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Search of human proteins with 215820622
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|215820622 mixed lineage kinase domain-like isoform 2 [Homo
sapiens]
(263 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|215820622 mixed lineage kinase domain-like isoform 2 [Homo sa... 518 e-147
gi|22749323 mixed lineage kinase domain-like isoform 1 [Homo sap... 359 2e-99
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 37 0.018
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 37 0.023
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 36 0.030
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 36 0.030
gi|11693132 UPF2 regulator of nonsense transcripts homolog [Homo... 36 0.030
gi|18375676 UPF2 regulator of nonsense transcripts homolog [Homo... 36 0.030
gi|4557321 apolipoprotein A-I preproprotein [Homo sapiens] 36 0.039
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 36 0.039
gi|56549111 optineurin [Homo sapiens] 35 0.051
gi|56549109 optineurin [Homo sapiens] 35 0.051
gi|20149572 optineurin [Homo sapiens] 35 0.051
gi|56549107 optineurin [Homo sapiens] 35 0.051
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 35 0.067
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 35 0.067
gi|189217904 RPGRIP1-like isoform b [Homo sapiens] 35 0.067
gi|118442834 RPGRIP1-like isoform a [Homo sapiens] 35 0.067
gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precur... 35 0.067
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 35 0.067
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 35 0.067
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso... 35 0.087
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 35 0.087
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 35 0.087
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 35 0.087
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 35 0.087
gi|58530840 desmoplakin isoform I [Homo sapiens] 34 0.11
gi|58761544 amine oxidase (flavin containing) domain 2 isoform a... 34 0.11
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 34 0.11
gi|187761324 shootin1 isoform a [Homo sapiens] 34 0.11
>gi|215820622 mixed lineage kinase domain-like isoform 2 [Homo
sapiens]
Length = 263
Score = 518 bits (1333), Expect = e-147
Identities = 263/263 (100%), Positives = 263/263 (100%)
Query: 1 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 60
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
Sbjct: 1 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 60
Query: 61 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 120
AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
Sbjct: 61 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 120
Query: 121 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQSL 180
RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQSL
Sbjct: 121 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQSL 180
Query: 181 ESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDEC 240
ESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDEC
Sbjct: 181 ESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDEC 240
Query: 241 RAHDPSVRPSVDEILKKLSTFSK 263
RAHDPSVRPSVDEILKKLSTFSK
Sbjct: 241 RAHDPSVRPSVDEILKKLSTFSK 263
>gi|22749323 mixed lineage kinase domain-like isoform 1 [Homo
sapiens]
Length = 471
Score = 359 bits (921), Expect = 2e-99
Identities = 186/206 (90%), Positives = 190/206 (92%), Gaps = 3/206 (1%)
Query: 1 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 60
MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT
Sbjct: 1 MENLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTT 60
Query: 61 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 120
AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ
Sbjct: 61 AMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQ 120
Query: 121 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQSL 180
RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQ L
Sbjct: 121 RMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQYL 180
Query: 181 ESSSGKSPLEISRFKVKNVKTGSASG 206
K EI + ++K +K SG
Sbjct: 181 PP---KCMQEIPQEQIKEIKKEQLSG 203
Score = 120 bits (300), Expect = 2e-27
Identities = 58/58 (100%), Positives = 58/58 (100%)
Query: 206 GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 263
GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK
Sbjct: 414 GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 471
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 37.0 bits (84), Expect = 0.018
Identities = 38/215 (17%), Positives = 99/215 (46%), Gaps = 14/215 (6%)
Query: 43 EMLQDQGKRSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVN 102
E+++ K+S E+L + + +A ++ E + + + + + + L + +
Sbjct: 1026 EIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLK 1085
Query: 103 RKLSDVWKELSLLLQ--VEQRMPVSPISQGASWAQEDQQDADEDRRAFQM-------LRR 153
+L + L + +Q VE + +S ++QG + + ++ + ++ L +
Sbjct: 1086 EELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQ 1145
Query: 154 DNEKIEASLRRLEINMKEIKETLRQSLESSSGKSPLEISRFKVKNVKTGSASGCNSEKIR 213
D + E+ + +LE N+KE +E L+ S++++ L + K+K T + N + ++
Sbjct: 1146 DILEKESIILKLERNLKEFQEHLQDSVKNT---KDLNVKELKLKEEITQLTN--NLQDMK 1200
Query: 214 KLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVR 248
L+ +K ++E +L+E + A +++
Sbjct: 1201 HLLQLKEEEEETNRQETEKLKEELSASSARTQNLK 1235
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 36.6 bits (83), Expect = 0.023
Identities = 45/241 (18%), Positives = 101/241 (41%), Gaps = 24/241 (9%)
Query: 3 NLKHIITLGQVIHKRCEEMKYCKKQCRRLGHRVLGL---IKPLEMLQDQGKR--SVPSEK 57
N H L +++ ++ +E+K +K C R ++ L +K LE +Q + ++ + E
Sbjct: 2003 NKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKEN 2062
Query: 58 LTTAM-NRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLL 116
L A+ +R KA E A+ ++ +S R L N KL + +
Sbjct: 2063 LAQAVEHRKKAQAELASFKVLLDDTQSEAARVLAD----------NLKLKKELQSNKESV 2112
Query: 117 QVEQRMPVSPISQGASWAQEDQ-QDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKET 175
+ + + + + A+E ++ + LRR+ +E ++ +++ + + K+
Sbjct: 2113 KSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNK-KDK 2171
Query: 176 LRQSLESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELRE 235
Q L+ + + +++ F T S S ++ R + K+ + + S+ E
Sbjct: 2172 EVQQLQENLDSTVTQLAAF------TKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEE 2225
Query: 236 I 236
I
Sbjct: 2226 I 2226
Score = 29.3 bits (64), Expect = 3.7
Identities = 27/146 (18%), Positives = 64/146 (43%), Gaps = 9/146 (6%)
Query: 43 EMLQDQGKRSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVN 102
+++ + + + ++ L+++ K ALE + EK + ++ +
Sbjct: 1550 KLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAEST----EWQ 1605
Query: 103 RKLSDVWKELSLLLQVEQRMP--VSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEA 160
K ++ KE +LLQ + + I ++++Q+ R+ + +++ EK
Sbjct: 1606 EKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEK--- 1662
Query: 161 SLRRLEINMKEIKETLRQSLESSSGK 186
L+ E M+E+KE +R+ +S K
Sbjct: 1663 QLQEAEQEMEEMKEKMRKFAKSKQQK 1688
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 36.2 bits (82), Expect = 0.030
Identities = 51/245 (20%), Positives = 102/245 (41%), Gaps = 22/245 (8%)
Query: 37 GLIKPLEMLQDQGKRSVPSEKLTTAM-----NRFKAALEEANGEIEKFSNRSNICR--FL 89
G++K ++ D RS K AM N +A +EE +E+ I L
Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELL 1713
Query: 90 TASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQ 149
AS+ L N L + K+L + + + + I Q A A+E + A D
Sbjct: 1714 DASERVQLLHTQNTSLINTKKKLETDIS-QMQGEMEDILQEARNAEEKAKKAITDAAMMA 1772
Query: 150 MLRRDNEKIEASLRRLEINMKEIKETLRQSLESS------SGKSPLEISRFKVKNV--KT 201
+ + A L R++ NM++ + L+ L+ + GK ++ +V+ + +
Sbjct: 1773 EELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1832
Query: 202 GSASGCNSEKIRKLVAVKRQQEPLGEDCPSE------LREIIDECRAHDPSVRPSVDEIL 255
S N+E ++ L +R+ + L + L++++D+ +A S + +E
Sbjct: 1833 ESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAE 1892
Query: 256 KKLST 260
++ +T
Sbjct: 1893 EQSNT 1897
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 36.2 bits (82), Expect = 0.030
Identities = 51/245 (20%), Positives = 102/245 (41%), Gaps = 22/245 (8%)
Query: 37 GLIKPLEMLQDQGKRSVPSEKLTTAM-----NRFKAALEEANGEIEKFSNRSNICR--FL 89
G++K ++ D RS K AM N +A +EE +E+ I L
Sbjct: 1654 GILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELL 1713
Query: 90 TASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQ 149
AS+ L N L + K+L + + + + I Q A A+E + A D
Sbjct: 1714 DASERVQLLHTQNTSLINTKKKLETDIS-QMQGEMEDILQEARNAEEKAKKAITDAAMMA 1772
Query: 150 MLRRDNEKIEASLRRLEINMKEIKETLRQSLESS------SGKSPLEISRFKVKNV--KT 201
+ + A L R++ NM++ + L+ L+ + GK ++ +V+ + +
Sbjct: 1773 EELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEV 1832
Query: 202 GSASGCNSEKIRKLVAVKRQQEPLGEDCPSE------LREIIDECRAHDPSVRPSVDEIL 255
S N+E ++ L +R+ + L + L++++D+ +A S + +E
Sbjct: 1833 ESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAE 1892
Query: 256 KKLST 260
++ +T
Sbjct: 1893 EQSNT 1897
>gi|11693132 UPF2 regulator of nonsense transcripts homolog [Homo
sapiens]
Length = 1272
Score = 36.2 bits (82), Expect = 0.030
Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 5/115 (4%)
Query: 129 QGASWAQEDQQDADE---DRRAF--QMLRRDNEKIEASLRRLEINMKEIKETLRQSLESS 183
+G W ED ++ E D +AF +L +DNEK + + + KE KE+ SS
Sbjct: 455 EGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSCQNKESNKDDTKEAKESKENKEVSS 514
Query: 184 SGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREIID 238
LE+ ++ + G +E + K + +++QE S L+ I+D
Sbjct: 515 PDDLELELENLEINDDTLELEGGDEAEDLTKKLLDEQEQEDEEASTGSHLKLIVD 569
>gi|18375676 UPF2 regulator of nonsense transcripts homolog [Homo
sapiens]
Length = 1272
Score = 36.2 bits (82), Expect = 0.030
Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 5/115 (4%)
Query: 129 QGASWAQEDQQDADE---DRRAF--QMLRRDNEKIEASLRRLEINMKEIKETLRQSLESS 183
+G W ED ++ E D +AF +L +DNEK + + + KE KE+ SS
Sbjct: 455 EGGIWEDEDARNFYENLIDLKAFVPAILFKDNEKSCQNKESNKDDTKEAKESKENKEVSS 514
Query: 184 SGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREIID 238
LE+ ++ + G +E + K + +++QE S L+ I+D
Sbjct: 515 PDDLELELENLEINDDTLELEGGDEAEDLTKKLLDEQEQEDEEASTGSHLKLIVD 569
>gi|4557321 apolipoprotein A-I preproprotein [Homo sapiens]
Length = 267
Score = 35.8 bits (81), Expect = 0.039
Identities = 39/187 (20%), Positives = 80/187 (42%), Gaps = 33/187 (17%)
Query: 75 EIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWA 134
++ K S R + +F + L K +N KL D W ++ + R + P++Q
Sbjct: 44 DVLKDSGRDYVSQF----EGSALGKQLNLKLLDNWDSVTSTFS-KLREQLGPVTQ----- 93
Query: 135 QEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQSLESSSGK--SPLEIS 192
+ L ++ E + + + +++E+K ++ L+ K +E+
Sbjct: 94 -----------EFWDNLEKETEGLRQEMSK---DLEEVKAKVQPYLDDFQKKWQEEMELY 139
Query: 193 RFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVD 252
R KV+ ++ G +KL ++ + PLGE+ R +D R H + P D
Sbjct: 140 RQKVEPLRAELQEGAR----QKLHELQEKLSPLGEEMRDRARAHVDALRTH---LAPYSD 192
Query: 253 EILKKLS 259
E+ ++L+
Sbjct: 193 ELRQRLA 199
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 35.8 bits (81), Expect = 0.039
Identities = 16/44 (36%), Positives = 25/44 (56%)
Query: 216 VAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLS 259
VAV + P+ CP +++ EC DP +RPS IL++L+
Sbjct: 356 VAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLT 399
>gi|56549111 optineurin [Homo sapiens]
Length = 577
Score = 35.4 bits (80), Expect = 0.051
Identities = 43/203 (21%), Positives = 82/203 (40%), Gaps = 33/203 (16%)
Query: 16 KRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQ-GKRSVPSEKLTTAMNRFKAALEEANG 74
K+ EE ++ + Q + R++ L E L+++ GK SE+ + + L A
Sbjct: 78 KQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTD-DSRLPRAEA 136
Query: 75 EIEKFSNRSNICRFLTASQDKI-LFKDVNRKLSDVWKELSLLLQVEQRM----------- 122
E EK R+ + R D + + ++ KL+ +++
Sbjct: 137 EQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIK 196
Query: 123 ----PVSPISQGASWAQEDQQDADEDRRAFQ-----------MLRRDNEKIEASLRRLEI 167
P +S G + ++ + AD + F+ LR N+K+E RLE+
Sbjct: 197 HSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEV 252
Query: 168 NMKEIKETLRQSLESSSGKSPLE 190
+KE KE + + +S +S +E
Sbjct: 253 ALKEAKERVSDFEKKTSNRSEIE 275
>gi|56549109 optineurin [Homo sapiens]
Length = 577
Score = 35.4 bits (80), Expect = 0.051
Identities = 43/203 (21%), Positives = 82/203 (40%), Gaps = 33/203 (16%)
Query: 16 KRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQ-GKRSVPSEKLTTAMNRFKAALEEANG 74
K+ EE ++ + Q + R++ L E L+++ GK SE+ + + L A
Sbjct: 78 KQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTD-DSRLPRAEA 136
Query: 75 EIEKFSNRSNICRFLTASQDKI-LFKDVNRKLSDVWKELSLLLQVEQRM----------- 122
E EK R+ + R D + + ++ KL+ +++
Sbjct: 137 EQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIK 196
Query: 123 ----PVSPISQGASWAQEDQQDADEDRRAFQ-----------MLRRDNEKIEASLRRLEI 167
P +S G + ++ + AD + F+ LR N+K+E RLE+
Sbjct: 197 HSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEV 252
Query: 168 NMKEIKETLRQSLESSSGKSPLE 190
+KE KE + + +S +S +E
Sbjct: 253 ALKEAKERVSDFEKKTSNRSEIE 275
>gi|20149572 optineurin [Homo sapiens]
Length = 577
Score = 35.4 bits (80), Expect = 0.051
Identities = 43/203 (21%), Positives = 82/203 (40%), Gaps = 33/203 (16%)
Query: 16 KRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQ-GKRSVPSEKLTTAMNRFKAALEEANG 74
K+ EE ++ + Q + R++ L E L+++ GK SE+ + + L A
Sbjct: 78 KQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTD-DSRLPRAEA 136
Query: 75 EIEKFSNRSNICRFLTASQDKI-LFKDVNRKLSDVWKELSLLLQVEQRM----------- 122
E EK R+ + R D + + ++ KL+ +++
Sbjct: 137 EQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIK 196
Query: 123 ----PVSPISQGASWAQEDQQDADEDRRAFQ-----------MLRRDNEKIEASLRRLEI 167
P +S G + ++ + AD + F+ LR N+K+E RLE+
Sbjct: 197 HSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEV 252
Query: 168 NMKEIKETLRQSLESSSGKSPLE 190
+KE KE + + +S +S +E
Sbjct: 253 ALKEAKERVSDFEKKTSNRSEIE 275
>gi|56549107 optineurin [Homo sapiens]
Length = 577
Score = 35.4 bits (80), Expect = 0.051
Identities = 43/203 (21%), Positives = 82/203 (40%), Gaps = 33/203 (16%)
Query: 16 KRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQ-GKRSVPSEKLTTAMNRFKAALEEANG 74
K+ EE ++ + Q + R++ L E L+++ GK SE+ + + L A
Sbjct: 78 KQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTD-DSRLPRAEA 136
Query: 75 EIEKFSNRSNICRFLTASQDKI-LFKDVNRKLSDVWKELSLLLQVEQRM----------- 122
E EK R+ + R D + + ++ KL+ +++
Sbjct: 137 EQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIK 196
Query: 123 ----PVSPISQGASWAQEDQQDADEDRRAFQ-----------MLRRDNEKIEASLRRLEI 167
P +S G + ++ + AD + F+ LR N+K+E RLE+
Sbjct: 197 HSPGPTRTVSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE----RLEV 252
Query: 168 NMKEIKETLRQSLESSSGKSPLE 190
+KE KE + + +S +S +E
Sbjct: 253 ALKEAKERVSDFEKKTSNRSEIE 275
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 35.0 bits (79), Expect = 0.067
Identities = 15/37 (40%), Positives = 23/37 (62%)
Query: 224 PLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLST 260
P+ +CP L ++ +C A+DPS RP E+ +LST
Sbjct: 664 PMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLST 700
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 35.0 bits (79), Expect = 0.067
Identities = 15/37 (40%), Positives = 23/37 (62%)
Query: 224 PLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLST 260
P+ +CP L ++ +C A+DPS RP E+ +LST
Sbjct: 642 PMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLST 678
>gi|189217904 RPGRIP1-like isoform b [Homo sapiens]
Length = 1235
Score = 35.0 bits (79), Expect = 0.067
Identities = 50/247 (20%), Positives = 106/247 (42%), Gaps = 44/247 (17%)
Query: 14 IHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTTAMNRFKAALEEAN 73
+ K+ MK+ +++ L R+ L K E+L++ + S F AA EE
Sbjct: 327 LEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS--------AFSAAHEE-Q 377
Query: 74 GEIEKFSNRSNICRFLTASQDKILFK-----------DVNRKLSDVWKELSLLLQVEQRM 122
++++ + I + TA + + K D N KL +EL L +EQ+
Sbjct: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQ-LQYLEQKQ 436
Query: 123 PVSPISQGAS-WAQEDQQDADEDRRAFQMLRRDNE----------KIEASLRR-LEINMK 170
+ + + + QE+ +ADE A +++ E K+++ + + LE +M+
Sbjct: 437 QLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMR 496
Query: 171 EIKETLRQSLESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCP 230
E++ T ++++ + I + K+ N + ++ AV R+ E L +D
Sbjct: 497 ELQATHAETVQELEKTRNMLIMQHKI-----------NKDYQMEVEAVTRKMENLQQDYE 545
Query: 231 SELREII 237
++ + +
Sbjct: 546 LKVEQYV 552
>gi|118442834 RPGRIP1-like isoform a [Homo sapiens]
Length = 1315
Score = 35.0 bits (79), Expect = 0.067
Identities = 50/247 (20%), Positives = 106/247 (42%), Gaps = 44/247 (17%)
Query: 14 IHKRCEEMKYCKKQCRRLGHRVLGLIKPLEMLQDQGKRSVPSEKLTTAMNRFKAALEEAN 73
+ K+ MK+ +++ L R+ L K E+L++ + S F AA EE
Sbjct: 327 LEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS--------AFSAAHEE-Q 377
Query: 74 GEIEKFSNRSNICRFLTASQDKILFK-----------DVNRKLSDVWKELSLLLQVEQRM 122
++++ + I + TA + + K D N KL +EL L +EQ+
Sbjct: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQ-LQYLEQKQ 436
Query: 123 PVSPISQGAS-WAQEDQQDADEDRRAFQMLRRDNE----------KIEASLRR-LEINMK 170
+ + + + QE+ +ADE A +++ E K+++ + + LE +M+
Sbjct: 437 QLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMR 496
Query: 171 EIKETLRQSLESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCP 230
E++ T ++++ + I + K+ N + ++ AV R+ E L +D
Sbjct: 497 ELQATHAETVQELEKTRNMLIMQHKI-----------NKDYQMEVEAVTRKMENLQQDYE 545
Query: 231 SELREII 237
++ + +
Sbjct: 546 LKVEQYV 552
>gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precursor
[Homo sapiens]
Length = 734
Score = 35.0 bits (79), Expect = 0.067
Identities = 18/51 (35%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 208 NSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL 258
N E + +V R P G CP + I+ +C H+P +RPS IL++L
Sbjct: 599 NQEVLDFVVGGGRMDPPRG--CPGPVYRIMTQCWQHEPELRPSFASILERL 647
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 35.0 bits (79), Expect = 0.067
Identities = 18/51 (35%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 208 NSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL 258
N E + +V R P G CP + I+ +C H+P +RPS IL++L
Sbjct: 729 NQEVLDFVVGGGRMDPPRG--CPGPVYRIMTQCWQHEPELRPSFASILERL 777
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 35.0 bits (79), Expect = 0.067
Identities = 18/51 (35%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 208 NSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKL 258
N E + +V R P G CP + I+ +C H+P +RPS IL++L
Sbjct: 668 NQEVLDFVVGGGRMDPPRG--CPGPVYRIMTQCWQHEPELRPSFASILERL 716
>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
isoform 1 [Homo sapiens]
Length = 937
Score = 34.7 bits (78), Expect = 0.087
Identities = 18/56 (32%), Positives = 32/56 (57%), Gaps = 1/56 (1%)
Query: 206 GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTF 261
G +++++ ++V KRQ P EDCP + ++ EC PS RP +I +L ++
Sbjct: 695 GFSNQEVIEMVR-KRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSW 749
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
sapiens]
Length = 1038
Score = 34.7 bits (78), Expect = 0.087
Identities = 14/45 (31%), Positives = 25/45 (55%)
Query: 206 GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPS 250
G N +I + + ++ P EDCP ++ ++ +C AH P RP+
Sbjct: 333 GLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPT 377
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
sapiens]
Length = 1086
Score = 34.7 bits (78), Expect = 0.087
Identities = 14/45 (31%), Positives = 25/45 (55%)
Query: 206 GCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPS 250
G N +I + + ++ P EDCP ++ ++ +C AH P RP+
Sbjct: 396 GLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPT 440
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 34.7 bits (78), Expect = 0.087
Identities = 29/106 (27%), Positives = 46/106 (43%), Gaps = 21/106 (19%)
Query: 119 EQRMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQ 178
E + + + QG W+ ED D DED A + + NE L L+ M+E+KE
Sbjct: 184 ELKKEIEEMKQGKKWSLEDDDD-DEDDPA-EAEKEGNEMEGEELDPLDAYMEEVKE---- 237
Query: 179 SLESSSGKSPLEISRFKVKNVKTGSA----SGCNSEKIRKLVAVKR 220
E+ +F +++VK G SG K+ +V K+
Sbjct: 238 -----------EVKKFNMRSVKGGGGNEKKSGPTVTKVVTVVTTKK 272
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 34.7 bits (78), Expect = 0.087
Identities = 15/48 (31%), Positives = 26/48 (54%)
Query: 216 VAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 263
VA+ + P+ CP +++++C DP RPS IL +L+T +
Sbjct: 361 VAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEE 408
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 34.3 bits (77), Expect = 0.11
Identities = 42/165 (25%), Positives = 75/165 (45%), Gaps = 24/165 (14%)
Query: 50 KRSVPSEKLTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVW 109
+R+V + +T RF+ +L+E + +K N + TAS+D K + +L +
Sbjct: 1548 ERTVKDQDIT----RFQNSLKELQLQKQKVEEELNRLK-RTASEDSCKRKKLEEELEGMR 1602
Query: 110 KEL--------SLLLQVEQRMPVSPISQGASWAQEDQQDAD--EDRRAFQMLRRDNEKIE 159
+ L +L Q+EQ V S+ Q D D E +R + LRR + ++E
Sbjct: 1603 RSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVE 1662
Query: 160 ASLRRLEINMKEIK------ETLRQSLESSS---GKSPLEISRFK 195
A R+L + +K E ++++E S +S +EI R +
Sbjct: 1663 ALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707
Score = 29.6 bits (65), Expect = 2.8
Identities = 40/201 (19%), Positives = 84/201 (41%), Gaps = 24/201 (11%)
Query: 16 KRCEEMKYCKKQCRRLGHRVLGLIKPLE--MLQDQGKRSVPSEKLTTAMNRFKAALEEAN 73
+R EE +K C G ++ + LE + Q +RS + + ++ +++ N
Sbjct: 1268 RRAEENALQQKAC---GSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKN 1324
Query: 74 GEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDVWKE--LSLLLQVEQRMPVSPISQGA 131
EIE+ F ++ + +++ K+ + + E +SL Q E + ++ +
Sbjct: 1325 KEIERLK-----AEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQ 1379
Query: 132 SWAQEDQQDADEDRRAFQMLRRDNEKIEASLRRLEINMKEIKETLRQ-----------SL 180
Q+++ D R L R+N + ++RL+ + + E LR+
Sbjct: 1380 LTMQKEE-DTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS 1438
Query: 181 ESSSGKSPLEISRFKVKNVKT 201
E S K LE+ +V ++T
Sbjct: 1439 EVSQRKQQLEVELRQVTQMRT 1459
>gi|58761544 amine oxidase (flavin containing) domain 2 isoform a
[Homo sapiens]
Length = 876
Score = 34.3 bits (77), Expect = 0.11
Identities = 48/186 (25%), Positives = 84/186 (45%), Gaps = 28/186 (15%)
Query: 66 KAALEEANGEIEKFSNRSNICRFLTASQDKILFKDVNRKLSDV-WKELSLLLQVEQRMPV 124
K L EANG+ + + +D+++ ++ NR L + L V PV
Sbjct: 379 KCPLYEANGQADTVK--------VPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPV 430
Query: 125 SPISQGASWAQEDQQD--ADEDRRAFQMLRRDNEKIEASLRRLEINMKE-IKETLRQSLE 181
S + Q + Q+ DE ++ + + E+++ L ++ +N+KE IKE +Q E
Sbjct: 431 S-LGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKM-VNLKEKIKELHQQYKE 488
Query: 182 SSSGKSPLEI-SRFKVKNVKTGSASGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDEC 240
+S K P +I + F VK+ K R L A+ ++ + L E +L E + E
Sbjct: 489 ASEVKPPRDITAEFLVKS------------KHRDLTALCKEYDELAE-TQGKLEEKLQEL 535
Query: 241 RAHDPS 246
A+ PS
Sbjct: 536 EANPPS 541
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 34.3 bits (77), Expect = 0.11
Identities = 15/48 (31%), Positives = 23/48 (47%)
Query: 216 VAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLSTFSK 263
VA+ + P+ CP +++EC DP RP ILK+L +
Sbjct: 315 VAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQ 362
>gi|187761324 shootin1 isoform a [Homo sapiens]
Length = 631
Score = 34.3 bits (77), Expect = 0.11
Identities = 48/224 (21%), Positives = 97/224 (43%), Gaps = 23/224 (10%)
Query: 40 KPLEMLQDQGKRSVPSEK--LTTAMNRFKAALEEANGEIEKFSNRSNICRFLTASQDKIL 97
K ++ L+DQ SV EK L + K+ L E E+ K + Q K+L
Sbjct: 142 KQIKELRDQIV-SVQEEKKILAIELENLKSKLVEVIEEVNKVKQEKTVLNSEVLEQRKVL 200
Query: 98 FK--DVNRKLSDVWKELSLLLQVEQRMPVSPISQGASWAQEDQQDADEDRRAFQMLRRDN 155
K V+ + ++E+ + L++E+ + + S+AQE + ++ +R +L + +
Sbjct: 201 EKCNRVSMLAVEEYEEMQVNLELEKDLR----KKAESFAQEMFIEQNKLKRQSHLLLQSS 256
Query: 156 EKIEASLRRLEINMKEIKETLRQSLESSSGKSPLEISRFKVKNVKTGSASGCNSEKIRKL 215
+ L+ L+ N K ++ + ++ KVK ++ +E + K
Sbjct: 257 IPDQQLLKALDENAKLTQQLEEERIQHQQ----------KVKELE----EQLENETLHKE 302
Query: 216 VAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEILKKLS 259
+ +QQ L E+ EL +++ SVDE+ K+++
Sbjct: 303 IHNLKQQLELLEEDKKELELKYQNSEEKARNLKHSVDELQKRVN 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,360,895
Number of Sequences: 37866
Number of extensions: 391648
Number of successful extensions: 2297
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 176
Number of HSP's that attempted gapping in prelim test: 2132
Number of HSP's gapped (non-prelim): 394
length of query: 263
length of database: 18,247,518
effective HSP length: 100
effective length of query: 163
effective length of database: 14,460,918
effective search space: 2357129634
effective search space used: 2357129634
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.