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Search of human proteins with 115387104
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
(518 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 1042 0.0
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 370 e-102
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 358 9e-99
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 345 4e-95
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 345 6e-95
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 344 1e-94
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 343 2e-94
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 343 2e-94
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 325 5e-89
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 325 8e-89
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 299 5e-81
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 276 4e-74
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 268 9e-72
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 259 4e-69
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 220 2e-57
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 187 2e-47
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 161 2e-39
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 161 2e-39
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 161 2e-39
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 158 1e-38
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 150 3e-36
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 150 3e-36
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 150 3e-36
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 150 4e-36
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 150 4e-36
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 136 4e-32
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 136 4e-32
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 136 4e-32
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 129 8e-30
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 129 8e-30
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 1042 bits (2695), Expect = 0.0
Identities = 518/518 (100%), Positives = 518/518 (100%)
Query: 1 MFLRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPAT 60
MFLRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPAT
Sbjct: 1 MFLRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPAT 60
Query: 61 GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMEC 120
GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMEC
Sbjct: 61 GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMEC 120
Query: 121 INNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAW 180
INNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAW
Sbjct: 121 INNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAW 180
Query: 181 NYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATG 240
NYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATG
Sbjct: 181 NYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATG 240
Query: 241 QFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGA 300
QFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGA
Sbjct: 241 QFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGA 300
Query: 301 LMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHL 360
LMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHL
Sbjct: 301 LMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHL 360
Query: 361 ERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPV 420
ERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPV
Sbjct: 361 ERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPV 420
Query: 421 MSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELP 480
MSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELP
Sbjct: 421 MSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELP 480
Query: 481 FGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF 518
FGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF
Sbjct: 481 FGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF 518
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 370 bits (949), Expect = e-102
Identities = 198/460 (43%), Positives = 283/460 (61%), Gaps = 12/460 (2%)
Query: 58 PATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIREREDE 114
P+TG VI +++V+ AV+ A+AAF++ W + R R+L A +I
Sbjct: 59 PSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTY 118
Query: 115 IATMECINNGKS-IFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGV 173
+A +E ++NGK + +D+D+ +CL YYAG A G+ I + G F YTR EP+GV
Sbjct: 119 LAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGV 178
Query: 174 CVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVV 233
C I WN+P + +WK PALA GN +V K + TP++AL +A + EAG PPG+ N+V
Sbjct: 179 CGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIV 238
Query: 234 QG-GAATGQFLCQHPDVAKVSFTGSVPTGMKI-MEMSAKGIKPVTLELGGKSPLIIFSDC 291
G G G + H DV KV+FTGS G I + + +K VTLELGGKSP II SD
Sbjct: 239 PGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDA 298
Query: 292 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 351
DM+ AV+ A A F QGQ CC G+R FVQ++I D+F E V + + +G+P T
Sbjct: 299 DMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQ 358
Query: 352 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTC 411
GP ++ +++LG++ K++GAK+LCGG I GY+++P V + +D MT
Sbjct: 359 GPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADR------GYFIQPTVFGDVQDGMTI 412
Query: 412 VKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN 471
KEEIFGPVM IL F T EV+ RAN++T+GLAA VFT+D+ +A+ + LQAGT ++N
Sbjct: 413 AKEEIFGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNC 472
Query: 472 YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 511
Y+V + PFGGYK SG GRE G ++ Y+++KTV V++
Sbjct: 473 YDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKV 512
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 358 bits (918), Expect = 9e-99
Identities = 192/473 (40%), Positives = 284/473 (60%), Gaps = 12/473 (2%)
Query: 45 EPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRIL 101
+ A + T P TG VI +V+ AV+ A+ AF++ W + ER R+L
Sbjct: 46 QDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLL 105
Query: 102 LEAARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGEHIQLPG 160
A ++ +A++E ++NGK E+ LD+D + Y+AG A G+ I + G
Sbjct: 106 NRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIPMDG 165
Query: 161 GSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIY 220
F +TR EP+GVC I WN+P + WK APALA GN +V K + TP+SAL LA +
Sbjct: 166 QHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLI 225
Query: 221 SEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA-KGIKPVTLE 278
EAG PPG+ N++ G G G + QH DV KV+FTGS G I + + +K VTLE
Sbjct: 226 KEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLE 285
Query: 279 LGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQR 338
LGGKSP I+ +D DM +AV+ A F GQ CC G+R FV++ I ++F E V++ ++
Sbjct: 286 LGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERTVEKAKQ 345
Query: 339 IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMR 398
K+G+P DT+ GP +++ ERVLG++++ +++GAK+LCGG+ + G++++
Sbjct: 346 RKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGER------GFFIK 399
Query: 399 PCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRV 458
P V +DDM KEEIFGPV + F EV+ERAN+T +GLAA VFTRD+ +A
Sbjct: 400 PTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYF 459
Query: 459 VAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 511
LQAGT ++N YN+ PFGG+K+SG GRE G ++ Y+++KTV +++
Sbjct: 460 TQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTIKV 512
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 345 bits (886), Expect = 4e-95
Identities = 203/518 (39%), Positives = 292/518 (56%), Gaps = 25/518 (4%)
Query: 3 LRAGLAALSPLLRSLRPSPVAAMS---TGTFVVSQPLNYRGGARVEPADASGTEKAFEPA 59
++A AAL L L PSP + T F+ ++ N G RV P + PA
Sbjct: 12 VKADPAALMASLHLL-PSPTPNLEIKYTKIFINNEWQNSESG-RVFPV--------YNPA 61
Query: 60 TGRVIATFTCSGEKEVNLAVQNAKAAFK---IWSQKSGMERCRILLEAARIIREREDEIA 116
TG + + + +++ AVQ A+ AF +W + ER R+L + A ++ +A
Sbjct: 62 TGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLA 121
Query: 117 TMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCV 175
TME +N GK +A +D+ + YYAG A + G I + G F +TR EP+GVC
Sbjct: 122 TMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCG 181
Query: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
I WN+P + +WK APAL CGN +V KP+ TP+SAL + + EAG PPG+ N++ G
Sbjct: 182 QIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPG 241
Query: 236 -GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG-IKPVTLELGGKSPLIIFSDCDM 293
G G + H + K++FTGS G I E + + +K VTLELGGKSP IIF+D D+
Sbjct: 242 YGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADL 301
Query: 294 NNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGP 353
+ AV+ A F QGQ C G+R+FV++ I ++F V++ +R +G P T GP
Sbjct: 302 DYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGP 361
Query: 354 LINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVK 413
I++ ++L ++ +GAK+ CGG + G+++ P V +N DDM K
Sbjct: 362 QIDKKQYNKILELIQSGVAEGAKLECGGKGLG------RKGFFIEPTVFSNVTDDMRIAK 415
Query: 414 EEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYN 473
EEIFGPV IL F T EV+ERAN++ FGL A VFT DI +A V + +QAGT +IN YN
Sbjct: 416 EEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYN 475
Query: 474 VSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 511
+ PFGG+K SG GRE G + YS++KTV V++
Sbjct: 476 ALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKI 513
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 345 bits (885), Expect = 6e-95
Identities = 199/498 (39%), Positives = 291/498 (58%), Gaps = 19/498 (3%)
Query: 25 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA 84
M+ V P G A+ + T + P G VI + + +V+ AV AK
Sbjct: 411 MAVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKD 470
Query: 85 AFKI--WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCL 141
AF+ W + S +R R++ A ++ + ++E+AT+E ++ G A + + +S Q
Sbjct: 471 AFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTF 530
Query: 142 EYYAGLAASMAGEHIQL----PGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALAC 197
Y+AG + G I + P + TR+EP+GVC I WNYP + SWK+A LA
Sbjct: 531 RYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAA 590
Query: 198 GNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTG 256
GN +V KP+ TP++AL AE+ +AG+P G+ NV+ G G+ GQ L HPDV K+ FTG
Sbjct: 591 GNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTG 650
Query: 257 SVPTGMKIMEMSA-KGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNG 315
S G IM+ A +K V+LELGGKSPLIIF+DCD+N AV+ + + F +G+ C
Sbjct: 651 STEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAA 710
Query: 316 TRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGA 375
R+FV+ I D+F VV++ +++K+G+PL DT GP + HL +++ + + ++GA
Sbjct: 711 GRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGA 770
Query: 376 KVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSF---DTEAEV 432
++CGG+ VP + G++ P V T+ D M KEE FGPVM I F D +A V
Sbjct: 771 TLVCGGN-QVP-----RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDA-V 823
Query: 433 LERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRE 492
L RAN T FGLA+GVFTRDI +A V +LQAGT F+N YN + V PFGG+K+SGFG++
Sbjct: 824 LSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKD 883
Query: 493 NGRVTIEYYSQLKTVCVE 510
G + Y ++KTV E
Sbjct: 884 LGEAALNEYLRVKTVTFE 901
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 344 bits (883), Expect = 1e-94
Identities = 190/467 (40%), Positives = 276/467 (59%), Gaps = 12/467 (2%)
Query: 56 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIRERE 112
F PAT + +++V+ AV+ A+ AF+I W ER R+L + A +I
Sbjct: 41 FNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDR 100
Query: 113 DEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL 171
+ATME +N GK A L D+ + L Y AG A + G I + G F YTR EP+
Sbjct: 101 LLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPI 160
Query: 172 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 231
GVC I WN+P + WK PAL+CGN +V KP+ TP++AL +A + EAG PPG+ N
Sbjct: 161 GVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVN 220
Query: 232 VVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG-IKPVTLELGGKSPLIIFS 289
+V G G G + H D+ KV+FTGS G I E + K +K VTLELGGKSP I+ +
Sbjct: 221 IVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLA 280
Query: 290 DCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 349
D D++NAV+ A F QGQ C +R+FV++ I D+F V++ ++ +G+PL
Sbjct: 281 DADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGV 340
Query: 350 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 409
GP I++ +++L ++ K++GAK+ CGG P GY+++P V +N D+M
Sbjct: 341 TQGPQIDKEQYDKILDLIESGKKEGAKLECGGG------PWGNKGYFVQPTVFSNVTDEM 394
Query: 410 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 469
KEEIFGPV I+ F + +V++RAN+T +GL+AGVFT+DI +A + + LQAGT ++
Sbjct: 395 RIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWV 454
Query: 470 NNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVES 516
N Y V + PFGG+K SG GRE G Y+++KTV V++ S
Sbjct: 455 NCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS 501
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 343 bits (881), Expect = 2e-94
Identities = 179/460 (38%), Positives = 284/460 (61%), Gaps = 4/460 (0%)
Query: 55 AFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDE 114
+++P+TG V SG+ E+ AV+ A+ AF WS +S ER R+L + A ++ + +E
Sbjct: 27 SYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEE 86
Query: 115 IATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPG-GSFGYTRREPLG 172
A E + GK++ AR +DI S Q ++A + E Q+ G YT R P+G
Sbjct: 87 FAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVG 146
Query: 173 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNV 232
V I WN P + +WK APA+A GN ++ KPS T V+A +L ++ +AGVPPG+ N+
Sbjct: 147 VAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNI 206
Query: 233 VQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDC 291
V G G G+ L HP+V +SFTGS PT +I ++SA K ++LELGGK+P IIF D
Sbjct: 207 VFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDA 266
Query: 292 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 351
+++ + + ++F QG++C +R+FVQK I +F + V+ T++ K+G P +
Sbjct: 267 NLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSI 326
Query: 352 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP-KLKDGYYMRPCVLTNCRDDMT 410
G LI++ HLE+V +VK A +GA++ CG + P + + GY+M P V+T+ +D+
Sbjct: 327 GALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESC 386
Query: 411 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 470
C+ EEIFGPV ++ FD+E EV+ERAN+ +GLAA V++ ++ R HRV +LQ+G + N
Sbjct: 387 CMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTN 446
Query: 471 NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 510
+ + + LPFGG K SG GRE + + ++++++KT+ V+
Sbjct: 447 CWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 343 bits (880), Expect = 2e-94
Identities = 192/475 (40%), Positives = 282/475 (59%), Gaps = 17/475 (3%)
Query: 47 ADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI--WSQKSGMERCRILLEA 104
AD T P G I + + +V+ AV AK AF+ W + + ER R++
Sbjct: 454 ADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRL 513
Query: 105 ARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGEHIQL----P 159
A ++ E ++E+AT+E +++G A + I +S Q Y+AG + G I + P
Sbjct: 514 ADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARP 573
Query: 160 GGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEI 219
+ +T++EPLGVC I WNYP + +WKSA LA GN +V KP+ TP++AL AE+
Sbjct: 574 NRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAEL 633
Query: 220 YSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSA-KGIKPVTL 277
+AG P G+ N++ G G GQ L +HPD+ K+ FTGS P G +IM+ A +K V+L
Sbjct: 634 SVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSL 693
Query: 278 ELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQ 337
ELGGKSPLIIF+DC+++ AV+ + A F +G+ C R+FV++ I D+F VV++ +
Sbjct: 694 ELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIK 753
Query: 338 RIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYM 397
++KIGDPL T GP ++ HLE++L + + ++GA ++ GG + G++M
Sbjct: 754 KMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGG------RQVQRPGFFM 807
Query: 398 RPCVLTNCRDDMTCVKEEIFGPVMSILSFDTE--AEVLERANDTTFGLAAGVFTRDIQRA 455
P V T+ D M KEE FGP+M I F VL+RAN T +GLA+GVFTRDI +A
Sbjct: 808 EPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKA 867
Query: 456 HRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 510
V +L+AGT FIN YN + V PFGG K+SGFG++ G + Y + KTV +E
Sbjct: 868 MYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLE 922
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 325 bits (834), Expect = 5e-89
Identities = 176/419 (42%), Positives = 249/419 (59%), Gaps = 9/419 (2%)
Query: 96 ERCRILLEAARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGE 154
ER R+L + A ++ +ATME +N GK +A +D+ + YYAG A + G
Sbjct: 5 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 64
Query: 155 HIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL 214
I + G F +TR EP+GVC I WN+P + +WK APAL CGN +V KP+ TP+SAL
Sbjct: 65 TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSAL 124
Query: 215 LLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG-I 272
+ + EAG PPG+ N++ G G G + H + K++FTGS G I E + + +
Sbjct: 125 YMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNL 184
Query: 273 KPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEV 332
K VTLELGGKSP IIF+D D++ AV+ A F QGQ C G+R+FV++ I ++F
Sbjct: 185 KRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRS 244
Query: 333 VKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLK 392
V++ +R +G P T GP I++ ++L ++ +GAK+ CGG +
Sbjct: 245 VERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLG------R 298
Query: 393 DGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDI 452
G+++ P V +N DDM KEEIFGPV IL F T EV+ERAN++ FGL A VFT DI
Sbjct: 299 KGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDI 358
Query: 453 QRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 511
+A V + +QAGT +IN YN + PFGG+K SG GRE G + YS++KTV V++
Sbjct: 359 NKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKI 417
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 325 bits (832), Expect = 8e-89
Identities = 173/462 (37%), Positives = 270/462 (58%), Gaps = 12/462 (2%)
Query: 58 PATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIREREDE 114
P+T I + +V+ AV+ A+ AF+ W + + R R+L + A ++
Sbjct: 54 PSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRAT 113
Query: 115 IATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGV 173
+A +E ++ GK A +D++ + L Y+AG A + G+ I +TR EP+GV
Sbjct: 114 LAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGV 173
Query: 174 CVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVV 233
C I WN+P + WK APAL CGN MV KP+ TP++AL L + EAG PPG+ N+V
Sbjct: 174 CGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIV 233
Query: 234 QG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG-IKPVTLELGGKSPLIIFSDC 291
G G G + HP + K++FTGS G + E +++ +K VTLELGGK+P I+ +D
Sbjct: 234 PGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADA 293
Query: 292 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 351
D++ AV+ A F QGQ C +RVFV++++ +F V+ ++ +GDP T
Sbjct: 294 DLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQ 353
Query: 352 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTC 411
GP I++ +++L ++ K++GAK+ CGG ED G +++P V + D+M
Sbjct: 354 GPQIDQKQFDKILELIESGKKEGAKLECGGSAM--EDK----GLFIKPTVFSEVTDNMRI 407
Query: 412 VKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN 471
KEEIFGPV IL F + EV++RAN T +GL A VFT+++ +A ++ + L++GT +IN
Sbjct: 408 AKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINC 467
Query: 472 YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGD 513
YN + PFGG+K SG GRE G + Y+++KTV +++GD
Sbjct: 468 YNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGD 509
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 299 bits (765), Expect = 5e-81
Identities = 188/516 (36%), Positives = 270/516 (52%), Gaps = 59/516 (11%)
Query: 3 LRAGLAALSPLLRSLRPSPVAAMS---TGTFVVSQPLNYRGGARVEPADASGTEKAFEPA 59
++A AAL L L PSP + T F+ ++ N G RV P + PA
Sbjct: 12 VKADPAALMASLHLL-PSPTPNLEIKYTKIFINNEWQNSESG-RVFPV--------YNPA 61
Query: 60 TGRVIATFTCSGEKEVNLAVQNAKAAFK---IWSQKSGMERCRILLEAARIIREREDEIA 116
TG + + + +++ AVQ A+ AF +W + ER R+L + A ++ +A
Sbjct: 62 TGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLA 121
Query: 117 TMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCV 175
TME +N GK +A +D+ + YYAG A + G I + G F +TR EP+GVC
Sbjct: 122 TMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCG 181
Query: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
I WN+P + +WK APAL CGN +V KP+ TP+SAL + + E G ++Q
Sbjct: 182 QIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEVG------KLIQE 235
Query: 236 GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNN 295
A +K VTLELGGKSP IIF+D D++
Sbjct: 236 AAGRSN------------------------------LKRVTLELGGKSPNIIFADADLDY 265
Query: 296 AVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLI 355
AV+ A F QGQ C G+R+FV++ I ++F V++ +R +G P T GP I
Sbjct: 266 AVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQI 325
Query: 356 NRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEE 415
++ ++L ++ +GAK+ CGG + G+++ P V +N DDM KEE
Sbjct: 326 DKKQYNKILELIQSGVAEGAKLECGGKGLG------RKGFFIEPTVFSNVTDDMRIAKEE 379
Query: 416 IFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVS 475
IFGPV IL F T EV+ERAN++ FGL A VFT DI +A V + +QAGT +IN YN
Sbjct: 380 IFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNAL 439
Query: 476 PVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 511
+ PFGG+K SG GRE G + YS++KTV V++
Sbjct: 440 NAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKI 475
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 276 bits (705), Expect = 4e-74
Identities = 158/460 (34%), Positives = 251/460 (54%), Gaps = 58/460 (12%)
Query: 55 AFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDE 114
+++P+TG V SG+ E+ AV+ A+ AF WS +S ER R+L + A ++ + +E
Sbjct: 27 SYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEE 86
Query: 115 IATMECINNGKSIFEAR-LDIDISWQCLEYYAGLAASMAGEHIQLPG-GSFGYTRREPLG 172
A E + GK++ AR +DI S Q ++A + E Q+ G YT R P+G
Sbjct: 87 FAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVG 146
Query: 173 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNV 232
V I WN P + +WK APA+A GN ++ KPS T V+A +L ++ +AGVPPG+ N+
Sbjct: 147 VAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNI 206
Query: 233 VQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDC 291
V G G G+ L HP+V +SFTGS PT +I ++SA K ++LELGGK+P IIF D
Sbjct: 207 VFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDA 266
Query: 292 DMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRM 351
+++ + + ++F N R +V++
Sbjct: 267 NLDECIPATVRSSF-------ANQVRSYVKR----------------------------- 290
Query: 352 GPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP-KLKDGYYMRPCVLTNCRDDMT 410
A +GA++ CG + P + + GY+M P V+T+ +D+
Sbjct: 291 ------------------ALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESC 332
Query: 411 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 470
C+ EEIFGPV ++ FD+E EV+ERAN+ +GLAA V++ ++ R HRV +LQ+G + N
Sbjct: 333 CMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTN 392
Query: 471 NYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 510
+ + + LPFGG K SG GRE + + ++++++KT+ V+
Sbjct: 393 CWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 268 bits (685), Expect = 9e-72
Identities = 160/466 (34%), Positives = 251/466 (53%), Gaps = 12/466 (2%)
Query: 49 ASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARII 108
A+ T +PA+G + G +E AV+ A AF W + S ER +L + ++
Sbjct: 72 AAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLM 131
Query: 109 REREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSF-GYTR 167
+ +D++A + +GK + EA +I S LE+++ A + G+ I P
Sbjct: 132 IQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVL 191
Query: 168 REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPP 227
++P+GV I WN+P + + K ALA G +V KP+ TP SAL LAE+ S+AG+P
Sbjct: 192 KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPS 251
Query: 228 GLFNVV----QGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 283
G++NV+ + G+ +C P V+K+SFTGS TG ++ +A +K V++ELGG +
Sbjct: 252 GVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLA 311
Query: 284 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQR-IKIG 342
P I+F +++ AV GA+ + F GQ C + VQ+ I D F + + ++ +++G
Sbjct: 312 PFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVG 371
Query: 343 DPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVL 402
+ E T GPLIN +E+V V A +GA V+ GG + +L ++ P +L
Sbjct: 372 NGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH-----QLGKNFF-EPTLL 425
Query: 403 TNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAEL 462
N DM C EE FGP+ ++ FDTE E + AN GLA +++D + RV +L
Sbjct: 426 CNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQL 485
Query: 463 QAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 508
+ G +N +S VE PFGG K+SG GRE + I+ Y +LK VC
Sbjct: 486 EVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 531
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 259 bits (662), Expect = 4e-69
Identities = 160/479 (33%), Positives = 251/479 (52%), Gaps = 25/479 (5%)
Query: 49 ASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARII 108
A+ T +PA+G + G +E AV+ A AF W + S ER +L + ++
Sbjct: 72 AAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLM 131
Query: 109 REREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSF-GYTR 167
+ +D++A + +GK + EA +I S LE+++ A + G+ I P
Sbjct: 132 IQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVL 191
Query: 168 REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIY------- 220
++P+GV I WN+P + + K ALA G +V KP+ TP SAL LAE+
Sbjct: 192 KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDL 251
Query: 221 ------SEAGVPPGLFNVV----QGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAK 270
S+AG+P G++NV+ + G+ +C P V+K+SFTGS TG ++ +A
Sbjct: 252 DPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAAN 311
Query: 271 GIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTE 330
+K V++ELGG +P I+F +++ AV GA+ + F GQ C + VQ+ I D F +
Sbjct: 312 SVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVK 371
Query: 331 EVVKQTQR-IKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDP 389
+ ++ +++G+ E T GPLIN +E+V V A +GA V+ GG +
Sbjct: 372 AFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH----- 426
Query: 390 KLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFT 449
+L ++ P +L N DM C EE FGP+ ++ FDTE E + AN GLA ++
Sbjct: 427 QLGKNFF-EPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYS 485
Query: 450 RDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC 508
+D + RV +L+ G +N +S VE PFGG K+SG GRE + I+ Y +LK VC
Sbjct: 486 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVC 544
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 220 bits (561), Expect = 2e-57
Identities = 151/512 (29%), Positives = 253/512 (49%), Gaps = 16/512 (3%)
Query: 3 LRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGR 62
+RA + +S ++S P+ +A S + V + L + GG VE + PAT
Sbjct: 10 VRARILQVSSKVKS-SPTWYSASSFSSSVPTVKL-FIGGKFVESKSDKWID-IHNPATNE 66
Query: 63 VIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECIN 122
VI + + E++ A+ + K AF W+ S + R ++LL ++I+E EIA + +
Sbjct: 67 VIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLE 126
Query: 123 NGKSIFEARLDIDISWQCLEYYAGLAASMAGEHI-QLPGGSFGYTRREPLGVCVGIGAWN 181
GK++ +A D+ Q +E+ + + M GE + + Y+ R PLGVC GI +N
Sbjct: 127 QGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFN 186
Query: 182 YPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQ 241
+P I W A+ CGN + KPS P + +LLA++ ++G P G N++ G
Sbjct: 187 FPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVN 246
Query: 242 FLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGAL 301
F+C HPD+ +SF GS G I E ++ K V +G K+ ++ D + N + +
Sbjct: 247 FICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLV 306
Query: 302 MANFLTQGQVC-CNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHL 360
A F GQ C T V V + K+ E+V+ + +++ +GPLI
Sbjct: 307 GAAFGAAGQRCMALSTAVLVGE--AKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAK 364
Query: 361 ERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPV 420
ERV + ++GA +L G + ++G ++ P +++N + +MTC KEEIFGPV
Sbjct: 365 ERVCNLIDSGTKEGASILLDGRKIKVKG--YENGNFVGPTIISNVKPNMTCYKEEIFGPV 422
Query: 421 MSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELP 480
+ +L +T E ++ N+ +G +FT + A + + G +N PV LP
Sbjct: 423 LVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN--VPIPVPLP 480
Query: 481 ---FGGYKKSGFGREN--GRVTIEYYSQLKTV 507
F G + S G N G+ I++Y+QLKT+
Sbjct: 481 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTI 512
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 187 bits (476), Expect = 2e-47
Identities = 128/463 (27%), Positives = 222/463 (47%), Gaps = 20/463 (4%)
Query: 58 PATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIAT 117
PA IA + + V+ A+ A+KIW+ +R I+ + +RE+ + +
Sbjct: 71 PANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGS 130
Query: 118 MECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRRE---PLGVC 174
+ + GK + E ++ +Y GL+ + G LP G+ E P+G+
Sbjct: 131 LVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPI--LPSERSGHALIEQWNPVGLV 188
Query: 175 VGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSAL----LLAEIYSEAGVPPGLF 230
I A+N+P + W +A A+ CGN ++K +P T + ++ ++A++ + +P +
Sbjct: 189 GIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAIC 248
Query: 231 NVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSD 290
++ GGA G + + V +SFTGS G ++ M + LELGG + +I F D
Sbjct: 249 SLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFED 308
Query: 291 CDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTR 350
D++ V AL A T GQ C R+F+ + I D+ + K +I++G+P +
Sbjct: 309 ADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVL 368
Query: 351 MGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMT 410
GPL + + LG V+ AK++G V+ GG + + G Y+ P ++T D +
Sbjct: 369 YGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMD------RPGNYVEPTIVTGLGHDAS 422
Query: 411 CVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFIN 470
E F P++ + F E EV N+ GL++ +FT+D+ R R + + C I
Sbjct: 423 IAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGP-KGSDCGIV 481
Query: 471 NYNV--SPVEL--PFGGYKKSGFGRENGRVTIEYYSQLKTVCV 509
N N+ S E+ FGG K +G GRE+G + Y + T +
Sbjct: 482 NVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 161 bits (407), Expect = 2e-39
Identities = 126/444 (28%), Positives = 210/444 (47%), Gaps = 24/444 (5%)
Query: 74 EVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLD 133
+++ AV+ A+AAF + R + L R+I+E+E E+ + K+ + A +
Sbjct: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
Query: 134 -----IDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIAS 188
++ ++ AA E Y EPLGV + IG WNYPF +
Sbjct: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122
Query: 189 WKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHP 247
A+A GN++V KPS + A LLA I + + L+ V+ GG T + L +
Sbjct: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERF 181
Query: 248 DVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLT 307
D + +TGS G IM +AK + PVTLELGGKSP + +CD++ A + F+
Sbjct: 182 D--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
Query: 308 QGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV 367
GQ C + I ++ E++ K + G+ + G +I+ H +RV+G +
Sbjct: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298
Query: 368 KVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFD 427
+G KV GG D + Y+ P +LT+ ++EEIFGPV+ I+
Sbjct: 299 -----EGQKVAYGG----TGDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346
Query: 428 TEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGGYK 485
+ E ++ N LA +F+ + + +++AE +G N+ +++ LPFGG
Sbjct: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406
Query: 486 KSGFGRENGRVTIEYYSQLKTVCV 509
SG G +G+ + E +S ++ V
Sbjct: 407 NSGMGSYHGKKSFETFSHRRSCLV 430
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 161 bits (407), Expect = 2e-39
Identities = 126/444 (28%), Positives = 210/444 (47%), Gaps = 24/444 (5%)
Query: 74 EVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLD 133
+++ AV+ A+AAF + R + L R+I+E+E E+ + K+ + A +
Sbjct: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
Query: 134 -----IDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIAS 188
++ ++ AA E Y EPLGV + IG WNYPF +
Sbjct: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122
Query: 189 WKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHP 247
A+A GN++V KPS + A LLA I + + L+ V+ GG T + L +
Sbjct: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERF 181
Query: 248 DVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLT 307
D + +TGS G IM +AK + PVTLELGGKSP + +CD++ A + F+
Sbjct: 182 D--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
Query: 308 QGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV 367
GQ C + I ++ E++ K + G+ + G +I+ H +RV+G +
Sbjct: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298
Query: 368 KVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFD 427
+G KV GG D + Y+ P +LT+ ++EEIFGPV+ I+
Sbjct: 299 -----EGQKVAYGG----TGDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346
Query: 428 TEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGGYK 485
+ E ++ N LA +F+ + + +++AE +G N+ +++ LPFGG
Sbjct: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406
Query: 486 KSGFGRENGRVTIEYYSQLKTVCV 509
SG G +G+ + E +S ++ V
Sbjct: 407 NSGMGSYHGKKSFETFSHRRSCLV 430
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 161 bits (407), Expect = 2e-39
Identities = 126/444 (28%), Positives = 210/444 (47%), Gaps = 24/444 (5%)
Query: 74 EVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLD 133
+++ AV+ A+AAF + R + L R+I+E+E E+ + K+ + A +
Sbjct: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
Query: 134 -----IDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIAS 188
++ ++ AA E Y EPLGV + IG WNYPF +
Sbjct: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122
Query: 189 WKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHP 247
A+A GN++V KPS + A LLA I + + L+ V+ GG T + L +
Sbjct: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERF 181
Query: 248 DVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLT 307
D + +TGS G IM +AK + PVTLELGGKSP + +CD++ A + F+
Sbjct: 182 D--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
Query: 308 QGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV 367
GQ C + I ++ E++ K + G+ + G +I+ H +RV+G +
Sbjct: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298
Query: 368 KVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFD 427
+G KV GG D + Y+ P +LT+ ++EEIFGPV+ I+
Sbjct: 299 -----EGQKVAYGG----TGDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346
Query: 428 TEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGGYK 485
+ E ++ N LA +F+ + + +++AE +G N+ +++ LPFGG
Sbjct: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406
Query: 486 KSGFGRENGRVTIEYYSQLKTVCV 509
SG G +G+ + E +S ++ V
Sbjct: 407 NSGMGSYHGKKSFETFSHRRSCLV 430
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 158 bits (399), Expect = 1e-38
Identities = 129/439 (29%), Positives = 215/439 (48%), Gaps = 23/439 (5%)
Query: 57 EPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIA 116
+P TG +A+ + ++V AV+ A+ AFK WS G+ R + L A +I++ + +
Sbjct: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
Query: 117 TMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCV 175
T+E + G+++ E R D+ ++ Q L Y+A + AS E + G+ EP+GV
Sbjct: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHA-IQASTQEEALA------GW---EPMGVIG 170
Query: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
I + F W+ PALA G +V P +P + LLLA++ E G PG+ NV+ G
Sbjct: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APLLLAQLAGELGPFPGILNVLSG 229
Query: 236 GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNN 295
A+ L P + KV+F G+ G + A + L LG +S L++ D+++
Sbjct: 230 PASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDS 289
Query: 296 AVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLI 355
AV+G + A + +G G R+ +Q+ + D+ + ++ R++ G L MG
Sbjct: 290 AVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGAR- 345
Query: 356 NRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEE 415
+ V FV+ A+ QGA+V GD+ E P + P +++N C + E
Sbjct: 346 GAAACDLVQRFVREAQSQGAQVFQAGDV-PSERP------FYPPTLVSNLPPASPCAQVE 398
Query: 416 IFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVS 475
+ PV+ F T E L AN T G +A V++ + +A + LQ GT +IN + +
Sbjct: 399 VPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLR 458
Query: 476 PVELPFGGYKKSGFGRENG 494
+P GG K+SG G
Sbjct: 459 DPSVPTGGCKESGCSWHGG 477
Score = 68.9 bits (167), Expect = 1e-11
Identities = 76/277 (27%), Positives = 114/277 (41%), Gaps = 15/277 (5%)
Query: 6 GLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIA 65
GLA S L P A G FV G R + A + + + ++G +
Sbjct: 507 GLAVPSTLPAGPEIGPSPAPPYGLFV---------GGRFQ-APGARSSRPIRDSSGNLHG 556
Query: 66 TFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGK 125
G K++ AV+ A AF W+ +S R +L A + R+ +A+ G
Sbjct: 557 YVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLAS-RLERQGA 615
Query: 126 SIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTR-REPLGVCVGIGAWNYPF 184
+ A ++++S + L + G G +Q+ G R REPLGV + +P
Sbjct: 616 ELKAAEAEVELSARRLRAW-GARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 674
Query: 185 QIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFL 243
APALA GN +V PS P+ AL + + + P GL NVV G + L
Sbjct: 675 LAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDHLTRCL 733
Query: 244 CQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELG 280
H DV + + GS + SA +KPV G
Sbjct: 734 ALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 770
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 150 bits (379), Expect = 3e-36
Identities = 125/458 (27%), Positives = 220/458 (48%), Gaps = 36/458 (7%)
Query: 61 GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIR-EREDEIATME 119
G +A F + + +N A++ A AA K W K +R +I L+AA ++ R EI
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 147
Query: 120 CINNGKSIFEARLDIDISWQCLEYY---AGLAASMAGEH-IQLPGGSFGYTRREPLGVCV 175
+ GK++ +A +ID + + ++++ A A + G+ I +P + R G
Sbjct: 148 MVGQGKTVIQA--EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVA 205
Query: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
I +N+ + APAL GN +++KPS +++ + I EAG+PP + V
Sbjct: 206 AISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA 264
Query: 236 -GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP------VTLELGGKSPLIIF 288
G G + + ++FTGSVPT + + A+ + + E GGK+ +
Sbjct: 265 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 324
Query: 289 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLE- 347
D+ + V G L + F GQ C +R++V + + ++++ RIK+GDP +
Sbjct: 325 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDF 384
Query: 348 DTRMGPLINRPHLERVLGFVKVAKEQ-GAKVLCGGDIYVPEDPKLKD--GYYMRPCVLTN 404
T +I+ R+ +++ A+ +L GG K D GY++ PC++ +
Sbjct: 385 GTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGG--------KCDDSVGYFVEPCIVES 436
Query: 405 CRDDMTCVKEEIFGPVMSILSF--DTEAEVLERANDTT-FGLAAGVFTRD---IQRAHRV 458
+KEEIFGPV+S+ + D E L+ + TT +GL VF++D +Q A +V
Sbjct: 437 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 496
Query: 459 VAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGRENG 494
+ AG +IN+ + + + PFGG + SG + G
Sbjct: 497 LRN-AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 150 bits (379), Expect = 3e-36
Identities = 125/458 (27%), Positives = 220/458 (48%), Gaps = 36/458 (7%)
Query: 61 GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIR-EREDEIATME 119
G +A F + + +N A++ A AA K W K +R +I L+AA ++ R EI
Sbjct: 28 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 87
Query: 120 CINNGKSIFEARLDIDISWQCLEYY---AGLAASMAGEH-IQLPGGSFGYTRREPLGVCV 175
+ GK++ +A +ID + + ++++ A A + G+ I +P + R G
Sbjct: 88 MVGQGKTVIQA--EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVA 145
Query: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
I +N+ + APAL GN +++KPS +++ + I EAG+PP + V
Sbjct: 146 AISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA 204
Query: 236 -GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP------VTLELGGKSPLIIF 288
G G + + ++FTGSVPT + + A+ + + E GGK+ +
Sbjct: 205 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 264
Query: 289 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLE- 347
D+ + V G L + F GQ C +R++V + + ++++ RIK+GDP +
Sbjct: 265 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDF 324
Query: 348 DTRMGPLINRPHLERVLGFVKVAKEQ-GAKVLCGGDIYVPEDPKLKD--GYYMRPCVLTN 404
T +I+ R+ +++ A+ +L GG K D GY++ PC++ +
Sbjct: 325 GTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGG--------KCDDSVGYFVEPCIVES 376
Query: 405 CRDDMTCVKEEIFGPVMSILSF--DTEAEVLERANDTT-FGLAAGVFTRD---IQRAHRV 458
+KEEIFGPV+S+ + D E L+ + TT +GL VF++D +Q A +V
Sbjct: 377 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 436
Query: 459 VAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGRENG 494
+ AG +IN+ + + + PFGG + SG + G
Sbjct: 437 LRN-AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 150 bits (379), Expect = 3e-36
Identities = 125/458 (27%), Positives = 220/458 (48%), Gaps = 36/458 (7%)
Query: 61 GRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIR-EREDEIATME 119
G +A F + + +N A++ A AA K W K +R +I L+AA ++ R EI
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 147
Query: 120 CINNGKSIFEARLDIDISWQCLEYY---AGLAASMAGEH-IQLPGGSFGYTRREPLGVCV 175
+ GK++ +A +ID + + ++++ A A + G+ I +P + R G
Sbjct: 148 MVGQGKTVIQA--EIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLEGFVA 205
Query: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
I +N+ + APAL GN +++KPS +++ + I EAG+PP + V
Sbjct: 206 AISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPA 264
Query: 236 -GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKP------VTLELGGKSPLIIF 288
G G + + ++FTGSVPT + + A+ + + E GGK+ +
Sbjct: 265 DGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVH 324
Query: 289 SDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLE- 347
D+ + V G L + F GQ C +R++V + + ++++ RIK+GDP +
Sbjct: 325 RSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDF 384
Query: 348 DTRMGPLINRPHLERVLGFVKVAKEQ-GAKVLCGGDIYVPEDPKLKD--GYYMRPCVLTN 404
T +I+ R+ +++ A+ +L GG K D GY++ PC++ +
Sbjct: 385 GTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGG--------KCDDSVGYFVEPCIVES 436
Query: 405 CRDDMTCVKEEIFGPVMSILSF--DTEAEVLERANDTT-FGLAAGVFTRD---IQRAHRV 458
+KEEIFGPV+S+ + D E L+ + TT +GL VF++D +Q A +V
Sbjct: 437 KDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKV 496
Query: 459 VAELQAGTCFINNYNVSPV--ELPFGGYKKSGFGRENG 494
+ AG +IN+ + + + PFGG + SG + G
Sbjct: 497 LRN-AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 150 bits (378), Expect = 4e-36
Identities = 122/439 (27%), Positives = 209/439 (47%), Gaps = 30/439 (6%)
Query: 75 VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-- 132
+ L V+ + AF + R + L R+++ERE +I T + KS F
Sbjct: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
Query: 133 ------DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQI 186
+ID + L + + A +++ L Y + +PLGV + IGAWNYPF +
Sbjct: 61 VITVLGEIDFMLENLPEW--VTAKPVKKNV-LTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117
Query: 187 ASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAA-TGQFLCQ 245
A+A GNA++ KPS + +A +LA++ + + L+ V+ GG T + L Q
Sbjct: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ 176
Query: 246 HPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 305
D + +TG+ G +ME +AK + PVTLELGGKSP I DCD++ + +
Sbjct: 177 RFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234
Query: 306 LTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLG 365
+ GQ C + + + ++ + +K+T + G+ + E +IN H +R+L
Sbjct: 235 MNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFYGENIKESPDYERIINLRHFKRILS 293
Query: 366 FVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILS 425
+ +G K+ GG+ D + Y+ P VLT+ ++EEIFGP++ I+
Sbjct: 294 LL-----EGQKIAFGGE----TDEATR---YIAPTVLTDVDPKTKVMQEEIFGPILPIVP 341
Query: 426 FDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGG 483
E + N+ LA VF+ + + R++ E +G N+ + + PFGG
Sbjct: 342 VKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGG 401
Query: 484 YKKSGFGRENGRVTIEYYS 502
SG G +G+ + + +S
Sbjct: 402 VGSSGMGAYHGKHSFDTFS 420
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 150 bits (378), Expect = 4e-36
Identities = 122/439 (27%), Positives = 209/439 (47%), Gaps = 30/439 (6%)
Query: 75 VNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARL-- 132
+ L V+ + AF + R + L R+++ERE +I T + KS F
Sbjct: 1 MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQE 60
Query: 133 ------DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQI 186
+ID + L + + A +++ L Y + +PLGV + IGAWNYPF +
Sbjct: 61 VITVLGEIDFMLENLPEW--VTAKPVKKNV-LTMLDEAYIQPQPLGVVLIIGAWNYPFVL 117
Query: 187 ASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAA-TGQFLCQ 245
A+A GNA++ KPS + +A +LA++ + + L+ V+ GG T + L Q
Sbjct: 118 TIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQY-LDQDLYIVINGGVEETTELLKQ 176
Query: 246 HPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANF 305
D + +TG+ G +ME +AK + PVTLELGGKSP I DCD++ + +
Sbjct: 177 RFD--HIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKY 234
Query: 306 LTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLG 365
+ GQ C + + + ++ + +K+T + G+ + E +IN H +R+L
Sbjct: 235 MNCGQTCIAPDYILCEASLQNQIVWK-IKETVKEFYGENIKESPDYERIINLRHFKRILS 293
Query: 366 FVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILS 425
+ +G K+ GG+ D + Y+ P VLT+ ++EEIFGP++ I+
Sbjct: 294 LL-----EGQKIAFGGE----TDEATR---YIAPTVLTDVDPKTKVMQEEIFGPILPIVP 341
Query: 426 FDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGG 483
E + N+ LA VF+ + + R++ E +G N+ + + PFGG
Sbjct: 342 VKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGG 401
Query: 484 YKKSGFGRENGRVTIEYYS 502
SG G +G+ + + +S
Sbjct: 402 VGSSGMGAYHGKHSFDTFS 420
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 136 bits (343), Expect = 4e-32
Identities = 100/341 (29%), Positives = 155/341 (45%), Gaps = 19/341 (5%)
Query: 165 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 224
+ R+EP G+ + I WNYP + ALA GN +V KPS + +LAE+ +
Sbjct: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
Query: 225 VPPGLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 283
V F VV GG TGQ L D + FTGS G +M +AK + PVTLELGGK+
Sbjct: 158 VDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAAAKHLTPVTLELGGKN 215
Query: 284 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 343
P + +CD + GQ C V E+ ++ + R GD
Sbjct: 216 PCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YGD 274
Query: 344 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 403
+G +IN+ +R+ + +V GG + Y+ P VL
Sbjct: 275 DPQSSPNLGRIINQKQFQRLRALLGC-----GRVAIGGQ-------SDESDRYIAPTVLV 322
Query: 404 NCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQ 463
+ ++ ++EEIFGP++ I++ + E +E N LA F+ Q RV+ +
Sbjct: 323 DVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTS 382
Query: 464 AGTCFINN--YNVSPVELPFGGYKKSGFGRENGRVTIEYYS 502
+G N+ +++ LPFGG SG GR +G+ + + +S
Sbjct: 383 SGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFS 423
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 136 bits (343), Expect = 4e-32
Identities = 100/341 (29%), Positives = 155/341 (45%), Gaps = 19/341 (5%)
Query: 165 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 224
+ R+EP G+ + I WNYP + ALA GN +V KPS + +LAE+ +
Sbjct: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
Query: 225 VPPGLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 283
V F VV GG TGQ L D + FTGS G +M +AK + PVTLELGGK+
Sbjct: 121 VDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAAAKHLTPVTLELGGKN 178
Query: 284 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 343
P + +CD + GQ C V E+ ++ + R GD
Sbjct: 179 PCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YGD 237
Query: 344 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 403
+G +IN+ +R+ + +V GG + Y+ P VL
Sbjct: 238 DPQSSPNLGRIINQKQFQRLRALLGC-----GRVAIGGQ-------SDESDRYIAPTVLV 285
Query: 404 NCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQ 463
+ ++ ++EEIFGP++ I++ + E +E N LA F+ Q RV+ +
Sbjct: 286 DVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTS 345
Query: 464 AGTCFINN--YNVSPVELPFGGYKKSGFGRENGRVTIEYYS 502
+G N+ +++ LPFGG SG GR +G+ + + +S
Sbjct: 346 SGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFS 386
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 136 bits (343), Expect = 4e-32
Identities = 100/341 (29%), Positives = 155/341 (45%), Gaps = 19/341 (5%)
Query: 165 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 224
+ R+EP G+ + I WNYP + ALA GN +V KPS + +LAE+ +
Sbjct: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
Query: 225 VPPGLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 283
V F VV GG TGQ L D + FTGS G +M +AK + PVTLELGGK+
Sbjct: 158 VDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAAAKHLTPVTLELGGKN 215
Query: 284 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 343
P + +CD + GQ C V E+ ++ + R GD
Sbjct: 216 PCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YGD 274
Query: 344 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 403
+G +IN+ +R+ + +V GG + Y+ P VL
Sbjct: 275 DPQSSPNLGRIINQKQFQRLRALLGC-----GRVAIGGQ-------SDESDRYIAPTVLV 322
Query: 404 NCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQ 463
+ ++ ++EEIFGP++ I++ + E +E N LA F+ Q RV+ +
Sbjct: 323 DVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTS 382
Query: 464 AGTCFINN--YNVSPVELPFGGYKKSGFGRENGRVTIEYYS 502
+G N+ +++ LPFGG SG GR +G+ + + +S
Sbjct: 383 SGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFS 423
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 129 bits (323), Expect = 8e-30
Identities = 96/351 (27%), Positives = 158/351 (45%), Gaps = 19/351 (5%)
Query: 168 REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPP 227
+EP G+ + I WNYP + ALA G+ +V KPS + + +LAE+ + +
Sbjct: 21 KEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY-LDQ 79
Query: 228 GLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLI 286
F VV GG TGQ L D + FTGS G +M + K + PVTLELGGK+P
Sbjct: 80 SCFAVVLGGPQETGQLLEHKLDY--IFFTGSPRVGKIVMTAATKHLTPVTLELGGKNPCY 137
Query: 287 IFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLL 346
+ +CD + GQ C V E+ ++ + R GD
Sbjct: 138 VDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YGDDPQ 196
Query: 347 EDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCR 406
+G +IN+ +R+ + +V GG + Y+ P VL + +
Sbjct: 197 SSPNLGRIINQKQFQRLRALLGC-----GRVAIGGQ-------SNESDRYIAPTVLVDVQ 244
Query: 407 DDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGT 466
+ ++EEIFGP++ I++ + E ++ N LA F+ Q ++++ +G+
Sbjct: 245 ETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGS 304
Query: 467 CFINN--YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVE 515
N +S + +PFGG SG GR +G+ T + +S +T + +E
Sbjct: 305 FGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLE 355
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 129 bits (323), Expect = 8e-30
Identities = 96/351 (27%), Positives = 158/351 (45%), Gaps = 19/351 (5%)
Query: 168 REPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPP 227
+EP G+ + I WNYP + ALA G+ +V KPS + + +LAE+ + +
Sbjct: 21 KEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY-LDQ 79
Query: 228 GLFNVVQGGAA-TGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLI 286
F VV GG TGQ L D + FTGS G +M + K + PVTLELGGK+P
Sbjct: 80 SCFAVVLGGPQETGQLLEHKLDY--IFFTGSPRVGKIVMTAATKHLTPVTLELGGKNPCY 137
Query: 287 IFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLL 346
+ +CD + GQ C V E+ ++ + R GD
Sbjct: 138 VDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRF-YGDDPQ 196
Query: 347 EDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCR 406
+G +IN+ +R+ + +V GG + Y+ P VL + +
Sbjct: 197 SSPNLGRIINQKQFQRLRALLGC-----GRVAIGGQ-------SNESDRYIAPTVLVDVQ 244
Query: 407 DDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGT 466
+ ++EEIFGP++ I++ + E ++ N LA F+ Q ++++ +G+
Sbjct: 245 ETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGS 304
Query: 467 CFINN--YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVE 515
N +S + +PFGG SG GR +G+ T + +S +T + +E
Sbjct: 305 FGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLE 355
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,918,781
Number of Sequences: 37866
Number of extensions: 929791
Number of successful extensions: 1982
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 1828
Number of HSP's gapped (non-prelim): 46
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.