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Search of human proteins with 21614513
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
(902 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 1812 0.0
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 1412 0.0
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 471 e-132
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 464 e-130
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 459 e-129
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 458 e-128
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 453 e-127
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 433 e-121
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 413 e-115
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 345 1e-94
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 315 2e-85
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 277 4e-74
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 268 2e-71
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 246 5e-65
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 198 2e-50
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 173 7e-43
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 170 6e-42
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 127 6e-29
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 127 6e-29
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 127 6e-29
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 125 2e-28
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 125 2e-28
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 125 2e-28
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 123 9e-28
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 123 9e-28
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 113 9e-25
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 112 2e-24
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 112 2e-24
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 112 2e-24
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 110 8e-24
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 1812 bits (4693), Expect = 0.0
Identities = 902/902 (100%), Positives = 902/902 (100%)
Query: 1 MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWR 60
MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWR
Sbjct: 1 MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWR 60
Query: 61 AKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAIN 120
AKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAIN
Sbjct: 61 AKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAIN 120
Query: 121 WTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAV 180
WTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAV
Sbjct: 121 WTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAV 180
Query: 181 RLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQ 240
RLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQ
Sbjct: 181 RLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQ 240
Query: 241 KLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMI 300
KLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMI
Sbjct: 241 KLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMI 300
Query: 301 LASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRL 360
LASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRL
Sbjct: 301 LASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRL 360
Query: 361 VEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRM 420
VEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRM
Sbjct: 361 VEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRM 420
Query: 421 PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI 480
PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI
Sbjct: 421 PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI 480
Query: 481 SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI 540
SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI
Sbjct: 481 SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI 540
Query: 541 QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ 600
QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ
Sbjct: 541 QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ 600
Query: 601 VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK 660
VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK
Sbjct: 601 VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK 660
Query: 661 SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH 720
SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH
Sbjct: 661 SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH 720
Query: 721 DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP 780
DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP
Sbjct: 721 DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP 780
Query: 781 RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT 840
RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT
Sbjct: 781 RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT 840
Query: 841 RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF 900
RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF
Sbjct: 841 RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF 900
Query: 901 EY 902
EY
Sbjct: 901 EY 902
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 1412 bits (3654), Expect = 0.0
Identities = 669/902 (74%), Positives = 789/902 (87%), Gaps = 1/902 (0%)
Query: 1 MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWR 60
+K+A+IGQSLFGQEVY HLRKEGH VVGVFTVPDKDGKADPL L AEKDG PVFK +WR
Sbjct: 23 LKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGKADPLALAAEKDGTPVFKLPKWR 82
Query: 61 AKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAIN 120
KG+ + +V Y+++GAELNVLPFC+QFIPM+II +P+HGSIIYHPS+LPRHRGASAIN
Sbjct: 83 VKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASAIN 142
Query: 121 WTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAV 180
WTLI GDKK GFS+FWADDGLDTG +LLQ+ C+V P+DTV LYNRFLFPEGIK MV+AV
Sbjct: 143 WTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAV 202
Query: 181 RLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQ 240
+LIA+GKAPR+PQPEEGATYEGIQKKE A+I+WDQ AE +HNWIRG+DKVPGAWTE Q
Sbjct: 203 QLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQ 262
Query: 241 KLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMI 300
+TF+ STL S VP G+ L I GA +PG+VTK GL+LFGND K L V+N+Q EDGKMI
Sbjct: 263 MVTFYGSTLLNSS-VPPGEPLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMI 321
Query: 301 LASNFFKGAASSVLELTEAELVTAEAVRSVWQRILPKVLEVEDSTDFFKSGAASVDVVRL 360
AS +F +SV+ELT E+ AE ++ +W IL V +EDSTDFFKSGA+S+DV RL
Sbjct: 322 PASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVPIIEDSTDFFKSGASSMDVARL 381
Query: 361 VEEVKELCDGLELENEDVYMASTFGDFIQLLVRKLRGDDEEGECSIDYVEMAVNKRTVRM 420
VEE+++ C GL+L+NEDVYMA+ F FIQ +VRKLRG+D+E E +DY+ VN+ V+M
Sbjct: 382 VEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGEDQEVELVVDYISKEVNEIMVKM 441
Query: 421 PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI 480
P+Q FI G+F DA+ KT +TINPTDGS IC+VS A + DVDKAVAAAKDAFENG WG++
Sbjct: 442 PYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRM 501
Query: 481 SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI 540
+AR+RGRLMYRLADL+E++QEELATIEALD+GAVYTLALKTH+GMS+QTFRYFAGWCDKI
Sbjct: 502 NARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKI 561
Query: 541 QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ 600
QGSTIPINQARPNRNLT T+KEP+GVC IIIPWNYPLMML+WK+AACLAAGNT+V+KPAQ
Sbjct: 562 QGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQ 621
Query: 601 VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK 660
VTPLTALKFAEL++KAG PKGV+N++PGSG + GQRLS+HPD+RK+GFTGST +GK IMK
Sbjct: 622 VTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMK 681
Query: 661 SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH 720
SCA+SN+KKVSLELGGKSPLIIF DC+L+KAV+MGM +VFFNKGENCIAAGRLFVE+SIH
Sbjct: 682 SCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIH 741
Query: 721 DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP 780
DEFV RVVEE++KMK+G+PLDR TDHGPQNH AHL KL++YC+ GVKEGATLV GG QV
Sbjct: 742 DEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQ 801
Query: 781 RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT 840
RPGFF EPTVFTDVED+M++AKEESFGP+M+IS+F +GD+D VL RAN+TE+GLASGVFT
Sbjct: 802 RPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFT 861
Query: 841 RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF 900
RDINKA+YVS+KL+AGTVF+NTYNKTDVAAPFGG KQSGFGKDLGE ALNEYL+ KTVT
Sbjct: 862 RDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTL 921
Query: 901 EY 902
EY
Sbjct: 922 EY 923
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 471 bits (1213), Expect = e-132
Identities = 244/478 (51%), Positives = 318/478 (66%), Gaps = 7/478 (1%)
Query: 423 QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKIS 481
++FI E+ ++E + NP G +C+V A D+DKAV AA+ AF G W ++
Sbjct: 39 KIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMD 98
Query: 482 ARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQ 541
A +RGRL+ +LADL+E+ + LAT+E+L+ G + A + I+TFRY+AGW DKI
Sbjct: 99 ASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIH 158
Query: 542 GSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQV 601
G TIP++ T TR EP+GVCG IIPWN+PL+M +WK A L GNTVVIKPA+
Sbjct: 159 GMTIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQ 214
Query: 602 TPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
TPL+AL L +AG P GV+N+LPG G G ++ H + KI FTGSTEVGK I ++
Sbjct: 215 TPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEA 274
Query: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
SN+K+V+LELGGKSP IIFAD DL+ AV+ VFFN+G+ C A R+FVE+SI++
Sbjct: 275 AGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYE 334
Query: 722 EFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR 781
EFVRR VE ++ VG+P D T+ GPQ K++E Q GV EGA L CGG + R
Sbjct: 335 EFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGR 394
Query: 782 PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTR 841
GFF EPTVF++V D M IAKEE FGPV I RF +D V+ RAN ++FGL + VFT
Sbjct: 395 KGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFK--TMDEVIERANNSDFGLVAAVFTN 452
Query: 842 DINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVT 899
DINKAL VS +QAGTV++N YN + +PFGGFK SG G+++GE L EY VKTVT
Sbjct: 453 DINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 510
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 464 bits (1194), Expect = e-130
Identities = 242/478 (50%), Positives = 315/478 (65%), Gaps = 7/478 (1%)
Query: 423 QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKIS 481
++FI E+ D+ K NP +CQV DVDKAV AA+ AF+ G W +
Sbjct: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81
Query: 482 ARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQ 541
A +RGRL+Y+LADL+E+ + LAT+E+++ G +Y+ A + I+T RY AGW DKIQ
Sbjct: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141
Query: 542 GSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQV 601
G TIPI+ T TR EP+GVCG IIPWN+PL+ML WK L+ GNTVV+KPA+
Sbjct: 142 GRTIPID----GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQ 197
Query: 602 TPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
TPLTAL A L +AG P GVVN++PG G G +S H D+ K+ FTGSTEVGK I ++
Sbjct: 198 TPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEA 257
Query: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
SN+K+V+LELGGKSP I+ AD DL+ AV+ VF+++G+ CIAA R+FVE+SI+D
Sbjct: 258 AGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYD 317
Query: 722 EFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR 781
EFVRR VE +K +GNPL GPQ K+++ + G KEGA L CGG
Sbjct: 318 EFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGN 377
Query: 782 PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTR 841
G+F +PTVF++V D M IAKEE FGPV I +F LD V+ RAN T +GL++GVFT+
Sbjct: 378 KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFK--SLDDVIKRANNTFYGLSAGVFTK 435
Query: 842 DINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVT 899
DI+KA+ +S LQAGTV+VN Y PFGGFK SG G++LGE +EY VKTVT
Sbjct: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 459 bits (1182), Expect = e-129
Identities = 240/481 (49%), Positives = 317/481 (65%), Gaps = 7/481 (1%)
Query: 422 HQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKI 480
+QLFI E+ DA KT T+NPT G VI V+ DVD+AV AA++AF G W ++
Sbjct: 37 NQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRM 96
Query: 481 SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI 540
A +RGRL+ RLADL+E+ + LA++E LD G + + + I+ +RYFAGW DK
Sbjct: 97 DASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKW 156
Query: 541 QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ 600
G TIP++ ++ TR EPVGVCG IIPWN+PL+M WK A LA GNTVV+K A+
Sbjct: 157 HGKTIPMD----GQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAE 212
Query: 601 VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK 660
TPL+AL A L +AG P GVVN++ G G G ++ H DV K+ FTGSTEVG I K
Sbjct: 213 QTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQK 272
Query: 661 SCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIH 720
+ SN+K+V+LELGGKSP I+ AD D+ AV+ ++FFN G+ C A R FVE+SI+
Sbjct: 273 AAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIY 332
Query: 721 DEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP 780
+EF+ R VE+ ++ KVGNP + DT GPQ +++ Y Q G KEGA L+CGG +
Sbjct: 333 NEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFG 392
Query: 781 RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT 840
GFF +PTVF V+D M IAKEE FGPV + +F ++ V+ RAN T +GLA+ VFT
Sbjct: 393 ERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFK--KIEEVVERANNTRYGLAAAVFT 450
Query: 841 RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF 900
RD++KA+Y + LQAGTV+VNTYN PFGGFK+SG G++LGE L Y VKTVT
Sbjct: 451 RDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAYTEVKTVTI 510
Query: 901 E 901
+
Sbjct: 511 K 511
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 458 bits (1178), Expect = e-128
Identities = 233/480 (48%), Positives = 320/480 (66%), Gaps = 7/480 (1%)
Query: 423 QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKIS 481
++FI E+ +++ K T NP+ IC+V DVDKAV AA+ AF+ G W ++
Sbjct: 33 KIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLD 92
Query: 482 ARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQ 541
A RGRL+++LADL+E+ + LA +E +D G + A + I+T RYFAGW DKIQ
Sbjct: 93 ALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQ 152
Query: 542 GSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQV 601
G TIP + + + TR EP+GVCG I PWN+PL+ML WK A L GNT+V+KPA+
Sbjct: 153 GKTIPTD----DNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQ 208
Query: 602 TPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
TPLTAL L +AG P GVVN++PG G VG +S HP + KI FTGSTEVGK + ++
Sbjct: 209 TPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEA 268
Query: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
+ SN+K+V+LELGGK+P I+ AD DL+ AV+ VFFN+G+ C AA R+FVE+ ++
Sbjct: 269 ASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYS 328
Query: 722 EFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR 781
EFVRR VE +K VG+P D T+ GPQ K++E + G KEGA L CGG+ +
Sbjct: 329 EFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMED 388
Query: 782 PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTR 841
G F +PTVF++V D+M IAKEE FGPV I +F ++ V+ RAN+T++GL + VFT+
Sbjct: 389 KGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFK--SIEEVIKRANSTDYGLTAAVFTK 446
Query: 842 DINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFE 901
+++KAL ++ L++GTV++N YN APFGGFK SG G++LGE AL EY VKTVT +
Sbjct: 447 NLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIK 506
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 453 bits (1165), Expect = e-127
Identities = 237/489 (48%), Positives = 316/489 (64%), Gaps = 7/489 (1%)
Query: 412 AVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDA 471
A N++ +Q+FI E+ DA KT T+NP+ G VICQV+ DVDKAV AA+ A
Sbjct: 27 APNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAA 86
Query: 472 FENGR-WGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTF 530
F+ G W ++ A RGRL+ RLADL+E+ + LA +E LD G Y ++ + M ++
Sbjct: 87 FQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCL 146
Query: 531 RYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAA 590
RY+AGW DK G TIPI+ + TR EPVGVCG IIPWN+PL+M +WK LA
Sbjct: 147 RYYAGWADKYHGKTIPID----GDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALAT 202
Query: 591 GNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTG 650
GN VV+K A+ TPLTAL A L +AG P GVVN++PG G G ++ H DV K+ FTG
Sbjct: 203 GNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTG 262
Query: 651 STEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAA 710
STE+G+ I + SN+K+V+LELGGKSP II +D D++ AV+ ++FFN+G+ C A
Sbjct: 263 STEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAG 322
Query: 711 GRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGA 770
R FV++ I+DEFV R V + VGNP D T+ GPQ K++ Y G +EGA
Sbjct: 323 SRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQEGA 382
Query: 771 TLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANAT 830
L+CGG G+F +PTVF DV+D M IAKEE FGPVM I +F ++ V+ RAN +
Sbjct: 383 KLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFK--TIEEVVGRANNS 440
Query: 831 EFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALN 890
+GLA+ VFT+D++KA Y+S LQAGTV+VN Y+ +PFGG+K SG G++LGE L
Sbjct: 441 TYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGLQ 500
Query: 891 EYLRVKTVT 899
Y VKTVT
Sbjct: 501 AYTEVKTVT 509
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 433 bits (1114), Expect = e-121
Identities = 223/420 (53%), Positives = 286/420 (68%), Gaps = 6/420 (1%)
Query: 480 ISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDK 539
+ A +RGRL+ +LADL+E+ + LAT+E+L+ G + A + I+TFRY+AGW DK
Sbjct: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
Query: 540 IQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPA 599
I G TIP++ T TR EP+GVCG IIPWN+PL+M +WK A L GNTVVIKPA
Sbjct: 61 IHGMTIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 116
Query: 600 QVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIM 659
+ TPL+AL L +AG P GV+N+LPG G G ++ H + KI FTGSTEVGK I
Sbjct: 117 EQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQ 176
Query: 660 KSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSI 719
++ SN+K+V+LELGGKSP IIFAD DL+ AV+ VFFN+G+ C A R+FVE+SI
Sbjct: 177 EAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESI 236
Query: 720 HDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQV 779
++EFVRR VE ++ VG+P D T+ GPQ K++E Q GV EGA L CGG +
Sbjct: 237 YEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGL 296
Query: 780 PRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVF 839
R GFF EPTVF++V D M IAKEE FGPV I RF +D V+ RAN ++FGL + VF
Sbjct: 297 GRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFK--TMDEVIERANNSDFGLVAAVF 354
Query: 840 TRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVT 899
T DINKAL VS +QAGTV++N YN + +PFGGFK SG G+++GE L EY VKTVT
Sbjct: 355 TNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 414
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 413 bits (1061), Expect = e-115
Identities = 226/478 (47%), Positives = 296/478 (61%), Gaps = 45/478 (9%)
Query: 423 QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKIS 481
++FI E+ ++E + NP G +C+V A D+DKAV AA+ AF G W ++
Sbjct: 39 KIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMD 98
Query: 482 ARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQ 541
A +RGRL+ +LADL+E+ + LAT+E+L+ G + A + I+TFRY+AGW DKI
Sbjct: 99 ASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIH 158
Query: 542 GSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQV 601
G TIP++ T TR EP+GVCG IIPWN+PL+M +WK A L GNTVVIKPA+
Sbjct: 159 GMTIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQ 214
Query: 602 TPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
TPL+AL G+L+ EVGK I ++
Sbjct: 215 TPLSALYM--------------------GALI------------------KEVGKLIQEA 236
Query: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
SN+K+V+LELGGKSP IIFAD DL+ AV+ VFFN+G+ C A R+FVE+SI++
Sbjct: 237 AGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYE 296
Query: 722 EFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR 781
EFVRR VE ++ VG+P D T+ GPQ K++E Q GV EGA L CGG + R
Sbjct: 297 EFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGR 356
Query: 782 PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTR 841
GFF EPTVF++V D M IAKEE FGPV I RF +D V+ RAN ++FGL + VFT
Sbjct: 357 KGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFK--TMDEVIERANNSDFGLVAAVFTN 414
Query: 842 DINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVT 899
DINKAL VS +QAGTV++N YN + +PFGGFK SG G+++GE L EY VKTVT
Sbjct: 415 DINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 472
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 345 bits (885), Expect = 1e-94
Identities = 199/498 (39%), Positives = 291/498 (58%), Gaps = 19/498 (3%)
Query: 411 MAVNKRTVRMPHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKD 470
M+ V P G A+ + T + P G VI + + +V+ AV AK
Sbjct: 25 MSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKA 84
Query: 471 AFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTF 530
AF+ W + S +R R++ A ++ + ++E+AT+E ++ G A + + +S Q
Sbjct: 85 AFKI--WSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEA-RLDIDISWQCL 141
Query: 531 RYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAA 590
Y+AG + G I + P + TR+EP+GVC I WNYP + SWK+A LA
Sbjct: 142 EYYAGLAASMAGEHIQL----PGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALAC 197
Query: 591 GNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTG 650
GN +V KP+ TP++AL AE+ +AG+P G+ NV+ G G+ GQ L HPDV K+ FTG
Sbjct: 198 GNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG-GAATGQFLCQHPDVAKVSFTG 256
Query: 651 STEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAA 710
S G IM+ A +K V+LELGGKSPLIIF+DCD+N AV+ + + F +G+ C
Sbjct: 257 SVPTGMKIMEMSA-KGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNG 315
Query: 711 GRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGA 770
R+FV+ I D+F VV++ +++K+G+PL DT GP + HL +++ + + ++GA
Sbjct: 316 TRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGA 375
Query: 771 TLVCGGN-QVP-----RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDA-V 823
++CGG+ VP + G++ P V T+ D M KEE FGPVM I F D +A V
Sbjct: 376 KVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSF---DTEAEV 432
Query: 824 LSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKD 883
L RAN T FGLA+GVFTRDI +A V +LQAGT F+N YN + V PFGG+K+SGFG++
Sbjct: 433 LERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRE 492
Query: 884 LGEAALNEYLRVKTVTFE 901
G + Y ++KTV E
Sbjct: 493 NGRVTIEYYSQLKTVCVE 510
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 315 bits (806), Expect = 2e-85
Identities = 183/485 (37%), Positives = 281/485 (57%), Gaps = 17/485 (3%)
Query: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
FI G+F+ + ++ +P+ G V C+V + +++ AV AA++AF + W S ++
Sbjct: 13 FIDGKFLPC--SSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS--WSSRSPQE 68
Query: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
R R++ ++ADL+EQ EE A E+ D G LA + S+Q FR+FA T
Sbjct: 69 RSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFAS---SSLHHT 125
Query: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPL 604
Q + T + PVGV G+I PWN PL +L+WK A +AAGNTV+ KP+++T +
Sbjct: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Query: 605 TALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAI 664
TA +L KAG+P GVVN++ G+G VG+ L HP+V I FTGS + I + A
Sbjct: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
Query: 665 SNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFV 724
+ KK+SLELGGK+P IIF D +L++ + + S F N+GE C+ R+FV+ SI+ EF+
Sbjct: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFL 304
Query: 725 RRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGN----QVP 780
+R VE RK KVG P D G AHL K+ Y + + EGA + CG +P
Sbjct: 305 KRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLP 364
Query: 781 ---RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASG 837
+ G+F PTV TD++D EE FGPV + F D + + V+ RAN ++GLA+
Sbjct: 365 ARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPF-DSE-EEVIERANNVKYGLAAT 422
Query: 838 VFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKT 897
V++ ++ + V+ KLQ+G V+ N + ++ PFGG K SG G++ + + + + +KT
Sbjct: 423 VWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKT 482
Query: 898 VTFEY 902
+T ++
Sbjct: 483 ITVKH 487
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 277 bits (708), Expect = 4e-74
Identities = 176/480 (36%), Positives = 274/480 (57%), Gaps = 15/480 (3%)
Query: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
F+GG ++ A A T +P G+ + V+ V + AV AA +AF RW ++SA++
Sbjct: 64 FVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWREVSAKE 119
Query: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
R L+ + +LM Q++++LA I ++G A + S +F+ ++ G
Sbjct: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDI 178
Query: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPL 604
I A+ R L L K+P+GV +I PWN+P M++ K A LAAG TVV+KPA+ TP
Sbjct: 179 IH-TPAKDRRALVL--KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
Query: 605 TALKFAELTLKAGIPKGVVNVLPGS---GSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
+AL AEL +AGIP GV NV+P S VG+ + P V KI FTGST GK I+
Sbjct: 236 SALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK-ILLH 294
Query: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
A ++VK+VS+ELGG +P I+F ++++AV M+S F N G+ C+ + + V+ IHD
Sbjct: 295 HAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHD 354
Query: 722 EFVRRVVEEVRK-MKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVP 780
FV+ E ++K ++VGN + T GP + + K+ + V +GAT+V GG +
Sbjct: 355 AFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQ 414
Query: 781 RPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFT 840
FFEPT+ +V M EE+FGP+ + +F D + +A+ + ANA + GLA ++
Sbjct: 415 LGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKF-DTEEEAI-AIANAADVGLAGYFYS 472
Query: 841 RDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTF 900
+D + V+++L+ G V VN + V PFGG KQSG G++ + ++EYL +K V +
Sbjct: 473 QDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCY 532
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 268 bits (684), Expect = 2e-71
Identities = 176/493 (35%), Positives = 274/493 (55%), Gaps = 28/493 (5%)
Query: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
F+GG ++ A A T +P G+ + V+ V + AV AA +AF RW ++SA++
Sbjct: 64 FVGGRWLPA--AATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWREVSAKE 119
Query: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
R L+ + +LM Q++++LA I ++G A + S +F+ ++ G
Sbjct: 120 RSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWFSEEARRVYGDI 178
Query: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPL 604
I A+ R L L K+P+GV +I PWN+P M++ K A LAAG TVV+KPA+ TP
Sbjct: 179 IH-TPAKDRRALVL--KQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPF 235
Query: 605 TALKFAE-------------LTLKAGIPKGVVNVLPGS---GSLVGQRLSDHPDVRKIGF 648
+AL AE L +AGIP GV NV+P S VG+ + P V KI F
Sbjct: 236 SALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISF 295
Query: 649 TGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCI 708
TGST GK I+ A ++VK+VS+ELGG +P I+F ++++AV M+S F N G+ C+
Sbjct: 296 TGSTTTGK-ILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCV 354
Query: 709 AAGRLFVEDSIHDEFVRRVVEEVRK-MKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVK 767
+ + V+ IHD FV+ E ++K ++VGN + T GP + + K+ + V
Sbjct: 355 CSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVS 414
Query: 768 EGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRA 827
+GAT+V GG + FFEPT+ +V M EE+FGP+ + +F D + +A+ + A
Sbjct: 415 KGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKF-DTEEEAI-AIA 472
Query: 828 NATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEA 887
NA + GLA +++D + V+++L+ G V VN + V PFGG KQSG G++ +
Sbjct: 473 NAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKY 532
Query: 888 ALNEYLRVKTVTF 900
++EYL +K V +
Sbjct: 533 GIDEYLELKYVCY 545
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 246 bits (629), Expect = 5e-65
Identities = 158/478 (33%), Positives = 254/478 (53%), Gaps = 57/478 (11%)
Query: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
FI G+F+ + ++ +P+ G V C+V + +++ AV AA++AF + W S ++
Sbjct: 13 FIDGKFLPC--SSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS--WSSRSPQE 68
Query: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
R R++ ++ADL+EQ EE A E+ D G LA + S+Q FR+FA T
Sbjct: 69 RSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFAS---SSLHHT 125
Query: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPL 604
Q + T + PVGV G+I PWN PL +L+WK A +AAGNTV+ KP+++T +
Sbjct: 126 SECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSV 185
Query: 605 TALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAI 664
TA +L KAG+P GVVN++ G+G VG+ L HP+V I FTGS + I + A
Sbjct: 186 TAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA- 244
Query: 665 SNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFV 724
+ KK+SLELGGK+P IIF D +L++ + + S F N+ + +V
Sbjct: 245 PHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQVRS----------------YV 288
Query: 725 RRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGF 784
+R + E ++ G +D+ + P + A G+
Sbjct: 289 KRALAEGAQIWCGEGVDKLS--LPARNQA-----------------------------GY 317
Query: 785 FFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDIN 844
F PTV TD++D EE FGPV + F D + + V+ RAN ++GLA+ V++ ++
Sbjct: 318 FMLPTVITDIKDESCCMTEEIFGPVTCVVPF-DSE-EEVIERANNVKYGLAATVWSSNVG 375
Query: 845 KALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFEY 902
+ V+ KLQ+G V+ N + ++ PFGG K SG G++ + + + + +KT+T ++
Sbjct: 376 RVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH 433
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 198 bits (503), Expect = 2e-50
Identities = 132/469 (28%), Positives = 231/469 (49%), Gaps = 17/469 (3%)
Query: 441 TINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQ 500
T P + I +V A V D ++ V A++A++ W I A RG ++ ++ D + +
Sbjct: 68 TYCPANNEPIARVRQASVADYEETVKKAREAWKI--WADIPAPKRGEIVRQIGDALREKI 125
Query: 501 EELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTR 560
+ L ++ +L+ G + + V + Y G I G +P ++ + + +
Sbjct: 126 QVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPILPSERSG---HALIEQ 181
Query: 561 KEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKA---- 616
PVG+ GII +N+P+ + W A + GN + K A T L ++ ++ K
Sbjct: 182 WNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDN 241
Query: 617 GIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGG 676
+P + ++ G G+ +G ++ V + FTGST+VGK + + LELGG
Sbjct: 242 KLPGAICSLTCG-GADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQ-ERFGRSLLELGG 299
Query: 677 KSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKV 736
+ +I F D DL+ V + + G+ C A RLF+ +SIHDE V R+ + +++V
Sbjct: 300 NNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRV 359
Query: 737 GNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVED 796
GNP D + +GP + + + + KEG T+V GG + RPG + EPT+ T +
Sbjct: 360 GNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGH 419
Query: 797 HMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKAL-YVSDK-LQ 854
IA E+F P++ + +F + + V + N + GL+S +FT+D+ + ++ K
Sbjct: 420 DASIAHTETFAPILYVFKFKNE--EEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSD 477
Query: 855 AGTVFVN-TYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVTFEY 902
G V VN + ++ FGG K +G G++ G A +Y+R T T Y
Sbjct: 478 CGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINY 526
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 173 bits (438), Expect = 7e-43
Identities = 126/490 (25%), Positives = 231/490 (47%), Gaps = 24/490 (4%)
Query: 423 QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISA 482
+LFIGG+FV+++ K + NP VI +V A ++D A+A+ K AF W S
Sbjct: 41 KLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFP--AWADTSV 98
Query: 483 RDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQG 542
R +++ R L++++ +E+A + L+ G A + V +Q + + G
Sbjct: 99 LSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADA-EGDVFRGLQVVEHACSVTSLMMG 157
Query: 543 STIPINQARPNRNLTL-TRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQV 601
T+P +++ L + + P+GVC I P+N+P M+ W + GNT ++KP++
Sbjct: 158 ETMP----SITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSER 213
Query: 602 TPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
P + A+L +G P G +N++ G V + DHPD++ I F GS + G++I +
Sbjct: 214 VPGATMLLAKLLQDSGAPDGTLNIIHGQHEAV-NFICDHPDIKAISFVGSNKAGEYIFER 272
Query: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
+ K+V +G K+ ++ D + + + + F G+ C+A +
Sbjct: 273 -GSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA-K 330
Query: 722 EFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR 781
+++ +VE + ++V D GP ++ G KEGA+++ G ++
Sbjct: 331 KWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKV 390
Query: 782 PGF----FFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASG 837
G+ F PT+ ++V+ +M KEE FGPV+++ LD + N +G +
Sbjct: 391 KGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVV--LETETLDEAIQIVNNNPYGNGTA 448
Query: 838 VFTRDINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGF--KQSGFGKD---LGEAALNEY 892
+FT + A + + G V VN V P F +S F D G+ + Y
Sbjct: 449 IFTTNGATARKYAHLVDVGQVGVNV--PIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFY 506
Query: 893 LRVKTVTFEY 902
++KT+T ++
Sbjct: 507 TQLKTITSQW 516
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 170 bits (430), Expect = 6e-42
Identities = 138/472 (29%), Positives = 231/472 (48%), Gaps = 30/472 (6%)
Query: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
++ G+++ E + +P G + AQ DV AV AA+ AF+ W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKG--WSAHPGVV 100
Query: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
R + + RLA+++++HQ L T+E+L G V ++ Q Y A IQ ST
Sbjct: 101 RAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAST 155
Query: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVV--IKPAQVT 602
+ L EP+GV G+I+P + + + W+ LA G TVV + PA
Sbjct: 156 ---------QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPA 206
Query: 603 PLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSC 662
PL A+L + G G++NVL G SLV L+ P +RK+ F G+ E G+ + +S
Sbjct: 207 PLL---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSL 262
Query: 663 AISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDE 722
A ++ L LG +S L++ D++ AV+ + + + ++G + RL +++S+ DE
Sbjct: 263 A-GECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGL---RLLIQESVWDE 318
Query: 723 FVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRP 782
+RR+ E + +++ G LD D G + A + + + + +GA + G+ VP
Sbjct: 319 AMRRLQERMGRLRSGRGLDGAVDMGARGAAACDL-VQRFVREAQSQGAQVFQAGD-VPSE 376
Query: 783 GFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRD 842
F+ PT+ +++ A+ E PV++ S F L AN T G ++ V++
Sbjct: 377 RPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAK--EALLVANGTPRGGSASVWSER 434
Query: 843 INKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLR 894
+ +AL + LQ GTV++N + D + P GG K+SG G L EYLR
Sbjct: 435 LGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLR 486
Score = 94.0 bits (232), Expect = 6e-19
Identities = 76/250 (30%), Positives = 122/250 (48%), Gaps = 11/250 (4%)
Query: 421 PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI 480
P+ LF+GG F A GA++S I + G++ V+ D+ AV AA AF W
Sbjct: 527 PYGLFVGGRF-QAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPG--WAGQ 583
Query: 481 SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI 540
S R L++ LA +E+ + LA+ L+ A + V +S + R + G +
Sbjct: 584 SPGARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQA 640
Query: 541 QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ 600
QG T+ Q R L +EP+GV ++ P +PL+ A LA GNTVV+ P+
Sbjct: 641 QGHTL---QVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSA 697
Query: 601 VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK 660
PL AL+ + + P G+ NV+ G + + L+ H DV+ + + GS + G ++
Sbjct: 698 ACPLLALEVCQ-DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQ-GSQFVE 755
Query: 661 SCAISNVKKV 670
+ N+K V
Sbjct: 756 WASAGNLKPV 765
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 127 bits (318), Expect = 6e-29
Identities = 112/446 (25%), Positives = 194/446 (43%), Gaps = 19/446 (4%)
Query: 447 GSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLME-QHQEELAT 505
G + + A + ++KA+ AA A + W DR ++ + AD++ + E+
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARKE--WDLKPIADRAQIFLKAADMLSGPRRAEILA 145
Query: 506 IEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVG 565
+ G A I FR+ A + +++G PI+ P+ N T+ R G
Sbjct: 146 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PIS-VPPSTNSTVYRGLE-G 202
Query: 566 VCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNV 625
I P+N+ + + A L GN V+ KP+ L + + +AG+P ++
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 626 LPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCA-----ISNVKKVSLELGGKSPL 680
+P G L G ++ + I FTGS KH+ K A +++ E GGK+
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 681 IIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPL 740
+ D+ V + S F G+ C A RL+V S+ + R++EE ++KVG+P
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 741 -DRDTDHGPQNHHAHLVKLMEYCQHG-VKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHM 798
D T ++ ++ +H T++ GG G+F EP + +
Sbjct: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
Query: 799 FIAKEESFGPVMIISRFADGDLDAVLSRANA-TEFGLASGVFTRDINKALYVSDKLQ--A 855
I KEE FGPV+ + + D L ++ T +GL VF++D + + L+ A
Sbjct: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAA 501
Query: 856 GTVFVNTYNKTDVAA--PFGGFKQSG 879
G ++N + + PFGG + SG
Sbjct: 502 GNFYINDKSTGSIVGQQPFGGARASG 527
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 127 bits (318), Expect = 6e-29
Identities = 112/446 (25%), Positives = 194/446 (43%), Gaps = 19/446 (4%)
Query: 447 GSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLME-QHQEELAT 505
G + + A + ++KA+ AA A + W DR ++ + AD++ + E+
Sbjct: 28 GHKVAKFCYADKSLLNKAIEAALAARKE--WDLKPIADRAQIFLKAADMLSGPRRAEILA 85
Query: 506 IEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVG 565
+ G A I FR+ A + +++G PI+ P+ N T+ R G
Sbjct: 86 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PIS-VPPSTNSTVYRGLE-G 142
Query: 566 VCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNV 625
I P+N+ + + A L GN V+ KP+ L + + +AG+P ++
Sbjct: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
Query: 626 LPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCA-----ISNVKKVSLELGGKSPL 680
+P G L G ++ + I FTGS KH+ K A +++ E GGK+
Sbjct: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
Query: 681 IIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPL 740
+ D+ V + S F G+ C A RL+V S+ + R++EE ++KVG+P
Sbjct: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
Query: 741 -DRDTDHGPQNHHAHLVKLMEYCQHG-VKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHM 798
D T ++ ++ +H T++ GG G+F EP + +
Sbjct: 322 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 381
Query: 799 FIAKEESFGPVMIISRFADGDLDAVLSRANA-TEFGLASGVFTRDINKALYVSDKLQ--A 855
I KEE FGPV+ + + D L ++ T +GL VF++D + + L+ A
Sbjct: 382 PIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAA 441
Query: 856 GTVFVNTYNKTDVAA--PFGGFKQSG 879
G ++N + + PFGG + SG
Sbjct: 442 GNFYINDKSTGSIVGQQPFGGARASG 467
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 127 bits (318), Expect = 6e-29
Identities = 112/446 (25%), Positives = 194/446 (43%), Gaps = 19/446 (4%)
Query: 447 GSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLME-QHQEELAT 505
G + + A + ++KA+ AA A + W DR ++ + AD++ + E+
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARKE--WDLKPIADRAQIFLKAADMLSGPRRAEILA 145
Query: 506 IEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVG 565
+ G A I FR+ A + +++G PI+ P+ N T+ R G
Sbjct: 146 KTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQ-PIS-VPPSTNSTVYRGLE-G 202
Query: 566 VCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNV 625
I P+N+ + + A L GN V+ KP+ L + + +AG+P ++
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 626 LPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCA-----ISNVKKVSLELGGKSPL 680
+P G L G ++ + I FTGS KH+ K A +++ E GGK+
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 681 IIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPL 740
+ D+ V + S F G+ C A RL+V S+ + R++EE ++KVG+P
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 741 -DRDTDHGPQNHHAHLVKLMEYCQHG-VKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHM 798
D T ++ ++ +H T++ GG G+F EP + +
Sbjct: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
Query: 799 FIAKEESFGPVMIISRFADGDLDAVLSRANA-TEFGLASGVFTRDINKALYVSDKLQ--A 855
I KEE FGPV+ + + D L ++ T +GL VF++D + + L+ A
Sbjct: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAA 501
Query: 856 GTVFVNTYNKTDVAA--PFGGFKQSG 879
G ++N + + PFGG + SG
Sbjct: 502 GNFYINDKSTGSIVGQQPFGGARASG 527
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 125 bits (313), Expect = 2e-28
Identities = 113/437 (25%), Positives = 196/437 (44%), Gaps = 17/437 (3%)
Query: 458 VTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTL 517
++ + +AV A+ AF +GR + R + + L L+++ ++EL A D
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58
Query: 518 ALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPL 577
A V ++ Y + + ++ EP+GV +I WNYP
Sbjct: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118
Query: 578 MMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRL 637
+ +AAGN+VV+KP++++ A A + + + K + V+ G + L
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177
Query: 638 SDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMS 697
+ D I +TGST VGK IM + A ++ V+LELGGKSP + +CDL+ A +
Sbjct: 178 KERFD--HILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234
Query: 698 SVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVK 757
F N G+ C+A + + SI ++ V ++ + +++ G + D+G H +
Sbjct: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293
Query: 758 LMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFAD 817
+M G+ EG + GG + PT+ TDV+ + +EE FGPV+ I
Sbjct: 294 VM-----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPI--VCV 345
Query: 818 GDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVN--TYNKTDVAAPFGGF 875
L+ + N E LA +F+ + + + +G V N + T + PFGG
Sbjct: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405
Query: 876 KQSGFGKDLGEAALNEY 892
SG G G+ + +
Sbjct: 406 GNSGMGSYHGKKSFETF 422
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 125 bits (313), Expect = 2e-28
Identities = 113/437 (25%), Positives = 196/437 (44%), Gaps = 17/437 (3%)
Query: 458 VTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTL 517
++ + +AV A+ AF +GR + R + + L L+++ ++EL A D
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58
Query: 518 ALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPL 577
A V ++ Y + + ++ EP+GV +I WNYP
Sbjct: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118
Query: 578 MMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRL 637
+ +AAGN+VV+KP++++ A A + + + K + V+ G + L
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177
Query: 638 SDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMS 697
+ D I +TGST VGK IM + A ++ V+LELGGKSP + +CDL+ A +
Sbjct: 178 KERFD--HILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234
Query: 698 SVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVK 757
F N G+ C+A + + SI ++ V ++ + +++ G + D+G H +
Sbjct: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293
Query: 758 LMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFAD 817
+M G+ EG + GG + PT+ TDV+ + +EE FGPV+ I
Sbjct: 294 VM-----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPI--VCV 345
Query: 818 GDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVN--TYNKTDVAAPFGGF 875
L+ + N E LA +F+ + + + +G V N + T + PFGG
Sbjct: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405
Query: 876 KQSGFGKDLGEAALNEY 892
SG G G+ + +
Sbjct: 406 GNSGMGSYHGKKSFETF 422
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 125 bits (313), Expect = 2e-28
Identities = 113/437 (25%), Positives = 196/437 (44%), Gaps = 17/437 (3%)
Query: 458 VTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTL 517
++ + +AV A+ AF +GR + R + + L L+++ ++EL A D
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58
Query: 518 ALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPL 577
A V ++ Y + + ++ EP+GV +I WNYP
Sbjct: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118
Query: 578 MMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRL 637
+ +AAGN+VV+KP++++ A A + + + K + V+ G + L
Sbjct: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177
Query: 638 SDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMS 697
+ D I +TGST VGK IM + A ++ V+LELGGKSP + +CDL+ A +
Sbjct: 178 KERFD--HILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234
Query: 698 SVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVK 757
F N G+ C+A + + SI ++ V ++ + +++ G + D+G H +
Sbjct: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293
Query: 758 LMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFAD 817
+M G+ EG + GG + PT+ TDV+ + +EE FGPV+ I
Sbjct: 294 VM-----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPI--VCV 345
Query: 818 GDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVN--TYNKTDVAAPFGGF 875
L+ + N E LA +F+ + + + +G V N + T + PFGG
Sbjct: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405
Query: 876 KQSGFGKDLGEAALNEY 892
SG G G+ + +
Sbjct: 406 GNSGMGSYHGKKSFETF 422
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 123 bits (308), Expect = 9e-28
Identities = 98/333 (29%), Positives = 164/333 (49%), Gaps = 15/333 (4%)
Query: 562 EPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKG 621
+P+GV II WNYP ++ +AAGN V+IKP++++ TA A+L L + +
Sbjct: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQD 158
Query: 622 VVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLI 681
+ V+ G + L D I +TG+T VGK +M++ A ++ V+LELGGKSP
Sbjct: 159 LYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGKSPCY 215
Query: 682 IFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLD 741
I DCDL+ + + N G+ CIA + E S+ ++ V ++ E V++ G +
Sbjct: 216 IDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIK 274
Query: 742 RDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIA 801
D+ + H +++ + EG + GG + + PTV TDV+ +
Sbjct: 275 ESPDYERIINLRHFKRIL-----SLLEGQKIAFGG-ETDEATRYIAPTVLTDVDPKTKVM 328
Query: 802 KEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVN 861
+EE FGP++ I ++D ++ N E LA VF+ + + D+ +G V N
Sbjct: 329 QEEIFGPILPIVPVK--NVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGN 386
Query: 862 --TYNKTDVAAPFGGFKQSGFGKDLGEAALNEY 892
+ T + PFGG SG G G+ + + +
Sbjct: 387 DVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 123 bits (308), Expect = 9e-28
Identities = 98/333 (29%), Positives = 164/333 (49%), Gaps = 15/333 (4%)
Query: 562 EPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKG 621
+P+GV II WNYP ++ +AAGN V+IKP++++ TA A+L L + +
Sbjct: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKL-LPQYLDQD 158
Query: 622 VVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLI 681
+ V+ G + L D I +TG+T VGK +M++ A ++ V+LELGGKSP
Sbjct: 159 LYIVINGGVEETTELLKQRFD--HIFYTGNTAVGKIVMEAAA-KHLTPVTLELGGKSPCY 215
Query: 682 IFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLD 741
I DCDL+ + + N G+ CIA + E S+ ++ V ++ E V++ G +
Sbjct: 216 IDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEF-YGENIK 274
Query: 742 RDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIA 801
D+ + H +++ + EG + GG + + PTV TDV+ +
Sbjct: 275 ESPDYERIINLRHFKRIL-----SLLEGQKIAFGG-ETDEATRYIAPTVLTDVDPKTKVM 328
Query: 802 KEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVN 861
+EE FGP++ I ++D ++ N E LA VF+ + + D+ +G V N
Sbjct: 329 QEEIFGPILPIVPVK--NVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGN 386
Query: 862 --TYNKTDVAAPFGGFKQSGFGKDLGEAALNEY 892
+ T + PFGG SG G G+ + + +
Sbjct: 387 DVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTF 419
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 113 bits (282), Expect = 9e-25
Identities = 124/472 (26%), Positives = 197/472 (41%), Gaps = 81/472 (17%)
Query: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
++ G+++ E + +P G + AQ DV AV AA+ AF+ W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKG--WSAHPGVV 100
Query: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
R + + RLA+++++HQ L T+E+L G V ++ Q Y A IQ ST
Sbjct: 101 RAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAST 155
Query: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVV--IKPAQVT 602
+ L EP+GV G+I+P + + + W+ LA G TVV + PA
Sbjct: 156 ---------QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPA 206
Query: 603 PLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSC 662
P L A+L G + PG
Sbjct: 207 P---LLLAQLA-------GELGPFPG---------------------------------- 222
Query: 663 AISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDE 722
I NV L G + L+ A Q G+ V F RL +++S+ DE
Sbjct: 223 -ILNV------LSGPASLVPIL------ASQPGIRKVAFCGAPE--GGLRLLIQESVWDE 267
Query: 723 FVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRP 782
+RR+ E + +++ G LD D G + A + + + + +GA + G+ VP
Sbjct: 268 AMRRLQERMGRLRSGRGLDGAVDMGARGAAACDL-VQRFVREAQSQGAQVFQAGD-VPSE 325
Query: 783 GFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRD 842
F+ PT+ +++ A+ E PV++ S F L AN T G ++ V++
Sbjct: 326 RPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAK--EALLVANGTPRGGSASVWSER 383
Query: 843 INKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLR 894
+ +AL + LQ GTV++N + D + P GG K+SG G L EYLR
Sbjct: 384 LGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLR 435
Score = 94.0 bits (232), Expect = 6e-19
Identities = 76/250 (30%), Positives = 122/250 (48%), Gaps = 11/250 (4%)
Query: 421 PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI 480
P+ LF+GG F A GA++S I + G++ V+ D+ AV AA AF W
Sbjct: 476 PYGLFVGGRF-QAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPG--WAGQ 532
Query: 481 SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI 540
S R L++ LA +E+ + LA+ L+ A + V +S + R + G +
Sbjct: 533 SPGARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQA 589
Query: 541 QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ 600
QG T+ Q R L +EP+GV ++ P +PL+ A LA GNTVV+ P+
Sbjct: 590 QGHTL---QVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSA 646
Query: 601 VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK 660
PL AL+ + + P G+ NV+ G + + L+ H DV+ + + GS + G ++
Sbjct: 647 ACPLLALEVCQ-DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQ-GSQFVE 704
Query: 661 SCAISNVKKV 670
+ N+K V
Sbjct: 705 WASAGNLKPV 714
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 112 bits (280), Expect = 2e-24
Identities = 91/335 (27%), Positives = 145/335 (43%), Gaps = 15/335 (4%)
Query: 560 RKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIP 619
RKEP G+ II PWNYPL + LAAGN VV+KP++++ AE+ L +
Sbjct: 101 RKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEV-LPQYVD 159
Query: 620 KGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSP 679
+ V+ G GQ L D I FTGS VGK +M + A ++ V+LELGGK+P
Sbjct: 160 QSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGKNP 216
Query: 680 LIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNP 739
+ +CD +FN G+ C+A + + + + + + + +P
Sbjct: 217 CYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDP 276
Query: 740 LDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMF 799
+ ++ ++ + G V G Q + PTV DV++
Sbjct: 277 QS-------SPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEP 329
Query: 800 IAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVF 859
+ +EE FGP++ I LD + N E LA F+ V + +G
Sbjct: 330 VMQEEIFGPILPIVNVQ--SLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
Query: 860 VNT--YNKTDVAAPFGGFKQSGFGKDLGEAALNEY 892
N + T + PFGG SG G+ G+ + + +
Sbjct: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 112 bits (280), Expect = 2e-24
Identities = 91/335 (27%), Positives = 145/335 (43%), Gaps = 15/335 (4%)
Query: 560 RKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIP 619
RKEP G+ II PWNYPL + LAAGN VV+KP++++ AE+ L +
Sbjct: 64 RKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEV-LPQYVD 122
Query: 620 KGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSP 679
+ V+ G GQ L D I FTGS VGK +M + A ++ V+LELGGK+P
Sbjct: 123 QSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGKNP 179
Query: 680 LIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNP 739
+ +CD +FN G+ C+A + + + + + + + +P
Sbjct: 180 CYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDP 239
Query: 740 LDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMF 799
+ ++ ++ + G V G Q + PTV DV++
Sbjct: 240 QS-------SPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEP 292
Query: 800 IAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVF 859
+ +EE FGP++ I LD + N E LA F+ V + +G
Sbjct: 293 VMQEEIFGPILPIVNVQ--SLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
Query: 860 VNT--YNKTDVAAPFGGFKQSGFGKDLGEAALNEY 892
N + T + PFGG SG G+ G+ + + +
Sbjct: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 385
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 112 bits (280), Expect = 2e-24
Identities = 91/335 (27%), Positives = 145/335 (43%), Gaps = 15/335 (4%)
Query: 560 RKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIP 619
RKEP G+ II PWNYPL + LAAGN VV+KP++++ AE+ L +
Sbjct: 101 RKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEV-LPQYVD 159
Query: 620 KGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSP 679
+ V+ G GQ L D I FTGS VGK +M + A ++ V+LELGGK+P
Sbjct: 160 QSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVM-TAAAKHLTPVTLELGGKNP 216
Query: 680 LIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNP 739
+ +CD +FN G+ C+A + + + + + + + +P
Sbjct: 217 CYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDP 276
Query: 740 LDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMF 799
+ ++ ++ + G V G Q + PTV DV++
Sbjct: 277 QS-------SPNLGRIINQKQFQRLRALLGCGRVAIGGQSDESDRYIAPTVLVDVQEMEP 329
Query: 800 IAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVF 859
+ +EE FGP++ I LD + N E LA F+ V + +G
Sbjct: 330 VMQEEIFGPILPIVNVQ--SLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
Query: 860 VNT--YNKTDVAAPFGGFKQSGFGKDLGEAALNEY 892
N + T + PFGG SG G+ G+ + + +
Sbjct: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTF 422
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 110 bits (274), Expect = 8e-24
Identities = 90/340 (26%), Positives = 149/340 (43%), Gaps = 17/340 (5%)
Query: 561 KEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPK 620
KEP G+ II PWNYPL + LAAG+ VV+KP++++ T AE+ L + +
Sbjct: 21 KEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEV-LPQYLDQ 79
Query: 621 GVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPL 680
V+ G GQ L D I FTGS VGK +M + A ++ V+LELGGK+P
Sbjct: 80 SCFAVVLGGPQETGQLLEHKLDY--IFFTGSPRVGKIVM-TAATKHLTPVTLELGGKNPC 136
Query: 681 IIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPL 740
+ +CD +FN G+ C+A + + + + + + + +P
Sbjct: 137 YVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQ 196
Query: 741 DRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFI 800
+ ++ ++ + G V G Q + PTV DV++ +
Sbjct: 197 S-------SPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVDVQETEPV 249
Query: 801 AKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFV 860
+EE FGP++ I +D + N E LA F+ + ++ +G+
Sbjct: 250 MQEEIFGPILPIVNVQ--SVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGG 307
Query: 861 N---TYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKT 897
N TY ++ PFGG SG G+ G+ + + +T
Sbjct: 308 NEGFTYISL-LSVPFGGVGHSGMGRYHGKFTFDTFSHHRT 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,669,307
Number of Sequences: 37866
Number of extensions: 1554768
Number of successful extensions: 3163
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 3013
Number of HSP's gapped (non-prelim): 50
length of query: 902
length of database: 18,247,518
effective HSP length: 111
effective length of query: 791
effective length of database: 14,044,392
effective search space: 11109114072
effective search space used: 11109114072
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.