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Search of human proteins with 221316695
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221316695 multimerin 2 precursor [Homo sapiens]
(949 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221316695 multimerin 2 precursor [Homo sapiens] 1882 0.0
gi|5901944 elastin microfibril interfacer 1 [Homo sapiens] 98 3e-20
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 86 2e-16
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 86 2e-16
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 86 2e-16
gi|45269141 multimerin 1 [Homo sapiens] 86 2e-16
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 74 5e-13
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 73 1e-12
gi|60498978 elastin microfibril interfacer 2 [Homo sapiens] 69 2e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 64 9e-10
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 64 9e-10
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 64 9e-10
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 64 9e-10
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 64 9e-10
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 64 9e-10
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 64 9e-10
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 64 9e-10
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 64 9e-10
gi|45433501 elastin microfibril interfacer 3 [Homo sapiens] 64 9e-10
gi|21735548 centrosomal protein 2 [Homo sapiens] 62 3e-09
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 62 3e-09
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 61 4e-09
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 61 4e-09
gi|16262452 cingulin [Homo sapiens] 59 2e-08
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 58 4e-08
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens] 58 4e-08
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 57 6e-08
gi|21389505 janus kinase and microtubule interacting protein 1 i... 57 6e-08
gi|150456473 janus kinase and microtubule interacting protein 1 ... 57 6e-08
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 57 6e-08
>gi|221316695 multimerin 2 precursor [Homo sapiens]
Length = 949
Score = 1882 bits (4875), Expect = 0.0
Identities = 949/949 (100%), Positives = 949/949 (100%)
Query: 1 MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPY 60
MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPY
Sbjct: 1 MILSLLFSLGGPLGWGLLGAWAQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPY 60
Query: 61 PMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWR 120
PMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWR
Sbjct: 61 PMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWR 120
Query: 121 CCPGYTGPNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQEHL 180
CCPGYTGPNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQEHL
Sbjct: 121 CCPGYTGPNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQEHL 180
Query: 181 LGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVH 240
LGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVH
Sbjct: 181 LGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVH 240
Query: 241 FSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQEN 300
FSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQEN
Sbjct: 241 FSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQEN 300
Query: 301 TQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGA 360
TQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGA
Sbjct: 301 TQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGA 360
Query: 361 GARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESD 420
GARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESD
Sbjct: 361 GARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESD 420
Query: 421 ETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQG 480
ETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQG
Sbjct: 421 ETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQG 480
Query: 481 GHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAV 540
GHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAV
Sbjct: 481 GHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAV 540
Query: 541 DAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALL 600
DAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALL
Sbjct: 541 DAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALL 600
Query: 601 EDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAA 660
EDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAA
Sbjct: 601 EDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAA 660
Query: 661 RVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAG 720
RVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAG
Sbjct: 661 RVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAG 720
Query: 721 AGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRK 780
AGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRK
Sbjct: 721 AGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRK 780
Query: 781 GKKQQKDLEAPRKRDKKEAEPLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQ 840
GKKQQKDLEAPRKRDKKEAEPLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQ
Sbjct: 781 GKKQQKDLEAPRKRDKKEAEPLVDIRVTGPVPGALGAALWEAGSPVAFYASFSEGTAALQ 840
Query: 841 TVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTT 900
TVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTT
Sbjct: 841 TVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTGQLVFGGHHRTPVCTT 900
Query: 901 GQGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLMFKT 949
GQGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLMFKT
Sbjct: 901 GQGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLMFKT 949
>gi|5901944 elastin microfibril interfacer 1 [Homo sapiens]
Length = 1016
Score = 98.2 bits (243), Expect = 3e-20
Identities = 224/1006 (22%), Positives = 349/1006 (34%), Gaps = 167/1006 (16%)
Query: 55 RNWCPYPMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVL 114
RNWC Y +++ V+ + E ++ + QPC G P C + +MYR +P Y+V K +
Sbjct: 57 RNWCAYVVTRTVSCVLEDGVETYVKY--QPCAWGQPQCPQ-SIMYRRFLRPRYRVAYKTV 113
Query: 115 TSLAWRCCPGYTGPNCEHHDSMA----------IPEPADP---GDSHQEPQDGPVSFKPG 161
T + WRCC GY G +C + A + PA P G S P G PG
Sbjct: 114 TDMEWRCCQGYGGDDCAESPAPALGPASSTPRPLARPARPNLSGSSAGSPLSGLGGEGPG 173
Query: 162 HLAAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFP 221
+V+ +EQ + L +LQ L G+ + L G L V A +T
Sbjct: 174 E----SEKVQQLEEQVQSLTKELQ--------GLRGVLQGLSGRLAEDVQRAVETAFNGR 221
Query: 222 DRSLEQVLLPHV-DTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSA 280
+ + P V +T ++ S H N ++ ++
Sbjct: 222 QQPADAAARPGVHETLNEIQHQLQLLDTRVSTHDQELGHLNNHHGGSSSSGGSRAPAPAS 281
Query: 281 VARADFQELGAKFEAKVQENTQRV-----GQLRQDVEDRLHAQHFTLHRSISELQADVDT 335
+EL + E ++QE+ G RQ EDR R++ +L A V+
Sbjct: 282 APPGPSEELLRQLEQRLQESCSVCLAGLDGFRRQQQEDRERL------RAMEKLLASVEE 335
Query: 336 KLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNL----SELHMTTARRE 391
+ + H A A G +P G RL +L+R L + + + RR
Sbjct: 336 RQR--HLAGLAVGRRPPQECCSPELG---------RRLAELERRLDVVAGSVTVLSGRRG 384
Query: 392 EEL-----------QYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEE-LQVN 439
EL YT + + L+R D S+E + + L
Sbjct: 385 TELGGAAGQGGHPPGYT--SLASRLSRLEDRFNSTLGPSEEQEESWPGAPGGLSHWLPAA 442
Query: 440 HTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYL 499
L +L +L S + + +E Q+ L G +D ++
Sbjct: 443 RGRLEQLGGLLANVSGELGGRLDLLEEQVAGAMQACGQLCSGAPG----EQDSQVSEILS 498
Query: 500 DLD---VIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGER 556
L+ + EGQ + T + E RQ ++L+ LQ V + VD A+ E
Sbjct: 499 ALERRVLDSEGQLRLVGSGLHTVEAAGEARQ---ATLEGLQEVVGRLQDRVD---AQDET 552
Query: 557 ARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGE 616
A T RL L G L+A E + L + R L G
Sbjct: 553 AAEFTLRLNLTAARLGQLEGLLQAHGDEGCGACGGVQEELGRLRDGVERCSCPLLPPRGP 612
Query: 617 EVLEEMSEQTPGPLP------------------------LSYEQIRVALQDAASGLQEQA 652
+ + GPL LS+ + +L + + ++ Q
Sbjct: 613 GAGPGVGGPSRGPLDGFSVFGGSSGSALQALQGELSEVILSFSSLNDSLNELQTTVEGQG 672
Query: 653 -----LG--WDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLS 705
LG D + + + L+Q + EH S + R A AG L+
Sbjct: 673 ADLADLGATKDRIISEINRLQQEA-----TEHATESEERFRGLEEGQAQAGQCPSLEGRL 727
Query: 706 NDVKNVGRCCEAEAGAGAA---SLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLM 762
++ V + AG L+ + GL L T + + L L G GL
Sbjct: 728 GRLEGVCERLDTVAGGLQGLREGLSRHVAGLWAGLRETNTTSQMQAALLEKLVGGQAGLG 787
Query: 763 EANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAEPLVDIRVTGP-----VPGALGA 817
+L+ LQ + R + KDL P EA P + GP PG+ G
Sbjct: 788 RRLGALN-SSLQLLEDRLHQLSLKDLTGP----AGEAGPPGPPGLQGPPGPAGPPGSPGK 842
Query: 818 ALWEA--------------GSP------VAFYASFSEGTAALQTVKFNTTYINIGSSYFP 857
E G+P VAF A+ S + TV F+ +N G Y P
Sbjct: 843 DGQEGPIGPPGPQGEQGVEGAPAAPVPQVAFSAALSLPRSEPGTVPFDRVLLNDGGYYDP 902
Query: 858 EHGYFRAPERGVYLFAV-----------SVEFGPGPGTGQLVFGGH-----HRTPVCTTG 901
E G F AP G YL + +V G ++ GG+ PV +
Sbjct: 903 ETGVFTAPLAGRYLLSAVLTGHRHEKVEAVLSRSNQGVARVDSGGYEPEGLENKPVAESQ 962
Query: 902 QGSGSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAFGGFLMF 947
G+ + LQ G+ V +L G + T F G L++
Sbjct: 963 PSPGTLGVFSLILPLQAGDTVCVDLVMGQLAHSEEPLTIFSGALLY 1008
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 85.5 bits (210), Expect = 2e-16
Identities = 161/677 (23%), Positives = 272/677 (40%), Gaps = 97/677 (14%)
Query: 164 AAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDR 223
A + +V+ Q+Q +G+LQ V ++ + L + L EA +T R
Sbjct: 883 AQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA-EAEETRGRLAAR 941
Query: 224 SLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVAR 283
E L+ R L Q I+ L +EA A ++Q + +
Sbjct: 942 KQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQ---LEK 998
Query: 284 ADFQELGAKFEAKV---QENTQRVGQLRQDVEDRLH------AQHFTLHRSISELQ---- 330
+ KFE + ++ ++ + R+ +EDRL A+ +S+++L+
Sbjct: 999 VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1058
Query: 331 ---ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTT 387
AD++ +L++ K ++ L E LQ ++ + Q+ EL
Sbjct: 1059 ATIADMEDRLRKEEKGRQE--------LEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1110
Query: 388 ARREEELQYTL---ED---MRATLTRHVDEIKELYSESDETFDQ----ISKVERQVEELQ 437
R+EEELQ L ED RA L + + E + +E+ E + +K E+Q +L
Sbjct: 1111 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1170
Query: 438 VNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKL 497
ALR ++ + +E + + E+++ EL TL+ H ++ ++ + Q L
Sbjct: 1171 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1230
Query: 498 YLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERA 557
+L E R A E+T+++L+ + L +LQ A + EGE+
Sbjct: 1231 G-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTA-----------RQEGEQR 1278
Query: 558 RAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEE 617
R RL Q+Q + G + A AEA ++++ + E
Sbjct: 1279 R---RRLELQLQEVQGRAGDGERARAEAAEKLQRAQAEL-------------------EN 1316
Query: 618 VLEEMSEQTPGPLPLSYE--QIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPA 675
V ++E + LS E L DA LQE+ L +RV A+E +E
Sbjct: 1317 VSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME--AEAAGLR 1374
Query: 676 EHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHN 735
E LE EEAA AG RELQ+ + R E EAGA A A
Sbjct: 1375 EQLE-------EEAAARERAG--RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1425
Query: 736 ALFATQRSLEQHQRLFHSLFGNFQGLMEA-NVSLDLGKLQTMLSRKGKKQQK-------- 786
A TQR E+ + + G + E + ++DL + + ++S KKQ+K
Sbjct: 1426 AEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEE 1485
Query: 787 ---DLEAPRKRDKKEAE 800
L A +R++ EAE
Sbjct: 1486 KAAVLRAVEERERAEAE 1502
Score = 46.6 bits (109), Expect = 1e-04
Identities = 88/356 (24%), Positives = 150/356 (42%), Gaps = 49/356 (13%)
Query: 290 GAKFEAKVQENTQRVGQLRQDVEDRLH---AQHFTLHRSISELQADVDTKLKRLHKAQEA 346
G + A+ E QR ++V L+ ++ L + +S +A + + L + A
Sbjct: 1296 GERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRA 1355
Query: 347 PGTNGSLVLA--TPGAGARP---EPDSLQARLG-QLQRNLSELHMTTARREEELQYTL-- 398
GS V A AG R E + + R G +LQ ++L R+EEE
Sbjct: 1356 KLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG 1415
Query: 399 EDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIME 458
E+ R R + + + +E ET D++ + R++++ EL M+
Sbjct: 1416 EEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ---------ELDDATMDL----- 1461
Query: 459 ENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREG-QRDA-----T 512
E +RQL+ TL+ Q L+ K + + EG +R+A T
Sbjct: 1462 ----EQQRQLVS---TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1514
Query: 513 RALEETQVSLDERRQLDGS---SLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQ 569
RALEE Q + +E + + + L+AL ++ D V +V + A A + LR+QV
Sbjct: 1515 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1574
Query: 570 ALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQ 625
L+DE+ A + A V+ L + L+ R EA GEE ++++Q
Sbjct: 1575 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQG--RDEA------GEERRRQLAKQ 1622
Score = 39.7 bits (91), Expect = 0.013
Identities = 93/471 (19%), Positives = 185/471 (39%), Gaps = 77/471 (16%)
Query: 250 QSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQ 309
+S+H L +A R R ++ ++D A D AK +V + Q +
Sbjct: 1550 KSVHELERACRVAEQAANDLRAQVTELEDELTAAED-----AKLRLEVTVQALKT-QHER 1603
Query: 310 DVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSL 369
D++ R A + +L+ D +++R + ++ T AR + L
Sbjct: 1604 DLQGRDEAGEERRRQLAKQLR---DAEVERDEERKQR----------TLAVAARKK---L 1647
Query: 370 QARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKV 429
+ L +L+ ++ + + +EE L M+A + E++E + +E F Q +
Sbjct: 1648 EGELEELKAQMA----SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES 1703
Query: 430 ERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYV 489
E++++ L+ L+E +++++E+ ++ NL+
Sbjct: 1704 EKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKA------------- 1750
Query: 490 KDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERR---QLDGSSLQALQNAVDAVSLA 546
I E +R L + + L+E + +L + L V++++
Sbjct: 1751 -------------AILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTE 1797
Query: 547 VDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE--VRQLHSAFAALLEDAL 604
+ A ++ +A + +L Q+Q L +G + A A ARH+ + L S A E+ L
Sbjct: 1798 LSAERSFSAKAESGRQQLERQIQELRGRLGE-EDAGARARHKMTIAALESKLAQ-AEEQL 1855
Query: 605 RHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTA 664
E L G+ L +E+ + L E+ R L++ L +L +
Sbjct: 1856 EQETRERILSGK--LVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQ--- 1910
Query: 665 LEQASEPPRPAEHLEPSHDAGRE------EAATTALAGLARELQSLSNDVK 709
LE+A E A+ AGR E T + + RE+ +L N ++
Sbjct: 1911 LEEAEEEASRAQ-------AGRRRLQRELEDVTESAESMNREVTTLRNRLR 1954
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 85.5 bits (210), Expect = 2e-16
Identities = 161/677 (23%), Positives = 272/677 (40%), Gaps = 97/677 (14%)
Query: 164 AAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDR 223
A + +V+ Q+Q +G+LQ V ++ + L + L EA +T R
Sbjct: 875 AQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA-EAEETRGRLAAR 933
Query: 224 SLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVAR 283
E L+ R L Q I+ L +EA A ++Q + +
Sbjct: 934 KQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQ---LEK 990
Query: 284 ADFQELGAKFEAKV---QENTQRVGQLRQDVEDRLH------AQHFTLHRSISELQ---- 330
+ KFE + ++ ++ + R+ +EDRL A+ +S+++L+
Sbjct: 991 VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1050
Query: 331 ---ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTT 387
AD++ +L++ K ++ L E LQ ++ + Q+ EL
Sbjct: 1051 ATIADMEDRLRKEEKGRQE--------LEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1102
Query: 388 ARREEELQYTL---ED---MRATLTRHVDEIKELYSESDETFDQ----ISKVERQVEELQ 437
R+EEELQ L ED RA L + + E + +E+ E + +K E+Q +L
Sbjct: 1103 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1162
Query: 438 VNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKL 497
ALR ++ + +E + + E+++ EL TL+ H ++ ++ + Q L
Sbjct: 1163 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1222
Query: 498 YLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERA 557
+L E R A E+T+++L+ + L +LQ A + EGE+
Sbjct: 1223 G-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTA-----------RQEGEQR 1270
Query: 558 RAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEE 617
R RL Q+Q + G + A AEA ++++ + E
Sbjct: 1271 R---RRLELQLQEVQGRAGDGERARAEAAEKLQRAQAEL-------------------EN 1308
Query: 618 VLEEMSEQTPGPLPLSYE--QIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPA 675
V ++E + LS E L DA LQE+ L +RV A+E +E
Sbjct: 1309 VSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME--AEAAGLR 1366
Query: 676 EHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHN 735
E LE EEAA AG RELQ+ + R E EAGA A A
Sbjct: 1367 EQLE-------EEAAARERAG--RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1417
Query: 736 ALFATQRSLEQHQRLFHSLFGNFQGLMEA-NVSLDLGKLQTMLSRKGKKQQK-------- 786
A TQR E+ + + G + E + ++DL + + ++S KKQ+K
Sbjct: 1418 AEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEE 1477
Query: 787 ---DLEAPRKRDKKEAE 800
L A +R++ EAE
Sbjct: 1478 KAAVLRAVEERERAEAE 1494
Score = 46.6 bits (109), Expect = 1e-04
Identities = 88/356 (24%), Positives = 150/356 (42%), Gaps = 49/356 (13%)
Query: 290 GAKFEAKVQENTQRVGQLRQDVEDRLH---AQHFTLHRSISELQADVDTKLKRLHKAQEA 346
G + A+ E QR ++V L+ ++ L + +S +A + + L + A
Sbjct: 1288 GERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRA 1347
Query: 347 PGTNGSLVLA--TPGAGARP---EPDSLQARLG-QLQRNLSELHMTTARREEELQYTL-- 398
GS V A AG R E + + R G +LQ ++L R+EEE
Sbjct: 1348 KLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG 1407
Query: 399 EDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIME 458
E+ R R + + + +E ET D++ + R++++ EL M+
Sbjct: 1408 EEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ---------ELDDATMDL----- 1453
Query: 459 ENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREG-QRDA-----T 512
E +RQL+ TL+ Q L+ K + + EG +R+A T
Sbjct: 1454 ----EQQRQLVS---TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1506
Query: 513 RALEETQVSLDERRQLDGS---SLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQ 569
RALEE Q + +E + + + L+AL ++ D V +V + A A + LR+QV
Sbjct: 1507 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1566
Query: 570 ALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQ 625
L+DE+ A + A V+ L + L+ R EA GEE ++++Q
Sbjct: 1567 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQG--RDEA------GEERRRQLAKQ 1614
Score = 39.7 bits (91), Expect = 0.013
Identities = 93/471 (19%), Positives = 185/471 (39%), Gaps = 77/471 (16%)
Query: 250 QSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQ 309
+S+H L +A R R ++ ++D A D AK +V + Q +
Sbjct: 1542 KSVHELERACRVAEQAANDLRAQVTELEDELTAAED-----AKLRLEVTVQALKT-QHER 1595
Query: 310 DVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSL 369
D++ R A + +L+ D +++R + ++ T AR + L
Sbjct: 1596 DLQGRDEAGEERRRQLAKQLR---DAEVERDEERKQR----------TLAVAARKK---L 1639
Query: 370 QARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKV 429
+ L +L+ ++ + + +EE L M+A + E++E + +E F Q +
Sbjct: 1640 EGELEELKAQMA----SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES 1695
Query: 430 ERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYV 489
E++++ L+ L+E +++++E+ ++ NL+
Sbjct: 1696 EKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKA------------- 1742
Query: 490 KDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERR---QLDGSSLQALQNAVDAVSLA 546
I E +R L + + L+E + +L + L V++++
Sbjct: 1743 -------------AILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTE 1789
Query: 547 VDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE--VRQLHSAFAALLEDAL 604
+ A ++ +A + +L Q+Q L +G + A A ARH+ + L S A E+ L
Sbjct: 1790 LSAERSFSAKAESGRQQLERQIQELRGRLGE-EDAGARARHKMTIAALESKLAQ-AEEQL 1847
Query: 605 RHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTA 664
E L G+ L +E+ + L E+ R L++ L +L +
Sbjct: 1848 EQETRERILSGK--LVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQ--- 1902
Query: 665 LEQASEPPRPAEHLEPSHDAGRE------EAATTALAGLARELQSLSNDVK 709
LE+A E A+ AGR E T + + RE+ +L N ++
Sbjct: 1903 LEEAEEEASRAQ-------AGRRRLQRELEDVTESAESMNREVTTLRNRLR 1946
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 85.5 bits (210), Expect = 2e-16
Identities = 161/677 (23%), Positives = 272/677 (40%), Gaps = 97/677 (14%)
Query: 164 AAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDR 223
A + +V+ Q+Q +G+LQ V ++ + L + L EA +T R
Sbjct: 916 AQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA-EAEETRGRLAAR 974
Query: 224 SLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVAR 283
E L+ R L Q I+ L +EA A ++Q + +
Sbjct: 975 KQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQ---LEK 1031
Query: 284 ADFQELGAKFEAKV---QENTQRVGQLRQDVEDRLH------AQHFTLHRSISELQ---- 330
+ KFE + ++ ++ + R+ +EDRL A+ +S+++L+
Sbjct: 1032 VTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYE 1091
Query: 331 ---ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTT 387
AD++ +L++ K ++ L E LQ ++ + Q+ EL
Sbjct: 1092 ATIADMEDRLRKEEKGRQE--------LEKLKRRLDGESSELQEQMVEQQQRAEELRAQL 1143
Query: 388 ARREEELQYTL---ED---MRATLTRHVDEIKELYSESDETFDQ----ISKVERQVEELQ 437
R+EEELQ L ED RA L + + E + +E+ E + +K E+Q +L
Sbjct: 1144 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1203
Query: 438 VNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKL 497
ALR ++ + +E + + E+++ EL TL+ H ++ ++ + Q L
Sbjct: 1204 EELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQAL 1263
Query: 498 YLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERA 557
+L E R A E+T+++L+ + L +LQ A + EGE+
Sbjct: 1264 G-ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTA-----------RQEGEQR 1311
Query: 558 RAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEE 617
R RL Q+Q + G + A AEA ++++ + E
Sbjct: 1312 R---RRLELQLQEVQGRAGDGERARAEAAEKLQRAQAEL-------------------EN 1349
Query: 618 VLEEMSEQTPGPLPLSYE--QIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPA 675
V ++E + LS E L DA LQE+ L +RV A+E +E
Sbjct: 1350 VSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME--AEAAGLR 1407
Query: 676 EHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHN 735
E LE EEAA AG RELQ+ + R E EAGA A A
Sbjct: 1408 EQLE-------EEAAARERAG--RELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAARE 1458
Query: 736 ALFATQRSLEQHQRLFHSLFGNFQGLMEA-NVSLDLGKLQTMLSRKGKKQQK-------- 786
A TQR E+ + + G + E + ++DL + + ++S KKQ+K
Sbjct: 1459 AEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEE 1518
Query: 787 ---DLEAPRKRDKKEAE 800
L A +R++ EAE
Sbjct: 1519 KAAVLRAVEERERAEAE 1535
Score = 46.6 bits (109), Expect = 1e-04
Identities = 88/356 (24%), Positives = 150/356 (42%), Gaps = 49/356 (13%)
Query: 290 GAKFEAKVQENTQRVGQLRQDVEDRLH---AQHFTLHRSISELQADVDTKLKRLHKAQEA 346
G + A+ E QR ++V L+ ++ L + +S +A + + L + A
Sbjct: 1329 GERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRA 1388
Query: 347 PGTNGSLVLA--TPGAGARP---EPDSLQARLG-QLQRNLSELHMTTARREEELQYTL-- 398
GS V A AG R E + + R G +LQ ++L R+EEE
Sbjct: 1389 KLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG 1448
Query: 399 EDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIME 458
E+ R R + + + +E ET D++ + R++++ EL M+
Sbjct: 1449 EEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQ---------ELDDATMDL----- 1494
Query: 459 ENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREG-QRDA-----T 512
E +RQL+ TL+ Q L+ K + + EG +R+A T
Sbjct: 1495 ----EQQRQLVS---TLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1547
Query: 513 RALEETQVSLDERRQLDGS---SLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQ 569
RALEE Q + +E + + + L+AL ++ D V +V + A A + LR+QV
Sbjct: 1548 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1607
Query: 570 ALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQ 625
L+DE+ A + A V+ L + L+ R EA GEE ++++Q
Sbjct: 1608 ELEDELTAAEDAKLRLEVTVQALKTQHERDLQG--RDEA------GEERRRQLAKQ 1655
Score = 39.7 bits (91), Expect = 0.013
Identities = 93/471 (19%), Positives = 185/471 (39%), Gaps = 77/471 (16%)
Query: 250 QSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQ 309
+S+H L +A R R ++ ++D A D AK +V + Q +
Sbjct: 1583 KSVHELERACRVAEQAANDLRAQVTELEDELTAAED-----AKLRLEVTVQALKT-QHER 1636
Query: 310 DVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSL 369
D++ R A + +L+ D +++R + ++ T AR + L
Sbjct: 1637 DLQGRDEAGEERRRQLAKQLR---DAEVERDEERKQR----------TLAVAARKK---L 1680
Query: 370 QARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKV 429
+ L +L+ ++ + + +EE L M+A + E++E + +E F Q +
Sbjct: 1681 EGELEELKAQMA----SAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRES 1736
Query: 430 ERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYV 489
E++++ L+ L+E +++++E+ ++ NL+
Sbjct: 1737 EKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKA------------- 1783
Query: 490 KDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERR---QLDGSSLQALQNAVDAVSLA 546
I E +R L + + L+E + +L + L V++++
Sbjct: 1784 -------------AILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTE 1830
Query: 547 VDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE--VRQLHSAFAALLEDAL 604
+ A ++ +A + +L Q+Q L +G + A A ARH+ + L S A E+ L
Sbjct: 1831 LSAERSFSAKAESGRQQLERQIQELRGRLGE-EDAGARARHKMTIAALESKLAQ-AEEQL 1888
Query: 605 RHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTA 664
E L G+ L +E+ + L E+ R L++ L +L +
Sbjct: 1889 EQETRERILSGK--LVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQ--- 1943
Query: 665 LEQASEPPRPAEHLEPSHDAGRE------EAATTALAGLARELQSLSNDVK 709
LE+A E A+ AGR E T + + RE+ +L N ++
Sbjct: 1944 LEEAEEEASRAQ-------AGRRRLQRELEDVTESAESMNREVTTLRNRLR 1987
>gi|45269141 multimerin 1 [Homo sapiens]
Length = 1228
Score = 85.5 bits (210), Expect = 2e-16
Identities = 122/519 (23%), Positives = 207/519 (39%), Gaps = 81/519 (15%)
Query: 9 LGGPLGWGLLGAWAQASS-TSLSDLQSSRTPGVWKAEAEDTGKDPVGRNWCPYPMSKLVT 67
+GG G G +G A + S D SS+ K+ E T G+NWC Y ++L
Sbjct: 165 IGGVGGTGGVGNRAPRETYLSRGDSSSSQRTDYQKSNFETTR----GKNWCAYVHTRLSP 220
Query: 68 LLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWRCCPGYTG 127
+ L ++ + PC C + + PVY+++ K++TSL WRCCPGY+G
Sbjct: 221 TVILDNQVTYVPGGKGPCGWTGGSCPQRS---QKISNPVYRMQHKIVTSLDWRCCPGYSG 277
Query: 128 PNCEHHDSMAIPEPADPGDSHQEPQDGPVSFKPGHLAAVINEVEVQQEQQ----EHLLGD 183
P C+ QE Q + + AV V QQ+QQ ++
Sbjct: 278 PKCQLR--------------AQEQQSLIHTNQAESHTAVGRGVAEQQQQQGCGDPEVMQK 323
Query: 184 LQNDVHRVADSLPGLWKALPGNLTAAVMEANQT-----GHEFPDRSLE-QVLLPHVDT-- 235
+ + V+ A L L K + N++ V + T G D+S E Q LL + +
Sbjct: 324 MTDQVNYQAMKLTLLQKKI-DNISLTVNDVRNTYSSLEGKVSEDKSREFQSLLKGLKSKS 382
Query: 236 -------FLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQE 288
++ F +++ L + + +LS D+E+ RQ I +V +S V+ A Q+
Sbjct: 383 INVLIRDIVREQFKIFQNDMQETVAQLFKTVSSLSEDLESTRQIIQKVNESVVSIAAQQK 442
Query: 289 LGAKFEAKVQENTQR---VGQLRQDVEDRLHAQHFTLHRSISEL---QADVDTKLKRLHK 342
VQEN + +LR + + T + I EL Q ++ L++ H
Sbjct: 443 F-----VLVQENRPTLTDIVELRNHIVNVRQEMTLTCEKPIKELEVKQTHLEGALEQEHS 497
Query: 343 AQ--EAPGTNGSL---------VLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARRE 391
N +L +L+T + + ++ + +S LH ++
Sbjct: 498 RSILYYESLNKTLSKLKEVHEQLLSTEQVSDQKNAPAAESVSNNVTEYMSTLHENIKKQS 557
Query: 392 EELQYTLEDMRATLTRHVDEIK--------ELYSES--DETFDQISKVERQVE-ELQVNH 440
+ ED+ H+ E K E+ ES E D +SK + +L+
Sbjct: 558 LMMLQMFEDL------HIQESKINNLTVSLEMEKESLRGECEDMLSKCRNDFKFQLKDTE 611
Query: 441 TALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQ 479
L L L E M+ +++ QL +L ++ LQ
Sbjct: 612 ENLHVLNQTLAEVLFPMDNKMDKMSEQLNDLTYDMEILQ 650
Score = 67.0 bits (162), Expect = 8e-11
Identities = 42/128 (32%), Positives = 62/128 (48%), Gaps = 4/128 (3%)
Query: 826 VAFYASFSEGTAALQTVKFNTTYINIGSSYFPEHGYFRAPERGVYLFAVSVEFGPGPGTG 885
VAF+AS + G + FN +N G+SY P G FR P GVY+F ++E +G
Sbjct: 1101 VAFFASHTYGMTIPGPILFNNLDVNYGASYTPRTGKFRIPYLGVYVFKYTIESFSAHISG 1160
Query: 886 QLVFGGHHRTPVCTTGQGS----GSTATVFAMAELQKGERVWFELTQGSITKRSLSGTAF 941
LV G + + S T A+ EL G+ VW L +G+I + T F
Sbjct: 1161 FLVVDGIDKLAFESENINSEIHCDRVLTGDALLELNYGQEVWLRLAKGTIPAKFPPVTTF 1220
Query: 942 GGFLMFKT 949
G+L+++T
Sbjct: 1221 SGYLLYRT 1228
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 74.3 bits (181), Expect = 5e-13
Identities = 125/511 (24%), Positives = 208/511 (40%), Gaps = 69/511 (13%)
Query: 309 QDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDS 368
Q D L Q L+R ++E++A+ D+ R + Q+A A + S
Sbjct: 1522 QRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAV------------AESEEARRS 1569
Query: 369 LQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISK 428
+ RL +Q L+ + R E E + TL+ + ATL R + + SE + ++ISK
Sbjct: 1570 VDGRLSGVQAELALQEESVRRSERERRATLDQV-ATLERSLQATE---SELRASQEKISK 1625
Query: 429 VERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTL-------QHLQGG 481
++ +L+ + L+E+ +++ +E + +E +L L L Q LQ
Sbjct: 1626 MKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDR 1685
Query: 482 HADLIKYVKDCNCQKLYLDLDV----------------IREGQRDATRALEETQVSLDER 525
L + V D + L L V +R+ R T AL ++ SL+
Sbjct: 1686 VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNST 1745
Query: 526 RQLD---GSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAA 582
R + +L A ++ + +DA + AR +S L QVQ L EV L+
Sbjct: 1746 RDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQR 1805
Query: 583 AEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEE---MSEQTPGPLPLSYEQIRV 639
EA +++QL R E AAL + L++ + ++ G L + Q+
Sbjct: 1806 VEAEGQLQQLREVLRQ------RQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEA 1859
Query: 640 ALQDA-ASGLQEQALGWDELAARVTALEQASEPPRPAEH-LEPSHDAGREEAATTA---- 693
++ S L+ L D +A R T + E R E + S + GR + T
Sbjct: 1860 EKREVERSALR---LEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELE 1916
Query: 694 LAGLARELQSLSNDVKNVGRC-----CEAEAGAGAASLNASLHGLHNALFATQRSLEQHQ 748
LA R++Q L V + + E +A L + L +A T+R+LE +
Sbjct: 1917 LAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARE 1976
Query: 749 RLFHSLFGNFQGLMEANVSLDLGKLQTMLSR 779
R +GL E VS G+LQ L R
Sbjct: 1977 RAHRQ---RVRGL-EEQVSTLKGQLQQELRR 2003
Score = 65.9 bits (159), Expect = 2e-10
Identities = 106/452 (23%), Positives = 176/452 (38%), Gaps = 56/452 (12%)
Query: 367 DSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKE----------LY 416
++ Q LG L++ LS+ EE+LQ + + H D +E L
Sbjct: 543 EASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLS 602
Query: 417 SESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEE-------VERQLL 469
E + ++Q EEL+ L+ + L + +EE +E+ V R+L
Sbjct: 603 REKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELE 662
Query: 470 ELNLTLQHLQGGHADLIKYVKDCN--CQKLYLDLDVIREGQRDATRALEETQVSLDE--- 524
+ L+ L+G + L K + + + L D+++ + + AL + + E
Sbjct: 663 RSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELEL 722
Query: 525 ---RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAA 581
+ + + +SLQ + + A++ ++ K + L V L++E AL+
Sbjct: 723 SMTKLRAEEASLQDSLSKLSALNESLAQDKLD----------LNRLVAQLEEEKSALQGR 772
Query: 582 AAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVAL 641
+A E L E L E L G + E +++ + EQ L
Sbjct: 773 QRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE-------ALEQQLPTL 825
Query: 642 QDAASGLQEQALGWD-ELAARVTALEQA-SEPPRPAEHLEPSHDAGREEAATTALAGLAR 699
+ S LQEQ +L+ R LEQA E R E LE + A +EA AGLA
Sbjct: 826 RHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERA--AREKEALAKEHAGLAV 883
Query: 700 ELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQ 759
+L + + GR E A L L +LF QR L Q + L Q
Sbjct: 884 QLVAAERE----GRTLSEE----ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQ 935
Query: 760 GLMEANVSL--DLGKLQTMLSRKGKKQQKDLE 789
L+ A +L +L L+ + +K D E
Sbjct: 936 ALLLAKETLTGELAGLRQQIIATQEKASLDKE 967
Score = 58.9 bits (141), Expect = 2e-08
Identities = 95/462 (20%), Positives = 188/462 (40%), Gaps = 43/462 (9%)
Query: 269 NRQAISRVQDSAVARADFQELGA---KFEAKVQENTQRVGQLRQDVED------RLHAQH 319
+R+ + VA+ +EL K +A +E ++ +L ++ ED R+ +
Sbjct: 602 SREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRREL 661
Query: 320 FTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRN 379
HR + +L+ K L + +EA A + D LQA ++
Sbjct: 662 ERSHRQLEQLEGKRSVLAKELVEVREALSR------------ATLQRDMLQAEKAEVAEA 709
Query: 380 LSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVN 439
L++ EL+ ++ +RA D + +L + ++ + R V +L+
Sbjct: 710 LTKAEAGRV----ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEE 765
Query: 440 HTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGG--HADLIKYVKDCNCQKL 497
+AL+ + +++ + E +E +E LE + Q L+G A+ + + L
Sbjct: 766 KSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTL 825
Query: 498 YLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAV--------DAVSLAVD- 548
+ ++E +R L + L++ R+ ++AL+ A + LAV
Sbjct: 826 RHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQL 885
Query: 549 -AHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHE 607
A + EG +RLR + +AL+ + ++ A+ QL + ALL L E
Sbjct: 886 VAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALL---LAKE 942
Query: 608 AVLAALFG-EEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALE 666
+ L G + + E+ L +++ A ++A + L+EQ +E R+ +
Sbjct: 943 TLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREK 1002
Query: 667 QASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDV 708
+A+ AE + RE+ LA L E + LS ++
Sbjct: 1003 EAAWRELEAERAQLQSQLQREQ--EELLARLEAEKEELSEEI 1042
Score = 51.6 bits (122), Expect = 3e-06
Identities = 113/569 (19%), Positives = 215/569 (37%), Gaps = 83/569 (14%)
Query: 251 SLHSLTQAIRNLSLDVE----ANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQ 306
++++LT +R+L E A+ Q + R+Q+ A ++LG + ++ ++E + Q
Sbjct: 1109 TVNALTSELRDLRAQREEAAAAHAQEVRRLQEQA------RDLGKQRDSCLREAEELRTQ 1162
Query: 307 LR--QDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARP 364
LR +D D L + R + E Q + + + + + + G A R
Sbjct: 1163 LRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEG-----AKEREALRR 1217
Query: 365 EPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESD---- 420
+ L++ + + + L + +E++L LE+ R + + E++ E +
Sbjct: 1218 SNEELRSAVKKAESERISLKLANEDKEQKLAL-LEEARTAVGKEAGELRTGLQEVERSRL 1276
Query: 421 ETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQG 480
E ++ ++ RQ++ L +T L L + + E ++E R+ L L Q L
Sbjct: 1277 EARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLR---QRLLK 1333
Query: 481 GHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLD--ERRQLD------GSS 532
G A L +V+R+ + A R L+E + ERR L G+
Sbjct: 1334 GEASL----------------EVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTE 1377
Query: 533 LQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQL 592
Q L +A + L ++A +AE S + Q L+ E+ ++ A ++ L
Sbjct: 1378 KQQLDHA-RGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGL 1436
Query: 593 HSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVA-LQDAASGLQEQ 651
SA LR L +P P P+ R A + + GL
Sbjct: 1437 RSA--------LRRGLGLGRA-----------PSPAPRPVPGSPARDAPAEGSGEGLNSP 1477
Query: 652 ALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNV 711
+ S+PP P P+ EA AL +EL+S + ++
Sbjct: 1478 S---------TLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRE-RDE 1527
Query: 712 GRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLG 771
R + A + A + Q+++ + + S+ G G+ L L
Sbjct: 1528 LRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGV---QAELALQ 1584
Query: 772 KLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ S + ++ D A +R + E
Sbjct: 1585 EESVRRSERERRATLDQVATLERSLQATE 1613
Score = 36.2 bits (82), Expect = 0.15
Identities = 125/585 (21%), Positives = 218/585 (37%), Gaps = 82/585 (14%)
Query: 270 RQAISRVQD---SAVARADFQELGAKFEAKVQENT------------QRVGQLRQDVEDR 314
R+A+ R + SAV +A+ + + K + +E + G+LR +++
Sbjct: 1212 REALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQE- 1270
Query: 315 LHAQHFTLHRSISELQADV---DTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQA 371
+ R + EL+ + D++ RL +E G L L G R E +S +
Sbjct: 1271 VERSRLEARRELQELRRQMKMLDSENTRL--GRELAELQGRLAL-----GERAEKESRRE 1323
Query: 372 RLGQLQRNLS-ELHMTTARRE-----EELQYTLEDMRATLTRHVDEIKELYSESDETFDQ 425
LG QR L E + R+E +LQ + R R + ++E + D
Sbjct: 1324 TLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDH 1383
Query: 426 ISKVERQVEELQVNHTALRELRVILME---KSLIMEENKEEVERQLLELNLTLQHLQGGH 482
+E ++E + L LR+ E + L E + EV+R+ E L GG
Sbjct: 1384 ARGLELKLEAARAEAAELG-LRLSAAEGRAQGLEAELARVEVQRRAAEAQL------GGL 1436
Query: 483 ADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLD---GSSLQALQNA 539
++ V RDA E + L+ L+ GS + A
Sbjct: 1437 RSALRRGLGLGRAPSPAPRPVPGSPARDAPA--EGSGEGLNSPSTLECSPGSQPPSPGPA 1494
Query: 540 VDAVSLAVDAHKAEG---------ERARAATSRLRSQVQALDDEVGALKAAAAEARHEVR 590
S +D G A+ LR+Q AL+ ++ ++A A R
Sbjct: 1495 TSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRAR 1554
Query: 591 QLHSAFAALLEDALRHEAVLAALFGEEVLEEMS-EQTPGPLPLSYEQIRV---ALQDAAS 646
QL A A E + L+ + E L+E S ++ + +Q+ +LQ S
Sbjct: 1555 QLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATES 1614
Query: 647 GLQEQALGWDELAARVTALE----------QASEPPRPAEHLEPSHDAGREEAATTALAG 696
L+ ++ A T LE ASE L+ G + + L+
Sbjct: 1615 ELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSD 1674
Query: 697 LARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFG 756
+ Q+L + V ++ R A++ A +L ++ L+ AL + E L + G
Sbjct: 1675 REAQAQALQDRVDSLQRQV-ADSEVKAGTLQLTVERLNGALAKVE---ESEGALRDKVRG 1730
Query: 757 NFQGLMEANVSLD--------LGKLQTMLSRKGKKQQKDLEAPRK 793
+ L +++ SL+ L K T + Q+ L+A R+
Sbjct: 1731 LTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQ 1775
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 72.8 bits (177), Expect = 1e-12
Identities = 145/657 (22%), Positives = 267/657 (40%), Gaps = 82/657 (12%)
Query: 163 LAAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPD 222
+A + E + QE + LGDLQ + RV+ LT A + Q + +
Sbjct: 1038 VARLTKEKKALQEAHQQALGDLQAEEDRVSA------------LTKAKLRLEQQVEDL-E 1084
Query: 223 RSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVA 282
SLEQ +DT R L +++ + + D + + + + +DS ++
Sbjct: 1085 CSLEQEKKLRMDT------ERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKK-KDSELS 1137
Query: 283 RA-----DFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKL 337
+ D Q LGA+ + K++E R +L +++E A+ + + +A+ +L
Sbjct: 1138 QLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAAR-----ARVEKQRAEAAREL 1192
Query: 338 KRL-HKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQY 396
+ L + +EA G + AG R +A LG+L+R L E + L+
Sbjct: 1193 EELSERLEEAGGAS---------AGQREGCRKREAELGRLRRELEEAALRHEATVAALRR 1243
Query: 397 TLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLI 456
+ A L VD ++ + + ++ + S++ +V++L N L + +
Sbjct: 1244 KQAEGAAELGEQVDSLQRVRQKLEK---EKSELRMEVDDLAANVETLTRAKASAEKLCRT 1300
Query: 457 MEENK-------EEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQR 509
E+ EE++RQL + + LQ +L + +++ C + + G+
Sbjct: 1301 YEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECL-----ISQLSRGKA 1355
Query: 510 DATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQ 569
A ++LEE + L+E + + A+Q L + H+ E E A+A RL S+
Sbjct: 1356 LAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAE-AQAELQRLLSKAN 1414
Query: 570 A-LDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPG 628
A + +A A + E+ + A L++A E V AA LE+ +
Sbjct: 1415 AEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEA--EEGVEAANAKCSSLEKAKLR--- 1469
Query: 629 PLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGRE- 687
L E + + L+ A S L + LE+A E R E + RE
Sbjct: 1470 -LQTESEDVTLELERATSAAA-------ALDKKQRHLERALEERRRQE-----EEMQREL 1516
Query: 688 EAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQH 747
EAA GL EL L + + E +L + L + + + +S+++
Sbjct: 1517 EAAQRESRGLGTELFRLRHGHEEALEALETLKREN-KNLQEEISDLTDQVSLSGKSIQEL 1575
Query: 748 QRLFHSLFGNFQ----GLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
++ +L G L EA +L+L + +T+ + Q K E RK +K+ E
Sbjct: 1576 EKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVK-AEVDRKLAEKDEE 1631
Score = 61.6 bits (148), Expect = 3e-09
Identities = 120/535 (22%), Positives = 206/535 (38%), Gaps = 87/535 (16%)
Query: 254 SLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVG----QLRQ 309
+L A++ L D + R+ + ++ A A+A+ Q L +K A+V + + Q +
Sbjct: 1377 ALAHAVQALRHDCDLLRE---QHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTE 1433
Query: 310 DVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQ-----EAPGTNGSLVLATPGAGARP 364
++E+ L + ++A + K L KA+ E+ L AT A A
Sbjct: 1434 ELEEAKKKLALRLQEAEEGVEA-ANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALD 1492
Query: 365 EPDS-LQARLGQLQRNLSELH--MTTARREEE--------LQYTLEDMRATLTRHVDEIK 413
+ L+ L + +R E+ + A+RE L++ E+ L E K
Sbjct: 1493 KKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENK 1552
Query: 414 ELYSESDETFDQISKVERQVEELQVNHTALR----ELRVILMEK--SLIMEENKE----- 462
L E + DQ+S + ++EL+ AL E++ L E +L +EE K
Sbjct: 1553 NLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQL 1612
Query: 463 -------EVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRAL 515
EV+R+L E + +L+ H + + L LD + +A R
Sbjct: 1613 ELSQVKAEVDRKLAEKDEECANLRRNHQRAV--------ESLQASLDAETRARNEALRLK 1664
Query: 516 EETQVSLDERR-QLDGSSLQAL--QNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALD 572
++ + L++ QL ++ QA Q A + + +A + + + L Q QAL+
Sbjct: 1665 KKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALE 1724
Query: 573 DEVGALKAAAAEARHEVRQ---------------------LHSAFAALLEDALRHEAVLA 611
L A E R + Q LHS LL + EA LA
Sbjct: 1725 RRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLA 1784
Query: 612 ALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEP 671
L GE +EE +++ R A + A + + A+ +EL
Sbjct: 1785 QLSGE--VEEAAQER-----------REAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1831
Query: 672 PRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASL 726
+ E A EEA AL G +++Q L V+ + +AE A +L
Sbjct: 1832 KKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEAL 1886
Score = 60.8 bits (146), Expect = 6e-09
Identities = 105/419 (25%), Positives = 178/419 (42%), Gaps = 71/419 (16%)
Query: 280 AVARADFQELGAKFEAKVQENTQRVGQLRQ------DVEDRLHAQHFTLHRSISELQADV 333
A A A QEL + QE QL+ D E+R H L +S +L+ V
Sbjct: 913 AAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHL----LIKSKVQLEGKV 968
Query: 334 DTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEE 393
+RL +E A L+ +L++++ +L +T A+ E+E
Sbjct: 969 KELSERLEDEEEV------------NADLAARRRKLEDECTELKKDIDDLKLTLAKAEKE 1016
Query: 394 LQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHT-ALRELRVILME 452
Q T +++K L E + ++++ ++ + LQ H AL +L+ +
Sbjct: 1017 KQAT-----------ENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAE-ED 1064
Query: 453 KSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDAT 512
+ + + K +E+Q+ +L +L+ + D + + KL DL + +E DA
Sbjct: 1065 RVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKR-----KLEGDLKLTQESVADAA 1119
Query: 513 R---ALEE---------TQVSLD-ERRQLDGSSLQA----LQNAVDAVSLAVDAHKAEG- 554
+ LEE +Q+SL E QL G+ +Q LQ + + ++A +A
Sbjct: 1120 QDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAARA 1179
Query: 555 --ERARAATSRLRSQVQALDDEVGALKAAAAEA-RHEVRQLHSAFAALLEDALRHEAVLA 611
E+ RA +R ++ +E G A E R +L L E ALRHEA +A
Sbjct: 1180 RVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATVA 1239
Query: 612 ALFGE--EVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQA 668
AL + E E+ EQ S +++R L+ S L+ + D+LAA V L +A
Sbjct: 1240 ALRRKQAEGAAELGEQVD-----SLQRVRQKLEKEKSELRMEV---DDLAANVETLTRA 1290
>gi|60498978 elastin microfibril interfacer 2 [Homo sapiens]
Length = 1053
Score = 68.9 bits (167), Expect = 2e-11
Identities = 92/416 (22%), Positives = 171/416 (41%), Gaps = 51/416 (12%)
Query: 55 RNWCPYPMSKLVTLLALCKTEKFLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVL 114
+NWC Y ++K V+ L +E F I +Q C C V YR+ +P Y + K +
Sbjct: 45 KNWCAYIVNKNVSCSVLEGSESF-IQAQYNCAWNQMPCPSALV-YRVNFRPRYVTRYKTV 102
Query: 115 TSLAWRCCPGYTGPNCEHHDSMAI----PEPADPGDSHQEPQDGPVS--------FKPGH 162
T L WRCCPG+ G +C+ + P PA P +S ++ D S P
Sbjct: 103 TQLEWRCCPGFRGGDCQEGPKDPVKTLRPTPARPRNSLKKATDNEPSQFSEPRKTLSPTG 162
Query: 163 LAAV---INEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPG---NLTAAVM-EANQ 215
A ++ E QE QE + L+ V R+ ++ L +L G NL A +A++
Sbjct: 163 TAQPSWGVDPKEGPQELQEKKIQVLEEKVLRLTRTVLDLQSSLAGVSENLKHATQDDASR 222
Query: 216 T-------GHEFPDRSL----EQVLLPHVDTFLQVHFSPI---WRSFNQSLHSLTQAIRN 261
T H PD ++ E P V + I +L + + +
Sbjct: 223 TRAPGLSSQHPKPDTTVSGDTETGQSPGVFNTKESGMKDIKSELAEVKDTLKNKSDKLEE 282
Query: 262 LSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFT 321
L V+ + ++Q++A ++A V ++ LR+++ +
Sbjct: 283 LDGKVKGYEGQLRQLQEAAQGPTVTMTTNELYQAYVD---SKIDALREELME-------G 332
Query: 322 LHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPG---AGARPEPDSLQARLGQLQR 378
+ R +++L+ + KL L + + G++ V+ G R E ++L+AR LQ
Sbjct: 333 MDRKLADLKNSCEYKLTGLQQQCDDYGSSYLGVIELIGEKETSLRKEINNLRAR---LQE 389
Query: 379 NLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVE 434
++ + + + ++ ++ + + R + + L D FD++ E V+
Sbjct: 390 PSAQANCCDSEKNGDIGQQIKTLDQKIERVAEATRMLNGRLDNEFDRLIVPEPDVD 445
Score = 36.6 bits (83), Expect = 0.11
Identities = 28/85 (32%), Positives = 34/85 (40%), Gaps = 16/85 (18%)
Query: 808 TGPVPGALGAA----------LWEAGSPVAFYASFSEGTAALQ------TVKFNTTYINI 851
+G VPGA G A + G+PV SFS G V FN +N
Sbjct: 874 SGTVPGAEGFAGAPGYPKSPPVASPGAPVPSLVSFSAGLTQKPFPSDGGVVLFNKVLVND 933
Query: 852 GSSYFPEHGYFRAPERGVYLFAVSV 876
G Y P G F AP G YL ++
Sbjct: 934 GDVYNPSTGVFTAPYDGRYLITATL 958
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 63.5 bits (153), Expect = 9e-10
Identities = 133/633 (21%), Positives = 248/633 (39%), Gaps = 104/633 (16%)
Query: 168 NEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQ 227
N ++ QQE++E +L+ V + L K + +L SLE+
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTI-------------ESLEE 1392
Query: 228 V---LLPHVDTFLQ--VHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQ----- 277
LL + Q + + ++ + L Q + +L++D++ RQ S ++
Sbjct: 1393 AKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKK 1452
Query: 278 -DSAVAR-----ADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHA------QHFTLHRS 325
D +A A + E + EA+ +E + L + +E+ L A Q+ L
Sbjct: 1453 FDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD 1512
Query: 326 ISELQADVDTKLKRLHKAQEAPGTNGSLV--------------LATPGAGARPEPDSLQA 371
+ +L + D K +H+ +++ V AT A R E + +QA
Sbjct: 1513 MEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVN-MQA 1571
Query: 372 RLGQLQRNLS-------ELHMTTARREEELQYTLEDMR-------ATLTRHVDEIKELYS 417
Q +R+L E ++ EL+ LED R A+ + ++K+L +
Sbjct: 1572 MKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEA 1631
Query: 418 E-------SDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLE 470
+ DE Q+ K++ Q+++ Q R R + +S E+ + +E ++L+
Sbjct: 1632 QIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQ 1691
Query: 471 LNLTL-------QHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLD 523
L L +H + +L + + K L D R LE L+
Sbjct: 1692 LQEELASSERARRHAEQERDELADEITNSASGKSAL---------LDEKRRLEARIAQLE 1742
Query: 524 ERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAA 583
E + + S+++ L + +L VD AE R+A + + Q L+ + LKA
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802
Query: 584 EARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPL------SYEQI 637
E V+ A + LE A + L EE LE+ +++ L ++I
Sbjct: 1803 ELEGAVKSKFKATISALE------AKIGQL--EEQLEQEAKERAAANKLVRRTEKKLKEI 1854
Query: 638 RVALQDAASGLQEQALGWDELAARVTALE-QASEPPRPAEHLEPSHDAGREEA--ATTAL 694
+ ++D + ++ AR+ L+ Q E A S + E AT A
Sbjct: 1855 FMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEAN 1914
Query: 695 AGLARELQSLSNDVKNVGRCCEAEAGAGAASLN 727
GL+RE+ +L N ++ G + + +G L+
Sbjct: 1915 EGLSREVSTLKNRLRRGGPISFSSSRSGRRQLH 1947
Score = 55.1 bits (131), Expect = 3e-07
Identities = 121/562 (21%), Positives = 226/562 (40%), Gaps = 74/562 (13%)
Query: 175 EQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQV----LL 230
E++ L LQ + A++ + + L A E + H+ R E+ +L
Sbjct: 887 EEKNILAEQLQAETELFAEA-----EEMRARLAAKKQELEEILHDLESRVEEEEERNQIL 941
Query: 231 PHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELG 290
+ +Q H + + L A + L L+ I ++++ + D
Sbjct: 942 QNEKKKMQAHIQDL----EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKF 997
Query: 291 AKFEAKVQENTQRVGQLRQDV-EDRLHAQHFTLHRSISELQ-ADVDTKLKRLHKAQEAPG 348
K E K+ E+ R+ + + E+ A++ R+ E+ +D++ +LK+ K ++
Sbjct: 998 IK-EKKLMED--RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE-- 1052
Query: 349 TNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLED------MR 402
L E LQ ++ +LQ + EL + A++EEELQ L +
Sbjct: 1053 ------LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHK 1106
Query: 403 ATLTRHVDEIKELYSESDETFD----QISKVERQVEELQVNHTALRELRVILMEKSLIME 458
+ V E++ +E E F+ +K E+Q +L AL+ ++ + +
Sbjct: 1107 NNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166
Query: 459 ENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEET 518
E + + E+++ EL L+ H I+ ++ QR AT ALEE
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMR-----------------QRHAT-ALEEL 1208
Query: 519 QVSLDERRQLDGSSLQALQN-AVDAVSLAVDAH-----KAEGERARAATSRLRSQVQALD 572
L++ ++ + + Q D LA + KAE E R +L +QVQ L
Sbjct: 1209 SEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKR---KKLDAQVQELH 1265
Query: 573 DEVG---ALKAAAAEARHEVRQLHSAFAALLEDA----LRHEAVLAALFG--EEVLEEMS 623
+V L+ AE +++ + LLE+A ++ A+L ++ E +
Sbjct: 1266 AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325
Query: 624 EQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHD 683
E+T L LS +IR L++ + LQEQ +E + A + + D
Sbjct: 1326 EETRQKLNLS-SRIR-QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 684 AGREEAATTALAGLARELQSLS 705
G E+ A L ++ ++LS
Sbjct: 1384 LGTIESLEEAKKKLLKDAEALS 1405
Score = 52.4 bits (124), Expect = 2e-06
Identities = 115/556 (20%), Positives = 221/556 (39%), Gaps = 79/556 (14%)
Query: 267 EANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHF------ 320
EA ++ I +D+A + Q+ + + ++ ++RQ E++ Q
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Query: 321 ---TLHRSISELQADV-DTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQL 376
L + + LQ+ + DTK K + GT SL A + ++L RL +
Sbjct: 1358 ARKNLEKQVLALQSQLADTK----KKVDDDLGTIESLEEAKKKL--LKDAEALSQRLEEK 1411
Query: 377 QRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQV--- 433
+L T R ++EL +D+ L H ++ + + FDQ+ E+ +
Sbjct: 1412 ALAYDKLEKTKNRLQQEL----DDLTVDLD-HQRQVASNLEKKQKKFDQLLAEEKSISAR 1466
Query: 434 --EELQVNHTALRELRVILMEKSLIMEEN---KEEVERQLLELNLTLQHLQGGHADLIKY 488
EE RE + + +EE KEE ERQ +L ++ L D+ K
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 489 VKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVD 548
V + + + +R + +EE + L+E LQA ++A + + +
Sbjct: 1527 VHE------------LEKSKRALEQQVEEMRTQLEELE----DELQATEDAKLRLEVNMQ 1570
Query: 549 AHKAEGER-ARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRH- 606
A KA+ ER + + + + L +V L+A + R + R L A +E L+
Sbjct: 1571 AMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ-RALAVASKKKMEIDLKDL 1629
Query: 607 EAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALE 666
EA + A + +E+ +Q +++ ++D L+E DE+ A
Sbjct: 1630 EAQIEA--ANKARDEVIKQ--------LRKLQAQMKDYQRELEEARASRDEIFA------ 1673
Query: 667 QASEPPRPAEHLEPSHDAGREEAATT--ALAGLARELQSLSNDVKNVGRCCEAEAGAGAA 724
Q+ E + + LE +EE A++ A +E L++++ N + +G +
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN--------SASGKS 1725
Query: 725 SLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQ 784
+L L + + LE+ Q L F+ +L + L L+ +
Sbjct: 1726 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR-----KTTLQVDTLNAELAAERSAA 1780
Query: 785 QKDLEAPRKRDKKEAE 800
QK A ++ +++ E
Sbjct: 1781 QKSDNARQQLERQNKE 1796
Score = 35.0 bits (79), Expect = 0.33
Identities = 52/270 (19%), Positives = 104/270 (38%), Gaps = 33/270 (12%)
Query: 405 LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV 464
+TR +E++ E + ++ +KVE ++EE++ H L E + IL E+ E E
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 465 ERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDE 524
E L Q L+ +++ + + E Q+ +E
Sbjct: 907 EEMRARLAAKKQELE----------------------EILHDLESRVEEEEERNQILQNE 944
Query: 525 RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDD-------EVGA 577
++++ + +Q L+ +D A + E A A ++ ++ L+D E
Sbjct: 945 KKKMQ-AHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL 1003
Query: 578 LKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQI 637
++ AE ++ + L + + E +++ L EE + Q +
Sbjct: 1004 MEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGE 1063
Query: 638 RVALQDAASGLQEQALGWDELAARVTALEQ 667
LQD + LQ Q DEL ++ E+
Sbjct: 1064 TTDLQDQIAELQAQI---DELKLQLAKKEE 1090
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 63.5 bits (153), Expect = 9e-10
Identities = 132/560 (23%), Positives = 224/560 (40%), Gaps = 90/560 (16%)
Query: 267 EANRQAI-SRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRS 325
E QA+ +R +++ + QE + +VQ+ +QR Q ++ R+ A+
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 326 ISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHM 385
LQA + +L+ A+EA +R L + +
Sbjct: 1532 QRALQALEELRLQ----AEEA------------------------------ERRLRQAEV 1557
Query: 386 TTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRE 445
AR ++Q LE T R + EL S+ ++ +++ER ++E V LRE
Sbjct: 1558 ERAR---QVQVALE----TAQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608
Query: 446 LRVILMEKSLIMEENKEEVERQL----LELNLTLQ-HLQGGHADLIKYVKDCNC--QKLY 498
++ E +EE ER+L L+ N L+ LQ K + QK
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 499 LDLDVIREG--QRDATRALEETQVSLDERRQL-DGSSLQALQNAVDAVSLAVDAHKAEGE 555
+ + R G + A R E + L+++RQL +G++ Q L A + E
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL------------AAEQELI 1716
Query: 556 RARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAA-LF 614
R RA T + Q Q L++E+ L+ AA A + ++L + A + + E +LA+
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM---EVLLASKAR 1773
Query: 615 GEEVLEEMSEQTPGPLPLSYEQIRVALQDAA--SGLQEQALGWDELAARVTALEQASEPP 672
EE SE++ L + R ++AA L E+A +LA A ++A
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1833
Query: 673 RPAEHLEPSHDAGR----EEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
AE L +A R E A L+ L+ D R E +A A +
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893
Query: 729 SLHGLHNA-----------LFATQRSLEQHQRLFHSLFGNFQ--GLMEANVSLDLGKLQT 775
L L A + T R Q + +L +F+ +A + L+LG++++
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 776 ML-SRKGKKQQKDLEAPRKR 794
K+Q +LEA R+R
Sbjct: 1954 NAEDTLRSKEQAELEAARQR 1973
Score = 59.7 bits (143), Expect = 1e-08
Identities = 129/591 (21%), Positives = 216/591 (36%), Gaps = 77/591 (13%)
Query: 265 DVEANRQ---AISRVQDSAVA-----RADFQELGAKFEAKVQENTQRVGQLRQDVEDRLH 316
+VE RQ A+ Q SA A RA F E A+ E +QE V QLR++ E R
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 317 AQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQL 376
Q R+ E + +++ + ++A + A A E +A
Sbjct: 1616 -QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 377 QRNLSELHMTTARR--EEELQYTLEDMRATLTRHV---DEIKELYSESDETFDQISKVER 431
+R +E R E+EL+ + T + + E+ L +E+++ Q +E
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734
Query: 432 QVEELQVNHTAL---------------RELRVILMEKSLIMEENK--EEVERQLLELNL- 473
++ LQ A E+ V+L K+ EE++ E +Q LE
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 474 TLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSL 533
+ L A L ++ Q+ + D R+ + +A R L E ++ E +L +
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEA- 1852
Query: 534 QALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLH 593
+A+ +AE ER R Q + L+++ KA E ++R+
Sbjct: 1853 ----------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 594 SA----FAALLEDALRHEAVLAALFGEEVLE-----EMSEQTPGPLPLSYEQIRVALQDA 644
+ L+ED LR + EE+L E + L L +IR +D
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVE----EEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSL 704
++ L E A + + R AE A EEAA A L E++ L
Sbjct: 1959 LRSKEQAEL---EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERL 2014
Query: 705 SNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFA---------------TQRSLEQHQR 749
V+ R E A L + L A Q++L+Q Q
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 750 LFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ L G + A + ++Q ++Q + EA R + E +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQ 2124
Score = 53.5 bits (127), Expect = 9e-07
Identities = 145/632 (22%), Positives = 233/632 (36%), Gaps = 117/632 (18%)
Query: 257 QAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQL-RQDVEDRL 315
+A+R L L E Q S Q A + + E A+ K +E R +L Q++E +
Sbjct: 1640 EALR-LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 316 HAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLV-LATPGAGARPEPDSLQARLG 374
T + ++ Q + + + Q+ L L A A + L+A L
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 375 QLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSES--------------- 419
+++ + L + AR EEE + T E + L +EL E+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818
Query: 420 ---DETFDQISKVERQV-EELQVNHTALR---ELRVILMEKSLIME-------------- 458
++ Q ++ ER + E+L A R E + L EK E
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1878
Query: 459 -------ENKEEVERQLLEL----NLTLQHLQGGHADLIKYVKDCNCQKLYL-------- 499
++K ++E +L +L + L+ +G D ++ + + L L
Sbjct: 1879 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Query: 500 --------DLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHK 551
+L IR D R+ E+ ++ +RQL + + A + V ++
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL---A 1995
Query: 552 AEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLA 611
AE E AR Q +A +EV LKA EAR + A L+ L EA
Sbjct: 1996 AEEEAAR--------QRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQEAAQK 2045
Query: 612 ALFGEEVLEEMS-EQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELA--ARVTALEQA 668
L EE + +Q L + +Q + L D G E A E A ARV A +A
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVL-DQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 669 SEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
++ R E E + E+A A A A E + + E EA A + A
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAE---------KLRKEAEQEAARRAQAEQA 2155
Query: 729 SLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDL 788
+L A +E+H++ F +A V +L L+ L QK+L
Sbjct: 2156 ALRQKQ----AADAEMEKHKK-----FAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNL 2204
Query: 789 -------------EAPRKRDKKEAEPLVDIRV 807
EA R+R + E E L +RV
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVE-EELFSVRV 2235
Score = 47.4 bits (111), Expect = 6e-05
Identities = 103/542 (19%), Positives = 198/542 (36%), Gaps = 39/542 (7%)
Query: 267 EANRQAISRVQDSAVARADFQELGAKFEAKVQENT-QRVGQLRQDVEDRLHAQHFTLHRS 325
E+ RQ + Q++A R +E F + +E Q+ Q Q V D+L + R+
Sbjct: 2031 ESARQ-LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089
Query: 326 ISELQ-ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELH 384
E + A V + + ++ A A AR + + +L + E
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK------EAE 2143
Query: 385 MTTARREEELQYTLEDMRAT---LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHT 441
ARR + Q L +A + +H ++ + + +++ + Q+EE
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203
Query: 442 ALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHL-------QGGHADLIKYVKDCNC 494
L E L ++ + +VE +L + + ++ L + + LI KD
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263
Query: 495 QKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEG 554
+ L + + +++ +A R Q + R+ + Q A + + A + E
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EA 2322
Query: 555 ERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALF 614
R +A L+ Q + ++ L+ + ++ + F LE + + ++A
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 615 GEEVLE--EMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPP 672
L EMS + ++ R ++ L L E V LE
Sbjct: 2383 ERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE------ 2435
Query: 673 RPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHG 732
+ + HDA E A+A L RE + L + K + E L
Sbjct: 2436 --IQRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 733 LHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPR 792
L + + + SL Q +R + L + V+ K Q L + ++QQ+ +E R
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQ-QLREEQQRQQQQMEQER 2545
Query: 793 KR 794
+R
Sbjct: 2546 QR 2547
Score = 40.4 bits (93), Expect = 0.008
Identities = 69/341 (20%), Positives = 144/341 (42%), Gaps = 32/341 (9%)
Query: 270 RQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISEL 329
++ + VQ++ +A+ + L + E QE +R+ + ++ + +L + R+ L
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRT---L 2368
Query: 330 QADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTAR 389
+A+ +L+ +A+ V A AR E D+ + R Q + +LH T
Sbjct: 2369 EAERQRQLEMSAEAERLK----LRVAEMSRAQARAEEDAQRFRK-QAEEIGEKLHRTELA 2423
Query: 390 REEE--LQYTLEDMRATLTRHVDEIKELYSESDETFDQISK----VERQVEELQV--NHT 441
+E+ L TLE R + ++E +E + +++ + ++ + EE+Q
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 442 ALRELRVI----------LMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKD 491
L+E + + L+++ +E+ K ++E+ + Q L+ + ++
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 492 CNCQKLYLDLDVIREGQRDAT----RALEETQVSLDERRQLDGSSLQALQNAVDAVSLAV 547
Q+L ++ R Q +A R EE Q +RRQ + + Q + + L
Sbjct: 2544 -ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Query: 548 DAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE 588
+ H+A + T+ + + L + AL AAEA E
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 39.3 bits (90), Expect = 0.018
Identities = 111/590 (18%), Positives = 218/590 (36%), Gaps = 76/590 (12%)
Query: 226 EQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARAD 285
E+VL H + + P + L + +++ L EA + ++D
Sbjct: 1102 EEVLRAHEEQLKEAQAVP---ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGA-- 1156
Query: 286 FQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQE 345
QE+G + + + E V + R+ V L L ++ Q +++ ++L +E
Sbjct: 1157 -QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRE 1214
Query: 346 APGTNGSLVLATPGAGARPEPDSLQAR-LGQLQRNLSELHMTTARREEELQYTLEDMRAT 404
+ G+ + AR + +QA L Q +L A EE
Sbjct: 1215 SADPLGAWL-----QDARRRQEQIQAMPLADSQAVREQLRQEQALLEE------------ 1257
Query: 405 LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV 464
+ RH ++++E + + + I E Q+ V + A E V K ++ E V
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQL----VTYKAQLE-PVASPAKKPKVQSGSESV 1312
Query: 465 ERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDE 524
++ ++L L + IK++ + R +EE + ++
Sbjct: 1313 IQEYVDLRTHYSELTTLTSQYIKFISE-------------------TLRRMEEEERLAEQ 1353
Query: 525 RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAE 584
+R + L ++ A++ +AH +A L+ ++Q +EV + AA +
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVD 1410
Query: 585 ARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDA 644
A+ + R + L + + EA + A + E S E+IRV
Sbjct: 1411 AQQQKRSIQEELQQLRQSS---EAEIQAKARQAEAAERSRLR------IEEEIRVVRLQL 1461
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAE------HLEPSHDAGREEAATTALAG-- 696
+ +++ EL A E+A R A+ + ++ R+ A LA
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 697 -----LARELQSLSNDVKNVG-RCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRL 750
ARE Q ++ + + EAE A + + + AL QRS E +
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA-RQVQVALETAQRSAEAELQS 1580
Query: 751 FHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ F +E ++ + + + ++ Q+ EA R R++ E E
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1630
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 63.5 bits (153), Expect = 9e-10
Identities = 132/560 (23%), Positives = 224/560 (40%), Gaps = 90/560 (16%)
Query: 267 EANRQAI-SRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRS 325
E QA+ +R +++ + QE + +VQ+ +QR Q ++ R+ A+
Sbjct: 1476 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1535
Query: 326 ISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHM 385
LQA + +L+ A+EA +R L + +
Sbjct: 1536 QRALQALEELRLQ----AEEA------------------------------ERRLRQAEV 1561
Query: 386 TTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRE 445
AR ++Q LE T R + EL S+ ++ +++ER ++E V LRE
Sbjct: 1562 ERAR---QVQVALE----TAQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1612
Query: 446 LRVILMEKSLIMEENKEEVERQL----LELNLTLQ-HLQGGHADLIKYVKDCNC--QKLY 498
++ E +EE ER+L L+ N L+ LQ K + QK
Sbjct: 1613 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672
Query: 499 LDLDVIREG--QRDATRALEETQVSLDERRQL-DGSSLQALQNAVDAVSLAVDAHKAEGE 555
+ + R G + A R E + L+++RQL +G++ Q L A + E
Sbjct: 1673 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL------------AAEQELI 1720
Query: 556 RARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAA-LF 614
R RA T + Q Q L++E+ L+ AA A + ++L + A + + E +LA+
Sbjct: 1721 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM---EVLLASKAR 1777
Query: 615 GEEVLEEMSEQTPGPLPLSYEQIRVALQDAA--SGLQEQALGWDELAARVTALEQASEPP 672
EE SE++ L + R ++AA L E+A +LA A ++A
Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1837
Query: 673 RPAEHLEPSHDAGR----EEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
AE L +A R E A L+ L+ D R E +A A +
Sbjct: 1838 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1897
Query: 729 SLHGLHNA-----------LFATQRSLEQHQRLFHSLFGNFQ--GLMEANVSLDLGKLQT 775
L L A + T R Q + +L +F+ +A + L+LG++++
Sbjct: 1898 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1957
Query: 776 ML-SRKGKKQQKDLEAPRKR 794
K+Q +LEA R+R
Sbjct: 1958 NAEDTLRSKEQAELEAARQR 1977
Score = 59.7 bits (143), Expect = 1e-08
Identities = 129/591 (21%), Positives = 216/591 (36%), Gaps = 77/591 (13%)
Query: 265 DVEANRQ---AISRVQDSAVA-----RADFQELGAKFEAKVQENTQRVGQLRQDVEDRLH 316
+VE RQ A+ Q SA A RA F E A+ E +QE V QLR++ E R
Sbjct: 1560 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1619
Query: 317 AQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQL 376
Q R+ E + +++ + ++A + A A E +A
Sbjct: 1620 -QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1678
Query: 377 QRNLSELHMTTARR--EEELQYTLEDMRATLTRHV---DEIKELYSESDETFDQISKVER 431
+R +E R E+EL+ + T + + E+ L +E+++ Q +E
Sbjct: 1679 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1738
Query: 432 QVEELQVNHTAL---------------RELRVILMEKSLIMEENK--EEVERQLLELNL- 473
++ LQ A E+ V+L K+ EE++ E +Q LE
Sbjct: 1739 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1798
Query: 474 TLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSL 533
+ L A L ++ Q+ + D R+ + +A R L E ++ E +L +
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEA- 1856
Query: 534 QALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLH 593
+A+ +AE ER R Q + L+++ KA E ++R+
Sbjct: 1857 ----------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1906
Query: 594 SA----FAALLEDALRHEAVLAALFGEEVLE-----EMSEQTPGPLPLSYEQIRVALQDA 644
+ L+ED LR + EE+L E + L L +IR +D
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVE----EEILALKASFEKAAAGKAELELELGRIRSNAEDT 1962
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSL 704
++ L E A + + R AE A EEAA A L E++ L
Sbjct: 1963 LRSKEQAEL---EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERL 2018
Query: 705 SNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFA---------------TQRSLEQHQR 749
V+ R E A L + L A Q++L+Q Q
Sbjct: 2019 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Query: 750 LFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ L G + A + ++Q ++Q + EA R + E +
Sbjct: 2079 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQ 2128
Score = 53.5 bits (127), Expect = 9e-07
Identities = 145/632 (22%), Positives = 233/632 (36%), Gaps = 117/632 (18%)
Query: 257 QAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQL-RQDVEDRL 315
+A+R L L E Q S Q A + + E A+ K +E R +L Q++E +
Sbjct: 1644 EALR-LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702
Query: 316 HAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLV-LATPGAGARPEPDSLQARLG 374
T + ++ Q + + + Q+ L L A A + L+A L
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762
Query: 375 QLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSES--------------- 419
+++ + L + AR EEE + T E + L +EL E+
Sbjct: 1763 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1822
Query: 420 ---DETFDQISKVERQV-EELQVNHTALR---ELRVILMEKSLIME-------------- 458
++ Q ++ ER + E+L A R E + L EK E
Sbjct: 1823 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1882
Query: 459 -------ENKEEVERQLLEL----NLTLQHLQGGHADLIKYVKDCNCQKLYL-------- 499
++K ++E +L +L + L+ +G D ++ + + L L
Sbjct: 1883 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1942
Query: 500 --------DLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHK 551
+L IR D R+ E+ ++ +RQL + + A + V ++
Sbjct: 1943 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL---A 1999
Query: 552 AEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLA 611
AE E AR Q +A +EV LKA EAR + A L+ L EA
Sbjct: 2000 AEEEAAR--------QRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQEAAQK 2049
Query: 612 ALFGEEVLEEMS-EQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELA--ARVTALEQA 668
L EE + +Q L + +Q + L D G E A E A ARV A +A
Sbjct: 2050 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVL-DQLRGEAEAARRAAEEAEEARVQAEREA 2108
Query: 669 SEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
++ R E E + E+A A A A E + + E EA A + A
Sbjct: 2109 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAE---------KLRKEAEQEAARRAQAEQA 2159
Query: 729 SLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDL 788
+L A +E+H++ F +A V +L L+ L QK+L
Sbjct: 2160 ALRQKQ----AADAEMEKHKK-----FAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNL 2208
Query: 789 -------------EAPRKRDKKEAEPLVDIRV 807
EA R+R + E E L +RV
Sbjct: 2209 LDEELQRLKAEATEAARQRSQVE-EELFSVRV 2239
Score = 47.4 bits (111), Expect = 6e-05
Identities = 103/542 (19%), Positives = 198/542 (36%), Gaps = 39/542 (7%)
Query: 267 EANRQAISRVQDSAVARADFQELGAKFEAKVQENT-QRVGQLRQDVEDRLHAQHFTLHRS 325
E+ RQ + Q++A R +E F + +E Q+ Q Q V D+L + R+
Sbjct: 2035 ESARQ-LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2093
Query: 326 ISELQ-ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELH 384
E + A V + + ++ A A AR + + +L + E
Sbjct: 2094 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK------EAE 2147
Query: 385 MTTARREEELQYTLEDMRAT---LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHT 441
ARR + Q L +A + +H ++ + + +++ + Q+EE
Sbjct: 2148 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2207
Query: 442 ALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHL-------QGGHADLIKYVKDCNC 494
L E L ++ + +VE +L + + ++ L + + LI KD
Sbjct: 2208 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2267
Query: 495 QKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEG 554
+ L + + +++ +A R Q + R+ + Q A + + A + E
Sbjct: 2268 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EA 2326
Query: 555 ERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALF 614
R +A L+ Q + ++ L+ + ++ + F LE + + ++A
Sbjct: 2327 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2386
Query: 615 GEEVLE--EMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPP 672
L EMS + ++ R ++ L L E V LE
Sbjct: 2387 ERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE------ 2439
Query: 673 RPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHG 732
+ + HDA E A+A L RE + L + K + E L
Sbjct: 2440 --IQRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494
Query: 733 LHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPR 792
L + + + SL Q +R + L + V+ K Q L + ++QQ+ +E R
Sbjct: 2495 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQ-QLREEQQRQQQQMEQER 2549
Query: 793 KR 794
+R
Sbjct: 2550 QR 2551
Score = 40.4 bits (93), Expect = 0.008
Identities = 69/341 (20%), Positives = 144/341 (42%), Gaps = 32/341 (9%)
Query: 270 RQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISEL 329
++ + VQ++ +A+ + L + E QE +R+ + ++ + +L + R+ L
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRT---L 2372
Query: 330 QADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTAR 389
+A+ +L+ +A+ V A AR E D+ + R Q + +LH T
Sbjct: 2373 EAERQRQLEMSAEAERLK----LRVAEMSRAQARAEEDAQRFRK-QAEEIGEKLHRTELA 2427
Query: 390 REEE--LQYTLEDMRATLTRHVDEIKELYSESDETFDQISK----VERQVEELQV--NHT 441
+E+ L TLE R + ++E +E + +++ + ++ + EE+Q
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2487
Query: 442 ALRELRVI----------LMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKD 491
L+E + + L+++ +E+ K ++E+ + Q L+ + ++
Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 492 CNCQKLYLDLDVIREGQRDAT----RALEETQVSLDERRQLDGSSLQALQNAVDAVSLAV 547
Q+L ++ R Q +A R EE Q +RRQ + + Q + + L
Sbjct: 2548 -ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2606
Query: 548 DAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE 588
+ H+A + T+ + + L + AL AAEA E
Sbjct: 2607 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2647
Score = 39.3 bits (90), Expect = 0.018
Identities = 111/590 (18%), Positives = 218/590 (36%), Gaps = 76/590 (12%)
Query: 226 EQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARAD 285
E+VL H + + P + L + +++ L EA + ++D
Sbjct: 1106 EEVLRAHEEQLKEAQAVP---ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGA-- 1160
Query: 286 FQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQE 345
QE+G + + + E V + R+ V L L ++ Q +++ ++L +E
Sbjct: 1161 -QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRE 1218
Query: 346 APGTNGSLVLATPGAGARPEPDSLQAR-LGQLQRNLSELHMTTARREEELQYTLEDMRAT 404
+ G+ + AR + +QA L Q +L A EE
Sbjct: 1219 SADPLGAWL-----QDARRRQEQIQAMPLADSQAVREQLRQEQALLEE------------ 1261
Query: 405 LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV 464
+ RH ++++E + + + I E Q+ V + A E V K ++ E V
Sbjct: 1262 IERHGEKVEECQRFAKQYINAIKDYELQL----VTYKAQLE-PVASPAKKPKVQSGSESV 1316
Query: 465 ERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDE 524
++ ++L L + IK++ + R +EE + ++
Sbjct: 1317 IQEYVDLRTHYSELTTLTSQYIKFISE-------------------TLRRMEEEERLAEQ 1357
Query: 525 RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAE 584
+R + L ++ A++ +AH +A L+ ++Q +EV + AA +
Sbjct: 1358 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVD 1414
Query: 585 ARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDA 644
A+ + R + L + + EA + A + E S E+IRV
Sbjct: 1415 AQQQKRSIQEELQQLRQSS---EAEIQAKARQAEAAERSRLR------IEEEIRVVRLQL 1465
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAE------HLEPSHDAGREEAATTALAG-- 696
+ +++ EL A E+A R A+ + ++ R+ A LA
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1525
Query: 697 -----LARELQSLSNDVKNVG-RCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRL 750
ARE Q ++ + + EAE A + + + AL QRS E +
Sbjct: 1526 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA-RQVQVALETAQRSAEAELQS 1584
Query: 751 FHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ F +E ++ + + + ++ Q+ EA R R++ E E
Sbjct: 1585 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1634
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 63.5 bits (153), Expect = 9e-10
Identities = 132/560 (23%), Positives = 224/560 (40%), Gaps = 90/560 (16%)
Query: 267 EANRQAI-SRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRS 325
E QA+ +R +++ + QE + +VQ+ +QR Q ++ R+ A+
Sbjct: 1472 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1531
Query: 326 ISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHM 385
LQA + +L+ A+EA +R L + +
Sbjct: 1532 QRALQALEELRLQ----AEEA------------------------------ERRLRQAEV 1557
Query: 386 TTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRE 445
AR ++Q LE T R + EL S+ ++ +++ER ++E V LRE
Sbjct: 1558 ERAR---QVQVALE----TAQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608
Query: 446 LRVILMEKSLIMEENKEEVERQL----LELNLTLQ-HLQGGHADLIKYVKDCNC--QKLY 498
++ E +EE ER+L L+ N L+ LQ K + QK
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Query: 499 LDLDVIREG--QRDATRALEETQVSLDERRQL-DGSSLQALQNAVDAVSLAVDAHKAEGE 555
+ + R G + A R E + L+++RQL +G++ Q L A + E
Sbjct: 1669 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL------------AAEQELI 1716
Query: 556 RARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAA-LF 614
R RA T + Q Q L++E+ L+ AA A + ++L + A + + E +LA+
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM---EVLLASKAR 1773
Query: 615 GEEVLEEMSEQTPGPLPLSYEQIRVALQDAA--SGLQEQALGWDELAARVTALEQASEPP 672
EE SE++ L + R ++AA L E+A +LA A ++A
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1833
Query: 673 RPAEHLEPSHDAGR----EEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
AE L +A R E A L+ L+ D R E +A A +
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1893
Query: 729 SLHGLHNA-----------LFATQRSLEQHQRLFHSLFGNFQ--GLMEANVSLDLGKLQT 775
L L A + T R Q + +L +F+ +A + L+LG++++
Sbjct: 1894 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1953
Query: 776 ML-SRKGKKQQKDLEAPRKR 794
K+Q +LEA R+R
Sbjct: 1954 NAEDTLRSKEQAELEAARQR 1973
Score = 59.7 bits (143), Expect = 1e-08
Identities = 129/591 (21%), Positives = 216/591 (36%), Gaps = 77/591 (13%)
Query: 265 DVEANRQ---AISRVQDSAVA-----RADFQELGAKFEAKVQENTQRVGQLRQDVEDRLH 316
+VE RQ A+ Q SA A RA F E A+ E +QE V QLR++ E R
Sbjct: 1556 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1615
Query: 317 AQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQL 376
Q R+ E + +++ + ++A + A A E +A
Sbjct: 1616 -QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Query: 377 QRNLSELHMTTARR--EEELQYTLEDMRATLTRHV---DEIKELYSESDETFDQISKVER 431
+R +E R E+EL+ + T + + E+ L +E+++ Q +E
Sbjct: 1675 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1734
Query: 432 QVEELQVNHTAL---------------RELRVILMEKSLIMEENK--EEVERQLLELNL- 473
++ LQ A E+ V+L K+ EE++ E +Q LE
Sbjct: 1735 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1794
Query: 474 TLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSL 533
+ L A L ++ Q+ + D R+ + +A R L E ++ E +L +
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEA- 1852
Query: 534 QALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLH 593
+A+ +AE ER R Q + L+++ KA E ++R+
Sbjct: 1853 ----------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 594 SA----FAALLEDALRHEAVLAALFGEEVLE-----EMSEQTPGPLPLSYEQIRVALQDA 644
+ L+ED LR + EE+L E + L L +IR +D
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVE----EEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSL 704
++ L E A + + R AE A EEAA A L E++ L
Sbjct: 1959 LRSKEQAEL---EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERL 2014
Query: 705 SNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFA---------------TQRSLEQHQR 749
V+ R E A L + L A Q++L+Q Q
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 750 LFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ L G + A + ++Q ++Q + EA R + E +
Sbjct: 2075 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQ 2124
Score = 53.5 bits (127), Expect = 9e-07
Identities = 145/632 (22%), Positives = 233/632 (36%), Gaps = 117/632 (18%)
Query: 257 QAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQL-RQDVEDRL 315
+A+R L L E Q S Q A + + E A+ K +E R +L Q++E +
Sbjct: 1640 EALR-LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 316 HAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLV-LATPGAGARPEPDSLQARLG 374
T + ++ Q + + + Q+ L L A A + L+A L
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 375 QLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSES--------------- 419
+++ + L + AR EEE + T E + L +EL E+
Sbjct: 1759 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1818
Query: 420 ---DETFDQISKVERQV-EELQVNHTALR---ELRVILMEKSLIME-------------- 458
++ Q ++ ER + E+L A R E + L EK E
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1878
Query: 459 -------ENKEEVERQLLEL----NLTLQHLQGGHADLIKYVKDCNCQKLYL-------- 499
++K ++E +L +L + L+ +G D ++ + + L L
Sbjct: 1879 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1938
Query: 500 --------DLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHK 551
+L IR D R+ E+ ++ +RQL + + A + V ++
Sbjct: 1939 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL---A 1995
Query: 552 AEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLA 611
AE E AR Q +A +EV LKA EAR + A L+ L EA
Sbjct: 1996 AEEEAAR--------QRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQEAAQK 2045
Query: 612 ALFGEEVLEEMS-EQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELA--ARVTALEQA 668
L EE + +Q L + +Q + L D G E A E A ARV A +A
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVL-DQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 669 SEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
++ R E E + E+A A A A E + + E EA A + A
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAE---------KLRKEAEQEAARRAQAEQA 2155
Query: 729 SLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDL 788
+L A +E+H++ F +A V +L L+ L QK+L
Sbjct: 2156 ALRQKQ----AADAEMEKHKK-----FAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNL 2204
Query: 789 -------------EAPRKRDKKEAEPLVDIRV 807
EA R+R + E E L +RV
Sbjct: 2205 LDEELQRLKAEATEAARQRSQVE-EELFSVRV 2235
Score = 47.4 bits (111), Expect = 6e-05
Identities = 103/542 (19%), Positives = 198/542 (36%), Gaps = 39/542 (7%)
Query: 267 EANRQAISRVQDSAVARADFQELGAKFEAKVQENT-QRVGQLRQDVEDRLHAQHFTLHRS 325
E+ RQ + Q++A R +E F + +E Q+ Q Q V D+L + R+
Sbjct: 2031 ESARQ-LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2089
Query: 326 ISELQ-ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELH 384
E + A V + + ++ A A AR + + +L + E
Sbjct: 2090 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK------EAE 2143
Query: 385 MTTARREEELQYTLEDMRAT---LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHT 441
ARR + Q L +A + +H ++ + + +++ + Q+EE
Sbjct: 2144 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203
Query: 442 ALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHL-------QGGHADLIKYVKDCNC 494
L E L ++ + +VE +L + + ++ L + + LI KD
Sbjct: 2204 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2263
Query: 495 QKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEG 554
+ L + + +++ +A R Q + R+ + Q A + + A + E
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EA 2322
Query: 555 ERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALF 614
R +A L+ Q + ++ L+ + ++ + F LE + + ++A
Sbjct: 2323 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 615 GEEVLE--EMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPP 672
L EMS + ++ R ++ L L E V LE
Sbjct: 2383 ERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE------ 2435
Query: 673 RPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHG 732
+ + HDA E A+A L RE + L + K + E L
Sbjct: 2436 --IQRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 733 LHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPR 792
L + + + SL Q +R + L + V+ K Q L + ++QQ+ +E R
Sbjct: 2491 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQ-QLREEQQRQQQQMEQER 2545
Query: 793 KR 794
+R
Sbjct: 2546 QR 2547
Score = 40.4 bits (93), Expect = 0.008
Identities = 69/341 (20%), Positives = 144/341 (42%), Gaps = 32/341 (9%)
Query: 270 RQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISEL 329
++ + VQ++ +A+ + L + E QE +R+ + ++ + +L + R+ L
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRT---L 2368
Query: 330 QADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTAR 389
+A+ +L+ +A+ V A AR E D+ + R Q + +LH T
Sbjct: 2369 EAERQRQLEMSAEAERLK----LRVAEMSRAQARAEEDAQRFRK-QAEEIGEKLHRTELA 2423
Query: 390 REEE--LQYTLEDMRATLTRHVDEIKELYSESDETFDQISK----VERQVEELQV--NHT 441
+E+ L TLE R + ++E +E + +++ + ++ + EE+Q
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 442 ALRELRVI----------LMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKD 491
L+E + + L+++ +E+ K ++E+ + Q L+ + ++
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 492 CNCQKLYLDLDVIREGQRDAT----RALEETQVSLDERRQLDGSSLQALQNAVDAVSLAV 547
Q+L ++ R Q +A R EE Q +RRQ + + Q + + L
Sbjct: 2544 -ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Query: 548 DAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE 588
+ H+A + T+ + + L + AL AAEA E
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643
Score = 39.3 bits (90), Expect = 0.018
Identities = 111/590 (18%), Positives = 218/590 (36%), Gaps = 76/590 (12%)
Query: 226 EQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARAD 285
E+VL H + + P + L + +++ L EA + ++D
Sbjct: 1102 EEVLRAHEEQLKEAQAVP---ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGA-- 1156
Query: 286 FQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQE 345
QE+G + + + E V + R+ V L L ++ Q +++ ++L +E
Sbjct: 1157 -QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRE 1214
Query: 346 APGTNGSLVLATPGAGARPEPDSLQAR-LGQLQRNLSELHMTTARREEELQYTLEDMRAT 404
+ G+ + AR + +QA L Q +L A EE
Sbjct: 1215 SADPLGAWL-----QDARRRQEQIQAMPLADSQAVREQLRQEQALLEE------------ 1257
Query: 405 LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV 464
+ RH ++++E + + + I E Q+ V + A E V K ++ E V
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQL----VTYKAQLE-PVASPAKKPKVQSGSESV 1312
Query: 465 ERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDE 524
++ ++L L + IK++ + R +EE + ++
Sbjct: 1313 IQEYVDLRTHYSELTTLTSQYIKFISE-------------------TLRRMEEEERLAEQ 1353
Query: 525 RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAE 584
+R + L ++ A++ +AH +A L+ ++Q +EV + AA +
Sbjct: 1354 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVD 1410
Query: 585 ARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDA 644
A+ + R + L + + EA + A + E S E+IRV
Sbjct: 1411 AQQQKRSIQEELQQLRQSS---EAEIQAKARQAEAAERSRLR------IEEEIRVVRLQL 1461
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAE------HLEPSHDAGREEAATTALAG-- 696
+ +++ EL A E+A R A+ + ++ R+ A LA
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1521
Query: 697 -----LARELQSLSNDVKNVG-RCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRL 750
ARE Q ++ + + EAE A + + + AL QRS E +
Sbjct: 1522 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA-RQVQVALETAQRSAEAELQS 1580
Query: 751 FHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ F +E ++ + + + ++ Q+ EA R R++ E E
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1630
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 63.5 bits (153), Expect = 9e-10
Identities = 132/560 (23%), Positives = 224/560 (40%), Gaps = 90/560 (16%)
Query: 267 EANRQAI-SRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRS 325
E QA+ +R +++ + QE + +VQ+ +QR Q ++ R+ A+
Sbjct: 1440 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1499
Query: 326 ISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHM 385
LQA + +L+ A+EA +R L + +
Sbjct: 1500 QRALQALEELRLQ----AEEA------------------------------ERRLRQAEV 1525
Query: 386 TTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRE 445
AR ++Q LE T R + EL S+ ++ +++ER ++E V LRE
Sbjct: 1526 ERAR---QVQVALE----TAQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1576
Query: 446 LRVILMEKSLIMEENKEEVERQL----LELNLTLQ-HLQGGHADLIKYVKDCNC--QKLY 498
++ E +EE ER+L L+ N L+ LQ K + QK
Sbjct: 1577 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636
Query: 499 LDLDVIREG--QRDATRALEETQVSLDERRQL-DGSSLQALQNAVDAVSLAVDAHKAEGE 555
+ + R G + A R E + L+++RQL +G++ Q L A + E
Sbjct: 1637 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL------------AAEQELI 1684
Query: 556 RARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAA-LF 614
R RA T + Q Q L++E+ L+ AA A + ++L + A + + E +LA+
Sbjct: 1685 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM---EVLLASKAR 1741
Query: 615 GEEVLEEMSEQTPGPLPLSYEQIRVALQDAA--SGLQEQALGWDELAARVTALEQASEPP 672
EE SE++ L + R ++AA L E+A +LA A ++A
Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1801
Query: 673 RPAEHLEPSHDAGR----EEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
AE L +A R E A L+ L+ D R E +A A +
Sbjct: 1802 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1861
Query: 729 SLHGLHNA-----------LFATQRSLEQHQRLFHSLFGNFQ--GLMEANVSLDLGKLQT 775
L L A + T R Q + +L +F+ +A + L+LG++++
Sbjct: 1862 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1921
Query: 776 ML-SRKGKKQQKDLEAPRKR 794
K+Q +LEA R+R
Sbjct: 1922 NAEDTLRSKEQAELEAARQR 1941
Score = 59.7 bits (143), Expect = 1e-08
Identities = 129/591 (21%), Positives = 216/591 (36%), Gaps = 77/591 (13%)
Query: 265 DVEANRQ---AISRVQDSAVA-----RADFQELGAKFEAKVQENTQRVGQLRQDVEDRLH 316
+VE RQ A+ Q SA A RA F E A+ E +QE V QLR++ E R
Sbjct: 1524 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1583
Query: 317 AQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQL 376
Q R+ E + +++ + ++A + A A E +A
Sbjct: 1584 -QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1642
Query: 377 QRNLSELHMTTARR--EEELQYTLEDMRATLTRHV---DEIKELYSESDETFDQISKVER 431
+R +E R E+EL+ + T + + E+ L +E+++ Q +E
Sbjct: 1643 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1702
Query: 432 QVEELQVNHTAL---------------RELRVILMEKSLIMEENK--EEVERQLLELNL- 473
++ LQ A E+ V+L K+ EE++ E +Q LE
Sbjct: 1703 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1762
Query: 474 TLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSL 533
+ L A L ++ Q+ + D R+ + +A R L E ++ E +L +
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEA- 1820
Query: 534 QALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLH 593
+A+ +AE ER R Q + L+++ KA E ++R+
Sbjct: 1821 ----------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1870
Query: 594 SA----FAALLEDALRHEAVLAALFGEEVLE-----EMSEQTPGPLPLSYEQIRVALQDA 644
+ L+ED LR + EE+L E + L L +IR +D
Sbjct: 1871 DSELERQKGLVEDTLRQRRQVE----EEILALKASFEKAAAGKAELELELGRIRSNAEDT 1926
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSL 704
++ L E A + + R AE A EEAA A L E++ L
Sbjct: 1927 LRSKEQAEL---EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERL 1982
Query: 705 SNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFA---------------TQRSLEQHQR 749
V+ R E A L + L A Q++L+Q Q
Sbjct: 1983 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Query: 750 LFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ L G + A + ++Q ++Q + EA R + E +
Sbjct: 2043 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQ 2092
Score = 53.5 bits (127), Expect = 9e-07
Identities = 145/632 (22%), Positives = 233/632 (36%), Gaps = 117/632 (18%)
Query: 257 QAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQL-RQDVEDRL 315
+A+R L L E Q S Q A + + E A+ K +E R +L Q++E +
Sbjct: 1608 EALR-LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666
Query: 316 HAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLV-LATPGAGARPEPDSLQARLG 374
T + ++ Q + + + Q+ L L A A + L+A L
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726
Query: 375 QLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSES--------------- 419
+++ + L + AR EEE + T E + L +EL E+
Sbjct: 1727 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1786
Query: 420 ---DETFDQISKVERQV-EELQVNHTALR---ELRVILMEKSLIME-------------- 458
++ Q ++ ER + E+L A R E + L EK E
Sbjct: 1787 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1846
Query: 459 -------ENKEEVERQLLEL----NLTLQHLQGGHADLIKYVKDCNCQKLYL-------- 499
++K ++E +L +L + L+ +G D ++ + + L L
Sbjct: 1847 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1906
Query: 500 --------DLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHK 551
+L IR D R+ E+ ++ +RQL + + A + V ++
Sbjct: 1907 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL---A 1963
Query: 552 AEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLA 611
AE E AR Q +A +EV LKA EAR + A L+ L EA
Sbjct: 1964 AEEEAAR--------QRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQEAAQK 2013
Query: 612 ALFGEEVLEEMS-EQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELA--ARVTALEQA 668
L EE + +Q L + +Q + L D G E A E A ARV A +A
Sbjct: 2014 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVL-DQLRGEAEAARRAAEEAEEARVQAEREA 2072
Query: 669 SEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
++ R E E + E+A A A A E + + E EA A + A
Sbjct: 2073 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAE---------KLRKEAEQEAARRAQAEQA 2123
Query: 729 SLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDL 788
+L A +E+H++ F +A V +L L+ L QK+L
Sbjct: 2124 ALRQKQ----AADAEMEKHKK-----FAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNL 2172
Query: 789 -------------EAPRKRDKKEAEPLVDIRV 807
EA R+R + E E L +RV
Sbjct: 2173 LDEELQRLKAEATEAARQRSQVE-EELFSVRV 2203
Score = 47.4 bits (111), Expect = 6e-05
Identities = 103/542 (19%), Positives = 198/542 (36%), Gaps = 39/542 (7%)
Query: 267 EANRQAISRVQDSAVARADFQELGAKFEAKVQENT-QRVGQLRQDVEDRLHAQHFTLHRS 325
E+ RQ + Q++A R +E F + +E Q+ Q Q V D+L + R+
Sbjct: 1999 ESARQ-LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2057
Query: 326 ISELQ-ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELH 384
E + A V + + ++ A A AR + + +L + E
Sbjct: 2058 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK------EAE 2111
Query: 385 MTTARREEELQYTLEDMRAT---LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHT 441
ARR + Q L +A + +H ++ + + +++ + Q+EE
Sbjct: 2112 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2171
Query: 442 ALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHL-------QGGHADLIKYVKDCNC 494
L E L ++ + +VE +L + + ++ L + + LI KD
Sbjct: 2172 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2231
Query: 495 QKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEG 554
+ L + + +++ +A R Q + R+ + Q A + + A + E
Sbjct: 2232 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EA 2290
Query: 555 ERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALF 614
R +A L+ Q + ++ L+ + ++ + F LE + + ++A
Sbjct: 2291 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2350
Query: 615 GEEVLE--EMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPP 672
L EMS + ++ R ++ L L E V LE
Sbjct: 2351 ERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE------ 2403
Query: 673 RPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHG 732
+ + HDA E A+A L RE + L + K + E L
Sbjct: 2404 --IQRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458
Query: 733 LHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPR 792
L + + + SL Q +R + L + V+ K Q L + ++QQ+ +E R
Sbjct: 2459 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQ-QLREEQQRQQQQMEQER 2513
Query: 793 KR 794
+R
Sbjct: 2514 QR 2515
Score = 40.4 bits (93), Expect = 0.008
Identities = 69/341 (20%), Positives = 144/341 (42%), Gaps = 32/341 (9%)
Query: 270 RQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISEL 329
++ + VQ++ +A+ + L + E QE +R+ + ++ + +L + R+ L
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRT---L 2336
Query: 330 QADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTAR 389
+A+ +L+ +A+ V A AR E D+ + R Q + +LH T
Sbjct: 2337 EAERQRQLEMSAEAERLK----LRVAEMSRAQARAEEDAQRFRK-QAEEIGEKLHRTELA 2391
Query: 390 REEE--LQYTLEDMRATLTRHVDEIKELYSESDETFDQISK----VERQVEELQV--NHT 441
+E+ L TLE R + ++E +E + +++ + ++ + EE+Q
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2451
Query: 442 ALRELRVI----------LMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKD 491
L+E + + L+++ +E+ K ++E+ + Q L+ + ++
Sbjct: 2452 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 492 CNCQKLYLDLDVIREGQRDAT----RALEETQVSLDERRQLDGSSLQALQNAVDAVSLAV 547
Q+L ++ R Q +A R EE Q +RRQ + + Q + + L
Sbjct: 2512 -ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2570
Query: 548 DAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE 588
+ H+A + T+ + + L + AL AAEA E
Sbjct: 2571 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2611
Score = 39.3 bits (90), Expect = 0.018
Identities = 111/590 (18%), Positives = 218/590 (36%), Gaps = 76/590 (12%)
Query: 226 EQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARAD 285
E+VL H + + P + L + +++ L EA + ++D
Sbjct: 1070 EEVLRAHEEQLKEAQAVP---ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGA-- 1124
Query: 286 FQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQE 345
QE+G + + + E V + R+ V L L ++ Q +++ ++L +E
Sbjct: 1125 -QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRE 1182
Query: 346 APGTNGSLVLATPGAGARPEPDSLQAR-LGQLQRNLSELHMTTARREEELQYTLEDMRAT 404
+ G+ + AR + +QA L Q +L A EE
Sbjct: 1183 SADPLGAWL-----QDARRRQEQIQAMPLADSQAVREQLRQEQALLEE------------ 1225
Query: 405 LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV 464
+ RH ++++E + + + I E Q+ V + A E V K ++ E V
Sbjct: 1226 IERHGEKVEECQRFAKQYINAIKDYELQL----VTYKAQLE-PVASPAKKPKVQSGSESV 1280
Query: 465 ERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDE 524
++ ++L L + IK++ + R +EE + ++
Sbjct: 1281 IQEYVDLRTHYSELTTLTSQYIKFISE-------------------TLRRMEEEERLAEQ 1321
Query: 525 RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAE 584
+R + L ++ A++ +AH +A L+ ++Q +EV + AA +
Sbjct: 1322 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVD 1378
Query: 585 ARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDA 644
A+ + R + L + + EA + A + E S E+IRV
Sbjct: 1379 AQQQKRSIQEELQQLRQSS---EAEIQAKARQAEAAERSRLR------IEEEIRVVRLQL 1429
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAE------HLEPSHDAGREEAATTALAG-- 696
+ +++ EL A E+A R A+ + ++ R+ A LA
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1489
Query: 697 -----LARELQSLSNDVKNVG-RCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRL 750
ARE Q ++ + + EAE A + + + AL QRS E +
Sbjct: 1490 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA-RQVQVALETAQRSAEAELQS 1548
Query: 751 FHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ F +E ++ + + + ++ Q+ EA R R++ E E
Sbjct: 1549 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1598
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 63.5 bits (153), Expect = 9e-10
Identities = 132/560 (23%), Positives = 224/560 (40%), Gaps = 90/560 (16%)
Query: 267 EANRQAI-SRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRS 325
E QA+ +R +++ + QE + +VQ+ +QR Q ++ R+ A+
Sbjct: 1609 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1668
Query: 326 ISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHM 385
LQA + +L+ A+EA +R L + +
Sbjct: 1669 QRALQALEELRLQ----AEEA------------------------------ERRLRQAEV 1694
Query: 386 TTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRE 445
AR ++Q LE T R + EL S+ ++ +++ER ++E V LRE
Sbjct: 1695 ERAR---QVQVALE----TAQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1745
Query: 446 LRVILMEKSLIMEENKEEVERQL----LELNLTLQ-HLQGGHADLIKYVKDCNC--QKLY 498
++ E +EE ER+L L+ N L+ LQ K + QK
Sbjct: 1746 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805
Query: 499 LDLDVIREG--QRDATRALEETQVSLDERRQL-DGSSLQALQNAVDAVSLAVDAHKAEGE 555
+ + R G + A R E + L+++RQL +G++ Q L A + E
Sbjct: 1806 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL------------AAEQELI 1853
Query: 556 RARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAA-LF 614
R RA T + Q Q L++E+ L+ AA A + ++L + A + + E +LA+
Sbjct: 1854 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM---EVLLASKAR 1910
Query: 615 GEEVLEEMSEQTPGPLPLSYEQIRVALQDAA--SGLQEQALGWDELAARVTALEQASEPP 672
EE SE++ L + R ++AA L E+A +LA A ++A
Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1970
Query: 673 RPAEHLEPSHDAGR----EEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
AE L +A R E A L+ L+ D R E +A A +
Sbjct: 1971 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 2030
Query: 729 SLHGLHNA-----------LFATQRSLEQHQRLFHSLFGNFQ--GLMEANVSLDLGKLQT 775
L L A + T R Q + +L +F+ +A + L+LG++++
Sbjct: 2031 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 2090
Query: 776 ML-SRKGKKQQKDLEAPRKR 794
K+Q +LEA R+R
Sbjct: 2091 NAEDTLRSKEQAELEAARQR 2110
Score = 59.7 bits (143), Expect = 1e-08
Identities = 129/591 (21%), Positives = 216/591 (36%), Gaps = 77/591 (13%)
Query: 265 DVEANRQ---AISRVQDSAVA-----RADFQELGAKFEAKVQENTQRVGQLRQDVEDRLH 316
+VE RQ A+ Q SA A RA F E A+ E +QE V QLR++ E R
Sbjct: 1693 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752
Query: 317 AQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQL 376
Q R+ E + +++ + ++A + A A E +A
Sbjct: 1753 -QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1811
Query: 377 QRNLSELHMTTARR--EEELQYTLEDMRATLTRHV---DEIKELYSESDETFDQISKVER 431
+R +E R E+EL+ + T + + E+ L +E+++ Q +E
Sbjct: 1812 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1871
Query: 432 QVEELQVNHTAL---------------RELRVILMEKSLIMEENK--EEVERQLLELNL- 473
++ LQ A E+ V+L K+ EE++ E +Q LE
Sbjct: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931
Query: 474 TLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSL 533
+ L A L ++ Q+ + D R+ + +A R L E ++ E +L +
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEA- 1989
Query: 534 QALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLH 593
+A+ +AE ER R Q + L+++ KA E ++R+
Sbjct: 1990 ----------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 2039
Query: 594 SA----FAALLEDALRHEAVLAALFGEEVLE-----EMSEQTPGPLPLSYEQIRVALQDA 644
+ L+ED LR + EE+L E + L L +IR +D
Sbjct: 2040 DSELERQKGLVEDTLRQRRQVE----EEILALKASFEKAAAGKAELELELGRIRSNAEDT 2095
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSL 704
++ L E A + + R AE A EEAA A L E++ L
Sbjct: 2096 LRSKEQAEL---EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERL 2151
Query: 705 SNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFA---------------TQRSLEQHQR 749
V+ R E A L + L A Q++L+Q Q
Sbjct: 2152 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Query: 750 LFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ L G + A + ++Q ++Q + EA R + E +
Sbjct: 2212 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQ 2261
Score = 53.5 bits (127), Expect = 9e-07
Identities = 145/632 (22%), Positives = 233/632 (36%), Gaps = 117/632 (18%)
Query: 257 QAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQL-RQDVEDRL 315
+A+R L L E Q S Q A + + E A+ K +E R +L Q++E +
Sbjct: 1777 EALR-LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835
Query: 316 HAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLV-LATPGAGARPEPDSLQARLG 374
T + ++ Q + + + Q+ L L A A + L+A L
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895
Query: 375 QLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSES--------------- 419
+++ + L + AR EEE + T E + L +EL E+
Sbjct: 1896 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1955
Query: 420 ---DETFDQISKVERQV-EELQVNHTALR---ELRVILMEKSLIME-------------- 458
++ Q ++ ER + E+L A R E + L EK E
Sbjct: 1956 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 2015
Query: 459 -------ENKEEVERQLLEL----NLTLQHLQGGHADLIKYVKDCNCQKLYL-------- 499
++K ++E +L +L + L+ +G D ++ + + L L
Sbjct: 2016 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 2075
Query: 500 --------DLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHK 551
+L IR D R+ E+ ++ +RQL + + A + V ++
Sbjct: 2076 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL---A 2132
Query: 552 AEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLA 611
AE E AR Q +A +EV LKA EAR + A L+ L EA
Sbjct: 2133 AEEEAAR--------QRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQEAAQK 2182
Query: 612 ALFGEEVLEEMS-EQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELA--ARVTALEQA 668
L EE + +Q L + +Q + L D G E A E A ARV A +A
Sbjct: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVL-DQLRGEAEAARRAAEEAEEARVQAEREA 2241
Query: 669 SEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
++ R E E + E+A A A A E + + E EA A + A
Sbjct: 2242 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAE---------KLRKEAEQEAARRAQAEQA 2292
Query: 729 SLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDL 788
+L A +E+H++ F +A V +L L+ L QK+L
Sbjct: 2293 ALRQKQ----AADAEMEKHKK-----FAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNL 2341
Query: 789 -------------EAPRKRDKKEAEPLVDIRV 807
EA R+R + E E L +RV
Sbjct: 2342 LDEELQRLKAEATEAARQRSQVE-EELFSVRV 2372
Score = 47.4 bits (111), Expect = 6e-05
Identities = 103/542 (19%), Positives = 198/542 (36%), Gaps = 39/542 (7%)
Query: 267 EANRQAISRVQDSAVARADFQELGAKFEAKVQENT-QRVGQLRQDVEDRLHAQHFTLHRS 325
E+ RQ + Q++A R +E F + +E Q+ Q Q V D+L + R+
Sbjct: 2168 ESARQ-LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2226
Query: 326 ISELQ-ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELH 384
E + A V + + ++ A A AR + + +L + E
Sbjct: 2227 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK------EAE 2280
Query: 385 MTTARREEELQYTLEDMRAT---LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHT 441
ARR + Q L +A + +H ++ + + +++ + Q+EE
Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340
Query: 442 ALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHL-------QGGHADLIKYVKDCNC 494
L E L ++ + +VE +L + + ++ L + + LI KD
Sbjct: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400
Query: 495 QKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEG 554
+ L + + +++ +A R Q + R+ + Q A + + A + E
Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EA 2459
Query: 555 ERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALF 614
R +A L+ Q + ++ L+ + ++ + F LE + + ++A
Sbjct: 2460 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519
Query: 615 GEEVLE--EMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPP 672
L EMS + ++ R ++ L L E V LE
Sbjct: 2520 ERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE------ 2572
Query: 673 RPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHG 732
+ + HDA E A+A L RE + L + K + E L
Sbjct: 2573 --IQRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627
Query: 733 LHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPR 792
L + + + SL Q +R + L + V+ K Q L + ++QQ+ +E R
Sbjct: 2628 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQ-QLREEQQRQQQQMEQER 2682
Query: 793 KR 794
+R
Sbjct: 2683 QR 2684
Score = 40.4 bits (93), Expect = 0.008
Identities = 69/341 (20%), Positives = 144/341 (42%), Gaps = 32/341 (9%)
Query: 270 RQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISEL 329
++ + VQ++ +A+ + L + E QE +R+ + ++ + +L + R+ L
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRT---L 2505
Query: 330 QADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTAR 389
+A+ +L+ +A+ V A AR E D+ + R Q + +LH T
Sbjct: 2506 EAERQRQLEMSAEAERLK----LRVAEMSRAQARAEEDAQRFRK-QAEEIGEKLHRTELA 2560
Query: 390 REEE--LQYTLEDMRATLTRHVDEIKELYSESDETFDQISK----VERQVEELQV--NHT 441
+E+ L TLE R + ++E +E + +++ + ++ + EE+Q
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2620
Query: 442 ALRELRVI----------LMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKD 491
L+E + + L+++ +E+ K ++E+ + Q L+ + ++
Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 492 CNCQKLYLDLDVIREGQRDAT----RALEETQVSLDERRQLDGSSLQALQNAVDAVSLAV 547
Q+L ++ R Q +A R EE Q +RRQ + + Q + + L
Sbjct: 2681 -ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2739
Query: 548 DAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE 588
+ H+A + T+ + + L + AL AAEA E
Sbjct: 2740 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2780
Score = 39.3 bits (90), Expect = 0.018
Identities = 111/590 (18%), Positives = 218/590 (36%), Gaps = 76/590 (12%)
Query: 226 EQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARAD 285
E+VL H + + P + L + +++ L EA + ++D
Sbjct: 1239 EEVLRAHEEQLKEAQAVP---ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGA-- 1293
Query: 286 FQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQE 345
QE+G + + + E V + R+ V L L ++ Q +++ ++L +E
Sbjct: 1294 -QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRE 1351
Query: 346 APGTNGSLVLATPGAGARPEPDSLQAR-LGQLQRNLSELHMTTARREEELQYTLEDMRAT 404
+ G+ + AR + +QA L Q +L A EE
Sbjct: 1352 SADPLGAWL-----QDARRRQEQIQAMPLADSQAVREQLRQEQALLEE------------ 1394
Query: 405 LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV 464
+ RH ++++E + + + I E Q+ V + A E V K ++ E V
Sbjct: 1395 IERHGEKVEECQRFAKQYINAIKDYELQL----VTYKAQLE-PVASPAKKPKVQSGSESV 1449
Query: 465 ERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDE 524
++ ++L L + IK++ + R +EE + ++
Sbjct: 1450 IQEYVDLRTHYSELTTLTSQYIKFISE-------------------TLRRMEEEERLAEQ 1490
Query: 525 RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAE 584
+R + L ++ A++ +AH +A L+ ++Q +EV + AA +
Sbjct: 1491 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVD 1547
Query: 585 ARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDA 644
A+ + R + L + + EA + A + E S E+IRV
Sbjct: 1548 AQQQKRSIQEELQQLRQSS---EAEIQAKARQAEAAERSRLR------IEEEIRVVRLQL 1598
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAE------HLEPSHDAGREEAATTALAG-- 696
+ +++ EL A E+A R A+ + ++ R+ A LA
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1658
Query: 697 -----LARELQSLSNDVKNVG-RCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRL 750
ARE Q ++ + + EAE A + + + AL QRS E +
Sbjct: 1659 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA-RQVQVALETAQRSAEAELQS 1717
Query: 751 FHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ F +E ++ + + + ++ Q+ EA R R++ E E
Sbjct: 1718 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1767
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 63.5 bits (153), Expect = 9e-10
Identities = 132/560 (23%), Positives = 224/560 (40%), Gaps = 90/560 (16%)
Query: 267 EANRQAI-SRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRS 325
E QA+ +R +++ + QE + +VQ+ +QR Q ++ R+ A+
Sbjct: 1450 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1509
Query: 326 ISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHM 385
LQA + +L+ A+EA +R L + +
Sbjct: 1510 QRALQALEELRLQ----AEEA------------------------------ERRLRQAEV 1535
Query: 386 TTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRE 445
AR ++Q LE T R + EL S+ ++ +++ER ++E V LRE
Sbjct: 1536 ERAR---QVQVALE----TAQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1586
Query: 446 LRVILMEKSLIMEENKEEVERQL----LELNLTLQ-HLQGGHADLIKYVKDCNC--QKLY 498
++ E +EE ER+L L+ N L+ LQ K + QK
Sbjct: 1587 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646
Query: 499 LDLDVIREG--QRDATRALEETQVSLDERRQL-DGSSLQALQNAVDAVSLAVDAHKAEGE 555
+ + R G + A R E + L+++RQL +G++ Q L A + E
Sbjct: 1647 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL------------AAEQELI 1694
Query: 556 RARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAA-LF 614
R RA T + Q Q L++E+ L+ AA A + ++L + A + + E +LA+
Sbjct: 1695 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM---EVLLASKAR 1751
Query: 615 GEEVLEEMSEQTPGPLPLSYEQIRVALQDAA--SGLQEQALGWDELAARVTALEQASEPP 672
EE SE++ L + R ++AA L E+A +LA A ++A
Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1811
Query: 673 RPAEHLEPSHDAGR----EEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
AE L +A R E A L+ L+ D R E +A A +
Sbjct: 1812 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1871
Query: 729 SLHGLHNA-----------LFATQRSLEQHQRLFHSLFGNFQ--GLMEANVSLDLGKLQT 775
L L A + T R Q + +L +F+ +A + L+LG++++
Sbjct: 1872 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1931
Query: 776 ML-SRKGKKQQKDLEAPRKR 794
K+Q +LEA R+R
Sbjct: 1932 NAEDTLRSKEQAELEAARQR 1951
Score = 59.7 bits (143), Expect = 1e-08
Identities = 129/591 (21%), Positives = 216/591 (36%), Gaps = 77/591 (13%)
Query: 265 DVEANRQ---AISRVQDSAVA-----RADFQELGAKFEAKVQENTQRVGQLRQDVEDRLH 316
+VE RQ A+ Q SA A RA F E A+ E +QE V QLR++ E R
Sbjct: 1534 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
Query: 317 AQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQL 376
Q R+ E + +++ + ++A + A A E +A
Sbjct: 1594 -QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1652
Query: 377 QRNLSELHMTTARR--EEELQYTLEDMRATLTRHV---DEIKELYSESDETFDQISKVER 431
+R +E R E+EL+ + T + + E+ L +E+++ Q +E
Sbjct: 1653 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1712
Query: 432 QVEELQVNHTAL---------------RELRVILMEKSLIMEENK--EEVERQLLELNL- 473
++ LQ A E+ V+L K+ EE++ E +Q LE
Sbjct: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772
Query: 474 TLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSL 533
+ L A L ++ Q+ + D R+ + +A R L E ++ E +L +
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEA- 1830
Query: 534 QALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLH 593
+A+ +AE ER R Q + L+++ KA E ++R+
Sbjct: 1831 ----------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1880
Query: 594 SA----FAALLEDALRHEAVLAALFGEEVLE-----EMSEQTPGPLPLSYEQIRVALQDA 644
+ L+ED LR + EE+L E + L L +IR +D
Sbjct: 1881 DSELERQKGLVEDTLRQRRQVE----EEILALKASFEKAAAGKAELELELGRIRSNAEDT 1936
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSL 704
++ L E A + + R AE A EEAA A L E++ L
Sbjct: 1937 LRSKEQAEL---EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERL 1992
Query: 705 SNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFA---------------TQRSLEQHQR 749
V+ R E A L + L A Q++L+Q Q
Sbjct: 1993 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Query: 750 LFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ L G + A + ++Q ++Q + EA R + E +
Sbjct: 2053 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQ 2102
Score = 53.5 bits (127), Expect = 9e-07
Identities = 145/632 (22%), Positives = 233/632 (36%), Gaps = 117/632 (18%)
Query: 257 QAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQL-RQDVEDRL 315
+A+R L L E Q S Q A + + E A+ K +E R +L Q++E +
Sbjct: 1618 EALR-LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676
Query: 316 HAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLV-LATPGAGARPEPDSLQARLG 374
T + ++ Q + + + Q+ L L A A + L+A L
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736
Query: 375 QLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSES--------------- 419
+++ + L + AR EEE + T E + L +EL E+
Sbjct: 1737 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1796
Query: 420 ---DETFDQISKVERQV-EELQVNHTALR---ELRVILMEKSLIME-------------- 458
++ Q ++ ER + E+L A R E + L EK E
Sbjct: 1797 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1856
Query: 459 -------ENKEEVERQLLEL----NLTLQHLQGGHADLIKYVKDCNCQKLYL-------- 499
++K ++E +L +L + L+ +G D ++ + + L L
Sbjct: 1857 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1916
Query: 500 --------DLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHK 551
+L IR D R+ E+ ++ +RQL + + A + V ++
Sbjct: 1917 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL---A 1973
Query: 552 AEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLA 611
AE E AR Q +A +EV LKA EAR + A L+ L EA
Sbjct: 1974 AEEEAAR--------QRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQEAAQK 2023
Query: 612 ALFGEEVLEEMS-EQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELA--ARVTALEQA 668
L EE + +Q L + +Q + L D G E A E A ARV A +A
Sbjct: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVL-DQLRGEAEAARRAAEEAEEARVQAEREA 2082
Query: 669 SEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
++ R E E + E+A A A A E + + E EA A + A
Sbjct: 2083 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAE---------KLRKEAEQEAARRAQAEQA 2133
Query: 729 SLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDL 788
+L A +E+H++ F +A V +L L+ L QK+L
Sbjct: 2134 ALRQKQ----AADAEMEKHKK-----FAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNL 2182
Query: 789 -------------EAPRKRDKKEAEPLVDIRV 807
EA R+R + E E L +RV
Sbjct: 2183 LDEELQRLKAEATEAARQRSQVE-EELFSVRV 2213
Score = 47.4 bits (111), Expect = 6e-05
Identities = 103/542 (19%), Positives = 198/542 (36%), Gaps = 39/542 (7%)
Query: 267 EANRQAISRVQDSAVARADFQELGAKFEAKVQENT-QRVGQLRQDVEDRLHAQHFTLHRS 325
E+ RQ + Q++A R +E F + +E Q+ Q Q V D+L + R+
Sbjct: 2009 ESARQ-LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2067
Query: 326 ISELQ-ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELH 384
E + A V + + ++ A A AR + + +L + E
Sbjct: 2068 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK------EAE 2121
Query: 385 MTTARREEELQYTLEDMRAT---LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHT 441
ARR + Q L +A + +H ++ + + +++ + Q+EE
Sbjct: 2122 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2181
Query: 442 ALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHL-------QGGHADLIKYVKDCNC 494
L E L ++ + +VE +L + + ++ L + + LI KD
Sbjct: 2182 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2241
Query: 495 QKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEG 554
+ L + + +++ +A R Q + R+ + Q A + + A + E
Sbjct: 2242 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EA 2300
Query: 555 ERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALF 614
R +A L+ Q + ++ L+ + ++ + F LE + + ++A
Sbjct: 2301 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360
Query: 615 GEEVLE--EMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPP 672
L EMS + ++ R ++ L L E V LE
Sbjct: 2361 ERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE------ 2413
Query: 673 RPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHG 732
+ + HDA E A+A L RE + L + K + E L
Sbjct: 2414 --IQRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468
Query: 733 LHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPR 792
L + + + SL Q +R + L + V+ K Q L + ++QQ+ +E R
Sbjct: 2469 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQ-QLREEQQRQQQQMEQER 2523
Query: 793 KR 794
+R
Sbjct: 2524 QR 2525
Score = 40.4 bits (93), Expect = 0.008
Identities = 69/341 (20%), Positives = 144/341 (42%), Gaps = 32/341 (9%)
Query: 270 RQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISEL 329
++ + VQ++ +A+ + L + E QE +R+ + ++ + +L + R+ L
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRT---L 2346
Query: 330 QADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTAR 389
+A+ +L+ +A+ V A AR E D+ + R Q + +LH T
Sbjct: 2347 EAERQRQLEMSAEAERLK----LRVAEMSRAQARAEEDAQRFRK-QAEEIGEKLHRTELA 2401
Query: 390 REEE--LQYTLEDMRATLTRHVDEIKELYSESDETFDQISK----VERQVEELQV--NHT 441
+E+ L TLE R + ++E +E + +++ + ++ + EE+Q
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2461
Query: 442 ALRELRVI----------LMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKD 491
L+E + + L+++ +E+ K ++E+ + Q L+ + ++
Sbjct: 2462 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 492 CNCQKLYLDLDVIREGQRDAT----RALEETQVSLDERRQLDGSSLQALQNAVDAVSLAV 547
Q+L ++ R Q +A R EE Q +RRQ + + Q + + L
Sbjct: 2522 -ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580
Query: 548 DAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE 588
+ H+A + T+ + + L + AL AAEA E
Sbjct: 2581 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2621
Score = 39.3 bits (90), Expect = 0.018
Identities = 111/590 (18%), Positives = 218/590 (36%), Gaps = 76/590 (12%)
Query: 226 EQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARAD 285
E+VL H + + P + L + +++ L EA + ++D
Sbjct: 1080 EEVLRAHEEQLKEAQAVP---ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGA-- 1134
Query: 286 FQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQE 345
QE+G + + + E V + R+ V L L ++ Q +++ ++L +E
Sbjct: 1135 -QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRE 1192
Query: 346 APGTNGSLVLATPGAGARPEPDSLQAR-LGQLQRNLSELHMTTARREEELQYTLEDMRAT 404
+ G+ + AR + +QA L Q +L A EE
Sbjct: 1193 SADPLGAWL-----QDARRRQEQIQAMPLADSQAVREQLRQEQALLEE------------ 1235
Query: 405 LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV 464
+ RH ++++E + + + I E Q+ V + A E V K ++ E V
Sbjct: 1236 IERHGEKVEECQRFAKQYINAIKDYELQL----VTYKAQLE-PVASPAKKPKVQSGSESV 1290
Query: 465 ERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDE 524
++ ++L L + IK++ + R +EE + ++
Sbjct: 1291 IQEYVDLRTHYSELTTLTSQYIKFISE-------------------TLRRMEEEERLAEQ 1331
Query: 525 RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAE 584
+R + L ++ A++ +AH +A L+ ++Q +EV + AA +
Sbjct: 1332 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVD 1388
Query: 585 ARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDA 644
A+ + R + L + + EA + A + E S E+IRV
Sbjct: 1389 AQQQKRSIQEELQQLRQSS---EAEIQAKARQAEAAERSRLR------IEEEIRVVRLQL 1439
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAE------HLEPSHDAGREEAATTALAG-- 696
+ +++ EL A E+A R A+ + ++ R+ A LA
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1499
Query: 697 -----LARELQSLSNDVKNVG-RCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRL 750
ARE Q ++ + + EAE A + + + AL QRS E +
Sbjct: 1500 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA-RQVQVALETAQRSAEAELQS 1558
Query: 751 FHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ F +E ++ + + + ++ Q+ EA R R++ E E
Sbjct: 1559 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1608
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 63.5 bits (153), Expect = 9e-10
Identities = 132/560 (23%), Positives = 224/560 (40%), Gaps = 90/560 (16%)
Query: 267 EANRQAI-SRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRS 325
E QA+ +R +++ + QE + +VQ+ +QR Q ++ R+ A+
Sbjct: 1458 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1517
Query: 326 ISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHM 385
LQA + +L+ A+EA +R L + +
Sbjct: 1518 QRALQALEELRLQ----AEEA------------------------------ERRLRQAEV 1543
Query: 386 TTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRE 445
AR ++Q LE T R + EL S+ ++ +++ER ++E V LRE
Sbjct: 1544 ERAR---QVQVALE----TAQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1594
Query: 446 LRVILMEKSLIMEENKEEVERQL----LELNLTLQ-HLQGGHADLIKYVKDCNC--QKLY 498
++ E +EE ER+L L+ N L+ LQ K + QK
Sbjct: 1595 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1654
Query: 499 LDLDVIREG--QRDATRALEETQVSLDERRQL-DGSSLQALQNAVDAVSLAVDAHKAEGE 555
+ + R G + A R E + L+++RQL +G++ Q L A + E
Sbjct: 1655 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL------------AAEQELI 1702
Query: 556 RARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAA-LF 614
R RA T + Q Q L++E+ L+ AA A + ++L + A + + E +LA+
Sbjct: 1703 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM---EVLLASKAR 1759
Query: 615 GEEVLEEMSEQTPGPLPLSYEQIRVALQDAA--SGLQEQALGWDELAARVTALEQASEPP 672
EE SE++ L + R ++AA L E+A +LA A ++A
Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1819
Query: 673 RPAEHLEPSHDAGR----EEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
AE L +A R E A L+ L+ D R E +A A +
Sbjct: 1820 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1879
Query: 729 SLHGLHNA-----------LFATQRSLEQHQRLFHSLFGNFQ--GLMEANVSLDLGKLQT 775
L L A + T R Q + +L +F+ +A + L+LG++++
Sbjct: 1880 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1939
Query: 776 ML-SRKGKKQQKDLEAPRKR 794
K+Q +LEA R+R
Sbjct: 1940 NAEDTLRSKEQAELEAARQR 1959
Score = 59.7 bits (143), Expect = 1e-08
Identities = 129/591 (21%), Positives = 216/591 (36%), Gaps = 77/591 (13%)
Query: 265 DVEANRQ---AISRVQDSAVA-----RADFQELGAKFEAKVQENTQRVGQLRQDVEDRLH 316
+VE RQ A+ Q SA A RA F E A+ E +QE V QLR++ E R
Sbjct: 1542 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1601
Query: 317 AQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQL 376
Q R+ E + +++ + ++A + A A E +A
Sbjct: 1602 -QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1660
Query: 377 QRNLSELHMTTARR--EEELQYTLEDMRATLTRHV---DEIKELYSESDETFDQISKVER 431
+R +E R E+EL+ + T + + E+ L +E+++ Q +E
Sbjct: 1661 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1720
Query: 432 QVEELQVNHTAL---------------RELRVILMEKSLIMEENK--EEVERQLLELNL- 473
++ LQ A E+ V+L K+ EE++ E +Q LE
Sbjct: 1721 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1780
Query: 474 TLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSL 533
+ L A L ++ Q+ + D R+ + +A R L E ++ E +L +
Sbjct: 1781 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEA- 1838
Query: 534 QALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLH 593
+A+ +AE ER R Q + L+++ KA E ++R+
Sbjct: 1839 ----------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1888
Query: 594 SA----FAALLEDALRHEAVLAALFGEEVLE-----EMSEQTPGPLPLSYEQIRVALQDA 644
+ L+ED LR + EE+L E + L L +IR +D
Sbjct: 1889 DSELERQKGLVEDTLRQRRQVE----EEILALKASFEKAAAGKAELELELGRIRSNAEDT 1944
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSL 704
++ L E A + + R AE A EEAA A L E++ L
Sbjct: 1945 LRSKEQAEL---EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERL 2000
Query: 705 SNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFA---------------TQRSLEQHQR 749
V+ R E A L + L A Q++L+Q Q
Sbjct: 2001 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060
Query: 750 LFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ L G + A + ++Q ++Q + EA R + E +
Sbjct: 2061 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQ 2110
Score = 53.5 bits (127), Expect = 9e-07
Identities = 145/632 (22%), Positives = 233/632 (36%), Gaps = 117/632 (18%)
Query: 257 QAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQL-RQDVEDRL 315
+A+R L L E Q S Q A + + E A+ K +E R +L Q++E +
Sbjct: 1626 EALR-LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684
Query: 316 HAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLV-LATPGAGARPEPDSLQARLG 374
T + ++ Q + + + Q+ L L A A + L+A L
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744
Query: 375 QLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSES--------------- 419
+++ + L + AR EEE + T E + L +EL E+
Sbjct: 1745 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1804
Query: 420 ---DETFDQISKVERQV-EELQVNHTALR---ELRVILMEKSLIME-------------- 458
++ Q ++ ER + E+L A R E + L EK E
Sbjct: 1805 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1864
Query: 459 -------ENKEEVERQLLEL----NLTLQHLQGGHADLIKYVKDCNCQKLYL-------- 499
++K ++E +L +L + L+ +G D ++ + + L L
Sbjct: 1865 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1924
Query: 500 --------DLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHK 551
+L IR D R+ E+ ++ +RQL + + A + V ++
Sbjct: 1925 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL---A 1981
Query: 552 AEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLA 611
AE E AR Q +A +EV LKA EAR + A L+ L EA
Sbjct: 1982 AEEEAAR--------QRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQEAAQK 2031
Query: 612 ALFGEEVLEEMS-EQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELA--ARVTALEQA 668
L EE + +Q L + +Q + L D G E A E A ARV A +A
Sbjct: 2032 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVL-DQLRGEAEAARRAAEEAEEARVQAEREA 2090
Query: 669 SEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
++ R E E + E+A A A A E + + E EA A + A
Sbjct: 2091 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAE---------KLRKEAEQEAARRAQAEQA 2141
Query: 729 SLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDL 788
+L A +E+H++ F +A V +L L+ L QK+L
Sbjct: 2142 ALRQKQ----AADAEMEKHKK-----FAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNL 2190
Query: 789 -------------EAPRKRDKKEAEPLVDIRV 807
EA R+R + E E L +RV
Sbjct: 2191 LDEELQRLKAEATEAARQRSQVE-EELFSVRV 2221
Score = 47.4 bits (111), Expect = 6e-05
Identities = 103/542 (19%), Positives = 198/542 (36%), Gaps = 39/542 (7%)
Query: 267 EANRQAISRVQDSAVARADFQELGAKFEAKVQENT-QRVGQLRQDVEDRLHAQHFTLHRS 325
E+ RQ + Q++A R +E F + +E Q+ Q Q V D+L + R+
Sbjct: 2017 ESARQ-LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2075
Query: 326 ISELQ-ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELH 384
E + A V + + ++ A A AR + + +L + E
Sbjct: 2076 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK------EAE 2129
Query: 385 MTTARREEELQYTLEDMRAT---LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHT 441
ARR + Q L +A + +H ++ + + +++ + Q+EE
Sbjct: 2130 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2189
Query: 442 ALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHL-------QGGHADLIKYVKDCNC 494
L E L ++ + +VE +L + + ++ L + + LI KD
Sbjct: 2190 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2249
Query: 495 QKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEG 554
+ L + + +++ +A R Q + R+ + Q A + + A + E
Sbjct: 2250 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EA 2308
Query: 555 ERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALF 614
R +A L+ Q + ++ L+ + ++ + F LE + + ++A
Sbjct: 2309 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2368
Query: 615 GEEVLE--EMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPP 672
L EMS + ++ R ++ L L E V LE
Sbjct: 2369 ERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE------ 2421
Query: 673 RPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHG 732
+ + HDA E A+A L RE + L + K + E L
Sbjct: 2422 --IQRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476
Query: 733 LHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPR 792
L + + + SL Q +R + L + V+ K Q L + ++QQ+ +E R
Sbjct: 2477 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQ-QLREEQQRQQQQMEQER 2531
Query: 793 KR 794
+R
Sbjct: 2532 QR 2533
Score = 40.4 bits (93), Expect = 0.008
Identities = 69/341 (20%), Positives = 144/341 (42%), Gaps = 32/341 (9%)
Query: 270 RQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISEL 329
++ + VQ++ +A+ + L + E QE +R+ + ++ + +L + R+ L
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRT---L 2354
Query: 330 QADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTAR 389
+A+ +L+ +A+ V A AR E D+ + R Q + +LH T
Sbjct: 2355 EAERQRQLEMSAEAERLK----LRVAEMSRAQARAEEDAQRFRK-QAEEIGEKLHRTELA 2409
Query: 390 REEE--LQYTLEDMRATLTRHVDEIKELYSESDETFDQISK----VERQVEELQV--NHT 441
+E+ L TLE R + ++E +E + +++ + ++ + EE+Q
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2469
Query: 442 ALRELRVI----------LMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKD 491
L+E + + L+++ +E+ K ++E+ + Q L+ + ++
Sbjct: 2470 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 492 CNCQKLYLDLDVIREGQRDAT----RALEETQVSLDERRQLDGSSLQALQNAVDAVSLAV 547
Q+L ++ R Q +A R EE Q +RRQ + + Q + + L
Sbjct: 2530 -ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2588
Query: 548 DAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE 588
+ H+A + T+ + + L + AL AAEA E
Sbjct: 2589 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2629
Score = 39.3 bits (90), Expect = 0.018
Identities = 111/590 (18%), Positives = 218/590 (36%), Gaps = 76/590 (12%)
Query: 226 EQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARAD 285
E+VL H + + P + L + +++ L EA + ++D
Sbjct: 1088 EEVLRAHEEQLKEAQAVP---ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGA-- 1142
Query: 286 FQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQE 345
QE+G + + + E V + R+ V L L ++ Q +++ ++L +E
Sbjct: 1143 -QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRE 1200
Query: 346 APGTNGSLVLATPGAGARPEPDSLQAR-LGQLQRNLSELHMTTARREEELQYTLEDMRAT 404
+ G+ + AR + +QA L Q +L A EE
Sbjct: 1201 SADPLGAWL-----QDARRRQEQIQAMPLADSQAVREQLRQEQALLEE------------ 1243
Query: 405 LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV 464
+ RH ++++E + + + I E Q+ V + A E V K ++ E V
Sbjct: 1244 IERHGEKVEECQRFAKQYINAIKDYELQL----VTYKAQLE-PVASPAKKPKVQSGSESV 1298
Query: 465 ERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDE 524
++ ++L L + IK++ + R +EE + ++
Sbjct: 1299 IQEYVDLRTHYSELTTLTSQYIKFISE-------------------TLRRMEEEERLAEQ 1339
Query: 525 RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAE 584
+R + L ++ A++ +AH +A L+ ++Q +EV + AA +
Sbjct: 1340 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVD 1396
Query: 585 ARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDA 644
A+ + R + L + + EA + A + E S E+IRV
Sbjct: 1397 AQQQKRSIQEELQQLRQSS---EAEIQAKARQAEAAERSRLR------IEEEIRVVRLQL 1447
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAE------HLEPSHDAGREEAATTALAG-- 696
+ +++ EL A E+A R A+ + ++ R+ A LA
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1507
Query: 697 -----LARELQSLSNDVKNVG-RCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRL 750
ARE Q ++ + + EAE A + + + AL QRS E +
Sbjct: 1508 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA-RQVQVALETAQRSAEAELQS 1566
Query: 751 FHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ F +E ++ + + + ++ Q+ EA R R++ E E
Sbjct: 1567 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1616
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 63.5 bits (153), Expect = 9e-10
Identities = 132/560 (23%), Positives = 224/560 (40%), Gaps = 90/560 (16%)
Query: 267 EANRQAI-SRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRS 325
E QA+ +R +++ + QE + +VQ+ +QR Q ++ R+ A+
Sbjct: 1499 EGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK 1558
Query: 326 ISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHM 385
LQA + +L+ A+EA +R L + +
Sbjct: 1559 QRALQALEELRLQ----AEEA------------------------------ERRLRQAEV 1584
Query: 386 TTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRE 445
AR ++Q LE T R + EL S+ ++ +++ER ++E V LRE
Sbjct: 1585 ERAR---QVQVALE----TAQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1635
Query: 446 LRVILMEKSLIMEENKEEVERQL----LELNLTLQ-HLQGGHADLIKYVKDCNC--QKLY 498
++ E +EE ER+L L+ N L+ LQ K + QK
Sbjct: 1636 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1695
Query: 499 LDLDVIREG--QRDATRALEETQVSLDERRQL-DGSSLQALQNAVDAVSLAVDAHKAEGE 555
+ + R G + A R E + L+++RQL +G++ Q L A + E
Sbjct: 1696 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL------------AAEQELI 1743
Query: 556 RARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAA-LF 614
R RA T + Q Q L++E+ L+ AA A + ++L + A + + E +LA+
Sbjct: 1744 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM---EVLLASKAR 1800
Query: 615 GEEVLEEMSEQTPGPLPLSYEQIRVALQDAA--SGLQEQALGWDELAARVTALEQASEPP 672
EE SE++ L + R ++AA L E+A +LA A ++A
Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1860
Query: 673 RPAEHLEPSHDAGR----EEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
AE L +A R E A L+ L+ D R E +A A +
Sbjct: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1920
Query: 729 SLHGLHNA-----------LFATQRSLEQHQRLFHSLFGNFQ--GLMEANVSLDLGKLQT 775
L L A + T R Q + +L +F+ +A + L+LG++++
Sbjct: 1921 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1980
Query: 776 ML-SRKGKKQQKDLEAPRKR 794
K+Q +LEA R+R
Sbjct: 1981 NAEDTLRSKEQAELEAARQR 2000
Score = 59.7 bits (143), Expect = 1e-08
Identities = 129/591 (21%), Positives = 216/591 (36%), Gaps = 77/591 (13%)
Query: 265 DVEANRQ---AISRVQDSAVA-----RADFQELGAKFEAKVQENTQRVGQLRQDVEDRLH 316
+VE RQ A+ Q SA A RA F E A+ E +QE V QLR++ E R
Sbjct: 1583 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1642
Query: 317 AQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQL 376
Q R+ E + +++ + ++A + A A E +A
Sbjct: 1643 -QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR 1701
Query: 377 QRNLSELHMTTARR--EEELQYTLEDMRATLTRHV---DEIKELYSESDETFDQISKVER 431
+R +E R E+EL+ + T + + E+ L +E+++ Q +E
Sbjct: 1702 RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE 1761
Query: 432 QVEELQVNHTAL---------------RELRVILMEKSLIMEENK--EEVERQLLELNL- 473
++ LQ A E+ V+L K+ EE++ E +Q LE
Sbjct: 1762 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1821
Query: 474 TLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSL 533
+ L A L ++ Q+ + D R+ + +A R L E ++ E +L +
Sbjct: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIGEATRLKTEA- 1879
Query: 534 QALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLH 593
+A+ +AE ER R Q + L+++ KA E ++R+
Sbjct: 1880 ----------EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1929
Query: 594 SA----FAALLEDALRHEAVLAALFGEEVLE-----EMSEQTPGPLPLSYEQIRVALQDA 644
+ L+ED LR + EE+L E + L L +IR +D
Sbjct: 1930 DSELERQKGLVEDTLRQRRQVE----EEILALKASFEKAAAGKAELELELGRIRSNAEDT 1985
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSL 704
++ L E A + + R AE A EEAA A L E++ L
Sbjct: 1986 LRSKEQAEL---EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-EEVERL 2041
Query: 705 SNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFA---------------TQRSLEQHQR 749
V+ R E A L + L A Q++L+Q Q
Sbjct: 2042 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101
Query: 750 LFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ L G + A + ++Q ++Q + EA R + E +
Sbjct: 2102 VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE-EAERLKQSAEEQ 2151
Score = 53.5 bits (127), Expect = 9e-07
Identities = 145/632 (22%), Positives = 233/632 (36%), Gaps = 117/632 (18%)
Query: 257 QAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQL-RQDVEDRL 315
+A+R L L E Q S Q A + + E A+ K +E R +L Q++E +
Sbjct: 1667 EALR-LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725
Query: 316 HAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLV-LATPGAGARPEPDSLQARLG 374
T + ++ Q + + + Q+ L L A A + L+A L
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785
Query: 375 QLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSES--------------- 419
+++ + L + AR EEE + T E + L +EL E+
Sbjct: 1786 KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1845
Query: 420 ---DETFDQISKVERQV-EELQVNHTALR---ELRVILMEKSLIME-------------- 458
++ Q ++ ER + E+L A R E + L EK E
Sbjct: 1846 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR 1905
Query: 459 -------ENKEEVERQLLEL----NLTLQHLQGGHADLIKYVKDCNCQKLYL-------- 499
++K ++E +L +L + L+ +G D ++ + + L L
Sbjct: 1906 RLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1965
Query: 500 --------DLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHK 551
+L IR D R+ E+ ++ +RQL + + A + V ++
Sbjct: 1966 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSL---A 2022
Query: 552 AEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLA 611
AE E AR Q +A +EV LKA EAR + A L+ L EA
Sbjct: 2023 AEEEAAR--------QRKAALEEVERLKAKVEEARRLRERAEQESARQLQ--LAQEAAQK 2072
Query: 612 ALFGEEVLEEMS-EQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELA--ARVTALEQA 668
L EE + +Q L + +Q + L D G E A E A ARV A +A
Sbjct: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVL-DQLRGEAEAARRAAEEAEEARVQAEREA 2131
Query: 669 SEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNA 728
++ R E E + E+A A A A E + + E EA A + A
Sbjct: 2132 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAE---------KLRKEAEQEAARRAQAEQA 2182
Query: 729 SLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDL 788
+L A +E+H++ F +A V +L L+ L QK+L
Sbjct: 2183 ALRQKQ----AADAEMEKHKK-----FAEQTLRQKAQVEQELTTLRLQLEE--TDHQKNL 2231
Query: 789 -------------EAPRKRDKKEAEPLVDIRV 807
EA R+R + E E L +RV
Sbjct: 2232 LDEELQRLKAEATEAARQRSQVE-EELFSVRV 2262
Score = 47.4 bits (111), Expect = 6e-05
Identities = 103/542 (19%), Positives = 198/542 (36%), Gaps = 39/542 (7%)
Query: 267 EANRQAISRVQDSAVARADFQELGAKFEAKVQENT-QRVGQLRQDVEDRLHAQHFTLHRS 325
E+ RQ + Q++A R +E F + +E Q+ Q Q V D+L + R+
Sbjct: 2058 ESARQ-LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2116
Query: 326 ISELQ-ADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELH 384
E + A V + + ++ A A AR + + +L + E
Sbjct: 2117 AEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK------EAE 2170
Query: 385 MTTARREEELQYTLEDMRAT---LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHT 441
ARR + Q L +A + +H ++ + + +++ + Q+EE
Sbjct: 2171 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2230
Query: 442 ALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHL-------QGGHADLIKYVKDCNC 494
L E L ++ + +VE +L + + ++ L + + LI KD
Sbjct: 2231 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2290
Query: 495 QKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEG 554
+ L + + +++ +A R Q + R+ + Q A + + A + E
Sbjct: 2291 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ-EA 2349
Query: 555 ERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALF 614
R +A L+ Q + ++ L+ + ++ + F LE + + ++A
Sbjct: 2350 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2409
Query: 615 GEEVLE--EMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPP 672
L EMS + ++ R ++ L L E V LE
Sbjct: 2410 ERLKLRVAEMS-RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLE------ 2462
Query: 673 RPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHG 732
+ + HDA E A+A L RE + L + K + E L
Sbjct: 2463 --IQRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 733 LHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPR 792
L + + + SL Q +R + L + V+ K Q L + ++QQ+ +E R
Sbjct: 2518 LQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVA----KAQ-QLREEQQRQQQQMEQER 2572
Query: 793 KR 794
+R
Sbjct: 2573 QR 2574
Score = 40.4 bits (93), Expect = 0.008
Identities = 69/341 (20%), Positives = 144/341 (42%), Gaps = 32/341 (9%)
Query: 270 RQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISEL 329
++ + VQ++ +A+ + L + E QE +R+ + ++ + +L + R+ L
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQKEL-AQEQARRLQEDKEQMAQQLAEETQGFQRT---L 2395
Query: 330 QADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTAR 389
+A+ +L+ +A+ V A AR E D+ + R Q + +LH T
Sbjct: 2396 EAERQRQLEMSAEAERLK----LRVAEMSRAQARAEEDAQRFRK-QAEEIGEKLHRTELA 2450
Query: 390 REEE--LQYTLEDMRATLTRHVDEIKELYSESDETFDQISK----VERQVEELQV--NHT 441
+E+ L TLE R + ++E +E + +++ + ++ + EE+Q
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2510
Query: 442 ALRELRVI----------LMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKD 491
L+E + + L+++ +E+ K ++E+ + Q L+ + ++
Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 492 CNCQKLYLDLDVIREGQRDAT----RALEETQVSLDERRQLDGSSLQALQNAVDAVSLAV 547
Q+L ++ R Q +A R EE Q +RRQ + + Q + + L
Sbjct: 2571 -ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629
Query: 548 DAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHE 588
+ H+A + T+ + + L + AL AAEA E
Sbjct: 2630 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2670
Score = 39.3 bits (90), Expect = 0.018
Identities = 111/590 (18%), Positives = 218/590 (36%), Gaps = 76/590 (12%)
Query: 226 EQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARAD 285
E+VL H + + P + L + +++ L EA + ++D
Sbjct: 1129 EEVLRAHEEQLKEAQAVP---ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGA-- 1183
Query: 286 FQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQE 345
QE+G + + + E V + R+ V L L ++ Q +++ ++L +E
Sbjct: 1184 -QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT-DVRQRELEQLGRQLRYYRE 1241
Query: 346 APGTNGSLVLATPGAGARPEPDSLQAR-LGQLQRNLSELHMTTARREEELQYTLEDMRAT 404
+ G+ + AR + +QA L Q +L A EE
Sbjct: 1242 SADPLGAWL-----QDARRRQEQIQAMPLADSQAVREQLRQEQALLEE------------ 1284
Query: 405 LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV 464
+ RH ++++E + + + I E Q+ V + A E V K ++ E V
Sbjct: 1285 IERHGEKVEECQRFAKQYINAIKDYELQL----VTYKAQLE-PVASPAKKPKVQSGSESV 1339
Query: 465 ERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDE 524
++ ++L L + IK++ + R +EE + ++
Sbjct: 1340 IQEYVDLRTHYSELTTLTSQYIKFISE-------------------TLRRMEEEERLAEQ 1380
Query: 525 RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAE 584
+R + L ++ A++ +AH +A L+ ++Q +EV + AA +
Sbjct: 1381 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ---EEVVRREEAAVD 1437
Query: 585 ARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDA 644
A+ + R + L + + EA + A + E S E+IRV
Sbjct: 1438 AQQQKRSIQEELQQLRQSS---EAEIQAKARQAEAAERSRLR------IEEEIRVVRLQL 1488
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAE------HLEPSHDAGREEAATTALAG-- 696
+ +++ EL A E+A R A+ + ++ R+ A LA
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRV 1548
Query: 697 -----LARELQSLSNDVKNVG-RCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRL 750
ARE Q ++ + + EAE A + + + AL QRS E +
Sbjct: 1549 KAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA-RQVQVALETAQRSAEAELQS 1607
Query: 751 FHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
+ F +E ++ + + + ++ Q+ EA R R++ E E
Sbjct: 1608 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1657
>gi|45433501 elastin microfibril interfacer 3 [Homo sapiens]
Length = 766
Score = 63.5 bits (153), Expect = 9e-10
Identities = 151/703 (21%), Positives = 247/703 (35%), Gaps = 126/703 (17%)
Query: 22 AQASSTSLSDLQSSRTPGVWKAEAEDTGKDPVGRNW-----CPYPMSKLVTLLALCKTEK 76
AQA T L L PG + TG P R C Y + + VT + E
Sbjct: 20 AQARGTPL--LARPAPPGASRYSLYTTGWRPRLRPGPHKALCAYVVHRNVTCILQEGAES 77
Query: 77 FLIHSQQPCPQGAPDCQKVKVMYRMAHKPVYQVKQKVLTSLAWRCCPGYTGPNCEHH--- 133
++ + C G P C V YR +P Y+V K +T LAWRCCPG+TG C H
Sbjct: 78 YVKAEYRQCRWG-PKCPGT-VTYRTVLRPKYKVGYKTVTDLAWRCCPGFTGKRCPEHLTD 135
Query: 134 ----DSMAIPEPADPGDSHQEPQDGPVSFK-----------PGHLAAVINEVEVQQEQQE 178
PEP P +P P S+ PG + +E ++
Sbjct: 136 HGAASPQLEPEPQIP-SGQLDPGPRPPSYSRAAPSPHGRKGPGLFGERLERLEGDVQRLA 194
Query: 179 HLLGDLQNDV--HRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTF 236
G L V H + + G +A + V+ G P L P +D
Sbjct: 195 QTYGTLSGLVASHEDPNRMTGGPRAPAVPVGFGVIPEGLVG---PGDRARGPLTPPLDEI 251
Query: 237 LQVHFSPIWRSFN--QSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQE------ 288
L S + N Q+ L + L+L EA+ Q + S + E
Sbjct: 252 L----SKVTEVSNTLQTKVQLLDKVHGLALGHEAHLQRLREAPPSPLTSLALLEEYVDRR 307
Query: 289 -------LGAKFEAKVQ----ENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKL 337
L FE K+Q E RV ++R+ E+ A LH+S+ + + +L
Sbjct: 308 LHRLWGSLLDGFEQKLQGVQSECDLRVQEVRRQCEEGQAASR-RLHQSLDGRELALRQEL 366
Query: 338 KRLHKAQEAPGTNG--------SLVLAT-----------------PGAGARPEPDSLQAR 372
+L + +G +L+ A PGA A E L A
Sbjct: 367 SQLGSQLQGLSVSGRGSCCGQLALINARMDGLERALQAVTETQRGPGAPAGDELTRLSAA 426
Query: 373 LGQ-----LQRNLSELHMTTARRE--------------------EELQYTLEDMRATLTR 407
+ + L L L+ T EE +LE+ ATL
Sbjct: 427 MLEGGVDGLLEGLETLNGTEGGARGCCLRLDMGGWGVGGFGTMLEERVQSLEERLATLAG 486
Query: 408 HV--DEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVI--LMEKSLIMEENKEE 463
+ D S +++ +E+++ L+ + T ++ L+ + + E
Sbjct: 487 ELSHDSASPGRSARPLVQTELAVLEQRLVSLETSCTPSTTSAILDSLVAEVKAWQSRSEA 546
Query: 464 VERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALE------- 516
+ RQ+ LQ L G A++ + + L ++ +++ +++L
Sbjct: 547 LLRQVASHAALLQQLNGTVAEVQGQLAEGTGSSLQGEITLLKVNLNSVSKSLTGLSDSVS 606
Query: 517 -------ETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQ 569
SLDER + + +QA+Q V + + A + R +L++ V
Sbjct: 607 QYSDAFLAANTSLDERERKVEAEVQAIQEQVSSQGSRLQAGHRQVLNLRGELEQLKAGVA 666
Query: 570 ALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAA 612
+ + + A + +H V A +E A R +LAA
Sbjct: 667 KVASGLSRCQDTAQKLQHTVGHFDQR-VAQVEGACRRLGLLAA 708
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 62.0 bits (149), Expect = 3e-09
Identities = 125/611 (20%), Positives = 244/611 (39%), Gaps = 112/611 (18%)
Query: 246 RSFNQSLHSLTQAIRNLSLDVEANRQAI------------SRVQDSAVARADFQELGAKF 293
+S + + L + +L+ D+E Q + R + + + D +++
Sbjct: 1633 KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSL 1692
Query: 294 EAKVQENTQRVGQLRQDVED--------RLHAQHFTLHRSISELQADVDTKLKRLHKAQE 345
+ +E T + +++ E+ R +H L + + + +V+ + + +H+ QE
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKL--ILRDKEKEVECQQEHIHELQE 1750
Query: 346 APGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATL 405
D L+ +L L R + E + ++RE+E+ + ++
Sbjct: 1751 LK-------------------DQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQE-- 1789
Query: 406 TRHVDEIKE--LYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEE 463
R E+KE L S+ DE +++ ++++E LQ + + EK+ +
Sbjct: 1790 AREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKA-------DA 1842
Query: 464 VERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLD 523
++ L + ++TL+ G ++D Q L+ ++ EG+R +ALEE L
Sbjct: 1843 LQGALEQAHMTLKERHG-------ELQDHKEQARRLEEELAVEGRR--VQALEEVLGDLR 1893
Query: 524 ERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQ--VQALDDEVGALKAA 581
+ +L ALQ A A + E E S L++Q ++ D E+ AL+A
Sbjct: 1894 AESREQEKALLALQQ-----QCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAE 1948
Query: 582 AAEARHEVRQLHSAFAALLEDALRHEAVLAA----LFGEEVLEEMSEQTPGPLPLSYE-- 635
+ +RH+ + AL E + A L L + L E + L S +
Sbjct: 1949 SQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDAC 2008
Query: 636 -----QIRVALQDAASGLQEQALGWDELAARV-TALEQASEPPRPAEHLEPSHDAGREEA 689
Q+ AL+ +Q+Q L + E ++ AL Q E E H RE+
Sbjct: 2009 QAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDE--------ELRHQQEREQL 2060
Query: 690 ATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQR 749
+LA R +++ + +N+G+ E E + GLH ++ Q +L Q ++
Sbjct: 2061 LEKSLA--QRVQENMIQEKQNLGQEREEE----------EIRGLHQSVRELQLTLAQKEQ 2108
Query: 750 LFHSL-----FGNFQGLMEAN-------VSLDLGKLQTMLSRKGKKQQKDLEAPRKRDKK 797
L N + L ++ SL L L+ L R+ ++ Q L R+ +
Sbjct: 2109 EILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIE 2168
Query: 798 EAEPLVDIRVT 808
E D+ ++
Sbjct: 2169 WREKAQDLALS 2179
Score = 59.7 bits (143), Expect = 1e-08
Identities = 137/528 (25%), Positives = 215/528 (40%), Gaps = 72/528 (13%)
Query: 321 TLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLA----TPGAGARPEPDSL------- 369
T R E+++ D L L KA+ +GSL+ T GA +R EP+
Sbjct: 186 TFRRHFLEMKSATDRDLMEL-KAEHVR-LSGSLLTCCLRLTVGAQSR-EPNGSGRMDGRE 242
Query: 370 QARLGQLQRNLSELHMTTARREEEL-----QYTLEDMRATLTRHVDEIKELYSES---DE 421
A+L L EL R +EL Q LE +A L V E+ L ++S +E
Sbjct: 243 PAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLE--KAELQDRVTELSALLTQSQKQNE 300
Query: 422 TFDQISKVERQ-VEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQG 480
++++ K R+ VE L+ NHT L E E SL +E++ Q + ++T ++
Sbjct: 301 DYEKMIKALRETVEILETNHTELME-----HEASLSRNAQEEKLSLQQVIKDITQVMVEE 355
Query: 481 GHADLIKYVKDCNCQKLYLDLDVIRE-GQRDATRALEETQVSLDERRQLDGSSLQALQNA 539
G D I L LD + + +DA +AL + L RRQ Q L
Sbjct: 356 G--DNIAQGSGHE-NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGC 412
Query: 540 VDAVSLAVDAHKAEGERARAATSRLR----------SQVQALDDEVGAL---KAAAAEAR 586
+AV+L H E +A RL+ Q L EV +L + +AR
Sbjct: 413 QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAR 472
Query: 587 HEVRQLHSAFAALLEDA--LRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDA 644
E+RQ L ++A LR V L G+ + EQ E++ +A+++
Sbjct: 473 EELRQ---QLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQ--------QEELHLAVRE- 520
Query: 645 ASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGR--EEAATTALAGLARELQ 702
LQE +G + + E SE E LE SH G + T A LAR Q
Sbjct: 521 RERLQEMLMGLEAKQS-----ESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 703 SLS--NDVKNVGRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQG 760
S++ + +N + A+ A A L+A L + L Q + S+ +
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 761 LMEANVSLDLGKLQTMLSRKGK-KQQKDLEAP-RKRDKKEAEPLVDIR 806
+A +L + + R+ ++ LEA +K ++ AE D+R
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLR 683
Score = 55.5 bits (132), Expect = 2e-07
Identities = 149/666 (22%), Positives = 256/666 (38%), Gaps = 128/666 (19%)
Query: 163 LAAVINEVEVQQEQQEHL---LGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHE 219
LA + E E ++ L L ++ D +A+ L GL A L +++ EA Q
Sbjct: 724 LARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKE-LLESSLFEAQQ---- 778
Query: 220 FPDRSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDS 279
S+ +V ++ +Q + Q+ + +R L L+++ R + +D+
Sbjct: 779 --QNSVIEVTKGQLEVQIQ--------TVTQAKEVIQGEVRCLKLELDTERSQAEQERDA 828
Query: 280 A---VARADFQELGAKFEAKVQENTQRVGQLRQ--DVEDRLHAQHF-----TLHRSISEL 329
A +A+A+ QE E + + + V QLR+ + E H Q +L R EL
Sbjct: 829 AARQLAQAE-QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMEL 887
Query: 330 QA---DVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHM- 385
+ + T+++ + +E T L E SL L Q Q+ L++
Sbjct: 888 EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ 947
Query: 386 -----------------TTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISK 428
TT + +LQ +++ +H D++ L ES
Sbjct: 948 LERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMD 1007
Query: 429 VERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKY 488
+++QVE+L+ A + ++E+ +E R+ E N + L+ A L
Sbjct: 1008 LQKQVEDLKSQLVAQDD-------SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLS 1060
Query: 489 VKDCNCQKLYL-DLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAV---DAVS 544
+ + + L L + D IR+ + A R ++ Q + E+++L + ++ L+ V +A
Sbjct: 1061 LMEKEQRLLVLQEADSIRQQELSALR--QDMQEAQGEQKELS-AQMELLRQEVKEKEADF 1117
Query: 545 LAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDAL 604
LA +A E A T Q L + A +A AA+ + +R S AL
Sbjct: 1118 LAQEAQLLEELEASHITE------QQLRASLWAQEAKAAQLQLRLRSTESQLEALA---- 1167
Query: 605 RHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTA 664
+EQ PG + Q + L S LQ QALG +
Sbjct: 1168 ------------------AEQQPG----NQAQAQAQLASLYSALQ-QALG--SVCESRPE 1202
Query: 665 LEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAA 724
L + LEP + R L L +LS AEA A A
Sbjct: 1203 LSGGGDSAPSVWGLEPDQNGARSLFKRGPL------LTALS-----------AEAVASA- 1244
Query: 725 SLNASLHGLHNALFATQRS----LEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRK 780
LH LH L+ TQ++ +Q Q+L L ++ V +L LQ LS+
Sbjct: 1245 -----LHKLHQDLWKTQQTRDVLRDQVQKLEERLTDT--EAEKSQVHTELQDLQRQLSQN 1297
Query: 781 GKKQQK 786
+++ K
Sbjct: 1298 QEEKSK 1303
Score = 50.1 bits (118), Expect = 1e-05
Identities = 122/602 (20%), Positives = 228/602 (37%), Gaps = 125/602 (20%)
Query: 249 NQSLHSLTQAIRNLSL---DVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVG 305
++++ SL +R L + + R+ + +++ A+ + + A EA+ Q + G
Sbjct: 1319 HETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ-AAVVEARAQASA--AG 1375
Query: 306 QLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPE 365
L +D+ T ++ +V+++ +R QE G L +A A
Sbjct: 1376 ILEEDLR--------TARSALKLKNEEVESERERAQALQE----QGELKVAQGKA----- 1418
Query: 366 PDSLQARLGQLQRNLSELHMTTARREEE---LQYTLEDMRATLTRHVDEIKELYSESDET 422
LQ NL+ L T A REEE L+ ++++ ++ L + +
Sbjct: 1419 ----------LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKR 1468
Query: 423 FDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV--------------ERQL 468
++ + Q++EL+ + L L + + E+ + +E++ E QL
Sbjct: 1469 NQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQL 1528
Query: 469 LEL---NLTLQHLQGGHADLIKYVKDCNCQKLYLD-----------LDVIREGQRDATR- 513
LEL + ++ +G DL K + C L L+ L EGQR+ R
Sbjct: 1529 LELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRV 1588
Query: 514 ALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDD 573
AL + L+ER Q LQA + + H E ++ L ++Q D
Sbjct: 1589 ALTHLTLDLEERSQ----ELQAQSSQI---------HDLESH-----STVLARELQERDQ 1630
Query: 574 EVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGE-EVLEEMSEQTPGPLPL 632
EV R ++ +L L +D R + L +VLE+ + L
Sbjct: 1631 EV-------KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE 1683
Query: 633 SYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATT 692
EQI+++L++ L Q R E+A E P++ G E
Sbjct: 1684 DLEQIKLSLRERGRELTTQ---------RQLMQERAEEGKGPSK-----AQRGSLEHMKL 1729
Query: 693 ALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFH 752
L +E++ + + + L L GLH + T L Q ++
Sbjct: 1730 ILRDKEKEVECQQEHIHELQELKD--------QLEQQLQGLHRKVGETSLLLSQREQEIV 1781
Query: 753 SLFGNFQ------GLMEANVSLDLGKLQTMLSRKG------KKQQKDLEAPRKRDKKEAE 800
L Q L E ++ L + Q L+++ +++Q+ + +R K++A+
Sbjct: 1782 VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKAD 1841
Query: 801 PL 802
L
Sbjct: 1842 AL 1843
Score = 45.1 bits (105), Expect = 3e-04
Identities = 124/569 (21%), Positives = 217/569 (38%), Gaps = 101/569 (17%)
Query: 276 VQDSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDT 335
VQD A QE + + + + LRQ ++ +L + TL +LQ +VD+
Sbjct: 402 VQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQ-KLTGERDTLAGQTVDLQGEVDS 460
Query: 336 KLKR---LHKAQEAPGTNGSLV------LATPGAGARPEPDSLQARLGQLQRNLSELHMT 386
K L KA+E ++ L + + DS Q GQ + ELH+
Sbjct: 461 LSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQ---GQKEEQQEELHLA 517
Query: 387 TARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALREL 446
R E LQ L + A + + E+ L E L+ +H
Sbjct: 518 V-RERERLQEMLMGLEAKQSESLSELITLR-----------------EALESSH------ 553
Query: 447 RVILMEKSLIMEENKE------EVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLD 500
+E L+ +E E E+ + EL+ + L+ ADL + L
Sbjct: 554 ----LEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALA 609
Query: 501 LDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGER---- 556
LD + L + + L+E Q S ++A + A +A L VD +AE R
Sbjct: 610 LDKV---------GLNQQLLQLEEENQSVCSRMEAAEQARNA--LQVDLAEAEKRREALW 658
Query: 557 ------------ARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDAL 604
A A + L++ ++ + +E ++ +E+RH+ + L ++A
Sbjct: 659 EKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
Query: 605 RHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTA 664
R E VLA E +E + L + + + QD A LQ + + L + +
Sbjct: 719 RQEEVLARAVQE---KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775
Query: 665 LEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAA 724
+Q + + + + T A + E++ L ++ E E A A
Sbjct: 776 AQQQNS----VIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAAR 831
Query: 725 SL-NASLHG---LHNALFATQRSLEQ------HQRLFHSLFGNFQGLMEANVSLDLGKLQ 774
L A G L A ++ + Q +R +H Q L +A SL+ K++
Sbjct: 832 QLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQ-----QELAKALESLEREKME 886
Query: 775 TMLSRKGKKQQKDLE---APRKRDKKEAE 800
L + K+QQ ++E A R+ ++ +AE
Sbjct: 887 --LEMRLKEQQTEMEAIQAQREEERTQAE 913
Score = 34.3 bits (77), Expect = 0.57
Identities = 70/336 (20%), Positives = 140/336 (41%), Gaps = 69/336 (20%)
Query: 265 DVEANRQAISRVQDSAVARADFQELGAKFEA-KVQENT----QRVGQLRQDVEDRLHAQH 319
DV+ +QA+++ + + + ++L K A +VQEN Q +GQ R++ E R
Sbjct: 2036 DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR----- 2090
Query: 320 FTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRN 379
LH+S+ ELQ + A+ E + L+ R Q + N
Sbjct: 2091 -GLHQSVRELQLTL----------------------------AQKEQEILELRETQQRNN 2121
Query: 380 LSEL---HMTTARREEELQYTLEDMRATLTRHVDEIKELYSESD----ETFDQISKVERQ 432
L L H T+ E+ L+ L+ + L R ++ ++ +++ E ++ +
Sbjct: 2122 LEALPHSHKTSPMEEQSLK--LDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALS 2179
Query: 433 VEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDC 492
+ + + + ++L+E+ + L L E E +R EL LT + L+
Sbjct: 2180 LAQTKASVSSLQEVAMFLQASVL---ERDSEQQRLQDELELTRRALEK------------ 2224
Query: 493 NCQKLYLD--LDVIREGQRDATRALEETQVS-LDERRQLDGSSLQALQNAVDAVSLAVDA 549
++L+ G R + ++ +VS ++ DG Q+ + ++ + AV
Sbjct: 2225 --ERLHSPGATSTAELGSR-GEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVAR 2281
Query: 550 HKAEGERARAATSRLRSQVQALDDEVGALKAAAAEA 585
+ + R + +LRS ++ ++ E LK A A
Sbjct: 2282 LEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRA 2317
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 61.6 bits (148), Expect = 3e-09
Identities = 136/642 (21%), Positives = 244/642 (38%), Gaps = 121/642 (18%)
Query: 185 QNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSLEQVLLPHVDTFLQVHFSPI 244
+N ++R+ + W+ NL + HE + + LP V+ +
Sbjct: 55 ENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGE------ 108
Query: 245 WRSFNQSLHSLTQAIRNLSLDVEANR---QAISRVQDSA--VARADFQELGAK------- 292
S L + Q I +++ E + QAI +++S V QEL +K
Sbjct: 109 -HSDAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESVQHVVMTAIQELMSKESPVSAG 167
Query: 293 ------FEAKVQENTQRVGQL---RQDVEDRLHA---QHFTLHRSISELQADVDTKLKRL 340
+ ++++ T+ + + ++++ R H Q L S L A+ ++RL
Sbjct: 168 NDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERL 227
Query: 341 HKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTAR---REEELQYT 397
+++ + P + A LQ +L QLQ L R EEL+
Sbjct: 228 NQSDS---------IEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKE 278
Query: 398 LEDMRAT---LTRHVDEIKELYSESD---ETFDQISKVERQVEELQVNHTALRELR---V 448
+ ++R LT DE + L E D + D++SK+E QVE + L +LR
Sbjct: 279 ISELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVK 338
Query: 449 ILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLI--------------------KY 488
+L EK+ + +N +E +L + N L+ ++ K
Sbjct: 339 LLEEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKR 398
Query: 489 VKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVD 548
+K+ L + D +R + +EE + + QL L L + + SLA
Sbjct: 399 LKE-KVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLA-- 455
Query: 549 AHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEA 608
A T +R ++ L E LK + +E L +LL+DA +
Sbjct: 456 --------AEIVTPEIREKLIRLQHENKMLKLNQEGSDNEKIAL---LQSLLDDANLRKN 504
Query: 609 VLAA---LFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTAL 665
L L + +LE S+ E+++ +LQD S ++ L +L + L
Sbjct: 505 ELETENRLVNQRLLEVQSQ---------VEELQKSLQDQGSKAEDSVLLKKKLEEHLEKL 555
Query: 666 EQASEPPRP----AEHLEP--SHDAGREEAATTALAGLARELQSLS-------NDVKNVG 712
+A+ + E LEP ++ + + E AL E++ + K+V
Sbjct: 556 HEANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVI 615
Query: 713 RCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFHSL 754
R + + GAA + A + L++ RLFHSL
Sbjct: 616 RTLDPKQNQGAAP----------EIQALKNQLQERDRLFHSL 647
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 61.2 bits (147), Expect = 4e-09
Identities = 120/550 (21%), Positives = 225/550 (40%), Gaps = 75/550 (13%)
Query: 246 RSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKF--EAKVQENTQR 303
+ + L +L Q +L L V+A + + ++ R D Q + AKF EAK++E T+R
Sbjct: 872 KELEEKLVTLVQEKNDLQLQVQAESENLLDAEE----RCD-QLIKAKFQLEAKIKEVTER 926
Query: 304 VGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGAR 363
+++ L A+ L SEL+ D+D L K ++ + V
Sbjct: 927 AED-EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV--------- 976
Query: 364 PEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETF 423
+L L L +++L +E Q L+D++A D++ L
Sbjct: 977 ---KNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQA----EEDKVNSLNKTK---- 1025
Query: 424 DQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHA 483
SK+E+QVE+L+ + ++LRV L E NK ++E L ++ L+
Sbjct: 1026 ---SKLEQQVEDLESSLEQEKKLRVDL-------ERNKRKLEGDLKLAQESILDLENDKQ 1075
Query: 484 DLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAV 543
L + +K + + L V E + +L + Q LQA ++
Sbjct: 1076 QLDERLKKKDFEYCQLQSKV-------------EDEQTLGLQFQKKIKELQARIEELEEE 1122
Query: 544 SLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDA 603
A A +A+ E+ R+ +R ++ +E G + + E + LE+A
Sbjct: 1123 IEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA 1182
Query: 604 -LRHEAVLAALFGE--EVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAA 660
L+HEA++AAL + + + E+ EQ + ++++ L+ S E L D+L+
Sbjct: 1183 TLQHEAMVAALRKKHADSVAELGEQID-----NLQRVKQKLEKEKS---EFKLEIDDLS- 1233
Query: 661 RVTALEQASEPPRPAEHL------EPSHDAGREEAATTALAGLARELQSLSNDVKNVGRC 714
+++E S+ E + + S G+ E +L+ L + L + + R
Sbjct: 1234 --SSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ 1291
Query: 715 CEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQ 774
E E + + L+ S +R LE+ + ++L L + DL + Q
Sbjct: 1292 LE-EKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNAL---AHALQSSRHDCDLLREQ 1347
Query: 775 TMLSRKGKKQ 784
++GK +
Sbjct: 1348 YEEEQEGKAE 1357
Score = 48.1 bits (113), Expect = 4e-05
Identities = 105/488 (21%), Positives = 185/488 (37%), Gaps = 53/488 (10%)
Query: 163 LAAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALP--GNLTAAVMEANQTGH-E 219
L A I E+E + E + + A L L + L G +T+ +E N+ E
Sbjct: 1112 LQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAE 1171
Query: 220 FPD--RSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQ 277
F R LE+ L H + + + + S+ L + I NL + +Q + + +
Sbjct: 1172 FLKLRRDLEEATLQH-----EAMVAALRKKHADSVAELGEQIDNL----QRVKQKLEKEK 1222
Query: 278 DSAVARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKL 337
D + +K + N +++ + +D ++ + RS+SEL T+
Sbjct: 1223 SEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELT----TQK 1278
Query: 338 KRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYT 397
RL EA + L E +S+ ++L + ++ ++ R+ EE
Sbjct: 1279 SRLQT--EAGELSRQL----------EEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA 1326
Query: 398 LEDMRATL--TRH-VDEIKELYSESDETFDQI----SKVERQVEELQVNHTA-------- 442
+ L +RH D ++E Y E E ++ SK +V + + +
Sbjct: 1327 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1386
Query: 443 LRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDL- 501
L E + L ++ EE E V + L T Q LQG DL+ V+ N LD
Sbjct: 1387 LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKK 1446
Query: 502 -----DVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGER 556
V+ E + + E + SL E R L + L L+NA + ++ K E +
Sbjct: 1447 QRNFDKVLAEWKTKCEESQAELEASLKESRSL-STELFKLKNAYEEALDQLETVKRENKN 1505
Query: 557 ARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGE 616
+ L Q+ + L+ + + E + A E AL HE
Sbjct: 1506 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEE-AEAALEHEEAKILRIQL 1564
Query: 617 EVLEEMSE 624
E+ + SE
Sbjct: 1565 ELTQVKSE 1572
Score = 32.0 bits (71), Expect = 2.8
Identities = 71/354 (20%), Positives = 150/354 (42%), Gaps = 45/354 (12%)
Query: 247 SFNQSLHSLTQAIRNLSLDVE-ANRQAIS-----RVQDSAVA--RADFQELGAKFEAKVQ 298
S ++ L + +L +DVE AN A + R D +A + +E A+ EA ++
Sbjct: 1414 SLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLK 1473
Query: 299 EN---TQRVGQLRQDVEDRLHA------QHFTLHRSISELQADVDTKLKRLHKAQEAPGT 349
E+ + + +L+ E+ L ++ L + I++L + K +H+ +++
Sbjct: 1474 ESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ 1533
Query: 350 ----NGSLVLATPGAGARPEPDSLQARLGQLQRNL----SELHMTTARREEELQYTLEDM 401
+ LA A A E + +A++ ++Q L SE+ A ++EE++ +
Sbjct: 1534 IELEKADIQLALEEAEAALEHE--EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNY 1591
Query: 402 RATLTRHVDEIKELYSESDETFDQISKVERQVE--ELQVNHT------ALRELRVI---L 450
+ T+ + +E K+E + E+Q++H L+ LR + L
Sbjct: 1592 QRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL 1651
Query: 451 MEKSLIMEE---NKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREG 507
+ L +++ +E+++ QL + LQ +L ++ + + +++
Sbjct: 1652 KDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSN 1711
Query: 508 QRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAAT 561
+R + L SL ++ + L LQ+ V+ S DA AE + +A T
Sbjct: 1712 ER--VQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASR--DARNAEEKAKKAIT 1761
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 61.2 bits (147), Expect = 4e-09
Identities = 90/360 (25%), Positives = 156/360 (43%), Gaps = 57/360 (15%)
Query: 371 ARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVE 430
AR+GQLQ L+E H + +LQ T E A + ++ EL + +++ +Q+S +
Sbjct: 282 ARVGQLQEALNERHSIINALKAKLQMT-EAALALSEQKAQDLGELLATAEQ--EQLSLSQ 338
Query: 431 RQVEELQV--NHTALRELRVI-----LMEKSLIMEENKEEVER----QLLELNLTLQHLQ 479
RQ +EL++ A RE +++ EK+L+++ +E+ER Q +L T Q +
Sbjct: 339 RQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMT 398
Query: 480 GGHADLIKY---------VKDCNCQKLYLDLDVIR-EGQRDATRALEETQVSLDERRQLD 529
A+L ++ C++ D + +R + TR LEE++ ++ ER Q
Sbjct: 399 SMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRL 458
Query: 530 GSSLQALQNAVDAVSLAV----------------DAHKAEGERARAATSRLRSQVQALDD 573
++ +L+ + V A A E +R +LR QA D+
Sbjct: 459 EAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDE 518
Query: 574 EVGAL---KAAAAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPL 630
GA K AEA+ V QL L + LR EE+ +E+S + +
Sbjct: 519 AQGACLQQKQVVAEAQTRVSQL-----GLQVEGLRRRL-------EELQQELSLKDQERV 566
Query: 631 PLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAA 690
++RV LQ+ LQ + + L + ALE+ + ++H E D E A+
Sbjct: 567 -AEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLK-VMASDHREALLDRESENAS 624
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 58.9 bits (141), Expect = 2e-08
Identities = 115/487 (23%), Positives = 184/487 (37%), Gaps = 78/487 (16%)
Query: 296 KVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVL 355
+V E QRV + + E L A L ++ +V+ ++ + E S+
Sbjct: 478 EVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQ--LRRSMQD 535
Query: 356 ATPG-AGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKE 414
AT A E + A + LQR L E T + Q ED+RAT + E
Sbjct: 536 ATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRME 595
Query: 415 LYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKE------------ 462
+E ++I ++R++E+ + + R++ V+ E EE KE
Sbjct: 596 KEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAG 655
Query: 463 ----------------------EVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLD 500
E+E Q L+L TLQ L+ + ++ + K+ +
Sbjct: 656 RHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLR-------QDCEEASKAKMVAE 708
Query: 501 LDVIREGQRDAT--RALEETQVSLDE-RRQLDG--SSLQALQNAVDAVSLAVDAHKAEGE 555
+ GQR A L ETQ DE RR++ G L+ + VD + + +
Sbjct: 709 AEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQ 768
Query: 556 RARAATSRLRSQVQALDDEVGALKAA--AAEARHEVRQ---------LHSAFAALLEDAL 604
R A +L + A +E G+L AA A EAR E Q + AL E+
Sbjct: 769 RLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGK 828
Query: 605 RHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTA 664
+ E + E + + ++T L E+I + A LQ Q + E A R A
Sbjct: 829 QREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVA 888
Query: 665 LEQ------ASEPPRPA----------EHLEPSHDAGREEAATTALAG--LARELQSLSN 706
Q ASE + + + L + A + E T L LA+ LQ L
Sbjct: 889 DAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQ 948
Query: 707 DVKNVGR 713
+ +N R
Sbjct: 949 EAENKKR 955
Score = 52.8 bits (125), Expect = 2e-06
Identities = 104/483 (21%), Positives = 190/483 (39%), Gaps = 45/483 (9%)
Query: 265 DVEANRQAIS-RVQDSAVARADFQELGAK---FEAKVQENTQRVGQLR---QDVEDRLHA 317
D E R+++ QD AV A+ Q++ A + +++E ++ G + Q ++ L A
Sbjct: 525 DTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRA 584
Query: 318 ---QHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLG 374
+ L E++ ++ K++ L + E A AG + + L+ L
Sbjct: 585 TKQELLQLRMEKEEMEEELGEKIEVLQRELEQ---------ARASAGDTRQVEVLKKELL 635
Query: 375 QLQRNLSELHMTTARREEELQYT---LEDMRATLTRHVDEIKELYSESDETFDQISKVER 431
+ Q L EL +E ++ LE A L D +EL ++ + + ++ +
Sbjct: 636 RTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ 695
Query: 432 QVEEL-------QVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQG---G 481
EE + T L + R + +E +E R++L L L+ +G G
Sbjct: 696 DCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDG 755
Query: 482 HADLIKYVKDCNCQKLYLDLDVIREG---QRDATRALEETQVSLDERRQLDGSSLQALQN 538
+ ++D Q+L + + E ++ +L + +L+ R + L L
Sbjct: 756 GEAVEARLRD-KLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQ 814
Query: 539 AVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAA 598
++ A++ + E R + L Q + LD V L + + +Q A
Sbjct: 815 EQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQA 874
Query: 599 LLED---ALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQI---RVALQDAASGLQEQA 652
LED R E A ++ E +E+T G L ++I R ALQ + +
Sbjct: 875 QLEDYKEKARREVADAQRQAKDWASE-AEKTSGGLSRLQDEIQRLRQALQASQAERDTAR 933
Query: 653 LGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQS--LSNDVKN 710
L + LA R+ LEQ +E + ++ G EE + L E + L D N
Sbjct: 934 LDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVN 993
Query: 711 VGR 713
GR
Sbjct: 994 RGR 996
Score = 50.8 bits (120), Expect = 6e-06
Identities = 111/510 (21%), Positives = 195/510 (38%), Gaps = 70/510 (13%)
Query: 321 TLHRSISELQADVDTKLKR-----LHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQ 375
T++ + E ++ +T ++R L K Q + A G G L ++ +
Sbjct: 317 TIYGILREGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQG------ELTRKVEE 370
Query: 376 LQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEE 435
LQR L E E + + LE + L R ++E E S E +ER+ E
Sbjct: 371 LQRKLDE--------EVKKRQKLEPSQVGLERQLEEKTEECSRLQEL------LERRKGE 416
Query: 436 LQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQ 495
Q ++ L+ ++ +L + E+ + +E Q++EL L+H+QG K+ +
Sbjct: 417 AQQSNKELQNMKRLLDQG----EDLRHGLETQVMELQNKLKHVQGPEP-----AKEVLLK 467
Query: 496 KLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGE 555
L +++ E R E+ ++ E L G+ + + + V ++ + E
Sbjct: 468 DLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTE 527
Query: 556 RARAAT-------SRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLED--ALRH 606
+ R + + L ++ Q + V L+ E E S F ED A +
Sbjct: 528 QLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQ 587
Query: 607 EAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDA--ASGLQEQALGWDELAARVTA 664
E + + EE+ EE+ E+ L EQ R + D L+++ L E + A
Sbjct: 588 ELLQLRMEKEEMEEELGEKIE-VLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQA 646
Query: 665 LEQASEP---------PRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCC 715
Q+ E + L D GRE L + LQ L D C
Sbjct: 647 ERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQN--LQLQKTLQQLRQD------CE 698
Query: 716 EAEAGAGAASLNASLHGLHNALFAT--QRSLEQHQRLFHSLFGNFQGLMEANVSLDLG-- 771
EA A A++ G A T + + E++ + G Q L E +D G
Sbjct: 699 EASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEA 758
Query: 772 ---KLQTMLSRKGKKQQKDLEAPRKRDKKE 798
+L+ L R ++Q+ EA ++E
Sbjct: 759 VEARLRDKLQRLEAEKQQLEEALNASQEEE 788
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 58.2 bits (139), Expect = 4e-08
Identities = 106/570 (18%), Positives = 227/570 (39%), Gaps = 69/570 (12%)
Query: 246 RSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVG 305
+ + + SL Q +L L V++ + + ++ + L EAKV+E T+R+
Sbjct: 875 KELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKIL---LEAKVKELTERLE 931
Query: 306 QLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPE 365
+ +++ L A+ L S L+ D+D L K ++ + V
Sbjct: 932 E-EEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKV----------- 979
Query: 366 PDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQ 425
+L + L+ N+S+L +E Q TL+D++ + V+ + ++ ++ ++ D
Sbjct: 980 -KNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDK-VNGLIKINAKLEQQTDD 1037
Query: 426 ISKVERQVEELQVN-HTALRELRVIL---MEKSLIMEENKEEVERQLLELNLTLQHLQGG 481
+ Q ++L+ + A R+L L E + +E +K+++E +L + L LQ
Sbjct: 1038 LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAK 1097
Query: 482 HADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVD 541
D + V QK +L E + A + ++++R L+ + ++
Sbjct: 1098 IDD--EQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLE 1155
Query: 542 AVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLE 601
S A A ++ A ++R ++ E H A AA L
Sbjct: 1156 EASGATSAQIEMNKKREAEFQKMRRDLE------------------EATLQHEATAATLR 1197
Query: 602 DALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAAR 661
+ +A A GE++ + ++ L ++++ + D AS ++ + +
Sbjct: 1198 ---KKQADSVAELGEQI--DNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERT 1252
Query: 662 VTALE-QASE-PPRPAEHLEPSHD---------------AGREEAATTALAGLARELQSL 704
+E Q SE + + + HD + R E + ++ L + Q+L
Sbjct: 1253 CRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQAL 1312
Query: 705 SNDVKNVGRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEA 764
+ ++ + R E E A NA H L ++ EQ++ + + L +A
Sbjct: 1313 TQQLEELKRQMEEETKA----KNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKA 1368
Query: 765 NVSLDLGKLQTMLSRKGKKQQKDLEAPRKR 794
N ++ + +T ++ ++LE +K+
Sbjct: 1369 N--SEVAQWRTKYETDAIQRTEELEEAKKK 1396
Score = 46.6 bits (109), Expect = 1e-04
Identities = 103/481 (21%), Positives = 189/481 (39%), Gaps = 73/481 (15%)
Query: 163 LAAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALP--GNLTAAVMEANQTGH-E 219
L A I E+E + E + L ++ +A L + + L T+A +E N+ E
Sbjct: 1115 LQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAE 1174
Query: 220 FPD--RSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQ 277
F R LE+ L H T + + S+ L + I NL + +Q + +
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLR-----KKQADSVAELGEQIDNL----QRVKQKLEK-- 1223
Query: 278 DSAVARADFQELGAKFEA--KVQENTQRVGQLRQDVEDRLHA---QHFTLHRSISELQAD 332
+ + + + ++ + EA K + N +R + +D + A Q L ++ +A
Sbjct: 1224 EKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKAR 1283
Query: 333 VDTKLKRL-HKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTARRE 391
+ T+ L H+ +E L + +L +L +L+R + E + +
Sbjct: 1284 LQTQNGELSHRVEEKESLISQLTKSK---------QALTQQLEELKRQMEE----ETKAK 1330
Query: 392 EELQYTLEDMRATLTRHVDEIKELYSESDETFDQI----SKVERQVEELQVNHTA----- 442
+ + L+ R D ++E Y E E ++ SK +V + + +
Sbjct: 1331 NAMAHALQSSR----HDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQR 1386
Query: 443 ---LRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYL 499
L E + L ++ EEN E + L T Q LQG DL++ ++ + L
Sbjct: 1387 TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446
Query: 500 DLDVIREGQRDATRALEETQVSLDERR------QLDGSSLQA----LQNAVDAVSLAVDA 549
D + QR+ + L E + LDE + Q + SL ++NA + V ++
Sbjct: 1447 D-----KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLET 1501
Query: 550 HKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLED---ALRH 606
+ E + + S L Q+ E G A + + V Q S LE+ +L H
Sbjct: 1502 LRRENKNLQEEISDLTEQIA----ETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEH 1557
Query: 607 E 607
E
Sbjct: 1558 E 1558
>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
Length = 1133
Score = 58.2 bits (139), Expect = 4e-08
Identities = 130/599 (21%), Positives = 237/599 (39%), Gaps = 97/599 (16%)
Query: 123 PGYTG-PNCEHHDSMAIP----------------EPADPGDSHQEPQDGPVSFKPGHLAA 165
PG +G P ++H + A+P EPA S Q+P + V +P +
Sbjct: 490 PGVSGSPVTQNHAASALPTGSPKRGTAPGDLSATEPATCFPSTQKPTEPSVPVQPLLPES 549
Query: 166 VINEVEVQQEQQEHLLG---DLQ-NDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFP 221
+ + E Q+ LL LQ + A+ L + +E + HE
Sbjct: 550 LARSLLPSTEYQKQLLAAQVQLQCSPAELQAELLHSQARLAELEAQVRKLELERAQHELL 609
Query: 222 DRSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAV 281
SL+Q ++ H S I + S + +R + ++ A + +S+ Q++
Sbjct: 610 LGSLQQQHQADLELIESAHRSRI-KVLETSYQQREERLRRENEELSA--RYLSQCQEAEQ 666
Query: 282 ARADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLH 341
ARA+ ++ +R+ + Q+ + + SI +++ D + +L+RL
Sbjct: 667 ARAEL----------TAQHQRRLAAIAQEKDQEMERLRELQRASILDMRRDHEEQLQRLK 716
Query: 342 --KAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRNLSELHMTTAR-REEELQYTL 398
K +E + + + + L +L + H+TT++ RE ++
Sbjct: 717 LLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQERELGIRQRD 776
Query: 399 EDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEK-SLIM 457
E +RA R + +++ E + I K+E ++ E + R++ E+ +
Sbjct: 777 EQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNE---------QSRLLEQERWRVTA 827
Query: 458 EENKEEVERQLLE--LNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRAL 515
E++K E ++ LE +T Q + A+L + A AL
Sbjct: 828 EQSKAESMQRALEEQRKVTAQQMAMERAELER-----------------------AKSAL 864
Query: 516 EETQVSL-----DERRQL--DGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQV 568
E Q S+ +ERR+L + + A Q L+ + + E ERA ++ +
Sbjct: 865 LEEQKSVMLKCGEERRRLAAEWAEFSAQQK------LSKERAEREAERALQVDTQREGTL 918
Query: 569 QALDDEVGALKAAAAEARHEVRQLHSAFAALLED----ALRHEAVLAALFGEEVLEEMSE 624
+L E LK A+E R E +QL + AAL ++ L E + A ++ E E
Sbjct: 919 ISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKERINATALRVKLRAEEVE 978
Query: 625 QTPGPLPLSYEQIRVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAE-HLEPSH 682
YE+ AL++A Q QA E AR+ A++Q E R E H+ H
Sbjct: 979 SMSKVASEKYEEGERALREAQ---QVQA----EQQARLQAVQQQQERLRKQEQHMHQEH 1030
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 57.4 bits (137), Expect = 6e-08
Identities = 135/683 (19%), Positives = 262/683 (38%), Gaps = 117/683 (17%)
Query: 163 LAAVINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPD 222
+A + E + QE + L DLQ + +V LT A ++ Q + +
Sbjct: 989 IAKLTKEKKALQEAHQQALDDLQAEEDKV------------NTLTKAKVKLEQQVDDL-E 1035
Query: 223 RSLEQVLLPHVDTFLQVHFSPIWRSFNQSLHSLTQAIRNLSLDVEANRQAISRVQ---DS 279
SLEQ + +++ R L ++I +L D + + + + ++
Sbjct: 1036 GSLEQ------EKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089
Query: 280 AVARA-DFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLK 338
AR D Q LG++ + K++E R+ +++E+ L A+ T + +L++D+ +L+
Sbjct: 1090 LNARIEDEQALGSQLQKKLKELQARI----EELEEELEAER-TARAKVEKLRSDLSRELE 1144
Query: 339 RLHKAQEAPGTNGSLVL-------------------------ATPGAGARPEPDSLQARL 373
+ + E G S+ + AT A + DS+ A L
Sbjct: 1145 EISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSV-AEL 1203
Query: 374 GQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQV 433
G+ NL + + + E + L+D+ + + + + L DQ+++ +
Sbjct: 1204 GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKA 1263
Query: 434 EELQVNHTALRELRVILMEKSLIME---ENKEEVERQLLELNLT-LQHLQGGHADLIKYV 489
EE Q + L R L ++ + + KE + QL LT Q L+ L + V
Sbjct: 1264 EETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEV 1323
Query: 490 KDCNC-----QKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGSSLQALQNAVDAVS 544
K N Q D D++RE EET+ + +R L ++ + Q +
Sbjct: 1324 KAKNALAHALQSARHDCDLLREQYE------EETEAKAELQRVLSKANSEVAQWRTKYET 1377
Query: 545 LAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAFAALLEDAL 604
A+ E A +L ++Q ++ V A+ A + +L + L+ D
Sbjct: 1378 DAIQ----RTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1433
Query: 605 RHEAVLAALFG-----EEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALGWDELA 659
R A AAL +++L E ++ YE+ + L+ + Q++A L+
Sbjct: 1434 RSNAAAAALDKKQRNFDKILAEWKQK--------YEESQSELESS----QKEA---RSLS 1478
Query: 660 ARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEA 719
+ L+ A E EHLE + L E+ L+ + + G+ E
Sbjct: 1479 TELFKLKNAYE--ESLEHLETFKRENK---------NLQEEISDLTEQLGSSGKTIH-EL 1526
Query: 720 GAGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSR 779
L A L +AL + SLE + L+ +++ + R
Sbjct: 1527 EKVRKQLEAEKMELQSALEEAEASLEHEEGKI------------LRAQLEFNQIKAEIER 1574
Query: 780 KGKKQQKDLEAPRKRDKKEAEPL 802
K ++ +++E ++ + + L
Sbjct: 1575 KLAEKDEEMEQAKRNHLRVVDSL 1597
Score = 57.4 bits (137), Expect = 6e-08
Identities = 108/495 (21%), Positives = 196/495 (39%), Gaps = 85/495 (17%)
Query: 247 SFNQSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQ 306
S ++ H L I +L +DVE + A + + + +F ++ A+++ K +E+ +
Sbjct: 1413 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK---QRNFDKILAEWKQKYEESQSELES 1469
Query: 307 LRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEP 366
+++ L + F L + E ++T + QE E
Sbjct: 1470 SQKEARS-LSTELFKLKNAYEESLEHLETFKRENKNLQE-------------------EI 1509
Query: 367 DSLQARLGQLQRNLSELHMTTARREEE---LQYTLEDMRATLTRHVDEIKELYSESDETF 423
L +LG + + EL + E E LQ LE+ A+L +I E F
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE----F 1565
Query: 424 DQI-SKVERQVEEL--QVNHTALRELRVI-LMEKSLIMEEN--------KEEVERQLLEL 471
+QI +++ER++ E ++ LRV+ ++ SL E K+++E L E+
Sbjct: 1566 NQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEM 1625
Query: 472 NLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGS 531
+ L H A+ K VK + Q L L++TQ+ LD+ + +
Sbjct: 1626 EIQLSHANRMAAEAQKQVK--SLQSL-----------------LKDTQIQLDDAVRANDD 1666
Query: 532 SLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQ 591
L+ + V + +AE E RA + + + E+ E V+
Sbjct: 1667 ----LKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQEL-------IETSERVQL 1715
Query: 592 LHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQ 651
LHS +L+ + +A L+ L E +EE ++ + E+ + A+ DAA +E
Sbjct: 1716 LHSQNTSLINQKKKMDADLSQLQTE--VEEAVQECRN----AEEKAKKAITDAAMMAEEL 1769
Query: 652 ALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNV 711
D A + + + +H +EA AL G ++LQ L V+ +
Sbjct: 1770 KKEQDTSAHLERMKKNMEQTIKDLQHR-------LDEAEQIALKGGKKQLQKLEARVREL 1822
Query: 712 GRCCEAEAGAGAASL 726
EAE A S+
Sbjct: 1823 ENELEAEQKRNAESV 1837
Score = 48.1 bits (113), Expect = 4e-05
Identities = 95/423 (22%), Positives = 172/423 (40%), Gaps = 62/423 (14%)
Query: 385 MTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALR 444
+ +A RE+E+ M+ TR + +++ + E +++ + ++ +LQ+ A +
Sbjct: 840 LKSAEREKEMA----SMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQ 895
Query: 445 ELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLI--KYVKDCNCQKLYLDLD 502
+ E+ + +NK ++E ++ E+N L+ + +A+L K + C +L D+D
Sbjct: 896 DNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDID 955
Query: 503 VIR------EGQRDAT----RALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKA 552
+ E ++ AT + L E LDE +ALQ +A A+D +A
Sbjct: 956 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ---EAHQQALDDLQA 1012
Query: 553 EGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVR-QLHSAFAALLED-ALRHEAVL 610
E ++ T Q +DD G+L E +VR L A L D L E+++
Sbjct: 1013 EEDKVNTLTKAKVKLEQQVDDLEGSL-----EQEKKVRMDLERAKRKLEGDLKLTQESIM 1067
Query: 611 AALFGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGLQEQALG------WDELAARVTA 664
++ L+E ++ L + ++D EQALG EL AR+
Sbjct: 1068 DLENDKQQLDERLKKKDFEL----NALNARIED------EQALGSQLQKKLKELQARIEE 1117
Query: 665 LEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAA 724
LE+ E R A + L+REL+ +S ++ G GA
Sbjct: 1118 LEEELEAERTA-----------RAKVEKLRSDLSRELEEISERLEEAG---------GAT 1157
Query: 725 SLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQ 784
S+ ++ A F R + L H A+ +LG+ L R +K
Sbjct: 1158 SVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1217
Query: 785 QKD 787
+K+
Sbjct: 1218 EKE 1220
Score = 41.6 bits (96), Expect = 0.004
Identities = 102/554 (18%), Positives = 218/554 (39%), Gaps = 96/554 (17%)
Query: 265 DVEANRQAISRVQDSAVA--RADFQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHF-- 320
+ +A Q + +S VA R ++ + +++E +++ Q Q+ E+ + A +
Sbjct: 1352 EAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKC 1411
Query: 321 -TLHRSISELQADVDTKLKRLHKAQEAPGTNGSLVLATPGAGARPEPDSLQARLGQLQRN 379
+L ++ LQ +++ + + ++ A A L + QRN
Sbjct: 1412 SSLEKTKHRLQNEIEDLMVDVERSNAAA-----------------------AALDKKQRN 1448
Query: 380 LSELHMTTARREEELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVN 439
++ ++ EE Q LE + E+ +L + +E+ + + +R+ + LQ
Sbjct: 1449 FDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEE 1508
Query: 440 HTALRELRVILMEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYL 499
+ L E + +E+ ++++E + +EL L+ +
Sbjct: 1509 ISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEAS------------------ 1550
Query: 500 DLDVIREGQRDATRALEETQVSLDERRQL---DGSSLQALQN---AVDAVSLAVDAHKAE 553
+ E + LE Q+ + R+L D QA +N VD++ ++DA
Sbjct: 1551 ---LEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRS 1607
Query: 554 GERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQLHSAF---AALLEDALRHEAVL 610
A ++ + ++ ++ AAEA+ +V+ L S L+DA+R
Sbjct: 1608 RNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR----- 1662
Query: 611 AALFGEEVLEEMS--EQTPGPLPLSYEQIRVALQ--DAASGLQEQALGWDELAARVTALE 666
+++ E ++ E+ L E++R ++ + + L EQ L E + RV L
Sbjct: 1663 ---ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQEL--IETSERVQLL- 1716
Query: 667 QASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASL 726
H + + +++ L+ L E++ + V C AE A A
Sbjct: 1717 ----------HSQNTSLINQKKKMDADLSQLQTEVE------EAVQECRNAEEKAKKAIT 1760
Query: 727 NASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSRKGKKQQK 786
+A++ + L Q + +R+ ++ + L L + + + + GKKQ +
Sbjct: 1761 DAAM--MAEELKKEQDTSAHLERMKKNMEQTIKDLQHR-----LDEAEQIALKGGKKQLQ 1813
Query: 787 DLEAPRKRDKKEAE 800
LEA + + E E
Sbjct: 1814 KLEARVRELENELE 1827
>gi|21389505 janus kinase and microtubule interacting protein 1
isoform 2 [Homo sapiens]
Length = 626
Score = 57.4 bits (137), Expect = 6e-08
Identities = 57/207 (27%), Positives = 98/207 (47%), Gaps = 21/207 (10%)
Query: 392 EELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTA-LRELRVIL 450
+ +Q E++RA LT E ++ S+ + +++ + + + E+ Q HTA + EL+ L
Sbjct: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKL 76
Query: 451 MEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRD 510
E E+ KE Q L L QH Q A +K+ Q+L L+V+R+G D
Sbjct: 77 HE-----EKTKE---LQALREGLIRQHEQ--EAARTAKIKEGELQRLQATLNVLRDGAAD 126
Query: 511 ATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKA-----EGERARAATSRLR 565
+ T+ + RR DG L+ Q ++ + A +A + ++ +AA LR
Sbjct: 127 KVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD--LR 184
Query: 566 SQVQALDDEVGALKAAAAEARHEVRQL 592
+ QA DEV +K E ++R+L
Sbjct: 185 AAYQAHQDEVHRIK---RECERDIRRL 208
>gi|150456473 janus kinase and microtubule interacting protein 1
isoform 1 [Homo sapiens]
Length = 831
Score = 57.4 bits (137), Expect = 6e-08
Identities = 57/207 (27%), Positives = 98/207 (47%), Gaps = 21/207 (10%)
Query: 392 EELQYTLEDMRATLTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTA-LRELRVIL 450
+ +Q E++RA LT E ++ S+ + +++ + + + E+ Q HTA + EL+ L
Sbjct: 17 DAVQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKL 76
Query: 451 MEKSLIMEENKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRD 510
E E+ KE Q L L QH Q A +K+ Q+L L+V+R+G D
Sbjct: 77 HE-----EKTKE---LQALREGLIRQHEQ--EAARTAKIKEGELQRLQATLNVLRDGAAD 126
Query: 511 ATRALEETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKA-----EGERARAATSRLR 565
+ T+ + RR DG L+ Q ++ + A +A + ++ +AA LR
Sbjct: 127 KVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTKAAD--LR 184
Query: 566 SQVQALDDEVGALKAAAAEARHEVRQL 592
+ QA DEV +K E ++R+L
Sbjct: 185 AAYQAHQDEVHRIK---RECERDIRRL 208
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 57.4 bits (137), Expect = 6e-08
Identities = 132/594 (22%), Positives = 240/594 (40%), Gaps = 76/594 (12%)
Query: 246 RSFNQSLHSLTQAIRNLSLDVEANRQAI--SRVQDSAVARADFQELGAKFEAKVQENTQR 303
R + L +L + + +LD A +Q + R Q+ V + E EA+VQE Q+
Sbjct: 1142 RDLGEELEALKTELED-TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQK 1200
Query: 304 VGQLRQDVEDRLHAQHFTLHRSISELQADVDTKLKRLHKAQEAPGTNGSL-VLATPGAGA 362
Q +++ ++L +A++D + L K E G L VL
Sbjct: 1201 HAQAVEELTEQLE--------QFKRAKANLDKNKQTLEK--ENADLAGELRVLGQAKQEV 1250
Query: 363 RPEPDSLQARLGQLQRNLSELHMTTARREEE---LQYTLEDMRATLT-------RHVDEI 412
+ L+A++ +LQ S+ A ++ LQ +E + L + ++
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 413 KELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELN 472
L S+ +T + + + RQ + L E R L ++ E K+ +ER + LN
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 473 L--------------TLQHLQGGHADLIKYVKDCNCQ--KLYLDLDVIREGQRDATRALE 516
+ T++ L+ G K +++ Q + D + + + + L+
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 517 ETQVSLDERRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVG 576
+ V LD +RQL S+L+ Q D + LA + + + ++ A R R++ +A + E
Sbjct: 1431 DLVVDLDNQRQL-VSNLEKKQRKFDQL-LAEEKNIS----SKYADERDRAEAEAREKETK 1484
Query: 577 ALKAA-----AAEARHEVRQLHSAFAALLEDALRHEAVLAALFGEEVLEEMSEQTPGPLP 631
AL A A EA+ E+ + + A +ED + + + G+ V E E++ L
Sbjct: 1485 ALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV----GKNVHE--LEKSKRALE 1538
Query: 632 LSYEQIRVALQDAASGLQEQALGWDELAARVTAL------------EQASEPPRPAEHLE 679
E+++ L++ LQ L + AL EQ E R +
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 680 PSHDAGRE-EAATTALAGLARELQSLSNDVKNVGRCCEAEAGAGAASLNASLHGLHNALF 738
++ E E ALA A+ + L D+K++ ++ A G L L +
Sbjct: 1599 HEYETELEDERKQRALAAAAK--KKLEGDLKDLELQADS-AIKGREEAIKQLRKLQAQMK 1655
Query: 739 ATQRSLEQHQRLFHSLFGNFQGLMEANVSL--DLGKLQTMLSRKGK-KQQKDLE 789
QR LE + +F + + SL DL +LQ L+ + ++Q DLE
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Score = 49.3 bits (116), Expect = 2e-05
Identities = 83/389 (21%), Positives = 162/389 (41%), Gaps = 53/389 (13%)
Query: 250 QSLHSLTQAIRNLSLDVEANRQAISRVQDSAVARADFQELGAKFEAKVQENTQRVGQLRQ 309
Q L + + + LD+E ++++ AR Q EAK+++ + +
Sbjct: 939 QQLQAERKKMAQQMLDLE------EQLEEEEAARQKLQLEKVTAEAKIKKLEDEI-LVMD 991
Query: 310 DVEDRLHAQHFTLHRSISELQADVD---------TKLKRLHKAQEAPGTNGSLVLATPGA 360
D ++L + L IS+L ++ TKLK H++ + V
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESM----ISELEVRLKKEE 1047
Query: 361 GARPEPDSLQARL-----------GQLQRNLSELHMTTARREEELQYT---LEDMRATLT 406
+R E + L+ +L LQ ++EL M A++EEELQ L+D A
Sbjct: 1048 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKN 1107
Query: 407 RHVDEIKEL---YSESDETFDQ----ISKVERQVEELQVNHTALRELRVILMEKSLIMEE 459
+ +I+EL S+ E D +K E+Q +L AL+ ++ + +E
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 460 NKEEVERQLLELNLTLQHLQGGHADLIKYVKDCNCQ---KLYLDLDVIREGQRDATR--- 513
+ + E+++ L L H ++ ++ + Q +L L+ + + + +
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 514 ALEETQVSLDERRQLDGSSLQALQN---AVDAVSLAVDAHKAEGERARAATSRLRSQVQA 570
LE+ L ++ G + Q +++ ++A + + ++GERARA L +V
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARA---ELNDKVHK 1284
Query: 571 LDDEVGALKAAAAEARHEVRQLHSAFAAL 599
L +EV ++ EA + +L A+L
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Score = 47.8 bits (112), Expect = 5e-05
Identities = 95/488 (19%), Positives = 191/488 (39%), Gaps = 86/488 (17%)
Query: 166 VINEVEVQQEQQEHLLGDLQNDVHRVADSLPGLWKALPGNLTAAVMEANQTGHEFPDRSL 225
+++ +E +Q + + LL + +N + AD T A+ A R+L
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA---------RAL 1492
Query: 226 EQVL-----LPHVDTFLQVHFSPIWRS---FNQSLHSLTQAIRNLSLDVEANRQAISRVQ 277
E+ L L + L+ + S +++H L ++ R L +E + + ++
Sbjct: 1493 EEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552
Query: 278 DSAVARAD--------FQELGAKFEAKVQENTQRVGQLRQDVEDRLHAQHFTLH-----R 324
D A D Q L +FE +Q ++ + R+ ++ +LH L R
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612
Query: 325 SIS--------------ELQADVDTK-----LKRLHKAQ----------EAPGTNGSLVL 355
+++ ELQAD K +K+L K Q E + +
Sbjct: 1613 ALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF 1672
Query: 356 ATPGAGARPEPDSLQARLGQLQRNLSELHMTTARREEELQYTLEDMRATLTRHVDEIKEL 415
AT + + SL+A L QLQ +L+ + + E + E++ ++L+ L
Sbjct: 1673 ATAKENEK-KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGR----NAL 1727
Query: 416 YSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVERQLLELNLTL 475
E +I+++E ++EE Q N A+ + + K+ + E++ +L T
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDR----VRKAT---QQAEQLSNELATERSTA 1780
Query: 476 QHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDER-------RQL 528
Q + L + K+ KL+ ++ + ALE L+E+ +Q
Sbjct: 1781 QKNESARQQLERQNKELR-SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839
Query: 529 DGSSLQALQNAVDAVSLAV-------DAHKAEGERARAATSRLRSQVQALDDEVGALKAA 581
SL+ + + L V + +K + E+ A +L+ Q++ ++E + A
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 582 AAEARHEV 589
+ + E+
Sbjct: 1900 RRKLQREL 1907
Score = 45.1 bits (105), Expect = 3e-04
Identities = 65/314 (20%), Positives = 122/314 (38%), Gaps = 54/314 (17%)
Query: 405 LTRHVDEIKELYSESDETFDQISKVERQVEELQVNHTALRELRVILMEKSLIMEENKEEV 464
+TR +E++ E +T ++ K E +++EL+ H+ L E + +L E+ E E
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 465 ERQLLELNLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDE 524
E + L Q L +++ +++ E + D + L+ E
Sbjct: 907 EEMRVRLAAKKQEL----------------EEILHEMEARLEEEEDRGQQLQA------E 944
Query: 525 RRQLDGSSLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAE 584
R+++ L L+ ++ A + E A A +L ++ +DD+ L
Sbjct: 945 RKKMAQQMLD-LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1003
Query: 585 ARHEVRQLHSAFAALLEDAL-------RHEAVLAALFGEEVLEEMSEQTPGPLPLSYEQI 637
+ L + A E A +HE++++ L EE S Q E++
Sbjct: 1004 LEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-------ELEKL 1056
Query: 638 RVALQDAASGLQEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGL 697
+ L+ AS EQ +L A++ L+ A +EE ALA L
Sbjct: 1057 KRKLEGDASDFHEQIA---DLQAQIAELKMQL--------------AKKEEELQAALARL 1099
Query: 698 ARELQSLSNDVKNV 711
E+ +N +K +
Sbjct: 1100 DDEIAQKNNALKKI 1113
Score = 40.4 bits (93), Expect = 0.008
Identities = 100/452 (22%), Positives = 185/452 (40%), Gaps = 70/452 (15%)
Query: 375 QLQRNLSELHMTTARR---EEELQYTLEDMRATLTRHVDEIKE-------LYSESDETFD 424
++Q EL T R+ E EL+ LE + LT + ++E LY+E++E
Sbjct: 853 EMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 425 QIS-----------KVERQVEELQVNHTALRELRVILMEKSLIMEENKEEVE--RQLLEL 471
+++ ++E ++EE + L+ R + ++ L +EE EE E RQ L+L
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971
Query: 472 NLTLQHLQGGHADLIKYVKDCNCQKLYLDLDVIREGQRDATRALEETQVSLDERRQLDGS 531
+ + V D KL + ++ E D T L E +
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK--------AK 1023
Query: 532 SLQALQNAVDAVSLAVDAHKAEGERARAATSRLRSQVQALDDEVGALKAAAAEARHEVRQ 591
+L L+N +++ ++ + E++R +L+ + L+ A++ ++
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK----------LEGDASDFHEQIAD 1073
Query: 592 LHSAFAAL-LEDALRHEAVLAAL--FGEEVLEEMSEQTPGPLPLSYEQIRVALQDAASGL 648
L + A L ++ A + E + AAL +E+ ++ + + ++IR L+ S L
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN---------ALKKIR-ELEGHISDL 1123
Query: 649 QEQALGWDELAARVTALEQASEPPRPAEHLEPSHDAGREEAATTALAGLARELQSLSNDV 708
QE E AAR A +Q + E L+ + + AT RE +V
Sbjct: 1124 QEDL--DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE-----QEV 1176
Query: 709 KNVGRCCEAEAGAGAASLNASLHGLHNALFATQRSLEQHQRLFHSLFGNFQGLMEANVSL 768
+ + + E + A + A+ LEQ +R +L N Q L + N L
Sbjct: 1177 TVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236
Query: 769 DLGKLQTMLSRKGKKQQKDLEAPRKRDKKEAE 800
G+L+ + G+ +Q E K+ K EA+
Sbjct: 1237 -AGELRVL----GQAKQ---EVEHKKKKLEAQ 1260
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,859,736
Number of Sequences: 37866
Number of extensions: 1775260
Number of successful extensions: 9609
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 523
Number of HSP's that attempted gapping in prelim test: 7714
Number of HSP's gapped (non-prelim): 1760
length of query: 949
length of database: 18,247,518
effective HSP length: 112
effective length of query: 837
effective length of database: 14,006,526
effective search space: 11723462262
effective search space used: 11723462262
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.