query: 545 LLVDPEGTIRTKDRV--FDSISHLINHHLESSLPIVSAGSELCLQQPVER 592
L + ++ + + FDSI L+ ++ + PI S S + QP+ R
Sbjct: 207 RLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPI-SQQSGAIIFQPINR 255
>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
Length = 675
Score = 55.5 bits (132), Expect = 1e-07
Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 6/103 (5%)
Query: 486 PDAKMLEELQAETWYQGEMSRKEAEGLL-----EKDGDFLVRKSTTNPGSFVLTGMHNGQ 540
P+A+ EL W+ G +SR +A L+ G F++R+S T PG +VLT G+
Sbjct: 447 PEAEPELELSDYPWFHGTLSRVKAAQLVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGK 506
Query: 541 AKHL-LLVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS 582
AKHL L ++ G + F S+ ++ H +P+ S GS
Sbjct: 507 AKHLRLSLNGHGQCHVQHLWFQSVLDMLRHFHTHPIPLESGGS 549
>gi|208609985 SH2 domain containing 3A [Homo sapiens]
Length = 576
Score = 54.7 bits (130), Expect = 2e-07
Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 9/98 (9%)
Query: 492 EELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLV---- 547
E+L + WY G +SR++AE LL+++GDFLVR S + G+ V++ G A H +
Sbjct: 8 EDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVAL 67
Query: 548 -----DPEGTIRTKDRVFDSISHLINHHLESSLPIVSA 580
P + +D F SI L++ ++ P+ A
Sbjct: 68 RPRPGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQA 105
>gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 492 EELQAETWYQGEMSRKEAEGLLEKDGD-----FLVRKSTTNPGSFVLTGMHNGQAKHL-L 545
+ L W+ G +SR +A L+ G FLVR+S T G +VLT G+AKHL L
Sbjct: 520 QPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRL 579
Query: 546 LVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS 582
++ EG R + F SI ++ H +P+ S GS
Sbjct: 580 SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
Length = 845
Score = 54.3 bits (129), Expect = 3e-07
Identities = 30/106 (28%), Positives = 53/106 (50%), Gaps = 3/106 (2%)
Query: 492 EELQAETWYQGEMSRKEAEGLL--EKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDP 549
++L WY G M R AE +L DG FLVR+ + F ++ +N + KH+ ++
Sbjct: 664 QDLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTA 723
Query: 550 EGTIR-TKDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ 594
EG R T+ + F ++ L+ + ++SL + LQ P + +
Sbjct: 724 EGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPE 769
>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
Length = 683
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 492 EELQAETWYQGEMSRKEAEGLLEKDGD-----FLVRKSTTNPGSFVLTGMHNGQAKHL-L 545
+ L W+ G +SR +A L+ G FLVR+S T G +VLT G+AKHL L
Sbjct: 520 QPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRL 579
Query: 546 LVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS 582
++ EG R + F SI ++ H +P+ S GS
Sbjct: 580 SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 492 EELQAETWYQGEMSRKEAEGLLEKDGD-----FLVRKSTTNPGSFVLTGMHNGQAKHL-L 545
+ L W+ G +SR +A L+ G FLVR+S T G +VLT G+AKHL L
Sbjct: 520 QPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRL 579
Query: 546 LVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS 582
++ EG R + F SI ++ H +P+ S GS
Sbjct: 580 SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]
Length = 756
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 492 EELQAETWYQGEMSRKEAEGLLEKDGD-----FLVRKSTTNPGSFVLTGMHNGQAKHL-L 545
+ L W+ G +SR +A L+ G FLVR+S T G +VLT G+AKHL L
Sbjct: 520 QPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRL 579
Query: 546 LVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS 582
++ EG R + F SI ++ H +P+ S GS
Sbjct: 580 SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 54.3 bits (129), Expect = 3e-07
Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 492 EELQAETWYQGEMSRKEAEGLLEKDGD-----FLVRKSTTNPGSFVLTGMHNGQAKHL-L 545
+ L W+ G +SR +A L+ G FLVR+S T G +VLT G+AKHL L
Sbjct: 520 QPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRL 579
Query: 546 LVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS 582
++ EG R + F SI ++ H +P+ S GS
Sbjct: 580 SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 52.8 bits (125), Expect = 9e-07
Identities = 28/87 (32%), Positives = 48/87 (55%), Gaps = 6/87 (6%)
Query: 494 LQAETWYQGEMSRKEAEGLL----EKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLL--V 547
LQAE W+ G + R +AE L K G FL+R+S + G F L+ + KH + +
Sbjct: 111 LQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRL 170
Query: 548 DPEGTIRTKDRVFDSISHLINHHLESS 574
D G T+ R+F +++ ++H+ ++S
Sbjct: 171 DEGGFFLTRRRIFSTLNEFVSHYTKTS 197
>gi|216547801 SH2 domain containing 3C isoform e [Homo sapiens]
Length = 700
Score = 52.8 bits (125), Expect = 9e-07
Identities = 35/109 (32%), Positives = 55/109 (50%), Gaps = 10/109 (9%)
Query: 493 ELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLL---VDP 549
+L++ WY G + R+ +E L++++GDFL+R S T+ G +VLT QA H + V
Sbjct: 54 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 113
Query: 550 EGTIRT------KDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVER 592
G T + FD + L+ +H+ S VS S + PV R
Sbjct: 114 AGESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 161
>gi|216547790 SH2 domain containing 3C isoform d [Homo sapiens]
Length = 702
Score = 52.8 bits (125), Expect = 9e-07
Identities = 35/109 (32%), Positives = 55/109 (50%), Gaps = 10/109 (9%)
Query: 493 ELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLL---VDP 549
+L++ WY G + R+ +E L++++GDFL+R S T+ G +VLT QA H + V
Sbjct: 56 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 115
Query: 550 EGTIRT------KDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVER 592
G T + FD + L+ +H+ S VS S + PV R
Sbjct: 116 AGESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 163
>gi|216547763 SH2 domain containing 3C isoform b [Homo sapiens]
Length = 703
Score = 52.8 bits (125), Expect = 9e-07
Identities = 35/109 (32%), Positives = 55/109 (50%), Gaps = 10/109 (9%)
Query: 493 ELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLL---VDP 549
+L++ WY G + R+ +E L++++GDFL+R S T+ G +VLT QA H + V
Sbjct: 57 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 116
Query: 550 EGTIRT------KDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVER 592
G T + FD + L+ +H+ S VS S + PV R
Sbjct: 117 AGESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 164
>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
Length = 860
Score = 52.8 bits (125), Expect = 9e-07
Identities = 35/109 (32%), Positives = 55/109 (50%), Gaps = 10/109 (9%)
Query: 493 ELQAETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLL---VDP 549
+L++ WY G + R+ +E L++++GDFL+R S T+ G +VLT QA H + V
Sbjct: 214 DLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVK 273
Query: 550 EGTIRT------KDRVFDSISHLINHHLESSLPIVSAGSELCLQQPVER 592
G T + FD + L+ +H+ S VS S + PV R
Sbjct: 274 AGESYTHIQYLFEQESFDHVPALVRYHV-GSRKAVSEQSGAIIYCPVNR 321
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 15/109 (13%)
Query: 496 AETWYQGEMSRKEAEGLLE---KDGDFLVRKSTTNPGSFVL---TGMHNGQAKHLLLVDP 549
+E W+ G +S KEAE LL K G FLVR+S ++PG FVL TG G++
Sbjct: 109 SERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVT 168
Query: 550 EGTIRTKD--------RVFDSISHLINHHLESSLPIVSAGSELCLQQPV 590
IR ++ FDS++ L+ H+ ++ + + + G+ L L+QP+
Sbjct: 169 HVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPM-VETLGTVLQLKQPL 216
Score = 39.7 bits (91), Expect = 0.008
Identities = 20/54 (37%), Positives = 28/54 (51%), Gaps = 3/54 (5%)
Query: 494 LQAETWYQGEMSRKEAEGLLEK---DGDFLVRKSTTNPGSFVLTGMHNGQAKHL 544
+ + W+ ++ EAE LL DG FL R S +NPG F L+ NG H+
Sbjct: 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHI 54
>gi|50511947 cajalin 2 isoform b [Homo sapiens]
Length = 510
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/89 (35%), Positives = 50/89 (56%), Gaps = 3/89 (3%)
Query: 224 SISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKD-PVNRRACHI 282
+I L++S + +K IIA H +R+IS A+ DP+ AY+ KD N CH+
Sbjct: 354 TIILSVSYKGVKFIDATNKNIIAEHEIRNISCAA-QDPEDLSTFAYITKDLKSNHHYCHV 412
Query: 283 LECCD-GLAQDVIGSIGQAFELRFKQYLQ 310
D LA ++I ++GQAFE+ ++ LQ
Sbjct: 413 FTAFDVNLAYEIILTLGQAFEVAYQLALQ 441
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/89 (35%), Positives = 50/89 (56%), Gaps = 3/89 (3%)
Query: 224 SISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKD-PVNRRACHI 282
+I L++S + +K IIA H +R+IS A+ DP+ AY+ KD N CH+
Sbjct: 1104 TIILSVSYKGVKFIDATNKNIIAEHEIRNISCAA-QDPEDLSTFAYITKDLKSNHHYCHV 1162
Query: 283 LECCD-GLAQDVIGSIGQAFELRFKQYLQ 310
D LA ++I ++GQAFE+ ++ LQ
Sbjct: 1163 FTAFDVNLAYEIILTLGQAFEVAYQLALQ 1191
>gi|10047134 cajalin 2 isoform c [Homo sapiens]
Length = 414
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/89 (35%), Positives = 50/89 (56%), Gaps = 3/89 (3%)
Query: 224 SISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKD-PVNRRACHI 282
+I L++S + +K IIA H +R+IS A+ DP+ AY+ KD N CH+
Sbjct: 270 TIILSVSYKGVKFIDATNKNIIAEHEIRNISCAA-QDPEDLSTFAYITKDLKSNHHYCHV 328
Query: 283 LECCD-GLAQDVIGSIGQAFELRFKQYLQ 310
D LA ++I ++GQAFE+ ++ LQ
Sbjct: 329 FTAFDVNLAYEIILTLGQAFEVAYQLALQ 357
>gi|166795247 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 50.8 bits (120), Expect = 3e-06
Identities = 36/105 (34%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 494 LQAETWYQGEMSRKEAEGLLEK--DGDFLVRKSTTN-PGSFVLTGMHNGQAKHLLLVDPE 550
LQ WY G++SR+E L DG FLVR ++T G + LT G K + + +
Sbjct: 60 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRD 119
Query: 551 GTIRTKDRV-FDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ 594
G D + F+S+ LINH+ SL + ++ L PV R Q
Sbjct: 120 GKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQ 164
Score = 38.1 bits (87), Expect = 0.023
Identities = 23/89 (25%), Positives = 48/89 (53%), Gaps = 5/89 (5%)
Query: 491 LEELQAETWYQGEMSRKEAEGLL--EKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVD 548
L +TW+ +++R +AE LL + DG FL+R+S + G + + + +G+ KH ++
Sbjct: 350 LPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRES-SKKGCYACSVVADGEVKHCVIYS 408
Query: 549 PEGTIRTKD--RVFDSISHLINHHLESSL 575
+ ++ S+ L+ H+ ++SL
Sbjct: 409 TARGYGFAEPYNLYSSLKELVLHYQQTSL 437
>gi|166795245 phosphoinositide-3-kinase, regulatory subunit 3 (p55,
gamma) [Homo sapiens]
Length = 461
Score = 50.8 bits (120), Expect = 3e-06
Identities = 36/105 (34%), Positives = 52/105 (49%), Gaps = 4/105 (3%)
Query: 494 LQAETWYQGEMSRKEAEGLLEK--DGDFLVRKSTTN-PGSFVLTGMHNGQAKHLLLVDPE 550
LQ WY G++SR+E L DG FLVR ++T G + LT G K + + +
Sbjct: 60 LQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRD 119
Query: 551 GTIRTKDRV-FDSISHLINHHLESSLPIVSAGSELCLQQPVERKQ 594
G D + F+S+ LINH+ SL + ++ L PV R Q
Sbjct: 120 GKYGFSDPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQ 164
Score = 38.1 bits (87), Expect = 0.023
Identities = 23/89 (25%), Positives = 48/89 (53%), Gaps = 5/89 (5%)
Query: 491 LEELQAETWYQGEMSRKEAEGLL--EKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVD 548
L +TW+ +++R +AE LL + DG FL+R+S + G + + + +G+ KH ++
Sbjct: 350 LPHYDEKTWFVEDINRVQAEDLLYGKPDGAFLIRES-SKKGCYACSVVADGEVKHCVIYS 408
Query: 549 PEGTIRTKD--RVFDSISHLINHHLESSL 575
+ ++ S+ L+ H+ ++SL
Sbjct: 409 TARGYGFAEPYNLYSSLKELVLHYQQTSL 437
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 49.7 bits (117), Expect = 8e-06
Identities = 30/96 (31%), Positives = 49/96 (51%), Gaps = 5/96 (5%)
Query: 486 PDAKMLEELQA----ETWYQGEMSRKEAEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQA 541
P +++ E+Q + WY G + R E LL GDFLVR+S +VL+ + +G
Sbjct: 385 PPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRES-QGKQEYVLSVLWDGLP 443
Query: 542 KHLLLVDPEGTIRTKDRVFDSISHLINHHLESSLPI 577
+H ++ + R + F SI LI+H L + P+
Sbjct: 444 RHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPL 479
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,717,404
Number of Sequences: 37866
Number of extensions: 1451508
Number of successful extensions: 6705
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 308
Number of HSP's that attempted gapping in prelim test: 6014
Number of HSP's gapped (non-prelim): 865
length of query: 594
length of database: 18,247,518
effective HSP length: 108
effective length of query: 486
effective length of database: 14,157,990
effective search space: 6880783140
effective search space used: 6880783140
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.