BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|114326550 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 [Homo sapiens] (619 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|114326550 solute carrier family 7 (cationic amino acid transp... 1217 0.0 gi|114326544 solute carrier family 7 (cationic amino acid transp... 1217 0.0 gi|4507047 solute carrier family 7 (cationic amino acid transpor... 724 0.0 gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 677 0.0 gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 664 0.0 gi|110347453 solute carrier family 7 (cationic amino acid transp... 477 e-134 gi|181337167 solute carrier family 7 (cationic amino acid transp... 404 e-112 gi|71979932 solute carrier family 7 (cationic amino acid transpo... 108 1e-23 gi|187423910 solute carrier family 7, member 9 [Homo sapiens] 103 6e-22 gi|7657591 solute carrier family 7, member 9 [Homo sapiens] 103 6e-22 gi|7657683 solute carrier family 7, (cationic amino acid transpo... 98 2e-20 gi|186910308 solute carrier family 7 member 7 [Homo sapiens] 90 5e-18 gi|186910306 solute carrier family 7 member 7 [Homo sapiens] 90 5e-18 gi|186910304 solute carrier family 7 member 7 [Homo sapiens] 90 5e-18 gi|33286428 solute carrier family 7 (cationic amino acid transpo... 87 6e-17 gi|115648063 solute carrier family 7 (cationic amino acid transp... 86 1e-16 gi|115648022 solute carrier family 7 (cationic amino acid transp... 86 1e-16 gi|9790235 solute carrier family 7, member 10 [Homo sapiens] 80 6e-15 gi|71999149 solute carrier family 7, (cationic amino acid transp... 60 5e-09 gi|33286430 solute carrier family 7 (cationic amino acid transpo... 52 1e-06 gi|31881740 solute carrier family 12 (potassium/chloride transpo... 48 2e-05 gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 44 3e-04 gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 39 0.011 gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 39 0.011 gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 39 0.011 gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 39 0.011 gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 39 0.011 gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 38 0.032 gi|198041678 solute carrier family 12 (potassium-chloride transp... 37 0.070 gi|11968148 solute carrier family 12 (potassium-chloride transpo... 37 0.070 >gi|114326550 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 [Homo sapiens] Length = 619 Score = 1217 bits (3149), Expect = 0.0 Identities = 619/619 (100%), Positives = 619/619 (100%) Query: 1 MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60 MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD Sbjct: 1 MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60 Query: 61 KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120 KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS Sbjct: 61 KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120 Query: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA Sbjct: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180 Query: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL Sbjct: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240 Query: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF Sbjct: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300 Query: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI Sbjct: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360 Query: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL Sbjct: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420 Query: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC Sbjct: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480 Query: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK Sbjct: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540 Query: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR Sbjct: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600 Query: 601 KSRAKTVDLDPGTLYVHSV 619 KSRAKTVDLDPGTLYVHSV Sbjct: 601 KSRAKTVDLDPGTLYVHSV 619 >gi|114326544 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 [Homo sapiens] Length = 619 Score = 1217 bits (3149), Expect = 0.0 Identities = 619/619 (100%), Positives = 619/619 (100%) Query: 1 MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60 MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD Sbjct: 1 MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60 Query: 61 KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120 KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS Sbjct: 61 KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120 Query: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA Sbjct: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180 Query: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL Sbjct: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240 Query: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF Sbjct: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300 Query: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI Sbjct: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360 Query: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL Sbjct: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420 Query: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC Sbjct: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480 Query: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK Sbjct: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540 Query: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR Sbjct: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600 Query: 601 KSRAKTVDLDPGTLYVHSV 619 KSRAKTVDLDPGTLYVHSV Sbjct: 601 KSRAKTVDLDPGTLYVHSV 619 >gi|4507047 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 [Homo sapiens] Length = 629 Score = 724 bits (1869), Expect = 0.0 Identities = 378/612 (61%), Positives = 458/612 (74%), Gaps = 41/612 (6%) Query: 10 GQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVIC 69 GQ+++RR+ ++ ETRL+RCL+T DLVALGVGSTLGAGVYVLAG VA++ AGP+IVI Sbjct: 10 GQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVIS 69 Query: 70 FLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVA 129 FL+AAL+SVLAGLCY EFGARVP++GSAYLYSYVTVGELWAF TGWNLILSY+IGT+SVA Sbjct: 70 FLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVA 129 Query: 130 RAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALV 189 RAWS+ FD LIG I + + + L+ P VLAE PD FA+ ++L+LTGLL LG ESA+V Sbjct: 130 RAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMV 189 Query: 190 TKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAEL---NDTYSLGPLGSGGFV 246 K+FT +N+LVLGF+M+SGFVKG V NW+LTEED+ L NDT G G GGF+ Sbjct: 190 NKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKE-GKPGVGGFM 248 Query: 247 PFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSAL 306 PFGF G+L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL +CF+AYF VS+AL Sbjct: 249 PFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAAL 308 Query: 307 TLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAED 366 TLMMPY+ L SPLP+AF ++GW A+Y VAVGSLCALS SLLGSMFPMPRVIYAMAED Sbjct: 309 TLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAED 368 Query: 367 GLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVL 426 GLLF+ LA ++ T+TPIIAT+ SG +AA MAFLF L DLVDLMSIGTLLAYSLV+ CVL Sbjct: 369 GLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVL 428 Query: 427 ILRYQPDQE------TKTGEEVEL--QEEAITT---------ESEKLTLWGLFFPLNSIP 469 +LRYQP+Q T +E++ Q E +T E+E +L + P N P Sbjct: 429 VLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEP 488 Query: 470 TPLSGQIVYVCSSLLAVLLTALCLVL----------AQWSVPLLSGDLLWTAVVVLLLLL 519 + +SG IV + +SL+AVL+ C+V A W+V LL+G L AVV Sbjct: 489 SKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVT----- 543 Query: 520 IIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFA 579 VIWRQP+S T L FKVP LP+LP++SIFVN+YLMMQ+ GTW RF VWMLIGF Sbjct: 544 -----GVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFI 598 Query: 580 IYFGYGIQHSLE 591 IYFGYG+ HS E Sbjct: 599 IYFGYGLWHSEE 610 >gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo sapiens] Length = 658 Score = 677 bits (1747), Expect = 0.0 Identities = 365/611 (59%), Positives = 452/611 (73%), Gaps = 24/611 (3%) Query: 1 MPWQAFRRFGQKLVRRR--TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVA 58 +P +A F + L+RR+ TL+S + +T+L RCLST+DL+ALGVGSTLGAGVYVLAGEVA Sbjct: 2 IPCRAALTFARCLIRRKIVTLDS-LEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 60 Query: 59 KDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLI 118 K +GPSIV+ FL+AAL+SV+AGLCYAEFGARVP++GSAYLY+YVTVGELWAF TGWNLI Sbjct: 61 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 120 Query: 119 LSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGL 178 LSYVIGT+SVARAWS FD L+ I + L+ ++ LAEYPDFFA+ L+LLL GL Sbjct: 121 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 179 Query: 179 LALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYS-- 236 L+ G ESA V KVFT VN+LVL FVM++GFVKG+V NWK++EE + A + S Sbjct: 180 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSEN 239 Query: 237 -LGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVC 295 G+GGF+P+GF G L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL VC Sbjct: 240 GTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVC 299 Query: 296 FLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFP 355 F+AYF VS+ALTLMMPYY L +SPLP AF Y+GW PA+YVVA GSLCALSTSLLGS+FP Sbjct: 300 FMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFP 359 Query: 356 MPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTL 415 MPRVIYAMAEDGLLF+ LA+I++ T+TPIIAT+ SG +AA MAFLF L LVD+MSIGTL Sbjct: 360 MPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTL 419 Query: 416 LAYSLVSICVLILRYQP----DQETKTGEEVEL-QEEAITTESEK---------LTLWGL 461 +AYSLV+ CVLILRYQP DQ + E+ L +T++SE ++ L Sbjct: 420 MAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTL 479 Query: 462 FFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWT-AVVVLLLLLI 520 F P + +PT S +V LA L+ L VL + V ++ W+ A++ L L+L Sbjct: 480 FCP-SLLPTQQSASLVSFLVGFLAFLVLGLS-VLTTYGVHAITRLEAWSLALLALFLVLF 537 Query: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAI 580 + I++ IWR PQ+ + F VP LP LP SI VNIYLM+Q++A TW RF +WM IGF I Sbjct: 538 VAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLI 597 Query: 581 YFGYGIQHSLE 591 YF YGI+HSLE Sbjct: 598 YFSYGIRHSLE 608 >gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo sapiens] Length = 697 Score = 664 bits (1713), Expect = 0.0 Identities = 357/611 (58%), Positives = 449/611 (73%), Gaps = 25/611 (4%) Query: 1 MPWQAFRRFGQKLVRRR--TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVA 58 +P +A F + L+RR+ TL+S + +T+L RCLST+DL+ALGVGSTLGAGVYVLAGEVA Sbjct: 42 IPCRAALTFARCLIRRKIVTLDS-LEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 100 Query: 59 KDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLI 118 K +GPSIV+ FL+AAL+SV+AGLCYAEFGARVP++GSAYLY+YVTVGELWAF TGWNLI Sbjct: 101 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 160 Query: 119 LSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGL 178 LSYVIGT+SVARAWS FD L+ I + L+ ++ LAEYPDFFA+ L+LLL GL Sbjct: 161 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 219 Query: 179 LALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYS-- 236 L+ G ESA V KVFT VN+LVL FVM++GFVKG+V NWK++EE + A + S Sbjct: 220 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSEN 279 Query: 237 -LGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVC 295 G+GGF+P+GF G L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL VC Sbjct: 280 GTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVC 339 Query: 296 FLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFP 355 F+AYF VS+ALTLMMPYY L +SPLP AF Y+GW PA+YVVA GSLCALSTSLLGSMFP Sbjct: 340 FMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFP 399 Query: 356 MPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTL 415 +PR+++AMA DGLLFR LAR+ + ++P+ AT+ +G+I+A MAFLF L LVD+MSIGTL Sbjct: 400 LPRILFAMARDGLLFRFLARV-SKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTL 458 Query: 416 LAYSLVSICVLILRYQP----DQETKTGEEVEL-QEEAITTESEK---------LTLWGL 461 +AYSLV+ CVLILRYQP DQ + E+ L +T++SE ++ L Sbjct: 459 MAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTL 518 Query: 462 FFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWT-AVVVLLLLLI 520 F P + +PT S +V LA L+ L VL + V ++ W+ A++ L L+L Sbjct: 519 FCP-SLLPTQQSASLVSFLVGFLAFLVLGLS-VLTTYGVHAITRLEAWSLALLALFLVLF 576 Query: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAI 580 + I++ IWR PQ+ + F VP LP LP SI VNIYLM+Q++A TW RF +WM IGF I Sbjct: 577 VAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLI 636 Query: 581 YFGYGIQHSLE 591 YF YGI+HSLE Sbjct: 637 YFSYGIRHSLE 647 >gi|110347453 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 [Homo sapiens] Length = 635 Score = 477 bits (1227), Expect = e-134 Identities = 261/613 (42%), Positives = 374/613 (61%), Gaps = 62/613 (10%) Query: 8 RFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIV 67 R QKL R + LE ET L RCLSTLDL LGVG +G+G+YVL G VAK+ AGP+++ Sbjct: 13 RLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVL 72 Query: 68 ICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTAS 127 + F VAA++S+LA LCYAEFGARVPR+GSAYL++YV++GELWAF GWN++L Y+IG A+ Sbjct: 73 LSFGVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAA 132 Query: 128 VARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESA 187 VARAWS D++ + I + + +L YPDF A G++LL + ++ GA S+ Sbjct: 133 VARAWSGYLDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSS 192 Query: 188 LVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVP 247 + F+ ++LLV+ F++I GF+ HNW E GGF P Sbjct: 193 WLNHTFSAISLLVILFIVILGFILAQPHNWSADE---------------------GGFAP 231 Query: 248 FGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALT 307 FGF G++ G A+CFYAFVGFD IA + EEAQNP+RS+P+ I ISL++ AY VS+ LT Sbjct: 232 FGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLT 291 Query: 308 LMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDG 367 LM+P++ L P+S L +AF G+ A ++VA GS+CA++T LL +F +PR++YAMA DG Sbjct: 292 LMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADG 351 Query: 368 LLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLI 427 L F+V A +H T+ P+ T+ G++ AF+A L L LV +S+GTLLAY+ V+ +++ Sbjct: 352 LFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSIIV 411 Query: 428 LRYQ---PDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTP------------- 471 LR+Q P L ++ ++ S+ L L G S+P P Sbjct: 412 LRFQKSSPPSSPGPASPGPLTKQQ-SSFSDHLQLVGTVHA--SVPEPGELKPALRPYLGF 468 Query: 472 LSGQ-----IVYVCSSLLAVLLTALCLV--------LAQWSVPLLSGDLLWTAVVVLLLL 518 L G + + +LA +T C++ L W LL LL T+V+ LL L Sbjct: 469 LDGYSPGAVVTWALGVMLASAITIGCVLVFGNSTLHLPHWGYILL---LLLTSVMFLLSL 525 Query: 519 LIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGF 578 L++G Q Q L F++P +PL+P +SI +NI LM++++ TW RF +W+L+G Sbjct: 526 LVLGA-----HQQQYREDL-FQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIWLLMGL 579 Query: 579 AIYFGYGIQHSLE 591 A+YFGYGI+HS E Sbjct: 580 AVYFGYGIRHSKE 592 >gi|181337167 solute carrier family 7 (cationic amino acid transporter, y+ system), member 14 [Homo sapiens] Length = 771 Score = 404 bits (1038), Expect = e-112 Identities = 217/438 (49%), Positives = 293/438 (66%), Gaps = 31/438 (7%) Query: 26 TRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYA 85 T+LA+ L+T+DL++LGVGS +G G+YV++G VAK+ AGP +++ F++AA++S+L+G+CYA Sbjct: 47 TKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYA 106 Query: 86 EFGARVPRS-GSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHI 144 EFG RVP++ GSAY YSYVTVGE AF GWNLIL Y+IGTA+ A A SS FD+L + I Sbjct: 107 EFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTI 166 Query: 145 SKTLQGSIALHVPHVLAE--YPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLG 202 S+ + S+ E YPD AL + +++T ++ALG S V +NL V Sbjct: 167 SRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWV 226 Query: 203 FVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFY 262 F+MI+G + W G F+P G+ G+L+GAATCFY Sbjct: 227 FIMIAGLFFINGKYW-----------------------AEGQFLPHGWSGVLQGAATCFY 263 Query: 263 AFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLP 322 AF+GFD IATTGEEA+NP SIP I SL +C AY +VS LTLM+PYY + ESPL Sbjct: 264 AFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLM 323 Query: 323 EAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRT 382 E F+ G+ A++VVA+GS+ L+ SLLGS+FPMPRVIYAMA DGLLFR LA + + T T Sbjct: 324 EMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTET 383 Query: 383 PIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETK----- 437 P++A +VSG +AA +A L L DL+++MSIGTLLAY+LVS+CVL+LRYQP+ + Sbjct: 384 PVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKF 443 Query: 438 TGEEVELQEEAITTESEK 455 EE ++E I + EK Sbjct: 444 LSEEHTKKKEGILADCEK 461 Score = 97.1 bits (240), Expect = 4e-20 Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 3/144 (2%) Query: 469 PTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIV-VI 527 PT +G V +C LL +L+ C + S +S W ++V+L++L+I +V VI Sbjct: 557 PTAATGHTVTICVLLLFILMFIFCSFIIFGS-DYISEQSWWAILLVVLMVLLISTLVFVI 615 Query: 528 WRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQ 587 +QP++ L + P LP +P ++ VNIYLM++++ TW RF VW +G IYFGYGI Sbjct: 616 LQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGLLIYFGYGIW 675 Query: 588 HSLEEIKSNQPS-RKSRAKTVDLD 610 +S EI + + + +S + D+D Sbjct: 676 NSTLEISAREEALHQSTYQRYDVD 699 >gi|71979932 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 [Homo sapiens] Length = 507 Score = 108 bits (271), Expect = 1e-23 Identities = 105/411 (25%), Positives = 179/411 (43%), Gaps = 42/411 (10%) Query: 28 LARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSI-VICFLVAALSSVLAGLCYAE 86 L R ++ L+ VA+ VG+ +G+G++V V K+ P + ++ + + S++ LCYAE Sbjct: 46 LQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAE 105 Query: 87 FGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLI-GNHIS 145 G + +SG Y Y G L AF W +L + R S L+ ++ Sbjct: 106 LGTTISKSGGDYAYMLEVYGSLPAFLKLWIELL--------IIRPSSQYIVALVFATYLL 157 Query: 146 KTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVM 205 K L + VP A+ A VLLLT + + V F LL L ++ Sbjct: 158 KPLFPTCP--VPEEAAK---LVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALII 212 Query: 206 ISGFV---KGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFY 262 + GFV KGDV N + N ++ L G V + G+ + Sbjct: 213 LLGFVQIGKGDVSN------------LDPNFSFEGTKLDVGNIVLALYSGL--------F 252 Query: 263 AFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLP 322 A+ G++ + EE NP R++P+ I+ISL + L Y + A + Q+ + Sbjct: 253 AYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVA 312 Query: 323 EAF--LYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGT 380 F ++G V VG C S + GS+F R+ + + +G L +L+ IH Sbjct: 313 VDFGNYHLGVMSWIIPVFVGLSCFGSVN--GSLFTSSRLFFVGSREGHLPSILSMIHPQL 370 Query: 381 RTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431 TP+ + V + ++ AF + +++ S L +L I ++ LR++ Sbjct: 371 LTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHR 421 >gi|187423910 solute carrier family 7, member 9 [Homo sapiens] Length = 487 Score = 103 bits (256), Expect = 6e-22 Identities = 100/468 (21%), Positives = 199/468 (42%), Gaps = 47/468 (10%) Query: 26 TRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAK--DKAGPSIVICFLVAALSSVLAGLC 83 T L + L + +++ VG+ +G+G++V V + GP ++I L++ L LC Sbjct: 24 TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLAT-LGALC 82 Query: 84 YAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNH 143 +AE G + +SG Y Y G + A+ W ++ VI S A S + + Sbjct: 83 FAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLI--VIKPTSFAIICLSFSEYVCAPF 140 Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203 + P ++ + A +L ++ + +L + V +FT L+++ Sbjct: 141 Y-------VGCKPPQIVVKC---LAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAI 190 Query: 204 VMISGFV---KGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATC 260 ++ISG V +G+ N+ + E +L++ ++ + G Sbjct: 191 IIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNG---------------------- 228 Query: 261 FYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESP 320 +A+ G++ + EE +NP R++P+ I+I + + Y ++ + +M +L Sbjct: 229 LWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQA 288 Query: 321 LPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGT 380 + F PA ++V + + + G+ F R+IY +G + +VL+ I Sbjct: 289 VAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRR 348 Query: 381 RTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGE 440 TP A + GIIA + LV+ S L Y L + ++++R+ T + Sbjct: 349 LTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF-------TRK 401 Query: 441 EVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLL 488 E+E + +TL +F L I + + + +Y +L+ LL Sbjct: 402 ELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLL 449 >gi|7657591 solute carrier family 7, member 9 [Homo sapiens] Length = 487 Score = 103 bits (256), Expect = 6e-22 Identities = 100/468 (21%), Positives = 199/468 (42%), Gaps = 47/468 (10%) Query: 26 TRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAK--DKAGPSIVICFLVAALSSVLAGLC 83 T L + L + +++ VG+ +G+G++V V + GP ++I L++ L LC Sbjct: 24 TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLAT-LGALC 82 Query: 84 YAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNH 143 +AE G + +SG Y Y G + A+ W ++ VI S A S + + Sbjct: 83 FAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLI--VIKPTSFAIICLSFSEYVCAPF 140 Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203 + P ++ + A +L ++ + +L + V +FT L+++ Sbjct: 141 Y-------VGCKPPQIVVKC---LAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAI 190 Query: 204 VMISGFV---KGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATC 260 ++ISG V +G+ N+ + E +L++ ++ + G Sbjct: 191 IIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNG---------------------- 228 Query: 261 FYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESP 320 +A+ G++ + EE +NP R++P+ I+I + + Y ++ + +M +L Sbjct: 229 LWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQA 288 Query: 321 LPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGT 380 + F PA ++V + + + G+ F R+IY +G + +VL+ I Sbjct: 289 VAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRR 348 Query: 381 RTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGE 440 TP A + GIIA + LV+ S L Y L + ++++R+ T + Sbjct: 349 LTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF-------TRK 401 Query: 441 EVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLL 488 E+E + +TL +F L I + + + +Y +L+ LL Sbjct: 402 ELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLL 449 >gi|7657683 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 [Homo sapiens] Length = 501 Score = 98.2 bits (243), Expect = 2e-20 Identities = 98/421 (23%), Positives = 182/421 (43%), Gaps = 47/421 (11%) Query: 22 GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD--KAGPSIVICFLVAALSSVL 79 G + +L R ++ L V++ +G+ +GAG+++ V ++ G S+ I + V + S+ Sbjct: 34 GQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTI-WTVCGVLSLF 92 Query: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGW-NLILSYVIGTASVARAWSSAFDN 138 L YAE G + +SG Y Y G L AF W L++ TA ++ A+ Sbjct: 93 GALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAF------ 146 Query: 139 LIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNL 198 G +I + I +P + + + +V++L ++ S SA + T L Sbjct: 147 --GRYILEPF--FIQCEIPELAIKLITAVGITVVMVLN---SMSVSWSARIQIFLTFCKL 199 Query: 199 LVLGFVMISG---FVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILR 255 + +++ G +KG N+K + ++ L + G Sbjct: 200 TAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYG----------------- 242 Query: 256 GAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQL 315 YA+ G+ + EE +NP+++IP+ I IS+++ + Y + A + +L Sbjct: 243 -----MYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEEL 297 Query: 316 QPESPLPEAFLYIGWAPARYVVAVGSLCALST--SLLGSMFPMPRVIYAMAEDGLLFRVL 373 + + A + + +AV ALS S+ G +F + R+ Y + +G L +L Sbjct: 298 LLSNAV--AVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEIL 355 Query: 374 ARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ-P 432 + IH TP+ A +V + M F L L++ +S L L ++ LRY+ P Sbjct: 356 SMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCP 415 Query: 433 D 433 D Sbjct: 416 D 416 >gi|186910308 solute carrier family 7 member 7 [Homo sapiens] Length = 511 Score = 90.1 bits (222), Expect = 5e-18 Identities = 99/427 (23%), Positives = 172/427 (40%), Gaps = 57/427 (13%) Query: 22 GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVL 79 G + +L + +S L+ V L VG+ +G+G++V V A G S+VI + V L SV Sbjct: 27 GPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVF 85 Query: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNL 139 LCYAE G + +SG++Y Y G AF W +L +I S A Sbjct: 86 GALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-----IIAIT 138 Query: 140 IGNHISKTLQGSIALHVPHVLAEY--PDFFALGLVLLLTGLLALGASESALVTKVFTGVN 197 N++ + L P A Y A + LLT + LV +FT Sbjct: 139 FANYMVQPL-------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAK 191 Query: 198 LLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPF--GFEG--- 252 +L L V+++G V+ LG G F FEG Sbjct: 192 VLALIAVIVAGIVR----------------------------LGQGASTHFENSFEGSSF 223 Query: 253 ----ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTL 308 I + +++ G+D + EE +NP+R++P+ I IS+ + + Y + A Sbjct: 224 AVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYT 283 Query: 309 MMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL 368 ++ + + F + +++ + + L S+ R+ + + +G Sbjct: 284 VLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGH 343 Query: 369 LFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLIL 428 L + IH TP+ + + +GI+A + + L++ S L + L L Sbjct: 344 LPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYL 403 Query: 429 RY-QPDQ 434 R+ +PD+ Sbjct: 404 RWKEPDR 410 >gi|186910306 solute carrier family 7 member 7 [Homo sapiens] Length = 511 Score = 90.1 bits (222), Expect = 5e-18 Identities = 99/427 (23%), Positives = 172/427 (40%), Gaps = 57/427 (13%) Query: 22 GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVL 79 G + +L + +S L+ V L VG+ +G+G++V V A G S+VI + V L SV Sbjct: 27 GPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVF 85 Query: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNL 139 LCYAE G + +SG++Y Y G AF W +L +I S A Sbjct: 86 GALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-----IIAIT 138 Query: 140 IGNHISKTLQGSIALHVPHVLAEY--PDFFALGLVLLLTGLLALGASESALVTKVFTGVN 197 N++ + L P A Y A + LLT + LV +FT Sbjct: 139 FANYMVQPL-------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAK 191 Query: 198 LLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPF--GFEG--- 252 +L L V+++G V+ LG G F FEG Sbjct: 192 VLALIAVIVAGIVR----------------------------LGQGASTHFENSFEGSSF 223 Query: 253 ----ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTL 308 I + +++ G+D + EE +NP+R++P+ I IS+ + + Y + A Sbjct: 224 AVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYT 283 Query: 309 MMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL 368 ++ + + F + +++ + + L S+ R+ + + +G Sbjct: 284 VLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGH 343 Query: 369 LFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLIL 428 L + IH TP+ + + +GI+A + + L++ S L + L L Sbjct: 344 LPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYL 403 Query: 429 RY-QPDQ 434 R+ +PD+ Sbjct: 404 RWKEPDR 410 >gi|186910304 solute carrier family 7 member 7 [Homo sapiens] Length = 511 Score = 90.1 bits (222), Expect = 5e-18 Identities = 99/427 (23%), Positives = 172/427 (40%), Gaps = 57/427 (13%) Query: 22 GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVL 79 G + +L + +S L+ V L VG+ +G+G++V V A G S+VI + V L SV Sbjct: 27 GPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVF 85 Query: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNL 139 LCYAE G + +SG++Y Y G AF W +L +I S A Sbjct: 86 GALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-----IIAIT 138 Query: 140 IGNHISKTLQGSIALHVPHVLAEY--PDFFALGLVLLLTGLLALGASESALVTKVFTGVN 197 N++ + L P A Y A + LLT + LV +FT Sbjct: 139 FANYMVQPL-------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAK 191 Query: 198 LLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPF--GFEG--- 252 +L L V+++G V+ LG G F FEG Sbjct: 192 VLALIAVIVAGIVR----------------------------LGQGASTHFENSFEGSSF 223 Query: 253 ----ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTL 308 I + +++ G+D + EE +NP+R++P+ I IS+ + + Y + A Sbjct: 224 AVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYT 283 Query: 309 MMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL 368 ++ + + F + +++ + + L S+ R+ + + +G Sbjct: 284 VLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGH 343 Query: 369 LFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLIL 428 L + IH TP+ + + +GI+A + + L++ S L + L L Sbjct: 344 LPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYL 403 Query: 429 RY-QPDQ 434 R+ +PD+ Sbjct: 404 RWKEPDR 410 >gi|33286428 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 isoform a [Homo sapiens] Length = 535 Score = 86.7 bits (213), Expect = 6e-17 Identities = 111/517 (21%), Positives = 205/517 (39%), Gaps = 83/517 (16%) Query: 21 SGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSI-VICFLVAALSSVL 79 SG L + + + + VG+ +G+G++V V ++ + +I ++V +V+ Sbjct: 29 SGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVV 88 Query: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLIL-SYVIGTASVARAWSSAFDN 138 LCYAE G +P+SG Y Y G L F W +L Y A +A +S Sbjct: 89 GALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFS----- 143 Query: 139 LIGNHISKTLQGSIALHVPHVLAEYPDFFALGL-----VLLLTGLLALGASESALVTKVF 193 N++ + L + +P L L +LLLT + + V +F Sbjct: 144 ---NYVLQPLFPTC----------FPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIF 190 Query: 194 TGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGI 253 T LL L ++I G V ++ + +Y E + + G V F Sbjct: 191 TAGKLLALALIIIMGIV-------QICKGEY--FWLEPKNAFENFQEPDIGLVALAF--- 238 Query: 254 LRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYY 313 L+G+ +A+ G++ + EE +P +++P I IS+ + Y + A M Sbjct: 239 LQGS----FAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQ 294 Query: 314 QLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVL 373 +L + + F +++ + + + GS+F R+ +A A +G L VL Sbjct: 295 ELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVL 354 Query: 374 ARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY-QP 432 A IH TPI A + + I M + L++ + L Y + ++LR+ +P Sbjct: 355 AMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKP 414 Query: 433 DQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALC 492 D IP P+ +++ ++ +L A Sbjct: 415 D----------------------------------IPRPIKINLLF---PIIYLLFWAFL 437 Query: 493 LVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWR 529 LV + WS P++ G + ++L + + + V W+ Sbjct: 438 LVFSLWSEPVVCG----IGLAIMLTGVPVYFLGVYWQ 470 >gi|115648063 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 [Homo sapiens] Length = 515 Score = 85.5 bits (210), Expect = 1e-16 Identities = 92/408 (22%), Positives = 173/408 (42%), Gaps = 36/408 (8%) Query: 27 RLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVLAGLCY 84 +L + +S L+ V+L VG+ +G+G++V V A G S+++ + + L SV+ LCY Sbjct: 40 QLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIV-WAIGGLFSVVGALCY 98 Query: 85 AEFGARVPRSGSAYLYSYVTVGELWAFTTGW-NLILSYVIGTASVARAWSSAFDNLIGNH 143 AE G + +SG++Y Y G AF W +L++ G A +A F N I Sbjct: 99 AELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIA----ITFANYI--- 151 Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203 +Q S P LA A + LLT + V FT ++ L Sbjct: 152 ----IQPSFPSCDPPYLA--CRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIA 205 Query: 204 VMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYA 263 +++ G VK + + ++ +E ++ +G L + + ++ Sbjct: 206 IIVMGLVKLCQGHSEHFQDAFE------GSSWDMGNLSLALY-------------SALFS 246 Query: 264 FVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPE 323 + G+D + EE +NP+R++P+ I IS+ + L Y + A ++ + + Sbjct: 247 YSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAV 306 Query: 324 AFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTP 383 F + + + + + L S+F R+ + + +G L +L+ IH TP Sbjct: 307 TFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTP 366 Query: 384 IIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431 I A + + +A + + L++ S L + L LR++ Sbjct: 367 IPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWK 414 >gi|115648022 solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 [Homo sapiens] Length = 515 Score = 85.5 bits (210), Expect = 1e-16 Identities = 92/408 (22%), Positives = 173/408 (42%), Gaps = 36/408 (8%) Query: 27 RLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVLAGLCY 84 +L + +S L+ V+L VG+ +G+G++V V A G S+++ + + L SV+ LCY Sbjct: 40 QLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIV-WAIGGLFSVVGALCY 98 Query: 85 AEFGARVPRSGSAYLYSYVTVGELWAFTTGW-NLILSYVIGTASVARAWSSAFDNLIGNH 143 AE G + +SG++Y Y G AF W +L++ G A +A F N I Sbjct: 99 AELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIA----ITFANYI--- 151 Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203 +Q S P LA A + LLT + V FT ++ L Sbjct: 152 ----IQPSFPSCDPPYLA--CRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIA 205 Query: 204 VMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYA 263 +++ G VK + + ++ +E ++ +G L + + ++ Sbjct: 206 IIVMGLVKLCQGHSEHFQDAFE------GSSWDMGNLSLALY-------------SALFS 246 Query: 264 FVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPE 323 + G+D + EE +NP+R++P+ I IS+ + L Y + A ++ + + Sbjct: 247 YSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAV 306 Query: 324 AFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTP 383 F + + + + + L S+F R+ + + +G L +L+ IH TP Sbjct: 307 TFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTP 366 Query: 384 IIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431 I A + + +A + + L++ S L + L LR++ Sbjct: 367 IPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWK 414 >gi|9790235 solute carrier family 7, member 10 [Homo sapiens] Length = 523 Score = 80.1 bits (196), Expect = 6e-15 Identities = 94/420 (22%), Positives = 178/420 (42%), Gaps = 39/420 (9%) Query: 18 TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVI-CFLVAALS 76 T+ L + + L + +G+ +G+G+++ V + + + +++ Sbjct: 26 TVPGASERVALKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGV 85 Query: 77 SVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAF 136 + L LCYAE G +P+SG Y Y G L F W+ +L ++ S+A S F Sbjct: 86 TALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVL--IMYPTSLA-VISMTF 142 Query: 137 DNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGV 196 N + LQ +P A ++ ++LLT + + + + +FTG Sbjct: 143 SNYV-------LQPVFPNCIPPTTAS--RVLSMACLMLLTWVNSSSVRWATRIQDMFTGG 193 Query: 197 NLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRG 256 LL L ++ G + ++ + +E ++ ++ S G + F L+G Sbjct: 194 KLLALSLIIGVGLL-------QIFQGHFE--ELRPSNAFAFWMTPSVGHLALAF---LQG 241 Query: 257 AATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLS-VCFLAYFAVSSALTLMMPYYQL 315 + +AF G++ + EE + ++++P I IS+ V F+ F + T M P L Sbjct: 242 S----FAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELL 297 Query: 316 QPES---PLPEAFL-YIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFR 371 + E L Y W V+ V + + G +F R+ ++ A +G L Sbjct: 298 SSNAVAVTFGEKLLGYFSW-----VMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPS 352 Query: 372 VLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431 +LA IH TPI A +V A + + L++ +S L Y + + +L+LR++ Sbjct: 353 LLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWR 412 >gi|71999149 solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 [Homo sapiens] Length = 470 Score = 60.5 bits (145), Expect = 5e-09 Identities = 94/399 (23%), Positives = 168/399 (42%), Gaps = 54/399 (13%) Query: 46 LGAGVYVLA-GEVAKDKAGPSIVICFLVA-ALSSVLAGLCYAEFGARVPRSGSAYLYSYV 103 +GAG++V G +A + +C A+ ++ + LC AE P SG+ Y + Sbjct: 27 IGAGIFVSPKGVLAYSCMNVGVSLCVWAGCAILAMTSTLCSAEISISFPCSGAQYYFLKR 86 Query: 104 TVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEY 163 G AF W S +G+ VA A L+ + + S + VP + + Sbjct: 87 YFGSTVAFLNLWT---SLFLGSGVVA---GQAL--LLAEYSIQPFFPSCS--VPKLPKK- 135 Query: 164 PDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVMISG---FVKGDVHNWKLT 220 AL ++ ++ L + G E + + + + +L F+ ++G ++G N + Sbjct: 136 --CLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVERF 193 Query: 221 EEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNP 280 + ++ AEL D L + I +G ++A+ G C E + P Sbjct: 194 QNAFD---AELPDISHL------------IQAIFQG----YFAYSGGACFTLIAGELKKP 234 Query: 281 QRSIPMGIVISLSVCFLAYFAVS-SALTLMMPYYQLQPESP----LPEAFLYIGWAPARY 335 + +IP I +L + + Y V+ S LT++ P L ++ AF + W Sbjct: 235 RTTIPKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDAVAITWADRAFPSLAW----- 289 Query: 336 VVAVGSLCALSTSLLGSMFPMPRVIYAMAEDG---LLFRVLARIHTGTRTPIIATVVSGI 392 ++ +L ++LL S+F R IY +++G LLF L H+ T ++ V G Sbjct: 290 IMPFAISTSLFSNLLISIFKSSRPIYLASQEGQLPLLFNTL-NSHSSPFTAVLLLVTLGS 348 Query: 393 IAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431 +A L L DL++ + L L+ I +L RYQ Sbjct: 349 LA---IILTSLIDLINYIFFTGSLWSILLMIGILRRRYQ 384 Score = 31.2 bits (69), Expect = 3.0 Identities = 29/100 (29%), Positives = 54/100 (54%), Gaps = 14/100 (14%) Query: 461 LFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLI 520 LF LNS +P + ++ V LA++LT+L ++ + +G LW+ +LL+ Sbjct: 326 LFNTLNSHSSPFTAVLLLVTLGSLAIILTSLIDLI---NYIFFTGS-LWS------ILLM 375 Query: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMM 560 IGI+ +++P S P +KV PL +I +++ L++ Sbjct: 376 IGILRRRYQEPNLSIP--YKV--FLSFPLATIVIDVGLVV 411 >gi|33286430 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 isoform b [Homo sapiens] Length = 332 Score = 52.4 bits (124), Expect = 1e-06 Identities = 54/269 (20%), Positives = 107/269 (39%), Gaps = 42/269 (15%) Query: 262 YAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPL 321 +A+ G++ + EE +P +++P I IS+ + Y + A M +L + + Sbjct: 40 FAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAV 99 Query: 322 PEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTR 381 F +++ + + + GS+F R+ +A A +G L VLA IH Sbjct: 100 AVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRC 159 Query: 382 TPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY-QPDQETKTGE 440 TPI A + + I M + L++ + L Y + ++LR+ +PD Sbjct: 160 TPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPD------- 212 Query: 441 EVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSV 500 IP P+ +++ ++ +L A LV + WS Sbjct: 213 ---------------------------IPRPIKINLLF---PIIYLLFWAFLLVFSLWSE 242 Query: 501 PLLSGDLLWTAVVVLLLLLIIGIIVVIWR 529 P++ G + ++L + + + V W+ Sbjct: 243 PVVCG----IGLAIMLTGVPVYFLGVYWQ 267 >gi|31881740 solute carrier family 12 (potassium/chloride transporters), member 9 [Homo sapiens] Length = 914 Score = 48.1 bits (113), Expect = 2e-05 Identities = 40/175 (22%), Positives = 75/175 (42%), Gaps = 7/175 (4%) Query: 258 ATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQP 317 A F G A E ++P R+IP+G +++++ F Y + + LQ Sbjct: 272 AVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQE 331 Query: 318 ESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIH 377 + A W P +V +G ++ + S+ R+++A+A D L +LA Sbjct: 332 DYGFFRAISL--WPP---LVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAK 386 Query: 378 TGTR--TPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY 430 +R P A + S + + KL L ++++ L+AY+ V + L L + Sbjct: 387 VVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEW 441 >gi|38569457 solute carrier family 12, member 8 [Homo sapiens] Length = 714 Score = 44.3 bits (103), Expect = 3e-04 Identities = 82/389 (21%), Positives = 156/389 (40%), Gaps = 47/389 (12%) Query: 63 GPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYV 122 G +V ++ AL +VL+G+ E + GS +YS ++ + TG + L YV Sbjct: 74 GMFLVSFVILVALVTVLSGIGVGERSS----IGSGGVYSMIS--SVLGGQTGGTIGLLYV 127 Query: 123 IGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALG 182 G + + F I + L + +A+ + + L LG Sbjct: 128 FGQCVAGAMYITGFAESISD-----------------LLGLGNIWAVRGISVAVLLALLG 170 Query: 183 ASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGS 242 + + + + + LL L V FV G + E + EL +L P S Sbjct: 171 INLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLD-PEHGFIGYSPELLQNNTL-PDYS 228 Query: 243 GGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAV 302 G F G+ AAT A GF+ G + + P SIP+G + ++ + + Y Sbjct: 229 PGESFFTVFGVFFPAATGVMA--GFNM----GGDLREPAASIPLGSLAAVGISWFLYIVF 282 Query: 303 SSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYA 362 L + L+ + + E +G ++ +G + S +G ++ PR++ Sbjct: 283 VFLLGAICTREALRYDFLIAEKVSLMG-----FLFLLGLYISSLASCMGGLYGAPRILQC 337 Query: 363 MAEDGLLFRVLARIHTG---TRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYS 419 +A++ ++ LA + G +TP+ A ++ ++ F+ ++ L +++I +L Y Sbjct: 338 IAQEKVI-PALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYV 396 Query: 420 LV-------SICVLILRYQPDQETKTGEE 441 V S+C L P+ + G E Sbjct: 397 AVDYSYFSLSMCSCSLTPVPEPVLREGAE 425 >gi|225579067 solute carrier family 12, member 4 isoform e [Homo sapiens] Length = 1054 Score = 39.3 bits (90), Expect = 0.011 Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%) Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304 ++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+ Sbjct: 381 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 440 Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360 + L+ + L +G W P+ +V+ +GS + + L S+ PR++ Sbjct: 441 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 499 Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418 A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y Sbjct: 500 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 558 Query: 419 SLVSICVLI 427 V++ + Sbjct: 559 LFVNLACAV 567 >gi|225579065 solute carrier family 12, member 4 isoform d [Homo sapiens] Length = 1079 Score = 39.3 bits (90), Expect = 0.011 Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%) Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304 ++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+ Sbjct: 406 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 465 Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360 + L+ + L +G W P+ +V+ +GS + + L S+ PR++ Sbjct: 466 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 524 Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418 A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y Sbjct: 525 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 583 Query: 419 SLVSICVLI 427 V++ + Sbjct: 584 LFVNLACAV 592 >gi|225579063 solute carrier family 12, member 4 isoform c [Homo sapiens] Length = 1087 Score = 39.3 bits (90), Expect = 0.011 Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%) Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304 ++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+ Sbjct: 414 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 473 Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360 + L+ + L +G W P+ +V+ +GS + + L S+ PR++ Sbjct: 474 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 532 Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418 A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y Sbjct: 533 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 591 Query: 419 SLVSICVLI 427 V++ + Sbjct: 592 LFVNLACAV 600 >gi|225579061 solute carrier family 12, member 4 isoform b [Homo sapiens] Length = 1079 Score = 39.3 bits (90), Expect = 0.011 Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%) Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304 ++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+ Sbjct: 412 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 471 Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360 + L+ + L +G W P+ +V+ +GS + + L S+ PR++ Sbjct: 472 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 530 Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418 A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y Sbjct: 531 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 589 Query: 419 SLVSICVLI 427 V++ + Sbjct: 590 LFVNLACAV 598 >gi|4827006 solute carrier family 12, member 4 isoform a [Homo sapiens] Length = 1085 Score = 39.3 bits (90), Expect = 0.011 Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%) Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304 ++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+ Sbjct: 412 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 471 Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360 + L+ + L +G W P+ +V+ +GS + + L S+ PR++ Sbjct: 472 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 530 Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418 A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y Sbjct: 531 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 589 Query: 419 SLVSICVLI 427 V++ + Sbjct: 590 LFVNLACAV 598 >gi|134254459 sodium potassium chloride cotransporter 2 [Homo sapiens] Length = 1099 Score = 37.7 bits (86), Expect = 0.032 Identities = 56/288 (19%), Positives = 114/288 (39%), Gaps = 51/288 (17%) Query: 175 LTGLLALGASESALVTKVFTGVNLLVLGFVMISGFVKGDV---HNWKLTEEDYELAMAEL 231 +T ++ LG S + + + V LLV+ + I+ F G V +N K + + + Sbjct: 307 ITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIF 366 Query: 232 NDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVIS 291 + + GP + G EG A F A G A + ++PQ +IP G +++ Sbjct: 367 AENF--GPRFTKG------EGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLA 418 Query: 292 LSVCFLAYFAV----------------------------SSALTLMMPYYQLQPE----- 318 + + +AY V S+A L + + + E Sbjct: 419 IFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYG 478 Query: 319 --SPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL--LFRVLA 374 + + G+ P ++ G A +S L S+ P+V A+ +D + + A Sbjct: 479 LMNNFQVMSMVSGFGP---LITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA 535 Query: 375 RIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVS 422 + + P+ +++ +IA + +L + ++S L +Y+L++ Sbjct: 536 KGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALIN 583 >gi|198041678 solute carrier family 12 (potassium-chloride transporter), member 5 isoform 1 [Homo sapiens] Length = 1139 Score = 36.6 bits (83), Expect = 0.070 Identities = 56/270 (20%), Positives = 112/270 (41%), Gaps = 25/270 (9%) Query: 175 LTGLLALGASESALVTKVFTGVNLLVLGFV--MISGFVKGDVHNWKLTEEDYELAMAELN 232 L GL +A + FT N+ + + SG +K ++ + LT+ + E + Sbjct: 340 LWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKG----VIVERS 395 Query: 233 DTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSI 284 S+G L G + + + F VG + TG A ++ Q+SI Sbjct: 396 GMTSVG-LADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSI 454 Query: 285 PMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAF---LYIG---WAPARYVVA 338 P G +++++ Y +SS + + EA L +G W P+ +V+ Sbjct: 455 PTGTILAIATTSAVY--ISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAW-PSPWVIV 511 Query: 339 VGSLCALSTSLLGSMFPMPRVIYAMAEDGLL-FRVLARIHTGTRTPIIATVVSGIIAAFM 397 +GS + + L S+ PR++ A++ DG++ F + P A +++ I Sbjct: 512 IGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIG 571 Query: 398 AFLFKLTDLVDLMSIGTLLAYSLVSICVLI 427 + L ++ ++S+ L+ Y V++ + Sbjct: 572 ILIASLDEVAPILSMFFLMCYMFVNLACAV 601 >gi|11968148 solute carrier family 12 (potassium-chloride transporter), member 5 isoform 2 [Homo sapiens] Length = 1116 Score = 36.6 bits (83), Expect = 0.070 Identities = 56/270 (20%), Positives = 112/270 (41%), Gaps = 25/270 (9%) Query: 175 LTGLLALGASESALVTKVFTGVNLLVLGFV--MISGFVKGDVHNWKLTEEDYELAMAELN 232 L GL +A + FT N+ + + SG +K ++ + LT+ + E + Sbjct: 317 LWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKG----VIVERS 372 Query: 233 DTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSI 284 S+G L G + + + F VG + TG A ++ Q+SI Sbjct: 373 GMTSVG-LADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSI 431 Query: 285 PMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAF---LYIG---WAPARYVVA 338 P G +++++ Y +SS + + EA L +G W P+ +V+ Sbjct: 432 PTGTILAIATTSAVY--ISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAW-PSPWVIV 488 Query: 339 VGSLCALSTSLLGSMFPMPRVIYAMAEDGLL-FRVLARIHTGTRTPIIATVVSGIIAAFM 397 +GS + + L S+ PR++ A++ DG++ F + P A +++ I Sbjct: 489 IGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIG 548 Query: 398 AFLFKLTDLVDLMSIGTLLAYSLVSICVLI 427 + L ++ ++S+ L+ Y V++ + Sbjct: 549 ILIASLDEVAPILSMFFLMCYMFVNLACAV 578 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.325 0.140 0.423 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 21,824,446 Number of Sequences: 37866 Number of extensions: 934559 Number of successful extensions: 3410 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 19 Number of HSP's successfully gapped in prelim test: 31 Number of HSP's that attempted gapping in prelim test: 3307 Number of HSP's gapped (non-prelim): 65 length of query: 619 length of database: 18,247,518 effective HSP length: 108 effective length of query: 511 effective length of database: 14,157,990 effective search space: 7234732890 effective search space used: 7234732890 T: 11 A: 40 X1: 15 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.