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Search of human proteins with 221136814
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|221136814 coiled-coil domain containing 154 [Homo sapiens]
(667 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|221136814 coiled-coil domain containing 154 [Homo sapiens] 1287 0.0
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 86 8e-17
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 86 1e-16
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 86 1e-16
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 86 1e-16
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 86 1e-16
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 86 1e-16
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 86 1e-16
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 86 1e-16
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 86 1e-16
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 84 4e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 80 6e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 80 6e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 80 6e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 80 6e-15
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 77 7e-14
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 77 7e-14
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 77 7e-14
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 77 7e-14
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 75 2e-13
gi|38044112 restin isoform b [Homo sapiens] 75 3e-13
gi|4506751 restin isoform a [Homo sapiens] 75 3e-13
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 75 3e-13
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 72 1e-12
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 72 2e-12
gi|156104908 myosin heavy chain 6 [Homo sapiens] 69 1e-11
gi|110611218 ribosome binding protein 1 [Homo sapiens] 69 1e-11
gi|110611220 ribosome binding protein 1 [Homo sapiens] 69 1e-11
gi|21735548 centrosomal protein 2 [Homo sapiens] 69 1e-11
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 69 1e-11
>gi|221136814 coiled-coil domain containing 154 [Homo sapiens]
Length = 667
Score = 1287 bits (3331), Expect = 0.0
Identities = 667/667 (100%), Positives = 667/667 (100%)
Query: 1 MSELADSGPSGASAPSQLRAVTLEDLGLLLAGGLASPEPLSLEELSERYESSHPTSTASV 60
MSELADSGPSGASAPSQLRAVTLEDLGLLLAGGLASPEPLSLEELSERYESSHPTSTASV
Sbjct: 1 MSELADSGPSGASAPSQLRAVTLEDLGLLLAGGLASPEPLSLEELSERYESSHPTSTASV 60
Query: 61 PEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQ 120
PEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQ
Sbjct: 61 PEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQ 120
Query: 121 LQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQE 180
LQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQE
Sbjct: 121 LQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQE 180
Query: 181 AGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFL 240
AGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFL
Sbjct: 181 AGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFL 240
Query: 241 KREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQ 300
KREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQ
Sbjct: 241 KREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQ 300
Query: 301 HEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYV 360
HEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYV
Sbjct: 301 HEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYV 360
Query: 361 QENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQ 420
QENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQ
Sbjct: 361 QENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQ 420
Query: 421 EQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLL 480
EQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLL
Sbjct: 421 EQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLL 480
Query: 481 HKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQI 540
HKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQI
Sbjct: 481 HKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQI 540
Query: 541 MKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPRTPLGSWKALPSLVR 600
MKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPRTPLGSWKALPSLVR
Sbjct: 541 MKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPRTPLGSWKALPSLVR 600
Query: 601 PRVFIKDMAPGKVVPMNCWGVYQAVRWLRWKASLIKLRALRRPGGVLEKPHSQEQVQQLT 660
PRVFIKDMAPGKVVPMNCWGVYQAVRWLRWKASLIKLRALRRPGGVLEKPHSQEQVQQLT
Sbjct: 601 PRVFIKDMAPGKVVPMNCWGVYQAVRWLRWKASLIKLRALRRPGGVLEKPHSQEQVQQLT 660
Query: 661 PSLFIQK 667
PSLFIQK
Sbjct: 661 PSLFIQK 667
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 86.3 bits (212), Expect = 8e-17
Identities = 122/503 (24%), Positives = 224/503 (44%), Gaps = 56/503 (11%)
Query: 80 QAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEF 139
Q +V +R + + +L ++L + + +L++L+ + A QA E E
Sbjct: 532 QLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREV 591
Query: 140 SGLQNQMQALDKRLVEVREAL--TRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQ 197
L++ + L + + +L + + +++QE E+ A QE L + D L+ EEQ
Sbjct: 592 QRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQE---ELRRQRDRLE-EEQ 647
Query: 198 GREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLAL 257
V GA + + + S R ++ +++ + + L +E+ REA LQ+ L
Sbjct: 648 EDAVQDGARVRRELERSHR---QLEQLEGKRSVLAKEL---VEVREALSRATLQRDMLQA 701
Query: 258 EKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAV 317
EK A + L + R ELE KLR EE+ L + L A
Sbjct: 702 EK---AEVAEALTKAEAGRVELELSMTKLRA-------------EEASLQDSLSKLSA-- 743
Query: 318 AQLTKFVQQNQASLNRVL--LAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELAR 375
L + + Q++ LNR++ L EEK+ + + + +A QE LE +L E+AR
Sbjct: 744 --LNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVAR 801
Query: 376 QEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEW 435
Q + G L + + ALE + L + +L L LS +L +EQ L EA+ +
Sbjct: 802 QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861
Query: 436 EGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKA 495
E ER AR ++ + + G+ ++ ++ ++S++ R+ E +A
Sbjct: 862 EALER-----AAREKEALAKEHAGLAVQLVAAEREGRTLSEEA--------TRLRLEKEA 908
Query: 496 REFKVGALRQELATLLSSVQLLKEDNPGRKIAE--MQGKLATFQNQIM------KLENCV 547
E + ++++LA L + + L+ + +A+ + G+LA + QI+ L+ +
Sbjct: 909 LEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKEL 968
Query: 548 QANKTIQNLRFNTEARLRTQEMA 570
A K +Q R +A LR Q A
Sbjct: 969 MAQKLVQAER-EAQASLREQRAA 990
Score = 78.2 bits (191), Expect = 2e-14
Identities = 123/531 (23%), Positives = 217/531 (40%), Gaps = 64/531 (12%)
Query: 3 ELADSGPSGASAPSQLRAVTLEDLGLLLAGGLASPEPLSLEELSERY--ESSHPTSTASV 60
+L+DS + QL+ + + G + A A E L +E E S+ + V
Sbjct: 555 QLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQV 614
Query: 61 PEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQ 120
+Q +L Q +LQA LR + R E +++ +VR ++ +L Q
Sbjct: 615 AQQQA----EELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQ 670
Query: 121 LQQEARPAAQ--APEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAE 178
L+ + A+ +EA + LQ M +K EV EALT+ +V+ E
Sbjct: 671 LEGKRSVLAKELVEVREALSRATLQRDMLQAEK--AEVAEALTKAEAGRVELE------- 721
Query: 179 QEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLR 238
+T L +E ++ N+ + ++DL Q + K + R
Sbjct: 722 -------LSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQR 774
Query: 239 FLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQ 298
++EA + Q+ LE+ E +R LEGSLR E+ + +E++L L
Sbjct: 775 QAEQEATVAREEQE---RLEELRLEQEVARQGLEGSLRVA-----EQAQEALEQQLPTL- 825
Query: 299 GQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAA 358
+HE S L EQ L ++ + ++Q + R + A E+A K L + AG
Sbjct: 826 -RHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQ 884
Query: 359 YVQENLEAAQLAGE-----LARQEMHGELVLLREKSRALEASVAQ--------------L 399
V E L+ E L ++ + G L ++ + LEA Q L
Sbjct: 885 LVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETL 944
Query: 400 AGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSL----EDLARWRKEVTE 455
G+L L + A + L ++++ +L +A+ E + + R+ EDL R ++E
Sbjct: 945 TGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA 1004
Query: 456 HLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQE 506
R + + L Q++ ++ L R+ AE + ++ AL+QE
Sbjct: 1005 AWRELEAERAQLQSQLQREQEELL-------ARLEAEKEELSEEIAALQQE 1048
Score = 74.7 bits (182), Expect = 3e-13
Identities = 134/553 (24%), Positives = 228/553 (41%), Gaps = 75/553 (13%)
Query: 34 LASPEPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRC 93
+A E LEEL E + S+ + A+ LEQ + L+ E + L+E +
Sbjct: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE--ALEQQLPTLRHERSQLQEQLAQL 839
Query: 94 ERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQ----------APEKE----APEF 139
R +EL Q R Q Q L + +E A+ A E+E + E
Sbjct: 840 SRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEA 899
Query: 140 SGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGR 199
+ L+ + +AL+ L EV+ L +L R+ Q EAE + LL +E
Sbjct: 900 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQAL-------------LLAKETLTG 946
Query: 200 EVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEK 259
E+A L++ + + L+ M ++ + E ++ A LQ+ E
Sbjct: 947 ELA--GLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA 1004
Query: 260 RMKASESSRLKLEGSLRGELE---SRWEKLRGLMEERLRALQGQHEESHLL---EQCQGL 313
+ E+ R +L+ L+ E E +R E + + E + ALQ + +E LL E+ Q L
Sbjct: 1005 AWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQAL 1064
Query: 314 DAAVAQLTKFVQQNQASLNRV----LLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQL 369
++ T ++ + + + L E + DA+ R E+ R+ A + L +
Sbjct: 1065 SLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNA--LTSELRDLRA 1122
Query: 370 AGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSS-----RLDLQEQML 424
E A E+ L+E++R L + +EL L L R +L E
Sbjct: 1123 QREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQR 1182
Query: 425 GLRLS----EAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLL 480
LR S E + + G R+SL + A+ R E LR E++ ++ ES L
Sbjct: 1183 KLRESQEGREVQRQEAGELRRSLGEGAKER----EALRRSNEELRSAVKKAESERISLKL 1238
Query: 481 HKSDSDLRISAEGKAR--------EFKVGA---------LRQELATLLSSVQLLKEDNP- 522
D + +++ +AR E + G R+EL L +++L +N
Sbjct: 1239 ANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTR 1298
Query: 523 -GRKIAEMQGKLA 534
GR++AE+QG+LA
Sbjct: 1299 LGRELAELQGRLA 1311
Score = 70.1 bits (170), Expect = 6e-12
Identities = 130/550 (23%), Positives = 231/550 (42%), Gaps = 58/550 (10%)
Query: 33 GLASPEPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQR 92
GL SP L S+ TS AS P+ D L +++ EL++ + +
Sbjct: 1473 GLNSPSTLECSPGSQPPSPGPATSPAS-PDLDPEAVRGALREFLQELRSA----QRERDE 1527
Query: 93 CERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKR 152
T +L R+L ++ A S RQLQ+ + +A SG+Q ++ AL +
Sbjct: 1528 LRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAEL-ALQEE 1586
Query: 153 LVEVREALTR--------LRRRQVQQEAERRGAEQEAGLRLAKLTDL---------LQQE 195
V E R L R E+E R ++++ A T L +
Sbjct: 1587 SVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDA 1646
Query: 196 EQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEV-SLRFLKREAKL-CGFLQKS 253
+ R V +++ E +R L ++ +AQ L + V SL+ ++++ G LQ +
Sbjct: 1647 SESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLT 1706
Query: 254 FLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQ-------HEESHL 306
L + E S L +RG E+ + L R + L Q H+ L
Sbjct: 1707 VERLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVL 1766
Query: 307 LEQC----QGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQE 362
E+ Q L A Q + +Q Q V E + +A+G+L++ R E+ QE
Sbjct: 1767 QERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLR--EVLRQRQE 1824
Query: 363 NLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQ 422
EAA L Q++ E LL+E+ +L+ ++AQL + +E+ S L L++
Sbjct: 1825 G-EAAALN---TVQKLQDERRLLQERLGSLQRALAQLEAEKREVE------RSALRLEKD 1874
Query: 423 MLGLRLSEAKTEWEGAERKSLEDLARWRKE---VTEHLRGVREKVDGLPQQIESV-SDKC 478
+ LR + K E E + +S ED R E + L G ++ +QI+ + +
Sbjct: 1875 RVALRRTLDKVERE--KLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVV 1932
Query: 479 LLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQN 538
+L +S S ++ + + ++ + L+QE+ L S+ + R+ A Q ++ +
Sbjct: 1933 VLEQSHSPAQLEVDAQQQQLE---LQQEVERLRSAQAQTERTLEARERAHRQ-RVRGLEE 1988
Query: 539 QIMKLENCVQ 548
Q+ L+ +Q
Sbjct: 1989 QVSTLKGQLQ 1998
Score = 61.2 bits (147), Expect = 3e-09
Identities = 96/382 (25%), Positives = 156/382 (40%), Gaps = 51/382 (13%)
Query: 94 ERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKR- 152
ER R Q R+ V SELR L+ + AA A A E LQ Q + L K+
Sbjct: 1093 ERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAA---HAQEVRRLQEQARDLGKQR 1149
Query: 153 ---LVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKN 209
L E E T+LR + ++ RR L + L++ ++GREV Q+
Sbjct: 1150 DSCLREAEELRTQLRLLEDARDGLRR--------ELLEAQRKLRESQEGREV-----QRQ 1196
Query: 210 QEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRL 269
+ RR E A+ + + + EE+ K E++ L+ + E+++ E +R
Sbjct: 1197 EAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERIS-LKLANEDKEQKLALLEEART 1255
Query: 270 KLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQA 329
+ G GEL + GL E L+ + E L Q + LD+ +L + + + Q
Sbjct: 1256 AV-GKEAGELRT------GLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQG 1308
Query: 330 SLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKS 389
L A G E + +++ L + + E+ RQE+ L+E+
Sbjct: 1309 RL------------ALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQE 1356
Query: 390 RALEASVAQLAGQLKELSG-------HLPALSSRLD---LQEQMLGLRLSEAKTEWEGAE 439
+L G L+E G H L +L+ + LGLRLS A+ +G E
Sbjct: 1357 GEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLE 1416
Query: 440 RKSLEDLARWRKEVTEHLRGVR 461
+ L + R+ L G+R
Sbjct: 1417 AE-LARVEVQRRAAEAQLGGLR 1437
Score = 56.6 bits (135), Expect = 7e-08
Identities = 111/501 (22%), Positives = 202/501 (40%), Gaps = 61/501 (12%)
Query: 72 LEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQ-------GSELRQLQQE 124
LE+ + E LR Q ER+ REL ++R ++++ G EL +LQ
Sbjct: 1250 LEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGR 1309
Query: 125 ARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLR 184
+A ++ E GL+ ++ + L +R+ L +R+ +QE E R E+
Sbjct: 1310 LALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERR---- 1365
Query: 185 LAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREA 244
LL E+ R +K Q D +R ++L++ +A+ +LG LR E
Sbjct: 1366 ------LLGSLEEAR-----GTEKQQLDHARGLELKLEAARAEAAELG----LRLSAAEG 1410
Query: 245 KLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEES 304
+ G L+ +E + +A+E+ L +LR R L R + G
Sbjct: 1411 RAQG-LEAELARVEVQRRAAEAQLGGLRSALR-----RGLGLGRAPSPAPRPVPGSPARD 1464
Query: 305 HLLE-QCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQEN 363
E +GL++ + L S D E+ G L ++QE
Sbjct: 1465 APAEGSGEGLNSP-STLECSPGSQPPSPGPATSPASPDLD-----PEAVRGALREFLQEL 1518
Query: 364 LEAAQLAGELARQ---------EMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALS 414
A + EL Q EM E ++R L+ +VA+ + + G L +
Sbjct: 1519 RSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQ 1578
Query: 415 SRLDLQEQMLGLRLSEAKTEWEGA---ER--KSLEDLARWRKEVTEHLRGVREKVDGLPQ 469
+ L LQE+ + E + + ER ++ E R +E ++ K++G +
Sbjct: 1579 AELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKR 1638
Query: 470 QIESVSDKCLLHKSDSDL-RISAEGKAREFKVGALRQELATLLSSVQLLKE--DNPGRKI 526
+++ V D +L R S EG+ + ++G +E + Q L++ D+ R++
Sbjct: 1639 RLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDRE-----AQAQALQDRVDSLQRQV 1693
Query: 527 AEMQGKLATFQNQIMKLENCV 547
A+ + K T Q + +L +
Sbjct: 1694 ADSEVKAGTLQLTVERLNGAL 1714
Score = 48.5 bits (114), Expect = 2e-05
Identities = 132/597 (22%), Positives = 235/597 (39%), Gaps = 94/597 (15%)
Query: 63 QDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQ 122
Q+ + L+ L E+A L+ ERA + RE L +R R+ + L ++
Sbjct: 1283 QELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMR 1342
Query: 123 QEARPAAQAPEKEAPEFSGLQNQ-MQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEA 181
QE + A + +++ EF + + + +L++ ++ L R +++ EA R A E
Sbjct: 1343 QELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEA-AEL 1401
Query: 182 GLRLAKL--------TDLLQQEEQGR--EVACGALQKNQEDSSRRVDLEVARMQAQVTKL 231
GLRL+ +L + E Q R E G L+ S+ R L + R + +
Sbjct: 1402 GLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLR-----SALRRGLGLGRAPSPAPRP 1456
Query: 232 GEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLME 291
R E G S LE + S +L+ E +RG +
Sbjct: 1457 VPGSPARDAPAEGSGEGLNSPS--TLECSPGSQPPSPGPATSPASPDLDP--EAVRGALR 1512
Query: 292 ERLRALQ-GQHEESHLLEQCQGLDAAVAQL-------TKFVQQNQASLNRVLLAEEKAWD 343
E L+ L+ Q E L Q L+ +A++ T +Q Q + V +EE
Sbjct: 1513 EFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKA---VAESEEARRS 1569
Query: 344 AKGRLEESRAGELAAYVQENLEAAQ----------LAGELARQEMHGELVLLREKSRALE 393
GRL +A ELA +E++ ++ E + Q EL +EK ++
Sbjct: 1570 VDGRLSGVQA-ELALQ-EESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMK 1627
Query: 394 ASVAQLAGQLKELSGHLPALSSRL------------DLQEQMLGLRLSEAKTE------- 434
A+ +L G + L L A SR +LQ LGL EA+ +
Sbjct: 1628 ANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQALQDRVD 1687
Query: 435 -----------WEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKS 483
G + ++E L +V E +R+KV GL + + + S L
Sbjct: 1688 SLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEAL-AQSSASLNSTR 1746
Query: 484 DSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNP--GRKIAEMQGKLATFQNQIM 541
D +L + A E L++ L ++ ++ + G ++ ++G++A + Q +
Sbjct: 1747 DKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRV 1806
Query: 542 KLENCVQ---------------ANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEE 583
+ E +Q A T+Q L+ E RL + + +L ++ +L +E+
Sbjct: 1807 EAEGQLQQLREVLRQRQEGEAAALNTVQKLQ--DERRLLQERLGSLQRALAQLEAEK 1861
Score = 47.8 bits (112), Expect = 3e-05
Identities = 107/464 (23%), Positives = 183/464 (39%), Gaps = 61/464 (13%)
Query: 72 LEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQA 131
LE + L++ V C Q R L ++ ++ R L Q P
Sbjct: 15 LETVIQTLESSVLC-----QEKGLGARDLAQDAQITSLPALIREIVTRNLSQPESPVL-L 68
Query: 132 PEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQ--EAGLRLAKLT 189
P E LQ + Q L + L V + L + R + + + + E LRL
Sbjct: 69 PATEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEP-G 127
Query: 190 DLLQQEEQGREVACGALQKNQEDSSRRVDLEVA--RMQAQVTKLGEEVSLRFLKREAKLC 247
+L QE +G L + + R++ E A R + Q + G++ R+A+L
Sbjct: 128 ELETQEPRG-------LVRQSVELRRQLQEEQASYRRKLQAYQEGQQ-------RQAQLV 173
Query: 248 GFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHL- 306
LQ L +KR E L+ G L + E + L +R + Q + L
Sbjct: 174 QRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLA 233
Query: 307 ---------LEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELA 357
L+Q + A+++ + V + + L E AW R EES
Sbjct: 234 QVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAW---RREEES----FN 286
Query: 358 AYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRL 417
AY E ++L L +++ G L+ E E + QL G+L S + L
Sbjct: 287 AYFSN--EHSRLL--LLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGL 342
Query: 418 DLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRG--VREKVDGLPQQIESVS 475
GLRL+E++ E +LE A + ++ E LR +REK D QQ++S
Sbjct: 343 S-----TGLRLAESRAE------AALEKQALLQAQLEEQLRDKVLREK-DLAQQQMQSDL 390
Query: 476 DKCLLHKSDSDLRISAEG-KAREFKVGALRQELATLLSSVQLLK 518
DK L ++L ++ + + + + + ++L L +++ L+
Sbjct: 391 DKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLR 434
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 85.5 bits (210), Expect = 1e-16
Identities = 150/603 (24%), Positives = 250/603 (41%), Gaps = 82/603 (13%)
Query: 40 LSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQR------- 92
++LE E+ + AS E+ QLE+ + E VA LRE +R
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTA-----QLERSLQEEHVAVAQLREEAERRAQQQAE 1619
Query: 93 CERATRSLLREL--LQVRA----RVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQM 146
ERA REL Q++A R++LQ E+ Q + A+ A+ ++EA + + +
Sbjct: 1620 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 147 QALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL 206
+ R E+ E +R+ + A++R A ++ +RL T+ +Q+ Q E L
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 207 QKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASES 266
Q R A T+ +E+ K A++ L A E+ SE
Sbjct: 1740 Q---------------REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1784
Query: 267 SRLKLE---GSLRGELESRWEKLRGLMEERLR---------ALQGQHEESHLLEQCQGLD 314
S+ +LE G R EL +LR L EE R A Q E L E+ +
Sbjct: 1785 SKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 315 AAVAQLTK---FVQQNQASLNRV-LLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLA 370
A T+ +++ +A R+ LAE++A+ + RLEE +A + A ++E L + A
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR-RLEE-QAAQHKADIEERLAQLRKA 1901
Query: 371 --GELARQEMHGELVL-----LREKSRALEASVAQLAGQLKELSGHLPALSSRLD----- 418
EL RQ+ E L + E+ AL+AS + A EL L + S +
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 419 --------LQEQMLGLRLSEAKTEWEGAERKSL---EDLARWRKEVTEHLRGVREKVD-- 465
+++ L + E E +KSL E+ AR RK E + ++ KV+
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 466 -GLPQQIESVSDKCL-LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPG 523
L ++ E S + L L + + R+ AE KA F V QEL L Q + + G
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 524 RKIAEMQGKLATFQNQIMKLENCVQANKTI---QNLRFNTEARLRTQEMATLWESVLRLW 580
A + + ++ Q+ + + + L+ + E + + + A LR
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 581 SEE 583
+E+
Sbjct: 2142 AEQ 2144
Score = 73.9 bits (180), Expect = 4e-13
Identities = 127/542 (23%), Positives = 224/542 (41%), Gaps = 60/542 (11%)
Query: 58 ASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSE 117
A Q A+ + ++ +Q EV E ++ RS+ EL Q+R Q +E
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR---QSSEAE 1432
Query: 118 LRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGA 177
++ ++A A ++ + E ++ Q++A +++ L LR R + EA++R A
Sbjct: 1433 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1492
Query: 178 EQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVD-----LEVARMQAQVTKLG 232
++EA ++ D Q++ Q EV + K + +++R LE R+QA
Sbjct: 1493 QEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEELRLQA------ 1545
Query: 233 EEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEE 292
EE R + E + +Q +ALE +++E+ +L+ E + R L EE
Sbjct: 1546 EEAERRLRQAEVERARQVQ---VALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEE 1599
Query: 293 RLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVL--------LAEEKAW-D 343
+ Q + E +Q + A + + +++ Q N L +A++K+
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659
Query: 344 AKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL 403
A+ ++ A A + E A ELA QE+ EK R L AQ
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL--------EKQRQLAEGTAQQRLAA 1711
Query: 404 KELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREK 463
++ L A + + + Q Q+L L+ + E A +K R+E+ L VR +
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK--------RQELEAELAKVRAE 1763
Query: 464 VDGLPQQIESVSDKCLLHKSDSDLRISAE-GKAREFKVGALR-QELATLLSSVQLLKEDN 521
++ L ++ S R+ AE G+ RE A R + LA + L E++
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 522 PGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWS 581
R+ AE + LA KL +A R TEA + +E E + RL
Sbjct: 1824 AARQRAEAERVLAE------KLAAIGEAT------RLKTEAEIALKEKEAENERLRRLAE 1871
Query: 582 EE 583
+E
Sbjct: 1872 DE 1873
Score = 65.5 bits (158), Expect = 2e-10
Identities = 146/589 (24%), Positives = 236/589 (40%), Gaps = 97/589 (16%)
Query: 35 ASPEPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCE 94
A L+ EE R E+ + E++ A+ + V L+A+V R ++R E
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 95 RATRSLLRELLQVRARVQLQGSE------------------------LRQLQQEARPAAQ 130
+ + L +L Q A+ +LQ E L QL+ EA A +
Sbjct: 2030 QESARQL-QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALT------------------RLRRRQVQQEA 172
A E EA E + A +R VE E L +LR+ Q+ A
Sbjct: 2089 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 173 ERRGAEQEAGLRLAKLTDLLQQEEQ--GREVACGALQKNQEDSSRRVDLEVARMQAQVTK 230
R AEQ A LR + D ++ + + Q QE ++ R+ LE Q +
Sbjct: 2148 RRAQAEQ-AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-- 2204
Query: 231 LGEEVSLRFLKREAKLCGFLQKSFLALE---KRMKASESSRLKLEGSLRGELESRWEKLR 287
L EE L+ LK EA Q+S + E R++ E S+LK R E E+R LR
Sbjct: 2205 LDEE--LQRLKAEATEAA-RQRSQVEEELFSVRVQMEELSKLK----ARIEAENRALILR 2257
Query: 288 GLMEERLRALQGQHEE-SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKG 346
+ R LQ + E+ + E+ L A + + Q + LA+++A K
Sbjct: 2258 D-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEKM 2311
Query: 347 RLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL-KE 405
E+ +A + A ++ E Q ELA +E++R L+ Q+A QL +E
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELA-----------QEQARRLQEDKEQMAQQLAEE 2360
Query: 406 LSGHLPALSSRLDLQEQML--GLRLSEAKTEWEGAERKSLEDLARWRK---EVTEHLR-- 458
G L + Q +M RL E A+ ++ ED R+RK E+ E L
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Query: 459 --GVREKVDGLP----QQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLS 512
+EKV + Q+ +S D L ++ ++L E +E K+ L+ E +
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2480
Query: 513 SVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTE 561
QLL+E +Q + ++ +++ E ++ K F E
Sbjct: 2481 QEQLLQETQ------ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523
Score = 36.6 bits (83), Expect = 0.077
Identities = 52/188 (27%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 34 LASPEPLSLEELSE--RYESSHPTSTA--SVPEQDTAKHWNQLEQWVVELQAEVACLREH 89
LA+ E ++L + E R +S H ++ E + K Q E +++L++E +
Sbjct: 2422 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481
Query: 90 KQRCERAT---RSLLRE---LLQVRARVQLQGSELRQL-QQEARPAAQAPEKEAPEFSGL 142
+Q + +S L E LLQ ++ + ++L QL Q E A Q E++ +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ---- 2537
Query: 143 QNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVA 202
Q QM+ +RLV E EA RR E E G+R K +L Q E+Q R+
Sbjct: 2538 QQQMEQERQRLVASME------------EARRRQHEAEEGVR-RKQEELQQLEQQRRQQE 2584
Query: 203 CGALQKNQ 210
++NQ
Sbjct: 2585 ELLAEENQ 2592
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 85.5 bits (210), Expect = 1e-16
Identities = 150/603 (24%), Positives = 250/603 (41%), Gaps = 82/603 (13%)
Query: 40 LSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQR------- 92
++LE E+ + AS E+ QLE+ + E VA LRE +R
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKTA-----QLERSLQEEHVAVAQLREEAERRAQQQAE 1623
Query: 93 CERATRSLLREL--LQVRA----RVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQM 146
ERA REL Q++A R++LQ E+ Q + A+ A+ ++EA + + +
Sbjct: 1624 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1683
Query: 147 QALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL 206
+ R E+ E +R+ + A++R A ++ +RL T+ +Q+ Q E L
Sbjct: 1684 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1743
Query: 207 QKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASES 266
Q R A T+ +E+ K A++ L A E+ SE
Sbjct: 1744 Q---------------REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1788
Query: 267 SRLKLE---GSLRGELESRWEKLRGLMEERLR---------ALQGQHEESHLLEQCQGLD 314
S+ +LE G R EL +LR L EE R A Q E L E+ +
Sbjct: 1789 SKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1847
Query: 315 AAVAQLTK---FVQQNQASLNRV-LLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLA 370
A T+ +++ +A R+ LAE++A+ + RLEE +A + A ++E L + A
Sbjct: 1848 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR-RLEE-QAAQHKADIEERLAQLRKA 1905
Query: 371 --GELARQEMHGELVL-----LREKSRALEASVAQLAGQLKELSGHLPALSSRLD----- 418
EL RQ+ E L + E+ AL+AS + A EL L + S +
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965
Query: 419 --------LQEQMLGLRLSEAKTEWEGAERKSL---EDLARWRKEVTEHLRGVREKVD-- 465
+++ L + E E +KSL E+ AR RK E + ++ KV+
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 466 -GLPQQIESVSDKCL-LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPG 523
L ++ E S + L L + + R+ AE KA F V QEL L Q + + G
Sbjct: 2026 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2085
Query: 524 RKIAEMQGKLATFQNQIMKLENCVQANKTI---QNLRFNTEARLRTQEMATLWESVLRLW 580
A + + ++ Q+ + + + L+ + E + + + A LR
Sbjct: 2086 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2145
Query: 581 SEE 583
+E+
Sbjct: 2146 AEQ 2148
Score = 73.9 bits (180), Expect = 4e-13
Identities = 127/542 (23%), Positives = 224/542 (41%), Gaps = 60/542 (11%)
Query: 58 ASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSE 117
A Q A+ + ++ +Q EV E ++ RS+ EL Q+R Q +E
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR---QSSEAE 1436
Query: 118 LRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGA 177
++ ++A A ++ + E ++ Q++A +++ L LR R + EA++R A
Sbjct: 1437 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1496
Query: 178 EQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVD-----LEVARMQAQVTKLG 232
++EA ++ D Q++ Q EV + K + +++R LE R+QA
Sbjct: 1497 QEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEELRLQA------ 1549
Query: 233 EEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEE 292
EE R + E + +Q +ALE +++E+ +L+ E + R L EE
Sbjct: 1550 EEAERRLRQAEVERARQVQ---VALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEE 1603
Query: 293 RLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVL--------LAEEKAW-D 343
+ Q + E +Q + A + + +++ Q N L +A++K+
Sbjct: 1604 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1663
Query: 344 AKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL 403
A+ ++ A A + E A ELA QE+ EK R L AQ
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL--------EKQRQLAEGTAQQRLAA 1715
Query: 404 KELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREK 463
++ L A + + + Q Q+L L+ + E A +K R+E+ L VR +
Sbjct: 1716 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK--------RQELEAELAKVRAE 1767
Query: 464 VDGLPQQIESVSDKCLLHKSDSDLRISAE-GKAREFKVGALR-QELATLLSSVQLLKEDN 521
++ L ++ S R+ AE G+ RE A R + LA + L E++
Sbjct: 1768 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1827
Query: 522 PGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWS 581
R+ AE + LA KL +A R TEA + +E E + RL
Sbjct: 1828 AARQRAEAERVLAE------KLAAIGEAT------RLKTEAEIALKEKEAENERLRRLAE 1875
Query: 582 EE 583
+E
Sbjct: 1876 DE 1877
Score = 65.5 bits (158), Expect = 2e-10
Identities = 146/589 (24%), Positives = 236/589 (40%), Gaps = 97/589 (16%)
Query: 35 ASPEPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCE 94
A L+ EE R E+ + E++ A+ + V L+A+V R ++R E
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2033
Query: 95 RATRSLLRELLQVRARVQLQGSE------------------------LRQLQQEARPAAQ 130
+ + L +L Q A+ +LQ E L QL+ EA A +
Sbjct: 2034 QESARQL-QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2092
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALT------------------RLRRRQVQQEA 172
A E EA E + A +R VE E L +LR+ Q+ A
Sbjct: 2093 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2151
Query: 173 ERRGAEQEAGLRLAKLTDLLQQEEQ--GREVACGALQKNQEDSSRRVDLEVARMQAQVTK 230
R AEQ A LR + D ++ + + Q QE ++ R+ LE Q +
Sbjct: 2152 RRAQAEQ-AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-- 2208
Query: 231 LGEEVSLRFLKREAKLCGFLQKSFLALE---KRMKASESSRLKLEGSLRGELESRWEKLR 287
L EE L+ LK EA Q+S + E R++ E S+LK R E E+R LR
Sbjct: 2209 LDEE--LQRLKAEATEAA-RQRSQVEEELFSVRVQMEELSKLK----ARIEAENRALILR 2261
Query: 288 GLMEERLRALQGQHEE-SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKG 346
+ R LQ + E+ + E+ L A + + Q + LA+++A K
Sbjct: 2262 D-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEKM 2315
Query: 347 RLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL-KE 405
E+ +A + A ++ E Q ELA +E++R L+ Q+A QL +E
Sbjct: 2316 LKEKMQAVQEATRLKAEAELLQQQKELA-----------QEQARRLQEDKEQMAQQLAEE 2364
Query: 406 LSGHLPALSSRLDLQEQML--GLRLSEAKTEWEGAERKSLEDLARWRK---EVTEHLR-- 458
G L + Q +M RL E A+ ++ ED R+RK E+ E L
Sbjct: 2365 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2424
Query: 459 --GVREKVDGLP----QQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLS 512
+EKV + Q+ +S D L ++ ++L E +E K+ L+ E +
Sbjct: 2425 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2484
Query: 513 SVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTE 561
QLL+E +Q + ++ +++ E ++ K F E
Sbjct: 2485 QEQLLQETQ------ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2527
Score = 36.6 bits (83), Expect = 0.077
Identities = 52/188 (27%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 34 LASPEPLSLEELSE--RYESSHPTSTA--SVPEQDTAKHWNQLEQWVVELQAEVACLREH 89
LA+ E ++L + E R +S H ++ E + K Q E +++L++E +
Sbjct: 2426 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2485
Query: 90 KQRCERAT---RSLLRE---LLQVRARVQLQGSELRQL-QQEARPAAQAPEKEAPEFSGL 142
+Q + +S L E LLQ ++ + ++L QL Q E A Q E++ +
Sbjct: 2486 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ---- 2541
Query: 143 QNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVA 202
Q QM+ +RLV E EA RR E E G+R K +L Q E+Q R+
Sbjct: 2542 QQQMEQERQRLVASME------------EARRRQHEAEEGVR-RKQEELQQLEQQRRQQE 2588
Query: 203 CGALQKNQ 210
++NQ
Sbjct: 2589 ELLAEENQ 2596
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 85.5 bits (210), Expect = 1e-16
Identities = 150/603 (24%), Positives = 250/603 (41%), Gaps = 82/603 (13%)
Query: 40 LSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQR------- 92
++LE E+ + AS E+ QLE+ + E VA LRE +R
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTA-----QLERSLQEEHVAVAQLREEAERRAQQQAE 1619
Query: 93 CERATRSLLREL--LQVRA----RVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQM 146
ERA REL Q++A R++LQ E+ Q + A+ A+ ++EA + + +
Sbjct: 1620 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1679
Query: 147 QALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL 206
+ R E+ E +R+ + A++R A ++ +RL T+ +Q+ Q E L
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 207 QKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASES 266
Q R A T+ +E+ K A++ L A E+ SE
Sbjct: 1740 Q---------------REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1784
Query: 267 SRLKLE---GSLRGELESRWEKLRGLMEERLR---------ALQGQHEESHLLEQCQGLD 314
S+ +LE G R EL +LR L EE R A Q E L E+ +
Sbjct: 1785 SKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1843
Query: 315 AAVAQLTK---FVQQNQASLNRV-LLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLA 370
A T+ +++ +A R+ LAE++A+ + RLEE +A + A ++E L + A
Sbjct: 1844 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR-RLEE-QAAQHKADIEERLAQLRKA 1901
Query: 371 --GELARQEMHGELVL-----LREKSRALEASVAQLAGQLKELSGHLPALSSRLD----- 418
EL RQ+ E L + E+ AL+AS + A EL L + S +
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 419 --------LQEQMLGLRLSEAKTEWEGAERKSL---EDLARWRKEVTEHLRGVREKVD-- 465
+++ L + E E +KSL E+ AR RK E + ++ KV+
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 466 -GLPQQIESVSDKCL-LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPG 523
L ++ E S + L L + + R+ AE KA F V QEL L Q + + G
Sbjct: 2022 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2081
Query: 524 RKIAEMQGKLATFQNQIMKLENCVQANKTI---QNLRFNTEARLRTQEMATLWESVLRLW 580
A + + ++ Q+ + + + L+ + E + + + A LR
Sbjct: 2082 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2141
Query: 581 SEE 583
+E+
Sbjct: 2142 AEQ 2144
Score = 73.9 bits (180), Expect = 4e-13
Identities = 127/542 (23%), Positives = 224/542 (41%), Gaps = 60/542 (11%)
Query: 58 ASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSE 117
A Q A+ + ++ +Q EV E ++ RS+ EL Q+R Q +E
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR---QSSEAE 1432
Query: 118 LRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGA 177
++ ++A A ++ + E ++ Q++A +++ L LR R + EA++R A
Sbjct: 1433 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1492
Query: 178 EQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVD-----LEVARMQAQVTKLG 232
++EA ++ D Q++ Q EV + K + +++R LE R+QA
Sbjct: 1493 QEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEELRLQA------ 1545
Query: 233 EEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEE 292
EE R + E + +Q +ALE +++E+ +L+ E + R L EE
Sbjct: 1546 EEAERRLRQAEVERARQVQ---VALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEE 1599
Query: 293 RLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVL--------LAEEKAW-D 343
+ Q + E +Q + A + + +++ Q N L +A++K+
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659
Query: 344 AKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL 403
A+ ++ A A + E A ELA QE+ EK R L AQ
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL--------EKQRQLAEGTAQQRLAA 1711
Query: 404 KELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREK 463
++ L A + + + Q Q+L L+ + E A +K R+E+ L VR +
Sbjct: 1712 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK--------RQELEAELAKVRAE 1763
Query: 464 VDGLPQQIESVSDKCLLHKSDSDLRISAE-GKAREFKVGALR-QELATLLSSVQLLKEDN 521
++ L ++ S R+ AE G+ RE A R + LA + L E++
Sbjct: 1764 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1823
Query: 522 PGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWS 581
R+ AE + LA KL +A R TEA + +E E + RL
Sbjct: 1824 AARQRAEAERVLAE------KLAAIGEAT------RLKTEAEIALKEKEAENERLRRLAE 1871
Query: 582 EE 583
+E
Sbjct: 1872 DE 1873
Score = 65.5 bits (158), Expect = 2e-10
Identities = 146/589 (24%), Positives = 236/589 (40%), Gaps = 97/589 (16%)
Query: 35 ASPEPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCE 94
A L+ EE R E+ + E++ A+ + V L+A+V R ++R E
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2029
Query: 95 RATRSLLRELLQVRARVQLQGSE------------------------LRQLQQEARPAAQ 130
+ + L +L Q A+ +LQ E L QL+ EA A +
Sbjct: 2030 QESARQL-QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2088
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALT------------------RLRRRQVQQEA 172
A E EA E + A +R VE E L +LR+ Q+ A
Sbjct: 2089 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2147
Query: 173 ERRGAEQEAGLRLAKLTDLLQQEEQ--GREVACGALQKNQEDSSRRVDLEVARMQAQVTK 230
R AEQ A LR + D ++ + + Q QE ++ R+ LE Q +
Sbjct: 2148 RRAQAEQ-AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-- 2204
Query: 231 LGEEVSLRFLKREAKLCGFLQKSFLALE---KRMKASESSRLKLEGSLRGELESRWEKLR 287
L EE L+ LK EA Q+S + E R++ E S+LK R E E+R LR
Sbjct: 2205 LDEE--LQRLKAEATEAA-RQRSQVEEELFSVRVQMEELSKLK----ARIEAENRALILR 2257
Query: 288 GLMEERLRALQGQHEE-SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKG 346
+ R LQ + E+ + E+ L A + + Q + LA+++A K
Sbjct: 2258 D-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEKM 2311
Query: 347 RLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL-KE 405
E+ +A + A ++ E Q ELA +E++R L+ Q+A QL +E
Sbjct: 2312 LKEKMQAVQEATRLKAEAELLQQQKELA-----------QEQARRLQEDKEQMAQQLAEE 2360
Query: 406 LSGHLPALSSRLDLQEQML--GLRLSEAKTEWEGAERKSLEDLARWRK---EVTEHLR-- 458
G L + Q +M RL E A+ ++ ED R+RK E+ E L
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2420
Query: 459 --GVREKVDGLP----QQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLS 512
+EKV + Q+ +S D L ++ ++L E +E K+ L+ E +
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2480
Query: 513 SVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTE 561
QLL+E +Q + ++ +++ E ++ K F E
Sbjct: 2481 QEQLLQETQ------ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2523
Score = 36.6 bits (83), Expect = 0.077
Identities = 52/188 (27%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 34 LASPEPLSLEELSE--RYESSHPTSTA--SVPEQDTAKHWNQLEQWVVELQAEVACLREH 89
LA+ E ++L + E R +S H ++ E + K Q E +++L++E +
Sbjct: 2422 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2481
Query: 90 KQRCERAT---RSLLRE---LLQVRARVQLQGSELRQL-QQEARPAAQAPEKEAPEFSGL 142
+Q + +S L E LLQ ++ + ++L QL Q E A Q E++ +
Sbjct: 2482 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ---- 2537
Query: 143 QNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVA 202
Q QM+ +RLV E EA RR E E G+R K +L Q E+Q R+
Sbjct: 2538 QQQMEQERQRLVASME------------EARRRQHEAEEGVR-RKQEELQQLEQQRRQQE 2584
Query: 203 CGALQKNQ 210
++NQ
Sbjct: 2585 ELLAEENQ 2592
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 85.5 bits (210), Expect = 1e-16
Identities = 150/603 (24%), Positives = 250/603 (41%), Gaps = 82/603 (13%)
Query: 40 LSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQR------- 92
++LE E+ + AS E+ QLE+ + E VA LRE +R
Sbjct: 1533 VALETAQRSAEAELQSKRASFAEKTA-----QLERSLQEEHVAVAQLREEAERRAQQQAE 1587
Query: 93 CERATRSLLREL--LQVRA----RVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQM 146
ERA REL Q++A R++LQ E+ Q + A+ A+ ++EA + + +
Sbjct: 1588 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1647
Query: 147 QALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL 206
+ R E+ E +R+ + A++R A ++ +RL T+ +Q+ Q E L
Sbjct: 1648 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1707
Query: 207 QKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASES 266
Q R A T+ +E+ K A++ L A E+ SE
Sbjct: 1708 Q---------------REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1752
Query: 267 SRLKLE---GSLRGELESRWEKLRGLMEERLR---------ALQGQHEESHLLEQCQGLD 314
S+ +LE G R EL +LR L EE R A Q E L E+ +
Sbjct: 1753 SKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1811
Query: 315 AAVAQLTK---FVQQNQASLNRV-LLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLA 370
A T+ +++ +A R+ LAE++A+ + RLEE +A + A ++E L + A
Sbjct: 1812 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR-RLEE-QAAQHKADIEERLAQLRKA 1869
Query: 371 --GELARQEMHGELVL-----LREKSRALEASVAQLAGQLKELSGHLPALSSRLD----- 418
EL RQ+ E L + E+ AL+AS + A EL L + S +
Sbjct: 1870 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929
Query: 419 --------LQEQMLGLRLSEAKTEWEGAERKSL---EDLARWRKEVTEHLRGVREKVD-- 465
+++ L + E E +KSL E+ AR RK E + ++ KV+
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Query: 466 -GLPQQIESVSDKCL-LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPG 523
L ++ E S + L L + + R+ AE KA F V QEL L Q + + G
Sbjct: 1990 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2049
Query: 524 RKIAEMQGKLATFQNQIMKLENCVQANKTI---QNLRFNTEARLRTQEMATLWESVLRLW 580
A + + ++ Q+ + + + L+ + E + + + A LR
Sbjct: 2050 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2109
Query: 581 SEE 583
+E+
Sbjct: 2110 AEQ 2112
Score = 73.9 bits (180), Expect = 4e-13
Identities = 127/542 (23%), Positives = 224/542 (41%), Gaps = 60/542 (11%)
Query: 58 ASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSE 117
A Q A+ + ++ +Q EV E ++ RS+ EL Q+R Q +E
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR---QSSEAE 1400
Query: 118 LRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGA 177
++ ++A A ++ + E ++ Q++A +++ L LR R + EA++R A
Sbjct: 1401 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1460
Query: 178 EQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVD-----LEVARMQAQVTKLG 232
++EA ++ D Q++ Q EV + K + +++R LE R+QA
Sbjct: 1461 QEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEELRLQA------ 1513
Query: 233 EEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEE 292
EE R + E + +Q +ALE +++E+ +L+ E + R L EE
Sbjct: 1514 EEAERRLRQAEVERARQVQ---VALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEE 1567
Query: 293 RLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVL--------LAEEKAW-D 343
+ Q + E +Q + A + + +++ Q N L +A++K+
Sbjct: 1568 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1627
Query: 344 AKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL 403
A+ ++ A A + E A ELA QE+ EK R L AQ
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL--------EKQRQLAEGTAQQRLAA 1679
Query: 404 KELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREK 463
++ L A + + + Q Q+L L+ + E A +K R+E+ L VR +
Sbjct: 1680 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK--------RQELEAELAKVRAE 1731
Query: 464 VDGLPQQIESVSDKCLLHKSDSDLRISAE-GKAREFKVGALR-QELATLLSSVQLLKEDN 521
++ L ++ S R+ AE G+ RE A R + LA + L E++
Sbjct: 1732 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1791
Query: 522 PGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWS 581
R+ AE + LA KL +A R TEA + +E E + RL
Sbjct: 1792 AARQRAEAERVLAE------KLAAIGEAT------RLKTEAEIALKEKEAENERLRRLAE 1839
Query: 582 EE 583
+E
Sbjct: 1840 DE 1841
Score = 65.5 bits (158), Expect = 2e-10
Identities = 146/589 (24%), Positives = 236/589 (40%), Gaps = 97/589 (16%)
Query: 35 ASPEPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCE 94
A L+ EE R E+ + E++ A+ + V L+A+V R ++R E
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 1997
Query: 95 RATRSLLRELLQVRARVQLQGSE------------------------LRQLQQEARPAAQ 130
+ + L +L Q A+ +LQ E L QL+ EA A +
Sbjct: 1998 QESARQL-QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2056
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALT------------------RLRRRQVQQEA 172
A E EA E + A +R VE E L +LR+ Q+ A
Sbjct: 2057 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2115
Query: 173 ERRGAEQEAGLRLAKLTDLLQQEEQ--GREVACGALQKNQEDSSRRVDLEVARMQAQVTK 230
R AEQ A LR + D ++ + + Q QE ++ R+ LE Q +
Sbjct: 2116 RRAQAEQ-AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-- 2172
Query: 231 LGEEVSLRFLKREAKLCGFLQKSFLALE---KRMKASESSRLKLEGSLRGELESRWEKLR 287
L EE L+ LK EA Q+S + E R++ E S+LK R E E+R LR
Sbjct: 2173 LDEE--LQRLKAEATEAA-RQRSQVEEELFSVRVQMEELSKLK----ARIEAENRALILR 2225
Query: 288 GLMEERLRALQGQHEE-SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKG 346
+ R LQ + E+ + E+ L A + + Q + LA+++A K
Sbjct: 2226 D-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEKM 2279
Query: 347 RLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL-KE 405
E+ +A + A ++ E Q ELA +E++R L+ Q+A QL +E
Sbjct: 2280 LKEKMQAVQEATRLKAEAELLQQQKELA-----------QEQARRLQEDKEQMAQQLAEE 2328
Query: 406 LSGHLPALSSRLDLQEQML--GLRLSEAKTEWEGAERKSLEDLARWRK---EVTEHLR-- 458
G L + Q +M RL E A+ ++ ED R+RK E+ E L
Sbjct: 2329 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2388
Query: 459 --GVREKVDGLP----QQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLS 512
+EKV + Q+ +S D L ++ ++L E +E K+ L+ E +
Sbjct: 2389 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2448
Query: 513 SVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTE 561
QLL+E +Q + ++ +++ E ++ K F E
Sbjct: 2449 QEQLLQETQ------ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2491
Score = 36.6 bits (83), Expect = 0.077
Identities = 52/188 (27%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 34 LASPEPLSLEELSE--RYESSHPTSTA--SVPEQDTAKHWNQLEQWVVELQAEVACLREH 89
LA+ E ++L + E R +S H ++ E + K Q E +++L++E +
Sbjct: 2390 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2449
Query: 90 KQRCERAT---RSLLRE---LLQVRARVQLQGSELRQL-QQEARPAAQAPEKEAPEFSGL 142
+Q + +S L E LLQ ++ + ++L QL Q E A Q E++ +
Sbjct: 2450 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ---- 2505
Query: 143 QNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVA 202
Q QM+ +RLV E EA RR E E G+R K +L Q E+Q R+
Sbjct: 2506 QQQMEQERQRLVASME------------EARRRQHEAEEGVR-RKQEELQQLEQQRRQQE 2552
Query: 203 CGALQKNQ 210
++NQ
Sbjct: 2553 ELLAEENQ 2560
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 85.5 bits (210), Expect = 1e-16
Identities = 150/603 (24%), Positives = 250/603 (41%), Gaps = 82/603 (13%)
Query: 40 LSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQR------- 92
++LE E+ + AS E+ QLE+ + E VA LRE +R
Sbjct: 1702 VALETAQRSAEAELQSKRASFAEKTA-----QLERSLQEEHVAVAQLREEAERRAQQQAE 1756
Query: 93 CERATRSLLREL--LQVRA----RVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQM 146
ERA REL Q++A R++LQ E+ Q + A+ A+ ++EA + + +
Sbjct: 1757 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1816
Query: 147 QALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL 206
+ R E+ E +R+ + A++R A ++ +RL T+ +Q+ Q E L
Sbjct: 1817 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1876
Query: 207 QKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASES 266
Q R A T+ +E+ K A++ L A E+ SE
Sbjct: 1877 Q---------------REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1921
Query: 267 SRLKLE---GSLRGELESRWEKLRGLMEERLR---------ALQGQHEESHLLEQCQGLD 314
S+ +LE G R EL +LR L EE R A Q E L E+ +
Sbjct: 1922 SKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980
Query: 315 AAVAQLTK---FVQQNQASLNRV-LLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLA 370
A T+ +++ +A R+ LAE++A+ + RLEE +A + A ++E L + A
Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR-RLEE-QAAQHKADIEERLAQLRKA 2038
Query: 371 --GELARQEMHGELVL-----LREKSRALEASVAQLAGQLKELSGHLPALSSRLD----- 418
EL RQ+ E L + E+ AL+AS + A EL L + S +
Sbjct: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098
Query: 419 --------LQEQMLGLRLSEAKTEWEGAERKSL---EDLARWRKEVTEHLRGVREKVD-- 465
+++ L + E E +KSL E+ AR RK E + ++ KV+
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 466 -GLPQQIESVSDKCL-LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPG 523
L ++ E S + L L + + R+ AE KA F V QEL L Q + + G
Sbjct: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2218
Query: 524 RKIAEMQGKLATFQNQIMKLENCVQANKTI---QNLRFNTEARLRTQEMATLWESVLRLW 580
A + + ++ Q+ + + + L+ + E + + + A LR
Sbjct: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278
Query: 581 SEE 583
+E+
Sbjct: 2279 AEQ 2281
Score = 73.9 bits (180), Expect = 4e-13
Identities = 127/542 (23%), Positives = 224/542 (41%), Gaps = 60/542 (11%)
Query: 58 ASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSE 117
A Q A+ + ++ +Q EV E ++ RS+ EL Q+R Q +E
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR---QSSEAE 1569
Query: 118 LRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGA 177
++ ++A A ++ + E ++ Q++A +++ L LR R + EA++R A
Sbjct: 1570 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1629
Query: 178 EQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVD-----LEVARMQAQVTKLG 232
++EA ++ D Q++ Q EV + K + +++R LE R+QA
Sbjct: 1630 QEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEELRLQA------ 1682
Query: 233 EEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEE 292
EE R + E + +Q +ALE +++E+ +L+ E + R L EE
Sbjct: 1683 EEAERRLRQAEVERARQVQ---VALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEE 1736
Query: 293 RLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVL--------LAEEKAW-D 343
+ Q + E +Q + A + + +++ Q N L +A++K+
Sbjct: 1737 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796
Query: 344 AKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL 403
A+ ++ A A + E A ELA QE+ EK R L AQ
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL--------EKQRQLAEGTAQQRLAA 1848
Query: 404 KELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREK 463
++ L A + + + Q Q+L L+ + E A +K R+E+ L VR +
Sbjct: 1849 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK--------RQELEAELAKVRAE 1900
Query: 464 VDGLPQQIESVSDKCLLHKSDSDLRISAE-GKAREFKVGALR-QELATLLSSVQLLKEDN 521
++ L ++ S R+ AE G+ RE A R + LA + L E++
Sbjct: 1901 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1960
Query: 522 PGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWS 581
R+ AE + LA KL +A R TEA + +E E + RL
Sbjct: 1961 AARQRAEAERVLAE------KLAAIGEAT------RLKTEAEIALKEKEAENERLRRLAE 2008
Query: 582 EE 583
+E
Sbjct: 2009 DE 2010
Score = 65.5 bits (158), Expect = 2e-10
Identities = 146/589 (24%), Positives = 236/589 (40%), Gaps = 97/589 (16%)
Query: 35 ASPEPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCE 94
A L+ EE R E+ + E++ A+ + V L+A+V R ++R E
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2166
Query: 95 RATRSLLRELLQVRARVQLQGSE------------------------LRQLQQEARPAAQ 130
+ + L +L Q A+ +LQ E L QL+ EA A +
Sbjct: 2167 QESARQL-QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2225
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALT------------------RLRRRQVQQEA 172
A E EA E + A +R VE E L +LR+ Q+ A
Sbjct: 2226 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2284
Query: 173 ERRGAEQEAGLRLAKLTDLLQQEEQ--GREVACGALQKNQEDSSRRVDLEVARMQAQVTK 230
R AEQ A LR + D ++ + + Q QE ++ R+ LE Q +
Sbjct: 2285 RRAQAEQ-AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-- 2341
Query: 231 LGEEVSLRFLKREAKLCGFLQKSFLALE---KRMKASESSRLKLEGSLRGELESRWEKLR 287
L EE L+ LK EA Q+S + E R++ E S+LK R E E+R LR
Sbjct: 2342 LDEE--LQRLKAEATEAA-RQRSQVEEELFSVRVQMEELSKLK----ARIEAENRALILR 2394
Query: 288 GLMEERLRALQGQHEE-SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKG 346
+ R LQ + E+ + E+ L A + + Q + LA+++A K
Sbjct: 2395 D-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEKM 2448
Query: 347 RLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL-KE 405
E+ +A + A ++ E Q ELA +E++R L+ Q+A QL +E
Sbjct: 2449 LKEKMQAVQEATRLKAEAELLQQQKELA-----------QEQARRLQEDKEQMAQQLAEE 2497
Query: 406 LSGHLPALSSRLDLQEQML--GLRLSEAKTEWEGAERKSLEDLARWRK---EVTEHLR-- 458
G L + Q +M RL E A+ ++ ED R+RK E+ E L
Sbjct: 2498 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2557
Query: 459 --GVREKVDGLP----QQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLS 512
+EKV + Q+ +S D L ++ ++L E +E K+ L+ E +
Sbjct: 2558 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2617
Query: 513 SVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTE 561
QLL+E +Q + ++ +++ E ++ K F E
Sbjct: 2618 QEQLLQETQ------ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2660
Score = 36.6 bits (83), Expect = 0.077
Identities = 52/188 (27%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 34 LASPEPLSLEELSE--RYESSHPTSTA--SVPEQDTAKHWNQLEQWVVELQAEVACLREH 89
LA+ E ++L + E R +S H ++ E + K Q E +++L++E +
Sbjct: 2559 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2618
Query: 90 KQRCERAT---RSLLRE---LLQVRARVQLQGSELRQL-QQEARPAAQAPEKEAPEFSGL 142
+Q + +S L E LLQ ++ + ++L QL Q E A Q E++ +
Sbjct: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ---- 2674
Query: 143 QNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVA 202
Q QM+ +RLV E EA RR E E G+R K +L Q E+Q R+
Sbjct: 2675 QQQMEQERQRLVASME------------EARRRQHEAEEGVR-RKQEELQQLEQQRRQQE 2721
Query: 203 CGALQKNQ 210
++NQ
Sbjct: 2722 ELLAEENQ 2729
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 85.5 bits (210), Expect = 1e-16
Identities = 150/603 (24%), Positives = 250/603 (41%), Gaps = 82/603 (13%)
Query: 40 LSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQR------- 92
++LE E+ + AS E+ QLE+ + E VA LRE +R
Sbjct: 1543 VALETAQRSAEAELQSKRASFAEKTA-----QLERSLQEEHVAVAQLREEAERRAQQQAE 1597
Query: 93 CERATRSLLREL--LQVRA----RVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQM 146
ERA REL Q++A R++LQ E+ Q + A+ A+ ++EA + + +
Sbjct: 1598 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1657
Query: 147 QALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL 206
+ R E+ E +R+ + A++R A ++ +RL T+ +Q+ Q E L
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717
Query: 207 QKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASES 266
Q R A T+ +E+ K A++ L A E+ SE
Sbjct: 1718 Q---------------REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1762
Query: 267 SRLKLE---GSLRGELESRWEKLRGLMEERLR---------ALQGQHEESHLLEQCQGLD 314
S+ +LE G R EL +LR L EE R A Q E L E+ +
Sbjct: 1763 SKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821
Query: 315 AAVAQLTK---FVQQNQASLNRV-LLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLA 370
A T+ +++ +A R+ LAE++A+ + RLEE +A + A ++E L + A
Sbjct: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR-RLEE-QAAQHKADIEERLAQLRKA 1879
Query: 371 --GELARQEMHGELVL-----LREKSRALEASVAQLAGQLKELSGHLPALSSRLD----- 418
EL RQ+ E L + E+ AL+AS + A EL L + S +
Sbjct: 1880 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939
Query: 419 --------LQEQMLGLRLSEAKTEWEGAERKSL---EDLARWRKEVTEHLRGVREKVD-- 465
+++ L + E E +KSL E+ AR RK E + ++ KV+
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Query: 466 -GLPQQIESVSDKCL-LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPG 523
L ++ E S + L L + + R+ AE KA F V QEL L Q + + G
Sbjct: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2059
Query: 524 RKIAEMQGKLATFQNQIMKLENCVQANKTI---QNLRFNTEARLRTQEMATLWESVLRLW 580
A + + ++ Q+ + + + L+ + E + + + A LR
Sbjct: 2060 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2119
Query: 581 SEE 583
+E+
Sbjct: 2120 AEQ 2122
Score = 73.9 bits (180), Expect = 4e-13
Identities = 127/542 (23%), Positives = 224/542 (41%), Gaps = 60/542 (11%)
Query: 58 ASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSE 117
A Q A+ + ++ +Q EV E ++ RS+ EL Q+R Q +E
Sbjct: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR---QSSEAE 1410
Query: 118 LRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGA 177
++ ++A A ++ + E ++ Q++A +++ L LR R + EA++R A
Sbjct: 1411 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1470
Query: 178 EQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVD-----LEVARMQAQVTKLG 232
++EA ++ D Q++ Q EV + K + +++R LE R+QA
Sbjct: 1471 QEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEELRLQA------ 1523
Query: 233 EEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEE 292
EE R + E + +Q +ALE +++E+ +L+ E + R L EE
Sbjct: 1524 EEAERRLRQAEVERARQVQ---VALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEE 1577
Query: 293 RLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVL--------LAEEKAW-D 343
+ Q + E +Q + A + + +++ Q N L +A++K+
Sbjct: 1578 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637
Query: 344 AKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL 403
A+ ++ A A + E A ELA QE+ EK R L AQ
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL--------EKQRQLAEGTAQQRLAA 1689
Query: 404 KELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREK 463
++ L A + + + Q Q+L L+ + E A +K R+E+ L VR +
Sbjct: 1690 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK--------RQELEAELAKVRAE 1741
Query: 464 VDGLPQQIESVSDKCLLHKSDSDLRISAE-GKAREFKVGALR-QELATLLSSVQLLKEDN 521
++ L ++ S R+ AE G+ RE A R + LA + L E++
Sbjct: 1742 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1801
Query: 522 PGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWS 581
R+ AE + LA KL +A R TEA + +E E + RL
Sbjct: 1802 AARQRAEAERVLAE------KLAAIGEAT------RLKTEAEIALKEKEAENERLRRLAE 1849
Query: 582 EE 583
+E
Sbjct: 1850 DE 1851
Score = 65.5 bits (158), Expect = 2e-10
Identities = 146/589 (24%), Positives = 236/589 (40%), Gaps = 97/589 (16%)
Query: 35 ASPEPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCE 94
A L+ EE R E+ + E++ A+ + V L+A+V R ++R E
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2007
Query: 95 RATRSLLRELLQVRARVQLQGSE------------------------LRQLQQEARPAAQ 130
+ + L +L Q A+ +LQ E L QL+ EA A +
Sbjct: 2008 QESARQL-QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2066
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALT------------------RLRRRQVQQEA 172
A E EA E + A +R VE E L +LR+ Q+ A
Sbjct: 2067 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2125
Query: 173 ERRGAEQEAGLRLAKLTDLLQQEEQ--GREVACGALQKNQEDSSRRVDLEVARMQAQVTK 230
R AEQ A LR + D ++ + + Q QE ++ R+ LE Q +
Sbjct: 2126 RRAQAEQ-AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-- 2182
Query: 231 LGEEVSLRFLKREAKLCGFLQKSFLALE---KRMKASESSRLKLEGSLRGELESRWEKLR 287
L EE L+ LK EA Q+S + E R++ E S+LK R E E+R LR
Sbjct: 2183 LDEE--LQRLKAEATEAA-RQRSQVEEELFSVRVQMEELSKLK----ARIEAENRALILR 2235
Query: 288 GLMEERLRALQGQHEE-SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKG 346
+ R LQ + E+ + E+ L A + + Q + LA+++A K
Sbjct: 2236 D-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEKM 2289
Query: 347 RLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL-KE 405
E+ +A + A ++ E Q ELA +E++R L+ Q+A QL +E
Sbjct: 2290 LKEKMQAVQEATRLKAEAELLQQQKELA-----------QEQARRLQEDKEQMAQQLAEE 2338
Query: 406 LSGHLPALSSRLDLQEQML--GLRLSEAKTEWEGAERKSLEDLARWRK---EVTEHLR-- 458
G L + Q +M RL E A+ ++ ED R+RK E+ E L
Sbjct: 2339 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2398
Query: 459 --GVREKVDGLP----QQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLS 512
+EKV + Q+ +S D L ++ ++L E +E K+ L+ E +
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2458
Query: 513 SVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTE 561
QLL+E +Q + ++ +++ E ++ K F E
Sbjct: 2459 QEQLLQETQ------ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2501
Score = 36.6 bits (83), Expect = 0.077
Identities = 52/188 (27%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 34 LASPEPLSLEELSE--RYESSHPTSTA--SVPEQDTAKHWNQLEQWVVELQAEVACLREH 89
LA+ E ++L + E R +S H ++ E + K Q E +++L++E +
Sbjct: 2400 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2459
Query: 90 KQRCERAT---RSLLRE---LLQVRARVQLQGSELRQL-QQEARPAAQAPEKEAPEFSGL 142
+Q + +S L E LLQ ++ + ++L QL Q E A Q E++ +
Sbjct: 2460 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ---- 2515
Query: 143 QNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVA 202
Q QM+ +RLV E EA RR E E G+R K +L Q E+Q R+
Sbjct: 2516 QQQMEQERQRLVASME------------EARRRQHEAEEGVR-RKQEELQQLEQQRRQQE 2562
Query: 203 CGALQKNQ 210
++NQ
Sbjct: 2563 ELLAEENQ 2570
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 85.5 bits (210), Expect = 1e-16
Identities = 150/603 (24%), Positives = 250/603 (41%), Gaps = 82/603 (13%)
Query: 40 LSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQR------- 92
++LE E+ + AS E+ QLE+ + E VA LRE +R
Sbjct: 1551 VALETAQRSAEAELQSKRASFAEKTA-----QLERSLQEEHVAVAQLREEAERRAQQQAE 1605
Query: 93 CERATRSLLREL--LQVRA----RVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQM 146
ERA REL Q++A R++LQ E+ Q + A+ A+ ++EA + + +
Sbjct: 1606 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1665
Query: 147 QALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL 206
+ R E+ E +R+ + A++R A ++ +RL T+ +Q+ Q E L
Sbjct: 1666 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1725
Query: 207 QKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASES 266
Q R A T+ +E+ K A++ L A E+ SE
Sbjct: 1726 Q---------------REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1770
Query: 267 SRLKLE---GSLRGELESRWEKLRGLMEERLR---------ALQGQHEESHLLEQCQGLD 314
S+ +LE G R EL +LR L EE R A Q E L E+ +
Sbjct: 1771 SKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1829
Query: 315 AAVAQLTK---FVQQNQASLNRV-LLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLA 370
A T+ +++ +A R+ LAE++A+ + RLEE +A + A ++E L + A
Sbjct: 1830 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR-RLEE-QAAQHKADIEERLAQLRKA 1887
Query: 371 --GELARQEMHGELVL-----LREKSRALEASVAQLAGQLKELSGHLPALSSRLD----- 418
EL RQ+ E L + E+ AL+AS + A EL L + S +
Sbjct: 1888 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947
Query: 419 --------LQEQMLGLRLSEAKTEWEGAERKSL---EDLARWRKEVTEHLRGVREKVD-- 465
+++ L + E E +KSL E+ AR RK E + ++ KV+
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Query: 466 -GLPQQIESVSDKCL-LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPG 523
L ++ E S + L L + + R+ AE KA F V QEL L Q + + G
Sbjct: 2008 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2067
Query: 524 RKIAEMQGKLATFQNQIMKLENCVQANKTI---QNLRFNTEARLRTQEMATLWESVLRLW 580
A + + ++ Q+ + + + L+ + E + + + A LR
Sbjct: 2068 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2127
Query: 581 SEE 583
+E+
Sbjct: 2128 AEQ 2130
Score = 73.9 bits (180), Expect = 4e-13
Identities = 127/542 (23%), Positives = 224/542 (41%), Gaps = 60/542 (11%)
Query: 58 ASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSE 117
A Q A+ + ++ +Q EV E ++ RS+ EL Q+R Q +E
Sbjct: 1362 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR---QSSEAE 1418
Query: 118 LRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGA 177
++ ++A A ++ + E ++ Q++A +++ L LR R + EA++R A
Sbjct: 1419 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1478
Query: 178 EQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVD-----LEVARMQAQVTKLG 232
++EA ++ D Q++ Q EV + K + +++R LE R+QA
Sbjct: 1479 QEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEELRLQA------ 1531
Query: 233 EEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEE 292
EE R + E + +Q +ALE +++E+ +L+ E + R L EE
Sbjct: 1532 EEAERRLRQAEVERARQVQ---VALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEE 1585
Query: 293 RLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVL--------LAEEKAW-D 343
+ Q + E +Q + A + + +++ Q N L +A++K+
Sbjct: 1586 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1645
Query: 344 AKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL 403
A+ ++ A A + E A ELA QE+ EK R L AQ
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL--------EKQRQLAEGTAQQRLAA 1697
Query: 404 KELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREK 463
++ L A + + + Q Q+L L+ + E A +K R+E+ L VR +
Sbjct: 1698 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK--------RQELEAELAKVRAE 1749
Query: 464 VDGLPQQIESVSDKCLLHKSDSDLRISAE-GKAREFKVGALR-QELATLLSSVQLLKEDN 521
++ L ++ S R+ AE G+ RE A R + LA + L E++
Sbjct: 1750 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1809
Query: 522 PGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWS 581
R+ AE + LA KL +A R TEA + +E E + RL
Sbjct: 1810 AARQRAEAERVLAE------KLAAIGEAT------RLKTEAEIALKEKEAENERLRRLAE 1857
Query: 582 EE 583
+E
Sbjct: 1858 DE 1859
Score = 65.5 bits (158), Expect = 2e-10
Identities = 146/589 (24%), Positives = 236/589 (40%), Gaps = 97/589 (16%)
Query: 35 ASPEPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCE 94
A L+ EE R E+ + E++ A+ + V L+A+V R ++R E
Sbjct: 1956 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2015
Query: 95 RATRSLLRELLQVRARVQLQGSE------------------------LRQLQQEARPAAQ 130
+ + L +L Q A+ +LQ E L QL+ EA A +
Sbjct: 2016 QESARQL-QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2074
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALT------------------RLRRRQVQQEA 172
A E EA E + A +R VE E L +LR+ Q+ A
Sbjct: 2075 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2133
Query: 173 ERRGAEQEAGLRLAKLTDLLQQEEQ--GREVACGALQKNQEDSSRRVDLEVARMQAQVTK 230
R AEQ A LR + D ++ + + Q QE ++ R+ LE Q +
Sbjct: 2134 RRAQAEQ-AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-- 2190
Query: 231 LGEEVSLRFLKREAKLCGFLQKSFLALE---KRMKASESSRLKLEGSLRGELESRWEKLR 287
L EE L+ LK EA Q+S + E R++ E S+LK R E E+R LR
Sbjct: 2191 LDEE--LQRLKAEATEAA-RQRSQVEEELFSVRVQMEELSKLK----ARIEAENRALILR 2243
Query: 288 GLMEERLRALQGQHEE-SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKG 346
+ R LQ + E+ + E+ L A + + Q + LA+++A K
Sbjct: 2244 D-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEKM 2297
Query: 347 RLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL-KE 405
E+ +A + A ++ E Q ELA +E++R L+ Q+A QL +E
Sbjct: 2298 LKEKMQAVQEATRLKAEAELLQQQKELA-----------QEQARRLQEDKEQMAQQLAEE 2346
Query: 406 LSGHLPALSSRLDLQEQML--GLRLSEAKTEWEGAERKSLEDLARWRK---EVTEHLR-- 458
G L + Q +M RL E A+ ++ ED R+RK E+ E L
Sbjct: 2347 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2406
Query: 459 --GVREKVDGLP----QQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLS 512
+EKV + Q+ +S D L ++ ++L E +E K+ L+ E +
Sbjct: 2407 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2466
Query: 513 SVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTE 561
QLL+E +Q + ++ +++ E ++ K F E
Sbjct: 2467 QEQLLQETQ------ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2509
Score = 36.6 bits (83), Expect = 0.077
Identities = 52/188 (27%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 34 LASPEPLSLEELSE--RYESSHPTSTA--SVPEQDTAKHWNQLEQWVVELQAEVACLREH 89
LA+ E ++L + E R +S H ++ E + K Q E +++L++E +
Sbjct: 2408 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2467
Query: 90 KQRCERAT---RSLLRE---LLQVRARVQLQGSELRQL-QQEARPAAQAPEKEAPEFSGL 142
+Q + +S L E LLQ ++ + ++L QL Q E A Q E++ +
Sbjct: 2468 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ---- 2523
Query: 143 QNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVA 202
Q QM+ +RLV E EA RR E E G+R K +L Q E+Q R+
Sbjct: 2524 QQQMEQERQRLVASME------------EARRRQHEAEEGVR-RKQEELQQLEQQRRQQE 2570
Query: 203 CGALQKNQ 210
++NQ
Sbjct: 2571 ELLAEENQ 2578
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 85.5 bits (210), Expect = 1e-16
Identities = 150/603 (24%), Positives = 250/603 (41%), Gaps = 82/603 (13%)
Query: 40 LSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQR------- 92
++LE E+ + AS E+ QLE+ + E VA LRE +R
Sbjct: 1592 VALETAQRSAEAELQSKRASFAEKTA-----QLERSLQEEHVAVAQLREEAERRAQQQAE 1646
Query: 93 CERATRSLLREL--LQVRA----RVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQM 146
ERA REL Q++A R++LQ E+ Q + A+ A+ ++EA + + +
Sbjct: 1647 AERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA 1706
Query: 147 QALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL 206
+ R E+ E +R+ + A++R A ++ +RL T+ +Q+ Q E L
Sbjct: 1707 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1766
Query: 207 QKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASES 266
Q R A T+ +E+ K A++ L A E+ SE
Sbjct: 1767 Q---------------REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1811
Query: 267 SRLKLE---GSLRGELESRWEKLRGLMEERLR---------ALQGQHEESHLLEQCQGLD 314
S+ +LE G R EL +LR L EE R A Q E L E+ +
Sbjct: 1812 SKQRLEAEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870
Query: 315 AAVAQLTK---FVQQNQASLNRV-LLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLA 370
A T+ +++ +A R+ LAE++A+ + RLEE +A + A ++E L + A
Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR-RLEE-QAAQHKADIEERLAQLRKA 1928
Query: 371 --GELARQEMHGELVL-----LREKSRALEASVAQLAGQLKELSGHLPALSSRLD----- 418
EL RQ+ E L + E+ AL+AS + A EL L + S +
Sbjct: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988
Query: 419 --------LQEQMLGLRLSEAKTEWEGAERKSL---EDLARWRKEVTEHLRGVREKVD-- 465
+++ L + E E +KSL E+ AR RK E + ++ KV+
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
Query: 466 -GLPQQIESVSDKCL-LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPG 523
L ++ E S + L L + + R+ AE KA F V QEL L Q + + G
Sbjct: 2049 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2108
Query: 524 RKIAEMQGKLATFQNQIMKLENCVQANKTI---QNLRFNTEARLRTQEMATLWESVLRLW 580
A + + ++ Q+ + + + L+ + E + + + A LR
Sbjct: 2109 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2168
Query: 581 SEE 583
+E+
Sbjct: 2169 AEQ 2171
Score = 73.9 bits (180), Expect = 4e-13
Identities = 127/542 (23%), Positives = 224/542 (41%), Gaps = 60/542 (11%)
Query: 58 ASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSE 117
A Q A+ + ++ +Q EV E ++ RS+ EL Q+R Q +E
Sbjct: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR---QSSEAE 1459
Query: 118 LRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGA 177
++ ++A A ++ + E ++ Q++A +++ L LR R + EA++R A
Sbjct: 1460 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1519
Query: 178 EQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVD-----LEVARMQAQVTKLG 232
++EA ++ D Q++ Q EV + K + +++R LE R+QA
Sbjct: 1520 QEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRALQALEELRLQA------ 1572
Query: 233 EEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEE 292
EE R + E + +Q +ALE +++E+ +L+ E + R L EE
Sbjct: 1573 EEAERRLRQAEVERARQVQ---VALETAQRSAEA---ELQSKRASFAEKTAQLERSLQEE 1626
Query: 293 RLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVL--------LAEEKAW-D 343
+ Q + E +Q + A + + +++ Q N L +A++K+
Sbjct: 1627 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686
Query: 344 AKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL 403
A+ ++ A A + E A ELA QE+ EK R L AQ
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL--------EKQRQLAEGTAQQRLAA 1738
Query: 404 KELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREK 463
++ L A + + + Q Q+L L+ + E A +K R+E+ L VR +
Sbjct: 1739 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK--------RQELEAELAKVRAE 1790
Query: 464 VDGLPQQIESVSDKCLLHKSDSDLRISAE-GKAREFKVGALR-QELATLLSSVQLLKEDN 521
++ L ++ S R+ AE G+ RE A R + LA + L E++
Sbjct: 1791 MEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1850
Query: 522 PGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWS 581
R+ AE + LA KL +A R TEA + +E E + RL
Sbjct: 1851 AARQRAEAERVLAE------KLAAIGEAT------RLKTEAEIALKEKEAENERLRRLAE 1898
Query: 582 EE 583
+E
Sbjct: 1899 DE 1900
Score = 65.5 bits (158), Expect = 2e-10
Identities = 146/589 (24%), Positives = 236/589 (40%), Gaps = 97/589 (16%)
Query: 35 ASPEPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCE 94
A L+ EE R E+ + E++ A+ + V L+A+V R ++R E
Sbjct: 1997 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2056
Query: 95 RATRSLLRELLQVRARVQLQGSE------------------------LRQLQQEARPAAQ 130
+ + L +L Q A+ +LQ E L QL+ EA A +
Sbjct: 2057 QESARQL-QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARR 2115
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALT------------------RLRRRQVQQEA 172
A E EA E + A +R VE E L +LR+ Q+ A
Sbjct: 2116 AAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA 2174
Query: 173 ERRGAEQEAGLRLAKLTDLLQQEEQ--GREVACGALQKNQEDSSRRVDLEVARMQAQVTK 230
R AEQ A LR + D ++ + + Q QE ++ R+ LE Q +
Sbjct: 2175 RRAQAEQ-AALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL-- 2231
Query: 231 LGEEVSLRFLKREAKLCGFLQKSFLALE---KRMKASESSRLKLEGSLRGELESRWEKLR 287
L EE L+ LK EA Q+S + E R++ E S+LK R E E+R LR
Sbjct: 2232 LDEE--LQRLKAEATEAA-RQRSQVEEELFSVRVQMEELSKLK----ARIEAENRALILR 2284
Query: 288 GLMEERLRALQGQHEE-SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKG 346
+ R LQ + E+ + E+ L A + + Q + LA+++A K
Sbjct: 2285 D-KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED-----LAQQRALAEKM 2338
Query: 347 RLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL-KE 405
E+ +A + A ++ E Q ELA +E++R L+ Q+A QL +E
Sbjct: 2339 LKEKMQAVQEATRLKAEAELLQQQKELA-----------QEQARRLQEDKEQMAQQLAEE 2387
Query: 406 LSGHLPALSSRLDLQEQML--GLRLSEAKTEWEGAERKSLEDLARWRK---EVTEHLR-- 458
G L + Q +M RL E A+ ++ ED R+RK E+ E L
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2447
Query: 459 --GVREKVDGLP----QQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLS 512
+EKV + Q+ +S D L ++ ++L E +E K+ L+ E +
Sbjct: 2448 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2507
Query: 513 SVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTE 561
QLL+E +Q + ++ +++ E ++ K F E
Sbjct: 2508 QEQLLQETQ------ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2550
Score = 36.6 bits (83), Expect = 0.077
Identities = 52/188 (27%), Positives = 85/188 (45%), Gaps = 28/188 (14%)
Query: 34 LASPEPLSLEELSE--RYESSHPTSTA--SVPEQDTAKHWNQLEQWVVELQAEVACLREH 89
LA+ E ++L + E R +S H ++ E + K Q E +++L++E +
Sbjct: 2449 LATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2508
Query: 90 KQRCERAT---RSLLRE---LLQVRARVQLQGSELRQL-QQEARPAAQAPEKEAPEFSGL 142
+Q + +S L E LLQ ++ + ++L QL Q E A Q E++ +
Sbjct: 2509 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQ---- 2564
Query: 143 QNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVA 202
Q QM+ +RLV E EA RR E E G+R K +L Q E+Q R+
Sbjct: 2565 QQQMEQERQRLVASME------------EARRRQHEAEEGVR-RKQEELQQLEQQRRQQE 2611
Query: 203 CGALQKNQ 210
++NQ
Sbjct: 2612 ELLAEENQ 2619
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 84.0 bits (206), Expect = 4e-16
Identities = 163/649 (25%), Positives = 263/649 (40%), Gaps = 94/649 (14%)
Query: 4 LADSGPSGASAPSQLRAVTLEDL-----GLLLAGGLASPEPLSLEELSERYESSHPTSTA 58
L GP PS+ +V LE+ GL LA G A E +R E +
Sbjct: 641 LRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAR-----EHDQRLEGTVRDPAW 695
Query: 59 SVPEQDTAKHWNQLEQWVVELQ--------AEVACLREHKQRCERATRSLLRELLQVRAR 110
P+Q + +++ W + AE LRE + R +L EL +
Sbjct: 696 QKPQQKSEGAL-EVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARK 754
Query: 111 VQLQGSELRQLQQEARPAAQAP-------EKEAPEFSGLQNQMQALDKRLVEV---REAL 160
++ Q +E +L +E A +A E +A E + L+ ++A + L REAL
Sbjct: 755 LEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREAL 814
Query: 161 TRL------RRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSS 214
RRQ ++E R A+ EA ++ E +GR+ A ++ +E +
Sbjct: 815 VEALAAAGRERRQWEREGSRLRAQSEAAEERMQVL-----ESEGRQHLEEAERERREKEA 869
Query: 215 RRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLK-LEG 273
+ +LE A ++ + +LG L L+RE + ++ FL R K S+ R + LE
Sbjct: 870 LQAELEKAVVRGK--ELG--ARLEHLQRELEQAALERQEFL----REKESQHQRYQGLEQ 921
Query: 274 SLRGELE-SRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASL- 331
L EL+ + K LME + RALQ + E L + GL + V+ L
Sbjct: 922 RLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLI 981
Query: 332 -----NRVLLAEEKAWDAKGRLEESRAGELAAYVQE-------------NLEAAQLAGEL 373
N +L+AE+ A + + E + G L QE L+A + E+
Sbjct: 982 EVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEI 1041
Query: 374 ARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKT 433
QE+H +L +L E+ RA S + GQ + L AL+ LQ R EA+
Sbjct: 1042 QGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALA---QLQ------RRQEAEL 1092
Query: 434 EWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEG 493
E + L+ R + L+G E++ +E+ L + R+ +G
Sbjct: 1093 EGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERE----RLMQDG 1148
Query: 494 KAREFKVGALRQELATLLSS---VQLLKEDNPGRKIAEMQGKLATFQNQIMKLE-NCVQA 549
+ L +EL L S Q+L + R+ E+QG+ + ++ +LE Q
Sbjct: 1149 HRQR----GLEEELRRLQSEHDRAQMLLAE-LSRERGELQGERGELRGRLARLELERAQL 1203
Query: 550 NKTIQNLR-FNTEARLRTQEMATLWESVLRLWS--EEGPRTPLGSWKAL 595
Q LR N + L + T E + +L S EE R L +AL
Sbjct: 1204 EMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQAL 1252
Score = 58.9 bits (141), Expect = 1e-08
Identities = 94/399 (23%), Positives = 160/399 (40%), Gaps = 61/399 (15%)
Query: 94 ERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEA-PEFSGLQNQMQALDKR 152
+ A S L++++ R EL QL+Q PA P+K A P+ QN R
Sbjct: 928 QAAATSKEEALMELKTRALQLEEELFQLRQG--PAGLGPKKRAEPQLVETQNV------R 979
Query: 153 LVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQED 212
L+EV + L + + + + E + G + +LL Q ++ +E
Sbjct: 980 LIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQE------------ 1027
Query: 213 SSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLE 272
S R+ E + ++ Q +L + L L+ E + Q+ ++ + + +L+
Sbjct: 1028 HSSRLQAEKSVLEIQGQELHRK--LEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQ 1085
Query: 273 GSLRGELESRWEKLRGL------MEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQ 326
ELE + R L +E R LQG+HE+ +Q
Sbjct: 1086 RRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQ--------------------LQA 1125
Query: 327 NQASLNR---VLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQ--EMHGE 381
+AS+ LLAE + G + EL E+ A L EL+R+ E+ GE
Sbjct: 1126 QRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGE 1185
Query: 382 LVLLREKSRALEASVAQL---AGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGA 438
LR + LE AQL + QL+E + L + RL Q ++ L++ ++ E
Sbjct: 1186 RGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCEL----LTQLRSAQEEE 1241
Query: 439 ERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDK 477
R+ L ++ +E E L E D L ++ D+
Sbjct: 1242 NRQLLAEVQALSRENRELLERSLESRDHLHREQREYLDQ 1280
Score = 53.5 bits (127), Expect = 6e-07
Identities = 94/349 (26%), Positives = 145/349 (41%), Gaps = 56/349 (16%)
Query: 4 LADSGPS-GASAPSQLRAVTLEDLGLLLAGGLASPEPLSLEELSERYESSHPT-----ST 57
LA SGP G AP++L ++ +G L LA L + L+E P +
Sbjct: 187 LALSGPDPGELAPAELEMLSRSLMGTL--SKLARERDLGAQRLAELLLEREPLCLRPEAP 244
Query: 58 ASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSE 117
+ P + + H ++L A LR +Q E LL +A VQ +E
Sbjct: 245 SRAPAEGPSHHL------ALQLANAKAQLRRLRQELEEKAELLLDS----QAEVQGLEAE 294
Query: 118 LRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGA 177
+R+L+QEA+ A K A + ++ RL ++E L R R R EA +
Sbjct: 295 IRRLRQEAQ-ALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQL 353
Query: 178 EQE---AGLRLAKLTDLLQQEEQGREVACGALQKNQEDS------SRRVDLEVARMQAQV 228
E+E +G+ A L +Q E RE C L + Q ++ E+ ++ QV
Sbjct: 354 EEERVLSGVLEASKALLEEQLEAARE-RCARLHETQRENLLLRTRLGEAHAELDSLRHQV 412
Query: 229 TKLGEE-VSLRF-LKR----------EAKLCGFLQKSFLALEKRMKASESSRLKLEGSLR 276
+L EE V L L+R EA L G + +L+ ++ +E+ RL+
Sbjct: 413 DQLAEENVELELELQRSLEPPPGSPGEAPLAG----AAPSLQDEVREAEAGRLR------ 462
Query: 277 GELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQ 325
LE +LRGL L+ LQGQ H L + D + L + Q
Sbjct: 463 -TLERENRELRGL----LQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQ 506
Score = 46.2 bits (108), Expect = 1e-04
Identities = 73/327 (22%), Positives = 117/327 (35%), Gaps = 67/327 (20%)
Query: 79 LQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPE 138
LQAE + L Q R L E+ R + + + L ++ + AQ ++ E
Sbjct: 1032 LQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEAE 1091
Query: 139 FSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQG 198
GL + + L + + A L+ R Q +A+R E + LA+ L+Q
Sbjct: 1092 LEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQD---- 1147
Query: 199 REVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALE 258
G Q+ E+ RR+ E R Q + +L E
Sbjct: 1148 -----GHRQRGLEEELRRLQSEHDRAQMLLAELSRE------------------------ 1178
Query: 259 KRMKASESSRLKLEGSLRGELESRWEKLRG-LMEERLRALQGQHEESHLLEQCQGLDAAV 317
RGEL+ +LRG L L Q + + L E Q LD +
Sbjct: 1179 -----------------RGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSA 1221
Query: 318 AQLT------KFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAG 371
+LT ++ Q NR LLAE +A + R ++ +LE+
Sbjct: 1222 CRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENR----------ELLERSLESRDHLH 1271
Query: 372 ELARQEMHGELVLLREKSRALEASVAQ 398
R+ + L REK + +E + Q
Sbjct: 1272 REQREYLDQLNALRREKQKLVEKIMDQ 1298
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 80.1 bits (196), Expect = 6e-15
Identities = 128/576 (22%), Positives = 235/576 (40%), Gaps = 59/576 (10%)
Query: 43 EELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLR 102
EE+ + ST ++ D+ K + + + V L E K+R ++ +L +
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKK-------LQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 103 ELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTR 162
+ + A +LQQE + + S L+ + + D+ L E + ++
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 163 LRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQED---------- 212
+ + EAE R E +A L LA+ + + ++ E L+ ED
Sbjct: 1467 YADERDRAEAEAREKETKA-LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525
Query: 213 -------SSRRVDLEVARMQAQVTKLGEEVSLRF---LKREAKLCGFLQKSFLALEKRMK 262
S R ++ ++ M+ Q+ +L +E+ L+ E + + L+ R +
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 263 ASESSRLKLEGSLRGELESRWE---KLRGLMEERLRALQGQHEESHLLEQC--QGLDAAV 317
+E R +L+ L E E+ E K R L + L+G ++ L +G + A+
Sbjct: 1586 QNEEKRRQLQRQLH-EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 318 AQLTKFVQQNQASLNRVLLAEEKAWD---AKGRLEESRAGELAA---YVQENLEAAQLA- 370
QL K +Q R L + D A + E +A L A +QE+L AA+ A
Sbjct: 1645 KQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703
Query: 371 --GELARQEMHGELV-------LLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQE 421
+L ++E+ EL L+++ R LEA +AQL +L+E G++ A+S R+
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 422 QMLGLRLSEAKTEWEGAER--KSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCL 479
Q +E TE A++ + + L R KE+ L E + + +S
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL---HEMEGAVKSKFKSTIAALE 1820
Query: 480 LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQ 539
+ + ++ E + ++ +L+Q+ L + L ED RK+AE + A N
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQK-DKKLKEILLQVEDE--RKMAEQYKEQAEKGNA 1877
Query: 540 IMKLENCVQANKTIQNLRFNTEARLRTQEMATLWES 575
+K ++ R N R +E+ ES
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Score = 62.0 bits (149), Expect = 2e-09
Identities = 141/585 (24%), Positives = 249/585 (42%), Gaps = 129/585 (22%)
Query: 101 LRELLQV-RARVQLQGSELRQLQQEARPAAQAPEKEAPEFSG-----------LQNQMQA 148
++ LLQV R ++Q E Q+ + Q E E E LQ Q+QA
Sbjct: 841 VKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 149 LDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL-- 206
+ E E RL + +QE E E EA RL + D QQ + R+ +
Sbjct: 899 ETELYAEAEEMRVRLAAK--KQELEEILHEMEA--RLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 207 ---QKNQEDSSR-RVDLEVARMQAQVTKLGEEVSL-----RFLKREAKLCGFLQKSFLAL 257
Q +E+++R ++ LE +A++ KL +E+ + L +E KL L++ L
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEERISDL 1011
Query: 258 -----EKRMKASESSRLK-LEGSLRGELESRW---EKLRGLMEERLRALQGQHEESH--- 305
E+ KA ++LK S+ ELE R EK R +E+ R L+G + H
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 306 -------------LLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESR 352
L ++ + L AA+A+L + Q +L ++ E D + L+ R
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 353 AGELAAYVQ-----ENLEAAQ------LAGELARQEMHG----ELVLLR----EKSRALE 393
A A Q E LEA + L +QE+ E+ +L+ E++R+ E
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 394 ASV-------AQLAGQLKELSGHLPALSSRLDLQEQMLGLR----------LSEAKTEWE 436
A V AQ +L E + LD +Q L L +AK E E
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 437 GAERKSLEDLARWRKEVTEHLRG---VREKVDGLPQQIESVSDKCLLHKSDSDLRISAEG 493
++K + + + ++ R + +KV L ++ESV + + AEG
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----------TGMLNEAEG 1301
Query: 494 KAREFKVGALRQELATLLSSVQ----LLKED-----NPGRKIAEMQGKLATFQNQI---M 541
KA + L +++A+L S +Q LL+E+ N K+ +++ + + Q+Q+ M
Sbjct: 1302 KAIK-----LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 542 KLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPR 586
+ + ++ + + N++ ++++ + Q+ A+ E++ EEG +
Sbjct: 1357 EAKQNLERHISTLNIQL-SDSKKKLQDFASTVEAL-----EEGKK 1395
Score = 57.8 bits (138), Expect = 3e-08
Identities = 107/515 (20%), Positives = 221/515 (42%), Gaps = 51/515 (9%)
Query: 62 EQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQ------LQG 115
+ + K +LE + +LQ ++ R + + E+ R L EL ++ ++
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 116 SELR-QLQQEARPAAQAPEKEAPEFSG-LQNQMQALDKRLVEVREALTRLRRRQV----- 168
ELR + +QE +A ++E +Q Q + + E+ E L + +R +
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 169 QQEAERRGAEQEAGLR-LAKLTDLLQQEEQGREVACGALQKNQEDSSR-RVDL--EVARM 224
+Q E+ A+ LR L + ++ +++ E LQ D R R +L +V ++
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 225 QAQVTKL------GEEVSLRFLKREAKLCGFLQ--KSFLALEKRMKASESSRLKL----E 272
Q +V + E +++ K A L LQ + L E R K + S++L+
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 273 GSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLN 332
SL+ +L+ E + L E + L Q +S ++ Q + V L + ++ Q +
Sbjct: 1346 NSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSK--KKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 333 RVLLAEEKAWDAKGRLEESR---AGELAAYVQENLEAAQLAGELARQEMHGELVLLREKS 389
+ E+ A +LE+++ EL V + QL L +++ + +L EK+
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 390 RALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAE---RKSLEDL 446
+ + + + + + ALS L+E + EAK E E + +EDL
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEAL------EAKEELERTNKMLKAEMEDL 1516
Query: 447 ARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAR-EFKVGALRQ 505
+ +V +++ + + L Q+E + K L + + +L+ + + K R E + AL+
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 506 ELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQI 540
+ L + +++ K ++Q +L ++ ++
Sbjct: 1575 QFERDLQA----RDEQNEEKRRQLQRQLHEYETEL 1605
Score = 32.7 bits (73), Expect = 1.1
Identities = 23/109 (21%), Positives = 55/109 (50%), Gaps = 8/109 (7%)
Query: 42 LEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERAT---R 98
LEE E+ +T S+ ++D +L++ +++++ E ++K++ E+ +
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKD-----KKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 99 SLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQ 147
L R+L + Q + R+LQ+E A ++ E E + L+++++
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 80.1 bits (196), Expect = 6e-15
Identities = 128/576 (22%), Positives = 235/576 (40%), Gaps = 59/576 (10%)
Query: 43 EELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLR 102
EE+ + ST ++ D+ K + + + V L E K+R ++ +L +
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKK-------LQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 103 ELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTR 162
+ + A +LQQE + + S L+ + + D+ L E + ++
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 163 LRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQED---------- 212
+ + EAE R E +A L LA+ + + ++ E L+ ED
Sbjct: 1474 YADERDRAEAEAREKETKA-LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1532
Query: 213 -------SSRRVDLEVARMQAQVTKLGEEVSLRF---LKREAKLCGFLQKSFLALEKRMK 262
S R ++ ++ M+ Q+ +L +E+ L+ E + + L+ R +
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 263 ASESSRLKLEGSLRGELESRWE---KLRGLMEERLRALQGQHEESHLLEQC--QGLDAAV 317
+E R +L+ L E E+ E K R L + L+G ++ L +G + A+
Sbjct: 1593 QNEEKRRQLQRQLH-EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 318 AQLTKFVQQNQASLNRVLLAEEKAWD---AKGRLEESRAGELAA---YVQENLEAAQLA- 370
QL K +Q R L + D A + E +A L A +QE+L AA+ A
Sbjct: 1652 KQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 371 --GELARQEMHGELV-------LLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQE 421
+L ++E+ EL L+++ R LEA +AQL +L+E G++ A+S R+
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 422 QMLGLRLSEAKTEWEGAER--KSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCL 479
Q +E TE A++ + + L R KE+ L E + + +S
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL---HEMEGAVKSKFKSTIAALE 1827
Query: 480 LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQ 539
+ + ++ E + ++ +L+Q+ L + L ED RK+AE + A N
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQK-DKKLKEILLQVEDE--RKMAEQYKEQAEKGNA 1884
Query: 540 IMKLENCVQANKTIQNLRFNTEARLRTQEMATLWES 575
+K ++ R N R +E+ ES
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Score = 62.0 bits (149), Expect = 2e-09
Identities = 141/585 (24%), Positives = 249/585 (42%), Gaps = 129/585 (22%)
Query: 101 LRELLQV-RARVQLQGSELRQLQQEARPAAQAPEKEAPEFSG-----------LQNQMQA 148
++ LLQV R ++Q E Q+ + Q E E E LQ Q+QA
Sbjct: 848 VKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 149 LDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL-- 206
+ E E RL + +QE E E EA RL + D QQ + R+ +
Sbjct: 906 ETELYAEAEEMRVRLAAK--KQELEEILHEMEA--RLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 207 ---QKNQEDSSR-RVDLEVARMQAQVTKLGEEVSL-----RFLKREAKLCGFLQKSFLAL 257
Q +E+++R ++ LE +A++ KL +E+ + L +E KL L++ L
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEERISDL 1018
Query: 258 -----EKRMKASESSRLK-LEGSLRGELESRW---EKLRGLMEERLRALQGQHEESH--- 305
E+ KA ++LK S+ ELE R EK R +E+ R L+G + H
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 306 -------------LLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESR 352
L ++ + L AA+A+L + Q +L ++ E D + L+ R
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 353 AGELAAYVQ-----ENLEAAQ------LAGELARQEMHG----ELVLLR----EKSRALE 393
A A Q E LEA + L +QE+ E+ +L+ E++R+ E
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 394 ASV-------AQLAGQLKELSGHLPALSSRLDLQEQMLGLR----------LSEAKTEWE 436
A V AQ +L E + LD +Q L L +AK E E
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 437 GAERKSLEDLARWRKEVTEHLRG---VREKVDGLPQQIESVSDKCLLHKSDSDLRISAEG 493
++K + + + ++ R + +KV L ++ESV + + AEG
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----------TGMLNEAEG 1308
Query: 494 KAREFKVGALRQELATLLSSVQ----LLKED-----NPGRKIAEMQGKLATFQNQI---M 541
KA + L +++A+L S +Q LL+E+ N K+ +++ + + Q+Q+ M
Sbjct: 1309 KAIK-----LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 542 KLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPR 586
+ + ++ + + N++ ++++ + Q+ A+ E++ EEG +
Sbjct: 1364 EAKQNLERHISTLNIQL-SDSKKKLQDFASTVEAL-----EEGKK 1402
Score = 57.8 bits (138), Expect = 3e-08
Identities = 107/515 (20%), Positives = 221/515 (42%), Gaps = 51/515 (9%)
Query: 62 EQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQ------LQG 115
+ + K +LE + +LQ ++ R + + E+ R L EL ++ ++
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 116 SELR-QLQQEARPAAQAPEKEAPEFSG-LQNQMQALDKRLVEVREALTRLRRRQV----- 168
ELR + +QE +A ++E +Q Q + + E+ E L + +R +
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 169 QQEAERRGAEQEAGLR-LAKLTDLLQQEEQGREVACGALQKNQEDSSR-RVDL--EVARM 224
+Q E+ A+ LR L + ++ +++ E LQ D R R +L +V ++
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 225 QAQVTKL------GEEVSLRFLKREAKLCGFLQ--KSFLALEKRMKASESSRLKL----E 272
Q +V + E +++ K A L LQ + L E R K + S++L+
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 273 GSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLN 332
SL+ +L+ E + L E + L Q +S ++ Q + V L + ++ Q +
Sbjct: 1353 NSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSK--KKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 333 RVLLAEEKAWDAKGRLEESR---AGELAAYVQENLEAAQLAGELARQEMHGELVLLREKS 389
+ E+ A +LE+++ EL V + QL L +++ + +L EK+
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 390 RALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAE---RKSLEDL 446
+ + + + + + ALS L+E + EAK E E + +EDL
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEAL------EAKEELERTNKMLKAEMEDL 1523
Query: 447 ARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAR-EFKVGALRQ 505
+ +V +++ + + L Q+E + K L + + +L+ + + K R E + AL+
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 506 ELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQI 540
+ L + +++ K ++Q +L ++ ++
Sbjct: 1582 QFERDLQA----RDEQNEEKRRQLQRQLHEYETEL 1612
Score = 32.7 bits (73), Expect = 1.1
Identities = 23/109 (21%), Positives = 55/109 (50%), Gaps = 8/109 (7%)
Query: 42 LEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERAT---R 98
LEE E+ +T S+ ++D +L++ +++++ E ++K++ E+ +
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKD-----KKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 99 SLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQ 147
L R+L + Q + R+LQ+E A ++ E E + L+++++
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 80.1 bits (196), Expect = 6e-15
Identities = 128/576 (22%), Positives = 235/576 (40%), Gaps = 59/576 (10%)
Query: 43 EELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLR 102
EE+ + ST ++ D+ K + + + V L E K+R ++ +L +
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKK-------LQDFASTVEALEEGKKRFQKEIENLTQ 1413
Query: 103 ELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTR 162
+ + A +LQQE + + S L+ + + D+ L E + ++
Sbjct: 1414 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1473
Query: 163 LRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQED---------- 212
+ + EAE R E +A L LA+ + + ++ E L+ ED
Sbjct: 1474 YADERDRAEAEAREKETKA-LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1532
Query: 213 -------SSRRVDLEVARMQAQVTKLGEEVSLRF---LKREAKLCGFLQKSFLALEKRMK 262
S R ++ ++ M+ Q+ +L +E+ L+ E + + L+ R +
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 263 ASESSRLKLEGSLRGELESRWE---KLRGLMEERLRALQGQHEESHLLEQC--QGLDAAV 317
+E R +L+ L E E+ E K R L + L+G ++ L +G + A+
Sbjct: 1593 QNEEKRRQLQRQLH-EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 318 AQLTKFVQQNQASLNRVLLAEEKAWD---AKGRLEESRAGELAA---YVQENLEAAQLA- 370
QL K +Q R L + D A + E +A L A +QE+L AA+ A
Sbjct: 1652 KQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 371 --GELARQEMHGELV-------LLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQE 421
+L ++E+ EL L+++ R LEA +AQL +L+E G++ A+S R+
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 422 QMLGLRLSEAKTEWEGAER--KSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCL 479
Q +E TE A++ + + L R KE+ L E + + +S
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL---HEMEGAVKSKFKSTIAALE 1827
Query: 480 LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQ 539
+ + ++ E + ++ +L+Q+ L + L ED RK+AE + A N
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQK-DKKLKEILLQVEDE--RKMAEQYKEQAEKGNA 1884
Query: 540 IMKLENCVQANKTIQNLRFNTEARLRTQEMATLWES 575
+K ++ R N R +E+ ES
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Score = 62.0 bits (149), Expect = 2e-09
Identities = 141/585 (24%), Positives = 249/585 (42%), Gaps = 129/585 (22%)
Query: 101 LRELLQV-RARVQLQGSELRQLQQEARPAAQAPEKEAPEFSG-----------LQNQMQA 148
++ LLQV R ++Q E Q+ + Q E E E LQ Q+QA
Sbjct: 848 VKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 905
Query: 149 LDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL-- 206
+ E E RL + +QE E E EA RL + D QQ + R+ +
Sbjct: 906 ETELYAEAEEMRVRLAAK--KQELEEILHEMEA--RLEEEEDRGQQLQAERKKMAQQMLD 961
Query: 207 ---QKNQEDSSR-RVDLEVARMQAQVTKLGEEVSL-----RFLKREAKLCGFLQKSFLAL 257
Q +E+++R ++ LE +A++ KL +E+ + L +E KL L++ L
Sbjct: 962 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEERISDL 1018
Query: 258 -----EKRMKASESSRLK-LEGSLRGELESRW---EKLRGLMEERLRALQGQHEESH--- 305
E+ KA ++LK S+ ELE R EK R +E+ R L+G + H
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 306 -------------LLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESR 352
L ++ + L AA+A+L + Q +L ++ E D + L+ R
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138
Query: 353 AGELAAYVQ-----ENLEAAQ------LAGELARQEMHG----ELVLLR----EKSRALE 393
A A Q E LEA + L +QE+ E+ +L+ E++R+ E
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1198
Query: 394 ASV-------AQLAGQLKELSGHLPALSSRLDLQEQMLGLR----------LSEAKTEWE 436
A V AQ +L E + LD +Q L L +AK E E
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 437 GAERKSLEDLARWRKEVTEHLRG---VREKVDGLPQQIESVSDKCLLHKSDSDLRISAEG 493
++K + + + ++ R + +KV L ++ESV + + AEG
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----------TGMLNEAEG 1308
Query: 494 KAREFKVGALRQELATLLSSVQ----LLKED-----NPGRKIAEMQGKLATFQNQI---M 541
KA + L +++A+L S +Q LL+E+ N K+ +++ + + Q+Q+ M
Sbjct: 1309 KAIK-----LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 542 KLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPR 586
+ + ++ + + N++ ++++ + Q+ A+ E++ EEG +
Sbjct: 1364 EAKQNLERHISTLNIQL-SDSKKKLQDFASTVEAL-----EEGKK 1402
Score = 57.8 bits (138), Expect = 3e-08
Identities = 107/515 (20%), Positives = 221/515 (42%), Gaps = 51/515 (9%)
Query: 62 EQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQ------LQG 115
+ + K +LE + +LQ ++ R + + E+ R L EL ++ ++
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 116 SELR-QLQQEARPAAQAPEKEAPEFSG-LQNQMQALDKRLVEVREALTRLRRRQV----- 168
ELR + +QE +A ++E +Q Q + + E+ E L + +R +
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 169 QQEAERRGAEQEAGLR-LAKLTDLLQQEEQGREVACGALQKNQEDSSR-RVDL--EVARM 224
+Q E+ A+ LR L + ++ +++ E LQ D R R +L +V ++
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 225 QAQVTKL------GEEVSLRFLKREAKLCGFLQ--KSFLALEKRMKASESSRLKL----E 272
Q +V + E +++ K A L LQ + L E R K + S++L+
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 273 GSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLN 332
SL+ +L+ E + L E + L Q +S ++ Q + V L + ++ Q +
Sbjct: 1353 NSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSK--KKLQDFASTVEALEEGKKRFQKEIE 1409
Query: 333 RVLLAEEKAWDAKGRLEESR---AGELAAYVQENLEAAQLAGELARQEMHGELVLLREKS 389
+ E+ A +LE+++ EL V + QL L +++ + +L EK+
Sbjct: 1410 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1469
Query: 390 RALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAE---RKSLEDL 446
+ + + + + + ALS L+E + EAK E E + +EDL
Sbjct: 1470 ISSKYADERDRAEAEAREKETKALSLARALEEAL------EAKEELERTNKMLKAEMEDL 1523
Query: 447 ARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAR-EFKVGALRQ 505
+ +V +++ + + L Q+E + K L + + +L+ + + K R E + AL+
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 506 ELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQI 540
+ L + +++ K ++Q +L ++ ++
Sbjct: 1582 QFERDLQA----RDEQNEEKRRQLQRQLHEYETEL 1612
Score = 32.7 bits (73), Expect = 1.1
Identities = 23/109 (21%), Positives = 55/109 (50%), Gaps = 8/109 (7%)
Query: 42 LEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERAT---R 98
LEE E+ +T S+ ++D +L++ +++++ E ++K++ E+ +
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKD-----KKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 99 SLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQ 147
L R+L + Q + R+LQ+E A ++ E E + L+++++
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 80.1 bits (196), Expect = 6e-15
Identities = 128/576 (22%), Positives = 235/576 (40%), Gaps = 59/576 (10%)
Query: 43 EELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLR 102
EE+ + ST ++ D+ K + + + V L E K+R ++ +L +
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKK-------LQDFASTVEALEEGKKRFQKEIENLTQ 1406
Query: 103 ELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTR 162
+ + A +LQQE + + S L+ + + D+ L E + ++
Sbjct: 1407 QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSK 1466
Query: 163 LRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQED---------- 212
+ + EAE R E +A L LA+ + + ++ E L+ ED
Sbjct: 1467 YADERDRAEAEAREKETKA-LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525
Query: 213 -------SSRRVDLEVARMQAQVTKLGEEVSLRF---LKREAKLCGFLQKSFLALEKRMK 262
S R ++ ++ M+ Q+ +L +E+ L+ E + + L+ R +
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 263 ASESSRLKLEGSLRGELESRWE---KLRGLMEERLRALQGQHEESHLLEQC--QGLDAAV 317
+E R +L+ L E E+ E K R L + L+G ++ L +G + A+
Sbjct: 1586 QNEEKRRQLQRQLH-EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 318 AQLTKFVQQNQASLNRVLLAEEKAWD---AKGRLEESRAGELAA---YVQENLEAAQLA- 370
QL K +Q R L + D A + E +A L A +QE+L AA+ A
Sbjct: 1645 KQLRK-LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR 1703
Query: 371 --GELARQEMHGELV-------LLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQE 421
+L ++E+ EL L+++ R LEA +AQL +L+E G++ A+S R+
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 422 QMLGLRLSEAKTEWEGAER--KSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCL 479
Q +E TE A++ + + L R KE+ L E + + +S
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL---HEMEGAVKSKFKSTIAALE 1820
Query: 480 LHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQ 539
+ + ++ E + ++ +L+Q+ L + L ED RK+AE + A N
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQK-DKKLKEILLQVEDE--RKMAEQYKEQAEKGNA 1877
Query: 540 IMKLENCVQANKTIQNLRFNTEARLRTQEMATLWES 575
+K ++ R N R +E+ ES
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Score = 62.0 bits (149), Expect = 2e-09
Identities = 141/585 (24%), Positives = 249/585 (42%), Gaps = 129/585 (22%)
Query: 101 LRELLQV-RARVQLQGSELRQLQQEARPAAQAPEKEAPEFSG-----------LQNQMQA 148
++ LLQV R ++Q E Q+ + Q E E E LQ Q+QA
Sbjct: 841 VKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQA 898
Query: 149 LDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL-- 206
+ E E RL + +QE E E EA RL + D QQ + R+ +
Sbjct: 899 ETELYAEAEEMRVRLAAK--KQELEEILHEMEA--RLEEEEDRGQQLQAERKKMAQQMLD 954
Query: 207 ---QKNQEDSSR-RVDLEVARMQAQVTKLGEEVSL-----RFLKREAKLCGFLQKSFLAL 257
Q +E+++R ++ LE +A++ KL +E+ + L +E KL L++ L
Sbjct: 955 LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL---LEERISDL 1011
Query: 258 -----EKRMKASESSRLK-LEGSLRGELESRW---EKLRGLMEERLRALQGQHEESH--- 305
E+ KA ++LK S+ ELE R EK R +E+ R L+G + H
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 306 -------------LLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESR 352
L ++ + L AA+A+L + Q +L ++ E D + L+ R
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131
Query: 353 AGELAAYVQ-----ENLEAAQ------LAGELARQEMHG----ELVLLR----EKSRALE 393
A A Q E LEA + L +QE+ E+ +L+ E++R+ E
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE 1191
Query: 394 ASV-------AQLAGQLKELSGHLPALSSRLDLQEQMLGLR----------LSEAKTEWE 436
A V AQ +L E + LD +Q L L +AK E E
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 437 GAERKSLEDLARWRKEVTEHLRG---VREKVDGLPQQIESVSDKCLLHKSDSDLRISAEG 493
++K + + + ++ R + +KV L ++ESV + + AEG
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV----------TGMLNEAEG 1301
Query: 494 KAREFKVGALRQELATLLSSVQ----LLKED-----NPGRKIAEMQGKLATFQNQI---M 541
KA + L +++A+L S +Q LL+E+ N K+ +++ + + Q+Q+ M
Sbjct: 1302 KAIK-----LAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 542 KLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPR 586
+ + ++ + + N++ ++++ + Q+ A+ E++ EEG +
Sbjct: 1357 EAKQNLERHISTLNIQL-SDSKKKLQDFASTVEAL-----EEGKK 1395
Score = 57.8 bits (138), Expect = 3e-08
Identities = 107/515 (20%), Positives = 221/515 (42%), Gaps = 51/515 (9%)
Query: 62 EQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQ------LQG 115
+ + K +LE + +LQ ++ R + + E+ R L EL ++ ++
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 116 SELR-QLQQEARPAAQAPEKEAPEFSG-LQNQMQALDKRLVEVREALTRLRRRQV----- 168
ELR + +QE +A ++E +Q Q + + E+ E L + +R +
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 169 QQEAERRGAEQEAGLR-LAKLTDLLQQEEQGREVACGALQKNQEDSSR-RVDL--EVARM 224
+Q E+ A+ LR L + ++ +++ E LQ D R R +L +V ++
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 225 QAQVTKL------GEEVSLRFLKREAKLCGFLQ--KSFLALEKRMKASESSRLKL----E 272
Q +V + E +++ K A L LQ + L E R K + S++L+
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 273 GSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLN 332
SL+ +L+ E + L E + L Q +S ++ Q + V L + ++ Q +
Sbjct: 1346 NSLQDQLDEEMEAKQNL-ERHISTLNIQLSDSK--KKLQDFASTVEALEEGKKRFQKEIE 1402
Query: 333 RVLLAEEKAWDAKGRLEESR---AGELAAYVQENLEAAQLAGELARQEMHGELVLLREKS 389
+ E+ A +LE+++ EL V + QL L +++ + +L EK+
Sbjct: 1403 NLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKN 1462
Query: 390 RALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAE---RKSLEDL 446
+ + + + + + ALS L+E + EAK E E + +EDL
Sbjct: 1463 ISSKYADERDRAEAEAREKETKALSLARALEEAL------EAKEELERTNKMLKAEMEDL 1516
Query: 447 ARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAR-EFKVGALRQ 505
+ +V +++ + + L Q+E + K L + + +L+ + + K R E + AL+
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEM--KTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 506 ELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQI 540
+ L + +++ K ++Q +L ++ ++
Sbjct: 1575 QFERDLQA----RDEQNEEKRRQLQRQLHEYETEL 1605
Score = 32.7 bits (73), Expect = 1.1
Identities = 23/109 (21%), Positives = 55/109 (50%), Gaps = 8/109 (7%)
Query: 42 LEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERAT---R 98
LEE E+ +T S+ ++D +L++ +++++ E ++K++ E+ +
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKD-----KKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 99 SLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQ 147
L R+L + Q + R+LQ+E A ++ E E + L+++++
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 76.6 bits (187), Expect = 7e-14
Identities = 121/533 (22%), Positives = 223/533 (41%), Gaps = 45/533 (8%)
Query: 71 QLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQ 130
+LE V EL+A V E ++ + + L + + ++ A ++ + ++LQ E
Sbjct: 944 ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEA 1003
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQ---EAGLRLAK 187
+K + L++Q L K + + L + ++E + + + + +A
Sbjct: 1004 KMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD 1063
Query: 188 LTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLC 247
+ D L++EE+GR+ E RR+D E + +Q Q+ E R + A+L
Sbjct: 1064 MEDRLRKEEKGRQ--------ELEKLKRRLDGESSELQEQMV----EQQQRAEELRAQL- 1110
Query: 248 GFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLL 307
G ++ A R + +R +L SLR + E L ER+ + + + L
Sbjct: 1111 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1170
Query: 308 EQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAA 367
E+ L+A +L + A E++ + K LEE AA +
Sbjct: 1171 EE---LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227
Query: 368 QLAGELARQ-EMHGELVLLREKSR-ALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLG 425
Q GELA Q E EK+R ALEA V++L +L L + + + L
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ----TARQEGEQRRRRLE 1283
Query: 426 LRLSEAK---TEWEGAERKSLEDLARWRKE---VTEHLRGVREKVDGLPQQIESV----- 474
L+L E + + E A ++ E L R + E V+ L K L +++ S
Sbjct: 1284 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH 1343
Query: 475 -SDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKL 533
+ + L ++ + L + + +A E + LR++L + + GR++ Q +L
Sbjct: 1344 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQL-----EEEAAARERAGRELQTAQAQL 1398
Query: 534 ATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPR 586
+ ++ + + ++A + + R EA TQ +A E+V RL E G R
Sbjct: 1399 SEWRRRQEEEAGALEAGEEARR-RAAREAEALTQRLAEKTETVDRL--ERGRR 1448
Score = 70.9 bits (172), Expect = 4e-12
Identities = 116/536 (21%), Positives = 214/536 (39%), Gaps = 83/536 (15%)
Query: 86 LREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQ 145
L + K+R + + L ++++ + R + ++L + ++E + A E E + L
Sbjct: 1078 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKS 1137
Query: 146 MQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLL------QQEEQGR 199
++ L E +E L R + + E +RR +E +L D L Q+ R
Sbjct: 1138 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR 1197
Query: 200 EVACGALQKNQEDSSRRVDLEVARM-QAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALE 258
E L+K E+ +R + V + Q LGE R K G +K+ LALE
Sbjct: 1198 EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK--GAWEKTRLALE 1255
Query: 259 KRMKASESSRLKLEGSLRGELESRWEKLR-GLMEERLRALQGQHEESHLLEQCQGLDAAV 317
+ + L+ + R E E R +L L E + RA G+ + E+ Q A +
Sbjct: 1256 AEVSELRAELSSLQ-TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAEL 1314
Query: 318 AQLTKFVQQNQASLNRVLLAEE------KAWDAKGRLEESRAGELAAYVQENLEAAQLAG 371
++ + N+A + L++E + DA+ L+E +LA + A+ AG
Sbjct: 1315 ENVSGAL--NEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAG 1372
Query: 372 ELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEA 431
R+++ E R L+ + AQL+ + AL + + + + R +EA
Sbjct: 1373 --LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR--AAREAEA 1428
Query: 432 KTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDK-------------C 478
T+ + ++++ L R R+ + + L ++ Q + ++ K
Sbjct: 1429 LTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAA 1488
Query: 479 LLHKSDSDLRISAEGKAREFKV---------------------GALRQELATLLSSVQLL 517
+L + R AEG+ RE + ALR EL LLSS
Sbjct: 1489 VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS---- 1544
Query: 518 KEDNPGR---------------------KIAEMQGKLATFQNQIMKLENCVQANKT 552
+D+ G+ ++ E++ +L ++ ++LE VQA KT
Sbjct: 1545 -KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT 1599
Score = 50.1 bits (118), Expect = 7e-06
Identities = 89/360 (24%), Positives = 147/360 (40%), Gaps = 67/360 (18%)
Query: 81 AEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFS 140
AEV E KQR L V AR +L+G EL +L+ + A Q E+ +
Sbjct: 1626 AEVERDEERKQRT-----------LAVAARKKLEG-ELEELKAQMASAGQGKEEAVKQLR 1673
Query: 141 GLQNQMQAL---------------------DKRLVEVREALTRLRRRQVQQEAERRGAEQ 179
+Q QM+ L +KRL + + RL+ + RR A+Q
Sbjct: 1674 KMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1733
Query: 180 EAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRF 239
+ ++E EVA G L K +R LE R+ +L EE S
Sbjct: 1734 D-------------RDEMADEVANGNLSKAAILEEKR-QLE-GRLGQLEEELEEEQSNSE 1778
Query: 240 LKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQG 299
L + LQ L E + S S++ + S R +LE + ++LRG + E +
Sbjct: 1779 LLNDRYRKLLLQVESLTTELSAERSFSAKAE---SGRQQLERQIQELRGRLGEEDAGARA 1835
Query: 300 QHE------ESHLLEQCQGLDAAVAQLT---KFVQQNQASLNRVLLAEEK----AWDAKG 346
+H+ ES L + + L+ + K V++ + L V+L E+ A +
Sbjct: 1836 RHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRD 1895
Query: 347 RLEES--RAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLK 404
+LE+ R +L ++E E A A + R+ + EL + E + ++ V L +L+
Sbjct: 1896 QLEKGNLRVKQLKRQLEEAEEEASRA-QAGRRRLQRELEDVTESAESMNREVTTLRNRLR 1954
Score = 48.9 bits (115), Expect = 1e-05
Identities = 111/465 (23%), Positives = 199/465 (42%), Gaps = 44/465 (9%)
Query: 16 SQLRAVTLEDLGLLLAGGLASPEPL-SLEELSERYESSHPTSTASVPEQDTAKHWNQLEQ 74
S+ R E+ G L AG A E L++R + T T E+ + +L+
Sbjct: 1399 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL--AEKTETVDRLERGRRRLQQELDD 1456
Query: 75 WVVEL--QAEVACLREHKQRCERATRSLLRELLQV-RARVQLQGSELRQLQQEARPAA-- 129
++L Q ++ E KQR + + L E V RA + + +E ++EAR +
Sbjct: 1457 ATMDLEQQRQLVSTLEKKQR--KFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1514
Query: 130 QAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLT 189
+A E+E L+ Q +AL L + + + + + E R AEQ A A++T
Sbjct: 1515 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1574
Query: 190 DLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGF 249
+L + ED+ R+++ V ++ Q + + +R +L
Sbjct: 1575 ELEDELTAA------------EDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ 1622
Query: 250 LQKSFLALEKRMK---ASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHL 306
L+ + + ++ K + ++R KLEG L EL+++ EE ++ L+ ++ +
Sbjct: 1623 LRDAEVERDEERKQRTLAVAARKKLEGELE-ELKAQMASAGQGKEEAVKQLRKM--QAQM 1679
Query: 307 LEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEA 366
E + ++ + QN+ S R+ E + RL+E ELAA + +A
Sbjct: 1680 KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----RLQE----ELAASDRARRQA 1731
Query: 367 AQLAGELARQEMHGEL--VLLREKSRALEASVAQLAGQLKELSGHLPALSSR---LDLQE 421
Q E+A + +G L + E+ R LE + QL +L+E + L+ R L LQ
Sbjct: 1732 QQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQV 1791
Query: 422 QMLGLRLSEAKTEWEGAE--RKSLE-DLARWRKEVTEHLRGVREK 463
+ L LS ++ AE R+ LE + R + E G R +
Sbjct: 1792 ESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1836
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 76.6 bits (187), Expect = 7e-14
Identities = 121/533 (22%), Positives = 223/533 (41%), Gaps = 45/533 (8%)
Query: 71 QLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQ 130
+LE V EL+A V E ++ + + L + + ++ A ++ + ++LQ E
Sbjct: 936 ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEA 995
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQ---EAGLRLAK 187
+K + L++Q L K + + L + ++E + + + + +A
Sbjct: 996 KMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD 1055
Query: 188 LTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLC 247
+ D L++EE+GR+ E RR+D E + +Q Q+ E R + A+L
Sbjct: 1056 MEDRLRKEEKGRQ--------ELEKLKRRLDGESSELQEQMV----EQQQRAEELRAQL- 1102
Query: 248 GFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLL 307
G ++ A R + +R +L SLR + E L ER+ + + + L
Sbjct: 1103 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1162
Query: 308 EQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAA 367
E+ L+A +L + A E++ + K LEE AA +
Sbjct: 1163 EE---LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219
Query: 368 QLAGELARQ-EMHGELVLLREKSR-ALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLG 425
Q GELA Q E EK+R ALEA V++L +L L + + + L
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ----TARQEGEQRRRRLE 1275
Query: 426 LRLSEAK---TEWEGAERKSLEDLARWRKE---VTEHLRGVREKVDGLPQQIESV----- 474
L+L E + + E A ++ E L R + E V+ L K L +++ S
Sbjct: 1276 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH 1335
Query: 475 -SDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKL 533
+ + L ++ + L + + +A E + LR++L + + GR++ Q +L
Sbjct: 1336 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQL-----EEEAAARERAGRELQTAQAQL 1390
Query: 534 ATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPR 586
+ ++ + + ++A + + R EA TQ +A E+V RL E G R
Sbjct: 1391 SEWRRRQEEEAGALEAGEEARR-RAAREAEALTQRLAEKTETVDRL--ERGRR 1440
Score = 70.9 bits (172), Expect = 4e-12
Identities = 116/536 (21%), Positives = 214/536 (39%), Gaps = 83/536 (15%)
Query: 86 LREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQ 145
L + K+R + + L ++++ + R + ++L + ++E + A E E + L
Sbjct: 1070 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKS 1129
Query: 146 MQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLL------QQEEQGR 199
++ L E +E L R + + E +RR +E +L D L Q+ R
Sbjct: 1130 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR 1189
Query: 200 EVACGALQKNQEDSSRRVDLEVARM-QAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALE 258
E L+K E+ +R + V + Q LGE R K G +K+ LALE
Sbjct: 1190 EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK--GAWEKTRLALE 1247
Query: 259 KRMKASESSRLKLEGSLRGELESRWEKLR-GLMEERLRALQGQHEESHLLEQCQGLDAAV 317
+ + L+ + R E E R +L L E + RA G+ + E+ Q A +
Sbjct: 1248 AEVSELRAELSSLQ-TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAEL 1306
Query: 318 AQLTKFVQQNQASLNRVLLAEE------KAWDAKGRLEESRAGELAAYVQENLEAAQLAG 371
++ + N+A + L++E + DA+ L+E +LA + A+ AG
Sbjct: 1307 ENVSGAL--NEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAG 1364
Query: 372 ELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEA 431
R+++ E R L+ + AQL+ + AL + + + + R +EA
Sbjct: 1365 --LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR--AAREAEA 1420
Query: 432 KTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDK-------------C 478
T+ + ++++ L R R+ + + L ++ Q + ++ K
Sbjct: 1421 LTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAA 1480
Query: 479 LLHKSDSDLRISAEGKAREFKV---------------------GALRQELATLLSSVQLL 517
+L + R AEG+ RE + ALR EL LLSS
Sbjct: 1481 VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS---- 1536
Query: 518 KEDNPGR---------------------KIAEMQGKLATFQNQIMKLENCVQANKT 552
+D+ G+ ++ E++ +L ++ ++LE VQA KT
Sbjct: 1537 -KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT 1591
Score = 50.1 bits (118), Expect = 7e-06
Identities = 89/360 (24%), Positives = 147/360 (40%), Gaps = 67/360 (18%)
Query: 81 AEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFS 140
AEV E KQR L V AR +L+G EL +L+ + A Q E+ +
Sbjct: 1618 AEVERDEERKQRT-----------LAVAARKKLEG-ELEELKAQMASAGQGKEEAVKQLR 1665
Query: 141 GLQNQMQAL---------------------DKRLVEVREALTRLRRRQVQQEAERRGAEQ 179
+Q QM+ L +KRL + + RL+ + RR A+Q
Sbjct: 1666 KMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1725
Query: 180 EAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRF 239
+ ++E EVA G L K +R LE R+ +L EE S
Sbjct: 1726 D-------------RDEMADEVANGNLSKAAILEEKR-QLE-GRLGQLEEELEEEQSNSE 1770
Query: 240 LKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQG 299
L + LQ L E + S S++ + S R +LE + ++LRG + E +
Sbjct: 1771 LLNDRYRKLLLQVESLTTELSAERSFSAKAE---SGRQQLERQIQELRGRLGEEDAGARA 1827
Query: 300 QHE------ESHLLEQCQGLDAAVAQLT---KFVQQNQASLNRVLLAEEK----AWDAKG 346
+H+ ES L + + L+ + K V++ + L V+L E+ A +
Sbjct: 1828 RHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRD 1887
Query: 347 RLEES--RAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLK 404
+LE+ R +L ++E E A A + R+ + EL + E + ++ V L +L+
Sbjct: 1888 QLEKGNLRVKQLKRQLEEAEEEASRA-QAGRRRLQRELEDVTESAESMNREVTTLRNRLR 1946
Score = 48.9 bits (115), Expect = 1e-05
Identities = 111/465 (23%), Positives = 199/465 (42%), Gaps = 44/465 (9%)
Query: 16 SQLRAVTLEDLGLLLAGGLASPEPL-SLEELSERYESSHPTSTASVPEQDTAKHWNQLEQ 74
S+ R E+ G L AG A E L++R + T T E+ + +L+
Sbjct: 1391 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL--AEKTETVDRLERGRRRLQQELDD 1448
Query: 75 WVVEL--QAEVACLREHKQRCERATRSLLRELLQV-RARVQLQGSELRQLQQEARPAA-- 129
++L Q ++ E KQR + + L E V RA + + +E ++EAR +
Sbjct: 1449 ATMDLEQQRQLVSTLEKKQR--KFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1506
Query: 130 QAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLT 189
+A E+E L+ Q +AL L + + + + + E R AEQ A A++T
Sbjct: 1507 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1566
Query: 190 DLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGF 249
+L + ED+ R+++ V ++ Q + + +R +L
Sbjct: 1567 ELEDELTAA------------EDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ 1614
Query: 250 LQKSFLALEKRMK---ASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHL 306
L+ + + ++ K + ++R KLEG L EL+++ EE ++ L+ ++ +
Sbjct: 1615 LRDAEVERDEERKQRTLAVAARKKLEGELE-ELKAQMASAGQGKEEAVKQLRKM--QAQM 1671
Query: 307 LEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEA 366
E + ++ + QN+ S R+ E + RL+E ELAA + +A
Sbjct: 1672 KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----RLQE----ELAASDRARRQA 1723
Query: 367 AQLAGELARQEMHGEL--VLLREKSRALEASVAQLAGQLKELSGHLPALSSR---LDLQE 421
Q E+A + +G L + E+ R LE + QL +L+E + L+ R L LQ
Sbjct: 1724 QQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQV 1783
Query: 422 QMLGLRLSEAKTEWEGAE--RKSLE-DLARWRKEVTEHLRGVREK 463
+ L LS ++ AE R+ LE + R + E G R +
Sbjct: 1784 ESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1828
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 76.6 bits (187), Expect = 7e-14
Identities = 121/533 (22%), Positives = 223/533 (41%), Gaps = 45/533 (8%)
Query: 71 QLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQ 130
+LE V EL+A V E ++ + + L + + ++ A ++ + ++LQ E
Sbjct: 977 ELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEA 1036
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQ---EAGLRLAK 187
+K + L++Q L K + + L + ++E + + + + +A
Sbjct: 1037 KMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIAD 1096
Query: 188 LTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLC 247
+ D L++EE+GR+ E RR+D E + +Q Q+ E R + A+L
Sbjct: 1097 MEDRLRKEEKGRQ--------ELEKLKRRLDGESSELQEQMV----EQQQRAEELRAQL- 1143
Query: 248 GFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLL 307
G ++ A R + +R +L SLR + E L ER+ + + + L
Sbjct: 1144 GRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLG 1203
Query: 308 EQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAA 367
E+ L+A +L + A E++ + K LEE AA +
Sbjct: 1204 EE---LEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260
Query: 368 QLAGELARQ-EMHGELVLLREKSR-ALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLG 425
Q GELA Q E EK+R ALEA V++L +L L + + + L
Sbjct: 1261 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQ----TARQEGEQRRRRLE 1316
Query: 426 LRLSEAK---TEWEGAERKSLEDLARWRKE---VTEHLRGVREKVDGLPQQIESV----- 474
L+L E + + E A ++ E L R + E V+ L K L +++ S
Sbjct: 1317 LQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH 1376
Query: 475 -SDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKL 533
+ + L ++ + L + + +A E + LR++L + + GR++ Q +L
Sbjct: 1377 DAQELLQEETRAKLALGSRVRAMEAEAAGLREQL-----EEEAAARERAGRELQTAQAQL 1431
Query: 534 ATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPR 586
+ ++ + + ++A + + R EA TQ +A E+V RL E G R
Sbjct: 1432 SEWRRRQEEEAGALEAGEEARR-RAAREAEALTQRLAEKTETVDRL--ERGRR 1481
Score = 70.9 bits (172), Expect = 4e-12
Identities = 116/536 (21%), Positives = 214/536 (39%), Gaps = 83/536 (15%)
Query: 86 LREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQ 145
L + K+R + + L ++++ + R + ++L + ++E + A E E + L
Sbjct: 1111 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKS 1170
Query: 146 MQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLL------QQEEQGR 199
++ L E +E L R + + E +RR +E +L D L Q+ R
Sbjct: 1171 LREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKR 1230
Query: 200 EVACGALQKNQEDSSRRVDLEVARM-QAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALE 258
E L+K E+ +R + V + Q LGE R K G +K+ LALE
Sbjct: 1231 EQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK--GAWEKTRLALE 1288
Query: 259 KRMKASESSRLKLEGSLRGELESRWEKLR-GLMEERLRALQGQHEESHLLEQCQGLDAAV 317
+ + L+ + R E E R +L L E + RA G+ + E+ Q A +
Sbjct: 1289 AEVSELRAELSSLQ-TARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAEL 1347
Query: 318 AQLTKFVQQNQASLNRVLLAEE------KAWDAKGRLEESRAGELAAYVQENLEAAQLAG 371
++ + N+A + L++E + DA+ L+E +LA + A+ AG
Sbjct: 1348 ENVSGAL--NEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAG 1405
Query: 372 ELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEA 431
R+++ E R L+ + AQL+ + AL + + + + R +EA
Sbjct: 1406 --LREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRR--AAREAEA 1461
Query: 432 KTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDK-------------C 478
T+ + ++++ L R R+ + + L ++ Q + ++ K
Sbjct: 1462 LTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAA 1521
Query: 479 LLHKSDSDLRISAEGKAREFKV---------------------GALRQELATLLSSVQLL 517
+L + R AEG+ RE + ALR EL LLSS
Sbjct: 1522 VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS---- 1577
Query: 518 KEDNPGR---------------------KIAEMQGKLATFQNQIMKLENCVQANKT 552
+D+ G+ ++ E++ +L ++ ++LE VQA KT
Sbjct: 1578 -KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKT 1632
Score = 50.1 bits (118), Expect = 7e-06
Identities = 89/360 (24%), Positives = 147/360 (40%), Gaps = 67/360 (18%)
Query: 81 AEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFS 140
AEV E KQR L V AR +L+G EL +L+ + A Q E+ +
Sbjct: 1659 AEVERDEERKQRT-----------LAVAARKKLEG-ELEELKAQMASAGQGKEEAVKQLR 1706
Query: 141 GLQNQMQAL---------------------DKRLVEVREALTRLRRRQVQQEAERRGAEQ 179
+Q QM+ L +KRL + + RL+ + RR A+Q
Sbjct: 1707 KMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQ 1766
Query: 180 EAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRF 239
+ ++E EVA G L K +R LE R+ +L EE S
Sbjct: 1767 D-------------RDEMADEVANGNLSKAAILEEKR-QLE-GRLGQLEEELEEEQSNSE 1811
Query: 240 LKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQG 299
L + LQ L E + S S++ + S R +LE + ++LRG + E +
Sbjct: 1812 LLNDRYRKLLLQVESLTTELSAERSFSAKAE---SGRQQLERQIQELRGRLGEEDAGARA 1868
Query: 300 QHE------ESHLLEQCQGLDAAVAQLT---KFVQQNQASLNRVLLAEEK----AWDAKG 346
+H+ ES L + + L+ + K V++ + L V+L E+ A +
Sbjct: 1869 RHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRD 1928
Query: 347 RLEES--RAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLK 404
+LE+ R +L ++E E A A + R+ + EL + E + ++ V L +L+
Sbjct: 1929 QLEKGNLRVKQLKRQLEEAEEEASRA-QAGRRRLQRELEDVTESAESMNREVTTLRNRLR 1987
Score = 48.9 bits (115), Expect = 1e-05
Identities = 111/465 (23%), Positives = 199/465 (42%), Gaps = 44/465 (9%)
Query: 16 SQLRAVTLEDLGLLLAGGLASPEPL-SLEELSERYESSHPTSTASVPEQDTAKHWNQLEQ 74
S+ R E+ G L AG A E L++R + T T E+ + +L+
Sbjct: 1432 SEWRRRQEEEAGALEAGEEARRRAAREAEALTQRL--AEKTETVDRLERGRRRLQQELDD 1489
Query: 75 WVVEL--QAEVACLREHKQRCERATRSLLRELLQV-RARVQLQGSELRQLQQEARPAA-- 129
++L Q ++ E KQR + + L E V RA + + +E ++EAR +
Sbjct: 1490 ATMDLEQQRQLVSTLEKKQR--KFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLT 1547
Query: 130 QAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLT 189
+A E+E L+ Q +AL L + + + + + E R AEQ A A++T
Sbjct: 1548 RALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVT 1607
Query: 190 DLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGF 249
+L + ED+ R+++ V ++ Q + + +R +L
Sbjct: 1608 ELEDELTAA------------EDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQ 1655
Query: 250 LQKSFLALEKRMK---ASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHL 306
L+ + + ++ K + ++R KLEG L EL+++ EE ++ L+ ++ +
Sbjct: 1656 LRDAEVERDEERKQRTLAVAARKKLEGELE-ELKAQMASAGQGKEEAVKQLRKM--QAQM 1712
Query: 307 LEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEA 366
E + ++ + QN+ S R+ E + RL+E ELAA + +A
Sbjct: 1713 KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----RLQE----ELAASDRARRQA 1764
Query: 367 AQLAGELARQEMHGEL--VLLREKSRALEASVAQLAGQLKELSGHLPALSSR---LDLQE 421
Q E+A + +G L + E+ R LE + QL +L+E + L+ R L LQ
Sbjct: 1765 QQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQV 1824
Query: 422 QMLGLRLSEAKTEWEGAE--RKSLE-DLARWRKEVTEHLRGVREK 463
+ L LS ++ AE R+ LE + R + E G R +
Sbjct: 1825 ESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1869
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 76.6 bits (187), Expect = 7e-14
Identities = 124/551 (22%), Positives = 234/551 (42%), Gaps = 56/551 (10%)
Query: 64 DTAKHWNQLEQWVVELQAEVACLRE-------HKQRCERATRSLLRELLQVRARVQ---- 112
D H N + V ELQA++A L+E + + E+ R L EL ++ ++
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160
Query: 113 --LQGSELR-QLQQEARPAAQAPEKEAPEFSG-LQNQMQALDKRLVEVREALTRLRRRQV 168
ELR + +QE +A E+E +Q+ Q L E+ E L + +R +
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA 1220
Query: 169 QQEAERRGAE---QEAGLRLAKLTDLLQQEEQGREVACGALQ----KNQEDSSRRVDL-- 219
E ++G E +E + L + + E R+ +Q K E RV+L
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAE 1280
Query: 220 EVARMQAQVTKL------GEEVSLRFLKREAKLCGFLQ--KSFLALEKRMKASESSR--- 268
+ +++Q ++ + E+ ++F K A L LQ + L E R K + SSR
Sbjct: 1281 KASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQ 1340
Query: 269 LKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHL-----LEQCQGLDAAVAQLTKF 323
L+ E + E + E+ R +E+++ ALQ Q ++ L + L+ A +L K
Sbjct: 1341 LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKD 1400
Query: 324 VQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELV 383
+ L LA +K K RL++ EL + Q+A L +++ + +
Sbjct: 1401 AEALSQRLEEKALAYDKLEKTKNRLQQ----ELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 384 LLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAE---R 440
L EKS + + + + + ALS L+E + EAK E+E R
Sbjct: 1457 LAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL------EAKEEFERQNKQLR 1510
Query: 441 KSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAR-EFK 499
+EDL + +V +++ + + L QQ+E + + L + + +L+ + + K R E
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEM--RTQLEELEDELQATEDAKLRLEVN 1568
Query: 500 VGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFN 559
+ A++ + L + E+ I +++ A +++ + V + K ++ +
Sbjct: 1569 MQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKD 1628
Query: 560 TEARLRTQEMA 570
EA++ A
Sbjct: 1629 LEAQIEAANKA 1639
Score = 72.8 bits (177), Expect = 1e-12
Identities = 113/504 (22%), Positives = 212/504 (42%), Gaps = 56/504 (11%)
Query: 102 RELLQVRARVQLQ-GSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREAL 160
+ELLQ R +L S +RQL++E + E+E L+ Q+ AL +L +
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT---- 1376
Query: 161 TRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQK-----NQEDSSR 215
+++V + + +EA +L K + L Q + + +A L+K QE
Sbjct: 1377 ----KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDL 1432
Query: 216 RVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSL 275
VDL+ R A + ++ + L E + + E + E+ L L +L
Sbjct: 1433 TVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARAL 1492
Query: 276 RGELESRWE------KLRGLMEERLRALQGQHEESHLLEQC-----QGLDAAVAQLTKFV 324
LE++ E +LR ME+ + + + H LE+ Q ++ QL +
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE 1552
Query: 325 QQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVL 384
+ QA+ + L E K + E +L ++N E +L + R E+ EL
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFER----DLQTRDEQNEEKKRLLIKQVR-ELEAELED 1607
Query: 385 LREKSRALEASVAQLAGQLKELSGHLPALSSRLD---LQEQMLGLRLSEAKTEWEGAERK 441
R++ AS ++ LK+L + A + D Q + L ++ + + E E A R
Sbjct: 1608 ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEA-RA 1666
Query: 442 SLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSD------SDLRISAEGKA 495
S +++ KE + L+ + ++ L +++ S S++ H ++ SA GK+
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELAS-SERARRHAEQERDELADEITNSASGKS 1725
Query: 496 R--------EFKVGALRQELATLLSSVQLLKE--DNPGRKIAEMQGKLATFQNQIMKLEN 545
E ++ L +EL S+++LL + ++ + +LA ++ K +N
Sbjct: 1726 ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDN 1785
Query: 546 CVQANKTIQNLRFNTEARLRTQEM 569
Q Q R N E + + QE+
Sbjct: 1786 ARQ-----QLERQNKELKAKLQEL 1804
Score = 60.8 bits (146), Expect = 4e-09
Identities = 101/477 (21%), Positives = 197/477 (41%), Gaps = 94/477 (19%)
Query: 87 REHKQRCE---------RATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAP 137
R+H+Q E +A L E ++RAR+ + EL ++ + + E+
Sbjct: 880 RKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQ 939
Query: 138 EFSGLQNQMQA----LDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGL---------- 183
+ +MQA L+++L E A +L+ +V EA+ + E+E L
Sbjct: 940 ILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIK 999
Query: 184 -------RLAKLTDLLQQEEQ----------GREVACGALQ----------KNQEDSSRR 216
R+A+ + L +EE+ +EV L+ + E + R+
Sbjct: 1000 EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRK 1059
Query: 217 VDLEVARMQAQVTKLG---EEVSLRFLKREAKLCGF--------------------LQKS 253
+D E +Q Q+ +L +E+ L+ K+E +L G LQ
Sbjct: 1060 LDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 254 FLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHE-----ESHLLE 308
L++ ++ ++SR K E R +L E L+ +E+ L Q E E + E
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKR-DLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE 1178
Query: 309 QCQGLDAAV----AQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAG------ELAA 358
+ L+ AQ+ Q++ +L + E+A K LE+++ G ELA
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC 1238
Query: 359 YVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLD 418
V+ L+ + E R+++ ++ L K + +LA + +L L +S+ L+
Sbjct: 1239 EVKV-LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297
Query: 419 LQEQMLGLRLSEAKTEWEGA---ERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIE 472
E+ G++ ++ E ++ L++ R + ++ +R + E+ + L +Q E
Sbjct: 1298 EAEKK-GIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353
Score = 58.2 bits (139), Expect = 2e-08
Identities = 120/525 (22%), Positives = 215/525 (40%), Gaps = 66/525 (12%)
Query: 101 LRELLQV-RARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKR--LVEVR 157
++ LLQV R +LQ + L+ + + E E E + Q L+++ L E
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEME----RKHQQLLEEKNILAEQL 896
Query: 158 EALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQ---EDSS 214
+A T L + A +QE L L +++EE+ ++ +K Q +D
Sbjct: 897 QAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 956
Query: 215 RRVDLEV-ARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMK---ASESSRLK 270
++D E AR + Q+ K+ E ++ ++ E L F+ +K M+ A SS+L
Sbjct: 957 EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016
Query: 271 LE---GSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQN 327
E ++ ++ E + +EERL+ + +E L + + LD L + +
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE--LEKAKRKLDGETTDLQDQIAEL 1074
Query: 328 QASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLRE 387
QA ++ + L K EE G LA E L + +E+ ++ L+E
Sbjct: 1075 QAQIDELKLQLAKK-------EEELQGALARGDDETLHKNNALKVV--RELQAQIAELQE 1125
Query: 388 KSRALEASVAQLAGQLKELSGHLPALSSRL-DLQEQMLGLRLSEAKTEWEGAE-RKSLED 445
+ +AS + Q ++LS L AL + L D + + K E E AE +K+LE+
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 446 LARWRKEVTEHLRGVR-EKVDGLPQQIESVSD-KCLLHKSDSDL---------------R 488
+ + + +R ++ L +Q+E K L K+ L +
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1245
Query: 489 ISAEGKAREFKVGALRQELATLLSS-----VQLLKE--------DNPGRKIAEMQGKLAT 535
+ AE + + K+ A QEL +S V+L ++ DN + E + K
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 536 FQNQIMKLENCVQ------ANKTIQNLRFNTEARLRTQEMATLWE 574
F LE+ +Q +T Q L ++ R +E +L E
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQE 1350
Score = 40.8 bits (94), Expect = 0.004
Identities = 58/279 (20%), Positives = 119/279 (42%), Gaps = 23/279 (8%)
Query: 40 LSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLRE---HKQRCERA 96
+ L++L + E+++ + + K Q++ + EL+ A E + E+
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQ--LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681
Query: 97 TRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEV 156
+SL E+LQ++ + R +QE A A S L ++ + L+ R+ ++
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741
Query: 157 REALTRL---------RRRQVQQEAERRGAEQEAGLRLAKLTDLLQQ--EEQGREVACGA 205
E L R R+ + + AE A A+ +D +Q E Q +E+
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK-AK 1800
Query: 206 LQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASE 265
LQ+ + + ++ ++A++ +L E+ L++EAK K EK++K
Sbjct: 1801 LQELEGAVKSKFKATISALEAKIGQLEEQ-----LEQEAKERAAANKLVRRTEKKLK-EI 1854
Query: 266 SSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEES 304
+++ E + + + EK M++ R L+ EE+
Sbjct: 1855 FMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEA 1893
Score = 30.0 bits (66), Expect = 7.2
Identities = 25/104 (24%), Positives = 53/104 (50%), Gaps = 7/104 (6%)
Query: 71 QLEQWVVELQAEVACLREHKQRCERAT---RSLLRELLQVRARVQLQGSELRQLQQEARP 127
+L++ ++++ E ++K++ E+A + L R+L + + R+LQ+E
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909
Query: 128 AAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQE 171
A +A E + E S L+N++ +R + + +R RRQ+ E
Sbjct: 1910 ATEANEGLSREVSTLKNRL----RRGGPISFSSSRSGRRQLHLE 1949
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 75.1 bits (183), Expect = 2e-13
Identities = 122/500 (24%), Positives = 229/500 (45%), Gaps = 87/500 (17%)
Query: 71 QLEQWVVELQAE---VACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARP 127
+L + + +QA+ V E+K+ ER SLL +RA + ++ +L + +P
Sbjct: 780 RLSRIITRIQAQSRGVLARMEYKKLLERRD-SLLVIQWNIRAFMGVKNWPWMKLYFKIKP 838
Query: 128 AAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAK 187
++ E+E K + ++E TRL+ + EA R+ E+ K
Sbjct: 839 LLKSAERE---------------KEMASMKEEFTRLKEALEKSEARRKELEE-------K 876
Query: 188 LTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVA---RMQAQVTKLGEEVSLRFLKREA 244
+ LLQ E+ ++ A Q N D+ R D + +++A+V ++ E L+ E
Sbjct: 877 MVSLLQ-EKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNER-----LEDEE 930
Query: 245 KLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEES 304
++ + L +KR E S LK + ++ EK + E +++
Sbjct: 931 EM-----NAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVK--------- 976
Query: 305 HLLEQCQGLDAAVAQLTK----FVQQNQASLNRVLLAEEKA---WDAKGRLEESRAGELA 357
+L E+ GLD +A+LTK + +Q +L+ + E+K AK +LE+ + +L
Sbjct: 977 NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ-QVDDLE 1035
Query: 358 AYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRL 417
+++ + ++ E A++++ G+L L +E LE QL +LK+ L AL++R+
Sbjct: 1036 GSLEQE-KKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI 1094
Query: 418 DLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHL---RGVREKVD----GLPQQ 470
+ EQ LG +L +K L++L +E+ E L R R KV+ L ++
Sbjct: 1095 E-DEQALGSQL-----------QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRE 1142
Query: 471 IESVSDKCLLHKSDSDLRISAE-GKAREFKVGALRQEL--ATL---LSSVQLLKEDNPGR 524
+E +S++ L ++ + E K RE + +R++L ATL ++ L K+
Sbjct: 1143 LEEISER--LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH--AD 1198
Query: 525 KIAEMQGKLATFQNQIMKLE 544
+AE+ ++ Q KLE
Sbjct: 1199 SVAELGEQIDNLQRVKQKLE 1218
Score = 45.8 bits (107), Expect = 1e-04
Identities = 99/478 (20%), Positives = 186/478 (38%), Gaps = 89/478 (18%)
Query: 67 KHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRAR---------VQLQGSE 117
K +L+ + EL+ E+ R + + E+ L REL ++ R VQ++ ++
Sbjct: 1106 KKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNK 1165
Query: 118 LRQ--------------LQQEARPAA-----------------------QAPEKEAPEFS 140
R+ LQ EA AA Q EKE EF
Sbjct: 1166 KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1225
Query: 141 GLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGRE 200
+ + + +++++ + L ++ R Q E R +E + DL Q +
Sbjct: 1226 LELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEET---QRSVNDLTSQRAK--- 1279
Query: 201 VACGALQKNQEDSSRRVDLEVARMQAQVT--KLGEEVSLRFLKREAKLCGFLQKSFLALE 258
LQ + SR++D E + +Q+T KL L LKR+ L++ A
Sbjct: 1280 -----LQTENGELSRQLD-EKEALISQLTRGKLTYTQQLEDLKRQ------LEEEVKAKN 1327
Query: 259 KRMKASESSRLK---LEGSLRGELESRWEKLRGLMEERLRALQGQHE-ESHLLEQCQGLD 314
A +S+R L E E++ E R L + Q + + E+ +++ + L+
Sbjct: 1328 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1387
Query: 315 AAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEE---------SRAGELAAYV---QE 362
A +L + +Q+ + ++ V K RL+ R+ AA + Q
Sbjct: 1388 EAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447
Query: 363 NLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALS-SRLDLQE 421
N + + +E EL ++++R+L + +L +E HL +LQE
Sbjct: 1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE 1507
Query: 422 QMLGLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCL 479
++ L TE G+ K++ +L + RK++ ++ ++ +E K L
Sbjct: 1508 EISDL------TEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKIL 1559
Score = 39.3 bits (90), Expect = 0.012
Identities = 81/350 (23%), Positives = 145/350 (41%), Gaps = 65/350 (18%)
Query: 52 SHPTSTASVPEQDTAKHWNQLEQWVVELQAEVAC---LREHKQRCERATRSLLRELLQVR 108
SH A+ ++ + L+ ++L V L+E+ ER L EL ++R
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1689
Query: 109 ARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRL----VEVREALTRLR 164
A V+ + +QE ++ + + + L NQ + +D L EV EA+ R
Sbjct: 1690 AVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECR 1749
Query: 165 RRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARM 224
E + + A +A + +L ++EQ ++KN E + + DL+
Sbjct: 1750 ----NAEEKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNMEQTIK--DLQHRLD 1798
Query: 225 QAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWE 284
+A E+++L+ K++ LQK LE R++ +LE L E + E
Sbjct: 1799 EA------EQIALKGGKKQ------LQK----LEARVR-------ELENELEAEQKRNAE 1835
Query: 285 KLRGL--MEERLRALQGQHEE--SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEK 340
++G+ E R++ L Q EE +LL +D ++ + +Q AEE
Sbjct: 1836 SVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQ----------AEEA 1885
Query: 341 AWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSR 390
A L + R VQ L+ A+ ++A +++ LR KSR
Sbjct: 1886 EEQANTNLSKFRK------VQHELDEAEERADIAESQVN----KLRAKSR 1925
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 74.7 bits (182), Expect = 3e-13
Identities = 123/588 (20%), Positives = 255/588 (43%), Gaps = 81/588 (13%)
Query: 41 SLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSL 100
++EEL + T TA E T Q+E+ ++ Q E+ L +++Q ERA +
Sbjct: 591 AMEELKVSFSKGLGTETAEFAELKT-----QIEKMRLDYQHEIENL-QNQQDSERAAHAK 644
Query: 101 LRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREAL 160
E L+ + ++ E L+ +A ++ E N++Q + ++ E+
Sbjct: 645 EMEALRAKLMKVIKEKE-NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
Query: 161 TRLRRR---------QVQQEAER-------RGAEQEAGLRLAKLTDLLQQEEQGREVACG 204
+ + Q++ E+ R A E + KL L+ E +++
Sbjct: 704 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE--KQIKHL 761
Query: 205 ALQKNQEDS-SRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKA 263
++KN E S + + E+ + ++T L E +S +E L+K L+++
Sbjct: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET-----LEKELQILKEKFAE 816
Query: 264 SESSRLKLEGSLR-------------GELESRWEKLR-GLMEERLRALQGQHEESHLLEQ 309
+ + ++ S++ L S EKLR L + + + E L++
Sbjct: 817 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 876
Query: 310 CQGLDAAVAQLTKFVQQNQASLNRV---LLAEEKAWDAKGRLEESRAGELAAYVQENLEA 366
+ L+ +A++ K N + L ++ L +E+ + +L+ ++A E A+++Q+++E
Sbjct: 877 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEEL-QLKLTKANENASFLQKSIED 935
Query: 367 AQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGL 426
+ E ++QE + E+ + LE ++ L +++ L +R +
Sbjct: 936 MTVKAEQSQQEAAKKH---EEEKKELERKLSDLEKKMETSHNQCQELKARYERAT----- 987
Query: 427 RLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESV---SDKCLLHKS 483
SE KT+ E + L++L + + + L+G RE+ GL Q++E + +DK ++
Sbjct: 988 --SETKTKHE----EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQT 1041
Query: 484 DSDLRISAEGKARE-----FKVGALRQELATLLSSVQLLKEDNPGRKIAEM--QGKLATF 536
D E +E + +Q A L + + LKE+N + + E+ +L T
Sbjct: 1042 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL-KNVEELNKSKELLTV 1100
Query: 537 QNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEG 584
+NQ M+ + K I+ L+ A ++Q+++ L E ++L E G
Sbjct: 1101 ENQKME-----EFRKEIETLK--QAAAQKSQQLSALQEENVKLAEELG 1141
Score = 62.8 bits (151), Expect = 1e-09
Identities = 120/571 (21%), Positives = 247/571 (43%), Gaps = 56/571 (9%)
Query: 38 EPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERAT 97
E L E ER E + TS EQ+ A + +Q V+EL+A++ LR + +R
Sbjct: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
Query: 98 RSLLRELLQVRARVQLQGSELR-QLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEV 156
LL +L + + +V+ +L+ ++++E+ E S + + L R+ EV
Sbjct: 425 VELLNQLEEEKRKVE----DLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEV 480
Query: 157 REALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQE------EQGREVAC-----GA 205
E LRRR E+ + + + L L + LQ++ + RE+ GA
Sbjct: 481 AE----LRRR---LESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA 533
Query: 206 LQKNQE-------DSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALE 258
++ + ++ ++ E +++++ +E S ++KL + A+E
Sbjct: 534 REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME 593
Query: 259 KRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVA 318
+ +K S S L E + EL+++ EK+R + + LQ Q ++S + ++A A
Sbjct: 594 E-LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQ-QDSERAAHAKEMEALRA 651
Query: 319 QLTKFVQQNQASLNRVLLAEEKAWD-----AKGRLEESRAGELAAYVQENLEAAQLAGEL 373
+L K +++ + SL + +KA D + L + + E+ E L+A
Sbjct: 652 KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 711
Query: 374 ARQEMHGELVLLREKSRALEA---SVAQLAGQLKELSGHLPALSSR---LDLQEQMLGLR 427
+L EK L+A + ++ ++K+L L A + L++++ +
Sbjct: 712 VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 771
Query: 428 LSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCL-LHKSDSD 486
S E +G E K L +L EV++ + +++ L ++ S++ + + +S +
Sbjct: 772 ASSITRELQGRELK-LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 830
Query: 487 LRISAEGKAREFK-----VGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIM 541
K +F + LR+ LA + + ++D ++ + + KL +IM
Sbjct: 831 TVNKLHQKEEQFNMLSSDLEKLRENLADM--EAKFREKDEREEQLIKAKEKLENDIAEIM 888
Query: 542 KLENCVQANKTIQNLRFNTEARLRTQEMATL 572
K+ + + Q + N E RL+ +++ L
Sbjct: 889 KM----SGDNSSQLTKMNDELRLKERDVEEL 915
Score = 51.6 bits (122), Expect = 2e-06
Identities = 109/519 (21%), Positives = 210/519 (40%), Gaps = 71/519 (13%)
Query: 78 ELQAEVACLREHKQRCERATRSLLRELLQVRARV-----QLQGSELR--QLQQEARPAAQ 130
E ++E+ LR+ + E+ + L E ++ +LQG EL+ LQ+ +Q
Sbjct: 739 EGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 798
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTD 190
E E L+ + + V V+ ++ + Q+E + + L D
Sbjct: 799 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 858
Query: 191 L---LQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRF-------- 239
+ +++++ E A +K + D + + + +Q+TK+ +E+ L+
Sbjct: 859 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMS-GDNSSQLTKMNDELRLKERDVEELQL 917
Query: 240 -LKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQ 298
L + + FLQKS + +KA +S + E + E+ + +E +L L+
Sbjct: 918 KLTKANENASFLQKSIE--DMTVKAEQSQQ---------EAAKKHEEEKKELERKLSDLE 966
Query: 299 GQHEESHLLEQCQGLDAAVAQLTKFVQQNQA----SLNRVLL-AEEKAWDAK----GRLE 349
+ E SH QCQ L A + T + +L + LL E+K A+ G L+
Sbjct: 967 KKMETSH--NQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ 1024
Query: 350 E----SRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKE 405
E + + A Q +A Q+ ++ +++ E + E ++ A + LKE
Sbjct: 1025 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT--ETLASLEDTKQTNAKLQNELDTLKE 1082
Query: 406 LS----GHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKS-------------LEDLAR 448
+ L L ++ Q + E +T + A +KS E+L R
Sbjct: 1083 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1142
Query: 449 WRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQ--- 505
R EVT H + + E+ L Q+ + + D+D ++ K+ L +
Sbjct: 1143 SRDEVTSHQK-LEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDA 1201
Query: 506 ELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLE 544
EL L + V +L+ +N K + + T ++ +KLE
Sbjct: 1202 ELEKLRNEVTVLRGENASAK--SLHSVVQTLESDKVKLE 1238
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 74.7 bits (182), Expect = 3e-13
Identities = 123/588 (20%), Positives = 255/588 (43%), Gaps = 81/588 (13%)
Query: 41 SLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSL 100
++EEL + T TA E T Q+E+ ++ Q E+ L +++Q ERA +
Sbjct: 626 AMEELKVSFSKGLGTETAEFAELKT-----QIEKMRLDYQHEIENL-QNQQDSERAAHAK 679
Query: 101 LRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREAL 160
E L+ + ++ E L+ +A ++ E N++Q + ++ E+
Sbjct: 680 EMEALRAKLMKVIKEKE-NSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 738
Query: 161 TRLRRR---------QVQQEAER-------RGAEQEAGLRLAKLTDLLQQEEQGREVACG 204
+ + Q++ E+ R A E + KL L+ E +++
Sbjct: 739 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE--KQIKHL 796
Query: 205 ALQKNQEDS-SRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKA 263
++KN E S + + E+ + ++T L E +S +E L+K L+++
Sbjct: 797 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET-----LEKELQILKEKFAE 851
Query: 264 SESSRLKLEGSLR-------------GELESRWEKLR-GLMEERLRALQGQHEESHLLEQ 309
+ + ++ S++ L S EKLR L + + + E L++
Sbjct: 852 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 911
Query: 310 CQGLDAAVAQLTKFVQQNQASLNRV---LLAEEKAWDAKGRLEESRAGELAAYVQENLEA 366
+ L+ +A++ K N + L ++ L +E+ + +L+ ++A E A+++Q+++E
Sbjct: 912 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEEL-QLKLTKANENASFLQKSIED 970
Query: 367 AQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGL 426
+ E ++QE + E+ + LE ++ L +++ L +R +
Sbjct: 971 MTVKAEQSQQEAAKKH---EEEKKELERKLSDLEKKMETSHNQCQELKARYERAT----- 1022
Query: 427 RLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESV---SDKCLLHKS 483
SE KT+ E + L++L + + + L+G RE+ GL Q++E + +DK ++
Sbjct: 1023 --SETKTKHE----EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQT 1076
Query: 484 DSDLRISAEGKARE-----FKVGALRQELATLLSSVQLLKEDNPGRKIAEM--QGKLATF 536
D E +E + +Q A L + + LKE+N + + E+ +L T
Sbjct: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL-KNVEELNKSKELLTV 1135
Query: 537 QNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEG 584
+NQ M+ + K I+ L+ A ++Q+++ L E ++L E G
Sbjct: 1136 ENQKME-----EFRKEIETLK--QAAAQKSQQLSALQEENVKLAEELG 1176
Score = 63.2 bits (152), Expect = 8e-10
Identities = 121/556 (21%), Positives = 241/556 (43%), Gaps = 60/556 (10%)
Query: 38 EPLSLEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERAT 97
E L E ER E + TS EQ+ A + +Q V+EL+A++ LR + +R
Sbjct: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
Query: 98 RSLLRELLQVRARVQLQGSELR-QLQQEARPAAQAPEKEAPEFSGLQNQMQAL---DKRL 153
LL +L + + +V+ +L+ ++++E+ + E + ++ Q+L +
Sbjct: 425 VELLNQLEEEKRKVE----DLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKA 480
Query: 154 VEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREV--ACGALQKNQE 211
+++ L R V +++ E++ LR+ ++ +L ++ E + +L QE
Sbjct: 481 DKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 540
Query: 212 DSSRRVDLEVARM--QAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRL 269
SS + LEV R Q ++T L E F RE ++ + A EK K +ES +
Sbjct: 541 ISSLQEKLEVTRTDHQREITSLKE----HFGAREETHQKEIKALYTATEKLSKENESLKS 596
Query: 270 KLEGSLRGELESRWEKLRGLMEERLRALQGQHE---ESHLLEQCQGLDAAVAQLTKFVQQ 326
KLE + + + + L + +L H+ E + +GL A+ + Q
Sbjct: 597 KLEHANKENSD-----VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 651
Query: 327 NQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLR 386
+ ++ L + + L+ + E AA+ +E +EA + +E L +R
Sbjct: 652 ----IEKMRLDYQHEIE---NLQNQQDSERAAHAKE-MEALRAKLMKVIKEKENSLEAIR 703
Query: 387 EK-SRALEASVAQLAGQLKELS------GHLPALSSRLDLQEQMLGLRLSEAKTEWEGAE 439
K +A + + ++ L +L L L ++ + Q +++ S+ K A
Sbjct: 704 SKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLK-----AT 758
Query: 440 RKSLEDLARWRKEVTE---HLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAR 496
+ L DL RK +E ++ +R++++ +QI+ + + S + I+ E + R
Sbjct: 759 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS-SITRELQGR 817
Query: 497 EFKVGALRQELA-------TLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQA 549
E K+ L++ L+ TL +Q+LKE K AE + + Q + + N +
Sbjct: 818 ELKLTNLQENLSEVSQVKETLEKELQILKE-----KFAEASEEAVSVQRSMQETVNKLHQ 872
Query: 550 NKTIQNLRFNTEARLR 565
+ N+ + +LR
Sbjct: 873 KEEQFNMLSSDLEKLR 888
Score = 51.6 bits (122), Expect = 2e-06
Identities = 109/519 (21%), Positives = 210/519 (40%), Gaps = 71/519 (13%)
Query: 78 ELQAEVACLREHKQRCERATRSLLRELLQVRARV-----QLQGSELR--QLQQEARPAAQ 130
E ++E+ LR+ + E+ + L E ++ +LQG EL+ LQ+ +Q
Sbjct: 774 EGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 833
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTD 190
E E L+ + + V V+ ++ + Q+E + + L D
Sbjct: 834 VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 893
Query: 191 L---LQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRF-------- 239
+ +++++ E A +K + D + + + +Q+TK+ +E+ L+
Sbjct: 894 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMS-GDNSSQLTKMNDELRLKERDVEELQL 952
Query: 240 -LKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQ 298
L + + FLQKS + +KA +S + E + E+ + +E +L L+
Sbjct: 953 KLTKANENASFLQKSIE--DMTVKAEQSQQ---------EAAKKHEEEKKELERKLSDLE 1001
Query: 299 GQHEESHLLEQCQGLDAAVAQLTKFVQQNQA----SLNRVLL-AEEKAWDAK----GRLE 349
+ E SH QCQ L A + T + +L + LL E+K A+ G L+
Sbjct: 1002 KKMETSH--NQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ 1059
Query: 350 E----SRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKE 405
E + + A Q +A Q+ ++ +++ E + E ++ A + LKE
Sbjct: 1060 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT--ETLASLEDTKQTNAKLQNELDTLKE 1117
Query: 406 LS----GHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKS-------------LEDLAR 448
+ L L ++ Q + E +T + A +KS E+L R
Sbjct: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
Query: 449 WRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQ--- 505
R EVT H + + E+ L Q+ + + D+D ++ K+ L +
Sbjct: 1178 SRDEVTSHQK-LEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDA 1236
Query: 506 ELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLE 544
EL L + V +L+ +N K + + T ++ +KLE
Sbjct: 1237 ELEKLRNEVTVLRGENASAK--SLHSVVQTLESDKVKLE 1273
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 74.7 bits (182), Expect = 3e-13
Identities = 121/511 (23%), Positives = 209/511 (40%), Gaps = 59/511 (11%)
Query: 86 LREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQ 145
L E + R + + +L + A + Q + Q+Q+ + ++ EF G + +
Sbjct: 624 LTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERER 683
Query: 146 MQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGA 205
+Q + + + L +++ +Q++ + +QE L L K L Q+ Q RE + A
Sbjct: 684 LQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQE-HLDLMKQLTLTQEALQSREQSLDA 742
Query: 206 LQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASE 265
LQ + ++ +QA++ +L E + RE +C LQ + LE ++A++
Sbjct: 743 LQTHYDE-----------LQARLGELQGEAA----SREDTIC-LLQNEKIILEAALQAAK 786
Query: 266 SSRLKLEGSLRGELESRWEKLRGLME---ERLRALQGQHEESHLLEQCQGLDAAVAQLTK 322
S + +L+ R LE E+ +E E L GQ E HL ++ L Q+ K
Sbjct: 787 SGKEELDRGAR-RLEEGTEETSETLEKLREELAIKSGQVE--HLQQETAALK---KQMQK 840
Query: 323 FVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQE-NLEAAQLAGELARQEMHGE 381
+Q L + ++ E DA + + EL A + + E +L EL ++HGE
Sbjct: 841 IKEQ---FLQQKVMVEAYRRDATSK--DQLISELKATRKRLDSELKELRQEL--MQVHGE 893
Query: 382 LVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLD-----LQEQMLGLRLSEAKTEWE 436
+ L VAQ+ + +L GHL + D LQ A TE
Sbjct: 894 KRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEAN 953
Query: 437 GAERKSLEDLAR-WRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKA 495
A +K +E+L + RK +TE ++K+ L + S + + + KA
Sbjct: 954 EALKKQIEELQQEARKAITEQ----KQKMRRLGSDLTSAQKE-----------MKTKHKA 998
Query: 496 REFKVGALRQELATLLSSVQLL-KEDNPGRKIAEMQGKLATFQNQIMKLENCVQA---NK 551
E VG L + L L++ + E R +I LE +QA +K
Sbjct: 999 YENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSK 1058
Query: 552 TIQNLRFNTEARLRTQEMATLWESVLRLWSE 582
T+ L +QE+ E VL L E
Sbjct: 1059 TLLEKELQEVIALTSQELEESREKVLELEDE 1089
Score = 67.4 bits (163), Expect = 4e-11
Identities = 115/511 (22%), Positives = 214/511 (41%), Gaps = 82/511 (16%)
Query: 86 LREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQ----------APEKE 135
L+ ++R + + L +EL+QV + +EL +L +E Q + +KE
Sbjct: 869 LKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKE 928
Query: 136 APEFSGLQNQMQALDKRLVEVREALTRLRRR--QVQQEAERRGAEQEAGLR-----LAKL 188
E +Q +++V V EA L+++ ++QQEA + EQ+ +R L
Sbjct: 929 RDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSA 988
Query: 189 TDLLQQEEQGREVACGALQKNQED---SSRRVDLEVARMQAQVTKLGEEVSL--RFLKRE 243
++ + + E A G L + ++ + D E+ +++AQ ++L R E
Sbjct: 989 QKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALE 1048
Query: 244 AKLCGF----------LQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEER 293
A+L LQ+ + ++ S L+LE L+ E +K++ L E
Sbjct: 1049 AELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQ-ESRGFRKKIKRLEESN 1107
Query: 294 LR-ALQGQHEESHLL----------EQCQGLDAAVAQLTKFVQQNQASLNRVLLAEE--- 339
+ AL+ +HE+ L E L+ A+A+ + Q + VL +E
Sbjct: 1108 KKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEED 1167
Query: 340 -------KAWDAKGRLEESRAGEL----------AAYVQENLEAAQL----------AGE 372
+A A E+ + L A + + + +AA L A E
Sbjct: 1168 RQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKE 1227
Query: 373 LARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLD--LQEQMLGLRLSE 430
Q++ E L+ + +AQ +L E L L +LD L +Q +G + E
Sbjct: 1228 HLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEME 1287
Query: 431 AKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRIS 490
+WE +++ + + ++TE + R++++GL Q +++V K L + DL ++
Sbjct: 1288 -NLKWEVDQKEREIQSLKQQLDLTE--QQGRKELEGLQQLLQNV--KSELEMAQEDLSMT 1342
Query: 491 AEGK-AREFKVGALRQELATLLSSVQLLKED 520
+ K + KV L+ + TLL Q LK D
Sbjct: 1343 QKDKFMLQAKVSELKNNMKTLLQQNQQLKLD 1373
Score = 53.5 bits (127), Expect = 6e-07
Identities = 107/505 (21%), Positives = 204/505 (40%), Gaps = 69/505 (13%)
Query: 72 LEQWVVELQAEVACLREHKQRCERATRSL-------LRELLQVRARVQLQGSELRQLQQE 124
LE E Q E+ + + K R E +L L+E +++A++ ++L+ +
Sbjct: 396 LESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVEC 455
Query: 125 ARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLR 184
+ + Q + + E L+ L++ + +++ L + + AE++
Sbjct: 456 SHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRL 515
Query: 185 LAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREA 244
+AK+ D+ + L K+ R + + Q Q +L LK
Sbjct: 516 MAKVEDMQR----------SMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565
Query: 245 KLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEE--------RLRA 296
LQ ++++ ++ +R++L+G + ++ GL+E +
Sbjct: 566 AEISSLQSVRQWYQQQLALAQEARVRLQGEM-AHIQVGQMTQAGLLEHLKLENVSLSQQL 624
Query: 297 LQGQH----EESHLLEQCQGLDA-AVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEE- 350
+ QH E+ + Q QG++A + Q F+Q +A + EE D + RLEE
Sbjct: 625 TETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAK----TMVEE---DLQRRLEEF 677
Query: 351 -------SRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQL 403
R + AA +++ LE +L L +++ E + + ++ Q A Q
Sbjct: 678 EGERERLQRMADSAASLEQQLEQVKLT--LLQRDQQLEALQQEHLDLMKQLTLTQEALQS 735
Query: 404 KELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGA-----ERKSLEDLARWRKEVTEHL- 457
+E S L AL + D + LG EA + + E+ LE + K E L
Sbjct: 736 REQS--LDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELD 793
Query: 458 RGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLL 517
RG R +G + E+ L K +L I + +V L+QE A L +Q +
Sbjct: 794 RGARRLEEGTEETSET------LEKLREELAI------KSGQVEHLQQETAALKKQMQKI 841
Query: 518 KEDNPGRKI-AEMQGKLATFQNQIM 541
KE +K+ E + AT ++Q++
Sbjct: 842 KEQFLQQKVMVEAYRRDATSKDQLI 866
Score = 30.8 bits (68), Expect = 4.2
Identities = 48/212 (22%), Positives = 81/212 (38%), Gaps = 23/212 (10%)
Query: 70 NQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAA 129
N L++ V + E R H + + +EL VQ +E LQ +
Sbjct: 1189 NSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHS 1248
Query: 130 QAPEKEAPEFSGLQNQMQALDKRLVEV-------REALTRLRRRQVQQEAERRGAEQEAG 182
Q + E + + Q+Q L K+L E + + L+ Q+E E + +Q+
Sbjct: 1249 QEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLD 1308
Query: 183 L-------RLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEV 235
L L L LLQ + E+A L Q+D +QA+V++L +
Sbjct: 1309 LTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKDK--------FMLQAKVSELKNNM 1360
Query: 236 SLRFLKREAKLCGFLQKSFLALEKRMKASESS 267
L++ +L L++ K K SS
Sbjct: 1361 K-TLLQQNQQLKLDLRRGAAKTRKEPKGEASS 1391
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 72.4 bits (176), Expect = 1e-12
Identities = 113/466 (24%), Positives = 206/466 (44%), Gaps = 72/466 (15%)
Query: 36 SPEPLSL-EELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCE 94
S EP++ E+LSE + + A V EQD +H + +Q ++ E C E +
Sbjct: 577 STEPVAPPEQLSEAALKAMEEAVAQVLEQDQ-RHLLESKQEKMQQLREKLCQEEEE---- 631
Query: 95 RATRSLLRELLQVRARVQLQGSELRQLQQEA--RPAAQAPEKEAPEFSGLQNQMQAL--- 149
E+L++ + + S LR+ Q+A A+ E+E+ S L+ Q+Q+
Sbjct: 632 --------EILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA 683
Query: 150 --DKRLVEVREALTRLRRR-QVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL 206
D+ E +L +LR + QQ+AER EQ+ L +L + ++ E+ + A A
Sbjct: 684 DEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNA- 742
Query: 207 QKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRM-KASE 265
K + R LE R +A V L +E S + + L ++ +L+K++ +A +
Sbjct: 743 AKEKALQQLREQLEGERKEA-VATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ 801
Query: 266 SSRLKLEGSLRGELESR-----------WEKLRGLMEERLRALQGQHEESHLLEQCQGLD 314
+L+ L G++E R +L L+ E+ + ++G+HE
Sbjct: 802 KEEAQLQKCL-GQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHER----------- 849
Query: 315 AAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAG--- 371
+L K +++Q +V+ + ++A+ E + EL ++ LE Q A
Sbjct: 850 ----RLDKMKEEHQ----QVMAKAREQYEAE---ERKQRAELLGHLTGELERLQRAHERE 898
Query: 372 -ELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQE--------Q 422
E RQE H L LR + R E + L L+ + + A + L++QE Q
Sbjct: 899 LETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQ 958
Query: 423 MLGLRLSEA-KTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGL 467
+L ++ A K+E A + LE+ + + + + +RE +D L
Sbjct: 959 LLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDEL 1004
Score = 41.2 bits (95), Expect = 0.003
Identities = 58/270 (21%), Positives = 111/270 (41%), Gaps = 27/270 (10%)
Query: 258 EKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAV 317
EK + E L+L L S E+L+ +EE ++ + + + Q +
Sbjct: 623 EKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQ 682
Query: 318 AQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQE 377
A + + +ASL ++ E A+ E + ++ ++E +EA++ + + A
Sbjct: 683 ADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAA--- 739
Query: 378 MHGELVLLREKSRALEASVAQLAGQLKEL--------SGHLPALSSRLDLQEQ----MLG 425
L K +AL+ QL G+ KE S L L S L+ + + L
Sbjct: 740 ------LNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQ 793
Query: 426 LRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGL----PQQIESVSDKCLLH 481
++ EA+ + E +K L + + + H+ G ++ L Q++E ++ L
Sbjct: 794 KKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDK 853
Query: 482 KSDSDLRISAEGKAREFKVGALRQELATLL 511
+ ++ A KARE R++ A LL
Sbjct: 854 MKEEHQQVMA--KAREQYEAEERKQRAELL 881
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 72.0 bits (175), Expect = 2e-12
Identities = 116/516 (22%), Positives = 212/516 (41%), Gaps = 67/516 (12%)
Query: 78 ELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEK--E 135
+LQA V L + + E LL E Q S + LQ +QA E+ +
Sbjct: 431 QLQARVEMLETERGQQEA---KLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQ 487
Query: 136 APEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQE 195
A + G + L ++ + LT L QQ+ E G +Q+A + A+L LQQ+
Sbjct: 488 ASQAHGAR-----LTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQ 542
Query: 196 EQGR-------EVACGALQKNQEDSSRRVDLEVARMQAQVTKLG-----EEVSLRFLKRE 243
EQ E +L++ ++ + + A Q +L E SLR
Sbjct: 543 EQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAA 602
Query: 244 AKLCGFLQKSFLA----LEKRMKASESSRLKLEGSL------RGELESRWEKLRGLMEER 293
K L+K A L+++++ + +R + S+ + EL + E+L+ +E
Sbjct: 603 LKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE-- 660
Query: 294 LRALQGQHEE----SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLE 349
A Q QHE + L Q + + + Q+ ++ +E KG LE
Sbjct: 661 -TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLE 719
Query: 350 ESRAGELAAYVQENLEAAQLAGE---LARQEMHGELVLLREKS--RALEASVAQLAGQLK 404
E + A ++ ++L E L Q L E++ + LEA + QL G+
Sbjct: 720 EEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQL-GEAH 778
Query: 405 ELSGHLPALSSRLDLQEQMLGLRLSEAKTE--------WEGAERKSLEDLARWRKEVTEH 456
+ + R +L E M +E++ E W S ++ A++ E
Sbjct: 779 QAETEV----LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQ 834
Query: 457 LRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQL 516
L ++E+ + Q+++ +K +S S+L+IS + + ++ L LA L VQ
Sbjct: 835 LMTLKEECEKARQELQEAKEKVAGIESHSELQISRQ----QNELAELHANLARALQQVQ- 889
Query: 517 LKEDNPGRKIAE----MQGKLATFQNQIMKLENCVQ 548
+++ +K+A+ +Q K+A ++ +LE V+
Sbjct: 890 -EKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
Score = 71.2 bits (173), Expect = 3e-12
Identities = 138/564 (24%), Positives = 234/564 (41%), Gaps = 71/564 (12%)
Query: 47 ERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERA-----TRSLL 101
ERYE S +Q+ A++ ++ ++ L+ E R+ Q + + S L
Sbjct: 815 ERYEDS---------QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSEL 865
Query: 102 RELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALT 161
+ Q +L + R LQQ +A +K A + S LQ +M A K EV T
Sbjct: 866 QISRQQNELAELHANLARALQQVQEKEVRA-QKLADDLSTLQEKMAATSK---EVARLET 921
Query: 162 RLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGRE-----VACGALQKNQEDSSRR 216
+R+ QQE R +E + + L+ E+QGR+ A A+++ E
Sbjct: 922 LVRKAGEQQETASRELVKEPARAGDRQPEWLE-EQQGRQFCSTQAALQAMEREAEQMGNE 980
Query: 217 VD-LEVARMQAQVTKLGEEVSL-RFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGS 274
++ L A M++Q + E R + R + G Q LALEK ++R +LE
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQAD-LALEK------AARAELEMR 1033
Query: 275 LRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRV 334
L+ L + + L E AL + + L + +GL+AA + + ++Q L
Sbjct: 1034 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQ 1093
Query: 335 LLAEEKAW--------DAKGRLE------ESRAGELAAYVQENLEAAQLAGELARQEMHG 380
L +EK +A GR E E+ E++ Q+ + + A L R +
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLER-SLEA 1152
Query: 381 ELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRL-----SEAKTEW 435
E E+ ALE QL + +EL AL+S Q ++ R S+A+ EW
Sbjct: 1153 ERASRAERDSALETLQGQLEEKAQELGHSQSALAS---AQRELAAFRTKVQDHSKAEDEW 1209
Query: 436 EG--------AERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIES--VSDKCLLHKSDS 485
+ AERK+ ++ +EV+ R V EK +G ++++ +++ K +
Sbjct: 1210 KAQVARGRQEAERKN-SLISSLEEEVSILNRQVLEK-EGESKELKRLVMAESEKSQKLEE 1267
Query: 486 DLRISAEGKAREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLEN 545
LR+ A A R + L VQ L+E+ +++A + +Q + E
Sbjct: 1268 RLRLLQAETASNSARAAERS--SALREEVQSLREEAEKQRVAS-ENLRQELTSQAERAEE 1324
Query: 546 CVQANKTIQNLRFNTEARLRTQEM 569
Q K Q F E L T ++
Sbjct: 1325 LGQELKAWQEKFFQKEQALSTLQL 1348
Score = 64.3 bits (155), Expect = 3e-10
Identities = 124/540 (22%), Positives = 210/540 (38%), Gaps = 88/540 (16%)
Query: 44 ELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRE 103
EL R E T V Q+ + QL+ L+ L E K+R A R
Sbjct: 677 ELQLRSEQQKATEKERVA-QEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRC 735
Query: 104 LLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRL 163
+ +++A E R L ++ + + E+E GL+ ++Q +L E +A T +
Sbjct: 736 ISELKA-------ETRSLVEQHKRERKELEEERAGRKGLEARLQ----QLGEAHQAETEV 784
Query: 164 RRRQV--------------------------------QQEAERRGAEQEAGLRLAKLTDL 191
RR++ Q+EA+ QE + L + +
Sbjct: 785 LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEK 844
Query: 192 LQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQ 251
+QE Q + ++ + E R E+A + A + + ++V + ++ + L
Sbjct: 845 ARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQK-----LA 899
Query: 252 KSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQ 311
L+++M A+ +LE +R E + R L++E RA Q E LE+ Q
Sbjct: 900 DDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPE---WLEEQQ 956
Query: 312 GLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAG 371
G QA+L + E +A LE RA + + Q+ E Q
Sbjct: 957 GRQFC---------STQAALQAM---EREAEQMGNELERLRAALMESQGQQQEERGQQER 1004
Query: 372 ELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEA 431
E+AR L +E+ RA +A +A EL L + ++ L L+ A
Sbjct: 1005 EVAR--------LTQERGRA-QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHA 1055
Query: 432 KTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISA 491
TE EG + ++LA+ R ++ + E + Q E ++ K H S S + A
Sbjct: 1056 LTEKEGKD----QELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA 1111
Query: 492 EGKAREF--KVGALRQELATLLSSVQLLKE--DNPGRKI-------AEMQGKLATFQNQI 540
G+ K+ ALR E++ L Q +E D+ R + AE L T Q Q+
Sbjct: 1112 AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQL 1171
Score = 55.5 bits (132), Expect = 2e-07
Identities = 127/555 (22%), Positives = 220/555 (39%), Gaps = 88/555 (15%)
Query: 43 EELSERYESSHPTSTASVPEQDTAKHW--NQLEQWVVELQAEVACLREHKQRCERATRSL 100
+E ++ E S AS E+D+A QLE+ EL H Q A S
Sbjct: 1140 QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELG--------HSQS---ALASA 1188
Query: 101 LRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREAL 160
REL R +VQ + + + Q E++ S L+ ++ L+++++E +E
Sbjct: 1189 QRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE-KEGE 1247
Query: 161 TRLRRRQVQQEAER--------------------RGAEQEAGLRLAKLTDLLQQEEQGRE 200
++ +R V E+E+ R AE+ + LR + L++E + +
Sbjct: 1248 SKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALR--EEVQSLREEAEKQR 1305
Query: 201 VACGALQKNQEDSSRRVDLEVARMQAQVTKLGE-EVSLRFLKREAKLCGFLQKSFLALEK 259
VA L++ + R + ++A K + E +L L+ E L L +
Sbjct: 1306 VASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKH 1365
Query: 260 RMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQ 319
+ ++ + E R ELE + GL E LRA Q E L+ L VA+
Sbjct: 1366 LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRA---QRELGELIP----LRQKVAE 1418
Query: 320 LTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMH 379
+ QQ L AE+ ++ + + + G LA +EN + A L RQ +
Sbjct: 1419 QERTAQQ--------LRAEKASYAEQLSMLKKAHGLLA---EENRGLGERA-NLGRQFLE 1466
Query: 380 GELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAE 439
EL REK V +LA + L + + + Q L ++EGA+
Sbjct: 1467 VELDQAREK------YVQELAAVRADAETRL----AEVQREAQSTARELEVMTAKYEGAK 1516
Query: 440 RKSLEDLARW---RKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEG-KA 495
K LE+ R+ R+++T + + +Q+E +S K L SD ++ + KA
Sbjct: 1517 VKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK--LADSDQASKVQQQKLKA 1574
Query: 496 REFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKL----------------ATFQNQ 539
+ + G +QE L + + L+ ++ A KL Q Q
Sbjct: 1575 VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQ 1634
Query: 540 IMKLENCVQANKTIQ 554
+ LE + NK ++
Sbjct: 1635 LRSLEQLQKENKELR 1649
Score = 53.1 bits (126), Expect = 8e-07
Identities = 109/451 (24%), Positives = 181/451 (40%), Gaps = 64/451 (14%)
Query: 62 EQDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQL 121
+ +TA + + + L+ EV LRE ++ A+ +L +EL R + G EL+
Sbjct: 1273 QAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAW 1332
Query: 122 QQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERR----GA 177
Q++ QA E QAL L+ + +L+ Q E R +
Sbjct: 1333 QEKFFQKEQALSTLQLE----HTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388
Query: 178 EQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSL 237
+Q AG A+L L Q E G + QE +++++ E A Q++ L + L
Sbjct: 1389 KQAAGGLRAEL--LRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGL 1446
Query: 238 RFLKREAKLCG---FLQKSFLALE------------KRMKASESSRL----KLEGSLRGE 278
L E + G L + FL +E ++A +RL + S E
Sbjct: 1447 --LAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARE 1504
Query: 279 LESRWEKLRG----LMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASL--- 331
LE K G ++EER R Q E L Q + L+ + TK V++ L
Sbjct: 1505 LEVMTAKYEGAKVKVLEERQRF---QEERQKLTAQVEQLEVFQREQTKQVEELSKKLADS 1561
Query: 332 ---NRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLR-E 387
++V + KA A+G + A L A + E L +L+++E E L+ E
Sbjct: 1562 DQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNE------LQAQLSQKEQAAEHYKLQME 1615
Query: 388 KSR----ALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSL 443
K++ A + +L QL+ L L + L + + LG L +A G + K
Sbjct: 1616 KAKTHYDAKKQQNQELQEQLRSLE-QLQKENKELRAEAERLGHELQQA-----GLKTKEA 1669
Query: 444 EDLARWRKEVTEHLRGVREKVDGLPQQIESV 474
E R +T +R + +V QQ+ +
Sbjct: 1670 EQTCR---HLTAQVRSLEAQVAHADQQLRDL 1697
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 69.3 bits (168), Expect = 1e-11
Identities = 114/488 (23%), Positives = 223/488 (45%), Gaps = 77/488 (15%)
Query: 90 KQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQN----- 144
+ R ER +R + R +Q +AR QL E +++ E R A + F G++N
Sbjct: 777 EMRDERLSRIITR--MQAQARGQLMRIEFKKIV-ERRDALLVIQWNIRAFMGVKNWPWMK 833
Query: 145 ---------QMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQE 195
+ +K + ++E R++ + EA R+ E+ K+ LLQ E
Sbjct: 834 LYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEE-------KMVSLLQ-E 885
Query: 196 EQGREVACGALQKNQEDSSRRVDLEVA---RMQAQVTKLGEEVSLRFLKREAKLCGFLQK 252
+ ++ A Q N D+ R D + +++A+V ++ E L+ E ++
Sbjct: 886 KNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNER-----LEDEEEM-----N 935
Query: 253 SFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQG 312
+ L +KR E S LK + ++ EK + E +++ +L E+ G
Sbjct: 936 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK---------NLTEEMAG 986
Query: 313 LDAAVAQLTK----FVQQNQASLNRVLLAEEKAWD-AKGRLE-ESRAGELAAYVQENLEA 366
LD +A+LTK + +Q +L+ + + E+K +K +++ E + +L +++ +
Sbjct: 987 LDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQE-KK 1045
Query: 367 AQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGL 426
++ E A++++ G+L L +E LE QL +LK+ + +S+++ EQ+L L
Sbjct: 1046 VRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIE-DEQVLAL 1104
Query: 427 RLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVD----GLPQQIESVSDKCLLHK 482
+L + E + +E+L +E E R R KV+ L +++E +S++ L +
Sbjct: 1105 QLQKKLKE----NQARIEEL----EEELEAERTARAKVEKLRSDLSRELEEISER--LEE 1154
Query: 483 SDSDLRISAE-GKAREFKVGALRQEL--ATL---LSSVQLLKEDNPGRKIAEMQGKLATF 536
+ + E K RE + +R++L ATL ++ L K+ +AE+ ++
Sbjct: 1155 AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH--ADSVAELGEQIDNL 1212
Query: 537 QNQIMKLE 544
Q KLE
Sbjct: 1213 QRVKQKLE 1220
Score = 54.7 bits (130), Expect = 3e-07
Identities = 115/563 (20%), Positives = 232/563 (41%), Gaps = 82/563 (14%)
Query: 72 LEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQA 131
L + + L +A L + K+ + A + L +L +V +L+Q+ +
Sbjct: 980 LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGS 1039
Query: 132 PEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDL 191
E+E L+ + L+ L +E++ L ++Q E + + E + + +K+ D
Sbjct: 1040 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIED- 1098
Query: 192 LQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRF-LKREAKLCGFL 250
+V LQK +++ R++ ++A+ T + LR L RE +
Sbjct: 1099 -------EQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEIS-- 1149
Query: 251 QKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEE-------RLRALQGQHEE 303
E+ +A ++ +++E + + E+ ++K+R +EE AL+ +H +
Sbjct: 1150 -------ERLEEAGGATSVQIE--MNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1200
Query: 304 S--HLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLE------ESRAGE 355
S L EQ L +L K + + L+ V E+ AK LE E +A E
Sbjct: 1201 SVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANE 1260
Query: 356 LAAYVQE--------NLEAAQLA---GELARQEMHGELVL--LREKSRALEASVAQLAGQ 402
++E + A+L GELARQ E ++ L + + L Q
Sbjct: 1261 YRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQ 1320
Query: 403 LKELSGHLPALSSRLD--------LQEQMLGLRLSEAKTEWEGAERKSLEDLARWR---- 450
L+E AL+ L L+EQ +EAK E + K+ ++A+WR
Sbjct: 1321 LEEEGKAKNALAHALQSARHDCDLLREQY--EEETEAKAELQRVLSKANSEVAQWRTKYE 1378
Query: 451 -------KEVTEHLRGVREKVDGLPQQIESVSDKC--------LLHKSDSDLRISAE-GK 494
+E+ E + + +++ + +E+V+ KC L DL + E
Sbjct: 1379 TDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSN 1438
Query: 495 AREFKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQ 554
A + ++ +L+ + E++ ++ Q + + ++ KL+N + ++++
Sbjct: 1439 AAAAALDKKQRNFDKILAEWKQKYEESQS-ELESSQKEARSLSTELFKLKNAYE--ESLE 1495
Query: 555 NLR-FNTEARLRTQEMATLWESV 576
+L F E + +E++ L E +
Sbjct: 1496 HLETFKRENKNLQEEISDLTEQL 1518
Score = 43.5 bits (101), Expect = 6e-04
Identities = 76/339 (22%), Positives = 144/339 (42%), Gaps = 41/339 (12%)
Query: 52 SHPTSTASVPEQDTAKHWNQLEQWVVELQAEVAC---LREHKQRCERATRSLLRELLQVR 108
SH A+ ++ + L+ ++L V L+E+ ER L EL ++R
Sbjct: 1632 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELR 1691
Query: 109 ARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQV 168
A V+ Q ++ + A Q + + L +Q +L + ++ LT+L+
Sbjct: 1692 AVVE-------QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVE 1744
Query: 169 QQEAERRGAEQEAGLRLAKLTDLLQQ--EEQGREVACGALQKNQEDSSRRVDLEVARMQA 226
+ E R AE++A + + ++ +EQ ++KN E + + DL+ +A
Sbjct: 1745 EAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK--DLQHRLDEA 1802
Query: 227 QVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKL 286
E+++L+ K++ LQK LE R++ +LEG L E + E +
Sbjct: 1803 ------EQIALKGGKKQ------LQK----LEARVR-------ELEGELEAEQKRNAESV 1839
Query: 287 RGL--MEERLRALQGQHEE--SHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAW 342
+G+ E R++ L Q EE +LL +D ++ + +Q + + + K
Sbjct: 1840 KGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR 1899
Query: 343 DAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGE 381
+ L+E+ A Q N A+ A+Q+MH E
Sbjct: 1900 KVQHELDEAEERADIAESQVNKLRAKSRDIGAKQKMHDE 1938
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 68.9 bits (167), Expect = 1e-11
Identities = 141/577 (24%), Positives = 232/577 (40%), Gaps = 103/577 (17%)
Query: 42 LEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEV-ACLREHKQRCERATRSL 100
L EL++ E + + A+ E K EQ + +QA + A REH + ++ +
Sbjct: 290 LRELNK--EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI 347
Query: 101 --LRELLQ-----VRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRL 153
L+E L+ AR+Q + S LR +A +Q K+ E + L+ ++ + K L
Sbjct: 348 RTLQEQLENGPNTQLARLQQENSILRDALNQA--TSQVESKQNAELAKLRQELSKVSKEL 405
Query: 154 VEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDS 213
VE EA+ Q E +R+ E +A ++ L + E ALQK ++
Sbjct: 406 VEKSEAVR-------QDEQQRKALEAKAAAFEKQVLQLQASHRESEE----ALQKRLDEV 454
Query: 214 SRRV---DLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLK 270
SR + A ++A K E+ ++ A+L LQ S E R K E S L
Sbjct: 455 SRELCHTQSSHASLRADAEKAQEQQ-----QQMAELHSKLQSS--EAEVRSKCEELSGL- 506
Query: 271 LEGSLR------GELESRWEKLRGLME------------ERLRALQGQHEESHLLEQCQG 312
G L+ +L R + L+E + A Q Q L Q G
Sbjct: 507 -HGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSG 565
Query: 313 LDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGE 372
L+ +L + V+Q + N + KA +A E++ +L + Q E+ +
Sbjct: 566 LEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCL 625
Query: 373 LARQEMHGELVLLREKSRALEASVAQLAGQLKE----LSGHLPA-------LSSRLDLQE 421
+ Q M L LL E S + + + LKE L H PA L+S+L E
Sbjct: 626 IEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAE 685
Query: 422 QMLGLRLSEAK------TEWEGAER---KSLEDLAR-WRKEV-------------TEHLR 458
+ +E E EG R KS+E+ + WR +V +HL
Sbjct: 686 ETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLE 745
Query: 459 GVREKVDGLPQQIESVSDKCLLHKSDSDLRI-------SAEGKAREFKVGALRQELATLL 511
+ EK+ G ++ES SD+ H S + + SAE + +V LRQ L
Sbjct: 746 EIVEKLKG---ELES-SDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQ 801
Query: 512 SSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQ 548
S + K + + +LA + Q+ ++++ V+
Sbjct: 802 SQLDAAKSE-----AQKQSDELALVRQQLSEMKSHVE 833
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 68.9 bits (167), Expect = 1e-11
Identities = 141/577 (24%), Positives = 232/577 (40%), Gaps = 103/577 (17%)
Query: 42 LEELSERYESSHPTSTASVPEQDTAKHWNQLEQWVVELQAEV-ACLREHKQRCERATRSL 100
L EL++ E + + A+ E K EQ + +QA + A REH + ++ +
Sbjct: 290 LRELNK--EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKI 347
Query: 101 --LRELLQ-----VRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRL 153
L+E L+ AR+Q + S LR +A +Q K+ E + L+ ++ + K L
Sbjct: 348 RTLQEQLENGPNTQLARLQQENSILRDALNQA--TSQVESKQNAELAKLRQELSKVSKEL 405
Query: 154 VEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDS 213
VE EA+ Q E +R+ E +A ++ L + E ALQK ++
Sbjct: 406 VEKSEAVR-------QDEQQRKALEAKAAAFEKQVLQLQASHRESEE----ALQKRLDEV 454
Query: 214 SRRV---DLEVARMQAQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLK 270
SR + A ++A K E+ ++ A+L LQ S E R K E S L
Sbjct: 455 SRELCHTQSSHASLRADAEKAQEQQ-----QQMAELHSKLQSS--EAEVRSKCEELSGL- 506
Query: 271 LEGSLR------GELESRWEKLRGLME------------ERLRALQGQHEESHLLEQCQG 312
G L+ +L R + L+E + A Q Q L Q G
Sbjct: 507 -HGQLQEARAENSQLTERIRSIEALLEAGQARDAQDVQASQAEADQQQTRLKELESQVSG 565
Query: 313 LDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGE 372
L+ +L + V+Q + N + KA +A E++ +L + Q E+ +
Sbjct: 566 LEKEAIELREAVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCL 625
Query: 373 LARQEMHGELVLLREKSRALEASVAQLAGQLKE----LSGHLPA-------LSSRLDLQE 421
+ Q M L LL E S + + + LKE L H PA L+S+L E
Sbjct: 626 IEAQTMEALLALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAE 685
Query: 422 QMLGLRLSEAK------TEWEGAER---KSLEDLAR-WRKEV-------------TEHLR 458
+ +E E EG R KS+E+ + WR +V +HL
Sbjct: 686 ETQSTLQAECDQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLE 745
Query: 459 GVREKVDGLPQQIESVSDKCLLHKSDSDLRI-------SAEGKAREFKVGALRQELATLL 511
+ EK+ G ++ES SD+ H S + + SAE + +V LRQ L
Sbjct: 746 EIVEKLKG---ELES-SDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQ 801
Query: 512 SSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQ 548
S + K + + +LA + Q+ ++++ V+
Sbjct: 802 SQLDAAKSE-----AQKQSDELALVRQQLSEMKSHVE 833
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 68.9 bits (167), Expect = 1e-11
Identities = 137/535 (25%), Positives = 221/535 (41%), Gaps = 84/535 (15%)
Query: 72 LEQWVVELQAEVACLREHKQRCERATRSL---------LRELL-QVRARVQLQGSELRQL 121
LEQ + L+ L++HK++ R L L E+L +RA + Q L L
Sbjct: 1847 LEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLAL 1906
Query: 122 QQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREAL-TRLRRRQVQQEAERRGAE-- 178
QQ+ AQ E E Q QA+ K + EAL + + Q+EA R AE
Sbjct: 1907 QQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEAL 1966
Query: 179 QEA-----GLRLAKLTDLLQQEEQGREV------------ACGALQKNQEDSSRRVDLEV 221
QEA K LL+Q E R + AC A + E++ R + E+
Sbjct: 1967 QEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEI 2026
Query: 222 ----ARMQAQVTKLGEEVSLR--FLKREAKLCGFLQKSF-------LALEKRMKASESSR 268
R Q V +L + ++ R L+ + + L+KS + EK+ E
Sbjct: 2027 QDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREE 2086
Query: 269 LKLEG------SLRGELESRWEKLRGLME----ERLRALQGQHEESHLLEQCQGLDAAVA 318
++ G L+ L + +++ L E L AL H+ S + EQ LD+
Sbjct: 2087 EEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEP 2146
Query: 319 QLTKFVQQNQASLNRVLLAE----EKAWDAKGRLEESRAGELAAY-VQENLEAAQLAGEL 373
+L + +++ QA+L + E EKA D L +++A + V L+A+ L +
Sbjct: 2147 RLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDS 2206
Query: 374 ARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKT 433
+Q + EL L R RALE G L SR + Q+ + EA+
Sbjct: 2207 EQQRLQDELELTR---RALEKERLHSPGATSTAE-----LGSRGEQGVQLGEVSGVEAEP 2258
Query: 434 EWEGAERKSLEDLARWRKEVTEHLRG--VREKVDGLPQQIESVSDKCLLHKSDSDLRISA 491
+G E++S WR+ + EHL+ R ++D Q +V + L + + + R
Sbjct: 2259 SPDGMEKQS------WRQRL-EHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLK 2311
Query: 492 EGKAREFKVGALRQELATLLSSVQLLKEDNPGRK------IAEMQGKLATFQNQI 540
R + G+L AT S Q +D G+K +AE+Q ++ Q Q+
Sbjct: 2312 REAMRAAQAGSLEISKATASSPTQ---QDGRGQKNSDAKCVAELQKEVVLLQAQL 2363
Score = 68.2 bits (165), Expect = 2e-11
Identities = 133/553 (24%), Positives = 236/553 (42%), Gaps = 70/553 (12%)
Query: 33 GLASPEPLSLEEL---SERYESSHPTSTASVPEQ-DTAKHWNQLEQWVVELQAEVACLRE 88
GL + + SL EL E ESSH EQ + + EQ + EL + L+
Sbjct: 530 GLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT 589
Query: 89 HKQ--RCERATRSLLRELLQVRARVQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQM 146
R S L E L + +V L +L QL++E + E + LQ +
Sbjct: 590 EVADLRAAAVKLSALNEALALD-KVGLN-QQLLQLEEENQSVCSRMEAAEQARNALQVDL 647
Query: 147 QALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGAL 206
+KR + E T L + Q+AE GAE +A LR D+ +++E+ +
Sbjct: 648 AEAEKRREALWEKNTHLEAQL--QKAEEAGAELQADLR-----DIQEEKEE--------I 692
Query: 207 QKNQEDSSRRVDLEVARMQA--QVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKAS 264
QK +S + + +++ Q K EEV R ++ + L + ALE R++A
Sbjct: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALV----REKAALEVRLQAV 748
Query: 265 ESSRLKLEGSLRGELESRWEKLRGLMEERLRALQGQHEESHLLEQCQG-LDAAVAQLTKF 323
E R L L+G L S E L + E +++ ++E +G L+ + +T+
Sbjct: 749 ERDRQDLAEQLQG-LSSAKELLESSLFE-------AQQQNSVIEVTKGQLEVQIQTVTQ- 799
Query: 324 VQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELV 383
V+ E + + E S+A ++ +AA A +LA+ E G+
Sbjct: 800 -------AKEVIQGEVRCLKLELDTERSQA-------EQERDAA--ARQLAQAEQEGKTA 843
Query: 384 LLREKSRALEASVAQLAGQL-KELSGHLPALSSRLDLQEQ---MLGLRLSEAKTEWEGAE 439
L ++K+ A E V QL + KE S H L+ L+ E+ L +RL E +TE E +
Sbjct: 844 LEQQKA-AHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQ 902
Query: 440 RKSLEDLARWRKEVTE-HLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREF 498
+ E+ + + + L +E+V L +++ K +D E ++
Sbjct: 903 AQREEERTQAESALCQMQLETEKERVSLLETLLQT-------QKELADASQQLERLRQDM 955
Query: 499 KVGALRQELATLLSSVQLLKEDNPGRKIA-EMQGKLATFQNQIMK-LENCVQANKTIQNL 556
KV L+++ T + QL + ++ A + + LA Q + L++ + K +++L
Sbjct: 956 KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDL 1015
Query: 557 RFNTEARLRTQEM 569
+ A+ +Q +
Sbjct: 1016 KSQLVAQDDSQRL 1028
Score = 68.2 bits (165), Expect = 2e-11
Identities = 151/646 (23%), Positives = 251/646 (38%), Gaps = 128/646 (19%)
Query: 3 ELADSGPSGASA----PSQLRAVTLEDLGLLLAGGLASPEPLSLEELSERYESSHPT--- 55
EL+ G S S P Q A +L G LL A +L +L + + T
Sbjct: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261
Query: 56 ---STASVPEQ--DTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRAR 110
+ E+ DT +Q+ + +LQ +++ +E K + E SL EL+++
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHET 1321
Query: 111 VQLQGSELRQLQQEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVR------------- 157
+ S LR+ + + A E L Q++ L +VE R
Sbjct: 1322 MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDL 1381
Query: 158 ---EALTRLRRRQVQQEAERRGAEQEAG-----------LRLAKLTDLLQQEEQGREVAC 203
+ +L+ +V+ E ER A QE G LA LT L + E+ E
Sbjct: 1382 RTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR 1441
Query: 204 GALQ---KNQEDSSRRVDL----------EVARMQAQVTKLG------EEVSLRFLKREA 244
G +Q K +E ++L EV Q Q+ +L E + + +RE
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501
Query: 245 KLC-----------------GFLQKSFLALEKRMKASESSRLKLEG---------SLRGE 278
KL L+ L LEK+ + ES R +++ L E
Sbjct: 1502 KLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALE 1561
Query: 279 LESRWEKLRGLMEERLRALQGQHEESH---------LLEQCQGLDAAVAQLTKFVQQNQA 329
LE K+ ++ ++ L+GQ E L E+ Q L A +Q+ +
Sbjct: 1562 LEENHHKME-CQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQI-----HDLE 1615
Query: 330 SLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKS 389
S + VL E + D + + + + EL + L +L R++ EL+L +E+
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIEEL------QRQKEHLTQDLERRDQ--ELMLQKERI 1667
Query: 390 RALEASVAQ----LAGQLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLED 445
+ LE + L L+++ L L Q Q++ R E K A+R SLE
Sbjct: 1668 QVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP-SKAQRGSLEH 1726
Query: 446 ----LARWRKEV---TEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREF 498
L KEV EH+ ++E D L QQ++ + K ++ L +S RE
Sbjct: 1727 MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKV----GETSLLLS----QREQ 1778
Query: 499 KVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLE 544
++ L+Q+L + LKE + ++ E Q LA ++ L+
Sbjct: 1779 EIVVLQQQLQEAREQGE-LKEQSLQSQLDEAQRALAQRDQELEALQ 1823
Score = 67.8 bits (164), Expect = 3e-11
Identities = 127/543 (23%), Positives = 228/543 (41%), Gaps = 96/543 (17%)
Query: 73 EQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQEARP----- 127
E+ ELQA++ ++E K+ + ++L + R + + ++L QL QEA+
Sbjct: 672 EEAGAELQADLRDIQEEKEEIQ-------KKLSESRHQQEAATTQLEQLHQEAKRQEEVL 724
Query: 128 AAQAPEKEA--PEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAG--- 182
A EKEA E + L+ ++QA+++ ++ E L L + E+ A+Q+
Sbjct: 725 ARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIE 784
Query: 183 LRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKR 242
+ +L +Q Q +EV G E +++L+ R QA+ + L ++
Sbjct: 785 VTKGQLEVQIQTVTQAKEVIQG------EVRCLKLELDTERSQAEQERDAAARQLAQAEQ 838
Query: 243 EAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKL-RGLMEERLR------ 295
E K L++ A EK + K + EL E L R ME +R
Sbjct: 839 EGKTA--LEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT 896
Query: 296 ---ALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAW-DAKGRLEES 351
A+Q Q EE E+ Q ++A+ Q+ ++ + SL LL +K DA +LE
Sbjct: 897 EMEAIQAQREE----ERTQA-ESALCQMQLETEKERVSLLETLLQTQKELADASQQLERL 951
Query: 352 RAG---------ELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQ 402
R E +Q L+ AQ + A ++ +L L+E+S +L L Q
Sbjct: 952 RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQ 1011
Query: 403 LKELSGHLPAL--SSRL--------------------DLQEQMLGLRLSEAKTEWE---- 436
+++L L A S RL +L+ + L LS + E
Sbjct: 1012 VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVL 1071
Query: 437 -----------GAERKSLEDLARWRKEVTEHLRGVREKV-----DGLPQQIESVSDKCLL 480
A R+ +++ +KE++ + +R++V D L Q+ + + +
Sbjct: 1072 QEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEAS 1131
Query: 481 HKSDSDLRISAEGKAREFKVGALRQELATLLSSVQ-LLKEDNPGRKIAEMQGKLATFQNQ 539
H ++ LR S A+E K L+ L + S ++ L E PG + A+ Q +LA+ +
Sbjct: 1132 HITEQQLRASL--WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQ-AQAQAQLASLYSA 1188
Query: 540 IMK 542
+ +
Sbjct: 1189 LQQ 1191
Score = 55.5 bits (132), Expect = 2e-07
Identities = 114/534 (21%), Positives = 217/534 (40%), Gaps = 51/534 (9%)
Query: 63 QDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQ 122
QD K + + + V LR+ C+ A L ++ Q + L++L
Sbjct: 382 QDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT 441
Query: 123 QEARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVREALT-------RLRRRQVQQEAERR 175
E A E L + + L K E+R+ L RLRR V+ + +
Sbjct: 442 GERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGD 501
Query: 176 GAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRRVDLEVARMQAQVTKLGEEV 235
A+ + + +L +++ E+ +E+ G K E S + L A + +
Sbjct: 502 SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHL------- 554
Query: 236 SLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEKLRGLMEERLR 295
E +L Q A R + S + E +L+ E+ LR +L
Sbjct: 555 -------EGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVAD----LRA-AAVKLS 602
Query: 296 ALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGE 355
AL E+ L++ GL+ QL + ++NQ+ +R+ AE+ + L E+
Sbjct: 603 AL----NEALALDKV-GLN---QQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRR 654
Query: 356 LAAYVQE-NLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALS 414
A + + +LEA E A E+ +L ++E+ ++ +++ Q + + L L
Sbjct: 655 EALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLH 714
Query: 415 SRLDLQEQML--GLRLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGV---REKVDGLPQ 469
QE++L ++ EA + A L+ + R R+++ E L+G+ +E ++
Sbjct: 715 QEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLF 774
Query: 470 QIESVSDKCLLHKSDSDLRISAEGKAREF---KVGALRQELATLLSSVQLLKEDNPGRKI 526
+ + + + K +++I +A+E +V L+ EL T S + + D R++
Sbjct: 775 EAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAE-QERDAAARQL 833
Query: 527 --AEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLR 578
AE +GK A Q + + Q + ++ E QE+A ES+ R
Sbjct: 834 AQAEQEGKTALEQQKAAHEKEVNQLRE-----KWEKERSWHQQELAKALESLER 882
Score = 51.2 bits (121), Expect = 3e-06
Identities = 117/538 (21%), Positives = 221/538 (41%), Gaps = 68/538 (12%)
Query: 63 QDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQ 122
QD K LE +EL+ HK C++ L++EL R ++ + L
Sbjct: 1546 QDLKKQLVTLECLALELEEN-----HHKMECQQ---KLIKELEGQRETQRVALTHLTLDL 1597
Query: 123 QEARPAAQAPEKEAPEFSG----LQNQMQALDKRLVEVREALTRLRRRQ--VQQEAERRG 176
+E QA + + L ++Q D+ + RE + L+R++ + Q+ ERR
Sbjct: 1598 EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERR- 1656
Query: 177 AEQEAGLRLAKLTDLLQQ--------EEQGREVACGALQKNQEDSSRRVDLEVARMQAQV 228
+QE L+ ++ L Q EE ++ ++ +E +++R ++ + +
Sbjct: 1657 -DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKG 1715
Query: 229 TKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEK--L 286
+ SL +K + +K ++ + + + +LE L+G E L
Sbjct: 1716 PSKAQRGSLEHMKL---ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL 1772
Query: 287 RGLMEERLRALQGQHEESHLLEQC--QGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDA 344
E+ + LQ Q +E+ + Q L + + + + + Q L + +++ A
Sbjct: 1773 LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEAL---QQEQQQA 1829
Query: 345 KGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVA---QLAG 401
+G +E R E A +Q LE A + +E HGEL +E++R LE +A +
Sbjct: 1830 QG--QEERVKEKADALQGALEQAHMT----LKERHGELQDHKEQARRLEEELAVEGRRVQ 1883
Query: 402 QLKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARW------RKEVTE 455
L+E+ G L A S + L + +E E E E ++L+D W KE +
Sbjct: 1884 ALEEVLGDLRAESREQEKALLALQQQCAEQAQEHE-VETRALQD--SWLQAQAVLKERDQ 1940
Query: 456 HLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQ 515
L +R + Q E+ ++ ++ A GKA AL+ + LL +
Sbjct: 1941 ELEALRAESQSSRHQEEAA-------RARAEALQEALGKAH----AALQGKEQHLLEQAE 1989
Query: 516 LLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANK---TIQNLRFNTEARLRTQEMA 570
L + + A +Q L Q +LE ++ + Q+LR+ + + Q +A
Sbjct: 1990 LSR--SLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALA 2045
Score = 37.4 bits (85), Expect = 0.045
Identities = 130/584 (22%), Positives = 234/584 (40%), Gaps = 93/584 (15%)
Query: 73 EQWVVELQAEVAC-LREHKQRCERATRSLLRELLQV-----RARVQLQGSELR-QLQQEA 125
EQ E AEV LR H ++ + ++L ++ ++ RAR +L E + Q++QE
Sbjct: 106 EQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEF 165
Query: 126 RPAAQAPE--------KEAPEFSGLQNQMQ-ALDKRLVEVREALTRL---------RRRQ 167
E +E F +M+ A D+ L+E++ RL R
Sbjct: 166 FKGYLKGEHGRLLSLWREVVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTV 225
Query: 168 VQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVACGALQKNQE--DSSRRVDLEVARMQ 225
Q E G+ + G A+L LL + + E+ A +++QE + DLE A +Q
Sbjct: 226 GAQSREPNGSGRMDGREPAQLLLLLAKTQ---ELEKEAHERSQELIQLKSQGDLEKAELQ 282
Query: 226 AQVTKLGEEVSLRFLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWEK 285
+VT+L L + K +K AL + ++ E++ +L +E
Sbjct: 283 DRVTELSA-----LLTQSQKQNEDYEKMIKALRETVEILETNHTEL-------MEHEASL 330
Query: 286 LRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDAK 345
R EE+L Q + + ++ + +G + A +N L+ + ++ DA
Sbjct: 331 SRNAQEEKLSLQQVIKDITQVMVE-EGDNIAQGS----GHENSLELDSSIFSQFDYQDAD 385
Query: 346 GRLEE-----SRAGELAAYVQENLEAAQLAGELARQE---MHGELVLLREKSRALEASVA 397
L +R + +++ L Q A L +Q+ E LR++ + L
Sbjct: 386 KALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERD 445
Query: 398 QLAGQLKELSGHLPALS--------SRLDLQEQMLGL-----RLSEAKTEW-------EG 437
LAGQ +L G + +LS +R +L++Q+ L RL E +G
Sbjct: 446 TLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQG 505
Query: 438 AERKSLEDL---ARWRKEVTEHLRGVREKVDGLPQQIESVSDKCLLHKSDSDLRISAEGK 494
+ + E+L R R+ + E L G+ K Q ES+S+ L ++ + E
Sbjct: 506 QKEEQQEELHLAVRERERLQEMLMGLEAK------QSESLSELITLREALESSHLEGELL 559
Query: 495 ARE-----FKVGALRQELATLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQA 549
+E + Q +A L SS LK + + A + KL+ N+ + L+ V
Sbjct: 560 RQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAV--KLSAL-NEALALDK-VGL 615
Query: 550 NKTIQNLRFNTEARLRTQEMATLWESVLRLWSEEGPRTPLGSWK 593
N+ + L ++ E A + L++ E + W+
Sbjct: 616 NQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWE 659
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 68.9 bits (167), Expect = 1e-11
Identities = 127/540 (23%), Positives = 229/540 (42%), Gaps = 61/540 (11%)
Query: 63 QDTAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQ 122
Q+ H + E+ + EL+ E +E K+ E+ RSL R+L + ++ + L+
Sbjct: 474 QELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLE 533
Query: 123 QEARPAAQAPEKEAPEFSGLQNQMQALDKRLV---EVREALTRLRRRQVQQEAERRGAEQ 179
++ + Q + + + L+ L E EAL + QEA + E+
Sbjct: 534 EQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV--NSSLQEAWGKPEEE 591
Query: 180 EAGLRLAKLTDLLQQE---EQGREVACGALQKNQEDSSRRVDLEVARMQA--------QV 228
+ GL+ A+L D QE E+ A L+K ++ R L ++QA Q
Sbjct: 592 QRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQ 651
Query: 229 TKLGEEVSLRFLKRE----AKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESRWE 284
+ + SL L+ E L ++ S LA+ K +A ++ + E L+ + E +
Sbjct: 652 RESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSK-EGECQ 710
Query: 285 KLRGLMEERLRALQGQHEESHLLE-QCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWD 343
+LR +E+ + + +H E LE QCQ Q T+ ++ +L EK
Sbjct: 711 QLREEVEQCQQLAEARHRELRALESQCQ-------QQTQLIE---------VLTAEKGQQ 754
Query: 344 AKGRLEESRAGELAAYV---QENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLA 400
G ++ A ELAA + Q LE Q GE+ Q + ++V L+ K RA ++
Sbjct: 755 GVGPPTDNEARELAAQLALSQAQLEVHQ--GEV--QRLQAQVVDLQAKMRAALDDQDKVQ 810
Query: 401 GQLKELSGHLPALSSRL-DLQEQMLGLRLSEAK-----TEWEGAERKSLEDLARWRKEVT 454
QL L + + L+EQ L + + +E EGA ++ D A+ R+
Sbjct: 811 SQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQRE--- 867
Query: 455 EHLRGVRE-----KVDGLPQQIESVSDKCLLHKSDSD-LRISAEGKAREFKVGALRQELA 508
E LR ++E K Q+E + LH++++D + + A + + + LA
Sbjct: 868 EELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALTVEKERVEEALA 927
Query: 509 TLLSSVQLLKEDNPGRKIAEMQGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQE 568
+ +Q KE R+ ++ ++A Q + L+ ++A K +A+L E
Sbjct: 928 CAVQELQDAKE-AASREREGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAE 986
Score = 62.0 bits (149), Expect = 2e-09
Identities = 111/483 (22%), Positives = 205/483 (42%), Gaps = 50/483 (10%)
Query: 74 QWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQG---SELRQLQQEARPAAQ 130
Q + EL ++ L + + E R +L Q+ +QL+ + L +L +E P +
Sbjct: 398 QEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQE 457
Query: 131 APEKEAPEFSGLQNQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTD 190
+ E L ++Q L E L LRR + QQ+ E+ EQE +L
Sbjct: 458 ELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQF 517
Query: 191 LLQQEEQ-GREVACGALQKNQEDSSR-RVDLEVARMQAQVTKLGEEVSLRFLKREA--KL 246
L Q Q + V+ QK Q + + +V ++ G E+ + K EA +
Sbjct: 518 LETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
Query: 247 CGFLQKSFLALEKRMKASESSRLK----LEGS-------LRGELESRWEKLRG---LMEE 292
LQ+++ E+ + + ++L EGS ELE + + G L+E
Sbjct: 578 NSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQLLEG 637
Query: 293 RLRALQG-----QHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEE--KAWDA- 344
+L+ALQ Q ES + L+A A + Q +ASL V A+E KA A
Sbjct: 638 KLQALQADYQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAE 697
Query: 345 KGRLEESRAGELAAYVQENLEAAQLAGELARQEMHGELVLLREKSRALEASVAQLAGQ-- 402
K + +S+ GE ++E +E Q E +E+ +++++ +E A+ Q
Sbjct: 698 KEAILQSKEGE-CQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGV 756
Query: 403 -------LKELSGHLPALSSRLDLQEQMLGLRLSEAKTEWEGAERKSLEDLARWRKEVT- 454
+EL+ L ++L++ + + RL + + R +L+D + + +++
Sbjct: 757 GPPTDNEARELAAQLALSQAQLEVHQGEV-QRLQAQVVDLQAKMRAALDDQDKVQSQLSM 815
Query: 455 --EHLRGVREKVDGLPQQIESVSD-------KCLLHKSDSDLRISAEGKAREFKVGALRQ 505
LR + V L +Q E+++ +C + + E + RE ++ AL++
Sbjct: 816 AEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQEERADEAQQREEELRALQE 875
Query: 506 ELA 508
EL+
Sbjct: 876 ELS 878
Score = 52.0 bits (123), Expect = 2e-06
Identities = 113/533 (21%), Positives = 212/533 (39%), Gaps = 94/533 (17%)
Query: 91 QRCERATRSLLRELLQVRARVQLQGSELRQL-------QQEARPAAQAPEKEAPEFSGLQ 143
+R E + L +EL R + + L QQ+A A+ ++ P S
Sbjct: 338 RRLESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAA 397
Query: 144 NQMQALDKRLVEVREALTRLRRRQVQQEAERRGAEQEAGLRLAKLTDLLQQEEQGREVAC 203
+MQ L ++L + T++ QQ A+ L +L LQ +E R
Sbjct: 398 QEMQELGEKLQALERERTKVEEVNRQQSAQ-----------LEQLVKELQLKEDARA--- 443
Query: 204 GALQKNQEDSSRRVDLEVARMQAQVTKLGEEVSLRFLKREAKLC--GFLQKSFLALEKRM 261
S R+ E+A +Q +++ G+E + + + L ++ L +
Sbjct: 444 ---------SLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREK 494
Query: 262 KASESSRLKLEGSLRG----------ELESRWEKLRGLMEERLRALQGQHEESHLLEQCQ 311
K + + LE +R +L + + L E++ + +Q ++ HL +Q
Sbjct: 495 KQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQ---DKDHLSQQVG 551
Query: 312 GLDAAVA----QLTKFVQQNQASLNRVLLAEEKAWDAKGRLEESRAGELAAYVQENLEAA 367
L+ +L ++N+A L V + ++AW G+ EE + G L+ A
Sbjct: 552 MLERLAGPPGPELPVAGEKNEA-LVPVNSSLQEAW---GKPEEEQRG---------LQEA 598
Query: 368 QLAGELARQEMHGELVLLREKSRALEASVAQLAGQLKELSGHLPALSSRLD-LQEQMLGL 426
QL ++ E LR+ +R LE + + G+ + L G L AL + LQ++ +
Sbjct: 599 QLDDTKVQEGSQEE--ELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAI 656
Query: 427 RLSEAKTEWEGAERKSLEDLARWRKEVTEHLRGVREKVDGLPQQ-------IESVSDKC- 478
+ S A E E A + L D ++ L VR+ + + Q ++S +C
Sbjct: 657 QGSLASLEAEQASIRHLGD------QMEASLLAVRKAKEAMKAQMAEKEAILQSKEGECQ 710
Query: 479 LLHKSDSDLRISAEGKAREFKVGALRQELATLLSSVQLLKE---------DNPGRKIAEM 529
L + + AE + RE + + + T L V ++ DN R++A
Sbjct: 711 QLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQ 770
Query: 530 ----QGKLATFQNQIMKLENCVQANKTIQNLRFNTEARLRTQEMATLWESVLR 578
Q +L Q ++ +L+ Q +R + + + Q ++ E+VLR
Sbjct: 771 LALSQAQLEVHQGEVQRLQ--AQVVDLQAKMRAALDDQDKVQSQLSMAEAVLR 821
Score = 49.3 bits (116), Expect = 1e-05
Identities = 97/451 (21%), Positives = 182/451 (40%), Gaps = 57/451 (12%)
Query: 5 ADSGPSGASAPSQLRAVTLEDLGLLLAGGLASPEPLSLEELSERYESSHPTSTASVPEQD 64
A+ G G P+ A L L L+ ++ L + A++ +QD
Sbjct: 749 AEKGQQGVGPPTDNEARELA-AQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQD 807
Query: 65 TAKHWNQLEQWVVELQAEVACLREHKQRCERATRSLLRELLQVRARVQLQGSELRQLQQE 124
+ +QL L+ +++ K++ E R+ ++ELLQ R +G+ LQ+E
Sbjct: 808 KVQ--SQLSMAEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSER---EGA----LQEE 858
Query: 125 ARPAAQAPEKEAPEFSGLQNQMQALDKRLVEVR--EALTRLRRRQVQQEAERRGAEQ-EA 181
AQ E+E ++AL + L + + +L ++Q++ R + E
Sbjct: 859 RADEAQQREEE----------LRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAEL 908
Query: 182 GLRLAKLTDLLQQEEQGREVACGALQKNQEDSSRR---VDLEVARMQAQVTKLGEEVSLR 238
G+++ LT ++ E+ A LQ +E +SR ++ +VA +Q + L E+ L+
Sbjct: 909 GIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLERQVAGLQQEKESLQEK--LK 966
Query: 239 FLKREAKLCGFLQKSFLALEKRMKASESSRLKLEGSLRGELESR--------------WE 284
K A LQ E+R ++ + + + +L+ +L + +
Sbjct: 967 AAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECK 1026
Query: 285 KLRGLMEERLRALQGQHEESHLLEQCQGLDAAVAQLTKFVQQNQASLNRVLLAEEKAWDA 344
LRG +EE+ R LQ E +E+ + A + + + A +L ++K A
Sbjct: 1027 SLRGQLEEQGRQLQAAEE---AVEKLKATQADMGEKLSCTSNHLAECQAAMLRKDKEGAA 1083
Query: 345 KGRLEESRAGEL---AAYVQENLEAAQLAGELARQEMHGELVL-----LREKSRALEASV 396
E EL +QE +L E+ +E + + +L L + LE +
Sbjct: 1084 LREDLERTQKELEKATTKIQEYYN--KLCQEVTNRERNDQKMLADLDDLNRTKKYLEERL 1141
Query: 397 AQLAGQLKELSGHLPAL--SSRLDLQEQMLG 425
+L L AL +L +E+ LG
Sbjct: 1142 IELLRDKDALWQKSDALEFQQKLSAEERWLG 1172
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.128 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,219,867
Number of Sequences: 37866
Number of extensions: 1001476
Number of successful extensions: 6610
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 688
Number of HSP's that attempted gapping in prelim test: 4198
Number of HSP's gapped (non-prelim): 2047
length of query: 667
length of database: 18,247,518
effective HSP length: 109
effective length of query: 558
effective length of database: 14,120,124
effective search space: 7879029192
effective search space used: 7879029192
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.