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Search of human proteins with 22035606
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22035606 mitogen-activated protein kinase kinase kinase
kinase 4 isoform 3 [Homo sapiens]
(1212 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 2429 0.0
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 2262 0.0
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 2204 0.0
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 1594 0.0
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 1593 0.0
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 1578 0.0
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 1577 0.0
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 1566 0.0
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 1566 0.0
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 1560 0.0
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 1559 0.0
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens] 1476 0.0
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens] 1472 0.0
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens] 1470 0.0
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens] 1467 0.0
gi|118600963 Nik related kinase [Homo sapiens] 405 e-112
gi|145275208 myosin IIIA [Homo sapiens] 306 1e-82
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 296 8e-80
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 296 8e-80
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 269 1e-71
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 267 4e-71
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 259 8e-69
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 256 7e-68
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 256 7e-68
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 252 1e-66
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 248 2e-65
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 243 1e-63
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 243 1e-63
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 241 2e-63
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 239 2e-62
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 2429 bits (6296), Expect = 0.0
Identities = 1212/1212 (100%), Positives = 1212/1212 (100%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVED 540
VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVED
Sbjct: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVED 540
Query: 541 RFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRS 600
RFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRS
Sbjct: 541 RFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRS 600
Query: 601 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP 660
PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
Sbjct: 601 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP 660
Query: 661 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 720
GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK
Sbjct: 661 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 720
Query: 721 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG 780
ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
Sbjct: 721 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG 780
Query: 781 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI 840
ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI
Sbjct: 781 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI 840
Query: 841 SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS 900
SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS
Sbjct: 841 SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS 900
Query: 901 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD 960
EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD
Sbjct: 901 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD 960
Query: 961 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV 1020
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV
Sbjct: 961 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV 1020
Query: 1021 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI 1080
YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI
Sbjct: 1021 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI 1080
Query: 1081 YLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY 1140
YLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY
Sbjct: 1081 YLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAY 1140
Query: 1141 IRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1200
IRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY
Sbjct: 1141 IRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVY 1200
Query: 1201 FMTLGRTSLLSW 1212
FMTLGRTSLLSW
Sbjct: 1201 FMTLGRTSLLSW 1212
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 2262 bits (5861), Expect = 0.0
Identities = 1149/1220 (94%), Positives = 1150/1220 (94%), Gaps = 62/1220 (5%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVED 540
VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREV
Sbjct: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREV-- 538
Query: 541 RFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRS 600
PV + S S P L R P
Sbjct: 539 -----------------------PVRTTSRS----------PVLSRRDSP---------- 555
Query: 601 PVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP 660
LQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP
Sbjct: 556 ---------LQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP 606
Query: 661 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 720
GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK
Sbjct: 607 GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAK 666
Query: 721 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG 780
ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG
Sbjct: 667 ELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNG 726
Query: 781 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI 840
ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI
Sbjct: 727 ETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQI 786
Query: 841 SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS 900
SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS
Sbjct: 787 SPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNS 846
Query: 901 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD 960
EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD
Sbjct: 847 EILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKD 906
Query: 961 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV 1020
KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV
Sbjct: 907 KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEV 966
Query: 1021 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI 1080
YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI
Sbjct: 967 YAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDI 1026
Query: 1081 YLPTH--------IQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG 1132
YLPTH IQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG
Sbjct: 1027 YLPTHVRKNPHSMIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG 1086
Query: 1133 EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1192
EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
Sbjct: 1087 EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1146
Query: 1193 SGGSSQVYFMTLGRTSLLSW 1212
SGGSSQVYFMTLGRTSLLSW
Sbjct: 1147 SGGSSQVYFMTLGRTSLLSW 1166
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 2204 bits (5711), Expect = 0.0
Identities = 1147/1320 (86%), Positives = 1162/1320 (88%), Gaps = 108/1320 (8%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT
Sbjct: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR
Sbjct: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE
Sbjct: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
Query: 481 VLQQQLLQ----------------------------EQAMLL---HDHRR---------P 500
VLQQQLLQ EQA LL HDHRR P
Sbjct: 481 VLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPP 540
Query: 501 HPQHSQQPP----PPQQERSKPSFHAPE------------PKAHYEPADRARE--VEDRF 542
PQ + P P + +P+ A E P+A + R E V R
Sbjct: 541 PPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRS 600
Query: 543 RKTNHSSPEAQSKQTGRVLEPPVP--------------SRSESFSNGNSESVHPALQRP- 587
++ + E+ R EP V SRS SFS+ + + H L+
Sbjct: 601 ESFSNGNSESVHPALQRPAEPQVQWSHLASLKNNVSPVSRSHSFSDPSPKFAHHHLRSQD 660
Query: 588 -----------------------------------AEPQVPVRTTSRSPVLSRRDSPLQG 612
P+VPVRTTSRSPVLSRRDSPLQG
Sbjct: 661 PCPPSRSEVLSQSSDSKSEAPDPTQKAWSRSDSDEVPPRVPVRTTSRSPVLSRRDSPLQG 720
Query: 613 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGE 672
SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGE
Sbjct: 721 SGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGE 780
Query: 673 RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH 732
RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH
Sbjct: 781 RFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPH 840
Query: 733 KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHD 792
KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHD
Sbjct: 841 KVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHD 900
Query: 793 DVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVV 852
DVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVV
Sbjct: 901 DVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVV 960
Query: 853 GFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNL 912
GFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNL
Sbjct: 961 GFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNL 1020
Query: 913 LVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRN 972
LVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRN
Sbjct: 1021 LVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRN 1080
Query: 973 KILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM 1032
KILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM
Sbjct: 1081 KILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFM 1140
Query: 1033 AFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKP 1092
AFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKP
Sbjct: 1141 AFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKP 1200
Query: 1093 HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK 1152
HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK
Sbjct: 1201 HAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEK 1260
Query: 1153 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1212
AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
Sbjct: 1261 AIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1320
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 1594 bits (4128), Expect = 0.0
Identities = 866/1329 (65%), Positives = 973/1329 (73%), Gaps = 149/1329 (11%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EEE+RR E EQEYIRRQLEEEQR LE
Sbjct: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYIRRQLEEEQRQLE 459
Query: 481 VLQQQLLQEQAMLLHDHRRP----------------------HPQHSQQPPPPQQERSKP 518
+LQQQLL EQA+LL R+ QH +Q P ++ KP
Sbjct: 460 ILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK--KP 517
Query: 519 SFHAPE------------------------------PKAHYEPADRAREVEDRFRKTNH- 547
+H E H +P ++ T+H
Sbjct: 518 LYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHR 577
Query: 548 -SSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRR 606
P S T PP+P+R E F S + P+VP RTTS SP L+R+
Sbjct: 578 VEMPRQNSDPTSE--NPPLPTRIEKF----DRSSWLRQEEDIPPKVPQRTTSISPALARK 631
Query: 607 DSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GS 662
+SP GS Q S+ + R +E + R SGSSS SS SQP GS
Sbjct: 632 NSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGS 691
Query: 663 HPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKEL 722
PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA DLTALAKEL
Sbjct: 692 QPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA---DLTALAKEL 748
Query: 723 RAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSN 779
R + E RP KVTDYSSSSEES +++EE++D E E D + + + R + +
Sbjct: 749 RELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGS 808
Query: 780 GETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASSTLQKH----- 823
E +V + H S + + S+EGTL++R+T S S+ H
Sbjct: 809 NEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPD 868
Query: 824 ------------------------------------KSSSSFTPFIDPRLLQISPS---- 843
+ +SFTPF+DPR+ Q SP+
Sbjct: 869 LVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDE 928
Query: 844 SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEIL 903
++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRFNSEIL
Sbjct: 929 EDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEIL 988
Query: 904 CAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLR 963
CAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLR
Sbjct: 989 CAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLR 1048
Query: 964 VYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAW 1023
VYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAW
Sbjct: 1049 VYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAW 1108
Query: 1024 APKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLP 1083
APKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P
Sbjct: 1109 APKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIP 1168
Query: 1084 THIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRS 1143
+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI S
Sbjct: 1169 SHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHS 1228
Query: 1144 NQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMT 1203
NQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMT
Sbjct: 1229 NQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMT 1288
Query: 1204 LGRTSLLSW 1212
L R S+++W
Sbjct: 1289 LNRNSMMNW 1297
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 1593 bits (4126), Expect = 0.0
Identities = 866/1334 (64%), Positives = 974/1334 (73%), Gaps = 151/1334 (11%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EEE+RR E EQEYIRRQLEEEQR LE
Sbjct: 417 KQQEREQRRHYEEQMRR-----------------EEERRRAEHEQEYIRRQLEEEQRQLE 459
Query: 481 VLQQQLLQEQAMLLHDHRRP----------------------HPQHSQQPPPPQQERSKP 518
+LQQQLL EQA+LL R+ QH +Q P ++ KP
Sbjct: 460 ILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEK--KP 517
Query: 519 SFHAPE------------------------------PKAHYEPADRAREVEDRFRKTNH- 547
+H E H +P ++ T+H
Sbjct: 518 LYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHR 577
Query: 548 -SSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRR 606
P S T PP+P+R E F S + P+VP RTTS SP L+R+
Sbjct: 578 VEMPRQNSDPTSE--NPPLPTRIEKF----DRSSWLRQEEDIPPKVPQRTTSISPALARK 631
Query: 607 DSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GS 662
+SP GS Q S+ + R +E + R SGSSS SS SQP GS
Sbjct: 632 NSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGS 691
Query: 663 HPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG-----EVDLTA 717
PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA + DLTA
Sbjct: 692 QPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTA 751
Query: 718 LAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASS 774
LAKELR + E RP KVTDYSSSSEES +++EE++D E E D + + + R +
Sbjct: 752 LAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPT 811
Query: 775 LNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSASSTLQKH 823
+ E +V + H S + + S+EGTL++R+T S S+ H
Sbjct: 812 GAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGH 871
Query: 824 -----------------------------------------KSSSSFTPFIDPRLLQISP 842
+ +SFTPF+DPR+ Q SP
Sbjct: 872 INLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSP 931
Query: 843 S----SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRF 898
+ ++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIRKYKKRF
Sbjct: 932 TDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRF 991
Query: 899 NSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGK 958
NSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGK
Sbjct: 992 NSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGK 1051
Query: 959 KDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSV 1018
K+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++V
Sbjct: 1052 KNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAV 1111
Query: 1019 EVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVY 1078
E+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ Y
Sbjct: 1112 EIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSY 1171
Query: 1079 DIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSV 1138
DIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSV
Sbjct: 1172 DIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSV 1231
Query: 1139 AYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQ 1198
AYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQ
Sbjct: 1232 AYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQ 1291
Query: 1199 VYFMTLGRTSLLSW 1212
V+FMTL R S+++W
Sbjct: 1292 VFFMTLNRNSMMNW 1305
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 1578 bits (4085), Expect = 0.0
Identities = 847/1285 (65%), Positives = 965/1285 (75%), Gaps = 90/1285 (7%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EE R E+E +R+ EE+R+ ER ++RQL++E+ +L
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
Query: 481 VLQQQLLQEQAM----LLHDHRRPHPQH----SQQPPPPQQERSKPSFHAPEPKAHYEPA 532
LQ Q +++ + L H P +++ P +S+ H +P
Sbjct: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPT 532
Query: 533 DRAREVEDRFRKTNH--SSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEP 590
++ T+H P S T PP+P+R E F S + P
Sbjct: 533 KGLSGFQEALNVTSHRVEMPRQNSDPTSE--NPPLPTRIEKFDR----SSWLRQEEDIPP 586
Query: 591 QVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSS 650
+VP RTTS SP L+R++SP GS Q S+ + R +E + R SGSS
Sbjct: 587 KVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSS 646
Query: 651 SGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRP 706
S SS SQP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP
Sbjct: 647 SSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRP 706
Query: 707 LKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADEST 763
+PA DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E D +
Sbjct: 707 SRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTV 763
Query: 764 SGPEDTRAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQTQSASS-- 818
+ + R + + E +V + H S + + S+EGTL++R+T
Sbjct: 764 AVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRS 823
Query: 819 -----------------TLQKHK------------------------------SSSSFTP 831
Q H + +SFTP
Sbjct: 824 GHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTP 883
Query: 832 FIDPRLLQISPSS----GTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSD 887
F+DPR+ Q SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SD
Sbjct: 884 FVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSD 943
Query: 888 TPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLE 947
TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLE
Sbjct: 944 TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLE 1003
Query: 948 GLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERI 1007
GLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERI
Sbjct: 1004 GLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERI 1063
Query: 1008 KFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGF 1067
KFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GF
Sbjct: 1064 KFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGF 1123
Query: 1068 HAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDV 1127
H +DVDSG+ YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDV
Sbjct: 1124 HVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDV 1183
Query: 1128 VLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1187
VLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF
Sbjct: 1184 VLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1243
Query: 1188 FASVRSGGSSQVYFMTLGRTSLLSW 1212
FASVRSGGSSQV+FMTL R S+++W
Sbjct: 1244 FASVRSGGSSQVFFMTLNRNSMMNW 1268
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 1577 bits (4083), Expect = 0.0
Identities = 849/1290 (65%), Positives = 967/1290 (74%), Gaps = 92/1290 (7%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EE R E+E +R+ EE+R+ ER ++RQL++E+ +L
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
Query: 481 VLQQQLLQ----EQAMLLHDHRRPHPQH----SQQPPPPQQERSKPSFHAPEPKAHYEPA 532
LQ Q + E+ L H P +++ P +S+ H +P
Sbjct: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEIPHLVAVKSQGPALTASQSVHEQPT 532
Query: 533 DRAREVEDRFRKTNH--SSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEP 590
++ T+H P S T PP+P+R E F S + P
Sbjct: 533 KGLSGFQEALNVTSHRVEMPRQNSDPTSE--NPPLPTRIEKF----DRSSWLRQEEDIPP 586
Query: 591 QVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSS 650
+VP RTTS SP L+R++SP GS Q S+ + R +E + R SGSS
Sbjct: 587 KVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSS 646
Query: 651 SGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRP 706
S SS SQP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP
Sbjct: 647 SSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRP 706
Query: 707 LKPAG-----EVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEG 758
+PA + DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E
Sbjct: 707 SRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESET 766
Query: 759 ADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT-- 813
D + + + R + + E +V + H S + + S+EGTL++R+T
Sbjct: 767 HDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSG 826
Query: 814 ------QSASSTLQKH-----------------------------------------KSS 826
S S+ H +
Sbjct: 827 EKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTK 886
Query: 827 SSFTPFIDPRLLQISPS----SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNT 882
+SFTPF+DPR+ Q SP+ ++ F+ + +R E + + RK SVVNVNPTN
Sbjct: 887 ASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNI 946
Query: 883 RPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQ 942
RP SDTPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQ
Sbjct: 947 RPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQ 1006
Query: 943 MDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVV 1002
MDVLEGLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVV
Sbjct: 1007 MDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVV 1066
Query: 1003 KYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYG 1062
KYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+G
Sbjct: 1067 KYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFG 1126
Query: 1063 SCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGR 1122
S GFH +DVDSG+ YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGR
Sbjct: 1127 SHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGR 1186
Query: 1123 ITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCER 1182
ITKDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCER
Sbjct: 1187 ITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCER 1246
Query: 1183 NDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1212
NDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1247 NDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1276
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 1566 bits (4056), Expect = 0.0
Identities = 854/1340 (63%), Positives = 974/1340 (72%), Gaps = 145/1340 (10%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EE R E+E +R+ EE+R+ ER ++RQL++E+ +L
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
Query: 481 VLQQQLLQEQ----------------------AMLLHDHRRPHPQHSQQPP--------- 509
LQ Q +++ A + + R + Q S P
Sbjct: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISD 532
Query: 510 ---PPQQE----------RSKPSFHAPEPK-------------------AHYEPADRARE 537
PP+ E R+ P +P+ H +P
Sbjct: 533 PNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSG 592
Query: 538 VEDRFRKTNH--SSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVR 595
++ T+H P S T PP+P+R E F S + P+VP R
Sbjct: 593 FQEALNVTSHRVEMPRQNSDPTSE--NPPLPTRIEKFDR----SSWLRQEEDIPPKVPQR 646
Query: 596 TTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSN 655
TTS SP L+R++SP GS Q S+ + R +E + R SGSSS SS
Sbjct: 647 TTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSST 706
Query: 656 SGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG 711
SQP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA
Sbjct: 707 PSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPA- 765
Query: 712 EVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPED 768
DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E D + + +
Sbjct: 766 --DLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDI 823
Query: 769 TRAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT--------QSAS 817
R + + E +V + H S + + S+EGTL++R+T S S
Sbjct: 824 PRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDS 883
Query: 818 STLQKH-----------------------------------------KSSSSFTPFIDPR 836
+ H + +SFTPF+DPR
Sbjct: 884 NGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPR 943
Query: 837 LLQISPS----SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIR 892
+ Q SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SDTPEIR
Sbjct: 944 VYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIR 1003
Query: 893 KYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVL 952
KYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLEGLNVL
Sbjct: 1004 KYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVL 1063
Query: 953 VTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVI 1012
VTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERIKFLVI
Sbjct: 1064 VTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVI 1123
Query: 1013 ALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDV 1072
ALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GFH +DV
Sbjct: 1124 ALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDV 1183
Query: 1073 DSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWG 1132
DSG+ YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDVVLQWG
Sbjct: 1184 DSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWG 1243
Query: 1133 EMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1192
EMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR
Sbjct: 1244 EMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVR 1303
Query: 1193 SGGSSQVYFMTLGRTSLLSW 1212
SGGSSQV+FMTL R S+++W
Sbjct: 1304 SGGSSQVFFMTLNRNSMMNW 1323
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 1566 bits (4054), Expect = 0.0
Identities = 854/1345 (63%), Positives = 975/1345 (72%), Gaps = 147/1345 (10%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+QQEREQRR +E+ RR EE R E+E +R+ EE+R+ ER ++RQL++E+ +L
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYKRKQLEEQRQAER----LQRQLKQERDYLV 472
Query: 481 VLQQQLLQEQ----------------------AMLLHDHRRPHPQHSQQPP--------- 509
LQ Q +++ A + + R + Q S P
Sbjct: 473 SLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISD 532
Query: 510 ---PPQQE----------RSKPSFHAPEPK-------------------AHYEPADRARE 537
PP+ E R+ P +P+ H +P
Sbjct: 533 PNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSG 592
Query: 538 VEDRFRKTNH--SSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVR 595
++ T+H P S T PP+P+R E F S + P+VP R
Sbjct: 593 FQEALNVTSHRVEMPRQNSDPTSE--NPPLPTRIEKFDR----SSWLRQEEDIPPKVPQR 646
Query: 596 TTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSN 655
TTS SP L+R++SP GS Q S+ + R +E + R SGSSS SS
Sbjct: 647 TTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSST 706
Query: 656 SGSQP----GSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAG 711
SQP GS PGSQ+GS ER RVR++SKSEGSP E A KPE+ +++ RP +PA
Sbjct: 707 PSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPAS 766
Query: 712 -----EVDLTALAKELRAV---EDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADEST 763
+ DLTALAKELR + E RP KVTDYSSSSEES +++EE++D E E D +
Sbjct: 767 YKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTV 826
Query: 764 SGPEDTRAASSLNLSNGETESVKTMIVHDDVESEP---AMTPSKEGTLIVRQT------- 813
+ + R + + E +V + H S + + S+EGTL++R+T
Sbjct: 827 AVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRS 886
Query: 814 -QSASSTLQKH-----------------------------------------KSSSSFTP 831
S S+ H + +SFTP
Sbjct: 887 GHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTP 946
Query: 832 FIDPRLLQISPS----SGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSD 887
F+DPR+ Q SP+ ++ F+ + +R E + + RK SVVNVNPTN RP SD
Sbjct: 947 FVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSD 1006
Query: 888 TPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLE 947
TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LINRRRFQQMDVLE
Sbjct: 1007 TPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLE 1066
Query: 948 GLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERI 1007
GLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW TVGDLEGC+HYKVVKYERI
Sbjct: 1067 GLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERI 1126
Query: 1008 KFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGF 1067
KFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLVDLTVEEGQRLKVI+GS GF
Sbjct: 1127 KFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGF 1186
Query: 1068 HAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDV 1127
H +DVDSG+ YDIY+P+HIQ +I PHAI+ILP TDGME+LVCYEDEGVYVNTYGRITKDV
Sbjct: 1187 HVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDV 1246
Query: 1128 VLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1187
VLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF
Sbjct: 1247 VLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVF 1306
Query: 1188 FASVRSGGSSQVYFMTLGRTSLLSW 1212
FASVRSGGSSQV+FMTL R S+++W
Sbjct: 1307 FASVRSGGSSQVFFMTLNRNSMMNW 1331
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 1560 bits (4039), Expect = 0.0
Identities = 857/1365 (62%), Positives = 978/1365 (71%), Gaps = 166/1365 (12%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEE-RRRAEEEKRRVE----------------- 462
+QQEREQRR +E+ RR EE R E+E RR+ EEE+R++E
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYK 476
Query: 463 -------REQEYIRRQLEEEQRHLEVLQQQLLQEQ----------------------AML 493
R+ E ++RQL++E+ +L LQ Q +++ A
Sbjct: 477 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKE 536
Query: 494 LHDHRRPHPQHSQQPP------------PPQQE----------RSKPSFHAPEPK----- 526
+ + R + Q S P PP+ E R+ P +P+
Sbjct: 537 VEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLV 596
Query: 527 --------------AHYEPADRAREVEDRFRKTNH--SSPEAQSKQTGRVLEPPVPSRSE 570
H +P ++ T+H P S T PP+P+R E
Sbjct: 597 AVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSE--NPPLPTRIE 654
Query: 571 SFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIE 630
F S + P+VP RTTS SP L+R++SP GS Q S+ +
Sbjct: 655 KFDR----SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPD 710
Query: 631 PRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSP 686
R +E + R SGSSS SS SQP GS PGSQ+GS ER RVR++SKSEGSP
Sbjct: 711 LRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSP 770
Query: 687 SQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAV---EDVRPPHKVTDYSSSSEE 743
E A KPE+ +++ RP +PA DLTALAKELR + E RP KVTDYSSSSEE
Sbjct: 771 VLPHEPAKVKPEESRDITRPSRPA---DLTALAKELRELRIEETNRPMKKVTDYSSSSEE 827
Query: 744 SGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEP---AM 800
S +++EE++D E E D + + + R + + E +V + H S +
Sbjct: 828 SESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSG 887
Query: 801 TPSKEGTLIVRQT--------QSASSTLQKH----------------------------- 823
+ S+EGTL++R+T S S+ H
Sbjct: 888 SISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQ 947
Query: 824 ------------KSSSSFTPFIDPRLLQISPS----SGTTVTSVVGFSCDGMRPEAIRQD 867
+ +SFTPF+DPR+ Q SP+ ++ F+ + +R E + +
Sbjct: 948 EMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLN 1007
Query: 868 PTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSG 927
RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSG
Sbjct: 1008 EARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSG 1067
Query: 928 QGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGW 987
QGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVEKKQGW
Sbjct: 1068 QGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGW 1127
Query: 988 TTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLV 1047
TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSF +L HKPLLV
Sbjct: 1128 ITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLV 1187
Query: 1048 DLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELL 1107
DLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+HIQ +I PHAI+ILP TDGME+L
Sbjct: 1188 DLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEML 1247
Query: 1108 VCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGV 1167
VCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGV
Sbjct: 1248 VCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGV 1307
Query: 1168 FMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1212
FMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1308 FMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1352
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sapiens]
Length = 1360
Score = 1559 bits (4037), Expect = 0.0
Identities = 857/1370 (62%), Positives = 979/1370 (71%), Gaps = 168/1370 (12%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
MA+DSPA+SL +IDLS+LRDPAGIFELVE+VGNGTYGQVYKGRHVKTGQLAAIKVMDVT
Sbjct: 1 MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKK+PPG DDQLWLVMEFCGAGS+TDL+KNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGNTLKE+WIAYI REILRGL+HLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYD++SDLWS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNP PRLKSKKWSKKF SFIE CLVKN+ QRP+TEQL+KHPFIRDQPNERQVRI
Sbjct: 241 ALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDRT+KKRGEKDETEYEYSGSEEEEEE GEPSSI+N+PGESTLRRDFLRLQ
Sbjct: 301 QLKDHIDRTKKKRGEKDETEYEYSGSEEEEEE--NDSGEPSSILNLPGESTLRRDFLRLQ 358
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
NKERSEALRRQQL EQQ RE EE+KRQLLAERQKRIE+QKEQRRRLEEQQRRE+E R
Sbjct: 359 LANKERSEALRRQQL--EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELR 416
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEE-RRRAEEEKRRVE----------------- 462
+QQEREQRR +E+ RR EE R E+E RR+ EEE+R++E
Sbjct: 417 KQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYK 476
Query: 463 -------REQEYIRRQLEEEQRHLEVLQQQLLQEQ----------------------AML 493
R+ E ++RQL++E+ +L LQ Q +++ A
Sbjct: 477 RKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKE 536
Query: 494 LHDHRRPHPQHSQQPP------------PPQQE----------RSKPSFHAPEPK----- 526
+ + R + Q S P PP+ E R+ P +P+
Sbjct: 537 VEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLV 596
Query: 527 --------------AHYEPADRAREVEDRFRKTNH--SSPEAQSKQTGRVLEPPVPSRSE 570
H +P ++ T+H P S T PP+P+R E
Sbjct: 597 AVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSE--NPPLPTRIE 654
Query: 571 SFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIE 630
F S + P+VP RTTS SP L+R++SP GS Q S+ +
Sbjct: 655 KFDR----SSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPD 710
Query: 631 PRLLWERVEKLVPRPGSGSSSGSSNSGSQP----GSHPGSQSGSGERFRVRSSSKSEGSP 686
R +E + R SGSSS SS SQP GS PGSQ+GS ER RVR++SKSEGSP
Sbjct: 711 LRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSP 770
Query: 687 SQRLENAVKKPEDKKEVFRPLKPAG-----EVDLTALAKELRAV---EDVRPPHKVTDYS 738
E A KPE+ +++ RP +PA + DLTALAKELR + E RP KVTDYS
Sbjct: 771 VLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYS 830
Query: 739 SSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEP 798
SSSEES +++EE++D E E D + + + R + + E +V + H S
Sbjct: 831 SSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHA 890
Query: 799 ---AMTPSKEGTLIVRQT--------QSASSTLQKH------------------------ 823
+ + S+EGTL++R+T S S+ H
Sbjct: 891 DSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRV 950
Query: 824 -----------------KSSSSFTPFIDPRLLQISPS----SGTTVTSVVGFSCDGMRPE 862
+ +SFTPF+DPR+ Q SP+ ++ F+ + +R E
Sbjct: 951 STHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQE 1010
Query: 863 AIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLML 922
+ + RK SVVNVNPTN RP SDTPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLML
Sbjct: 1011 QAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLML 1070
Query: 923 LDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVE 982
LDRSGQGKVY LINRRRFQQMDVLEGLNVLVTISGKK+KLRVYYLSWLRN+ILHNDPEVE
Sbjct: 1071 LDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVE 1130
Query: 983 KKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVH 1042
KKQGW TVGDLEGC+HYKVVKYERIKFLVIALK++VE+YAWAPKPYHKFMAFKSF +L H
Sbjct: 1131 KKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQH 1190
Query: 1043 KPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTD 1102
KPLLVDLTVEEGQRLKVI+GS GFH +DVDSG+ YDIY+P+HIQ +I PHAI+ILP TD
Sbjct: 1191 KPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTD 1250
Query: 1103 GMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETG 1162
GME+LVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETG
Sbjct: 1251 GMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETG 1310
Query: 1163 HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1212
HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQV+FMTL R S+++W
Sbjct: 1311 HLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW 1360
>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
Length = 1312
Score = 1476 bits (3821), Expect = 0.0
Identities = 840/1356 (61%), Positives = 948/1356 (69%), Gaps = 188/1356 (13%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 RQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLE 480
+ QE+EQ+RR LE+++ R+EEE +R+ EREQEY R+QLEE QR E
Sbjct: 420 KLQEKEQQRR-------LEDMQALRREEE--------RRQAEREQEYKRKQLEE-QRQSE 463
Query: 481 VLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHY----EPADR-- 534
LQ+QL QE A L ++ Q QQ QQ++ P +P HY PAD+
Sbjct: 464 RLQRQLQQEHAYLKSLQQQ---QQQQQLQKQQQQQLLPGDR--KPLYHYGRGMNPADKPA 518
Query: 535 -AREVED--RFRKTNHS------------------------SPEAQSKQTGRVLEP---- 563
AREVE+ R K +S P +Q+ R +EP
Sbjct: 519 WAREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGP 578
Query: 564 -------------------------PVPS------------RSESFSNGNSESVHP-ALQ 585
P P+ S+ S G S +P A
Sbjct: 579 HKSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWV 638
Query: 586 RP---AEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKL 641
RP A P+VP RT+S + L+ + G + +QA + R ++S L R E+
Sbjct: 639 RPDNEAPPKVPQRTSSIATALNTSGA----GGSRPAQAVRARPRSNSAWQIYLQRRAERG 694
Query: 642 VPRPGSGSSS--GSSNSGSQPG---SHPG---------------SQSGSGERFRVRSSSK 681
P+P + G N+ S P S PG Q+GS ER RV SSK
Sbjct: 695 TPKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSK 754
Query: 682 SEGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSS 741
+ SP N K P+D + RP +PA V L KE E RPP K DYSSSS
Sbjct: 755 PDSSPVLSPGNKAK-PDDHRS--RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSS 807
Query: 742 EESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMT 801
EE E +D E+EG G DT S +G+T+SV TM+VHD E
Sbjct: 808 EEV----ESSEDDEEEGEGGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQP 859
Query: 802 PSKEGTLIVRQTQSA--------------------------------------------S 817
P GT++V++T S
Sbjct: 860 PYGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQS 919
Query: 818 STLQKHKSSSSFTPFIDPRLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVN 876
L K SSFT F+D + Q S + +T++VG +G R + ++ D RKGSVVN
Sbjct: 920 RGLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVN 976
Query: 877 VNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLIN 936
VNPTNTR S+TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI
Sbjct: 977 VNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIG 1036
Query: 937 RRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGC 996
RRRFQQMDVLEGLN+L+TISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC
Sbjct: 1037 RRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGC 1096
Query: 997 VHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQR 1056
HY+VVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQR
Sbjct: 1097 GHYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQR 1156
Query: 1057 LKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVY 1116
LKVIYGS AGFHAVDVDSG+ YDIY+P HIQ I PHAII LPNTDGME+L+CYEDEGVY
Sbjct: 1157 LKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVY 1216
Query: 1117 VNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRL 1176
VNTYGRI KDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRL
Sbjct: 1217 VNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRL 1276
Query: 1177 KFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1212
KFLCERNDKVFFASVRSGGSSQVYFMTL R +++W
Sbjct: 1277 KFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1312
>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
Length = 1332
Score = 1472 bits (3810), Expect = 0.0
Identities = 824/1355 (60%), Positives = 945/1355 (69%), Gaps = 166/1355 (12%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 RQQEREQRRR--------EQEEKRRLE-ELERRRKEEEERRRAEEEKRRVEREQEYIR-- 469
+ QE+EQ+RR +EE+R+ E E E +RK+ EE+R++E +R++++E Y++
Sbjct: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479
Query: 470 RQLEEEQRHLEVLQQQLLQEQAMLLHDHRR------------------------------ 499
+Q +++Q+ + QQQLL L+ + R
Sbjct: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK 539
Query: 500 ----------PHPQHSQQPP------PPQQERSKPS--------FHAPEPKAHYEPADRA 535
P PQ S PP PP Q +P H K + P R+
Sbjct: 540 SKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRS 599
Query: 536 REVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVH---------PALQR 586
+ ++D+ + + P + PS + NS+ PA R
Sbjct: 600 QSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVR 659
Query: 587 P---AEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQ-RNSTSSIEPRLLWERVEKLV 642
P A P+VP RT+S + L+ + G + +QA + R ++S L R E+
Sbjct: 660 PDNEAPPKVPQRTSSIATALNTSGA----GGSRPAQAVRARPRSNSAWQIYLQRRAERGT 715
Query: 643 PRPGSGSSS--GSSNSGSQPG---SHPG---------------SQSGSGERFRVRSSSKS 682
P+P + G N+ S P S PG Q+GS ER RV SSK
Sbjct: 716 PKPPGPPAQPPGPPNASSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRVGVSSKP 775
Query: 683 EGSPSQRLENAVKKPEDKKEVFRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSE 742
+ SP N K P+D + RP +PA V L KE E RPP K DYSSSSE
Sbjct: 776 DSSPVLSPGNKAK-PDDHRS--RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSE 828
Query: 743 ESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTP 802
E E +D E+EG G DT S +G+T+SV TM+VHD E P
Sbjct: 829 EV----ESSEDDEEEGEGGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPP 880
Query: 803 SKEGTLIVRQTQSA--------------------------------------------SS 818
GT++V++T S
Sbjct: 881 YGGGTMVVQRTPEEERNLLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSR 940
Query: 819 TLQKHKSSSSFTPFIDPRLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNV 877
L K SSFT F+D + Q S + +T++VG +G R + ++ D RKGSVVNV
Sbjct: 941 GLVKAPGKSSFTMFVDLGIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNV 997
Query: 878 NPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINR 937
NPTNTR S+TPEIRKYKKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI R
Sbjct: 998 NPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGR 1057
Query: 938 RRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCV 997
RRFQQMDVLEGLN+L+TISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC
Sbjct: 1058 RRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCG 1117
Query: 998 HYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRL 1057
HY+VVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRL
Sbjct: 1118 HYRVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRL 1177
Query: 1058 KVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYV 1117
KVIYGS AGFHAVDVDSG+ YDIY+P HIQ I PHAII LPNTDGME+L+CYEDEGVYV
Sbjct: 1178 KVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYV 1237
Query: 1118 NTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK 1177
NTYGRI KDVVLQWGEMPTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLK
Sbjct: 1238 NTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLK 1297
Query: 1178 FLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW 1212
FLCERNDKVFFASVRSGGSSQVYFMTL R +++W
Sbjct: 1298 FLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW 1332
>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
Length = 1295
Score = 1470 bits (3806), Expect = 0.0
Identities = 816/1334 (61%), Positives = 938/1334 (70%), Gaps = 161/1334 (12%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 RQQEREQRRR--------EQEEKRRLE-ELERRRKEEEERRRAEEEKRRVEREQEYIR-- 469
+ QE+EQ+RR +EE+R+ E E E +RK+ EE+R++E +R++++E Y++
Sbjct: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479
Query: 470 RQLEEEQRHLEVLQQQLLQEQAMLLHDHRR------------------------------ 499
+Q +++Q+ + QQQLL L+ + R
Sbjct: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK 539
Query: 500 ----------PHPQHSQQPP------PPQQERSKPS--------FHAPEPKAHYEPADRA 535
P PQ S PP PP Q +P H K + P R+
Sbjct: 540 SKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRS 599
Query: 536 REVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVH---------PALQR 586
+ ++D+ + + P + PS + NS+ PA R
Sbjct: 600 QSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVR 659
Query: 587 P---AEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVP 643
P A P+VP RT+S + L+ + G + +QA + ++ WER + ++P
Sbjct: 660 PDNEAPPKVPQRTSSIATALNTSGA----GGSRPAQAVRASNPDLRRSDPGWERSDSVLP 715
Query: 644 RPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEV 703
++ G P Q+GS ER RV SSK + SP N K P+D +
Sbjct: 716 ----------ASHGHLP------QAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS- 757
Query: 704 FRPLKPAGEVDLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADEST 763
RP +PA V L KE E RPP K DYSSSSEE E +D E+EG
Sbjct: 758 -RPGRPADFV----LLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGEGGPA 808
Query: 764 SGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA------- 816
G DT S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 809 EGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERNLLHA 864
Query: 817 -------------------------------------SSTLQKHKSSSSFTPFIDPRLLQ 839
S L K SSFT F+D + Q
Sbjct: 865 DSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDLGIYQ 924
Query: 840 ISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRF 898
S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKYKKRF
Sbjct: 925 PGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKYKKRF 981
Query: 899 NSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGK 958
NSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+TISGK
Sbjct: 982 NSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGK 1041
Query: 959 KDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSV 1018
++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIALKSSV
Sbjct: 1042 RNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKSSV 1101
Query: 1019 EVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVY 1078
EVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDSG+ Y
Sbjct: 1102 EVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSY 1161
Query: 1079 DIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSV 1138
DIY+P HIQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEMPTSV
Sbjct: 1162 DIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSV 1221
Query: 1139 AYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQ 1198
AYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQ
Sbjct: 1222 AYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQ 1281
Query: 1199 VYFMTLGRTSLLSW 1212
VYFMTL R +++W
Sbjct: 1282 VYFMTLNRNCIMNW 1295
>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
Length = 1303
Score = 1467 bits (3798), Expect = 0.0
Identities = 815/1338 (60%), Positives = 937/1338 (70%), Gaps = 161/1338 (12%)
Query: 1 MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
M + +PA+SL DIDLS+LRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE
Sbjct: 1 MGDPAPARSLDDIDLSALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE 60
Query: 61 DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNT 120
DEEEEIK EINMLKKYSHHRNIATYYGAFIKKSPPG+DDQLWLVMEFCGAGS+TDLVKNT
Sbjct: 61 DEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNT 120
Query: 121 KGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
KGN LKED IAYI REILRGLAHLH H VIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR
Sbjct: 121 KGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSD+WS GITAIEMAEGAPPLCDMHPMR
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 241 ALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRI 300
ALFLIPRNPPPRLKSKKWSKKF FI+ CL+K Y+ RP TEQLLK PFIRDQP ERQVRI
Sbjct: 241 ALFLIPRNPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRI 300
Query: 301 QLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQ 360
QLKDHIDR+RKKRGEK+ETEYEYSGSEEE++ E EGEPSSI+NVPGESTLRR+FLRLQ
Sbjct: 301 QLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGE-EGEPSSIMNVPGESTLRREFLRLQ 359
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREAR 420
QENK SEAL++QQ LQ+QQ R+ E + + LL +RQ+RIE+QKE+RRR+EEQQRRERE R
Sbjct: 360 QENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQR 419
Query: 421 RQQEREQRRR--------EQEEKRRLE-ELERRRKEEEERRRAEEEKRRVEREQEYIR-- 469
+ QE+EQ+RR +EE+R+ E E E +RK+ EE+R++E +R++++E Y++
Sbjct: 420 KLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSL 479
Query: 470 RQLEEEQRHLEVLQQQLLQEQAMLLHDHRR------------------------------ 499
+Q +++Q+ + QQQLL L+ + R
Sbjct: 480 QQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKPAWAREVEERTRMNKQQNSPLAK 539
Query: 500 ----------PHPQHSQQPP------PPQQERSKPS--------FHAPEPKAHYEPADRA 535
P PQ S PP PP Q +P H K + P R+
Sbjct: 540 SKPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRS 599
Query: 536 REVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVH---------PALQR 586
+ ++D+ + + P + PS + NS+ PA R
Sbjct: 600 QSLQDQPTRNLAAFPASHDPDPAIPAPTATPSARGAVIRQNSDPTSEGPGPSPNPPAWVR 659
Query: 587 P---AEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVP 643
P A P+VP RT+S + L+ + G + +QA + ++ WER + ++P
Sbjct: 660 PDNEAPPKVPQRTSSIATALNTSGA----GGSRPAQAVRASNPDLRRSDPGWERSDSVLP 715
Query: 644 RPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEV 703
++ G P Q+GS ER RV SSK + SP N K P+D +
Sbjct: 716 ----------ASHGHLP------QAGSLERNRVGVSSKPDSSPVLSPGNKAK-PDDHRS- 757
Query: 704 FRPLKPAGEVDLTA----LAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGA 759
RP +PA L KE E RPP K DYSSSSEE E +D E+EG
Sbjct: 758 -RPGRPASYKRAIGEDFVLLKERTLDEAPRPPKKAMDYSSSSEEV----ESSEDDEEEGE 812
Query: 760 DESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSA--- 816
G DT S +G+T+SV TM+VHD E P GT++V++T
Sbjct: 813 GGPAEGSRDTPGGRS----DGDTDSVSTMVVHDVEEITGTQPPYGGGTMVVQRTPEEERN 868
Query: 817 -----------------------------------------SSTLQKHKSSSSFTPFIDP 835
S L K SSFT F+D
Sbjct: 869 LLHADSNGYTNLPDVVQPSHSPTENSKGQSPPSKDGSGDYQSRGLVKAPGKSSFTMFVDL 928
Query: 836 RLLQISPSSGTT-VTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKY 894
+ Q S + +T++VG +G R + ++ D RKGSVVNVNPTNTR S+TPEIRKY
Sbjct: 929 GIYQPGGSGDSIPITALVGG--EGTRLDQLQYD-VRKGSVVNVNPTNTRAHSETPEIRKY 985
Query: 895 KKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVT 954
KKRFNSEILCAALWGVNLLVGTE+GLMLLDRSGQGKVY LI RRRFQQMDVLEGLN+L+T
Sbjct: 986 KKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLIT 1045
Query: 955 ISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIAL 1014
ISGK++KLRVYYLSWLRNKILHNDPEVEKKQGWTTVGD+EGC HY+VVKYERIKFLVIAL
Sbjct: 1046 ISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIAL 1105
Query: 1015 KSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDS 1074
KSSVEVYAWAPKPYHKFMAFKSF +L H+PLLVDLTVEEGQRLKVIYGS AGFHAVDVDS
Sbjct: 1106 KSSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDS 1165
Query: 1075 GSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEM 1134
G+ YDIY+P HIQ I PHAII LPNTDGME+L+CYEDEGVYVNTYGRI KDVVLQWGEM
Sbjct: 1166 GNSYDIYIPVHIQSQITPHAIIFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEM 1225
Query: 1135 PTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG 1194
PTSVAYI SNQ MGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG
Sbjct: 1226 PTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSG 1285
Query: 1195 GSSQVYFMTLGRTSLLSW 1212
GSSQVYFMTL R +++W
Sbjct: 1286 GSSQVYFMTLNRNCIMNW 1303
>gi|118600963 Nik related kinase [Homo sapiens]
Length = 1582
Score = 405 bits (1040), Expect = e-112
Identities = 240/586 (40%), Positives = 336/586 (57%), Gaps = 55/586 (9%)
Query: 14 DLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE------------- 60
DL L DP GIF L + +G GTYG++Y G H KTG A+KVM+ +
Sbjct: 14 DLGHLPDPTGIFSLDKTIGLGTYGRIYLGLHEKTGAFTAVKVMNARKTPLPEIGRRVRVN 73
Query: 61 -----------DEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCG 109
DEEE+++ E+N+L+KYS H+NI ++YGAF K SPPG QLW+VME C
Sbjct: 74 KYQKSVGWRYSDEEEDLRTELNLLRKYSFHKNIVSFYGAFFKLSPPGQRHQLWMVMELCA 133
Query: 110 AGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKL 169
AGS+TD+V+ T +LKEDWIAYI REIL+GLAHLH H VIHRDIKGQNVLLT NAEVKL
Sbjct: 134 AGSVTDVVRMTSNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKL 193
Query: 170 VDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEG 229
VDFGVSAQ+ RT GRRN+FIGTPYWMAPEVI CDE+P +YDYRSD+WS GITAIEMAEG
Sbjct: 194 VDFGVSAQVSRTNGRRNSFIGTPYWMAPEVIDCDEDPRRSYDYRSDVWSVGITAIEMAEG 253
Query: 230 APPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289
APPLC++ P+ ALF+I R P +KS WS+KF +F+E C +KN++ RP++ +L+HPF+
Sbjct: 254 APPLCNLQPLEALFVILRESAPTVKSSGWSRKFHNFMEKCTIKNFLFRPTSANMLQHPFV 313
Query: 290 RDQPNERQVRIQLKDHIDRTRKKRGEKD-ETEYEYSGSEEEEEEVPEQEGEPS---SIVN 345
RD NER V L H+ KKR +K +E + +E+ V G PS ++
Sbjct: 314 RDIKNERHVVESLTRHLTGIIKKRQKKGIPLIFEREEAIKEQYTVRRFRG-PSCTHELLR 372
Query: 346 VPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKR-----QLLAERQKRIE 400
+P S R LR+ + L ++ Q Q L++ + R Q L K ++
Sbjct: 373 LPTSSRCRP--LRVLHGEPSQPRWLPDREEPQVQALQQLQGAARVFMPLQALDSAPKPLK 430
Query: 401 QQKEQRRRLEEQQR------REREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRA 454
Q + +RL+ R + +A+ + + + + RR + + + R
Sbjct: 431 GQAQAPQRLQGAARVFMPLQAQVKAKASKPLQMQIKAPPRLRRAARVLMPLQAQVRAPRL 490
Query: 455 EEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQE 514
+ + +V ++Q+ + Q E Q +V ++ Q+Q P Q Q P QQ
Sbjct: 491 LQVQSQVSKKQQ-AQTQTSEPQDLDQVPEEFQGQDQV--------PEQQRQGQAPEQQQR 541
Query: 515 RSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRV 560
++ PE + A EV+++ + + EA+ ++ RV
Sbjct: 542 HNQ----VPEQELEQNQAPEQPEVQEQAAEPAQAETEAEEPESLRV 583
Score = 280 bits (717), Expect = 5e-75
Identities = 155/424 (36%), Positives = 238/424 (56%), Gaps = 58/424 (13%)
Query: 841 SPSSGTTVTSVVGFSCDGMRPEAIR--QDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRF 898
SPS G+ +++ F+ + + ++ ++ S VNVNP P P I Y+K F
Sbjct: 1149 SPSKGSGMSADANFASAILYAGFVEVPEESPKQPSEVNVNPLYVSPACKKPLIHMYEKEF 1208
Query: 899 NSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGK 958
SEI C +LWGVNLL+GT S L L+DRSG+ + LI RR F+Q+ VLE LN+L+TISG
Sbjct: 1209 TSEICCGSLWGVNLLLGTRSNLYLMDRSGKADITKLIRRRPFRQIQVLEPLNLLITISGH 1268
Query: 959 KDKLRVYYLSWLRNKILHNDPEVEKKQ--------GWTTVGDLEGCVHYKVVKYERIKFL 1010
K++LRVY+L+WLRNKIL+NDPE +++Q + L GC H+ V+++E ++
Sbjct: 1269 KNRLRVYHLTWLRNKILNNDPESKRRQEEMLKTEEACKAIDKLTGCEHFSVLQHEETTYI 1328
Query: 1011 VIALKSSVEVYAWAPK---------------------------------------PYHKF 1031
IALKSS+ +YAWAPK P ++F
Sbjct: 1329 AIALKSSIHLYAWAPKSFDESTAIKVCIDQSADSEGDYMSYQAYIRILAKIQAADPVNRF 1388
Query: 1032 ---------MAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYL 1082
+ K F L HKP+ VDL + +RLK+ + S G+H +D +S + D+ L
Sbjct: 1389 KRPDELLHLLKLKVFPTLDHKPVTVDLAIGSEKRLKIFFSSADGYHLIDAESEVMSDVTL 1448
Query: 1083 PTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIR 1142
P + I P IIILP+ G+ +++ + E + V ++ K ++ W ++P+S+A+
Sbjct: 1449 PKNPLEIIIPQNIIILPDCLGIGMMLTFNAEALSVEANEQLFKKILEMWKDIPSSIAFEC 1508
Query: 1143 SNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFM 1202
+ +T GWG+KAIE+RS+++ L+ + ++L+FLC R DK+FF S S+VYFM
Sbjct: 1509 TQRTTGWGQKAIEVRSLQSRVLESELKRRSIKKLRFLCTRGDKLFFTSTLRNHHSRVYFM 1568
Query: 1203 TLGR 1206
TLG+
Sbjct: 1569 TLGK 1572
Score = 34.7 bits (78), Expect = 0.57
Identities = 59/233 (25%), Positives = 93/233 (39%), Gaps = 50/233 (21%)
Query: 352 LRRDFLRLQQENKERSEALRRQQLLQE-----------QQLREQEEYK---RQLLAERQK 397
L RD LR N S+ L Q L E +Q RE++ RQ LA+R
Sbjct: 643 LSRDLLRAPNSNN--SKPLGPLQTLMENLSSNRFYSQPEQAREKKSKVSTLRQALAKRLS 700
Query: 398 RIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457
+ + R E+ + + EARRQ R QRR E + EEL + K++E+ +E
Sbjct: 701 PKRFRAKSSWRPEKLELSDLEARRQ--RRQRRWEDIFNQHEEELRQVDKDKEDESSDNDE 758
Query: 458 -------KRRVEREQEYIR--RQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQP 508
+ ++E + YI +++E ++R V Q DH H + S
Sbjct: 759 VFHSIQAEVQIEPLKPYISNPKKIEVQERSPSVPNNQ----------DHAH-HVKFSSSV 807
Query: 509 PPPQ--QERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGR 559
P ++ KP + R+ + + + SS E +S TGR
Sbjct: 808 PQRSLLEQAQKP----------IDIRQRSSQNRQNWLAASESSSEEESPVTGR 850
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 306 bits (783), Expect = 1e-82
Identities = 157/311 (50%), Positives = 206/311 (66%), Gaps = 11/311 (3%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHH 79
DP+ +E+ E +G GTYG+V+K + K GQ AA+K++D D +EEI+ E N+LK S H
Sbjct: 16 DPSDTWEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEAEYNILKALSDH 75
Query: 80 RNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN--TKGNTLKEDWIAYISREI 137
N+ +YG + KK + D+LWLV+E C GS+TDLVK +G + E IAYI E
Sbjct: 76 PNVVRFYGIYFKKDKV-NGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEA 134
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L GL HLH + IHRD+KG N+LLT VKLVDFGVSAQL T RRNT +GTP+WMAP
Sbjct: 135 LMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAP 194
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVIAC++ D TYD R D WS GITAIE+ +G PPL D+HPMRALF IPRNPPP+L+ +
Sbjct: 195 EVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPE 254
Query: 258 -WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI-----RDQPNERQVR--IQLKDHIDRT 309
WS +F FI CL K+Y +RP+ +LL+H FI +D ++Q+ I + + T
Sbjct: 255 LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVMLQKQLTEFIGIHQCMGGT 314
Query: 310 RKKRGEKDETE 320
K R E+ T+
Sbjct: 315 EKARRERIHTK 325
Score = 37.0 bits (84), Expect = 0.11
Identities = 47/271 (17%), Positives = 103/271 (38%), Gaps = 18/271 (6%)
Query: 289 IRDQPNERQVRIQLKDHIDRTRKKRGE----KDETEYEYSGSEEEEEEVPEQEGEPSSIV 344
I+++ E + IQ RK+R E K+ S++E + E S V
Sbjct: 1078 IQEKRKESAIIIQSAARGHLVRKQRKEIVDMKNTAVTTIQTSDQEFDYKKNFENTRESFV 1137
Query: 345 NVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKE 404
E+ + + + N + S ++ + + ++ + + K++ E
Sbjct: 1138 KKQAENAISANERFISAPNNKGSVSVVKTSTFKPEEETTNAVESNNRVYQTPKKMNNVYE 1197
Query: 405 QRRRLE------EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEE---EERRRAE 455
+ + E E +++ + +E R+ ++E+ ++ +R EE EE + A
Sbjct: 1198 EEVKQEFYLVGPEVSPKQKSVKDLEENSNLRKVEKEEAMIQSYYQRYTEERNCEESKAAY 1257
Query: 456 EEKRRVEREQEYIRRQLEEEQRHLE-----VLQQQLLQEQAMLLHDHRRPHPQHSQQPPP 510
E++ + Y L E + + L Q+ + + A + ++ + P
Sbjct: 1258 LERKAISERPSYPVPWLAENETSFKKTLEPTLSQRSIYQNANSMEKEKKTSVVTQRAPIC 1317
Query: 511 PQQERSKPSFHAPEPKAHYEPADRAREVEDR 541
Q+E H + EP +A+E ED+
Sbjct: 1318 SQEEGRGRLRHETVKERQVEPVTQAQEEEDK 1348
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 296 bits (758), Expect = 8e-80
Identities = 157/330 (47%), Positives = 210/330 (63%), Gaps = 15/330 (4%)
Query: 13 IDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINM 72
+ L SL DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGH--DDQLWLVMEFCGAGSITDLVKNTK--GNTLKED 128
L+ +H N+ +YG F K H QLWLV+E C GS+T+LVK G L E
Sbjct: 75 LQFLPNHPNVVKFYGMFYKAD---HCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEA 131
Query: 129 WIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTF 188
I+YI L GL HLH + +IHRD+KG N+LLT VKLVDFGVSAQL T RRNT
Sbjct: 132 MISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTS 191
Query: 189 IGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
+GTP+WMAPEVIAC++ D++YD R D+WS GITAIE+ +G PPL DMHP++ LF IPRN
Sbjct: 192 VGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRN 251
Query: 249 PPPR-LKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPN-----ERQVRIQL 302
PPP L +KW ++F FI CL+K++ +RPS LL HPFI+ ++Q+ L
Sbjct: 252 PPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVL 311
Query: 303 KD--HIDRTRKKRGEKDETEYEYSGSEEEE 330
+D H + K R E+ T Y + E+
Sbjct: 312 QDQKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 296 bits (758), Expect = 8e-80
Identities = 157/330 (47%), Positives = 210/330 (63%), Gaps = 15/330 (4%)
Query: 13 IDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINM 72
+ L SL DP +E++E +G GTYG+VYK + + G LAA+K++D D +EEI+ E N+
Sbjct: 15 LGLESLPDPTDTWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEAEYNI 74
Query: 73 LKKYSHHRNIATYYGAFIKKSPPGH--DDQLWLVMEFCGAGSITDLVKNTK--GNTLKED 128
L+ +H N+ +YG F K H QLWLV+E C GS+T+LVK G L E
Sbjct: 75 LQFLPNHPNVVKFYGMFYKAD---HCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEA 131
Query: 129 WIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTF 188
I+YI L GL HLH + +IHRD+KG N+LLT VKLVDFGVSAQL T RRNT
Sbjct: 132 MISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTS 191
Query: 189 IGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN 248
+GTP+WMAPEVIAC++ D++YD R D+WS GITAIE+ +G PPL DMHP++ LF IPRN
Sbjct: 192 VGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRN 251
Query: 249 PPPR-LKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPN-----ERQVRIQL 302
PPP L +KW ++F FI CL+K++ +RPS LL HPFI+ ++Q+ L
Sbjct: 252 PPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVL 311
Query: 303 KD--HIDRTRKKRGEKDETEYEYSGSEEEE 330
+D H + K R E+ T Y + E+
Sbjct: 312 QDQKHQNPVAKTRHERMHTRRPYHVEDAEK 341
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 269 bits (688), Expect = 1e-71
Identities = 160/419 (38%), Positives = 240/419 (57%), Gaps = 27/419 (6%)
Query: 6 PAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEE 64
P + L +D SL + P +F+++E +G G+YG VYK H +TGQ+ AIK + V D +E
Sbjct: 10 PRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE 69
Query: 65 EIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT 124
IK EI+++++ ++ YYG++ K + LW+VME+CGAGS++D+++ + T
Sbjct: 70 IIK-EISIMQQCDSP-HVVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNKT 120
Query: 125 LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGR 184
L ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+ +
Sbjct: 121 LTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK 180
Query: 185 RNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFL 244
RNT IGTP+WMAPEVI + Y+ +D+WS GITAIEMAEG PP D+HPMRA+F+
Sbjct: 181 RNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 245 IPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLK 303
IP NPPP K + WS F F++ CLVK+ QR + QLL+HPF+R +R +
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLIN 295
Query: 304 DHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGE--STLRRDFLRLQQ 361
+ +D + KR E + E + +++EE E E + ++V G+ T+R
Sbjct: 296 EAMD-VKLKRQESQQREVD----QDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDG 350
Query: 362 ENK--ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRRERE 418
N E + L Q L + ++E + + R + ++ K EQ+ +E +
Sbjct: 351 ANTMIEHDDTLPSQ--LGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQ 407
Score = 33.1 bits (74), Expect = 1.6
Identities = 24/100 (24%), Positives = 41/100 (41%), Gaps = 11/100 (11%)
Query: 732 HKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAA----SSLNLSNGETESVKT 787
++ D +ES + + DD E DE SG RA ++ +++ T+ T
Sbjct: 295 NEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTM-VRAVGDEMGTVRVASTMTDGANT 353
Query: 788 MIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSS 827
MI HDD PS+ GT+++ K + +
Sbjct: 354 MIEHDDT------LPSQLGTMVINAEDEEEEGTMKRRDET 387
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 267 bits (683), Expect = 4e-71
Identities = 150/338 (44%), Positives = 209/338 (61%), Gaps = 21/338 (6%)
Query: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKY 76
S R+P FEL++ +G+GTYG VYK R+V TG+LAAIKV+ + E+ + + ++ K
Sbjct: 8 SRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKD 67
Query: 77 SHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISRE 136
H NI Y+G+++++ D+LW+ MEFCG GS+ D+ T L E IAY+SRE
Sbjct: 68 CKHPNIVAYFGSYLRR------DKLWICMEFCGGGSLQDIYHVT--GPLSELQIAYVSRE 119
Query: 137 ILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 196
L+GL +LH +HRDIKG N+LLT+N VKL DFGVSAQ+ T+ +R +FIGTPYWMA
Sbjct: 120 TLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMA 179
Query: 197 PEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRLK 254
PEV A + Y+ DLW+ GITAIE+AE PP+ D+HPMRALFL+ ++ PP+LK
Sbjct: 180 PEVAAVERK--GGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLK 237
Query: 255 SK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
K KWS F F++ L KN +RP+ E+LL+HPF+ Q R + I+L D ++
Sbjct: 238 DKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV-TQHLTRSLAIELLDKVN------ 290
Query: 314 GEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGEST 351
D + Y ++ E V S+ NV E T
Sbjct: 291 -NPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKT 327
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 259 bits (663), Expect = 8e-69
Identities = 152/351 (43%), Positives = 214/351 (60%), Gaps = 28/351 (7%)
Query: 5 SPAKSLVDIDLSSL-RDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE 63
+P L + SL + P +F+++E +G G+YG V+K H ++GQ+ AIK + V D +
Sbjct: 6 APKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ 65
Query: 64 EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGN 123
E IK EI+++++ + YYG++ K + LW+VME+CGAGS++D+++ +
Sbjct: 66 EIIK-EISIMQQCDSPY-VVKYYGSYFKNT------DLWIVMEYCGAGSVSDIIR-LRNK 116
Query: 124 TLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVG 183
TL ED IA I + L+GL +LH IHRDIK N+LL KL DFGV+ QL T+
Sbjct: 117 TLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMA 176
Query: 184 RRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALF 243
+RNT IGTP+WMAPEVI + Y+ +D+WS GIT+IEMAEG PP D+HPMRA+F
Sbjct: 177 KRNTVIGTPFWMAPEVI-----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIF 231
Query: 244 LIPRNPPPRL-KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQL 302
+IP NPPP K + WS F F++ CLVKN QR + QLL+HPFI+ N + V I L
Sbjct: 232 MIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK---NAKPVSI-L 287
Query: 303 KDHIDRT---RKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGES 350
+D I + KR E+ + E EEEEE E E + ++V ES
Sbjct: 288 RDLITEAMEIKAKRHEEQQREL-----EEEEENSDEDELDSHTMVKTSVES 333
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 256 bits (655), Expect = 7e-68
Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)
Query: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62
++P + DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 2 EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
Query: 63 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122
I+ EI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 59 FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
Query: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
L E IAY+ RE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Query: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242
+R +FIGTPYWMAPEV A ++N Y+ D+W+ GITAIE+ E PP+ D+HPMRAL
Sbjct: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
Query: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299
FL+ ++ PP+LK K KWS F +F++ L KN +RP+ E+LL H F+ R +
Sbjct: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
Query: 300 IQLKDHIDR--TRKKRGEKDETEYE 322
++L D ++ E D+ ++E
Sbjct: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 256 bits (655), Expect = 7e-68
Identities = 140/325 (43%), Positives = 209/325 (64%), Gaps = 20/325 (6%)
Query: 4 DSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DE 62
++P + DI R+P +ELV+ VG+GTYG VYK R+V TG+LAA+K++ + D+
Sbjct: 2 EAPLRPAADI---LRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDD 58
Query: 63 EEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKG 122
I+ EI M+K+ H NI Y+G+++ + ++LW+ ME+CG GS+ D+ T
Sbjct: 59 FSLIQQEIFMVKECKHC-NIVAYFGSYLSR------EKLWICMEYCGGGSLQDIYHVT-- 109
Query: 123 NTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTV 182
L E IAY+ RE L+GLA+LH +HRDIKG N+LLT++ +VKL DFGV+A++ T+
Sbjct: 110 GPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATI 169
Query: 183 GRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRAL 242
+R +FIGTPYWMAPEV A ++N Y+ D+W+ GITAIE+ E PP+ D+HPMRAL
Sbjct: 170 AKRKSFIGTPYWMAPEVAAVEKN--GGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
Query: 243 FLIPRN--PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVR 299
FL+ ++ PP+LK K KWS F +F++ L KN +RP+ E+LL H F+ R +
Sbjct: 228 FLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALA 287
Query: 300 IQLKDHIDR--TRKKRGEKDETEYE 322
++L D ++ E D+ ++E
Sbjct: 288 VELLDKVNNPDNHAHYTEADDDDFE 312
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 252 bits (644), Expect = 1e-66
Identities = 143/330 (43%), Positives = 202/330 (61%), Gaps = 24/330 (7%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
DP +F ++ +G G++G+VYKG T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
I Y+G+++K + +LW++ME+ G GS DL+K L+E +IA I REI
Sbjct: 75 SPY-ITRYFGSYLKST------KLWIIMEYLGGGSALDLLKP---GPLEETYIATILREI 124
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 125 LKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 184
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD+++D+WS GITAIE+A+G PP D+HPMR LFLIP+N PP L+ +
Sbjct: 185 EVI-----KQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH 239
Query: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
SK F F+E CL K+ RP+ ++LLKH FI + +L D R K
Sbjct: 240 -SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYKRW------KS 292
Query: 318 ETEYEYSGSEEEEEEVPEQEGEPSSIVNVP 347
E E S SE+ + + ++GE I P
Sbjct: 293 EGHGEESSSEDSDIDGEAEDGEQGPIWTFP 322
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 248 bits (633), Expect = 2e-65
Identities = 138/319 (43%), Positives = 197/319 (61%), Gaps = 18/319 (5%)
Query: 16 SSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINML 73
+++ DP +F +E +G G++G+V+KG +T Q+ AIK++D+ EDE E+I+ EI +L
Sbjct: 15 NNIADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVL 74
Query: 74 KKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYI 133
+ + YYG+++K S +LW++ME+ G GS DL++ E IA +
Sbjct: 75 SQCDSSY-VTKYYGSYLKGS------KLWIIMEYLGGGSALDLLR---AGPFDEFQIATM 124
Query: 134 SREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPY 193
+EIL+GL +LH IHRDIK NVLL+E +VKL DFGV+ QL T +RNTF+GTP+
Sbjct: 125 LKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF 184
Query: 194 WMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRL 253
WMAPEVI + YD ++D+WS GITAIE+A+G PP DMHPMR LFLIP+N PP L
Sbjct: 185 WMAPEVI-----QQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL 239
Query: 254 KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKR 313
++K F FI+ CL K+ RP+ ++LLKH FI + +L D R + +
Sbjct: 240 VG-DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAEG 298
Query: 314 GEKDETEYEYSGSEEEEEE 332
DE++ E S SE E
Sbjct: 299 HSDDESDSEGSDSESTSRE 317
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 243 bits (619), Expect = 1e-63
Identities = 138/319 (43%), Positives = 194/319 (60%), Gaps = 24/319 (7%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 79 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 128
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 129 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 188
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++D+WS GITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 189 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 242
Query: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
+SK F+E CL K RP+ ++LLKH FI + +L D R K
Sbjct: 243 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRW------KA 296
Query: 318 ETEYEYSGSEEEEEEVPEQ 336
E ++ S SE+ + E Q
Sbjct: 297 EQSHDDSSSEDSDAETDGQ 315
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 243 bits (619), Expect = 1e-63
Identities = 138/319 (43%), Positives = 194/319 (60%), Gaps = 24/319 (7%)
Query: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDV--TEDEEEEIKLEINMLKKYS 77
DP +F +E +G G++G+V+KG +T ++ AIK++D+ EDE E+I+ EI +L +
Sbjct: 31 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 90
Query: 78 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 137
+ YYG+++K D +LW++ME+ G GS DL++ L E IA I REI
Sbjct: 91 SPY-VTKYYGSYLK------DTKLWIIMEYLGGGSALDLLEP---GPLDETQIATILREI 140
Query: 138 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 197
L+GL +LH IHRDIK NVLL+E+ EVKL DFGV+ QL T +RNTF+GTP+WMAP
Sbjct: 141 LKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAP 200
Query: 198 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKK 257
EVI + YD ++D+WS GITAIE+A G PP ++HPM+ LFLIP+N PP L+
Sbjct: 201 EVIK-----QSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGN- 254
Query: 258 WSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKD 317
+SK F+E CL K RP+ ++LLKH FI + +L D R K
Sbjct: 255 YSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRW------KA 308
Query: 318 ETEYEYSGSEEEEEEVPEQ 336
E ++ S SE+ + E Q
Sbjct: 309 EQSHDDSSSEDSDAETDGQ 327
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 241 bits (616), Expect = 2e-63
Identities = 149/401 (37%), Positives = 224/401 (55%), Gaps = 22/401 (5%)
Query: 17 SLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTE-DEEEEIKLEINMLKK 75
SL+DP FEL++ VG GTYG VYK R T +LAA+K++ + D+ ++ EI +L++
Sbjct: 8 SLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
Query: 76 YSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISR 135
H N+ Y G++++ +D+LW+ MEFCG GS+ ++ T L+E IAY+ R
Sbjct: 68 -CRHPNVVAYIGSYLR------NDRLWICMEFCGGGSLQEIYHAT--GPLEERQIAYVCR 118
Query: 136 EILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 195
E L+GL HLH IHRDIKG N+LLT +VKL DFGVS +L +V +R +FIGTPYWM
Sbjct: 119 EALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWM 178
Query: 196 APEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN--PPPRL 253
APEV A + Y+ D+W+ GITAIE+ E PPL +HPMRAL L+ ++ PP+L
Sbjct: 179 APEVAAVERK--GGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKL 236
Query: 254 KSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKK 312
+ K +W++ F F++ L KN +RP+ E+LL+HPF Q R + QL D
Sbjct: 237 RDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQ-LPRALLTQLLDKASDPHLG 295
Query: 313 RGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRR 372
++ E E + + + G+ P E + ++ ++ ++ L
Sbjct: 296 TPSPEDCELE---TYDMFPDTIHSRGQHGPAERTPSEIQFHQ--VKFGAPRRKETDPL-N 349
Query: 373 QQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQ 413
+ +E L +EE LL Q+ +E++ R E Q
Sbjct: 350 EPWEEEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQ 390
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 239 bits (609), Expect = 2e-62
Identities = 145/389 (37%), Positives = 215/389 (55%), Gaps = 28/389 (7%)
Query: 10 LVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLE 69
+VD D+ + RDP ++L++ +G GTYG+V+K R +G L A+K++ + D++ +
Sbjct: 3 VVDPDIFN-RDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK 61
Query: 70 INMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDW 129
++ K H NI Y+G+++ +LW+ MEFCGAGS+ D+ + T +L E
Sbjct: 62 EILILKTCRHANIVAYHGSYLWLQ------KLWICMEFCGAGSLQDIYQVT--GSLSELQ 113
Query: 130 IAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFI 189
I+Y+ RE+L+GLA+LH IHRDIKG N+L+ + EV+L DFG+SAQ+ T+ RR +FI
Sbjct: 114 ISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFI 173
Query: 190 GTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRN- 248
GTPYWMAPEV A Y+ D+WS GITAIE+AE PPL D+HP+R LFL+ ++
Sbjct: 174 GTPYWMAPEVAAVALK--GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG 231
Query: 249 -PPPRLKSK-KWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHI 306
PPRLK K KWS F +FI+ L K+ +RPS ++L H + R + + L D +
Sbjct: 232 YQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKL 291
Query: 307 DRTRKKRGEKDETEYEYSGSEEEEEEVPE------QEGEPSSIVNVPGESTLRRDFLRLQ 360
K D E+EE E+P + SS + +P RR +
Sbjct: 292 KNPGKGPSIGD--------IEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRK 343
Query: 361 QENKERSEALRRQQLLQEQQLREQEEYKR 389
E +L + LR K+
Sbjct: 344 LRGMETRPPANTARLQPPRDLRSSSPRKQ 372
Score = 34.7 bits (78), Expect = 0.57
Identities = 37/135 (27%), Positives = 61/135 (45%), Gaps = 16/135 (11%)
Query: 911 NLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWL 970
+LL+G E G+ +L+R+ Q ++ R + + NVL+++SGK L + + L
Sbjct: 513 HLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSIN--NVLMSLSGKTPHLYSHSILGL 570
Query: 971 --------RNKILHNDPE---VEKKQGWTTVGDLEGCVHYKVVKYERI--KFLVIALKSS 1017
N I H P K T + D +GC V + FL AL++S
Sbjct: 571 LERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETS 630
Query: 1018 VEVYAWAPKPYHKFM 1032
V + W +P +KF+
Sbjct: 631 VVLLQWY-QPMNKFL 644
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,074,892
Number of Sequences: 37866
Number of extensions: 2752324
Number of successful extensions: 86470
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1885
Number of HSP's successfully gapped in prelim test: 1617
Number of HSP's that attempted gapping in prelim test: 18217
Number of HSP's gapped (non-prelim): 22880
length of query: 1212
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1098
effective length of database: 13,930,794
effective search space: 15296011812
effective search space used: 15296011812
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.