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Search of human proteins with 217416394
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217416394 hyaluronan-mediated motility receptor isoform b
[Homo sapiens]
(724 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 1387 0.0
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 1382 0.0
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 1348 0.0
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 1211 0.0
gi|9910266 kinesin family member 15 [Homo sapiens] 134 3e-31
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 126 8e-29
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 125 1e-28
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 124 4e-28
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 123 5e-28
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 123 7e-28
gi|156104908 myosin heavy chain 6 [Homo sapiens] 122 2e-27
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 121 3e-27
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 119 1e-26
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 118 2e-26
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 117 4e-26
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 117 5e-26
gi|38044112 restin isoform b [Homo sapiens] 117 5e-26
gi|4506751 restin isoform a [Homo sapiens] 117 5e-26
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 116 6e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 116 8e-26
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 116 8e-26
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 115 1e-25
gi|21735548 centrosomal protein 2 [Homo sapiens] 115 2e-25
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 115 2e-25
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 114 2e-25
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 114 2e-25
gi|32698688 citron [Homo sapiens] 113 5e-25
gi|31982906 cingulin-like 1 [Homo sapiens] 113 7e-25
gi|34577114 cytomatrix protein p110 [Homo sapiens] 112 2e-24
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 111 2e-24
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 1387 bits (3590), Expect = 0.0
Identities = 724/724 (100%), Positives = 724/724 (100%)
Query: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
Query: 61 TLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLN 120
TLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLN
Sbjct: 61 TLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLN 120
Query: 121 AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK 180
AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK
Sbjct: 121 AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK 180
Query: 181 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 240
MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI
Sbjct: 181 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 240
Query: 241 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 300
SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK
Sbjct: 241 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 300
Query: 301 EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL 360
EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL
Sbjct: 301 EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL 360
Query: 361 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL 420
CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL
Sbjct: 361 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL 420
Query: 421 KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 480
KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL
Sbjct: 421 KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 480
Query: 481 QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 540
QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL
Sbjct: 481 QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 540
Query: 541 QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 600
QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF
Sbjct: 541 QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 600
Query: 601 EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC 660
EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC
Sbjct: 601 EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC 660
Query: 661 QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ 720
QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ
Sbjct: 661 QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ 720
Query: 721 ESWK 724
ESWK
Sbjct: 721 ESWK 724
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 1382 bits (3578), Expect = 0.0
Identities = 724/725 (99%), Positives = 724/725 (99%), Gaps = 1/725 (0%)
Query: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
Query: 61 TLPASARKVKSSESK-ESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 119
TLPASARKVKSSESK ESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL
Sbjct: 61 TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 120
Query: 120 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 179
NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET
Sbjct: 121 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 180
Query: 180 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 239
KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE
Sbjct: 181 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 240
Query: 240 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 299
ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE
Sbjct: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 300
Query: 300 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 359
KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK
Sbjct: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
Query: 360 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 419
LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK
Sbjct: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
Query: 420 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 479
LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS
Sbjct: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
Query: 480 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 539
LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD
Sbjct: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
Query: 540 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 599
LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA
Sbjct: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
Query: 600 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 659
FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR
Sbjct: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
Query: 660 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 719
CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC
Sbjct: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 720
Query: 720 QESWK 724
QESWK
Sbjct: 721 QESWK 725
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 1348 bits (3490), Expect = 0.0
Identities = 709/724 (97%), Positives = 709/724 (97%), Gaps = 15/724 (2%)
Query: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
Query: 61 TLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLN 120
TLPASARKVKSSESK IRVLLQERGAQDRRIQDLETELEKMEARLN
Sbjct: 61 TLPASARKVKSSESK---------------IRVLLQERGAQDRRIQDLETELEKMEARLN 105
Query: 121 AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK 180
AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK
Sbjct: 106 AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK 165
Query: 181 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 240
MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI
Sbjct: 166 MRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 225
Query: 241 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 300
SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK
Sbjct: 226 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 285
Query: 301 EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL 360
EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL
Sbjct: 286 EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL 345
Query: 361 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL 420
CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL
Sbjct: 346 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL 405
Query: 421 KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 480
KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL
Sbjct: 406 KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 465
Query: 481 QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 540
QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL
Sbjct: 466 QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 525
Query: 541 QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 600
QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF
Sbjct: 526 QNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 585
Query: 601 EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC 660
EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC
Sbjct: 586 EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC 645
Query: 661 QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ 720
QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ
Sbjct: 646 QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQ 705
Query: 721 ESWK 724
ESWK
Sbjct: 706 ESWK 709
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 1211 bits (3132), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 91 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 150
IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL
Sbjct: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64
Query: 151 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 210
KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA
Sbjct: 65 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124
Query: 211 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 270
QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS
Sbjct: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
Query: 271 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 330
LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ
Sbjct: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 244
Query: 331 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 390
EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ
Sbjct: 245 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 304
Query: 391 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 450
KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ
Sbjct: 305 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 364
Query: 451 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 510
SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR
Sbjct: 365 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 424
Query: 511 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 570
MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA
Sbjct: 425 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 484
Query: 571 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 630
ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG
Sbjct: 485 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 544
Query: 631 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 690
HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA
Sbjct: 545 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 604
Query: 691 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 724
FHHESKENFALKTPLKEGNTNCYRAPMECQESWK
Sbjct: 605 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 638
Score = 48.1 bits (113), Expect = 3e-05
Identities = 74/356 (20%), Positives = 155/356 (43%), Gaps = 45/356 (12%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQER 98
QK F+++ ++NL ++ L + ++ + KE Q ++ +K LE+E + +E
Sbjct: 272 QKLCSFQEEMVKEKNLFEEE---LKQTLDELDKLQQKEEQA-ERLVKQLEEEAKSRAEEL 327
Query: 99 GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG 158
+ +++ E ELEK +AA + T L L+++ + ++ E + ++F
Sbjct: 328 KLLEEKLKGKEAELEKS----SAAHTQATLL------LQEKYDSMVQSLEDVTAQFE--- 374
Query: 159 NQKNLRILSLELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRSLEESQGKIAQLEGKLV 217
+ K L +E +KL N + K E ++ ++ T+ S +E + L+
Sbjct: 375 SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQ---- 430
Query: 218 SIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-----------AQLEENLKEKND 266
K + E E + ++++I+ +Q+++ + D A+ E E +
Sbjct: 431 --TKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTE 488
Query: 267 EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI 326
EI + EE L + + ++ E EK+ +N + E LN ++++ K +
Sbjct: 489 EINKWRLLYEE----LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN-KIRDSYAKLL 543
Query: 327 LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 382
Q L+QK + L + +L S + + C ++ E L +EEL + L
Sbjct: 544 GHQ----NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKL-QEELNKVL 594
>gi|9910266 kinesin family member 15 [Homo sapiens]
Length = 1388
Score = 134 bits (337), Expect = 3e-31
Identities = 157/680 (23%), Positives = 306/680 (45%), Gaps = 81/680 (11%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSE----SKESQKNDKDLKILEKEIRVLLQERGA 100
++ K K +VDK +++ SSE +K+ ++ L +LEK+++ +
Sbjct: 736 EEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDF 795
Query: 101 QDRRIQDLETELEKMEARLNAALREKTS-----------LSANNATLEKQLIELTRTNE- 148
+ DL L + L++ E +S LS + ++ QL L NE
Sbjct: 796 LKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEK 855
Query: 149 LLKSKFSENGNQKNLRILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 207
LL+SK + NL+ E+MK ++ ++ + E ++ L LE +
Sbjct: 856 LLESKACLQDSYDNLQ----EIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKE 911
Query: 208 KIAQLEGKLVSIEKEKIDEKSETEKLLEYI-EEISCASDQVEKYKLDIAQLEENLKEKND 266
+ +L + E++K + E K+LE + +E + + E+ + +LEE+L
Sbjct: 912 RNNKLS---LQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEK 968
Query: 267 EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF- 325
I SL++S + + K V DL + Q E V E + L E++++ K+
Sbjct: 969 VISSLEKSRDSD----KKVVADLMNQIQ----ELRTSVCEKTETIDTLKQELKDINCKYN 1020
Query: 326 -ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDE 384
L +E ++ K+ ++D L +L +L ++ S E++ E+++ E+L ++
Sbjct: 1021 SALVDREESRVLIKKQEVDIL-----DLKETLRLRILS--EDI--ERDMLCEDLAHATEQ 1071
Query: 385 LDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEK 444
L+ L + ++ L++ +EE + ++ L+ KL K+ E+E+ + L+
Sbjct: 1072 LNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHV 1131
Query: 445 YDSMVQSLED--VTAQFESYKA----LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 498
DS + + F+++ A EIED + +SL+ K ++ E +I
Sbjct: 1132 MDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEI 1191
Query: 499 LATESSNQEYVRMLLDLQT---KSALKETEIKEITVSFLQKITDLQN-----QLKQQEED 550
L + +E + L+ Q K+ L + ++ +I QK QN QLK ++E+
Sbjct: 1192 LRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIK---RQKENSDQNHPDNQQLKNEQEE 1248
Query: 551 FRKQ-----------------LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPF 593
K+ LE+ + KE +T+E+ + + L + + + +
Sbjct: 1249 SIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQL 1308
Query: 594 QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKS 653
+ +L+ E++ E ++Q+ + + KL+GHQNL QKI++VV+LK EN +L
Sbjct: 1309 RSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAE 1368
Query: 654 EVSKLRCQ---LAKKKQSET 670
E KLR + L +KK+SE+
Sbjct: 1369 ETEKLRAENVFLKEKKRSES 1388
Score = 77.0 bits (188), Expect = 6e-14
Identities = 158/749 (21%), Positives = 318/749 (42%), Gaps = 126/749 (16%)
Query: 38 FQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEI----RV 93
FQ++ F ++ E ++ ++K T L K + K Q N +K E +I ++
Sbjct: 418 FQEAMLFFKKSEQEKKSLIEKVTQLEDLTLK----KEKFIQSNKMIVKFREDQIIRLEKL 473
Query: 94 LLQERGA-----QDRRIQDLETELEKMEARL------------NAALREKT--------- 127
+ RG QDR + +L E++ + ++ N +LRE+
Sbjct: 474 HKESRGGFLPEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPV 533
Query: 128 ----SLSANN-ATLEKQLIELTRTNELLKSK--FSENGNQKNLRILSLELMKLRNKR-ET 179
+ A A LEK E++ + K++ FS ++ + E +K + + +T
Sbjct: 534 KRAQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQT 593
Query: 180 KMRGMMAKQEGMEMKLQVTQRSLE-ESQGKIAQ-----LEGKLVSIEKEKIDEKSETEKL 233
++ +KQE E K +R LE ES+ + Q LE L + + K E S+ K+
Sbjct: 594 ELNN--SKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKI 651
Query: 234 LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKC 293
+ E + + + Y+L + + + E+ S +N IL + + V
Sbjct: 652 --HAETLKIITTPTKAYQLH----SRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPP 705
Query: 294 QLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELS 353
++ E+ E R E ++A L+ K E+ + KLQQ +++ Q +EL
Sbjct: 706 EMNEQAFEAISEELRTVQEQMSA----LQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELF 761
Query: 354 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 413
SS QEE++ + N+ E++L++T + D L+ + ++ ++E S +
Sbjct: 762 SSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSS----V 817
Query: 414 KLLEEKLK-GKEAELEKSSAAHTQATL-----------------LLQEKYDSMVQSLEDV 455
KL K +E E K S H L LQ+ YD++ + ++
Sbjct: 818 KLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFE 877
Query: 456 TAQFESYKALTASEIEDLKLENSSLQE--KAAKAGKNAEDVQHQILATESSNQEYVRML- 512
Q E E LK + ++L E +A K N +Q + E+S++E +++L
Sbjct: 878 IDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFE-EDKENSSKEILKVLE 936
Query: 513 ---LDLQTKSALKETEIKEI------------TVSFLQK--------ITDLQNQLKQQEE 549
+ Q ++A E ++ ++ +S L+K + DL NQ+++
Sbjct: 937 AVRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRT 996
Query: 550 DFRKQLEDEEGRKAEKENTTAELTEEI---NKWRLLYE----ELYNKTKPFQLQLDAFEV 602
++ E + K E ++ + + + R+L + ++ + + +L++ + ++
Sbjct: 997 SVCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDI 1056
Query: 603 EKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQL 662
E+ L + A EQLN + ++ K H L Q ++E ++ ++ + +L+ +L
Sbjct: 1057 ERDMLCEDLAHATEQLNMLTEASKK---HSGLLQ------SAQEELTKKEALIQELQHKL 1107
Query: 663 AKKKQSETKLQEELN-KVLGIKHFDPSKA 690
+KK+ + + E N K+ ++H S A
Sbjct: 1108 NQKKEEVEQKKNEYNFKMRQLEHVMDSAA 1136
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 126 bits (316), Expect = 8e-29
Identities = 153/676 (22%), Positives = 306/676 (45%), Gaps = 69/676 (10%)
Query: 69 VKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELE-------KMEARLNA 121
+K S+ KE Q++ L+ LE + + +L E + +++DL+ E E ++E+ L
Sbjct: 523 LKISQEKEQQES-LALEELELQKKAILTE---SENKLRDLQQEAETYRTRILELESSLEK 578
Query: 122 ALREKTSLSAN-----NATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK 176
+L+E + S + A K E+T E K++ +Q++ + + +L L+ +
Sbjct: 579 SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDA-LWTEKLQVLKQQ 637
Query: 177 RETKMRGMMAKQEG-----MEMKLQVTQRSLEESQGK-IAQLEGKLVSIEK--EKIDEKS 228
+T+M + K E ++ K + Q +EE K + +L+ K +E ++ E
Sbjct: 638 YQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVL 697
Query: 229 ETEKLLEYIEEISCASDQVEKYKLDI-AQLEENLKEKNDEILSLKQSLEENIVILSKQVE 287
+ LE EE+S DQ +K K ++ A+++E ++ S+ + E +I K ++
Sbjct: 698 KARHKLE--EELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK 755
Query: 288 DLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQ 347
D + +LL KE++ H+ ++ H ENL A+++ + + + + Q + +
Sbjct: 756 DQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTK 815
Query: 348 QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAK 407
+E + L QKL + E + E Q D +L + Q + L++QLE++
Sbjct: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNS 875
Query: 408 SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLE-----------DVT 456
+++K L + E++LE + Q +L EK + ++Q E ++
Sbjct: 876 EMEQKVKSLTQVY---ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLS 932
Query: 457 AQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESS-NQEYVRMLLDL 515
A+ +S L K + +++ KA + E ++ ++L E+ +E L+L
Sbjct: 933 AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALEL 992
Query: 516 QTKSALKETEIKEITVSFLQKITDLQNQLKQQEED--------FRKQLEDEEGRKAEKEN 567
K ++ E+ + I+D ++L+ +++ R++L D +K N
Sbjct: 993 SQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLN 1052
Query: 568 TTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL------LNEHGAAQE-QLNK 620
AE +EI++ +L +E + + ++ F EK+ + L E G Q+ LN+
Sbjct: 1053 QQAEELQEIHEIQL--QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNE 1110
Query: 621 IRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 680
++ + LKQK HV L + ++LK+ + KL L K + T LQE+L ++
Sbjct: 1111 LQ---------EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK 1161
Query: 681 GIKHFDPSKAFHHESK 696
+ D K SK
Sbjct: 1162 MLAEEDKRKVSELTSK 1177
Score = 112 bits (281), Expect = 9e-25
Identities = 138/705 (19%), Positives = 307/705 (43%), Gaps = 75/705 (10%)
Query: 29 LEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILE 88
L+VLK + + ++ ++ K+ L DK+ A ++ ++ +L+ L
Sbjct: 631 LQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLS 690
Query: 89 KEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSAN--NATLEKQLIELTRT 146
E+ +L+ R + + L+ + +KM+ L A + E+ + ++ +++ + + RT
Sbjct: 691 SELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRT 750
Query: 147 NELLKSKFSE-----NGNQKNLRILSLELMKLR---NKRETKMRGMMAKQEGMEMKLQVT 198
+ LK + ++ K+L+ + L + E +++ AK + + T
Sbjct: 751 EKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSAT 810
Query: 199 QRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE 258
+ + ++AQL+ KL+ +E E+I T+++ E + +++ +K+ + L
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERI---LLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867
Query: 259 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEM 318
+ L+++N E ++Q ++ + ++ED N + + ++ + N + E E+
Sbjct: 868 QQLEKQNSE---MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI 924
Query: 319 QNLKQKF--------ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 370
+ L QK IL ++ K + +E +++ + Q+ KE+ +L +KL + ++ KE
Sbjct: 925 EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984
Query: 371 -----KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL-KLLEEKLKGKE 424
L ++E + L+ Q V +LE K + E L ++ +L
Sbjct: 985 LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVI 1044
Query: 425 AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 484
+ EK Q LQE ++ +Q E A+ + L E E++ E + L+E+
Sbjct: 1045 SIWEKKL---NQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
Query: 485 AKAGKNAEDVQHQI---------LATESSNQEYVRMLLDLQTKSALKE--------TEIK 527
K ++Q Q+ LA + + + L++ +LKE E+K
Sbjct: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELK 1161
Query: 528 EITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELY 587
+ +K+++L ++LK +E+F + K+ E + L ++ +++ L EEL
Sbjct: 1162 MLAEEDKRKVSELTSKLKTTDEEF-------QSLKSSHEKSNKSLEDKSLEFKKLSEEL- 1213
Query: 588 NKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN----KIRDSYAKLLGHQNLKQKIKHVVK 643
+QLD + +ALL E +N K +++ Q+ K+K +
Sbjct: 1214 ------AIQLDICCKKTEALL--EAKTNELINISSSKTNAILSRISHCQHRTTKVKEALL 1265
Query: 644 LK-----DENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 683
+K + +QL+ + +Q+ +L+E+ N++ +K
Sbjct: 1266 IKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMK 1310
Score = 110 bits (274), Expect = 6e-24
Identities = 158/687 (22%), Positives = 300/687 (43%), Gaps = 109/687 (15%)
Query: 87 LEKEIRVLLQERGAQD-------RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQ 139
LE ++R L +E+ + ++++ E +++ M+A + + + EK +L ++
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQA 1333
Query: 140 LIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQ 199
E LK + SEN N ++ LMK K + K E + Q+T
Sbjct: 1334 ASEKESCITQLKKELSENIN-------AVTLMKEELKEK--------KVEISSLSKQLTD 1378
Query: 200 RSLE-ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE 258
+++ ++ +++ E + S+ K+ +EK E LL+ ++++S D + K K+ +
Sbjct: 1379 LNVQLQNSISLSEKEAAISSLRKQYDEEKCE---LLDQVQDLSFKVDTLSKEKISALEQV 1435
Query: 259 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE---KEDHVNRNREHNENLN 315
++ K E K+ + V++L ++ +L KE K++ +N +E + N
Sbjct: 1436 DDWSNKFSE---WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQN 1492
Query: 316 AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK----ELSSSLHQKLCSFQE--EMVK 369
LK + + ++ K+++KE +++ L+ + EL + QK + E++K
Sbjct: 1493 KRFDCLKGEM---EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
Query: 370 ----EKNLFEEELKQTLDELDKLQQKEE----QAERLVKQLEEEAKSRAEEL-------- 413
+K++ +EL Q L +L ++++ +AE + LE + S EL
Sbjct: 1550 NYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE 1609
Query: 414 ------KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMV--QSLEDVTAQFESYKAL 465
K EE+LK E LE SAA E+ + + Q L + + E YK
Sbjct: 1610 HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG 1669
Query: 466 TASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETE 525
T S + +L N+ LQE+ + ++ ++ + ESS E +++ K+ TE
Sbjct: 1670 TESHLSEL---NTKLQERE----REVHILEEKLKSVESSQSE--TLIVPRSAKNVAAYTE 1720
Query: 526 IKE------ITVSFLQKITDLQNQLKQQEEDFRKQLEDEE--------------GRKAEK 565
+E + ++ +KI+ LQ L ++E+ ++ +++E R +
Sbjct: 1721 QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKL 1780
Query: 566 ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 625
E+ A+ E+ + L EEL K K + L + A VEK+ N A Q N D
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSL-IVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 626 AKL----LGHQNLKQKIKH----VVKLKD----ENSQLKSEVSKLRC-QLAKKKQSETKL 672
L L Q L+QKIK +V+ K+ E +L S+ KL+ Q + T+L
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL 1899
Query: 673 QEELNKVLGIKHF-DPSKAFHHESKEN 698
EE + H P + E++ N
Sbjct: 1900 LEENTEEKSKSHLVQPKLLSNMEAQHN 1926
Score = 105 bits (263), Expect = 1e-22
Identities = 161/721 (22%), Positives = 298/721 (41%), Gaps = 101/721 (14%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQ 106
Q+ KQN +++ + K + + Q+ K + ++EKE ++LQ R Q + I+
Sbjct: 868 QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQI-LVEKE-NMILQMREGQKKEIE 925
Query: 107 DLETELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNELLKSKF--SENGNQKNL 163
L +L E ++ E +T +EK + E LK K E +K L
Sbjct: 926 ILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKEL 985
Query: 164 RILSLELMKLRNKRETKMRGM-MAKQEGME---MKLQVTQRSLEESQGKIAQLE-GKLVS 218
+LEL + + KM M A G+ +L+ Q+ ES ++ + E ++S
Sbjct: 986 ENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVIS 1045
Query: 219 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL-------KEKNDEILSL 271
I ++K+++++E L+ I EI Q+++ + ++A+L++ + +E N EI L
Sbjct: 1046 IWEKKLNQQAEE---LQEIHEI-----QLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
Query: 272 KQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE 331
K+ + L++ E L K+K HVN + L A ++ L+ +E
Sbjct: 1098 KEEGVKQDTTLNELQEQL--------KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKE 1149
Query: 332 REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDE-LDKLQQ 390
LQ++ +++ L +++K S L KL + EE K+ E+ K D+ L+ +
Sbjct: 1150 NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
Query: 391 KEEQAERL---VKQLEEEAKSRAEELKLLEEK----------------LKGKEA------ 425
EE A +L K+ E +++ EL + K KEA
Sbjct: 1210 SEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTC 1269
Query: 426 ---ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 482
ELE T+ L + LE+ Q +S KA +IE L E +LQ+
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA----DIESLVTEKEALQK 1325
Query: 483 KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN 542
+ + A + + I + E + + ++ + K+ EI ++ LQN
Sbjct: 1326 EGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQN 1385
Query: 543 QLKQQEED-----FRKQLEDEEGRKAE-------------KENTTAELTEEINKWRLLYE 584
+ E++ RKQ ++E+ + KE +A E+++ W +
Sbjct: 1386 SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISA--LEQVDDWSNKFS 1443
Query: 585 EL-----------YNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 633
E N K Q+QL+ E + +E+L++ + L G
Sbjct: 1444 EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
Query: 634 LKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHH 693
K K K + ++LKS+ +++ +L +T E LN+VL K+++ K H
Sbjct: 1504 -DDKSKMEKKESNLETELKSQTARI-MELEDHITQKTIEIESLNEVL--KNYNQQKDIEH 1559
Query: 694 E 694
+
Sbjct: 1560 K 1560
Score = 92.0 bits (227), Expect = 2e-18
Identities = 159/706 (22%), Positives = 309/706 (43%), Gaps = 122/706 (17%)
Query: 26 VKTLEV---LKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDK 82
VK L++ LK +++K ++ KE N D +K + K +K
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC--------LKGEMEDDKSKMEK 1511
Query: 83 DLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIE 142
LE E++ +Q RI +LE + + + + + + K+L++
Sbjct: 1512 KESNLETELK-------SQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ 1564
Query: 143 LTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL 202
+ F E G +K+ R+ E L E ++ M A+ E + +L+ S+
Sbjct: 1565 KLQ-------HFQELGEEKDNRVKEAEEKIL--TLENQVYSMKAELETKKKELEHVNLSV 1615
Query: 203 EESQGKIAQLEGKLVSIEKEKIDE-KSETEKLLEYIEE--ISCASDQVEKYK----LDIA 255
+ + ++ LE +L S K+ E K + E+ + I++ +S ++ E+YK ++
Sbjct: 1616 KSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS 1675
Query: 256 QLEENLKEKNDEILSLKQSLEENIVILSKQVEDL-------NVKCQLLEKEKEDHVNRNR 308
+L L+E+ E+ L++ L+ + S Q E L NV ++E + +
Sbjct: 1676 ELNTKLQEREREVHILEEKLKS---VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQK 1732
Query: 309 EHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL-CSFQEEM 367
+ E ++ +NL E+EKL Q+ + QEKE + S H ++ C +QE +
Sbjct: 1733 TYEEKISVLQRNL--------TEKEKLLQR-------VGQEKEETVSSHFEMRCQYQERL 1777
Query: 368 VKEKNLFEEELKQTLDE------LDKLQQKEEQAERLVKQLEE--------EAKSRAEEL 413
+K L E KQ D+ ++L++K ++ +V Q E +AK E +
Sbjct: 1778 IK---LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENV 1834
Query: 414 -----KLLEEK------LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY 462
K L+EK L+ K EL+ + L+++K V+ +E++T+++E
Sbjct: 1835 FDDVQKTLQEKELTCQILEQKIKELD---------SCLVRQKEVHRVE-MEELTSKYEKL 1884
Query: 463 KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 522
+AL +++ L+E + K+ H + SN E L+ + A +
Sbjct: 1885 QAL--QQMDGRNKPTELLEENTEEKSKS-----HLVQPKLLSNMEAQHNDLEFKLAGAER 1937
Query: 523 ETEIKEITVSFLQK-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL 581
E + + LQK + L+ + +Q+ E +K+ + E K ++E EL +L
Sbjct: 1938 EKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQL 1997
Query: 582 LYE---ELYNKTKPFQLQL-----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 633
+ E +L K + ++ + A EVE + LL H QE+ N++ A+ +
Sbjct: 1998 MREFNTQLAQKEQELEMTIKETINKAQEVEAE-LLESH---QEETNQLLKKIAE--KDDD 2051
Query: 634 LKQKIKHVVKLKD-ENSQLKSEVSKLRCQLAK-KKQSETKLQEELN 677
LK+ K ++ D ++ ++V L+ QL + +K+ + KL++E N
Sbjct: 2052 LKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097
Score = 89.4 bits (220), Expect = 1e-17
Identities = 135/637 (21%), Positives = 281/637 (44%), Gaps = 100/637 (15%)
Query: 125 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNL----RILSLELMKLRN----K 176
E L N+ +L K+ + + R + +S S G L ++L E KL+
Sbjct: 123 EAEDLVGNSDSLNKEQL-IQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQS 181
Query: 177 RETKMRGMMAKQEGMEMKLQVTQR-------SLEESQGKIAQLEGKLVSIEKEKIDEKSE 229
++ +R + +E ++M Q + SLEE I+ L+ + VS+ K+++
Sbjct: 182 QDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQ-VSLLKQRLRNGPM 240
Query: 230 TEKLLEYIEEISCASDQVEKYKLDIAQ----LEENLKEKNDEILSLKQSLEENIVILSKQ 285
+L+ + ++ ++ K + + +E+ K E L + +EN++ K+
Sbjct: 241 NVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKE 300
Query: 286 -VEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 344
++ +C LL EKE E L+ +Q L++ L E+ KL + +
Sbjct: 301 TIQSHKEQCTLLTSEKE-------ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKN 353
Query: 345 LLQQEK--------ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAE 396
L++Q + E +H+ L +EE+ + ++ +KQ + ++L++++E++E
Sbjct: 354 LIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS----RIKQMTTQGEELREQKEKSE 409
Query: 397 RLVKQLEEEAKSRAEELKLLEEKLKGKEAE----LEKSSAAHTQATLLLQEKYDSMVQSL 452
R + E+A S A++ + KLK + E +EK+S + + LQ++ + Q +
Sbjct: 410 RAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE---EERISLQQELSRVKQEV 466
Query: 453 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI-LATESSNQEYVRM 511
DV + + ++ + +L QE K + Q Q+ +A E S EY+++
Sbjct: 467 VDVMKKSSEEQIAKLQKLHEKELARKE-QELTKKLQTREREFQEQMKVALEKSQSEYLKI 525
Query: 512 L-------------LDLQTKSALKETE-----IKEITVSFLQKITDLQNQLKQQEEDFRK 553
L+LQ K+ L E+E +++ ++ +I +L++ L++ ++ +
Sbjct: 526 SQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKN 585
Query: 554 QLED-EEGRKAEKENTTAELTEEINKWRLLYEELYNK-----TKPFQLQLDAFEVEKQAL 607
Q +D +AEK E+T + K + E L ++ T+ Q+ ++ E + L
Sbjct: 586 QSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL 645
Query: 608 LNEHGAAQEQLNK---------IRDSYAKLLGHQNLKQ--------------KIKHVVKL 644
+ +E L K I + K L ++KQ K +H KL
Sbjct: 646 REKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARH--KL 703
Query: 645 KDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNKVL 680
++E S LK + K++ +L AK + + Q++++ ++
Sbjct: 704 EEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740
Score = 77.4 bits (189), Expect = 4e-14
Identities = 126/590 (21%), Positives = 247/590 (41%), Gaps = 107/590 (18%)
Query: 39 QKSQRFKQQKESK-QNLNV---DKDTTLPASARKVKSSESKESQ-----KNDKDLKILEK 89
+K +++K+ ES LN +++ + K+KS ES +S+ ++ K++ +
Sbjct: 1661 EKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTE 1720
Query: 90 EIRVLLQE--RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 147
+ Q + + +I L+ L + E L +EK +++ + Q E R
Sbjct: 1721 QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQE--RLI 1778
Query: 148 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV---------- 197
+L ++ ++ +Q + L EL + +NK+ + + ++EG + +Q
Sbjct: 1779 KLEHAEAKQHEDQSMIGHLQEELEE-KNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDD 1837
Query: 198 TQRSLEESQGKIAQLEGKLVSIE----KEKIDEKSETEKLLEYIEEISCASDQVEKYKLD 253
Q++L+E + LE K+ ++ ++K + E E+L E++ A Q++
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQ-ALQQMDGRNKP 1896
Query: 254 IAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE-----------D 302
LEEN +EK+ L + L + Q DL K E+EK+ D
Sbjct: 1897 TELLEENTEEKSKSHLVQPKLLSN----MEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952
Query: 303 HVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQID--------------SLLQQ 348
+EH + E++ LK+++ E++E+ K +Q++L++ L Q+
Sbjct: 1953 LRMLRKEHQQ----ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQK 2008
Query: 349 EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKS 408
E+EL ++ + + QE E L E ++T L K+ +K++ +R K+ EE +
Sbjct: 2009 EQELEMTIKETINKAQEV---EAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDA 2065
Query: 409 RAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED------VTAQFESY 462
R EE + K++ + +LE+ LQ+KY ++ E+ + ++
Sbjct: 2066 REEE---MTAKVRDLQTQLEE-----------LQKKYQQKLEQEENPGNDNVTIMELQTQ 2111
Query: 463 KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT--------------------E 502
A + I D KL+ +E+ + + + AT E
Sbjct: 2112 LAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGE 2171
Query: 503 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFR 552
+ EY+R +L +T K IT + K D Q Q + ED R
Sbjct: 2172 PTEFEYLRKVLFEYMMGRETKTMAKVITT--VLKFPDDQTQKILEREDAR 2219
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 125 bits (314), Expect = 1e-28
Identities = 146/682 (21%), Positives = 305/682 (44%), Gaps = 91/682 (13%)
Query: 73 ESKESQK--NDKDLKILEKEIRV----LLQERGA----QDRRIQDLETELEKMEARLNAA 122
E E++K +KD +I + R+ LL E+ A + + +++L + E + RL+
Sbjct: 236 ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHET 295
Query: 123 LREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR 182
L++ L + +++++ +L+ N L K E + +L+ L L +L + +
Sbjct: 296 LKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS--HLQQLQDALNELTEEHSKATQ 353
Query: 183 GMMAKQEGMEMKLQVT---QRSLEES----QGKIAQLEGKLVSIEKEKIDEKSETE---- 231
+ KQ +E +L ++ LEE QGK++QLE L ++ EK E
Sbjct: 354 EWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVL 413
Query: 232 KLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNV 291
+L +E + + + + + LE ++ ++L+ + EE LS + DL
Sbjct: 414 QLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQS 473
Query: 292 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI---------------LEQQEREK-- 334
L + KE+ ++ H L A++ +L + L+QQ +EK
Sbjct: 474 SISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA 533
Query: 335 -----LQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQ 389
LQQ+E L Q ++LSSSL QK +E K++ ++ +Q ++ +
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 390 QKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQA---TLLLQEKYD 446
+ + +KQLE K +A +L++L+++L+ + + + TQA L K +
Sbjct: 594 ASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVE 653
Query: 447 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED---VQHQILA--- 500
+ +E TA+ E ++A +++ +L+L+ S Q+KA + + A++ +Q Q+ A
Sbjct: 654 ELQACVE--TARQEQHEA--QAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKE 709
Query: 501 ----TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE-------- 548
T+ S +E R D + +E+K T S +++ + +L+++
Sbjct: 710 SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEA 769
Query: 549 -------------EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQL 595
E R++L + + E+ +L +E+ WR YE+ + +
Sbjct: 770 RLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGA 829
Query: 596 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV 655
F+ + L E A+++L + ++ A + H L+ + + ++E ++L + +
Sbjct: 830 M---FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ-----ISRQQNELAELHANL 881
Query: 656 SKLRCQLAKKKQSETKLQEELN 677
++ Q+ +K+ KL ++L+
Sbjct: 882 ARALQQVQEKEVRAQKLADDLS 903
Score = 99.8 bits (247), Expect = 8e-21
Identities = 154/679 (22%), Positives = 281/679 (41%), Gaps = 95/679 (13%)
Query: 96 QERGAQDRRIQDLETELEKMEA--RLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 153
+ERG Q+R + L E + +A L A R + + NA L +Q +E E L
Sbjct: 997 EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNA-LNEQRVEFATLQEALAHA 1055
Query: 154 FSENGNQKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEMKLQVTQRSLEESQGKIAQL 212
+E + EL KLR +++ + +Q ++K Q+ ++ E + G AQ
Sbjct: 1056 LTEKEGKDQ------ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109
Query: 213 EG---------KLVSIEKEKIDEKSETEKLLEYIEEI--SCASDQVEKYKLDIA--QLEE 259
E KL ++ E + + +K E + + S +++ + + D A L+
Sbjct: 1110 EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQG 1169
Query: 260 NLKEKNDEI---LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA 316
L+EK E+ S S + + +V+D + E E + V R R+ E N+
Sbjct: 1170 QLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA----EDEWKAQVARGRQEAERKNS 1225
Query: 317 EMQNLKQKF-ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE 375
+ +L+++ IL +Q EK + + ++ L+ E E S L ++L Q E
Sbjct: 1226 LISSLEEEVSILNRQVLEK-EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284
Query: 376 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------ELKLLEEKLKGKEAELE 428
E +E+ L+++ E+ + L +E S+AE ELK +EK KE L
Sbjct: 1285 ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS 1344
Query: 429 KSSAAHTQATLLLQEKYDS--MVQSLEDVTAQFE---------SYKALTASEIEDLKLEN 477
HT L+ E + + Q L+ A E S +A E L+ +
Sbjct: 1345 TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQR 1404
Query: 478 S-----SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSA------------ 520
L++K A+ + A+ Q+ A ++S E + ML A
Sbjct: 1405 ELGELIPLRQKVAEQERTAQ----QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL 1460
Query: 521 ---LKETEIKEITVSFLQKI----TDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT 573
E E+ + ++Q++ D + +L + + + + + E A+ E ++
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL 1520
Query: 574 EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS-YAKLLGHQ 632
EE R ++E K QL+ F+ E+ +E K+ DS A + Q
Sbjct: 1521 EE----RQRFQEERQKLTAQVEQLEVFQREQTK------QVEELSKKLADSDQASKVQQQ 1570
Query: 633 NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS--ETKLQEELNKVLGIKHFDPSKA 690
LK + + E +L++++++L+ QL++K+Q+ KLQ E K H+D K
Sbjct: 1571 KLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT----HYDAKKQ 1626
Query: 691 FHHESKENFALKTPLKEGN 709
+ E +E L++ N
Sbjct: 1627 QNQELQEQLRSLEQLQKEN 1645
Score = 94.4 bits (233), Expect = 3e-19
Identities = 126/658 (19%), Positives = 271/658 (41%), Gaps = 63/658 (9%)
Query: 23 AYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT---TLPA-----SARKVKSSES 74
A +K LE L+ V K Q K++KE + T P + R S
Sbjct: 1074 AAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE 1133
Query: 75 KESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNA 134
++ QK + LE+ + R +D ++ L+ +LE+ L + S A
Sbjct: 1134 QQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193
Query: 135 TLEKQLIELTRTNELLKSKFS---ENGNQKNLRILSLE----------LMKLRNKRETKM 181
++ + ++ + K++ + + +KN I SLE L K +E K
Sbjct: 1194 AFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK- 1252
Query: 182 RGMMA---KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLL--EY 236
R +MA K + +E +L++ Q + + A+ L E + + E++E +++
Sbjct: 1253 RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALRE-EVQSLREEAEKQRVASENL 1311
Query: 237 IEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLL 296
+E++ +++ E+ ++ +E +K + +L+ ++S+ + ++ CQ L
Sbjct: 1312 RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHL-CQQL 1370
Query: 297 EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE-------REKLQQKELQIDSLLQQE 349
+ E+ R+RE E L+ + + Q+E R+K+ ++E L ++
Sbjct: 1371 QAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEK 1430
Query: 350 KELSSSL------HQKLCSFQEEMVKEKNLFEEELKQTLDE-----LDKLQQKEEQAERL 398
+ L H L + + NL + L+ LD+ + +L AE
Sbjct: 1431 ASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETR 1490
Query: 399 VKQLEEEAKSRAEELKLLEEKLKGKEA----------ELEKSSAAHTQATLLLQEKYDSM 448
+ +++ EA+S A EL+++ K +G + E + A + + Q +
Sbjct: 1491 LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQ 1550
Query: 449 VQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEY 508
V+ L A + + +++ ++ + Q++A + ++Q Q+ E + + Y
Sbjct: 1551 VEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY 1610
Query: 509 VRMLLDLQTKSALKETEIKEI--TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 566
+ +T K+ + +E+ + L+++ +L+ + E +L+ + E E
Sbjct: 1611 KLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAE 1670
Query: 567 NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS 624
T LT ++ R L ++ + + + L F+V AL + A+ QL+ DS
Sbjct: 1671 QTCRHLTAQV---RSLEAQVAHADQQLR-DLGKFQVATDALKSREPQAKPQLDLSIDS 1724
Score = 32.7 bits (73), Expect = 1.2
Identities = 36/149 (24%), Positives = 65/149 (43%), Gaps = 9/149 (6%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDL 84
+ + L+ + Q SQ K+Q L ++K T K +++E Q+ + L
Sbjct: 1585 EAQRLQAQLNELQAQLSQ--KEQAAEHYKLQMEKAKT----HYDAKKQQNQELQEQLRSL 1638
Query: 85 KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELT 144
+ L+KE + L E +Q + ++ E + SL A A ++QL +L
Sbjct: 1639 EQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLG 1698
Query: 145 R---TNELLKSKFSENGNQKNLRILSLEL 170
+ + LKS+ + Q +L I SL+L
Sbjct: 1699 KFQVATDALKSREPQAKPQLDLSIDSLDL 1727
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 124 bits (310), Expect = 4e-28
Identities = 180/745 (24%), Positives = 320/745 (42%), Gaps = 126/745 (16%)
Query: 39 QKSQRFKQQKESK------QNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIR 92
+K+ R K +K+ + + L + + TL +A + + +K Q+ + K LE+E +
Sbjct: 1130 EKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQ-QELRTKREQEVAELKKALEEETK 1188
Query: 93 VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 152
E QD R Q T LE++ +L A R K +L N LE EL ++L+
Sbjct: 1189 N--HEAQIQDMR-QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQ 1245
Query: 153 KFSENGNQKN------------------LRI-LSLELMKLRNK--------RETKMRGMM 185
+E+ +++ LR+ L+ + KL+N+ E + +G+
Sbjct: 1246 VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK 1305
Query: 186 AKQEG--MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCA 243
++ +E +LQ TQ L+E + L ++ +E+EK L E EE A
Sbjct: 1306 FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK-------NSLQEQQEEEEEA 1358
Query: 244 SDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDH 303
+EK L + + K+K D+ L +SLEE L K E L+ + + EK
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE----EKALA 1414
Query: 304 VNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK---- 359
++ + L E+ +L ++Q L++K+ + D LL +EK +S+ ++
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA 1474
Query: 360 -------------LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 406
L EE ++ K FE + KQ +++ L ++ + V +LE+
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534
Query: 407 KSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT 466
++ ++++ + +L+ E EL+ + A + + +Q + L+ Q E K L
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 467 ASEIEDL--KLENSSLQEKAAKAGK-----NAEDVQHQILATESSNQEYVRMLLDLQTKS 519
++ +L +LE+ Q A A K + +D++ QI A + E ++ L LQ +
Sbjct: 1595 IKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQM 1654
Query: 520 ALKETEIKEITVS----FLQ-------------KITDLQNQLKQQE------EDFRKQLE 556
+ E++E S F Q +I LQ +L E E R +L
Sbjct: 1655 KDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 557 DE-----EGRKA---EK---ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ 605
DE G+ A EK E A+L EE+ + + E L ++ + LQ+D E
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE-- 1772
Query: 606 ALLNEHGAAQEQLNKIRDSYAKLLGHQN--LKQKIKHV-----VKLKDENSQLKSEVSKL 658
L E AAQ+ D+ + L QN LK K++ + K K S L++++ +L
Sbjct: 1773 -LAAERSAAQKS-----DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQL 1826
Query: 659 RCQL---AKKKQSETKLQEELNKVL 680
QL AK++ + KL K L
Sbjct: 1827 EEQLEQEAKERAAANKLVRRTEKKL 1851
Score = 108 bits (270), Expect = 2e-23
Identities = 139/660 (21%), Positives = 303/660 (45%), Gaps = 59/660 (8%)
Query: 39 QKSQRFKQQKESKQNLNVDK---DTTLPASARKVKSSESKESQKNDKDLKILEKEI---- 91
++ +R QQ ++N+ ++ +T L A A ++++ + + Q+ ++ L LE +
Sbjct: 876 EEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE 935
Query: 92 ---RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN- 147
++L E+ IQDLE +L++ E EK + A +E++++ L N
Sbjct: 936 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 995
Query: 148 ------ELLKSKFSENGNQ-KNLRILSLELMKLRNKRETKMRGM---MAKQEGMEMKLQV 197
+L++ + +E +Q + L K+RNK+E + + + K+E +L+
Sbjct: 996 KFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055
Query: 198 TQRSLE----ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISC----ASDQVEK 249
+R L+ + Q +IA+L+ ++ ++ + ++ E + L ++ + A V +
Sbjct: 1056 AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115
Query: 250 YKLDIAQLEENL---KEKNDEILSLKQSLEENIVILSKQVE---DLNVKCQLLEKEKEDH 303
+ IA+L+E+ K ++ K+ L E + L ++E D Q L ++E
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175
Query: 304 VNRNR----EHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 359
V + E +N A++Q+++Q+ +E + ++ + + L++ K+ + +++
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 360 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 419
L + + + K E + K+ ++ +L K + +RL +L E+A EL +
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 420 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 479
L +EAE + A A+L +S +Q +++ + K +S I L+ E +S
Sbjct: 1296 L--EEAEKKGIKFAKDAASL------ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Query: 480 LQEKAAKAGKNAEDVQHQILATESSNQEYVRML-LDLQTKSALKETEIKEITVSFLQKIT 538
LQE+ + + ++++ Q+LA +S + + + DL T +L+E + +K+
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK---------KKLL 1398
Query: 539 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 598
L Q+ E+ + E K + +LT +++ R + L K K F QL
Sbjct: 1399 KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD-QLL 1457
Query: 599 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKL 658
A E A E E + +++ A L + L++ ++ + + +N QL++++ L
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLA-RALEEALEAKEEFERQNKQLRADMEDL 1516
Score = 105 bits (262), Expect = 1e-22
Identities = 155/725 (21%), Positives = 322/725 (44%), Gaps = 96/725 (13%)
Query: 26 VKTLEVLKGPVSFQKSQRFKQQKESKQNLNV-DKDTTLPASARKVKSSESKESQKNDKDL 84
+K ++++ ++ SQ ++++++K + +K + + + E K Q+ +K
Sbjct: 998 IKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK 1057
Query: 85 KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALR--EKTSLSANNAT-----LE 137
+ L+ E L + +I +L+ +L K E L AL + +L NNA L+
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQ 1117
Query: 138 KQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV 197
Q+ EL E K S N +K R LS EL L+ + E + A+QE
Sbjct: 1118 AQIAELQEDFE--SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR------ 1169
Query: 198 TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY----IEEISCASDQVEKYKLD 253
T+R E ++ K A +E+E + +++ + + + +EE+S +Q +++K +
Sbjct: 1170 TKREQEVAELKKA--------LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKAN 1221
Query: 254 IAQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVEDLNVKCQ---LLEKEKEDH 303
+ + ++ L+ N E+ +K E L QV++L+ K L E +
Sbjct: 1222 LEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK 1281
Query: 304 VNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF 363
++ + +N++ ++ ++K I ++ L+ + LLQ+E +L ++
Sbjct: 1282 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL 1341
Query: 364 QEEM--VKEKNLFEEELKQTLD--------ELDKLQQKEEQAERLVKQLEEEAKSRAEEL 413
+EE ++E+ EEE ++ L+ +L ++K + ++ LEE K ++
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401
Query: 414 KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMV----------QSLEDVTAQFESY- 462
+ L ++L+ K +K + LQ++ D + +LE +F+
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNR----LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457
Query: 463 ---KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKS 519
K+++A E+ + +EK KA A ++ + A E ++ ++ D++
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLM 1517
Query: 520 ALKET------EIKEITVSFLQKITDLQNQLKQQE------EDFRKQLE-DEEGRKAEKE 566
+ K+ E+++ + Q++ +++ QL++ E ED + +LE + + KA+ E
Sbjct: 1518 SSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFE 1577
Query: 567 N---TTAELTEE-----INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQL 618
T E EE I + R L EL ++ K L + A + + + L + A E
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAV-ASKKKMEIDLKDLEAQIEAA 1636
Query: 619 NKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 678
NK RD K L + L+ ++K + +E + E+ A+ K+SE KL+ +
Sbjct: 1637 NKARDEVIKQL--RKLQAQMKDYQRELEEARASRDEI------FAQSKESEKKLKSLEAE 1688
Query: 679 VLGIK 683
+L ++
Sbjct: 1689 ILQLQ 1693
Score = 103 bits (258), Expect = 4e-22
Identities = 171/744 (22%), Positives = 318/744 (42%), Gaps = 124/744 (16%)
Query: 68 KVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKT 127
+V E + K+++ LK+ EK+ +V E ELE+ME + L EK
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKV---------------EGELEEMERKHQQLLEEKN 890
Query: 128 SLSAN--------------NATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKL 173
L+ A L + EL L+S+ E ++ +IL E K+
Sbjct: 891 ILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKKKM 948
Query: 174 RNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL 233
+ + + + ++EG KLQ+ + + E KI ++E +++ +E + + K EK
Sbjct: 949 QAHIQ-DLEEQLDEEEGARQKLQLEKVTAE---AKIKKMEEEILLLEDQ--NSKFIKEKK 1002
Query: 234 LEYIEEISCASDQVE-------------KYKLDIAQLEENLKEK---NDEILSLKQSLEE 277
L C+S E K ++ I+ LEE LK++ E+ K+ L+
Sbjct: 1003 LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 278 NIVILSKQVEDL-----NVKCQLLEKEKE------------DHVNRNREHNENLNAEMQN 320
L Q+ +L +K QL +KE+E H N + L A++
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122
Query: 321 LKQKFILEQQEREKLQQKELQIDSLLQQEK-ELSSSL-----HQKLCSFQEEMVKE-KNL 373
L++ F E+ R K ++++ + L+ K EL +L Q+L + +E+ V E K
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182
Query: 374 FEEELKQTLDELDKLQQKEEQA-ERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSA 432
EEE K ++ ++Q+ A E L +QLE+ + +A LE+ +G E + K A
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKAN----LEKNKQGLETD-NKELA 1237
Query: 433 AHTQATLLL-------QEKYDSMVQSLEDVTAQFESYKALTASEIEDL--KLEN-SSLQE 482
+ + ++K D+ VQ L ++ + + A + L +L+N S+L E
Sbjct: 1238 CEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297
Query: 483 KAAKAG----KNAEDVQHQILATESSNQEYVRMLLDL--------QTKSALKE--TEIKE 528
+A K G K+A ++ Q+ T+ QE R L+L + K++L+E E +E
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357
Query: 529 ITVSFLQKITDLQNQL---KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE 585
+ +++ LQ+QL K++ +D +E E K + L++ + + L Y++
Sbjct: 1358 ARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Query: 586 LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN------LKQKIK 639
L Q +LD V+ L+ L K + + +LL + +++ +
Sbjct: 1418 LEKTKNRLQQELDDLTVD----LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDR 1473
Query: 640 HVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TKLQEELNKVLGIKHFDPSKAFHHESK 696
+ +++ ++ S L L K++ E +L+ ++ ++ K D K H K
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD-DVGKNVHELEK 1532
Query: 697 ENFALKTPLKEGNTNCYRAPMECQ 720
AL+ ++E T E Q
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQ 1556
Score = 77.0 bits (188), Expect = 6e-14
Identities = 101/462 (21%), Positives = 209/462 (45%), Gaps = 79/462 (17%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKES-QKNDKDLKI-----------L 87
S R+ ++++ + +K+T + AR ++ + E+KE ++ +K L+ +
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523
Query: 88 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAA----LREKTSLSANNATLEKQLIEL 143
K + L + + A +++++++ T+LE++E L A LR + ++ A A E+ L
Sbjct: 1524 GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR 1583
Query: 144 TRTNEL-----------LKSKFSENGNQKNLRILSLELMKLRNK-------RETKMRGMM 185
NE L+++ + Q+ L + S + M++ K K R +
Sbjct: 1584 DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 186 AKQ-EGMEMKLQVTQRSLEES---------------------QGKIAQLEGKLVSIEKEK 223
KQ ++ +++ QR LEE+ + +I QL+ +L S E+ +
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703
Query: 224 IDEKSETEKLLEYIEEI----SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENI 279
+ E ++L + I S D+ + + IAQLEE L+E+ + L +
Sbjct: 1704 RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT 1763
Query: 280 VILSKQVEDLNVK--CQLLEKEKEDHVNRNREH-NENLNAEMQNL----KQKFILEQQER 332
+ QV+ LN + + +K D+ + E N+ L A++Q L K KF +
Sbjct: 1764 L----QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF---KATI 1816
Query: 333 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKE 392
L+ K Q++ L+QE + ++ + KL E+ +KE + E+ ++ D+ +++
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAAN-KLVRRTEKKLKEIFMQVEDERR---HADQYKEQM 1872
Query: 393 EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 434
E+A +KQL+ + + EE + + EL+ ++ A+
Sbjct: 1873 EKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEAN 1914
Score = 70.9 bits (172), Expect = 4e-12
Identities = 82/400 (20%), Positives = 178/400 (44%), Gaps = 41/400 (10%)
Query: 332 REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF-----EEELKQTLDELD 386
R+ +K+ Q+ +L ++ ++ L + + K K L EEEL+ +EL
Sbjct: 803 RKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELL 862
Query: 387 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLK------GKEAELEKSSAAHTQATLL 440
K+++K+ + E ++++E + + EE +L E+L+ + E+ AA Q
Sbjct: 863 KVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEE 922
Query: 441 LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE-------NSSLQEKAAKAGKNAED 493
+ +S V+ E+ ++ K + I+DL+ + LQ + A +
Sbjct: 923 ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKK 982
Query: 494 VQHQILATESSNQEYV--RMLLD---LQTKSALKETEIKEITVSFLQK-----ITDLQNQ 543
++ +IL E N +++ + L++ + S L E E K ++ ++ I+DL+ +
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 544 LKQQE---EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 600
LK++E ++ K +G + ++ AEL +I++ +L + + + + D
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDE 1102
Query: 601 EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC 660
+ K L Q Q+ ++++ + +N +K K L +E LK+E+
Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR--DLSEELEALKTELEDTLD 1160
Query: 661 QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFA 700
A +++ TK ++E+ ++ KA E+K + A
Sbjct: 1161 TTAAQQELRTKREQEVAEL--------KKALEEETKNHEA 1192
Score = 70.1 bits (170), Expect = 7e-12
Identities = 94/438 (21%), Positives = 188/438 (42%), Gaps = 42/438 (9%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKESQ---- 78
+V LE K + Q + Q +E + L +D L + + +K+ ++ Q
Sbjct: 1526 NVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585
Query: 79 KNDKDLKILEKEIRVLLQERGAQDRRIQ---------DLETELEKMEARLNAALREKTSL 129
+N++ ++L K++R L E +D R Q +E +L+ +EA++ AA + + +
Sbjct: 1586 QNEEKKRLLIKQVREL--EAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 130 SANNATLEKQLIELTRTNELLKSKFSE-----NGNQKNLRILSLELMKLRNKRETKMRGM 184
L+ Q+ + R E ++ E ++K L+ L E+++L+ + + R
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703
Query: 185 M-AKQEGMEMKLQVTQRSLEESQ--GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS 241
A+QE E+ ++T + +S + +LE ++ +E+E +E+S E L + + +
Sbjct: 1704 RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT 1763
Query: 242 CASDQVEKY---KLDIAQLEEN----LKEKNDEILSLKQSLEENIVILSKQ-VEDLNVKC 293
D + + AQ +N L+ +N E+ + Q LE + K + L K
Sbjct: 1764 LQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKI 1823
Query: 294 QLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELS 353
LE++ E N+ + + LK+ F+ + ER Q + Q++ + K+L
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLK 1883
Query: 354 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 413
L + EE N +L++ ELD + E R V L+ + R +
Sbjct: 1884 RQLEE-----AEEEATRANASRRKLQR---ELDDATEANEGLSREVSTLKNRLR-RGGPI 1934
Query: 414 KLLEEKLKGKEAELEKSS 431
+ ++ LE +S
Sbjct: 1935 SFSSSRSGRRQLHLEGAS 1952
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 123 bits (309), Expect = 5e-28
Identities = 169/763 (22%), Positives = 329/763 (43%), Gaps = 108/763 (14%)
Query: 38 FQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQE 97
F K + ++S++ V+ + S K+ + + + D+ + LEKEI+ L +E
Sbjct: 762 FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEE 821
Query: 98 RGAQDRRIQD-----------LETELEKMEARLNAA---------LREKTSLSANNATLE 137
Q ++ L ELE++++ A EKT L N ++
Sbjct: 822 SVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQ 881
Query: 138 KQLIELTRT-----NELLKSKFSENGN------QKNLRILSLELMKLRN---KRETKMRG 183
+ + T + NE K E+ N QK LR EL+ L++ K +
Sbjct: 882 VEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKND 941
Query: 184 MMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCA 243
++ + +E K++ ++ +E + KI +++ V +KE + ET+ + E +E +
Sbjct: 942 PLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSE 1001
Query: 244 SDQVEKYKLDIAQLEENLK------EKNDEILSLKQ----SLEENIVILSKQVEDLNVKC 293
DQ+ D+ Q E+ K EK E L +++ + E I L++Q+ + ++C
Sbjct: 1002 KDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQC 1061
Query: 294 QLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK-EL 352
+ + + ED + R N L + ILE Q + + KEL+ + L +++K +
Sbjct: 1062 ETINSDNEDLLARIETLQSN-----AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKE 1116
Query: 353 SSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA----------ERLVKQ- 401
++ +L Q ++ KEK ++L++T+ EL+ +++ +Q ERL+K+
Sbjct: 1117 HATTVNELEELQVQLQKEK----KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172
Query: 402 -------------LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL----QEK 444
LE+E K + ++ + L+E++ ++ +++ +T+ LL +E
Sbjct: 1173 NQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKEL 1232
Query: 445 YDSMVQSLEDVTAQFESYKALTAS--EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 502
DS + + Q L AS ++E K++ + + + K ++ + Q T
Sbjct: 1233 ADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTL 1292
Query: 503 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 562
S+ Q+ V LQ + + E +T F + N LKQQ+ Q E EG K
Sbjct: 1293 SAYQQRVTA---LQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAE-TEGAK 1348
Query: 563 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK-I 621
E+E+ +L ++L K + Q L E Q L +EH E+ NK +
Sbjct: 1349 QEREHL-----------EMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKML 1397
Query: 622 RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 681
+++ +K L++K+ ++ EN +KSE ++ QL + + + + L
Sbjct: 1398 QETVSK---EAELREKL---CSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQ 1451
Query: 682 IKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 724
+H + + + A LK T R+P+ Q+S K
Sbjct: 1452 EEHRKTVETLQQQLSKMEAQLFQLKNEPTT--RSPVSSQQSLK 1492
Score = 101 bits (252), Expect = 2e-21
Identities = 141/680 (20%), Positives = 301/680 (44%), Gaps = 82/680 (12%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKE--IRVLLQERGAQDR 103
+ K + + ++ L +V + SK N+K+ +++ ++ LL+++ +DR
Sbjct: 863 EMKNANEKTRLENQNLL-IQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDR 921
Query: 104 RIQD--LETELEKMEARLNAALREKTSLSANNATLEKQLIELT-RTNEL----LKSKFSE 156
R + L+ L K + N L L LEK+ E + N++ +K+K
Sbjct: 922 RAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKEL 981
Query: 157 NGNQKNLRILSLELMKLRNKRE---TKMRGMMAKQEG-----MEMKLQVTQRSLEESQG- 207
+ ++K + + EL LR++++ MR ++ E +E + Q Q +E+ +
Sbjct: 982 DSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERAN 1041
Query: 208 -------------KIAQLEGKLVSIEKEKIDEKSET----EKLLEY-IEEISCASDQVEK 249
+ + L+ + ++ + E + + ET KLLE I E+ A V+K
Sbjct: 1042 NFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDK 1101
Query: 250 YKLDIAQLEENLKEKN-----DEILSLKQSLEENIVILSKQVEDLNV------KCQLLEK 298
+L+ +L++ K K +E+ L+ L++ L K +++L + + L+
Sbjct: 1102 -ELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNM 1160
Query: 299 EKEDHVNRNREHNENL---NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSS 355
E D+ +E N+ L N ++++L+Q+ +++Q++E LQ++ + S +QQ +E ++
Sbjct: 1161 EIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTK 1220
Query: 356 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 415
+ Q L ++E+ K + L +L+ ++Q E QL E + +
Sbjct: 1221 IKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHK---- 1276
Query: 416 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 475
+ E LK + +++ +A+ Q LQE+ + VT++FESYK + ++ K
Sbjct: 1277 IHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK- 1335
Query: 476 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK-EITVSFL 534
N S+ + + K +E++ ML+D Q K L++++ +I VS L
Sbjct: 1336 -NKSMSQAETEGAK--------------QEREHLEMLID-QLKIKLQDSQNNLQINVSEL 1379
Query: 535 QKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNK-TKPF 593
Q LQ++ E K L++ ++AE + E + + + ++ T
Sbjct: 1380 Q---TLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQN 1436
Query: 594 QLQLDAFEVEKQALLNEH----GAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENS 649
++ ++F + + L EH Q+QL+K+ +L + + LK+
Sbjct: 1437 EVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRE 1496
Query: 650 QLKSEVSKLRCQLAKKKQSE 669
+ +++ L +++ E
Sbjct: 1497 RRNTDLPLLDMHTVTREEGE 1516
Score = 94.0 bits (232), Expect = 4e-19
Identities = 133/606 (21%), Positives = 273/606 (45%), Gaps = 74/606 (12%)
Query: 142 ELTRTNELLKSKFSENGNQKNLRILSLEL-MKLRNKRETKMRGMMAKQEGMEMKLQV--- 197
EL + E L+SK G ++ L+ L L K ET+ + + K+E ++MK +V
Sbjct: 50 ELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDS 109
Query: 198 ------TQRSLEESQ----GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQV 247
+ LE+S +I L+ +L+++ + ++K+ +K LE E ++ +
Sbjct: 110 VTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLE--EAMNTQLELS 167
Query: 248 EKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRN 307
E+ K E+N+K+ +EI ++ EE I+ L KQ++ + + + ++ + N
Sbjct: 168 EQLKFQ-NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEAN 226
Query: 308 REH-NENLNAEMQNLKQKFILEQQEREKLQQKELQID-SLLQQEKELSSSLHQKLCSFQE 365
+H +N+N+ + L Q + Q+E ++L QI+ S + E E++ KL +E
Sbjct: 227 SQHYQKNINSLQEELLQLKAIHQEEVKELM---CQIEASAKEHEAEIN-----KLNELKE 278
Query: 366 EMVKEKNLFEEELKQTLD-ELDKLQQKEEQAER-------------LVKQ-LEEEAKSRA 410
+VK+ E+ +++ + EL+ L++ A + V+Q + E+ K
Sbjct: 279 NLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLE 338
Query: 411 EELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASE- 469
+ LK LE + + E+ + + + Q D ED+ +F+ + L A E
Sbjct: 339 DTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDL--EFKINELLLAKEE 396
Query: 470 ----IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETE 525
IE LK E + L ++ E ++ + + +Q+ + L ++ L ++E
Sbjct: 397 QGCVIEKLKSELAGLNKQFC---YTVEQHNREVQSLKEQHQKEISEL----NETFLSDSE 449
Query: 526 IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE 585
+++T+ F +I L+ Q + +++ ++ + + E + E EL E K +E
Sbjct: 450 KEKLTLMF--EIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFES 507
Query: 586 LYNKTKPFQLQLDAFEVEK--QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK 643
+ Q D E+++ + E A E +N+++ KLL Q L ++++ +K
Sbjct: 508 MKQ-----QQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIK 562
Query: 644 -LKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG-IKHFDPSKAFHHESKENFAL 701
L+++N +S+ L + + L EE + + +K+ HE +NF
Sbjct: 563 NLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKN-------SHEEMDNFHK 615
Query: 702 KTPLKE 707
K +E
Sbjct: 616 KCEREE 621
Score = 89.4 bits (220), Expect = 1e-17
Identities = 132/652 (20%), Positives = 283/652 (43%), Gaps = 83/652 (12%)
Query: 66 ARKVKSSESKES-QKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALR 124
A + K SE K + QK ++ + E+ L+ + + ++ L+ E+EK+ +
Sbjct: 140 AVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQIL 199
Query: 125 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 184
+AT +++ +T+ ++++ + QKN+ L EL++L+ + +++ +
Sbjct: 200 YLQKQL--DATTDEKKETVTQLQNIIEA--NSQHYQKNINSLQEELLQLKAIHQEEVKEL 255
Query: 185 MAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS 244
M + E S +E + +I KL +++ + + +EK ++
Sbjct: 256 MCQIEA----------SAKEHEAEI----NKLNELKENLVKQCEASEKNIQ--------- 292
Query: 245 DQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEK- 300
+KY+ ++ L + N + L+EN +++++V+ L + LE +
Sbjct: 293 ---KKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHS 349
Query: 301 --EDHVNRNREHNENLNAEMQNLKQKFILEQQE-----REKLQQKELQIDSLLQQEKELS 353
+D V L + Q++K +F E+++ E L KE Q ++++ K
Sbjct: 350 ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ-GCVIEKLKSEL 408
Query: 354 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 413
+ L+++ C E+ +E +E+ ++ + EL++ + + E+L E+
Sbjct: 409 AGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF---------EI 459
Query: 414 KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDL 473
+ L+E+ + + E +++ + +++ + +S ++ +FES K AS++ +L
Sbjct: 460 QGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHEL 519
Query: 474 K-------LENSSLQEKAAK-AGKNAEDVQHQILATESSN-------QEYVRMLLDLQTK 518
+ E +L E + G+N + + Q L E N + V +L Q
Sbjct: 520 QQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRD 579
Query: 519 SALKETEIKEITVSFLQKITDLQNQLKQQEED---FRKQLEDEE------GRKAEKE-NT 568
+ LKE E K S ++ D N+LK E+ F K+ E EE G+K E+
Sbjct: 580 TMLKELEGK--INSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQY 637
Query: 569 TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL 628
+EL +++N+ EE + +L+ V+ + L + ++ + + KL
Sbjct: 638 NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKL 697
Query: 629 LGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 680
+ + V + E+ LK ++ QL KK Q + Q+ LNK+L
Sbjct: 698 SSEKKQLSRDLEVFLSQKEDVILKEHIT----QLEKKLQLMVEEQDNLNKLL 745
Score = 78.6 bits (192), Expect = 2e-14
Identities = 148/719 (20%), Positives = 290/719 (40%), Gaps = 134/719 (18%)
Query: 77 SQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELE----KMEARLNAALREKTSLSAN 132
SQ K++ L++E LLQ + +++L ++E + EA +N K +L
Sbjct: 227 SQHYQKNINSLQEE---LLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQ 283
Query: 133 NATLEKQLIELTRTNELLKSKFSENGNQKN--LRILSLELMKLRNKRETKMRGMMAKQEG 190
EK + + K + N NQ N IL E + K++ + +
Sbjct: 284 CEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKE 343
Query: 191 MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETE----KLLEYIEEISCASDQ 246
+E + + + + +LE I+ E E+ + E +LL EE C
Sbjct: 344 LESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV--- 400
Query: 247 VEKYKLDIAQLEEN----LKEKNDEILSLKQSLEENIVILSK---------------QVE 287
+EK K ++A L + +++ N E+ SLK+ ++ I L++ +++
Sbjct: 401 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 460
Query: 288 DLNVKCQLLEKEKEDHVNRNREHNE--------------NLNAEMQNLKQKFILEQQE-R 332
L +C+ L++EK++ + E ++ E +++KQ+ + E +
Sbjct: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
Query: 333 EKLQQKELQIDSLLQ-------------QEKELSSSLHQKLCSFQEE------------- 366
+KL+ + D+LL+ ++EL L + + QE+
Sbjct: 521 QKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT 580
Query: 367 -----------MVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 415
+ +EK+ F +LK + +E+D +K E+ ERL+ +L ++ + +
Sbjct: 581 MLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE 640
Query: 416 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE---SYKALTASEIED 472
LE+K+ LE++ L+EK D Q LE + Q + K + ++E++
Sbjct: 641 LEQKVNELTGGLEET----------LKEK-DQNDQKLEKLMVQMKVLSEDKEVLSAEVKS 689
Query: 473 LKLENSSLQEKAAKAGKNAE---DVQHQILATESSNQEYVRMLLDLQTKSAL-KETEIKE 528
L EN+ L + + ++ E + ++ E Q ++ L ++ + L K E ++
Sbjct: 690 LYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ 749
Query: 529 ITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYN 588
+ F +K Q F K++ E +E+++ L + EE N
Sbjct: 750 VQKLF----------VKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCN 799
Query: 589 KTKPFQLQLDAFEVEKQ-ALLNEHGAAQ-EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKD 646
FQ E+EK+ L E Q E+L + Y + V L+
Sbjct: 800 LA--FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYE------------QEKVLLRK 845
Query: 647 ENSQLKSEVSKLRCQLAKKKQSETKLQ-EELNKVLGIKHFDP--SKAFHHESKENFALK 702
E +++SE L+ L + K + K + E N ++ ++ SK+ H KE +K
Sbjct: 846 ELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIK 904
Score = 68.2 bits (165), Expect = 3e-11
Identities = 102/539 (18%), Positives = 235/539 (43%), Gaps = 66/539 (12%)
Query: 174 RNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL 233
++K ET + + K +M L +++++ + +LE ++ E++ K TE
Sbjct: 19 KSKLETLPKEDLIKFAKKQMML------IQKAKSRCTELEKEI-----EELRSKPVTEGT 67
Query: 234 LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKC 293
+ I+ ++ ++++ L+ A+ E+ E + +KQ +E+++ + ++L
Sbjct: 68 GDIIKALT---ERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKEL---- 120
Query: 294 QLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELS 353
++ H+N +E ENL E+ ++ K+ ++ +K ++ + L ++ +
Sbjct: 121 ------EQSHINYVKEI-ENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ 173
Query: 354 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLVKQLEEEAK----- 407
++ + QEE+ K + FEE++ +LD +K+E +L +E ++
Sbjct: 174 NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKN 233
Query: 408 --SRAEELKLL----EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLE-------- 453
S EEL L +E++K ++E S+ H L E +++V+ E
Sbjct: 234 INSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQK 293
Query: 454 DVTAQFESYKALTASEIED------LKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 507
+ E+ + T++ +D L EN+ +++ + K+ ED ++ + S ++
Sbjct: 294 KYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKD 353
Query: 508 YVRMLLDLQTKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEGRKAE 564
V + +L+ K + IK+ F + DL+ N+L +E+ +E + A
Sbjct: 354 EVTYMNNLKLKLEMDAQHIKD---EFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAG 410
Query: 565 KENTTAELTEEINKWRLLYEELYNK--TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKI- 621
E+ N+ +E + K ++ + L E EK L+ E +EQ +
Sbjct: 411 LNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQ 470
Query: 622 RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 680
++ +L +++L++ ++ + ++L K+ + KQ + EL + L
Sbjct: 471 QEKQEAILNYESLREIMEIL------QTELGESAGKISQEFESMKQQQASDVHELQQKL 523
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 123 bits (308), Expect = 7e-28
Identities = 121/546 (22%), Positives = 249/546 (45%), Gaps = 50/546 (9%)
Query: 171 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 228
MKL K + ++ ++E MK + T+ L +++ K +LE K+V++ +EK D +
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 229 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 281
+ + + + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 894 QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 282 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 341
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+ Q
Sbjct: 954 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 342 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 401
LQ E++ ++L + ++++ + E+E K +D L++ + + E +K
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD----LERAKRKLEGDLKL 1065
Query: 402 LEEEAKSRAEELKLLEEKLKGKEAELE--KSSAAHTQA-TLLLQEKYDSMVQSLEDVTAQ 458
+E + + L EKLK KE E+ + QA + LQ+K + +E++ +
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEE 1125
Query: 459 FESYKALTA---SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 515
E+ +A A + DL E + E+ +AG QI + E+ +M DL
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDL 1182
Query: 516 QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 575
+ + E + + +L Q+ + +++LE E+ + N A E
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQR-VKQKLEKEKSELKMEINDLASNMET 1241
Query: 576 INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL------ 629
++K + +E++ + ++ E E+Q L+NE A + +L+ +++ L
Sbjct: 1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 630 ------GHQNLKQKIKHVVKLKDENSQLKSEVSK-----------LRCQLAKKKQSETKL 672
G Q Q+I+ + + +E ++ KS ++ LR Q ++++++ +L
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAEL 1361
Query: 673 QEELNK 678
Q ++K
Sbjct: 1362 QRGMSK 1367
Score = 114 bits (284), Expect = 4e-25
Identities = 141/665 (21%), Positives = 294/665 (44%), Gaps = 69/665 (10%)
Query: 68 KVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKT 127
K+K + + + + ++ K+ R L E + I DLE L K+E +A +
Sbjct: 922 KIKEVTERAEDEEEINAELTAKK-RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980
Query: 128 SLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLR--NKRETKMRGMM 185
+L+ A L++ + +LT+ + L + +Q+ L L +E K+ K +TK+ +
Sbjct: 981 NLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQV 1035
Query: 186 AKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE----EIS 241
EG + + LE ++ K LEG L ++ +D +++ ++L E ++ E+S
Sbjct: 1036 DDLEGSLEQEKKLCMDLERAKRK---LEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMS 1092
Query: 242 CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 301
++E + QL++ +KE I L++ +E +K + + L +E E
Sbjct: 1093 NLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD----LSRELE 1148
Query: 302 DHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQID----SLLQQEKELSSSLH 357
+ R E +A+++ K++ Q+ R L++ LQ + +L ++ + + L
Sbjct: 1149 EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELG 1208
Query: 358 QKLCSFQ---EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE---EAKSRAE 411
+++ S Q +++ KEK+ + E+ ++ + + + E++ + LE+ E K++ E
Sbjct: 1209 EQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEE 1268
Query: 412 ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIE 471
E + L +L ++A L S ++ L EK D+MV L F ++E
Sbjct: 1269 EQQRLINELSAQKARLHTESGEFSRQ---LDEK-DAMVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 472 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITV 531
+ S+L A + + ++ Q + + E R + ++ A T+ + +
Sbjct: 1325 EETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAI 1384
Query: 532 SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE------ 585
+++ + + +L Q+ +D + +E + A E T L E+ + E
Sbjct: 1385 QRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACI 1444
Query: 586 -LYNKTKPFQLQL-------DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGH------ 631
L K + F L + + E +A E + +L K++++Y + L H
Sbjct: 1445 ALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKR 1504
Query: 632 --QNLKQKI-----------KHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 678
+NL+Q+I KH+ +L+ QL E S+L+ L +++E L+ E K
Sbjct: 1505 ENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSL---EEAEASLEHEEGK 1561
Query: 679 VLGIK 683
+L I+
Sbjct: 1562 ILRIQ 1566
Score = 108 bits (269), Expect = 2e-23
Identities = 133/673 (19%), Positives = 287/673 (42%), Gaps = 75/673 (11%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDL 84
D+ LE+ V +K + K + + D T+ ++ K+ + Q D DL
Sbjct: 957 DIDDLELTLAKVEKEKHATENKVKNLTEEM-AGLDETIAKLTKEKKALQEAHQQTLD-DL 1014
Query: 85 KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELT 144
++ E ++ L + + ++++ DLE LE+ + R K L + ++ ++
Sbjct: 1015 QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTE 1074
Query: 145 RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 204
+ L K L+ E+ L+ K E + A ++ K++ Q +EE
Sbjct: 1075 NDKQQLNEK---------LKKKEFEMSNLQGKIEDE----QALAIQLQKKIKELQARIEE 1121
Query: 205 SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCA-SDQVEKYKLDIAQ------- 256
+ +I EK++ D E E++ E +EE A S Q+E K A+
Sbjct: 1122 LEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRD 1181
Query: 257 LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKED---HVNRNREHNEN 313
LEE+ + +L++ +++ L +Q++ L Q LEKEK + +N + E
Sbjct: 1182 LEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMET 1241
Query: 314 LNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSF------QEEM 367
++ N ++ + + +++ KE + L+ + + LH + F ++ M
Sbjct: 1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 368 VKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAEL 427
V + + ++ Q ++EL + ++E +A+ + + A+ + L+ E+ + +AEL
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAEL 1361
Query: 428 EKSSAAHTQATLLLQEKYDS-MVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAK 486
++ + + KY++ +Q E++ E K A ++D + ++ K A
Sbjct: 1362 QRGMSKANSEVAQWRTKYETDAIQRTEEL----EEAKKKLAQRLQDAEEHVEAVNSKCAS 1417
Query: 487 AGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQ 546
K + +Q+++ +++D++ +A L +
Sbjct: 1418 LEKTKQRLQNEV----------EDLMIDVERSNAACIA-------------------LDK 1448
Query: 547 QEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQA 606
++ +F K L + K + E T AEL + R L EL+ ++ LD E K+
Sbjct: 1449 KQRNFDKVLAE---WKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKR- 1504
Query: 607 LLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK 666
E+ Q++++ + + A+ H + +K+K +L E S+L++ + + L ++
Sbjct: 1505 ---ENKNLQQEISDLTEQIAEGGKHIHELEKVKK--QLDHEKSELQTSLEEAEASLEHEE 1559
Query: 667 QSETKLQEELNKV 679
++Q ELN+V
Sbjct: 1560 GKILRIQLELNQV 1572
Score = 104 bits (260), Expect = 3e-22
Identities = 137/660 (20%), Positives = 297/660 (45%), Gaps = 70/660 (10%)
Query: 70 KSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQ--DLETELEKMEARLNAALREKT 127
+S+ E+ K + K+ +KE + + +D + L+ ++++++AR+ E
Sbjct: 1068 ESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIE 1127
Query: 128 SLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAK 187
+ A+ A EKQ +L+R E + + E G + +I ++ KRE + + M
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI------EMNKKREAEFQKMRRD 1181
Query: 188 QEGMEMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ 246
E ++ + T +L + +A+L ++ S+++ K + E +L I +++ +
Sbjct: 1182 LEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMET 1241
Query: 247 VEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK---EKEDH 303
V K K + ++ L+++ EI + ++ + I LS Q L+ + + EK+
Sbjct: 1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 304 VNRNREHNENLNAEMQNLKQKFILEQQEREK------LQQKELQIDSLLQQ---EKELSS 354
V++ + +++ LK++ LE++ + K LQ D L +Q E+E +
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQ--LEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKA 1359
Query: 355 SLHQKLCSFQEEMVKEKNLFEEELKQTLDELD----KLQQKEEQAERLVKQLEEEAKSRA 410
L + + E+ + + +E + Q +EL+ KL Q+ + AE V+ + + S
Sbjct: 1360 ELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLE 1419
Query: 411 EELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEI 470
+ + L+ +++ ++E+S+A A + L +K ++ + V A+++ T +E+
Sbjct: 1420 KTKQRLQNEVEDLMIDVERSNA----ACIALDKKQ----RNFDKVLAEWKQKYEETQAEL 1471
Query: 471 EDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEIT 530
E + E+ SL + K E+ + + N+ + + DL + A I E+
Sbjct: 1472 EASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELE 1531
Query: 531 VSFLQKITDLQNQLKQQEEDFRKQLEDEEGR-----------KAEKENTTAELTEEINKW 579
+++ +++L+ E+ LE EEG+ K+E + AE EE+++
Sbjct: 1532 -KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQL 1590
Query: 580 R---LLYEELYNKTKPFQLQL--DAFEVEK--QALLNE--------HGAAQEQLNKIRDS 624
+ L E T +++ DA ++K + LNE + A E L +R++
Sbjct: 1591 KRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNT 1650
Query: 625 YAKLLGHQ-NLKQKIKHVVKLKDENSQ-------LKSEVSKLRCQLAKKKQSETKLQEEL 676
L Q +L I+ LK++ + +++EV +LR L + ++ ++EL
Sbjct: 1651 QGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQEL 1710
Score = 87.0 bits (214), Expect = 5e-17
Identities = 144/661 (21%), Positives = 284/661 (42%), Gaps = 101/661 (15%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKN-DKDLKILEKEIRVLLQE 97
Q+++ Q+ SK N V + T + ++ E +E++K + L+ E+ + + +
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 98 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 157
+ ++ Q L+ E+E + + + +L +K L E + E +++
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELE-- 1472
Query: 158 GNQKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEMKLQVTQRSLEESQG--KIAQLEG 214
+QK R LS EL K++N E + + K+E ++ +++ + + ++G I +LE
Sbjct: 1473 ASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELE- 1531
Query: 215 KLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS 274
++K+ EKSE + LE E AS + E+ K+ QLE N +K
Sbjct: 1532 ---KVKKQLDHEKSELQTSLEEAE----ASLEHEEGKILRIQLELN---------QVKSE 1575
Query: 275 LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK 334
++ I ++++ L K +H+ L+AE+++ ++++
Sbjct: 1576 IDRKIAEKDEELDQL----------KRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD 1625
Query: 335 LQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQ 394
L + E+Q++ +Q E +L + ++K+ L L + D L+++
Sbjct: 1626 LNEMEIQLNHANRQAAEALRNLRNT-----QGILKDTQL---HLDDAIRGQDDLKEQLAM 1677
Query: 395 AERLVKQLEEEAKSRAEELKLLEEKLKGKEAEL----EKSSAAHTQATLLLQEKYDSMVQ 450
ER ++ E + L+ E K E EL E+ HTQ T L+ K +
Sbjct: 1678 VERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTK-----K 1732
Query: 451 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 510
LE +Q + E+ED+ E + +EKA KA +A + ++ + ++ R
Sbjct: 1733 KLETDISQIQG-------EMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 511 M-------------LLDLQTKSALK--ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL 555
M LD + ALK + +I+++ + ++++++ K E K L
Sbjct: 1786 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAV-KGL 1844
Query: 556 EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 615
E R E T E + I + + L ++L K K ++ Q A E E+Q+ +N
Sbjct: 1845 RKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQ--AEEAEEQSNVN------ 1896
Query: 616 EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL-KSEVSKLRCQLAKKKQSETKLQE 674
L K R K++H ++ E + + +S+V+KLR K ++ TK+
Sbjct: 1897 --LAKFR--------------KLQHELEEAKERADIAESQVNKLR---VKSREVHTKVIS 1937
Query: 675 E 675
E
Sbjct: 1938 E 1938
Score = 66.6 bits (161), Expect = 8e-11
Identities = 91/435 (20%), Positives = 189/435 (43%), Gaps = 55/435 (12%)
Query: 22 GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKESQK 79
G + LE +K + +KS+ +E++ +L ++ L +VKS ++ +
Sbjct: 1523 GGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAE 1582
Query: 80 NDKDLKILEKE-IRVLLQERGAQDRRIQD----------LETELEKMEARLNAALREKTS 128
D++L L++ +RV+ + D I+ +E +L +ME +LN A R+
Sbjct: 1583 KDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAE 1642
Query: 129 LSANNATLEK-------QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKM 181
N + L + R + LK + + + NL + E+ +LR E
Sbjct: 1643 ALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANL--MQAEVEELRASLERTE 1700
Query: 182 RGM-MAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 228
RG MA+QE ++ +V T++ LE I+Q++G++ I +E ++
Sbjct: 1701 RGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQIQGEMEDIVQEA---RN 1754
Query: 229 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVED 288
EK + I + + +++++K + A LE K + L+ L+E + K +
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1814
Query: 289 LNVKCQLLEKEKEDHVNRNREHN----ENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 344
K + +E E V ++HN + L + +K+ +++R+ + + + +D
Sbjct: 1815 QIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1874
Query: 345 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 404
L + K EE ++ N+ + ++ EL++ +++ + AE V +L
Sbjct: 1875 LQTKVKAYKRQ--------AEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKL-- 1924
Query: 405 EAKSRAEELKLLEEK 419
KSR K++ E+
Sbjct: 1925 RVKSREVHTKVISEE 1939
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 122 bits (305), Expect = 2e-27
Identities = 134/550 (24%), Positives = 258/550 (46%), Gaps = 58/550 (10%)
Query: 171 MKLRNKRETKMRGMMAKQEGMEMKLQV--TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 228
MKL K + ++ ++E MK + + +LE+S+ + +LE K+VS+ +EK D +
Sbjct: 832 MKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQL 891
Query: 229 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND----------EILSLKQSLEEN 278
+ + + + + DQ+ K K+ QLE +KE N+ E+ + K+ LE+
Sbjct: 892 QVQAEQDNLNDAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 948
Query: 279 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 338
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 949 CSELKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDEIIAKLTKEKKALQEA 1004
Query: 339 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 398
Q LQ E++ +SL + ++++ + E+E K +D L++ + + E
Sbjct: 1005 HQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD----LERAKRKLEGD 1060
Query: 399 VKQLEEEAKSRAEELKLLEEKLKGKEAEL-EKSSAAHTQATLLLQ-----EKYDSMVQSL 452
+K +E + LEEKLK KE ++ +++S + L LQ ++ + ++ L
Sbjct: 1061 LKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEEL 1120
Query: 453 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML 512
E+ + +A DL E + E+ +AG A V QI + E+ +M
Sbjct: 1121 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAG-GATSV--QIEMNKKREAEFQKMR 1177
Query: 513 LDLQ--------TKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEGR 561
DL+ T +AL++ + ++I +LQ +L++++ +F+ +L+D
Sbjct: 1178 RDLEEATLQHEATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1236
Query: 562 -------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL---LNEH 611
KA E + L ++ N++R+ EE F Q + E L L E
Sbjct: 1237 MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK 1296
Query: 612 GAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK-QSET 670
A QL + + SY + + ++LK++++ K K+ + + ++ C L +++ + ET
Sbjct: 1297 EALISQLTRGKLSYTQQM--EDLKRQLEEEGKAKNALAH-ALQSARHDCDLLREQYEEET 1353
Query: 671 KLQEELNKVL 680
+ + EL +VL
Sbjct: 1354 EAKAELQRVL 1363
Score = 114 bits (285), Expect = 3e-25
Identities = 161/722 (22%), Positives = 301/722 (41%), Gaps = 101/722 (13%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERG 99
K Q + KE + L +++ +A+K K + E + KD+ LE + + +E+
Sbjct: 914 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED--ECSELKKDIDDLELTLAKVEKEKH 971
Query: 100 AQDRRIQDLETELEKMEARLNAALREKTSLS-ANNATLEKQLIELTRTNELLKSKFS--- 155
A + ++++L E+ ++ + +EK +L A+ L+ +E + N L KSK
Sbjct: 972 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQ 1031
Query: 156 -------------------ENGNQK---NLRILSLELMKLRN----------KRETKMRG 183
E +K +L++ +M L N K+E +
Sbjct: 1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQ 1091
Query: 184 MMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLEY 236
+K E ++ Q+ L+E+Q +I +LE +L +EK + D E E++ E
Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1151
Query: 237 IEEISCASD-QVEKYKLDIAQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVED 288
+EE A+ Q+E K A+ ++ ++ + L +L++ +++ L +Q+++
Sbjct: 1152 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1211
Query: 289 LNVKCQLLEKEKE------DHVNRNREHNENLNAEMQNLKQKFILEQQ------------ 330
L Q LEKEK D V N E A ++ + + LE Q
Sbjct: 1212 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRT--LEDQANEYRVKLEEAQ 1269
Query: 331 --------EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 382
+R KLQ + ++ L++++ L S L + S+ ++M K EEE K
Sbjct: 1270 RSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKN 1329
Query: 383 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 442
LQ + L +Q EEE +++AE ++L + K Q T L+
Sbjct: 1330 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1389
Query: 443 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 502
E + Q L+D E+ A +S L+ LQ + + E A +
Sbjct: 1390 EAKKKLAQRLQDAEEAVEAVNAKCSS----LEKTKHRLQNEIEDLMVDVERSNAAAAALD 1445
Query: 503 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 562
+ + ++L + + K ++E++ S ++ L +L + + + + LE E K
Sbjct: 1446 KKQRNFDKILAEWKQKYEESQSELE----SSQKEARSLSTELFKLKNAYEESLEHLETFK 1501
Query: 563 AEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-QL 618
E +N E LTE++ + EL K QL+ ++E Q+ L E A+ E +
Sbjct: 1502 RENKNLQEEISDLTEQLGEGGKNVHELEKVRK----QLEVEKLELQSALEEAEASLEHEE 1557
Query: 619 NKIRDSYAKLLGHQNLKQKIKHVVKLKDEN-SQLKSEVSKLRCQLAKKKQSETKLQEELN 677
KI + L +K +I+ + KDE Q K ++ L +ET+ + E+
Sbjct: 1558 GKILRAQ---LEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVL 1614
Query: 678 KV 679
+V
Sbjct: 1615 RV 1616
Score = 110 bits (275), Expect = 5e-24
Identities = 142/690 (20%), Positives = 300/690 (43%), Gaps = 89/690 (12%)
Query: 88 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL-TRT 146
EKE+ + +E G ++ E +++E ++ + L+EK L + L + R
Sbjct: 848 EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERC 907
Query: 147 NELLKSKFSENGNQKNL-------RILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQ 199
++L+K+K K + ++ EL + K E + + + +E+ L +
Sbjct: 908 DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE 967
Query: 200 RSLEESQGKIAQLEGKLVSIE----KEKIDEKSETEKLLEYIEEISCASDQV-----EKY 250
+ ++ K+ L ++ ++ K ++K+ E + ++++ D+V K
Sbjct: 968 KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKV 1027
Query: 251 KLD--IAQLEENLKEKNDEILSL---KQSLEENIVILSKQVEDL-NVKCQLLEKEKEDHV 304
KL+ + LE +L+++ + L K+ LE ++ + + + DL N K QL EK K+
Sbjct: 1028 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEF 1087
Query: 305 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ 364
+ N+++++ ++ + +L Q ++KL++ + +I+ L++E E + K+ +
Sbjct: 1088 DINQQNSK--------IEDEQVLALQLQKKLKENQARIEE-LEEELEAERTARAKVEKLR 1138
Query: 365 EEMVKEKNLFEEELKQ----TLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL 420
++ +E E L++ T +++ +++E + +++ + LEE L +K
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1198
Query: 421 KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY---KALTASEIEDLKLEN 477
AEL + + L+++ L+DVT+ E KA L+ +
Sbjct: 1199 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQA 1258
Query: 478 SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEIT---VSFL 534
+ + K +A ++ D Q ++ N E R L + KE I ++T +S+
Sbjct: 1259 NEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEE-------KEALISQLTRGKLSYT 1311
Query: 535 QKITDLQNQLKQQEED-----------------FRKQLEDEEGRKAEKENTTAELTEEIN 577
Q++ DL+ QL+++ + R+Q E+E KAE + ++ E+
Sbjct: 1312 QQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371
Query: 578 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 637
+WR YE T Q + + E K+ L A+E + + + L +K
Sbjct: 1372 QWRTKYE-----TDAIQ-RTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSL-------EK 1418
Query: 638 IKHVVKLKDENSQLKSEVSKLRCQLA---KKKQSETKLQEELNKVLGIKHFDPSKAFHHE 694
KH +L++E L +V + A KK+++ K+ E + K+ +
Sbjct: 1419 TKH--RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ----KYEESQSELESS 1472
Query: 695 SKENFALKTPLKEGNTNCYRAPMECQESWK 724
KE +L T L + N Y +E E++K
Sbjct: 1473 QKEARSLSTELFK-LKNAYEESLEHLETFK 1501
Score = 108 bits (271), Expect = 1e-23
Identities = 153/687 (22%), Positives = 314/687 (45%), Gaps = 75/687 (10%)
Query: 42 QRFKQQKESKQN---LNVDKDTT-----LPASARKVKSSESKESQKNDKDLKILE--KEI 91
QR KQ+ E +++ L +D T+ + A A K S + E Q N+ +K+ E + +
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL 1272
Query: 92 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 147
+R +L +LE+ EA ++ R K S + L++QL E +
Sbjct: 1273 NDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALA 1332
Query: 148 ----------ELLKSKFSENGNQKN--LRILSL---ELMKLRNKRETKMRGMMAKQEGME 192
+LL+ ++ E K R+LS E+ + R K ET + +E E
Sbjct: 1333 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD--AIQRTEELEE 1390
Query: 193 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 252
K ++ QR L++++ + + K S+EK K ++E E L+ +E + A+ ++K +
Sbjct: 1391 AKKKLAQR-LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1449
Query: 253 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 312
+ ++ K+K +E S +S ++ LS ++ K + +E +H+ + N+
Sbjct: 1450 NFDKILAEWKQKYEESQSELESSQKEARSLSTEL----FKLKNAYEESLEHLETFKRENK 1505
Query: 313 NLNAEMQNLKQ------KFILEQQE-REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE 365
NL E+ +L + K + E ++ R++L+ ++L++ S L++ + K+ Q
Sbjct: 1506 NLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQL 1565
Query: 366 EMVKEKNLFEEELKQTLDELDKLQQKEEQ-AERLVKQLEEEAKSRAEELKLLEEKLKGKE 424
E + K E +L + +E+++ ++ ++ + L L+ E +SR E L+ +++K++G
Sbjct: 1566 EFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR-VKKKMEGDL 1624
Query: 425 AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 484
E+E + + Q++ S+ L+D Q + A+ A+ +DLK + ++ +
Sbjct: 1625 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD--AVRAN--DDLKENIAIVERRN 1680
Query: 485 AKAGKNAEDVQHQILATESS----NQEYVR-----MLLDLQTKSALKETEIKEITVSFLQ 535
E+++ + TE S QE + LL Q S + + + E ++ LQ
Sbjct: 1681 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQ 1740
Query: 536 -KITDLQNQLKQQEEDFRKQLEDEE--GRKAEKENTTAELTEEINKWRLLYEELYNKTKP 592
++ + + + EE +K + D + +KE T+ E + K + K
Sbjct: 1741 SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK------NMEQTIKD 1794
Query: 593 FQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLK 652
Q +LD E E+ AL ++QL K+ +L G +QK ++ +K +
Sbjct: 1795 LQHRLD--EAEQIAL----KGGKKQLQKLEARVRELEGELEAEQK-RNAESVKGMRKS-E 1846
Query: 653 SEVSKLRCQLAKKKQSETKLQEELNKV 679
+ +L Q + K++ +LQ+ ++K+
Sbjct: 1847 RRIKELTYQTEEDKKNLLRLQDLVDKL 1873
Score = 74.3 bits (181), Expect = 4e-13
Identities = 90/452 (19%), Positives = 200/452 (44%), Gaps = 58/452 (12%)
Query: 37 SFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQ 96
S + + FK++ ++ Q D L + V E +K K L++ + E++ L+
Sbjct: 1493 SLEHLETFKRENKNLQEEISDLTEQLGEGGKNVH-----ELEKVRKQLEVEKLELQSALE 1547
Query: 97 ERGA----QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT------ 146
E A ++ +I + E +++A + L EK +++++ +T
Sbjct: 1548 EAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAET 1607
Query: 147 ---NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRSL 202
NE+L+ K G+ L M+++ +M KQ + ++ L+ TQ L
Sbjct: 1608 RSRNEVLRVKKKMEGD--------LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1659
Query: 203 EESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLK 262
+++ L+ + +E+ ++E E+L +E+ + E+ ++ ++ + L
Sbjct: 1660 DDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLH 1719
Query: 263 EKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNE 312
+N +++ K+ +E ++ L +VE+ +C+ E++ + + + + ++ +
Sbjct: 1720 SQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSA 1779
Query: 313 NLNAEMQNLKQ-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ--------- 358
+L +N++Q + L++ E+ L+ + Q+ L + +EL L
Sbjct: 1780 HLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESV 1839
Query: 359 KLCSFQEEMVKEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELK 414
K E +KE EE K+ L D +DKLQ K + +R ++ EE+A + + +
Sbjct: 1840 KGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFR 1899
Query: 415 LLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 446
++ +L EAE E++ A +Q L + D
Sbjct: 1900 KVQHEL--DEAE-ERADIAESQVNKLRAKSRD 1928
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 121 bits (303), Expect = 3e-27
Identities = 136/679 (20%), Positives = 306/679 (45%), Gaps = 60/679 (8%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRI 105
Q+ K + V++ ++VK++ K Q + + L E++VLLQ +G + +
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKR 1247
Query: 106 QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGN-QKNLR 164
+ +E +L++++ + N R +T L+ L+ +EL LL S++ K+
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQ---VELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 165 ILSLEL---MKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK 221
L +L +L + + + K + +E + + LEE + LE ++ ++
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 222 EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 281
+ D K + E + + C + E+ K + + E L ++++E ++ LE+
Sbjct: 1365 QVADMKKKME------DSVGCL-ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR 1417
Query: 282 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE----QQEREKLQQ 337
L ++++DL V +++ ++ + ++ + L AE + + K+ E + E + +
Sbjct: 1418 LQQELDDLLVDLD-HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKET 1476
Query: 338 KELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK----LQQKEE 393
K L + L++ E + L + F+ EM ++ ++++ +++ EL+K L+Q+ E
Sbjct: 1477 KALSLARALEEAMEQKAELERLNKQFRTEM-EDLMSSKDDVGKSVHELEKSKRALEQQVE 1535
Query: 394 QAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLE 453
+ + +++LE+E ++ + LE L+ +A+ E+ + + +EK +V+ +
Sbjct: 1536 EMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS---EEKKKQLVRQVR 1592
Query: 454 DVTAQFE---SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 510
++ A+ E +++ + + L+++ L+ A KN ++ Q+ ++ ++ +R
Sbjct: 1593 EMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMR 1652
Query: 511 MLLD---------LQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 561
L D Q K K+ + E + LQ+ + K+Q + R +L DE
Sbjct: 1653 ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Query: 562 KAEK-----------ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVE-----KQ 605
+ K E A+L EE+ + + E + ++ K LQ+D +
Sbjct: 1713 SSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH 1772
Query: 606 ALLNEHGAAQ-EQLNK-IRDSYAKLLGHQNLKQKIKHV---VKLKDENSQLKSEVSKLRC 660
A NE+ Q E+ NK ++ ++ G K K K+ QL +E + +
Sbjct: 1773 AQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQA 1832
Query: 661 QLAKKKQSETKLQEELNKV 679
+ +++E KL++ L +V
Sbjct: 1833 ACKQVRRTEKKLKDVLLQV 1851
Score = 118 bits (295), Expect = 2e-26
Identities = 159/752 (21%), Positives = 321/752 (42%), Gaps = 122/752 (16%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQK---NDKDLKILEKEIRV--L 94
+SQ ++ + ++ L + + A + + + K+ + +D + ++ E+E R L
Sbjct: 875 QSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL 934
Query: 95 LQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTN 147
E+ + IQ+LE +LE+ E+ EK + A LE++ I +L +
Sbjct: 935 QAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEK 994
Query: 148 ELLKSKFSE-NGNQKNLRILSLELMKLRNKRE---TKMRGMMAKQEGMEMKLQVTQRSLE 203
+LL+ + +E N S L KL+NK E T + + ++E +L+ T+R LE
Sbjct: 995 KLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLE 1054
Query: 204 -----------ESQGKIAQLEGKLVSIEKE--------------------KIDE-KSETE 231
E Q +IA+L+ +L E+E KI E +S+
Sbjct: 1055 GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQIS 1114
Query: 232 KLLEYIEEISCASDQVEKYKLDIAQLEENLK------------------EKNDEILSLKQ 273
+L E +E + ++ EK K D+ + E LK ++ E+ LK+
Sbjct: 1115 ELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKK 1174
Query: 274 SLEENIVILSKQVEDLNVK-------------------------CQLLEKEKEDHVNR-- 306
+LEE Q++++ K Q LE E+ + N
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234
Query: 307 -------NREH-NENLNAEMQNLKQKFILEQQEREKLQQK--ELQID-----SLLQQEKE 351
+ EH + + A++Q L+ KF ++ R +L K +LQ++ LL Q
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDS 1294
Query: 352 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSR-- 409
SS L + + + ++ + L +EE +Q L KL+Q E++ +QLEEE +++
Sbjct: 1295 KSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHN 1354
Query: 410 -AEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQEKYDSMVQSLEDVTAQF---ESY 462
+++ L ++ + ++E S A + LQ+ + + Q E+ A + E
Sbjct: 1355 LEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414
Query: 463 KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 522
K E++DL ++ ++ A K + + ++ + +Y + ++ K
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 523 ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 582
ET+ + + L++ + + +L++ + FR ++ED K + + EL +
Sbjct: 1475 ETKALSLARA-LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 583 YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 642
EE+ + + + +L A E K L A + Q RD + Q+ ++K + V
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--RDLQGR--DEQSEEKKKQLVR 1589
Query: 643 KLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 674
++++ ++L+ E + +A +K+ E L++
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Score = 95.5 bits (236), Expect = 2e-19
Identities = 109/547 (19%), Positives = 245/547 (44%), Gaps = 49/547 (8%)
Query: 195 LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 254
LQV+++ EE K E +LV + ++++ ++ ++ ++ Q+++
Sbjct: 838 LQVSRQE-EEMMAK----EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 255 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 314
+L +E + + KQ LEE L +VE+ +CQ L+ EK + +
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEK-----------KKM 941
Query: 315 NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 374
+Q L+++ E+ R+KLQ +++ ++ L++ +E L + C ++ KEK L
Sbjct: 942 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC----KLAKEKKLL 997
Query: 375 EEELKQTLDELDKLQQK-------EEQAERLVKQLEEEAK---SRAEELKLLEEKLKGKE 424
E+ + + L + ++K + + E ++ LEE + + +EL+ KL+G
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 425 AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE---SYKALTASEIEDLKLENSSLQ 481
+L A L+ + + L+ A+ E + K + +I +L+ + S LQ
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 482 E--KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 539
E ++ +A +N + Q + L E E ++ L+ S + E++ Q++
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEE---LEALKTELEDTLDSTAAQQELRS---KREQEVNI 1171
Query: 540 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 599
L+ L+++ + Q+++ + + EL E++ + + + L + + +
Sbjct: 1172 LKKTLEEEAKTHEAQIQE---MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228
Query: 600 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 659
E + LL G ++ + K+ +L N ++++ +L D+ ++L+ E+ +
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR--TELADKVTKLQVELDNVT 1286
Query: 660 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLK--EGNTNCYRAPM 717
L++ +KL ++ + L + D + E+++ +L T LK E N +R +
Sbjct: 1287 GLLSQSDSKSSKLTKDFS-ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 718 ECQESWK 724
E +E K
Sbjct: 1346 EEEEEAK 1352
Score = 92.0 bits (227), Expect = 2e-18
Identities = 122/546 (22%), Positives = 251/546 (45%), Gaps = 86/546 (15%)
Query: 184 MMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEK--SETEKLLEYIE--- 238
MMAK+E + +K++ Q + E ++ L+ +L++ EK ++ E+ +ETE E E
Sbjct: 847 MMAKEEEL-VKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQAETELCAEAEELRA 904
Query: 239 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 298
++ ++E+ D+ E +E+ + + K+ +++NI L +Q+E+ Q L+
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL 964
Query: 299 EK-EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL- 356
EK + E + E QN K +E++ L+ + + + L +E+E S SL
Sbjct: 965 EKVTTEAKLKKLEEEQIILEDQNCKL-----AKEKKLLEDRIAEFTTNLTEEEEKSKSLA 1019
Query: 357 -----HQKLCSFQEEMVKEKNLFEEELKQTLDELD----------------------KLQ 389
H+ + + EE ++ + +EL++T +L+ +L
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079
Query: 390 QKEEQAERLVKQLEEEAKSR---AEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQE 443
+KEE+ + + ++EEEA + ++++ LE ++ + +LE A+ +A L E
Sbjct: 1080 KKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGE 1139
Query: 444 KYDSMVQSLEDV---TAQFESYKALTASEI--------EDLKLENSSLQEKAAKAGKNAE 492
+ +++ LED TA + ++ E+ E+ K + +QE K + E
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 493 DVQHQILATE--SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED 550
++ Q+ T+ +N E + L+ + E ++ LQ D +++ K+ E
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV------LLQGKGDSEHKRKKVE-- 1251
Query: 551 FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE 610
QL++ + + E E EL +++ K L EL N T L + + L +
Sbjct: 1252 --AQLQELQVKFNEGERVRTELADKVTK---LQVELDNVTG----LLSQSDSKSSKLTKD 1302
Query: 611 HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSET 670
A + QL ++ LL +N +QK+ KLK Q++ E + R QL ++++++
Sbjct: 1303 FSALESQLQDTQE----LLQEEN-RQKLSLSTKLK----QVEDEKNSFREQLEEEEEAKH 1353
Query: 671 KLQEEL 676
L++++
Sbjct: 1354 NLEKQI 1359
Score = 67.8 bits (164), Expect = 3e-11
Identities = 109/589 (18%), Positives = 245/589 (41%), Gaps = 66/589 (11%)
Query: 9 KRFNDPSGCAPSPGAYDVKTLEVLKGPVSF--QKSQRFKQQKESKQNLNVDKDTTL-PAS 65
K+ D GC + K + L+G +K + + +++K L + D L
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1430
Query: 66 ARKVKSSESKESQKNDKDLKILEKEIRV-LLQERGAQDRRIQDLETELEKMEARLNAALR 124
++ + ++ QK L EK I +ER + ++ ET+ + L A+
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490
Query: 125 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 184
+K L N ++ +L + + + E +K+ R L ++ +++ + E +
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL--EKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 185 MAKQEG---MEMKLQVTQRSLEES-QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 240
A ++ +E+ LQ + E QG+ Q E K + ++ + ++E E + ++
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE---DERKQR 1605
Query: 241 SCASDQVEKYKLDIAQLEENLKEKN---DEILSLKQSLEENIVILSKQVEDLNV-KCQLL 296
S A +K ++D+ LE ++ N DE + + L+ + ++++D + ++L
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 297 EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL 356
+ KE N + +++ AEM L+++ ++ + + QQ+ ++ E+++S
Sbjct: 1666 AQAKE-----NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD------EIANSS 1714
Query: 357 HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 416
+ + +E K E + Q +EL++ Q E +K+ + +L L
Sbjct: 1715 GKGALALEE-----KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769
Query: 417 EEKLKGKEAELEKSSAAHTQATLLLQE-------KYDSMVQSLEDVTAQFESYKALTASE 469
+ E ++ + + + LQE KY + + +LE AQ E +
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLE-------EQ 1822
Query: 470 IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI 529
+++ E + ++ + K +DV Q+ + ++Y K+ K
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY-------------KDQADKAS 1869
Query: 530 TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK 578
T ++ L+ QL++ EE+ ++ + E E+ T E + +N+
Sbjct: 1870 T-----RLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT-ETADAMNR 1912
Score = 65.9 bits (159), Expect = 1e-10
Identities = 92/429 (21%), Positives = 198/429 (46%), Gaps = 59/429 (13%)
Query: 26 VKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKESQKNDKD 83
V LE K + Q + Q +E + L +D L + + +K+ ++ Q D+
Sbjct: 1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579
Query: 84 LKILEKEI--RVLLQERGAQDRRIQ---------DLETELEKMEARLNAALREKTSLSAN 132
+ +K++ +V E +D R Q LE +L+ +EA +++A + +
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ 1639
Query: 133 NATLEKQLIELTRTNELLKSKFSE-----NGNQKNLRILSLELMKLRNKRETKMRGM-MA 186
L+ Q+ + R + ++ E N+K L+ + E+++L+ + R A
Sbjct: 1640 LRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQA 1699
Query: 187 KQEGMEMKLQVTQRS------LEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 240
+QE E+ ++ S LEE + +LE ++ +E+E +E+ TE + + +++
Sbjct: 1700 QQERDELADEIANSSGKGALALEEKR----RLEARIAQLEEELEEEQGNTELINDRLKK- 1754
Query: 241 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 300
A+ Q+++ D+ LE + +KN+ + +Q LE +Q ++L VK Q +E
Sbjct: 1755 --ANLQIDQINTDL-NLERSHAQKNE---NARQQLE-------RQNKELKVKLQEMEGTV 1801
Query: 301 EDHVNRNREHNENLNAEMQNLKQKFILEQQERE------KLQQKELQIDSLLQQEKELSS 354
+ ++ + L A++ L+++ E +ER+ + +K+L+ D LLQ + E +
Sbjct: 1802 K---SKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLK-DVLLQVDDERRN 1857
Query: 355 SLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELK 414
+ K + + + ++LK+ L+E ++ Q+ + R +++ E+A A+ +
Sbjct: 1858 AEQYK------DQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMN 1911
Query: 415 LLEEKLKGK 423
LK K
Sbjct: 1912 REVSSLKNK 1920
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 119 bits (298), Expect = 1e-26
Identities = 126/549 (22%), Positives = 257/549 (46%), Gaps = 56/549 (10%)
Query: 171 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKID--- 225
MKL K + ++ ++E MK Q T+ L +S+ K +LE KLV++ +EK D
Sbjct: 831 MKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQL 890
Query: 226 -EKSETEKLL---EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 281
++E+E LL E +++ A Q+E ++ + E+ +E N E+ + K+ LE+
Sbjct: 891 QVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 950
Query: 282 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 341
L K ++DL + +EKEK H N+ +NL E+ L + +E++ LQ+ Q
Sbjct: 951 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 342 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 401
LQ E++ +SL++ ++++ ++ E+E K +D L++ + + E +K
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD----LERNKRKLEGDLKL 1062
Query: 402 LEEEAKSRAEELKLLEEKLKGKEAE-LEKSSAAHTQATLLLQ-----EKYDSMVQSLEDV 455
+E + + L+E+LK K+ E + S + TL LQ ++ + ++ LE+
Sbjct: 1063 AQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE 1122
Query: 456 TAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 515
+ +A T + D E L E+ +AG QI + E++++ DL
Sbjct: 1123 IEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST---QIELNKKREAEFLKLRRDL 1179
Query: 516 QTKSALKETEIKEITVSFLQKITDLQNQ----------LKQQEEDFRKQLEDEEG----- 560
+ + E + + + +L Q L++++ +F+ +++D
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239
Query: 561 --RKAEKENTTAELTEEINKWRLLYEELYNK-----TKPFQLQLDAFEVEKQALLNEHGA 613
KA E L +++++ R EE+ T+ +LQ +A E+ +Q L E +
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ--LEEKES 1297
Query: 614 AQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSEVSKLRCQLAKKKQSE 669
QL++ + ++ + + LK++++ K K+ + + + LR Q ++++ +
Sbjct: 1298 IVSQLSRSKQAFTQQT--EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Query: 670 TKLQEELNK 678
+LQ L+K
Sbjct: 1356 AELQRALSK 1364
Score = 110 bits (276), Expect = 4e-24
Identities = 158/717 (22%), Positives = 320/717 (44%), Gaps = 83/717 (11%)
Query: 42 QRFKQQKESKQN---LNVDKDTTLPASARKVKSSESKESQKNDKDLKILE---KEIRVLL 95
QR KQ+ E +++ L +D ++ S K K++ K + + L +EI+ L
Sbjct: 1212 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL 1271
Query: 96 QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 147
E Q R+Q +L +LE+ E+ ++ R K + + L++QL E +
Sbjct: 1272 SELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA 1331
Query: 148 ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 192
+LL+ ++ E Q+ L + E+ + R K ET + +E E
Sbjct: 1332 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD--AIQRTEELEE 1389
Query: 193 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 252
K ++ QR L++S+ ++ + K S+EK K + E E L+ +E + + ++K +
Sbjct: 1390 AKKKLAQR-LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQR 1448
Query: 253 DIAQLEENLKEKNDEILS-LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 311
+ ++ K K +E + L+ SL+E S+ + K + +E D + + N
Sbjct: 1449 NFDKVLAEWKTKCEESQAELEASLKE-----SRSLSTELFKLKNAYEEALDQLETVKREN 1503
Query: 312 ENLNAEMQNLKQ------KFILE-QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ 364
+NL E+ +L + K I E ++ R++++ ++ I L++ + K+ Q
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Query: 365 EEMVKEKNLFEEELKQTLDELDKLQQKEEQA-ERLVKQLEEEAKSRAEELKLLEEKLKGK 423
E+ + K+ + ++ + +E+++L++ ++ E + L+ E +SR E ++L ++K++G
Sbjct: 1564 LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL-KKKMEGD 1622
Query: 424 EAELE-KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 482
E+E + S A+ QA L+ S+ L+D + AL E DLK + + ++
Sbjct: 1623 LNEIEIQLSHANRQAAETLKH-LRSVQGQLKDTQLHLDD--ALRGQE--DLKEQLAIVER 1677
Query: 483 KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN 542
+A E+++ + TE + + + LLD + L T+ + + + TDL
Sbjct: 1678 RANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLM- 1736
Query: 543 QLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTKPFQL 595
QL+ + ED + + E + + A + EE+ K + + L K Q
Sbjct: 1737 QLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1796
Query: 596 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-----------NLKQKIKHVVKL 644
+LD E E+ AL Q+ +IR+ +L G Q ++++K +
Sbjct: 1797 RLD--EAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQ 1854
Query: 645 KDENS----QLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKE 697
+E+ +L+ V KL+ ++ K+ + E+ N H + HE +E
Sbjct: 1855 SEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQAN-----AHLTKFRKAQHELEE 1906
Score = 104 bits (259), Expect = 3e-22
Identities = 132/691 (19%), Positives = 306/691 (44%), Gaps = 74/691 (10%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEI----RVLLQERGAQD 102
Q ES+ L+ ++ A+ ++ KE + +D + + E+ R L E
Sbjct: 893 QAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 952
Query: 103 RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKN 162
+ I DLE L K+E +A + +L+ + L++ + +LTR + L + +Q+
Sbjct: 953 KDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL-----QEAHQQA 1007
Query: 163 LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE 222
L L E K+ + +TK + + + E +E L+ ++ + + +LEG L ++
Sbjct: 1008 LDDLQAEEDKVNSLNKTKSK-LEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQES 1066
Query: 223 KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE---NI 279
+D +++ ++L ++++K + QL+ ++++ L ++ ++E I
Sbjct: 1067 ILDLENDKQQL----------DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARI 1116
Query: 280 VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL---------NAEMQNLKQ-KFI-LE 328
L +++E EK++ D+ E +E L E+ ++ +F+ L
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176
Query: 329 QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ---EEMVKEKNLFEEELKQTLDEL 385
+ E Q E + +L ++ + + L +++ + Q +++ KEK+ F+ E+ +
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236
Query: 386 DKLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 442
+ + + + E++ + LE+ EA+ + EE++ +L +++ L+ + + + L+
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG---ELSRQLE 1293
Query: 443 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 502
EK +S+V L F ++E+ ++L + + + ++ Q +
Sbjct: 1294 EK-ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQ 1352
Query: 503 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 562
E R L ++ A T+ + + +++ + + +L Q+ +D +Q+E +
Sbjct: 1353 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC 1412
Query: 563 AEKENT-------TAELTEEINKWRLLYEELYNKTKPF-------QLQLDAFEVEKQALL 608
A E T +L ++ + L L K + F + + + + E +A L
Sbjct: 1413 ASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL 1472
Query: 609 NEHGAAQEQLNKIRDSYAKLLG--------HQNLKQKIKHVVKLKDENSQLKSEVSKLRC 660
E + +L K++++Y + L ++NL+Q+I + + EN + E+ K R
Sbjct: 1473 KESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRK 1532
Query: 661 QLAKKK--------QSETKLQEELNKVLGIK 683
Q+ +K ++E L+ E K+L I+
Sbjct: 1533 QIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Score = 104 bits (259), Expect = 3e-22
Identities = 164/773 (21%), Positives = 324/773 (41%), Gaps = 105/773 (13%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDL 84
D+ LE+ V +K + K + L+ D T+ R+ K+ + Q D DL
Sbjct: 954 DIDDLELTLAKVEKEKHATENKVKNLTEELS-GLDETIAKLTREKKALQEAHQQALD-DL 1011
Query: 85 KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAAL-REKTSLSANNATLEKQLIEL 143
+ E ++ L + + +++++DLE+ LE+ E +L L R K L + ++ +++L
Sbjct: 1012 QAEEDKVNSLNKTKSKLEQQVEDLESSLEQ-EKKLRVDLERNKRKLEGDLKLAQESILDL 1070
Query: 144 TRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLE 203
+ L + + E +L++K E + + Q+ K++ Q +E
Sbjct: 1071 ENDKQQLDERLKKK---------DFEYCQLQSKVEDEQTLGLQFQK----KIKELQARIE 1117
Query: 204 ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS-CASDQVEKYKLDIAQ------ 256
E + +I EK++ D E E+L E +EE S Q+E K A+
Sbjct: 1118 ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR 1177
Query: 257 -LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK--------------- 300
LEE + + +L++ +++ L +Q+++L Q LEKEK
Sbjct: 1178 DLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSME 1237
Query: 301 ----------------EDHVNRNREHNENLNAEMQNLK-QKFILEQQERE---KLQQKEL 340
ED ++ R NE + + L QK L+ + E +L++KE
Sbjct: 1238 SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE- 1296
Query: 341 QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVK 400
I S L + K+ + ++L EE K KN L+ + + D L+++ E+ +
Sbjct: 1297 SIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1356
Query: 401 QL------------------EEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 442
+L E +A R EEL+ ++KL + + E+ A L+
Sbjct: 1357 ELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLE 1416
Query: 443 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 502
+ + +ED+ E +L A+ + + + L E K ++ +++ + +
Sbjct: 1417 KTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESR 1476
Query: 503 SSNQEYVRMLLDLQTKSALKETE-IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 561
S + E + L + AL + E +K + Q+I DL Q+ + + E E+ R
Sbjct: 1477 SLSTELFK--LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIH---ELEKSR 1531
Query: 562 K-AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK 620
K E E +L E + L +EE K ++QL+ +V K + + E++ +
Sbjct: 1532 KQIELEKADIQLALEEAEAALEHEE----AKILRIQLELTQV-KSEIDRKIAEKDEEIEQ 1586
Query: 621 IRDSYAKLLGHQNLKQKIKHVVKLKDENSQLK----SEVSKLRCQLAKKKQSETKLQEEL 676
++ +Y + + + ++ + V+ ++E +LK +++++ QL+ + + + L
Sbjct: 1587 LKRNYQRTV--ETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHL 1644
Query: 677 NKVLG-IK----HFDPSKAFHHESKENFAL---KTPLKEGNTNCYRAPMECQE 721
V G +K H D + + KE A+ + L + RA +E E
Sbjct: 1645 RSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE 1697
Score = 74.3 bits (181), Expect = 4e-13
Identities = 105/505 (20%), Positives = 218/505 (43%), Gaps = 66/505 (13%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKESQKND---KDLKILEKEIRVLLQERGAQD 102
++ +++ ++ + +L K+K++ + + + ++ K LE+EI L ++
Sbjct: 1462 EESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENG 1521
Query: 103 RRIQDLETELEKME---ARLNAALRE-KTSLSANNATLEKQLIELTRTNELLKSKFSENG 158
+ I +LE +++E A + AL E + +L A + + +ELT+ + K +E
Sbjct: 1522 KTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKD 1581
Query: 159 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 218
+ +E +K RN + T E M+ L RS E+ ++EG L
Sbjct: 1582 EE-------IEQLK-RNYQRTV--------ETMQSALDAEVRSRNEAIRLKKKMEGDLNE 1625
Query: 219 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 278
IE + + + L+++ + + + D + +E+LKE+ L++ +E
Sbjct: 1626 IEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ----LAI---VERR 1678
Query: 279 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 338
+L +VE+L + E+ ++ L ++ +L+ ER +Q
Sbjct: 1679 ANLLQAEVEELRATLEQTERARK-------------------LAEQELLDSNER--VQLL 1717
Query: 339 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL-------DELDKLQQK 391
Q SL+ +K+L + L Q L S E+ ++ EE+ K+ + +EL K Q
Sbjct: 1718 HTQNTSLIHTKKKLETDLMQ-LQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1776
Query: 392 EEQAERLVKQLEEEAKSRAEELKLLEE-KLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 450
ER+ K LE+ K L E+ LKG + +++K + L+ + +
Sbjct: 1777 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTE 1836
Query: 451 SLEDVTAQFESYKALTASEIED----LKLEN--SSLQEKAAKAGKNAEDVQHQILATESS 504
S++ + K LT ED L+L++ LQ K + AE+ Q A +
Sbjct: 1837 SVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTK 1896
Query: 505 NQEYVRMLLDLQTKSALKETEIKEI 529
++ L + + ++ + E+++ ++
Sbjct: 1897 FRKAQHELEEAEERADIAESQVNKL 1921
Score = 61.2 bits (147), Expect = 3e-09
Identities = 85/443 (19%), Positives = 185/443 (41%), Gaps = 75/443 (16%)
Query: 51 KQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGA----QDRRIQ 106
++N N++++ E +K+ K +++ + +I++ L+E A ++ +I
Sbjct: 1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKIL 1560
Query: 107 DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRIL 166
++ EL ++++ ++ + EK + +E+ RT E ++S +N
Sbjct: 1561 RIQLELTQVKSEIDRKIAEK------DEEIEQLKRNYQRTVETMQSALDAEVRSRN---- 1610
Query: 167 SLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ--------------L 212
E ++L+ K E + + + + T + L QG++ L
Sbjct: 1611 --EAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDL 1668
Query: 213 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 272
+ +L +E+ ++E E+L +E+ A E+ LD + + L +N ++ K
Sbjct: 1669 KEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTK 1728
Query: 273 QSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNLK 322
+ LE +++ L +VED + + E++ + + + + ++ + +L +NL+
Sbjct: 1729 KKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE 1788
Query: 323 Q-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMV 368
Q + L++ E+ L+ + QI L + +EL L K E V
Sbjct: 1789 QTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRV 1848
Query: 369 KEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEE-----------------EAK 407
KE EE ++ + D +DKLQ K + +R ++ +E EA+
Sbjct: 1849 KELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAE 1908
Query: 408 SRAEELKLLEEKLKGKEAELEKS 430
RA+ + KL+ K + S
Sbjct: 1909 ERADIAESQVNKLRAKTRDFTSS 1931
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 118 bits (295), Expect = 2e-26
Identities = 167/745 (22%), Positives = 325/745 (43%), Gaps = 116/745 (15%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQER 98
QK++ F Q E+++N + + +T + ++ +K + N + I E+ RV +
Sbjct: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ---IQEELSRVTKLKE 1913
Query: 99 GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG 158
A++ + DLE L A LN ++ +A ++ +L+E N LK SE
Sbjct: 1914 TAEEEK-DDLEERLMNQLAELNGSIGNYCQ-DVTDAQIKNELLESEMKN--LKKCVSELE 1969
Query: 159 NQKNLRILSLELMKLRNKRETKMRGMMA-------KQEGMEMKLQVTQRSLEESQGKIAQ 211
+K +L+K + K E+++R K+ G + + Q L+E Q ++ Q
Sbjct: 1970 EEKQ------QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQ 2023
Query: 212 LEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL 271
L+ + + EKI T K LE+++ S +E K ++AQ E+ K+ E+ S
Sbjct: 2024 LQKDCIRYQ-EKISALERTVKALEFVQTES--QKDLEITKENLAQAVEHRKKAQAELASF 2080
Query: 272 KQSLEENIVILSKQVEDLNVKCQL-LEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 330
K L++ ++ + D N+K + L+ KE ++ ++ +E+L ++ ++K + E++
Sbjct: 2081 KVLLDDTQSEAARVLAD-NLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK 2139
Query: 331 E---------REKLQQKE----LQI-----DSLLQQEKELSSSLHQKLCSFQEEMVKEKN 372
REK+ +E +Q+ D +QQ +E S +L +F + M +
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSM----S 2195
Query: 373 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK--- 429
+++ + +DE K ++K A ++ EEE + + + +L+++L+ +E+
Sbjct: 2196 SLQDDRDRVIDEAKKWERKFSDA---IQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKI 2252
Query: 430 ------------SSAAHTQATL------LLQEKYDSMVQSLEDVTAQFESYK---ALTAS 468
S A T+ L LQ + ++ LE+ + S + A S
Sbjct: 2253 NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLES 2312
Query: 469 EIEDLKLENSSLQ---EKAAKAGKNAEDVQHQILAT-ESSNQEYVRMLLDLQTKSAL--- 521
E++ LK + + L EK + N E + Q A ++S Y ++ DLQ L
Sbjct: 2313 ELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSR 2372
Query: 522 --KETEIKEITVSFL--------------------QKITDLQNQLKQQEEDFRKQLEDEE 559
+E +KE + L ++I +L+N L Q+EE+ LE+E
Sbjct: 2373 LHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE-NIVLEEEN 2431
Query: 560 GRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 619
+ +K N E + I K E + K QLD+F +L N+
Sbjct: 2432 KKAVDKTNQLMETLKTIKK-----ENIQQKA-----QLDSFVKSMSSLQNDRDRIVGDYQ 2481
Query: 620 KIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 677
++ + + ++ Q +++ KLK+E L+S + L + AK + +E+LN
Sbjct: 2482 QLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLN 2541
Query: 678 KVLGIKHFDPSKAFHHESKENFALK 702
+V+ IK + + ++N L+
Sbjct: 2542 QVITIKDSQQKQLLEVQLQQNKELE 2566
Score = 115 bits (288), Expect = 1e-25
Identities = 180/784 (22%), Positives = 327/784 (41%), Gaps = 133/784 (16%)
Query: 48 KESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQD 107
K + + L DK+ L +KSS+ ES + + K L+KE +LLQ ++
Sbjct: 1573 KLALEGLTEDKEK-LVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQS-------YEN 1624
Query: 108 LETELEKMEARLNAALREKTSL-------SANNATLEKQLIELTRTNELLKSKFSENGNQ 160
+ E E+++ + A +EK L AN EKQL E + E +K K +
Sbjct: 1625 VSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKS 1684
Query: 161 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVT---QRSLEESQGKIAQLEGKLV 217
K +IL LE R + E G AK E ME L + LE + + L K
Sbjct: 1685 KQQKILELEEENDRLRAEVHPAGDTAK-ECMETLLSSNASMKEELERVKMEYETLSKKFQ 1743
Query: 218 SIEKEKIDEKSETEKLLEYIE---EISCASDQVEKYKLDIAQLEENLK------EKNDEI 268
S+ EK E + L IE + EK+ EE + E+ D +
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSL 1803
Query: 269 -LSLKQSLEENIVILS--------------------KQVEDLNVKCQLLEKEKEDHVNRN 307
+S + + E++ +Q++ L + LE+EK+ +N
Sbjct: 1804 SMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ----KN 1859
Query: 308 REHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQ-EKELSSSLHQKLCSFQEE 366
+E ++ L E L + + E + LQ++ +++ L QQ ++ELS ++ +E
Sbjct: 1860 KEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELS-----RVTKLKET 1914
Query: 367 MVKEKNLFEEELKQTLDEL------------------DKLQQKEEQAERLVKQLEEEAKS 408
+EK+ EE L L EL + L+ + + ++ V +LEEE +
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 409 RAEELKLLE--------EKLKGKEAEL-EKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF 459
+E +E EK++G + E KS A Q LL+EK + Q +D
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE--LLKEKQQEVKQLQKDCIRYQ 2032
Query: 460 ESYKAL--TASEIEDLKLENSS----LQEKAAKAGKNAEDVQHQI----LATESSNQEYV 509
E AL T +E ++ E+ +E A+A ++ + Q ++ + + + E
Sbjct: 2033 EKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAA 2092
Query: 510 RMLLD-LQTKSALKETEIKEITVSFLQKITDLQNQLKQQEE-------DFRKQLEDEEGR 561
R+L D L+ K L+ + + + QK DL+ +L+Q EE + +++L+
Sbjct: 2093 RVLADNLKLKKELQSNK-ESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRRE 2151
Query: 562 KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKI 621
K E T E+ +NK ++L QL AF +L ++ ++ K
Sbjct: 2152 KVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKW 2211
Query: 622 RDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAK----------KKQSE 669
++ + + ++ K + LKD+ Q+ + +L+ +++ K Q+E
Sbjct: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271
Query: 670 TKLQEEL-------NKVLGIKHFDPSKAFHHESKENFA-----LKTPLKEGNTNCYRAPM 717
+LQ+++ NK L + + ++ +H S+ A LK+ LK+ T+ +
Sbjct: 2272 VQLQQKVCDTLQGENKEL-LSQLEETRHLYHSSQNELAKLESELKS-LKDQLTDLSNSLE 2329
Query: 718 ECQE 721
+C+E
Sbjct: 2330 KCKE 2333
Score = 110 bits (274), Expect = 6e-24
Identities = 153/649 (23%), Positives = 282/649 (43%), Gaps = 68/649 (10%)
Query: 70 KSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSL 129
+S E Q K L+ E + LL + + EL K+E+ L + + T L
Sbjct: 2265 ESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDL 2324
Query: 130 SANNATLEKQ---LIELTRTNE--LLKSKFSENGNQKNL---RILSLELMKLRNKRETKM 181
S + ++Q L + R E + SKFS + +L R L+ L + N +E K+
Sbjct: 2325 SNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKI 2384
Query: 182 RGMMA-KQEGMEMKL----QVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY 236
+++ K+E +++ + Q + ++E + ++Q E + + +E+E +T +L+E
Sbjct: 2385 ISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMET 2444
Query: 237 IEEISCASDQVEKYKLD-IAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQL 295
++ I + Q +K +LD + +L+ D I+ Q LEE + + + + L +
Sbjct: 2445 LKTIKKENIQ-QKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAA 2503
Query: 296 LEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL------QQKELQIDSLLQQE 349
+ ++ + R H ++LN+E L + I +++ ++ QQK+L ++ LQQ
Sbjct: 2504 ENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL-LEVQLQQN 2562
Query: 350 KELS---SSLHQKLCSFQ---EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLE 403
KEL + L +KL + E++ + N +EE + E++ L+ Q R V L+
Sbjct: 2563 KELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQ 2622
Query: 404 EEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 463
EE L L +LK KE E+ + SA + + + LE+ +
Sbjct: 2623 EEG-----TLGLYHAQLKVKEEEVHRLSALFSSS--------QKRIAELEEELVCVQKEA 2669
Query: 464 ALTASEIED-LKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 522
A EIED LK E L A E + ++ E R L++++ K +
Sbjct: 2670 AKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERV-------AELARDLVEMEQKLLMV 2722
Query: 523 ETEIKEITV---SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE-NTTAELTEE--I 576
E K +T SF + ++ LQN E+ DE RK + A+L E+ +
Sbjct: 2723 TKENKGLTAQIQSFGRSMSSLQNSRDHANEEL-----DELKRKYDASLKELAQLKEQGLL 2777
Query: 577 NKWR--LLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNL 634
N+ R LL E ++ + L E Q LL++ +++ DSY +
Sbjct: 2778 NRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSY------NQV 2831
Query: 635 KQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 683
+ K + L++E L +E+ K R K++S + +V +K
Sbjct: 2832 QSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK 2880
Score = 99.8 bits (247), Expect = 8e-21
Identities = 147/673 (21%), Positives = 291/673 (43%), Gaps = 96/673 (14%)
Query: 36 VSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLK-------ILE 88
+S ++ Q Q KE + T L A ++++ + ++ ++ D + +L
Sbjct: 742 LSEERDQLLSQVKE------LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLT 795
Query: 89 KEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNE 148
++I L E ++D +I+ L+ EL+ ++ + + SL + E +++E
Sbjct: 796 EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVR 855
Query: 149 LLKSKFSENG---NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEES 205
+ SK E +QK L I ++ + L KR+ + +Q E QVT+ S +
Sbjct: 856 HISSKVEELSQALSQKELEITKMDQLLLEKKRDVET----LQQTIEEKDQQVTEISFSMT 911
Query: 206 QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKN 265
+ K+V + +EK E + L E + +S A + ++ + ++ LK+
Sbjct: 912 E--------KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNY 963
Query: 266 DEILSL----KQSLEENIVILSKQVEDLNVKCQ---LLEKEKEDHVNRNREHNENLNAEM 318
DE+ K+ L+ +L K+ E K Q + KE V+R E NL E
Sbjct: 964 DEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 1023
Query: 319 QNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEEL 378
K++ L + ER ++++ + ++ EK ++S Q++ + ++ + EK E EL
Sbjct: 1024 ---KKEIPLSETERGEVEEDK---ENKEYSEKCVTSKC-QEIEIYLKQTISEK---EVEL 1073
Query: 379 KQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQAT 438
+ +L++ EEQ + LVKQ+ + + + ++ LL+ ++ +A ++K ++T A+
Sbjct: 1074 QHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDAS 1133
Query: 439 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 498
DS+ E V T S E K E L+EK K E +Q ++
Sbjct: 1134 -----DGDSVALVKETVVIS----PPCTGSS-EHWKPE---LEEKILALEKEKEQLQKKL 1180
Query: 499 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 558
+S K+ LK+ + KE L+ +LKQQ++D+ + E
Sbjct: 1181 QEALTSR------------KAILKKAQEKE---------RHLREELKQQKDDYNRLQEQF 1219
Query: 559 EGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF-------EVEKQALLNEH 611
+ + E EN + +++ + ++ E + P Q ++ E +A H
Sbjct: 1220 DEQSKENEN----IGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275
Query: 612 GAAQEQLNKIRD------SYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKK 665
+ N D + L G ++ Q + +++ E +L+ +VS +L KK
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335
Query: 666 KQSETKLQEELNK 678
+ +LQE++NK
Sbjct: 1336 SEEVFQLQEQINK 1348
Score = 95.5 bits (236), Expect = 2e-19
Identities = 129/658 (19%), Positives = 282/658 (42%), Gaps = 65/658 (9%)
Query: 73 ESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSAN 132
++KE + K L++ E++ +E G + R Q ++ +L+ AL+E SL
Sbjct: 1446 QAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEE 1505
Query: 133 NATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGME 192
+ + LT++ ++S+ S +K+ + L L+ QE +
Sbjct: 1506 LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALL----------------QEERD 1549
Query: 193 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE-----EISCASDQV 247
+ RSL E+Q + E +++E D+ EKL++ IE +I+ +++
Sbjct: 1550 KLITEMDRSLLENQSLSSSCESLKLALEGLTEDK----EKLVKEIESLKSSKIAESTEWQ 1605
Query: 248 EKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRN 307
EK+K ++ + E L + + + + + ++ + + ++ ++L K + E K++ +
Sbjct: 1606 EKHK-ELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQL 1664
Query: 308 REHNENLNAEMQNLKQKFILEQQER-----EKLQQKELQIDSLLQQEKELSSSLHQKLCS 362
+E + + EM+ +KF +Q++ E+ + ++ KE +L S
Sbjct: 1665 QEAEQEME-EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNAS 1723
Query: 363 FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLE---------EEAKSRAEEL 413
+EE+ + K +E K+ + + E+ + L Q+E E + +
Sbjct: 1724 MKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQT 1783
Query: 414 KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT--ASEIE 471
+ EE + E E+ + E S + V+ F S+ + +I+
Sbjct: 1784 NVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQID 1843
Query: 472 DLKLENSSLQEKAAK---AGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 528
LK + L+E+ K + E+ ++ +L+ S+ ++ML + TK L +I+E
Sbjct: 1844 QLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQE 1903
Query: 529 ITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYN 588
L ++T L+ +++++D ++L ++ AE + +++ ++ E L +
Sbjct: 1904 ----ELSRVTKLKETAEEEKDDLEERLMNQ---LAELNGSIGNYCQDVTDAQIKNELLES 1956
Query: 589 KTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDEN 648
+ K + + E EKQ L+ E + ++ K + K+ G Q H +L++
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRK--EYLEKIQGAQKEPGNKSHAKELQELL 2014
Query: 649 SQLKSEVSKLR--CQLAKKKQSETK--------LQEELNKVLGIKHFDPSKAFHHESK 696
+ + EV +L+ C ++K S + +Q E K L I + ++A H K
Sbjct: 2015 KEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKK 2072
Score = 94.0 bits (232), Expect = 4e-19
Identities = 151/729 (20%), Positives = 317/729 (43%), Gaps = 98/729 (13%)
Query: 45 KQQKESKQNLNVDKD---TTLPASARKVKSSESKESQKNDKDLKIL---EKEIRVLLQE- 97
+QQ+ QN + T L AS + + K K + +L E+ I+V + E
Sbjct: 2343 RQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAEL 2402
Query: 98 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 157
R D+ I++LE L + E N L E+ +K + + + E LK+ EN
Sbjct: 2403 RQQHDKEIKELENLLSQEEEE-NIVLEEEN---------KKAVDKTNQLMETLKTIKKEN 2452
Query: 158 GNQK-NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 216
QK L + L+N R+ + +E + + ++E+ + +L+ ++
Sbjct: 2453 IQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEI 2512
Query: 217 VSIEKEKIDEKSETEKL----LEYIEEIS---CASDQVEKYKLDIAQLEENLKEKNDEIL 269
+ D SE KL ++Y E+++ D +K L++ QL++N KE ++
Sbjct: 2513 RGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV-QLQQN-KELENKYA 2570
Query: 270 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 329
L++ L+E+ + EDL L++EK+D + E+L + L ++ Q
Sbjct: 2571 KLEEKLKES----EEANEDLRRSFNALQEEKQDL----SKEIESLKVSISQLTRQVTALQ 2622
Query: 330 QE--------REKLQQKEL-QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ 380
+E + K++++E+ ++ +L ++ + L ++L Q+E K+ E++LK+
Sbjct: 2623 EEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKK 2682
Query: 381 TLDELDK----LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQ 436
L L ++ + E AE V +L + ++L ++ ++ KG A+++ + +
Sbjct: 2683 ELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSS 2742
Query: 437 ATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV-- 494
LQ D + L+++ ++++ + E+ LK + +E+ A + A +
Sbjct: 2743 ----LQNSRDHANEELDELKRKYDA----SLKELAQLKEQGLLNRERDALLSETAFSMNS 2794
Query: 495 --QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ---LKQQEE 549
++ + E NQ+ + L S+ E ++ SF + + LQN+ L + E
Sbjct: 2795 TEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQ-SFSKAMASLQNERDHLWNELE 2853
Query: 550 DFRKQLEDEEGRKAEKENTTAE-----------------LTEEINKWRLLYEEL---YNK 589
FRK E ++ A+ + AE L +E+ + Y ++ +
Sbjct: 2854 KFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITE 2913
Query: 590 TKPFQLQLD-------AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 642
P + QL AF++ ++ L E+ + Q +L+++R + H+ + K ++++
Sbjct: 2914 LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHER-RMKEQYLM 2972
Query: 643 KLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALK 702
+ D++ QL S L+ + + + S ++ Q KV + P + + +N +
Sbjct: 2973 AISDKDQQL----SHLQNLIRELRSSSSQTQP--LKVQYQRQASPETSASPDGSQNLVYE 3026
Query: 703 TPLKEGNTN 711
T L N
Sbjct: 3027 TELLRTQLN 3035
Score = 90.1 bits (222), Expect = 6e-18
Identities = 140/671 (20%), Positives = 274/671 (40%), Gaps = 67/671 (9%)
Query: 81 DKDLKILEKEIRVLLQERGAQDRRIQD----LETELEKMEARLNAALREKTSLSANNATL 136
+K+ + L+K+++ L R A ++ Q+ L EL++ + N + S N +
Sbjct: 1170 EKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENI 1229
Query: 137 EKQLIELT-RTNELLKSKFSENGNQKNLRIL-SLELMKLRNKRETKMRGMMAKQEGMEMK 194
QL +L + E + K Q++ LE + + + ++ +
Sbjct: 1230 GDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWP 1289
Query: 195 LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEK----SETEKLLEYIEEISCASDQVEKY 250
S + +AQ++ +L IE EK++ + S T +L + EE+ +Q+ K
Sbjct: 1290 SHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQ 1349
Query: 251 KLDIAQLEENLKEKNDEILSLKQSLEENIVILS--KQVEDLNVKCQLLEK---EKEDHVN 305
L+I L+ E SL+Q LE + + ++ + + +L K L+K +KE+ V+
Sbjct: 1350 GLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVS 1409
Query: 306 RNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE 365
A + ++ + I+EQ++ K +L++ + ++ E L +LC ++
Sbjct: 1410 YLSGQLSEKEAALTKIQTE-IIEQEDLIKALHTQLEMQA--KEHDERIKQLQVELCEMKQ 1466
Query: 366 EMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE---EKLKG 422
+ EE+ + ++Q+K + A K+ +E KS EEL L E+L
Sbjct: 1467 K--------PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTK 1518
Query: 423 KEAELEKSSAAHTQAT-------LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 475
A++E +A + LLQE+ D ++ ++ + +S +S E LKL
Sbjct: 1519 SLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL----SSSCESLKL 1574
Query: 476 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK----EITV 531
L E K K E ++ +A + QE + K KE EI E
Sbjct: 1575 ALEGLTEDKEKLVKEIESLKSSKIAESTEWQE--------KHKELQKEYEILLQSYENVS 1626
Query: 532 SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 591
+ ++I + ++Q++++ +L E K E E E +E+ + + E++ K
Sbjct: 1627 NEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK---EKMRKFAK 1683
Query: 592 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 651
Q ++ E E L E A + + ++ + +K+E ++
Sbjct: 1684 SKQQKILELEEENDRLRAEVHPAGDTAKECMETL------------LSSNASMKEELERV 1731
Query: 652 KSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTN 711
K E L + + L EE+ + + SK + E+ E +T + E T
Sbjct: 1732 KMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQ 1791
Query: 712 CYRAPMECQES 722
E Q+S
Sbjct: 1792 SIPGETEEQDS 1802
Score = 87.8 bits (216), Expect = 3e-17
Identities = 124/660 (18%), Positives = 283/660 (42%), Gaps = 73/660 (11%)
Query: 48 KESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQD 107
++ K+ L L + +K ++ KE + +LK + + L ++ Q + ++
Sbjct: 1170 EKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE-ELKQQKDDYNRLQEQFDEQSKENEN 1228
Query: 108 LETELEKMEARLNAALREKTSLS------ANNATLEKQLIELTR---TNELLKSKFSENG 158
+ +L +++ ++ ++ K + ++ LE+ L + T T +L+S +
Sbjct: 1229 IGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDW 1288
Query: 159 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 218
+ +L+ + + +++ + A++ +E+K+ T L + ++ QL+ +
Sbjct: 1289 PSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQ--- 1345
Query: 219 IEKEKIDEKSETEKLLEYIEEISCASDQ--VEKYKLDIAQLEE--NLKEKNDEILSLKQS 274
I K+ ++ E+ K + + E+ S Q +E +L IA LE L+ K DE+ L
Sbjct: 1346 INKQGLE--IESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISK 1403
Query: 275 LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK 334
EE++ LS Q+ + ++ E + + + + L + + ++ Q E +
Sbjct: 1404 KEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCE 1463
Query: 335 LQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQ 394
++QK +I + ++++ L L S ++E +KE +EEL +++L +
Sbjct: 1464 MKQKPEEIGEESRAKQQIQRKLQAALIS-RKEALKENKSLQEELSLARGTIERLTKSLAD 1522
Query: 395 AERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS---SAAHTQATLLLQEKYDSMVQS 451
E V +E + L LL+E+ E+++S + + + + L+ + + +
Sbjct: 1523 VESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTED 1582
Query: 452 LEDVTAQFESYKALTASEI-------EDLKLENSSLQEKAAKAGKNAEDVQHQILATESS 504
E + + ES K+ +E ++L+ E L + AE +QH + A
Sbjct: 1583 KEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQE 1642
Query: 505 NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAE 564
QE L T++ KETE +++ + + ++++ +E RK + ++ + E
Sbjct: 1643 KQELYGKL--RSTEANKKETE---------KQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691
Query: 565 KENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS 624
E L E++ D + + LL+ + + +E+L +++
Sbjct: 1692 LEEENDRLRAEVHP-----------------AGDTAKECMETLLSSNASMKEELERVKME 1734
Query: 625 YAKLLGHQNLKQKIKHVVKLKDENS--------QLKSEVSK-LRCQLAKKKQSETKLQEE 675
Y + L +K + ++ KD S Q++ VSK + +K ++T + EE
Sbjct: 1735 Y------ETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEE 1788
Score = 75.9 bits (185), Expect = 1e-13
Identities = 122/606 (20%), Positives = 250/606 (41%), Gaps = 59/606 (9%)
Query: 26 VKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLK 85
VK EV + F SQ+ + E ++ + V K+ +A+KV E K K+LK
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELE-EELVCVQKE-----AAKKVGEIEDKLK----KELK 2685
Query: 86 ILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTR 145
L + ++ E + R+ +L +L +ME +L +E L+A + + + L
Sbjct: 2686 HLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQN 2745
Query: 146 TNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEES 205
+ + + E + + L+ + K +G++ ++ + L T S+ +
Sbjct: 2746 SRDHANEELDELKRKYD--------ASLKELAQLKEQGLLNRER--DALLSETAFSMNST 2795
Query: 206 QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKN 265
+ E L +EK S+ E+LL ++ + +QV+ + +A L+
Sbjct: 2796 E------ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLW 2849
Query: 266 DEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF 325
+E+ ++S EE + Q + Q L+K N + L E++NL+Q++
Sbjct: 2850 NELEKFRKS-EEGKQRSAAQPSTSPAEVQSLKKAMSSLQN----DRDRLLKELKNLQQQY 2904
Query: 326 ILEQQEREKLQQKELQIDSLLQQEKE---LSSSLHQKLCSFQEEMVK---EKNLFE-EEL 378
+ QE +L + Q+ + K + L Q+ S+Q E+ + EK+ +E E
Sbjct: 2905 LQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHER 2964
Query: 379 KQTLDELDKLQQKEEQAERLVKQLEE--EAKSRAEELKLLEEKLKGKEAELEKSSAAH-T 435
+ L + K++Q L + E + S+ + LK+ ++ E + +
Sbjct: 2965 RMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLV 3024
Query: 436 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAE--- 492
T LL+ + + ++ + + + + + +E+ + L + + +N +
Sbjct: 3025 YETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYG 3084
Query: 493 DVQHQILATESSNQEYVRMLLDL-------QTKSALKETEIKEITVSFLQKITDLQNQL- 544
D+ + E QE L++ Q K+ + E Q ++ Q QL
Sbjct: 3085 DLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLC 3144
Query: 545 --KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEV 602
+Q+ + RK LE+E ++ EN + E+I RL + E + P + +
Sbjct: 3145 NTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR--RLEHSEWDSSRTPI---IGSCGT 3199
Query: 603 EKQALL 608
++QALL
Sbjct: 3200 QEQALL 3205
Score = 72.0 bits (175), Expect = 2e-12
Identities = 158/768 (20%), Positives = 310/768 (40%), Gaps = 133/768 (17%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRR 104
KQQ + K+ +TL A + ++ ++ + +KD + E ++R L ++ Q
Sbjct: 189 KQQLQEKEEFI----STLQAQLSQTQAEQAAQQVVREKDARF-ETQVR-LHEDELLQLVT 242
Query: 105 IQDLETELEKMEARLNAALREKTSLSANNAT----LEKQLIELTRTNELLKSKFSENGNQ 160
D+ETE+++ L L E A L+++L + N++L + + +
Sbjct: 243 QADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAE 302
Query: 161 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKI----------- 209
N LRN ET+ E ME+++ + S Q ++
Sbjct: 303 HNT---------LRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
Query: 210 ---AQLEGKLVSIE-KEKIDEKSETEKLLEYI---EEISCASDQVEKYKLDIAQLEENLK 262
A+LE + ++E K K + + +T +L +E+ A D ++ Q + L+
Sbjct: 354 QAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKD------QNSKLLQ 407
Query: 263 EKNDEILSLKQS---LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA--- 316
+KN++ + Q+ LE+ + SK++ + L + E + +NE A
Sbjct: 408 DKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTE 467
Query: 317 -EMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLH----QKLCSFQEEMVKEK 371
+ +L+++ + + E+ L ++++ L + ++LSS + Q + V E
Sbjct: 468 ENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEI 527
Query: 372 NLFEEELKQTLDE----LDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAE- 426
++ + K++ D L+ Q + + L E K EE+ L+ +L+GK AE
Sbjct: 528 SIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEE 587
Query: 427 -------------LEKSSAAHTQATLLLQE---------KYDSMVQSLEDVTAQFESYKA 464
+E A + + L++ +S + ++E A E +++
Sbjct: 588 ADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTE-HQS 646
Query: 465 LTASEI--EDLKLENSSLQEKAAKAGKNAEDV-----------QHQILATE---SSNQEY 508
T+ EI D +E S ++ K+ D+ + QIL E QE
Sbjct: 647 RTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEI 706
Query: 509 VRMLLDLQTK-----------------------SALKETEIKEIT-VSFLQKITDLQNQL 544
LD + K +AL E + ++ V L +T+L+ Q+
Sbjct: 707 YEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQV 766
Query: 545 KQQEEDFRKQLEDEEGRKAEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQLDAFE 601
KQ E + E E R+ + E+ TA LTE+I+ + + K + Q +LD +
Sbjct: 767 KQLEMNL---AEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQ 823
Query: 602 VEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQ 661
++ + Q QL L G + ++ V +L SQ + E++K+
Sbjct: 824 LQFSEQSTLIRSLQSQLQNKESEV--LEGAERVRHISSKVEELSQALSQKELEITKMDQL 881
Query: 662 LAKKKQSETKLQ---EELNKVLGIKHFDPSKAFHHESKENFALKTPLK 706
L +KK+ LQ EE ++ + F ++ ++E F+L +K
Sbjct: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
Score = 70.5 bits (171), Expect = 5e-12
Identities = 121/569 (21%), Positives = 246/569 (43%), Gaps = 98/569 (17%)
Query: 82 KDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI 141
KD+++ +K+ L +ER A D +I+ L K+ A+
Sbjct: 71 KDVQLQQKD-EALQEERKAADNKIKKL-----KLHAKA---------------------- 102
Query: 142 ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 201
+LT N+ ++ ++ G S E + +K T+ EM+++ +
Sbjct: 103 KLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE----------EMEIEKIKHK 152
Query: 202 LEESQGKIAQLEGKLVSIEKEKIDEKSE--------TEKLLEYIEEISCASDQVEKYKLD 253
L+E + I+ L+ +L + E+ + S ++L E E IS Q+ + + +
Sbjct: 153 LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAE 212
Query: 254 IAQLEENLKEKNDEILSLKQSLEENIVILSKQVE---DLNVKCQLLEKEKEDHVNRNREH 310
A ++ ++EK+ + + E+ ++ L Q + ++ K ++L+++ E EH
Sbjct: 213 QA-AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLE-------EH 264
Query: 311 NENL--NAEMQNLKQKFILEQQER-----EKLQQKELQIDSL---LQQEKELSSSLHQKL 360
E+L A++ +L Q+ + ++R ++LQQ E + ++L ++ E+E S L +K+
Sbjct: 265 EESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM 324
Query: 361 CSFQEEMVKEKNL----FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 416
E V E+ L +EE+ L++ ++ Q + + E LE++ K+ EE
Sbjct: 325 ----ELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380
Query: 417 EEKLKGKEAELEKS-SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 475
L+ EL+ + A Q + LLQ+K + VQS + + Q E + EI L
Sbjct: 381 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI-QQLEDQLQQKSKEISQF-L 438
Query: 476 ENSSLQEKAAKAGKNAEDVQHQ--ILATESSNQEYVRMLLDLQTK------SALKETEIK 527
LQ+ + + DV ++ TE + + +++L+ + S+++ E+K
Sbjct: 439 NRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELK 498
Query: 528 EITVSFLQKITDLQNQLKQQEED------------FRKQLEDEEGRKAEKENTTAELTEE 575
+IT L+ Q + E D ++ EE + ENT ++ +E
Sbjct: 499 AENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKE 558
Query: 576 INKWRLLYEELYNKTKPFQLQLDAFEVEK 604
++ L +E + +LQL E+
Sbjct: 559 LSVLLLEMKEAQEEIAFLKLQLQGKRAEE 587
Score = 70.1 bits (170), Expect = 7e-12
Identities = 83/418 (19%), Positives = 182/418 (43%), Gaps = 24/418 (5%)
Query: 301 EDHVNRNREHNENLNAEMQNL-KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 359
++ V + E L E++++ +QK + QQ+ E LQ++ D+ +++ K + +
Sbjct: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTS 106
Query: 360 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 419
L + EEM + Q+ ++L K + + E +++++ + + + E + L+ +
Sbjct: 107 LNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQ 166
Query: 420 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 479
L +AE S+ + ++++++ + + + AQ +A A++
Sbjct: 167 LTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ--------QV 218
Query: 480 LQEKAAKAGKNA---EDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK 536
++EK A+ ED Q++ E + L LQ K L+E E E V Q
Sbjct: 219 VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRK--LEEHE--ESLVGRAQV 274
Query: 537 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK--WRLLYEELYNKTKPFQ 594
+ LQ +L E+ R Q+ ++ ++ E E+ T T E + ++L E++ + +
Sbjct: 275 VDLLQQELTAAEQ--RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
Query: 595 LQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL--LGHQNLKQKIKHVVKLKDENSQLK 652
L + E LL + A + ++ Y+ L +++K H++ L+ +L+
Sbjct: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQ 392
Query: 653 SEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNT 710
S L+ Q +K Q K ++ + I+ + + F + PL++ T
Sbjct: 393 SACDALKDQNSKLLQD--KNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 117 bits (293), Expect = 4e-26
Identities = 121/546 (22%), Positives = 248/546 (45%), Gaps = 50/546 (9%)
Query: 171 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 228
MKL K + ++ ++E MK + T+ L +++ K +LE K+V++ +EK D +
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 229 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 281
+ + + + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 894 QVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 282 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 341
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+ Q
Sbjct: 954 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 342 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 401
LQ E++ ++L + ++++ + E+E K +D L++ + + E +K
Sbjct: 1010 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMD----LERAKRKLEGDLKL 1065
Query: 402 LEEEAKSRAEELKLLEEKLKGKEAELE--KSSAAHTQAT-LLLQEKYDSMVQSLEDVTAQ 458
+E + + L+EKLK KE E+ +S QA + LQ+K + +E++ +
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125
Query: 459 FESYKALTA---SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 515
E+ +A A + DL E + E+ +AG QI + E+ +M DL
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDL 1182
Query: 516 QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 575
+ + E + + +L Q+ + +++LE E+ + + A E
Sbjct: 1183 EEATLQHEATAATLRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEMKMEIDDLASNMET 1241
Query: 576 INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL------ 629
++K + E++ + ++ E E+Q L+N+ A + +L Y++ L
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301
Query: 630 ------GHQNLKQKIKHVVKLKDENSQLKSEVSK-----------LRCQLAKKKQSETKL 672
G Q Q+I+ + + +E + KS ++ LR Q ++++++ +L
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAEL 1361
Query: 673 QEELNK 678
Q ++K
Sbjct: 1362 QRAMSK 1367
Score = 109 bits (272), Expect = 1e-23
Identities = 133/667 (19%), Positives = 296/667 (44%), Gaps = 84/667 (12%)
Query: 70 KSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRI--QDLETELEKMEARLNAALREKT 127
+S+ E+ K D K+ +KE + + +D + L+ ++++++AR+ E
Sbjct: 1068 ESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIE 1127
Query: 128 SLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAK 187
+ A+ A EKQ +L+R E + + E G + +I ++ KRE + + M
Sbjct: 1128 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI------EMNKKREAEFQKMRRD 1181
Query: 188 QEGMEMKLQVTQRSLEESQG-KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ 246
E ++ + T +L + +A+L ++ ++++ K + E ++ I++++ +
Sbjct: 1182 LEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMET 1241
Query: 247 VEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNR 306
V K K LE+ + D++ +K EE + + DL + L+ E ++ +R
Sbjct: 1242 VSKAK---GNLEKMCRALEDQLSEIKTKEEEQ----QRLINDLTAQRARLQTESGEY-SR 1293
Query: 307 NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL------------------QQ 348
+ + L +++ KQ F + +E ++ ++E++ S L ++
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE 1353
Query: 349 EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD----KLQQKEEQAERLVKQLEE 404
E+E + L + + E+ + + +E + Q +EL+ KL Q+ + AE V+ +
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNA 1413
Query: 405 EAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKA 464
+ S + + L+ +++ ++E+++AA D ++ + + A+++
Sbjct: 1414 KCASLEKTKQRLQNEVEDLMIDVERTNAACA--------ALDKKQRNFDKILAEWKQKCE 1465
Query: 465 LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 524
T +E+E + E+ SL + K E+ Q+ + N+ + + DL + A
Sbjct: 1466 ETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1525
Query: 525 EIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR-----------KAEKENTTAELT 573
I E+ +++ +++L+ E+ LE EEG+ K+E + AE
Sbjct: 1526 RIHELE-KIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD 1584
Query: 574 EEINKWR------------LLYEELYNKTKPFQLQL----DAFEVEKQALLNEHGAAQEQ 617
EEI++ + L E+ ++ +L+ D E+E Q L + + A E
Sbjct: 1585 EEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQ-LNHANRMAAEA 1643
Query: 618 LNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ-------LKSEVSKLRCQLAKKKQSE 669
L R++ A L Q +L ++ LK++ + L++E+ +LR L + ++S
Sbjct: 1644 LRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSR 1703
Query: 670 TKLQEEL 676
++EL
Sbjct: 1704 KIAEQEL 1710
Score = 107 bits (267), Expect = 4e-23
Identities = 143/702 (20%), Positives = 288/702 (41%), Gaps = 82/702 (11%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDL 84
D+ LE+ V +K + K + + D T+ ++ K+ + Q D DL
Sbjct: 957 DIDDLELTLAKVEKEKHATENKVKNLTEEM-AGLDETIAKLTKEKKALQEAHQQTLD-DL 1014
Query: 85 KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELT 144
+ E ++ L + + ++++ DLE LE+ + R K L + ++ +++
Sbjct: 1015 QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIE 1074
Query: 145 RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 204
+ L K K+E +M G+ +K E + Q+ ++E
Sbjct: 1075 NDKQQLDEKL--------------------KKKEFEMSGLQSKIEDEQALGMQLQKKIKE 1114
Query: 205 SQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLEYIEEISCA-SDQVEKYKLDIAQ 256
Q +I +LE ++ EK++ D E E++ E +EE A S Q+E K A+
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1174
Query: 257 -------LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE-------- 301
LEE + +L++ +++ L +Q+++L Q LEKEK
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1234
Query: 302 -----DHVNRNREHNENLNAEMQNLKQKFILEQQEREKL------QQKELQIDS-----L 345
+ V++ + + E + +++ + +++E+++L Q+ LQ +S
Sbjct: 1235 LASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ 1294
Query: 346 LQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEE 405
L ++ L S L + +F +++ + K EEE+K LQ + L +Q EEE
Sbjct: 1295 LDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEE 1354
Query: 406 AKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKAL 465
+++AE + + + K Q T L+E + Q L+D E+ A
Sbjct: 1355 QEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAK 1414
Query: 466 TAS----------EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 515
AS E+EDL ++ A K + + + +E L
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1474
Query: 516 QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 575
Q +S TE+ +I ++ + + L+ LK++ ++ ++++ D + AE EL E+
Sbjct: 1475 QKESRSLSTELFKIKNAYEESLDQLET-LKRENKNLQQEISDLTEQIAEGGKRIHEL-EK 1532
Query: 576 INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNL- 634
I K ++ + Q L+ E + + Q +LN+++ + + ++
Sbjct: 1533 IKK------QVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1586
Query: 635 --KQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 674
+ K H+ ++ S L +E+ + KK+ E L E
Sbjct: 1587 IDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1628
Score = 105 bits (263), Expect = 1e-22
Identities = 136/669 (20%), Positives = 296/669 (44%), Gaps = 77/669 (11%)
Query: 68 KVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKT 127
K+K + + + + ++ K+ R L E + I DLE L K+E +A +
Sbjct: 922 KIKEVTERAEDEEEINAELTAKK-RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980
Query: 128 SLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR----- 182
+L+ A L++ + +LT+ + L + +Q+ L L E K+ + K++
Sbjct: 981 NLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV 1035
Query: 183 ----GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE 238
G + +++ + M L+ +R L E K+AQ + +K+++DEK + ++
Sbjct: 1036 DDLEGSLEQEKKIRMDLERAKRKL-EGDLKLAQESTMDIENDKQQLDEKLKKKEF----- 1089
Query: 239 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 298
E+S ++E + QL++ +KE I L++ +E +K + + L +
Sbjct: 1090 EMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD----LSR 1145
Query: 299 EKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQID----SLLQQEKELSS 354
E E+ R E +A+++ K++ Q+ R L++ LQ + +L ++ + +
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA 1205
Query: 355 SLHQKLCSFQ---EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE---EAKS 408
L +++ + Q +++ KEK+ + E+ ++ + + + E++ + LE+ E K+
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKT 1265
Query: 409 RAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSL----EDVTAQFESYKA 464
+ EE + L L + A L+ S +++ L EK D++V L + T Q E K
Sbjct: 1266 KEEEQQRLINDLTAQRARLQTESGEYSRQ---LDEK-DTLVSQLSRGKQAFTQQIEELKR 1321
Query: 465 LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 524
EI+ S+L + + + ++ Q + + E R + ++ A T
Sbjct: 1322 QLEEEIK----AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRT 1377
Query: 525 EIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYE 584
+ + + +++ + + +L Q+ +D + +E + A E T L E+ + E
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVE 1437
Query: 585 E-------LYNKTKPF-------QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 630
L K + F + + + E +A E + +L KI+++Y + L
Sbjct: 1438 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLD 1497
Query: 631 --------HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK--------QSETKLQE 674
++NL+Q+I + + E + E+ K++ Q+ ++K ++E L+
Sbjct: 1498 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEH 1557
Query: 675 ELNKVLGIK 683
E K+L I+
Sbjct: 1558 EEGKILRIQ 1566
Score = 103 bits (256), Expect = 7e-22
Identities = 145/688 (21%), Positives = 315/688 (45%), Gaps = 77/688 (11%)
Query: 42 QRFKQQKE---SKQNLNVDKDTTLPASARKVKSSESKESQKND---KDLKILEKEIRVLL 95
QR KQ+ E S+ + +D + + K K + K + + ++K E+E + L+
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI 1274
Query: 96 QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 147
+ AQ R+Q + +L++ + ++ R K + + L++QL E +
Sbjct: 1275 NDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALA 1334
Query: 148 ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 192
+LL+ ++ E Q+ + + E+ + R K ET + +E E
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETD--AIQRTEELEE 1392
Query: 193 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 252
K ++ QR L++++ + + K S+EK K ++E E L+ +E + A ++K +
Sbjct: 1393 AKKKLAQR-LQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQR 1451
Query: 253 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 312
+ ++ K+K +E + ++ ++ LS ++ K + +E D + + N+
Sbjct: 1452 NFDKILAEWKQKCEETHAELEASQKESRSLSTEL----FKIKNAYEESLDQLETLKRENK 1507
Query: 313 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 372
NL E+ +L ++ + +L++ + Q++ Q++ EL ++L + S + E K
Sbjct: 1508 NLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKSELQAALEEAEASLEHEEGKILR 1564
Query: 373 LFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEEKL 420
+ + EL Q E+D K+ +K+E+ +++ + L+ E +SR + ++L ++K+
Sbjct: 1565 I-QLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL-KKKM 1622
Query: 421 KG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS 478
+G E E++ + A A L Y + L+D + AL + E DLK + +
Sbjct: 1623 EGDLNEMEIQLNHANRMAAEAL--RNYRNTQAILKDTQLHLDD--ALRSQE--DLKEQLA 1676
Query: 479 SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 538
++ +A E+++ + TE S + + LLD + L T+ + + + T
Sbjct: 1677 MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET 1736
Query: 539 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTK 591
D+ +Q++ + ED ++ + E + + A + EE+ K + + L K
Sbjct: 1737 DI-SQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1795
Query: 592 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 651
Q +LD E E+ AL ++Q+ K+ +L G +QK ++V +K
Sbjct: 1796 DLQHRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQK-RNVEAVKGLRKH- 1847
Query: 652 KSEVSKLRCQLAKKKQSETKLQEELNKV 679
+ +V +L Q + +++ +LQ+ ++K+
Sbjct: 1848 ERKVKELTYQTEEDRKNILRLQDLVDKL 1875
Score = 74.3 bits (181), Expect = 4e-13
Identities = 94/435 (21%), Positives = 193/435 (44%), Gaps = 55/435 (12%)
Query: 22 GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKESQK 79
G + LE +K V +KS+ +E++ +L ++ L +VKS ++ +
Sbjct: 1523 GGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1582
Query: 80 NDKDLKILEKE-IRVLLQERGAQDRRIQD----------LETELEKMEARLN-------A 121
D+++ +++ IR++ + D I+ +E +L +ME +LN
Sbjct: 1583 KDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1642
Query: 122 ALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TK 180
ALR + A + L + R+ E LK + + + NL L E+ +LR E T+
Sbjct: 1643 ALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTE 1700
Query: 181 MRGMMAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 228
+A+QE ++ +V T++ LE I+Q++G++ I +E ++
Sbjct: 1701 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQIQGEMEDIIQEA---RN 1754
Query: 229 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SK 284
EK + I + + +++++K + A LE K + L+ L+E + K
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 1814
Query: 285 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 344
Q++ L + + LE E E RN E + L + +K+ +++R+ + + + +D
Sbjct: 1815 QIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDK 1874
Query: 345 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 404
L + K EE ++ N+ + ++ EL++ +++ + AE V +L
Sbjct: 1875 LQAKVKSYKRQ--------AEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKL-- 1924
Query: 405 EAKSRAEELKLLEEK 419
KSR K++ E+
Sbjct: 1925 RVKSREVHTKIISEE 1939
Score = 61.2 bits (147), Expect = 3e-09
Identities = 105/497 (21%), Positives = 209/497 (42%), Gaps = 74/497 (14%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKND---KDLKILEKEIRVLL 95
QK + + E+ Q + +L K+K++ + + + ++ K L++EI L
Sbjct: 1462 QKCEETHAELEASQK----ESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1517
Query: 96 QERGAQDRRIQDLET---ELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNELLK 151
++ +RI +LE ++E+ ++ L AAL E + SL + + +EL + +
Sbjct: 1518 EQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1577
Query: 152 SKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ 211
K +E + ++ MK + R E M+ L RS ++ +
Sbjct: 1578 RKIAEKDEE-------IDQMKRNHIRIV---------ESMQSTLDAEIRSRNDAIRLKKK 1621
Query: 212 LEGKLVSIE----------KEKIDEKSETEKLLEYIE-EISCASDQVEKYKLDIAQLEEN 260
+EG L +E E + T+ +L+ + + A E K +A +E
Sbjct: 1622 MEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERR 1681
Query: 261 LKEKNDEILSLKQSLEE---NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN-- 315
EI L+ +LE+ + I +++ D + + QLL + +N ++ +++
Sbjct: 1682 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI 1741
Query: 316 -AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 374
EM+++ Q+ +++ +K + L++E++ S+ L E M K
Sbjct: 1742 QGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL--------ERMKKNLEQT 1793
Query: 375 EEELKQTLDELDKL---------QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 425
++L+ LDE ++L Q+ E + L ++E E K E +K L K + K
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGL-RKHERKVK 1852
Query: 426 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS----LQ 481
EL + + L LQ+ D + A+ +SYK A E E+ N S +Q
Sbjct: 1853 ELTYQTEEDRKNILRLQDLVDKL-------QAKVKSYKR-QAEEAEEQSNVNLSKFRRIQ 1904
Query: 482 EKAAKAGKNAEDVQHQI 498
+ +A + A+ + Q+
Sbjct: 1905 HELEEAEERADIAESQV 1921
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 117 bits (292), Expect = 5e-26
Identities = 133/551 (24%), Positives = 259/551 (47%), Gaps = 60/551 (10%)
Query: 171 MKLRNKRETKMRGMMAKQEGMEMKLQVTQ--RSLEESQGKIAQLEGKLVSIEKEKIDEKS 228
MKL K + ++ ++E MK + T+ +LE+S+ + +LE K+VS+ +EK D +
Sbjct: 830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889
Query: 229 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND----------EILSLKQSLEEN 278
+ + + + + DQ+ K K+ QLE +KE N+ E+ + K+ LE+
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 279 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 338
L + ++DL + +EKEK N+ + NL EM L + +E++ LQ+
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVK----NLTEEMAGLDEIIAKLTKEKKALQEA 1002
Query: 339 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 398
Q LQ E++ ++L + ++++ + E+E K +D L++ + + E
Sbjct: 1003 HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD----LERAKRKLEGD 1058
Query: 399 VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQEKYDSMVQSLEDV 455
+K +E + + L+E+LK K+ EL +A L LQ+K + +E++
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 456 TAQFESYKALTASEIE----DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRM 511
+ E+ + A ++E DL E + E+ +AG A V QI + E+ +M
Sbjct: 1119 EEELEAERTARA-KVEKLRSDLSRELEEISERLEEAG-GATSV--QIEMNKKREAEFQKM 1174
Query: 512 LLDLQ--------TKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEG 560
DL+ T +AL++ + ++I +LQ +L++++ +F+ +L+D
Sbjct: 1175 RRDLEEATLQHEATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233
Query: 561 R-------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL---LNE 610
KA E L +++N+ R EE Q + E L L+E
Sbjct: 1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293
Query: 611 HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK-QSE 669
A QL + + +Y + L ++LK++++ VK K+ + + ++ C L +++ + E
Sbjct: 1294 KEALISQLTRGKLTYTQQL--EDLKRQLEEEVKAKNALAH-ALQSARHDCDLLREQYEEE 1350
Query: 670 TKLQEELNKVL 680
T+ + EL +VL
Sbjct: 1351 TEAKAELQRVL 1361
Score = 109 bits (273), Expect = 8e-24
Identities = 148/699 (21%), Positives = 296/699 (42%), Gaps = 107/699 (15%)
Query: 88 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL-TRT 146
EKE+ + +E ++ E +++E ++ + L+EK L + L + R
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 147 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLE--- 203
++L+K+K K +M + +E M +L +R LE
Sbjct: 906 DQLIKNKIQLEAKVK------------------EMNERLEDEEEMNAELTAKKRKLEDEC 947
Query: 204 -ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLK 262
E + I LE L +EKEK +++ + L EE++ + + K + L+E +
Sbjct: 948 SELKRDIDDLELTLAKVEKEKHATENKVKNL---TEEMAGLDEIIAKLTKEKKALQEAHQ 1004
Query: 263 EKNDEILSLK---QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQ 319
+ D++ + + +L + V L +QV+DL + +K + D R+ +L +
Sbjct: 1005 QALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQE 1064
Query: 320 NLKQKFILEQQEREKLQQKELQIDSL---LQQEKELSSSLHQKLCSFQEEMVKEKNLFEE 376
++ +QQ E+L++K+ ++++L ++ E+ L S L +KL Q + + EE
Sbjct: 1065 SIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEE----LEE 1120
Query: 377 ELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAE-------LEK 429
EL+ K+++ R ++++ E + + E K +EAE LE+
Sbjct: 1121 ELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1180
Query: 430 SSAAHTQATLLLQEKY-DSM------VQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 482
++ H L++K+ DS+ + +L+ V + E K+ E++D+ + +
Sbjct: 1181 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIK 1240
Query: 483 KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEIT------------ 530
A K ++ Q+ S +E R + DL ++ A +TE E++
Sbjct: 1241 AKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQ 1300
Query: 531 -----VSFLQKITDLQNQLKQQEED-----------------FRKQLEDEEGRKAEKENT 568
+++ Q++ DL+ QL+++ + R+Q E+E KAE +
Sbjct: 1301 LTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRV 1360
Query: 569 TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL 628
++ E+ +WR YE T Q + + E K+ L A+E + + + L
Sbjct: 1361 LSKANSEVAQWRTKYE-----TDAIQ-RTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414
Query: 629 LGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLA---KKKQSETKLQEELNKVLGIKHF 685
+K KH +L++E L +V + A KK+++ K+ E + K+
Sbjct: 1415 -------EKTKH--RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ----KYE 1461
Query: 686 DPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 724
+ KE +L T L + N Y +E E++K
Sbjct: 1462 ESQSELESSQKEARSLSTELFK-LKNAYEESLEHLETFK 1499
Score = 107 bits (266), Expect = 5e-23
Identities = 156/722 (21%), Positives = 299/722 (41%), Gaps = 101/722 (13%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERG 99
K Q + KE + L +++ +A+K K + E + +D+ LE + + +E+
Sbjct: 912 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLED--ECSELKRDIDDLELTLAKVEKEKH 969
Query: 100 AQDRRIQDLETELEKMEARLNAALREKTSLS-ANNATLEKQLIELTRTNELLKSKFS--- 155
A + ++++L E+ ++ + +EK +L A+ L+ E + N L K+K
Sbjct: 970 ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ 1029
Query: 156 -------------------ENGNQK---NLRILSLELMKLRN----------KRETKMRG 183
E +K +L++ +M L N K++ ++
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089
Query: 184 MMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLEY 236
+ A+ E + Q+ L+E Q +I +LE +L +EK + D E E++ E
Sbjct: 1090 LNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1149
Query: 237 IEEISCASD-QVEKYKLDIAQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVED 288
+EE A+ Q+E K A+ ++ ++ + L +L++ +++ L +Q+++
Sbjct: 1150 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1209
Query: 289 LNVKCQLLEKEKE------DHVNRNREHNENLNAEMQNLKQKFILEQQ------------ 330
L Q LEKEK D V N E A ++ + + LE Q
Sbjct: 1210 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRT--LEDQMNEHRSKAEETQ 1267
Query: 331 --------EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 382
+R KLQ + ++ L +++ L S L + ++ +++ K EEE+K
Sbjct: 1268 RSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKN 1327
Query: 383 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 442
LQ + L +Q EEE +++AE ++L + K Q T L+
Sbjct: 1328 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1387
Query: 443 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 502
E + Q L++ E+ A +S L+ LQ + + E A +
Sbjct: 1388 EAKKKLAQRLQEAEEAVEAVNAKCSS----LEKTKHRLQNEIEDLMVDVERSNAAAAALD 1443
Query: 503 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 562
+ + ++L + + K ++E++ S ++ L +L + + + + LE E K
Sbjct: 1444 KKQRNFDKILAEWKQKYEESQSELE----SSQKEARSLSTELFKLKNAYEESLEHLETFK 1499
Query: 563 AEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-QL 618
E +N E LTE++ EL K QL+A ++E Q+ L E A+ E +
Sbjct: 1500 RENKNLQEEISDLTEQLGSSGKTIHELEKVRK----QLEAEKMELQSALEEAEASLEHEE 1555
Query: 619 NKIRDSYAKLLGHQNLKQKIKHVVKLKDEN-SQLKSEVSKLRCQLAKKKQSETKLQEELN 677
KI + L +K +I+ + KDE Q K ++ L +ET+ + E
Sbjct: 1556 GKILRAQ---LEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL 1612
Query: 678 KV 679
+V
Sbjct: 1613 RV 1614
Score = 103 bits (257), Expect = 6e-22
Identities = 171/757 (22%), Positives = 299/757 (39%), Gaps = 152/757 (20%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQER 98
QK + Q + + ++ + T A K++S S+E ++ + L+ V ++
Sbjct: 1105 QKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1164
Query: 99 GAQDRRIQDLETELEKMEARLN-----AALREKTSLSANNATLEKQLIELTRTNELLKSK 153
++ Q + +LE EA L AALR+K + S A L +Q+ L R + L+ +
Sbjct: 1165 KKREAEFQKMRRDLE--EATLQHEATAAALRKKHADSV--AELGEQIDNLQRVKQKLEKE 1220
Query: 154 FSE--------NGNQKNLRILSLELMKLRNKRETKMRGMMAKQE----------GMEMKL 195
SE N + + L K+ E +M +K E KL
Sbjct: 1221 KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKL 1280
Query: 196 QV----TQRSLEESQGKIAQL-EGKLVSIE-----KEKIDE------------------- 226
Q R L+E + I+QL GKL + K +++E
Sbjct: 1281 QTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDC 1340
Query: 227 -------KSETEKLLEYIEEISCASDQV----EKYKLDIAQLEENLKEKNDEILSLKQSL 275
+ ETE E +S A+ +V KY+ D Q E L+E ++ Q
Sbjct: 1341 DLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEA 1400
Query: 276 EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE---- 331
EE VE +N KC LEK K H +N + ++ E N + ++Q
Sbjct: 1401 EE-------AVEAVNAKCSSLEKTK--HRLQNEIEDLMVDVERSNAAAAALDKKQRNFDK 1451
Query: 332 -----REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMV-------KEKNLFEE--- 376
++K ++ + +++S ++ + LS+ L + +++E + + KNL EE
Sbjct: 1452 ILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISD 1511
Query: 377 ------ELKQTLDELDKL-QQKEEQAERLVKQLEE-EAKSRAEELKLL------------ 416
+T+ EL+K+ +Q E + L LEE EA EE K+L
Sbjct: 1512 LTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 1571
Query: 417 -EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 475
E KL K+ E+E++ H + LQ D+ +S + K ++ ++++
Sbjct: 1572 IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEAL----RVKKKMEGDLNEMEI 1627
Query: 476 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQ 535
+ S AA+A K + +Q + T+ + VR DL+ A+ E
Sbjct: 1628 QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERR---------- 1677
Query: 536 KITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQL 595
N L+ + E+ R +E E + E E +E + L N+ K
Sbjct: 1678 -----NNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDA 1732
Query: 596 QLDAFEVEKQALLNEHGAAQ--------------EQLNKIRDSYAKL-LGHQNLKQKIKH 640
L + E + + E A+ E+L K +D+ A L +N++Q IK
Sbjct: 1733 DLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKD 1792
Query: 641 VVKLKDENSQ--LKSEVSKLRCQLAKKKQSETKLQEE 675
+ DE Q LK +L+ A+ ++ E +L+ E
Sbjct: 1793 LQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAE 1829
Score = 99.8 bits (247), Expect = 8e-21
Identities = 150/692 (21%), Positives = 308/692 (44%), Gaps = 82/692 (11%)
Query: 30 EVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESK-ESQKNDKDLKILE 88
+++K + +K R E + N + K S + S +K +++ + ++ E
Sbjct: 1237 QIIKAKANLEKMCR---TLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293
Query: 89 KEIRVLLQERG--AQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT 146
KE + RG ++++DL+ +LE+ NA S + L +Q E T
Sbjct: 1294 KEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEA 1353
Query: 147 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQ 206
L Q+ L + E+ + R K ET + +E E K ++ QR L+E++
Sbjct: 1354 KAEL---------QRVLSKANSEVAQWRTKYETD--AIQRTEELEEAKKKLAQR-LQEAE 1401
Query: 207 GKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND 266
+ + K S+EK K ++E E L+ +E + A+ ++K + + ++ K+K +
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1461
Query: 267 EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI 326
E S +S ++ LS ++ K + +E +H+ + N+NL E+ +L ++
Sbjct: 1462 ESQSELESSQKEARSLSTEL----FKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLG 1517
Query: 327 LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK------EKNLFEEELKQ 380
+ +L++ Q+++ ++ EL S+L + S + E K E N + E+++
Sbjct: 1518 SSGKTIHELEKVRKQLEA---EKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIER 1574
Query: 381 TLDELDKLQQKEEQAER--------LVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSA 432
L E D ++ EQA+R L L+ E +SR E L+ +++K++G E+E +
Sbjct: 1575 KLAEKD---EEMEQAKRNHLRVVDSLQTSLDAETRSRNEALR-VKKKMEGDLNEMEIQLS 1630
Query: 433 AHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAE 492
+ Q++ S+ L+D Q + A+ A+ +DLK + ++ + E
Sbjct: 1631 HANRMAAEAQKQVKSLQSLLKDTQIQLDD--AVRAN--DDLKENIAIVERRNNLLQAELE 1686
Query: 493 DVQHQILATESS----NQEYVR-----MLLDLQTKSALKETEIKEITVSFLQ-KITDLQN 542
+++ + TE S QE + LL Q S + + + + +S LQ ++ +
Sbjct: 1687 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1746
Query: 543 QLKQQEEDFRKQLED-----EEGRKAEKENTTAELTEEINKWRLLYEELYNK-------- 589
+ + EE +K + D EE +K +++T+A L ++L ++
Sbjct: 1747 ECRNAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1804
Query: 590 TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENS 649
K + QL E + L NE A Q++ + + G + +++IK + +E+
Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAEQKR------NAESVKGMRKSERRIKELTYQTEEDR 1858
Query: 650 ----QLKSEVSKLRCQLAKKKQSETKLQEELN 677
+L+ V KL+ ++ K+ + +E+ N
Sbjct: 1859 KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAN 1890
Score = 90.5 bits (223), Expect = 5e-18
Identities = 148/749 (19%), Positives = 307/749 (40%), Gaps = 139/749 (18%)
Query: 42 QRFKQQKESKQN---LNVDKDTT-----LPASARKVKSSESKESQKNDKDLKILE--KEI 91
QR KQ+ E +++ L +D T+ + A A K + E Q N+ K E + +
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270
Query: 92 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 147
L +R +L +L++ EA ++ R K + + L++QL E +
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330
Query: 148 ----------ELLKSKFSENGNQKN--LRILSL---ELMKLRNKRETKMRGMMAKQEGME 192
+LL+ ++ E K R+LS E+ + R K ET + +E E
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD--AIQRTEELEE 1388
Query: 193 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 252
K ++ QR L+E++ + + K S+EK K ++E E L+ +E + A+ ++K +
Sbjct: 1389 AKKKLAQR-LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447
Query: 253 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 312
+ ++ K+K +E S +S ++ LS ++ K + +E +H+ + N+
Sbjct: 1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTEL----FKLKNAYEESLEHLETFKRENK 1503
Query: 313 NLNAEMQNLKQ------KFILEQQE-REKLQQKELQIDSLLQQEK--------------- 350
NL E+ +L + K I E ++ R++L+ +++++ S L++ +
Sbjct: 1504 NLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1563
Query: 351 ---ELSSSLHQKLCSFQEEMVKEKN---LFEEELKQTLD------------------ELD 386
++ + + +KL EEM + K + L+ +LD +L+
Sbjct: 1564 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN 1623
Query: 387 KLQQKEEQAERLVKQLEEEAKS-------------------------------------- 408
+++ + A R+ + +++ KS
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683
Query: 409 RAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS 468
EEL+ + E+ + E+ ++ LL + S++ + + A + +
Sbjct: 1684 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ----T 1739
Query: 469 EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 528
E+E+ E + +EKA KA +A + ++ + ++ RM +++ + + E
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 529 ITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYN 588
L+ +L+ + + +LE E+ R AE + I + EE
Sbjct: 1800 AEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRK 1859
Query: 589 KTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDEN 648
Q +D +++ +A + A+EQ N + +K++H + +E
Sbjct: 1860 NLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF----------RKVQHELDEAEER 1909
Query: 649 SQL-KSEVSKLRCQLAKKKQSETK-LQEE 675
+ + +S+V+KLR AK + TK L EE
Sbjct: 1910 ADIAESQVNKLR---AKSRDIGTKGLNEE 1935
Score = 71.2 bits (173), Expect = 3e-12
Identities = 99/484 (20%), Positives = 213/484 (44%), Gaps = 75/484 (15%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSS--ESKESQKNDK-DLKILEKEIRVLL 95
QK + + + ES Q + +L K+K++ ES E + K + K L++EI L
Sbjct: 1458 QKYEESQSELESSQK----EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1513
Query: 96 QERGAQDRRIQDLETELEKMEAR---LNAALRE-KTSLSANNATLEKQLIELTRTNELLK 151
++ G+ + I +LE +++EA L +AL E + SL + + +E + ++
Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1573
Query: 152 SKFSENGNQ----KNLRILSLELMKLRNKRETKMRG----MMAKQEG----MEMKLQVTQ 199
K +E + K + ++ ++ ET+ R + K EG ME++L
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 200 RSLEESQGKIAQLEGKLVSIEKEKIDE---------------------KSETEKLLEYIE 238
R E+Q ++ L+ L + + D ++E E+L +E
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693
Query: 239 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 298
+ + E+ ++ ++ + L +N +++ K+ ++ ++ L +VE+ +C+ E+
Sbjct: 1694 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753
Query: 299 EKE----------DHVNRNREHNENLNAEMQNLKQ-----KFILEQQEREKLQQKELQID 343
+ + + + + ++ + +L +N++Q + L++ E+ L+ + Q+
Sbjct: 1754 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ 1813
Query: 344 SLLQQEKELSSSLHQ---------KLCSFQEEMVKEKNLFEEELKQTL----DELDKLQQ 390
L + +EL + L K E +KE EE ++ L D +DKLQ
Sbjct: 1814 KLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQL 1873
Query: 391 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 450
K + +R ++ EE+A + + + ++ +L EAE E++ A +Q L + D +
Sbjct: 1874 KVKAYKRQAEEAEEQANTNLSKFRKVQHEL--DEAE-ERADIAESQVNKLRAKSRDIGTK 1930
Query: 451 SLED 454
L +
Sbjct: 1931 GLNE 1934
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 117 bits (292), Expect = 5e-26
Identities = 142/609 (23%), Positives = 284/609 (46%), Gaps = 71/609 (11%)
Query: 111 ELEKMEARLNAALREK-TSLSANNATLEK----QLIELTRTNELLKSKFSENGNQKNLRI 165
E+E + A+L ++EK SL A + L+K L+E+ T L+ + +++
Sbjct: 645 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ--------EAEIKV 696
Query: 166 LSLELMKLRNKRETKMRGMMAKQ----EGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK 221
LE+++ + +TK+ Q E + L +++ E + ++ +L +L + EK
Sbjct: 697 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 756
Query: 222 E----KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE 277
+ +I++ +E+ K S + +++ +L + L+ENL E + +K++LE+
Sbjct: 757 QIKHLEIEKNAESSKA-------SSITRELQGRELKLTNLQENLSE----VSQVKETLEK 805
Query: 278 NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN---AEMQNLKQ-------KFIL 327
+ IL ++ + + + +++ ++ VN+ + E N ++++ L++ KF
Sbjct: 806 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 865
Query: 328 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEM-VKEKNLFEEELKQT-LDEL 385
+ + E+L + + ++++ + + ++S +L +E+ +KE+++ E +LK T +E
Sbjct: 866 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 925
Query: 386 DKLQQK--EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS-------SAAHTQ 436
QK E+ + + +E AK EE K LE KL E ++E S A + +
Sbjct: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
Query: 437 ATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA--AKAGKNAEDV 494
AT + K++ ++Q+L+ E E L E L+++A AKA + AED
Sbjct: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
Query: 495 QHQILATESSNQEYVRMLLDLQTKSA--------LKETEIKEITVSFLQKITDLQNQLKQ 546
+ E + L D + +A LKE +K V L K +L Q
Sbjct: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK--NVEELNKSKELLTVENQ 1103
Query: 547 QEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQA 606
+ E+FRK++E + A+K + L EE K L EEL +++ E E+
Sbjct: 1104 KMEEFRKEIETLKQAAAQKSQQLSALQEENVK---LAEEL-GRSRDEVTSHQKLEEERSV 1159
Query: 607 LLNEHGAAQEQLNK-IRDSYAKLLGHQNLKQKIKHVVKLKD-ENSQLKSEVSKLRCQLAK 664
L N+ +++ +K I+D+ + Q ++ KD E +L++EV+ LR + A
Sbjct: 1160 LNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS 1219
Query: 665 KKQSETKLQ 673
K + +Q
Sbjct: 1220 AKSLHSVVQ 1228
Score = 110 bits (276), Expect = 4e-24
Identities = 149/653 (22%), Positives = 261/653 (39%), Gaps = 106/653 (16%)
Query: 26 VKTLEVLKGPVSFQKS--QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKD 83
VK LEVL+ + Q F Q ++ + +D D + RK S E +K +
Sbjct: 696 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD-----ALRKASSEGKSEMKKLRQQ 750
Query: 84 LKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL 143
L+ EK+I+ L E+ A+ + + EL+ E +L + +S TLEK+L
Sbjct: 751 LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL--- 807
Query: 144 TRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLE 203
++LK KF+E S E + ++ + + + K+E M LE
Sbjct: 808 ----QILKEKFAE---------ASEEAVSVQRSMQETVNKLHQKEEQFNM----LSSDLE 850
Query: 204 ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 263
+ + +A +E K ++ + EKL I EI S +L E LKE
Sbjct: 851 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD-NSSQLTKMNDELRLKE 909
Query: 264 KNDEILSLK-QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLK 322
++ E L LK EN L K +ED+ VK E+ +++ ++ E + L ++ +L+
Sbjct: 910 RDVEELQLKLTKANENASFLQKSIEDMTVKA---EQSQQEAAKKHEEEKKELERKLSDLE 966
Query: 323 QKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 382
+K + ++L+ + + S E K + + + K L
Sbjct: 967 KKMETSHNQCQELKARYERATS--------------------ETKTKHEEILQNLQKTLL 1006
Query: 383 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 442
D DKL+ E+ L+++LEE K + +K+ AA T
Sbjct: 1007 DTEDKLKGAREENSGLLQELEELRK------------------QADKAKAAQTA------ 1042
Query: 443 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 502
+ +Q +E +T + K T + +ED K N+ LQ + +N
Sbjct: 1043 ---EDAMQIMEQMTKE----KTETLASLEDTKQTNAKLQNELDTLKEN-----------N 1084
Query: 503 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 562
N E + +L T K E ++ + Q QL +E+ +L +E GR
Sbjct: 1085 LKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE-NVKLAEELGRS 1143
Query: 563 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ-------ALLNEHGAAQ 615
++ + +L EE + E+ + F D + Q ALL E A
Sbjct: 1144 RDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDA-- 1201
Query: 616 EQLNKIRDSYAKLLGHQNLKQKIKHVVK-LKDENSQLKSEVSKLRCQLAKKKQ 667
+L K+R+ L G + + VV+ L+ + +L+ +V L QL + K+
Sbjct: 1202 -ELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKR 1253
Score = 94.7 bits (234), Expect = 3e-19
Identities = 162/746 (21%), Positives = 316/746 (42%), Gaps = 168/746 (22%)
Query: 39 QKSQRFKQQKESKQNLN-----VDKDTTLPASARKVKSSESKESQKNDKDLKILEKEI-- 91
+K + Q +E K+ + V++++ SE + +KDL + +E+
Sbjct: 423 EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAE 482
Query: 92 --RVLLQERGAQD-----RRIQDLETELEKMEARLNAALREKTSLS----ANNATLEKQL 140
R L + A D +Q++ + EK+E RE TSL A T +K++
Sbjct: 483 LRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEI 542
Query: 141 I-------ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEM 193
+L++ NE LKSK E+ N++N +++L KL E
Sbjct: 543 KALYTATEKLSKENESLKSKL-EHANKENSDVIALWKSKL------------------ET 583
Query: 194 KLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLD 253
+ Q+++EE + VS K E +E +L Q+EK +LD
Sbjct: 584 AIASHQQAMEELK----------VSFSKGLGTETAEFAEL----------KTQIEKMRLD 623
Query: 254 IAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNEN 313
ENL+ + D + +K++E L K + KEKE+ + E
Sbjct: 624 YQHEIENLQNQQDSERAAH----------AKEMEALRAKLMKVIKEKENSL-------EA 666
Query: 314 LNAEMQNLKQKFILEQQER-EKLQQKELQIDSLL-------QQEKELSSSLHQKLCSFQE 365
+ +++ + + ++E ++ KLQ+ E+++ L +Q K + + Q + E
Sbjct: 667 IRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT--E 724
Query: 366 EMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 425
E + + + + + E+ KL+Q+ E AE+ +K LE E + + + + +L+G+E
Sbjct: 725 EKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL 784
Query: 426 ELEK-----SSAAHTQATL-----LLQEKYD-----------SMVQSLEDVTAQFESYKA 464
+L S + + TL +L+EK+ SM +++ + + E +
Sbjct: 785 KLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNM 844
Query: 465 LTASEIEDLK----------LENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLD 514
L+ S++E L+ E +E+ KA + E+ +I+ N + + D
Sbjct: 845 LS-SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 903
Query: 515 LQTKSALKETEIKEITV---------SFLQK-ITDLQNQLKQQEEDFRKQLEDEEGRKAE 564
+ LKE +++E+ + SFLQK I D+ + +Q +++ K+ E+E K E
Sbjct: 904 ---ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE---KKE 957
Query: 565 KENTTAELTEEIN-------KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 617
E ++L +++ + + YE ++TK ++ + ++ LL+ +++
Sbjct: 958 LERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEI--LQNLQKTLLD----TEDK 1011
Query: 618 LNKIRDSYAKLLGHQNLKQKIKHVVKLKDENS---------QLKSEVSKLRCQLAKKKQS 668
L R+ + LL Q L++ K K K + Q+ E ++ L KQ+
Sbjct: 1012 LKGAREENSGLL--QELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQT 1069
Query: 669 ETKLQEEL-----NKVLGIKHFDPSK 689
KLQ EL N + ++ + SK
Sbjct: 1070 NAKLQNELDTLKENNLKNVEELNKSK 1095
Score = 93.6 bits (231), Expect = 6e-19
Identities = 153/711 (21%), Positives = 293/711 (41%), Gaps = 75/711 (10%)
Query: 20 SPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSS------- 72
SP A + ++ + VS + S+ + S + TT A K K
Sbjct: 310 SPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLA 369
Query: 73 ----ESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTS 128
E E K + +E+E+ + R D+ + +LE +++++ + AA REK
Sbjct: 370 ERDLERAEVAKATSHVGEIEQELALA---RDGHDQHVLELEAKMDQLRTMVEAADREKVE 426
Query: 129 LSANNATLEKQLIE----LTRTNELLKSKFSENGNQKNLRILSLE---LMKLRNKRETKM 181
L N EK+ +E + K + RI+ LE ++++ E +
Sbjct: 427 L-LNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRR 485
Query: 182 RGMMAKQEG-MEMKLQVTQR--SLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE 238
R K G ++M L + Q SL+E + ++ KE + ET + + I+
Sbjct: 486 RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQ--KEIK 543
Query: 239 EISCASDQVEKYKLDI-AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLE 297
+ A++++ K + ++LE KE +D I K LE I + +E+L V
Sbjct: 544 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 603
Query: 298 KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQI--DSLLQQEKELSSS 355
+ + E + + Q+ + +Q KE++ L++ KE +S
Sbjct: 604 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 663
Query: 356 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAK---SRAEE 412
L + + ++ K ++ E++ TL++L + + K ++ E L + E+ K + +
Sbjct: 664 LE----AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQ 719
Query: 413 LKLLEEKLKGKEAELEKSSAAHTQATLLLQ--EKYDSMVQSLEDVTAQFESYKALTAS-E 469
LK EEKL +A + SS ++ L Q E + ++ LE + ES KA + + E
Sbjct: 720 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE-IEKNAESSKASSITRE 778
Query: 470 IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI 529
++ +L+ ++LQE ++ + E ++ ++ + K E E
Sbjct: 779 LQGRELKLTNLQENLSEVSQVKETLEKELQILKE------------------KFAEASEE 820
Query: 530 TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNK 589
VS + + + N+L Q+EE F D E + + A+ E+ + EE K
Sbjct: 821 AVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER-----EEQLIK 875
Query: 590 TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENS 649
K +L+ D E+ K + G QL K+ D L +++++ + K + S
Sbjct: 876 AKE-KLENDIAEIMKMS-----GDNSSQLTKMNDELR--LKERDVEELQLKLTKANENAS 927
Query: 650 QLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAF---HHESKE 697
L+ + + + + +Q K EE K L K D K H++ +E
Sbjct: 928 FLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 978
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 117 bits (292), Expect = 5e-26
Identities = 142/609 (23%), Positives = 284/609 (46%), Gaps = 71/609 (11%)
Query: 111 ELEKMEARLNAALREK-TSLSANNATLEK----QLIELTRTNELLKSKFSENGNQKNLRI 165
E+E + A+L ++EK SL A + L+K L+E+ T L+ + +++
Sbjct: 680 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ--------EAEIKV 731
Query: 166 LSLELMKLRNKRETKMRGMMAKQ----EGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK 221
LE+++ + +TK+ Q E + L +++ E + ++ +L +L + EK
Sbjct: 732 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 791
Query: 222 E----KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE 277
+ +I++ +E+ K S + +++ +L + L+ENL E + +K++LE+
Sbjct: 792 QIKHLEIEKNAESSKA-------SSITRELQGRELKLTNLQENLSE----VSQVKETLEK 840
Query: 278 NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN---AEMQNLKQ-------KFIL 327
+ IL ++ + + + +++ ++ VN+ + E N ++++ L++ KF
Sbjct: 841 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900
Query: 328 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEM-VKEKNLFEEELKQT-LDEL 385
+ + E+L + + ++++ + + ++S +L +E+ +KE+++ E +LK T +E
Sbjct: 901 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
Query: 386 DKLQQK--EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS-------SAAHTQ 436
QK E+ + + +E AK EE K LE KL E ++E S A + +
Sbjct: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
Query: 437 ATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA--AKAGKNAEDV 494
AT + K++ ++Q+L+ E E L E L+++A AKA + AED
Sbjct: 1021 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1080
Query: 495 QHQILATESSNQEYVRMLLDLQTKSA--------LKETEIKEITVSFLQKITDLQNQLKQ 546
+ E + L D + +A LKE +K V L K +L Q
Sbjct: 1081 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK--NVEELNKSKELLTVENQ 1138
Query: 547 QEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQA 606
+ E+FRK++E + A+K + L EE K L EEL +++ E E+
Sbjct: 1139 KMEEFRKEIETLKQAAAQKSQQLSALQEENVK---LAEEL-GRSRDEVTSHQKLEEERSV 1194
Query: 607 LLNEHGAAQEQLNK-IRDSYAKLLGHQNLKQKIKHVVKLKD-ENSQLKSEVSKLRCQLAK 664
L N+ +++ +K I+D+ + Q ++ KD E +L++EV+ LR + A
Sbjct: 1195 LNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENAS 1254
Query: 665 KKQSETKLQ 673
K + +Q
Sbjct: 1255 AKSLHSVVQ 1263
Score = 110 bits (276), Expect = 4e-24
Identities = 149/653 (22%), Positives = 261/653 (39%), Gaps = 106/653 (16%)
Query: 26 VKTLEVLKGPVSFQKS--QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKD 83
VK LEVL+ + Q F Q ++ + +D D + RK S E +K +
Sbjct: 731 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD-----ALRKASSEGKSEMKKLRQQ 785
Query: 84 LKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL 143
L+ EK+I+ L E+ A+ + + EL+ E +L + +S TLEK+L
Sbjct: 786 LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL--- 842
Query: 144 TRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLE 203
++LK KF+E S E + ++ + + + K+E M LE
Sbjct: 843 ----QILKEKFAE---------ASEEAVSVQRSMQETVNKLHQKEEQFNM----LSSDLE 885
Query: 204 ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 263
+ + +A +E K ++ + EKL I EI S +L E LKE
Sbjct: 886 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD-NSSQLTKMNDELRLKE 944
Query: 264 KNDEILSLK-QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLK 322
++ E L LK EN L K +ED+ VK E+ +++ ++ E + L ++ +L+
Sbjct: 945 RDVEELQLKLTKANENASFLQKSIEDMTVKA---EQSQQEAAKKHEEEKKELERKLSDLE 1001
Query: 323 QKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 382
+K + ++L+ + + S E K + + + K L
Sbjct: 1002 KKMETSHNQCQELKARYERATS--------------------ETKTKHEEILQNLQKTLL 1041
Query: 383 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 442
D DKL+ E+ L+++LEE K + +K+ AA T
Sbjct: 1042 DTEDKLKGAREENSGLLQELEELRK------------------QADKAKAAQTA------ 1077
Query: 443 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 502
+ +Q +E +T + K T + +ED K N+ LQ + +N
Sbjct: 1078 ---EDAMQIMEQMTKE----KTETLASLEDTKQTNAKLQNELDTLKEN-----------N 1119
Query: 503 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 562
N E + +L T K E ++ + Q QL +E+ +L +E GR
Sbjct: 1120 LKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE-NVKLAEELGRS 1178
Query: 563 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQ-------ALLNEHGAAQ 615
++ + +L EE + E+ + F D + Q ALL E A
Sbjct: 1179 RDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDA-- 1236
Query: 616 EQLNKIRDSYAKLLGHQNLKQKIKHVVK-LKDENSQLKSEVSKLRCQLAKKKQ 667
+L K+R+ L G + + VV+ L+ + +L+ +V L QL + K+
Sbjct: 1237 -ELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKR 1288
Score = 97.1 bits (240), Expect = 5e-20
Identities = 168/761 (22%), Positives = 320/761 (42%), Gaps = 168/761 (22%)
Query: 24 YDVKTLEVLKGPVSFQKSQRFKQQKESKQNL-----NVDKDTTLPASARKVKSSESKESQ 78
+ V+ + KG + Q + KE +Q+L DK R SE
Sbjct: 443 FRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIM 502
Query: 79 KNDKDLKILEKEI----RVLLQERGAQD-----RRIQDLETELEKMEARLNAALREKTSL 129
+ +KDL + +E+ R L + A D +Q++ + EK+E RE TSL
Sbjct: 503 ELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSL 562
Query: 130 S----ANNATLEKQLI-------ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE 178
A T +K++ +L++ NE LKSK E+ N++N +++L KL
Sbjct: 563 KEHFGAREETHQKEIKALYTATEKLSKENESLKSKL-EHANKENSDVIALWKSKL----- 616
Query: 179 TKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE 238
E + Q+++EE + VS K E +E +L
Sbjct: 617 -------------ETAIASHQQAMEELK----------VSFSKGLGTETAEFAEL----- 648
Query: 239 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 298
Q+EK +LD ENL+ + D + +K++E L K + K
Sbjct: 649 -----KTQIEKMRLDYQHEIENLQNQQDSERAAH----------AKEMEALRAKLMKVIK 693
Query: 299 EKEDHVNRNREHNENLNAEMQNLKQKFILEQQER-EKLQQKELQIDSLL-------QQEK 350
EKE+ + E + +++ + + ++E ++ KLQ+ E+++ L +Q K
Sbjct: 694 EKENSL-------EAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTK 746
Query: 351 ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRA 410
+ + Q + EE + + + + + E+ KL+Q+ E AE+ +K LE E + +
Sbjct: 747 VIDNFTSQLKAT--EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 804
Query: 411 EELKLLEEKLKGKEAELEK-----SSAAHTQATL-----LLQEKYD-----------SMV 449
+ + +L+G+E +L S + + TL +L+EK+ SM
Sbjct: 805 SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ 864
Query: 450 QSLEDVTAQFESYKALTASEIEDLK----------LENSSLQEKAAKAGKNAEDVQHQIL 499
+++ + + E + L+ S++E L+ E +E+ KA + E+ +I+
Sbjct: 865 ETVNKLHQKEEQFNMLS-SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 923
Query: 500 ATESSNQEYVRMLLDLQTKSALKETEIKEITV---------SFLQK-ITDLQNQLKQQEE 549
N + + D + LKE +++E+ + SFLQK I D+ + +Q ++
Sbjct: 924 KMSGDNSSQLTKMND---ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 980
Query: 550 DFRKQLEDEEGRKAEKENTTAELTEEIN-------KWRLLYEELYNKTKPFQLQLDAFEV 602
+ K+ E+E K E E ++L +++ + + YE ++TK ++ +
Sbjct: 981 EAAKKHEEE---KKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEI--LQN 1035
Query: 603 EKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENS---------QLKS 653
++ LL+ +++L R+ + LL Q L++ K K K + Q+
Sbjct: 1036 LQKTLLD----TEDKLKGAREENSGLL--QELEELRKQADKAKAAQTAEDAMQIMEQMTK 1089
Query: 654 EVSKLRCQLAKKKQSETKLQEEL-----NKVLGIKHFDPSK 689
E ++ L KQ+ KLQ EL N + ++ + SK
Sbjct: 1090 EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSK 1130
Score = 94.4 bits (233), Expect = 3e-19
Identities = 158/737 (21%), Positives = 297/737 (40%), Gaps = 92/737 (12%)
Query: 20 SPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSS------- 72
SP A + ++ + VS + S+ + S + TT A K K
Sbjct: 310 SPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLA 369
Query: 73 ----ESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTS 128
E E K + +E+E+ + R D+ + +LE +++++ + AA REK
Sbjct: 370 ERDLERAEVAKATSHVGEIEQELALA---RDGHDQHVLELEAKMDQLRTMVEAADREKVE 426
Query: 129 LSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELM-KLRNKRETKMRGMMAK 187
L QL E R E L+ + E K LE KL + R ++ +
Sbjct: 427 LL-------NQLEEEKRKVEDLQFRVEEESITKG----DLETQTKLEHARIKELEQSLLF 475
Query: 188 QEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQV 247
++ KL QR LE+++ + +++ +EK+ E +L +E A D
Sbjct: 476 EKTKADKL---QRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVD 532
Query: 248 EKYKL--DIAQLEENLK----EKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 301
L +I+ L+E L+ + EI SLK+ K+++ L + L KE E
Sbjct: 533 MSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENE 592
Query: 302 DHVNR----NREHNENLNAEMQNLKQKFILEQQEREKLQQK-ELQIDSLLQQEKELSSSL 356
++ N+E+++ + L+ QQ E+L+ + + + EL + +
Sbjct: 593 SLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQI 652
Query: 357 HQKLCSFQEEMVKEKNLFEEELKQTLDELDKL--------QQKEEQAERLVKQLEEEAKS 408
+ +Q E+ +N + E E++ L ++KE E + +L++
Sbjct: 653 EKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQ 712
Query: 409 RAEEL-----KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 463
E+ KL E ++K KE E+ ++ + + + S +++ E+ ++ +
Sbjct: 713 HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI---DNFTSQLKATEEKLLDLDALR 769
Query: 464 ALTA---SEIEDLK--LENSSLQEKAAKAGKNAEDVQHQILATESSNQE--YVRMLLDLQ 516
++ SE++ L+ LE + Q K + KNAE + + E +E + +L
Sbjct: 770 KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS 829
Query: 517 TKSALKET-------------EIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKA 563
S +KET E E VS + + + N+L Q+EE F D E +
Sbjct: 830 EVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE 889
Query: 564 EKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRD 623
+ A+ E+ + EE K K +L+ D E+ K + G QL K+ D
Sbjct: 890 NLADMEAKFREKDER-----EEQLIKAKE-KLENDIAEIMKMS-----GDNSSQLTKMND 938
Query: 624 SYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 683
L +++++ + K + S L+ + + + + +Q K EE K L K
Sbjct: 939 ELR--LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK 996
Query: 684 HFDPSKAF---HHESKE 697
D K H++ +E
Sbjct: 997 LSDLEKKMETSHNQCQE 1013
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 116 bits (291), Expect = 6e-26
Identities = 152/642 (23%), Positives = 282/642 (43%), Gaps = 70/642 (10%)
Query: 73 ESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSAN 132
E++ QK +LKI ++I L QE +R + L+ L+ + L L SL
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK-NLTFQLE---SLEKE 695
Query: 133 NATLEKQLIELTRTNELLKS----------KFSENGNQKNLRILSLELMKLRNKRETKMR 182
N+ L+++ +EL R E LK + E ++K LEL+K K+ ++
Sbjct: 696 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE 755
Query: 183 GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISC 242
+G++++ Q Q++LE S KI QLE +L +E E +K LE ++ S
Sbjct: 756 ---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM----ENQTLQKNLEELKISSK 808
Query: 243 ASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKED 302
+Q+EK + Q L++ ++ + L + I +E+ NVK LEKE
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE--- 865
Query: 303 HVNRNREHNENLNAEMQNLKQKFI----LEQQEREKLQQKELQIDSLLQQEKELSSSLHQ 358
N+ L+ E+ K+ + LE++ +E +++ + I +L+ ++L S +
Sbjct: 866 --------NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS---E 914
Query: 359 KLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEE-LKLLE 417
KL + ++M + EL++ ++L E+ + K LE + +S ++ L++ E
Sbjct: 915 KLKT--QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKE 972
Query: 418 EKLKGKEAELEKSSAAHTQATLLL---QEKYDSMVQSLEDVTAQFESYKALTASEIEDLK 474
EK+ EA LE+S+ + Q L ++ Y+++ Q +D +S ++ ED K
Sbjct: 973 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-QDEERMVQSSPPISG---EDNK 1028
Query: 475 LENSSLQ--EKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI--- 529
E S + + K +V+ ++ Q L L+T++ + +I +
Sbjct: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088
Query: 530 TVSFLQKITDLQNQ----------LKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKW 579
TVS ++ T LQ Q L Q Q +++ EN + +E
Sbjct: 1089 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1148
Query: 580 RLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIK 639
+ LY+ L + +L + E ++L+++HG + + + L N Q +K
Sbjct: 1149 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN--QLLK 1206
Query: 640 HVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 681
+L+D LK E K+ L + K ET + E K+ G
Sbjct: 1207 QKGQLEDLEKMLKVEQEKM---LLENKNHET-VAAEYKKLCG 1244
Score = 112 bits (281), Expect = 9e-25
Identities = 154/669 (23%), Positives = 298/669 (44%), Gaps = 82/669 (12%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRV--LLQ 96
+K+++ K+ + + ++ + + + S +++ D + EK +RV L
Sbjct: 269 EKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-LREKAVRVDKLES 327
Query: 97 ERGAQDRRIQDLE---TELEKMEARLNAALREKTSLS---ANNATLEKQLIELTRTNELL 150
E R+ D+E +E+++ L KT L +L EL + N L
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387
Query: 151 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV---------TQRS 201
K+K + ++++ + K+ E M MA+++ M+ L + T
Sbjct: 388 KAKLHDMEMERDM-----DRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSEL 442
Query: 202 LEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL 261
E Q + +L S K++ E + L + +EE+ D VE I ++E
Sbjct: 443 SEAPQKSLGHEVNELTSSRLLKLE--MENQSLTKTVEELRTTVDSVEGNASKILKME--- 497
Query: 262 KEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL 321
K ++ LS K + EN ++ KQ CQ L K D + + + + +N
Sbjct: 498 --KENQRLSKKVEILENEIVQEKQSLQ---NCQNLSK---DLMKEKAQLEKTIETLRENS 549
Query: 322 KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 381
+++ + +QE E L Q S L+Q ++S+ K ++ KE + E +K+T
Sbjct: 550 ERQIKILEQENEHLNQTV----SSLRQRSQISAEARVK------DIEKENKILHESIKET 599
Query: 382 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL-- 439
+L K++ ++ Q ++ ++ +E+ + RAEEL+ L+ KE EL + + + T
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLE-KENELLQKKITNLKITCEK 657
Query: 440 --LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV--- 494
L+++ + + + +S+K LT ++E L+ ENS L E+ + +N E +
Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEENLELRRNVESLKCA 716
Query: 495 -----QHQILATE-SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ-LKQQ 547
Q Q+ E S +E ++ L+L K++ K+TE E++ L D++NQ L++
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLEL-LKASFKKTERLEVSYQGL----DIENQRLQKT 771
Query: 548 EEDFRKQLE--DEEGRKAEKENTTAELT-EEINKWRLLYEELYNKTKPFQLQLDAFEVEK 604
E+ K+++ + E + E EN T + EE+ E+L + K + + E +K
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 605 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVS--KLRCQL 662
+ L E+ ++Q +I+D+ L N+K + L+ EN L E+ K C
Sbjct: 832 KQLEKENKRLRQQA-EIKDT---TLEENNVK-----IGNLEKENKTLSKEIGIYKESCVR 882
Query: 663 AKKKQSETK 671
K+ + E K
Sbjct: 883 LKELEKENK 891
Score = 95.5 bits (236), Expect = 2e-19
Identities = 147/683 (21%), Positives = 294/683 (43%), Gaps = 92/683 (13%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDL 84
D + LE L+ V K K + +N ++ + ++ + K++++ +
Sbjct: 700 DEENLE-LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSY 758
Query: 85 KILEKEIRVLLQERGAQDRRIQDLETELEKME----------ARLNAALREKTSLSANNA 134
+ L+ E + L + +++IQ LE+EL+ +E L + + L N
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 135 TLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMK 194
+LE++ +L + + L+ + Q ++ +LE ++ K ++K+ G+ +
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878
Query: 195 LQVTQRSLEESQGKI---AQLEGK-LVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKY 250
V + LE+ ++ A ++ K LV++ ++ + EK +T+++ +E++ + ++EK
Sbjct: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL---THELEKI 935
Query: 251 KLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 310
L+ +L + + +D L+ LE L K +E K LE E+ N +
Sbjct: 936 GLNKERLLHDEQSTDDRYKLLESKLEST---LKKSLEIKEEKIAALEARLEESTN----Y 988
Query: 311 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 370
N+ L E++ +K+ + E L+Q++ +E+ + SS + E
Sbjct: 989 NQQLRQELKTVKKNY-------EALKQRQ-------DEERMVQSS---------PPISGE 1025
Query: 371 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS 430
N +E E ++T EL K++ + + ER L+ E ++ +LK LE + +A++
Sbjct: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI--- 1082
Query: 431 SAAHTQATLLLQEKYDSMV---QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKA 487
A + T+ LQE+ ++ L+ + S ++ L ++ SSL+ +
Sbjct: 1083 -LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1141
Query: 488 GKNAEDVQ---------HQILAT--ESSNQEYVRMLLDLQT-KSALKETEIKEITVSFLQ 535
K ED++ H+ L E EY ++ T KSA K E++ +
Sbjct: 1142 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH------R 1195
Query: 536 KITDLQNQL---KQQEEDFRKQLEDEEGR----KAEKENTTAE---LTEEINKWRLLYEE 585
+ D NQL K Q ED K L+ E+ + E AE L E ++ Y +
Sbjct: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255
Query: 586 LYNKTKPFQLQ-------LDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKI 638
L +T+ Q L+ ++E+ L E +EQ ++ + KL L ++
Sbjct: 1256 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1315
Query: 639 KHVVKLKDENSQLKSEVSKLRCQ 661
K L++EN L ++ L Q
Sbjct: 1316 KG--NLEEENRHLLDQIQTLMLQ 1336
Score = 77.0 bits (188), Expect = 6e-14
Identities = 137/628 (21%), Positives = 264/628 (42%), Gaps = 124/628 (19%)
Query: 138 KQLIELTRTNELL--KSKFSENGNQKNLRILSLEL---MKLRNKRE--TKMRGM-MAKQE 189
+QLI ++ N L+ K+ FSE G ++ ++L L L ++ + K E +++G+ +
Sbjct: 95 QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKA 154
Query: 190 GMEMKLQVTQRSLEE------------SQGKIAQLEGKLVSIEKEKIDEKSE-TEKLLEY 236
+ +Q + E SQ I L + K IDE+ E +E ++E
Sbjct: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214
Query: 237 IEEIS---------------CASDQVEKY-------------KLDIAQLEENLKEKNDEI 268
EE C S +++ K I +L + L+EK +++
Sbjct: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQL 274
Query: 269 LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 328
L KQ LE + E + R ++ N NL ++ ++ + +
Sbjct: 275 LDCKQELE----------------------QMEIELKRLQQENMNLLSDARSAR----MY 308
Query: 329 QQEREKLQQKELQIDSLLQQEKELSSSLH---------QKLCSFQEEMVKEKNLFEEELK 379
+ E + L++K +++D L + LH ++L + +++ K + E++L+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 380 QTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 439
T DKL + E++ +L +L + R + K +EE L + LE + +L
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE-LMEENMTLEMAQKQSMDESL 427
Query: 440 LLQEKYDSMVQSLEDVTAQFES----YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 495
L + + + ++ E A +S LT+S + L++EN SL + + + V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 496 ---HQILATESSNQ-----------EYVRMLLDLQ-----TKSALKETEIKEITVSFLQK 536
+IL E NQ E V+ LQ +K +KE E T+ L++
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 537 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQ 596
++ Q ++ +QE + Q R+ + + A + + + ++L+E + K +
Sbjct: 548 NSERQIKILEQENEHLNQTVSSL-RQRSQISAEARVKDIEKENKILHESI----KETSSK 602
Query: 597 LDAFEVEKQAL------LNEHGAAQEQL-NKIR--DSYAKLLGHQ--NLKQKIKHVVKLK 645
L E EK+ + E G E+L N++ + +LL + NLK + + L+
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 646 DENSQLKSEVSKLRCQLAKKKQSETKLQ 673
ENS+L+ E KL+ L K +L+
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLE 690
Score = 70.9 bits (172), Expect = 4e-12
Identities = 129/583 (22%), Positives = 246/583 (42%), Gaps = 80/583 (13%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSES----KESQKNDKDL-KILEKEIRV 93
Q Q K K++ + L +D + S E +ESQ+ ++L K+ ++ I V
Sbjct: 991 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050
Query: 94 ------LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 147
L E+ A +++ LET+ ++A++ A R+ SL N TL+ Q +L N
Sbjct: 1051 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1110
Query: 148 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 207
L S+ + NQ N ++L ++ L N+ E+ ++ L+ SL +
Sbjct: 1111 STLNSQSTSLMNQ-NAQLL-IQQSSLENENESVIKE--------REDLKSLYDSLIKDHE 1160
Query: 208 KIAQLEGKLVSIEKEKIDE----KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 263
K+ L + S + I + KS + L ++ +Q+ K K + LE+ LK
Sbjct: 1161 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1220
Query: 264 KNDEILSLKQSLEENIVILSKQV----EDLNVKCQLLEKEKE----DH------VNRNRE 309
+ +++L L+ E + K++ + LN L KE E DH +N ++
Sbjct: 1221 EQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1279
Query: 310 HNENLNAEMQNLKQKFILEQQEREKLQ-QKEL--QIDSLLQQEKELSSSLHQKLC----S 362
L AE LK+++ KL Q EL Q+ L++E Q L +
Sbjct: 1280 EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRT 1339
Query: 363 FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 422
E+ ++ K+LF E +Q +D+L++L++++E+ LEEK+
Sbjct: 1340 LLEQNMESKDLFHVEQRQYIDKLNELRRQKEK---------------------LEEKIMD 1378
Query: 423 KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIED----LKLENS 478
+ + S + L K +++S +D+ + + LT + + L+L +
Sbjct: 1379 QYKFYDPSPPRRRGNWITL--KMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1436
Query: 479 SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT----KSALKETEIKEITVSFL 534
Q+ ++ + ED Q L T+ S+ ++ L L+ K +K + ++++ L
Sbjct: 1437 DSQDSSSVGSNSLED--GQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDL 1494
Query: 535 QKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN 577
+ L Q E+ + G++ ++ A T IN
Sbjct: 1495 VQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAIN 1537
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 116 bits (290), Expect = 8e-26
Identities = 137/564 (24%), Positives = 266/564 (47%), Gaps = 86/564 (15%)
Query: 171 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 228
MKL K + ++ ++E MK Q + L +S+ K +LE K+V++ KEK D +
Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 229 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 281
+ + E + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 282 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK--- 338
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 956 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 339 ----------------------ELQIDSL---LQQEKELSSSLHQK-------LCSFQEE 366
E Q+D L L+QEK+L L + L QE
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 367 MV---KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 423
++ EK +E+LK+ E+ LQ K E + L QL+++ K ++ LEE+++ +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 424 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQ 481
A K+ + + L+E + + ++ +AQ E K A E + ++ LE ++LQ
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQ 1190
Query: 482 EKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 538
+A A K+A+ V L + N + V+ L+ + KS +K EI ++ S ++ ++
Sbjct: 1191 HEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLE-KEKSEMK-MEIDDL-ASNVETVS 1245
Query: 539 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 598
+ L++ QL + + ++ E++ +LT + + L ++ F QLD
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR-------LQTESGEFSRQLD 1298
Query: 599 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSE 654
EK+AL++ QL++ + ++ + + + LK++++ +K K+ + + +
Sbjct: 1299 ----EKEALVS-------QLSRGKQAFTQQI--EELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 655 VSKLRCQLAKKKQSETKLQEELNK 678
LR Q ++++S+ +LQ L+K
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK 1369
Score = 106 bits (265), Expect = 7e-23
Identities = 137/660 (20%), Positives = 284/660 (43%), Gaps = 59/660 (8%)
Query: 68 KVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKT 127
K+K + + + + ++ K+ R L E + I DLE L K+E +A +
Sbjct: 924 KIKEVTERAEDEEEINAELTAKK-RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 982
Query: 128 SLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR----- 182
+L+ A L++ + +LT+ + L + +Q+ L L E K+ + K++
Sbjct: 983 NLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV 1037
Query: 183 ----GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE 238
G + +++ + M L+ +R L E K+AQ + EK+++DEK + ++
Sbjct: 1038 DDLEGSLEQEKKLRMDLERAKRKL-EGDLKLAQESIMDIENEKQQLDEKLKKKEF----- 1091
Query: 239 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE---ENIVILSKQVEDLNVKCQL 295
EIS ++E + QL++ +KE I L++ +E + KQ DL+ + +
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 296 LEKEKED---HVNRNREHNENLNAEMQNLKQKF------------ILEQQEREKLQQKEL 340
+ + E+ + E N+ AE Q +++ L ++ + + +
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 341 QIDSL------LQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQ 394
QID+L L++EK L S E + K K E+ + D+L +L+ KEE+
Sbjct: 1212 QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271
Query: 395 AERLVKQLEEEAKSRAEELKLLEEKLKGKEA---ELEKSSAAHTQATLLLQEKYDSMVQS 451
+RL+ L + E +L KEA +L + A TQ L+ + + +++
Sbjct: 1272 QQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKA 1331
Query: 452 LEDVTAQFESYK---ALTASEIEDLKLENSSLQEKAAKAGKNAED--VQHQILATESSNQ 506
+ +S + L + E+ + + LQ +KA +++ A + + +
Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEE 1391
Query: 507 -EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEK 565
E + L + ++A + E + L+K + +L+ + ED +E A
Sbjct: 1392 LEEAKKKLAQRLQAAEEHVEAVNAKCASLEK---TKQRLQNEVEDLMLDVERTNAACAAL 1448
Query: 566 ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 625
+ + + +W+ EE + + + Q + + E + N + + +QL ++
Sbjct: 1449 DKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKREN 1508
Query: 626 AKLLGH-QNLKQKIKHVVKLKDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNKVLGIK 683
L +L ++I K E ++K +V + +C+L A +++E L+ E K+L I+
Sbjct: 1509 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ 1568
Score = 105 bits (261), Expect = 2e-22
Identities = 152/705 (21%), Positives = 314/705 (44%), Gaps = 94/705 (13%)
Query: 42 QRFKQQKE---SKQNLNVDKDTTLPASARKVKSSESKESQKND---KDLKILEKEIRVLL 95
QR KQ+ E S+ + +D + + K K + K + + +LK E+E + L+
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 96 QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 147
+ AQ R+Q + +L++ EA ++ R K + + L++QL E +
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336
Query: 148 ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 192
+LL+ ++ E Q+ L + E+ + R K ET + +E E
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD--AIQRTEELEE 1394
Query: 193 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 252
K ++ QR L+ ++ + + K S+EK K ++E E L+ +E + A ++K +
Sbjct: 1395 AKKKLAQR-LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 253 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 312
+ ++ K+K +E + ++ ++ L ++ K + +E D + + N+
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTEL----FKIKNAYEESLDQLETLKRENK 1509
Query: 313 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 372
NL E+ +L ++ + +L++ + Q++ Q++ EL ++L + S + E K
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKCELQAALEEAEASLEHEEGKILR 1566
Query: 373 LFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEEKL 420
+ + EL Q E+D K+ +K+E+ ++L + L+ E +SR + ++L ++K+
Sbjct: 1567 I-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL-KKKM 1624
Query: 421 KG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS 478
+G E E++ + A A L Y + L+D + AL + E DLK + +
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEAL--RNYRNTQGILKDTQIHLDD--ALRSQE--DLKEQLA 1678
Query: 479 SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 538
++ +A E+++ + TE S + + LLD + L T+ + + + T
Sbjct: 1679 MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET 1738
Query: 539 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTK 591
D+ +Q++ + ED ++ + E + + A + EE+ K + + + K
Sbjct: 1739 DI-SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Query: 592 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK---------IKHVV 642
QL+LD E E+ AL ++Q+ K+ +L G +QK KH
Sbjct: 1798 DLQLRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851
Query: 643 KLKDENSQ----------LKSEVSKLRCQLAKKKQSETKLQEELN 677
++K+ Q L+ V KL+ ++ K+ + +E+ N
Sbjct: 1852 RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896
Score = 104 bits (259), Expect = 3e-22
Identities = 154/701 (21%), Positives = 292/701 (41%), Gaps = 80/701 (11%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDL 84
D+ LE+ V +K + K + + D T+ ++ K+ + Q D DL
Sbjct: 959 DIDDLELTLAKVEKEKHATENKVKNLTEEM-AGLDETIAKLTKEKKALQEAHQQTLD-DL 1016
Query: 85 KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAAL-REKTSLSANNATLEKQLIEL 143
+ E ++ L + + ++++ DLE LE+ E +L L R K L + ++ ++++
Sbjct: 1017 QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ-EKKLRMDLERAKRKLEGDLKLAQESIMDI 1075
Query: 144 TRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLE 203
+ L K L+ E+ L++K E + A ++ K++ Q +E
Sbjct: 1076 ENEKQQLDEK---------LKKKEFEISNLQSKIEDE----QALGIQLQKKIKELQARIE 1122
Query: 204 ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCA-SDQVEKYKLDIAQ------ 256
E + +I EK++ D E E++ E +EE A S Q+E K A+
Sbjct: 1123 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182
Query: 257 -LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE-------------D 302
LEE + +L++ +++ L +Q+++L Q LEKEK +
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242
Query: 303 HVNRNREHNE----NLNAEMQNLKQKFILEQQ-------EREKLQQKELQIDSLLQQEKE 351
V++ + + E L ++ LK K +Q+ +R +LQ + + L +++
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 352 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE 411
L S L + +F +++ + K EEE+K LQ + L +Q EEE +S+AE
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE 1362
Query: 412 ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS--- 468
+ L + K Q T L+E + Q L+ E+ A AS
Sbjct: 1363 LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422
Query: 469 -------EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL 521
E+EDL L+ A K + +ILA E L+ K A
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD-KILAEWKQKCEETHAELEASQKEAR 1481
Query: 522 K-ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWR 580
TE+ +I ++ + + L+ LK++ ++ ++++ D + AE EL
Sbjct: 1482 SLGTELFKIKNAYEESLDQLET-LKRENKNLQQEISDLTEQIAEGGKRIHEL-------- 1532
Query: 581 LLYEELYNKTKPFQLQLDAFEVEKQALL-NEHG---AAQEQLNKIRDSYAKLLGHQNL-- 634
E++ + + + +L A E +A L +E G Q +LN+++ + + ++
Sbjct: 1533 ---EKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1589
Query: 635 -KQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 674
+ K H+ ++ S L +E+ + KK+ E L E
Sbjct: 1590 DQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1630
Score = 102 bits (255), Expect = 1e-21
Identities = 134/664 (20%), Positives = 282/664 (42%), Gaps = 90/664 (13%)
Query: 76 ESQKNDKDLKILEKEIRVLLQERGAQDRRIQ--DLETELEKMEARLNAALREKTSLSANN 133
E++K D K+ +KE + + +D + L+ ++++++AR+ E + A+
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135
Query: 134 ATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEM 193
A EKQ +L+R E + + E G + +I ++ KRE + + M E +
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQI------EMNKKREAEFQKMRRDLEEATL 1189
Query: 194 KLQVTQRSLEESQG--------KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASD 245
+ + T +L + +I L+ +EKEK + K E + L +E +S A
Sbjct: 1190 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG 1249
Query: 246 QVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVN 305
+EK + D++ LK EE + + DL + L+ E + +
Sbjct: 1250 NLEKM----------CRTLEDQLSELKSKEEEQ----QRLINDLTAQRGRLQTESGEF-S 1294
Query: 306 RNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL------------------Q 347
R + E L +++ KQ F + +E ++ ++E++ + L +
Sbjct: 1295 RQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYE 1354
Query: 348 QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAK 407
+E+E + L + L E+ + + +E + Q +EL++ ++K Q + ++ E
Sbjct: 1355 EEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 408 SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTA 467
++ L+ +++L+ + +L A L +K ++ + + A+++ T
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ----RNFDKILAEWKQKCEETH 1470
Query: 468 SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK 527
+E+E + E SL + K E+ Q+ + N+ + + DL + A I
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH 1530
Query: 528 EITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR-----------KAEKENTTAELTEEI 576
E+ +++ + +L+ E+ LE EEG+ K+E + AE EEI
Sbjct: 1531 ELE-KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1589
Query: 577 NKWR------------LLYEELYNKTKPFQLQL----DAFEVEKQALLNEHGAAQEQLNK 620
++ + L E+ ++ +L+ D E+E Q L + + A E L
Sbjct: 1590 DQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQ-LNHANRMAAEALRN 1648
Query: 621 IRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ-------LKSEVSKLRCQLAKKKQSETKL 672
R++ L Q +L ++ LK++ + L++E+ +LR L + ++S
Sbjct: 1649 YRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708
Query: 673 QEEL 676
++EL
Sbjct: 1709 EQEL 1712
Score = 70.1 bits (170), Expect = 7e-12
Identities = 93/435 (21%), Positives = 189/435 (43%), Gaps = 55/435 (12%)
Query: 22 GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKESQK 79
G + LE +K V +K + +E++ +L ++ L +VKS ++ +
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584
Query: 80 NDKDLKILEKE-IRVLLQERGAQDRRIQD----------LETELEKMEARLNAALREKTS 128
D+++ L++ IR++ + D I+ +E +L +ME +LN A R
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644
Query: 129 LSANNATLEK-------QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TK 180
N + L + R+ E LK + + + NL L E+ +LR E T+
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTE 1702
Query: 181 MRGMMAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 228
+A+QE ++ +V T++ LE I+Q++G++ I +E ++
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQMQGEMEDILQEA---RN 1756
Query: 229 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SK 284
EK + I + + +++++K + A LE K + L+ L+E + K
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 285 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 344
Q++ L + + LE E E RN E + L + +K+ +++R+ + + + +D
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876
Query: 345 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 404
L + K EE ++ N + ++ EL++ +++ + AE V +L
Sbjct: 1877 LQAKVKSYKRQ--------AEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL-- 1926
Query: 405 EAKSRAEELKLLEEK 419
KSR K++ E+
Sbjct: 1927 RVKSREVHTKVISEE 1941
Score = 68.6 bits (166), Expect = 2e-11
Identities = 91/424 (21%), Positives = 188/424 (44%), Gaps = 68/424 (16%)
Query: 82 KDLKILEKEIRVLLQERGAQDRRIQDLET---ELEKMEARLNAALRE-KTSLSANNATLE 137
++ K L++EI L ++ +RI +LE ++E+ + L AAL E + SL +
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL 1565
Query: 138 KQLIELTRTNELLKSKFSENGNQ----KNLRILSLELMKLRNKRETKMRG----MMAKQE 189
+ +EL + + K +E + K I +E M+ E + R + K E
Sbjct: 1566 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625
Query: 190 G--MEMKLQV-----------------------TQRSLEESQGKIAQLEGKLVSIEKEKI 224
G EM++Q+ TQ L+++ L+ +L +E+
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRAN 1685
Query: 225 DEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSK 284
++E E+L +E+ + E+ LD ++ + L +N +++ K+ LE +I +
Sbjct: 1686 LLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQG 1745
Query: 285 QVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNLKQ-----KFILEQ 329
++ED+ + + E++ + + + + ++ + +L +N++Q + L++
Sbjct: 1746 EMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDE 1805
Query: 330 QEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMVKEKNLFEEELKQ 380
E+ L+ + QI L + +EL + K E VKE EE ++
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1865
Query: 381 TL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQ 436
+ D +DKLQ K + +R ++ EE++ + + + L+ +L +EAE E++ A +Q
Sbjct: 1866 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL--EEAE-ERADIAESQ 1922
Query: 437 ATLL 440
L
Sbjct: 1923 VNKL 1926
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 116 bits (290), Expect = 8e-26
Identities = 137/564 (24%), Positives = 266/564 (47%), Gaps = 86/564 (15%)
Query: 171 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 228
MKL K + ++ ++E MK Q + L +S+ K +LE K+V++ KEK D +
Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 229 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 281
+ + E + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 282 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK--- 338
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 956 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 339 ----------------------ELQIDSL---LQQEKELSSSLHQK-------LCSFQEE 366
E Q+D L L+QEK+L L + L QE
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 367 MV---KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 423
++ EK +E+LK+ E+ LQ K E + L QL+++ K ++ LEE+++ +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 424 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQ 481
A K+ + + L+E + + ++ +AQ E K A E + ++ LE ++LQ
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQ 1190
Query: 482 EKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 538
+A A K+A+ V L + N + V+ L+ + KS +K EI ++ S ++ ++
Sbjct: 1191 HEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLE-KEKSEMK-MEIDDL-ASNVETVS 1245
Query: 539 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 598
+ L++ QL + + ++ E++ +LT + + L ++ F QLD
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR-------LQTESGEFSRQLD 1298
Query: 599 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSE 654
EK+AL++ QL++ + ++ + + + LK++++ +K K+ + + +
Sbjct: 1299 ----EKEALVS-------QLSRGKQAFTQQI--EELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 655 VSKLRCQLAKKKQSETKLQEELNK 678
LR Q ++++S+ +LQ L+K
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK 1369
Score = 106 bits (265), Expect = 7e-23
Identities = 137/660 (20%), Positives = 284/660 (43%), Gaps = 59/660 (8%)
Query: 68 KVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKT 127
K+K + + + + ++ K+ R L E + I DLE L K+E +A +
Sbjct: 924 KIKEVTERAEDEEEINAELTAKK-RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 982
Query: 128 SLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR----- 182
+L+ A L++ + +LT+ + L + +Q+ L L E K+ + K++
Sbjct: 983 NLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQV 1037
Query: 183 ----GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE 238
G + +++ + M L+ +R L E K+AQ + EK+++DEK + ++
Sbjct: 1038 DDLEGSLEQEKKLRMDLERAKRKL-EGDLKLAQESIMDIENEKQQLDEKLKKKEF----- 1091
Query: 239 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE---ENIVILSKQVEDLNVKCQL 295
EIS ++E + QL++ +KE I L++ +E + KQ DL+ + +
Sbjct: 1092 EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 296 LEKEKED---HVNRNREHNENLNAEMQNLKQKF------------ILEQQEREKLQQKEL 340
+ + E+ + E N+ AE Q +++ L ++ + + +
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 341 QIDSL------LQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQ 394
QID+L L++EK L S E + K K E+ + D+L +L+ KEE+
Sbjct: 1212 QIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEE 1271
Query: 395 AERLVKQLEEEAKSRAEELKLLEEKLKGKEA---ELEKSSAAHTQATLLLQEKYDSMVQS 451
+RL+ L + E +L KEA +L + A TQ L+ + + +++
Sbjct: 1272 QQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKA 1331
Query: 452 LEDVTAQFESYK---ALTASEIEDLKLENSSLQEKAAKAGKNAED--VQHQILATESSNQ 506
+ +S + L + E+ + + LQ +KA +++ A + + +
Sbjct: 1332 KNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEE 1391
Query: 507 -EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEK 565
E + L + ++A + E + L+K + +L+ + ED +E A
Sbjct: 1392 LEEAKKKLAQRLQAAEEHVEAVNAKCASLEK---TKQRLQNEVEDLMLDVERTNAACAAL 1448
Query: 566 ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 625
+ + + +W+ EE + + + Q + + E + N + + +QL ++
Sbjct: 1449 DKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKREN 1508
Query: 626 AKLLGH-QNLKQKIKHVVKLKDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNKVLGIK 683
L +L ++I K E ++K +V + +C+L A +++E L+ E K+L I+
Sbjct: 1509 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQ 1568
Score = 105 bits (261), Expect = 2e-22
Identities = 152/705 (21%), Positives = 314/705 (44%), Gaps = 94/705 (13%)
Query: 42 QRFKQQKE---SKQNLNVDKDTTLPASARKVKSSESKESQKND---KDLKILEKEIRVLL 95
QR KQ+ E S+ + +D + + K K + K + + +LK E+E + L+
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 96 QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 147
+ AQ R+Q + +L++ EA ++ R K + + L++QL E +
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336
Query: 148 ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 192
+LL+ ++ E Q+ L + E+ + R K ET + +E E
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD--AIQRTEELEE 1394
Query: 193 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 252
K ++ QR L+ ++ + + K S+EK K ++E E L+ +E + A ++K +
Sbjct: 1395 AKKKLAQR-LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 253 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 312
+ ++ K+K +E + ++ ++ L ++ K + +E D + + N+
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTEL----FKIKNAYEESLDQLETLKRENK 1509
Query: 313 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 372
NL E+ +L ++ + +L++ + Q++ Q++ EL ++L + S + E K
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKCELQAALEEAEASLEHEEGKILR 1566
Query: 373 LFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEEKL 420
+ + EL Q E+D K+ +K+E+ ++L + L+ E +SR + ++L ++K+
Sbjct: 1567 I-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL-KKKM 1624
Query: 421 KG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS 478
+G E E++ + A A L Y + L+D + AL + E DLK + +
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEAL--RNYRNTQGILKDTQIHLDD--ALRSQE--DLKEQLA 1678
Query: 479 SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 538
++ +A E+++ + TE S + + LLD + L T+ + + + T
Sbjct: 1679 MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET 1738
Query: 539 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTK 591
D+ +Q++ + ED ++ + E + + A + EE+ K + + + K
Sbjct: 1739 DI-SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Query: 592 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK---------IKHVV 642
QL+LD E E+ AL ++Q+ K+ +L G +QK KH
Sbjct: 1798 DLQLRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851
Query: 643 KLKDENSQ----------LKSEVSKLRCQLAKKKQSETKLQEELN 677
++K+ Q L+ V KL+ ++ K+ + +E+ N
Sbjct: 1852 RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896
Score = 104 bits (259), Expect = 3e-22
Identities = 154/701 (21%), Positives = 292/701 (41%), Gaps = 80/701 (11%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDL 84
D+ LE+ V +K + K + + D T+ ++ K+ + Q D DL
Sbjct: 959 DIDDLELTLAKVEKEKHATENKVKNLTEEM-AGLDETIAKLTKEKKALQEAHQQTLD-DL 1016
Query: 85 KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAAL-REKTSLSANNATLEKQLIEL 143
+ E ++ L + + ++++ DLE LE+ E +L L R K L + ++ ++++
Sbjct: 1017 QAEEDKVNTLTKAKIKLEQQVDDLEGSLEQ-EKKLRMDLERAKRKLEGDLKLAQESIMDI 1075
Query: 144 TRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLE 203
+ L K L+ E+ L++K E + A ++ K++ Q +E
Sbjct: 1076 ENEKQQLDEK---------LKKKEFEISNLQSKIEDE----QALGIQLQKKIKELQARIE 1122
Query: 204 ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCA-SDQVEKYKLDIAQ------ 256
E + +I EK++ D E E++ E +EE A S Q+E K A+
Sbjct: 1123 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182
Query: 257 -LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE-------------D 302
LEE + +L++ +++ L +Q+++L Q LEKEK +
Sbjct: 1183 DLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVE 1242
Query: 303 HVNRNREHNE----NLNAEMQNLKQKFILEQQ-------EREKLQQKELQIDSLLQQEKE 351
V++ + + E L ++ LK K +Q+ +R +LQ + + L +++
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 352 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE 411
L S L + +F +++ + K EEE+K LQ + L +Q EEE +S+AE
Sbjct: 1303 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE 1362
Query: 412 ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS--- 468
+ L + K Q T L+E + Q L+ E+ A AS
Sbjct: 1363 LQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK 1422
Query: 469 -------EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL 521
E+EDL L+ A K + +ILA E L+ K A
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFD-KILAEWKQKCEETHAELEASQKEAR 1481
Query: 522 K-ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWR 580
TE+ +I ++ + + L+ LK++ ++ ++++ D + AE EL
Sbjct: 1482 SLGTELFKIKNAYEESLDQLET-LKRENKNLQQEISDLTEQIAEGGKRIHEL-------- 1532
Query: 581 LLYEELYNKTKPFQLQLDAFEVEKQALL-NEHG---AAQEQLNKIRDSYAKLLGHQNL-- 634
E++ + + + +L A E +A L +E G Q +LN+++ + + ++
Sbjct: 1533 ---EKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1589
Query: 635 -KQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 674
+ K H+ ++ S L +E+ + KK+ E L E
Sbjct: 1590 DQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1630
Score = 102 bits (255), Expect = 1e-21
Identities = 134/664 (20%), Positives = 282/664 (42%), Gaps = 90/664 (13%)
Query: 76 ESQKNDKDLKILEKEIRVLLQERGAQDRRIQ--DLETELEKMEARLNAALREKTSLSANN 133
E++K D K+ +KE + + +D + L+ ++++++AR+ E + A+
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135
Query: 134 ATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEM 193
A EKQ +L+R E + + E G + +I ++ KRE + + M E +
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQI------EMNKKREAEFQKMRRDLEEATL 1189
Query: 194 KLQVTQRSLEESQG--------KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASD 245
+ + T +L + +I L+ +EKEK + K E + L +E +S A
Sbjct: 1190 QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKG 1249
Query: 246 QVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVN 305
+EK + D++ LK EE + + DL + L+ E + +
Sbjct: 1250 NLEKM----------CRTLEDQLSELKSKEEEQ----QRLINDLTAQRGRLQTESGEF-S 1294
Query: 306 RNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL------------------Q 347
R + E L +++ KQ F + +E ++ ++E++ + L +
Sbjct: 1295 RQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYE 1354
Query: 348 QEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAK 407
+E+E + L + L E+ + + +E + Q +EL++ ++K Q + ++ E
Sbjct: 1355 EEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 408 SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTA 467
++ L+ +++L+ + +L A L +K ++ + + A+++ T
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ----RNFDKILAEWKQKCEETH 1470
Query: 468 SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK 527
+E+E + E SL + K E+ Q+ + N+ + + DL + A I
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH 1530
Query: 528 EITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR-----------KAEKENTTAELTEEI 576
E+ +++ + +L+ E+ LE EEG+ K+E + AE EEI
Sbjct: 1531 ELE-KIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI 1589
Query: 577 NKWR------------LLYEELYNKTKPFQLQL----DAFEVEKQALLNEHGAAQEQLNK 620
++ + L E+ ++ +L+ D E+E Q L + + A E L
Sbjct: 1590 DQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQ-LNHANRMAAEALRN 1648
Query: 621 IRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ-------LKSEVSKLRCQLAKKKQSETKL 672
R++ L Q +L ++ LK++ + L++E+ +LR L + ++S
Sbjct: 1649 YRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708
Query: 673 QEEL 676
++EL
Sbjct: 1709 EQEL 1712
Score = 70.1 bits (170), Expect = 7e-12
Identities = 93/435 (21%), Positives = 189/435 (43%), Gaps = 55/435 (12%)
Query: 22 GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKESQK 79
G + LE +K V +K + +E++ +L ++ L +VKS ++ +
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584
Query: 80 NDKDLKILEKE-IRVLLQERGAQDRRIQD----------LETELEKMEARLNAALREKTS 128
D+++ L++ IR++ + D I+ +E +L +ME +LN A R
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644
Query: 129 LSANNATLEK-------QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TK 180
N + L + R+ E LK + + + NL L E+ +LR E T+
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTE 1702
Query: 181 MRGMMAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 228
+A+QE ++ +V T++ LE I+Q++G++ I +E ++
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQMQGEMEDILQEA---RN 1756
Query: 229 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SK 284
EK + I + + +++++K + A LE K + L+ L+E + K
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 285 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 344
Q++ L + + LE E E RN E + L + +K+ +++R+ + + + +D
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876
Query: 345 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 404
L + K EE ++ N + ++ EL++ +++ + AE V +L
Sbjct: 1877 LQAKVKSYKRQ--------AEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL-- 1926
Query: 405 EAKSRAEELKLLEEK 419
KSR K++ E+
Sbjct: 1927 RVKSREVHTKVISEE 1941
Score = 68.6 bits (166), Expect = 2e-11
Identities = 91/424 (21%), Positives = 188/424 (44%), Gaps = 68/424 (16%)
Query: 82 KDLKILEKEIRVLLQERGAQDRRIQDLET---ELEKMEARLNAALRE-KTSLSANNATLE 137
++ K L++EI L ++ +RI +LE ++E+ + L AAL E + SL +
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL 1565
Query: 138 KQLIELTRTNELLKSKFSENGNQ----KNLRILSLELMKLRNKRETKMRG----MMAKQE 189
+ +EL + + K +E + K I +E M+ E + R + K E
Sbjct: 1566 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625
Query: 190 G--MEMKLQV-----------------------TQRSLEESQGKIAQLEGKLVSIEKEKI 224
G EM++Q+ TQ L+++ L+ +L +E+
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRAN 1685
Query: 225 DEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSK 284
++E E+L +E+ + E+ LD ++ + L +N +++ K+ LE +I +
Sbjct: 1686 LLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQG 1745
Query: 285 QVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNLKQ-----KFILEQ 329
++ED+ + + E++ + + + + ++ + +L +N++Q + L++
Sbjct: 1746 EMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDE 1805
Query: 330 QEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEMVKEKNLFEEELKQ 380
E+ L+ + QI L + +EL + K E VKE EE ++
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1865
Query: 381 TL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQ 436
+ D +DKLQ K + +R ++ EE++ + + + L+ +L +EAE E++ A +Q
Sbjct: 1866 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL--EEAE-ERADIAESQ 1922
Query: 437 ATLL 440
L
Sbjct: 1923 VNKL 1926
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 115 bits (289), Expect = 1e-25
Identities = 164/706 (23%), Positives = 315/706 (44%), Gaps = 102/706 (14%)
Query: 49 ESKQNLNVDKDT--TLPASARKVKSSESKESQ-KNDKDLKILEKEIRV-----LLQERGA 100
+++ + N DK +L + K++ E Q K++ + K I++ L E G
Sbjct: 413 DNRTSSNADKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGN 472
Query: 101 QDRRIQDLETELEK----MEARLNAALRE-------KTSLSANNATLEKQLIEL---TRT 146
Q R ++ +++EK ++ R+N R+ + ++ +TL+ QL +L ++
Sbjct: 473 QRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQN 532
Query: 147 NELLKSKFSENGNQKN-----LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 201
++L K S+ Q LR S ++LR K T+M +++ E + +LQ R
Sbjct: 533 SQLANEKLSQLQKQLEEANDLLRTESDTAVRLR-KSHTEMSKSISQLESLNRELQERNRI 591
Query: 202 LEESQGKIAQLEGKLVSI-EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEEN 260
LE S+ + + +L +I E E+ D ++E + + I+ ++V+ K ++ ++E
Sbjct: 592 LENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGE 651
Query: 261 LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQN 320
KE D +L+ + + N+ I DLN K + L++ E VN ++ L + Q+
Sbjct: 652 RKEAQD-MLNHSEKEKNNLEI------DLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQS 704
Query: 321 LKQ-----------KFILEQQEREKLQQKELQID---SLLQQEKELSSSLHQKLCSFQEE 366
+++ K E++ REK + + +QI+ S+L + + S + L +E
Sbjct: 705 IEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKER 764
Query: 367 MVKE-KNL-------------FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEE 412
M E KNL + ELK E D L+ E+Q ++ + L E + E
Sbjct: 765 MEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFE 824
Query: 413 LKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIED 472
L L ++ +G E ++ + +A Y + V+ L++ + E +I++
Sbjct: 825 LAQLTKQYRGNEGQM-RELQDQLEAEQYFSTLYKTQVKELKE---EIEEKNRENLKKIQE 880
Query: 473 LKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEI--KEIT 530
L+ E +L + A AE Q LA ++Y + + + ++ EI K+ T
Sbjct: 881 LQNEKETLATQLDLAETKAESEQ---LARGLLEEQYFELTQESKKAASRNRQEITDKDHT 937
Query: 531 VSFLQKIT-----DLQNQLKQQEEDFRKQLEDEEGRKAEKE----NTTAELTEEINKWRL 581
VS L++ D++ ++ EE K + EE K EKE N A + IN R
Sbjct: 938 VSRLEEANSMLTKDIEILRRENEELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERT 997
Query: 582 LYEELYNKTKPFQLQLDAFEVEKQAL--------LNEHGAAQEQLNKIRDSYAKLLGHQN 633
L + NK + D F+++++ E+ Q +LN+ R+ + +++
Sbjct: 998 LKTQAVNKLAEIMNRKD-FKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMV---- 1052
Query: 634 LKQKIKHVVKLKDENSQLKSEV---SKLRCQLAKKKQSETKLQEEL 676
+KH +L D +QL E ++L+ QLA K+ +L+ +L
Sbjct: 1053 ----VKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKL 1094
Score = 48.9 bits (115), Expect = 2e-05
Identities = 49/241 (20%), Positives = 113/241 (46%), Gaps = 9/241 (3%)
Query: 89 KEIRVLLQERGAQD-RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 147
KE++ ++E+ ++ ++IQ+L+ E E + +L+ A + S LE+Q ELT+ +
Sbjct: 861 KELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQES 920
Query: 148 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 207
+ S+ + K+ + LE ++ + + ++E E+ ++ + E
Sbjct: 921 KKAASRNRQEITDKDHTVSRLEEANSMLTKDIE----ILRRENEELTEKMKKAEEEYKLE 976
Query: 208 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASD-QVEKYKLDIAQLEENLKEKND 266
K ++ + EK E++ + + + EI D ++++ K + L + KE
Sbjct: 977 KEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRK 1036
Query: 267 EILSLKQSLEE-NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF 325
L L Q E+ N +++ Q E +++ QL+E+ H N + + ++++ L+ K
Sbjct: 1037 LQLELNQEREKFNQMVVKHQKELNDMQAQLVEECA--HRNELQMQLASKESDIEQLRAKL 1094
Query: 326 I 326
+
Sbjct: 1095 L 1095
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 115 bits (287), Expect = 2e-25
Identities = 138/634 (21%), Positives = 267/634 (42%), Gaps = 70/634 (11%)
Query: 49 ESKQNLNVDKDTTLPASARKVKSSESKESQKNDK-----DLKILEKEIRVLLQERGAQDR 103
E + N K A VK S E+ DK L LE+E + + A ++
Sbjct: 579 ELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQ 638
Query: 104 RIQDLETELEKMEARLNAALREKTSLSAN-------NATLEKQLIELTRTNELLKSKFSE 156
L+ +L + E R A + T L A A L+ L ++ E ++ K SE
Sbjct: 639 ARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSE 698
Query: 157 NGNQKNLRILSLELMKLRNKRETKM--------RGMMAKQEGMEMKLQVTQRSLEESQGK 208
+ +Q+ LE + KR+ ++ ++ ++ +E++LQ +R ++ +
Sbjct: 699 SRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQ 758
Query: 209 IAQLEGKLVSIEKEKIDEKSETE-------KLLEYIEEISCASDQVE------KYKLDIA 255
+ L +E + + + +L I+ ++ A + ++ K +LD
Sbjct: 759 LQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTE 818
Query: 256 QLEENLKEKNDEILSLKQSLEENIVILSKQV----EDLNVKCQLLEKEKEDHVNRNREHN 311
+ + +E++ L Q+ +E L +Q +++N + EKE+ H +
Sbjct: 819 RSQAE-QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKAL 877
Query: 312 ENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEK 371
E+L E L+ + +Q E E +Q Q +E + LC Q E KE+
Sbjct: 878 ESLEREKMELEMRLKEQQTEMEAIQA----------QREEERTQAESALCQMQLETEKER 927
Query: 372 NLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS 431
E L QT EL Q Q ERL + ++ + E +L+ +L+ + EL++++
Sbjct: 928 VSLLETLLQTQKELADASQ---QLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAA 984
Query: 432 AAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKA---G 488
H LQE+ S++Q D+ Q E K+ ++ + +L +QEK +
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYN 1044
Query: 489 KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE 548
+ ++++ + + S E + LL LQ ++++ E+ + +Q+ Q +L Q
Sbjct: 1045 RIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD-MQEAQGEQKELSAQM 1103
Query: 549 EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEEL-------YNKTKPFQLQLDAFE 601
E R++++++E +E A+L EE+ + ++L K QL+L + E
Sbjct: 1104 ELLRQEVKEKEADFLAQE---AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTE 1160
Query: 602 VEKQALLNE-----HGAAQEQLNKIRDSYAKLLG 630
+ +AL E AQ QL + + + LG
Sbjct: 1161 SQLEALAAEQQPGNQAQAQAQLASLYSALQQALG 1194
Score = 110 bits (275), Expect = 5e-24
Identities = 159/731 (21%), Positives = 320/731 (43%), Gaps = 92/731 (12%)
Query: 29 LEVLKGPVSFQKSQRFKQQKESKQNLNVD---KDTTLPASARKVKSSESKES-------- 77
+E L+G + + QR + QK + + L++D ++ + +++ E S
Sbjct: 1437 VETLRGQIQELEKQR-EMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMA 1495
Query: 78 -QKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATL 136
Q+ ++ L + ++IR L ++R Q ++ ELEK + + + + L TL
Sbjct: 1496 VQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTL 1555
Query: 137 EKQLIELTRTNELLKSKFSE----NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGME 192
E +EL + ++ + G ++ R+ L +R +++ ++ +E
Sbjct: 1556 ECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLE 1615
Query: 193 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKI----DEKSETEKLLEYIEEISCASDQVE 248
V R L+E ++ ++ ++++K D + ++L+ E I DQ
Sbjct: 1616 SHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRT 1675
Query: 249 KY----KLDIAQLEENLKEKNDEILSLKQSLEENIV-----ILSKQVEDLNVKCQLLEKE 299
+ + D+ Q++ +L+E+ E+ + +Q ++E +++ ++K L +KE
Sbjct: 1676 RQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKE 1735
Query: 300 KE-----DHVNRNREHNENLNAEMQNLKQKF---------------ILEQQEREKLQQKE 339
KE +H++ +E + L ++Q L +K +L+QQ +E +Q E
Sbjct: 1736 KEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE 1795
Query: 340 LQIDSLLQQEKELSSSL------------HQKLCSFQEEMVKEK-NLFEEELKQ---TLD 383
L+ SL Q E +L Q+ QEE VKEK + + L+Q TL
Sbjct: 1796 LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
Query: 384 ELD-KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 442
E +LQ +EQA RL ++L E + R + L+ + L+ + E EK+ A Q
Sbjct: 1856 ERHGELQDHKEQARRLEEELAVEGR-RVQALEEVLGDLRAESREQEKALLALQQQCAEQA 1914
Query: 443 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 502
++++ ++L+D Q ++ E+E L+ E+ S + + A AE +Q +
Sbjct: 1915 QEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAH 1974
Query: 503 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ---LEDEE 559
++ Q + LL+ A ++ T + + Q +Q EE R Q ++D++
Sbjct: 1975 AALQGKEQHLLE----QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQD 2030
Query: 560 GRKAEK----ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 615
R E + A+ EE+ + + E+L K+ ++Q + + EKQ L E +
Sbjct: 2031 LRYQEDVQQLQQALAQRDEEL-RHQQEREQLLEKSLAQRVQENMIQ-EKQNLGQER--EE 2086
Query: 616 EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSE-------VSKLRCQLAKKKQS 668
E++ + S +L L QK + +++L++ + E S + Q K
Sbjct: 2087 EEIRGLHQSVREL--QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL 2144
Query: 669 ETKLQEELNKV 679
E +LQ EL ++
Sbjct: 2145 EPRLQRELERL 2155
Score = 99.4 bits (246), Expect = 1e-20
Identities = 133/636 (20%), Positives = 281/636 (44%), Gaps = 60/636 (9%)
Query: 65 SARKVKSSESKESQ---KNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNA 121
SA V S+ K Q K + +L +++ L + + + TEL+ ++ +L+
Sbjct: 1237 SAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
Query: 122 ALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKM 181
EK+ +LE +L+EL T L+S+ LR L+ M+ + +RE
Sbjct: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSR---------LRRAELQRMEAQGEREL-- 1345
Query: 182 RGMMAKQEGMEMKLQVTQRSLEESQGKIAQ---LEGKL------VSIEKEKIDEKSETEK 232
+ A +E + +++ Q ++ E++ + + LE L + ++ E+++ + E +
Sbjct: 1346 --LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQ 1403
Query: 233 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVK 292
L+ E+ A Q + + ++A L + L E+ +E+ +L+ ++E L KQ E
Sbjct: 1404 ALQEQGELKVA--QGKALQENLALLTQTLAEREEEVETLRGQIQE----LEKQREMQKAA 1457
Query: 293 CQLLE---KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQE 349
+LL K++ V+ +E + L L+ + Q+ +KL + QI L +
Sbjct: 1458 LELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDR 1517
Query: 350 KELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSR 409
+ + L +L E+ K+ + E + Q D L+++ E L +LEE
Sbjct: 1518 ETQRNVLEHQLL----ELEKKDQMIESQRGQVQD----LKKQLVTLECLALELEENHHKM 1569
Query: 410 AEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASE 469
+ KL++E E + E A T TL L+E+ + Q+ ES+ + A E
Sbjct: 1570 ECQQKLIKE----LEGQRETQRVALTHLTLDLEERSQEL-QAQSSQIHDLESHSTVLARE 1624
Query: 470 IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESS---NQEYVRMLLDLQTK-SALKETE 525
+++ E S +E+ + + E + + + +E +++L D +T+ + + E +
Sbjct: 1625 LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEED 1684
Query: 526 IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE 585
+++I +S ++ +L Q + +E + + ++ E+ L ++ + E
Sbjct: 1685 LEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH 1744
Query: 586 LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLK 645
++ Q D E + Q L + G L++ L Q Q+ + +LK
Sbjct: 1745 IHE----LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL---QQQLQEAREQGELK 1797
Query: 646 DENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 681
+++ L+S++ + + LA++ Q LQ+E + G
Sbjct: 1798 EQS--LQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831
Score = 98.6 bits (244), Expect = 2e-20
Identities = 152/696 (21%), Positives = 301/696 (43%), Gaps = 107/696 (15%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASA--RKVKSSESKESQKNDKDLKILEKEIRVLLQ 96
Q + K ++ Q L ++DT + + S SKE + K + L +++ VL Q
Sbjct: 425 QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQ 484
Query: 97 ERGAQDRRIQDLETE-------LEKMEARLNAALREKTSLSANNATLE----KQLIELTR 145
E R +L+ + E+ + L+ A+RE+ L LE + L EL
Sbjct: 485 EAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELIT 544
Query: 146 TNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEES 205
E L+S E +L + +T++ +A+ E +L ++ +L+
Sbjct: 545 LREALESSHLEG--------------ELLRQEQTEVTAALARAEQSIAELSSSENTLKTE 590
Query: 206 QGKIAQLEGKLVSI-EKEKIDEKSETEKLLEYIEEISCASDQVEK-------YKLDIAQL 257
+ KL ++ E +D+ ++LL+ EE ++E ++D+A+
Sbjct: 591 VADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEA 650
Query: 258 E---ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 314
E E L EKN + + Q EE L + D+ + + ++K+ ++ +R E
Sbjct: 651 EKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK----LSESRHQQEAA 706
Query: 315 NAEMQNLKQKFILEQ-------QEREKLQQKELQIDSLLQQEKELSSSLHQKL--CSFQE 365
+++ L Q+ ++ QE+E L +++ ++ LQ + L ++L S +
Sbjct: 707 TTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAK 766
Query: 366 EMVKEKNLFEEELKQTLDELDKLQ-----QKEEQAERLVK---------------QLEEE 405
E++ E +LFE + + ++ E+ K Q Q QA+ +++ Q E+E
Sbjct: 767 ELL-ESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQE 825
Query: 406 AKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKAL 465
+ A +L E++ GK A LE+ AAH + L+EK++ E Q E KAL
Sbjct: 826 RDAAARQLAQAEQE--GKTA-LEQQKAAHEKEVNQLREKWEK-----ERSWHQQELAKAL 877
Query: 466 TASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL--KE 523
+ E E ++LE ++ Q ++ A ++ +E Q +SAL +
Sbjct: 878 ESLEREKMELE------------MRLKEQQTEMEAIQAQREEE-----RTQAESALCQMQ 920
Query: 524 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLY 583
E ++ VS L+ + Q +L + + +D + +K +++ TT L ++ + +
Sbjct: 921 LETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ--- 977
Query: 584 EELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY-----AKLLGHQNLKQKI 638
EL + + L A + E +LL + Q+Q+ ++ ++ L Q +++K+
Sbjct: 978 RELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037
Query: 639 KHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 674
+ + +L+ E + L L +K+Q LQE
Sbjct: 1038 RETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQE 1073
Score = 90.1 bits (222), Expect = 6e-18
Identities = 126/651 (19%), Positives = 279/651 (42%), Gaps = 67/651 (10%)
Query: 86 ILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAA---LREKTSLSANNATLEKQLIE 142
ILE+++R R A + +++E+E E+ +A + + +L N A L + L E
Sbjct: 1376 ILEEDLRTA---RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432
Query: 143 LTRTNELLKSKFSENGNQKNLRILSLELMKL----RNKRETKMRGMMAKQEGMEMKLQVT 198
E L+ + E Q+ ++ +LEL+ L RN+ + + + E L+
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492
Query: 199 QRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE----ISCASDQVEKYKLDI 254
+++E + K+ ++ +EK++ +++ E L +E+ I QV+ K +
Sbjct: 1493 PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552
Query: 255 A-------QLEEN---LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHV 304
+LEEN ++ + I L+ E V L+ DL + Q L+ + +
Sbjct: 1553 VTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ-I 1611
Query: 305 NRNREHNENLNAEMQNLKQKFILEQQEREKLQ-QKELQIDSLLQQEKELSSSLHQKLCSF 363
+ H+ L E+Q Q+ ++++ E+LQ QKE L ++++EL +++
Sbjct: 1612 HDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ-KERIQVL 1670
Query: 364 QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 423
+++ ++ + EE+L+Q L + ++ +L+++ EE K ++ + E +K
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Query: 424 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEK 483
+ EK + LQE D + Q L+ + + L + +++ + LQE
Sbjct: 1731 LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEA 1790
Query: 484 AAKAGKNAEDVQHQILATE---SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 540
+ + +Q Q+ + + + + L Q ++ +E +KE + +
Sbjct: 1791 REQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA 1850
Query: 541 QNQLK------QQEEDFRKQLEDE---EGRKAEK-----ENTTAELTEEINKWRLLYEEL 586
LK Q ++ ++LE+E EGR+ + + AE E+ L ++
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQC 1910
Query: 587 YNKTKPFQL---------------------QLDAFEVEKQALLNEHGAAQEQLNKIRDSY 625
+ + ++ +L+A E Q+ ++ AA+ + ++++
Sbjct: 1911 AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEAL 1970
Query: 626 AKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 676
K H L+ K +H+++ + + L++ + L+ L + +L+E L
Sbjct: 1971 GK--AHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019
Score = 81.6 bits (200), Expect = 2e-15
Identities = 154/758 (20%), Positives = 322/758 (42%), Gaps = 108/758 (14%)
Query: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQ 101
Q K QK +Q T L + R++K + ++++ DL L++E LLQ++
Sbjct: 953 QDMKVQKLKEQETTGILQTQLQEAQRELKEA----ARQHRDDLAALQEESSSLLQDKMDL 1008
Query: 102 DRRIQDLETEL---------------EKMEA-----RLNAAL-REKTSLSANNATLEKQL 140
++++DL+++L EK+ R+ L REK SL+ + E++L
Sbjct: 1009 QKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRL 1068
Query: 141 IELTRTNELLKSKFSE--------NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGME 192
+ L + + + + S G QK L S ++ LR + + K +A++ +
Sbjct: 1069 LVLQEADSIRQQELSALRQDMQEAQGEQKEL---SAQMELLRQEVKEKEADFLAQEAQLL 1125
Query: 193 MKLQ---VTQRSLEES----QGKIAQLEGKLVSIEK--EKIDEKSETEKLLEYIEEISCA 243
+L+ +T++ L S + K AQL+ +L S E E + + + + +++
Sbjct: 1126 EELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASL 1185
Query: 244 SDQVEKYKLDIAQLEENLKEKNDEILSL---------------------KQSLEENIVIL 282
+++ + + L D S+ S E L
Sbjct: 1186 YSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASAL 1245
Query: 283 SKQVEDLNVKCQLLE------KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQ 336
K +DL Q + ++ E+ + ++ E+Q+L+++ Q+E+ K +
Sbjct: 1246 HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWE 1305
Query: 337 QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK---EKNLFEEELKQTLDELDKLQQKEE 393
K+ ++S L + E +SL +L + + ++ E+ L + + +++ LQ
Sbjct: 1306 GKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVV 1365
Query: 394 QAERLVKQ---LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL------LLQEK 444
+A LEE+ ++ LKL E++ E+E E++ A Q L LQE
Sbjct: 1366 EARAQASAAGILEEDLRTARSALKLKNEEV---ESERERAQALQEQGELKVAQGKALQEN 1422
Query: 445 YDSMVQSLEDVTAQFESYKALTAS-----EIEDLKLENSSLQEKAAKAGKNAEDVQHQIL 499
+ Q+L + + E+ + E++ LE SL K + + Q Q L
Sbjct: 1423 LALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQEL 1482
Query: 500 ATESSNQEYVRMLL-DLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE------EDFR 552
S E++ M + + + K ++ +I+E+ + L++QL + E E R
Sbjct: 1483 EKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQR 1542
Query: 553 KQLEDEEGRKAEKENTTAELTEEINKW---RLLYEELYNKTKPFQLQLDAFEVEKQALLN 609
Q++D + + E EL E +K + L +EL + + ++ L ++ +
Sbjct: 1543 GQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQ 1602
Query: 610 EHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE 669
E A Q++ + +S++ +L + L+++ + V +++ +L+ + L L ++ Q E
Sbjct: 1603 ELQAQSSQIHDL-ESHSTVLARE-LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQ-E 1659
Query: 670 TKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 707
LQ+E +VL + +K + ++ +K L+E
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQ---IKLSLRE 1694
Score = 80.5 bits (197), Expect = 5e-15
Identities = 155/751 (20%), Positives = 307/751 (40%), Gaps = 118/751 (15%)
Query: 27 KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKI 86
K LE GP+ Q+ + ++ + + ++++ S +V + +K D K
Sbjct: 75 KRLEATGGPIP-QRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA 133
Query: 87 LEKEIRVLLQE----RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIE 142
L +++ L + R R+ + E E + L SL T + +E
Sbjct: 134 LREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLE 193
Query: 143 LTRTNE--LLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQR 200
+ + L++ K +L L L RE G M +E ++ L + +
Sbjct: 194 MKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKT 253
Query: 201 SLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEEN 260
+E + + + +L+ ++ + EK+E L + + E+S Q +K D ++ +
Sbjct: 254 --QELEKEAHERSQELIQLKSQGDLEKAE---LQDRVTELSALLTQSQKQNEDYEKMIKA 308
Query: 261 LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK-------EKEDHVNRNREHNEN 313
L+E + + + L E+ LS+ ++ + Q + K E+ D++ + H +
Sbjct: 309 LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENS 368
Query: 314 LNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEE---MVKE 370
L + I Q + + + + S+L + ++ L Q+L QE + ++
Sbjct: 369 LELDSS------IFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQ 422
Query: 371 KNLFEEELK------------------QTLD---ELDKL-------QQKEEQAERLVKQL 402
+ +EEE K QT+D E+D L Q+ E+ + ++ L
Sbjct: 423 HDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVL 482
Query: 403 EEEA---------------------KSRAEELKL-------LEEKLKGKEAELEKS---- 430
E+EA + + EEL L L+E L G EA+ +S
Sbjct: 483 EQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSEL 542
Query: 431 -------SAAHTQATLLLQEKYD--SMVQSLEDVTAQFESYKALTASEIEDLK---LENS 478
++H + LL QE+ + + + E A+ S + +E+ DL+ ++ S
Sbjct: 543 ITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS 602
Query: 479 SLQEKAA--KAGKNAEDVQHQILATESSNQEYV-RMLLDLQTKSALKE--TEIKEITVSF 533
+L E A K G N Q+L E NQ RM Q ++AL+ E ++ +
Sbjct: 603 ALNEALALDKVGLN-----QQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREAL 657
Query: 534 LQKITDLQNQLKQQEE---DFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 590
+K T L+ QL++ EE + + L D + K E + +E + E+L+ +
Sbjct: 658 WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA 717
Query: 591 KPFQLQLDAFEVEKQALLNEHGAAQEQLNKI----RDSYAKLLGHQNLKQKIK-HVVKLK 645
K + L EK+AL+ E A + +L + +D +L G + K+ ++ + + +
Sbjct: 718 KRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQ 777
Query: 646 DENSQLKSEVSKLRCQLAKKKQSETKLQEEL 676
+NS ++ +L Q+ Q++ +Q E+
Sbjct: 778 QQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV 808
Score = 61.6 bits (148), Expect = 2e-09
Identities = 116/567 (20%), Positives = 240/567 (42%), Gaps = 86/567 (15%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKD--LKILEKEIRVLLQE 97
K Q + Q + Q +D L A ++ + ++ +E + +K L+ ++ + L+E
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 98 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 157
R + +QD + + ++E L R +L L + E + L+ + +E
Sbjct: 1857 RHGE---LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ 1913
Query: 158 GNQKNLRILSLE--------LMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKI 209
+ + +L+ ++K R++ +R E + +L+E+ GK
Sbjct: 1914 AQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
Query: 210 -AQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEI 268
A L+GK ++ + E++E + LE AS + LD Q
Sbjct: 1974 HAALQGK-----EQHLLEQAELSRSLE-------ASTATLQASLDACQAHS--------- 2012
Query: 269 LSLKQSLEENIVILSKQVEDLNVK----CQLLEK---EKEDHVNRNREHNENLNAEMQNL 321
+ LEE + I +++D +++ Q L++ ++++ + +E + L +
Sbjct: 2013 ----RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQR 2068
Query: 322 KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE-EMVKEKNLFE----- 375
Q+ ++++++ +++E +I L Q +EL +L QK E +++N E
Sbjct: 2069 VQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS 2128
Query: 376 ------EELKQTLDELD-KLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEA 425
EE LD L+ +LQ++ E+ + ++Q E E + +A++L L + K +
Sbjct: 2129 HKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVS 2188
Query: 426 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 485
L++ A QA++L + DS Q L+D LT +E +L + A
Sbjct: 2189 SLQE-VAMFLQASVL---ERDSEQQRLQDEL-------ELTRRALEKERLHSPGATSTAE 2237
Query: 486 KAGKNAEDVQ-HQILATES-------SNQEYVRMLLDLQTKSALKETEIKEITVSFLQKI 537
+ + VQ ++ E+ Q + + L LQ A E + + +Q
Sbjct: 2238 LGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ-- 2295
Query: 538 TDLQNQLKQQEEDFRKQLEDEEGRKAE 564
L++ L+Q E + R++L+ E R A+
Sbjct: 2296 --LRSTLEQVERE-RRKLKREAMRAAQ 2319
Score = 42.7 bits (99), Expect = 0.001
Identities = 112/543 (20%), Positives = 218/543 (40%), Gaps = 84/543 (15%)
Query: 193 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 252
MK Q Q LEE + Q + + K+ E ++ + + +V +Y+
Sbjct: 11 MKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATL--VRKLQAKVLQYRS 68
Query: 253 DIAQLEENLKEKNDEILSLKQSLEE-NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 311
+LE+ L+ I +++EE N+ L ++E+ +C+ L E + + E
Sbjct: 69 WCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLA-EVNTQLRLHMEKA 127
Query: 312 ENLNAEMQNLKQKFILE-QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 370
+ +N ++ +K ++ + R++L +KE Q + K H +L S E+V
Sbjct: 128 DVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTF 187
Query: 371 KNLFEEELKQTLDELDKLQQKEEQAERLVK----QLEEEAKSRA----------EELKLL 416
+ F E T +L +L+ + + + +L A+SR E +LL
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 417 EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED-VT----------AQFESYKAL 465
L K ELEK + +Q + L+ + D L+D VT Q E Y+ +
Sbjct: 248 --LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKM 305
Query: 466 TAS---EIEDLKLENSSLQEKAAKAGKNAEDVQ----------HQILATESSN------- 505
+ +E L+ ++ L E A +NA++ + Q++ E N
Sbjct: 306 IKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGH 365
Query: 506 ------QEYVRMLLDLQ-TKSALKETEIKEITVSFLQKITDLQNQLK--QQEEDFRKQLE 556
+ D Q AL T ++ + Q + DL+ QL Q+ + +Q
Sbjct: 366 ENSLELDSSIFSQFDYQDADKAL--TLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQH 423
Query: 557 D---EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGA 613
D EEG+ L + + K + L +T Q ++D+ E++ L
Sbjct: 424 DQWEEEGK---------ALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREE 474
Query: 614 AQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQ 673
++QL + +L +++ ++L+ +++Q + E + LA +++ +LQ
Sbjct: 475 LRQQLEVLEQEAWRL-------RRVNVELQLQGDSAQGQKEEQQEELHLAVRERE--RLQ 525
Query: 674 EEL 676
E L
Sbjct: 526 EML 528
Score = 38.9 bits (89), Expect = 0.017
Identities = 66/335 (19%), Positives = 142/335 (42%), Gaps = 44/335 (13%)
Query: 39 QKSQRFKQQKESKQNLNVD------KDTTLPASARKVKSSESKESQKNDK-DLKILEKEI 91
QK Q + +E++Q N++ K + + + K+ S E + ++ ++ + + E
Sbjct: 2105 QKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEA 2164
Query: 92 RVLLQERGAQDRRIQDLETE-----LEKMEARLNAALREKTSLSANNATLEKQLIELTRT 146
R + AQD + +T+ L+++ L A++ E+ S L+ +L ELTR
Sbjct: 2165 REIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDS---EQQRLQDEL-ELTR- 2219
Query: 147 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKM---RGMMAKQEGMEMKLQVTQRSLE 203
L K + G + S R ++ ++ G+ A+ M+ Q ++ LE
Sbjct: 2220 RALEKERLHSPGATSTAELGS------RGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLE 2273
Query: 204 ESQGKIAQLEGKLVSIEKEKIDEKSETEKL--------LEYIEEISCASDQVEKYKLDIA 255
Q +A+LE +++ + +S E++ E + S ++ K
Sbjct: 2274 HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSP 2333
Query: 256 QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN 315
++ +KN + + + L++ +V+L Q+ L K+K+D++ R+ + + L
Sbjct: 2334 TQQDGRGQKNSDAKCVAE-LQKEVVLLQAQLT-------LERKQKQDYITRSAQTSRELA 2385
Query: 316 AEMQNLKQKFILEQQ--EREKLQQKELQIDSLLQQ 348
+L + Q E L+ + ++D L Q
Sbjct: 2386 GLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 115 bits (287), Expect = 2e-25
Identities = 148/654 (22%), Positives = 282/654 (43%), Gaps = 93/654 (14%)
Query: 73 ESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSAN 132
E++ QK +LKI ++I L QE +R + L+ L+ + L L SL
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK-NLTFQLE---SLEKE 695
Query: 133 NATLEKQLIELTRTNELLKS----------KFSENGNQKNLRILSLELMKLRNKRETKMR 182
N+ L+++ +EL R E LK + E ++K LEL+K K+ ++
Sbjct: 696 NSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLE 755
Query: 183 GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISC 242
+G++++ Q Q++LE S KI QLE +L +E E +K LE ++ S
Sbjct: 756 ---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM----ENQTLQKNLEELKISSK 808
Query: 243 ASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKED 302
+Q+EK + Q L++ ++ + L + I +E+ NVK LEKE
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE--- 865
Query: 303 HVNRNREHNENLNAEMQNLKQKFI----LEQQEREKLQQKELQIDSLLQQEKELSSSLHQ 358
N+ L+ E+ K+ + LE++ +E +++ + I +L+ ++L S
Sbjct: 866 --------NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVS---- 913
Query: 359 KLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEE 418
E +K + + +L++ EL+K+ +E + L +E + KLLE
Sbjct: 914 -------EKLKTQQM-NNDLEKLTHELEKIGLNKE------RLLHDEQSTDDSRYKLLES 959
Query: 419 KLKG---KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 475
KL+ K E+++ A +A L Y+ ++ +++ ++Y+AL + E+ +
Sbjct: 960 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR--QELKTVKKNYEALKQRQDEERMV 1017
Query: 476 ENS-SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI----- 529
++S + + K + +++ ++L + E R LQ + +T++K++
Sbjct: 1018 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1077
Query: 530 ------------TVSFLQKITDLQNQ----------LKQQEEDFRKQLEDEEGRKAEKEN 567
TVS ++ T LQ Q L Q Q +++ EN
Sbjct: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1137
Query: 568 TTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAK 627
+ +E + LY+ L + +L + E ++L+++HG + + +
Sbjct: 1138 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD 1197
Query: 628 LLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 681
L N Q +K +L+D LK E K+ L + K ET + E K+ G
Sbjct: 1198 LEDRYN--QLLKQKGQLEDLEKMLKVEQEKM---LLENKNHET-VAAEYKKLCG 1245
Score = 112 bits (281), Expect = 9e-25
Identities = 154/669 (23%), Positives = 298/669 (44%), Gaps = 82/669 (12%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRV--LLQ 96
+K+++ K+ + + ++ + + + S +++ D + EK +RV L
Sbjct: 269 EKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-LREKAVRVDKLES 327
Query: 97 ERGAQDRRIQDLE---TELEKMEARLNAALREKTSLS---ANNATLEKQLIELTRTNELL 150
E R+ D+E +E+++ L KT L +L EL + N L
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387
Query: 151 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV---------TQRS 201
K+K + ++++ + K+ E M MA+++ M+ L + T
Sbjct: 388 KAKLHDMEMERDM-----DRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSEL 442
Query: 202 LEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL 261
E Q + +L S K++ E + L + +EE+ D VE I ++E
Sbjct: 443 SEAPQKSLGHEVNELTSSRLLKLE--MENQSLTKTVEELRTTVDSVEGNASKILKME--- 497
Query: 262 KEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL 321
K ++ LS K + EN ++ KQ CQ L K D + + + + +N
Sbjct: 498 --KENQRLSKKVEILENEIVQEKQSLQ---NCQNLSK---DLMKEKAQLEKTIETLRENS 549
Query: 322 KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 381
+++ + +QE E L Q S L+Q ++S+ K ++ KE + E +K+T
Sbjct: 550 ERQIKILEQENEHLNQTV----SSLRQRSQISAEARVK------DIEKENKILHESIKET 599
Query: 382 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL-- 439
+L K++ ++ Q ++ ++ +E+ + RAEEL+ L+ KE EL + + + T
Sbjct: 600 SSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLE-KENELLQKKITNLKITCEK 657
Query: 440 --LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV--- 494
L+++ + + + +S+K LT ++E L+ ENS L E+ + +N E +
Sbjct: 658 IEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEENLELRRNVESLKCA 716
Query: 495 -----QHQILATE-SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ-LKQQ 547
Q Q+ E S +E ++ L+L K++ K+TE E++ L D++NQ L++
Sbjct: 717 SMKMAQLQLENKELESEKEQLKKGLEL-LKASFKKTERLEVSYQGL----DIENQRLQKT 771
Query: 548 EEDFRKQLE--DEEGRKAEKENTTAELT-EEINKWRLLYEELYNKTKPFQLQLDAFEVEK 604
E+ K+++ + E + E EN T + EE+ E+L + K + + E +K
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK 831
Query: 605 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVS--KLRCQL 662
+ L E+ ++Q +I+D+ L N+K + L+ EN L E+ K C
Sbjct: 832 KQLEKENKRLRQQA-EIKDT---TLEENNVK-----IGNLEKENKTLSKEIGIYKESCVR 882
Query: 663 AKKKQSETK 671
K+ + E K
Sbjct: 883 LKELEKENK 891
Score = 94.0 bits (232), Expect = 4e-19
Identities = 147/683 (21%), Positives = 295/683 (43%), Gaps = 91/683 (13%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDL 84
D + LE L+ V K K + +N ++ + ++ + K++++ +
Sbjct: 700 DEENLE-LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSY 758
Query: 85 KILEKEIRVLLQERGAQDRRIQDLETELEKME----------ARLNAALREKTSLSANNA 134
+ L+ E + L + +++IQ LE+EL+ +E L + + L N
Sbjct: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK 818
Query: 135 TLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMK 194
+LE++ +L + + L+ + Q ++ +LE ++ K ++K+ G+ +
Sbjct: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878
Query: 195 LQVTQRSLEESQGKI---AQLEGK-LVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKY 250
V + LE+ ++ A ++ K LV++ ++ + EK +T+++ +E++ + ++EK
Sbjct: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL---THELEKI 935
Query: 251 KLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 310
L+ +L + + +D L +S E+ L K +E K LE E+ N +
Sbjct: 936 GLNKERLLHDEQSTDDSRYKLLESKLES--TLKKSLEIKEEKIAALEARLEESTN----Y 989
Query: 311 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 370
N+ L E++ +K+ + E L+Q++ +E+ + SS + E
Sbjct: 990 NQQLRQELKTVKKNY-------EALKQRQ-------DEERMVQSS---------PPISGE 1026
Query: 371 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS 430
N +E E ++T EL K++ + + ER L+ E ++ +LK LE + +A++
Sbjct: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI--- 1083
Query: 431 SAAHTQATLLLQEKYDSMV---QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKA 487
A + T+ LQE+ ++ L+ + S ++ L ++ SSL+ +
Sbjct: 1084 -LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1142
Query: 488 GKNAEDVQ---------HQILAT--ESSNQEYVRMLLDLQT-KSALKETEIKEITVSFLQ 535
K ED++ H+ L E EY ++ T KSA K E++ +
Sbjct: 1143 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH------R 1196
Query: 536 KITDLQNQL---KQQEEDFRKQLEDEEGR----KAEKENTTAE---LTEEINKWRLLYEE 585
+ D NQL K Q ED K L+ E+ + E AE L E ++ Y +
Sbjct: 1197 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1256
Query: 586 LYNKTKPFQLQ-------LDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKI 638
L +T+ Q L+ ++E+ L E +EQ ++ + KL L ++
Sbjct: 1257 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1316
Query: 639 KHVVKLKDENSQLKSEVSKLRCQ 661
K L++EN L ++ L Q
Sbjct: 1317 KG--NLEEENRHLLDQIQTLMLQ 1337
Score = 77.0 bits (188), Expect = 6e-14
Identities = 137/628 (21%), Positives = 264/628 (42%), Gaps = 124/628 (19%)
Query: 138 KQLIELTRTNELL--KSKFSENGNQKNLRILSLEL---MKLRNKRE--TKMRGM-MAKQE 189
+QLI ++ N L+ K+ FSE G ++ ++L L L ++ + K E +++G+ +
Sbjct: 95 QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKA 154
Query: 190 GMEMKLQVTQRSLEE------------SQGKIAQLEGKLVSIEKEKIDEKSE-TEKLLEY 236
+ +Q + E SQ I L + K IDE+ E +E ++E
Sbjct: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214
Query: 237 IEEIS---------------CASDQVEKY-------------KLDIAQLEENLKEKNDEI 268
EE C S +++ K I +L + L+EK +++
Sbjct: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQL 274
Query: 269 LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 328
L KQ LE + E + R ++ N NL ++ ++ + +
Sbjct: 275 LDCKQELE----------------------QMEIELKRLQQENMNLLSDARSAR----MY 308
Query: 329 QQEREKLQQKELQIDSLLQQEKELSSSLH---------QKLCSFQEEMVKEKNLFEEELK 379
+ E + L++K +++D L + LH ++L + +++ K + E++L+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 380 QTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 439
T DKL + E++ +L +L + R + K +EE L + LE + +L
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE-LMEENMTLEMAQKQSMDESL 427
Query: 440 LLQEKYDSMVQSLEDVTAQFES----YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 495
L + + + ++ E A +S LT+S + L++EN SL + + + V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 496 ---HQILATESSNQ-----------EYVRMLLDLQ-----TKSALKETEIKEITVSFLQK 536
+IL E NQ E V+ LQ +K +KE E T+ L++
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 537 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQ 596
++ Q ++ +QE + Q R+ + + A + + + ++L+E + K +
Sbjct: 548 NSERQIKILEQENEHLNQTVSSL-RQRSQISAEARVKDIEKENKILHESI----KETSSK 602
Query: 597 LDAFEVEKQAL------LNEHGAAQEQL-NKIR--DSYAKLLGHQ--NLKQKIKHVVKLK 645
L E EK+ + E G E+L N++ + +LL + NLK + + L+
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 646 DENSQLKSEVSKLRCQLAKKKQSETKLQ 673
ENS+L+ E KL+ L K +L+
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLE 690
Score = 67.8 bits (164), Expect = 3e-11
Identities = 116/507 (22%), Positives = 217/507 (42%), Gaps = 76/507 (14%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSES----KESQKNDKDL-KILEKEIRV 93
Q Q K K++ + L +D + S E +ESQ+ ++L K+ ++ I V
Sbjct: 992 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1051
Query: 94 ------LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 147
L E+ A +++ LET+ ++A++ A R+ SL N TL+ Q +L N
Sbjct: 1052 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1111
Query: 148 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 207
L S+ + NQ N ++L ++ L N+ E+ ++ L+ SL +
Sbjct: 1112 STLNSQSTSLMNQ-NAQLL-IQQSSLENENESVIKE--------REDLKSLYDSLIKDHE 1161
Query: 208 KIAQLEGKLVSIEKEKIDE----KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 263
K+ L + S + I + KS + L ++ +Q+ K K + LE+ LK
Sbjct: 1162 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1221
Query: 264 KNDEILSLKQSLEENIVILSKQV----EDLNVKCQLLEKEKE----DH------VNRNRE 309
+ +++L L+ E + K++ + LN L KE E DH +N ++
Sbjct: 1222 EQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280
Query: 310 HNENLNAEMQNLKQKFILEQQEREKLQ-QKEL--QIDSLLQQEKELSSSLHQKLC----S 362
L AE LK+++ KL Q EL Q+ L++E Q L +
Sbjct: 1281 EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRT 1340
Query: 363 FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 422
E+ ++ K+LF E +Q +D+L++L++++E+ LEEK+
Sbjct: 1341 LLEQNMESKDLFHVEQRQYIDKLNELRRQKEK---------------------LEEKIMD 1379
Query: 423 KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIED----LKLENS 478
+ + S + L K +++S +D+ + + LT + + L+L +
Sbjct: 1380 QYKFYDPSPPRRRGNWITL--KMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1437
Query: 479 SLQEKAAKAGKNAEDVQHQILATESSN 505
Q+ ++ + ED Q L T+ S+
Sbjct: 1438 DSQDSSSVGSNSLED--GQTLGTKKSS 1462
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 114 bits (286), Expect = 2e-25
Identities = 132/569 (23%), Positives = 250/569 (43%), Gaps = 64/569 (11%)
Query: 171 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKID--- 225
M L K + ++ A++E MK + T+ L S+ + +LE K+VS+ +EK D
Sbjct: 834 MNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQL 893
Query: 226 -EKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK---NDEILSLKQSLEENIVI 281
+SETE L++ E + + +L E L+E+ N E+++ K++LE+
Sbjct: 894 QVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS 953
Query: 282 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL----KQKFILE---QQEREK 334
L + ++DL + +EKEK N+ + +E + A +N+ K+K L+ QQ +
Sbjct: 954 LKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD 1013
Query: 335 LQQKELQIDSLL-------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 387
LQ +E +++ L+ QQ +L SL Q+ + ++ + K E +LK + + +
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK-KLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 388 LQQKEEQAERLVKQLEEE-----AKSRAEELKLLEEKLKGKE-----AELEKSSAAHTQA 437
L+ ++Q E +K+ E E AK E++ L+ + K KE ELE+ A
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTL 1132
Query: 438 TLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK------------LENSSLQEKAA 485
++++ + + LE+++ + E T+++IE K LE ++LQ +A
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 486 KA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK------ 536
A K A+ V L + N + V+ L+ + E + + L K
Sbjct: 1193 AATLRKKQADSVAE--LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIE 1250
Query: 537 -----ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 591
+ D +++K ++E + + D +KA + EL+ + + L +L +
Sbjct: 1251 RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ 1310
Query: 592 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 651
QL+ + + + A L R L +Q+ K +L+ S+
Sbjct: 1311 ALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK--AELQRALSKA 1368
Query: 652 KSEVSKLRCQLAKKKQSETKLQEELNKVL 680
SEV++ R + T+ EE K L
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Score = 111 bits (277), Expect = 3e-24
Identities = 144/696 (20%), Positives = 300/696 (43%), Gaps = 84/696 (12%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVK-----SSESKESQKNDK---DLKILEKE 90
Q++ + E ++ L D L + RK++ S ES +NDK + K+ +KE
Sbjct: 1033 QQTDDLEGSLEQEKKLRAD----LERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKE 1088
Query: 91 IRVLLQERGAQDRRIQDLETE--LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNE 148
+ + D ++ L+ + +++++AR+ E + A +EKQ +L R E
Sbjct: 1089 FELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELE 1148
Query: 149 LLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG- 207
+ + E + +I ++ KRE + + M E ++ + T +L + Q
Sbjct: 1149 EISERLEEASGATSAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQAD 1202
Query: 208 -------KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEEN 260
+I L+ +EKEK + K E + + IE +S + +E+ +
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE 1262
Query: 261 LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQN 320
+K K+++ L L L Q +L+ + + EKE +++ + + L +++
Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVE----EKESLISQLTKSKQALTQQLEE 1318
Query: 321 LKQKFILEQQEREK------LQQKELQIDSLLQQ---EKELSSSLHQKLCSFQEEMVKEK 371
LK++ +E++ + K LQ D L +Q E+E + L + L E+ + +
Sbjct: 1319 LKRQ--MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWR 1376
Query: 372 NLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS- 430
+E + Q +EL++ ++K Q + ++ E A S+ L+ +++L+G+ +L +
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL 1436
Query: 431 SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKN 490
+HT L D ++ + V A+++ + +E+E + E+ SL + K
Sbjct: 1437 ERSHTACATL-----DKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNA 1491
Query: 491 AEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED 550
E+V Q+ N+ + DL TE T LQ+ + ++Q++ D
Sbjct: 1492 YEEVVDQLETLRRENKNLQEEISDL--------TEQIAETGKNLQEAEKTKKLVEQEKSD 1543
Query: 551 FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE 610
+ LE+ EG +E+ + E+++ + EL K ++ E +Q N
Sbjct: 1544 LQVALEEVEGSLEHEESKILRVQLELSQ---VKSELDRKV------IEKDEEIEQLKRNS 1594
Query: 611 HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSET 670
AA E L + D+ + +N ++K +++ +++++ QL +
Sbjct: 1595 QRAA-EALQSVLDAEIR---SRNDALRLK---------KKMEGDLNEMEIQLGHSNRQMA 1641
Query: 671 KLQEELNKVLG-IK----HFDPSKAFHHESKENFAL 701
+ Q+ L V G +K H D + + + KE A+
Sbjct: 1642 ETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAI 1677
Score = 106 bits (265), Expect = 7e-23
Identities = 139/683 (20%), Positives = 292/683 (42%), Gaps = 112/683 (16%)
Query: 36 VSFQKSQRFKQQKESKQNLNVDKDTTLPASARKV---KSSESKESQKNDKDLKILEKEIR 92
++ K ++ K E+K ++ T L + K+ K S + Q+ DL++ E ++
Sbjct: 963 LTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVN 1022
Query: 93 VLLQERGAQDRRIQDLETELEKMEARLNAAL-REKTSLSANNATLEKQLIELTRTNELLK 151
L++ +++ DLE LE+ E +L A L R K L + ++ +++L + ++
Sbjct: 1023 GLIKINAKLEQQTDDLEGSLEQ-EKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIE 1081
Query: 152 SKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ 211
K K+E ++ + AK + ++ Q+ ++E Q +I +
Sbjct: 1082 EKL--------------------KKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEE 1121
Query: 212 LEGKL-------VSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK 264
LE ++ IEK++ D E E++ E +EE S A+ AQ+E N K++
Sbjct: 1122 LEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATS---------AQIEMN-KKR 1171
Query: 265 NDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQK 324
E +++ LEE + L K++ D V E +NL Q +KQK
Sbjct: 1172 EAEFQKMRRDLEEATL-------QHEATAATLRKKQADSVAELGEQIDNL----QRVKQK 1220
Query: 325 FILEQQEREKLQQKELQIDSLLQQEKELSSSLH--QKLCSFQEEMVKEKNLFEEELKQTL 382
E+EK + K ++ID + + LS S ++ C E+ E +E+ Q +
Sbjct: 1221 L-----EKEKSELK-MEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLI 1274
Query: 383 DELD-----------KLQQKEEQAERLVKQLEEEAKSRAEEL----KLLEEKLKGKEAEL 427
+L+ +L + E+ E L+ QL + ++ ++L + +EE+ K K A
Sbjct: 1275 HDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMA 1334
Query: 428 EKSSAAHTQATLLLQEKYD-----------SMVQSLEDVTAQFESYKALTASEIEDLKLE 476
++ LL+E+Y+ ++ ++ +V Y+ E+L+
Sbjct: 1335 HALQSSRHDCD-LLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 477 NSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK 536
L ++ +A +N E + + E + Q L + + +++ E + L K
Sbjct: 1394 KKKLAQRLQEAEENTETANSKCASLEKTKQR-----LQGEVEDLMRDLERSHTACATLDK 1448
Query: 537 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQ 596
Q + +++++L++ + + + L+ E+ K R YEE+ +
Sbjct: 1449 ---KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVD-------- 1497
Query: 597 LDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVS 656
+ + L E+ QE+++ + + A+ +NL++ K ++ E S L+ +
Sbjct: 1498 ------QLETLRRENKNLQEEISDLTEQIAET--GKNLQEAEKTKKLVEQEKSDLQVALE 1549
Query: 657 KLRCQLAKKKQSETKLQEELNKV 679
++ L ++ ++Q EL++V
Sbjct: 1550 EVEGSLEHEESKILRVQLELSQV 1572
Score = 106 bits (264), Expect = 9e-23
Identities = 139/693 (20%), Positives = 295/693 (42%), Gaps = 68/693 (9%)
Query: 68 KVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKT 127
KVK + ++ + + +++ K+ R L + + R I DLE L K+E +A +
Sbjct: 922 KVKELTERLEEEEEMNSELVAKK-RNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVK 980
Query: 128 SLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLE------LMKLRNKRETK- 180
+LS LE+ + +LT+ + K + +Q+ L L +E L+K+ K E +
Sbjct: 981 NLSEEMTALEENISKLTK-----EKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQT 1035
Query: 181 --MRGMMAKQEGMEMKLQVTQRSLE----ESQGKIAQLEGKLVSIEKEKIDEKSETEKLL 234
+ G + +++ + L+ +R LE SQ I LE IE++ ++ E +L
Sbjct: 1036 DDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQ 1095
Query: 235 EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQ 294
I++ S Q +K ++ E L+E+ + +L+ +E+ L++++E+++ + +
Sbjct: 1096 AKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLE 1155
Query: 295 LLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL--------QIDSL- 345
+ N++ ++L++ + + L++K+ QID+L
Sbjct: 1156 EASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215
Query: 346 -----LQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVK 400
L++EK + S E + K K+ E + D+ +++ K+EQ +L+
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275
Query: 401 QLEEEAKSRAEELKLLEEKLKGKE---AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTA 457
L + + L +++ KE ++L KS A TQ L+ + + E+ A
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME------EETKA 1329
Query: 458 QFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT 517
+ AL +S + L +E+ AKA ++Q A +N E + +T
Sbjct: 1330 KNAMAHALQSSRHDCDLLREQYEEEQEAKA-----ELQR---ALSKANSEVAQWRTKYET 1381
Query: 518 KSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN 577
+ + E++E Q++ + + + + ++ + E E+ +L
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHT 1441
Query: 578 KWRLLYEELYNKTK---PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNL 634
L ++ N K ++ +LD + E +A E + +L K+R++Y
Sbjct: 1442 ACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAY--------- 1492
Query: 635 KQKIKHVVKLKDENSQLKSEVSKLRCQLA------KKKQSETKLQEELNKVLGIKHFDPS 688
++ + + L+ EN L+ E+S L Q+A ++ + KL E+ L + +
Sbjct: 1493 EEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE 1552
Query: 689 KAFHHESKENFALKTPLKEGNTNCYRAPMECQE 721
+ HE + ++ L + + R +E E
Sbjct: 1553 GSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585
Score = 85.5 bits (210), Expect = 2e-16
Identities = 141/660 (21%), Positives = 284/660 (43%), Gaps = 98/660 (14%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSESK---ESQKNDKDLKILEKEIRVLLQERGAQ 101
++Q E +Q + L + +V +K ++ + ++L+ +K++ LQE
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407
Query: 102 DRRIQDLETELEKMEARLNAA----LREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 157
LEK + RL +R+ ATL+K+ + K K E+
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDES 1467
Query: 158 -----GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 212
QK R LS EL K+RN E ++ + E + + + Q + + +IA+
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEE----VVDQLETLRRENKNLQEEISDLTEQIAET 1523
Query: 213 EGKLVSIEKEKI---DEKSETEKLLEYIE-EISCASDQVEKYKLDIAQLEENLK----EK 264
L EK K EKS+ + LE +E + ++ + +L+++Q++ L EK
Sbjct: 1524 GKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEK 1583
Query: 265 NDEILSLKQSLEENIVILSKQVEDLNVKCQ----LLEKEKEDHVNRNREHNENLNAEMQN 320
++EI LK++ + L + V D ++ + L+K+ E +N + N +M
Sbjct: 1584 DEEIEQLKRNSQRAAEAL-QSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAE 1642
Query: 321 LKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ 380
++ Q + L+ +L +D L+ ++L L +V+ +N
Sbjct: 1643 TQKHLRTVQGQ---LKDSQLHLDDALRSNEDLKEQL---------AIVERRNGL------ 1684
Query: 381 TLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL 440
L+EL++++ EQ ER + E+E ++ ++LL H+Q T L
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLL-----------------HSQNTSL 1727
Query: 441 LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILA 500
+ K + LE AQ ++ E+E+ E+ + +EKA KA +A + ++
Sbjct: 1728 INTK-----KKLEADIAQCQA-------EVENSIQESRNAEEKAKKAITDAAMMAEELKK 1775
Query: 501 TESSNQEYVRMLLDL-QTKSALKE--TEIKEITVSFLQK-ITDLQNQLKQQEEDFRKQLE 556
+ ++ RM +L QT L+ E +++ + +K I L+N++++ E +L+
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE----NELD 1831
Query: 557 DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 616
E+ R AE + ++ + EE + Q +D + + ++ + A+E
Sbjct: 1832 VEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891
Query: 617 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL-KSEVSKLRCQLAKKKQSETKLQEE 675
Q N + ++++H ++ E + + +S+V+KLR AK + ++ EE
Sbjct: 1892 QANT----------QLSRCRRVQHELEEAAERADIAESQVNKLR---AKSRDVGSQKMEE 1938
Score = 30.0 bits (66), Expect = 7.9
Identities = 36/159 (22%), Positives = 69/159 (43%), Gaps = 26/159 (16%)
Query: 534 LQKITDLQNQLKQQEEDFRKQLED---EEGRKAEKENTTAELTEEINKWRLLYEELYNKT 590
L K + + ++ +EDF + E+ E R+ E E L +E N
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKND------------ 890
Query: 591 KPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ 650
QLQ+ + E + L++ A+E+ + S K+L +K+ + + + ++ NS+
Sbjct: 891 --LQLQVQS---ETENLMD----AEERCEGLIKS--KILLEAKVKELTERLEEEEEMNSE 939
Query: 651 LKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSK 689
L ++ L + + K+ L+ L KV KH +K
Sbjct: 940 LVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENK 978
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 114 bits (286), Expect = 2e-25
Identities = 171/722 (23%), Positives = 320/722 (44%), Gaps = 108/722 (14%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQER 98
++ R ++++E L S R+++ E K S + +++ E R LQ
Sbjct: 638 RQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRD 697
Query: 99 GAQDRRIQ-------------DLETELEKMEARLNAALREKTS-LSANNATLEKQLIELT 144
Q + + +LE + K+ A A+L++ S LSA N +L + ++L
Sbjct: 698 MLQAEKAEVAEALTKAEAGRVELELSMTKLRAE-EASLQDSLSKLSALNESLAQDKLDLN 756
Query: 145 R-TNELLKSKFSENGNQKN--------------LRILSLELMKLRNKRETKMRGMMAKQE 189
R +L + K + G Q+ L L LE R E +R QE
Sbjct: 757 RLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
Query: 190 GMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEK 249
+E +L + + Q ++AQL +L E+E + E ++ +E +E + + + K
Sbjct: 817 ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAK 876
Query: 250 ------YKLDIAQLE-ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKED 302
+L A+ E L E+ + K++LE ++ + +Q+ L + + LE E +
Sbjct: 877 EHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQA 936
Query: 303 HVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCS 362
+ E L E+ L+Q+ I+ QE+ L KEL L+Q E+E +SL ++ +
Sbjct: 937 LLLAK----ETLTGELAGLRQQ-IIATQEKASLD-KELMAQKLVQAEREAQASLREQRAA 990
Query: 363 FQEE---MVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL--- 416
+E+ + +EK EL+ +L Q+E+ E L+ +LE E + +EE+ L
Sbjct: 991 HEEDLQRLQREKEAAWRELEAERAQLQSQLQREQ--EELLARLEAEKEELSEEIAALQQE 1048
Query: 417 -EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK------------ 463
+E L E+E +++ + L EK SL ++ + E K
Sbjct: 1049 RDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRS 1108
Query: 464 ---ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSA 520
ALT SE+ DL+ + +E+AA A +A++V+ QE R L Q S
Sbjct: 1109 TVNALT-SELRDLRAQ----REEAAAA--HAQEVRRL--------QEQARD-LGKQRDSC 1152
Query: 521 LKETEIKEITVSFLQKITD-LQNQLKQQEEDFRKQLEDEEGRKAEKE------NTTAELT 573
L+E E + L+ D L+ +L + + RK E +EGR+ +++ + E
Sbjct: 1153 LREAEELRTQLRLLEDARDGLRRELLEAQ---RKLRESQEGREVQRQEAGELRRSLGEGA 1209
Query: 574 EEINKWRLLYEELYNKTKPFQLQLDAFEV------EKQALLNE-HGAAQEQLNKIRDSY- 625
+E R EEL + K + + + ++ +K ALL E A ++ ++R
Sbjct: 1210 KEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQ 1269
Query: 626 ----AKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 681
++L + L++ + + L EN++L E+++L+ +LA +++E +E + LG
Sbjct: 1270 EVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAE---KESRRETLG 1326
Query: 682 IK 683
++
Sbjct: 1327 LR 1328
Score = 89.0 bits (219), Expect = 1e-17
Identities = 144/680 (21%), Positives = 286/680 (42%), Gaps = 100/680 (14%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQER 98
Q++ ++++E + L ++++ ++ +E + + ++ L L E R LQE+
Sbjct: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQ-EALEQQLPTLRHE-RSQLQEQ 835
Query: 99 GAQ-DRRIQDLETELE--KMEAR-----LNAALREKTSLSANNATLEKQLIELTRTNELL 150
AQ R++ E ELE + EA+ L A REK +L+ +A L QL+ R L
Sbjct: 836 LAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL 895
Query: 151 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 210
SE + L +LE +R+ + + A++E +E + Q + E G++A
Sbjct: 896 ----SEEATRLRLEKEALEGSLFEVQRQ--LAQLEARREQLEAEGQALLLAKETLTGELA 949
Query: 211 QLEGKLVSI-EKEKIDEKSETEKLLEYIEEISCA-SDQVEKYKLDI-------------- 254
L ++++ EK +D++ +KL++ E + +Q ++ D+
Sbjct: 950 GLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWREL 1009
Query: 255 ----AQLEENLKEKNDEILSL----KQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNR 306
AQL+ L+ + +E+L+ K+ L E I L ++ ++ L E EK+ ++
Sbjct: 1010 EAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE---GLLLAESEKQQALSL 1066
Query: 307 NREHNENLNAEMQNLKQKFI-----LEQQEREKLQQKEL----------QIDSLLQQEKE 351
L+ ++ + +E+Q+R+ ++E ++ L Q +E
Sbjct: 1067 KESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREE 1126
Query: 352 LSSSLHQKLCSFQEEM----------VKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 401
+++ Q++ QE+ ++E +L+ D D L+++ +A+R +++
Sbjct: 1127 AAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE 1186
Query: 402 LEEEAKSRAEEL----KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVT- 456
+E + + +E + L E K +EA L +S+ A + + S+ + ED
Sbjct: 1187 SQEGREVQRQEAGELRRSLGEGAKEREA-LRRSNEELRSAVKKAESERISLKLANEDKEQ 1245
Query: 457 --AQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLD 514
A E + E +L+ ++ +A + ++++ Q+ +S N R L +
Sbjct: 1246 KLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAE 1305
Query: 515 LQTKSALKETEIKEITVSFL-----------------QKITDLQNQLKQQEEDFRKQLED 557
LQ + AL E KE L Q++ Q +L++QE +FR +
Sbjct: 1306 LQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERR 1365
Query: 558 EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE------- 610
G E T + + L E + L+L A E Q L E
Sbjct: 1366 LLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQ 1425
Query: 611 HGAAQEQLNKIRDSYAKLLG 630
AA+ QL +R + + LG
Sbjct: 1426 RRAAEAQLGGLRSALRRGLG 1445
Score = 85.1 bits (209), Expect = 2e-16
Identities = 148/695 (21%), Positives = 299/695 (43%), Gaps = 108/695 (15%)
Query: 60 TTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 119
T+LPA R++ + + + + L E + LQE Q L+ EL ++E L
Sbjct: 45 TSLPALIREIVTRNLSQPE-SPVLLPATEMASLLSLQEEN------QLLQQELSRVEDLL 97
Query: 120 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMK-LRNKRE 178
+ E+ L+ + ++L + R L+ E + L S+EL + L+ ++
Sbjct: 98 AQSRAERDELAIKYNAVSERLEQALR----LEPGELETQEPRGLVRQSVELRRQLQEEQA 153
Query: 179 TKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL----L 234
+ R + A QEG + + Q+ QR QGKI Q + + +E++ ++ E E+
Sbjct: 154 SYRRKLQAYQEGQQRQAQLVQRL----QGKILQYKKRCSELEQQLLERSGELEQQRLRDT 209
Query: 235 EYIEEISCASDQVEKYK---LDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNV 291
E+ +++ A ++E+ + +AQ+ L+E+ D+ S Q+L E+I ++V +
Sbjct: 210 EHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDI----RKVTNDWT 265
Query: 292 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ----------------EREKL 335
+C+ KE E R E+ NA N + +L + ER+ L
Sbjct: 266 RCR---KELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLL 322
Query: 336 Q------------------------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEK 371
Q E + ++ L+++ L + L ++L ++++++EK
Sbjct: 323 QLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQL---RDKVLREK 379
Query: 372 NLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA-ELEKS 430
+L +++++ LD+ D L + + VK+LE++ + + K L EKL+ E+ L++
Sbjct: 380 DLAQQQMQSDLDKAD-LSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQ 438
Query: 431 SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASE---------IEDLKLENSSLQ 481
+A T+ LQ+ + Q+ V + ES L+ SE + L + +
Sbjct: 439 AALETEDGEGLQQTLRDLAQA---VLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSP 495
Query: 482 EKAAKAGKNAEDVQHQILA-TESSNQEYVRMLL---DLQTKSALKETEIKEITVSFLQK- 536
+ + G+ + A ++SS + L LQ + E + + L+K
Sbjct: 496 PRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQ 555
Query: 537 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQL- 595
++D +++ + EE ++ + +G E+ E+ + LL E N Q+
Sbjct: 556 LSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVA 615
Query: 596 --QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAK---------LLGHQNLKQKIKHVVKL 644
Q + E++ L AAQE+L + RD + + L++ + + +L
Sbjct: 616 QQQAEELRQEREKL----QAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQL 671
Query: 645 KDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKV 679
+ + S L E+ ++R L++ LQ E +V
Sbjct: 672 EGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706
Score = 78.6 bits (192), Expect = 2e-14
Identities = 124/617 (20%), Positives = 254/617 (41%), Gaps = 68/617 (11%)
Query: 87 LEKEIRVLLQ-ERGAQDRRIQDLETELEKMEARLNAA--LREKTSLSANNATLEKQLIEL 143
LEK+ + Q E +D+ +++ + ++M++ L+ A T L LEKQ +E
Sbjct: 357 LEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEK 416
Query: 144 TRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVT--QRS 201
+ N+ L K + + +LE ++T A E +Q++ +R+
Sbjct: 417 DQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGSERT 476
Query: 202 LEESQGKIAQLEGKLVSIEKEKIDE------KSETEKLLEYIEEISCASDQVEKYKLDIA 255
+ S G + L G+ + + ++ + K +L +
Sbjct: 477 ADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQ 536
Query: 256 QLEENLKEKNDEILSLKQSL---EENIVILSKQVEDLNVKCQLLEKEKED---HVNRNRE 309
+ + D + +L++ L E L +Q++ L K + ED V R R
Sbjct: 537 DMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRS 596
Query: 310 HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 369
NE L+ E NL + QQ+ E+L+Q+ +KL + QEE+ +
Sbjct: 597 ANELLSREKSNLAHSLQVAQQQAEELRQER------------------EKLQAAQEELRR 638
Query: 370 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 429
+++ EEE + + + +++++ E++ R ++QLE + A+EL + E L
Sbjct: 639 QRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREAL--------- 689
Query: 430 SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLEN-----SSLQEKA 484
S A Q +L EK + + + E ++T E+ L++ S+L E
Sbjct: 690 -SRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESL 748
Query: 485 AKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQL 544
A+ + + Q+ +S+ Q R T + ++ ++E+ + L+ L
Sbjct: 749 AQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSL 808
Query: 545 K---QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFE 601
+ Q +E +QL +++ + A+L+ +++ +EL + Q Q++A E
Sbjct: 809 RVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGRE---QELEQARREAQRQVEALE 865
Query: 602 ---VEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKL 658
EK+AL EH QL + + + + +L+ E L+ + ++
Sbjct: 866 RAAREKEALAKEHAGLAVQL---------VAAEREGRTLSEEATRLRLEKEALEGSLFEV 916
Query: 659 RCQLAKKKQSETKLQEE 675
+ QLA+ + +L+ E
Sbjct: 917 QRQLAQLEARREQLEAE 933
Score = 77.8 bits (190), Expect = 3e-14
Identities = 104/530 (19%), Positives = 229/530 (43%), Gaps = 25/530 (4%)
Query: 16 GCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESK 75
G A SP + D+ E ++G + + F Q+ S Q + T A R++ E++
Sbjct: 1492 GPATSPASPDLDP-EAVRGAL-----REFLQELRSAQRERDELRTQTSALNRQLAEMEAE 1545
Query: 76 ESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNAT 135
+ + L+K + + R + D R+ ++ EL E + + RE+ + AT
Sbjct: 1546 RDSATSR-ARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVAT 1604
Query: 136 LEKQLIELTRTNELLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMK 194
LE+ L + K S+ N+ L L ++ + E++ + ++ +E +
Sbjct: 1605 LERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGE 1664
Query: 195 LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 254
LQ ++ L + + + L+ ++ S++++ D + + L +E ++ A +VE+ + +
Sbjct: 1665 LQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL 1724
Query: 255 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE---DHVNRNREHN 311
L E + + S + + L K + Q+L++ + ++ R+ +
Sbjct: 1725 RDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQS 1784
Query: 312 ENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEK 371
+L ++Q L+ + + +R + + + Q+ +L+Q +E ++ + Q+ E+
Sbjct: 1785 SSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD----ER 1840
Query: 372 NLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL-KLLEEKLKGKE------ 424
L +E L L +L+ ++ + ER +LE++ + L K+ EKL+ E
Sbjct: 1841 RLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLS 1900
Query: 425 AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 484
AE + T A L L E +Q LE E + E+ D + + LQ++
Sbjct: 1901 AEKGRLDRTLTGAELELAEA-QRQIQQLEAQVVVLEQSHSPAQLEV-DAQQQQLELQQEV 1958
Query: 485 AKAGKNAEDVQHQILATESSNQEYVRMLLD-LQTKSALKETEIKEITVSF 533
+ + + A E ++++ VR L + + T + E++ + F
Sbjct: 1959 ERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 113 bits (283), Expect = 5e-25
Identities = 144/640 (22%), Positives = 276/640 (43%), Gaps = 95/640 (14%)
Query: 65 SARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALR 124
S K S E K K+ K+L+ + + + QE RR+ ++E L + E L A+
Sbjct: 440 SPAKTSSMEKKLLIKS-KELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASET 498
Query: 125 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 184
+++ L + AT + L R+ E + + S+ ++ +L+L+ ++ K++
Sbjct: 499 QRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDK------ALQLLHDIREQSRKLQ-- 550
Query: 185 MAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS 244
E+K Q Q +EE + + QLE LVS + +SE
Sbjct: 551 -------EIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE--------------- 588
Query: 245 DQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHV 304
+ + +L + + E ++L K + + +K +E +N + QL +E ++ +
Sbjct: 589 --LRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAK-LEKINAEQQLKIQELQEKL 645
Query: 305 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ 364
+ + + +QN++Q ++E EKLQ +E + S + +KL +
Sbjct: 646 EKAVKASTEATELLQNIRQAKERAERELEKLQNRE-----------DSSEGIRKKLVEAE 694
Query: 365 EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKE 424
E ++EK+ + Q L+ L+QKE+ E +K L+ + K + + LE ++ E
Sbjct: 695 E--LEEKHREAQVSAQHLEV--HLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHE 750
Query: 425 AELEKSSAAHTQATLLLQEK-----YDSMVQSLEDVTAQFESYKALTASE---------- 469
E AH + +L ++K DS ++SLE + L A+
Sbjct: 751 EE------AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKA 804
Query: 470 ----IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETE 525
I +L+ + L+ +A K ++ Q+ + LL+L+T+ E
Sbjct: 805 QEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLE 864
Query: 526 IKEITVSFLQKITDLQNQLKQQEEDF------RKQLEDE-EGRKAEKENTTAELTEEINK 578
+E + +++T+LQ L+++E R LE + K E E TTAE EEI
Sbjct: 865 HEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQA 924
Query: 579 WRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN--LKQ 636
+E+ Q + DA + + +EQLN++ + A+ L +QN L +
Sbjct: 925 LTAHRDEI-------QRKFDALRNSCTVITD----LEEQLNQLTEDNAE-LNNQNFYLSK 972
Query: 637 KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 676
++ DE QL+SEV LR ++ +++ T ++ +
Sbjct: 973 QLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTM 1012
Score = 109 bits (273), Expect = 8e-24
Identities = 151/682 (22%), Positives = 290/682 (42%), Gaps = 73/682 (10%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASA---RKVKSSESKESQKNDKDLKILEKEIRVLL 95
QK K + + L D T + + R ++ + + SQ++DK L++L +IR
Sbjct: 488 QKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH-DIRE-- 544
Query: 96 QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFS 155
Q R Q+ + Q+ + ++E+M +N + S + E +L E E K K +
Sbjct: 545 QSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAT 604
Query: 156 ENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGK 215
E ++ L+K +++ + ++ G AK E + + Q+ + L+E K + +
Sbjct: 605 ECQHK---------LLKAKDQGKPEV-GEYAKLEKINAEQQLKIQELQEKLEKAVKASTE 654
Query: 216 LVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---- 271
+ + K E+ LE ++ +S+ + K ++ +LEE +E L
Sbjct: 655 ATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHL 714
Query: 272 ---KQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 328
+Q EE I +L Q +K L +KE + N + H E + + + L ++ +
Sbjct: 715 KQKEQHYEEKIKVLDNQ-----IKKDLADKETLE--NMMQRHEEEAHEKGKILSEQKAMI 767
Query: 329 QQEREKLQQKELQIDSLLQQEK--ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD 386
K++ E +I L + K SS Q+ QEEM+ E + L+ +L+
Sbjct: 768 NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 827
Query: 387 KLQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKY 445
+K EEQ E++ Q +++ +LLE + + +E LE H + L L+ +
Sbjct: 828 AQNRKLEEQLEKISHQ------DHSDKNRLLELETRLREVSLE-----HEEQKLELKRQL 876
Query: 446 DSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSN 505
+ SL++ +Q + +A A+ L+ + L+E A+A + +I A +
Sbjct: 877 TELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEA-------EEEIQALTAHR 929
Query: 506 QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEK 565
E R L+ + ITDL+ QL Q ED +L ++ +++
Sbjct: 930 DEIQRKFDALRNSCTV---------------ITDLEEQLNQLTED-NAELNNQNFYLSKQ 973
Query: 566 ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 625
+ + +EI + R + L + ++QL + + +AL +EQ+ +
Sbjct: 974 LDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALN 1033
Query: 626 AKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHF 685
+LL + + + V L DE SQ + V +L+ L +KQS + + + + +
Sbjct: 1034 DELLEKERQWEAWRSV--LGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVEL 1091
Query: 686 DPSKAFHHESKENFALKTPLKE 707
A E AL+ LKE
Sbjct: 1092 ----AVKEHKAEILALQQALKE 1109
Score = 72.4 bits (176), Expect = 1e-12
Identities = 109/512 (21%), Positives = 222/512 (43%), Gaps = 71/512 (13%)
Query: 29 LEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILE 88
LE G + Q + +Q ++ + DK+ L R + S E QK +LK
Sbjct: 819 LETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQK--LELKRQL 876
Query: 89 KEIRVLLQERGAQDRRIQDLETELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTN 147
E+++ LQER +Q T L+ A L + LR+ KT L A E+++ LT
Sbjct: 877 TELQLSLQERESQ-------LTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHR 929
Query: 148 ELLKSKFSENGN--------QKNLRILSLELMKLRN------KRETKMRG-----MMAKQ 188
+ ++ KF N ++ L L+ + +L N K+ + G + +
Sbjct: 930 DEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRS 989
Query: 189 EGMEMKLQVTQRSLEESQGK--IAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI----SC 242
E ++ ++T+R ++ + K + L+ +E++ +D ++ ++LLE + S
Sbjct: 990 EVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSV 1049
Query: 243 ASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLE-KEKE 301
D+ +++ + +L+ L + Q + E S+QV +L VK E +
Sbjct: 1050 LGDEKSQFECRVRELQRMLDTEKQSRARADQRITE-----SRQVVELAVKEHKAEILALQ 1104
Query: 302 DHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLC 361
+ + E+L+ ++ +L++K + + LQQK L+ E+EL L ++
Sbjct: 1105 QALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQK-------LETERELKQRLLEEQA 1157
Query: 362 SFQEEMVKEKN---LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEE 418
Q++M +KN + L++ LD D L+ + E ++ + ++ E
Sbjct: 1158 KLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI---------QVLYSHE 1208
Query: 419 KLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS---EIEDLKL 475
K+K +E + + T+ LQ K D + + + ++ + AL + +LKL
Sbjct: 1209 KVK-----MEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKL 1263
Query: 476 ENSSLQEKAAKAGKNAEDVQHQILATESSNQE 507
+L+++ A+ + E +Q + S+ +E
Sbjct: 1264 ---ALEKEKARCAELEEALQKTRIELRSAREE 1292
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 113 bits (282), Expect = 7e-25
Identities = 146/675 (21%), Positives = 301/675 (44%), Gaps = 72/675 (10%)
Query: 51 KQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLET 110
K NL +K TL KS + +Q N++ E++ LL+++ + +L+
Sbjct: 577 KVNLVFEKIQTL-------KSRAAGSAQGNNQACNSTS-EVKDLLEQKSKLTIEVAELQR 628
Query: 111 ELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLEL 170
+L+ E+ + AN L Q E N L+ + E+ + + L
Sbjct: 629 QLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQ 688
Query: 171 MKL-RNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSE 229
+K+ R + +T++R + + M +L +RS + +G + + + ++ + K E
Sbjct: 689 VKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEE 748
Query: 230 TEKLLEYIE-EISCASDQVEKYKLDIAQLEENLKEKND-EILSLKQSLEENIVILSKQVE 287
E LL E E++ +++ Q + LKE+ D E+ +L++S+EE +K VE
Sbjct: 749 QEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEE----ATKNVE 804
Query: 288 DLNVKCQLLEKEK---EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 344
L + E+++ E V +E NE L + L+++ Q++ E L+ E +
Sbjct: 805 VLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKE 864
Query: 345 LLQQEKELSSSLHQKLCSF---QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 401
L++ + L + L ++E V + E EL+ L + Q+++Q L ++
Sbjct: 865 TLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQ---LSEK 921
Query: 402 LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTA---- 457
L+EE++ + E+L+ L+ +++ + L K+ LQ++ +V++ T
Sbjct: 922 LKEESEQK-EQLRRLKNEMENERWHLGKTIEK-------LQKEMADIVEASRTSTLELQN 973
Query: 458 QFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT 517
Q + YK E+ +++ + +A K+ A +Q ++ E ++Y R + T
Sbjct: 974 QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALT 1033
Query: 518 KSALKETEIKEITVSFLQK--ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 575
K L E +K++ K + D +++L +Q ED QLE E E+ N + L+E
Sbjct: 1034 KRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEME---LEEERNNSDLLSER 1090
Query: 576 INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY---------- 625
I++ R E+L N+ + E +K +L ++ + ++ + SY
Sbjct: 1091 ISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQ 1150
Query: 626 -----AKL---------------LGHQNLKQKIKHVV-KLKDENSQLKSEVSKLRCQLAK 664
A+L L ++ L++K+K +V ++ DE+ L + +L +L
Sbjct: 1151 MEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKA 1210
Query: 665 KKQSETKLQEELNKV 679
K+ + +EE++++
Sbjct: 1211 MKRQVEEAEEEIDRL 1225
Score = 105 bits (263), Expect = 1e-22
Identities = 154/676 (22%), Positives = 307/676 (45%), Gaps = 91/676 (13%)
Query: 31 VLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKESQKNDKDLKILE 88
V++ P +S++ ++ K + L + T P S K S ++ S N + L
Sbjct: 481 VIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLL 540
Query: 89 KEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNE 148
K + L Q+ + + Q L L++ + A + K +L + E +T
Sbjct: 541 KGQQELTQQTNEETAK-QILYNYLKEGSTDNDDATKRKVNL----------VFEKIQT-- 587
Query: 149 LLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAK-QEGMEMKLQVTQRSLEESQG 207
LKS+ + + N S +K ++++K+ +A+ Q ++++++ Q EE +
Sbjct: 588 -LKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERER 646
Query: 208 KIAQLEGKLVSIEKEKIDEKSETEKLLEY--------IEEISCASDQVEKYKLDIAQLEE 259
A LE +L S EK++E S ++ LE +EE+ + E+++ +I L++
Sbjct: 647 MRANLE-ELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQD 705
Query: 260 NLKEKNDEILSLKQS-------LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 312
L E +DE+ S K+S L E ++ + ++DL L+ KE+++ + R RE
Sbjct: 706 QLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL-----LIAKEEQEDLLRKRERE- 759
Query: 313 NLNAEMQNLKQKFILEQQEREKL-QQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEK 371
L A LK++ QE +KL +Q + ++ +L + +E + ++ + L S +++
Sbjct: 760 -LTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV-EVLASRSNTSEQDQ 817
Query: 372 NLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS 431
E +K +E +KLQ + E+ ER V QL+ + E LKG EA+ +++
Sbjct: 818 AGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI-----------EDLKGDEAKAKET- 865
Query: 432 AAHTQATLLLQEKYDSMVQSLED--VTAQFESYKALTA-----SEIEDLK--LENSSLQE 482
+KY+ ++ LE+ V A+ E +A++A +E+E + L ++ ++
Sbjct: 866 ----------LKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQ 915
Query: 483 KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN 542
K E Q + L + E R L + K E+ +I + +LQN
Sbjct: 916 KQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQK--EMADIVEASRTSTLELQN 973
Query: 543 QLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEV 602
QL + +E R++L AE + E T E K RL ++ ++ + + +L ++
Sbjct: 974 QLDEYKEKNRREL-------AEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQR 1026
Query: 603 EKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQL 662
+ L + ++ L +D +L +LK +VK Q++ +VS+L +L
Sbjct: 1027 AQDEALTKRQLLEQTL---KDLEYELEAKSHLKDDRSRLVK------QMEDKVSQLEMEL 1077
Query: 663 AKKKQSETKLQEELNK 678
+++ + L E +++
Sbjct: 1078 EEERNNSDLLSERISR 1093
Score = 100 bits (249), Expect = 5e-21
Identities = 134/554 (24%), Positives = 251/554 (45%), Gaps = 69/554 (12%)
Query: 74 SKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANN 133
+KE Q++ +L K R L +GA + + E++K++ + +A L+
Sbjct: 745 AKEEQED-----LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQ--------- 790
Query: 134 ATLEKQLIELTRTNELLKSKFSEN-----GNQKNLRILSLELMKLRNKRETKMRGMMAKQ 188
L + + E T+ E+L S+ + + G + +++L E KL+ + E R + Q
Sbjct: 791 -ALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQ 849
Query: 189 ------EGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISC 242
+G E K + T L++ +G+I QLE LV KE+ E + LE E+
Sbjct: 850 RQIEDLKGDEAKAKET---LKKYEGEIRQLEEALVHARKEE-KEAVSARRALE--NELEA 903
Query: 243 ASDQVEKYKLDIAQLEENLKEKNDE---ILSLKQSLE-------ENIVILSKQVEDLNVK 292
A + + + QL E LKE++++ + LK +E + I L K++ D+
Sbjct: 904 AQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEA 963
Query: 293 CQLLEKEKEDHVNRNREHNENLNAEMQN-LKQKFILEQQEREKLQQKELQIDSLLQQEKE 351
+ E ++ ++ +E N AEMQ LK+K + + E+ +L ++Q D + E+E
Sbjct: 964 SRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTL--EAEKSRLTAMKMQ-DEMRLMEEE 1020
Query: 352 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE 411
L +Q+ Q+E + ++ L E+ LK EL+ ++ RLVKQ+E++
Sbjct: 1021 LRD--YQRA---QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEM 1075
Query: 412 ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMV--QSLEDVTAQFESYKALTASE 469
EL EE+ + E+ S + Q L E Q LE E S
Sbjct: 1076 EL---EEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSR 1132
Query: 470 IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI 529
I + LE S +++K G + ++ +I E + R +LQ + E ++KE+
Sbjct: 1133 I--IHLEGSY---RSSKEGLVVQ-MEARIAELEDRLESEERDRANLQLSNRRLERKVKEL 1186
Query: 530 TVSFLQK---ITDLQNQLKQQEEDFRKQLEDEEGR----KAEKENTTAELTEEINKWRLL 582
+ + +TD ++QL + + ++Q+E+ E ++ K+ EL E+++ L
Sbjct: 1187 VMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHL 1246
Query: 583 YEELYNKTKPFQLQ 596
+L + K +L+
Sbjct: 1247 QGQLNSMKKDLRLK 1260
Score = 69.7 bits (169), Expect = 9e-12
Identities = 105/473 (22%), Positives = 200/473 (42%), Gaps = 54/473 (11%)
Query: 27 KTLEVLKGPVSFQKSQRFKQQKESKQN----LNVDKDTTLPASARKVKSSESKESQKNDK 82
+ +E LKG + K K + E +Q ++ K+ SAR+ +E + +Q N
Sbjct: 850 RQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLS 909
Query: 83 DLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIE 142
+K++ L+E Q +++ L+ E+E L + + A+ ++E
Sbjct: 910 QTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD-------IVE 962
Query: 143 LTRTNELLKSKFSENGNQKNLRILSLELMKLRNK-------RETKMRGMMAKQEGMEMKL 195
+RT+ L + +KN R L+ +L+ K R T M+ M + ME +L
Sbjct: 963 ASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMK-MQDEMRLMEEEL 1021
Query: 196 QVTQRSLEESQGKIAQLEGKLVSIEKE---KIDEKSETEKLLEYIEEISCASDQVEKYKL 252
+ QR+ +E+ K LE L +E E K K + +L++ +E+
Sbjct: 1022 RDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMED------------- 1068
Query: 253 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 312
++QLE L+E+ + L E I +Q+E QL + ++ R +
Sbjct: 1069 KVSQLEMELEEERNN----SDLLSERISRSREQME------QLRNELLQERAARQDLECD 1118
Query: 313 NLNAEMQN--LKQKFI-LEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 369
++ E QN LK + I LE R + +Q+++ + + ++ S + + Q +
Sbjct: 1119 KISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRR 1178
Query: 370 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 429
+ +E + Q DE L +++Q +K ++ + + EE+ LE K + ELE+
Sbjct: 1179 LERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEE 1238
Query: 430 SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 482
+ LQ + +SM + L + S + +DL + SL E
Sbjct: 1239 QMDMNEH----LQGQLNSMKKDLR--LKKLPSKVLDDMDDDDDLSTDGGSLYE 1285
Score = 47.4 bits (111), Expect = 5e-05
Identities = 42/215 (19%), Positives = 100/215 (46%), Gaps = 13/215 (6%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGA 100
S+R + +E + L + +AR+ + ++ +KDLK + I + R +
Sbjct: 1088 SERISRSREQMEQLR--NELLQERAARQDLECDKISLERQNKDLK--SRIIHLEGSYRSS 1143
Query: 101 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ 160
++ + +E + ++E RL + R++ +L +N LE+++ EL + ++ +Q
Sbjct: 1144 KEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQ 1203
Query: 161 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIE 220
+LR+ +++ + E + +E + QR LEE L+G+L S++
Sbjct: 1204 LSLRLKAMKRQVEEAEEEI---------DRLESSKKKLQRELEEQMDMNEHLQGQLNSMK 1254
Query: 221 KEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIA 255
K+ +K ++ L + ++ ++D Y+ ++
Sbjct: 1255 KDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPVS 1289
Score = 36.6 bits (83), Expect = 0.084
Identities = 54/241 (22%), Positives = 98/241 (40%), Gaps = 42/241 (17%)
Query: 474 KLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSF 533
KL+ ++ A + ++ ++L TE S + V L +S KE E+K T +
Sbjct: 446 KLQGAAHGASCAHSRPPQPNIDGKVLETEGSQESTVIRAPSLGAQSK-KEEEVKTATATL 504
Query: 534 LQKITDLQNQLKQQEEDF-RKQLEDEEGRKAEKENTTA-------ELTEEINKWRLLYEE 585
+ LQN+ D K++ + A T ELT++ N+ +
Sbjct: 505 M-----LQNRATATSPDSGAKKISVKTFPSASNTQATPDLLKGQQELTQQTNE-ETAKQI 558
Query: 586 LYNKTKPFQLQLDAFEVEKQALLNEH---------GAAQ----------------EQLNK 620
LYN K D K L+ E G+AQ EQ +K
Sbjct: 559 LYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDLLEQKSK 618
Query: 621 IRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 680
+ A+L + L+ ++K+ +K+E ++++ + +LR Q +K + + LQ+ L +
Sbjct: 619 LTIEVAEL--QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESE 676
Query: 681 G 681
G
Sbjct: 677 G 677
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 112 bits (279), Expect = 2e-24
Identities = 161/718 (22%), Positives = 312/718 (43%), Gaps = 101/718 (14%)
Query: 84 LKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL 143
+++ E+ R L E Q + + L LE+ME R+ +K +L+A + +++K L+E+
Sbjct: 256 IELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIET---QKQTLNARDESIKK-LLEM 311
Query: 144 TRTNELLKSKFSENGNQKNLRILSLE--------LMKLRNKRETKMRGMMAKQEGME--- 192
++ L SK E+ N++ R+ E ++ + K +R + ++ ++
Sbjct: 312 LQSKGL-PSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEP 370
Query: 193 MKLQVTQRSLEESQGKIAQLEGKLVSIEKE----KIDEKSETEKLLEYIEEISCASDQVE 248
K + Q +E KIA LE + +E E K + TE E I++I +
Sbjct: 371 AKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSK 430
Query: 249 KYKLDIAQLEENLKEKNDEILSLKQSLE----------ENIVILSKQVEDLNVKCQLLE- 297
K I QL++ L +K E+L+L+ LE ++I +L + + + +L+
Sbjct: 431 FMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQT 490
Query: 298 ---------KEKEDHVNRNREHNENLNAEMQNLK-----QKFILEQQERE--KLQQKELQ 341
+EKE +N+ + ++L E L K +LE +ER+ LQ+K
Sbjct: 491 EVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIEN 550
Query: 342 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK-EEQAERLVK 400
+ L+ + + ++L ++ S Q + L++ L E +++ ++ +EQ ER +
Sbjct: 551 LQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALAT-LEEALSEKERIIERLKEQRERDDR 609
Query: 401 QLEEEAKSRAEELKLLEEKLKGKEAEL-EKSSAA-----HTQATLLLQEKYDSMVQSLED 454
+ EE +S +E K L+EK+ +AEL EK S+ H + K DS ++SLE
Sbjct: 610 ERLEEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEI 669
Query: 455 VTAQFESY------KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEY 508
Q + + A IED N ++ + K A + + ++
Sbjct: 670 AIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRL 729
Query: 509 VRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENT 568
+ +L +++ + K+ +I E+ L+ + D ++ + + +QLE ++ + +E
Sbjct: 730 LEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVANLKHN--QQLEKKKNAQLLEEVR 787
Query: 569 TAELTEEINKWRLLYEELYNKTKPFQLQLDAFE----------VEKQA-LLNEHGAAQEQ 617
E + N L EEL N + + +LDA + EK+A L N ++Q
Sbjct: 788 RREDSMADNSQHLQIEELMNALEKTRQELDATKARLASTQQSLAEKEAHLANLRIERRKQ 847
Query: 618 LNKI--------------RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLA 663
L +I +D+ LL K+K K ++E LK E +L QL
Sbjct: 848 LEEILEMKQEALLAAISEKDANIALLELSASKKK-----KTQEEVMALKREKDRLVHQLK 902
Query: 664 KKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQE 721
++ Q+ KL + ++D +H + ++P + ++N +P + E
Sbjct: 903 QQTQNRMKLMAD--------NYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQDDE 952
Score = 94.0 bits (232), Expect = 4e-19
Identities = 140/665 (21%), Positives = 268/665 (40%), Gaps = 114/665 (17%)
Query: 62 LPASARKVKSSESKESQKNDKDLK----ILEKEIRVLLQERGAQDRRIQDL-------ET 110
+P+ R+V+ S + Q K+L+ +L KE+ + + G+ I+ E
Sbjct: 135 VPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKER 194
Query: 111 ELEKMEARLNAALREKTSLSANNATLEKQLIELT--------RTNELLKSKFSENGNQKN 162
L K EA + L+E+ +S E Q ++LT RT L + +
Sbjct: 195 VLRKEEAARMSVLKEQMRVSHE----ENQHLQLTIQALQDELRTQRDLNHLLQQESGNRG 250
Query: 163 LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE 222
++EL E R + A+ + +L + +++LEE + +I +K+
Sbjct: 251 AEHFTIELT------EENFRRLQAEHDRQAKELFLLRKTLEEMELRI--------ETQKQ 296
Query: 223 KIDEKSET-EKLLEYIEEISCASDQVE----------KYKLDIAQLEENLKEKNDEILSL 271
++ + E+ +KLLE ++ S +E + + ++ LE L +K E + L
Sbjct: 297 TLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHL 356
Query: 272 KQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN-ENLNAEMQNLKQKFILEQQ 330
++ L + Q E K E +D + E N +L E+Q LK +L +
Sbjct: 357 REELHRRSQL---QPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTE 413
Query: 331 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 390
+RE+ + K++++ K S + K+ ++E+ K+ E EL +L+ L
Sbjct: 414 DREE-EIKQIEV------YKSHSKFMKTKIDQLKQELSKK----ESELLALQTKLETLSN 462
Query: 391 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 450
+ ++ ++ L+E ++ + +L+ ++ LE+ + + T +
Sbjct: 463 QNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKT-----------K 511
Query: 451 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 510
L+D+T + K A EI D+K + K K E++Q Q+ +
Sbjct: 512 QLQDLTEE----KGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKD 567
Query: 511 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 570
+ LQT S+ +T + + + +K ++ +Q+E D R++LE+ E + E +
Sbjct: 568 RVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENK---- 623
Query: 571 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL-LNEHGAAQEQLNKIRDSYAKLL 629
+L E++N LQ + E E + L EH ++ RDS K
Sbjct: 624 DLKEKVN----------------ALQAELTEKESSLIDLKEHASSLASAGLKRDSKLK-- 665
Query: 630 GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSK 689
L+ Q K E SKL QL K E + IK D
Sbjct: 666 -------------SLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEA 712
Query: 690 AFHHE 694
+++ +
Sbjct: 713 SYYRD 717
Score = 67.4 bits (163), Expect = 4e-11
Identities = 91/426 (21%), Positives = 183/426 (42%), Gaps = 35/426 (8%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRI 105
++KES N K T + K + + E + L++ E++I VL ++ ++
Sbjct: 500 EEKESFLN----KKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQL 555
Query: 106 QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRI 165
+D + +L ++ R+ + + ++ ATLE+ L E R E LK + + + R+
Sbjct: 556 RDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRE---RL 612
Query: 166 LSLELMKLRNKR-ETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIE---K 221
+E + NK + K+ + A+ E L + + + KL S+E +
Sbjct: 613 EEIESFRKENKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIE 672
Query: 222 EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 281
+K +E S+ E L+ I S ++ I QL++ DE + ++ + I
Sbjct: 673 QKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEI 732
Query: 282 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 341
L + + N K +K+ + + H ++ N ++ NLK Q+ EK + +L
Sbjct: 733 LKEVENEKNDK----DKKIAELESLTLRHMKDQNKKVANLK-----HNQQLEKKKNAQLL 783
Query: 342 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 401
+ +++ +S H ++ EE++ +EL T L QQ + E +
Sbjct: 784 EEVRRREDSMADNSQHLQI----EELMNALEKTRQELDATKARLASTQQSLAEKEAHLAN 839
Query: 402 LEEEAKSRAEELKLLEEK-----LKGKEA-----ELEKSSAAHTQATLL-LQEKYDSMVQ 450
L E + + EE+ ++++ + K+A EL S TQ ++ L+ + D +V
Sbjct: 840 LRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVH 899
Query: 451 SLEDVT 456
L+ T
Sbjct: 900 QLKQQT 905
Score = 52.8 bits (125), Expect = 1e-06
Identities = 68/301 (22%), Positives = 139/301 (46%), Gaps = 47/301 (15%)
Query: 26 VKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL-PASARKVKSSESKESQKNDKDL 84
+K+LE+ + +K + K + + K+ N++ D+ + P A ++K + + S D+
Sbjct: 664 LKSLEIA---IEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECG 720
Query: 85 KILEKEIRVLLQ-------ERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLE 137
K + E+ LL+ E+ +D++I ELE + R +K + +N LE
Sbjct: 721 KA-QAEVDRLLEILKEVENEKNDKDKKI----AELESLTLRHMKDQNKKVANLKHNQQLE 775
Query: 138 K----QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEM 193
K QL+E R E S N ++L+I ELM K ++ + +
Sbjct: 776 KKKNAQLLEEVRRRE-----DSMADNSQHLQIE--ELMNALEKTRQEL-------DATKA 821
Query: 194 KLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLD 253
+L TQ+SL E + +A L +I+ + + E++LE +E A+ + +
Sbjct: 822 RLASTQQSLAEKEAHLANL----------RIERRKQLEEILEMKQEALLAAISEKDANIA 871
Query: 254 IAQLEENLKEK-NDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 312
+ +L + K+K +E+++LK+ + + L +Q + N + + +DH + + H+
Sbjct: 872 LLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQ--NRMKLMADNYDDDHHHYHHHHHH 929
Query: 313 N 313
+
Sbjct: 930 H 930
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 111 bits (278), Expect = 2e-24
Identities = 155/726 (21%), Positives = 307/726 (42%), Gaps = 93/726 (12%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEI------- 91
QK + ++K Q + +T L A A +++ + + Q+ ++ L +E +
Sbjct: 880 QKHSQLTEEKNLLQE-QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938
Query: 92 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELT 144
+ L ER +++ DLE +LE+ EA EK + A LE +++ +L+
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 145 RTNELLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLE 203
+ +LL+ + S+ N + L KL+NK E+ + +E++L+ ++S +
Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQ 1051
Query: 204 ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 263
E + +LEG ++ D +++ +L + + + E+ + +A+L++ + +
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQ 1105
Query: 264 KNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQ 323
KN+ + +++ LE +I L + ++ EK+K D E E L E+++
Sbjct: 1106 KNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRD----LGEELEALKTELEDTLD 1160
Query: 324 KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 383
+Q+ R K +Q+ + L +E + Q++ + V+E E+ K+
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 384 ELDKLQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 442
LDK +Q E++ L +L +++ +E++ ++KL+ + EL+ + +A L
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279
Query: 443 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 502
+K + +E VT + + KA K K+ + Q+ T+
Sbjct: 1280 DKVHKLQNEVESVTGML------------------NEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 503 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN------QLKQQEEDFRKQLE 556
QE R L++ TK E E + +++ QN L Q D +K+L+
Sbjct: 1322 ELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ 1381
Query: 557 D--------EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALL 608
D EEG+K + LT++ + Y++L Q +LD V+ L
Sbjct: 1382 DFASTVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD----L 1436
Query: 609 NEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQLKSEVSKLRCQ---LAK 664
+ L K + + +LL + N+ K DE + ++E + + LA+
Sbjct: 1437 DNQRQLVSNLEKKQRKFDQLLAEEKNISS------KYADERDRAEAEAREKETKALSLAR 1490
Query: 665 KKQSETKLQEEL---NKVLGIK-------HFDPSKAFHHESKENFALKTPLKEGNTNCYR 714
+ + +EEL NK+L + D K H K AL+T ++E T
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 715 APMECQ 720
E Q
Sbjct: 1551 LEDELQ 1556
Score = 110 bits (275), Expect = 5e-24
Identities = 140/662 (21%), Positives = 291/662 (43%), Gaps = 52/662 (7%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQER 98
Q ++ K++K ++ ++ D T L K K+ KN + I E E+R+ +E+
Sbjct: 993 QNNKLSKERKLLEERIS-DLTTNLAEEEEKAKNLTKL---KNKHESMISELEVRLKKEEK 1048
Query: 99 GAQD-----RRIQDLETELEKMEARLNAALRE-KTSLSANNATLEKQLI----ELTRTNE 148
Q+ R+++ ++ + A L A + E K L+ L+ L E+ + N
Sbjct: 1049 SRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNN 1108
Query: 149 LLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGK 208
LK G+ +L+ RNK E + R + + E ++ +L+ T S Q
Sbjct: 1109 ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168
Query: 209 IAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEI 268
A+ E + V++ K+ +DE++ + + QV++ + AQ E L E+ ++
Sbjct: 1169 RAKREQE-VTVLKKALDEETRSHEA------------QVQEMRQKHAQAVEELTEQLEQF 1215
Query: 269 LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 328
K +L++N L K+ DL + ++L + K++ ++ ++ L A++Q L+ K
Sbjct: 1216 KRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK----LEAQVQELQSKCSDG 1271
Query: 329 QQER-------EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 381
++ R KLQ + + +L + + + L + + S ++ + L +EE +Q
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 382 LDELDKLQQKEEQAERLVKQLEE--EAKSRAEE----LKLLEEKLKGKEAELEKSSAAHT 435
L+ KL+Q EE+ L QL+E EAK E L + K K + + A
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 436 QATLLLQEKYDSMVQSLEDVTAQF---ESYKALTASEIEDLKLENSSLQEKAAKAGKNAE 492
+ Q++ +++ Q E+ A + E K E++DL ++ + ++ + K
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 493 DVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFR 552
+ ++ + +Y + ++ KET+ + + L++ + + +L++ + +
Sbjct: 1452 KFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKMLK 1510
Query: 553 KQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 612
++ED K + EL + EE+ + + + +L A E K L
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570
Query: 613 AAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKL 672
A + Q RD A+ QN +++ + +L + ++L+ E + A KK+ E L
Sbjct: 1571 ALKGQFE--RDLQAR--DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626
Query: 673 QE 674
++
Sbjct: 1627 KD 1628
Score = 105 bits (261), Expect = 2e-22
Identities = 137/659 (20%), Positives = 292/659 (44%), Gaps = 89/659 (13%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKI---LEKEIRVLLQERGAQDR 103
Q+E++Q LNV R+++ + + D++++ LE+ I L + +
Sbjct: 1325 QEETRQKLNVS------TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKK 1378
Query: 104 RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN----GN 159
++QD + +E +E +E +L+ +L +T L+ + + N
Sbjct: 1379 KLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN 1438
Query: 160 QKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSI 219
Q+ L + +LE K++ K ++A+++ + K +R E++ + + E K +S+
Sbjct: 1439 QRQL-VSNLE------KKQRKFDQLLAEEKNISSKY-ADERDRAEAEAR--EKETKALSL 1488
Query: 220 EK---EKIDEKSETEK----LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 272
+ E ++ K E E+ L +E++ + D V K ++ + + L+ + +E+ +
Sbjct: 1489 ARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548
Query: 273 QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 332
+ LE+ + L V Q L+ + E + E NE ++Q ++ E ++
Sbjct: 1549 EELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Query: 333 EKLQ------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD 386
K + +K+L+ D L E + S++ + EE +K+ + ++K EL+
Sbjct: 1609 RKQRALAAAAKKKLEGD-LKDLELQADSAIKGR-----EEAIKQLRKLQAQMKDFQRELE 1662
Query: 387 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG-----KEAELEKSSAAHTQATLLL 441
+ ++ K+ E++AKS +L L+E L K+A+LEK A A+ L
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL- 1721
Query: 442 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 501
S +L+D + E+ A E+E+ + ++ ++ KA + AE + ++ LAT
Sbjct: 1722 -----SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE-LAT 1775
Query: 502 ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 561
E S QK + QL++Q ++ R +L + EG
Sbjct: 1776 ERST----------------------------AQKNESARQQLERQNKELRSKLHEMEGA 1807
Query: 562 -KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK 620
K++ ++T A L +I + L E++ + + Q + + +K L E E K
Sbjct: 1808 VKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVEDERK 1863
Query: 621 IRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 677
+ + Y + G+ +KQ + + + ++E+ ++ + KL+ +L + +S + E+N
Sbjct: 1864 MAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1922
Score = 86.3 bits (212), Expect = 9e-17
Identities = 119/536 (22%), Positives = 249/536 (46%), Gaps = 54/536 (10%)
Query: 171 MKLRN----KRETKMRGMMA---KQEGMEMK---LQVTQRSLEESQGKIAQLEGKLVSIE 220
+KLRN + TK++ ++ ++E M+ K LQ T+ ++++ ++ +LE K +
Sbjct: 827 LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT 886
Query: 221 KEK--IDE--KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND---EILSLKQ 273
+EK + E ++ETE E E + + ++ + + ++E L+E+ D ++ + ++
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 274 SLEENIVILSKQVEDLNVKCQLLEKEK-EDHVNRNREHNENLNAEMQNLKQKFILEQQER 332
+ + ++ L +Q+E+ Q L+ EK + +E L + QN K +ER
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-----SKER 1001
Query: 333 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK- 391
+ L+++ + + L +E+E + +L KL + E M+ E + ++ +++ EL+KL++K
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 392 EEQAERLVKQLEEEAKSRAE---ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 448
E A +Q+ + AE +L EE+L+ A L+ A A ++E +
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 449 VQSLEDVTAQ------FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 502
ED+ ++ E K E+E LK E + A Q ++ A
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA--------TQQELRAKR 1172
Query: 503 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 562
++ LD +T+S E +++E+ Q + +L QL+Q F++ + + K
Sbjct: 1173 EQEVTVLKKALDEETRS--HEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNK 1226
Query: 563 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ--EQLNK 620
E A+L E+ +E+ +K K + Q+ E++ + E A+ ++++K
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHK 1284
Query: 621 IRDSYAKLLGHQNLKQ--KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 674
+++ + G N + IK + +SQL+ L+ + +K TKL++
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Score = 80.1 bits (196), Expect = 7e-15
Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 32/336 (9%)
Query: 375 EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 434
EEE++ DEL K ++++++AE +K+LE++ EE LL+E+L +AE E + A
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAE 907
Query: 435 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 494
L +K Q LE++ + E + +E+ + LQ + K + D+
Sbjct: 908 EMRVRLAAKK-----QELEEILHEME-------ARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 495 QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 554
+ Q+ E++ Q+ LQ + E +IK++ L + D N+L ++ + ++
Sbjct: 956 EEQLEEEEAARQK-------LQLEKVTAEAKIKKLEDEIL-VMDDQNNKLSKERKLLEER 1007
Query: 555 LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAA 614
+ D AE+E LT+ NK + EL + K + E K+ L +
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 615 QEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TK 671
EQ+ ++ A+L Q K +L+ ++L E+++ L K ++ E +
Sbjct: 1068 HEQIADLQAQIAEL-----KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 672 LQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 707
LQE+L+ ++ K +E ALKT L++
Sbjct: 1123 LQEDLDSERAARN-KAEKQKRDLGEELEALKTELED 1157
Score = 79.0 bits (193), Expect = 1e-14
Identities = 105/509 (20%), Positives = 215/509 (42%), Gaps = 76/509 (14%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKES-QKNDKDLKI-----------L 87
S ++ +++ + +K+T + AR ++ + E+KE ++ +K LK +
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 88 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 147
K + L + + A + ++++++T+LE++E L A K L N L+ Q
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF------E 1577
Query: 148 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA----KQEG----MEMKLQVTQ 199
L+++ +N ++ L + + E K R + A K EG +E++
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 200 RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 259
+ EE+ ++ +L+ ++ ++E D ++ +++ +E + +E D+ QL+E
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQE 1694
Query: 260 NL-------KEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEKEDHVNRNRE 309
+L K+ + E L + L ++ L + L + LE+E E+
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 310 HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 369
++ + Q +Q ER Q+ E L +Q KEL S LH+ E VK
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE-----MEGAVK 1809
Query: 370 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 429
K K T+ L E + QLEE+ + A E + + LK K+ +L++
Sbjct: 1810 SK------FKSTIAAL----------EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 430 SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 489
+LLQ V+ + Q++ + ++ LK + +E++ +
Sbjct: 1854 ---------ILLQ------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 490 NAEDVQHQILATESSNQEYVRMLLDLQTK 518
N +Q ++ SN+ R + L++K
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 76.3 bits (186), Expect = 1e-13
Identities = 93/420 (22%), Positives = 192/420 (45%), Gaps = 50/420 (11%)
Query: 300 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 359
KED + + +E + E++ L+QK + E + L Q++LQ ++ L E E + +
Sbjct: 857 KEDELQKTKERQQKAENELKELEQKHS-QLTEEKNLLQEQLQAETELYAEAE---EMRVR 912
Query: 360 LCSFQEEMVKEKNLFEEELKQTLDELDKLQ-QKEEQAERLV---KQLEEEAKSRAEELKL 415
L + ++E+ + + E L++ D +LQ ++++ A++++ +QLEEE +R ++L+L
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQL 971
Query: 416 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF--ESYKALTASEIEDL 473
+ + K +LE L ++ + + + D+T E KA +++++
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN- 1030
Query: 474 KLEN--SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT-------KSALKET 524
K E+ S L+ + K K+ ++++ E ++ + DLQ + A KE
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 525 EIKEITVSFLQKITDLQNQLKQQEE------DFRKQLEDEEGRKAEKENTTAELTEEINK 578
E++ +I N LK+ E D ++ L+ E + + E +L EE+
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 579 WRLLYEELYNKTKPFQLQLDA-----FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 633
+ E+ + T Q +L A V K+AL E + + Q+ ++R +A+ + +
Sbjct: 1151 LKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV--EE 1207
Query: 634 LKQKIKHVVKLKDENSQLKSEVSKLRCQLA---------------KKKQSETKLQEELNK 678
L ++++ + K + K + K LA KKK+ E ++QE +K
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.315
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,212,860
Number of Sequences: 37866
Number of extensions: 1162862
Number of successful extensions: 33193
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 688
Number of HSP's successfully gapped in prelim test: 1473
Number of HSP's that attempted gapping in prelim test: 8587
Number of HSP's gapped (non-prelim): 9056
length of query: 724
length of database: 18,247,518
effective HSP length: 110
effective length of query: 614
effective length of database: 14,082,258
effective search space: 8646506412
effective search space used: 8646506412
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.