Guide to the Human Genome
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Search of human proteins with 114326544

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
         (619 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|114326550 solute carrier family 7 (cationic amino acid transp...  1217   0.0  
gi|114326544 solute carrier family 7 (cationic amino acid transp...  1217   0.0  
gi|4507047 solute carrier family 7 (cationic amino acid transpor...   724   0.0  
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s...   677   0.0  
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s...   664   0.0  
gi|110347453 solute carrier family 7 (cationic amino acid transp...   477   e-134
gi|181337167 solute carrier family 7 (cationic amino acid transp...   404   e-112
gi|71979932 solute carrier family 7 (cationic amino acid transpo...   108   1e-23
gi|187423910 solute carrier family 7, member 9 [Homo sapiens]         103   6e-22
gi|7657591 solute carrier family 7, member 9 [Homo sapiens]           103   6e-22
gi|7657683 solute carrier family 7, (cationic amino acid transpo...    98   2e-20
gi|186910308 solute carrier family 7 member 7 [Homo sapiens]           90   5e-18
gi|186910306 solute carrier family 7 member 7 [Homo sapiens]           90   5e-18
gi|186910304 solute carrier family 7 member 7 [Homo sapiens]           90   5e-18
gi|33286428 solute carrier family 7 (cationic amino acid transpo...    87   6e-17
gi|115648063 solute carrier family 7 (cationic amino acid transp...    86   1e-16
gi|115648022 solute carrier family 7 (cationic amino acid transp...    86   1e-16
gi|9790235 solute carrier family 7, member 10 [Homo sapiens]           80   6e-15
gi|71999149 solute carrier family 7, (cationic amino acid transp...    60   5e-09
gi|33286430 solute carrier family 7 (cationic amino acid transpo...    52   1e-06
gi|31881740 solute carrier family 12 (potassium/chloride transpo...    48   2e-05
gi|38569457 solute carrier family 12, member 8 [Homo sapiens]          44   3e-04
gi|225579067 solute carrier family 12, member 4 isoform e [Homo ...    39   0.011
gi|225579065 solute carrier family 12, member 4 isoform d [Homo ...    39   0.011
gi|225579063 solute carrier family 12, member 4 isoform c [Homo ...    39   0.011
gi|225579061 solute carrier family 12, member 4 isoform b [Homo ...    39   0.011
gi|4827006 solute carrier family 12, member 4 isoform a [Homo sa...    39   0.011
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap...    38   0.032
gi|198041678 solute carrier family 12 (potassium-chloride transp...    37   0.070
gi|11968148 solute carrier family 12 (potassium-chloride transpo...    37   0.070

>gi|114326550 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 3 [Homo sapiens]
          Length = 619

 Score = 1217 bits (3149), Expect = 0.0
 Identities = 619/619 (100%), Positives = 619/619 (100%)

Query: 1   MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60
           MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD
Sbjct: 1   MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60

Query: 61  KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120
           KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS
Sbjct: 61  KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120

Query: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180
           YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA
Sbjct: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180

Query: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240
           LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL
Sbjct: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240

Query: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300
           GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF
Sbjct: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300

Query: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
           AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI
Sbjct: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360

Query: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420
           YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL
Sbjct: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420

Query: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480
           VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC
Sbjct: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480

Query: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540
           SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK
Sbjct: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540

Query: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600
           VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR
Sbjct: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600

Query: 601 KSRAKTVDLDPGTLYVHSV 619
           KSRAKTVDLDPGTLYVHSV
Sbjct: 601 KSRAKTVDLDPGTLYVHSV 619


>gi|114326544 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 3 [Homo sapiens]
          Length = 619

 Score = 1217 bits (3149), Expect = 0.0
 Identities = 619/619 (100%), Positives = 619/619 (100%)

Query: 1   MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60
           MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD
Sbjct: 1   MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD 60

Query: 61  KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120
           KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS
Sbjct: 61  KAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILS 120

Query: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180
           YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA
Sbjct: 121 YVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLA 180

Query: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240
           LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL
Sbjct: 181 LGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPL 240

Query: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300
           GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF
Sbjct: 241 GSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYF 300

Query: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
           AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI
Sbjct: 301 AVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360

Query: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420
           YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL
Sbjct: 361 YAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSL 420

Query: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480
           VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC
Sbjct: 421 VSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVC 480

Query: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540
           SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK
Sbjct: 481 SSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFK 540

Query: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600
           VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR
Sbjct: 541 VPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSR 600

Query: 601 KSRAKTVDLDPGTLYVHSV 619
           KSRAKTVDLDPGTLYVHSV
Sbjct: 601 KSRAKTVDLDPGTLYVHSV 619


>gi|4507047 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 1 [Homo sapiens]
          Length = 629

 Score =  724 bits (1869), Expect = 0.0
 Identities = 378/612 (61%), Positives = 458/612 (74%), Gaps = 41/612 (6%)

Query: 10  GQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVIC 69
           GQ+++RR+ ++    ETRL+RCL+T DLVALGVGSTLGAGVYVLAG VA++ AGP+IVI 
Sbjct: 10  GQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVIS 69

Query: 70  FLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVA 129
           FL+AAL+SVLAGLCY EFGARVP++GSAYLYSYVTVGELWAF TGWNLILSY+IGT+SVA
Sbjct: 70  FLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVA 129

Query: 130 RAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALV 189
           RAWS+ FD LIG  I +  +  + L+ P VLAE PD FA+ ++L+LTGLL LG  ESA+V
Sbjct: 130 RAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMV 189

Query: 190 TKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAEL---NDTYSLGPLGSGGFV 246
            K+FT +N+LVLGF+M+SGFVKG V NW+LTEED+      L   NDT   G  G GGF+
Sbjct: 190 NKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKE-GKPGVGGFM 248

Query: 247 PFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSAL 306
           PFGF G+L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL +CF+AYF VS+AL
Sbjct: 249 PFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAAL 308

Query: 307 TLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAED 366
           TLMMPY+ L   SPLP+AF ++GW  A+Y VAVGSLCALS SLLGSMFPMPRVIYAMAED
Sbjct: 309 TLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAED 368

Query: 367 GLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVL 426
           GLLF+ LA ++  T+TPIIAT+ SG +AA MAFLF L DLVDLMSIGTLLAYSLV+ CVL
Sbjct: 369 GLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVL 428

Query: 427 ILRYQPDQE------TKTGEEVEL--QEEAITT---------ESEKLTLWGLFFPLNSIP 469
           +LRYQP+Q         T +E++   Q E  +T         E+E  +L  +  P N  P
Sbjct: 429 VLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEP 488

Query: 470 TPLSGQIVYVCSSLLAVLLTALCLVL----------AQWSVPLLSGDLLWTAVVVLLLLL 519
           + +SG IV + +SL+AVL+   C+V           A W+V LL+G  L  AVV      
Sbjct: 489 SKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVT----- 543

Query: 520 IIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFA 579
                 VIWRQP+S T L FKVP LP+LP++SIFVN+YLMMQ+  GTW RF VWMLIGF 
Sbjct: 544 -----GVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFI 598

Query: 580 IYFGYGIQHSLE 591
           IYFGYG+ HS E
Sbjct: 599 IYFGYGLWHSEE 610


>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
           sapiens]
          Length = 658

 Score =  677 bits (1747), Expect = 0.0
 Identities = 365/611 (59%), Positives = 452/611 (73%), Gaps = 24/611 (3%)

Query: 1   MPWQAFRRFGQKLVRRR--TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVA 58
           +P +A   F + L+RR+  TL+S + +T+L RCLST+DL+ALGVGSTLGAGVYVLAGEVA
Sbjct: 2   IPCRAALTFARCLIRRKIVTLDS-LEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 60

Query: 59  KDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLI 118
           K  +GPSIV+ FL+AAL+SV+AGLCYAEFGARVP++GSAYLY+YVTVGELWAF TGWNLI
Sbjct: 61  KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 120

Query: 119 LSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGL 178
           LSYVIGT+SVARAWS  FD L+   I + L+    ++    LAEYPDFFA+ L+LLL GL
Sbjct: 121 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 179

Query: 179 LALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYS-- 236
           L+ G  ESA V KVFT VN+LVL FVM++GFVKG+V NWK++EE  +   A   +  S  
Sbjct: 180 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSEN 239

Query: 237 -LGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVC 295
                G+GGF+P+GF G L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL VC
Sbjct: 240 GTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVC 299

Query: 296 FLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFP 355
           F+AYF VS+ALTLMMPYY L  +SPLP AF Y+GW PA+YVVA GSLCALSTSLLGS+FP
Sbjct: 300 FMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFP 359

Query: 356 MPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTL 415
           MPRVIYAMAEDGLLF+ LA+I++ T+TPIIAT+ SG +AA MAFLF L  LVD+MSIGTL
Sbjct: 360 MPRVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTL 419

Query: 416 LAYSLVSICVLILRYQP----DQETKTGEEVEL-QEEAITTESEK---------LTLWGL 461
           +AYSLV+ CVLILRYQP    DQ   + E+  L     +T++SE           ++  L
Sbjct: 420 MAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTL 479

Query: 462 FFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWT-AVVVLLLLLI 520
           F P + +PT  S  +V      LA L+  L  VL  + V  ++    W+ A++ L L+L 
Sbjct: 480 FCP-SLLPTQQSASLVSFLVGFLAFLVLGLS-VLTTYGVHAITRLEAWSLALLALFLVLF 537

Query: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAI 580
           + I++ IWR PQ+   + F VP LP LP  SI VNIYLM+Q++A TW RF +WM IGF I
Sbjct: 538 VAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLI 597

Query: 581 YFGYGIQHSLE 591
           YF YGI+HSLE
Sbjct: 598 YFSYGIRHSLE 608


>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
           sapiens]
          Length = 697

 Score =  664 bits (1713), Expect = 0.0
 Identities = 357/611 (58%), Positives = 449/611 (73%), Gaps = 25/611 (4%)

Query: 1   MPWQAFRRFGQKLVRRR--TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVA 58
           +P +A   F + L+RR+  TL+S + +T+L RCLST+DL+ALGVGSTLGAGVYVLAGEVA
Sbjct: 42  IPCRAALTFARCLIRRKIVTLDS-LEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVA 100

Query: 59  KDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLI 118
           K  +GPSIV+ FL+AAL+SV+AGLCYAEFGARVP++GSAYLY+YVTVGELWAF TGWNLI
Sbjct: 101 KADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLI 160

Query: 119 LSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGL 178
           LSYVIGT+SVARAWS  FD L+   I + L+    ++    LAEYPDFFA+ L+LLL GL
Sbjct: 161 LSYVIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGL 219

Query: 179 LALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYS-- 236
           L+ G  ESA V KVFT VN+LVL FVM++GFVKG+V NWK++EE  +   A   +  S  
Sbjct: 220 LSFGVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISASAREPPSEN 279

Query: 237 -LGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVC 295
                G+GGF+P+GF G L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL VC
Sbjct: 280 GTSIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVC 339

Query: 296 FLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFP 355
           F+AYF VS+ALTLMMPYY L  +SPLP AF Y+GW PA+YVVA GSLCALSTSLLGSMFP
Sbjct: 340 FMAYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFP 399

Query: 356 MPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTL 415
           +PR+++AMA DGLLFR LAR+ +  ++P+ AT+ +G+I+A MAFLF L  LVD+MSIGTL
Sbjct: 400 LPRILFAMARDGLLFRFLARV-SKRQSPVAATLTAGVISALMAFLFDLKALVDMMSIGTL 458

Query: 416 LAYSLVSICVLILRYQP----DQETKTGEEVEL-QEEAITTESEK---------LTLWGL 461
           +AYSLV+ CVLILRYQP    DQ   + E+  L     +T++SE           ++  L
Sbjct: 459 MAYSLVAACVLILRYQPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTMLQRQGFSMRTL 518

Query: 462 FFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWT-AVVVLLLLLI 520
           F P + +PT  S  +V      LA L+  L  VL  + V  ++    W+ A++ L L+L 
Sbjct: 519 FCP-SLLPTQQSASLVSFLVGFLAFLVLGLS-VLTTYGVHAITRLEAWSLALLALFLVLF 576

Query: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAI 580
           + I++ IWR PQ+   + F VP LP LP  SI VNIYLM+Q++A TW RF +WM IGF I
Sbjct: 577 VAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFLI 636

Query: 581 YFGYGIQHSLE 591
           YF YGI+HSLE
Sbjct: 637 YFSYGIRHSLE 647


>gi|110347453 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 4 [Homo sapiens]
          Length = 635

 Score =  477 bits (1227), Expect = e-134
 Identities = 261/613 (42%), Positives = 374/613 (61%), Gaps = 62/613 (10%)

Query: 8   RFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIV 67
           R  QKL R + LE    ET L RCLSTLDL  LGVG  +G+G+YVL G VAK+ AGP+++
Sbjct: 13  RLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPAVL 72

Query: 68  ICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTAS 127
           + F VAA++S+LA LCYAEFGARVPR+GSAYL++YV++GELWAF  GWN++L Y+IG A+
Sbjct: 73  LSFGVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGGAA 132

Query: 128 VARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESA 187
           VARAWS   D++  + I    +  +      +L  YPDF A G++LL +  ++ GA  S+
Sbjct: 133 VARAWSGYLDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARVSS 192

Query: 188 LVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVP 247
            +   F+ ++LLV+ F++I GF+    HNW   E                     GGF P
Sbjct: 193 WLNHTFSAISLLVILFIVILGFILAQPHNWSADE---------------------GGFAP 231

Query: 248 FGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALT 307
           FGF G++ G A+CFYAFVGFD IA + EEAQNP+RS+P+ I ISL++   AY  VS+ LT
Sbjct: 232 FGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVSTVLT 291

Query: 308 LMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDG 367
           LM+P++ L P+S L +AF   G+  A ++VA GS+CA++T LL  +F +PR++YAMA DG
Sbjct: 292 LMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAMAADG 351

Query: 368 LLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLI 427
           L F+V A +H  T+ P+  T+  G++ AF+A L  L  LV  +S+GTLLAY+ V+  +++
Sbjct: 352 LFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVATSIIV 411

Query: 428 LRYQ---PDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTP------------- 471
           LR+Q   P           L ++  ++ S+ L L G      S+P P             
Sbjct: 412 LRFQKSSPPSSPGPASPGPLTKQQ-SSFSDHLQLVGTVHA--SVPEPGELKPALRPYLGF 468

Query: 472 LSGQ-----IVYVCSSLLAVLLTALCLV--------LAQWSVPLLSGDLLWTAVVVLLLL 518
           L G      + +    +LA  +T  C++        L  W   LL   LL T+V+ LL L
Sbjct: 469 LDGYSPGAVVTWALGVMLASAITIGCVLVFGNSTLHLPHWGYILL---LLLTSVMFLLSL 525

Query: 519 LIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGF 578
           L++G       Q Q    L F++P +PL+P +SI +NI LM++++  TW RF +W+L+G 
Sbjct: 526 LVLGA-----HQQQYREDL-FQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIWLLMGL 579

Query: 579 AIYFGYGIQHSLE 591
           A+YFGYGI+HS E
Sbjct: 580 AVYFGYGIRHSKE 592


>gi|181337167 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 14 [Homo sapiens]
          Length = 771

 Score =  404 bits (1038), Expect = e-112
 Identities = 217/438 (49%), Positives = 293/438 (66%), Gaps = 31/438 (7%)

Query: 26  TRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYA 85
           T+LA+ L+T+DL++LGVGS +G G+YV++G VAK+ AGP +++ F++AA++S+L+G+CYA
Sbjct: 47  TKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYA 106

Query: 86  EFGARVPRS-GSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHI 144
           EFG RVP++ GSAY YSYVTVGE  AF  GWNLIL Y+IGTA+ A A SS FD+L  + I
Sbjct: 107 EFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTI 166

Query: 145 SKTLQGSIALHVPHVLAE--YPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLG 202
           S+ +  S+         E  YPD  AL + +++T ++ALG   S     V   +NL V  
Sbjct: 167 SRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWV 226

Query: 203 FVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFY 262
           F+MI+G    +   W                         G F+P G+ G+L+GAATCFY
Sbjct: 227 FIMIAGLFFINGKYW-----------------------AEGQFLPHGWSGVLQGAATCFY 263

Query: 263 AFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLP 322
           AF+GFD IATTGEEA+NP  SIP  I  SL +C  AY +VS  LTLM+PYY +  ESPL 
Sbjct: 264 AFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLM 323

Query: 323 EAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRT 382
           E F+  G+  A++VVA+GS+  L+ SLLGS+FPMPRVIYAMA DGLLFR LA + + T T
Sbjct: 324 EMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYTET 383

Query: 383 PIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETK----- 437
           P++A +VSG +AA +A L  L DL+++MSIGTLLAY+LVS+CVL+LRYQP+ +       
Sbjct: 384 PVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPESDIDGFVKF 443

Query: 438 TGEEVELQEEAITTESEK 455
             EE   ++E I  + EK
Sbjct: 444 LSEEHTKKKEGILADCEK 461



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 52/144 (36%), Positives = 84/144 (58%), Gaps = 3/144 (2%)

Query: 469 PTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIV-VI 527
           PT  +G  V +C  LL +L+   C  +   S   +S    W  ++V+L++L+I  +V VI
Sbjct: 557 PTAATGHTVTICVLLLFILMFIFCSFIIFGS-DYISEQSWWAILLVVLMVLLISTLVFVI 615

Query: 528 WRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQ 587
            +QP++   L +  P LP +P  ++ VNIYLM++++  TW RF VW  +G  IYFGYGI 
Sbjct: 616 LQQPENPKKLPYMAPCLPFVPAFAMLVNIYLMLKLSTITWIRFAVWCFVGLLIYFGYGIW 675

Query: 588 HSLEEIKSNQPS-RKSRAKTVDLD 610
           +S  EI + + +  +S  +  D+D
Sbjct: 676 NSTLEISAREEALHQSTYQRYDVD 699


>gi|71979932 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 5 [Homo sapiens]
          Length = 507

 Score =  108 bits (271), Expect = 1e-23
 Identities = 105/411 (25%), Positives = 179/411 (43%), Gaps = 42/411 (10%)

Query: 28  LARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSI-VICFLVAALSSVLAGLCYAE 86
           L R ++ L+ VA+ VG+ +G+G++V    V K+   P + ++ +    + S++  LCYAE
Sbjct: 46  LQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLALVVWAACGVFSIVGALCYAE 105

Query: 87  FGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLI-GNHIS 145
            G  + +SG  Y Y     G L AF   W  +L        + R  S     L+   ++ 
Sbjct: 106 LGTTISKSGGDYAYMLEVYGSLPAFLKLWIELL--------IIRPSSQYIVALVFATYLL 157

Query: 146 KTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVM 205
           K L  +    VP   A+     A   VLLLT +       +  V   F    LL L  ++
Sbjct: 158 KPLFPTCP--VPEEAAK---LVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALII 212

Query: 206 ISGFV---KGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFY 262
           + GFV   KGDV N             + N ++    L  G  V   + G+        +
Sbjct: 213 LLGFVQIGKGDVSN------------LDPNFSFEGTKLDVGNIVLALYSGL--------F 252

Query: 263 AFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLP 322
           A+ G++ +    EE  NP R++P+ I+ISL +  L Y   + A    +   Q+     + 
Sbjct: 253 AYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTEQMLSSEAVA 312

Query: 323 EAF--LYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGT 380
             F   ++G       V VG  C  S +  GS+F   R+ +  + +G L  +L+ IH   
Sbjct: 313 VDFGNYHLGVMSWIIPVFVGLSCFGSVN--GSLFTSSRLFFVGSREGHLPSILSMIHPQL 370

Query: 381 RTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431
            TP+ + V + ++    AF   +  +++  S    L  +L  I ++ LR++
Sbjct: 371 LTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLCVALAIIGMIWLRHR 421


>gi|187423910 solute carrier family 7, member 9 [Homo sapiens]
          Length = 487

 Score =  103 bits (256), Expect = 6e-22
 Identities = 100/468 (21%), Positives = 199/468 (42%), Gaps = 47/468 (10%)

Query: 26  TRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAK--DKAGPSIVICFLVAALSSVLAGLC 83
           T L + L  +  +++ VG+ +G+G++V    V    +  GP ++I      L++ L  LC
Sbjct: 24  TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLAT-LGALC 82

Query: 84  YAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNH 143
           +AE G  + +SG  Y Y     G + A+   W  ++  VI   S A    S  + +    
Sbjct: 83  FAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLI--VIKPTSFAIICLSFSEYVCAPF 140

Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203
                   +    P ++ +     A   +L ++ + +L     + V  +FT   L+++  
Sbjct: 141 Y-------VGCKPPQIVVKC---LAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAI 190

Query: 204 VMISGFV---KGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATC 260
           ++ISG V   +G+  N+  + E  +L++  ++  +  G                      
Sbjct: 191 IIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNG---------------------- 228

Query: 261 FYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESP 320
            +A+ G++ +    EE +NP R++P+ I+I + +    Y  ++ +   +M   +L     
Sbjct: 229 LWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQA 288

Query: 321 LPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGT 380
           +   F      PA ++V +    +   +  G+ F   R+IY    +G + +VL+ I    
Sbjct: 289 VAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRR 348

Query: 381 RTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGE 440
            TP  A +  GIIA        +  LV+  S    L Y L  + ++++R+       T +
Sbjct: 349 LTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF-------TRK 401

Query: 441 EVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLL 488
           E+E   +        +TL  +F  L  I +  + + +Y    +L+ LL
Sbjct: 402 ELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLL 449


>gi|7657591 solute carrier family 7, member 9 [Homo sapiens]
          Length = 487

 Score =  103 bits (256), Expect = 6e-22
 Identities = 100/468 (21%), Positives = 199/468 (42%), Gaps = 47/468 (10%)

Query: 26  TRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAK--DKAGPSIVICFLVAALSSVLAGLC 83
           T L + L  +  +++ VG+ +G+G++V    V    +  GP ++I      L++ L  LC
Sbjct: 24  TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLAT-LGALC 82

Query: 84  YAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNH 143
           +AE G  + +SG  Y Y     G + A+   W  ++  VI   S A    S  + +    
Sbjct: 83  FAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLI--VIKPTSFAIICLSFSEYVCAPF 140

Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203
                   +    P ++ +     A   +L ++ + +L     + V  +FT   L+++  
Sbjct: 141 Y-------VGCKPPQIVVKC---LAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAI 190

Query: 204 VMISGFV---KGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATC 260
           ++ISG V   +G+  N+  + E  +L++  ++  +  G                      
Sbjct: 191 IIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNG---------------------- 228

Query: 261 FYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESP 320
            +A+ G++ +    EE +NP R++P+ I+I + +    Y  ++ +   +M   +L     
Sbjct: 229 LWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQA 288

Query: 321 LPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGT 380
           +   F      PA ++V +    +   +  G+ F   R+IY    +G + +VL+ I    
Sbjct: 289 VAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRR 348

Query: 381 RTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGE 440
            TP  A +  GIIA        +  LV+  S    L Y L  + ++++R+       T +
Sbjct: 349 LTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF-------TRK 401

Query: 441 EVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLL 488
           E+E   +        +TL  +F  L  I +  + + +Y    +L+ LL
Sbjct: 402 ELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLL 449


>gi|7657683 solute carrier family 7, (cationic amino acid
           transporter, y+ system) member 11 [Homo sapiens]
          Length = 501

 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 98/421 (23%), Positives = 182/421 (43%), Gaps = 47/421 (11%)

Query: 22  GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKD--KAGPSIVICFLVAALSSVL 79
           G  + +L R ++ L  V++ +G+ +GAG+++    V ++    G S+ I + V  + S+ 
Sbjct: 34  GQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTI-WTVCGVLSLF 92

Query: 80  AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGW-NLILSYVIGTASVARAWSSAFDN 138
             L YAE G  + +SG  Y Y     G L AF   W  L++     TA ++ A+      
Sbjct: 93  GALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAF------ 146

Query: 139 LIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNL 198
             G +I +     I   +P +  +      + +V++L    ++  S SA +    T   L
Sbjct: 147 --GRYILEPF--FIQCEIPELAIKLITAVGITVVMVLN---SMSVSWSARIQIFLTFCKL 199

Query: 199 LVLGFVMISG---FVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILR 255
             +  +++ G    +KG   N+K      + ++  L   +  G                 
Sbjct: 200 TAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYG----------------- 242

Query: 256 GAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQL 315
                 YA+ G+  +    EE +NP+++IP+ I IS+++  + Y   + A    +   +L
Sbjct: 243 -----MYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEEL 297

Query: 316 QPESPLPEAFLYIGWAPARYVVAVGSLCALST--SLLGSMFPMPRVIYAMAEDGLLFRVL 373
              + +  A  +       + +AV    ALS   S+ G +F + R+ Y  + +G L  +L
Sbjct: 298 LLSNAV--AVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEIL 355

Query: 374 ARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ-P 432
           + IH    TP+ A +V   +   M F   L  L++ +S    L   L    ++ LRY+ P
Sbjct: 356 SMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCP 415

Query: 433 D 433
           D
Sbjct: 416 D 416


>gi|186910308 solute carrier family 7 member 7 [Homo sapiens]
          Length = 511

 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 99/427 (23%), Positives = 172/427 (40%), Gaps = 57/427 (13%)

Query: 22  GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVL 79
           G  + +L + +S L+ V L VG+ +G+G++V    V    A  G S+VI + V  L SV 
Sbjct: 27  GPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVF 85

Query: 80  AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNL 139
             LCYAE G  + +SG++Y Y     G   AF   W  +L  +I   S A          
Sbjct: 86  GALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-----IIAIT 138

Query: 140 IGNHISKTLQGSIALHVPHVLAEY--PDFFALGLVLLLTGLLALGASESALVTKVFTGVN 197
             N++ + L        P   A Y      A   + LLT +         LV  +FT   
Sbjct: 139 FANYMVQPL-------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAK 191

Query: 198 LLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPF--GFEG--- 252
           +L L  V+++G V+                            LG G    F   FEG   
Sbjct: 192 VLALIAVIVAGIVR----------------------------LGQGASTHFENSFEGSSF 223

Query: 253 ----ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTL 308
               I     +  +++ G+D +    EE +NP+R++P+ I IS+ +  + Y   + A   
Sbjct: 224 AVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYT 283

Query: 309 MMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL 368
           ++    +     +   F    +    +++ +    +    L  S+    R+ +  + +G 
Sbjct: 284 VLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGH 343

Query: 369 LFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLIL 428
           L   +  IH    TP+ + + +GI+A     +  +  L++  S        L  +  L L
Sbjct: 344 LPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYL 403

Query: 429 RY-QPDQ 434
           R+ +PD+
Sbjct: 404 RWKEPDR 410


>gi|186910306 solute carrier family 7 member 7 [Homo sapiens]
          Length = 511

 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 99/427 (23%), Positives = 172/427 (40%), Gaps = 57/427 (13%)

Query: 22  GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVL 79
           G  + +L + +S L+ V L VG+ +G+G++V    V    A  G S+VI + V  L SV 
Sbjct: 27  GPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVF 85

Query: 80  AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNL 139
             LCYAE G  + +SG++Y Y     G   AF   W  +L  +I   S A          
Sbjct: 86  GALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-----IIAIT 138

Query: 140 IGNHISKTLQGSIALHVPHVLAEY--PDFFALGLVLLLTGLLALGASESALVTKVFTGVN 197
             N++ + L        P   A Y      A   + LLT +         LV  +FT   
Sbjct: 139 FANYMVQPL-------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAK 191

Query: 198 LLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPF--GFEG--- 252
           +L L  V+++G V+                            LG G    F   FEG   
Sbjct: 192 VLALIAVIVAGIVR----------------------------LGQGASTHFENSFEGSSF 223

Query: 253 ----ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTL 308
               I     +  +++ G+D +    EE +NP+R++P+ I IS+ +  + Y   + A   
Sbjct: 224 AVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYT 283

Query: 309 MMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL 368
           ++    +     +   F    +    +++ +    +    L  S+    R+ +  + +G 
Sbjct: 284 VLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGH 343

Query: 369 LFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLIL 428
           L   +  IH    TP+ + + +GI+A     +  +  L++  S        L  +  L L
Sbjct: 344 LPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYL 403

Query: 429 RY-QPDQ 434
           R+ +PD+
Sbjct: 404 RWKEPDR 410


>gi|186910304 solute carrier family 7 member 7 [Homo sapiens]
          Length = 511

 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 99/427 (23%), Positives = 172/427 (40%), Gaps = 57/427 (13%)

Query: 22  GMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVL 79
           G  + +L + +S L+ V L VG+ +G+G++V    V    A  G S+VI + V  L SV 
Sbjct: 27  GPEQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVF 85

Query: 80  AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNL 139
             LCYAE G  + +SG++Y Y     G   AF   W  +L  +I   S A          
Sbjct: 86  GALCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-----IIAIT 138

Query: 140 IGNHISKTLQGSIALHVPHVLAEY--PDFFALGLVLLLTGLLALGASESALVTKVFTGVN 197
             N++ + L        P   A Y      A   + LLT +         LV  +FT   
Sbjct: 139 FANYMVQPL-------FPSCFAPYAASRLLAAACICLLTFINCAYVKWGTLVQDIFTYAK 191

Query: 198 LLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPF--GFEG--- 252
           +L L  V+++G V+                            LG G    F   FEG   
Sbjct: 192 VLALIAVIVAGIVR----------------------------LGQGASTHFENSFEGSSF 223

Query: 253 ----ILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTL 308
               I     +  +++ G+D +    EE +NP+R++P+ I IS+ +  + Y   + A   
Sbjct: 224 AVGDIALALYSALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYILTNVAYYT 283

Query: 309 MMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL 368
           ++    +     +   F    +    +++ +    +    L  S+    R+ +  + +G 
Sbjct: 284 VLDMRDILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAASRLFFVGSREGH 343

Query: 369 LFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLIL 428
           L   +  IH    TP+ + + +GI+A     +  +  L++  S        L  +  L L
Sbjct: 344 LPDAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYL 403

Query: 429 RY-QPDQ 434
           R+ +PD+
Sbjct: 404 RWKEPDR 410


>gi|33286428 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 8 isoform a [Homo
           sapiens]
          Length = 535

 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 111/517 (21%), Positives = 205/517 (39%), Gaps = 83/517 (16%)

Query: 21  SGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSI-VICFLVAALSSVL 79
           SG     L + +  +    + VG+ +G+G++V    V ++     + +I ++V    +V+
Sbjct: 29  SGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVV 88

Query: 80  AGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLIL-SYVIGTASVARAWSSAFDN 138
             LCYAE G  +P+SG  Y Y     G L  F   W  +L  Y    A +A  +S     
Sbjct: 89  GALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFS----- 143

Query: 139 LIGNHISKTLQGSIALHVPHVLAEYPDFFALGL-----VLLLTGLLALGASESALVTKVF 193
              N++ + L  +           +P    L L     +LLLT +       +  V  +F
Sbjct: 144 ---NYVLQPLFPTC----------FPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIF 190

Query: 194 TGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGI 253
           T   LL L  ++I G V       ++ + +Y     E  + +        G V   F   
Sbjct: 191 TAGKLLALALIIIMGIV-------QICKGEY--FWLEPKNAFENFQEPDIGLVALAF--- 238

Query: 254 LRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYY 313
           L+G+    +A+ G++ +    EE  +P +++P  I IS+ +    Y   + A    M   
Sbjct: 239 LQGS----FAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQ 294

Query: 314 QLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVL 373
           +L   + +   F         +++ +    +    + GS+F   R+ +A A +G L  VL
Sbjct: 295 ELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVL 354

Query: 374 ARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY-QP 432
           A IH    TPI A + + I    M     +  L++ +     L Y +     ++LR+ +P
Sbjct: 355 AMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKP 414

Query: 433 DQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALC 492
           D                                  IP P+   +++    ++ +L  A  
Sbjct: 415 D----------------------------------IPRPIKINLLF---PIIYLLFWAFL 437

Query: 493 LVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWR 529
           LV + WS P++ G      + ++L  + +  + V W+
Sbjct: 438 LVFSLWSEPVVCG----IGLAIMLTGVPVYFLGVYWQ 470


>gi|115648063 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 6 [Homo sapiens]
          Length = 515

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 92/408 (22%), Positives = 173/408 (42%), Gaps = 36/408 (8%)

Query: 27  RLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVLAGLCY 84
           +L + +S L+ V+L VG+ +G+G++V    V    A  G S+++ + +  L SV+  LCY
Sbjct: 40  QLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIV-WAIGGLFSVVGALCY 98

Query: 85  AEFGARVPRSGSAYLYSYVTVGELWAFTTGW-NLILSYVIGTASVARAWSSAFDNLIGNH 143
           AE G  + +SG++Y Y     G   AF   W +L++    G A +A      F N I   
Sbjct: 99  AELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIA----ITFANYI--- 151

Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203
               +Q S     P  LA      A   + LLT +          V   FT   ++ L  
Sbjct: 152 ----IQPSFPSCDPPYLA--CRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIA 205

Query: 204 VMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYA 263
           +++ G VK    + +  ++ +E        ++ +G L    +             +  ++
Sbjct: 206 IIVMGLVKLCQGHSEHFQDAFE------GSSWDMGNLSLALY-------------SALFS 246

Query: 264 FVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPE 323
           + G+D +    EE +NP+R++P+ I IS+ +  L Y   + A   ++    +     +  
Sbjct: 247 YSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAV 306

Query: 324 AFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTP 383
            F    +    + + +    +    L  S+F   R+ +  + +G L  +L+ IH    TP
Sbjct: 307 TFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTP 366

Query: 384 IIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431
           I A + +  +A     +  +  L++  S        L  +  L LR++
Sbjct: 367 IPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWK 414


>gi|115648022 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 6 [Homo sapiens]
          Length = 515

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 92/408 (22%), Positives = 173/408 (42%), Gaps = 36/408 (8%)

Query: 27  RLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKA--GPSIVICFLVAALSSVLAGLCY 84
           +L + +S L+ V+L VG+ +G+G++V    V    A  G S+++ + +  L SV+  LCY
Sbjct: 40  QLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIV-WAIGGLFSVVGALCY 98

Query: 85  AEFGARVPRSGSAYLYSYVTVGELWAFTTGW-NLILSYVIGTASVARAWSSAFDNLIGNH 143
           AE G  + +SG++Y Y     G   AF   W +L++    G A +A      F N I   
Sbjct: 99  AELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIA----ITFANYI--- 151

Query: 144 ISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGF 203
               +Q S     P  LA      A   + LLT +          V   FT   ++ L  
Sbjct: 152 ----IQPSFPSCDPPYLA--CRLLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVVALIA 205

Query: 204 VMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYA 263
           +++ G VK    + +  ++ +E        ++ +G L    +             +  ++
Sbjct: 206 IIVMGLVKLCQGHSEHFQDAFE------GSSWDMGNLSLALY-------------SALFS 246

Query: 264 FVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPE 323
           + G+D +    EE +NP+R++P+ I IS+ +  L Y   + A   ++    +     +  
Sbjct: 247 YSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLSSDAVAV 306

Query: 324 AFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTP 383
            F    +    + + +    +    L  S+F   R+ +  + +G L  +L+ IH    TP
Sbjct: 307 TFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIHIERFTP 366

Query: 384 IIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431
           I A + +  +A     +  +  L++  S        L  +  L LR++
Sbjct: 367 IPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWK 414


>gi|9790235 solute carrier family 7, member 10 [Homo sapiens]
          Length = 523

 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 94/420 (22%), Positives = 178/420 (42%), Gaps = 39/420 (9%)

Query: 18  TLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVI-CFLVAALS 76
           T+        L + +  L    + +G+ +G+G+++    V +      + +  +++    
Sbjct: 26  TVPGASERVALKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGV 85

Query: 77  SVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAF 136
           + L  LCYAE G  +P+SG  Y Y     G L  F   W+ +L  ++   S+A   S  F
Sbjct: 86  TALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVL--IMYPTSLA-VISMTF 142

Query: 137 DNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGV 196
            N +       LQ      +P   A      ++  ++LLT + +     +  +  +FTG 
Sbjct: 143 SNYV-------LQPVFPNCIPPTTAS--RVLSMACLMLLTWVNSSSVRWATRIQDMFTGG 193

Query: 197 NLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRG 256
            LL L  ++  G +       ++ +  +E      ++ ++     S G +   F   L+G
Sbjct: 194 KLLALSLIIGVGLL-------QIFQGHFE--ELRPSNAFAFWMTPSVGHLALAF---LQG 241

Query: 257 AATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLS-VCFLAYFAVSSALTLMMPYYQL 315
           +    +AF G++ +    EE  + ++++P  I IS+  V F+  F   +  T M P   L
Sbjct: 242 S----FAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELL 297

Query: 316 QPES---PLPEAFL-YIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFR 371
              +      E  L Y  W     V+ V    +    + G +F   R+ ++ A +G L  
Sbjct: 298 SSNAVAVTFGEKLLGYFSW-----VMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPS 352

Query: 372 VLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431
           +LA IH    TPI A +V     A +  +     L++ +S    L Y +  + +L+LR++
Sbjct: 353 LLAMIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWR 412


>gi|71999149 solute carrier family 7, (cationic amino acid
           transporter, y+ system) member 13 [Homo sapiens]
          Length = 470

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 94/399 (23%), Positives = 168/399 (42%), Gaps = 54/399 (13%)

Query: 46  LGAGVYVLA-GEVAKDKAGPSIVICFLVA-ALSSVLAGLCYAEFGARVPRSGSAYLYSYV 103
           +GAG++V   G +A       + +C     A+ ++ + LC AE     P SG+ Y +   
Sbjct: 27  IGAGIFVSPKGVLAYSCMNVGVSLCVWAGCAILAMTSTLCSAEISISFPCSGAQYYFLKR 86

Query: 104 TVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEY 163
             G   AF   W    S  +G+  VA     A   L+  +  +    S +  VP +  + 
Sbjct: 87  YFGSTVAFLNLWT---SLFLGSGVVA---GQAL--LLAEYSIQPFFPSCS--VPKLPKK- 135

Query: 164 PDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVMISG---FVKGDVHNWKLT 220
               AL ++ ++  L + G  E   +    + + + +L F+ ++G    ++G   N +  
Sbjct: 136 --CLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVERF 193

Query: 221 EEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNP 280
           +  ++   AEL D   L             + I +G    ++A+ G  C      E + P
Sbjct: 194 QNAFD---AELPDISHL------------IQAIFQG----YFAYSGGACFTLIAGELKKP 234

Query: 281 QRSIPMGIVISLSVCFLAYFAVS-SALTLMMPYYQLQPESP----LPEAFLYIGWAPARY 335
           + +IP  I  +L +  + Y  V+ S LT++ P   L  ++        AF  + W     
Sbjct: 235 RTTIPKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDAVAITWADRAFPSLAW----- 289

Query: 336 VVAVGSLCALSTSLLGSMFPMPRVIYAMAEDG---LLFRVLARIHTGTRTPIIATVVSGI 392
           ++      +L ++LL S+F   R IY  +++G   LLF  L   H+   T ++  V  G 
Sbjct: 290 IMPFAISTSLFSNLLISIFKSSRPIYLASQEGQLPLLFNTL-NSHSSPFTAVLLLVTLGS 348

Query: 393 IAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQ 431
           +A     L  L DL++ +     L   L+ I +L  RYQ
Sbjct: 349 LA---IILTSLIDLINYIFFTGSLWSILLMIGILRRRYQ 384



 Score = 31.2 bits (69), Expect = 3.0
 Identities = 29/100 (29%), Positives = 54/100 (54%), Gaps = 14/100 (14%)

Query: 461 LFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLI 520
           LF  LNS  +P +  ++ V    LA++LT+L  ++   +    +G  LW+      +LL+
Sbjct: 326 LFNTLNSHSSPFTAVLLLVTLGSLAIILTSLIDLI---NYIFFTGS-LWS------ILLM 375

Query: 521 IGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMM 560
           IGI+   +++P  S P  +KV      PL +I +++ L++
Sbjct: 376 IGILRRRYQEPNLSIP--YKV--FLSFPLATIVIDVGLVV 411


>gi|33286430 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 8 isoform b [Homo
           sapiens]
          Length = 332

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 54/269 (20%), Positives = 107/269 (39%), Gaps = 42/269 (15%)

Query: 262 YAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPL 321
           +A+ G++ +    EE  +P +++P  I IS+ +    Y   + A    M   +L   + +
Sbjct: 40  FAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAV 99

Query: 322 PEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTR 381
              F         +++ +    +    + GS+F   R+ +A A +G L  VLA IH    
Sbjct: 100 AVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRC 159

Query: 382 TPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY-QPDQETKTGE 440
           TPI A + + I    M     +  L++ +     L Y +     ++LR+ +PD       
Sbjct: 160 TPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPD------- 212

Query: 441 EVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSV 500
                                      IP P+   +++    ++ +L  A  LV + WS 
Sbjct: 213 ---------------------------IPRPIKINLLF---PIIYLLFWAFLLVFSLWSE 242

Query: 501 PLLSGDLLWTAVVVLLLLLIIGIIVVIWR 529
           P++ G      + ++L  + +  + V W+
Sbjct: 243 PVVCG----IGLAIMLTGVPVYFLGVYWQ 267


>gi|31881740 solute carrier family 12 (potassium/chloride
           transporters), member 9 [Homo sapiens]
          Length = 914

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 40/175 (22%), Positives = 75/175 (42%), Gaps = 7/175 (4%)

Query: 258 ATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQP 317
           A  F    G    A    E ++P R+IP+G +++++  F  Y  +    +       LQ 
Sbjct: 272 AVLFNGCTGIMAGANMSGELKDPSRAIPLGTIVAVAYTFFVYVLLFFLSSFTCDRTLLQE 331

Query: 318 ESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIH 377
           +     A     W P   +V +G      ++ + S+    R+++A+A D L   +LA   
Sbjct: 332 DYGFFRAISL--WPP---LVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAK 386

Query: 378 TGTR--TPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRY 430
             +R   P  A + S  +   +    KL  L  ++++  L+AY+ V +  L L +
Sbjct: 387 VVSRGGNPWAAVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEW 441


>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
          Length = 714

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 82/389 (21%), Positives = 156/389 (40%), Gaps = 47/389 (12%)

Query: 63  GPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYV 122
           G  +V   ++ AL +VL+G+   E  +     GS  +YS ++   +    TG  + L YV
Sbjct: 74  GMFLVSFVILVALVTVLSGIGVGERSS----IGSGGVYSMIS--SVLGGQTGGTIGLLYV 127

Query: 123 IGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALG 182
            G       + + F   I +                 L    + +A+  + +   L  LG
Sbjct: 128 FGQCVAGAMYITGFAESISD-----------------LLGLGNIWAVRGISVAVLLALLG 170

Query: 183 ASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGS 242
            + + +   +   + LL L  V    FV G   +    E  +     EL    +L P  S
Sbjct: 171 INLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLD-PEHGFIGYSPELLQNNTL-PDYS 228

Query: 243 GGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAV 302
            G   F   G+   AAT   A  GF+     G + + P  SIP+G + ++ + +  Y   
Sbjct: 229 PGESFFTVFGVFFPAATGVMA--GFNM----GGDLREPAASIPLGSLAAVGISWFLYIVF 282

Query: 303 SSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYA 362
              L  +     L+ +  + E    +G     ++  +G   +   S +G ++  PR++  
Sbjct: 283 VFLLGAICTREALRYDFLIAEKVSLMG-----FLFLLGLYISSLASCMGGLYGAPRILQC 337

Query: 363 MAEDGLLFRVLARIHTG---TRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYS 419
           +A++ ++   LA +  G    +TP+ A  ++ ++     F+ ++  L  +++I  +L Y 
Sbjct: 338 IAQEKVI-PALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYV 396

Query: 420 LV-------SICVLILRYQPDQETKTGEE 441
            V       S+C   L   P+   + G E
Sbjct: 397 AVDYSYFSLSMCSCSLTPVPEPVLREGAE 425


>gi|225579067 solute carrier family 12, member 4 isoform e [Homo
           sapiens]
          Length = 1054

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)

Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
           ++   AT F   VG    + TG  A        ++ Q+SIP+G ++++    L YF+   
Sbjct: 381 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 440

Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
                +    L+ +        L +G   W P+ +V+ +GS  +   + L S+   PR++
Sbjct: 441 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 499

Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
            A+A+D ++   RV          P  A +++ +IA     +  L  +  ++S+  L+ Y
Sbjct: 500 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 558

Query: 419 SLVSICVLI 427
             V++   +
Sbjct: 559 LFVNLACAV 567


>gi|225579065 solute carrier family 12, member 4 isoform d [Homo
           sapiens]
          Length = 1079

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)

Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
           ++   AT F   VG    + TG  A        ++ Q+SIP+G ++++    L YF+   
Sbjct: 406 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 465

Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
                +    L+ +        L +G   W P+ +V+ +GS  +   + L S+   PR++
Sbjct: 466 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 524

Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
            A+A+D ++   RV          P  A +++ +IA     +  L  +  ++S+  L+ Y
Sbjct: 525 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 583

Query: 419 SLVSICVLI 427
             V++   +
Sbjct: 584 LFVNLACAV 592


>gi|225579063 solute carrier family 12, member 4 isoform c [Homo
           sapiens]
          Length = 1087

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)

Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
           ++   AT F   VG    + TG  A        ++ Q+SIP+G ++++    L YF+   
Sbjct: 414 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 473

Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
                +    L+ +        L +G   W P+ +V+ +GS  +   + L S+   PR++
Sbjct: 474 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 532

Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
            A+A+D ++   RV          P  A +++ +IA     +  L  +  ++S+  L+ Y
Sbjct: 533 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 591

Query: 419 SLVSICVLI 427
             V++   +
Sbjct: 592 LFVNLACAV 600


>gi|225579061 solute carrier family 12, member 4 isoform b [Homo
           sapiens]
          Length = 1079

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)

Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
           ++   AT F   VG    + TG  A        ++ Q+SIP+G ++++    L YF+   
Sbjct: 412 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 471

Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
                +    L+ +        L +G   W P+ +V+ +GS  +   + L S+   PR++
Sbjct: 472 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 530

Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
            A+A+D ++   RV          P  A +++ +IA     +  L  +  ++S+  L+ Y
Sbjct: 531 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 589

Query: 419 SLVSICVLI 427
             V++   +
Sbjct: 590 LFVNLACAV 598


>gi|4827006 solute carrier family 12, member 4 isoform a [Homo
           sapiens]
          Length = 1085

 Score = 39.3 bits (90), Expect = 0.011
 Identities = 42/189 (22%), Positives = 84/189 (44%), Gaps = 16/189 (8%)

Query: 253 ILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSIPMGIVISLSVCFLAYFAVSS 304
           ++   AT F   VG    + TG  A        ++ Q+SIP+G ++++    L YF+   
Sbjct: 412 VVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLVYFSSVV 471

Query: 305 ALTLMMPYYQLQPE-SPLPEAFLYIG---WAPARYVVAVGSLCALSTSLLGSMFPMPRVI 360
                +    L+ +        L +G   W P+ +V+ +GS  +   + L S+   PR++
Sbjct: 472 LFGACIEGVVLRDKYGDGVSRNLVVGTLAW-PSPWVIVIGSFFSTCGAGLQSLTGAPRLL 530

Query: 361 YAMAEDGLL--FRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAY 418
            A+A+D ++   RV          P  A +++ +IA     +  L  +  ++S+  L+ Y
Sbjct: 531 QAIAKDNIIPFLRVFGHGKVNGE-PTWALLLTALIAELGILIASLDMVAPILSMFFLMCY 589

Query: 419 SLVSICVLI 427
             V++   +
Sbjct: 590 LFVNLACAV 598


>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
           sapiens]
          Length = 1099

 Score = 37.7 bits (86), Expect = 0.032
 Identities = 56/288 (19%), Positives = 114/288 (39%), Gaps = 51/288 (17%)

Query: 175 LTGLLALGASESALVTKVFTGVNLLVLGFVMISGFVKGDV---HNWKLTEEDYELAMAEL 231
           +T ++ LG S + +  +    V LLV+  + I+ F  G V   +N K +   +    +  
Sbjct: 307 ITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIF 366

Query: 232 NDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVIS 291
            + +  GP  + G      EG     A  F A  G    A    + ++PQ +IP G +++
Sbjct: 367 AENF--GPRFTKG------EGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLA 418

Query: 292 LSVCFLAYFAV----------------------------SSALTLMMPYYQLQPE----- 318
           + +  +AY  V                            S+A  L   + + + E     
Sbjct: 419 IFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFSRCRHEPCQYG 478

Query: 319 --SPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGL--LFRVLA 374
             +      +  G+ P   ++  G   A  +S L S+   P+V  A+ +D +    +  A
Sbjct: 479 LMNNFQVMSMVSGFGP---LITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA 535

Query: 375 RIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVS 422
           + +     P+   +++ +IA     + +L  +  ++S   L +Y+L++
Sbjct: 536 KGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALIN 583


>gi|198041678 solute carrier family 12 (potassium-chloride
           transporter), member 5 isoform 1 [Homo sapiens]
          Length = 1139

 Score = 36.6 bits (83), Expect = 0.070
 Identities = 56/270 (20%), Positives = 112/270 (41%), Gaps = 25/270 (9%)

Query: 175 LTGLLALGASESALVTKVFTGVNLLVLGFV--MISGFVKGDVHNWKLTEEDYELAMAELN 232
           L GL       +A   + FT  N+  +  +    SG +K ++ +  LT+      + E +
Sbjct: 340 LWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKG----VIVERS 395

Query: 233 DTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSI 284
              S+G L  G  +      +     + F   VG    + TG  A        ++ Q+SI
Sbjct: 396 GMTSVG-LADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSI 454

Query: 285 PMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAF---LYIG---WAPARYVVA 338
           P G +++++     Y  +SS +        +       EA    L +G   W P+ +V+ 
Sbjct: 455 PTGTILAIATTSAVY--ISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAW-PSPWVIV 511

Query: 339 VGSLCALSTSLLGSMFPMPRVIYAMAEDGLL-FRVLARIHTGTRTPIIATVVSGIIAAFM 397
           +GS  +   + L S+   PR++ A++ DG++ F  +         P  A +++  I    
Sbjct: 512 IGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIG 571

Query: 398 AFLFKLTDLVDLMSIGTLLAYSLVSICVLI 427
             +  L ++  ++S+  L+ Y  V++   +
Sbjct: 572 ILIASLDEVAPILSMFFLMCYMFVNLACAV 601


>gi|11968148 solute carrier family 12 (potassium-chloride
           transporter), member 5 isoform 2 [Homo sapiens]
          Length = 1116

 Score = 36.6 bits (83), Expect = 0.070
 Identities = 56/270 (20%), Positives = 112/270 (41%), Gaps = 25/270 (9%)

Query: 175 LTGLLALGASESALVTKVFTGVNLLVLGFV--MISGFVKGDVHNWKLTEEDYELAMAELN 232
           L GL       +A   + FT  N+  +  +    SG +K ++ +  LT+      + E +
Sbjct: 317 LWGLFCSSRFLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKG----VIVERS 372

Query: 233 DTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEA--------QNPQRSI 284
              S+G L  G  +      +     + F   VG    + TG  A        ++ Q+SI
Sbjct: 373 GMTSVG-LADGTPIDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSI 431

Query: 285 PMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAF---LYIG---WAPARYVVA 338
           P G +++++     Y  +SS +        +       EA    L +G   W P+ +V+ 
Sbjct: 432 PTGTILAIATTSAVY--ISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAW-PSPWVIV 488

Query: 339 VGSLCALSTSLLGSMFPMPRVIYAMAEDGLL-FRVLARIHTGTRTPIIATVVSGIIAAFM 397
           +GS  +   + L S+   PR++ A++ DG++ F  +         P  A +++  I    
Sbjct: 489 IGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIG 548

Query: 398 AFLFKLTDLVDLMSIGTLLAYSLVSICVLI 427
             +  L ++  ++S+  L+ Y  V++   +
Sbjct: 549 ILIASLDEVAPILSMFFLMCYMFVNLACAV 578


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.325    0.140    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,824,446
Number of Sequences: 37866
Number of extensions: 934559
Number of successful extensions: 3410
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 3307
Number of HSP's gapped (non-prelim): 65
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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