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Search of human proteins with 114326544
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
(619 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|114326550 solute carrier family 7 (cationic amino acid transp... 1217 0.0
gi|114326544 solute carrier family 7 (cationic amino acid transp... 1217 0.0
gi|4507047 solute carrier family 7 (cationic amino acid transpor... 724 0.0
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 677 0.0
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 664 0.0
gi|110347453 solute carrier family 7 (cationic amino acid transp... 477 e-134
gi|181337167 solute carrier family 7 (cationic amino acid transp... 404 e-112
gi|71979932 solute carrier family 7 (cationic amino acid transpo... 108 1e-23
gi|187423910 solute carrier family 7, member 9 [Homo sapiens] 103 6e-22
gi|7657591 solute carrier family 7, member 9 [Homo sapiens] 103 6e-22
gi|7657683 solute carrier family 7, (cationic amino acid transpo... 98 2e-20
gi|186910308 solute carrier family 7 member 7 [Homo sapiens] 90 5e-18
gi|186910306 solute carrier family 7 member 7 [Homo sapiens] 90 5e-18
gi|186910304 solute carrier family 7 member 7 [Homo sapiens] 90 5e-18
gi|33286428 solute carrier family 7 (cationic amino acid transpo... 87 6e-17
gi|115648063 solute carrier family 7 (cationic amino acid transp... 86 1e-16
gi|115648022 solute carrier family 7 (cationic amino acid transp... 86 1e-16
gi|9790235 solute carrier family 7, member 10 [Homo sapiens] 80 6e-15
gi|71999149 solute carrier family 7, (cationic amino acid transp... 60 5e-09
gi|33286430 solute carrier family 7 (cationic amino acid transpo... 52 1e-06
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 48 2e-05
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 44 3e-04
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ... 39 0.011
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ... 39 0.011
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ... 39 0.011
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ... 39 0.011
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa... 39 0.011
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 38 0.032
gi|198041678 solute carrier family 12 (potassium-chloride transp... 37 0.070
gi|11968148 solute carrier family 12 (potassium-chloride transpo... 37 0.070
>gi|114326550 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 1217 bits (3149), Expect = 0.0
Identities = 619/619 (100%), Positives = 619/619 (100%)
Query: 1 MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60
MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD
Sbjct: 1 MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60
Query: 61 KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120
KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS
Sbjct: 61 KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120
Query: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180
YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA
Sbjct: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180
Query: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240
LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL
Sbjct: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240
Query: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300
GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF
Sbjct: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300
Query: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI
Sbjct: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
Query: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420
YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL
Sbjct: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420
Query: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480
VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC
Sbjct: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480
Query: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540
SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK
Sbjct: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540
Query: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600
VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR
Sbjct: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600
Query: 601 KSRAKTVDLDPGTLYVHSV 619
KSRAKTVDLDPGTLYVHSV
Sbjct: 601 KSRAKTVDLDPGTLYVHSV 619
>gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 1217 bits (3149), Expect = 0.0
Identities = 619/619 (100%), Positives = 619/619 (100%)
Query: 1 MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60
MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD
Sbjct: 1 MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60
Query: 61 KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120
KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS
Sbjct: 61 KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120
Query: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180
YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA
Sbjct: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180
Query: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240
LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL
Sbjct: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240
Query: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300
GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF
Sbjct: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300
Query: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI
Sbjct: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
Query: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420
YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL
Sbjct: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420
Query: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480
VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC
Sbjct: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480
Query: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540
SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK
Sbjct: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540
Query: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600
VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR
Sbjct: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600
Query: 601 KSRAKTVDLDPGTLYVHSV 619
KSRAKTVDLDPGTLYVHSV
Sbjct: 601 KSRAKTVDLDPGTLYVHSV 619
>gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
Length = 629
Score = 724 bits (1869), Expect = 0.0
Identities = 378/612 (61%), Positives = 458/612 (74%), Gaps = 41/612 (6%)
Query: 10 GQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVIC 69
GQ+++RR+ ++ ETRL+RCL+T DLVALGVGSTLGAGVYVLAG VA++ AGP+IVI
Sbjct: 10 GQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVIS 69
Query: 70 FLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVA 129
FL+AAL+SVLAGLCY EFGARVP++GSAYLYSYVTVGELWAF TGWNLILSY+IGT+SVA
Sbjct: 70 FLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVA 129
Query: 130 RAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALV 189
RAWS+ FD LIG I + + + L+ P VLAE PD FA+ ++L+LTGLL LG ESA+V
Sbjct: 130 RAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMV 189
Query: 190 TKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAEL---NDTYSLGPLGSGGFV 246
K+FT +N+LVLGF+M+SGFVKG V NW+LTEED+ L NDT G G GGF+
Sbjct: 190 NKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKE-GKPGVGGFM 248
Query: 247 PFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSAL 306
PFGF G+L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL +CF+AYF VS+AL
Sbjct: 249 PFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAAL 308
Query: 307 TLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAED 366
TLMMPY+ L SPLP+AF ++GW A+Y VAVGSLCALS SLLGSMFPMPRVIYAMAED
Sbjct: 309 TLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAED 368
Query: 367 GLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVL 426
GLLF+ LA ++ T+TPIIAT+ SG +AA MAFLF L DLVDLMSIGTLLAYSLV+ CVL
Sbjct: 369 GLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVL 428
Query: 427 ILRYQPDQE------TKTGEEVEL--QEEAITT---------ESEKLTLWGLFFPLNSIP 469
+LRYQP+Q T +E++ Q E +T E+E +L + P N P
Sbjct: 429 VLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEP 488
Query: 470 TPLSGQIVYVCSSLLAVLLTALCLVL----------AQWSVPLLSGDLLWTAVVVLLLLL 519
+ +SG IV + +SL+AVL+ C+V A W+V LL+G L AVV
Sbjct: 489 SKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVT----- 543
Query: 520 IIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFA 579
VIWRQP+S T L FKVP LP+LP++SIFVN+YLMMQ+ GTW RF VWMLIGF
Sbjct: 544 -----GVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFI 598
Query: 580 IYFGYGIQHSLE 591
IYFGYG+ HS E
Sbjct: 599 IYFGYGLWHSEE 610
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 677 bits (1747), Expect = 0.0
Identities = 365/611 (59%), Positives = 452/611 (73%), Gaps = 24/611 (3%)
Query: 1 MPWQAFRRFGQKLVRRR--TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVA 58
+P +A F + L+RR+ TL+S + +T+L RCLST+DL+ALGVGSTLGAGVYVLAGEVA
Sbjct: 2 IPCRAALTFARCLIRRKIVTLDS-LEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 60
Query: 59 KDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLI 118
K +GPSIV+ FL+AAL+SV+AGLCYAEFGARVP++GSAYLY+YVTVGELWAF TGWNLI
Sbjct: 61 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 120
Query: 119 LSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGL 178
LSYVIGT+SVARAWS FD L+ I + L+ ++ LAEYPDFFA+ L+LLL GL
Sbjct: 121 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 179
Query: 179 LALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYS-- 236
L+ G ESA V KVFT VN+LVL FVM++GFVKG+V NWK++EE + A + S
Sbjct: 180 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSEN 239
Query: 237 -LGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVC 295
G+GGF+P+GF G L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL VC
Sbjct: 240 GTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVC 299
Query: 296 FLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFP 355
F+AYF VS+ALTLMMPYY L +SPLP AF Y+GW PA+YVVA GSLCALSTSLLGS+FP
Sbjct: 300 FMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFP 359
Query: 356 MPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTL 415
MPRVIYAMAEDGLLF+ LA+I++ T+TPIIAT+ SG +AA MAFLF L LVD+MSIGTL
Sbjct: 360 MPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTL 419
Query: 416 LAYSLVSICVLILRYQP----DQETKTGEEVEL-QEEAITTESEK---------LTLWGL 461
+AYSLV+ CVLILRYQP DQ + E+ L +T++SE ++ L
Sbjct: 420 MAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTL 479
Query: 462 FFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWT-AVVVLLLLLI 520
F P + +PT S +V LA L+ L VL + V ++ W+ A++ L L+L
Sbjct: 480 FCP-SLLPTQQSASLVSFLVGFLAFLVLGLS-VLTTYGVHAITRLEAWSLALLALFLVLF 537
Query: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAI 580
+ I++ IWR PQ+ + F VP LP LP SI VNIYLM+Q++A TW RF +WM IGF I
Sbjct: 538 VAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLI 597
Query: 581 YFGYGIQHSLE 591
YF YGI+HSLE
Sbjct: 598 YFSYGIRHSLE 608
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 664 bits (1713), Expect = 0.0
Identities = 357/611 (58%), Positives = 449/611 (73%), Gaps = 25/611 (4%)
Query: 1 MPWQAFRRFGQKLVRRR--TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVA 58
+P +A F + L+RR+ TL+S + +T+L RCLST+DL+ALGVGSTLGAGVYVLAGEVA
Sbjct: 42 IPCRAALTFARCLIRRKIVTLDS-LEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 100
Query: 59 KDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLI 118
K +GPSIV+ FL+AAL+SV+AGLCYAEFGARVP++GSAYLY+YVTVGELWAF TGWNLI
Sbjct: 101 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 160
Query: 119 LSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGL 178
LSYVIGT+SVARAWS FD L+ I + L+ ++ LAEYPDFFA+ L+LLL GL
Sbjct: 161 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 219
Query: 179 LALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYS-- 236
L+ G ESA V KVFT VN+LVL FVM++GFVKG+V NWK++EE + A + S
Sbjct: 220 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSEN 279
Query: 237 -LGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVC 295
G+GGF+P+GF G L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL VC
Sbjct: 280 GTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVC 339
Query: 296 FLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFP 355
F+AYF VS+ALTLMMPYY L +SPLP AF Y+GW PA+YVVA GSLCALSTSLLGSMFP
Sbjct: 340 FMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFP 399
Query: 356 MPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTL 415
+PR+++AMA DGLLFR LAR+ + ++P+ AT+ +G+I+A MAFLF L LVD+MSIGTL
Sbjct: 400 LPRILFAMARDGLLFRFLARV-SKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTL 458
Query: 416 LAYSLVSICVLILRYQP----DQETKTGEEVEL-QEEAITTESEK---------LTLWGL 461
+AYSLV+ CVLILRYQP DQ + E+ L +T++SE ++ L
Sbjct: 459 MAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTL 518
Query: 462 FFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWT-AVVVLLLLLI 520
F P + +PT S +V LA L+ L VL + V ++ W+ A++ L L+L
Sbjct: 519 FCP-SLLPTQQSASLVSFLVGFLAFLVLGLS-VLTTYGVHAITRLEAWSLALLALFLVLF 576
Query: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAI 580
+ I++ IWR PQ+ + F VP LP LP SI VNIYLM+Q++A TW RF +WM IGF I
Sbjct: 577 VAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLI 636
Query: 581 YFGYGIQHSLE 591
YF YGI+HSLE
Sbjct: 637 YFSYGIRHSLE 647
>gi|110347453 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 4 [Homo sapiens]
Length = 635
Score = 477 bits (1227), Expect = e-134
Identities = 261/613 (42%), Positives = 374/613 (61%), Gaps = 62/613 (10%)
Query: 8 RFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIV 67
R QKL R + LE ET L RCLSTLDL LGVG +G+G+YVL G VAK+ AGP+++
Sbjct: 13 RLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVL 72
Query: 68 ICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTAS 127
+ F VAA++S+LA LCYAEFGARVPR+GSAYL++YV++GELWAF GWN++L Y+IG A+
Sbjct: 73 LSFGVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAA 132
Query: 128 VARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESA 187
VARAWS D++ + I + + +L YPDF A G++LL + ++ GA S+
Sbjct: 133 VARAWSGYLDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSS 192
Query: 188 LVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVP 247
+ F+ ++LLV+ F++I GF+ HNW E GGF P
Sbjct: 193 WLNHTFSAISLLVILFIVILGFILAQPHNWSADE---------------------GGFAP 231
Query: 248 FGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALT 307
FGF G++ G A+CFYAFVGFD IA + EEAQNP+RS+P+ I ISL++ AY VS+ LT
Sbjct: 232 FGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLT 291
Query: 308 LMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDG 367
LM+P++ L P+S L +AF G+ A ++VA GS+CA++T LL +F +PR++YAMA DG
Sbjct: 292 LMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADG 351
Query: 368 LLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLI 427
L F+V A +H T+ P+ T+ G++ AF+A L L LV +S+GTLLAY+ V+ +++
Sbjct: 352 LFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSIIV 411
Query: 428 LRYQ---PDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTP------------- 471
LR+Q P L ++ ++ S+ L L G S+P P
Sbjct: 412 LRFQKSSPPSSPGPASPGPLTKQQ-SSFSDHLQLVGTVHA--SVPEPGELKPALRPYLGF 468
Query: 472 LSGQ-----IVYVCSSLLAVLLTALCLV--------LAQWSVPLLSGDLLWTAVVVLLLL 518
L G + + +LA +T C++ L W LL LL T+V+ LL L
Sbjct: 469 LDGYSPGAVVTWALGVMLASAITIGCVLVFGNSTLHLPHWGYILL---LLLTSVMFLLSL 525
Query: 519 LIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGF 578
L++G Q Q L F++P +PL+P +SI +NI LM++++ TW RF +W+L+G
Sbjct: 526 LVLGA-----HQQQYREDL-FQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIWLLMGL 579
Query: 579 AIYFGYGIQHSLE 591
A+YFGYGI+HS E
Sbjct: 580 AVYFGYGIRHSKE 592
>gi|181337167 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 14 [Homo sapiens]
Length = 771
Score = 404 bits (1038), Expect = e-112
Identities = 217/438 (49%), Positives = 293/438 (66%), Gaps = 31/438 (7%)
Query: 26 TRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYA 85
T+LA+ L+T+DL++LGVGS +G G+YV++G VAK+ AGP +++ F++AA++S+L+G+CYA
Sbjct: 47 TKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYA 106
Query: 86 EFGARVPRS-GSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHI 144
EFG RVP++ GSAY YSYVTVGE AF GWNLIL Y+IGTA+ A A SS FD+L + I
Sbjct: 107 EFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTI 166
Query: 145 SKTLQGSIALHVPHVLAE--YPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLG 202
S+ + S+ E YPD AL + +++T ++ALG S V +NL V
Sbjct: 167 SRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWV 226
Query: 203 FVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFY 262
F+MI+G + W G F+P G+ G+L+GAATCFY
Sbjct: 227 FIMIAGLFFINGKYW-----------------------AEGQFLPHGWSGVLQGAATCFY 263
Query: 263 AFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLP 322
AF+GFD IATTGEEA+NP SIP I SL +C AY +VS LTLM+PYY + ESPL
Sbjct: 264 AFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLM 323
Query: 323 EAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRT 382
E F+ G+ A++VVA+GS+ L+ SLLGS+FPMPRVIYAMA DGLLFR LA + + T T
Sbjct: 324 EMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTET 383
Query: 383 PIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETK----- 437
P++A +VSG +AA +A L L DL+++MSIGTLLAY+LVS+CVL+LRYQP+ +
Sbjct: 384 PVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKF 443
Query: 438 TGEEVELQEEAITTESEK 455
EE ++E I + EK
Sbjct: 444 LSEEHTKKKEGILADCEK 461
Score = 97.1 bits (240), Expect = 4e-20
Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 3/144 (2%)
Query: 469 PTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIV-VI 527
PT +G V +C LL +L+ C + S +S W ++V+L++L+I +V VI
Sbjct: 557 PTAATGHTVTICVLLLFILMFIFCSFIIFGS-DYISEQSWWAILLVVLMVLLISTLVFVI 615
Query: 528 WRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQ 587
+QP++ L + P LP +P ++ VNIYLM++++ TW RF VW +G IYFGYGI
Sbjct: 616 LQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGLLIYFGYGIW 675
Query: 588 HSLEEIKSNQPS-RKSRAKTVDLD 610
+S EI + + + +S + D+D
Sbjct: 676 NSTLEISAREEALHQSTYQRYDVD 699
>gi|71979932 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 5 [Homo sapiens]
Length = 507
Score = 108 bits (271), Expect = 1e-23
Identities = 105/411 (25%), Positives = 179/411 (43%), Gaps = 42/411 (10%)
Query: 28 LARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSI-VICFLVAALSSVLAGLCYAE 86
L R ++ L+ VA+ VG+ +G+G++V V K+ P + ++ + + S++ LCYAE
Sbjct: 46 LQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAE 105
Query: 87 FGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLI-GNHIS 145
G + +SG Y Y G L AF W +L + R S L+ ++
Sbjct: 106 LGTTISKSGGDYAYMLEVYGSLPAFLKLWIELL--------IIRPSSQYIVALVFATYLL 157
Query: 146 KTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVM 205
K L + VP A+ A VLLLT + + V F LL L ++
Sbjct: 158 KPLFPTCP--VPEEAAK---LVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALII 212
Query: 206 ISGFV---KGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFY 262
+ GFV KGDV N + N ++ L G V + G+ +
Sbjct: 213 LLGFVQIGKGDVSN------------LDPNFSFEGTKLDVGNIVLALYSGL--------F 252
Query: 263 AFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLP 322
A+ G++ + EE NP R++P+ I+ISL + L Y + A + Q+ +
Sbjct: 253 AYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVA 312
Query: 323 EAF--LYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGT 380
F ++G V VG C S + GS+F R+ + + +G L +L+ IH
Sbjct: 313 VDFGNYHLGVMSWIIPVFVGLSCFGSVN--GSLFTSSRLFFVGSREGHLPSILSMIHPQL 370
Query: 381 RTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431
TP+ + V + ++ AF + +++ S L +L I ++ LR++
Sbjct: 371 LTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHR 421
>gi|187423910 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 103 bits (256), Expect = 6e-22
Identities = 100/468 (21%), Positives = 199/468 (42%), Gaps = 47/468 (10%)
Query: 26 TRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAK--DKAGPSIVICFLVAALSSVLAGLC 83
T L + L + +++ VG+ +G+G++V V + GP ++I L++ L LC
Sbjct: 24 TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLAT-LGALC 82
Query: 84 YAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNH 143
+AE G + +SG Y Y G + A+ W ++ VI S A S + +
Sbjct: 83 FAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLI--VIKPTSFAIICLSFSEYVCAPF 140
Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203
+ P ++ + A +L ++ + +L + V +FT L+++
Sbjct: 141 Y-------VGCKPPQIVVKC---LAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAI 190
Query: 204 VMISGFV---KGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATC 260
++ISG V +G+ N+ + E +L++ ++ + G
Sbjct: 191 IIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNG---------------------- 228
Query: 261 FYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESP 320
+A+ G++ + EE +NP R++P+ I+I + + Y ++ + +M +L
Sbjct: 229 LWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQA 288
Query: 321 LPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGT 380
+ F PA ++V + + + G+ F R+IY +G + +VL+ I
Sbjct: 289 VAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRR 348
Query: 381 RTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGE 440
TP A + GIIA + LV+ S L Y L + ++++R+ T +
Sbjct: 349 LTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF-------TRK 401
Query: 441 EVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLL 488
E+E + +TL +F L I + + + +Y +L+ LL
Sbjct: 402 ELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLL 449
>gi|7657591 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 103 bits (256), Expect = 6e-22
Identities = 100/468 (21%), Positives = 199/468 (42%), Gaps = 47/468 (10%)
Query: 26 TRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAK--DKAGPSIVICFLVAALSSVLAGLC 83
T L + L + +++ VG+ +G+G++V V + GP ++I L++ L LC
Sbjct: 24 TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLAT-LGALC 82
Query: 84 YAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNH 143
+AE G + +SG Y Y G + A+ W ++ VI S A S + +
Sbjct: 83 FAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLI--VIKPTSFAIICLSFSEYVCAPF 140
Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203
+ P ++ + A +L ++ + +L + V +FT L+++
Sbjct: 141 Y-------VGCKPPQIVVKC---LAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAI 190
Query: 204 VMISGFV---KGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATC 260
++ISG V +G+ N+ + E +L++ ++ + G
Sbjct: 191 IIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNG---------------------- 228
Query: 261 FYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESP 320
+A+ G++ + EE +NP R++P+ I+I + + Y ++ + +M +L
Sbjct: 229 LWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQA 288
Query: 321 LPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGT 380
+ F PA ++V + + + G+ F R+IY +G + +VL+ I
Sbjct: 289 VAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRR 348
Query: 381 RTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGE 440
TP A + GIIA + LV+ S L Y L + ++++R+ T +
Sbjct: 349 LTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF-------TRK 401
Query: 441 EVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLL 488
E+E + +TL +F L I + + + +Y +L+ LL
Sbjct: 402 ELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLL 449
>gi|7657683 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 11 [Homo sapiens]
Length = 501
Score = 98.2 bits (243), Expect = 2e-20
Identities = 98/421 (23%), Positives = 182/421 (43%), Gaps = 47/421 (11%)
Query: 22 GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD--KAGPSIVICFLVAALSSVL 79
G + +L R ++ L V++ +G+ +GAG+++ V ++ G S+ I + V + S+
Sbjct: 34 GQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTI-WTVCGVLSLF 92
Query: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGW-NLILSYVIGTASVARAWSSAFDN 138
L YAE G + +SG Y Y G L AF W L++ TA ++ A+
Sbjct: 93 GALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAF------ 146
Query: 139 LIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNL 198
G +I + I +P + + + +V++L ++ S SA + T L
Sbjct: 147 --GRYILEPF--FIQCEIPELAIKLITAVGITVVMVLN---SMSVSWSARIQIFLTFCKL 199
Query: 199 LVLGFVMISG---FVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILR 255
+ +++ G +KG N+K + ++ L + G
Sbjct: 200 TAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYG----------------- 242
Query: 256 GAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQL 315
YA+ G+ + EE +NP+++IP+ I IS+++ + Y + A + +L
Sbjct: 243 -----MYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEEL 297
Query: 316 QPESPLPEAFLYIGWAPARYVVAVGSLCALST--SLLGSMFPMPRVIYAMAEDGLLFRVL 373
+ + A + + +AV ALS S+ G +F + R+ Y + +G L +L
Sbjct: 298 LLSNAV--AVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEIL 355
Query: 374 ARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ-P 432
+ IH TP+ A +V + M F L L++ +S L L ++ LRY+ P
Sbjct: 356 SMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCP 415
Query: 433 D 433
D
Sbjct: 416 D 416
>gi|186910308 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 90.1 bits (222), Expect = 5e-18
Identities = 99/427 (23%), Positives = 172/427 (40%), Gaps = 57/427 (13%)
Query: 22 GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVL 79
G + +L + +S L+ V L VG+ +G+G++V V A G S+VI + V L SV
Sbjct: 27 GPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVF 85
Query: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNL 139
LCYAE G + +SG++Y Y G AF W +L +I S A
Sbjct: 86 GALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-----IIAIT 138
Query: 140 IGNHISKTLQGSIALHVPHVLAEY--PDFFALGLVLLLTGLLALGASESALVTKVFTGVN 197
N++ + L P A Y A + LLT + LV +FT
Sbjct: 139 FANYMVQPL-------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAK 191
Query: 198 LLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPF--GFEG--- 252
+L L V+++G V+ LG G F FEG
Sbjct: 192 VLALIAVIVAGIVR----------------------------LGQGASTHFENSFEGSSF 223
Query: 253 ----ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTL 308
I + +++ G+D + EE +NP+R++P+ I IS+ + + Y + A
Sbjct: 224 AVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYT 283
Query: 309 MMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL 368
++ + + F + +++ + + L S+ R+ + + +G
Sbjct: 284 VLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGH 343
Query: 369 LFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLIL 428
L + IH TP+ + + +GI+A + + L++ S L + L L
Sbjct: 344 LPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYL 403
Query: 429 RY-QPDQ 434
R+ +PD+
Sbjct: 404 RWKEPDR 410
>gi|186910306 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 90.1 bits (222), Expect = 5e-18
Identities = 99/427 (23%), Positives = 172/427 (40%), Gaps = 57/427 (13%)
Query: 22 GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVL 79
G + +L + +S L+ V L VG+ +G+G++V V A G S+VI + V L SV
Sbjct: 27 GPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVF 85
Query: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNL 139
LCYAE G + +SG++Y Y G AF W +L +I S A
Sbjct: 86 GALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-----IIAIT 138
Query: 140 IGNHISKTLQGSIALHVPHVLAEY--PDFFALGLVLLLTGLLALGASESALVTKVFTGVN 197
N++ + L P A Y A + LLT + LV +FT
Sbjct: 139 FANYMVQPL-------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAK 191
Query: 198 LLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPF--GFEG--- 252
+L L V+++G V+ LG G F FEG
Sbjct: 192 VLALIAVIVAGIVR----------------------------LGQGASTHFENSFEGSSF 223
Query: 253 ----ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTL 308
I + +++ G+D + EE +NP+R++P+ I IS+ + + Y + A
Sbjct: 224 AVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYT 283
Query: 309 MMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL 368
++ + + F + +++ + + L S+ R+ + + +G
Sbjct: 284 VLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGH 343
Query: 369 LFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLIL 428
L + IH TP+ + + +GI+A + + L++ S L + L L
Sbjct: 344 LPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYL 403
Query: 429 RY-QPDQ 434
R+ +PD+
Sbjct: 404 RWKEPDR 410
>gi|186910304 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 90.1 bits (222), Expect = 5e-18
Identities = 99/427 (23%), Positives = 172/427 (40%), Gaps = 57/427 (13%)
Query: 22 GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVL 79
G + +L + +S L+ V L VG+ +G+G++V V A G S+VI + V L SV
Sbjct: 27 GPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVF 85
Query: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNL 139
LCYAE G + +SG++Y Y G AF W +L +I S A
Sbjct: 86 GALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-----IIAIT 138
Query: 140 IGNHISKTLQGSIALHVPHVLAEY--PDFFALGLVLLLTGLLALGASESALVTKVFTGVN 197
N++ + L P A Y A + LLT + LV +FT
Sbjct: 139 FANYMVQPL-------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAK 191
Query: 198 LLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPF--GFEG--- 252
+L L V+++G V+ LG G F FEG
Sbjct: 192 VLALIAVIVAGIVR----------------------------LGQGASTHFENSFEGSSF 223
Query: 253 ----ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTL 308
I + +++ G+D + EE +NP+R++P+ I IS+ + + Y + A
Sbjct: 224 AVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYT 283
Query: 309 MMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL 368
++ + + F + +++ + + L S+ R+ + + +G
Sbjct: 284 VLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGH 343
Query: 369 LFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLIL 428
L + IH TP+ + + +GI+A + + L++ S L + L L
Sbjct: 344 LPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYL 403
Query: 429 RY-QPDQ 434
R+ +PD+
Sbjct: 404 RWKEPDR 410
>gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo
sapiens]
Length = 535
Score = 86.7 bits (213), Expect = 6e-17
Identities = 111/517 (21%), Positives = 205/517 (39%), Gaps = 83/517 (16%)
Query: 21 SGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSI-VICFLVAALSSVL 79
SG L + + + + VG+ +G+G++V V ++ + +I ++V +V+
Sbjct: 29 SGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVV 88
Query: 80 AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLIL-SYVIGTASVARAWSSAFDN 138
LCYAE G +P+SG Y Y G L F W +L Y A +A +S
Sbjct: 89 GALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFS----- 143
Query: 139 LIGNHISKTLQGSIALHVPHVLAEYPDFFALGL-----VLLLTGLLALGASESALVTKVF 193
N++ + L + +P L L +LLLT + + V +F
Sbjct: 144 ---NYVLQPLFPTC----------FPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIF 190
Query: 194 TGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGI 253
T LL L ++I G V ++ + +Y E + + G V F
Sbjct: 191 TAGKLLALALIIIMGIV-------QICKGEY--FWLEPKNAFENFQEPDIGLVALAF--- 238
Query: 254 LRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYY 313
L+G+ +A+ G++ + EE +P +++P I IS+ + Y + A M
Sbjct: 239 LQGS----FAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQ 294
Query: 314 QLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVL 373
+L + + F +++ + + + GS+F R+ +A A +G L VL
Sbjct: 295 ELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVL 354
Query: 374 ARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY-QP 432
A IH TPI A + + I M + L++ + L Y + ++LR+ +P
Sbjct: 355 AMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKP 414
Query: 433 DQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALC 492
D IP P+ +++ ++ +L A
Sbjct: 415 D----------------------------------IPRPIKINLLF---PIIYLLFWAFL 437
Query: 493 LVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWR 529
LV + WS P++ G + ++L + + + V W+
Sbjct: 438 LVFSLWSEPVVCG----IGLAIMLTGVPVYFLGVYWQ 470
>gi|115648063 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 6 [Homo sapiens]
Length = 515
Score = 85.5 bits (210), Expect = 1e-16
Identities = 92/408 (22%), Positives = 173/408 (42%), Gaps = 36/408 (8%)
Query: 27 RLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVLAGLCY 84
+L + +S L+ V+L VG+ +G+G++V V A G S+++ + + L SV+ LCY
Sbjct: 40 QLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIV-WAIGGLFSVVGALCY 98
Query: 85 AEFGARVPRSGSAYLYSYVTVGELWAFTTGW-NLILSYVIGTASVARAWSSAFDNLIGNH 143
AE G + +SG++Y Y G AF W +L++ G A +A F N I
Sbjct: 99 AELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIA----ITFANYI--- 151
Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203
+Q S P LA A + LLT + V FT ++ L
Sbjct: 152 ----IQPSFPSCDPPYLA--CRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIA 205
Query: 204 VMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYA 263
+++ G VK + + ++ +E ++ +G L + + ++
Sbjct: 206 IIVMGLVKLCQGHSEHFQDAFE------GSSWDMGNLSLALY-------------SALFS 246
Query: 264 FVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPE 323
+ G+D + EE +NP+R++P+ I IS+ + L Y + A ++ + +
Sbjct: 247 YSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAV 306
Query: 324 AFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTP 383
F + + + + + L S+F R+ + + +G L +L+ IH TP
Sbjct: 307 TFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTP 366
Query: 384 IIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431
I A + + +A + + L++ S L + L LR++
Sbjct: 367 IPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWK 414
>gi|115648022 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 6 [Homo sapiens]
Length = 515
Score = 85.5 bits (210), Expect = 1e-16
Identities = 92/408 (22%), Positives = 173/408 (42%), Gaps = 36/408 (8%)
Query: 27 RLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVLAGLCY 84
+L + +S L+ V+L VG+ +G+G++V V A G S+++ + + L SV+ LCY
Sbjct: 40 QLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIV-WAIGGLFSVVGALCY 98
Query: 85 AEFGARVPRSGSAYLYSYVTVGELWAFTTGW-NLILSYVIGTASVARAWSSAFDNLIGNH 143
AE G + +SG++Y Y G AF W +L++ G A +A F N I
Sbjct: 99 AELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIA----ITFANYI--- 151
Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203
+Q S P LA A + LLT + V FT ++ L
Sbjct: 152 ----IQPSFPSCDPPYLA--CRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIA 205
Query: 204 VMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYA 263
+++ G VK + + ++ +E ++ +G L + + ++
Sbjct: 206 IIVMGLVKLCQGHSEHFQDAFE------GSSWDMGNLSLALY-------------SALFS 246
Query: 264 FVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPE 323
+ G+D + EE +NP+R++P+ I IS+ + L Y + A ++ + +
Sbjct: 247 YSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAV 306
Query: 324 AFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTP 383
F + + + + + L S+F R+ + + +G L +L+ IH TP
Sbjct: 307 TFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTP 366
Query: 384 IIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431
I A + + +A + + L++ S L + L LR++
Sbjct: 367 IPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWK 414
>gi|9790235 solute carrier family 7, member 10 [Homo sapiens]
Length = 523
Score = 80.1 bits (196), Expect = 6e-15
Identities = 94/420 (22%), Positives = 178/420 (42%), Gaps = 39/420 (9%)
Query: 18 TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVI-CFLVAALS 76
T+ L + + L + +G+ +G+G+++ V + + + +++
Sbjct: 26 TVPGASERVALKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGV 85
Query: 77 SVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAF 136
+ L LCYAE G +P+SG Y Y G L F W+ +L ++ S+A S F
Sbjct: 86 TALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVL--IMYPTSLA-VISMTF 142
Query: 137 DNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGV 196
N + LQ +P A ++ ++LLT + + + + +FTG
Sbjct: 143 SNYV-------LQPVFPNCIPPTTAS--RVLSMACLMLLTWVNSSSVRWATRIQDMFTGG 193
Query: 197 NLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRG 256
LL L ++ G + ++ + +E ++ ++ S G + F L+G
Sbjct: 194 KLLALSLIIGVGLL-------QIFQGHFE--ELRPSNAFAFWMTPSVGHLALAF---LQG 241
Query: 257 AATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLS-VCFLAYFAVSSALTLMMPYYQL 315
+ +AF G++ + EE + ++++P I IS+ V F+ F + T M P L
Sbjct: 242 S----FAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELL 297
Query: 316 QPES---PLPEAFL-YIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFR 371
+ E L Y W V+ V + + G +F R+ ++ A +G L
Sbjct: 298 SSNAVAVTFGEKLLGYFSW-----VMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPS 352
Query: 372 VLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431
+LA IH TPI A +V A + + L++ +S L Y + + +L+LR++
Sbjct: 353 LLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWR 412
>gi|71999149 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 13 [Homo sapiens]
Length = 470
Score = 60.5 bits (145), Expect = 5e-09
Identities = 94/399 (23%), Positives = 168/399 (42%), Gaps = 54/399 (13%)
Query: 46 LGAGVYVLA-GEVAKDKAGPSIVICFLVA-ALSSVLAGLCYAEFGARVPRSGSAYLYSYV 103
+GAG++V G +A + +C A+ ++ + LC AE P SG+ Y +
Sbjct: 27 IGAGIFVSPKGVLAYSCMNVGVSLCVWAGCAILAMTSTLCSAEISISFPCSGAQYYFLKR 86
Query: 104 TVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEY 163
G AF W S +G+ VA A L+ + + S + VP + +
Sbjct: 87 YFGSTVAFLNLWT---SLFLGSGVVA---GQAL--LLAEYSIQPFFPSCS--VPKLPKK- 135
Query: 164 PDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVMISG---FVKGDVHNWKLT 220
AL ++ ++ L + G E + + + + +L F+ ++G ++G N +
Sbjct: 136 --CLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVERF 193
Query: 221 EEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNP 280
+ ++ AEL D L + I +G ++A+ G C E + P
Sbjct: 194 QNAFD---AELPDISHL------------IQAIFQG----YFAYSGGACFTLIAGELKKP 234
Query: 281 QRSIPMGIVISLSVCFLAYFAVS-SALTLMMPYYQLQPESP----LPEAFLYIGWAPARY 335
+ +IP I +L + + Y V+ S LT++ P L ++ AF + W
Sbjct: 235 RTTIPKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDAVAITWADRAFPSLAW----- 289
Query: 336 VVAVGSLCALSTSLLGSMFPMPRVIYAMAEDG---LLFRVLARIHTGTRTPIIATVVSGI 392
++ +L ++LL S+F R IY +++G LLF L H+ T ++ V G
Sbjct: 290 IMPFAISTSLFSNLLISIFKSSRPIYLASQEGQLPLLFNTL-NSHSSPFTAVLLLVTLGS 348
Query: 393 IAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431
+A L L DL++ + L L+ I +L RYQ
Sbjct: 349 LA---IILTSLIDLINYIFFTGSLWSILLMIGILRRRYQ 384
Score = 31.2 bits (69), Expect = 3.0
Identities = 29/100 (29%), Positives = 54/100 (54%), Gaps = 14/100 (14%)
Query: 461 LFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLI 520
LF LNS +P + ++ V LA++LT+L ++ + +G LW+ +LL+
Sbjct: 326 LFNTLNSHSSPFTAVLLLVTLGSLAIILTSLIDLI---NYIFFTGS-LWS------ILLM 375
Query: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMM 560
IGI+ +++P S P +KV PL +I +++ L++
Sbjct: 376 IGILRRRYQEPNLSIP--YKV--FLSFPLATIVIDVGLVV 411
>gi|33286430 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform b [Homo
sapiens]
Length = 332
Score = 52.4 bits (124), Expect = 1e-06
Identities = 54/269 (20%), Positives = 107/269 (39%), Gaps = 42/269 (15%)
Query: 262 YAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPL 321
+A+ G++ + EE +P +++P I IS+ + Y + A M +L + +
Sbjct: 40 FAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAV 99
Query: 322 PEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTR 381
F +++ + + + GS+F R+ +A A +G L VLA IH
Sbjct: 100 AVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRC 159
Query: 382 TPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY-QPDQETKTGE 440
TPI A + + I M + L++ + L Y + ++LR+ +PD
Sbjct: 160 TPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPD------- 212
Query: 441 EVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSV 500
IP P+ +++ ++ +L A LV + WS
Sbjct: 213 ---------------------------IPRPIKINLLF---PIIYLLFWAFLLVFSLWSE 242
Query: 501 PLLSGDLLWTAVVVLLLLLIIGIIVVIWR 529
P++ G + ++L + + + V W+
Sbjct: 243 PVVCG----IGLAIMLTGVPVYFLGVYWQ 267
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 48.1 bits (113), Expect = 2e-05
Identities = 40/175 (22%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 258 ATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQP 317
A F G A E ++P R+IP+G +++++ F Y + + LQ
Sbjct: 272 AVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQE 331
Query: 318 ESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIH 377
+ A W P +V +G ++ + S+ R+++A+A D L +LA
Sbjct: 332 DYGFFRAISL--WPP---LVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAK 386
Query: 378 TGTR--TPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY 430
+R P A + S + + KL L ++++ L+AY+ V + L L +
Sbjct: 387 VVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEW 441
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 44.3 bits (103), Expect = 3e-04
Identities = 82/389 (21%), Positives = 156/389 (40%), Gaps = 47/389 (12%)
Query: 63 GPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYV 122
G +V ++ AL +VL+G+ E + GS +YS ++ + TG + L YV
Sbjct: 74 GMFLVSFVILVALVTVLSGIGVGERSS----IGSGGVYSMIS--SVLGGQTGGTIGLLYV 127
Query: 123 IGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALG 182
G + + F I + L + +A+ + + L LG
Sbjct: 128 FGQCVAGAMYITGFAESISD-----------------LLGLGNIWAVRGISVAVLLALLG 170
Query: 183 ASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGS 242
+ + + + + LL L V FV G + E + EL +L P S
Sbjct: 171 INLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLD-PEHGFIGYSPELLQNNTL-PDYS 228
Query: 243 GGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAV 302
G F G+ AAT A GF+ G + + P SIP+G + ++ + + Y
Sbjct: 229 PGESFFTVFGVFFPAATGVMA--GFNM----GGDLREPAASIPLGSLAAVGISWFLYIVF 282
Query: 303 SSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYA 362
L + L+ + + E +G ++ +G + S +G ++ PR++
Sbjct: 283 VFLLGAICTREALRYDFLIAEKVSLMG-----FLFLLGLYISSLASCMGGLYGAPRILQC 337
Query: 363 MAEDGLLFRVLARIHTG---TRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYS 419
+A++ ++ LA + G +TP+ A ++ ++ F+ ++ L +++I +L Y
Sbjct: 338 IAQEKVI-PALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYV 396
Query: 420 LV-------SICVLILRYQPDQETKTGEE 441
V S+C L P+ + G E
Sbjct: 397 AVDYSYFSLSMCSCSLTPVPEPVLREGAE 425
>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
sapiens]
Length = 1054
Score = 39.3 bits (90), Expect = 0.011
Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+
Sbjct: 381 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 440
Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
+ L+ + L +G W P+ +V+ +GS + + L S+ PR++
Sbjct: 441 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 499
Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y
Sbjct: 500 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 558
Query: 419 SLVSICVLI 427
V++ +
Sbjct: 559 LFVNLACAV 567
>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
sapiens]
Length = 1079
Score = 39.3 bits (90), Expect = 0.011
Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+
Sbjct: 406 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 465
Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
+ L+ + L +G W P+ +V+ +GS + + L S+ PR++
Sbjct: 466 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 524
Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y
Sbjct: 525 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 583
Query: 419 SLVSICVLI 427
V++ +
Sbjct: 584 LFVNLACAV 592
>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
sapiens]
Length = 1087
Score = 39.3 bits (90), Expect = 0.011
Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+
Sbjct: 414 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 473
Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
+ L+ + L +G W P+ +V+ +GS + + L S+ PR++
Sbjct: 474 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 532
Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y
Sbjct: 533 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 591
Query: 419 SLVSICVLI 427
V++ +
Sbjct: 592 LFVNLACAV 600
>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
sapiens]
Length = 1079
Score = 39.3 bits (90), Expect = 0.011
Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+
Sbjct: 412 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 471
Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
+ L+ + L +G W P+ +V+ +GS + + L S+ PR++
Sbjct: 472 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 530
Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y
Sbjct: 531 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 589
Query: 419 SLVSICVLI 427
V++ +
Sbjct: 590 LFVNLACAV 598
>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
sapiens]
Length = 1085
Score = 39.3 bits (90), Expect = 0.011
Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
++ AT F VG + TG A ++ Q+SIP+G ++++ L YF+
Sbjct: 412 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 471
Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
+ L+ + L +G W P+ +V+ +GS + + L S+ PR++
Sbjct: 472 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 530
Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
A+A+D ++ RV P A +++ +IA + L + ++S+ L+ Y
Sbjct: 531 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 589
Query: 419 SLVSICVLI 427
V++ +
Sbjct: 590 LFVNLACAV 598
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 37.7 bits (86), Expect = 0.032
Identities = 56/288 (19%), Positives = 114/288 (39%), Gaps = 51/288 (17%)
Query: 175 LTGLLALGASESALVTKVFTGVNLLVLGFVMISGFVKGDV---HNWKLTEEDYELAMAEL 231
+T ++ LG S + + + V LLV+ + I+ F G V +N K + + +
Sbjct: 307 ITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIF 366
Query: 232 NDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVIS 291
+ + GP + G EG A F A G A + ++PQ +IP G +++
Sbjct: 367 AENF--GPRFTKG------EGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLA 418
Query: 292 LSVCFLAYFAV----------------------------SSALTLMMPYYQLQPE----- 318
+ + +AY V S+A L + + + E
Sbjct: 419 IFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYG 478
Query: 319 --SPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL--LFRVLA 374
+ + G+ P ++ G A +S L S+ P+V A+ +D + + A
Sbjct: 479 LMNNFQVMSMVSGFGP---LITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA 535
Query: 375 RIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVS 422
+ + P+ +++ +IA + +L + ++S L +Y+L++
Sbjct: 536 KGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALIN 583
>gi|198041678 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 1 [Homo sapiens]
Length = 1139
Score = 36.6 bits (83), Expect = 0.070
Identities = 56/270 (20%), Positives = 112/270 (41%), Gaps = 25/270 (9%)
Query: 175 LTGLLALGASESALVTKVFTGVNLLVLGFV--MISGFVKGDVHNWKLTEEDYELAMAELN 232
L GL +A + FT N+ + + SG +K ++ + LT+ + E +
Sbjct: 340 LWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKG----VIVERS 395
Query: 233 DTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSI 284
S+G L G + + + F VG + TG A ++ Q+SI
Sbjct: 396 GMTSVG-LADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSI 454
Query: 285 PMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAF---LYIG---WAPARYVVA 338
P G +++++ Y +SS + + EA L +G W P+ +V+
Sbjct: 455 PTGTILAIATTSAVY--ISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAW-PSPWVIV 511
Query: 339 VGSLCALSTSLLGSMFPMPRVIYAMAEDGLL-FRVLARIHTGTRTPIIATVVSGIIAAFM 397
+GS + + L S+ PR++ A++ DG++ F + P A +++ I
Sbjct: 512 IGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIG 571
Query: 398 AFLFKLTDLVDLMSIGTLLAYSLVSICVLI 427
+ L ++ ++S+ L+ Y V++ +
Sbjct: 572 ILIASLDEVAPILSMFFLMCYMFVNLACAV 601
>gi|11968148 solute carrier family 12 (potassium-chloride
transporter), member 5 isoform 2 [Homo sapiens]
Length = 1116
Score = 36.6 bits (83), Expect = 0.070
Identities = 56/270 (20%), Positives = 112/270 (41%), Gaps = 25/270 (9%)
Query: 175 LTGLLALGASESALVTKVFTGVNLLVLGFV--MISGFVKGDVHNWKLTEEDYELAMAELN 232
L GL +A + FT N+ + + SG +K ++ + LT+ + E +
Sbjct: 317 LWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKG----VIVERS 372
Query: 233 DTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSI 284
S+G L G + + + F VG + TG A ++ Q+SI
Sbjct: 373 GMTSVG-LADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSI 431
Query: 285 PMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAF---LYIG---WAPARYVVA 338
P G +++++ Y +SS + + EA L +G W P+ +V+
Sbjct: 432 PTGTILAIATTSAVY--ISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAW-PSPWVIV 488
Query: 339 VGSLCALSTSLLGSMFPMPRVIYAMAEDGLL-FRVLARIHTGTRTPIIATVVSGIIAAFM 397
+GS + + L S+ PR++ A++ DG++ F + P A +++ I
Sbjct: 489 IGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIG 548
Query: 398 AFLFKLTDLVDLMSIGTLLAYSLVSICVLI 427
+ L ++ ++S+ L+ Y V++ +
Sbjct: 549 ILIASLDEVAPILSMFFLMCYMFVNLACAV 578
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.140 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,824,446
Number of Sequences: 37866
Number of extensions: 934559
Number of successful extensions: 3410
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 3307
Number of HSP's gapped (non-prelim): 65
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.