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Search of human proteins with 22027541
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22027541 programmed cell death 7 [Homo sapiens]
(485 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22027541 programmed cell death 7 [Homo sapiens] 999 0.0
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ... 88 2e-17
gi|160707881 formin 2 [Homo sapiens] 87 3e-17
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 83 5e-16
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens] 83 5e-16
gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo sap... 75 1e-13
gi|11386183 WAS protein family, member 2 [Homo sapiens] 74 3e-13
gi|7706501 WW domain binding protein 11 [Homo sapiens] 74 3e-13
gi|33356148 formin-like 1 [Homo sapiens] 73 5e-13
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens] 73 7e-13
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin... 73 7e-13
gi|153792074 proline rich 12 [Homo sapiens] 73 7e-13
gi|157168329 formin 1 [Homo sapiens] 72 9e-13
gi|149999378 inverted formin 2 isoform 2 [Homo sapiens] 72 1e-12
gi|149999380 inverted formin 2 isoform 1 [Homo sapiens] 72 1e-12
gi|150417989 cyclin K isoform 1 [Homo sapiens] 72 1e-12
gi|18959210 WIRE protein [Homo sapiens] 72 1e-12
gi|47132519 Ras association and pleckstrin homology domains 1 is... 71 2e-12
gi|21389357 MAPK-interacting and spindle-stabilizing protein [Ho... 70 3e-12
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens] 70 6e-12
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 69 7e-12
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 69 7e-12
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 69 7e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 69 7e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 69 7e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 69 7e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 69 7e-12
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 69 7e-12
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 69 7e-12
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 69 7e-12
>gi|22027541 programmed cell death 7 [Homo sapiens]
Length = 485
Score = 999 bits (2584), Expect = 0.0
Identities = 485/485 (100%), Positives = 485/485 (100%)
Query: 1 MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPL 60
MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPL
Sbjct: 1 MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPL 60
Query: 61 ALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSP 120
ALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSP
Sbjct: 61 ALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSP 120
Query: 121 RWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGEVRARLLR 180
RWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGEVRARLLR
Sbjct: 121 RWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGEVRARLLR 180
Query: 181 ALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRRLE 240
ALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRRLE
Sbjct: 181 ALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRRLE 240
Query: 241 RVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADG 300
RVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADG
Sbjct: 241 RVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADG 300
Query: 301 VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK 360
VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK
Sbjct: 301 VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK 360
Query: 361 KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESKLFGDPDEFPL 420
KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESKLFGDPDEFPL
Sbjct: 361 KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESKLFGDPDEFPL 420
Query: 421 AHLLEPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGNFVPQGWVLPPLPSNDIWAT 480
AHLLEPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGNFVPQGWVLPPLPSNDIWAT
Sbjct: 421 AHLLEPFRQYYLQAEHSLPALIQIRHDWDQYLVPSDHPKGNFVPQGWVLPPLPSNDIWAT 480
Query: 481 AVKLH 485
AVKLH
Sbjct: 481 AVKLH 485
>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
subunit [Homo sapiens]
Length = 551
Score = 87.8 bits (216), Expect = 2e-17
Identities = 92/300 (30%), Positives = 118/300 (39%), Gaps = 65/300 (21%)
Query: 7 FGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRA 66
FGQ GP PP PPPP P PPP P P PP P PGPFP L PPL L P
Sbjct: 284 FGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPP--PGPFPPRPPGPLGPPLTLAP-- 339
Query: 67 SAEASRGGGGAGAFYPVPPPPLPPPPPQCRPF---PGTDAGERPRPPPPGPGPPWSPRWP 123
P PPP PPP P P P T++G P GPP P P
Sbjct: 340 -----------PPHLPGPPPGAPPPAPHVNPAFFPPPTNSG---MPTSDSRGPP--PTDP 383
Query: 124 EAPPPPADVLG--------DAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGEVR 175
PPP D D A L + ++ E + R R + S G+
Sbjct: 384 YGRPPPYDRGDYGPPGREMDTARTPLSEAEF-EEIMNRNRAISSSAISRAVSDASAGDYG 442
Query: 176 A---RLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYV 232
+ L+ A+ L+++ + AD VL+ S L + L + +Y
Sbjct: 443 SAIETLVTAISLIKQ--------SKVSADDRCKVLISS--------LQDCLHGIESKSYG 486
Query: 233 GEARRR----------LERVRRRRLRLRER----AREREAEREAEAARAVEREQEIDRWR 278
+RR E+ RR + R R+R RER ERE R +R++E DR R
Sbjct: 487 SGSRRERSRERDHSRSREKSRRHKSRSRDRHDDYYRERSRERERHRDRDRDRDRERDRER 546
Score = 35.4 bits (80), Expect = 0.12
Identities = 24/74 (32%), Positives = 28/74 (37%), Gaps = 13/74 (17%)
Query: 1 MALPPFFGQGRPGPPPPQP-------PPPAPFGCP------PPPLPSPAFPPPLPQRPGP 47
+A PP PG PPP P PPP G P PPP PPP +
Sbjct: 337 LAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYG 396
Query: 48 FPGASAPFLQPPLA 61
PG + PL+
Sbjct: 397 PPGREMDTARTPLS 410
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 87.0 bits (214), Expect = 3e-17
Identities = 67/148 (45%), Positives = 68/148 (45%), Gaps = 31/148 (20%)
Query: 1 MALPPFFGQGRPGPPP------PQPPPPAPFGCP-PPPLPSPAFPPPLP------QRPGP 47
+ LPP G G P PPP P PPP G P PPPLP PPP P P P
Sbjct: 932 LPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPP 991
Query: 48 FPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFPGTDA 103
PGA P PP L P A GAG PPPPLP PPPP P PG A
Sbjct: 992 LPGAGIP---PPPPL-PGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPP---PLPG--A 1039
Query: 104 GERPRPPPPGPGPPWSPRWPEA--PPPP 129
G P PP PG G P P P A PPPP
Sbjct: 1040 GIPPPPPLPGAGIPPPPPLPGAGIPPPP 1067
Score = 86.3 bits (212), Expect = 6e-17
Identities = 65/139 (46%), Positives = 65/139 (46%), Gaps = 30/139 (21%)
Query: 4 PPFFGQGRPGPPP-------PQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFL 56
PP G G P PPP P PP P PPPPLP A PPP P PGA P L
Sbjct: 913 PPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPP-----PPLPGAGIP-L 966
Query: 57 QPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFPGTDAGERPRPPPP 112
PPL P A GAG PPPPLP PPPP P PG AG P PP P
Sbjct: 967 PPPL---PGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPP---PLPG--AGIPPPPPLP 1015
Query: 113 GPGPPWSPRWPEA--PPPP 129
G G P P P A PPPP
Sbjct: 1016 GAGIPPPPPLPGAGIPPPP 1034
Score = 85.5 bits (210), Expect = 1e-16
Identities = 67/151 (44%), Positives = 68/151 (45%), Gaps = 32/151 (21%)
Query: 4 PPFFGQGRPGPPPPQ-----PPPPAPFGC--PPPPLPSPAFPPPLP------QRPGPFPG 50
PP G G P PPP PPPP P PPPPLP PPP P P P PG
Sbjct: 968 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1027
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFPGTDAGER 106
A P PP L P A GAG PPPPLP PPPP P PG AG
Sbjct: 1028 AGIP---PPPPL-PGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPP---PLPG--AGIP 1075
Query: 107 PRPPPPGPGPPWSPRWPEA---PPPPADVLG 134
P PP PG G P P P A PPPP +G
Sbjct: 1076 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGVG 1106
Score = 84.7 bits (208), Expect = 2e-16
Identities = 66/145 (45%), Positives = 66/145 (45%), Gaps = 31/145 (21%)
Query: 4 PPFFGQGRPGPPPPQ-----PPPPAPFGC--PPPPLPSPAFPPPLP------QRPGPFPG 50
PP G G P PPP PPPP P PPPPLP PPP P P P PG
Sbjct: 990 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1049
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFPGTDAGER 106
A P PP L P A GAG PPPPLP PPPP P PG AG
Sbjct: 1050 AGIP---PPPPL-PGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPP---PLPG--AGIP 1097
Query: 107 PRPPPPGPGPPWSPRWPEA--PPPP 129
P PP PG G P P P A PPPP
Sbjct: 1098 PPPPLPGVGIPPPPPLPGAGIPPPP 1122
Score = 84.3 bits (207), Expect = 2e-16
Identities = 66/145 (45%), Positives = 66/145 (45%), Gaps = 31/145 (21%)
Query: 4 PPFFGQGRPGPPPPQ-----PPPPAPFGC--PPPPLPSPAFPPPLP------QRPGPFPG 50
PP G G P PPP PPPP P PPPPLP PPP P P P PG
Sbjct: 957 PPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1016
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFPGTDAGER 106
A P PP L P A GAG PPPPLP PPPP P PG AG
Sbjct: 1017 AGIP---PPPPL-PGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPP---PLPG--AGIP 1064
Query: 107 PRPPPPGPGPPWSPRWPEA--PPPP 129
P PP PG G P P P A PPPP
Sbjct: 1065 PPPPLPGAGIPPPPPLPGAGIPPPP 1089
Score = 83.6 bits (205), Expect = 4e-16
Identities = 65/145 (44%), Positives = 65/145 (44%), Gaps = 31/145 (21%)
Query: 4 PPFFGQGRPGPPPPQ-----PPPPAPFGC--PPPPLPSPAFPPPLP------QRPGPFPG 50
PP G G P PPP PPPP P PPPPLP PPP P P P PG
Sbjct: 979 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1038
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFPGTDAGER 106
A P PP L P A GAG PPPPLP PPPP P PG AG
Sbjct: 1039 AGIP---PPPPL-PGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPP---PLPG--AGIP 1086
Query: 107 PRPPPPGPGPPWSPRWPEA--PPPP 129
P PP PG G P P P PPPP
Sbjct: 1087 PPPPLPGAGIPPPPPLPGVGIPPPP 1111
Score = 83.6 bits (205), Expect = 4e-16
Identities = 65/145 (44%), Positives = 65/145 (44%), Gaps = 31/145 (21%)
Query: 4 PPFFGQGRPGPPPPQ-----PPPPAPFGC--PPPPLPSPAFPPPLP------QRPGPFPG 50
PP G G P PPP PPPP P PPPPLP PPP P P P PG
Sbjct: 1001 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1060
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFPGTDAGER 106
A P PP L P A GAG PPPPLP PPPP P PG G
Sbjct: 1061 AGIP---PPPPL-PGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPP---PLPGV--GIP 1108
Query: 107 PRPPPPGPGPPWSPRWPEA--PPPP 129
P PP PG G P P P A PPPP
Sbjct: 1109 PPPPLPGAGIPPPPPLPGAGIPPPP 1133
Score = 83.2 bits (204), Expect = 5e-16
Identities = 65/146 (44%), Positives = 65/146 (44%), Gaps = 32/146 (21%)
Query: 4 PPFFGQGRPGPPPPQ-----PPPPAPFGC--PPPPLPSPAFPPPLP------QRPGPFPG 50
PP G G P PPP PPPP P PPPPLP PPP P P P PG
Sbjct: 1023 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1082
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFPGTDAGER 106
A P PP L P A G G PPPPLP PPPP P PG AG
Sbjct: 1083 AGIP---PPPPL-PGAGIPPPPPLPGVGI---PPPPPLPGAGIPPPP---PLPG--AGIP 1130
Query: 107 PRPPPPG---PGPPWSPRWPEAPPPP 129
P PP PG P PP PR PPPP
Sbjct: 1131 PPPPLPGAGIPPPPPLPRVGIPPPPP 1156
Score = 80.5 bits (197), Expect = 3e-15
Identities = 62/154 (40%), Positives = 65/154 (42%), Gaps = 29/154 (18%)
Query: 4 PPFFGQGRPGPPPPQ-----PPPPAPFGC--PPPPLPSPAFPPPLP------QRPGPFPG 50
PP G G P PPP PPPP P PPPPLP PPP P P P PG
Sbjct: 1111 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPG 1170
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFPGTDAGER 106
A P PP L P G G PPPPLP PPPP P PG
Sbjct: 1171 AGIP---PPPPL-PGVGIPPPPPLPGVGI---PPPPPLPGAGIPPPP---PLPGMGIPPA 1220
Query: 107 PRPP--PPGPGPPWSPRWPEAPPPPADVLGDAAL 138
P PP PPG G P P P + PP +G + L
Sbjct: 1221 PAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTL 1254
Score = 72.0 bits (175), Expect = 1e-12
Identities = 56/147 (38%), Positives = 58/147 (39%), Gaps = 23/147 (15%)
Query: 4 PPFFGQGRPGPPP------PQPPPPAPFGCPPPP-LPSPAFPPPLP------QRPGPFPG 50
PP G G P PPP P PPP G PPPP LP PPP P P P PG
Sbjct: 1122 PPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPG 1181
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPP---PPPQCRPFPGTDAGERP 107
P PP L P GAG PPPPLP PP P P G P
Sbjct: 1182 VGIP---PPPPL-PGVGIPPPPPLPGAGI---PPPPPLPGMGIPPAPAPPLPPPGTGIPP 1234
Query: 108 RPPPPGPGPPWSPRWPEAPPPPADVLG 134
P P GPP P+ + P V G
Sbjct: 1235 PPLLPVSGPPLLPQVGSSTLPTPQVCG 1261
Score = 71.2 bits (173), Expect = 2e-12
Identities = 63/157 (40%), Positives = 63/157 (40%), Gaps = 50/157 (31%)
Query: 12 PGPPP----------------PQPPPPAPFGCPPPPLPSPAFPPP--------LPQRPGP 47
P PPP P PPPP P G P LPS A P P LP P P
Sbjct: 856 PSPPPLPCTESSSSMPGLGMVPPPPPPLP-GMTVPTLPSTAIPQPPPLQGTEMLPPPPPP 914
Query: 48 FPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFPGTD- 102
PGA P PP L P A GAG PPPPLP PPPP P PG
Sbjct: 915 LPGAGIP---PPPPL-PGAGILPLPPLPGAGI---PPPPPLPGAAIPPPP---PLPGAGI 964
Query: 103 --------AGERPRPPPPGPGPPWSPRWPEA--PPPP 129
AG P PP PG G P P P A PPPP
Sbjct: 965 PLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1001
Score = 62.4 bits (150), Expect = 9e-10
Identities = 53/154 (34%), Positives = 55/154 (35%), Gaps = 49/154 (31%)
Query: 8 GQGRPGPPPPQP-----------------------PPPAPFGCPPPPLPSPAF---PPPL 41
GQG+PG PP P P P C P PPP
Sbjct: 821 GQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPP- 879
Query: 42 PQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRP 97
P P PG + P L QP P PPPPLP PPPP P
Sbjct: 880 ---PPPLPGMTVPTLPSTAIPQPPPLQGTE--------MLPPPPPPLPGAGIPPPP---P 925
Query: 98 FPGTDAGERPRPPPPGPGPPWSPRWPEA--PPPP 129
PG AG P PP PG G P P P A PPPP
Sbjct: 926 LPG--AGILPLPPLPGAGIPPPPPLPGAAIPPPP 957
Score = 58.5 bits (140), Expect = 1e-08
Identities = 46/123 (37%), Positives = 49/123 (39%), Gaps = 32/123 (26%)
Query: 4 PPFFGQGRPGPPP------PQPPPPAPFGCPPPP-LPSPAFPPPLPQRPGPFPGASAPFL 56
PP G G P PPP P PPP G PPPP LP PPP P P A AP L
Sbjct: 1166 PPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAPPL 1225
Query: 57 QPPLALQPRASAEASRGGGGAGAFYPVPPPP-LPPPPPQCRPFPGTDAGERPRP----PP 111
PP G G +PPPP LP P P G+ P+ PP
Sbjct: 1226 PPP----------------GTG----IPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPP 1265
Query: 112 PGP 114
P P
Sbjct: 1266 PLP 1268
Score = 42.7 bits (99), Expect = 7e-04
Identities = 44/136 (32%), Positives = 46/136 (33%), Gaps = 32/136 (23%)
Query: 18 QPPPPAPF---------GCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASA 68
QPPPP G PP S F S PP P
Sbjct: 809 QPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPP----PLPCT 864
Query: 69 EASRGGGGAGAFYPVPPPPLP------------PPPPQCRPFPGTDAGERPRPPPPGPGP 116
E+S G G P PPPPLP P PP P GT+ P PP PG G
Sbjct: 865 ESSSSMPGLG-MVPPPPPPLPGMTVPTLPSTAIPQPP---PLQGTEMLPPPPPPLPGAGI 920
Query: 117 PWSPRWPEA---PPPP 129
P P P A P PP
Sbjct: 921 PPPPPLPGAGILPLPP 936
Score = 36.2 bits (82), Expect = 0.069
Identities = 37/123 (30%), Positives = 43/123 (34%), Gaps = 14/123 (11%)
Query: 14 PPPPQPPPPAPFGCPPPPLPS-PAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASR 72
P PQ PP +P G P PS PA P P +S F P A+ R
Sbjct: 287 PREPQQPP-SPGGLPVSEAPSLPAAQPAAKDSP-----SSTAFPFPEAGPGEEAAGAPVR 340
Query: 73 GGGGA---GAFYPVPPPPLPPPPPQCRPFPGTDA----GERPRPPPPGPGPPWSPRWPEA 125
G G G P P + P G DA GE P GP P + P +
Sbjct: 341 GAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGS 400
Query: 126 PPP 128
P P
Sbjct: 401 PAP 403
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 83.2 bits (204), Expect = 5e-16
Identities = 59/146 (40%), Positives = 61/146 (41%), Gaps = 32/146 (21%)
Query: 12 PGPPPPQPPPPAPFGC---------------PPPPLPSPAF---PPPLPQ-----RPGPF 48
P PPPP PPPP P G PPPPL A PPPLP+ P
Sbjct: 601 PPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSL 660
Query: 49 PGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP-----PPPPQCRPFPGTDA 103
PG +A PPL R G AG P PPPPLP PPPP P PG
Sbjct: 661 PGGTAIPPPPPLPGSARIPPPPPPLPGSAGI--PPPPPPLPGEAGMPPPPP--PLPGGPG 716
Query: 104 GERPRPPPPGPGPPWSPRWPEAPPPP 129
P P P GPG P P PPPP
Sbjct: 717 IPPPPPFPGGPGIPPPPPGMGMPPPP 742
Score = 79.7 bits (195), Expect = 5e-15
Identities = 67/176 (38%), Positives = 75/176 (42%), Gaps = 50/176 (28%)
Query: 1 MALPPFFGQGRPGPPPPQ---------PPPPAPFGC--PPPPLPSPAFPPPLP-----QR 44
+ +PP P PP P PPPPAP PPPP P P PPPLP
Sbjct: 561 ITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISS 620
Query: 45 PGPFPGASAPFLQPPLA----LQP--------RASAEASRGGGGA---------GAFYPV 83
P PG +A PPL+ + P + +S GG A A P
Sbjct: 621 PPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPP 680
Query: 84 PPPPLP-----PPPPQCRPFPGTDAGERPRPPP-PG----PGPPWSPRWPEAPPPP 129
PPPPLP PPPP P PG +AG P PPP PG P PP P P PPPP
Sbjct: 681 PPPPLPGSAGIPPPPP--PLPG-EAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP 733
Score = 58.2 bits (139), Expect = 2e-08
Identities = 40/95 (42%), Positives = 42/95 (44%), Gaps = 26/95 (27%)
Query: 4 PPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPA-FPPPLPQRPGPFPGASAPFLQPPLAL 62
PP G R PPPP P A PPPPLP A PPP P PG PG P PP
Sbjct: 670 PPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGG-PGIPPP---PPFP- 724
Query: 63 QPRASAEASRGGGGAGAFYPVPPPP----LPPPPP 93
GG G +PPPP +PPPPP
Sbjct: 725 ------------GGPG----IPPPPPGMGMPPPPP 743
Score = 40.4 bits (93), Expect = 0.004
Identities = 29/65 (44%), Positives = 31/65 (47%), Gaps = 7/65 (10%)
Query: 1 MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPL 60
M PP G PG PPP P P P G PPPP P PPP P F +AP L P
Sbjct: 704 MPPPPPPLPGGPGIPPPPPFPGGP-GIPPPP-PGMGMPPP---PPFGFGVPAAPVL--PF 756
Query: 61 ALQPR 65
L P+
Sbjct: 757 GLTPK 761
Score = 37.4 bits (85), Expect = 0.031
Identities = 20/53 (37%), Positives = 20/53 (37%)
Query: 77 AGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPP 129
A A P P P P P PG P PP PG P P PPPP
Sbjct: 558 AAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPP 610
>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
Length = 1272
Score = 83.2 bits (204), Expect = 5e-16
Identities = 59/146 (40%), Positives = 61/146 (41%), Gaps = 32/146 (21%)
Query: 12 PGPPPPQPPPPAPFGC---------------PPPPLPSPAF---PPPLPQ-----RPGPF 48
P PPPP PPPP P G PPPPL A PPPLP+ P
Sbjct: 610 PPPPPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSL 669
Query: 49 PGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP-----PPPPQCRPFPGTDA 103
PG +A PPL R G AG P PPPPLP PPPP P PG
Sbjct: 670 PGGTAIPPPPPLPGSARIPPPPPPLPGSAGI--PPPPPPLPGEAGMPPPPP--PLPGGPG 725
Query: 104 GERPRPPPPGPGPPWSPRWPEAPPPP 129
P P P GPG P P PPPP
Sbjct: 726 IPPPPPFPGGPGIPPPPPGMGMPPPP 751
Score = 79.7 bits (195), Expect = 5e-15
Identities = 67/176 (38%), Positives = 75/176 (42%), Gaps = 50/176 (28%)
Query: 1 MALPPFFGQGRPGPPPPQ---------PPPPAPFGC--PPPPLPSPAFPPPLP-----QR 44
+ +PP P PP P PPPPAP PPPP P P PPPLP
Sbjct: 570 ITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISS 629
Query: 45 PGPFPGASAPFLQPPLA----LQP--------RASAEASRGGGGA---------GAFYPV 83
P PG +A PPL+ + P + +S GG A A P
Sbjct: 630 PPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPP 689
Query: 84 PPPPLP-----PPPPQCRPFPGTDAGERPRPPP-PG----PGPPWSPRWPEAPPPP 129
PPPPLP PPPP P PG +AG P PPP PG P PP P P PPPP
Sbjct: 690 PPPPLPGSAGIPPPPP--PLPG-EAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP 742
Score = 58.2 bits (139), Expect = 2e-08
Identities = 40/95 (42%), Positives = 42/95 (44%), Gaps = 26/95 (27%)
Query: 4 PPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPA-FPPPLPQRPGPFPGASAPFLQPPLAL 62
PP G R PPPP P A PPPPLP A PPP P PG PG P PP
Sbjct: 679 PPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGG-PGIPPP---PPFP- 733
Query: 63 QPRASAEASRGGGGAGAFYPVPPPP----LPPPPP 93
GG G +PPPP +PPPPP
Sbjct: 734 ------------GGPG----IPPPPPGMGMPPPPP 752
Score = 40.4 bits (93), Expect = 0.004
Identities = 29/65 (44%), Positives = 31/65 (47%), Gaps = 7/65 (10%)
Query: 1 MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPL 60
M PP G PG PPP P P P G PPPP P PPP P F +AP L P
Sbjct: 713 MPPPPPPLPGGPGIPPPPPFPGGP-GIPPPP-PGMGMPPP---PPFGFGVPAAPVL--PF 765
Query: 61 ALQPR 65
L P+
Sbjct: 766 GLTPK 770
Score = 37.4 bits (85), Expect = 0.031
Identities = 20/53 (37%), Positives = 20/53 (37%)
Query: 77 AGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPP 129
A A P P P P P PG P PP PG P P PPPP
Sbjct: 567 AAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPP 619
>gi|51702526 Wiskott-Aldrich syndrome gene-like protein [Homo
sapiens]
Length = 505
Score = 75.5 bits (184), Expect = 1e-13
Identities = 61/180 (33%), Positives = 71/180 (39%), Gaps = 49/180 (27%)
Query: 4 PPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQ 63
PP R GPPPP PPPP G PPPP PPP P R P A+ P PP +
Sbjct: 277 PPPPPPSRGGPPPP-PPPPHNSGPPPPPARGRGAPPPPPSRA---PTAAPP---PPPPSR 329
Query: 64 PRASAEASRGGGGAGAFYPVPPPP---LPPPPPQCRPFPGTDAGERPRPPPP-------- 112
P + VPPPP + PPPP P + A P PPPP
Sbjct: 330 PSVA---------------VPPPPPNRMYPPPPPALP---SSAPSGPPPPPPSVLGVGPV 371
Query: 113 GPGPPWSPRWPEAPPPPADVLGD-------------AALQRLRDRQWLEAVFGTPRRAGC 159
P PP P P PPPP + D A L ++R+ L+ V R C
Sbjct: 372 APPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSC 431
>gi|11386183 WAS protein family, member 2 [Homo sapiens]
Length = 498
Score = 73.9 bits (180), Expect = 3e-13
Identities = 56/138 (40%), Positives = 60/138 (43%), Gaps = 34/138 (24%)
Query: 4 PPFFGQGRPGPPPPQPPPPAPFGCPPPPLP----SPAFPPPLPQRPG--PFPGASAPFLQ 57
PP G PP P PPPP G PPPP P SP PPP P P P P +AP
Sbjct: 309 PPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPP-PSPPSFPPHPDFAAPPPP 367
Query: 58 PPLALQPRASAEASRGGGGAGAFYP-VPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGP 116
PP P A A YP +PPPPL P P P P PPPPGP P
Sbjct: 368 PP----PPA------------ADYPTLPPPPLSQPTGGAPPPP-------PPPPPPGPPP 404
Query: 117 P---WSPRWPEAPPPPAD 131
P + P PPP +D
Sbjct: 405 PPFTGADGQPAIPPPLSD 422
Score = 67.4 bits (163), Expect = 3e-11
Identities = 61/208 (29%), Positives = 76/208 (36%), Gaps = 41/208 (19%)
Query: 8 GQGRPGPP------PPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLA 61
G G GP P PPP P G PP P P A PP P P P G P PP+
Sbjct: 283 GSGLAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPP--PPPV- 339
Query: 62 LQPRASAEASRGGGGAGAFYPVPPPPLPP-----PPPQCRPFPGTDAGERPRPP---PPG 113
G G G P PP PP PP P P D P PP P G
Sbjct: 340 -----------GFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTG 388
Query: 114 PGPPWSPRWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGE 173
PP P P PPP G + P + P+ + P++ +
Sbjct: 389 GAPPPPPPPPPPGPPPPPFTGADGQPAI-----------PPPLSDTTKPKSSL--PAVSD 435
Query: 174 VRARLLRALRLVRRLRGLSQALREAEAD 201
R+ LL A+R +LR + + + + D
Sbjct: 436 ARSDLLSAIRQGFQLRRVEEQREQEKRD 463
Score = 48.5 bits (114), Expect = 1e-05
Identities = 44/127 (34%), Positives = 50/127 (39%), Gaps = 11/127 (8%)
Query: 10 GRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPG---PFPGASAPFLQPPLALQPRA 66
G G PP GC + + ++PPP PQ P P S L PP A +
Sbjct: 220 GTSGYPPTLVYQNGSIGCVEN-VDASSYPPP-PQSDSASSPSPSFSEDNLPPPPA-EFSY 276
Query: 67 SAEASRGGGGAGAFYP-VPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEA 125
+ RG G AG V P PPP P PG G P P PP P PP
Sbjct: 277 PVDNQRGSGLAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIG----I 332
Query: 126 PPPPADV 132
PPPP V
Sbjct: 333 PPPPPPV 339
Score = 47.4 bits (111), Expect = 3e-05
Identities = 34/82 (41%), Positives = 40/82 (48%), Gaps = 16/82 (19%)
Query: 2 ALPPFFGQGRPGPPPPQP-------PPP---APFGCPPPPLPSPAFPPPLPQRPGPFPGA 51
+ PP P PPPP P PPP P G PPP P P PPP P P PF GA
Sbjct: 354 SFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPP--PPPGPP-PPPFTGA 410
Query: 52 SA-PFLQPPLA--LQPRASAEA 70
P + PPL+ +P++S A
Sbjct: 411 DGQPAIPPPLSDTTKPKSSLPA 432
>gi|7706501 WW domain binding protein 11 [Homo sapiens]
Length = 641
Score = 73.9 bits (180), Expect = 3e-13
Identities = 50/126 (39%), Positives = 53/126 (42%), Gaps = 28/126 (22%)
Query: 16 PPQPPPPAPFGCPPPPLPSPAFPPPLPQR----------PGPFPGASAPFLQPPLALQPR 65
PPQ PP+ PP P P P PPP P PGP PGA PFL+PP
Sbjct: 393 PPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAP-PFLRPP------ 445
Query: 66 ASAEASRGGGGAGAFYPVPP--PPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWP 123
G G P+P PP PPP P PG G P PPP GP P P P
Sbjct: 446 ---------GMPGLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAP 496
Query: 124 EAPPPP 129
PPP
Sbjct: 497 PGIPPP 502
Score = 69.3 bits (168), Expect = 7e-12
Identities = 65/206 (31%), Positives = 82/206 (39%), Gaps = 11/206 (5%)
Query: 4 PPFFGQGRPGPPPPQP--PPPAPFGCPP-PPLPSPAF--PPPLPQRPGPFPGASAPFLQP 58
PP G GPPP P PP P G PP PP +P F PP +P GP P P P
Sbjct: 405 PPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLPRLLPPGPPP 464
Query: 59 PLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPW 118
+P G G PPP LPPP P P P P PP GP PP
Sbjct: 465 G---RPPGPPPGPPPGLPPGPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGPAPP- 520
Query: 119 SPRWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGEVRARL 178
+P AP P VL R + + ++A + + E+ +
Sbjct: 521 -GLFPPAPLPNPGVLSAPPNLIQRPKADDTSAATIEKKATATISAKPQITNPKAEITRFV 579
Query: 179 LRALRLVRRLRGLSQA-LREAEADGA 203
ALR+ R +G + A R++E D A
Sbjct: 580 PTALRVRRENKGATAAPQRKSEDDSA 605
Score = 62.4 bits (150), Expect = 9e-10
Identities = 45/106 (42%), Positives = 45/106 (42%), Gaps = 22/106 (20%)
Query: 3 LPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQR-PGPFPGASAPFLQPPLA 61
LPP GRP PPP PPP P G PPP P P PPP P P P PG P L PPL
Sbjct: 458 LPPGPPPGRPPGPPPGPPPGLPPG-PPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLG 516
Query: 62 LQPRASAEASRGGGGAGAFYPVPPPPLPPP-----PPQCRPFPGTD 102
P G F PP PLP P PP P D
Sbjct: 517 PAP------------PGLF---PPAPLPNPGVLSAPPNLIQRPKAD 547
Score = 38.9 bits (89), Expect = 0.011
Identities = 24/61 (39%), Positives = 26/61 (42%), Gaps = 3/61 (4%)
Query: 71 SRGGGGAGAFYPVPPPPLPPPPPQCRPFPG-TDAGERPRPPPPGPGPPWSPRWPEAPPPP 129
S G A + PP +PP Q P PG G P PP PGPP P PPP
Sbjct: 380 SDGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTG--LPPGPPPG 437
Query: 130 A 130
A
Sbjct: 438 A 438
Score = 31.2 bits (69), Expect = 2.2
Identities = 13/30 (43%), Positives = 17/30 (56%)
Query: 1 MALPPFFGQGRPGPPPPQPPPPAPFGCPPP 30
+++ P G G P PP + PP P G PPP
Sbjct: 180 VSILPLLGHGVPRLPPGRKPPGPPPGPPPP 209
Score = 30.4 bits (67), Expect = 3.8
Identities = 29/89 (32%), Positives = 34/89 (38%), Gaps = 21/89 (23%)
Query: 31 PLPS-PAFPPPLPQRPGPFPGASAP-FLQPPLALQPRASAEASRGGGGAGAFYPVPPPPL 88
PLP P P + + P PGA P L+ A P A + G G P L
Sbjct: 140 PLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGV------PRL 193
Query: 89 PPPPPQCRPFPGTDAGERPRPPPPGPGPP 117
PP G +P PPPGP PP
Sbjct: 194 PP-------------GRKPPGPPPGPPPP 209
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 73.2 bits (178), Expect = 5e-13
Identities = 48/116 (41%), Positives = 49/116 (42%), Gaps = 26/116 (22%)
Query: 12 PGPPPPQPPP-------PAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQP 64
PG P P P PAP PPPP P P P P P SAP PPL P
Sbjct: 519 PGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPP------SAPPQAPPLPGSP 572
Query: 65 RASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSP 120
G +PPPP PPPPP PGTD G P PPPP P PP P
Sbjct: 573 EPPPAPPLPG-------DLPPPPPPPPPP-----PGTD-GPVPPPPPPPPPPPGGP 615
Score = 60.1 bits (144), Expect = 4e-09
Identities = 42/112 (37%), Positives = 43/112 (38%), Gaps = 43/112 (38%)
Query: 12 PGPPPPQPPPPAPFGCPP------PPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPR 65
P PPPP P P+P PP PPLP PPP P PG P P PP
Sbjct: 542 PPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPPPPPPP------ 595
Query: 66 ASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPP 117
G PVPPPP PPP PPPPG GPP
Sbjct: 596 ------------GTDGPVPPPP--PPP----------------PPPPG-GPP 616
Score = 49.7 bits (117), Expect = 6e-06
Identities = 35/100 (35%), Positives = 35/100 (35%), Gaps = 36/100 (36%)
Query: 4 PPFFGQGRPGPPPPQPPPPAP------FGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQ 57
PP G P PP PP AP P PPLP PPP P P P PG
Sbjct: 546 PPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPPPP--PPPPPGTDG---- 599
Query: 58 PPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRP 97
PVPPPP PPPPP P
Sbjct: 600 ------------------------PVPPPPPPPPPPPGGP 615
Score = 42.7 bits (99), Expect = 7e-04
Identities = 40/127 (31%), Positives = 48/127 (37%), Gaps = 28/127 (22%)
Query: 30 PPLPSPAFPPPLPQRPGPFP--------GASAPFLQPP---LALQPRASAEASRGGGGAG 78
PP P A PP P RP L+ P ++++ A A+ GG A
Sbjct: 459 PPEPEKA-PPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDA- 516
Query: 79 AFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPG-----------PPWSPRWPEAP- 126
P P P P P P G P PPPP PG PP +P P +P
Sbjct: 517 ---PTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPE 573
Query: 127 PPPADVL 133
PPPA L
Sbjct: 574 PPPAPPL 580
>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
Length = 1489
Score = 72.8 bits (177), Expect = 7e-13
Identities = 65/175 (37%), Positives = 74/175 (42%), Gaps = 27/175 (15%)
Query: 2 ALPPFFGQGRP-GPPPPQPPPPAPF--GCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQP 58
A P + G+G P PPPP PPP AP P P + A P PGP PG S +
Sbjct: 769 AAPQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETET 828
Query: 59 PLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPP-PGPGPP 117
P S E + GGGA VP P PP PP PG PRPPP PGP P
Sbjct: 829 PF------SPEGAFPGGGAAEEEGVPRPRAPPEPPD----PGA-----PRPPPDPGPLPL 873
Query: 118 WSPRWPEAPPPPADVLGDAALQRLRD---RQWLEAVFGTPRRAGCPVPQRTHAGP 169
PR E P V + L LR+ R L T R G P++ GP
Sbjct: 874 PGPR--EKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATARETG---PRKAGRGP 923
Score = 52.4 bits (124), Expect = 9e-07
Identities = 57/195 (29%), Positives = 66/195 (33%), Gaps = 40/195 (20%)
Query: 11 RPGPPPPQPPPP--APFGCPPPPLPSPAFP-------PPLPQRPGPFPGASAPFLQPPLA 61
RP PPP PPPP PF P PP S P P L PG P +
Sbjct: 444 RPPRPPPPPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPDDVLTVTESSRG 503
Query: 62 LQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPF-PGTDAGERP--------RPP-- 110
L E +R G G G P P PP P P P +A P R P
Sbjct: 504 LNLECLWEKARRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPVISARSPSV 563
Query: 111 -------------PPGPGPP--WSPRWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPR 155
PP P P W P P P P A + + +L W +F PR
Sbjct: 564 SSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPAPQAP-QAPSEVPQLVSETWASPLFPAPR 622
Query: 156 RAGCPVPQRTHAGPS 170
P P ++ A S
Sbjct: 623 ----PFPAQSSASGS 633
Score = 41.6 bits (96), Expect = 0.002
Identities = 66/228 (28%), Positives = 79/228 (34%), Gaps = 66/228 (28%)
Query: 4 PPFFGQGR-PGP--PPPQPPPPAP-FGCPPP-------PLPSPAFPP-------PLPQRP 45
PP G R PGP P+ PAP G P P P PS P P P
Sbjct: 1047 PPETGPWRAPGPWEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGETAPGPLGP 1106
Query: 46 GPFPGASAPFLQ---PPLALQPRA-----------------SAEASRGGGGAGA------ 79
P G P + P PRA + A GG G+G
Sbjct: 1107 APKNGTLEPGTERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGW 1166
Query: 80 ---FYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPPADVLGDA 136
P PPPP PPPP+ +P R P PP P +P E P + GD
Sbjct: 1167 VDNTRPQPPPPPLPPPPEAQP-------RRLEPAPPRARPEVAPE-GEPGAPDSRAGGDT 1218
Query: 137 ALQRLRDRQWLEAVFGTPRRAGCPVPQR-THAGPSLG---EVRARLLR 180
AL D P R G +P+ GP G +++ARL R
Sbjct: 1219 ALSGDGDPP-------KPERKGPEMPRLFLDLGPPQGNSEQIKARLSR 1259
Score = 41.2 bits (95), Expect = 0.002
Identities = 41/131 (31%), Positives = 47/131 (35%), Gaps = 33/131 (25%)
Query: 14 PPPPQPPPP---------APFGCPPPPLPS--PAFP---------------PPLPQRPGP 47
PPPP PPPP AP P P P P PP P+R GP
Sbjct: 1175 PPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPERKGP 1234
Query: 48 FPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDA---- 103
L PP + A SR + A P+ P P P P+ P+ G DA
Sbjct: 1235 EMPRLFLDLGPPQGNSEQIKARLSRL---SLALPPLTLTPFPGPGPRRPPWEGADAGAAG 1291
Query: 104 GERPRPPPPGP 114
GE PGP
Sbjct: 1292 GEAGGAGAPGP 1302
Score = 37.4 bits (85), Expect = 0.031
Identities = 40/140 (28%), Positives = 44/140 (31%), Gaps = 43/140 (30%)
Query: 26 GCPPPPLPSPAFPPP------LPQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGAGA 79
GCP PP + LP P P PP L P A A + G
Sbjct: 728 GCPHPPEDDSSLRAERGSLADLPMAP--------PASAPPEFLDPLMGAAAPQYPGRGPP 779
Query: 80 FYPVPPPPLP---------PPPPQCRPFPGTDAGERPRPPPPGPG----PPWSPRW---- 122
P PPPP P P PP PG+ P P P G P+SP
Sbjct: 780 PAPPPPPPPPRAPADPAASPDPPSAVASPGSGLSS-PGPKPGDSGYETETPFSPEGAFPG 838
Query: 123 -----------PEAPPPPAD 131
P APP P D
Sbjct: 839 GGAAEEEGVPRPRAPPEPPD 858
Score = 36.6 bits (83), Expect = 0.053
Identities = 42/157 (26%), Positives = 50/157 (31%), Gaps = 45/157 (28%)
Query: 18 QPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGA 77
+PP P+ P P P+ GP P P + L P SA S GG
Sbjct: 1046 RPPETGPWRAPGP-------WEKTPESWGPAPTIGEPAPETSLERAPAPSAVVSSRNGGE 1098
Query: 78 GAFYPVPPPPLPPPPPQCRPFPGT-----DAGERPRPP---------------------- 110
A P PL P P PGT + G PR P
Sbjct: 1099 TA-----PGPLGPAPKNGTLEPGTERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTAPG 1153
Query: 111 -PPGPGPPWSPRW-----PEAPPPPADVLGDAALQRL 141
PG G W P+ PPPP +A +RL
Sbjct: 1154 GGPGSGVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRL 1190
Score = 30.0 bits (66), Expect = 4.9
Identities = 30/91 (32%), Positives = 34/91 (37%), Gaps = 20/91 (21%)
Query: 28 PPPPLPSPAFPPPLPQRPGPF-PGASAPFLQPPLALQPRASAEASRGGGGAGAF-YPVPP 85
PP P+ PP P P P PG P S G G+F +
Sbjct: 1405 PPEGDTDPSTPPAPPTPPHPATPGDGFP----------------SNDSGFGGSFEWAEDF 1448
Query: 86 PPLPPP-PPQC-RPFPGTDAGERPRPPPPGP 114
P LPPP PP C F + A E P PP P
Sbjct: 1449 PLLPPPGPPLCFSRFSVSPALETPGPPARAP 1479
>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
tract binding protein associated) [Homo sapiens]
Length = 707
Score = 72.8 bits (177), Expect = 7e-13
Identities = 53/145 (36%), Positives = 59/145 (40%), Gaps = 21/145 (14%)
Query: 8 GQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRAS 67
GQ P PP P PPP PPP P P PPP P P P QPP Q +
Sbjct: 52 GQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQ---QPPPPPQDSSK 108
Query: 68 AEASRGGG---GAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPP------PPGPGPPW 118
++G G G G+ P P PP PG+ G P PP PPG PP
Sbjct: 109 PVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPT 168
Query: 119 SPRW------PEA---PPPPADVLG 134
P P+A PPPPA V G
Sbjct: 169 PPSSGVPTTPPQAGGPPPPPAAVPG 193
Score = 68.9 bits (167), Expect = 1e-11
Identities = 56/149 (37%), Positives = 62/149 (41%), Gaps = 26/149 (17%)
Query: 4 PPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSP---AFPPPLPQR---------PGPFPGA 51
PP Q + PPP QPPP P PPP P P PPP PQ PGP PG
Sbjct: 62 PPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGV 121
Query: 52 -SAPFLQPPLALQPRASAEASRGGGGAGAF-YPVPPPPL-------PPPPPQCRPFPGT- 101
SAP P + P A+ S G+G P PPP + PPP P P T
Sbjct: 122 GSAP---PASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTP 178
Query: 102 -DAGERPRPPPPGPGPPWSPRWPEAPPPP 129
AG P PP PGP P+ P P
Sbjct: 179 PQAGGPPPPPAAVPGPGPGPKQGPGPGGP 207
Score = 55.8 bits (133), Expect = 8e-08
Identities = 51/172 (29%), Positives = 64/172 (37%), Gaps = 31/172 (18%)
Query: 2 ALPPFFGQGRPGPPPPQPPPP-----APFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFL 56
A PP G P P P PP AP G PPP PS P PQ GP
Sbjct: 134 ATPPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGVPTTPPQAGGP--------- 184
Query: 57 QPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPG-TDAGERPRPPPPGPG 115
PP A P +G G G P P P+ PG + G P+PP G G
Sbjct: 185 PPPPAAVPGPGPGPKQGPGPGG-----PKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGG 239
Query: 116 ---------PPWSPRWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAG 158
PP+ + + PPP G + +++ D + +A RR G
Sbjct: 240 EPRGGRQHHPPYHQQHHQGPPPGGP--GGRSEEKISDSEGFKANLSLLRRPG 289
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/82 (36%), Positives = 34/82 (41%), Gaps = 7/82 (8%)
Query: 50 GASAPFLQPPLALQPRASAEASRG--GGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERP 107
G F PP P +RG G G G P PP P PPPP Q + P
Sbjct: 26 GGLHDFRSPP----PGMGLNQNRGPMGPGPGQSGPKPPIP-PPPPHQQQQQPPPQQPPPQ 80
Query: 108 RPPPPGPGPPWSPRWPEAPPPP 129
+PPP P P P + PPPP
Sbjct: 81 QPPPHQPPPHPQPHQQQQPPPP 102
Score = 34.3 bits (77), Expect = 0.26
Identities = 40/152 (26%), Positives = 70/152 (46%), Gaps = 47/152 (30%)
Query: 276 RWRVKCVQEVEEKKREQ---ELKAAADGVLSEVR----KKQADTKRMVDILRALEKLRKL 328
RW K + E+E+++REQ +K A D + SE+ + QA+ R D++R E+LR++
Sbjct: 493 RW--KSLDEMEKQQREQVEKNMKDAKDKLESEMEDAYHEHQANLLRQ-DLMRRQEELRRM 549
Query: 329 RKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRE 388
EL+ E + + M ++EE R+RE
Sbjct: 550 E----------------------------------ELHNQEMQKRKEMQLRQEEERRRRE 575
Query: 389 LEK--KQRKEKEKILLQKREIESKL-FGDPDE 417
E +QR+ +E++ Q+ E S++ + DP E
Sbjct: 576 EEMMIRQREMEEQMRRQREESYSRMGYMDPRE 607
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 72.8 bits (177), Expect = 7e-13
Identities = 58/159 (36%), Positives = 62/159 (38%), Gaps = 34/159 (21%)
Query: 3 LPPFFGQGRPGPPP-PQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLA 61
LP G P PP + PPP P PP P P P PPP P P P PP
Sbjct: 1439 LPSANSNGTPEPPLLEEKPPPTP---PPAPTPQPQ-PPPPPPPPQP------ALPSPPPL 1488
Query: 62 LQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGP-PWSP 120
+ P S+ PPPPLPPPPP P P P PPPP P P
Sbjct: 1489 VAPTPSSP--------------PPPPLPPPPPPAMPSP-------PPPPPPAAAPLAAPP 1527
Query: 121 RWPEAPPPPADVLGDAALQRLRDRQWLEAVFG-TPRRAG 158
P AP P L D L +Q AV G T AG
Sbjct: 1528 EEPAAPSPEDPELPDTRPLHLAKKQETAAVCGETDEEAG 1566
Score = 63.2 bits (152), Expect = 5e-10
Identities = 47/123 (38%), Positives = 48/123 (39%), Gaps = 38/123 (30%)
Query: 12 PGPPP-PQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEA 70
PGPPP P P G P PPL PP P P P P QPP
Sbjct: 1431 PGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQP-------QPP----------- 1472
Query: 71 SRGGGGAGAFYPVPPPP---LPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPP 127
P PPPP LP PPP P P + P PP P P PP P P PP
Sbjct: 1473 -----------PPPPPPQPALPSPPPLVAPTPSSP----PPPPLPPPPPPAMPS-PPPPP 1516
Query: 128 PPA 130
PPA
Sbjct: 1517 PPA 1519
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/134 (32%), Positives = 47/134 (35%), Gaps = 33/134 (24%)
Query: 4 PPFFGQGRPGPPPPQPPPPAPFGCPPPPLPS--------PAFPPPLPQRPGPFPGASAPF 55
PP G P P PA PPPLP PP L ++P P
Sbjct: 1408 PPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPP-------- 1459
Query: 56 LQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPG 115
PP A P+ P PPPP PPP P P A PPPP
Sbjct: 1460 -TPPPAPTPQ----------------PQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLP 1502
Query: 116 PPWSPRWPEAPPPP 129
PP P P PPPP
Sbjct: 1503 PPPPPAMPSPPPPP 1516
Score = 49.7 bits (117), Expect = 6e-06
Identities = 36/100 (36%), Positives = 42/100 (42%), Gaps = 15/100 (15%)
Query: 10 GRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAE 69
G+ GPP + P A G PP P PA+ P P PG GA P L L P E
Sbjct: 963 GKAGPPEDEGDPKAGAGPPPGP---PAYDPYGPYCPGRASGAGPE--TPGLGLDPNKPPE 1017
Query: 70 ASR-------GGGGAGAFYPVPPPPLPPPPPQCRPFPGTD 102
G +G PPPP PPPPP P P ++
Sbjct: 1018 LPSTVNAEPLGLIQSGPHQAAPPPPPPPPPP---PAPASE 1054
Score = 47.4 bits (111), Expect = 3e-05
Identities = 41/120 (34%), Positives = 50/120 (41%), Gaps = 24/120 (20%)
Query: 3 LPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLAL 62
L P G P PPPP PPPP PP PL A + G P A +P L+P +L
Sbjct: 824 LEPATRDGAPQPPPPPPPPP-----PPMPLQLEAH----LRSHGLEPAAPSPRLRPEESL 874
Query: 63 QPRASAEASRGGGGAGAFYPVPPPP----LPPPPPQCRPFPGTD-AGERPRPPPPGPGPP 117
P + + GA P+PP P + PP + G D AG P P G P
Sbjct: 875 DPPGAMQEL-----LGALEPLPPAPGDTGVGPPNSE-----GKDPAGAYRSPSPQGTKAP 924
Score = 46.2 bits (108), Expect = 7e-05
Identities = 48/136 (35%), Positives = 52/136 (38%), Gaps = 32/136 (23%)
Query: 7 FGQGRPGPPPP--QPPPPAPFG----CPPPPLPSPAFPPP-------LPQRPGPFPGASA 53
F Q P PPPP Q P P G P LP PPP L P P P AS
Sbjct: 759 FLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASK 818
Query: 54 PFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFP-GTDAGERPRP-PP 111
+ L+P A+R G P PPPP PPPPP P P +A R P
Sbjct: 819 VGVH---LLEP-----ATRDGA------PQPPPPPPPPPP---PMPLQLEAHLRSHGLEP 861
Query: 112 PGPGPPWSPRWPEAPP 127
P P P PP
Sbjct: 862 AAPSPRLRPEESLDPP 877
Score = 46.2 bits (108), Expect = 7e-05
Identities = 44/135 (32%), Positives = 50/135 (37%), Gaps = 14/135 (10%)
Query: 9 QGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQ---RPGPF---PGASAPFLQPPLAL 62
Q P PPPP PPPPAP P L SP F P+ + F PF P
Sbjct: 1036 QAAPPPPPPPPPPPAPASEPKGGLTSPIFCSTKPKKLLKTSSFHLLRRRDPPFQTPKKLY 1095
Query: 63 QPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPG-TDAGERP-RPPPPGP-GPPWS 119
EA A + P LP CR P + G+ PP PGP GP
Sbjct: 1096 AQEYEFEADEDKADVPADIRLNPRRLPDLVSSCRSRPALSPLGDIDFCPPNPGPDGPRRR 1155
Query: 120 PRWP-----EAPPPP 129
R P + PP P
Sbjct: 1156 GRKPTKAKRDGPPRP 1170
Score = 41.6 bits (96), Expect = 0.002
Identities = 42/142 (29%), Positives = 48/142 (33%), Gaps = 36/142 (25%)
Query: 7 FGQGRPGPPPPQPPPPA----------PFGCPPPPLPSPAFP-----------PPLPQRP 45
F PGPPPP+ P P PPP P PA P + R
Sbjct: 268 FSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGGSYPSMGHRA 327
Query: 46 G----------PFPGASAPFLQPPLALQPRASAEAS----RGGGGAGAFYPVPPPPLPPP 91
P PGA P P AS A+ GGGGAG P + P
Sbjct: 328 NLACSPLGGGEPSPGAGEPSKAGPSGATAGASGRATGPEAAGGGGAGGGGGGYRPIIQSP 387
Query: 92 PPQC-RPFPGTDAGERPRPPPP 112
+ + G AG RPPPP
Sbjct: 388 GYKTGKGGYGAAAGGATRPPPP 409
Score = 37.4 bits (85), Expect = 0.031
Identities = 46/181 (25%), Positives = 58/181 (32%), Gaps = 56/181 (30%)
Query: 4 PPFFGQGRPGP--PPPQPPPPAPF-GCPPPPLPSPAFPPPLP-------------QRPGP 47
PP + G P PP PP P G P P +PA P P P + G
Sbjct: 1296 PPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEGL 1355
Query: 48 FPGASAPF------LQPPLALQPRASAEASRG-----------------------GGGAG 78
G +P L+ L P S++ G
Sbjct: 1356 GLGCPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKD 1415
Query: 79 AFYPVPPPPLP----PPPPQCRPFPGTDAGERPRP------PPPGPGPPWSPRWPEAPPP 128
P PP P P PP P ++ P P PPP P P +P+ P+ PPP
Sbjct: 1416 TSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQ-PQPPPP 1474
Query: 129 P 129
P
Sbjct: 1475 P 1475
Score = 37.4 bits (85), Expect = 0.031
Identities = 25/76 (32%), Positives = 29/76 (38%), Gaps = 1/76 (1%)
Query: 58 PPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPP 117
PPLA P+ ++ A P PPP P P E PP P P P
Sbjct: 1408 PPLA-GPKDTSTPDGPPLAPAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPT 1466
Query: 118 WSPRWPEAPPPPADVL 133
P+ P PPPP L
Sbjct: 1467 PQPQPPPPPPPPQPAL 1482
Score = 37.0 bits (84), Expect = 0.040
Identities = 30/87 (34%), Positives = 33/87 (37%), Gaps = 8/87 (9%)
Query: 4 PPFFGQGRPGPPPPQPPP---PAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPL 60
PP+ RPGPP P PPP P F + A + F GA AP PP
Sbjct: 225 PPY----RPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGA-APGPPPPE 279
Query: 61 ALQPRASAEASRGGGGAGAFYPVPPPP 87
PR A A P PPPP
Sbjct: 280 RALPRQDTVIKHYQRPASAQPPPPPPP 306
Score = 36.6 bits (83), Expect = 0.053
Identities = 24/76 (31%), Positives = 33/76 (43%), Gaps = 6/76 (7%)
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPP 110
A P+ +PP+ ++ A+ GG+ A P P P PPP P+ P E+P
Sbjct: 1663 ARKPWHRPPVPVRRSGQAKNPVSAGGSSA--PPPKAPAPPPKPET---PEKTTSEKPPEQ 1717
Query: 111 PPGPGPPWSPRWPEAP 126
P P P PE P
Sbjct: 1718 TPETAMP-EPPAPEKP 1732
Score = 35.8 bits (81), Expect = 0.090
Identities = 38/124 (30%), Positives = 44/124 (35%), Gaps = 28/124 (22%)
Query: 10 GRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAE 69
G G P Q PP P G P PP P P LP + +SA A ++S +
Sbjct: 215 GPAGLGPAQTPPYRP-GPPDPPPP----PRHLPTQFNLLASSSAA-----AAAAEQSSPQ 264
Query: 70 ASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPP 129
G A P PPPP + P T RP P P PPPP
Sbjct: 265 LYNFSGAA---------PGPPPPERALPRQDTVIKHYQRPASAQPPP---------PPPP 306
Query: 130 ADVL 133
A L
Sbjct: 307 AHAL 310
Score = 33.1 bits (74), Expect = 0.58
Identities = 36/120 (30%), Positives = 40/120 (33%), Gaps = 19/120 (15%)
Query: 10 GRPGPPPPQPPPPAPFGC---PPPPLPSPAFPPPLPQRPGPFPGASA-PFLQPPLALQPR 65
G P PP PPPP C P L + PGP + P P L+
Sbjct: 477 GGPPQPPSGPPPPGLATCQSYSPDQLQGQLYGVQGEPYPGPAAHSQGLPTASPSLSYSTG 536
Query: 66 ASAEASRGGGGAGAFYPVPPPPL-----PPPPPQCRPFPGTDAGERPRPPPPGPGPPWSP 120
S S GGG G P L P RP A R PPG G P +P
Sbjct: 537 HSPALSGHGGGWG------PSSLGGGGEASPSHIIRPLQSPPATGR----PPGVGSPGAP 586
Score = 33.1 bits (74), Expect = 0.58
Identities = 42/156 (26%), Positives = 45/156 (28%), Gaps = 56/156 (35%)
Query: 74 GGGA---GAFYPVPPPP---------------------------LPPPPPQCRPF----- 98
G GA GAF PPP LPPPPPQ P
Sbjct: 750 GAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHA 809
Query: 99 ----------------PGTDAGERPRPPPPGPGPPWSPRWPEAPPPPADVLGDAALQRLR 142
P T G PPPP P PP P EA + A RLR
Sbjct: 810 PSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLR 869
Query: 143 DRQWLEAVFGTPRRAGC-----PVPQRTHAGPSLGE 173
+ L+ G P P T GP E
Sbjct: 870 PEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSE 905
Score = 31.2 bits (69), Expect = 2.2
Identities = 19/50 (38%), Positives = 21/50 (42%), Gaps = 9/50 (18%)
Query: 5 PFFGQGRPGPPPPQP-PPPAP-------FGCPPPPLPSPAFP-PPLPQRP 45
P G PPP P PPP P PP P A P PP P++P
Sbjct: 1683 PVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKP 1732
Score = 30.4 bits (67), Expect = 3.8
Identities = 43/177 (24%), Positives = 54/177 (30%), Gaps = 53/177 (29%)
Query: 11 RPGPPPPQPP--------PPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLAL 62
+P PP P P + G PP +PA PPP P+ P P P A+
Sbjct: 1665 KPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPA-PPPKPETPEKTTSEKPPEQTPETAM 1723
Query: 63 QPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPF------PGTDAGERP--------- 107
P PP P P RP GERP
Sbjct: 1724 ---------------------PEPPAPEKPSLLRPVEKEKEKEKVTRGERPLRGERATSG 1762
Query: 108 RPPPP----GPGPPWSPRWPEAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCP 160
R P G P + R P+A P A + ++WL+ G G P
Sbjct: 1763 RQTRPERSLATGQPATSRLPKARPTKV----KAEPPPKKRKKWLKEAGGNATAGGGP 1815
Score = 29.3 bits (64), Expect = 8.4
Identities = 30/110 (27%), Positives = 36/110 (32%), Gaps = 27/110 (24%)
Query: 22 PAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGAGAFY 81
PA FG P P+PS L + PF + L P L +
Sbjct: 154 PASFGSRPFPVPSS-----LSLQDPPFSPPANGLLSPHDVLHLK---------------- 192
Query: 82 PVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPG--PPWSPRWPEAPPPP 129
P P P F G P GP PP+ P P+ PPPP
Sbjct: 193 ----PSQAPTVPSSLGFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPP 238
Score = 29.3 bits (64), Expect = 8.4
Identities = 27/86 (31%), Positives = 31/86 (36%), Gaps = 24/86 (27%)
Query: 77 AGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPPADVLGDA 136
AG P+ PP PP R G +P+PP +P P PP A LG A
Sbjct: 1301 AGLTPPLSPPKSVPPSVPAR-------GLQPQPPA-------TPAVPHPPPSGAFGLGGA 1346
Query: 137 ALQRLRDRQWLEAVFGTPRRAGCPVP 162
LEA GCP P
Sbjct: 1347 ----------LEAAESEGLGLGCPSP 1362
>gi|157168329 formin 1 [Homo sapiens]
Length = 1196
Score = 72.4 bits (176), Expect = 9e-13
Identities = 53/144 (36%), Positives = 57/144 (39%), Gaps = 45/144 (31%)
Query: 2 ALPPFFG----QGRPGPPPPQ---PPPPAPFGC----PPPPLPSPAFPPPLPQRPGPFPG 50
AL P G Q + PPPP PPPP P G P PP+P + PPLP P
Sbjct: 630 ALQPMEGMASNQQKALPPPPASIPPPPPLPSGLGSLSPAPPMPPVSAGPPLPPPP----- 684
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPP 110
PP L P +SA PPPP PPPP P P G P PP
Sbjct: 685 ------PPPPPLPPPSSAG--------------PPPPPPPPPLPNSPAPPNPGGPPPAPP 724
Query: 111 PPGPGPPWSPRWPEAPPPPADVLG 134
PPG PP PPP G
Sbjct: 725 PPGLAPP---------PPPGLFFG 739
>gi|149999378 inverted formin 2 isoform 2 [Homo sapiens]
Length = 1240
Score = 71.6 bits (174), Expect = 1e-12
Identities = 53/128 (41%), Positives = 54/128 (42%), Gaps = 34/128 (26%)
Query: 14 PPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRG 73
PPPP PPP P PP P P PPPLP GA A PP P
Sbjct: 421 PPPPPPPPLLPGSSAEPPPPPP--PPPLPS-----VGAKALPTAPPPPPLP--------- 464
Query: 74 GGGAGAFYPVPPPPLPPP--------PPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEA 125
G GA P P PPLPPP PP P PG G P PPP PG W P
Sbjct: 465 --GLGAMAP-PAPPLPPPLPGSCEFLPPPPPPLPGL--GCPPPPPPLLPGMGWGP----- 514
Query: 126 PPPPADVL 133
PPPP +L
Sbjct: 515 PPPPPPLL 522
Score = 49.3 bits (116), Expect = 8e-06
Identities = 38/94 (40%), Positives = 40/94 (42%), Gaps = 23/94 (24%)
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----------PPPPQCRPFPG 100
AS P PP L P +SAE P PPPPLP PPPP P PG
Sbjct: 418 ASTPPPPPPPPLLPGSSAEPPP---------PPPPPPLPSVGAKALPTAPPPP---PLPG 465
Query: 101 TDAGERPRPPPPGPGPPWSPRWPEAPPPPADVLG 134
A P PP P P P S + PPPP LG
Sbjct: 466 LGAMAPPAPPLP-PPLPGSCEFLPPPPPPLPGLG 498
Score = 48.9 bits (115), Expect = 1e-05
Identities = 42/133 (31%), Positives = 42/133 (31%), Gaps = 41/133 (30%)
Query: 4 PPFFGQGRPGPPPPQPPPPAPFGC-----PPPPLPSPAFPPPLPQRPGPFPGASAPFLQP 58
PP G G PP P PPP P C PPPPLP PPP P
Sbjct: 461 PPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPP----------------PP 504
Query: 59 PLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERP---RPPPPGPG 115
PL G G G PPP PPP C P G G G
Sbjct: 505 PLL-----------PGMGWG------PPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLG 547
Query: 116 PPWSPRWPEAPPP 128
W P PP
Sbjct: 548 SAWVPSHRRVNPP 560
>gi|149999380 inverted formin 2 isoform 1 [Homo sapiens]
Length = 1249
Score = 71.6 bits (174), Expect = 1e-12
Identities = 53/128 (41%), Positives = 54/128 (42%), Gaps = 34/128 (26%)
Query: 14 PPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRG 73
PPPP PPP P PP P P PPPLP GA A PP P
Sbjct: 421 PPPPPPPPLLPGSSAEPPPPPP--PPPLPS-----VGAKALPTAPPPPPLP--------- 464
Query: 74 GGGAGAFYPVPPPPLPPP--------PPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEA 125
G GA P P PPLPPP PP P PG G P PPP PG W P
Sbjct: 465 --GLGAMAP-PAPPLPPPLPGSCEFLPPPPPPLPGL--GCPPPPPPLLPGMGWGP----- 514
Query: 126 PPPPADVL 133
PPPP +L
Sbjct: 515 PPPPPPLL 522
Score = 49.3 bits (116), Expect = 8e-06
Identities = 38/94 (40%), Positives = 40/94 (42%), Gaps = 23/94 (24%)
Query: 51 ASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLP----------PPPPQCRPFPG 100
AS P PP L P +SAE P PPPPLP PPPP P PG
Sbjct: 418 ASTPPPPPPPPLLPGSSAEPPP---------PPPPPPLPSVGAKALPTAPPPP---PLPG 465
Query: 101 TDAGERPRPPPPGPGPPWSPRWPEAPPPPADVLG 134
A P PP P P P S + PPPP LG
Sbjct: 466 LGAMAPPAPPLP-PPLPGSCEFLPPPPPPLPGLG 498
Score = 48.9 bits (115), Expect = 1e-05
Identities = 42/133 (31%), Positives = 42/133 (31%), Gaps = 41/133 (30%)
Query: 4 PPFFGQGRPGPPPPQPPPPAPFGC-----PPPPLPSPAFPPPLPQRPGPFPGASAPFLQP 58
PP G G PP P PPP P C PPPPLP PPP P
Sbjct: 461 PPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPP----------------PP 504
Query: 59 PLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERP---RPPPPGPG 115
PL G G G PPP PPP C P G G G
Sbjct: 505 PLL-----------PGMGWG------PPPPPPPLLPCTCSPPVAGGMEEVIVAQVDHGLG 547
Query: 116 PPWSPRWPEAPPP 128
W P PP
Sbjct: 548 SAWVPSHRRVNPP 560
>gi|150417989 cyclin K isoform 1 [Homo sapiens]
Length = 580
Score = 71.6 bits (174), Expect = 1e-12
Identities = 54/144 (37%), Positives = 56/144 (38%), Gaps = 28/144 (19%)
Query: 2 ALPPFFGQG-----RPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFL 56
ALPP +G P PP PPPP P PP P PA PPP P P P P + F
Sbjct: 460 ALPPAYGPPAHLPYHPHVYPPNPPPP-PVPPPPASFPPPAIPPPTPGYPPPPPTYNPNFP 518
Query: 57 QPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGP 116
PP L P A P PPP L PP A P PPG P
Sbjct: 519 PPPPRLPP------------THAVPPHPPPGLGLPP----------ASYPPPAVPPGGQP 556
Query: 117 PWSPRWPEAPPPPADVLGDAALQR 140
P P P PP LG AA R
Sbjct: 557 PVPPPIPPPGMPPVGGLGRAAWMR 580
Score = 58.5 bits (140), Expect = 1e-08
Identities = 53/164 (32%), Positives = 64/164 (39%), Gaps = 55/164 (33%)
Query: 12 PGPPPP--QPP---------PPAPFGC--------PPPPLPSPAF-PPPLPQRPGPFPGA 51
P PPP +PP PP P PPP P+P PPPLP RP P P +
Sbjct: 367 PAHPPPDRKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPS 426
Query: 52 S--------APFL--QPPLALQPRASAEASRGGGGAGAFYP--------------VPPPP 87
S + ++ + +LQ E G A+ P PPPP
Sbjct: 427 SYMTGMSTTSSYMSGEGYQSLQSMMKTEGPSYGALPPAYGPPAHLPYHPHVYPPNPPPPP 486
Query: 88 LPPPPPQCRPFPGTDAGERPRPPPPGPG-PPWSPRW-PEAPPPP 129
+PPPP P P PPP PG PP P + P PPPP
Sbjct: 487 VPPPPASFPP---------PAIPPPTPGYPPPPPTYNPNFPPPP 521
Score = 42.4 bits (98), Expect = 0.001
Identities = 44/152 (28%), Positives = 53/152 (34%), Gaps = 28/152 (18%)
Query: 11 RPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEA 70
+P P PQ P P P P Q+ P P QP Q + +
Sbjct: 280 QPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQPKKPSPQPSSPRQVKRAVVV 339
Query: 71 SRGGGGAGAFYPVPP--------PPLPP--PPPQCRPF----------PG-TDAGERPR- 108
S A P P PPLPP PPP +P PG DA + P+
Sbjct: 340 SPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPGPVDATDLPKV 399
Query: 109 --PPPPGPGP----PWSPRWPEAPPPPADVLG 134
PPP P P P P P PPP + + G
Sbjct: 400 QIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTG 431
Score = 37.0 bits (84), Expect = 0.040
Identities = 36/123 (29%), Positives = 42/123 (34%), Gaps = 11/123 (8%)
Query: 14 PPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRG 73
PP QP P P PS + P PQ+ P P Q A QP+ +
Sbjct: 276 PPSLQPTPQVPQ--VQQSQPSQSSEPSQPQQKDP----QQPAQQQQPAQQPKKPSPQPSS 329
Query: 74 GGGAGAFYPVPPPP----LPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPP- 128
V P PPPP+ T P PPP PP + EA PP
Sbjct: 330 PRQVKRAVVVSPKEENKAAEPPPPKIPKIETTHPPLPPAHPPPDRKPPLAAALGEAEPPG 389
Query: 129 PAD 131
P D
Sbjct: 390 PVD 392
>gi|18959210 WIRE protein [Homo sapiens]
Length = 440
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/175 (33%), Positives = 70/175 (40%), Gaps = 55/175 (31%)
Query: 3 LPPFFGQ----GRPGPPPPQP--------------------PPPAPFGCPP-----PPLP 33
LPP GQ GR GPP P P PPP P+ PP P P
Sbjct: 209 LPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSP 268
Query: 34 SPAFPPPLPQR--------PGPFPGASAPFLQPPLALQPRASAEA----SRGGGGAGAFY 81
+ P LPQR PGP G + P PP + P + +R GA
Sbjct: 269 TNESAPELPQRHNSLHRKTPGPVRGLAPP---PPTSASPSLLSNRPPPPARDPPSRGAAP 325
Query: 82 PVPPPPL-------PPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPP 129
P PPP + PPPPP R G++ R +PPPP P +P P PPPP
Sbjct: 326 PPPPPVIRNGARDAPPPPPPYR-MHGSEPPSRGKPPPP---PSRTPAGPPPPPPP 376
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/164 (28%), Positives = 53/164 (32%), Gaps = 26/164 (15%)
Query: 8 GQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRAS 67
G PP PPP PP PLP + P R P P L P
Sbjct: 169 GMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHP--------- 219
Query: 68 AEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPP 127
G P PPP+ PPP G PPPP PP P P +P
Sbjct: 220 ----------GREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSP- 268
Query: 128 PPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSL 171
++A + + L P R P P T A PSL
Sbjct: 269 -----TNESAPELPQRHNSLHRKTPGPVRGLAP-PPPTSASPSL 306
Score = 41.2 bits (95), Expect = 0.002
Identities = 21/49 (42%), Positives = 23/49 (46%), Gaps = 7/49 (14%)
Query: 4 PPFFGQGRPGPPPPQPP-------PPAPFGCPPPPLPSPAFPPPLPQRP 45
PP G PPP PP PP+ PPPP +PA PPP P P
Sbjct: 329 PPVIRNGARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPAGPPPPPPPP 377
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/102 (32%), Positives = 36/102 (35%), Gaps = 38/102 (37%)
Query: 14 PPPPQPPPPAPFGCPPPPLP---SPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEA 70
PPPP PP+ PPPP P + A P P P G+ P
Sbjct: 311 PPPPARDPPSRGAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPP---------------- 354
Query: 71 SRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPP 112
SRG PPPPP P AG P PPPP
Sbjct: 355 SRG--------------KPPPPPSRTP-----AGPPPPPPPP 377
Score = 34.7 bits (78), Expect = 0.20
Identities = 23/61 (37%), Positives = 24/61 (39%), Gaps = 23/61 (37%)
Query: 4 PPFFGQGRPGPPP-------PQPPPPAPF----------GCPPPPL------PSPAFPPP 40
PP G P PPP PPPP P+ G PPPP P P PPP
Sbjct: 318 PPSRGAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPAGPPPPPPPP 377
Query: 41 L 41
L
Sbjct: 378 L 378
Score = 30.4 bits (67), Expect = 3.8
Identities = 41/150 (27%), Positives = 52/150 (34%), Gaps = 20/150 (13%)
Query: 40 PLPQRPGPFPGASAPFLQPPL--ALQPRASAEASRG------GGGAGAFYPVPPPPLPPP 91
P+ + G A P LQ P A PR A+ G + +P P
Sbjct: 97 PVGAKDGSENLAGKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSL 156
Query: 92 PPQCRPFPGTDAGER---PRPPPPGPGPPWSPRWPEAPPPPADVLGDAALQRLRDRQWLE 148
P RP + G + PPPP PG R APP P + A R++ L
Sbjct: 157 PDLSRPNTTSSTGMKHSSSAPPPPPPG-----RRANAPPTPLPMHSSKAPAYNREKP-LP 210
Query: 149 AVFGT---PRRAGCPVPQRTHAGPSLGEVR 175
G P R G P P PS +R
Sbjct: 211 PTPGQRLHPGREGPPAPPPVKPPPSPVNIR 240
Score = 30.0 bits (66), Expect = 4.9
Identities = 13/25 (52%), Positives = 14/25 (56%), Gaps = 6/25 (24%)
Query: 1 MALPPFFGQGRPGPPPPQPPPPAPF 25
M +PP P PPPP PPPP F
Sbjct: 1 MPIPP------PPPPPPGPPPPPTF 19
Score = 29.3 bits (64), Expect = 8.4
Identities = 11/16 (68%), Positives = 11/16 (68%)
Query: 16 PPQPPPPAPFGCPPPP 31
P PPPP P G PPPP
Sbjct: 2 PIPPPPPPPPGPPPPP 17
Score = 29.3 bits (64), Expect = 8.4
Identities = 11/19 (57%), Positives = 13/19 (68%)
Query: 107 PRPPPPGPGPPWSPRWPEA 125
P PPPP PGPP P + +A
Sbjct: 4 PPPPPPPPGPPPPPTFHQA 22
Score = 29.3 bits (64), Expect = 8.4
Identities = 10/12 (83%), Positives = 10/12 (83%)
Query: 82 PVPPPPLPPPPP 93
P PPPP PPPPP
Sbjct: 6 PPPPPPGPPPPP 17
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 71.2 bits (173), Expect = 2e-12
Identities = 46/141 (32%), Positives = 60/141 (42%), Gaps = 33/141 (23%)
Query: 11 RPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEA 70
+P PP P PPPP P PPP P P PPPLP + P G++A P+ ++
Sbjct: 623 QPSPPLPPPPPPPP----PPPPPPPPPPPPLPSQSAPSAGSAA-----PMFVKYSTITRL 673
Query: 71 SRGGGGAGAFYPVPPPPL-------------------PPPPPQCRPFPGTDAGERPRPPP 111
+GA + P PP+ PPPPP P PG+ A + +P P
Sbjct: 674 QNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGS-AMAQLKPAP 732
Query: 112 PGPGPPWSPRWPEAPPPPADV 132
P P APPPP +
Sbjct: 733 CAPSLPQF----SAPPPPLKI 749
Score = 61.2 bits (147), Expect = 2e-09
Identities = 47/134 (35%), Positives = 52/134 (38%), Gaps = 34/134 (25%)
Query: 12 PGPPPPQPPPPAP----FGCPPPPLP-SPA----------FPPPLPQRPGPFPGASAPFL 56
P PP P PPP P F PPP P SP FPPP P P S P
Sbjct: 829 PTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPP----PTPPAMESQPLK 884
Query: 57 QPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCR-PFPGTDAGERPRPPPPGPG 115
P + P++ + PVP P PPPPP+ FP PPPP P
Sbjct: 885 PVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFP---------PPPPSPV 935
Query: 116 PPWSPRWPEAPPPP 129
P P PPPP
Sbjct: 936 PA-----PPPPPPP 944
Score = 55.8 bits (133), Expect = 8e-08
Identities = 41/128 (32%), Positives = 48/128 (37%), Gaps = 20/128 (15%)
Query: 16 PPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQ------PPLALQPRASAE 69
PP P PP P P P+ PP P P P P + P Q PP L P S
Sbjct: 803 PPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVV 862
Query: 70 ASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPG-PPWSPR-----WP 123
A F PPP PP + +P A P+ PP P W P P
Sbjct: 863 KQI----ASQF----PPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSP 914
Query: 124 EAPPPPAD 131
+ PPPP +
Sbjct: 915 DFPPPPPE 922
Score = 53.1 bits (126), Expect = 5e-07
Identities = 40/133 (30%), Positives = 47/133 (35%), Gaps = 32/133 (24%)
Query: 14 PPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRG 73
PPPP PPPP P P+P P LPQ P P +Q + P
Sbjct: 711 PPPPPPPPPTPGSAMAQLKPAPC-APSLPQFSAPPPPLKIHQVQHITQVAPPT------- 762
Query: 74 GGGAGAFYPVPPPPLPPP-PPQCRP---------------FPGTDAGERPRPPPPGPGPP 117
P PPPP+P P PPQ P P P P PP P
Sbjct: 763 --------PPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAK 814
Query: 118 WSPRWPEAPPPPA 130
P +P + PP+
Sbjct: 815 KQPAFPASYIPPS 827
Score = 52.0 bits (123), Expect = 1e-06
Identities = 44/130 (33%), Positives = 47/130 (36%), Gaps = 17/130 (13%)
Query: 14 PPPPQPPPPAPFGCPP--PPLPSPAFPPPLPQRP-GPFPGASAPFLQ----PPLALQPRA 66
PP P PPPP P PP PP P P P + P +AP PP QP
Sbjct: 760 PPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAF 819
Query: 67 SAEASRGGGGAGAFYPVPPPPLP--------PPPPQCRPFPGTDAGERPRPPPPGPGPPW 118
A PVPPP LP PPP P P + PPP P PP
Sbjct: 820 PASYIPPSPPTPP-VPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPP-PTPPA 877
Query: 119 SPRWPEAPPP 128
P P P
Sbjct: 878 MESQPLKPVP 887
Score = 50.1 bits (118), Expect = 5e-06
Identities = 42/141 (29%), Positives = 48/141 (34%), Gaps = 28/141 (19%)
Query: 2 ALPPFFGQGRPGPPPPQPPPPAPFGC---PPPPLPSPAFPPPLPQRPGPFPGASAPFLQP 58
A P + P P P PPPP PPPP P PA PPP P P P S
Sbjct: 900 AKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSG----- 954
Query: 59 PLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRP--------- 109
+ + S +S GG PPP P + G + E RP
Sbjct: 955 --SPGKKTSKTSSPGG--------KKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKF 1004
Query: 110 -PPPGPGPPWSPRWPEAPPPP 129
PP G P P PP
Sbjct: 1005 TPPAESGSPSKETLPPPAAPP 1025
Score = 49.7 bits (117), Expect = 6e-06
Identities = 39/132 (29%), Positives = 45/132 (34%), Gaps = 17/132 (12%)
Query: 9 QGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASA 68
+ +P P P P+P PPPP S FPPP P P P P PP P
Sbjct: 899 KAKPKWQPSSIPVPSPDFPPPPPESSLVFPPP---PPSPVPAPPPP---PPPTASPTPDK 952
Query: 69 EASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPG----------PGPPW 118
S G + P P PP P + + E P P P P
Sbjct: 953 SGSPGKKTSKTSSPGGKKP-PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESG 1011
Query: 119 SPRWPEAPPPPA 130
SP PPP A
Sbjct: 1012 SPSKETLPPPAA 1023
Score = 41.2 bits (95), Expect = 0.002
Identities = 43/168 (25%), Positives = 56/168 (33%), Gaps = 39/168 (23%)
Query: 1 MALPPFFGQGRPGPPPPQPPPPAP----FGCP-----PPPLPSPAFPPPLPQRPGPFPGA 51
+ PP P PPPP PP +P G P P PPP PQR +
Sbjct: 925 LVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSS 984
Query: 52 SAPFLQPPLALQPRASAEASR----GGGGAGAFYPVPPPPLPPPPPQCR----PFPGT-- 101
S + P +P + S+ G+ + +PPP PP P + PG
Sbjct: 985 SG--AEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQ 1042
Query: 102 -----------------DAGERPRPPPPGPGPPWSPRWPEAPPPPADV 132
E P PP PP P E P PP ++
Sbjct: 1043 QGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPE-TELPLPPIEI 1089
Score = 40.4 bits (93), Expect = 0.004
Identities = 28/82 (34%), Positives = 31/82 (37%), Gaps = 25/82 (30%)
Query: 56 LQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPG 115
L PPL+ QP+ + P PPLPPPPP PPP P
Sbjct: 605 LVPPLSPQPKIVTPYTASQ---------PSPPLPPPPP----------------PPPPPP 639
Query: 116 PPWSPRWPEAPPPPADVLGDAA 137
PP P P P A G AA
Sbjct: 640 PPPPPPPPPLPSQSAPSAGSAA 661
Score = 31.2 bits (69), Expect = 2.2
Identities = 27/103 (26%), Positives = 39/103 (37%), Gaps = 11/103 (10%)
Query: 19 PPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGAG 78
P PP+ PPPP P P P + P F G ++P + + QP+ ++ S
Sbjct: 1065 PSPPSDSDFPPPP-PETELPLPPIEIPAVFSGNTSPKV-AVVNPQPQQWSKMS------- 1115
Query: 79 AFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPR 121
PPP P + E+P P P SP+
Sbjct: 1116 --VKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPK 1156
>gi|21389357 MAPK-interacting and spindle-stabilizing protein [Homo
sapiens]
Length = 245
Score = 70.5 bits (171), Expect = 3e-12
Identities = 48/130 (36%), Positives = 51/130 (39%), Gaps = 15/130 (11%)
Query: 12 PGPPPPQPPPPAPFGCPPP--PLPSPAFPPPLPQRPGPFPGASAPFLQPPLA-------- 61
P P PP P PP+ CPPP P P+P P P P P P P P L P
Sbjct: 80 PPPGPPAPFPPSGPSCPPPGGPYPAPTVPGPGPTGPYPTPNMPFPELPRPYGAPTDPAAA 139
Query: 62 --LQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPP-- 117
L P S + G G YP P P P P P P P G P P P G PP
Sbjct: 140 GPLGPWGSMSSGPWAPGMGGQYPTPNMPYPSPGPYPAPPPPQAPGAAP-PVPWGTVPPGA 198
Query: 118 WSPRWPEAPP 127
W P P P
Sbjct: 199 WGPPAPYPAP 208
Score = 51.6 bits (122), Expect = 2e-06
Identities = 43/123 (34%), Positives = 44/123 (35%), Gaps = 33/123 (26%)
Query: 9 QGRPGPPP---PQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPR 65
QG PG P P P P G PP PS P P G +P S P PP
Sbjct: 32 QGWPGSNPWNNPSAPSSVPSGLPPSATPSTVPFGPAPT--GMYP--SVPPTGPP------ 81
Query: 66 ASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEA 125
P PP P PP P C P PG G P P PGPGP P
Sbjct: 82 ----------------PGPPAPFPPSGPSCPP-PG---GPYPAPTVPGPGPTGPYPTPNM 121
Query: 126 PPP 128
P P
Sbjct: 122 PFP 124
Score = 42.4 bits (98), Expect = 0.001
Identities = 25/69 (36%), Positives = 31/69 (44%), Gaps = 14/69 (20%)
Query: 12 PGPPPPQPP---PPAPFGCPPP---------PLPSPAFPPP--LPQRPGPFPGASAPFLQ 57
P PPPPQ P PP P+G PP P P+ ++P P P PF S P
Sbjct: 175 PAPPPPQAPGAAPPVPWGTVPPGAWGPPAPYPAPTGSYPTPGLYPTPSNPFQVPSGPSGA 234
Query: 58 PPLALQPRA 66
PP+ P +
Sbjct: 235 PPMPGGPHS 243
Score = 32.0 bits (71), Expect = 1.3
Identities = 22/55 (40%), Positives = 26/55 (47%), Gaps = 6/55 (10%)
Query: 2 ALPPF-FGQGRPGPPPPQPPPPAPFGCPPPP--LPSPAFPPPLPQRPG---PFPG 50
A PP +G PG P P PAP G P P P+P+ P +P P P PG
Sbjct: 185 AAPPVPWGTVPPGAWGPPAPYPAPTGSYPTPGLYPTPSNPFQVPSGPSGAPPMPG 239
>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
Length = 639
Score = 69.7 bits (169), Expect = 6e-12
Identities = 64/169 (37%), Positives = 69/169 (40%), Gaps = 42/169 (24%)
Query: 1 MALPPFFGQGRPGPPPPQP-PPPAPFG-------------CPPPPLPSPAFPPPLP-QRP 45
M PP G P PPPP PPP P G PPPP S A PLP Q+
Sbjct: 469 MMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQN 528
Query: 46 GPFPGASAPFLQPPLALQPRASAEASRGG---GGAGAFYPVPP---PPLPP--PPPQCRP 97
SA P Q +A+A AS G G P+PP PPLPP PPP P
Sbjct: 529 TTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPP 588
Query: 98 FPGTDAGERPRPPPPGPGPPWSPR-----------------WPEAPPPP 129
PG+ AG PPPP P PP P P APPPP
Sbjct: 589 PPGS-AGMMYAPPPP-PPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPP 635
Score = 67.0 bits (162), Expect = 4e-11
Identities = 46/119 (38%), Positives = 52/119 (43%), Gaps = 28/119 (23%)
Query: 13 GPPPP--QPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEA 70
GPPPP QPPPP P P P P PPP+ Q G P S +
Sbjct: 419 GPPPPWMQPPPP-PMNQGPHP-PGHHGPPPMDQYLGSTPVGSGVY--------------- 461
Query: 71 SRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPP 129
R G G P P +PPPPP P G +P PPP GP PPW + + PPPP
Sbjct: 462 -RLHQGKGMMPPPPMGMMPPPPP---PPSG-----QPPPPPSGPLPPWQQQQQQPPPPP 511
Score = 50.4 bits (119), Expect = 4e-06
Identities = 34/87 (39%), Positives = 36/87 (41%), Gaps = 13/87 (14%)
Query: 9 QGRPG--PPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRA 66
QG P P PP PP P G PPPP P P PG AP PP + P
Sbjct: 561 QGNPTMVPLPPGVQPPLPPGAPPPPPPPP---------PGSAGMMYAPPPPPPPPMDP-- 609
Query: 67 SAEASRGGGGAGAFYPVPPPPLPPPPP 93
S + G G P PP PPPPP
Sbjct: 610 SNFVTMMGMGVAGMPPFGMPPAPPPPP 636
Score = 37.4 bits (85), Expect = 0.031
Identities = 33/117 (28%), Positives = 39/117 (33%), Gaps = 12/117 (10%)
Query: 18 QPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPG----ASAPFLQPPLALQPRASAEASRG 73
+ P PA G P +P P P P P S +PP + + G
Sbjct: 322 EAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHG 381
Query: 74 GGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGP-GPPWSPRWPEAPPPP 129
G G P P P P P G P P GPP P W + PPPP
Sbjct: 382 MHGGG-----PGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPP--PPWMQPPPPP 431
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 69.3 bits (168), Expect = 7e-12
Identities = 58/192 (30%), Positives = 89/192 (46%), Gaps = 10/192 (5%)
Query: 224 QPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQ 283
+P TQ + E R R + R+ +ER ER+ ER R ERE+E R R K +
Sbjct: 27 KPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEK 86
Query: 284 EVEEKKREQELKAA------ADGVLSEVRKKQADTKRMVDILRALEKLRK---LRKEAAA 334
+ E KK E+E K +G E RKK+ +R E+ RK R+E
Sbjct: 87 KGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKE 146
Query: 335 RKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQR 394
R+ + +R RK + ++ E + +ER R E +ERK+E E+K+R
Sbjct: 147 RERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRE-RNRKERKKERERKER 205
Query: 395 KEKEKILLQKRE 406
+E++K +K E
Sbjct: 206 RERKKERKKKEE 217
Score = 39.7 bits (91), Expect = 0.006
Identities = 25/103 (24%), Positives = 50/103 (48%)
Query: 234 EARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQE 293
E R+ ER + R + RER ++ ER+ + ER+++ + R K + +E+K+E+E
Sbjct: 142 EERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERE 201
Query: 294 LKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARK 336
K + +K++ +R D + + ++E RK
Sbjct: 202 RKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
Score = 33.9 bits (76), Expect = 0.34
Identities = 22/60 (36%), Positives = 36/60 (60%), Gaps = 3/60 (5%)
Query: 236 RRRLERVRRRRLRLRERA--REREAEREAEAARAVEREQEID-RWRVKCVQEVEEKKREQ 292
R++ ER R+ R + RER RER+ ER+ + R ER+++ WR K + E K+R++
Sbjct: 186 RKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 69.3 bits (168), Expect = 7e-12
Identities = 58/185 (31%), Positives = 70/185 (37%), Gaps = 25/185 (13%)
Query: 1 MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGP------FPGASAP 54
+A PP + P PP PP +P PPP P P PPL P P P A+ P
Sbjct: 699 LAAPPL----QVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPP 754
Query: 55 FLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGER-PRPPPPG 113
PPL P S +P PL PPPQ P T + P PP
Sbjct: 755 PRVPPLLAAPPLQVPPSPPAS-------LPMSPLAKPPPQAPPALATPPLQALPSPPASF 807
Query: 114 PG-PPWSPRWP------EAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTH 166
PG P+SP PPP A + A L ++ PRR P P +
Sbjct: 808 PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSV 867
Query: 167 AGPSL 171
+GP L
Sbjct: 868 SGPRL 872
Score = 61.6 bits (148), Expect = 2e-09
Identities = 44/139 (31%), Positives = 50/139 (35%), Gaps = 12/139 (8%)
Query: 4 PPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQ 63
PP P PP PP+ P PSP PP+ P P A P PPL +
Sbjct: 679 PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVP 738
Query: 64 PRASAEASRGGGGAGAFYPVPPPPLPP----PPPQCRPFPGTDAGERP--RPPPPGPGPP 117
P A PPP +PP PP Q P P P +PPP P
Sbjct: 739 PSPPASPPMSPSA------TPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPAL 792
Query: 118 WSPRWPEAPPPPADVLGDA 136
+P P PPA G A
Sbjct: 793 ATPPLQALPSPPASFPGQA 811
Score = 61.2 bits (147), Expect = 2e-09
Identities = 47/123 (38%), Positives = 52/123 (42%), Gaps = 12/123 (9%)
Query: 12 PGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEAS 71
P PPP PP APF P P SP+ PP Q P P +AP LQ P + P AS S
Sbjct: 664 PFSPPPSPPVQAPFSPPASPPVSPSATPP-SQAP---PSLAAPPLQVPPS--PPASPPMS 717
Query: 72 RGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPW--SPRWPEAPPPP 129
P PPPL PP Q P P P PP PP +P P PP
Sbjct: 718 PSATPP----PQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPP 773
Query: 130 ADV 132
A +
Sbjct: 774 ASL 776
Score = 59.3 bits (142), Expect = 8e-09
Identities = 53/145 (36%), Positives = 59/145 (40%), Gaps = 26/145 (17%)
Query: 1 MALPPFFGQGRPGPPPPQ---PPPPAPFGCPPPPL---PSPAFPPPLPQRPGPFPGA--- 51
+A PP QG P PP PPP AP PPL PSP PPL P P A
Sbjct: 598 LASPPL--QGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNA 655
Query: 52 -SAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPP--PPPQCRPFPGTDAGERPR 108
+ LQ P + P +A F P PP+ P PP P P A
Sbjct: 656 LAVHLLQAPFSPPPSPPVQAP--------FSPPASPPVSPSATPPSQAP-PSLAAPPLQV 706
Query: 109 PPPPGPGPPWSPRW---PEAPPPPA 130
PP P PP SP P+APPP A
Sbjct: 707 PPSPPASPPMSPSATPPPQAPPPLA 731
Score = 51.2 bits (121), Expect = 2e-06
Identities = 42/124 (33%), Positives = 45/124 (36%), Gaps = 9/124 (7%)
Query: 15 PPPQPPP----PAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLA--LQPRASA 68
PPPQ PP P G P PPL A PPP P AP PP + L P A+
Sbjct: 590 PPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAP-PSPPASPPLSPLATP 648
Query: 69 EASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPP--WSPRWPEAP 126
A P P P PP Q P P PP PP +P P
Sbjct: 649 SPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 708
Query: 127 PPPA 130
PPA
Sbjct: 709 SPPA 712
Score = 50.8 bits (120), Expect = 3e-06
Identities = 46/146 (31%), Positives = 52/146 (35%), Gaps = 20/146 (13%)
Query: 1 MALPPFFGQGRPGPPPPQPPPPAPFGC-----------PPPPLPSPAFPPPLPQRP---- 45
+A PP P P PP P C PPP PS PP PQ P
Sbjct: 541 LAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPP-PQAPPALA 599
Query: 46 -GPFPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPP--PLPPPPPQCRPFPGTD 102
P G +P L P P+A + A P PP PL P PQ
Sbjct: 600 SPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH 659
Query: 103 AGERPRPPPPGPGPPWSPRWPEAPPP 128
+ P PPP P P +P P A PP
Sbjct: 660 LLQAPFSPPPSP-PVQAPFSPPASPP 684
Score = 50.4 bits (119), Expect = 4e-06
Identities = 46/134 (34%), Positives = 52/134 (38%), Gaps = 26/134 (19%)
Query: 1 MALPPFFGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPL 60
+ +PP Q PP Q PP + P LPS A PPPL ASAP P L
Sbjct: 507 LIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLA-PPPLQT-------ASAPLTTPHL 558
Query: 61 ALQPRASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPP-----PPGPG 115
P A PP PL PPP+ P + A P+ P PP G
Sbjct: 559 ETPPCP----------APCPLQAPPSPLTTPPPET---PSSIATPPPQAPPALASPPLQG 605
Query: 116 PPWSPRWPEAPPPP 129
P P P A PPP
Sbjct: 606 LPSPPLSPLATPPP 619
Score = 46.2 bits (108), Expect = 7e-05
Identities = 33/110 (30%), Positives = 39/110 (35%), Gaps = 11/110 (10%)
Query: 24 PFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPV 83
P P PS P P P L+PP PR A + G P+
Sbjct: 248 PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG--------PL 299
Query: 84 PPPPLPPPPP---QCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPPPA 130
PL P P + RP P D P P P PP + P APP P+
Sbjct: 300 SSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPS 349
Score = 43.5 bits (101), Expect = 4e-04
Identities = 65/229 (28%), Positives = 81/229 (35%), Gaps = 42/229 (18%)
Query: 15 PPPQPPP--PAP-FGCPPPPLPSPAFPPP-LPQRPGPFPGASAPFLQPPLALQPRASAEA 70
PPPQ PP AP PP P SP P P PGP S P L LA P
Sbjct: 827 PPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR 886
Query: 71 SRGGGGAGAFYPVPPPPLPPPPPQCRPF-PGTDAGERPRPPPP-------------GPGP 116
S +G P + R + G + G PPP GP P
Sbjct: 887 SPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAP 946
Query: 117 PWSPRWPEAPP---PPADVLGDA-ALQRLRDRQWLEAVFGTP-----------------R 155
P + R P PPA G A L + + + E+ P
Sbjct: 947 PLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAA 1006
Query: 156 RAGCPVPQRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAA 204
AG R+ LGE+ L+A +V+ L LS+ L A A+GAA
Sbjct: 1007 GAGAGASSRSPKQARLGELPLGALQA-SVVQHL--LSRTLLLAAAEGAA 1052
Score = 41.2 bits (95), Expect = 0.002
Identities = 36/125 (28%), Positives = 43/125 (34%), Gaps = 8/125 (6%)
Query: 9 QGRPGPP--PPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQP-PLALQPR 65
+G P P P QP P PP + PP P P +S+P P P + R
Sbjct: 260 RGTPRAPAHPSQPKPKGLQALRPPQVT----PPRKDAAPALGPLSSSPLATPSPSGTKAR 315
Query: 66 ASAEASRGGGGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEA 125
A P P PPL P P P P + P PP P +P
Sbjct: 316 PVPPPDNAATPLPATLP-PSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTT 374
Query: 126 PPPPA 130
PP A
Sbjct: 375 PPMQA 379
Score = 40.0 bits (92), Expect = 0.005
Identities = 33/102 (32%), Positives = 38/102 (37%), Gaps = 19/102 (18%)
Query: 9 QGRPGPPPPQPPPPAPFGCPP-PPLPSPA-FPPPLPQRPG-----PFPGASAPFLQPPLA 61
+ RP PPP P P PP PPL +P PP P P P P A+ P PP
Sbjct: 313 KARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSM 372
Query: 62 LQPRASAEASRGGGGAGAFYPVPPPPLP----PPPPQCRPFP 99
P A S +PP +P P Q P P
Sbjct: 373 TTPPMQAPPS--------LQTIPPIQVPHSLTSPSLQAPPSP 406
Score = 39.7 bits (91), Expect = 0.006
Identities = 46/135 (34%), Positives = 50/135 (37%), Gaps = 24/135 (17%)
Query: 15 PPPQPPPPAPFGCP-PPPLP---SPAFPP---PLPQRP--------GPFPGAS-APFLQP 58
PP PP AP P PPL SPA P PL P P A + + P
Sbjct: 451 PPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMP 510
Query: 59 PLALQPRASAEASRGGGGAGAFYPVPP----PPLPPPPPQCRPFPGTDAGERPRPPPPGP 114
PL Q S+ A A PP P L PPP Q P T PP P P
Sbjct: 511 PLETQ---SSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLT-TPHLETPPCPAP 566
Query: 115 GPPWSPRWPEAPPPP 129
P +P P PPP
Sbjct: 567 CPLQAPPSPLTTPPP 581
Score = 35.4 bits (80), Expect = 0.12
Identities = 37/121 (30%), Positives = 43/121 (35%), Gaps = 19/121 (15%)
Query: 9 QGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASA 68
+ + G P AP P P SP PPP+ GA+ + PL
Sbjct: 7 KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPL-------- 58
Query: 69 EASRGGGGAGAFYPVPPPPLPPP--------PPQCRPFPGTDAGERPRPPP-PGPGPPWS 119
A R GG GA P P P P RP P + GER P PGP S
Sbjct: 59 -AERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRP-PASGRGERAPPAKNTSPGPVSS 116
Query: 120 P 120
P
Sbjct: 117 P 117
Score = 33.1 bits (74), Expect = 0.58
Identities = 20/55 (36%), Positives = 21/55 (38%), Gaps = 6/55 (10%)
Query: 4 PPFFGQGRPGPPPPQPPPPAPFGCP------PPPLPSPAFPPPLPQRPGPFPGAS 52
PP +G PG P P PP P P A P P PGP PG S
Sbjct: 946 PPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTS 1000
Score = 31.6 bits (70), Expect = 1.7
Identities = 44/175 (25%), Positives = 49/175 (28%), Gaps = 16/175 (9%)
Query: 7 FGQGRPGPPPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRA 66
+ G G PPP A P S PPL R P AP PP
Sbjct: 914 YDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAP----GAPLPWPP------- 962
Query: 67 SAEASRGGGGAGAFYPVPPPPLPPPPPQC---RPFPGTDAGERPRPPPPGPGPPWSPRWP 123
A G Y P P P P PGT G+ G SP+
Sbjct: 963 -ATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSR-SPKQA 1020
Query: 124 EAPPPPADVLGDAALQRLRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLGEVRARL 178
P L + +Q L R L A P G G RA L
Sbjct: 1021 RLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAAL 1075
Score = 30.4 bits (67), Expect = 3.8
Identities = 29/114 (25%), Positives = 41/114 (35%), Gaps = 5/114 (4%)
Query: 15 PPPQPPPPAPFGCPPPPLPSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRGG 74
PP PP AP PP+ +P +P P ++P LQ P + +S +A+
Sbjct: 360 PPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPH-SLTSPSLQAPPSPLALSSLQATTSL 418
Query: 75 GGAGAFYPVPPPPLPPPPPQCRPFPGTDAGERPRPPPPGPGPPWSPRWPEAPPP 128
G + P Q + RP PP P +P A PP
Sbjct: 419 GSPTLQATHSFLTMSPRQTQA----SLTSPSRPASTPPDSPPLQAPLSLPASPP 468
Score = 29.6 bits (65), Expect = 6.4
Identities = 36/152 (23%), Positives = 47/152 (30%), Gaps = 33/152 (21%)
Query: 33 PSPAFPPPLPQRPGPFPGASAPFLQPPLALQPRASAEASRGGGGAGAFYPVPPPPLPPPP 92
P+P P P R G +P + +PR E R + + + P P
Sbjct: 167 PTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTE---PSPA 223
Query: 93 PQCRPFPG------------TDAGERPRPPPPGPGPPWSPRWPEAPPPPADVLGDAALQR 140
+ RP G + A P GP +PR P P P LQ
Sbjct: 224 ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPK----PKGLQA 279
Query: 141 LRDRQWLEAVFGTPRRAGCPVPQRTHAGPSLG 172
LR Q P R A P+LG
Sbjct: 280 LRPPQ--------------VTPPRKDAAPALG 297
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 69.3 bits (168), Expect = 7e-12
Identities = 68/268 (25%), Positives = 122/268 (45%), Gaps = 13/268 (4%)
Query: 155 RRAGCPVPQRTHAGPSLGEVRARLLRALRLVR-RLRGLSQALREAEADGAAWVLLYSQTA 213
R+A + R A + R L+AL +R + + LR+AE + A V + +TA
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 214 PLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVER-EQ 272
AE + + + A + R L+ +LRE A ER A+++AEA RA E E+
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAERAREEAER 1629
Query: 273 EIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEA 332
E++RW++K + + + + +E+ +E K++ + +R E+ ++E
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689
Query: 333 AARKGVCPPASADETFTHHLQRLRKLIKKRSELYEA-------EERALRVMLEGEQEEER 385
A ++ A+ T L ++LI+ R+E + EE R+ E ++
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 386 KRELE---KKQRKEKEKILLQKREIESK 410
++ELE K R E E +L K E +
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEE 1777
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/224 (26%), Positives = 97/224 (43%), Gaps = 19/224 (8%)
Query: 193 QALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRR-LERVRRRRLRLRE 251
+A EAE + W L ++ LR + E Q + A E ++ ER RRR + E
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1681
Query: 252 RA-RERE-AEREAEAARAVER---------EQEIDRWRVKCVQEVEEKKREQELKAAADG 300
+A R+RE AE+E E R + EQE+ R R E ++ EQ+ + +
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEE 1735
Query: 301 VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK 360
+ R+ A T++ ++ L K+R + A K S T QRL
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR-STSEKSKQRLEAEAG 1794
Query: 361 KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQK 404
+ EL E R + E +++ + E +QR E E++L +K
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838
Score = 49.7 bits (117), Expect = 6e-06
Identities = 61/268 (22%), Positives = 111/268 (41%), Gaps = 52/268 (19%)
Query: 196 REAEADGAAWVLLYSQTAPLRAELA---ERLQPLTQAAYVGEARRRLERVRRRRLRLRER 252
R+ E + A + + A +AEL R++ + + + LE R+R+L E
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 253 AREREAEREAEAARAVERE---------QEIDRWRVK--------------------CVQ 283
R REAE + + A E E +E++R + K Q
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 284 EVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRAL----EKLRKLRKEA-AARKGV 338
E +K+ + E KA A V + ++ Q ++ +L L E R+ +EA AR
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 339 CPPASADETFTHHLQRLRKLIKKRSEL-YEAEERALRVMLEGEQEEERKRELE------- 390
A+ +RL++ +++++ +A+ A ++ E EQE R+ + E
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 391 -------KKQRKEKEKILLQKREIESKL 411
+K +K E+ L QK ++E +L
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Score = 47.0 bits (110), Expect = 4e-05
Identities = 49/216 (22%), Positives = 98/216 (45%), Gaps = 10/216 (4%)
Query: 231 YVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKR 290
++ E RR+E RL ++RA ERE E EAA +R+ + K E E K+
Sbjct: 1336 FISETLRRMEE--EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 291 EQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAAR-KGVCPPASADETFT 349
+Q ++ VR+++A E+L++LR+ + A + A A E
Sbjct: 1394 QQRMQEEV------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 350 HHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIES 409
++ ++++ + E E + L+ + + E +K+Q +E+ + L ++ + ES
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 410 KLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIR 445
+ E LA ++ + + + +L AL ++R
Sbjct: 1508 QRKRQA-EVELASRVKAEAEAAREKQRALQALEELR 1542
Score = 43.1 bits (100), Expect = 6e-04
Identities = 60/250 (24%), Positives = 107/250 (42%), Gaps = 19/250 (7%)
Query: 173 EVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYV 232
E R RL + + R L++A +A+A + L+ + E + +AA
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAER------EAKELQQRMQEEVVRREEAAVD 1410
Query: 233 GEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKRE- 291
+ ++R + ++LR A + R+AEAA E + V+ E E++R
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 292 -----QELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADE 346
Q L+A A+ ++ R+ Q + +R+ ++ E RK + E V A A
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR 1529
Query: 347 TFTHHLQRLRKLIKKRSE----LYEAE-ERALRVMLEGE-QEEERKRELEKKQRKEKEKI 400
LQ L +L + E L +AE ERA +V + E + + EL+ K+ EK
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 401 LLQKREIESK 410
+R ++ +
Sbjct: 1590 AQLERSLQEE 1599
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 177 RLLRALRLVRRLRGLSQALR-EAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEA 235
R L L +++ + +A R +AEA+ L Q L E A RLQ + +
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAE------LLQQQKELAQEQARRLQEDKE-----QM 2353
Query: 236 RRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELK 295
++L + R E R+R+ E AEA R R E+ R + + ++ Q +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA------QRFR 2407
Query: 296 AAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRL 355
A+ + ++ + + T+ V +++ LE R+ A R + + E LQ+
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQE 2465
Query: 356 RKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESK 410
KL++ +SE + ++ EQ + + L++ EK+ +L ++R IE +
Sbjct: 2466 AKLLQLKSEEMQT--------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/256 (25%), Positives = 102/256 (39%), Gaps = 38/256 (14%)
Query: 181 ALRLVRRLRGL---SQALRE-AEADGAAWVLLYSQTAPLRAELAERL------------- 223
AL V RL+ ++ LRE AE + A + L + A R + E+
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 224 QPLTQAAYV-----GEA---RRRLERVRRRRLRL-RERAREREAEREAEAARAVEREQEI 274
Q L Q V GEA RR E R++ RE A+ R EAE + EQ
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126
Query: 275 DRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAA 334
R + + E K+ EQE A + +R+KQA M EK +K ++
Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM-------EKHKKFAEQTLR 2179
Query: 335 RKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQR 394
+K A ++ T +L + +++ L E +R E ++ + E R
Sbjct: 2180 QK-----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 395 KEKEKILLQKREIESK 410
+ E++ K IE++
Sbjct: 2235 VQMEELSKLKARIEAE 2250
Score = 38.9 bits (89), Expect = 0.011
Identities = 73/298 (24%), Positives = 119/298 (39%), Gaps = 58/298 (19%)
Query: 164 RTHAGPSLGEVRARLLRA--LRLVRRLRGLSQALREAEAD----GAAWVLLYSQTAPLRA 217
R A GE + +LL RL R +Q +E EA+ A +L + A
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 218 ELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERARERE------AEREAEAARAV- 268
E + Q A G R E R R E R+R+ A + AEA R +
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 269 ---------------------EREQEIDRWRVKCVQEVEEKKREQEL----KAAADGVLS 303
E+E E +R R E +++R +E KA + L+
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 304 EVRK-KQADTKRMVDILR-ALEKLRKLRKEAAARKGVCPPASADET-FTHHLQRLRK--- 357
++RK ++ +R ++ L + R++ +E A K A+A + L R+R
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956
Query: 358 ---LIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRK----EKEKILLQKREIE 408
K+++EL A +R L +EE R+RE E++ +K E+E +K +E
Sbjct: 1957 DTLRSKEQAELEAARQRQL-----AAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Score = 31.2 bits (69), Expect = 2.2
Identities = 32/145 (22%), Positives = 67/145 (46%), Gaps = 14/145 (9%)
Query: 163 QRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAER 222
Q H L E A L R +++ L Q E LL A ++ L+E+
Sbjct: 2440 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499
Query: 223 LQPLTQAAYVGEARRRLERV------RRRRLRLRERAREREAEREA--------EAARAV 268
L + ++ + + +LE++ + ++LR ++ ++++ E+E EA R
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 269 EREQEIDRWRVKCVQEVEEKKREQE 293
+E R + + +Q++E+++R+QE
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQE 2584
Score = 30.8 bits (68), Expect = 2.9
Identities = 56/244 (22%), Positives = 101/244 (41%), Gaps = 25/244 (10%)
Query: 148 EAVFGTPRRAGCPVPQRTHAGPSLGEV-RARLLRALRLVRRLRGLSQALREAEADGAAWV 206
E V P + R+ +LG++ + R L A+ L +L+ +S +R + GA V
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQ--GAEEV 1104
Query: 207 LLYSQTAPLRAELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERAREREAEREAEA 264
L + A+ P +A A + + R + E + LR+ R + E
Sbjct: 1105 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1164
Query: 265 ARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRA-LE 323
R ER+ E++RWR + Q +E + L ++ ++ + D L A L+
Sbjct: 1165 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1224
Query: 324 KLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEE 383
R+ +++ A P A + Q +R+ +++ L E ER GE+ E
Sbjct: 1225 DARRRQEQIQA----MPLADS--------QAVREQLRQEQALLEEIER------HGEKVE 1266
Query: 384 ERKR 387
E +R
Sbjct: 1267 ECQR 1270
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 69.3 bits (168), Expect = 7e-12
Identities = 68/268 (25%), Positives = 122/268 (45%), Gaps = 13/268 (4%)
Query: 155 RRAGCPVPQRTHAGPSLGEVRARLLRALRLVR-RLRGLSQALREAEADGAAWVLLYSQTA 213
R+A + R A + R L+AL +R + + LR+AE + A V + +TA
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1574
Query: 214 PLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVER-EQ 272
AE + + + A + R L+ +LRE A ER A+++AEA RA E E+
Sbjct: 1575 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAERAREEAER 1633
Query: 273 EIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEA 332
E++RW++K + + + + +E+ +E K++ + +R E+ ++E
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1693
Query: 333 AARKGVCPPASADETFTHHLQRLRKLIKKRSELYEA-------EERALRVMLEGEQEEER 385
A ++ A+ T L ++LI+ R+E + EE R+ E ++
Sbjct: 1694 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1753
Query: 386 KRELE---KKQRKEKEKILLQKREIESK 410
++ELE K R E E +L K E +
Sbjct: 1754 RQELEAELAKVRAEMEVLLASKARAEEE 1781
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/224 (26%), Positives = 97/224 (43%), Gaps = 19/224 (8%)
Query: 193 QALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRR-LERVRRRRLRLRE 251
+A EAE + W L ++ LR + E Q + A E ++ ER RRR + E
Sbjct: 1626 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1685
Query: 252 RA-RERE-AEREAEAARAVER---------EQEIDRWRVKCVQEVEEKKREQELKAAADG 300
+A R+RE AE+E E R + EQE+ R R E ++ EQ+ + +
Sbjct: 1686 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEE 1739
Query: 301 VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK 360
+ R+ A T++ ++ L K+R + A K S T QRL
Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR-STSEKSKQRLEAEAG 1798
Query: 361 KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQK 404
+ EL E R + E +++ + E +QR E E++L +K
Sbjct: 1799 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1842
Score = 49.7 bits (117), Expect = 6e-06
Identities = 61/268 (22%), Positives = 111/268 (41%), Gaps = 52/268 (19%)
Query: 196 REAEADGAAWVLLYSQTAPLRAELA---ERLQPLTQAAYVGEARRRLERVRRRRLRLRER 252
R+ E + A + + A +AEL R++ + + + LE R+R+L E
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1984
Query: 253 AREREAEREAEAARAVERE---------QEIDRWRVK--------------------CVQ 283
R REAE + + A E E +E++R + K Q
Sbjct: 1985 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044
Query: 284 EVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRAL----EKLRKLRKEA-AARKGV 338
E +K+ + E KA A V + ++ Q ++ +L L E R+ +EA AR
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2104
Query: 339 CPPASADETFTHHLQRLRKLIKKRSEL-YEAEERALRVMLEGEQEEERKRELE------- 390
A+ +RL++ +++++ +A+ A ++ E EQE R+ + E
Sbjct: 2105 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2164
Query: 391 -------KKQRKEKEKILLQKREIESKL 411
+K +K E+ L QK ++E +L
Sbjct: 2165 QAADAEMEKHKKFAEQTLRQKAQVEQEL 2192
Score = 47.0 bits (110), Expect = 4e-05
Identities = 49/216 (22%), Positives = 98/216 (45%), Gaps = 10/216 (4%)
Query: 231 YVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKR 290
++ E RR+E RL ++RA ERE E EAA +R+ + K E E K+
Sbjct: 1340 FISETLRRMEE--EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1397
Query: 291 EQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAAR-KGVCPPASADETFT 349
+Q ++ VR+++A E+L++LR+ + A + A A E
Sbjct: 1398 QQRMQEEV------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451
Query: 350 HHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIES 409
++ ++++ + E E + L+ + + E +K+Q +E+ + L ++ + ES
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511
Query: 410 KLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIR 445
+ E LA ++ + + + +L AL ++R
Sbjct: 1512 QRKRQA-EVELASRVKAEAEAAREKQRALQALEELR 1546
Score = 43.1 bits (100), Expect = 6e-04
Identities = 60/250 (24%), Positives = 107/250 (42%), Gaps = 19/250 (7%)
Query: 173 EVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYV 232
E R RL + + R L++A +A+A + L+ + E + +AA
Sbjct: 1361 EERERLAEVEAALEKQRQLAEAHAQAKAQAER------EAKELQQRMQEEVVRREEAAVD 1414
Query: 233 GEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKRE- 291
+ ++R + ++LR A + R+AEAA E + V+ E E++R
Sbjct: 1415 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474
Query: 292 -----QELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADE 346
Q L+A A+ ++ R+ Q + +R+ ++ E RK + E V A A
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR 1533
Query: 347 TFTHHLQRLRKLIKKRSE----LYEAE-ERALRVMLEGE-QEEERKRELEKKQRKEKEKI 400
LQ L +L + E L +AE ERA +V + E + + EL+ K+ EK
Sbjct: 1534 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1593
Query: 401 LLQKREIESK 410
+R ++ +
Sbjct: 1594 AQLERSLQEE 1603
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 177 RLLRALRLVRRLRGLSQALR-EAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEA 235
R L L +++ + +A R +AEA+ L Q L E A RLQ + +
Sbjct: 2309 RALAEKMLKEKMQAVQEATRLKAEAE------LLQQQKELAQEQARRLQEDKE-----QM 2357
Query: 236 RRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELK 295
++L + R E R+R+ E AEA R R E+ R + + ++ Q +
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA------QRFR 2411
Query: 296 AAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRL 355
A+ + ++ + + T+ V +++ LE R+ A R + + E LQ+
Sbjct: 2412 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQE 2469
Query: 356 RKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESK 410
KL++ +SE + ++ EQ + + L++ EK+ +L ++R IE +
Sbjct: 2470 AKLLQLKSEEMQT--------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2516
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/256 (25%), Positives = 102/256 (39%), Gaps = 38/256 (14%)
Query: 181 ALRLVRRLRGL---SQALRE-AEADGAAWVLLYSQTAPLRAELAERL------------- 223
AL V RL+ ++ LRE AE + A + L + A R + E+
Sbjct: 2011 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070
Query: 224 QPLTQAAYV-----GEA---RRRLERVRRRRLRL-RERAREREAEREAEAARAVEREQEI 274
Q L Q V GEA RR E R++ RE A+ R EAE + EQ
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2130
Query: 275 DRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAA 334
R + + E K+ EQE A + +R+KQA M EK +K ++
Sbjct: 2131 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM-------EKHKKFAEQTLR 2183
Query: 335 RKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQR 394
+K A ++ T +L + +++ L E +R E ++ + E R
Sbjct: 2184 QK-----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238
Query: 395 KEKEKILLQKREIESK 410
+ E++ K IE++
Sbjct: 2239 VQMEELSKLKARIEAE 2254
Score = 38.9 bits (89), Expect = 0.011
Identities = 73/298 (24%), Positives = 119/298 (39%), Gaps = 58/298 (19%)
Query: 164 RTHAGPSLGEVRARLLRA--LRLVRRLRGLSQALREAEAD----GAAWVLLYSQTAPLRA 217
R A GE + +LL RL R +Q +E EA+ A +L + A
Sbjct: 1721 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1780
Query: 218 ELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERARERE------AEREAEAARAV- 268
E + Q A G R E R R E R+R+ A + AEA R +
Sbjct: 1781 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1840
Query: 269 ---------------------EREQEIDRWRVKCVQEVEEKKREQEL----KAAADGVLS 303
E+E E +R R E +++R +E KA + L+
Sbjct: 1841 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1900
Query: 304 EVRK-KQADTKRMVDILR-ALEKLRKLRKEAAARKGVCPPASADET-FTHHLQRLRK--- 357
++RK ++ +R ++ L + R++ +E A K A+A + L R+R
Sbjct: 1901 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1960
Query: 358 ---LIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRK----EKEKILLQKREIE 408
K+++EL A +R L +EE R+RE E++ +K E+E +K +E
Sbjct: 1961 DTLRSKEQAELEAARQRQL-----AAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013
Score = 31.2 bits (69), Expect = 2.2
Identities = 32/145 (22%), Positives = 67/145 (46%), Gaps = 14/145 (9%)
Query: 163 QRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAER 222
Q H L E A L R +++ L Q E LL A ++ L+E+
Sbjct: 2444 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2503
Query: 223 LQPLTQAAYVGEARRRLERV------RRRRLRLRERAREREAEREA--------EAARAV 268
L + ++ + + +LE++ + ++LR ++ ++++ E+E EA R
Sbjct: 2504 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2563
Query: 269 EREQEIDRWRVKCVQEVEEKKREQE 293
+E R + + +Q++E+++R+QE
Sbjct: 2564 HEAEEGVRRKQEELQQLEQQRRQQE 2588
Score = 30.8 bits (68), Expect = 2.9
Identities = 56/244 (22%), Positives = 101/244 (41%), Gaps = 25/244 (10%)
Query: 148 EAVFGTPRRAGCPVPQRTHAGPSLGEV-RARLLRALRLVRRLRGLSQALREAEADGAAWV 206
E V P + R+ +LG++ + R L A+ L +L+ +S +R + GA V
Sbjct: 1052 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQ--GAEEV 1108
Query: 207 LLYSQTAPLRAELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERAREREAEREAEA 264
L + A+ P +A A + + R + E + LR+ R + E
Sbjct: 1109 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1168
Query: 265 ARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRA-LE 323
R ER+ E++RWR + Q +E + L ++ ++ + D L A L+
Sbjct: 1169 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1228
Query: 324 KLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEE 383
R+ +++ A P A + Q +R+ +++ L E ER GE+ E
Sbjct: 1229 DARRRQEQIQA----MPLADS--------QAVREQLRQEQALLEEIER------HGEKVE 1270
Query: 384 ERKR 387
E +R
Sbjct: 1271 ECQR 1274
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 69.3 bits (168), Expect = 7e-12
Identities = 68/268 (25%), Positives = 122/268 (45%), Gaps = 13/268 (4%)
Query: 155 RRAGCPVPQRTHAGPSLGEVRARLLRALRLVR-RLRGLSQALREAEADGAAWVLLYSQTA 213
R+A + R A + R L+AL +R + + LR+AE + A V + +TA
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1570
Query: 214 PLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVER-EQ 272
AE + + + A + R L+ +LRE A ER A+++AEA RA E E+
Sbjct: 1571 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAERAREEAER 1629
Query: 273 EIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEA 332
E++RW++K + + + + +E+ +E K++ + +R E+ ++E
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689
Query: 333 AARKGVCPPASADETFTHHLQRLRKLIKKRSELYEA-------EERALRVMLEGEQEEER 385
A ++ A+ T L ++LI+ R+E + EE R+ E ++
Sbjct: 1690 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 386 KRELE---KKQRKEKEKILLQKREIESK 410
++ELE K R E E +L K E +
Sbjct: 1750 RQELEAELAKVRAEMEVLLASKARAEEE 1777
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/224 (26%), Positives = 97/224 (43%), Gaps = 19/224 (8%)
Query: 193 QALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRR-LERVRRRRLRLRE 251
+A EAE + W L ++ LR + E Q + A E ++ ER RRR + E
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1681
Query: 252 RA-RERE-AEREAEAARAVER---------EQEIDRWRVKCVQEVEEKKREQELKAAADG 300
+A R+RE AE+E E R + EQE+ R R E ++ EQ+ + +
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEE 1735
Query: 301 VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK 360
+ R+ A T++ ++ L K+R + A K S T QRL
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR-STSEKSKQRLEAEAG 1794
Query: 361 KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQK 404
+ EL E R + E +++ + E +QR E E++L +K
Sbjct: 1795 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838
Score = 49.7 bits (117), Expect = 6e-06
Identities = 61/268 (22%), Positives = 111/268 (41%), Gaps = 52/268 (19%)
Query: 196 REAEADGAAWVLLYSQTAPLRAELA---ERLQPLTQAAYVGEARRRLERVRRRRLRLRER 252
R+ E + A + + A +AEL R++ + + + LE R+R+L E
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 253 AREREAEREAEAARAVERE---------QEIDRWRVK--------------------CVQ 283
R REAE + + A E E +E++R + K Q
Sbjct: 1981 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 284 EVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRAL----EKLRKLRKEA-AARKGV 338
E +K+ + E KA A V + ++ Q ++ +L L E R+ +EA AR
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2100
Query: 339 CPPASADETFTHHLQRLRKLIKKRSEL-YEAEERALRVMLEGEQEEERKRELE------- 390
A+ +RL++ +++++ +A+ A ++ E EQE R+ + E
Sbjct: 2101 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2160
Query: 391 -------KKQRKEKEKILLQKREIESKL 411
+K +K E+ L QK ++E +L
Sbjct: 2161 QAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Score = 47.0 bits (110), Expect = 4e-05
Identities = 49/216 (22%), Positives = 98/216 (45%), Gaps = 10/216 (4%)
Query: 231 YVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKR 290
++ E RR+E RL ++RA ERE E EAA +R+ + K E E K+
Sbjct: 1336 FISETLRRMEE--EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 291 EQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAAR-KGVCPPASADETFT 349
+Q ++ VR+++A E+L++LR+ + A + A A E
Sbjct: 1394 QQRMQEEV------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 350 HHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIES 409
++ ++++ + E E + L+ + + E +K+Q +E+ + L ++ + ES
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 410 KLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIR 445
+ E LA ++ + + + +L AL ++R
Sbjct: 1508 QRKRQA-EVELASRVKAEAEAAREKQRALQALEELR 1542
Score = 43.1 bits (100), Expect = 6e-04
Identities = 60/250 (24%), Positives = 107/250 (42%), Gaps = 19/250 (7%)
Query: 173 EVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYV 232
E R RL + + R L++A +A+A + L+ + E + +AA
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAER------EAKELQQRMQEEVVRREEAAVD 1410
Query: 233 GEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKRE- 291
+ ++R + ++LR A + R+AEAA E + V+ E E++R
Sbjct: 1411 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 292 -----QELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADE 346
Q L+A A+ ++ R+ Q + +R+ ++ E RK + E V A A
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR 1529
Query: 347 TFTHHLQRLRKLIKKRSE----LYEAE-ERALRVMLEGE-QEEERKRELEKKQRKEKEKI 400
LQ L +L + E L +AE ERA +V + E + + EL+ K+ EK
Sbjct: 1530 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 401 LLQKREIESK 410
+R ++ +
Sbjct: 1590 AQLERSLQEE 1599
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 177 RLLRALRLVRRLRGLSQALR-EAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEA 235
R L L +++ + +A R +AEA+ L Q L E A RLQ + +
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAE------LLQQQKELAQEQARRLQEDKE-----QM 2353
Query: 236 RRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELK 295
++L + R E R+R+ E AEA R R E+ R + + ++ Q +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA------QRFR 2407
Query: 296 AAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRL 355
A+ + ++ + + T+ V +++ LE R+ A R + + E LQ+
Sbjct: 2408 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQE 2465
Query: 356 RKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESK 410
KL++ +SE + ++ EQ + + L++ EK+ +L ++R IE +
Sbjct: 2466 AKLLQLKSEEMQT--------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2512
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/256 (25%), Positives = 102/256 (39%), Gaps = 38/256 (14%)
Query: 181 ALRLVRRLRGL---SQALRE-AEADGAAWVLLYSQTAPLRAELAERL------------- 223
AL V RL+ ++ LRE AE + A + L + A R + E+
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066
Query: 224 QPLTQAAYV-----GEA---RRRLERVRRRRLRL-RERAREREAEREAEAARAVEREQEI 274
Q L Q V GEA RR E R++ RE A+ R EAE + EQ
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126
Query: 275 DRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAA 334
R + + E K+ EQE A + +R+KQA M EK +K ++
Sbjct: 2127 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM-------EKHKKFAEQTLR 2179
Query: 335 RKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQR 394
+K A ++ T +L + +++ L E +R E ++ + E R
Sbjct: 2180 QK-----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234
Query: 395 KEKEKILLQKREIESK 410
+ E++ K IE++
Sbjct: 2235 VQMEELSKLKARIEAE 2250
Score = 38.9 bits (89), Expect = 0.011
Identities = 73/298 (24%), Positives = 119/298 (39%), Gaps = 58/298 (19%)
Query: 164 RTHAGPSLGEVRARLLRA--LRLVRRLRGLSQALREAEAD----GAAWVLLYSQTAPLRA 217
R A GE + +LL RL R +Q +E EA+ A +L + A
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776
Query: 218 ELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERARERE------AEREAEAARAV- 268
E + Q A G R E R R E R+R+ A + AEA R +
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 269 ---------------------EREQEIDRWRVKCVQEVEEKKREQEL----KAAADGVLS 303
E+E E +R R E +++R +E KA + L+
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896
Query: 304 EVRK-KQADTKRMVDILR-ALEKLRKLRKEAAARKGVCPPASADET-FTHHLQRLRK--- 357
++RK ++ +R ++ L + R++ +E A K A+A + L R+R
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956
Query: 358 ---LIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRK----EKEKILLQKREIE 408
K+++EL A +R L +EE R+RE E++ +K E+E +K +E
Sbjct: 1957 DTLRSKEQAELEAARQRQL-----AAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Score = 31.2 bits (69), Expect = 2.2
Identities = 32/145 (22%), Positives = 67/145 (46%), Gaps = 14/145 (9%)
Query: 163 QRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAER 222
Q H L E A L R +++ L Q E LL A ++ L+E+
Sbjct: 2440 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2499
Query: 223 LQPLTQAAYVGEARRRLERV------RRRRLRLRERAREREAEREA--------EAARAV 268
L + ++ + + +LE++ + ++LR ++ ++++ E+E EA R
Sbjct: 2500 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 269 EREQEIDRWRVKCVQEVEEKKREQE 293
+E R + + +Q++E+++R+QE
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQE 2584
Score = 30.8 bits (68), Expect = 2.9
Identities = 56/244 (22%), Positives = 101/244 (41%), Gaps = 25/244 (10%)
Query: 148 EAVFGTPRRAGCPVPQRTHAGPSLGEV-RARLLRALRLVRRLRGLSQALREAEADGAAWV 206
E V P + R+ +LG++ + R L A+ L +L+ +S +R + GA V
Sbjct: 1048 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQ--GAEEV 1104
Query: 207 LLYSQTAPLRAELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERAREREAEREAEA 264
L + A+ P +A A + + R + E + LR+ R + E
Sbjct: 1105 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1164
Query: 265 ARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRA-LE 323
R ER+ E++RWR + Q +E + L ++ ++ + D L A L+
Sbjct: 1165 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1224
Query: 324 KLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEE 383
R+ +++ A P A + Q +R+ +++ L E ER GE+ E
Sbjct: 1225 DARRRQEQIQA----MPLADS--------QAVREQLRQEQALLEEIER------HGEKVE 1266
Query: 384 ERKR 387
E +R
Sbjct: 1267 ECQR 1270
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 69.3 bits (168), Expect = 7e-12
Identities = 68/268 (25%), Positives = 122/268 (45%), Gaps = 13/268 (4%)
Query: 155 RRAGCPVPQRTHAGPSLGEVRARLLRALRLVR-RLRGLSQALREAEADGAAWVLLYSQTA 213
R+A + R A + R L+AL +R + + LR+AE + A V + +TA
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1538
Query: 214 PLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVER-EQ 272
AE + + + A + R L+ +LRE A ER A+++AEA RA E E+
Sbjct: 1539 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAERAREEAER 1597
Query: 273 EIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEA 332
E++RW++K + + + + +E+ +E K++ + +R E+ ++E
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1657
Query: 333 AARKGVCPPASADETFTHHLQRLRKLIKKRSELYEA-------EERALRVMLEGEQEEER 385
A ++ A+ T L ++LI+ R+E + EE R+ E ++
Sbjct: 1658 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1717
Query: 386 KRELE---KKQRKEKEKILLQKREIESK 410
++ELE K R E E +L K E +
Sbjct: 1718 RQELEAELAKVRAEMEVLLASKARAEEE 1745
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/224 (26%), Positives = 97/224 (43%), Gaps = 19/224 (8%)
Query: 193 QALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRR-LERVRRRRLRLRE 251
+A EAE + W L ++ LR + E Q + A E ++ ER RRR + E
Sbjct: 1590 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1649
Query: 252 RA-RERE-AEREAEAARAVER---------EQEIDRWRVKCVQEVEEKKREQELKAAADG 300
+A R+RE AE+E E R + EQE+ R R E ++ EQ+ + +
Sbjct: 1650 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEE 1703
Query: 301 VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK 360
+ R+ A T++ ++ L K+R + A K S T QRL
Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR-STSEKSKQRLEAEAG 1762
Query: 361 KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQK 404
+ EL E R + E +++ + E +QR E E++L +K
Sbjct: 1763 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1806
Score = 49.7 bits (117), Expect = 6e-06
Identities = 61/268 (22%), Positives = 111/268 (41%), Gaps = 52/268 (19%)
Query: 196 REAEADGAAWVLLYSQTAPLRAELA---ERLQPLTQAAYVGEARRRLERVRRRRLRLRER 252
R+ E + A + + A +AEL R++ + + + LE R+R+L E
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1948
Query: 253 AREREAEREAEAARAVERE---------QEIDRWRVK--------------------CVQ 283
R REAE + + A E E +E++R + K Q
Sbjct: 1949 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008
Query: 284 EVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRAL----EKLRKLRKEA-AARKGV 338
E +K+ + E KA A V + ++ Q ++ +L L E R+ +EA AR
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2068
Query: 339 CPPASADETFTHHLQRLRKLIKKRSEL-YEAEERALRVMLEGEQEEERKRELE------- 390
A+ +RL++ +++++ +A+ A ++ E EQE R+ + E
Sbjct: 2069 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2128
Query: 391 -------KKQRKEKEKILLQKREIESKL 411
+K +K E+ L QK ++E +L
Sbjct: 2129 QAADAEMEKHKKFAEQTLRQKAQVEQEL 2156
Score = 47.0 bits (110), Expect = 4e-05
Identities = 49/216 (22%), Positives = 98/216 (45%), Gaps = 10/216 (4%)
Query: 231 YVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKR 290
++ E RR+E RL ++RA ERE E EAA +R+ + K E E K+
Sbjct: 1304 FISETLRRMEE--EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1361
Query: 291 EQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAAR-KGVCPPASADETFT 349
+Q ++ VR+++A E+L++LR+ + A + A A E
Sbjct: 1362 QQRMQEEV------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415
Query: 350 HHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIES 409
++ ++++ + E E + L+ + + E +K+Q +E+ + L ++ + ES
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475
Query: 410 KLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIR 445
+ E LA ++ + + + +L AL ++R
Sbjct: 1476 QRKRQA-EVELASRVKAEAEAAREKQRALQALEELR 1510
Score = 43.1 bits (100), Expect = 6e-04
Identities = 60/250 (24%), Positives = 107/250 (42%), Gaps = 19/250 (7%)
Query: 173 EVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYV 232
E R RL + + R L++A +A+A + L+ + E + +AA
Sbjct: 1325 EERERLAEVEAALEKQRQLAEAHAQAKAQAER------EAKELQQRMQEEVVRREEAAVD 1378
Query: 233 GEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKRE- 291
+ ++R + ++LR A + R+AEAA E + V+ E E++R
Sbjct: 1379 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1438
Query: 292 -----QELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADE 346
Q L+A A+ ++ R+ Q + +R+ ++ E RK + E V A A
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR 1497
Query: 347 TFTHHLQRLRKLIKKRSE----LYEAE-ERALRVMLEGE-QEEERKRELEKKQRKEKEKI 400
LQ L +L + E L +AE ERA +V + E + + EL+ K+ EK
Sbjct: 1498 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1557
Query: 401 LLQKREIESK 410
+R ++ +
Sbjct: 1558 AQLERSLQEE 1567
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 177 RLLRALRLVRRLRGLSQALR-EAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEA 235
R L L +++ + +A R +AEA+ L Q L E A RLQ + +
Sbjct: 2273 RALAEKMLKEKMQAVQEATRLKAEAE------LLQQQKELAQEQARRLQEDKE-----QM 2321
Query: 236 RRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELK 295
++L + R E R+R+ E AEA R R E+ R + + ++ Q +
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA------QRFR 2375
Query: 296 AAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRL 355
A+ + ++ + + T+ V +++ LE R+ A R + + E LQ+
Sbjct: 2376 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQE 2433
Query: 356 RKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESK 410
KL++ +SE + ++ EQ + + L++ EK+ +L ++R IE +
Sbjct: 2434 AKLLQLKSEEMQT--------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2480
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/256 (25%), Positives = 102/256 (39%), Gaps = 38/256 (14%)
Query: 181 ALRLVRRLRGL---SQALRE-AEADGAAWVLLYSQTAPLRAELAERL------------- 223
AL V RL+ ++ LRE AE + A + L + A R + E+
Sbjct: 1975 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034
Query: 224 QPLTQAAYV-----GEA---RRRLERVRRRRLRL-RERAREREAEREAEAARAVEREQEI 274
Q L Q V GEA RR E R++ RE A+ R EAE + EQ
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2094
Query: 275 DRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAA 334
R + + E K+ EQE A + +R+KQA M EK +K ++
Sbjct: 2095 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM-------EKHKKFAEQTLR 2147
Query: 335 RKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQR 394
+K A ++ T +L + +++ L E +R E ++ + E R
Sbjct: 2148 QK-----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202
Query: 395 KEKEKILLQKREIESK 410
+ E++ K IE++
Sbjct: 2203 VQMEELSKLKARIEAE 2218
Score = 38.9 bits (89), Expect = 0.011
Identities = 73/298 (24%), Positives = 119/298 (39%), Gaps = 58/298 (19%)
Query: 164 RTHAGPSLGEVRARLLRA--LRLVRRLRGLSQALREAEAD----GAAWVLLYSQTAPLRA 217
R A GE + +LL RL R +Q +E EA+ A +L + A
Sbjct: 1685 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1744
Query: 218 ELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERARERE------AEREAEAARAV- 268
E + Q A G R E R R E R+R+ A + AEA R +
Sbjct: 1745 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1804
Query: 269 ---------------------EREQEIDRWRVKCVQEVEEKKREQEL----KAAADGVLS 303
E+E E +R R E +++R +E KA + L+
Sbjct: 1805 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1864
Query: 304 EVRK-KQADTKRMVDILR-ALEKLRKLRKEAAARKGVCPPASADET-FTHHLQRLRK--- 357
++RK ++ +R ++ L + R++ +E A K A+A + L R+R
Sbjct: 1865 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1924
Query: 358 ---LIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRK----EKEKILLQKREIE 408
K+++EL A +R L +EE R+RE E++ +K E+E +K +E
Sbjct: 1925 DTLRSKEQAELEAARQRQL-----AAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977
Score = 31.2 bits (69), Expect = 2.2
Identities = 32/145 (22%), Positives = 67/145 (46%), Gaps = 14/145 (9%)
Query: 163 QRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAER 222
Q H L E A L R +++ L Q E LL A ++ L+E+
Sbjct: 2408 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2467
Query: 223 LQPLTQAAYVGEARRRLERV------RRRRLRLRERAREREAEREA--------EAARAV 268
L + ++ + + +LE++ + ++LR ++ ++++ E+E EA R
Sbjct: 2468 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2527
Query: 269 EREQEIDRWRVKCVQEVEEKKREQE 293
+E R + + +Q++E+++R+QE
Sbjct: 2528 HEAEEGVRRKQEELQQLEQQRRQQE 2552
Score = 30.8 bits (68), Expect = 2.9
Identities = 56/244 (22%), Positives = 101/244 (41%), Gaps = 25/244 (10%)
Query: 148 EAVFGTPRRAGCPVPQRTHAGPSLGEV-RARLLRALRLVRRLRGLSQALREAEADGAAWV 206
E V P + R+ +LG++ + R L A+ L +L+ +S +R + GA V
Sbjct: 1016 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQ--GAEEV 1072
Query: 207 LLYSQTAPLRAELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERAREREAEREAEA 264
L + A+ P +A A + + R + E + LR+ R + E
Sbjct: 1073 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1132
Query: 265 ARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRA-LE 323
R ER+ E++RWR + Q +E + L ++ ++ + D L A L+
Sbjct: 1133 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1192
Query: 324 KLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEE 383
R+ +++ A P A + Q +R+ +++ L E ER GE+ E
Sbjct: 1193 DARRRQEQIQA----MPLADS--------QAVREQLRQEQALLEEIER------HGEKVE 1234
Query: 384 ERKR 387
E +R
Sbjct: 1235 ECQR 1238
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 69.3 bits (168), Expect = 7e-12
Identities = 68/268 (25%), Positives = 122/268 (45%), Gaps = 13/268 (4%)
Query: 155 RRAGCPVPQRTHAGPSLGEVRARLLRALRLVR-RLRGLSQALREAEADGAAWVLLYSQTA 213
R+A + R A + R L+AL +R + + LR+AE + A V + +TA
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1707
Query: 214 PLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVER-EQ 272
AE + + + A + R L+ +LRE A ER A+++AEA RA E E+
Sbjct: 1708 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAERAREEAER 1766
Query: 273 EIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEA 332
E++RW++K + + + + +E+ +E K++ + +R E+ ++E
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1826
Query: 333 AARKGVCPPASADETFTHHLQRLRKLIKKRSELYEA-------EERALRVMLEGEQEEER 385
A ++ A+ T L ++LI+ R+E + EE R+ E ++
Sbjct: 1827 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886
Query: 386 KRELE---KKQRKEKEKILLQKREIESK 410
++ELE K R E E +L K E +
Sbjct: 1887 RQELEAELAKVRAEMEVLLASKARAEEE 1914
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/224 (26%), Positives = 97/224 (43%), Gaps = 19/224 (8%)
Query: 193 QALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRR-LERVRRRRLRLRE 251
+A EAE + W L ++ LR + E Q + A E ++ ER RRR + E
Sbjct: 1759 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1818
Query: 252 RA-RERE-AEREAEAARAVER---------EQEIDRWRVKCVQEVEEKKREQELKAAADG 300
+A R+RE AE+E E R + EQE+ R R E ++ EQ+ + +
Sbjct: 1819 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEE 1872
Query: 301 VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK 360
+ R+ A T++ ++ L K+R + A K S T QRL
Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR-STSEKSKQRLEAEAG 1931
Query: 361 KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQK 404
+ EL E R + E +++ + E +QR E E++L +K
Sbjct: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1975
Score = 49.7 bits (117), Expect = 6e-06
Identities = 61/268 (22%), Positives = 111/268 (41%), Gaps = 52/268 (19%)
Query: 196 REAEADGAAWVLLYSQTAPLRAELA---ERLQPLTQAAYVGEARRRLERVRRRRLRLRER 252
R+ E + A + + A +AEL R++ + + + LE R+R+L E
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117
Query: 253 AREREAEREAEAARAVERE---------QEIDRWRVK--------------------CVQ 283
R REAE + + A E E +E++R + K Q
Sbjct: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177
Query: 284 EVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRAL----EKLRKLRKEA-AARKGV 338
E +K+ + E KA A V + ++ Q ++ +L L E R+ +EA AR
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2237
Query: 339 CPPASADETFTHHLQRLRKLIKKRSEL-YEAEERALRVMLEGEQEEERKRELE------- 390
A+ +RL++ +++++ +A+ A ++ E EQE R+ + E
Sbjct: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297
Query: 391 -------KKQRKEKEKILLQKREIESKL 411
+K +K E+ L QK ++E +L
Sbjct: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQEL 2325
Score = 47.0 bits (110), Expect = 4e-05
Identities = 49/216 (22%), Positives = 98/216 (45%), Gaps = 10/216 (4%)
Query: 231 YVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKR 290
++ E RR+E RL ++RA ERE E EAA +R+ + K E E K+
Sbjct: 1473 FISETLRRMEE--EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1530
Query: 291 EQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAAR-KGVCPPASADETFT 349
+Q ++ VR+++A E+L++LR+ + A + A A E
Sbjct: 1531 QQRMQEEV------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584
Query: 350 HHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIES 409
++ ++++ + E E + L+ + + E +K+Q +E+ + L ++ + ES
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644
Query: 410 KLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIR 445
+ E LA ++ + + + +L AL ++R
Sbjct: 1645 QRKRQA-EVELASRVKAEAEAAREKQRALQALEELR 1679
Score = 43.1 bits (100), Expect = 6e-04
Identities = 60/250 (24%), Positives = 107/250 (42%), Gaps = 19/250 (7%)
Query: 173 EVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYV 232
E R RL + + R L++A +A+A + L+ + E + +AA
Sbjct: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAER------EAKELQQRMQEEVVRREEAAVD 1547
Query: 233 GEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKRE- 291
+ ++R + ++LR A + R+AEAA E + V+ E E++R
Sbjct: 1548 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1607
Query: 292 -----QELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADE 346
Q L+A A+ ++ R+ Q + +R+ ++ E RK + E V A A
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR 1666
Query: 347 TFTHHLQRLRKLIKKRSE----LYEAE-ERALRVMLEGE-QEEERKRELEKKQRKEKEKI 400
LQ L +L + E L +AE ERA +V + E + + EL+ K+ EK
Sbjct: 1667 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1726
Query: 401 LLQKREIESK 410
+R ++ +
Sbjct: 1727 AQLERSLQEE 1736
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 177 RLLRALRLVRRLRGLSQALR-EAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEA 235
R L L +++ + +A R +AEA+ L Q L E A RLQ + +
Sbjct: 2442 RALAEKMLKEKMQAVQEATRLKAEAE------LLQQQKELAQEQARRLQEDKE-----QM 2490
Query: 236 RRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELK 295
++L + R E R+R+ E AEA R R E+ R + + ++ Q +
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA------QRFR 2544
Query: 296 AAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRL 355
A+ + ++ + + T+ V +++ LE R+ A R + + E LQ+
Sbjct: 2545 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQE 2602
Query: 356 RKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESK 410
KL++ +SE + ++ EQ + + L++ EK+ +L ++R IE +
Sbjct: 2603 AKLLQLKSEEMQT--------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2649
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/256 (25%), Positives = 102/256 (39%), Gaps = 38/256 (14%)
Query: 181 ALRLVRRLRGL---SQALRE-AEADGAAWVLLYSQTAPLRAELAERL------------- 223
AL V RL+ ++ LRE AE + A + L + A R + E+
Sbjct: 2144 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203
Query: 224 QPLTQAAYV-----GEA---RRRLERVRRRRLRL-RERAREREAEREAEAARAVEREQEI 274
Q L Q V GEA RR E R++ RE A+ R EAE + EQ
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2263
Query: 275 DRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAA 334
R + + E K+ EQE A + +R+KQA M EK +K ++
Sbjct: 2264 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM-------EKHKKFAEQTLR 2316
Query: 335 RKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQR 394
+K A ++ T +L + +++ L E +R E ++ + E R
Sbjct: 2317 QK-----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371
Query: 395 KEKEKILLQKREIESK 410
+ E++ K IE++
Sbjct: 2372 VQMEELSKLKARIEAE 2387
Score = 38.9 bits (89), Expect = 0.011
Identities = 73/298 (24%), Positives = 119/298 (39%), Gaps = 58/298 (19%)
Query: 164 RTHAGPSLGEVRARLLRA--LRLVRRLRGLSQALREAEAD----GAAWVLLYSQTAPLRA 217
R A GE + +LL RL R +Q +E EA+ A +L + A
Sbjct: 1854 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1913
Query: 218 ELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERARERE------AEREAEAARAV- 268
E + Q A G R E R R E R+R+ A + AEA R +
Sbjct: 1914 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1973
Query: 269 ---------------------EREQEIDRWRVKCVQEVEEKKREQEL----KAAADGVLS 303
E+E E +R R E +++R +E KA + L+
Sbjct: 1974 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 2033
Query: 304 EVRK-KQADTKRMVDILR-ALEKLRKLRKEAAARKGVCPPASADET-FTHHLQRLRK--- 357
++RK ++ +R ++ L + R++ +E A K A+A + L R+R
Sbjct: 2034 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 2093
Query: 358 ---LIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRK----EKEKILLQKREIE 408
K+++EL A +R L +EE R+RE E++ +K E+E +K +E
Sbjct: 2094 DTLRSKEQAELEAARQRQL-----AAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146
Score = 31.2 bits (69), Expect = 2.2
Identities = 32/145 (22%), Positives = 67/145 (46%), Gaps = 14/145 (9%)
Query: 163 QRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAER 222
Q H L E A L R +++ L Q E LL A ++ L+E+
Sbjct: 2577 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2636
Query: 223 LQPLTQAAYVGEARRRLERV------RRRRLRLRERAREREAEREA--------EAARAV 268
L + ++ + + +LE++ + ++LR ++ ++++ E+E EA R
Sbjct: 2637 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2696
Query: 269 EREQEIDRWRVKCVQEVEEKKREQE 293
+E R + + +Q++E+++R+QE
Sbjct: 2697 HEAEEGVRRKQEELQQLEQQRRQQE 2721
Score = 30.8 bits (68), Expect = 2.9
Identities = 56/244 (22%), Positives = 101/244 (41%), Gaps = 25/244 (10%)
Query: 148 EAVFGTPRRAGCPVPQRTHAGPSLGEV-RARLLRALRLVRRLRGLSQALREAEADGAAWV 206
E V P + R+ +LG++ + R L A+ L +L+ +S +R + GA V
Sbjct: 1185 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQ--GAEEV 1241
Query: 207 LLYSQTAPLRAELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERAREREAEREAEA 264
L + A+ P +A A + + R + E + LR+ R + E
Sbjct: 1242 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1301
Query: 265 ARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRA-LE 323
R ER+ E++RWR + Q +E + L ++ ++ + D L A L+
Sbjct: 1302 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1361
Query: 324 KLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEE 383
R+ +++ A P A + Q +R+ +++ L E ER GE+ E
Sbjct: 1362 DARRRQEQIQA----MPLADS--------QAVREQLRQEQALLEEIER------HGEKVE 1403
Query: 384 ERKR 387
E +R
Sbjct: 1404 ECQR 1407
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 69.3 bits (168), Expect = 7e-12
Identities = 68/268 (25%), Positives = 122/268 (45%), Gaps = 13/268 (4%)
Query: 155 RRAGCPVPQRTHAGPSLGEVRARLLRALRLVR-RLRGLSQALREAEADGAAWVLLYSQTA 213
R+A + R A + R L+AL +R + + LR+AE + A V + +TA
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1548
Query: 214 PLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVER-EQ 272
AE + + + A + R L+ +LRE A ER A+++AEA RA E E+
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAERAREEAER 1607
Query: 273 EIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEA 332
E++RW++K + + + + +E+ +E K++ + +R E+ ++E
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1667
Query: 333 AARKGVCPPASADETFTHHLQRLRKLIKKRSELYEA-------EERALRVMLEGEQEEER 385
A ++ A+ T L ++LI+ R+E + EE R+ E ++
Sbjct: 1668 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727
Query: 386 KRELE---KKQRKEKEKILLQKREIESK 410
++ELE K R E E +L K E +
Sbjct: 1728 RQELEAELAKVRAEMEVLLASKARAEEE 1755
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/224 (26%), Positives = 97/224 (43%), Gaps = 19/224 (8%)
Query: 193 QALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRR-LERVRRRRLRLRE 251
+A EAE + W L ++ LR + E Q + A E ++ ER RRR + E
Sbjct: 1600 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1659
Query: 252 RA-RERE-AEREAEAARAVER---------EQEIDRWRVKCVQEVEEKKREQELKAAADG 300
+A R+RE AE+E E R + EQE+ R R E ++ EQ+ + +
Sbjct: 1660 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEE 1713
Query: 301 VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK 360
+ R+ A T++ ++ L K+R + A K S T QRL
Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR-STSEKSKQRLEAEAG 1772
Query: 361 KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQK 404
+ EL E R + E +++ + E +QR E E++L +K
Sbjct: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1816
Score = 49.7 bits (117), Expect = 6e-06
Identities = 61/268 (22%), Positives = 111/268 (41%), Gaps = 52/268 (19%)
Query: 196 REAEADGAAWVLLYSQTAPLRAELA---ERLQPLTQAAYVGEARRRLERVRRRRLRLRER 252
R+ E + A + + A +AEL R++ + + + LE R+R+L E
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
Query: 253 AREREAEREAEAARAVERE---------QEIDRWRVK--------------------CVQ 283
R REAE + + A E E +E++R + K Q
Sbjct: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
Query: 284 EVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRAL----EKLRKLRKEA-AARKGV 338
E +K+ + E KA A V + ++ Q ++ +L L E R+ +EA AR
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2078
Query: 339 CPPASADETFTHHLQRLRKLIKKRSEL-YEAEERALRVMLEGEQEEERKRELE------- 390
A+ +RL++ +++++ +A+ A ++ E EQE R+ + E
Sbjct: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138
Query: 391 -------KKQRKEKEKILLQKREIESKL 411
+K +K E+ L QK ++E +L
Sbjct: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQEL 2166
Score = 47.0 bits (110), Expect = 4e-05
Identities = 49/216 (22%), Positives = 98/216 (45%), Gaps = 10/216 (4%)
Query: 231 YVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKR 290
++ E RR+E RL ++RA ERE E EAA +R+ + K E E K+
Sbjct: 1314 FISETLRRMEE--EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1371
Query: 291 EQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAAR-KGVCPPASADETFT 349
+Q ++ VR+++A E+L++LR+ + A + A A E
Sbjct: 1372 QQRMQEEV------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425
Query: 350 HHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIES 409
++ ++++ + E E + L+ + + E +K+Q +E+ + L ++ + ES
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1485
Query: 410 KLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIR 445
+ E LA ++ + + + +L AL ++R
Sbjct: 1486 QRKRQA-EVELASRVKAEAEAAREKQRALQALEELR 1520
Score = 43.1 bits (100), Expect = 6e-04
Identities = 60/250 (24%), Positives = 107/250 (42%), Gaps = 19/250 (7%)
Query: 173 EVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYV 232
E R RL + + R L++A +A+A + L+ + E + +AA
Sbjct: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAER------EAKELQQRMQEEVVRREEAAVD 1388
Query: 233 GEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKRE- 291
+ ++R + ++LR A + R+AEAA E + V+ E E++R
Sbjct: 1389 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1448
Query: 292 -----QELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADE 346
Q L+A A+ ++ R+ Q + +R+ ++ E RK + E V A A
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR 1507
Query: 347 TFTHHLQRLRKLIKKRSE----LYEAE-ERALRVMLEGE-QEEERKRELEKKQRKEKEKI 400
LQ L +L + E L +AE ERA +V + E + + EL+ K+ EK
Sbjct: 1508 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1567
Query: 401 LLQKREIESK 410
+R ++ +
Sbjct: 1568 AQLERSLQEE 1577
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 177 RLLRALRLVRRLRGLSQALR-EAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEA 235
R L L +++ + +A R +AEA+ L Q L E A RLQ + +
Sbjct: 2283 RALAEKMLKEKMQAVQEATRLKAEAE------LLQQQKELAQEQARRLQEDKE-----QM 2331
Query: 236 RRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELK 295
++L + R E R+R+ E AEA R R E+ R + + ++ Q +
Sbjct: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA------QRFR 2385
Query: 296 AAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRL 355
A+ + ++ + + T+ V +++ LE R+ A R + + E LQ+
Sbjct: 2386 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQE 2443
Query: 356 RKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESK 410
KL++ +SE + ++ EQ + + L++ EK+ +L ++R IE +
Sbjct: 2444 AKLLQLKSEEMQT--------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2490
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/256 (25%), Positives = 102/256 (39%), Gaps = 38/256 (14%)
Query: 181 ALRLVRRLRGL---SQALRE-AEADGAAWVLLYSQTAPLRAELAERL------------- 223
AL V RL+ ++ LRE AE + A + L + A R + E+
Sbjct: 1985 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044
Query: 224 QPLTQAAYV-----GEA---RRRLERVRRRRLRL-RERAREREAEREAEAARAVEREQEI 274
Q L Q V GEA RR E R++ RE A+ R EAE + EQ
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2104
Query: 275 DRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAA 334
R + + E K+ EQE A + +R+KQA M EK +K ++
Sbjct: 2105 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM-------EKHKKFAEQTLR 2157
Query: 335 RKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQR 394
+K A ++ T +L + +++ L E +R E ++ + E R
Sbjct: 2158 QK-----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
Query: 395 KEKEKILLQKREIESK 410
+ E++ K IE++
Sbjct: 2213 VQMEELSKLKARIEAE 2228
Score = 38.9 bits (89), Expect = 0.011
Identities = 73/298 (24%), Positives = 119/298 (39%), Gaps = 58/298 (19%)
Query: 164 RTHAGPSLGEVRARLLRA--LRLVRRLRGLSQALREAEAD----GAAWVLLYSQTAPLRA 217
R A GE + +LL RL R +Q +E EA+ A +L + A
Sbjct: 1695 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
Query: 218 ELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERARERE------AEREAEAARAV- 268
E + Q A G R E R R E R+R+ A + AEA R +
Sbjct: 1755 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1814
Query: 269 ---------------------EREQEIDRWRVKCVQEVEEKKREQEL----KAAADGVLS 303
E+E E +R R E +++R +E KA + L+
Sbjct: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874
Query: 304 EVRK-KQADTKRMVDILR-ALEKLRKLRKEAAARKGVCPPASADET-FTHHLQRLRK--- 357
++RK ++ +R ++ L + R++ +E A K A+A + L R+R
Sbjct: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1934
Query: 358 ---LIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRK----EKEKILLQKREIE 408
K+++EL A +R L +EE R+RE E++ +K E+E +K +E
Sbjct: 1935 DTLRSKEQAELEAARQRQL-----AAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987
Score = 31.2 bits (69), Expect = 2.2
Identities = 32/145 (22%), Positives = 67/145 (46%), Gaps = 14/145 (9%)
Query: 163 QRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAER 222
Q H L E A L R +++ L Q E LL A ++ L+E+
Sbjct: 2418 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2477
Query: 223 LQPLTQAAYVGEARRRLERV------RRRRLRLRERAREREAEREA--------EAARAV 268
L + ++ + + +LE++ + ++LR ++ ++++ E+E EA R
Sbjct: 2478 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2537
Query: 269 EREQEIDRWRVKCVQEVEEKKREQE 293
+E R + + +Q++E+++R+QE
Sbjct: 2538 HEAEEGVRRKQEELQQLEQQRRQQE 2562
Score = 30.8 bits (68), Expect = 2.9
Identities = 56/244 (22%), Positives = 101/244 (41%), Gaps = 25/244 (10%)
Query: 148 EAVFGTPRRAGCPVPQRTHAGPSLGEV-RARLLRALRLVRRLRGLSQALREAEADGAAWV 206
E V P + R+ +LG++ + R L A+ L +L+ +S +R + GA V
Sbjct: 1026 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQ--GAEEV 1082
Query: 207 LLYSQTAPLRAELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERAREREAEREAEA 264
L + A+ P +A A + + R + E + LR+ R + E
Sbjct: 1083 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1142
Query: 265 ARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRA-LE 323
R ER+ E++RWR + Q +E + L ++ ++ + D L A L+
Sbjct: 1143 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1202
Query: 324 KLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEE 383
R+ +++ A P A + Q +R+ +++ L E ER GE+ E
Sbjct: 1203 DARRRQEQIQA----MPLADS--------QAVREQLRQEQALLEEIER------HGEKVE 1244
Query: 384 ERKR 387
E +R
Sbjct: 1245 ECQR 1248
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 69.3 bits (168), Expect = 7e-12
Identities = 68/268 (25%), Positives = 122/268 (45%), Gaps = 13/268 (4%)
Query: 155 RRAGCPVPQRTHAGPSLGEVRARLLRALRLVR-RLRGLSQALREAEADGAAWVLLYSQTA 213
R+A + R A + R L+AL +R + + LR+AE + A V + +TA
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1556
Query: 214 PLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVER-EQ 272
AE + + + A + R L+ +LRE A ER A+++AEA RA E E+
Sbjct: 1557 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAERAREEAER 1615
Query: 273 EIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEA 332
E++RW++K + + + + +E+ +E K++ + +R E+ ++E
Sbjct: 1616 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1675
Query: 333 AARKGVCPPASADETFTHHLQRLRKLIKKRSELYEA-------EERALRVMLEGEQEEER 385
A ++ A+ T L ++LI+ R+E + EE R+ E ++
Sbjct: 1676 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1735
Query: 386 KRELE---KKQRKEKEKILLQKREIESK 410
++ELE K R E E +L K E +
Sbjct: 1736 RQELEAELAKVRAEMEVLLASKARAEEE 1763
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/224 (26%), Positives = 97/224 (43%), Gaps = 19/224 (8%)
Query: 193 QALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRR-LERVRRRRLRLRE 251
+A EAE + W L ++ LR + E Q + A E ++ ER RRR + E
Sbjct: 1608 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1667
Query: 252 RA-RERE-AEREAEAARAVER---------EQEIDRWRVKCVQEVEEKKREQELKAAADG 300
+A R+RE AE+E E R + EQE+ R R E ++ EQ+ + +
Sbjct: 1668 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEE 1721
Query: 301 VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK 360
+ R+ A T++ ++ L K+R + A K S T QRL
Sbjct: 1722 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR-STSEKSKQRLEAEAG 1780
Query: 361 KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQK 404
+ EL E R + E +++ + E +QR E E++L +K
Sbjct: 1781 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1824
Score = 49.7 bits (117), Expect = 6e-06
Identities = 61/268 (22%), Positives = 111/268 (41%), Gaps = 52/268 (19%)
Query: 196 REAEADGAAWVLLYSQTAPLRAELA---ERLQPLTQAAYVGEARRRLERVRRRRLRLRER 252
R+ E + A + + A +AEL R++ + + + LE R+R+L E
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1966
Query: 253 AREREAEREAEAARAVERE---------QEIDRWRVK--------------------CVQ 283
R REAE + + A E E +E++R + K Q
Sbjct: 1967 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026
Query: 284 EVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRAL----EKLRKLRKEA-AARKGV 338
E +K+ + E KA A V + ++ Q ++ +L L E R+ +EA AR
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2086
Query: 339 CPPASADETFTHHLQRLRKLIKKRSEL-YEAEERALRVMLEGEQEEERKRELE------- 390
A+ +RL++ +++++ +A+ A ++ E EQE R+ + E
Sbjct: 2087 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2146
Query: 391 -------KKQRKEKEKILLQKREIESKL 411
+K +K E+ L QK ++E +L
Sbjct: 2147 QAADAEMEKHKKFAEQTLRQKAQVEQEL 2174
Score = 47.0 bits (110), Expect = 4e-05
Identities = 49/216 (22%), Positives = 98/216 (45%), Gaps = 10/216 (4%)
Query: 231 YVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKR 290
++ E RR+E RL ++RA ERE E EAA +R+ + K E E K+
Sbjct: 1322 FISETLRRMEE--EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1379
Query: 291 EQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAAR-KGVCPPASADETFT 349
+Q ++ VR+++A E+L++LR+ + A + A A E
Sbjct: 1380 QQRMQEEV------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1433
Query: 350 HHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIES 409
++ ++++ + E E + L+ + + E +K+Q +E+ + L ++ + ES
Sbjct: 1434 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1493
Query: 410 KLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIR 445
+ E LA ++ + + + +L AL ++R
Sbjct: 1494 QRKRQA-EVELASRVKAEAEAAREKQRALQALEELR 1528
Score = 43.1 bits (100), Expect = 6e-04
Identities = 60/250 (24%), Positives = 107/250 (42%), Gaps = 19/250 (7%)
Query: 173 EVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYV 232
E R RL + + R L++A +A+A + L+ + E + +AA
Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAER------EAKELQQRMQEEVVRREEAAVD 1396
Query: 233 GEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKRE- 291
+ ++R + ++LR A + R+AEAA E + V+ E E++R
Sbjct: 1397 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1456
Query: 292 -----QELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADE 346
Q L+A A+ ++ R+ Q + +R+ ++ E RK + E V A A
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR 1515
Query: 347 TFTHHLQRLRKLIKKRSE----LYEAE-ERALRVMLEGE-QEEERKRELEKKQRKEKEKI 400
LQ L +L + E L +AE ERA +V + E + + EL+ K+ EK
Sbjct: 1516 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1575
Query: 401 LLQKREIESK 410
+R ++ +
Sbjct: 1576 AQLERSLQEE 1585
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 177 RLLRALRLVRRLRGLSQALR-EAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEA 235
R L L +++ + +A R +AEA+ L Q L E A RLQ + +
Sbjct: 2291 RALAEKMLKEKMQAVQEATRLKAEAE------LLQQQKELAQEQARRLQEDKE-----QM 2339
Query: 236 RRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELK 295
++L + R E R+R+ E AEA R R E+ R + + ++ Q +
Sbjct: 2340 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA------QRFR 2393
Query: 296 AAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRL 355
A+ + ++ + + T+ V +++ LE R+ A R + + E LQ+
Sbjct: 2394 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQE 2451
Query: 356 RKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESK 410
KL++ +SE + ++ EQ + + L++ EK+ +L ++R IE +
Sbjct: 2452 AKLLQLKSEEMQT--------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2498
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/256 (25%), Positives = 102/256 (39%), Gaps = 38/256 (14%)
Query: 181 ALRLVRRLRGL---SQALRE-AEADGAAWVLLYSQTAPLRAELAERL------------- 223
AL V RL+ ++ LRE AE + A + L + A R + E+
Sbjct: 1993 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052
Query: 224 QPLTQAAYV-----GEA---RRRLERVRRRRLRL-RERAREREAEREAEAARAVEREQEI 274
Q L Q V GEA RR E R++ RE A+ R EAE + EQ
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2112
Query: 275 DRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAA 334
R + + E K+ EQE A + +R+KQA M EK +K ++
Sbjct: 2113 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM-------EKHKKFAEQTLR 2165
Query: 335 RKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQR 394
+K A ++ T +L + +++ L E +R E ++ + E R
Sbjct: 2166 QK-----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220
Query: 395 KEKEKILLQKREIESK 410
+ E++ K IE++
Sbjct: 2221 VQMEELSKLKARIEAE 2236
Score = 38.9 bits (89), Expect = 0.011
Identities = 73/298 (24%), Positives = 119/298 (39%), Gaps = 58/298 (19%)
Query: 164 RTHAGPSLGEVRARLLRA--LRLVRRLRGLSQALREAEAD----GAAWVLLYSQTAPLRA 217
R A GE + +LL RL R +Q +E EA+ A +L + A
Sbjct: 1703 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762
Query: 218 ELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERARERE------AEREAEAARAV- 268
E + Q A G R E R R E R+R+ A + AEA R +
Sbjct: 1763 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1822
Query: 269 ---------------------EREQEIDRWRVKCVQEVEEKKREQEL----KAAADGVLS 303
E+E E +R R E +++R +E KA + L+
Sbjct: 1823 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1882
Query: 304 EVRK-KQADTKRMVDILR-ALEKLRKLRKEAAARKGVCPPASADET-FTHHLQRLRK--- 357
++RK ++ +R ++ L + R++ +E A K A+A + L R+R
Sbjct: 1883 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1942
Query: 358 ---LIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRK----EKEKILLQKREIE 408
K+++EL A +R L +EE R+RE E++ +K E+E +K +E
Sbjct: 1943 DTLRSKEQAELEAARQRQL-----AAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995
Score = 31.2 bits (69), Expect = 2.2
Identities = 32/145 (22%), Positives = 67/145 (46%), Gaps = 14/145 (9%)
Query: 163 QRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAER 222
Q H L E A L R +++ L Q E LL A ++ L+E+
Sbjct: 2426 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2485
Query: 223 LQPLTQAAYVGEARRRLERV------RRRRLRLRERAREREAEREA--------EAARAV 268
L + ++ + + +LE++ + ++LR ++ ++++ E+E EA R
Sbjct: 2486 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2545
Query: 269 EREQEIDRWRVKCVQEVEEKKREQE 293
+E R + + +Q++E+++R+QE
Sbjct: 2546 HEAEEGVRRKQEELQQLEQQRRQQE 2570
Score = 30.8 bits (68), Expect = 2.9
Identities = 56/244 (22%), Positives = 101/244 (41%), Gaps = 25/244 (10%)
Query: 148 EAVFGTPRRAGCPVPQRTHAGPSLGEV-RARLLRALRLVRRLRGLSQALREAEADGAAWV 206
E V P + R+ +LG++ + R L A+ L +L+ +S +R + GA V
Sbjct: 1034 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQ--GAEEV 1090
Query: 207 LLYSQTAPLRAELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERAREREAEREAEA 264
L + A+ P +A A + + R + E + LR+ R + E
Sbjct: 1091 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1150
Query: 265 ARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRA-LE 323
R ER+ E++RWR + Q +E + L ++ ++ + D L A L+
Sbjct: 1151 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1210
Query: 324 KLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEE 383
R+ +++ A P A + Q +R+ +++ L E ER GE+ E
Sbjct: 1211 DARRRQEQIQA----MPLADS--------QAVREQLRQEQALLEEIER------HGEKVE 1252
Query: 384 ERKR 387
E +R
Sbjct: 1253 ECQR 1256
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 69.3 bits (168), Expect = 7e-12
Identities = 68/268 (25%), Positives = 122/268 (45%), Gaps = 13/268 (4%)
Query: 155 RRAGCPVPQRTHAGPSLGEVRARLLRALRLVR-RLRGLSQALREAEADGAAWVLLYSQTA 213
R+A + R A + R L+AL +R + + LR+AE + A V + +TA
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA 1597
Query: 214 PLRAELAERLQPLTQAAYVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVER-EQ 272
AE + + + A + R L+ +LRE A ER A+++AEA RA E E+
Sbjct: 1598 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA-ERRAQQQAEAERAREEAER 1656
Query: 273 EIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEA 332
E++RW++K + + + + +E+ +E K++ + +R E+ ++E
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716
Query: 333 AARKGVCPPASADETFTHHLQRLRKLIKKRSELYEA-------EERALRVMLEGEQEEER 385
A ++ A+ T L ++LI+ R+E + EE R+ E ++
Sbjct: 1717 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
Query: 386 KRELE---KKQRKEKEKILLQKREIESK 410
++ELE K R E E +L K E +
Sbjct: 1777 RQELEAELAKVRAEMEVLLASKARAEEE 1804
Score = 50.4 bits (119), Expect = 4e-06
Identities = 60/224 (26%), Positives = 97/224 (43%), Gaps = 19/224 (8%)
Query: 193 QALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEARRR-LERVRRRRLRLRE 251
+A EAE + W L ++ LR + E Q + A E ++ ER RRR + E
Sbjct: 1649 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1708
Query: 252 RA-RERE-AEREAEAARAVER---------EQEIDRWRVKCVQEVEEKKREQELKAAADG 300
+A R+RE AE+E E R + EQE+ R R E ++ EQ+ + +
Sbjct: 1709 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR------AETEQGEQQRQLLEEE 1762
Query: 301 VLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIK 360
+ R+ A T++ ++ L K+R + A K S T QRL
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR-STSEKSKQRLEAEAG 1821
Query: 361 KRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQK 404
+ EL E R + E +++ + E +QR E E++L +K
Sbjct: 1822 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1865
Score = 49.7 bits (117), Expect = 6e-06
Identities = 61/268 (22%), Positives = 111/268 (41%), Gaps = 52/268 (19%)
Query: 196 REAEADGAAWVLLYSQTAPLRAELA---ERLQPLTQAAYVGEARRRLERVRRRRLRLRER 252
R+ E + A + + A +AEL R++ + + + LE R+R+L E
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2007
Query: 253 AREREAEREAEAARAVERE---------QEIDRWRVK--------------------CVQ 283
R REAE + + A E E +E++R + K Q
Sbjct: 2008 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
Query: 284 EVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRAL----EKLRKLRKEA-AARKGV 338
E +K+ + E KA A V + ++ Q ++ +L L E R+ +EA AR
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQA 2127
Query: 339 CPPASADETFTHHLQRLRKLIKKRSEL-YEAEERALRVMLEGEQEEERKRELE------- 390
A+ +RL++ +++++ +A+ A ++ E EQE R+ + E
Sbjct: 2128 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2187
Query: 391 -------KKQRKEKEKILLQKREIESKL 411
+K +K E+ L QK ++E +L
Sbjct: 2188 QAADAEMEKHKKFAEQTLRQKAQVEQEL 2215
Score = 47.0 bits (110), Expect = 4e-05
Identities = 49/216 (22%), Positives = 98/216 (45%), Gaps = 10/216 (4%)
Query: 231 YVGEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKR 290
++ E RR+E RL ++RA ERE E EAA +R+ + K E E K+
Sbjct: 1363 FISETLRRMEE--EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1420
Query: 291 EQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAAR-KGVCPPASADETFT 349
+Q ++ VR+++A E+L++LR+ + A + A A E
Sbjct: 1421 QQRMQEEV------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1474
Query: 350 HHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIES 409
++ ++++ + E E + L+ + + E +K+Q +E+ + L ++ + ES
Sbjct: 1475 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1534
Query: 410 KLFGDPDEFPLAHLLEPFRQYYLQAEHSLPALIQIR 445
+ E LA ++ + + + +L AL ++R
Sbjct: 1535 QRKRQA-EVELASRVKAEAEAAREKQRALQALEELR 1569
Score = 43.1 bits (100), Expect = 6e-04
Identities = 60/250 (24%), Positives = 107/250 (42%), Gaps = 19/250 (7%)
Query: 173 EVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYV 232
E R RL + + R L++A +A+A + L+ + E + +AA
Sbjct: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAER------EAKELQQRMQEEVVRREEAAVD 1437
Query: 233 GEARRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKRE- 291
+ ++R + ++LR A + R+AEAA E + V+ E E++R
Sbjct: 1438 AQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1497
Query: 292 -----QELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADE 346
Q L+A A+ ++ R+ Q + +R+ ++ E RK + E V A A
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR 1556
Query: 347 TFTHHLQRLRKLIKKRSE----LYEAE-ERALRVMLEGE-QEEERKRELEKKQRKEKEKI 400
LQ L +L + E L +AE ERA +V + E + + EL+ K+ EK
Sbjct: 1557 EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1616
Query: 401 LLQKREIESK 410
+R ++ +
Sbjct: 1617 AQLERSLQEE 1626
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/235 (22%), Positives = 103/235 (43%), Gaps = 28/235 (11%)
Query: 177 RLLRALRLVRRLRGLSQALR-EAEADGAAWVLLYSQTAPLRAELAERLQPLTQAAYVGEA 235
R L L +++ + +A R +AEA+ L Q L E A RLQ + +
Sbjct: 2332 RALAEKMLKEKMQAVQEATRLKAEAE------LLQQQKELAQEQARRLQEDKE-----QM 2380
Query: 236 RRRLERVRRRRLRLRERAREREAEREAEAARAVEREQEIDRWRVKCVQEVEEKKREQELK 295
++L + R E R+R+ E AEA R R E+ R + + ++ Q +
Sbjct: 2381 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA------QRFR 2434
Query: 296 AAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAARKGVCPPASADETFTHHLQRL 355
A+ + ++ + + T+ V +++ LE R+ A R + + E LQ+
Sbjct: 2435 KQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER--LREAIAELEREKEKLQQE 2492
Query: 356 RKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRKEKEKILLQKREIESK 410
KL++ +SE + ++ EQ + + L++ EK+ +L ++R IE +
Sbjct: 2493 AKLLQLKSEEMQT--------VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQE 2539
Score = 41.2 bits (95), Expect = 0.002
Identities = 64/256 (25%), Positives = 102/256 (39%), Gaps = 38/256 (14%)
Query: 181 ALRLVRRLRGL---SQALRE-AEADGAAWVLLYSQTAPLRAELAERL------------- 223
AL V RL+ ++ LRE AE + A + L + A R + E+
Sbjct: 2034 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093
Query: 224 QPLTQAAYV-----GEA---RRRLERVRRRRLRL-RERAREREAEREAEAARAVEREQEI 274
Q L Q V GEA RR E R++ RE A+ R EAE + EQ
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2153
Query: 275 DRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRALEKLRKLRKEAAA 334
R + + E K+ EQE A + +R+KQA M EK +K ++
Sbjct: 2154 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM-------EKHKKFAEQTLR 2206
Query: 335 RKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQR 394
+K A ++ T +L + +++ L E +R E ++ + E R
Sbjct: 2207 QK-----AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261
Query: 395 KEKEKILLQKREIESK 410
+ E++ K IE++
Sbjct: 2262 VQMEELSKLKARIEAE 2277
Score = 38.9 bits (89), Expect = 0.011
Identities = 73/298 (24%), Positives = 119/298 (39%), Gaps = 58/298 (19%)
Query: 164 RTHAGPSLGEVRARLLRA--LRLVRRLRGLSQALREAEAD----GAAWVLLYSQTAPLRA 217
R A GE + +LL RL R +Q +E EA+ A +L + A
Sbjct: 1744 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1803
Query: 218 ELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERARERE------AEREAEAARAV- 268
E + Q A G R E R R E R+R+ A + AEA R +
Sbjct: 1804 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1863
Query: 269 ---------------------EREQEIDRWRVKCVQEVEEKKREQEL----KAAADGVLS 303
E+E E +R R E +++R +E KA + L+
Sbjct: 1864 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1923
Query: 304 EVRK-KQADTKRMVDILR-ALEKLRKLRKEAAARKGVCPPASADET-FTHHLQRLRK--- 357
++RK ++ +R ++ L + R++ +E A K A+A + L R+R
Sbjct: 1924 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1983
Query: 358 ---LIKKRSELYEAEERALRVMLEGEQEEERKRELEKKQRK----EKEKILLQKREIE 408
K+++EL A +R L +EE R+RE E++ +K E+E +K +E
Sbjct: 1984 DTLRSKEQAELEAARQRQL-----AAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036
Score = 31.2 bits (69), Expect = 2.2
Identities = 32/145 (22%), Positives = 67/145 (46%), Gaps = 14/145 (9%)
Query: 163 QRTHAGPSLGEVRARLLRALRLVRRLRGLSQALREAEADGAAWVLLYSQTAPLRAELAER 222
Q H L E A L R +++ L Q E LL A ++ L+E+
Sbjct: 2467 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK 2526
Query: 223 LQPLTQAAYVGEARRRLERV------RRRRLRLRERAREREAEREA--------EAARAV 268
L + ++ + + +LE++ + ++LR ++ ++++ E+E EA R
Sbjct: 2527 DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2586
Query: 269 EREQEIDRWRVKCVQEVEEKKREQE 293
+E R + + +Q++E+++R+QE
Sbjct: 2587 HEAEEGVRRKQEELQQLEQQRRQQE 2611
Score = 30.8 bits (68), Expect = 2.9
Identities = 56/244 (22%), Positives = 101/244 (41%), Gaps = 25/244 (10%)
Query: 148 EAVFGTPRRAGCPVPQRTHAGPSLGEV-RARLLRALRLVRRLRGLSQALREAEADGAAWV 206
E V P + R+ +LG++ + R L A+ L +L+ +S +R + GA V
Sbjct: 1075 EKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYL-EKLKTISLVIRGTQ--GAEEV 1131
Query: 207 LLYSQTAPLRAELAERLQPLTQA--AYVGEARRRLERVRRRRLRLRERAREREAEREAEA 264
L + A+ P +A A + + R + E + LR+ R + E
Sbjct: 1132 LRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1191
Query: 265 ARAVEREQEIDRWRVKCVQEVEEKKREQELKAAADGVLSEVRKKQADTKRMVDILRA-LE 323
R ER+ E++RWR + Q +E + L ++ ++ + D L A L+
Sbjct: 1192 QRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQ 1251
Query: 324 KLRKLRKEAAARKGVCPPASADETFTHHLQRLRKLIKKRSELYEAEERALRVMLEGEQEE 383
R+ +++ A P A + Q +R+ +++ L E ER GE+ E
Sbjct: 1252 DARRRQEQIQA----MPLADS--------QAVREQLRQEQALLEEIER------HGEKVE 1293
Query: 384 ERKR 387
E +R
Sbjct: 1294 ECQR 1297
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.137 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,150,369
Number of Sequences: 37866
Number of extensions: 2487493
Number of successful extensions: 93038
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1342
Number of HSP's successfully gapped in prelim test: 2272
Number of HSP's that attempted gapping in prelim test: 22048
Number of HSP's gapped (non-prelim): 28919
length of query: 485
length of database: 18,247,518
effective HSP length: 106
effective length of query: 379
effective length of database: 14,233,722
effective search space: 5394580638
effective search space used: 5394580638
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.