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Search of human proteins with 21450705
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
(670 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 1267 0.0
gi|148746195 trichohyalin [Homo sapiens] 102 1e-21
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 100 6e-21
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 100 6e-21
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 100 6e-21
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 100 6e-21
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 100 6e-21
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 100 6e-21
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 100 6e-21
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 100 6e-21
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 97 6e-20
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 96 8e-20
gi|118918429 NOD3 protein [Homo sapiens] 94 5e-19
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 92 2e-18
gi|168986655 hypothetical protein LOC145497 [Homo sapiens] 91 3e-18
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 90 6e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 89 1e-17
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 89 2e-17
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 89 2e-17
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 88 2e-17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 88 2e-17
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 87 4e-17
gi|31982906 cingulin-like 1 [Homo sapiens] 87 4e-17
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 87 5e-17
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 87 6e-17
gi|28416946 myosin 18A isoform a [Homo sapiens] 87 6e-17
gi|34577114 cytomatrix protein p110 [Homo sapiens] 86 8e-17
gi|156104908 myosin heavy chain 6 [Homo sapiens] 86 8e-17
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 86 1e-16
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 86 1e-16
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 1267 bits (3279), Expect = 0.0
Identities = 670/670 (100%), Positives = 670/670 (100%)
Query: 1 MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLC 60
MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLC
Sbjct: 1 MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLC 60
Query: 61 TELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLT 120
TELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLT
Sbjct: 61 TELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLT 120
Query: 121 LEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLR 180
LEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLR
Sbjct: 121 LEWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLR 180
Query: 181 WNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQAR 240
WNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQAR
Sbjct: 181 WNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQAR 240
Query: 241 THVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINA 300
THVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINA
Sbjct: 241 THVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINA 300
Query: 301 LKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLR 360
LKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLR
Sbjct: 301 LKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLR 360
Query: 361 DLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKR 420
DLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKR
Sbjct: 361 DLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKR 420
Query: 421 RCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSER 480
RCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSER
Sbjct: 421 RCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSER 480
Query: 481 GQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQL 540
GQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQL
Sbjct: 481 GQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQL 540
Query: 541 GLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL 600
GLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL
Sbjct: 541 GLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL 600
Query: 601 ERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQA 660
ERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQA
Sbjct: 601 ERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQA 660
Query: 661 SPVRTLSPPK 670
SPVRTLSPPK
Sbjct: 661 SPVRTLSPPK 670
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 102 bits (253), Expect = 1e-21
Identities = 120/480 (25%), Positives = 208/480 (43%), Gaps = 67/480 (13%)
Query: 221 EQAMGHSQDRLTTFQENQA-----RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAK 275
+Q QDR+ FQE + R VL KE + L+EE+ ++ +L E + E++ K
Sbjct: 227 QQQRRERQDRV--FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE----EEEQLRK 280
Query: 276 SSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
R R Q +E +R L+ K + ++ Q+ E ++QL
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 336 LSQRQAKELKLEQQEAAERESKLLR--------DLSAANEKNLLLQNQV---DELERKFR 384
Q + +E +L +++ ER + LR + E+ L + Q+ +L R+ +
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ 400
Query: 385 CQQEQLFQTRQEMT---SMSAELKMRAIQAEERLDM--EKRRCRQSLEDSESLR---IKE 436
++EQ + Q++ + E ++R Q EER + E+ R Q L+ + R +K
Sbjct: 401 LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR 460
Query: 437 VEHMTRHLEESEKAMQERVQRLEAAR--LSLEEE------------LSRVKAAALSERGQ 482
E RH +E K +R Q E L LEEE L R + +R +
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLK 520
Query: 483 AEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGL 542
+EE + + + R E+Q R E + +LL + ++ +++++ E + R QL
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL-- 578
Query: 543 QVEGLRRRLEELQQELSLKDQERVAE-VSRVRVELQEQNGRLQAELAAQEALREKAAAL- 600
L+R E QQ L + +ER+ + + R VE EQ R + L +E E+ L
Sbjct: 579 ----LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 601 ---------ERQLKVMASDHREALLDRESENASLREKLR------LREAEIARIRDEEAQ 645
++QL+ + RE L RE E L ++L+ RE E+A E+A+
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQAR 694
Score = 96.3 bits (238), Expect = 8e-20
Identities = 110/445 (24%), Positives = 195/445 (43%), Gaps = 42/445 (9%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQL 287
Q+R E + E + +E+ + +L+E K REE + R RV Q
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE 240
Query: 288 QEALN--ERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLS----QRQA 341
+E +R +++ + KLQ E +++ Q+ E L E+++L ++Q
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQ---RQRELQEEEEQLRKLERQELRRERQEEEQQQ 297
Query: 342 KELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF--QTRQEMTS 399
+ L+ EQQ ++E + E+ + Q + E++ R +QE+ Q R+E
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 400 MSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLE 459
E ++R Q EER + + RR Q L + LR ++ + L ++ +E+ R E
Sbjct: 358 ERREQQLRREQEEERREQQLRR-EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 460 AARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEA 519
+L E++L R + ER + + E + + + + E+++R D L+ +
Sbjct: 417 Q-QLRREQQLRREQE---EERHEQKHEQERREQRLKREQEER----RDWLKREEETERHE 468
Query: 520 QGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQ 579
Q QQ + E + R L L+ E R + E +Q+L + +ER + R++ QE+
Sbjct: 469 QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ----RLKRQEE 524
Query: 580 NGRLQAELAAQEALR---------------EKAAALER---QLKVMASDHREALLDRESE 621
RLQ L +++ LR EK ER +LK + R+ LL RE E
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 622 NASLREKLRLREAEIARIRDEEAQR 646
R K E R++ EE +R
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVER 609
Score = 88.2 bits (217), Expect = 2e-17
Identities = 115/462 (24%), Positives = 208/462 (45%), Gaps = 46/462 (9%)
Query: 217 LRAVEQAMGHSQDRLTTFQE------NQARTHVLSKEVQHL-REEKSKQFLDLMETIDKQ 269
LR E+ QDR F+E Q R +E Q + R+E+ ++FL+ + + ++
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE 1458
Query: 270 REEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDL-GELLAT 328
R + + Q ER + +L+ E EQ+ + E
Sbjct: 1459 RHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518
Query: 329 AEQEQLSLSQRQAKELKLEQQ---EAAERESKLLRDLSAANEKNLLLQNQVDEL-----E 380
E++QL QRQ K L+ EQQ + ++ + RD E+ L + + +L +
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578
Query: 381 RKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEK----RRCRQSLEDSESLRIKE 436
RKFR +++++ + QE M E ++R + +++L E+ R Q L++ E ++
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638
Query: 437 VEHMTRHLEES-EKAMQERVQRL---------EAARLSLEEELSRVKAAALSERGQAEEE 486
E + LEE + QER Q+L E +L E E +++ + + EE+
Sbjct: 1639 QERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQ 1698
Query: 487 LIKAKSQAR--LEEQQRL--AHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGL 542
++ + + R L+E+Q+L LE K R Q R E +Q+Q+ Q R ++ L
Sbjct: 1699 QLRRQERERKFLQEEQQLRRQELERKFREEEQLRQET-----EQEQL--RRQERYRKI-L 1750
Query: 543 QVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALER 602
+ E LR EE Q +D+ + E ++R E +EQ +L+++ + ++ E+ ER
Sbjct: 1751 EEEQLRPEREEQQLRRQERDR-KFREEEQLRQEREEQ--QLRSQESDRKFREEEQLRQER 1807
Query: 603 QLKVMASDHREALLDRESENASLRE-KLRLREAEIARIRDEE 643
+ + + R+ E E L E + RLR+ + R EE
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEE 1849
Score = 86.7 bits (213), Expect = 6e-17
Identities = 105/436 (24%), Positives = 195/436 (44%), Gaps = 21/436 (4%)
Query: 218 RAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSS 277
R +E+ G + + QE + E Q E++ +Q D E + +QR+E +
Sbjct: 127 RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRD--EELWRQRQEWQERE 184
Query: 278 --RASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
RA ++ + E L+ + ++ E E+K Q E QE+
Sbjct: 185 ERRAEEEQLQSCKGHETEEFPDEEQLRRR-ELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 336 LSQRQAKE-LKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTR 394
R+ + L+ E+++ E E + R+L E+ L+ Q ER+ QQ+Q +
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE 303
Query: 395 QEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHL-EESEKAMQE 453
Q++ E R Q EER + ++RR +Q + LR ++ E + L E E+ +E
Sbjct: 304 QQLRRKQEE--ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE 361
Query: 454 RVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLA 513
+ R E E++L R + ++ + E++L + + Q R E+Q R E +LR
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQL-RREQQLRREQQLR---REQQLRREQ 417
Query: 514 QARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVR 573
Q R E Q +++ E + + + + L+R EE + L +++ E R +
Sbjct: 418 QLRREQQ----LRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRK 473
Query: 574 VEL---QEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLR 630
+L QE+ R + +E RE+ E+QL+ + RE L R+ E L+++LR
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 631 LREAEIARIRDEEAQR 646
E ++ R ++E ++
Sbjct: 534 -SEQQLRREQEERREQ 548
Score = 82.8 bits (203), Expect = 9e-16
Identities = 111/466 (23%), Positives = 209/466 (44%), Gaps = 49/466 (10%)
Query: 221 EQAMGHSQDRLTTFQENQARTH-----VLSKEVQHLREEKSKQFLDLMETIDKQ-REEMA 274
E+ Q+R F+E + R+ L +E Q R+++ ++FL + + +Q R +
Sbjct: 1490 EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549
Query: 275 KSSRASAARVG-QLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQE- 332
+ R R QL++ E+ K ++ E + EQ+ + + + QE
Sbjct: 1550 RQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG 1609
Query: 333 QLSLSQRQAKELKLEQQEAAERESKLL----RDLSAANEKNLLLQNQVDEL-----ERKF 383
Q L Q + ++ + ++Q ERE + L RD E+ L + + ++ +RKF
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 384 RCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRH 443
R ++EQL Q +E E + + E++L ++R R+ L++ + LR +E+E R
Sbjct: 1670 R-EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE-RKFLQEEQQLRRQELERKFRE 1727
Query: 444 LEE-SEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLE-EQQR 501
E+ ++ QE+++R E R LEEE R + R Q + + + Q R E E+Q+
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ 1787
Query: 502 LAHLED--KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELS 559
L E K R Q R E + L+ +Q + + R + LQ+E +RL + +++
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQ--RDGKYRWEEEQLQLEEQEQRLRQ-ERDRQ 1844
Query: 560 LKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRE 619
+ +E+ A QE++ R + EL +E E+ ER+ K+
Sbjct: 1845 YRAEEQFAT--------QEKSRREEQELWQEE---EQKRRQERERKL------------R 1881
Query: 620 SENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQASPVRT 665
E+ ++K R ++ I+ +E + L + PVR+
Sbjct: 1882 EEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRS 1927
Score = 82.4 bits (202), Expect = 1e-15
Identities = 109/442 (24%), Positives = 192/442 (43%), Gaps = 29/442 (6%)
Query: 221 EQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEM--AKSSR 278
E+ H Q + +E Q R + + + E+ +Q L + +QRE A+ +
Sbjct: 750 EEERAHRQQQ----EEEQRRDFTWQWQAEE-KSERGRQRLSARPPLREQRERQLRAEERQ 804
Query: 279 ASAARVGQLQEALNERHSIINALKAKLQMTEAALALSE-QKAQDLGEL---LATAEQEQL 334
R +E +R + +LQ E L ++AQ L E L ++ +
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864
Query: 335 SLSQRQAKELKLEQQEAAERESKLLRDLSAANEK----NLLLQNQVDEL---ERKFRCQQ 387
S QR+ ++ + + +E +R L A E+ LLQ + +EL ER+ R +Q
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 388 EQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEES 447
EQ Q R+E E ++ + E+R E+ R + L+ KE + + E+
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERER---QYRKDKKLQQKEEQLLGEEPEKR 981
Query: 448 EKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLED 507
+ +E+ R E EE+L R + R Q E + K + + EE+Q L +
Sbjct: 982 RRQEREKKYREEEELQQEEEQLLREERE--KRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 508 KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVA 567
K RL + R + LQQ++ + R ++ ++E R+ EELQQE ++Q
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE---EEQLLRE 1096
Query: 568 EVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLR- 626
E + R + +E+ R + EL +E + +R+ + + +RE ++ E LR
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 627 --EKLRLREAEIARIRDEEAQR 646
EK R +E E +EE Q+
Sbjct: 1157 EPEKRRRQELERQYREEEELQQ 1178
Score = 80.5 bits (197), Expect = 5e-15
Identities = 115/457 (25%), Positives = 205/457 (44%), Gaps = 82/457 (17%)
Query: 215 DVLRAVEQAMGHSQDR----LTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQR 270
D L+ E+ H Q+R L QE + R L E + RE++ ++ L +++R
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR 515
Query: 271 EEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE 330
E+ K +E L +R L+++ Q+ ++ ++ E L E
Sbjct: 516 EQRLKRQEE--------EERLQQR------LRSEQQL--------RREQEERREQLLKRE 553
Query: 331 QEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKF------R 384
+E+ +R+ + LK EQ+E R+ L R+ ++ L + Q + LE++ R
Sbjct: 554 EEKRLEQERREQRLKREQEE--RRDQLLKREEERRQQR--LKREQEERLEQRLKREEVER 609
Query: 385 CQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHL 444
+QE+ + R + E + + +++EE+ + +++ R+ ++ R+K
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR-------- 661
Query: 445 EESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAH 504
EE E+ +++R++R E E R E+ AEEE + QAR + R+
Sbjct: 662 EEEEERLEQRLKR--------EHEEER------REQELAEEE----QEQARERIKSRIPK 703
Query: 505 LEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQ-QELSLKDQ 563
+ +L A AR +++ +KQ E Q R + Q E RRR ELQ QE +
Sbjct: 704 WQWQLESEADAR-QSKVYSRPRKQ---EGQRRRQE---QEEKRRRRESELQWQEEERAHR 756
Query: 564 ERVAEVSR----VRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHRE-ALLDR 618
++ E R + + +E++ R + L+A+ LRE+ ERQL+ RE L
Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR---ERQLRAEERQQREQRFLPE 813
Query: 619 ESENASLREKLRLREAEIARIRDEE----AQRASFLQ 651
E E R + R RE E+ + +EE +RA LQ
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Score = 77.4 bits (189), Expect = 4e-14
Identities = 106/447 (23%), Positives = 196/447 (43%), Gaps = 50/447 (11%)
Query: 218 RAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLD----LMETIDKQREEM 273
R EQ +L Q Q H+L ++ + RE++ +++ E +REE
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 274 AKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLG--ELLATAEQ 331
++ R + Q ER + + E L E++ Q L E +
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364
Query: 332 EQLSLSQRQAKELKLEQQ-EAAERESKLLRDLSAANEKNLLLQNQVDEL----ERKFRCQ 386
E+L ++ K L+ EQ+ ERE K L++ E+ L Q + +L +RKFR +
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKE-----EQQLRCQEREQQLRQDRDRKFREE 1419
Query: 387 QEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEE 446
++QL +RQE + R + EE+ + R R+ LE+ + LR + R E
Sbjct: 1420 EQQL--SRQE--------RDRKFREEEQQVRRQERERKFLEEEQQLR----QERHRKFRE 1465
Query: 447 SEKAMQER----VQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRL 502
E+ +QER + R E R LEEE + +R E+EL + + + E+++
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE--RDRKFREQELRSQEPERKFLEEEQQ 1523
Query: 503 AHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKD 562
H + + R Q + + +Q++ Q R + + E LR+ EE Q+LS ++
Sbjct: 1524 LHRQQRQRKFLQEEQQLR----RQERGQQRRQDRDRKF-REEEQLRQEREE--QQLSRQE 1576
Query: 563 QERVAEVSRVRVELQEQNGRL---QAELAAQEALREKAAALERQLKVMASDHREALLDRE 619
++R + +V QEQ + + +L QE ++ +R+ + + + L +RE
Sbjct: 1577 RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFR----EDEQLLQERE 1632
Query: 620 SENASLREKLRLREAEIARIRDEEAQR 646
+ +E+ R E ++R +E ++
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQ 1659
Score = 73.9 bits (180), Expect = 4e-13
Identities = 98/404 (24%), Positives = 173/404 (42%), Gaps = 56/404 (13%)
Query: 253 EEKSKQFLDLMETI--DKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEA 310
+E+ + D E++ D+++EE R R QL+E +R + K Q E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEE---DQRRFEPRDRQLEEEPGQRR------RQKRQEQER 146
Query: 311 ALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKL--EQQEAAERESKLLRDLSAANEK 368
LA E++++ +QE+L RQ ++ +L ++QE ERE + + + K
Sbjct: 147 ELAEGEEQSE---------KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197
Query: 369 NLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLED 428
+ DE + + R E + R+E E + R Q EE + KR
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR-------- 249
Query: 429 SESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELI 488
E++ KE E + + ++ +QE EE+L +++ L Q EE+
Sbjct: 250 -ETVLRKEEEKLQEEEPQRQRELQEE-----------EEQLRKLERQELRRERQEEEQ-- 295
Query: 489 KAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLR 548
Q RL +Q+L +++ R Q Q +Q++ E Q R Q + + LR
Sbjct: 296 ---QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352
Query: 549 RRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALR-EKAAALERQLKVM 607
R EE ++E L+ ++ E +EQ R + +L ++ LR E+ E+QL+
Sbjct: 353 REQEEERREQQLRREQEE--------ERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 608 ASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQ 651
RE L RE + ++ R +E E + E+ +R L+
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448
Score = 69.3 bits (168), Expect = 1e-11
Identities = 93/368 (25%), Positives = 165/368 (44%), Gaps = 42/368 (11%)
Query: 220 VEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRA 279
+E+ Q++ F E++ + + Q LR+E+ ++F + + + ++ E+
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQ-QQLRQERDRKFREDEQLLQEREEQ------- 1634
Query: 280 SAARVGQLQEALNERHSIINALKAKLQMTEAALALS-EQKAQDLGELLATAEQEQLSLSQ 338
QL +R + + + Q E L ++K ++ +LL E++QL +
Sbjct: 1635 ------QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQE 1688
Query: 339 RQAKELKLEQQ-EAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEM 397
R K + EQQ ERE K L++ E+ L Q ELERKFR ++EQL Q E
Sbjct: 1689 RDRKFREEEQQLRRQERERKFLQE-----EQQLRRQ----ELERKFR-EEEQLRQ-ETEQ 1737
Query: 398 TSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQR 457
+ + + R I EE+L E+ +Q + +E E + + EE + QE ++
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREE-QQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796
Query: 458 L-EAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQ-QRLAHLEDKLRLLAQA 515
E +L E E +++ + + EEE Q +LEEQ QRL D+ Q
Sbjct: 1797 FREEEQLRQEREEQQLRPQQRDGKYRWEEE------QLQLEEQEQRLRQERDR-----QY 1845
Query: 516 RDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVE 575
R E Q A Q+K E + + + + R+L E K+++R +V ++ +
Sbjct: 1846 RAEEQFA-TQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQ 1904
Query: 576 LQEQNGRL 583
+ +GRL
Sbjct: 1905 EGKGHGRL 1912
Score = 68.6 bits (166), Expect = 2e-11
Identities = 101/466 (21%), Positives = 205/466 (43%), Gaps = 40/466 (8%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLD--LMETIDKQREEMA 274
LR +Q + ++ L + + R +E Q+ EE+ +Q + L E +K+R +
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQ--EQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 275 KSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQL 334
+ ++ Q +E L + + + L +++ Q L E +++
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 335 SLSQRQAKELKLEQQEAA--ERESKLLRDLSAANEKNLLLQNQVDEL---ERKFRCQQEQ 389
R+ EL+ E+++ ERE + L++ + LQ + ++L ER+ R +QE
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 390 LFQTRQEMTSMSAELKMRAIQAEERLDMEK-RRCRQSLE-DSESLRIKEVEHMTRHLEES 447
Q R+E E ++ + E+R E+ R+CR+ E E ++ E R +E
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 448 EKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEE-------LIKAKSQARLEEQQ 500
E+ +E + + L EE + + L + + EEE L++ + + R +E++
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196
Query: 501 RLAHLEDKL---RLLAQARDEAQGACL------QQKQVVAE----AQTRVSQLGLQVEGL 547
R E++L + + RDE Q + L +++ V + + R ++ Q+E
Sbjct: 1197 RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256
Query: 548 RRRLEELQQELSL---KDQERVAEVSRVRVELQE----QNGRLQAELAAQEALREKAAAL 600
+ R + QQ+L + QER E R R + ++ + +L+ E + R++ +
Sbjct: 1257 QLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQE 1316
Query: 601 ERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQR 646
E+QL + + E +E++ E+ L+E E +R +E R
Sbjct: 1317 EKQL--LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360
Score = 58.2 bits (139), Expect = 2e-08
Identities = 97/463 (20%), Positives = 192/463 (41%), Gaps = 70/463 (15%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLM---ETIDKQREEMAKSSRASAARV 284
Q+ +E + + + +E Q+ EE+ +Q + + E ++R+E+ + R
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087
Query: 285 GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKEL 344
+ ++ L E + + Q E L +++ Q L E +++L R+ +E+
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEE-ELQQEEEQLLREEREKRRRQELERQYREEEEV 1146
Query: 345 KLEQQEAA--ERESKLLRDLSAANEKNLLLQNQVDEL--ERKFRCQQEQLFQTRQEMTSM 400
+ E+++ E E + ++L + LQ + ++L E + + +QE+ Q R+E
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206
Query: 401 SAELKMRAIQAEERLDME--------------KRRCR-------QSLEDSESLRIKEVEH 439
+ K R ++R D++ K C+ + LEDS+ LR ++ +
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQ-LRDRQSQQ 1265
Query: 440 MTRHL---------EESEKAMQER---------VQRLEAARLSLEEELSRVKAAALSERG 481
+HL E+ + Q+R ++R E + S+ + L E
Sbjct: 1266 DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLRE-- 1323
Query: 482 QAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+ EE+ + ++ + E+++L ++ L Q RD + R +L
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR---------------KFREEELR 1368
Query: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALE 601
Q +G R+ LEE Q+ L+ QER + + +L+ Q Q RE+ L
Sbjct: 1369 HQEQG-RKFLEEEQR---LRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLS 1424
Query: 602 RQLKVMASDHREALLDR-ESENASLREKLRLREAEIARIRDEE 643
RQ + E + R E E L E+ +LR+ + R+EE
Sbjct: 1425 RQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467
Score = 47.8 bits (112), Expect = 3e-05
Identities = 68/286 (23%), Positives = 118/286 (41%), Gaps = 49/286 (17%)
Query: 216 VLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAK 275
+L+ E+ Q+R F+E +E Q R+E+ ++F L E +R+E+ +
Sbjct: 1675 LLQEGEEQQLRRQERDRKFRE---------EEQQLRRQERERKF--LQEEQQLRRQELER 1723
Query: 276 SSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
R QL++ + +L+ E + E++ +L E++QL
Sbjct: 1724 KFREEE----QLRQETEQE---------QLRRQERYRKILEEE-----QLRPEREEQQLR 1765
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
+R K + E+Q ERE + LR E +RKFR ++EQL Q R+
Sbjct: 1766 RQERDRK-FREEEQLRQEREEQQLRS---------------QESDRKFR-EEEQLRQERE 1808
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKE---VEHMTRHLEESEKAMQ 452
E + + EE+L +E++ R E R +E + +R E+ +
Sbjct: 1809 EQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEE 1868
Query: 453 ERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEE 498
E+ +R E R EE + R + R E + + K RL E
Sbjct: 1869 EQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914
Score = 31.6 bits (70), Expect = 2.5
Identities = 52/212 (24%), Positives = 84/212 (39%), Gaps = 44/212 (20%)
Query: 466 EEELSRV--KAAALSERGQAEEELIKAKSQARLEE---QQRLAHLEDKLRLLAQARDEAQ 520
EE+ +R K + L +R Q E++ +LEE Q+R +++ R LA+ +++
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS- 155
Query: 521 GACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEEL---QQELSLKDQERVAEVSRVRVELQ 577
E Q R+ Q Q RR EEL +QE +++ R E +LQ
Sbjct: 156 -----------EKQERLEQRDRQ-----RRDEELWRQRQEWQEREERRAEEE-----QLQ 194
Query: 578 EQNGRLQAELAAQEALREKAAA--------------LERQLKVMASDHREALLDRESENA 623
G E +E LR + ERQ +V + + RE+
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254
Query: 624 SLREKLRLREAEIARIRDEEAQRASFLQNAVL 655
EKL+ E + R EE ++ L+ L
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 100 bits (248), Expect = 6e-21
Identities = 124/467 (26%), Positives = 213/467 (45%), Gaps = 53/467 (11%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQH---LREEKSKQFLDLMETIDKQRE 271
D LR+ EQA + + E + R + VQ EE ++Q +E +++ +
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK- 2015
Query: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
AK A R QE+ + A + +LQ E A A + Q+ + EL T +Q
Sbjct: 2016 --AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQ 2071
Query: 332 EQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF 391
EQ L Q + + + E+++ + AA + QV+E ER + +EQ
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-----RQVEEAERLKQSAEEQA- 2125
Query: 392 QTRQEMTSMSAELKMRAIQ-AEERLDMEKRRCRQ-SLEDSESLRIKEVEHMT----RHLE 445
Q R + + + +L+ A Q A R E+ RQ D+E + K+ T +E
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 446 ESEKAMQERVQRLEAARLSLEEELSRVKAAALS---ERGQAEEELIK--------AKSQA 494
+ ++ +++ + + L+EEL R+KA A +R Q EEEL +K +A
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 495 RLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEE- 553
R+E + R L DK ++EA+ + KQV EA R+S + LR+ EE
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAE----KMKQVAEEA-ARLSVAAQEAARLRQLAEED 2300
Query: 554 ------LQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLK 605
L +++ + + V E +R++ E + + Q ELA ++A L+E + +QL
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQLA 2358
Query: 606 VMASDHR---EALLDRESENASLREKLRLREAEIARIR---DEEAQR 646
+ EA R+ E ++ E+L+LR AE++R + +E+AQR
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Score = 96.7 bits (239), Expect = 6e-20
Identities = 111/442 (25%), Positives = 196/442 (44%), Gaps = 66/442 (14%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
++A +A Q L +E + + + ++ E+++Q +ET + E +S
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 277 SRAS-AARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
RAS A + QL+ +L E H + L+ + + A +E+ ++ A E E+
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-----AERELERWQ 1635
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
L +A L+L+ +E A+++S L+ A + Q +E ER+ R
Sbjct: 1636 LKANEALRLRLQAEEVAQQKS-----LAQAE-----AEKQKEEAEREAR----------- 1674
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERV 455
+ + +A++ E + E + RQ E + R+ + + R E+E+ Q+
Sbjct: 1675 ----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-- 1728
Query: 456 QRLEAARLSLEEELSRVK---AAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL 512
R LEEEL+R++ AAA +R + E EL K + A +E L
Sbjct: 1729 ------RQLLEEELARLQREAAAATQKRQELEAELAKVR-----------AEMEVLLASK 1771
Query: 513 AQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV---AEV 569
A+A +E++ + KQ + R +L + LR EE +++ L +++ AE
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 570 SRVRVELQEQNG---RLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLR 626
RV E G RL+ E A+ AL+EK A ER L+ +A D EA R E + +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENER-LRRLAED--EAFQRRRLEEQAAQ 1886
Query: 627 EKLRLRE--AEIARIRDEEAQR 646
K + E A++ + D E +R
Sbjct: 1887 HKADIEERLAQLRKASDSELER 1908
Score = 90.5 bits (223), Expect = 5e-18
Identities = 112/488 (22%), Positives = 220/488 (45%), Gaps = 52/488 (10%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQA---RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEM 273
L A+ +A + +E +A R L+++ R +Q I+++ ++
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Query: 274 AKSSRASAARV-GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE-- 330
K+S + R G +++ L +R + + A E A A + +LG + + AE
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958
Query: 331 ---QEQLSLSQRQAKELKLEQQEAA-ERESKLLRDLSAANEKNLLLQNQVDELER-KFRC 385
+EQ L + ++L E++ E E ++ + L+A E + ++E+ER K +
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 386 QQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLE 445
++ + + R E S + +L++ A++RL E++ +++ E + + + L+
Sbjct: 2019 EEARRLRERAEQES-ARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTLQ 2070
Query: 446 ESEKAMQERVQRLEAARLSLEE-ELSRVKA---AALSERGQAEEELIKA----KSQARLE 497
+ + + + EAAR + EE E +RV+A AA S R E E +K ++QAR +
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 498 EQQRLAHLEDKLRLLAQARDEAQGACLQQKQVV----------AEAQTR-VSQLGLQVEG 546
Q L + A R +A+ A L+QKQ AE R +Q+ ++
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190
Query: 547 LRRRLEELQQELSLKDQE------RVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL 600
LR +LEE + +L D+E E +R R +++E+ ++ ++ L+ + A
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250
Query: 601 ERQLKVMASDHREALLDRESEN----ASLREKLRLREAEIARIR----DEEAQRASFLQN 652
R L + D+ + L E+E A +L + E AR+R ++ AQ+ + +
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310
Query: 653 AVLAYVQA 660
+ +QA
Sbjct: 2311 MLKEKMQA 2318
Score = 85.5 bits (210), Expect = 1e-16
Identities = 131/534 (24%), Positives = 235/534 (44%), Gaps = 102/534 (19%)
Query: 223 AMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASA- 281
A H+Q + +E + + +EV REE + +I ++ +++ +SS A
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434
Query: 282 ARVGQLQEALNERHSI---INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQ 338
A+ Q + A R I I ++ +L+ TE +E + Q L AE ++ +Q
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-AQ 1493
Query: 339 RQAKELKLEQQEAAERE--------SKLLRDLSAANEKNLLLQN------QVDELERKFR 384
+A+ L+ + Q+ ++R+ S++ + AA EK LQ Q +E ER+ R
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553
Query: 385 CQQEQLFQTRQ--------------EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430
Q ++ + RQ E+ S A + Q E L E Q E++E
Sbjct: 1554 --QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1611
Query: 431 SLRIKEVEHMTRHLEESEKAMQE-RVQRLEAARLSLE-EELSRVKAAALSE--------- 479
R ++ R EE+E+ ++ +++ EA RL L+ EE+++ K+ A +E
Sbjct: 1612 R-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 480 -----RGQAEEELIKAK-----------------SQARLEEQQRLAHL-------EDKLR 510
RG+AEE+ ++ + +Q RL +Q L L E + +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 511 LLAQ--ARDEAQGACLQQKQVVAEAQTRVSQLGLQV-EGLRRRLEELQQELSLKDQERV- 566
LL + AR + + A QK+ EA+ + ++V + R EE + S K ++R+
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790
Query: 567 AEVSRVRVELQEQNGRLQA---------ELAAQEALREKAAALERQLKV----------M 607
AE R R EL E+ RL+A +LA ++A R++A A ER L +
Sbjct: 1791 AEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKLAAIGEATRL 1848
Query: 608 ASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQAS 661
++ AL ++E+EN LR + R+ ++ AQ + ++ + +AS
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Score = 81.6 bits (200), Expect = 2e-15
Identities = 108/450 (24%), Positives = 199/450 (44%), Gaps = 65/450 (14%)
Query: 232 TTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
T Q+ Q + + +Q + K LD E + + + E +++R ++V + ++
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAAR-QRSQVEEELFSV 2233
Query: 292 NERHSIINALKAKLQMTEAALALSEQK-----AQDLGELLATAEQEQLSLS---QRQAKE 343
+ ++ LKA+++ AL L ++ Q+ E + +E LS Q A+
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 344 LKLEQQEAAERES---KLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+L +++ A++ + K+L++ A ++ L+ + + L+++ QEQ + +++ M
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353
Query: 401 SAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI--------------------KEVEHM 440
+ +L + L+ E++R + ++E L++ K+ E +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 441 TRHLEESEKAMQER---VQRLEAARLSLEEELSRVKAAAL-----SERGQAEEELIKAKS 492
L +E A QE+ VQ LE R + + R++ A E+ Q E +L++ KS
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473
Query: 493 QAR--------LEEQQRL--AHLEDKLRLLAQAR----DEAQGACLQQKQVVAEAQTRVS 538
+ L+E Q L + L +K LL + R ++A+ L Q +V Q R
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533
Query: 539 Q--LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQ--EQNGRLQAELAAQEALR 594
Q Q+E R+RL +E + E V R + ELQ EQ R Q EL A+E R
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 595 EKAAALERQLKVMASDHREALLDRESENAS 624
L QL+++ HR AL E AS
Sbjct: 2594 -----LREQLQLLEEQHRAALAHSEEVTAS 2618
Score = 76.6 bits (187), Expect = 7e-14
Identities = 118/482 (24%), Positives = 204/482 (42%), Gaps = 64/482 (13%)
Query: 205 LDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLME 264
L + G +VLRA E+ + +Q T E +A L K LR + Q
Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK----LRAQAEAQ----QP 1144
Query: 265 TIDKQREEMAKSSRASAARVGQ-LQEALNERHSIINALKAK----LQMTEAALALSEQKA 319
T D R+E+ A VG+ LQ+ ER + + + L+ +A LA ++ +
Sbjct: 1145 TFDALRDELR-----GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1199
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKL----LRDLSAANEKNLLLQNQ 375
++L +L QL + A L Q+A R+ ++ L D A E+ Q
Sbjct: 1200 RELEQL-----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1254
Query: 376 VDELERKFRCQQE-QLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434
++E+ER +E Q F + EL++ +A+ + + SES+
Sbjct: 1255 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314
Query: 435 KEVEHMTRHLE-------------ESEKAMQERVQRLEAARLSLEEELSRVKAAALSERG 481
+ V+ T + E E+ + M+E + E R E L+ V+AA +R
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR- 1373
Query: 482 QAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+L +A +QA+ + ++ L+ +++ R+EA QQK+ + E ++ Q
Sbjct: 1374 ----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1429
Query: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQE-QNGRLQAELAAQEALREKAAAL 600
+ R E + L+ +E + V R+++E E Q G + EL A A E+A A
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEI-RVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1488
Query: 601 ERQLKVMASDHREALLDR---------------ESENASLREKLR-LREAEIARIRDEEA 644
+RQ + A R + D ++E + REK R L+ E R++ EEA
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548
Query: 645 QR 646
+R
Sbjct: 1549 ER 1550
Score = 72.0 bits (175), Expect = 2e-12
Identities = 107/446 (23%), Positives = 196/446 (43%), Gaps = 68/446 (15%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
D + +Q +Q T + + R +S E + L+ ++ M + EE A
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDA 2403
Query: 275 KSSRASAARVGQ----LQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE 330
+ R A +G+ + A E+ +++ L+ + Q S+ A+ L E +A E
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ-------SDHDAERLREAIAELE 2456
Query: 331 QEQLSLSQRQAKELKLEQQE-AAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQ 389
+E+ L Q++AK L+L+ +E ++ +LL++ A + L ++ + + ER ++ +
Sbjct: 2457 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 390 LFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEK 449
L Q Q+ + + +L+ + +++++ E++R S+E E EE +
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME--------EARRRQHEAEEGVR 2567
Query: 450 AMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQR--LAHLED 507
QE +Q+LE R EE L+E Q E ++ LEEQ R LAH E+
Sbjct: 2568 RKQEELQQLEQQRRQQEE--------LLAEENQRLREQLQL-----LEEQHRAALAHSEE 2614
Query: 508 -------KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSL 560
+ L RD G AEA+ S GL+ + +RL+E LS
Sbjct: 2615 VTASQVAATKTLPNGRDALDGP-------AAEAEPEHSFDGLRRKVSAQRLQE-AGILSA 2666
Query: 561 KDQERVA-------EVSR---VRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASD 610
++ +R+A E++R VR LQ ++ L A AAL+RQL ++
Sbjct: 2667 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL--LSPG 2724
Query: 611 HREALLDRESENASLREKLRLREAEI 636
LL+ ++ + L + +R R +
Sbjct: 2725 TALILLEAQAASGFLLDPVRNRRLTV 2750
Score = 34.7 bits (78), Expect = 0.29
Identities = 72/334 (21%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 285 GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKEL 344
G+L A+ ER + + +L+ + + + +A E L A+ + Q+
Sbjct: 371 GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD------ALLQSDVR 424
Query: 345 KLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQL----FQTRQEMTSM 400
L + +R ++ RDL A+ LL N V L+ Q EQ+ ++ + + ++
Sbjct: 425 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 484
Query: 401 SAELKMR-----AIQAEE--RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE 453
E +R A A + ++ ++ + R LEDS R+L++ ++E
Sbjct: 485 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDS----------TLRYLQDLLAWVEE 534
Query: 454 RVQRLEAARLSLEEELSRVKAAALSERG--QAEEELIKAKSQARLEEQQRLAHLEDKLRL 511
R++ A + +L V+A S RG Q+ EE +AR +E Q L R
Sbjct: 535 NQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ----LSPATR- 587
Query: 512 LAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSR 571
RD LQ +++ ++ R+ L E L + +EL +++ EV
Sbjct: 588 -GAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAAATKELMWLNEKEEEEVG- 641
Query: 572 VRVELQEQNGRLQAELAAQEALREKAAALERQLK 605
+ ++N + A+ + AL + E+++K
Sbjct: 642 --FDWSDRNTNMTAKKESYSALMRELELKEKKIK 673
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 100 bits (248), Expect = 6e-21
Identities = 124/467 (26%), Positives = 213/467 (45%), Gaps = 53/467 (11%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQH---LREEKSKQFLDLMETIDKQRE 271
D LR+ EQA + + E + R + VQ EE ++Q +E +++ +
Sbjct: 1961 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK- 2019
Query: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
AK A R QE+ + A + +LQ E A A + Q+ + EL T +Q
Sbjct: 2020 --AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQ 2075
Query: 332 EQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF 391
EQ L Q + + + E+++ + AA + QV+E ER + +EQ
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-----RQVEEAERLKQSAEEQA- 2129
Query: 392 QTRQEMTSMSAELKMRAIQ-AEERLDMEKRRCRQ-SLEDSESLRIKEVEHMT----RHLE 445
Q R + + + +L+ A Q A R E+ RQ D+E + K+ T +E
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189
Query: 446 ESEKAMQERVQRLEAARLSLEEELSRVKAAALS---ERGQAEEELIK--------AKSQA 494
+ ++ +++ + + L+EEL R+KA A +R Q EEEL +K +A
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2249
Query: 495 RLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEE- 553
R+E + R L DK ++EA+ + KQV EA R+S + LR+ EE
Sbjct: 2250 RIEAENRALILRDKDNTQRFLQEEAE----KMKQVAEEA-ARLSVAAQEAARLRQLAEED 2304
Query: 554 ------LQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLK 605
L +++ + + V E +R++ E + + Q ELA ++A L+E + +QL
Sbjct: 2305 LAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQLA 2362
Query: 606 VMASDHR---EALLDRESENASLREKLRLREAEIARIR---DEEAQR 646
+ EA R+ E ++ E+L+LR AE++R + +E+AQR
Sbjct: 2363 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409
Score = 96.7 bits (239), Expect = 6e-20
Identities = 111/442 (25%), Positives = 196/442 (44%), Gaps = 66/442 (14%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
++A +A Q L +E + + + ++ E+++Q +ET + E +S
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584
Query: 277 SRAS-AARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
RAS A + QL+ +L E H + L+ + + A +E+ ++ A E E+
Sbjct: 1585 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-----AERELERWQ 1639
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
L +A L+L+ +E A+++S L+ A + Q +E ER+ R
Sbjct: 1640 LKANEALRLRLQAEEVAQQKS-----LAQAE-----AEKQKEEAEREAR----------- 1678
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERV 455
+ + +A++ E + E + RQ E + R+ + + R E+E+ Q+
Sbjct: 1679 ----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-- 1732
Query: 456 QRLEAARLSLEEELSRVK---AAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL 512
R LEEEL+R++ AAA +R + E EL K + A +E L
Sbjct: 1733 ------RQLLEEELARLQREAAAATQKRQELEAELAKVR-----------AEMEVLLASK 1775
Query: 513 AQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV---AEV 569
A+A +E++ + KQ + R +L + LR EE +++ L +++ AE
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835
Query: 570 SRVRVELQEQNG---RLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLR 626
RV E G RL+ E A+ AL+EK A ER L+ +A D EA R E + +
Sbjct: 1836 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENER-LRRLAED--EAFQRRRLEEQAAQ 1890
Query: 627 EKLRLRE--AEIARIRDEEAQR 646
K + E A++ + D E +R
Sbjct: 1891 HKADIEERLAQLRKASDSELER 1912
Score = 90.5 bits (223), Expect = 5e-18
Identities = 112/488 (22%), Positives = 220/488 (45%), Gaps = 52/488 (10%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQA---RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEM 273
L A+ +A + +E +A R L+++ R +Q I+++ ++
Sbjct: 1843 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1902
Query: 274 AKSSRASAARV-GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE-- 330
K+S + R G +++ L +R + + A E A A + +LG + + AE
Sbjct: 1903 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1962
Query: 331 ---QEQLSLSQRQAKELKLEQQEAA-ERESKLLRDLSAANEKNLLLQNQVDELER-KFRC 385
+EQ L + ++L E++ E E ++ + L+A E + ++E+ER K +
Sbjct: 1963 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2022
Query: 386 QQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLE 445
++ + + R E S + +L++ A++RL E++ +++ E + + + L+
Sbjct: 2023 EEARRLRERAEQES-ARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTLQ 2074
Query: 446 ESEKAMQERVQRLEAARLSLEE-ELSRVKA---AALSERGQAEEELIKA----KSQARLE 497
+ + + + EAAR + EE E +RV+A AA S R E E +K ++QAR +
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134
Query: 498 EQQRLAHLEDKLRLLAQARDEAQGACLQQKQVV----------AEAQTR-VSQLGLQVEG 546
Q L + A R +A+ A L+QKQ AE R +Q+ ++
Sbjct: 2135 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2194
Query: 547 LRRRLEELQQELSLKDQE------RVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL 600
LR +LEE + +L D+E E +R R +++E+ ++ ++ L+ + A
Sbjct: 2195 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2254
Query: 601 ERQLKVMASDHREALLDRESEN----ASLREKLRLREAEIARIR----DEEAQRASFLQN 652
R L + D+ + L E+E A +L + E AR+R ++ AQ+ + +
Sbjct: 2255 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2314
Query: 653 AVLAYVQA 660
+ +QA
Sbjct: 2315 MLKEKMQA 2322
Score = 85.5 bits (210), Expect = 1e-16
Identities = 131/534 (24%), Positives = 235/534 (44%), Gaps = 102/534 (19%)
Query: 223 AMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASA- 281
A H+Q + +E + + +EV REE + +I ++ +++ +SS A
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1438
Query: 282 ARVGQLQEALNERHSI---INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQ 338
A+ Q + A R I I ++ +L+ TE +E + Q L AE ++ +Q
Sbjct: 1439 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-AQ 1497
Query: 339 RQAKELKLEQQEAAERE--------SKLLRDLSAANEKNLLLQN------QVDELERKFR 384
+A+ L+ + Q+ ++R+ S++ + AA EK LQ Q +E ER+ R
Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1557
Query: 385 CQQEQLFQTRQ--------------EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430
Q ++ + RQ E+ S A + Q E L E Q E++E
Sbjct: 1558 --QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1615
Query: 431 SLRIKEVEHMTRHLEESEKAMQE-RVQRLEAARLSLE-EELSRVKAAALSE--------- 479
R ++ R EE+E+ ++ +++ EA RL L+ EE+++ K+ A +E
Sbjct: 1616 R-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674
Query: 480 -----RGQAEEELIKAK-----------------SQARLEEQQRLAHL-------EDKLR 510
RG+AEE+ ++ + +Q RL +Q L L E + +
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734
Query: 511 LLAQ--ARDEAQGACLQQKQVVAEAQTRVSQLGLQV-EGLRRRLEELQQELSLKDQERV- 566
LL + AR + + A QK+ EA+ + ++V + R EE + S K ++R+
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1794
Query: 567 AEVSRVRVELQEQNGRLQA---------ELAAQEALREKAAALERQLKV----------M 607
AE R R EL E+ RL+A +LA ++A R++A A ER L +
Sbjct: 1795 AEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKLAAIGEATRL 1852
Query: 608 ASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQAS 661
++ AL ++E+EN LR + R+ ++ AQ + ++ + +AS
Sbjct: 1853 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1906
Score = 81.6 bits (200), Expect = 2e-15
Identities = 108/450 (24%), Positives = 199/450 (44%), Gaps = 65/450 (14%)
Query: 232 TTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
T Q+ Q + + +Q + K LD E + + + E +++R ++V + ++
Sbjct: 2181 TLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAAR-QRSQVEEELFSV 2237
Query: 292 NERHSIINALKAKLQMTEAALALSEQK-----AQDLGELLATAEQEQLSLS---QRQAKE 343
+ ++ LKA+++ AL L ++ Q+ E + +E LS Q A+
Sbjct: 2238 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2297
Query: 344 LKLEQQEAAERES---KLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+L +++ A++ + K+L++ A ++ L+ + + L+++ QEQ + +++ M
Sbjct: 2298 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2357
Query: 401 SAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI--------------------KEVEHM 440
+ +L + L+ E++R + ++E L++ K+ E +
Sbjct: 2358 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2417
Query: 441 TRHLEESEKAMQER---VQRLEAARLSLEEELSRVKAAAL-----SERGQAEEELIKAKS 492
L +E A QE+ VQ LE R + + R++ A E+ Q E +L++ KS
Sbjct: 2418 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2477
Query: 493 QAR--------LEEQQRL--AHLEDKLRLLAQAR----DEAQGACLQQKQVVAEAQTRVS 538
+ L+E Q L + L +K LL + R ++A+ L Q +V Q R
Sbjct: 2478 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2537
Query: 539 Q--LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQ--EQNGRLQAELAAQEALR 594
Q Q+E R+RL +E + E V R + ELQ EQ R Q EL A+E R
Sbjct: 2538 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2597
Query: 595 EKAAALERQLKVMASDHREALLDRESENAS 624
L QL+++ HR AL E AS
Sbjct: 2598 -----LREQLQLLEEQHRAALAHSEEVTAS 2622
Score = 76.6 bits (187), Expect = 7e-14
Identities = 118/482 (24%), Positives = 204/482 (42%), Gaps = 64/482 (13%)
Query: 205 LDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLME 264
L + G +VLRA E+ + +Q T E +A L K LR + Q
Sbjct: 1097 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK----LRAQAEAQ----QP 1148
Query: 265 TIDKQREEMAKSSRASAARVGQ-LQEALNERHSIINALKAK----LQMTEAALALSEQKA 319
T D R+E+ A VG+ LQ+ ER + + + L+ +A LA ++ +
Sbjct: 1149 TFDALRDELR-----GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1203
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKL----LRDLSAANEKNLLLQNQ 375
++L +L QL + A L Q+A R+ ++ L D A E+ Q
Sbjct: 1204 RELEQL-----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1258
Query: 376 VDELERKFRCQQE-QLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434
++E+ER +E Q F + EL++ +A+ + + SES+
Sbjct: 1259 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1318
Query: 435 KEVEHMTRHLE-------------ESEKAMQERVQRLEAARLSLEEELSRVKAAALSERG 481
+ V+ T + E E+ + M+E + E R E L+ V+AA +R
Sbjct: 1319 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR- 1377
Query: 482 QAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+L +A +QA+ + ++ L+ +++ R+EA QQK+ + E ++ Q
Sbjct: 1378 ----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1433
Query: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQE-QNGRLQAELAAQEALREKAAAL 600
+ R E + L+ +E + V R+++E E Q G + EL A A E+A A
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEI-RVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1492
Query: 601 ERQLKVMASDHREALLDR---------------ESENASLREKLR-LREAEIARIRDEEA 644
+RQ + A R + D ++E + REK R L+ E R++ EEA
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552
Query: 645 QR 646
+R
Sbjct: 1553 ER 1554
Score = 72.0 bits (175), Expect = 2e-12
Identities = 107/446 (23%), Positives = 196/446 (43%), Gaps = 68/446 (15%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
D + +Q +Q T + + R +S E + L+ ++ M + EE A
Sbjct: 2353 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDA 2407
Query: 275 KSSRASAARVGQ----LQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE 330
+ R A +G+ + A E+ +++ L+ + Q S+ A+ L E +A E
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ-------SDHDAERLREAIAELE 2460
Query: 331 QEQLSLSQRQAKELKLEQQE-AAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQ 389
+E+ L Q++AK L+L+ +E ++ +LL++ A + L ++ + + ER ++ +
Sbjct: 2461 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2519
Query: 390 LFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEK 449
L Q Q+ + + +L+ + +++++ E++R S+E E EE +
Sbjct: 2520 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME--------EARRRQHEAEEGVR 2571
Query: 450 AMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQR--LAHLED 507
QE +Q+LE R EE L+E Q E ++ LEEQ R LAH E+
Sbjct: 2572 RKQEELQQLEQQRRQQEE--------LLAEENQRLREQLQL-----LEEQHRAALAHSEE 2618
Query: 508 -------KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSL 560
+ L RD G AEA+ S GL+ + +RL+E LS
Sbjct: 2619 VTASQVAATKTLPNGRDALDGP-------AAEAEPEHSFDGLRRKVSAQRLQE-AGILSA 2670
Query: 561 KDQERVA-------EVSR---VRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASD 610
++ +R+A E++R VR LQ ++ L A AAL+RQL ++
Sbjct: 2671 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL--LSPG 2728
Query: 611 HREALLDRESENASLREKLRLREAEI 636
LL+ ++ + L + +R R +
Sbjct: 2729 TALILLEAQAASGFLLDPVRNRRLTV 2754
Score = 34.7 bits (78), Expect = 0.29
Identities = 72/334 (21%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 285 GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKEL 344
G+L A+ ER + + +L+ + + + +A E L A+ + Q+
Sbjct: 375 GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD------ALLQSDVR 428
Query: 345 KLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQL----FQTRQEMTSM 400
L + +R ++ RDL A+ LL N V L+ Q EQ+ ++ + + ++
Sbjct: 429 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 488
Query: 401 SAELKMR-----AIQAEE--RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE 453
E +R A A + ++ ++ + R LEDS R+L++ ++E
Sbjct: 489 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDS----------TLRYLQDLLAWVEE 538
Query: 454 RVQRLEAARLSLEEELSRVKAAALSERG--QAEEELIKAKSQARLEEQQRLAHLEDKLRL 511
R++ A + +L V+A S RG Q+ EE +AR +E Q L R
Sbjct: 539 NQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ----LSPATR- 591
Query: 512 LAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSR 571
RD LQ +++ ++ R+ L E L + +EL +++ EV
Sbjct: 592 -GAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAAATKELMWLNEKEEEEVG- 645
Query: 572 VRVELQEQNGRLQAELAAQEALREKAAALERQLK 605
+ ++N + A+ + AL + E+++K
Sbjct: 646 --FDWSDRNTNMTAKKESYSALMRELELKEKKIK 677
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 100 bits (248), Expect = 6e-21
Identities = 124/467 (26%), Positives = 213/467 (45%), Gaps = 53/467 (11%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQH---LREEKSKQFLDLMETIDKQRE 271
D LR+ EQA + + E + R + VQ EE ++Q +E +++ +
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK- 2015
Query: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
AK A R QE+ + A + +LQ E A A + Q+ + EL T +Q
Sbjct: 2016 --AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQ 2071
Query: 332 EQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF 391
EQ L Q + + + E+++ + AA + QV+E ER + +EQ
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-----RQVEEAERLKQSAEEQA- 2125
Query: 392 QTRQEMTSMSAELKMRAIQ-AEERLDMEKRRCRQ-SLEDSESLRIKEVEHMT----RHLE 445
Q R + + + +L+ A Q A R E+ RQ D+E + K+ T +E
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185
Query: 446 ESEKAMQERVQRLEAARLSLEEELSRVKAAALS---ERGQAEEELIK--------AKSQA 494
+ ++ +++ + + L+EEL R+KA A +R Q EEEL +K +A
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245
Query: 495 RLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEE- 553
R+E + R L DK ++EA+ + KQV EA R+S + LR+ EE
Sbjct: 2246 RIEAENRALILRDKDNTQRFLQEEAE----KMKQVAEEA-ARLSVAAQEAARLRQLAEED 2300
Query: 554 ------LQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLK 605
L +++ + + V E +R++ E + + Q ELA ++A L+E + +QL
Sbjct: 2301 LAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQLA 2358
Query: 606 VMASDHR---EALLDRESENASLREKLRLREAEIARIR---DEEAQR 646
+ EA R+ E ++ E+L+LR AE++R + +E+AQR
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Score = 96.7 bits (239), Expect = 6e-20
Identities = 111/442 (25%), Positives = 196/442 (44%), Gaps = 66/442 (14%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
++A +A Q L +E + + + ++ E+++Q +ET + E +S
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 277 SRAS-AARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
RAS A + QL+ +L E H + L+ + + A +E+ ++ A E E+
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-----AERELERWQ 1635
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
L +A L+L+ +E A+++S L+ A + Q +E ER+ R
Sbjct: 1636 LKANEALRLRLQAEEVAQQKS-----LAQAE-----AEKQKEEAEREAR----------- 1674
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERV 455
+ + +A++ E + E + RQ E + R+ + + R E+E+ Q+
Sbjct: 1675 ----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-- 1728
Query: 456 QRLEAARLSLEEELSRVK---AAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL 512
R LEEEL+R++ AAA +R + E EL K + A +E L
Sbjct: 1729 ------RQLLEEELARLQREAAAATQKRQELEAELAKVR-----------AEMEVLLASK 1771
Query: 513 AQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV---AEV 569
A+A +E++ + KQ + R +L + LR EE +++ L +++ AE
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 570 SRVRVELQEQNG---RLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLR 626
RV E G RL+ E A+ AL+EK A ER L+ +A D EA R E + +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENER-LRRLAED--EAFQRRRLEEQAAQ 1886
Query: 627 EKLRLRE--AEIARIRDEEAQR 646
K + E A++ + D E +R
Sbjct: 1887 HKADIEERLAQLRKASDSELER 1908
Score = 90.5 bits (223), Expect = 5e-18
Identities = 112/488 (22%), Positives = 220/488 (45%), Gaps = 52/488 (10%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQA---RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEM 273
L A+ +A + +E +A R L+++ R +Q I+++ ++
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Query: 274 AKSSRASAARV-GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE-- 330
K+S + R G +++ L +R + + A E A A + +LG + + AE
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1958
Query: 331 ---QEQLSLSQRQAKELKLEQQEAA-ERESKLLRDLSAANEKNLLLQNQVDELER-KFRC 385
+EQ L + ++L E++ E E ++ + L+A E + ++E+ER K +
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2018
Query: 386 QQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLE 445
++ + + R E S + +L++ A++RL E++ +++ E + + + L+
Sbjct: 2019 EEARRLRERAEQES-ARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTLQ 2070
Query: 446 ESEKAMQERVQRLEAARLSLEE-ELSRVKA---AALSERGQAEEELIKA----KSQARLE 497
+ + + + EAAR + EE E +RV+A AA S R E E +K ++QAR +
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 498 EQQRLAHLEDKLRLLAQARDEAQGACLQQKQVV----------AEAQTR-VSQLGLQVEG 546
Q L + A R +A+ A L+QKQ AE R +Q+ ++
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190
Query: 547 LRRRLEELQQELSLKDQE------RVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL 600
LR +LEE + +L D+E E +R R +++E+ ++ ++ L+ + A
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2250
Query: 601 ERQLKVMASDHREALLDRESEN----ASLREKLRLREAEIARIR----DEEAQRASFLQN 652
R L + D+ + L E+E A +L + E AR+R ++ AQ+ + +
Sbjct: 2251 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2310
Query: 653 AVLAYVQA 660
+ +QA
Sbjct: 2311 MLKEKMQA 2318
Score = 85.5 bits (210), Expect = 1e-16
Identities = 131/534 (24%), Positives = 235/534 (44%), Gaps = 102/534 (19%)
Query: 223 AMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASA- 281
A H+Q + +E + + +EV REE + +I ++ +++ +SS A
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1434
Query: 282 ARVGQLQEALNERHSI---INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQ 338
A+ Q + A R I I ++ +L+ TE +E + Q L AE ++ +Q
Sbjct: 1435 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-AQ 1493
Query: 339 RQAKELKLEQQEAAERE--------SKLLRDLSAANEKNLLLQN------QVDELERKFR 384
+A+ L+ + Q+ ++R+ S++ + AA EK LQ Q +E ER+ R
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1553
Query: 385 CQQEQLFQTRQ--------------EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430
Q ++ + RQ E+ S A + Q E L E Q E++E
Sbjct: 1554 --QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1611
Query: 431 SLRIKEVEHMTRHLEESEKAMQE-RVQRLEAARLSLE-EELSRVKAAALSE--------- 479
R ++ R EE+E+ ++ +++ EA RL L+ EE+++ K+ A +E
Sbjct: 1612 R-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670
Query: 480 -----RGQAEEELIKAK-----------------SQARLEEQQRLAHL-------EDKLR 510
RG+AEE+ ++ + +Q RL +Q L L E + +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730
Query: 511 LLAQ--ARDEAQGACLQQKQVVAEAQTRVSQLGLQV-EGLRRRLEELQQELSLKDQERV- 566
LL + AR + + A QK+ EA+ + ++V + R EE + S K ++R+
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790
Query: 567 AEVSRVRVELQEQNGRLQA---------ELAAQEALREKAAALERQLKV----------M 607
AE R R EL E+ RL+A +LA ++A R++A A ER L +
Sbjct: 1791 AEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKLAAIGEATRL 1848
Query: 608 ASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQAS 661
++ AL ++E+EN LR + R+ ++ AQ + ++ + +AS
Sbjct: 1849 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Score = 81.6 bits (200), Expect = 2e-15
Identities = 108/450 (24%), Positives = 199/450 (44%), Gaps = 65/450 (14%)
Query: 232 TTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
T Q+ Q + + +Q + K LD E + + + E +++R ++V + ++
Sbjct: 2177 TLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAAR-QRSQVEEELFSV 2233
Query: 292 NERHSIINALKAKLQMTEAALALSEQK-----AQDLGELLATAEQEQLSLS---QRQAKE 343
+ ++ LKA+++ AL L ++ Q+ E + +E LS Q A+
Sbjct: 2234 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2293
Query: 344 LKLEQQEAAERES---KLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+L +++ A++ + K+L++ A ++ L+ + + L+++ QEQ + +++ M
Sbjct: 2294 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2353
Query: 401 SAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI--------------------KEVEHM 440
+ +L + L+ E++R + ++E L++ K+ E +
Sbjct: 2354 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2413
Query: 441 TRHLEESEKAMQER---VQRLEAARLSLEEELSRVKAAAL-----SERGQAEEELIKAKS 492
L +E A QE+ VQ LE R + + R++ A E+ Q E +L++ KS
Sbjct: 2414 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2473
Query: 493 QAR--------LEEQQRL--AHLEDKLRLLAQAR----DEAQGACLQQKQVVAEAQTRVS 538
+ L+E Q L + L +K LL + R ++A+ L Q +V Q R
Sbjct: 2474 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2533
Query: 539 Q--LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQ--EQNGRLQAELAAQEALR 594
Q Q+E R+RL +E + E V R + ELQ EQ R Q EL A+E R
Sbjct: 2534 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2593
Query: 595 EKAAALERQLKVMASDHREALLDRESENAS 624
L QL+++ HR AL E AS
Sbjct: 2594 -----LREQLQLLEEQHRAALAHSEEVTAS 2618
Score = 76.6 bits (187), Expect = 7e-14
Identities = 118/482 (24%), Positives = 204/482 (42%), Gaps = 64/482 (13%)
Query: 205 LDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLME 264
L + G +VLRA E+ + +Q T E +A L K LR + Q
Sbjct: 1093 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK----LRAQAEAQ----QP 1144
Query: 265 TIDKQREEMAKSSRASAARVGQ-LQEALNERHSIINALKAK----LQMTEAALALSEQKA 319
T D R+E+ A VG+ LQ+ ER + + + L+ +A LA ++ +
Sbjct: 1145 TFDALRDELR-----GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1199
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKL----LRDLSAANEKNLLLQNQ 375
++L +L QL + A L Q+A R+ ++ L D A E+ Q
Sbjct: 1200 RELEQL-----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1254
Query: 376 VDELERKFRCQQE-QLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434
++E+ER +E Q F + EL++ +A+ + + SES+
Sbjct: 1255 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314
Query: 435 KEVEHMTRHLE-------------ESEKAMQERVQRLEAARLSLEEELSRVKAAALSERG 481
+ V+ T + E E+ + M+E + E R E L+ V+AA +R
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR- 1373
Query: 482 QAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+L +A +QA+ + ++ L+ +++ R+EA QQK+ + E ++ Q
Sbjct: 1374 ----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1429
Query: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQE-QNGRLQAELAAQEALREKAAAL 600
+ R E + L+ +E + V R+++E E Q G + EL A A E+A A
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEI-RVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1488
Query: 601 ERQLKVMASDHREALLDR---------------ESENASLREKLR-LREAEIARIRDEEA 644
+RQ + A R + D ++E + REK R L+ E R++ EEA
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548
Query: 645 QR 646
+R
Sbjct: 1549 ER 1550
Score = 72.0 bits (175), Expect = 2e-12
Identities = 107/446 (23%), Positives = 196/446 (43%), Gaps = 68/446 (15%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
D + +Q +Q T + + R +S E + L+ ++ M + EE A
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDA 2403
Query: 275 KSSRASAARVGQ----LQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE 330
+ R A +G+ + A E+ +++ L+ + Q S+ A+ L E +A E
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ-------SDHDAERLREAIAELE 2456
Query: 331 QEQLSLSQRQAKELKLEQQE-AAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQ 389
+E+ L Q++AK L+L+ +E ++ +LL++ A + L ++ + + ER ++ +
Sbjct: 2457 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 390 LFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEK 449
L Q Q+ + + +L+ + +++++ E++R S+E E EE +
Sbjct: 2516 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME--------EARRRQHEAEEGVR 2567
Query: 450 AMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQR--LAHLED 507
QE +Q+LE R EE L+E Q E ++ LEEQ R LAH E+
Sbjct: 2568 RKQEELQQLEQQRRQQEE--------LLAEENQRLREQLQL-----LEEQHRAALAHSEE 2614
Query: 508 -------KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSL 560
+ L RD G AEA+ S GL+ + +RL+E LS
Sbjct: 2615 VTASQVAATKTLPNGRDALDGP-------AAEAEPEHSFDGLRRKVSAQRLQE-AGILSA 2666
Query: 561 KDQERVA-------EVSR---VRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASD 610
++ +R+A E++R VR LQ ++ L A AAL+RQL ++
Sbjct: 2667 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL--LSPG 2724
Query: 611 HREALLDRESENASLREKLRLREAEI 636
LL+ ++ + L + +R R +
Sbjct: 2725 TALILLEAQAASGFLLDPVRNRRLTV 2750
Score = 34.7 bits (78), Expect = 0.29
Identities = 72/334 (21%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 285 GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKEL 344
G+L A+ ER + + +L+ + + + +A E L A+ + Q+
Sbjct: 371 GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD------ALLQSDVR 424
Query: 345 KLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQL----FQTRQEMTSM 400
L + +R ++ RDL A+ LL N V L+ Q EQ+ ++ + + ++
Sbjct: 425 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 484
Query: 401 SAELKMR-----AIQAEE--RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE 453
E +R A A + ++ ++ + R LEDS R+L++ ++E
Sbjct: 485 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDS----------TLRYLQDLLAWVEE 534
Query: 454 RVQRLEAARLSLEEELSRVKAAALSERG--QAEEELIKAKSQARLEEQQRLAHLEDKLRL 511
R++ A + +L V+A S RG Q+ EE +AR +E Q L R
Sbjct: 535 NQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ----LSPATR- 587
Query: 512 LAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSR 571
RD LQ +++ ++ R+ L E L + +EL +++ EV
Sbjct: 588 -GAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAAATKELMWLNEKEEEEVG- 641
Query: 572 VRVELQEQNGRLQAELAAQEALREKAAALERQLK 605
+ ++N + A+ + AL + E+++K
Sbjct: 642 --FDWSDRNTNMTAKKESYSALMRELELKEKKIK 673
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 100 bits (248), Expect = 6e-21
Identities = 124/467 (26%), Positives = 213/467 (45%), Gaps = 53/467 (11%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQH---LREEKSKQFLDLMETIDKQRE 271
D LR+ EQA + + E + R + VQ EE ++Q +E +++ +
Sbjct: 1925 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK- 1983
Query: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
AK A R QE+ + A + +LQ E A A + Q+ + EL T +Q
Sbjct: 1984 --AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQ 2039
Query: 332 EQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF 391
EQ L Q + + + E+++ + AA + QV+E ER + +EQ
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-----RQVEEAERLKQSAEEQA- 2093
Query: 392 QTRQEMTSMSAELKMRAIQ-AEERLDMEKRRCRQ-SLEDSESLRIKEVEHMT----RHLE 445
Q R + + + +L+ A Q A R E+ RQ D+E + K+ T +E
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153
Query: 446 ESEKAMQERVQRLEAARLSLEEELSRVKAAALS---ERGQAEEELIK--------AKSQA 494
+ ++ +++ + + L+EEL R+KA A +R Q EEEL +K +A
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2213
Query: 495 RLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEE- 553
R+E + R L DK ++EA+ + KQV EA R+S + LR+ EE
Sbjct: 2214 RIEAENRALILRDKDNTQRFLQEEAE----KMKQVAEEA-ARLSVAAQEAARLRQLAEED 2268
Query: 554 ------LQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLK 605
L +++ + + V E +R++ E + + Q ELA ++A L+E + +QL
Sbjct: 2269 LAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQLA 2326
Query: 606 VMASDHR---EALLDRESENASLREKLRLREAEIARIR---DEEAQR 646
+ EA R+ E ++ E+L+LR AE++R + +E+AQR
Sbjct: 2327 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373
Score = 96.7 bits (239), Expect = 6e-20
Identities = 111/442 (25%), Positives = 196/442 (44%), Gaps = 66/442 (14%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
++A +A Q L +E + + + ++ E+++Q +ET + E +S
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548
Query: 277 SRAS-AARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
RAS A + QL+ +L E H + L+ + + A +E+ ++ A E E+
Sbjct: 1549 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-----AERELERWQ 1603
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
L +A L+L+ +E A+++S L+ A + Q +E ER+ R
Sbjct: 1604 LKANEALRLRLQAEEVAQQKS-----LAQAE-----AEKQKEEAEREAR----------- 1642
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERV 455
+ + +A++ E + E + RQ E + R+ + + R E+E+ Q+
Sbjct: 1643 ----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-- 1696
Query: 456 QRLEAARLSLEEELSRVK---AAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL 512
R LEEEL+R++ AAA +R + E EL K + A +E L
Sbjct: 1697 ------RQLLEEELARLQREAAAATQKRQELEAELAKVR-----------AEMEVLLASK 1739
Query: 513 AQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV---AEV 569
A+A +E++ + KQ + R +L + LR EE +++ L +++ AE
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799
Query: 570 SRVRVELQEQNG---RLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLR 626
RV E G RL+ E A+ AL+EK A ER L+ +A D EA R E + +
Sbjct: 1800 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENER-LRRLAED--EAFQRRRLEEQAAQ 1854
Query: 627 EKLRLRE--AEIARIRDEEAQR 646
K + E A++ + D E +R
Sbjct: 1855 HKADIEERLAQLRKASDSELER 1876
Score = 90.5 bits (223), Expect = 5e-18
Identities = 112/488 (22%), Positives = 220/488 (45%), Gaps = 52/488 (10%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQA---RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEM 273
L A+ +A + +E +A R L+++ R +Q I+++ ++
Sbjct: 1807 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1866
Query: 274 AKSSRASAARV-GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE-- 330
K+S + R G +++ L +R + + A E A A + +LG + + AE
Sbjct: 1867 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1926
Query: 331 ---QEQLSLSQRQAKELKLEQQEAA-ERESKLLRDLSAANEKNLLLQNQVDELER-KFRC 385
+EQ L + ++L E++ E E ++ + L+A E + ++E+ER K +
Sbjct: 1927 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1986
Query: 386 QQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLE 445
++ + + R E S + +L++ A++RL E++ +++ E + + + L+
Sbjct: 1987 EEARRLRERAEQES-ARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTLQ 2038
Query: 446 ESEKAMQERVQRLEAARLSLEE-ELSRVKA---AALSERGQAEEELIKA----KSQARLE 497
+ + + + EAAR + EE E +RV+A AA S R E E +K ++QAR +
Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098
Query: 498 EQQRLAHLEDKLRLLAQARDEAQGACLQQKQVV----------AEAQTR-VSQLGLQVEG 546
Q L + A R +A+ A L+QKQ AE R +Q+ ++
Sbjct: 2099 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2158
Query: 547 LRRRLEELQQELSLKDQE------RVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL 600
LR +LEE + +L D+E E +R R +++E+ ++ ++ L+ + A
Sbjct: 2159 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2218
Query: 601 ERQLKVMASDHREALLDRESEN----ASLREKLRLREAEIARIR----DEEAQRASFLQN 652
R L + D+ + L E+E A +L + E AR+R ++ AQ+ + +
Sbjct: 2219 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2278
Query: 653 AVLAYVQA 660
+ +QA
Sbjct: 2279 MLKEKMQA 2286
Score = 85.5 bits (210), Expect = 1e-16
Identities = 131/534 (24%), Positives = 235/534 (44%), Gaps = 102/534 (19%)
Query: 223 AMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASA- 281
A H+Q + +E + + +EV REE + +I ++ +++ +SS A
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1402
Query: 282 ARVGQLQEALNERHSI---INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQ 338
A+ Q + A R I I ++ +L+ TE +E + Q L AE ++ +Q
Sbjct: 1403 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-AQ 1461
Query: 339 RQAKELKLEQQEAAERE--------SKLLRDLSAANEKNLLLQN------QVDELERKFR 384
+A+ L+ + Q+ ++R+ S++ + AA EK LQ Q +E ER+ R
Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1521
Query: 385 CQQEQLFQTRQ--------------EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430
Q ++ + RQ E+ S A + Q E L E Q E++E
Sbjct: 1522 --QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1579
Query: 431 SLRIKEVEHMTRHLEESEKAMQE-RVQRLEAARLSLE-EELSRVKAAALSE--------- 479
R ++ R EE+E+ ++ +++ EA RL L+ EE+++ K+ A +E
Sbjct: 1580 R-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638
Query: 480 -----RGQAEEELIKAK-----------------SQARLEEQQRLAHL-------EDKLR 510
RG+AEE+ ++ + +Q RL +Q L L E + +
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698
Query: 511 LLAQ--ARDEAQGACLQQKQVVAEAQTRVSQLGLQV-EGLRRRLEELQQELSLKDQERV- 566
LL + AR + + A QK+ EA+ + ++V + R EE + S K ++R+
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1758
Query: 567 AEVSRVRVELQEQNGRLQA---------ELAAQEALREKAAALERQLKV----------M 607
AE R R EL E+ RL+A +LA ++A R++A A ER L +
Sbjct: 1759 AEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKLAAIGEATRL 1816
Query: 608 ASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQAS 661
++ AL ++E+EN LR + R+ ++ AQ + ++ + +AS
Sbjct: 1817 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1870
Score = 81.6 bits (200), Expect = 2e-15
Identities = 108/450 (24%), Positives = 199/450 (44%), Gaps = 65/450 (14%)
Query: 232 TTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
T Q+ Q + + +Q + K LD E + + + E +++R ++V + ++
Sbjct: 2145 TLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAAR-QRSQVEEELFSV 2201
Query: 292 NERHSIINALKAKLQMTEAALALSEQK-----AQDLGELLATAEQEQLSLS---QRQAKE 343
+ ++ LKA+++ AL L ++ Q+ E + +E LS Q A+
Sbjct: 2202 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2261
Query: 344 LKLEQQEAAERES---KLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+L +++ A++ + K+L++ A ++ L+ + + L+++ QEQ + +++ M
Sbjct: 2262 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2321
Query: 401 SAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI--------------------KEVEHM 440
+ +L + L+ E++R + ++E L++ K+ E +
Sbjct: 2322 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2381
Query: 441 TRHLEESEKAMQER---VQRLEAARLSLEEELSRVKAAAL-----SERGQAEEELIKAKS 492
L +E A QE+ VQ LE R + + R++ A E+ Q E +L++ KS
Sbjct: 2382 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2441
Query: 493 QAR--------LEEQQRL--AHLEDKLRLLAQAR----DEAQGACLQQKQVVAEAQTRVS 538
+ L+E Q L + L +K LL + R ++A+ L Q +V Q R
Sbjct: 2442 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2501
Query: 539 Q--LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQ--EQNGRLQAELAAQEALR 594
Q Q+E R+RL +E + E V R + ELQ EQ R Q EL A+E R
Sbjct: 2502 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2561
Query: 595 EKAAALERQLKVMASDHREALLDRESENAS 624
L QL+++ HR AL E AS
Sbjct: 2562 -----LREQLQLLEEQHRAALAHSEEVTAS 2586
Score = 76.6 bits (187), Expect = 7e-14
Identities = 118/482 (24%), Positives = 204/482 (42%), Gaps = 64/482 (13%)
Query: 205 LDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLME 264
L + G +VLRA E+ + +Q T E +A L K LR + Q
Sbjct: 1061 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK----LRAQAEAQ----QP 1112
Query: 265 TIDKQREEMAKSSRASAARVGQ-LQEALNERHSIINALKAK----LQMTEAALALSEQKA 319
T D R+E+ A VG+ LQ+ ER + + + L+ +A LA ++ +
Sbjct: 1113 TFDALRDELR-----GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1167
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKL----LRDLSAANEKNLLLQNQ 375
++L +L QL + A L Q+A R+ ++ L D A E+ Q
Sbjct: 1168 RELEQL-----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1222
Query: 376 VDELERKFRCQQE-QLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434
++E+ER +E Q F + EL++ +A+ + + SES+
Sbjct: 1223 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1282
Query: 435 KEVEHMTRHLE-------------ESEKAMQERVQRLEAARLSLEEELSRVKAAALSERG 481
+ V+ T + E E+ + M+E + E R E L+ V+AA +R
Sbjct: 1283 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR- 1341
Query: 482 QAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+L +A +QA+ + ++ L+ +++ R+EA QQK+ + E ++ Q
Sbjct: 1342 ----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1397
Query: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQE-QNGRLQAELAAQEALREKAAAL 600
+ R E + L+ +E + V R+++E E Q G + EL A A E+A A
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEI-RVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1456
Query: 601 ERQLKVMASDHREALLDR---------------ESENASLREKLR-LREAEIARIRDEEA 644
+RQ + A R + D ++E + REK R L+ E R++ EEA
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516
Query: 645 QR 646
+R
Sbjct: 1517 ER 1518
Score = 72.0 bits (175), Expect = 2e-12
Identities = 107/446 (23%), Positives = 196/446 (43%), Gaps = 68/446 (15%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
D + +Q +Q T + + R +S E + L+ ++ M + EE A
Sbjct: 2317 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDA 2371
Query: 275 KSSRASAARVGQ----LQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE 330
+ R A +G+ + A E+ +++ L+ + Q S+ A+ L E +A E
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ-------SDHDAERLREAIAELE 2424
Query: 331 QEQLSLSQRQAKELKLEQQE-AAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQ 389
+E+ L Q++AK L+L+ +E ++ +LL++ A + L ++ + + ER ++ +
Sbjct: 2425 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2483
Query: 390 LFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEK 449
L Q Q+ + + +L+ + +++++ E++R S+E E EE +
Sbjct: 2484 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME--------EARRRQHEAEEGVR 2535
Query: 450 AMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQR--LAHLED 507
QE +Q+LE R EE L+E Q E ++ LEEQ R LAH E+
Sbjct: 2536 RKQEELQQLEQQRRQQEE--------LLAEENQRLREQLQL-----LEEQHRAALAHSEE 2582
Query: 508 -------KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSL 560
+ L RD G AEA+ S GL+ + +RL+E LS
Sbjct: 2583 VTASQVAATKTLPNGRDALDGP-------AAEAEPEHSFDGLRRKVSAQRLQE-AGILSA 2634
Query: 561 KDQERVA-------EVSR---VRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASD 610
++ +R+A E++R VR LQ ++ L A AAL+RQL ++
Sbjct: 2635 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL--LSPG 2692
Query: 611 HREALLDRESENASLREKLRLREAEI 636
LL+ ++ + L + +R R +
Sbjct: 2693 TALILLEAQAASGFLLDPVRNRRLTV 2718
Score = 34.7 bits (78), Expect = 0.29
Identities = 72/334 (21%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 285 GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKEL 344
G+L A+ ER + + +L+ + + + +A E L A+ + Q+
Sbjct: 339 GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD------ALLQSDVR 392
Query: 345 KLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQL----FQTRQEMTSM 400
L + +R ++ RDL A+ LL N V L+ Q EQ+ ++ + + ++
Sbjct: 393 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 452
Query: 401 SAELKMR-----AIQAEE--RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE 453
E +R A A + ++ ++ + R LEDS R+L++ ++E
Sbjct: 453 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDS----------TLRYLQDLLAWVEE 502
Query: 454 RVQRLEAARLSLEEELSRVKAAALSERG--QAEEELIKAKSQARLEEQQRLAHLEDKLRL 511
R++ A + +L V+A S RG Q+ EE +AR +E Q L R
Sbjct: 503 NQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ----LSPATR- 555
Query: 512 LAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSR 571
RD LQ +++ ++ R+ L E L + +EL +++ EV
Sbjct: 556 -GAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAAATKELMWLNEKEEEEVG- 609
Query: 572 VRVELQEQNGRLQAELAAQEALREKAAALERQLK 605
+ ++N + A+ + AL + E+++K
Sbjct: 610 --FDWSDRNTNMTAKKESYSALMRELELKEKKIK 641
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 100 bits (248), Expect = 6e-21
Identities = 124/467 (26%), Positives = 213/467 (45%), Gaps = 53/467 (11%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQH---LREEKSKQFLDLMETIDKQRE 271
D LR+ EQA + + E + R + VQ EE ++Q +E +++ +
Sbjct: 2094 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK- 2152
Query: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
AK A R QE+ + A + +LQ E A A + Q+ + EL T +Q
Sbjct: 2153 --AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQ 2208
Query: 332 EQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF 391
EQ L Q + + + E+++ + AA + QV+E ER + +EQ
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-----RQVEEAERLKQSAEEQA- 2262
Query: 392 QTRQEMTSMSAELKMRAIQ-AEERLDMEKRRCRQ-SLEDSESLRIKEVEHMT----RHLE 445
Q R + + + +L+ A Q A R E+ RQ D+E + K+ T +E
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322
Query: 446 ESEKAMQERVQRLEAARLSLEEELSRVKAAALS---ERGQAEEELIK--------AKSQA 494
+ ++ +++ + + L+EEL R+KA A +R Q EEEL +K +A
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2382
Query: 495 RLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEE- 553
R+E + R L DK ++EA+ + KQV EA R+S + LR+ EE
Sbjct: 2383 RIEAENRALILRDKDNTQRFLQEEAE----KMKQVAEEA-ARLSVAAQEAARLRQLAEED 2437
Query: 554 ------LQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLK 605
L +++ + + V E +R++ E + + Q ELA ++A L+E + +QL
Sbjct: 2438 LAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQLA 2495
Query: 606 VMASDHR---EALLDRESENASLREKLRLREAEIARIR---DEEAQR 646
+ EA R+ E ++ E+L+LR AE++R + +E+AQR
Sbjct: 2496 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542
Score = 96.7 bits (239), Expect = 6e-20
Identities = 111/442 (25%), Positives = 196/442 (44%), Gaps = 66/442 (14%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
++A +A Q L +E + + + ++ E+++Q +ET + E +S
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717
Query: 277 SRAS-AARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
RAS A + QL+ +L E H + L+ + + A +E+ ++ A E E+
Sbjct: 1718 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-----AERELERWQ 1772
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
L +A L+L+ +E A+++S L+ A + Q +E ER+ R
Sbjct: 1773 LKANEALRLRLQAEEVAQQKS-----LAQAE-----AEKQKEEAEREAR----------- 1811
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERV 455
+ + +A++ E + E + RQ E + R+ + + R E+E+ Q+
Sbjct: 1812 ----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-- 1865
Query: 456 QRLEAARLSLEEELSRVK---AAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL 512
R LEEEL+R++ AAA +R + E EL K + A +E L
Sbjct: 1866 ------RQLLEEELARLQREAAAATQKRQELEAELAKVR-----------AEMEVLLASK 1908
Query: 513 AQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV---AEV 569
A+A +E++ + KQ + R +L + LR EE +++ L +++ AE
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968
Query: 570 SRVRVELQEQNG---RLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLR 626
RV E G RL+ E A+ AL+EK A ER L+ +A D EA R E + +
Sbjct: 1969 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENER-LRRLAED--EAFQRRRLEEQAAQ 2023
Query: 627 EKLRLRE--AEIARIRDEEAQR 646
K + E A++ + D E +R
Sbjct: 2024 HKADIEERLAQLRKASDSELER 2045
Score = 90.5 bits (223), Expect = 5e-18
Identities = 112/488 (22%), Positives = 220/488 (45%), Gaps = 52/488 (10%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQA---RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEM 273
L A+ +A + +E +A R L+++ R +Q I+++ ++
Sbjct: 1976 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 2035
Query: 274 AKSSRASAARV-GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE-- 330
K+S + R G +++ L +R + + A E A A + +LG + + AE
Sbjct: 2036 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 2095
Query: 331 ---QEQLSLSQRQAKELKLEQQEAA-ERESKLLRDLSAANEKNLLLQNQVDELER-KFRC 385
+EQ L + ++L E++ E E ++ + L+A E + ++E+ER K +
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155
Query: 386 QQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLE 445
++ + + R E S + +L++ A++RL E++ +++ E + + + L+
Sbjct: 2156 EEARRLRERAEQES-ARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTLQ 2207
Query: 446 ESEKAMQERVQRLEAARLSLEE-ELSRVKA---AALSERGQAEEELIKA----KSQARLE 497
+ + + + EAAR + EE E +RV+A AA S R E E +K ++QAR +
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267
Query: 498 EQQRLAHLEDKLRLLAQARDEAQGACLQQKQVV----------AEAQTR-VSQLGLQVEG 546
Q L + A R +A+ A L+QKQ AE R +Q+ ++
Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2327
Query: 547 LRRRLEELQQELSLKDQE------RVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL 600
LR +LEE + +L D+E E +R R +++E+ ++ ++ L+ + A
Sbjct: 2328 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2387
Query: 601 ERQLKVMASDHREALLDRESEN----ASLREKLRLREAEIARIR----DEEAQRASFLQN 652
R L + D+ + L E+E A +L + E AR+R ++ AQ+ + +
Sbjct: 2388 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2447
Query: 653 AVLAYVQA 660
+ +QA
Sbjct: 2448 MLKEKMQA 2455
Score = 85.5 bits (210), Expect = 1e-16
Identities = 131/534 (24%), Positives = 235/534 (44%), Gaps = 102/534 (19%)
Query: 223 AMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASA- 281
A H+Q + +E + + +EV REE + +I ++ +++ +SS A
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1571
Query: 282 ARVGQLQEALNERHSI---INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQ 338
A+ Q + A R I I ++ +L+ TE +E + Q L AE ++ +Q
Sbjct: 1572 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-AQ 1630
Query: 339 RQAKELKLEQQEAAERE--------SKLLRDLSAANEKNLLLQN------QVDELERKFR 384
+A+ L+ + Q+ ++R+ S++ + AA EK LQ Q +E ER+ R
Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1690
Query: 385 CQQEQLFQTRQ--------------EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430
Q ++ + RQ E+ S A + Q E L E Q E++E
Sbjct: 1691 --QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1748
Query: 431 SLRIKEVEHMTRHLEESEKAMQE-RVQRLEAARLSLE-EELSRVKAAALSE--------- 479
R ++ R EE+E+ ++ +++ EA RL L+ EE+++ K+ A +E
Sbjct: 1749 R-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807
Query: 480 -----RGQAEEELIKAK-----------------SQARLEEQQRLAHL-------EDKLR 510
RG+AEE+ ++ + +Q RL +Q L L E + +
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867
Query: 511 LLAQ--ARDEAQGACLQQKQVVAEAQTRVSQLGLQV-EGLRRRLEELQQELSLKDQERV- 566
LL + AR + + A QK+ EA+ + ++V + R EE + S K ++R+
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1927
Query: 567 AEVSRVRVELQEQNGRLQA---------ELAAQEALREKAAALERQLKV----------M 607
AE R R EL E+ RL+A +LA ++A R++A A ER L +
Sbjct: 1928 AEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKLAAIGEATRL 1985
Query: 608 ASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQAS 661
++ AL ++E+EN LR + R+ ++ AQ + ++ + +AS
Sbjct: 1986 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 2039
Score = 81.6 bits (200), Expect = 2e-15
Identities = 108/450 (24%), Positives = 199/450 (44%), Gaps = 65/450 (14%)
Query: 232 TTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
T Q+ Q + + +Q + K LD E + + + E +++R ++V + ++
Sbjct: 2314 TLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAAR-QRSQVEEELFSV 2370
Query: 292 NERHSIINALKAKLQMTEAALALSEQK-----AQDLGELLATAEQEQLSLS---QRQAKE 343
+ ++ LKA+++ AL L ++ Q+ E + +E LS Q A+
Sbjct: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430
Query: 344 LKLEQQEAAERES---KLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+L +++ A++ + K+L++ A ++ L+ + + L+++ QEQ + +++ M
Sbjct: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490
Query: 401 SAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI--------------------KEVEHM 440
+ +L + L+ E++R + ++E L++ K+ E +
Sbjct: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2550
Query: 441 TRHLEESEKAMQER---VQRLEAARLSLEEELSRVKAAAL-----SERGQAEEELIKAKS 492
L +E A QE+ VQ LE R + + R++ A E+ Q E +L++ KS
Sbjct: 2551 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2610
Query: 493 QAR--------LEEQQRL--AHLEDKLRLLAQAR----DEAQGACLQQKQVVAEAQTRVS 538
+ L+E Q L + L +K LL + R ++A+ L Q +V Q R
Sbjct: 2611 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2670
Query: 539 Q--LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQ--EQNGRLQAELAAQEALR 594
Q Q+E R+RL +E + E V R + ELQ EQ R Q EL A+E R
Sbjct: 2671 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730
Query: 595 EKAAALERQLKVMASDHREALLDRESENAS 624
L QL+++ HR AL E AS
Sbjct: 2731 -----LREQLQLLEEQHRAALAHSEEVTAS 2755
Score = 76.6 bits (187), Expect = 7e-14
Identities = 118/482 (24%), Positives = 204/482 (42%), Gaps = 64/482 (13%)
Query: 205 LDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLME 264
L + G +VLRA E+ + +Q T E +A L K LR + Q
Sbjct: 1230 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK----LRAQAEAQ----QP 1281
Query: 265 TIDKQREEMAKSSRASAARVGQ-LQEALNERHSIINALKAK----LQMTEAALALSEQKA 319
T D R+E+ A VG+ LQ+ ER + + + L+ +A LA ++ +
Sbjct: 1282 TFDALRDELR-----GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1336
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKL----LRDLSAANEKNLLLQNQ 375
++L +L QL + A L Q+A R+ ++ L D A E+ Q
Sbjct: 1337 RELEQL-----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1391
Query: 376 VDELERKFRCQQE-QLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434
++E+ER +E Q F + EL++ +A+ + + SES+
Sbjct: 1392 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1451
Query: 435 KEVEHMTRHLE-------------ESEKAMQERVQRLEAARLSLEEELSRVKAAALSERG 481
+ V+ T + E E+ + M+E + E R E L+ V+AA +R
Sbjct: 1452 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR- 1510
Query: 482 QAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+L +A +QA+ + ++ L+ +++ R+EA QQK+ + E ++ Q
Sbjct: 1511 ----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1566
Query: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQE-QNGRLQAELAAQEALREKAAAL 600
+ R E + L+ +E + V R+++E E Q G + EL A A E+A A
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEI-RVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1625
Query: 601 ERQLKVMASDHREALLDR---------------ESENASLREKLR-LREAEIARIRDEEA 644
+RQ + A R + D ++E + REK R L+ E R++ EEA
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685
Query: 645 QR 646
+R
Sbjct: 1686 ER 1687
Score = 72.0 bits (175), Expect = 2e-12
Identities = 107/446 (23%), Positives = 196/446 (43%), Gaps = 68/446 (15%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
D + +Q +Q T + + R +S E + L+ ++ M + EE A
Sbjct: 2486 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDA 2540
Query: 275 KSSRASAARVGQ----LQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE 330
+ R A +G+ + A E+ +++ L+ + Q S+ A+ L E +A E
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ-------SDHDAERLREAIAELE 2593
Query: 331 QEQLSLSQRQAKELKLEQQE-AAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQ 389
+E+ L Q++AK L+L+ +E ++ +LL++ A + L ++ + + ER ++ +
Sbjct: 2594 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2652
Query: 390 LFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEK 449
L Q Q+ + + +L+ + +++++ E++R S+E E EE +
Sbjct: 2653 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME--------EARRRQHEAEEGVR 2704
Query: 450 AMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQR--LAHLED 507
QE +Q+LE R EE L+E Q E ++ LEEQ R LAH E+
Sbjct: 2705 RKQEELQQLEQQRRQQEE--------LLAEENQRLREQLQL-----LEEQHRAALAHSEE 2751
Query: 508 -------KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSL 560
+ L RD G AEA+ S GL+ + +RL+E LS
Sbjct: 2752 VTASQVAATKTLPNGRDALDGP-------AAEAEPEHSFDGLRRKVSAQRLQE-AGILSA 2803
Query: 561 KDQERVA-------EVSR---VRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASD 610
++ +R+A E++R VR LQ ++ L A AAL+RQL ++
Sbjct: 2804 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL--LSPG 2861
Query: 611 HREALLDRESENASLREKLRLREAEI 636
LL+ ++ + L + +R R +
Sbjct: 2862 TALILLEAQAASGFLLDPVRNRRLTV 2887
Score = 34.7 bits (78), Expect = 0.29
Identities = 72/334 (21%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 285 GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKEL 344
G+L A+ ER + + +L+ + + + +A E L A+ + Q+
Sbjct: 508 GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD------ALLQSDVR 561
Query: 345 KLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQL----FQTRQEMTSM 400
L + +R ++ RDL A+ LL N V L+ Q EQ+ ++ + + ++
Sbjct: 562 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 621
Query: 401 SAELKMR-----AIQAEE--RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE 453
E +R A A + ++ ++ + R LEDS R+L++ ++E
Sbjct: 622 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDS----------TLRYLQDLLAWVEE 671
Query: 454 RVQRLEAARLSLEEELSRVKAAALSERG--QAEEELIKAKSQARLEEQQRLAHLEDKLRL 511
R++ A + +L V+A S RG Q+ EE +AR +E Q L R
Sbjct: 672 NQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ----LSPATR- 724
Query: 512 LAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSR 571
RD LQ +++ ++ R+ L E L + +EL +++ EV
Sbjct: 725 -GAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAAATKELMWLNEKEEEEVG- 778
Query: 572 VRVELQEQNGRLQAELAAQEALREKAAALERQLK 605
+ ++N + A+ + AL + E+++K
Sbjct: 779 --FDWSDRNTNMTAKKESYSALMRELELKEKKIK 810
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 100 bits (248), Expect = 6e-21
Identities = 124/467 (26%), Positives = 213/467 (45%), Gaps = 53/467 (11%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQH---LREEKSKQFLDLMETIDKQRE 271
D LR+ EQA + + E + R + VQ EE ++Q +E +++ +
Sbjct: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK- 1993
Query: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
AK A R QE+ + A + +LQ E A A + Q+ + EL T +Q
Sbjct: 1994 --AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQ 2049
Query: 332 EQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF 391
EQ L Q + + + E+++ + AA + QV+E ER + +EQ
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-----RQVEEAERLKQSAEEQA- 2103
Query: 392 QTRQEMTSMSAELKMRAIQ-AEERLDMEKRRCRQ-SLEDSESLRIKEVEHMT----RHLE 445
Q R + + + +L+ A Q A R E+ RQ D+E + K+ T +E
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163
Query: 446 ESEKAMQERVQRLEAARLSLEEELSRVKAAALS---ERGQAEEELIK--------AKSQA 494
+ ++ +++ + + L+EEL R+KA A +R Q EEEL +K +A
Sbjct: 2164 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2223
Query: 495 RLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEE- 553
R+E + R L DK ++EA+ + KQV EA R+S + LR+ EE
Sbjct: 2224 RIEAENRALILRDKDNTQRFLQEEAE----KMKQVAEEA-ARLSVAAQEAARLRQLAEED 2278
Query: 554 ------LQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLK 605
L +++ + + V E +R++ E + + Q ELA ++A L+E + +QL
Sbjct: 2279 LAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQLA 2336
Query: 606 VMASDHR---EALLDRESENASLREKLRLREAEIARIR---DEEAQR 646
+ EA R+ E ++ E+L+LR AE++R + +E+AQR
Sbjct: 2337 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383
Score = 96.7 bits (239), Expect = 6e-20
Identities = 111/442 (25%), Positives = 196/442 (44%), Gaps = 66/442 (14%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
++A +A Q L +E + + + ++ E+++Q +ET + E +S
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558
Query: 277 SRAS-AARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
RAS A + QL+ +L E H + L+ + + A +E+ ++ A E E+
Sbjct: 1559 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-----AERELERWQ 1613
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
L +A L+L+ +E A+++S L+ A + Q +E ER+ R
Sbjct: 1614 LKANEALRLRLQAEEVAQQKS-----LAQAE-----AEKQKEEAEREAR----------- 1652
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERV 455
+ + +A++ E + E + RQ E + R+ + + R E+E+ Q+
Sbjct: 1653 ----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-- 1706
Query: 456 QRLEAARLSLEEELSRVK---AAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL 512
R LEEEL+R++ AAA +R + E EL K + A +E L
Sbjct: 1707 ------RQLLEEELARLQREAAAATQKRQELEAELAKVR-----------AEMEVLLASK 1749
Query: 513 AQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV---AEV 569
A+A +E++ + KQ + R +L + LR EE +++ L +++ AE
Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
Query: 570 SRVRVELQEQNG---RLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLR 626
RV E G RL+ E A+ AL+EK A ER L+ +A D EA R E + +
Sbjct: 1810 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENER-LRRLAED--EAFQRRRLEEQAAQ 1864
Query: 627 EKLRLRE--AEIARIRDEEAQR 646
K + E A++ + D E +R
Sbjct: 1865 HKADIEERLAQLRKASDSELER 1886
Score = 90.5 bits (223), Expect = 5e-18
Identities = 112/488 (22%), Positives = 220/488 (45%), Gaps = 52/488 (10%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQA---RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEM 273
L A+ +A + +E +A R L+++ R +Q I+++ ++
Sbjct: 1817 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1876
Query: 274 AKSSRASAARV-GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE-- 330
K+S + R G +++ L +R + + A E A A + +LG + + AE
Sbjct: 1877 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1936
Query: 331 ---QEQLSLSQRQAKELKLEQQEAA-ERESKLLRDLSAANEKNLLLQNQVDELER-KFRC 385
+EQ L + ++L E++ E E ++ + L+A E + ++E+ER K +
Sbjct: 1937 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996
Query: 386 QQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLE 445
++ + + R E S + +L++ A++RL E++ +++ E + + + L+
Sbjct: 1997 EEARRLRERAEQES-ARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTLQ 2048
Query: 446 ESEKAMQERVQRLEAARLSLEE-ELSRVKA---AALSERGQAEEELIKA----KSQARLE 497
+ + + + EAAR + EE E +RV+A AA S R E E +K ++QAR +
Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108
Query: 498 EQQRLAHLEDKLRLLAQARDEAQGACLQQKQVV----------AEAQTR-VSQLGLQVEG 546
Q L + A R +A+ A L+QKQ AE R +Q+ ++
Sbjct: 2109 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2168
Query: 547 LRRRLEELQQELSLKDQE------RVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL 600
LR +LEE + +L D+E E +R R +++E+ ++ ++ L+ + A
Sbjct: 2169 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2228
Query: 601 ERQLKVMASDHREALLDRESEN----ASLREKLRLREAEIARIR----DEEAQRASFLQN 652
R L + D+ + L E+E A +L + E AR+R ++ AQ+ + +
Sbjct: 2229 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2288
Query: 653 AVLAYVQA 660
+ +QA
Sbjct: 2289 MLKEKMQA 2296
Score = 85.5 bits (210), Expect = 1e-16
Identities = 131/534 (24%), Positives = 235/534 (44%), Gaps = 102/534 (19%)
Query: 223 AMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASA- 281
A H+Q + +E + + +EV REE + +I ++ +++ +SS A
Sbjct: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1412
Query: 282 ARVGQLQEALNERHSI---INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQ 338
A+ Q + A R I I ++ +L+ TE +E + Q L AE ++ +Q
Sbjct: 1413 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-AQ 1471
Query: 339 RQAKELKLEQQEAAERE--------SKLLRDLSAANEKNLLLQN------QVDELERKFR 384
+A+ L+ + Q+ ++R+ S++ + AA EK LQ Q +E ER+ R
Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1531
Query: 385 CQQEQLFQTRQ--------------EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430
Q ++ + RQ E+ S A + Q E L E Q E++E
Sbjct: 1532 --QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1589
Query: 431 SLRIKEVEHMTRHLEESEKAMQE-RVQRLEAARLSLE-EELSRVKAAALSE--------- 479
R ++ R EE+E+ ++ +++ EA RL L+ EE+++ K+ A +E
Sbjct: 1590 R-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648
Query: 480 -----RGQAEEELIKAK-----------------SQARLEEQQRLAHL-------EDKLR 510
RG+AEE+ ++ + +Q RL +Q L L E + +
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708
Query: 511 LLAQ--ARDEAQGACLQQKQVVAEAQTRVSQLGLQV-EGLRRRLEELQQELSLKDQERV- 566
LL + AR + + A QK+ EA+ + ++V + R EE + S K ++R+
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1768
Query: 567 AEVSRVRVELQEQNGRLQA---------ELAAQEALREKAAALERQLKV----------M 607
AE R R EL E+ RL+A +LA ++A R++A A ER L +
Sbjct: 1769 AEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKLAAIGEATRL 1826
Query: 608 ASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQAS 661
++ AL ++E+EN LR + R+ ++ AQ + ++ + +AS
Sbjct: 1827 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1880
Score = 81.6 bits (200), Expect = 2e-15
Identities = 108/450 (24%), Positives = 199/450 (44%), Gaps = 65/450 (14%)
Query: 232 TTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
T Q+ Q + + +Q + K LD E + + + E +++R ++V + ++
Sbjct: 2155 TLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAAR-QRSQVEEELFSV 2211
Query: 292 NERHSIINALKAKLQMTEAALALSEQK-----AQDLGELLATAEQEQLSLS---QRQAKE 343
+ ++ LKA+++ AL L ++ Q+ E + +E LS Q A+
Sbjct: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271
Query: 344 LKLEQQEAAERES---KLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+L +++ A++ + K+L++ A ++ L+ + + L+++ QEQ + +++ M
Sbjct: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331
Query: 401 SAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI--------------------KEVEHM 440
+ +L + L+ E++R + ++E L++ K+ E +
Sbjct: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2391
Query: 441 TRHLEESEKAMQER---VQRLEAARLSLEEELSRVKAAAL-----SERGQAEEELIKAKS 492
L +E A QE+ VQ LE R + + R++ A E+ Q E +L++ KS
Sbjct: 2392 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2451
Query: 493 QAR--------LEEQQRL--AHLEDKLRLLAQAR----DEAQGACLQQKQVVAEAQTRVS 538
+ L+E Q L + L +K LL + R ++A+ L Q +V Q R
Sbjct: 2452 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2511
Query: 539 Q--LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQ--EQNGRLQAELAAQEALR 594
Q Q+E R+RL +E + E V R + ELQ EQ R Q EL A+E R
Sbjct: 2512 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571
Query: 595 EKAAALERQLKVMASDHREALLDRESENAS 624
L QL+++ HR AL E AS
Sbjct: 2572 -----LREQLQLLEEQHRAALAHSEEVTAS 2596
Score = 76.6 bits (187), Expect = 7e-14
Identities = 118/482 (24%), Positives = 204/482 (42%), Gaps = 64/482 (13%)
Query: 205 LDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLME 264
L + G +VLRA E+ + +Q T E +A L K LR + Q
Sbjct: 1071 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK----LRAQAEAQ----QP 1122
Query: 265 TIDKQREEMAKSSRASAARVGQ-LQEALNERHSIINALKAK----LQMTEAALALSEQKA 319
T D R+E+ A VG+ LQ+ ER + + + L+ +A LA ++ +
Sbjct: 1123 TFDALRDELR-----GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1177
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKL----LRDLSAANEKNLLLQNQ 375
++L +L QL + A L Q+A R+ ++ L D A E+ Q
Sbjct: 1178 RELEQL-----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1232
Query: 376 VDELERKFRCQQE-QLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434
++E+ER +E Q F + EL++ +A+ + + SES+
Sbjct: 1233 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1292
Query: 435 KEVEHMTRHLE-------------ESEKAMQERVQRLEAARLSLEEELSRVKAAALSERG 481
+ V+ T + E E+ + M+E + E R E L+ V+AA +R
Sbjct: 1293 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR- 1351
Query: 482 QAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+L +A +QA+ + ++ L+ +++ R+EA QQK+ + E ++ Q
Sbjct: 1352 ----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1407
Query: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQE-QNGRLQAELAAQEALREKAAAL 600
+ R E + L+ +E + V R+++E E Q G + EL A A E+A A
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEI-RVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1466
Query: 601 ERQLKVMASDHREALLDR---------------ESENASLREKLR-LREAEIARIRDEEA 644
+RQ + A R + D ++E + REK R L+ E R++ EEA
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526
Query: 645 QR 646
+R
Sbjct: 1527 ER 1528
Score = 72.0 bits (175), Expect = 2e-12
Identities = 107/446 (23%), Positives = 196/446 (43%), Gaps = 68/446 (15%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
D + +Q +Q T + + R +S E + L+ ++ M + EE A
Sbjct: 2327 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDA 2381
Query: 275 KSSRASAARVGQ----LQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE 330
+ R A +G+ + A E+ +++ L+ + Q S+ A+ L E +A E
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ-------SDHDAERLREAIAELE 2434
Query: 331 QEQLSLSQRQAKELKLEQQE-AAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQ 389
+E+ L Q++AK L+L+ +E ++ +LL++ A + L ++ + + ER ++ +
Sbjct: 2435 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2493
Query: 390 LFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEK 449
L Q Q+ + + +L+ + +++++ E++R S+E E EE +
Sbjct: 2494 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME--------EARRRQHEAEEGVR 2545
Query: 450 AMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQR--LAHLED 507
QE +Q+LE R EE L+E Q E ++ LEEQ R LAH E+
Sbjct: 2546 RKQEELQQLEQQRRQQEE--------LLAEENQRLREQLQL-----LEEQHRAALAHSEE 2592
Query: 508 -------KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSL 560
+ L RD G AEA+ S GL+ + +RL+E LS
Sbjct: 2593 VTASQVAATKTLPNGRDALDGP-------AAEAEPEHSFDGLRRKVSAQRLQE-AGILSA 2644
Query: 561 KDQERVA-------EVSR---VRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASD 610
++ +R+A E++R VR LQ ++ L A AAL+RQL ++
Sbjct: 2645 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL--LSPG 2702
Query: 611 HREALLDRESENASLREKLRLREAEI 636
LL+ ++ + L + +R R +
Sbjct: 2703 TALILLEAQAASGFLLDPVRNRRLTV 2728
Score = 34.7 bits (78), Expect = 0.29
Identities = 72/334 (21%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 285 GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKEL 344
G+L A+ ER + + +L+ + + + +A E L A+ + Q+
Sbjct: 349 GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD------ALLQSDVR 402
Query: 345 KLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQL----FQTRQEMTSM 400
L + +R ++ RDL A+ LL N V L+ Q EQ+ ++ + + ++
Sbjct: 403 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 462
Query: 401 SAELKMR-----AIQAEE--RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE 453
E +R A A + ++ ++ + R LEDS R+L++ ++E
Sbjct: 463 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDS----------TLRYLQDLLAWVEE 512
Query: 454 RVQRLEAARLSLEEELSRVKAAALSERG--QAEEELIKAKSQARLEEQQRLAHLEDKLRL 511
R++ A + +L V+A S RG Q+ EE +AR +E Q L R
Sbjct: 513 NQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ----LSPATR- 565
Query: 512 LAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSR 571
RD LQ +++ ++ R+ L E L + +EL +++ EV
Sbjct: 566 -GAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAAATKELMWLNEKEEEEVG- 619
Query: 572 VRVELQEQNGRLQAELAAQEALREKAAALERQLK 605
+ ++N + A+ + AL + E+++K
Sbjct: 620 --FDWSDRNTNMTAKKESYSALMRELELKEKKIK 651
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 100 bits (248), Expect = 6e-21
Identities = 124/467 (26%), Positives = 213/467 (45%), Gaps = 53/467 (11%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQH---LREEKSKQFLDLMETIDKQRE 271
D LR+ EQA + + E + R + VQ EE ++Q +E +++ +
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK- 2001
Query: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
AK A R QE+ + A + +LQ E A A + Q+ + EL T +Q
Sbjct: 2002 --AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQ 2057
Query: 332 EQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF 391
EQ L Q + + + E+++ + AA + QV+E ER + +EQ
Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-----RQVEEAERLKQSAEEQA- 2111
Query: 392 QTRQEMTSMSAELKMRAIQ-AEERLDMEKRRCRQ-SLEDSESLRIKEVEHMT----RHLE 445
Q R + + + +L+ A Q A R E+ RQ D+E + K+ T +E
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171
Query: 446 ESEKAMQERVQRLEAARLSLEEELSRVKAAALS---ERGQAEEELIK--------AKSQA 494
+ ++ +++ + + L+EEL R+KA A +R Q EEEL +K +A
Sbjct: 2172 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2231
Query: 495 RLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEE- 553
R+E + R L DK ++EA+ + KQV EA R+S + LR+ EE
Sbjct: 2232 RIEAENRALILRDKDNTQRFLQEEAE----KMKQVAEEA-ARLSVAAQEAARLRQLAEED 2286
Query: 554 ------LQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLK 605
L +++ + + V E +R++ E + + Q ELA ++A L+E + +QL
Sbjct: 2287 LAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQLA 2344
Query: 606 VMASDHR---EALLDRESENASLREKLRLREAEIARIR---DEEAQR 646
+ EA R+ E ++ E+L+LR AE++R + +E+AQR
Sbjct: 2345 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2391
Score = 96.7 bits (239), Expect = 6e-20
Identities = 111/442 (25%), Positives = 196/442 (44%), Gaps = 66/442 (14%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
++A +A Q L +E + + + ++ E+++Q +ET + E +S
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566
Query: 277 SRAS-AARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
RAS A + QL+ +L E H + L+ + + A +E+ ++ A E E+
Sbjct: 1567 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-----AERELERWQ 1621
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
L +A L+L+ +E A+++S L+ A + Q +E ER+ R
Sbjct: 1622 LKANEALRLRLQAEEVAQQKS-----LAQAE-----AEKQKEEAEREAR----------- 1660
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERV 455
+ + +A++ E + E + RQ E + R+ + + R E+E+ Q+
Sbjct: 1661 ----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-- 1714
Query: 456 QRLEAARLSLEEELSRVK---AAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL 512
R LEEEL+R++ AAA +R + E EL K + A +E L
Sbjct: 1715 ------RQLLEEELARLQREAAAATQKRQELEAELAKVR-----------AEMEVLLASK 1757
Query: 513 AQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV---AEV 569
A+A +E++ + KQ + R +L + LR EE +++ L +++ AE
Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817
Query: 570 SRVRVELQEQNG---RLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLR 626
RV E G RL+ E A+ AL+EK A ER L+ +A D EA R E + +
Sbjct: 1818 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENER-LRRLAED--EAFQRRRLEEQAAQ 1872
Query: 627 EKLRLRE--AEIARIRDEEAQR 646
K + E A++ + D E +R
Sbjct: 1873 HKADIEERLAQLRKASDSELER 1894
Score = 90.5 bits (223), Expect = 5e-18
Identities = 112/488 (22%), Positives = 220/488 (45%), Gaps = 52/488 (10%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQA---RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEM 273
L A+ +A + +E +A R L+++ R +Q I+++ ++
Sbjct: 1825 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1884
Query: 274 AKSSRASAARV-GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE-- 330
K+S + R G +++ L +R + + A E A A + +LG + + AE
Sbjct: 1885 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1944
Query: 331 ---QEQLSLSQRQAKELKLEQQEAA-ERESKLLRDLSAANEKNLLLQNQVDELER-KFRC 385
+EQ L + ++L E++ E E ++ + L+A E + ++E+ER K +
Sbjct: 1945 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2004
Query: 386 QQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLE 445
++ + + R E S + +L++ A++RL E++ +++ E + + + L+
Sbjct: 2005 EEARRLRERAEQES-ARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTLQ 2056
Query: 446 ESEKAMQERVQRLEAARLSLEE-ELSRVKA---AALSERGQAEEELIKA----KSQARLE 497
+ + + + EAAR + EE E +RV+A AA S R E E +K ++QAR +
Sbjct: 2057 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116
Query: 498 EQQRLAHLEDKLRLLAQARDEAQGACLQQKQVV----------AEAQTR-VSQLGLQVEG 546
Q L + A R +A+ A L+QKQ AE R +Q+ ++
Sbjct: 2117 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2176
Query: 547 LRRRLEELQQELSLKDQE------RVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL 600
LR +LEE + +L D+E E +R R +++E+ ++ ++ L+ + A
Sbjct: 2177 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2236
Query: 601 ERQLKVMASDHREALLDRESEN----ASLREKLRLREAEIARIR----DEEAQRASFLQN 652
R L + D+ + L E+E A +L + E AR+R ++ AQ+ + +
Sbjct: 2237 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2296
Query: 653 AVLAYVQA 660
+ +QA
Sbjct: 2297 MLKEKMQA 2304
Score = 85.5 bits (210), Expect = 1e-16
Identities = 131/534 (24%), Positives = 235/534 (44%), Gaps = 102/534 (19%)
Query: 223 AMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASA- 281
A H+Q + +E + + +EV REE + +I ++ +++ +SS A
Sbjct: 1362 AEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1420
Query: 282 ARVGQLQEALNERHSI---INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQ 338
A+ Q + A R I I ++ +L+ TE +E + Q L AE ++ +Q
Sbjct: 1421 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-AQ 1479
Query: 339 RQAKELKLEQQEAAERE--------SKLLRDLSAANEKNLLLQN------QVDELERKFR 384
+A+ L+ + Q+ ++R+ S++ + AA EK LQ Q +E ER+ R
Sbjct: 1480 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1539
Query: 385 CQQEQLFQTRQ--------------EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430
Q ++ + RQ E+ S A + Q E L E Q E++E
Sbjct: 1540 --QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1597
Query: 431 SLRIKEVEHMTRHLEESEKAMQE-RVQRLEAARLSLE-EELSRVKAAALSE--------- 479
R ++ R EE+E+ ++ +++ EA RL L+ EE+++ K+ A +E
Sbjct: 1598 R-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656
Query: 480 -----RGQAEEELIKAK-----------------SQARLEEQQRLAHL-------EDKLR 510
RG+AEE+ ++ + +Q RL +Q L L E + +
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1716
Query: 511 LLAQ--ARDEAQGACLQQKQVVAEAQTRVSQLGLQV-EGLRRRLEELQQELSLKDQERV- 566
LL + AR + + A QK+ EA+ + ++V + R EE + S K ++R+
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1776
Query: 567 AEVSRVRVELQEQNGRLQA---------ELAAQEALREKAAALERQLKV----------M 607
AE R R EL E+ RL+A +LA ++A R++A A ER L +
Sbjct: 1777 AEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKLAAIGEATRL 1834
Query: 608 ASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQAS 661
++ AL ++E+EN LR + R+ ++ AQ + ++ + +AS
Sbjct: 1835 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1888
Score = 81.6 bits (200), Expect = 2e-15
Identities = 108/450 (24%), Positives = 199/450 (44%), Gaps = 65/450 (14%)
Query: 232 TTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
T Q+ Q + + +Q + K LD E + + + E +++R ++V + ++
Sbjct: 2163 TLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAAR-QRSQVEEELFSV 2219
Query: 292 NERHSIINALKAKLQMTEAALALSEQK-----AQDLGELLATAEQEQLSLS---QRQAKE 343
+ ++ LKA+++ AL L ++ Q+ E + +E LS Q A+
Sbjct: 2220 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2279
Query: 344 LKLEQQEAAERES---KLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+L +++ A++ + K+L++ A ++ L+ + + L+++ QEQ + +++ M
Sbjct: 2280 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2339
Query: 401 SAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI--------------------KEVEHM 440
+ +L + L+ E++R + ++E L++ K+ E +
Sbjct: 2340 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2399
Query: 441 TRHLEESEKAMQER---VQRLEAARLSLEEELSRVKAAAL-----SERGQAEEELIKAKS 492
L +E A QE+ VQ LE R + + R++ A E+ Q E +L++ KS
Sbjct: 2400 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2459
Query: 493 QAR--------LEEQQRL--AHLEDKLRLLAQAR----DEAQGACLQQKQVVAEAQTRVS 538
+ L+E Q L + L +K LL + R ++A+ L Q +V Q R
Sbjct: 2460 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2519
Query: 539 Q--LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQ--EQNGRLQAELAAQEALR 594
Q Q+E R+RL +E + E V R + ELQ EQ R Q EL A+E R
Sbjct: 2520 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2579
Query: 595 EKAAALERQLKVMASDHREALLDRESENAS 624
L QL+++ HR AL E AS
Sbjct: 2580 -----LREQLQLLEEQHRAALAHSEEVTAS 2604
Score = 76.6 bits (187), Expect = 7e-14
Identities = 118/482 (24%), Positives = 204/482 (42%), Gaps = 64/482 (13%)
Query: 205 LDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLME 264
L + G +VLRA E+ + +Q T E +A L K LR + Q
Sbjct: 1079 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK----LRAQAEAQ----QP 1130
Query: 265 TIDKQREEMAKSSRASAARVGQ-LQEALNERHSIINALKAK----LQMTEAALALSEQKA 319
T D R+E+ A VG+ LQ+ ER + + + L+ +A LA ++ +
Sbjct: 1131 TFDALRDELR-----GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1185
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKL----LRDLSAANEKNLLLQNQ 375
++L +L QL + A L Q+A R+ ++ L D A E+ Q
Sbjct: 1186 RELEQL-----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1240
Query: 376 VDELERKFRCQQE-QLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434
++E+ER +E Q F + EL++ +A+ + + SES+
Sbjct: 1241 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1300
Query: 435 KEVEHMTRHLE-------------ESEKAMQERVQRLEAARLSLEEELSRVKAAALSERG 481
+ V+ T + E E+ + M+E + E R E L+ V+AA +R
Sbjct: 1301 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR- 1359
Query: 482 QAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+L +A +QA+ + ++ L+ +++ R+EA QQK+ + E ++ Q
Sbjct: 1360 ----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1415
Query: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQE-QNGRLQAELAAQEALREKAAAL 600
+ R E + L+ +E + V R+++E E Q G + EL A A E+A A
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEI-RVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1474
Query: 601 ERQLKVMASDHREALLDR---------------ESENASLREKLR-LREAEIARIRDEEA 644
+RQ + A R + D ++E + REK R L+ E R++ EEA
Sbjct: 1475 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1534
Query: 645 QR 646
+R
Sbjct: 1535 ER 1536
Score = 72.0 bits (175), Expect = 2e-12
Identities = 107/446 (23%), Positives = 196/446 (43%), Gaps = 68/446 (15%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
D + +Q +Q T + + R +S E + L+ ++ M + EE A
Sbjct: 2335 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDA 2389
Query: 275 KSSRASAARVGQ----LQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE 330
+ R A +G+ + A E+ +++ L+ + Q S+ A+ L E +A E
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ-------SDHDAERLREAIAELE 2442
Query: 331 QEQLSLSQRQAKELKLEQQE-AAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQ 389
+E+ L Q++AK L+L+ +E ++ +LL++ A + L ++ + + ER ++ +
Sbjct: 2443 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2501
Query: 390 LFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEK 449
L Q Q+ + + +L+ + +++++ E++R S+E E EE +
Sbjct: 2502 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME--------EARRRQHEAEEGVR 2553
Query: 450 AMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQR--LAHLED 507
QE +Q+LE R EE L+E Q E ++ LEEQ R LAH E+
Sbjct: 2554 RKQEELQQLEQQRRQQEE--------LLAEENQRLREQLQL-----LEEQHRAALAHSEE 2600
Query: 508 -------KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSL 560
+ L RD G AEA+ S GL+ + +RL+E LS
Sbjct: 2601 VTASQVAATKTLPNGRDALDGP-------AAEAEPEHSFDGLRRKVSAQRLQE-AGILSA 2652
Query: 561 KDQERVA-------EVSR---VRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASD 610
++ +R+A E++R VR LQ ++ L A AAL+RQL ++
Sbjct: 2653 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL--LSPG 2710
Query: 611 HREALLDRESENASLREKLRLREAEI 636
LL+ ++ + L + +R R +
Sbjct: 2711 TALILLEAQAASGFLLDPVRNRRLTV 2736
Score = 34.7 bits (78), Expect = 0.29
Identities = 72/334 (21%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 285 GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKEL 344
G+L A+ ER + + +L+ + + + +A E L A+ + Q+
Sbjct: 357 GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD------ALLQSDVR 410
Query: 345 KLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQL----FQTRQEMTSM 400
L + +R ++ RDL A+ LL N V L+ Q EQ+ ++ + + ++
Sbjct: 411 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 470
Query: 401 SAELKMR-----AIQAEE--RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE 453
E +R A A + ++ ++ + R LEDS R+L++ ++E
Sbjct: 471 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDS----------TLRYLQDLLAWVEE 520
Query: 454 RVQRLEAARLSLEEELSRVKAAALSERG--QAEEELIKAKSQARLEEQQRLAHLEDKLRL 511
R++ A + +L V+A S RG Q+ EE +AR +E Q L R
Sbjct: 521 NQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ----LSPATR- 573
Query: 512 LAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSR 571
RD LQ +++ ++ R+ L E L + +EL +++ EV
Sbjct: 574 -GAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAAATKELMWLNEKEEEEVG- 627
Query: 572 VRVELQEQNGRLQAELAAQEALREKAAALERQLK 605
+ ++N + A+ + AL + E+++K
Sbjct: 628 --FDWSDRNTNMTAKKESYSALMRELELKEKKIK 659
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 100 bits (248), Expect = 6e-21
Identities = 124/467 (26%), Positives = 213/467 (45%), Gaps = 53/467 (11%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQH---LREEKSKQFLDLMETIDKQRE 271
D LR+ EQA + + E + R + VQ EE ++Q +E +++ +
Sbjct: 1984 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLK- 2042
Query: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
AK A R QE+ + A + +LQ E A A + Q+ + EL T +Q
Sbjct: 2043 --AKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQ--ELQQTLQQ 2098
Query: 332 EQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF 391
EQ L Q + + + E+++ + AA + QV+E ER + +EQ
Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR-----RQVEEAERLKQSAEEQA- 2152
Query: 392 QTRQEMTSMSAELKMRAIQ-AEERLDMEKRRCRQ-SLEDSESLRIKEVEHMT----RHLE 445
Q R + + + +L+ A Q A R E+ RQ D+E + K+ T +E
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212
Query: 446 ESEKAMQERVQRLEAARLSLEEELSRVKAAALS---ERGQAEEELIK--------AKSQA 494
+ ++ +++ + + L+EEL R+KA A +R Q EEEL +K +A
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272
Query: 495 RLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEE- 553
R+E + R L DK ++EA+ + KQV EA R+S + LR+ EE
Sbjct: 2273 RIEAENRALILRDKDNTQRFLQEEAE----KMKQVAEEA-ARLSVAAQEAARLRQLAEED 2327
Query: 554 ------LQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEA--LREKAAALERQLK 605
L +++ + + V E +R++ E + + Q ELA ++A L+E + +QL
Sbjct: 2328 LAQQRALAEKMLKEKMQAVQEATRLKAEAELL--QQQKELAQEQARRLQEDKEQMAQQLA 2385
Query: 606 VMASDHR---EALLDRESENASLREKLRLREAEIARIR---DEEAQR 646
+ EA R+ E ++ E+L+LR AE++R + +E+AQR
Sbjct: 2386 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432
Score = 96.7 bits (239), Expect = 6e-20
Identities = 111/442 (25%), Positives = 196/442 (44%), Gaps = 66/442 (14%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
++A +A Q L +E + + + ++ E+++Q +ET + E +S
Sbjct: 1548 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607
Query: 277 SRAS-AARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
RAS A + QL+ +L E H + L+ + + A +E+ ++ A E E+
Sbjct: 1608 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE-----AERELERWQ 1662
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
L +A L+L+ +E A+++S L+ A + Q +E ER+ R
Sbjct: 1663 LKANEALRLRLQAEEVAQQKS-----LAQAE-----AEKQKEEAEREAR----------- 1701
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERV 455
+ + +A++ E + E + RQ E + R+ + + R E+E+ Q+
Sbjct: 1702 ----RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ-- 1755
Query: 456 QRLEAARLSLEEELSRVK---AAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL 512
R LEEEL+R++ AAA +R + E EL K + A +E L
Sbjct: 1756 ------RQLLEEELARLQREAAAATQKRQELEAELAKVR-----------AEMEVLLASK 1798
Query: 513 AQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV---AEV 569
A+A +E++ + KQ + R +L + LR EE +++ L +++ AE
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
Query: 570 SRVRVELQEQNG---RLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLR 626
RV E G RL+ E A+ AL+EK A ER L+ +A D EA R E + +
Sbjct: 1859 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENER-LRRLAED--EAFQRRRLEEQAAQ 1913
Query: 627 EKLRLRE--AEIARIRDEEAQR 646
K + E A++ + D E +R
Sbjct: 1914 HKADIEERLAQLRKASDSELER 1935
Score = 90.5 bits (223), Expect = 5e-18
Identities = 112/488 (22%), Positives = 220/488 (45%), Gaps = 52/488 (10%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQA---RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEM 273
L A+ +A + +E +A R L+++ R +Q I+++ ++
Sbjct: 1866 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1925
Query: 274 AKSSRASAARV-GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE-- 330
K+S + R G +++ L +R + + A E A A + +LG + + AE
Sbjct: 1926 RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDT 1985
Query: 331 ---QEQLSLSQRQAKELKLEQQEAA-ERESKLLRDLSAANEKNLLLQNQVDELER-KFRC 385
+EQ L + ++L E++ E E ++ + L+A E + ++E+ER K +
Sbjct: 1986 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2045
Query: 386 QQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLE 445
++ + + R E S + +L++ A++RL E++ +++ E + + + L+
Sbjct: 2046 EEARRLRERAEQES-ARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-------QELQQTLQ 2097
Query: 446 ESEKAMQERVQRLEAARLSLEE-ELSRVKA---AALSERGQAEEELIKA----KSQARLE 497
+ + + + EAAR + EE E +RV+A AA S R E E +K ++QAR +
Sbjct: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157
Query: 498 EQQRLAHLEDKLRLLAQARDEAQGACLQQKQVV----------AEAQTR-VSQLGLQVEG 546
Q L + A R +A+ A L+QKQ AE R +Q+ ++
Sbjct: 2158 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2217
Query: 547 LRRRLEELQQELSLKDQE------RVAEVSRVRVELQEQNGRLQAELAAQEALREKAAAL 600
LR +LEE + +L D+E E +R R +++E+ ++ ++ L+ + A
Sbjct: 2218 LRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE 2277
Query: 601 ERQLKVMASDHREALLDRESEN----ASLREKLRLREAEIARIR----DEEAQRASFLQN 652
R L + D+ + L E+E A +L + E AR+R ++ AQ+ + +
Sbjct: 2278 NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK 2337
Query: 653 AVLAYVQA 660
+ +QA
Sbjct: 2338 MLKEKMQA 2345
Score = 85.5 bits (210), Expect = 1e-16
Identities = 131/534 (24%), Positives = 235/534 (44%), Gaps = 102/534 (19%)
Query: 223 AMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASA- 281
A H+Q + +E + + +EV REE + +I ++ +++ +SS A
Sbjct: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVR-REEAAVDAQQQKRSIQEELQQLRQSSEAEIQ 1461
Query: 282 ARVGQLQEALNERHSI---INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQ 338
A+ Q + A R I I ++ +L+ TE +E + Q L AE ++ +Q
Sbjct: 1462 AKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ-AQ 1520
Query: 339 RQAKELKLEQQEAAERE--------SKLLRDLSAANEKNLLLQN------QVDELERKFR 384
+A+ L+ + Q+ ++R+ S++ + AA EK LQ Q +E ER+ R
Sbjct: 1521 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR 1580
Query: 385 CQQEQLFQTRQ--------------EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430
Q ++ + RQ E+ S A + Q E L E Q E++E
Sbjct: 1581 --QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1638
Query: 431 SLRIKEVEHMTRHLEESEKAMQE-RVQRLEAARLSLE-EELSRVKAAALSE--------- 479
R ++ R EE+E+ ++ +++ EA RL L+ EE+++ K+ A +E
Sbjct: 1639 R-RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697
Query: 480 -----RGQAEEELIKAK-----------------SQARLEEQQRLAHL-------EDKLR 510
RG+AEE+ ++ + +Q RL +Q L L E + +
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757
Query: 511 LLAQ--ARDEAQGACLQQKQVVAEAQTRVSQLGLQV-EGLRRRLEELQQELSLKDQERV- 566
LL + AR + + A QK+ EA+ + ++V + R EE + S K ++R+
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1817
Query: 567 AEVSRVRVELQEQNGRLQA---------ELAAQEALREKAAALERQLKV----------M 607
AE R R EL E+ RL+A +LA ++A R++A A ER L +
Sbjct: 1818 AEAGRFR-ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA-ERVLAEKLAAIGEATRL 1875
Query: 608 ASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQAS 661
++ AL ++E+EN LR + R+ ++ AQ + ++ + +AS
Sbjct: 1876 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1929
Score = 81.6 bits (200), Expect = 2e-15
Identities = 108/450 (24%), Positives = 199/450 (44%), Gaps = 65/450 (14%)
Query: 232 TTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
T Q+ Q + + +Q + K LD E + + + E +++R ++V + ++
Sbjct: 2204 TLRQKAQVEQELTTLRLQLEETDHQKNLLD--EELQRLKAEATEAAR-QRSQVEEELFSV 2260
Query: 292 NERHSIINALKAKLQMTEAALALSEQK-----AQDLGELLATAEQEQLSLS---QRQAKE 343
+ ++ LKA+++ AL L ++ Q+ E + +E LS Q A+
Sbjct: 2261 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2320
Query: 344 LKLEQQEAAERES---KLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+L +++ A++ + K+L++ A ++ L+ + + L+++ QEQ + +++ M
Sbjct: 2321 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2380
Query: 401 SAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI--------------------KEVEHM 440
+ +L + L+ E++R + ++E L++ K+ E +
Sbjct: 2381 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI 2440
Query: 441 TRHLEESEKAMQER---VQRLEAARLSLEEELSRVKAAAL-----SERGQAEEELIKAKS 492
L +E A QE+ VQ LE R + + R++ A E+ Q E +L++ KS
Sbjct: 2441 GEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2500
Query: 493 QAR--------LEEQQRL--AHLEDKLRLLAQAR----DEAQGACLQQKQVVAEAQTRVS 538
+ L+E Q L + L +K LL + R ++A+ L Q +V Q R
Sbjct: 2501 EEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE 2560
Query: 539 Q--LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQ--EQNGRLQAELAAQEALR 594
Q Q+E R+RL +E + E V R + ELQ EQ R Q EL A+E R
Sbjct: 2561 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2620
Query: 595 EKAAALERQLKVMASDHREALLDRESENAS 624
L QL+++ HR AL E AS
Sbjct: 2621 -----LREQLQLLEEQHRAALAHSEEVTAS 2645
Score = 76.6 bits (187), Expect = 7e-14
Identities = 118/482 (24%), Positives = 204/482 (42%), Gaps = 64/482 (13%)
Query: 205 LDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLME 264
L + G +VLRA E+ + +Q T E +A L K LR + Q
Sbjct: 1120 LVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKK----LRAQAEAQ----QP 1171
Query: 265 TIDKQREEMAKSSRASAARVGQ-LQEALNERHSIINALKAK----LQMTEAALALSEQKA 319
T D R+E+ A VG+ LQ+ ER + + + L+ +A LA ++ +
Sbjct: 1172 TFDALRDELR-----GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1226
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKL----LRDLSAANEKNLLLQNQ 375
++L +L QL + A L Q+A R+ ++ L D A E+ Q
Sbjct: 1227 RELEQL-----GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQAL 1281
Query: 376 VDELERKFRCQQE-QLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434
++E+ER +E Q F + EL++ +A+ + + SES+
Sbjct: 1282 LEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1341
Query: 435 KEVEHMTRHLE-------------ESEKAMQERVQRLEAARLSLEEELSRVKAAALSERG 481
+ V+ T + E E+ + M+E + E R E L+ V+AA +R
Sbjct: 1342 EYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR- 1400
Query: 482 QAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+L +A +QA+ + ++ L+ +++ R+EA QQK+ + E ++ Q
Sbjct: 1401 ----QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSS 1456
Query: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQE-QNGRLQAELAAQEALREKAAAL 600
+ R E + L+ +E + V R+++E E Q G + EL A A E+A A
Sbjct: 1457 EAEIQAKARQAEAAERSRLRIEEEI-RVVRLQLEATERQRGGAEGELQALRARAEEAEAQ 1515
Query: 601 ERQLKVMASDHREALLDR---------------ESENASLREKLR-LREAEIARIRDEEA 644
+RQ + A R + D ++E + REK R L+ E R++ EEA
Sbjct: 1516 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1575
Query: 645 QR 646
+R
Sbjct: 1576 ER 1577
Score = 72.0 bits (175), Expect = 2e-12
Identities = 107/446 (23%), Positives = 196/446 (43%), Gaps = 68/446 (15%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
D + +Q +Q T + + R +S E + L+ ++ M + EE A
Sbjct: 2376 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-----MSRAQARAEEDA 2430
Query: 275 KSSRASAARVGQ----LQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE 330
+ R A +G+ + A E+ +++ L+ + Q S+ A+ L E +A E
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQ-------SDHDAERLREAIAELE 2483
Query: 331 QEQLSLSQRQAKELKLEQQE-AAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQ 389
+E+ L Q++AK L+L+ +E ++ +LL++ A + L ++ + + ER ++ +
Sbjct: 2484 REKEKL-QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2542
Query: 390 LFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEK 449
L Q Q+ + + +L+ + +++++ E++R S+E E EE +
Sbjct: 2543 LEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME--------EARRRQHEAEEGVR 2594
Query: 450 AMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQR--LAHLED 507
QE +Q+LE R EE L+E Q E ++ LEEQ R LAH E+
Sbjct: 2595 RKQEELQQLEQQRRQQEE--------LLAEENQRLREQLQL-----LEEQHRAALAHSEE 2641
Query: 508 -------KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSL 560
+ L RD G AEA+ S GL+ + +RL+E LS
Sbjct: 2642 VTASQVAATKTLPNGRDALDGP-------AAEAEPEHSFDGLRRKVSAQRLQE-AGILSA 2693
Query: 561 KDQERVA-------EVSR---VRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASD 610
++ +R+A E++R VR LQ ++ L A AAL+RQL ++
Sbjct: 2694 EELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQL--LSPG 2751
Query: 611 HREALLDRESENASLREKLRLREAEI 636
LL+ ++ + L + +R R +
Sbjct: 2752 TALILLEAQAASGFLLDPVRNRRLTV 2777
Score = 34.7 bits (78), Expect = 0.29
Identities = 72/334 (21%), Positives = 139/334 (41%), Gaps = 44/334 (13%)
Query: 285 GQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKEL 344
G+L A+ ER + + +L+ + + + +A E L A+ + Q+
Sbjct: 398 GKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD------ALLQSDVR 451
Query: 345 KLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQL----FQTRQEMTSM 400
L + +R ++ RDL A+ LL N V L+ Q EQ+ ++ + + ++
Sbjct: 452 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 511
Query: 401 SAELKMR-----AIQAEE--RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE 453
E +R A A + ++ ++ + R LEDS R+L++ ++E
Sbjct: 512 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDS----------TLRYLQDLLAWVEE 561
Query: 454 RVQRLEAARLSLEEELSRVKAAALSERG--QAEEELIKAKSQARLEEQQRLAHLEDKLRL 511
R++ A + +L V+A S RG Q+ EE +AR +E Q L R
Sbjct: 562 NQHRVDGAEWGV--DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQ----LSPATR- 614
Query: 512 LAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSR 571
RD LQ +++ ++ R+ L E L + +EL +++ EV
Sbjct: 615 -GAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAAATKELMWLNEKEEEEVG- 668
Query: 572 VRVELQEQNGRLQAELAAQEALREKAAALERQLK 605
+ ++N + A+ + AL + E+++K
Sbjct: 669 --FDWSDRNTNMTAKKESYSALMRELELKEKKIK 700
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 96.7 bits (239), Expect = 6e-20
Identities = 125/480 (26%), Positives = 227/480 (47%), Gaps = 77/480 (16%)
Query: 217 LRAVEQAMGHSQDRLTTFQEN----------------------QARTHVLSKEVQHLREE 254
L+A ++ + +DRL QE+ + + VL+KE+ +RE
Sbjct: 629 LQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREA 688
Query: 255 KSKQFLDLMETIDKQREEMAKS-SRASAARVGQLQEALNERHSIINALKAKLQMTEAAL- 312
S+ L + + ++ E+A++ ++A A RV +L+ ++ + + A +A LQ + + L
Sbjct: 689 LSRATLQ-RDMLQAEKAEVAEALTKAEAGRV-ELELSMTK----LRAEEASLQDSLSKLS 742
Query: 313 ALSEQKAQ---DLGELLATAEQEQLSLS--QRQA--------------KELKLEQQEAAE 353
AL+E AQ DL L+A E+E+ +L QRQA +EL+LEQ+ A +
Sbjct: 743 ALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQ 802
Query: 354 RESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEE 413
LR A E L+ Q+ L + QEQL Q ++++ EL+ +A+
Sbjct: 803 GLEGSLRVAEQAQE---ALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQR 859
Query: 414 RLDMEKRRCRQS---LEDSESLRIKEV--EHMTRHLEESEKAMQERVQRLEAARLSLEEE 468
+++ +R R+ ++ L ++ V E R L E ++ + LE + ++ +
Sbjct: 860 QVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQ 919
Query: 469 LSRVKAAALSERGQAEEELIKAKSQARLEEQQ----RLAHLEDKLRLLAQARDEAQGACL 524
L+++ +A E ++A+ QA L ++ LA L ++ + Q + +
Sbjct: 920 LAQL---------EARREQLEAEGQALLLAKETLTGELAGLRQQI-IATQEKASLDKELM 969
Query: 525 QQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQ 584
QK V AE + + S L Q L+ LQ+E +E AE ++++ +LQ + L
Sbjct: 970 AQKLVQAEREAQAS-LREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELL 1028
Query: 585 AELAAQ-EALREKAAALERQ----LKVMASDHREALLDRESENASLREKLRLREAEIARI 639
A L A+ E L E+ AAL+++ L + S+ ++AL +ESE +L EKL +A I
Sbjct: 1029 ARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATI 1088
Score = 93.2 bits (230), Expect = 7e-19
Identities = 109/458 (23%), Positives = 203/458 (44%), Gaps = 46/458 (10%)
Query: 222 QAMGHSQDRLTTFQENQART-HVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRAS 280
Q + + + L+ + N A + V ++ + LR+E+ K E + +QR+ + + +
Sbjct: 592 QRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREK-LQAAQEELRRQRDRLEEEQEDA 650
Query: 281 AARVGQLQEALNERHSIINALKAKL-----QMTEAALALSEQKAQ---------DLGELL 326
+++ L H + L+ K ++ E ALS Q ++ E L
Sbjct: 651 VQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEAL 710
Query: 327 ATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQ 386
AE ++ L + KL +EA+ ++S L LSA NE L Q+++D + +
Sbjct: 711 TKAEAGRVEL---ELSMTKLRAEEASLQDS--LSKLSALNES--LAQDKLDLNRLVAQLE 763
Query: 387 QEQ-LFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKE--------- 436
+E+ Q RQ A + + E L +E+ RQ LE S LR+ E
Sbjct: 764 EEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGS--LRVAEQAQEALEQQ 821
Query: 437 ---VEHMTRHLEES----EKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIK 489
+ H L+E + + R Q LE AR + ++ ++ AA + A+E
Sbjct: 822 LPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGL 881
Query: 490 AKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRR 549
A E + R L ++ L ++ +G+ + ++ +A+ + R QL + + L
Sbjct: 882 AVQLVAAEREGRT--LSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLL 939
Query: 550 RLEELQQELSLKDQERVAEVSRVRVELQEQNGRL-QAELAAQEALREKAAALERQLKVMA 608
E L EL+ Q+ +A + ++ + +L QAE AQ +LRE+ AA E L+ +
Sbjct: 940 AKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQ 999
Query: 609 SDHREALLDRESENASLREKLRLREAE-IARIRDEEAQ 645
+ A + E+E A L+ +L+ + E +AR+ E+ +
Sbjct: 1000 REKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEE 1037
Score = 85.1 bits (209), Expect = 2e-16
Identities = 128/479 (26%), Positives = 217/479 (45%), Gaps = 72/479 (15%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHV-LSKEVQHLREEKS-----KQFLDLMETIDKQR 270
LRA E ++ S +L+ E+ A+ + L++ V L EEKS ++ + T+ ++
Sbjct: 727 LRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE 786
Query: 271 EEMAKSSRAS--AARVG---------QLQEALNERHSIINALKAKLQMTEAALALSEQKA 319
+E + R AR G Q QEAL ++ + +++LQ A L+
Sbjct: 787 QERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGR 846
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQE---------AAERESKLLRDLSAAN--EK 368
+ E Q Q+ +R A+E + +E AAERE + L + + EK
Sbjct: 847 EQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEK 906
Query: 369 NLL------LQNQVDELERK---FRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEK 419
L +Q Q+ +LE + + + L ++ +T A L+ + I +E+ ++K
Sbjct: 907 EALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDK 966
Query: 420 RRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSE 479
Q L +E L E A +E +QRL+ + + EL +A S+
Sbjct: 967 ELMAQKLVQAE-------REAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQ 1019
Query: 480 RGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACL---QQKQVVAEAQTR 536
+ +EEL+ ARLE ++ L +++ L Q RDE G L +++Q ++ ++
Sbjct: 1020 LQREQEELL-----ARLEAEKE--ELSEEIAALQQERDE--GLLLAESEKQQALSLKESE 1070
Query: 537 VSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREK 596
+ L ++ G R L + L ++ Q+R A+ SR + N L +EL A RE+
Sbjct: 1071 KTALSEKLMGTRHSLATI--SLEMERQKRDAQ-SRQEQDRSTVNA-LTSELRDLRAQREE 1126
Query: 597 AAALE----RQLKVMASD---HREALLDRESENASLREKLRLREAEIARIRDE--EAQR 646
AAA R+L+ A D R++ L RE+E LR +LRL E +R E EAQR
Sbjct: 1127 AAAAHAQEVRRLQEQARDLGKQRDSCL-REAE--ELRTQLRLLEDARDGLRRELLEAQR 1182
Score = 79.0 bits (193), Expect = 1e-14
Identities = 96/394 (24%), Positives = 181/394 (45%), Gaps = 43/394 (10%)
Query: 295 HSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAER 354
HS ++ + ++Q S+ L + L+ +E E+ +L + Q + L+ + A +
Sbjct: 525 HSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEE-QLQRLRDKTDGAMQA 583
Query: 355 ESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSA---ELKMR---- 407
R++ N LL + L + Q+Q + RQE + A EL+ +
Sbjct: 584 HEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRL 643
Query: 408 ------AIQAEERLDMEKRRCRQSLEDSESLR------IKEVEH------MTRHLEESEK 449
A+Q R+ E R + LE E R + EV + R + ++EK
Sbjct: 644 EEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEK 703
Query: 450 A-MQERVQRLEAARLSLEEELSRVKA--AALSERGQAEEELIKAKSQARLEEQQRLAHLE 506
A + E + + EA R+ LE +++++A A+L + L ++ +Q +L+ + +A LE
Sbjct: 704 AEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLE 763
Query: 507 DKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLE---ELQQELSLKDQ 563
++ L + +A+ Q+ V E Q R+ +L L+ E R+ LE + ++ +
Sbjct: 764 EEKSALQGRQRQAE----QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819
Query: 564 ERVAEVSRVRVELQEQNGRLQAELAAQEALREKA-AALERQLKVM--ASDHREALLDRES 620
+++ + R +LQEQ +L +L+ +E E+A +RQ++ + A+ +EAL
Sbjct: 820 QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEAL---AK 876
Query: 621 ENASLREKLRLREAEIARIRDEEAQRASFLQNAV 654
E+A L +L E E R EEA R + A+
Sbjct: 877 EHAGLAVQLVAAERE-GRTLSEEATRLRLEKEAL 909
Score = 79.0 bits (193), Expect = 1e-14
Identities = 104/437 (23%), Positives = 186/437 (42%), Gaps = 57/437 (13%)
Query: 246 KEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKL 305
+ Q R+E Q +++Q EM ++ +R QLQ+A+ E ++ +L
Sbjct: 1519 RSAQRERDELRTQ----TSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRL 1574
Query: 306 QMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAA 365
+A LAL E+ + + + + +L Q E L+ E+ +L A+
Sbjct: 1575 SGVQAELALQEESVR------RSERERRATLDQVATLERSLQATES---------ELRAS 1619
Query: 366 NEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAE---ERLDMEKRRC 422
EK ++ +LE R +E L E ++ EL+ R+++ E RL + R
Sbjct: 1620 QEKISKMKANETKLEGDKRRLKEVL--DASESRTVKLELQRRSLEGELQRSRLGLSDREA 1677
Query: 423 R-QSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERG 481
+ Q+L+D R+ ++ E +Q V+RL A +EE AL ++
Sbjct: 1678 QAQALQD----RVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEE-----SEGALRDKV 1728
Query: 482 QAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+ E + S + + + HL+ L R Q +Q ++EA+ + S LG
Sbjct: 1729 RGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLG 1788
Query: 542 LQVEGLRRRLEELQQELSLKDQERVAEVSRVRVEL-QEQNGRLQAELAAQE------ALR 594
QV+ LR + +L+ L+ E ++ ++R L Q Q G A Q+ L+
Sbjct: 1789 EQVQTLRGEVADLE----LQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRLLQ 1844
Query: 595 EKAAALERQLKVMASDHRE---ALLDRESENASL--------REKLRLREAEIARIRDEE 643
E+ +L+R L + ++ RE + L E + +L REKLR E + R+ E+
Sbjct: 1845 ERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHE-DTVRLSAEK 1903
Query: 644 AQRASFLQNAVLAYVQA 660
+ L A L +A
Sbjct: 1904 GRLDRTLTGAELELAEA 1920
Score = 78.2 bits (191), Expect = 2e-14
Identities = 107/426 (25%), Positives = 188/426 (44%), Gaps = 78/426 (18%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
L+A E + SQ++++ + N+ + L +K + L E +D K
Sbjct: 1609 LQATESELRASQEKISKMKANETK----------LEGDKRR----LKEVLDASESRTVKL 1654
Query: 277 SRASAARVGQLQEA---LNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQ 333
+ G+LQ + L++R + AL+ ++ + +A SE KA G L T E+
Sbjct: 1655 ELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKA---GTLQLTVERLN 1711
Query: 334 LSLSQRQAKE--LKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLF 391
+L++ + E L+ + + E ++ L++ +KNL LQ + E + QE+L
Sbjct: 1712 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD 1771
Query: 392 QTRQEMTSMS-----------------AELKMRAIQAEERLDMEKRRCRQSLEDSESLRI 434
RQ ++ A+L+++ ++AE +L + RQ ++ E+ +
Sbjct: 1772 AARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR-QEGEAAAL 1830
Query: 435 KEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQA 494
V+ L++ + +QER+ L+ A LE E V+ +AL + E++ + +
Sbjct: 1831 NTVQK----LQDERRLLQERLGSLQRALAQLEAEKREVERSAL----RLEKDRVALRRTL 1882
Query: 495 RLEEQQRLAHLEDKLRL-----------------LAQARD-----EAQGACLQQKQVVA- 531
E+++L ED +RL LA+A+ EAQ L+Q A
Sbjct: 1883 DKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQ 1942
Query: 532 -EAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQ----NGRLQAE 586
E + QL LQ E R R + Q E +L+ +ER A RVR L+EQ G+LQ E
Sbjct: 1943 LEVDAQQQQLELQQEVERLRSAQAQTERTLEARER-AHRQRVR-GLEEQVSTLKGQLQQE 2000
Query: 587 LAAQEA 592
L A
Sbjct: 2001 LRRSSA 2006
Score = 76.6 bits (187), Expect = 7e-14
Identities = 99/466 (21%), Positives = 199/466 (42%), Gaps = 60/466 (12%)
Query: 221 EQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRAS 280
EQ H +D +E +A L E L+ + ++ +L+ ++ ++EE+++ A
Sbjct: 986 EQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAAL 1045
Query: 281 AAR--------VGQLQEALNERHSIINALKAKLQMTEAALA-----LSEQK--------- 318
+ Q+AL+ + S AL KL T +LA + QK
Sbjct: 1046 QQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQ 1105
Query: 319 --------AQDLGELLATAEQ------EQLSLSQRQAKELKLEQQEAAERESKLLRDLSA 364
+L +L A E+ +++ Q QA++L ++ +L L
Sbjct: 1106 DRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRL 1165
Query: 365 ANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQ 424
+ L+ ++ E +RK R QE RQE + L A + E L R
Sbjct: 1166 LEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGA-KEREALRRSNEELRS 1224
Query: 425 SLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALS---ERG 481
+++ +ES RI L+ + + ++++ LE AR ++ +E ++ R
Sbjct: 1225 AVKKAESERIS--------LKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRL 1276
Query: 482 QAEEELIKAKSQARLEEQQ------RLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQT 535
+A EL + + Q ++ + + LA L+ +L L +A E++ L +Q + + +
Sbjct: 1277 EARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEA 1336
Query: 536 RVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVR-VELQEQNGRLQAELAAQEALR 594
+ + +++ +R+L+E + E +++ + + R E Q+ + EL + A
Sbjct: 1337 SLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAA-- 1394
Query: 595 EKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIR 640
+A A E L++ A++ R L E+E A + + R EA++ +R
Sbjct: 1395 -RAEAAELGLRLSAAEGRAQGL--EAELARVEVQRRAAEAQLGGLR 1437
Score = 63.5 bits (153), Expect = 6e-10
Identities = 76/318 (23%), Positives = 145/318 (45%), Gaps = 31/318 (9%)
Query: 346 LEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELK 405
L++ +A+RE LR ++A + L + + + R +Q Q E S + +
Sbjct: 1515 LQELRSAQRERDELRTQTSALNRQLA-EMEAERDSATSRARQLQKAVAESEEARRSVDGR 1573
Query: 406 MRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSL 465
+ +QAE L E R + + ++ +E + E +A QE++ +++A L
Sbjct: 1574 LSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRASQEKISKMKANETKL 1633
Query: 466 EEELSRVKAAALSERGQAEEELIKAKSQ-ARLEEQQRLAHLEDKLRLLAQARDEAQGACL 524
E + R+K E L ++S+ +LE Q+R E + L + EAQ L
Sbjct: 1634 EGDKRRLK-----------EVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQAL 1682
Query: 525 QQK-----QVVAEAQTRVSQLGLQVEGLRRRLEELQQ-ELSLKDQ-----ERVAEVSRVR 573
Q + + VA+++ + L L VE L L ++++ E +L+D+ E +A+ S
Sbjct: 1683 QDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSASL 1742
Query: 574 VELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLRE 633
+++N LQ L A E R+ L+ +L R+AL + +++SL E+++
Sbjct: 1743 NSTRDKNLHLQKALTACEHDRQ---VLQERLDAA----RQALSEARKQSSSLGEQVQTLR 1795
Query: 634 AEIARIRDEEAQRASFLQ 651
E+A + + + LQ
Sbjct: 1796 GEVADLELQRVEAEGQLQ 1813
Score = 51.2 bits (121), Expect = 3e-06
Identities = 88/396 (22%), Positives = 165/396 (41%), Gaps = 51/396 (12%)
Query: 279 ASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQ 338
AS + + + L + S + L A+ + LA+ + E E +L +
Sbjct: 74 ASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQE 133
Query: 339 -----RQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQT 393
RQ+ EL+ + Q E ++ R L A E V L+ K +++ +
Sbjct: 134 PRGLVRQSVELRRQLQ---EEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSEL 190
Query: 394 RQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE 453
Q++ S EL+ + ++ E Q LE S +R++E + + L + ++E
Sbjct: 191 EQQLLERSGELEQQRLRDTEH--------SQDLE-SALIRLEEEQQRSASLAQVNAMLRE 241
Query: 454 RVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLA 513
++ + +A +L E++ +V ++ + +EL ++ R EE+ A+ ++ L
Sbjct: 242 QLDQAGSANQALSEDIRKV----TNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLL 297
Query: 514 QARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQE--LSLKDQERVAEVSR 571
+ G +++V+E + + LQ+ G R QE L L R+AE SR
Sbjct: 298 LLWRQVVGF----RRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAE-SR 352
Query: 572 VRVELQEQNGRLQAELAAQ---EALREKAAALER---------------QLKVMASDHRE 613
L++Q LQA+L Q + LREK A ++ +L + +
Sbjct: 353 AEAALEKQ-ALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEK 411
Query: 614 ALLDRESENASLREKLR----LREAEIARIRDEEAQ 645
L+++ N L EKL LR E A + E+ +
Sbjct: 412 QNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGE 447
Score = 50.1 bits (118), Expect = 7e-06
Identities = 76/300 (25%), Positives = 131/300 (43%), Gaps = 45/300 (15%)
Query: 362 LSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRR 421
L+ A E L L+ + LE CQ++ L ++ + ++ ++ A + +
Sbjct: 5 LARAQEVELTLETVIQTLESSVLCQEKGL-----GARDLAQDAQITSLPA-----LIREI 54
Query: 422 CRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERG 481
++L ES + M L ++QE Q L+ +ELSRV+ R
Sbjct: 55 VTRNLSQPESPVLLPATEMASLL-----SLQEENQLLQ-------QELSRVEDLLAQSRA 102
Query: 482 QAEEELIKAKS-QARLEEQQRL--AHLEDK-----LRLLAQAR---DEAQGACLQQKQVV 530
+ +E IK + RLE+ RL LE + +R + R E Q + ++ Q
Sbjct: 103 ERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAY 162
Query: 531 AEAQTRVSQLGLQVEG----LRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAE 586
E Q R +QL +++G ++R EL+Q+L ER E+ + R+ E + L++
Sbjct: 163 QEGQQRQAQLVQRLQGKILQYKKRCSELEQQL----LERSGELEQQRLRDTEHSQDLESA 218
Query: 587 LAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQR 646
L E ++++A+L Q+ M RE L S N +L E +R + R R E R
Sbjct: 219 LIRLEEEQQRSASL-AQVNAML---REQLDQAGSANQALSEDIRKVTNDWTRCRKELEHR 274
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 96.3 bits (238), Expect = 8e-20
Identities = 121/443 (27%), Positives = 198/443 (44%), Gaps = 65/443 (14%)
Query: 229 DRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQ 288
D L+T QE A T SKEV L L+ +Q+E ++ AR G Q
Sbjct: 900 DDLSTLQEKMAAT---SKEVARLET--------LVRKAGEQQETASRELVKEPARAGDRQ 948
Query: 289 -EALNERHSIINALKAKLQMTEAALALSEQKAQDLG---ELLATAEQEQLSLSQ----RQ 340
E L E+ + T+AAL E++A+ +G E L A E Q +Q
Sbjct: 949 PEWLEEQQG------RQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ 1002
Query: 341 AKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+E+ QE ++ L + +A E + LQN ++E +F QE L E
Sbjct: 1003 EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK 1062
Query: 401 SAEL-KMRAIQAEERLDMEKRRCRQSLED-SESLRIKEVEHMTRHLEESEKA--MQERVQ 456
EL K+R ++A + ++E+ RQ+++ E L KE EH + +SE A +
Sbjct: 1063 DQELAKLRGLEAAQIKELEE--LRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGP 1120
Query: 457 RLEAARLSLEEELSRVKAAALSERGQAE--EELIKAKSQARLEEQQRLAHLEDKLRLLAQ 514
+LEA R E+S+++ ++ QA+ E ++A+ +R E L L+ +L AQ
Sbjct: 1121 KLEALRA----EVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQ 1176
Query: 515 ARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRV 574
+Q A ++ +A +T+V Q+ S + E A+V+R R
Sbjct: 1177 ELGHSQSALASAQRELAAFRTKV------------------QDHSKAEDEWKAQVARGRQ 1218
Query: 575 ELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHRE--ALLDRESENA-SLREKLRL 631
E + +N + +L E+ + L RQ+ + +E L+ ESE + L E+LRL
Sbjct: 1219 EAERKNSLI-------SSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRL 1271
Query: 632 REAEIARIRDEEAQRASFLQNAV 654
+AE A A+R+S L+ V
Sbjct: 1272 LQAETASNSARAAERSSALREEV 1294
Score = 92.0 bits (227), Expect = 2e-18
Identities = 139/551 (25%), Positives = 235/551 (42%), Gaps = 114/551 (20%)
Query: 198 SNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSK 257
SNR L+LA N A M DRL E QA + + KE++ LR++
Sbjct: 228 SNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNES 287
Query: 258 QFLDLMETI-------------DKQREEMAKSS-------RASAARVGQLQEALN---ER 294
+ L ET+ D++ ++++ + R A+ + QLQ+ALN E
Sbjct: 288 LTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEE 347
Query: 295 HSII-----------------------------NALKAKLQMTEAALA-LSEQKAQDLGE 324
HS L+ KL E L+ L + Q+ GE
Sbjct: 348 HSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGE 407
Query: 325 LLA------TAEQEQLSL----SQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQN 374
+L T +QE +L +Q QA+ +++ + E ++E+KLL + E+ L +
Sbjct: 408 VLGDVLQLETLKQEAATLAANNTQLQAR-VEMLETERGQQEAKLLAERGHFEEEKQQLSS 466
Query: 375 QVDELE---RKFRCQQEQLFQTRQ---------------EMTSMSA-------ELKMRAI 409
+ +L+ +E+L Q Q E+T+++A EL
Sbjct: 467 LITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQ 526
Query: 410 QAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEEL 469
QA+E+ + +Q + S+ LR +VE ++ L++ E+ ++E ++ EA R ++L
Sbjct: 527 QAKEKQAQLAQTLQQQEQASQGLR-HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQL 585
Query: 470 SRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLE---DKLRLLAQARDEAQGACLQQ 526
A A ER + E A Q E+++ A LE +L++ +ARD AQ + Q
Sbjct: 586 ----ATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQA 641
Query: 527 KQVVAEAQTRVSQLGLQVEGLRRRLEELQQ-----ELSLK-DQERVAEVSRVRVE---LQ 577
++ AE +V +L VE R+ E Q EL L+ +Q++ E RV E LQ
Sbjct: 642 QREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQ 701
Query: 578 EQNGRLQAEL-----AAQEALREKAAALERQ---LKVMASDHREALLDRESENASLREKL 629
EQ L+ L + +E R A ALE Q + + ++ R + + E L E+
Sbjct: 702 EQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEER 761
Query: 630 RLREAEIARIR 640
R+ AR++
Sbjct: 762 AGRKGLEARLQ 772
Score = 81.6 bits (200), Expect = 2e-15
Identities = 113/496 (22%), Positives = 220/496 (44%), Gaps = 58/496 (11%)
Query: 228 QDRLTTFQEN--QARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASA---- 281
++ L+ Q+N Q + VL +Q ++ L T + R EM ++ R
Sbjct: 391 EEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKL 450
Query: 282 -ARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLA------TAEQEQL 334
A G +E + S+I L++ + A EQ +Q G L T+E L
Sbjct: 451 LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL 510
Query: 335 SLS-QRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQT 393
+ + Q+Q +EL +Q+A E++++L + L + + L++QV++L + +++QL +
Sbjct: 511 NATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEV 570
Query: 394 --RQEMTSMSAELKMRAIQAEERLDMEKR----RCRQSLEDSESLRIKEVEHMTRHLEES 447
+QE T ++ E + +R + ++LE ++ +++ ++ + E+
Sbjct: 571 AEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 448 EKAMQERVQRLEAARLSLE---EELSRVKAAALSERGQAEEELIKAKSQARLEEQ----- 499
+ Q V + + + L EEL A E+ +A+ ++ + + Q R E+Q
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEK 690
Query: 500 QRLAHLEDKLRLLAQARDEA----QGACLQQKQVVAEA----QTRVSQLGLQVEGL---- 547
+R+A +D+L+ QA E+ +G+ ++K+ A+A Q +S+L + L
Sbjct: 691 ERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH 750
Query: 548 ---RRRLEE-------LQQELSLKDQERVAEVSRVRVELQE-QNGRLQAELAAQEALREK 596
R+ LEE L+ L + AE +R EL E + AE ++ ++E
Sbjct: 751 KRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEV 810
Query: 597 AAALERQLKVMASD------HREALLDRESENASLREKLRLREAEIARIRDEEAQRASFL 650
AA ER + +E L+ + E R++L+ + ++A I + S
Sbjct: 811 AAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQ 870
Query: 651 QNAVLAYVQASPVRTL 666
QN LA + A+ R L
Sbjct: 871 QNE-LAELHANLARAL 885
Score = 80.1 bits (196), Expect = 6e-15
Identities = 120/437 (27%), Positives = 187/437 (42%), Gaps = 69/437 (15%)
Query: 240 RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIIN 299
R+ L +EVQ LREE KQ + + R+E+ S A +GQ +A E+
Sbjct: 1286 RSSALREEVQSLREEAEKQRV----ASENLRQELT-SQAERAEELGQELKAWQEKFFQKE 1340
Query: 300 ALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLL 359
+ LQ+ + + L + EQ + +R +EL+ +Q A ++LL
Sbjct: 1341 QALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL 1400
Query: 360 RDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKM----RAIQAEERL 415
R A E L+ L +K Q+ Q R E S + +L M + AEE
Sbjct: 1401 R---AQRELGELI-----PLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452
Query: 416 DMEKRR--CRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVK 473
+ +R RQ LE E ++A ++ VQ L A R E L+ V+
Sbjct: 1453 GLGERANLGRQFLE-----------------VELDQAREKYVQELAAVRADAETRLAEVQ 1495
Query: 474 AAALSERGQAEEELIKAKSQAR----LEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQV 529
A S E E++ AK + LEE+QR E++ +L AQ ++Q +V
Sbjct: 1496 REAQST--ARELEVMTAKYEGAKVKVLEERQRFQ--EERQKLTAQ---------VEQLEV 1542
Query: 530 VAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQA---E 586
QT+ QVE L ++L + Q S Q+++ V E Q++ RLQA E
Sbjct: 1543 FQREQTK------QVEELSKKLADSDQ-ASKVQQQKLKAVQAQGGESQQEAQRLQAQLNE 1595
Query: 587 LAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLRE---AEIARIRDEE 643
L AQ + +E+AA + A H +A ++ +N L+E+LR E E +R E
Sbjct: 1596 LQAQLSQKEQAAEHYKLQMEKAKTHYDA---KKQQNQELQEQLRSLEQLQKENKELRAEA 1652
Query: 644 AQRASFLQNAVLAYVQA 660
+ LQ A L +A
Sbjct: 1653 ERLGHELQQAGLKTKEA 1669
Score = 73.6 bits (179), Expect = 6e-13
Identities = 101/405 (24%), Positives = 181/405 (44%), Gaps = 67/405 (16%)
Query: 234 FQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNE 293
F QA + +E + + E + LME+ +Q+EE + R AR+ Q +
Sbjct: 960 FCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQER-EVARLTQERGRAQA 1018
Query: 294 RHSIINALKAKLQMTEAALALSEQKAQ--DLGELLATAEQEQLSLSQRQAKELKLEQQEA 351
++ A +A+L+M AL+EQ+ + L E LA A L ++E
Sbjct: 1019 DLALEKAARAELEM-RLQNALNEQRVEFATLQEALAHA----------------LTEKEG 1061
Query: 352 AERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAEL------- 404
++E LR L AA K L +EL + + +EQL + +E S S
Sbjct: 1062 KDQELAKLRGLEAAQIKEL------EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRT 1115
Query: 405 -----KMRAIQAEERLDMEKRRCRQSLEDSESL-RIKEVEHMTRH-----LEESEKAMQE 453
K+ A++AE + +++C++ E ++SL R E E +R LE + ++E
Sbjct: 1116 EPTGPKLEALRAE--VSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 1173
Query: 454 RVQRL---EAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQR---LAHLED 507
+ Q L ++A S + EL+ + + + +AE+E ++ R E +++ ++ LE+
Sbjct: 1174 KAQELGHSQSALASAQRELAAFRTK-VQDHSKAEDEWKAQVARGRQEAERKNSLISSLEE 1232
Query: 508 KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVA 567
++ +L + E +G + K++V A++ SQ L RL LQ E +
Sbjct: 1233 EVSILNRQVLEKEGESKELKRLVM-AESEKSQK------LEERLRLLQAETASNSARAAE 1285
Query: 568 EVSRVRVELQEQNGRLQAELAAQEALR-------EKAAALERQLK 605
S +R E+Q + + A E LR E+A L ++LK
Sbjct: 1286 RSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELK 1330
Score = 68.6 bits (166), Expect = 2e-11
Identities = 97/450 (21%), Positives = 181/450 (40%), Gaps = 70/450 (15%)
Query: 235 QENQARTHVLSKEV------QHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQ 288
+ +QA T VL +E+ QH E + +Q L++ + RE S + A Q
Sbjct: 776 EAHQAETEVLRRELAEAMAAQHTAESECEQ---LVKEVAAWRERYEDSQQEEAQYGAMFQ 832
Query: 289 EALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQ 348
E L LK + E+ Q+L E A+++ + ++ +Q
Sbjct: 833 EQLM-------TLKEEC----------EKARQELQE----AKEKVAGIESHSELQISRQQ 871
Query: 349 QEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRA 408
E AE + L R L EK + Q D+L QE++ T +E+ + ++
Sbjct: 872 NELAELHANLARALQQVQEKEVRAQKLADDLSTL----QEKMAATSKEVARLETLVRKAG 927
Query: 409 IQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEE 468
Q E R+ +++ ++ E + + Q +Q +E + E
Sbjct: 928 EQQETA-------SRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNE 980
Query: 469 LSRVKAAALSERGQAEEEL--------------------IKAKSQARLEEQQRLAHLEDK 508
L R++AA + +GQ +EE + + AR E + RL + ++
Sbjct: 981 LERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNE 1040
Query: 509 LRLLAQARDEAQGACLQQK----QVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQE 564
R+ EA L +K Q +A+ + + ++E LR+ +++L+++L+ K++E
Sbjct: 1041 QRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100
Query: 565 RVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENAS 624
+ E GR + EALR + + LE+Q + E+E AS
Sbjct: 1101 HASGSG----AQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS 1156
Query: 625 LREKLRLREAEIARIRDEEAQRASFLQNAV 654
E+ E ++ +E+AQ Q+A+
Sbjct: 1157 RAERDSALETLQGQL-EEKAQELGHSQSAL 1185
Score = 63.5 bits (153), Expect = 6e-10
Identities = 92/376 (24%), Positives = 167/376 (44%), Gaps = 54/376 (14%)
Query: 314 LSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNL--- 370
LS A +G++L T + + +R K+L E+ E E +L + EK+
Sbjct: 197 LSGSPASPMGDILQTPQFQM----RRLKKQLADERSNRDELELELAENRKLLTEKDAQIA 252
Query: 371 LLQNQVDEL------ERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEK----R 420
++Q ++D L + + ++L + R + S++ L Q ++ L EK R
Sbjct: 253 MMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD-LKTEKSQMDR 311
Query: 421 RCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSER 480
+ Q E++ L K + HL++ + A+ E L EE S+ L ++
Sbjct: 312 KINQLSEENGDLSFK-LREFASHLQQLQDALNE-----------LTEEHSKATQEWLEKQ 359
Query: 481 GQAEEELIKAKSQAR-LEE-----QQRLAHLEDKLRLL----AQARDEAQGACLQQKQVV 530
Q E+EL A + LEE Q +L+ LE+ L L Q + E G LQ + +
Sbjct: 360 AQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLK 419
Query: 531 AEAQTRV---SQLGLQVEGLRRRLEELQQELSL-----KDQERVAEVSRVRVELQEQNGR 582
EA T +QL +VE L E QQE L +E ++S + +LQ
Sbjct: 420 QEAATLAANNTQLQARVEML--ETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISN 477
Query: 583 L-QAELAAQEALREKAAALERQLKVMASD---HREALLDRESENASLREKLRLREAEIAR 638
L QA+ ++A + A L Q+ + S+ + ++ E A L+++ + ++A++A+
Sbjct: 478 LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQ 537
Query: 639 IRDEEAQRASFLQNAV 654
++ Q + L++ V
Sbjct: 538 TLQQQEQASQGLRHQV 553
Score = 58.2 bits (139), Expect = 2e-08
Identities = 102/423 (24%), Positives = 187/423 (44%), Gaps = 62/423 (14%)
Query: 214 GDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEM 273
G L+A ++ + L+T Q T L E+ + + + + REE+
Sbjct: 1326 GQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREEL 1385
Query: 274 AKSSRASAARVGQLQEALNERHSII----------------NALKA----KLQMTEAALA 313
+S +A+ +L A E +I A KA +L M + A
Sbjct: 1386 EQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHG 1445
Query: 314 LSEQKAQDLGELLATAEQE-QLSLSQRQAK---ELKLEQQEAAERESKLLRDL-SAANEK 368
L ++ + LGE Q ++ L Q + K EL + +A R +++ R+ S A E
Sbjct: 1446 LLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAREL 1505
Query: 369 NLLLQN----QVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQ 424
++ +V LE + R Q+E RQ++T+ +L++ Q E+ +E+ +
Sbjct: 1506 EVMTAKYEGAKVKVLEERQRFQEE-----RQKLTAQVEQLEV--FQREQTKQVEE--LSK 1556
Query: 425 SLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAE 484
L DS+ K + + ++ Q+ QRL+A L+ +LS+ + AA + Q E
Sbjct: 1557 KLADSDQAS-KVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQME 1615
Query: 485 EELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG--L 542
KAK+ ++QQ L+++LR L Q + E K++ AEA+ +LG L
Sbjct: 1616 ----KAKTHYDAKKQQN-QELQEQLRSLEQLQKE-------NKELRAEAE----RLGHEL 1659
Query: 543 QVEGLR-RRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALE 601
Q GL+ + E+ + L+ + + A+V+ +L++ G+ Q A +AL+ + +
Sbjct: 1660 QQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDL-GKFQ---VATDALKSREPQAK 1715
Query: 602 RQL 604
QL
Sbjct: 1716 PQL 1718
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 93.6 bits (231), Expect = 5e-19
Identities = 81/287 (28%), Positives = 130/287 (45%), Gaps = 18/287 (6%)
Query: 35 LDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLK 94
LDL S+ + +AL L T L L + ++GA + L +N L L L+
Sbjct: 699 LDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQ 758
Query: 95 GNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNN 154
N++ GA+ + L+QN+S++ L NS+G D L N L+ LDL++N
Sbjct: 759 KNSIGPMGAQRMADALKQNRSLKELMFSSNSIG--DGGAKALAEALKVNQGLESLDLQSN 816
Query: 155 QISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPG 214
IS G L AL N TL L LR N++ G +A+ + L +N TL LDL N +
Sbjct: 817 SISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHD 876
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQART--HVLSKEVQHLREEKSKQFLDL---METIDKQ 269
RA+ A+ +EN+ T H+ +Q + Q L L + ++D Q
Sbjct: 877 QGARAIAVAV----------RENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQ 926
Query: 270 REEMAKSSRASAARVGQLQEALNERHSIINALKAK-LQMTEAALALS 315
+ + AR ++ AL + + ++ A Q+ ALA++
Sbjct: 927 ENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVN 973
Score = 88.2 bits (217), Expect = 2e-17
Identities = 68/223 (30%), Positives = 107/223 (47%), Gaps = 8/223 (3%)
Query: 8 YSRLCRESGAEPQEAVLQQLHQLPRGR------LDLATQSLTVETCRALGKLLPRETLCT 61
Y R R + Q+ V++ L + G+ + LA ++ + +AL + L T
Sbjct: 638 YCRKLRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLT 697
Query: 62 ELVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLTL 121
L L + +GA L L N L L L+GN +R GA ++ + L N+++ L L
Sbjct: 698 SLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHL 757
Query: 122 EWNSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRW 181
+ NS+G L N +L+ L +N I GA+ LA ALK N L+ LDL+
Sbjct: 758 QKNSIGPM--GAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQS 815
Query: 182 NNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAM 224
N++ G ALM L +N+TL L L N+I + +A+ A+
Sbjct: 816 NSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHAL 858
Score = 87.0 bits (214), Expect = 5e-17
Identities = 67/212 (31%), Positives = 97/212 (45%), Gaps = 4/212 (1%)
Query: 13 RESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSE 72
R+ GA L L L L S+ + + L + EL+ S + +
Sbjct: 735 RDDGARSMAEALASNRTL--SMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGD 792
Query: 73 EGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDA 132
GA L L N L LDL+ N++ AG AL L N+++ SL+L NS+ +
Sbjct: 793 GGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISP--EG 850
Query: 133 FATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRAL 192
L AN L+ LDL N + +GA +A+A++ N TL L L+WN + +AL
Sbjct: 851 AQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQAL 910
Query: 193 MNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAM 224
L NR+L LDL N I D AV +A+
Sbjct: 911 GQALQLNRSLTSLDLQENAIGDDGACAVARAL 942
Score = 86.7 bits (213), Expect = 6e-17
Identities = 66/217 (30%), Positives = 105/217 (48%), Gaps = 28/217 (12%)
Query: 35 LDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLK 94
L L S++ E +A+ L + L L+ +L ++GA + + N L L L+
Sbjct: 839 LSLRENSISPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQ 898
Query: 95 GNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCG---------------- 138
N ++A A+ALG+ LQ N+S+ SL L+ N++G D A A
Sbjct: 899 WNFIQAGAAQALGQALQLNRSLTSLDLQENAIGD-DGACAVARALKVNTALTALYLQVAS 957
Query: 139 -----------GLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLL 187
LA N L+ LDLR N I GA+ LA ALK N++L++L+L+ N++G+
Sbjct: 958 IGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMD 1017
Query: 188 GGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAM 224
G + L N L ++L GN+I R + +A+
Sbjct: 1018 GAICIATALSGNHRLQHINLQGNHIGDSGARMISEAI 1054
Score = 81.6 bits (200), Expect = 2e-15
Identities = 51/165 (30%), Positives = 85/165 (51%), Gaps = 2/165 (1%)
Query: 35 LDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDLK 94
L L + +ALG+ L T L L + + ++GA + R L NT L L L+
Sbjct: 895 LHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQ 954
Query: 95 GNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRNN 154
++ A+GA+ LG+ L N++++ L L N++G L N +L+RL+L+ N
Sbjct: 955 VASIGASGAQVLGEALAVNRTLEILDLRGNAIGV--AGAKALANALKVNSSLRRLNLQEN 1012
Query: 155 QISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSN 199
+ GA +A AL GN LQ ++L+ N++G G R + + +N
Sbjct: 1013 SLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARMISEAIKTN 1057
Score = 72.4 bits (176), Expect = 1e-12
Identities = 89/325 (27%), Positives = 141/325 (43%), Gaps = 29/325 (8%)
Query: 61 TELVLSDCMLSEEGATLLLRGLCANTVLRFL-------DLKGNNLRAAGAEALGKLLQQN 113
TEL S E GA L G L +L + N + L LL Q
Sbjct: 577 TELARSVEEAMESGALARLTGPAHRAALAYLLQVSDACAQEANLSLSLSQGVLQSLLPQL 636
Query: 114 KSIQSLTLEWNSLGTWDDAFATFCGGLAANG--ALQRLDLRNNQISHKGAEELALALKGN 171
+ L L+ N + D G + + +Q++ L NQIS+KGA+ LA +L N
Sbjct: 637 LYCRKLRLDTNQ---FQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVN 693
Query: 172 TTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQD-R 230
+L LDLR N++G G +AL + L NRTL L L GN + D R++ +A+ ++
Sbjct: 694 RSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLS 753
Query: 231 LTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEA 290
+ Q+N + L++ +S + +LM + + + AK + A A +V Q E+
Sbjct: 754 MLHLQKNSIGPMGAQRMADALKQNRSLK--ELMFSSNSIGDGGAK-ALAEALKVNQGLES 810
Query: 291 LN-ERHSIINALKAKL------QMTEAALALSEQKAQDLG------ELLATAEQEQLSLS 337
L+ + +SI +A A L T +L+L E G L A + + L L+
Sbjct: 811 LDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLT 870
Query: 338 QRQAKELKLEQQEAAERESKLLRDL 362
+ A RE++ L L
Sbjct: 871 ANLLHDQGARAIAVAVRENRTLTSL 895
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 91.7 bits (226), Expect = 2e-18
Identities = 112/452 (24%), Positives = 208/452 (46%), Gaps = 64/452 (14%)
Query: 234 FQENQARTHVLSKEVQHLREEKSKQFLDLMETIDK-------QREEMAKSSRASAARVGQ 286
++ Q++ + + HL EE+ + D++ ++ K + SA +V Q
Sbjct: 761 YRIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQ 820
Query: 287 LQEA--LNERH----SIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQ 340
A L RH + +K LQ+T E L ++E L + ++Q
Sbjct: 821 RNCAAYLKLRHWQWWRVFTKVKPLLQVTRQE------------EELQAKDEELLKVKEKQ 868
Query: 341 AKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQ--EQLFQTRQEMT 398
K ++ E +E + +LL EKN+L + E E ++ +L +QE+
Sbjct: 869 TK-VEGELEEMERKHQQLLE------EKNILAEQLQAETELFAEAEEMRARLAAKKQELE 921
Query: 399 SMSAELKMRAIQAEER---LDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERV 455
+ +L+ R + EER L EK++ + ++D E ++ E E + L+ + + ++
Sbjct: 922 EILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE-QLDEEEGARQKLQLEKVTAEAKI 980
Query: 456 QRLEAARLSLEEELSR-VKAAALSERGQAE------EELIKAKSQARLEEQQR--LAHLE 506
+++E L LE++ S+ +K L E AE EE KAK+ A++ +Q ++ LE
Sbjct: 981 KKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE 1040
Query: 507 DKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRL----EELQQELSLKD 562
++L+ + R E + A + + Q ++++L Q++ L+ +L EELQ L+ D
Sbjct: 1041 ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGD 1100
Query: 563 QERVAEVSRVRV--ELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREAL----- 615
E + + + ++V ELQ Q LQ + +++A R KA +R L S+ EAL
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL----SEELEALKTELE 1156
Query: 616 --LDRESENASLREKLRLREAEIARIRDEEAQ 645
LD + LR K AE+ + +EE +
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETK 1188
Score = 85.1 bits (209), Expect = 2e-16
Identities = 98/431 (22%), Positives = 195/431 (45%), Gaps = 33/431 (7%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQL 287
QD QE + LS ++ L EEK+ + E ++ R+ + K A +++
Sbjct: 1318 QDTQELLQEETRQKLNLSSRIRQLEEEKNS-LQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 288 QEALNERHSIINALK-AKLQMTEAALALS---EQKAQDLGELLATAEQEQLSLSQRQAKE 343
++ +++ I +L+ AK ++ + A ALS E+KA +L T + Q L +
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV-D 1435
Query: 344 LKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAE 403
L ++Q A+ E K + E+ + +E +R + + + + S++
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA----EAEAREKETKALSLARA 1491
Query: 404 LKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARL 463
L+ A++A+E + + ++ R +ED S + +V LE+S++A++++V+ +
Sbjct: 1492 LE-EALEAKEEFERQNKQLRADMEDLMSSK-DDVGKNVHELEKSKRALEQQVEEMRTQLE 1549
Query: 464 SLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGAC 523
LE+EL + A L + E + K+Q + Q R E+K RLL +
Sbjct: 1550 ELEDELQATEDAKL----RLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK--------- 1596
Query: 524 LQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQE-RVAEVSRVRVELQEQNGR 582
Q +++ AE + Q L V ++ E+ LKD E ++ ++ R E+ +Q +
Sbjct: 1597 -QVRELEAELEDERKQRALAVASKKK------MEIDLKDLEAQIEAANKARDEVIKQLRK 1649
Query: 583 LQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDE 642
LQA++ + E+A A ++ + + + L E+E L+E+L E E
Sbjct: 1650 LQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQE 1709
Query: 643 EAQRASFLQNA 653
+ A + N+
Sbjct: 1710 RDELADEITNS 1720
Score = 79.7 bits (195), Expect = 8e-15
Identities = 96/413 (23%), Positives = 183/413 (44%), Gaps = 25/413 (6%)
Query: 246 KEVQHLREEKSKQFLDLMETID---KQREEMAKSSRASAARVGQLQEALNERHSIINALK 302
+E + ++ DLM + D K E+ KS RA +V +++ L E + A +
Sbjct: 1500 EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE 1559
Query: 303 -AKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRD 361
AKL++ A+ Q +DL + +E+ L +Q +EL+ E ++ ++ R
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDL-QTRDEQNEEKKRLLIKQVRELEAELEDERKQ-----RA 1613
Query: 362 LSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRR 421
L+ A++K + + + +LE + + + +++ + A++K + EE
Sbjct: 1614 LAVASKKKMEID--LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 422 CRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQR-LEAARLSLEEELSRV---KAAAL 477
QS E + L+ E E + L+E E A ER +R E R L +E++ K+A L
Sbjct: 1672 FAQSKESEKKLKSLEAEIL--QLQE-ELASSERARRHAEQERDELADEITNSASGKSALL 1728
Query: 478 SERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRV 537
E+ + E + + + + EEQ + L D+ R D ++ ++
Sbjct: 1729 DEKRRLEARIAQLEEELE-EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNAR 1787
Query: 538 SQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKA 597
QL Q + L+ +L+EL+ + K + ++ + +L+EQ + E AA L +
Sbjct: 1788 QQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRT 1847
Query: 598 AALERQLKVMASDHREAL--LDRESENASLREKLRLREAEIARIRDEEAQRAS 648
+++ + D R + E A+ R K R+ E A +EEA RA+
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEA---EEEATRAN 1897
Score = 78.2 bits (191), Expect = 2e-14
Identities = 110/499 (22%), Positives = 214/499 (42%), Gaps = 75/499 (15%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQ---REEMAKSSRASAARV 284
+DR+ A +K + +R ++ DL E + K+ R+E+ K+ R
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 285 GQLQEALNERHSIINALKAKLQMTEA------------------ALALSEQKAQDLGELL 326
LQ+ + E + I+ LK +L E AL + + + EL
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124
Query: 327 ATAEQEQLSLSQRQAKELKL-EQQEAAERESKLLRDLSAANEK-NLLLQNQVDEL----E 380
E E+ S ++ + ++ L E+ EA + E + D +AA ++ + +V EL E
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 381 RKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEE-RLDMEKRRCRQSLEDSE-SLRIKEVE 438
+ + + Q+ RQ + EL + QA+ + ++EK + ++ E + +K ++
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244
Query: 439 HMTRHLEESEKAMQERVQRLEAA-------RLSLEEELSRVK------------------ 473
+ E K + +VQ L A R+ L E+ S+++
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI 1304
Query: 474 -----AAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQ 528
AA+L + Q +EL++ +++ +L R+ LE++ L + ++E + A ++
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364
Query: 529 VVAEAQTRVSQLGLQVE---GLRRRLEELQQELSLKDQE----RVAEVSRVRVELQEQNG 581
V Q++++ +V+ G LEE +++L LKD E R+ E + +L++
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKL-LKDAEALSQRLEEKALAYDKLEKTKN 1423
Query: 582 RLQAEL----AAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIA 637
RLQ EL + R+ A+ LE++ K + L + +S +A E+ EAE
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQK----KFDQLLAEEKSISARYAEERDRAEAEAR 1479
Query: 638 RIRDEEAQRASFLQNAVLA 656
+ A L+ A+ A
Sbjct: 1480 EKETKALSLARALEEALEA 1498
Score = 67.4 bits (163), Expect = 4e-11
Identities = 95/466 (20%), Positives = 200/466 (42%), Gaps = 42/466 (9%)
Query: 212 IPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQH---LREEKSKQFLDLMETIDK 268
+ G + R ++ + H + L +E QA+ L ++ + R + KQ DL E ++
Sbjct: 1092 LQGALARGDDETL-HKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 269 QREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLAT 328
+ E+ + +AA+ QE +R + LK L E E + QD+ + AT
Sbjct: 1151 LKTELEDTLDTTAAQ----QELRTKREQEVAELKKAL---EEETKNHEAQIQDMRQRHAT 1203
Query: 329 AEQEQLSLSQRQAK----------------------ELKLEQQEAAERESKLLRDLSAAN 366
A E+LS QAK E+K+ QQ AE E K + L A
Sbjct: 1204 A-LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK-RKKLDAQV 1261
Query: 367 EKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQ-AEERLDMEKR-RCRQ 424
++ ++ D L + + +L ++++ E + + I+ A++ +E + + Q
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321
Query: 425 SLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAE 484
L E+ + + R LEE + ++QE+ + E AR +LE+++ +++ + + +
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381
Query: 485 EEL--IKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVS---Q 539
++L I++ +A+ + + L +L A A D+ + + +Q + + + Q
Sbjct: 1382 DDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQ 1441
Query: 540 LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAA 599
+ +E +++ ++L E E R E +E+ + + A E E
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 600 LERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQ 645
ERQ K + +D + + ++ ++ E + + A ++ + Q
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547
Score = 54.7 bits (130), Expect = 3e-07
Identities = 69/271 (25%), Positives = 116/271 (42%), Gaps = 35/271 (12%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
D R +E+A + +E++ + L E+ L+EE + +++R+E+A
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA-EQERDELA 1714
Query: 275 KSSRASA--------------ARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQ 320
SA AR+ QL+E L E S + L + + T L + A+
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKT--TLQVDTLNAE 1772
Query: 321 DLGELLATAEQEQLSLS-QRQAKELKLEQQE-AAERESKLLRDLSAANEKNLLLQNQVDE 378
E A + + +RQ KELK + QE +SK +SA K L+ Q+++
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQ 1832
Query: 379 LERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVE 438
E K R +L + ++ +LK +Q E+ E+R Q E E + ++
Sbjct: 1833 -EAKERAAANKLVRRTEK------KLKEIFMQVED----ERRHADQYKEQMEKANAR-MK 1880
Query: 439 HMTRHLEESEKAMQERVQRLEAARLSLEEEL 469
+ R LEE+E E R A+R L+ EL
Sbjct: 1881 QLKRQLEEAE----EEATRANASRRKLQREL 1907
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/354 (22%), Positives = 146/354 (41%), Gaps = 73/354 (20%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREE--------------KSKQFLDL------METID 267
+D T ++N+ + +L K+V+ L E K K +DL +E +
Sbjct: 1578 RDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAAN 1637
Query: 268 KQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLA 327
K R+E+ K R A++ Q L E + + + A+ + +E L E + L E LA
Sbjct: 1638 KARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELA 1697
Query: 328 T-------AEQEQLSLSQR-----QAKELKLEQQEAAERESKLLRDLSAANEKNLLLQN- 374
+ AEQE+ L+ K L+++ E L + + N+ L N
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 375 -------QVDELERKFRCQQ---EQLFQTRQEMTSMSAELKMR----------------- 407
QVD L + ++ ++ RQ++ + ELK +
Sbjct: 1758 RFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATIS 1817
Query: 408 AIQA-----EERLDME--KRRCRQSLEDSESLRIKE----VEHMTRHLEESEKAMQERVQ 456
A++A EE+L+ E +R L ++KE VE RH ++ ++ M++
Sbjct: 1818 ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANA 1877
Query: 457 RLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLR 510
R++ + LEE A S R + + EL A ++A + ++ L+++LR
Sbjct: 1878 RMKQLKRQLEEAEEEATRANASRR-KLQRELDDA-TEANEGLSREVSTLKNRLR 1929
Score = 46.6 bits (109), Expect = 7e-05
Identities = 43/179 (24%), Positives = 82/179 (45%), Gaps = 14/179 (7%)
Query: 484 EEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQ 543
+EE ++AK + L+ +++ +E +L + + + L++K ++AE ++L +
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQL----LEEKNILAEQLQAETELFAE 905
Query: 544 VEGLRRRLEELQQELS--LKDQE-RVAEVSRVRVELQEQNGRLQA-------ELAAQEAL 593
E +R RL +QEL L D E RV E LQ + ++QA +L +E
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 594 REKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQN 652
R+K + + E +L E +N+ ++ +L E IA + A+ +N
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Score = 32.3 bits (72), Expect = 1.5
Identities = 35/136 (25%), Positives = 60/136 (44%), Gaps = 7/136 (5%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
+ A+E +G +++L + +A + L + + +E Q D D+ +E+M K+
Sbjct: 1816 ISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKA 1875
Query: 277 SRASAARVGQLQEALNERHSIINALKAKLQ-----MTEAALALSEQKAQDLGELLATAEQ 331
+ QL+EA E + NA + KLQ TEA LS ++ L L
Sbjct: 1876 NARMKQLKRQLEEA-EEEATRANASRRKLQRELDDATEANEGLS-REVSTLKNRLRRGGP 1933
Query: 332 EQLSLSQRQAKELKLE 347
S S+ ++L LE
Sbjct: 1934 ISFSSSRSGRRQLHLE 1949
>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
Length = 488
Score = 91.3 bits (225), Expect = 3e-18
Identities = 67/218 (30%), Positives = 100/218 (45%), Gaps = 6/218 (2%)
Query: 8 YSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSD 67
Y C+ G P ++ + + ++L L +A+ L T+L L D
Sbjct: 86 YLEACKLMGVVPVSYFIRNMEE---SYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELED 142
Query: 68 CMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKS-IQSLTLEWNSL 126
+ EEG L+ L N L+ +++ N+L GA + ++N S I SL L N
Sbjct: 143 NCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDF 202
Query: 127 GTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGL 186
+D+ A C L+ N +++LDL +NQ S G E L L N L LDL WNN
Sbjct: 203 K--EDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHT 260
Query: 187 LGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAM 224
G AL N L N TL +LDL+ N +V A+ + +
Sbjct: 261 RGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVL 298
Score = 75.5 bits (184), Expect = 1e-13
Identities = 64/216 (29%), Positives = 94/216 (43%), Gaps = 9/216 (4%)
Query: 9 SRLCRESGAEPQEAVLQQLHQLPRG----RLDLATQSLTVETCRALGKLLPRETLCT-EL 63
++L E +E VL + L ++++ L +E R + R + L
Sbjct: 136 TKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSL 195
Query: 64 VLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLTLEW 123
LS E+ A LL + L N ++ LDL N G E LG++L N + SL L W
Sbjct: 196 ELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSW 255
Query: 124 NSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNN 183
N+ T C GL N L +LDL N ++ A L L+ N L LD+ N+
Sbjct: 256 NNFHT--RGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGND 313
Query: 184 VGLLGGRALMNCLPSNRTLWRLDLAGN--NIPGDVL 217
+G G + L SN +L L L N N+ G +L
Sbjct: 314 IGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
Score = 55.1 bits (131), Expect = 2e-07
Identities = 48/151 (31%), Positives = 71/151 (47%), Gaps = 2/151 (1%)
Query: 34 RLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDL 93
+LDL+ + LG++L T L LS GA L GL N L LDL
Sbjct: 222 KLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDL 281
Query: 94 KGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRN 153
N A ALG++L+ N+ + L + N +G ++ + GL +N +L+ L L
Sbjct: 282 SMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIG--NEGASKISKGLESNESLRVLKLFL 339
Query: 154 NQISHKGAEELALALKGNTTLQQLDLRWNNV 184
N I+ GA L LA+K N + +L +NV
Sbjct: 340 NPINMDGAILLILAIKRNPKSRMEELDISNV 370
Score = 33.1 bits (74), Expect = 0.85
Identities = 29/113 (25%), Positives = 50/113 (44%)
Query: 34 RLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDL 93
+LDL+ E ALG++L L + + EGA+ + +GL +N LR L L
Sbjct: 278 KLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKL 337
Query: 94 KGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGAL 146
N + GA L +++N + L+ +++ + T G A + L
Sbjct: 338 FLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQL 390
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 90.1 bits (222), Expect = 6e-18
Identities = 111/491 (22%), Positives = 209/491 (42%), Gaps = 78/491 (15%)
Query: 221 EQAMGHSQDRLTTFQE----NQARTHVLSKEVQHLREEKSKQFL------DLMETIDKQR 270
E+ M ++ T +E ++AR L +++ L +EK+ L D + +++
Sbjct: 846 EKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERC 905
Query: 271 EEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAE 330
+++ K+ A+V ++ E L + + L AK + E + ++ DL LA E
Sbjct: 906 DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVE 965
Query: 331 QEQ-------LSLSQRQA------KELKLEQQEAAERESKLLRDLSAANEK-------NL 370
+E+ +L++ A +L E++ E + L DL A +K +
Sbjct: 966 KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKV 1025
Query: 371 LLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAI----------QAEERL---DM 417
L+ QVD+LE +++ + + +LK+ Q +ERL D
Sbjct: 1026 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDF 1085
Query: 418 EKRRCRQSLEDSESL------RIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSR 471
E +ED ++L ++KE++ LEE +A + ++E R L EL
Sbjct: 1086 ELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1145
Query: 472 VKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVA 531
+ + L E G A I+ + E Q+ LE+ A + EA A L++K +
Sbjct: 1146 I-SERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE-----ATLQHEATAAALRKKHADS 1199
Query: 532 EAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQE 591
V++LG Q++ L+R ++L++E S ++EL + ++ + A+
Sbjct: 1200 -----VAELGEQIDNLQRVKQKLEKEKS-----------EFKLELDDVTSNMEQIIKAKA 1243
Query: 592 ALREKAAALERQLKVMASDHREALLDRE---SENASLREKLRLREAEIARIRDEEAQRAS 648
L + LE Q+ ++HR + + ++ S R KL+ E++R DE+ S
Sbjct: 1244 NLEKMCRTLEDQM----NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALIS 1299
Query: 649 FLQNAVLAYVQ 659
L L Y Q
Sbjct: 1300 QLTRGKLTYTQ 1310
Score = 71.2 bits (173), Expect = 3e-12
Identities = 92/449 (20%), Positives = 203/449 (45%), Gaps = 76/449 (16%)
Query: 235 QENQARTH---VLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
+E +A+ VLSK + + ++K D ++ + EE+ ++ + A R+ + +EA+
Sbjct: 1349 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQ----RTEELEEAKKKLAQRLQEAEEAV 1404
Query: 292 ---NERHSIINALKAKLQ-----------MTEAALALSEQKAQDLGELLATAEQE----- 332
N + S + K +LQ + AA A ++K ++ ++LA +Q+
Sbjct: 1405 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQ 1464
Query: 333 -QLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQE--- 388
+L SQ++A+ L E + + L L +N LQ ++ +L + +
Sbjct: 1465 SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIH 1524
Query: 389 QLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESE 448
+L + R+++ + EL+ +AE L+ E+ + ++ + ++ + + EE E
Sbjct: 1525 ELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME 1584
Query: 449 KAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQ-RLAHLED 507
+A + ++ +++ + SL+ E R + E +K K + L E + +L+H
Sbjct: 1585 QAKRNHLRVVDSLQTSLDAET----------RSRNEALRVKKKMEGDLNEMEIQLSHAN- 1633
Query: 508 KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVA 567
R+ A+A QKQV + Q+ + +Q++ R ++L++ +++
Sbjct: 1634 --RMAAEA----------QKQVKS-LQSLLKDTQIQLDDAVRANDDLKENIAI------- 1673
Query: 568 EVSRVRVELQEQNGRLQAELAAQEAL---REKAAALERQLKVMASDHREALLDRESENAS 624
++ +N LQAEL A+ E++ L Q + S+ + L S+N S
Sbjct: 1674 --------VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL---HSQNTS 1722
Query: 625 LREKLRLREAEIARIRDEEAQRASFLQNA 653
L + + +A++++++ E + +NA
Sbjct: 1723 LINQKKKMDADLSQLQTEVEEAVQECRNA 1751
Score = 64.3 bits (155), Expect = 3e-10
Identities = 77/368 (20%), Positives = 169/368 (45%), Gaps = 45/368 (12%)
Query: 261 DLMETIDKQREEMAKSSRASAARVGQLQEALN-ERHSIINALKAKLQMTEAALALSEQKA 319
++ + ++ EEM ++ R V LQ +L+ E S AL+ K +M E L E +
Sbjct: 1571 EIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKM-EGDLNEMEIQL 1629
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDEL 379
+ A A+++ SL Q K+ +++ +A L +++ +N LLQ +++EL
Sbjct: 1630 SHANRMAAEAQKQVKSL-QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEEL 1688
Query: 380 -------ERKFRCQQEQLFQT--------RQEMTSMSAELKMRAIQAEERLDMEK--RRC 422
ER + +++L +T Q + ++ + KM A ++ + ++E+ + C
Sbjct: 1689 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQEC 1748
Query: 423 RQSLEDSESL---------RIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELS--- 470
R + E ++ +K+ + + HLE +K M++ ++ L+ RL E+++
Sbjct: 1749 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ-HRLDEAEQIALKG 1807
Query: 471 -RVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQV 529
+ + L R + E ++A+ + E + + E +++ L +E ++
Sbjct: 1808 GKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEE-------DRKN 1860
Query: 530 VAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAA 589
+ Q V +L L+V+ +R+ EE +++ + +++ +V+ EL E R +
Sbjct: 1861 LLRLQDLVDKLQLKVKAYKRQAEEAEEQAN----TNLSKFRKVQHELDEAEERADIAESQ 1916
Query: 590 QEALREKA 597
LR K+
Sbjct: 1917 VNKLRAKS 1924
Score = 62.4 bits (150), Expect = 1e-09
Identities = 97/464 (20%), Positives = 203/464 (43%), Gaps = 45/464 (9%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVG-- 285
+D++ T + + + +++ E++ K +DL E ++ E K ++ S +
Sbjct: 1014 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDL-ERAKRKLEGDLKLTQESIMDLEND 1072
Query: 286 --QLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKE 343
QL E L ++ +NAL A+++ +A + ++K ++L + E+E + +AK
Sbjct: 1073 KQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKV 1132
Query: 344 LKLEQQEAAERE--SKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMS 401
KL + E E S+ L + A + + + + +K R E+ + E T+ +
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEA-TLQHEATAAA 1191
Query: 402 AELKMRAIQAE--ERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKA--------- 450
K AE E++D +R +Q LE +S E++ +T ++E+ KA
Sbjct: 1192 LRKKHADSVAELGEQID-NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCR 1250
Query: 451 -----MQERVQRLEAARLSLEEELSRVKAAALSERGQ------AEEELIKAKSQARLEEQ 499
M E + E + S+ +L+ +A +E G+ +E LI ++ +L
Sbjct: 1251 TLEDQMNEHRSKAEETQRSV-NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT 1309
Query: 500 QRLAHLEDKL-------RLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLE 552
Q+L L+ +L LA A A+ C ++ E ++L + +
Sbjct: 1310 QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1369
Query: 553 ELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHR 612
+ + + +R E+ + +L + RLQ A EA+ K ++LE+ + ++
Sbjct: 1370 QWRTKYETDAIQRTEELEEAKKKLAQ---RLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426
Query: 613 EALLDRESEN---ASLREKLRLREAEIARIRDEEAQRASFLQNA 653
+ ++D E N A+L +K R + +A + + + S L+++
Sbjct: 1427 DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESS 1470
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 89.0 bits (219), Expect = 1e-17
Identities = 79/418 (18%), Positives = 196/418 (46%), Gaps = 14/418 (3%)
Query: 204 RLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLM 263
+L+ A +P L+A +G ++ + Q + L + +EEK + + +
Sbjct: 311 KLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI 370
Query: 264 ETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLG 323
+ +++ +E + R ++ + +E + + ++ + K++ E + E+K +
Sbjct: 371 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE 430
Query: 324 ELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLL---QNQVDELE 380
E++ E++ L ++ ++ K+ +QE +E + +R+ E+ + + ++ E E
Sbjct: 431 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 490
Query: 381 RKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLED-SESLRIKEVEH 439
K R Q+E++++ +++ + Q +E + ++ + R+ E + +I E E
Sbjct: 491 EKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE 550
Query: 440 MTRHLEESEKAMQERVQRLEAARLSLEEELSR--VKAAALSERGQAEEELIKAKSQARLE 497
R EE +E++ E EE++ R K E+ + +EE I+ + + E
Sbjct: 551 KIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQE 610
Query: 498 EQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQE 557
+++++ E+K+ + E + +Q++ + E + ++ + Q E +R + EE+ QE
Sbjct: 611 QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE---QEEKIREQ-EEMMQE 666
Query: 558 LSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREAL 615
K E+ ++ ++QEQ +++ + +E + E+ L +Q + M +H+E L
Sbjct: 667 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQ---EEKMWEQEVRLRQQEEKM-QEHQEHL 720
Score = 83.6 bits (205), Expect = 6e-16
Identities = 100/456 (21%), Positives = 207/456 (45%), Gaps = 38/456 (8%)
Query: 219 AVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSR 278
AV+Q G ++D ++ ++ L + + + +K K +E + K+R+ ++
Sbjct: 213 AVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADR-YIEELTKERDALSLELY 271
Query: 279 ASAARVGQLQEA---LNERHSIINALKAKLQMT---------EAALALSEQKAQDLGELL 326
+ +L+E L E+ ++ + K+++Q+ A L L +Q+ Q + L
Sbjct: 272 RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 331
Query: 327 ATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQ---VDELERKF 383
Q + Q Q +E +L + ++E K+ R E +Q Q + E E K
Sbjct: 332 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKI 391
Query: 384 RCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRH 443
R Q+E++ RQE E KMR + EK R ++ + + +I+E+E H
Sbjct: 392 REQEEKM--RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM-H 448
Query: 444 LEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLA 503
+E + +E+ Q E R + + K E+ + +EE I+ + + +++++
Sbjct: 449 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKI- 507
Query: 504 HLEDKLRLLAQARDEAQGACLQQKQVVAEAQT---RVSQLGLQVEGLRRRLEEL-QQELS 559
H ++K+R + + + Q +Q++ + E + + ++ Q E +R++ E++ +QE
Sbjct: 508 HEQEKIR--EEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEK 565
Query: 560 LKDQERVAEVSRVRVELQEQNGRLQAELAAQ--EALREKAAALERQLKVMAS------DH 611
+ DQE +V QE+ R Q E + E +RE+ + Q + M +
Sbjct: 566 MHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQ 625
Query: 612 REALLDRESENASLREKLRLREAEI----ARIRDEE 643
E + ++E + EK+R +E +I +IR++E
Sbjct: 626 EEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQE 661
Score = 76.3 bits (186), Expect = 9e-14
Identities = 71/376 (18%), Positives = 175/376 (46%), Gaps = 47/376 (12%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
+R E+ M ++ + +E R +E+ +EEK ++ ++M +++ E+ +
Sbjct: 391 IREQEEKMRRQEEMMWEKEEKMRR----QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 446
Query: 277 SRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSL 336
++ + +E E I + K Q EA + E+K ++ E + E++
Sbjct: 447 MHEQE-KIREQEEKRQEEEKIRE--QEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQ 503
Query: 337 SQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQ--VDELERKFRCQQEQLFQTR 394
++ ++ K+ ++E + + ++ R E+ + + + + E E K R Q+E++++
Sbjct: 504 EEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQE 563
Query: 395 QEMTSMSAELKMRAIQAEERLDMEKRRCRQSLED--SESLRIKEVEHMTRHLEESEKAMQ 452
++M +++ + EE++ ++ + R+ E + +I+E E MT+ EE +
Sbjct: 564 EKMHDQEEKIR----EQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQE 619
Query: 453 ERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL 512
E++ E E+ Q +EE ++ + + E+++++ E+K+R
Sbjct: 620 EKMCEQE-------------------EKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ 660
Query: 513 AQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEEL-QQELSLKDQERVAEVSR 571
+ E + +Q++ + E + ++ + Q E +RR+ E++ +QE+ L+ QE
Sbjct: 661 EEMMQEQEEKMWEQEEKMCEQEEKMQE---QEEKMRRQEEKMWEQEVRLRQQEE------ 711
Query: 572 VRVELQEQNGRLQAEL 587
++QE L+A +
Sbjct: 712 ---KMQEHQEHLEAAI 724
Score = 53.5 bits (127), Expect = 6e-07
Identities = 74/314 (23%), Positives = 134/314 (42%), Gaps = 38/314 (12%)
Query: 347 EQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKM 406
EQ+ + + + L R+L A +L Q EL+ Q + Q E + + L
Sbjct: 171 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH- 229
Query: 407 RAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLE 466
+ + LE + S + + R++EE K + LE R ++
Sbjct: 230 -----------DSWKFAGELEQALSAVATQKKKADRYIEELTK--ERDALSLELYRNTIT 276
Query: 467 EELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACL-- 524
+E + K A L E+ Q E KS+ +L ++ LE LL Q + +A+ L
Sbjct: 277 DEELKEKNAKLQEKLQLVES---EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 333
Query: 525 QQKQVVAEAQTRVSQ------LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQE 578
+ + V A+ Q +V + L Q E R EE QE K QE+ ++ +++E
Sbjct: 334 ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIRE 393
Query: 579 QNGRLQAELAAQEALREKAAALERQLKVM------ASDHREALLDRESENASLREKLRLR 632
Q +++ + +E + EK + RQ ++M E + ++E + L EK+ +
Sbjct: 394 QEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 450
Query: 633 EAEIARIRDEEAQR 646
E +IR++E +R
Sbjct: 451 E----KIREQEEKR 460
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 88.6 bits (218), Expect = 2e-17
Identities = 82/444 (18%), Positives = 210/444 (47%), Gaps = 43/444 (9%)
Query: 204 RLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLM 263
+L+ A +P L+A +G ++ + Q + L + +EEK + + +
Sbjct: 250 KLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI 309
Query: 264 ETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLG 323
+ +++ +E + R ++ + +E + + ++ + K++ E + E+K + L
Sbjct: 310 QEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLE 369
Query: 324 ELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKF 383
E++ E++ L ++ ++ K+ +QE +E + +R+ E+ + Q E K
Sbjct: 370 EMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ----EEKI 425
Query: 384 RCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRH 443
R Q+E++ + ++M + I +E++ E++R Q + +I+E E + R
Sbjct: 426 REQEEKIREQEKKMWRQEEK-----IHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQ 480
Query: 444 LEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLA 503
E+ + QE++++ E EE++ +EE I+ + + +++++
Sbjct: 481 KEKMHE--QEKIRKQEEKVWRQEEKM------------HDQEEKIREQEEKMWRQEEKIR 526
Query: 504 HLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQ 563
E+K+R E + +Q++++ E + ++G Q E ++ + + +QE +++Q
Sbjct: 527 EQEEKIR-------EQEEKIREQEEMMQEQE---EKMGEQEEKMQEQEKMRRQEEKIREQ 576
Query: 564 ERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENA 623
E ++ + +++EQ ++ + +E +RE+ ++ Q + M + E + ++E +
Sbjct: 577 EE--KIREQKEKIREQEEKIWEQ---EEKIREQEEMMQEQEEKM-WEQEEKMCEQEEKMQ 630
Query: 624 SLREKLRLREAEI----ARIRDEE 643
EK+R +E ++ R+R +E
Sbjct: 631 EQEEKMRRQEEKMWEQEVRLRQQE 654
Score = 79.0 bits (193), Expect = 1e-14
Identities = 83/409 (20%), Positives = 196/409 (47%), Gaps = 26/409 (6%)
Query: 233 TFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALN 292
T +E + + L +++Q + EKS+ L++ E K++ E AK +
Sbjct: 215 TDEELKEKNAKLQEKLQLVESEKSEIQLNVKEL--KRKLERAKLLLPQQQLQAEADHLGK 272
Query: 293 ERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAA 352
E S+ L+A+++ E L++Q+ + + ++ + + Q Q ++++ ++++
Sbjct: 273 ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKI-QEQEEKIREQEEKIR 331
Query: 353 ERESKLLRDLSAANEKNLLLQNQVD---ELERKFRCQQEQLFQTRQEMTSMSAELKMRAI 409
E+E K+ R EK ++ Q + E E K R +E +++ +++ + E KM
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIREL--EEKMHE- 388
Query: 410 QAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEEL 469
Q + R EKR+ + + + E + +E + + EE + +E+++ E EE++
Sbjct: 389 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ--EEKIREQEEKIREQEKKMWRQEEKI 446
Query: 470 SRVKAAALSERGQAEEELIKAKSQARLEE----QQRLAHLEDKLRLLAQARDEAQGACLQ 525
+ E+ Q +EE+ + + + R +E Q+ H ++K+R + +
Sbjct: 447 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHD 506
Query: 526 QKQVVAEAQTRVSQLGLQVEGLRRRLEEL-QQELSLKDQERVAEVSRVRVELQEQNGRLQ 584
Q++ + E + ++ + Q E +R + E++ +QE +++QE + + E +E+ G +
Sbjct: 507 QEEKIREQEEKMWR---QEEKIREQEEKIREQEEKIREQEEMMQ------EQEEKMGEQE 557
Query: 585 AELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLRE 633
++ QE +R + + R+ + + +E + ++E + EK+R +E
Sbjct: 558 EKMQEQEKMRRQEEKI-REQEEKIREQKEKIREQEEKIWEQEEKIREQE 605
Score = 74.3 bits (181), Expect = 3e-13
Identities = 70/372 (18%), Positives = 174/372 (46%), Gaps = 41/372 (11%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
+R E+ M ++++ +E + ++ + EK ++ +L E + +Q + +
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQE 396
Query: 277 SRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSL 336
+ + QE E+ +AK+ E + E+K ++ + + E++
Sbjct: 397 EKRQEEEKIREQEKRQEQ-------EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ 449
Query: 337 SQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQE 396
+ + +E + EQ+E +E K+ ++ + Q + + K R Q+E++++ ++
Sbjct: 450 EKIREEEKRQEQEEMWRQEEKI------REQEEIWRQKEKMHEQEKIRKQEEKVWRQEEK 503
Query: 397 MTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQ 456
M +++ + EE++ ++ + R+ E +I+E E R E E+ MQE+ +
Sbjct: 504 MHDQEEKIR----EQEEKMWRQEEKIREQEE-----KIREQEEKIR---EQEEMMQEQEE 551
Query: 457 RLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQAR 516
++ ++E+ K E+ + +EE I+ + + E+++++ E+K+R +
Sbjct: 552 KMGEQEEKMQEQ---EKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMM 608
Query: 517 DEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEEL-QQELSLKDQERVAEVSRVRVE 575
E + +Q++ + E + ++ + Q E +RR+ E++ +QE+ L+ QE +
Sbjct: 609 QEQEEKMWEQEEKMCEQEEKMQE---QEEKMRRQEEKMWEQEVRLRQQEE---------K 656
Query: 576 LQEQNGRLQAEL 587
+QE L+A +
Sbjct: 657 MQEHQEHLEAAI 668
Score = 53.5 bits (127), Expect = 6e-07
Identities = 74/314 (23%), Positives = 134/314 (42%), Gaps = 38/314 (12%)
Query: 347 EQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKM 406
EQ+ + + + L R+L A +L Q EL+ Q + Q E + + L
Sbjct: 110 EQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH- 168
Query: 407 RAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLE 466
+ + LE + S + + R++EE K + LE R ++
Sbjct: 169 -----------DSWKFAGELEQALSAVATQKKKADRYIEELTK--ERDALSLELYRNTIT 215
Query: 467 EELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACL-- 524
+E + K A L E+ Q E KS+ +L ++ LE LL Q + +A+ L
Sbjct: 216 DEELKEKNAKLQEKLQLVES---EKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGK 272
Query: 525 QQKQVVAEAQTRVSQ------LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQE 578
+ + V A+ Q +V + L Q E R EE QE K QE+ ++ +++E
Sbjct: 273 ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIRE 332
Query: 579 QNGRLQAELAAQEALREKAAALERQLKVMASDH------REALLDRESENASLREKLRLR 632
Q +++ + +E + EK + RQ ++M E + ++E + L EK+ +
Sbjct: 333 QEEKMRRQ---EEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ 389
Query: 633 EAEIARIRDEEAQR 646
E +IR++E +R
Sbjct: 390 E----KIREQEEKR 399
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 88.6 bits (218), Expect = 2e-17
Identities = 101/375 (26%), Positives = 182/375 (48%), Gaps = 53/375 (14%)
Query: 300 ALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLL 359
AL+A+L+ ALA +E K Q+L E + QE+ L A +L+ EQ A+ E +
Sbjct: 900 ALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDL----ALQLQAEQDNLADAEERC- 954
Query: 360 RDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEK 419
+LL++++V +LE K + E+L ++ ++A+L R + E+
Sbjct: 955 ---------HLLIKSKV-QLEGKVKELSERL----EDEEEVNADLAARRRKLEDE----- 995
Query: 420 RRCRQSLEDSESLRI---------KEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELS 470
C + +D + L++ + E+ ++L E A+ E V RL + +L+E
Sbjct: 996 --CTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQ 1053
Query: 471 RVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLE------DKLRL-LAQARDEAQGAC 523
+ AL + QAEE+ + A ++A+L +Q++ LE KLR+ +A+ + +G
Sbjct: 1054 Q----ALGDL-QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDL 1108
Query: 524 LQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQ-ELSLKDQERV-AEVSRVRVELQEQNG 581
++ VA+A QL E L+++ EL Q L ++D++ + A++ + ELQ +
Sbjct: 1109 KLTQESVADAAQDKQQLE---EKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAE 1165
Query: 582 RLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRD 641
L+ EL A+ A R + + + E L + +A RE R REAE+ R+R
Sbjct: 1166 ELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLR- 1224
Query: 642 EEAQRASFLQNAVLA 656
E + A+ A +A
Sbjct: 1225 RELEEAALRHEATVA 1239
Score = 82.8 bits (203), Expect = 9e-16
Identities = 108/476 (22%), Positives = 207/476 (43%), Gaps = 54/476 (11%)
Query: 222 QAMGHSQDRLTTFQENQARTH-----VLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
QA+ H D L E +A +LSK + + +SK D ++ + EE+ ++
Sbjct: 1383 QALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQ----RTEELEEA 1438
Query: 277 SRASAARVGQLQE---ALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQE- 332
+ A R+ + +E A N + S + K +LQ + L ++A L ++
Sbjct: 1439 KKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHL 1498
Query: 333 QLSLSQRQAKELKLEQQ-EAAERESK---------------LLRDLSAANEKNLLLQNQV 376
+ +L +R+ +E +++++ EAA+RES+ L L +N LQ ++
Sbjct: 1499 ERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEI 1558
Query: 377 DELERKFRCQQ---EQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRC-RQSLEDSE-- 430
+L + ++L +T++ + +E++ +AE L++E+ + R LE S+
Sbjct: 1559 SDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVK 1618
Query: 431 ---SLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEEL 487
++ E + +L + + E +Q A E R+K + E +L
Sbjct: 1619 AEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQL 1678
Query: 488 IKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGL 547
A QA E Q ++ +L+ RDE Q + + + R S L ++E L
Sbjct: 1679 GHATRQAT-EAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEEL 1737
Query: 548 RRRLEELQQELSLKDQERVAEVSRVRV------ELQEQNGRLQAELA-----AQEALREK 596
R LE+ ++ L +QE + R+ + L Q +L+A+LA +EA +E+
Sbjct: 1738 RAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQER 1797
Query: 597 AAALERQLKVM--ASDHREALLDRESENASLREKLRLREAEIARI--RDEEAQRAS 648
A E+ K + A+ E L + +A L + E + + R EEA++A+
Sbjct: 1798 REAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAA 1853
Score = 70.9 bits (172), Expect = 4e-12
Identities = 110/446 (24%), Positives = 185/446 (41%), Gaps = 77/446 (17%)
Query: 244 LSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKA 303
L +E ++L+EE S D + K +E+ K+ +A ++Q AL E + +
Sbjct: 1547 LKRENKNLQEEIS-DLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEET 1605
Query: 304 KLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLS 363
K + L LS+ KA+ + LA ++E +L + + ++ Q + + E++ +
Sbjct: 1606 KTLRIQ--LELSQVKAE-VDRKLAEKDEECANLRRNHQRAVE-SLQASLDAETRARNEAL 1661
Query: 364 AANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAI--QAEERLDMEKRR 421
+K ++ +++LE + Q + + M A+LK E+RL E
Sbjct: 1662 RLKKK---MEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHE 1718
Query: 422 CRQSLEDSESLRIKEVEHMTRHLEESEK----AMQERVQRLEAARL-------------S 464
Q+LE SL E+E + LE+ E+ A QE ++ E L
Sbjct: 1719 QAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKK 1778
Query: 465 LEEELSRVKAA---ALSERGQAEEELIKAKSQARL------EEQQRLAHLEDKLRLLAQA 515
LE +L+++ A ER +AEE+ KA + A + +EQ AHLE + L Q
Sbjct: 1779 LEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQT 1838
Query: 516 -------RDEAQGACLQ--QKQV---------------------------VAEAQTRVSQ 539
+EA+ A L+ +KQV V + + RV +
Sbjct: 1839 VRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKE 1898
Query: 540 LGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQ-NGRLQAELAAQEAL---RE 595
L Q E R+ L + Q+L K Q +V R E ++Q N L AQ L E
Sbjct: 1899 LAYQAEEDRKNLARM-QDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEE 1957
Query: 596 KAAALERQLKVMASDHREALLDRESE 621
+A E Q + + R+AL + E
Sbjct: 1958 RADMAETQANKLRARTRDALGPKHKE 1983
Score = 70.1 bits (170), Expect = 6e-12
Identities = 125/534 (23%), Positives = 208/534 (38%), Gaps = 115/534 (21%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQL 287
QD L +E R H+L K L E K K+ + +E ++ ++A R +L
Sbjct: 944 QDNLADAEE---RCHLLIKSKVQL-EGKVKELSERLEDEEEVNADLAARRRKLEDECTEL 999
Query: 288 QEALNE-RHSIINALKAKL-------QMTEAALALSEQKAQDLGELLATAEQEQLSLSQR 339
++ +++ + ++ A K K +TE AL E A+ E A E Q +L
Sbjct: 1000 KKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDL 1059
Query: 340 QAKE----------LKLEQQE-----AAERESKLLRDLSAANEK-----NLLLQNQVD-- 377
QA+E L+LEQQ + E+E KL D A K L ++ D
Sbjct: 1060 QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAA 1119
Query: 378 ----ELERKFRCQQEQLFQTR----------QEMTSMSAELKMRAIQAEERLDMEKRRCR 423
+LE K + + +L Q +M EL+ RA + EE L+ E R R
Sbjct: 1120 QDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAE-RAAR 1178
Query: 424 QSLEDSESLRIKEVEHMTRHLEES-------EKAMQERVQRLEAARLSLEEELSRVKAA- 475
+E + +E+E ++ LEE+ + ++R L R LEE R +A
Sbjct: 1179 ARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAALRHEATV 1238
Query: 476 ALSERGQAE----------------EELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEA 519
A R QAE ++L K KS+ R+E A++E L +A+ A
Sbjct: 1239 AALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVET----LTRAKASA 1294
Query: 520 QGACLQQKQVVAEAQTRVSQLG------------LQVEG--------------------- 546
+ C + ++EA+ +V +L LQ E
Sbjct: 1295 EKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGK 1354
Query: 547 --LRRRLEELQQELSLKDQERVA---EVSRVRVELQEQNGRLQAELAAQEALREKAAALE 601
+ LEEL+++L + + + A V +R + + + E AQ L+ +
Sbjct: 1355 ALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKAN 1414
Query: 602 RQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFLQNAVL 655
++ S + + R E ++KL LR E + + S L+ A L
Sbjct: 1415 AEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKL 1468
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 88.2 bits (217), Expect = 2e-17
Identities = 95/449 (21%), Positives = 204/449 (45%), Gaps = 51/449 (11%)
Query: 219 AVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSR 278
AV+Q G ++D ++ ++ L + + + +K K +E + K+R+ ++
Sbjct: 140 AVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADR-YIEELTKERDALSLELY 198
Query: 279 ASAARVGQLQEA---LNERHSIINALKAKLQMT---------EAALALSEQKAQDLGELL 326
+ +L+E L E+ ++ + K+++Q+ A L L +Q+ Q + L
Sbjct: 199 RNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHL 258
Query: 327 ATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQ 386
Q + Q Q +E +L + ++E K+ R E+ + ++ E E K R Q
Sbjct: 259 GKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER----EEKIQEQEEKIREQ 314
Query: 387 QEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEE 446
+E++ RQE E KMR +E + EK + LE+ + K E + EE
Sbjct: 315 EEKM--RRQEEMMWEKEEKMRR---QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE 369
Query: 447 SEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLE 506
+ QE+ Q EA EE++ + +EE I+ + + E+++++ E
Sbjct: 370 EKIREQEKRQEQEAKMWRQEEKI------------REQEEKIREQEEMMQEQEEKMGEQE 417
Query: 507 DKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV 566
+K+ + E + +Q++ + E + ++ + Q E +R + EE+ QE K E+
Sbjct: 418 EKMWEQEEEMQEQEEKMRRQEEKIREQEKKIRE---QEEKIREQ-EEMMQEQEEKMGEQE 473
Query: 567 AEVSRVRVELQEQNGRLQAELAAQEALREKAAALE------RQLKVMASDHREALLDRES 620
++ ++QEQ +++ + +E +RE+ + R+ + M + E + ++E
Sbjct: 474 GKMCEQEAKMQEQEEKMRRQ---EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEE 530
Query: 621 ENASLREKLRLREAEIAR----IRDEEAQ 645
+ EK++ +E ++ R +R++E +
Sbjct: 531 KMCEQEEKMQEQEEKMRRQEEKMREQEVR 559
Score = 84.3 bits (207), Expect = 3e-16
Identities = 73/336 (21%), Positives = 159/336 (47%), Gaps = 26/336 (7%)
Query: 235 QENQARTHVLSKEVQHLREEKSKQFLD--LMETIDKQREEMAKSSRASAARVGQLQEALN 292
Q+ QA L KE+Q + + Q + L +++Q+EE ++ + +E +
Sbjct: 249 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEE---KIQEREEKIQ 305
Query: 293 ERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAA 352
E+ I + K++ E + E+K + E++ E++ L ++ ++ K+ +QE
Sbjct: 306 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 365
Query: 353 ERESKLLRDLSAANEKNLLLQNQ---VDELERKFRCQQEQLFQTRQEMTSMSAELKMRAI 409
+E + +R+ E+ + Q + E E K R Q+E + QE E + +
Sbjct: 366 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM----QEQEEKMGEQEEKMW 421
Query: 410 QAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEEL 469
+ EE + ++ + R+ E +I+E E R EE + +E +Q E E ++
Sbjct: 422 EQEEEMQEQEEKMRRQEE-----KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKM 476
Query: 470 SRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQV 529
+A + Q +EE ++ + + E+++++ E+K+R + E + +Q++
Sbjct: 477 CEQEA-----KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 531
Query: 530 VAEAQTRVSQLGLQVEGLRRRLEEL-QQELSLKDQE 564
+ E + ++ + Q E +RR+ E++ +QE+ L+ QE
Sbjct: 532 MCEQEEKMQE---QEEKMRRQEEKMREQEVRLRQQE 564
Score = 73.6 bits (179), Expect = 6e-13
Identities = 83/377 (22%), Positives = 183/377 (48%), Gaps = 45/377 (11%)
Query: 295 HSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSL--SQRQAKELKLEQQEAA 352
HS + KA Q EA E + Q + L + Q++L SQ K+L+ E ++
Sbjct: 93 HSPEDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 152
Query: 353 ER-------ESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQ---TRQEMTSMSA 402
R +L + LSA + ++EL ++ +L++ T +E+ +A
Sbjct: 153 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 212
Query: 403 EL--KMRAIQAEE-RLDMEKRRCRQSLEDSESLRIK-----EVEHMTRHLEESEKAMQER 454
+L K++ +++E+ + + + ++ LE ++ L + E +H+ + L+ +Q +
Sbjct: 213 KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 272
Query: 455 VQRLEA-ARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLA 513
V+ E RL+ ++E E+ +EE I+ + + E+++++ E+K+R
Sbjct: 273 VEENELWNRLNQQQE----------EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQE 322
Query: 514 QARDEAQGACLQQKQVVAEAQTRVSQLGLQV---EGLRRRLEELQQELSLKDQERVAEVS 570
+ E + +Q++++ E + ++ +L ++ E +R + E+ Q+E +++QE+ E
Sbjct: 323 EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE-Q 381
Query: 571 RVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLR 630
++ QE+ R Q +E +RE+ ++ Q + M + E + ++E E EK+R
Sbjct: 382 EAKMWRQEEKIREQ-----EEKIREQEEMMQEQEEKM-GEQEEKMWEQEEEMQEQEEKMR 435
Query: 631 LREAEI----ARIRDEE 643
+E +I +IR++E
Sbjct: 436 RQEEKIREQEKKIREQE 452
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 88.2 bits (217), Expect = 2e-17
Identities = 79/434 (18%), Positives = 194/434 (44%), Gaps = 46/434 (10%)
Query: 227 SQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQ 286
S ++L ++ A + ++ +EK +L +DK +++ + + +
Sbjct: 444 SSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK 503
Query: 287 LQEALNERHSI----------INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSL 336
L+EA N+ + I L+A LQ ++ ++L E++ +DL + E E L
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 563
Query: 337 SQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQE 396
+Q Q K L Q++ + KL + + L +QV E + R Q+++
Sbjct: 564 NQLQEKNHTL-QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETS 622
Query: 397 MTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQ 456
+ ++++L + + +LD++ + + L +E+ + + + HL+ ++ A+Q++ Q
Sbjct: 623 VNELNSQLN-ESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQ 681
Query: 457 RLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL---- 512
L L++ ++++ E E +K + L +Q+ LE +++ L
Sbjct: 682 ELNKITTQLDQVTAKLQDK--QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739
Query: 513 ---AQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEV 569
++++A QQ+Q+ + + R ++L Q+ E+++E+ V
Sbjct: 740 LEVKASKEQALQDLQQQRQLNTDLELRATELSKQL--------EMEKEI----------V 781
Query: 570 SRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKL 629
S R++LQ+++ A E++++K E + +++ D + + ++ L ++
Sbjct: 782 SSTRLDLQKKS-------EALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRI 834
Query: 630 RLREAEIARIRDEE 643
+ E+ +++ E+
Sbjct: 835 QTTVTELQKVKMEK 848
Score = 87.8 bits (216), Expect = 3e-17
Identities = 104/455 (22%), Positives = 212/455 (46%), Gaps = 50/455 (10%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
D L V ++ +S+ F++ + +++ +E Q ME K+++E+
Sbjct: 860 DKLSKVSDSLKNSKSE---FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
Query: 275 KSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQ-DLGELLATAEQEQ 333
KS QL+ LN + + L+ E EQ+ Q ++ EL ++EQ++
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK----EEQQLQGNINELKQSSEQKK 972
Query: 334 LSLSQRQAKELKLEQQEAAERESKL-------LRDLSAANEKNLLLQNQVD-------EL 379
+ Q ELK+ + E E+KL ++L+A EK +LQN + +L
Sbjct: 973 KQIEALQG-ELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQL 1031
Query: 380 ERKFRCQQEQLFQTRQEMTSMSAELKM---------RAIQAEERLDMEKRRCRQSLEDSE 430
+ F ++ +L TRQ++ S+ +L + I + +L E + + +LE
Sbjct: 1032 QSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDS 1091
Query: 431 SLRIKEVEHMTRHLEE--SEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELI 488
+ + ++++ + L++ EK+++E+ E ++L+ E+ +K E + EEL
Sbjct: 1092 AKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA---EIEEIKCRQEKEITKLNEELK 1148
Query: 489 KAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLR 548
K LE + + +L+D +LL Q + E QG K V + + L QV +
Sbjct: 1149 SHK----LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQV---K 1201
Query: 549 RRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQ-EALREKAAALERQLKVM 607
+ EEL++E K+ + +E+ V +++ +A+L Q AL E ++++ +
Sbjct: 1202 KEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEEN-EAKLTMQITALNENLGTVKKEWQ-- 1258
Query: 608 ASDHREALLDRESENASLREKLRLREAEIARIRDE 642
+S R + L++++++ LR ++ + EA + +DE
Sbjct: 1259 SSQRRVSELEKQTDD--LRGEIAVLEATVQNNQDE 1291
Score = 75.1 bits (183), Expect = 2e-13
Identities = 96/460 (20%), Positives = 197/460 (42%), Gaps = 64/460 (13%)
Query: 246 KEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKL 305
K+++ L E+K+ Q + I + +E A+ +V +L E LN+ ++I LK +L
Sbjct: 155 KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTEL 214
Query: 306 QMTEAA--LALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERE---SKLLR 360
+A+ +++ + L+ E+ S++ E K Q + A E S+L
Sbjct: 215 LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRS 274
Query: 361 DLSAANEKNLL-------LQNQVDELERKFRCQQEQLFQTRQEMTSMSAE-----LKMRA 408
+L+ ++ + L++ V+EL +K + E L + Q+ T + + + +
Sbjct: 275 ELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKN 334
Query: 409 IQA---EERLDMEKRRCRQSLEDSESLRI------------------KEVEHMTRHLEES 447
IQA ++ LD ++ + R S ++ RI EVE +HL+
Sbjct: 335 IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAE 394
Query: 448 EKAMQERVQRLEAARLSLEEELSRVKA-------------AALSERGQAEEELIKAKSQA 494
K +Q++ + E L L+ E++++ + L E+ Q E + K Q
Sbjct: 395 FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQ 454
Query: 495 RLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEEL 554
+ Q +L+ LE++L+ E Q + KQ E Q ++ + LE++
Sbjct: 455 VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQV 514
Query: 555 QQELSLKDQ-----ERVAEVSRVRVELQEQN-----GRLQA---ELAAQEALREKAAALE 601
+++ KDQ E + + S+ + L E+ ++QA E A L+EK L+
Sbjct: 515 LRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 602 RQLKVMASDHREALLDRESENASLREKLRLREAEIARIRD 641
Q+ + + + +L ++++ ++A + +D
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQD 614
Score = 69.3 bits (168), Expect = 1e-11
Identities = 96/474 (20%), Positives = 206/474 (43%), Gaps = 55/474 (11%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLM---ETIDKQRE 271
+V + EQA+ Q + + + R LSK+++ +E S LDL E ++ ++
Sbjct: 741 EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
Query: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
++ K + E L ++Q T L + + + L L+T +
Sbjct: 801 KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV-K 859
Query: 332 EQLSLSQRQAKELKLEQQEAAERESKLLRDL-SAANEKNLLLQNQVD-------ELERKF 383
++LS K K E ++ ++ + DL E LQ Q++ EL++
Sbjct: 860 DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL 919
Query: 384 RCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQ------SLEDSESLRIKEV 437
++E Q + E+ SM +L IQA+ L ++ +Q L+ S + K++
Sbjct: 920 EKEKEASHQLKLELNSMQEQL----IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQI 975
Query: 438 EHMTRHLEESEKAMQERVQRLEAARLSLEEELS--RVKAAALSERGQAEEELIK------ 489
E + L+ + E +L+ +EL+ + K + L + +E K
Sbjct: 976 EALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 490 -AKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQL-------G 541
+ L +Q L +E+KL L + + Q +++ E +T + L
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
Query: 542 LQVEGLRRRLEELQQELSLKDQE------RVAEVSRVRVELQEQNGRLQAELAAQ--EAL 593
Q++ + L+++Q+E SLK++E ++AE+ ++ +++ +L EL + E++
Sbjct: 1096 QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESI 1155
Query: 594 RE-------KAAALERQLKVMA-SDHREALLDRESENAS-LREKLRLREAEIAR 638
+E K ++++L++ +D +A +++E N L+++++ E E+ +
Sbjct: 1156 KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKK 1209
Score = 68.6 bits (166), Expect = 2e-11
Identities = 90/441 (20%), Positives = 189/441 (42%), Gaps = 56/441 (12%)
Query: 227 SQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQ 286
S + T Q + H+ Q+ ++K ++ + I Q +++ + Q
Sbjct: 653 SAEAAKTAQRADLQNHL--DTAQNALQDKQQE----LNKITTQLDQVTAKLQDKQEHCSQ 706
Query: 287 LQEALNERHSIINALKAKLQMTEAAL-----------ALSEQKAQDLG---------ELL 326
L+ L E +L+ K + E + A EQ QDL EL
Sbjct: 707 LESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELR 766
Query: 327 ATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQ 386
AT +QL + + +L+ Q+ +E + + L+ E+ +L+ + L ++ + Q
Sbjct: 767 ATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQ 826
Query: 387 QEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEE 446
E+L Q + ++KM +++L S ++ ++ L+
Sbjct: 827 HEELNNRIQTTVTELQKVKME---------------KEALMTELSTVKDKLSKVSDSLKN 871
Query: 447 SEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKS-QARLEEQQRLAH- 504
S+ ++ Q+ +AA L LE+ +K + Q E L + K + LE+++ +H
Sbjct: 872 SKSEFEKENQKGKAAILDLEKTCKELKHQL---QVQMENTLKEQKELKKSLEKEKEASHQ 928
Query: 505 LEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQE 564
L+ +L + + +AQ Q ++ + Q +++L E ++++E LQ EL +
Sbjct: 929 LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI---- 984
Query: 565 RVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLD---RESE 621
V + + + +LQ+Q + ELAA+ +EK + L+ + ++ D RESE
Sbjct: 985 AVLQKTELENKLQQQLTQAAQELAAE---KEKISVLQNNYEKSQETFKQLQSDFYGRESE 1041
Query: 622 NASLREKLRLREAEIARIRDE 642
+ R+ L+ E +++ +++
Sbjct: 1042 LLATRQDLKSVEEKLSLAQED 1062
Score = 55.5 bits (132), Expect = 2e-07
Identities = 74/357 (20%), Positives = 153/357 (42%), Gaps = 39/357 (10%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
L Q + +++++ Q N ++ K++Q + + L + + E+++ +
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLA 1059
Query: 277 SRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSL 336
++ ++ R+ I N K ++ A L + A+ +L QE+
Sbjct: 1060 Q----------EDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL-----QERCKA 1104
Query: 337 SQRQAKELKLEQQEAAERESKL--LRDLSAANEKNLLLQNQVDELE-RKFRCQQE--QLF 391
Q KE L+++E +SKL + ++ EK + N+ EL+ K +E L
Sbjct: 1105 LQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE--ELKSHKLESIKEITNLK 1162
Query: 392 QTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAM 451
+Q + EL+ +A + ++ EKR +Q L+D KE E + + E E +
Sbjct: 1163 DAKQLLIQQKLELQGKADSLKAAVEQEKRN-QQILKDQVK---KEEEELKKEFIEKEAKL 1218
Query: 452 QERVQRLEAARLSLEEELSRV--KAAALSER-GQAEEELIKAKSQARLEEQQR------- 501
++ E EE +++ + AL+E G ++E SQ R+ E ++
Sbjct: 1219 HSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEW--QSSQRRVSELEKQTDDLRG 1276
Query: 502 -LAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQE 557
+A LE ++ R CL+ + + + QT+V +L +++ ++EL +E
Sbjct: 1277 EIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRE 1333
Score = 51.2 bits (121), Expect = 3e-06
Identities = 93/402 (23%), Positives = 177/402 (44%), Gaps = 74/402 (18%)
Query: 302 KAKLQMTEAALALSEQKAQDL----------GELLATAEQEQLSLSQRQAK--------- 342
++ L + + L Q+ QDL E L ++ L Q++AK
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 343 -ELK-LEQQ-EAAERES---KLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQE 396
EL+ LEQQ E A+ E+ K ++DL +K L ++ +++ K+ ++ Q+
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDL--FEQKAAQLATEIADIKSKYDEERSLREAAEQK 192
Query: 397 MTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEV------EHMTRHLEESEKA 450
+T ++ EL A ++ L E + R +ED L+ + V ++MT E +
Sbjct: 193 VTRLTEELNKEATVIQD-LKTELLQ-RPGIEDVAVLKKELVQVQTLMDNMTLERERESEK 250
Query: 451 MQERVQRLEAARLSLEEELSRVK---AAALSERGQAEEELIKAKSQAR------------ 495
+++ ++L++ S E +S+++ A E +EL K KS
Sbjct: 251 LKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310
Query: 496 -LEEQQRLAHLEDKLRLLAQARDEAQGA-------CLQQKQVVAEAQTRVSQLGLQVEGL 547
L+++Q LE+K + ++ Q C Q + ++ ++T + ++ +++
Sbjct: 311 LLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEK 370
Query: 548 RRRLEELQQELS---LKDQERVAEVSRVRV--ELQEQNG-RLQAELAAQEALREKAAALE 601
++L++ELS K Q AE +++ E +EQ+G +LQ+E+ L K E
Sbjct: 371 GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEI---NQLHSKLLETE 427
Query: 602 RQ-------LKVMASDHREALLDRESENASLREKLRLREAEI 636
RQ LK E L+D+E + A L+ KL E ++
Sbjct: 428 RQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQL 469
Score = 39.7 bits (91), Expect = 0.009
Identities = 44/196 (22%), Positives = 95/196 (48%), Gaps = 20/196 (10%)
Query: 465 LEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQR-----LAHLEDKLRLLAQARDEA 519
L +E+ ++A+ E+ +EE + + L++Q+ + +L+ L Q +EA
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEA 147
Query: 520 QGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQ 579
Q KQ+ + + +QL ++ ++ + +E E SL++ +V+R+ EL ++
Sbjct: 148 QTENFNIKQMKDLFEQKAAQLATEIADIKSKYDE---ERSLREAAE-QKVTRLTEELNKE 203
Query: 580 NGRLQ---AELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLR------ 630
+Q EL + + E A L+++L + + L+RE E+ L+++ +
Sbjct: 204 ATVIQDLKTELLQRPGI-EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQY 262
Query: 631 -LREAEIARIRDEEAQ 645
EA I+++R E A+
Sbjct: 263 ASSEATISQLRSELAK 278
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 87.4 bits (215), Expect = 4e-17
Identities = 91/408 (22%), Positives = 192/408 (47%), Gaps = 38/408 (9%)
Query: 244 LSKEVQHLREEKSKQFLDL------METIDKQREEMAKSSRASAARVGQLQEALNERHSI 297
L + Q L +EKS+ +++ MET+ K + + K RA ++ +++ E+ +
Sbjct: 1214 LQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRL 1273
Query: 298 INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESK 357
IN L A+ + ++ + L++ + + + +Q Q +ELK + +E + +S
Sbjct: 1274 INDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQ-QIEELKRQLEEEIKAKSA 1332
Query: 358 LLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDM 417
L L ++ LL+ Q +E + Q + + E+ + + AIQ E L+
Sbjct: 1333 LAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEE 1392
Query: 418 EKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAAL 477
K++ Q L+D+E ++ V LE++++ +Q V+ L ++ E + AAL
Sbjct: 1393 AKKKLAQRLQDAEE-HVEAVNAKCASLEKTKQRLQNEVE-----DLMIDVERTNAACAAL 1446
Query: 478 SERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRV 537
++ Q + I A+ + + EE H E L ++ E++ + ++ + +
Sbjct: 1447 DKK-QRNFDKILAEWKQKCEE----THAE-----LEASQKESRSLSTELFKIKNAYEESL 1496
Query: 538 SQLGLQVEGLRRRLEELQQELS-LKDQ-----ERVAEVSRVRVELQEQNGRLQAELAAQE 591
QL E L+R + LQQE+S L +Q +R+ E+ +++ +++++ LQA L E
Sbjct: 1497 DQL----ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAE 1552
Query: 592 ALRE----KAAALERQLKVMASDHREALLDRESE-NASLREKLRLREA 634
A E K ++ +L + S+ + +++ E + R +R+ E+
Sbjct: 1553 ASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVES 1600
Score = 72.4 bits (176), Expect = 1e-12
Identities = 102/502 (20%), Positives = 203/502 (40%), Gaps = 57/502 (11%)
Query: 205 LDLAGNNIPGDVLRAVEQAMGHSQDR-------------LTTFQENQARTHVLSKEVQHL 251
L+ A + GD+ A E M D+ ++ Q L ++Q
Sbjct: 1052 LERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKK 1111
Query: 252 REEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAA 311
+E + +L E I+ +R AK+ + + +L+E A A+++M +
Sbjct: 1112 IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKR 1171
Query: 312 LALSEQKAQDLGELLATAEQ-----------------EQLSLSQRQAKELKLEQQEAAER 354
A ++ +DL E E EQ+ QR ++L+ E+ E
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKME 1231
Query: 355 ESKLLRDLSAANEKNLLLQNQVDELE---RKFRCQQEQLFQTRQEMTSMSAELKMRAIQA 411
L ++ ++ L+ LE + + ++E+ + ++T+ A L+ + +
Sbjct: 1232 IDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEY 1291
Query: 412 EERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLE----- 466
+LD EK L + +++E + R LEE KA L+++R +
Sbjct: 1292 SRQLD-EKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQ 1350
Query: 467 -EELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQ 525
EE KA +A E+ + +++ + QR LE+ + LAQ +A+
Sbjct: 1351 YEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEA 1410
Query: 526 QKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQA 585
A + +L +VE L +E + D+++ ++ E +++ A
Sbjct: 1411 VNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQ-RNFDKILAEWKQKCEETHA 1469
Query: 586 ELAAQEALREKAAALERQLKVMASDHREAL-----LDRESEN-----ASLREKLR---LR 632
EL EA ++++ +L +L + + + E+L L RE++N + L E++ R
Sbjct: 1470 EL---EASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1526
Query: 633 EAEIARIRDEEAQRASFLQNAV 654
E+ +I+ + Q S LQ A+
Sbjct: 1527 IHELEKIKKQVEQEKSELQAAL 1548
Score = 71.6 bits (174), Expect = 2e-12
Identities = 98/473 (20%), Positives = 195/473 (41%), Gaps = 73/473 (15%)
Query: 254 EKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALA 313
E K+ ++ E +K +EE+AK+ A+ +L+E + N L+ ++Q +LA
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTE----AKRKELEEKMVTLMQEKNDLQLQVQAEADSLA 903
Query: 314 LSEQKAQDL-----------GELLATAEQEQLSLSQRQAKELKLEQQ--EAAERESKLLR 360
+E++ L E+ AE E+ ++ AK+ KLE + E + L
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 963
Query: 361 DLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSA--ELKMRAIQAEE----- 413
L+ ++ +N+V L + E + + +E ++ + + +QAEE
Sbjct: 964 TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNT 1023
Query: 414 ------RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEE 467
+L+ + SLE + +R+ ++E R LE K QE +E + L+E
Sbjct: 1024 LTKAKIKLEQQVDDLEGSLEQEKKIRM-DLERAKRKLEGDLKLAQESTMDIENDKQQLDE 1082
Query: 468 ELSR-----------------------VKAAALSERGQAEEELIKAKSQARLEEQQRLAH 504
+L + K L R + EE I+A+ +R + +++ +
Sbjct: 1083 KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSD 1142
Query: 505 LEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQE 564
L +L +++ +EA GA Q ++ + + ++ +E + E L K +
Sbjct: 1143 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1202
Query: 565 RVAE-------VSRVRVELQEQNGRLQAEL----AAQEALREKAAALERQLKVMASDHRE 613
VAE + RV+ +L+++ ++ E+ + E + + LE+ + + D
Sbjct: 1203 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRAL-EDQLS 1261
Query: 614 ALLDRESENASL-------REKLRLREAEIARIRDEEAQRASFLQNAVLAYVQ 659
+ +E E L R +L+ E +R DE+ S L A+ Q
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQ 1314
Score = 62.8 bits (151), Expect = 1e-09
Identities = 100/480 (20%), Positives = 208/480 (43%), Gaps = 67/480 (13%)
Query: 222 QAMGHSQDRLTT-FQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQR-EEMAKSSRA 279
Q+ H D L ++E Q L + + E + Q+ ET QR EE+ ++ +
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVA-QWRTKYETDAIQRTEELEEAKKK 1396
Query: 280 SAARVGQLQE---ALNERHSIINALKAKLQ-----------MTEAALALSEQKAQDLGEL 325
A R+ +E A+N + + + K +LQ T AA A ++K ++ ++
Sbjct: 1397 LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI 1456
Query: 326 LATAEQE------QLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDEL 379
LA +Q+ +L SQ++++ L E + + L L +N LQ ++ +L
Sbjct: 1457 LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL 1516
Query: 380 ERKFRCQQEQLF-------QTRQEMTSMSAELKMRAIQAEE------RLDMEKRRCRQSL 426
+ +++ Q QE + + A L+ E R+ +E + + +
Sbjct: 1517 TEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEV 1576
Query: 427 EDSESLRIKEVEHMTRHLEESEKAMQERVQ-----RLEAARLS--LEEELSRVKAAALSE 479
+ + + +E++ M R+ ++MQ + R +A RL +E +L+ ++
Sbjct: 1577 DRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1636
Query: 480 RGQAEEELIKAKS-QARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVS 538
A E L ++ QA L++ Q HL+D LR +++ +A + R +
Sbjct: 1637 NRMAAEALRNYRNTQAILKDTQ--LHLDDALRSQEDLKEQ-----------LAMVERRAN 1683
Query: 539 QLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAA 598
L ++E LR LE+ ++ + +QE + RV++ L QN L + ++ L +
Sbjct: 1684 LLQAEIEELRATLEQTERSRKIAEQELLDASERVQL-LHTQNTSL---INTKKKLETDIS 1739
Query: 599 ALERQLKVMASDHREALLDRE---SENASLREKLRLRE---AEIARIRDEEAQRASFLQN 652
++ +++ + + R A + ++ A + E+L+ + A + R++ Q LQ+
Sbjct: 1740 QIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1799
Score = 40.4 bits (93), Expect = 0.005
Identities = 75/345 (21%), Positives = 137/345 (39%), Gaps = 80/345 (23%)
Query: 162 EELALALKGNTTLQQLDLRWNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVE 221
+ + L K L +++++ N+ + AL N + L D ++
Sbjct: 1614 DAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAIL-----------KDTQLHLD 1662
Query: 222 QAMGHSQDRLTTFQENQARTHVLSKEVQHLRE-----EKSK-----QFLDLMETID---K 268
A+ +D + R ++L E++ LR E+S+ + LD E +
Sbjct: 1663 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1722
Query: 269 QREEMAKSSRASAARVGQLQEALNERHSIINAL-----KAKLQMTEAALALSE------- 316
Q + + + + Q+Q E II KAK +T+AA+ E
Sbjct: 1723 QNTSLINTKKKLETDISQIQ---GEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDT 1779
Query: 317 ------------QKAQDLGELLATAEQEQLSLSQRQAKELKLEQQE-AAERESKLLRDLS 363
Q +DL L AEQ L ++Q ++L+ +E E ES+ R++
Sbjct: 1780 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVE 1839
Query: 364 AA-------------------NEKNLL-LQNQVDELERKFRCQQEQLFQTRQEMTSMSAE 403
A + KN+L LQ+ VD+L+ K + + Q + +E ++++
Sbjct: 1840 AVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQA-EEAEEQSNVNLS 1898
Query: 404 LKMRAIQAEERLDMEKRRCRQSLEDSE--SLRIKEVEHMTRHLEE 446
K R IQ E +E+ R + +S+ LR+K E T+ + E
Sbjct: 1899 -KFRRIQHE----LEEAEERADIAESQVNKLRVKSREVHTKIISE 1938
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 87.4 bits (215), Expect = 4e-17
Identities = 111/453 (24%), Positives = 203/453 (44%), Gaps = 45/453 (9%)
Query: 221 EQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRAS 280
EQ ++ R+ QE + S+E++ + +Q DL K +E + K
Sbjct: 814 EQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYE--- 870
Query: 281 AARVGQLQEAL-------NERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQ 333
+ QL+EAL E S AL+ +L+ + L+ + Q+ + L E L E EQ
Sbjct: 871 -GEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKE-ESEQ 928
Query: 334 LSLSQRQAKELKLEQQEAAERESKLLRDLS----AANEKNLLLQNQVDELERKFRCQQEQ 389
+R E++ E+ + KL ++++ A+ L LQNQ+DE + K R + +
Sbjct: 929 KEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAE 988
Query: 390 LFQTRQEMTSMSAELKMRA--IQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLE-- 445
+ + +E T + + ++ A +Q E RL E+ R Q +D + + +E + LE
Sbjct: 989 MQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYE 1048
Query: 446 -ESEKAMQERVQRL------EAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEE 498
E++ +++ RL + ++L +E E R + LSER E ++ L+E
Sbjct: 1049 LEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQE 1108
Query: 499 QQRLAHLE-DKLRLLAQARD------EAQGACLQQKQ-VVAEAQTRVSQLGLQVEGLRRR 550
+ LE DK+ L Q +D +G+ K+ +V + + R+++L ++E R
Sbjct: 1109 RAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERD 1168
Query: 551 LEELQ---QELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQ----EALREKAAALERQ 603
LQ + L K +E V +V + L +Q +L L A E E+ LE
Sbjct: 1169 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESS 1228
Query: 604 LKVMASDHREALLDRE---SENASLREKLRLRE 633
K + + E + E + S+++ LRL++
Sbjct: 1229 KKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKK 1261
Score = 77.0 bits (188), Expect = 5e-14
Identities = 108/453 (23%), Positives = 204/453 (45%), Gaps = 55/453 (12%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
+R ++ + D L + + ++ R ++ L + K + DL+ ++Q + + K
Sbjct: 700 IRDLQDQLSEMHDELDSAKRSEDREK--GALIEELLQAK-QDLQDLLIAKEEQEDLLRKR 756
Query: 277 SRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLA----TAEQE 332
R A G L+E ++ ++ LK + AL S ++A E+LA T+EQ+
Sbjct: 757 ERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQD 816
Query: 333 QLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQ 392
Q R +KL Q+E NEK LQ + +ELER+ Q Q+
Sbjct: 817 QAGTEMR----VKLLQEE---------------NEK---LQGRSEELERRVAQLQRQIED 854
Query: 393 TRQEMTSMSAELKM---RAIQAEERL------DMEKRRCRQSLEDSESLRIKEVEHMTRH 443
+ + LK Q EE L + E R++LE+ + T+
Sbjct: 855 LKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQE 914
Query: 444 LEE-SEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAE-EELIKAKSQARLEEQQR 501
++ SEK +E Q+ + RL E E R E+ Q E ++++A + LE Q +
Sbjct: 915 QKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQ 974
Query: 502 LAHLEDK-LRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSL 560
L ++K R LA+ + + L++K + AE ++R++ + +Q E R +EE L
Sbjct: 975 LDEYKEKNRRELAEMQRQ-----LKEKTLEAE-KSRLTAMKMQDE--MRLMEE-----EL 1021
Query: 561 KDQERVAEVSRVRVELQEQNGR-LQAELAAQEALREKAAALERQLKVMASDHREALLDRE 619
+D +R + + + +L EQ + L+ EL A+ L++ + L +Q++ S L +
Sbjct: 1022 RDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEER 1081
Query: 620 SENASLREKLRLREAEIARIRDEEAQRASFLQN 652
+ + L E++ ++ ++R+E Q + Q+
Sbjct: 1082 NNSDLLSERISRSREQMEQLRNELLQERAARQD 1114
Score = 73.9 bits (180), Expect = 4e-13
Identities = 87/376 (23%), Positives = 165/376 (43%), Gaps = 41/376 (10%)
Query: 314 LSEQKAQ---DLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNL 370
L EQK++ ++ EL Q QL L + + +K E++ +L + E+N
Sbjct: 612 LLEQKSKLTIEVAEL-----QRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENS 666
Query: 371 LLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE 430
LQ +++E E + R E+LFQ + E E++ Q E D E ++S + +
Sbjct: 667 TLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHD-ELDSAKRSEDREK 725
Query: 431 SLRIKEVEHMTRHL-------EESEKAMQERVQRLEAARLSLEEELSR------------ 471
I+E+ + L EE E +++R + L A + +L+EE+S
Sbjct: 726 GALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQY 785
Query: 472 -VKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVV 530
+ AL E + + ++ + +Q A E +++LL + ++ QG
Sbjct: 786 DAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS------- 838
Query: 531 AEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQ 590
E + RV+QL Q+E L+ +E + + +LK E E+ ++ L + ++A+
Sbjct: 839 EELERRVAQLQRQIEDLKG--DEAKAKETLKKYE--GEIRQLEEALVHARKEEKEAVSAR 894
Query: 591 EALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIRDEEAQRASFL 650
AL + A + L + ++ L ++ E + +E+LR + E+ R + L
Sbjct: 895 RALENELEAAQGNLSQTTQEQKQ-LSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKL 953
Query: 651 QNAVLAYVQASPVRTL 666
Q + V+AS TL
Sbjct: 954 QKEMADIVEASRTSTL 969
Score = 68.6 bits (166), Expect = 2e-11
Identities = 101/472 (21%), Positives = 189/472 (40%), Gaps = 53/472 (11%)
Query: 209 GNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDK 268
GNN + V+ + E Q + + K Q+++EE+ + +L E +
Sbjct: 598 GNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQ 657
Query: 269 QREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLAT 328
E++ ++S LQ+ L E + +L + + + +DL + L+
Sbjct: 658 HNEKVEENST--------LQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSE 709
Query: 329 AEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQE 388
E S + + +E +E + + L L A E+ LL+ + EL +E
Sbjct: 710 MHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKE 769
Query: 389 QLFQTRQEMTSMSAE-------LKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMT 441
++ QEM + + L+ +A + +++ R S +D E
Sbjct: 770 EVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAG-----TEMRV 824
Query: 442 RHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQAR-LEEQQ 500
+ L+E + +Q R + LE L+ ++ +K + +A+E L K + + R LEE
Sbjct: 825 KLLQEENEKLQGRSEELERRVAQLQRQIEDLK----GDEAKAKETLKKYEGEIRQLEEAL 880
Query: 501 RLAHLEDK-----LRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQ 555
A E+K R L + AQG Q Q + ++ + Q E LRR E++
Sbjct: 881 VHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEME 940
Query: 556 Q---------ELSLKDQERVAEVSRV-RVELQEQNGRLQAELAAQEALREKAAALERQLK 605
E K+ + E SR +ELQ Q +E R + A ++RQLK
Sbjct: 941 NERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEY------KEKNRRELAEMQRQLK 994
Query: 606 VMASDHREALLDRESENASLREKLRLREAEI---ARIRDEEAQRASFLQNAV 654
+ ++ L +++++RL E E+ R +DE + L+ +
Sbjct: 995 EKTLEAEKSRLTA----MKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTL 1042
Score = 48.1 bits (113), Expect = 3e-05
Identities = 51/244 (20%), Positives = 110/244 (45%), Gaps = 25/244 (10%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKS---KQFLDLMETIDKQRE 271
D RA ++A+ Q T ++ + S HL++++S KQ D + ++ + E
Sbjct: 1023 DYQRAQDEALTKRQLLEQTLKDLEYELEAKS----HLKDDRSRLVKQMEDKVSQLEMELE 1078
Query: 272 EMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ 331
E +S + R+ + +E + + + + +A Q E E++ +DL + E
Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEG 1138
Query: 332 EQLS-----LSQRQAKELKLEQQ-EAAER------------ESKLLRDLSAANEKNLLLQ 373
S + Q +A+ +LE + E+ ER E K+ + ++++L L
Sbjct: 1139 SYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLT 1198
Query: 374 NQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLR 433
+Q D+L + + + Q+ + +E+ + + K + EE++DM + Q + LR
Sbjct: 1199 DQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
Query: 434 IKEV 437
+K++
Sbjct: 1259 LKKL 1262
Score = 33.5 bits (75), Expect = 0.65
Identities = 37/229 (16%), Positives = 100/229 (43%), Gaps = 26/229 (11%)
Query: 208 AGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMET-- 265
A +++ D R V+Q +E + + +LS+ + RE+ + +L++
Sbjct: 1051 AKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERA 1110
Query: 266 ----IDKQREEMAKSSRASAARVGQLQEAL-NERHSIINALKAKLQMTEAALALSEQKAQ 320
++ + + + ++ +R+ L+ + + + ++ ++A++ E L E+
Sbjct: 1111 ARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRA 1170
Query: 321 DLG-----------ELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKN 369
+L EL+ + E LSL+ ++ + + R + R + A E+
Sbjct: 1171 NLQLSNRRLERKVKELVMQVDDEHLSLTD--------QKDQLSLRLKAMKRQVEEAEEEI 1222
Query: 370 LLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDME 418
L++ +L+R+ Q + + ++ SM +L+++ + ++ DM+
Sbjct: 1223 DRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKKLPSKVLDDMD 1271
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 87.0 bits (214), Expect = 5e-17
Identities = 96/446 (21%), Positives = 193/446 (43%), Gaps = 46/446 (10%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKS 276
+R E+ M +RL +E + ++V+ +REEK Q E K R++ K
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQ-----EQEKKTRDQEEKM 446
Query: 277 SRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQ--EQL 334
R+ + ++ + E + + K+Q E + E+K L E+ EQ
Sbjct: 447 QEEE--RIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 504
Query: 335 SLSQRQAK-----ELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQ 389
+ +++ K E +Q+E +E K+ R EK ++Q+ E E K R Q+++
Sbjct: 505 KMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQ-----EKMREQEDQMWEQEEKMRDQEQK 559
Query: 390 LFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEK 449
++ + M + E + + EE++ E+R + + E +++E E M R EE +
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQEEKMREEER-----MREREK-KMREEEEMMREQEEKMQ 613
Query: 450 AMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARL------------- 496
+E++Q E EE++ + + + E+ K Q RL
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 673
Query: 497 EEQQRLAHLEDKL----RLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLE 552
+EQ+++ E+K+ ++ + +++ + Q+K E+ + + E + R E
Sbjct: 674 QEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQE 733
Query: 553 ELQQELSLKDQERVAEVSRVRVELQEQNGRL--QAELAAQEALREKAAALERQLKVMASD 610
E QE K QE+ E+ ++ EQ ++ Q L Q+ + ++ Q K+ +
Sbjct: 734 EKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIW--E 791
Query: 611 HREALLDRESENASLREKLRLREAEI 636
E + D+E + EK+R +E ++
Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKM 817
Score = 75.9 bits (185), Expect = 1e-13
Identities = 110/469 (23%), Positives = 195/469 (41%), Gaps = 82/469 (17%)
Query: 196 LPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEK 255
L R L+L N I + L+ + Q++L + ++ + KE++ + E+
Sbjct: 202 LTKERDALSLELYRNTITNEELKKKNAEL---QEKLPLAESEKSEIQLNVKELKR-KLER 257
Query: 256 SKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALS 315
+K L ++T Q E + + +E L E+ I + K+ E L
Sbjct: 258 AKFLLPQVQTNTLQEE------------MWRQEEELREQEKKIRKQEEKMWRQEERLREQ 305
Query: 316 EQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQ 375
E K + EQ RQ K L+ +++E E+E K LR+ E+ +Q Q
Sbjct: 306 EGKMR-----------EQEEKMWRQEKRLREQEKELREQE-KELREQKELREQEEQMQEQ 353
Query: 376 VDEL---ERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESL 432
+++ E K R Q+E+++ RQE E +MR Q ++ D E+R Q E L
Sbjct: 354 EEKMWEQEEKMREQEEKMW--RQEERLWEQEKQMRE-QEQKMRDQEERMWEQD----ERL 406
Query: 433 RIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKS 492
R KE + E EK M E+V+++ + E+E K E EEE I+ +
Sbjct: 407 REKE-----ERMREQEK-MWEQVEKMREEKKMQEQE----KKTRDQEEKMQEEERIRERE 456
Query: 493 QARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLE 552
+ EE++ + E+K+ QKQ E + Q + L + E
Sbjct: 457 KKMREEEETMREQEEKM----------------QKQ--EENMWEQEEKEWQQQRLPEQKE 498
Query: 553 ELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHR 612
+L ++ +++QE ++ QE+ + ++ QE +RE+ + Q + M D
Sbjct: 499 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM-RDQE 557
Query: 613 EALLDRE---------------SENASLREKLRLREAEIARIRDEEAQR 646
+ + D+E + +RE+ R+RE E +EE R
Sbjct: 558 QKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
Score = 70.5 bits (171), Expect = 5e-12
Identities = 90/442 (20%), Positives = 191/442 (43%), Gaps = 38/442 (8%)
Query: 217 LRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQF-LDLMETIDKQREEMAK 275
+R E+ M ++++ +EN + Q L E+K K + + M+ +++ E +
Sbjct: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518
Query: 276 SSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLS 335
R GQ E R + + ++ E + EQK D E + QEQ
Sbjct: 519 KIRDQEEMWGQ--EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEK 576
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
+ Q ++++ E++ ERE K+ + E+ +Q Q E K + Q+E++++ +
Sbjct: 577 KTWDQEEKMR-EEERMREREKKMREEEEMMREQEEKMQEQ----EEKMQEQEEKMWEQEE 631
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERV 455
+M ++ Q E+ + E++ Q + ++ E E M +E EK MQE+
Sbjct: 632 KMQEQEEKMWE---QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM----QEQEK-MQEQE 683
Query: 456 QRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQA 515
+++ +E++ + + EEE ++ + + EE++ + E+K++ +
Sbjct: 684 EKIWEQE-KMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEK 742
Query: 516 RDEAQGACLQQKQVVAEAQTRV---SQLGLQVEGL--RRRLEE----LQQELSLKDQERV 566
E + +Q++ + E + ++ +L Q E L +++E +QE ++DQE
Sbjct: 743 MQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEK 802
Query: 567 AEVSRVRVELQEQNGRLQAE-LAAQE-----------ALREKAAALERQLKVMASDHREA 614
++ QE+ R Q E + QE EK E +++ E
Sbjct: 803 MRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEK 862
Query: 615 LLDRESENASLREKLRLREAEI 636
+ ++E + EK+R +E ++
Sbjct: 863 MREQEEKMRGQEEKMREQEEKM 884
Score = 69.3 bits (168), Expect = 1e-11
Identities = 101/433 (23%), Positives = 190/433 (43%), Gaps = 53/433 (12%)
Query: 248 VQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSI-INALKAKLQ 306
++ L +E+ L+L E K++ +L A +E+ I +N + K +
Sbjct: 199 IEELTKERDALSLELYRNTITNEELKKKNAELQE----KLPLAESEKSEIQLNVKELKRK 254
Query: 307 MTEAALALSEQKAQDLGELLATAEQE---QLSLSQRQAKELKLEQQEAAERESKL----- 358
+ A L + + L E + E+E Q ++Q +++ +++ E+E K+
Sbjct: 255 LERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEE 314
Query: 359 --------LRDLS---AANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMR 407
LR+ EK L Q ++ E E + + Q+E++++ ++M E + +
Sbjct: 315 KMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKM----REQEEK 370
Query: 408 AIQAEERL---DMEKRRCRQSLEDSESLRIKEVEHMTRHLEE---SEKAMQERVQRLEAA 461
+ EERL + + R Q + D E R+ E + R EE ++ M E+V+++
Sbjct: 371 MWRQEERLWEQEKQMREQEQKMRDQEE-RMWEQDERLREKEERMREQEKMWEQVEKMREE 429
Query: 462 RLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLR-----LLAQAR 516
+ E+E K E EEE I+ + + EE++ + E+K++ + Q
Sbjct: 430 KKMQEQE----KKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 485
Query: 517 DEAQGACL-QQKQVVAE---AQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRV 572
E Q L +QK+ + E Q + ++ Q E +R + E QE + QE++ E
Sbjct: 486 KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 545
Query: 573 RVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLR 632
E +E+ + ++ QE EK E++ K D E + RE E REK
Sbjct: 546 MWEQEEKMRDQEQKMWDQEERMEKKTQ-EQEKKTW--DQEEKM--REEERMREREKKMRE 600
Query: 633 EAEIARIRDEEAQ 645
E E+ R ++E+ Q
Sbjct: 601 EEEMMREQEEKMQ 613
Score = 55.5 bits (132), Expect = 2e-07
Identities = 61/334 (18%), Positives = 148/334 (44%), Gaps = 41/334 (12%)
Query: 217 LRAVEQAMGHSQDRLTT-FQENQART-----HVLSKEVQHLREEKSKQFLDLMETIDKQR 270
+R EQ M ++R+ QE + +T + +E RE+K ++ ++M +++
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKM 612
Query: 271 EEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAAL----ALSEQKAQDLGELL 326
+E + + ++ + +E + E+ + + K+ E + L EQK + L E
Sbjct: 613 QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQK-EKLWEHE 671
Query: 327 ATAEQEQLS-----LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVD---E 378
EQE++ + +++ E K ++QE + + +R+ + E+ ++ + + E
Sbjct: 672 KMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE 731
Query: 379 LERKFRCQQEQLFQTRQEMTSMSAEL--KMRAIQAEERLDMEKRRCRQSLEDSESLRIKE 436
E K + Q+E++ + +EM ++ + + ++RL +K + + + E +I E
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791
Query: 437 VEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAA-------------------- 476
E R EE + +E+++ E EE++ +
Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEK 851
Query: 477 LSERGQAEEELIKAKSQARLEEQQRLAHLEDKLR 510
+ E+ Q +EE ++ + + +++++ E+K+R
Sbjct: 852 MEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885
Score = 47.0 bits (110), Expect = 6e-05
Identities = 72/322 (22%), Positives = 130/322 (40%), Gaps = 19/322 (5%)
Query: 337 SQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQE--QLFQTR 394
+Q+ +LK E++ + + + L R++ A + +L Q ELE Q+ + F+
Sbjct: 72 TQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFEDG 131
Query: 395 QEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQER 454
T S L + L + R+ H L+ + A+ R
Sbjct: 132 NLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRALSAVSTR 191
Query: 455 VQRL---------EAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHL 505
++ E LSLE + + L ++ +E + + E Q + L
Sbjct: 192 HKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKEL 251
Query: 506 EDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQ--LGLQVEGLRRRLEEL-QQELSLKD 562
+ KL + Q LQ++ E + R + + Q E + R+ E L +QE +++
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 311
Query: 563 QERVAEVSRVRVELQEQNGRLQ-AELAAQEALREKAAALERQLKVMASDHREALLDRESE 621
QE R+ QE+ R Q EL Q+ LRE+ ++ Q + M + RE E
Sbjct: 312 QEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKM---REQE 368
Query: 622 NASLREKLRLREAEIARIRDEE 643
R++ RL E E ++R++E
Sbjct: 369 EKMWRQEERLWEQE-KQMREQE 389
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 86.7 bits (213), Expect = 6e-17
Identities = 101/453 (22%), Positives = 212/453 (46%), Gaps = 55/453 (12%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQL 287
++ + + ++ + + +V+ L+EE S + + Q EE+ K + A +GQ+
Sbjct: 420 EEEMKQMEVYRSHSKFMKNKVEQLKEELSSK--------EAQWEELKKKAAGLQAEIGQV 471
Query: 288 QEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSL-SQRQAKELKL 346
++ L+ + + + AL+ KL+ + S+Q + L E L EQ L ++ A L+L
Sbjct: 472 KQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 531
Query: 347 EQQEA-AERESKLLRDLSAANEKNL-------------LLQNQVDELERKFRCQQEQLFQ 392
E++E +++K ++D+ A EK + + +V+ L++K QEQL
Sbjct: 532 EEKETMLNKKTKQIQDM--AEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRD 589
Query: 393 TRQEMTSMSAELKM---------RAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRH 443
++M+S+ +K A+ E EK R + L++ +E + +
Sbjct: 590 KEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDN 649
Query: 444 LEESEKAMQERVQRLEAARLSLEEELSRVK--AAALSERGQAEEELIKAKSQARLEEQQR 501
++ K ++E+V L+ E L +K A++L+ G ++ +K A ++++
Sbjct: 650 YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 709
Query: 502 LAHLEDKLR------LLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQ 555
+E +L+ L A+A E ++ + + S+ +V+ L L+E++
Sbjct: 710 CLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVE 769
Query: 556 QELSLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREAL 615
E + KD +++AE+ R ++++QN ++ A L +E + +K +A Q+ A + L
Sbjct: 770 NEKNDKD-KKIAELER---QVKDQNKKV-ANLKHKEQVEKKKSA---QMLEEARRREDNL 821
Query: 616 LDRESENASLREKLRLREAEIARIRDEEAQRAS 648
D + L++ LR ++ I + EEA R S
Sbjct: 822 NDSSQQ---LQDSLRKKDDRIEEL--EEALRES 849
Score = 83.6 bits (205), Expect = 6e-16
Identities = 104/458 (22%), Positives = 195/458 (42%), Gaps = 60/458 (13%)
Query: 235 QENQARTHVLSKEVQHLREEKSKQ---FLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
+E + + +K++Q + EEK Q DL + +D + ++ + ++ LQE L
Sbjct: 532 EEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK----KIENLQEQL 587
Query: 292 NERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEA 351
++ +++LK +++ +A ++ L E LA E+ L +++ ++ + E+QE
Sbjct: 588 RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER-EKQEE 646
Query: 352 AERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQA 411
+ K L+DL EK LLQ + E E +E + LK I
Sbjct: 647 IDNYKKDLKDLK---EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 703
Query: 412 EER----LDMEKR---------RCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE----- 453
E++ L ME + R S E S+ ++ E E +TR+ +ES KA E
Sbjct: 704 EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE-ITRYKDESSKAQAEVDRLL 762
Query: 454 ------------------------RVQRLEAARLSLEEELSRVKAAALSERGQAEEELIK 489
+ Q + A L +E++ + K+A + E + E+ +
Sbjct: 763 EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 822
Query: 490 AKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRR 549
SQ + Q L +D++ L +A E+ +++ V+A+ ++ + QVE L
Sbjct: 823 DSSQ---QLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLM 879
Query: 550 RLEELQQEL-SLKDQERVAEVSRVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMA 608
+E+++QEL S+K + + S E N R + +E L K AL +
Sbjct: 880 AMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEAL--LAAISE 937
Query: 609 SDHREALLDRESENASLREKLRLREAEIARIRDEEAQR 646
D ALL+ S +E++ + E R+ + Q+
Sbjct: 938 KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQ 975
Score = 58.5 bits (140), Expect = 2e-08
Identities = 85/368 (23%), Positives = 162/368 (44%), Gaps = 61/368 (16%)
Query: 330 EQEQLSLSQRQAK-----ELKLEQQEAAERESKLL---RDLSAANEKNLLLQNQVDELER 381
++ +LS S K ELK E+ + SK+ E+N +Q + L+
Sbjct: 175 KESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234
Query: 382 KFRCQQE--QLFQTRQEMTSMSAELKMRAIQAE--ERLDMEKRRCRQSLEDSESLRIKEV 437
+ R Q++ QLFQ Q+ +S + E + + E +RL E R + KE+
Sbjct: 235 ELRIQRDLNQLFQ--QDSSSRTGEPCVAELTEENFQRLHAEHER-----------QAKEL 281
Query: 438 EHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLE 497
+ + LEE E ++ + Q L A S+++ L +++ LS + E+ +++ E
Sbjct: 282 FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDH---ERTRRLAE 338
Query: 498 EQQRLAHLEDKL---------------RLLAQARDEAQGACLQQKQVVAEAQTRVSQLGL 542
+ + HLE L R A D A+ LQ V+ +++S +
Sbjct: 339 AEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQ--TVIEMKDSKISSMER 396
Query: 543 QVEGLRRRLEELQQELSLKDQERVAEVSRVRVE------LQEQNGRLQAELAAQEA---- 592
+ L ++ L+ +L +ER E+ ++ V ++ + +L+ EL+++EA
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEE 456
Query: 593 LREKAAALER---QLKVMASDHREALLDRESENASLREKLRLREAEIARIRDE---EAQR 646
L++KAA L+ Q+K S LL +++ +L + + I +++ + QR
Sbjct: 457 LKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR 516
Query: 647 ASFLQNAV 654
A+ LQ V
Sbjct: 517 AAILQTEV 524
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 86.7 bits (213), Expect = 6e-17
Identities = 106/466 (22%), Positives = 207/466 (44%), Gaps = 57/466 (12%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQL 287
QD + Q R H L K+ + E S+ + QRE++ + A L
Sbjct: 1440 QDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQRE-KLQREKLQREKDMLLAEAFSL 1498
Query: 288 QEALNERHSIINALKAKLQMTEAALA-LSEQKAQD----------LGELLATAEQEQLSL 336
++ L E+ I K+ EA L +S Q+++D L +L A + ++ L
Sbjct: 1499 KQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEEL 1558
Query: 337 SQR--------QAK---ELKLE---QQEAAERESKLLRDLSAANEKNLLLQNQVDELERK 382
++ QAK E+++E Q + E ES+ A L+ +LE +
Sbjct: 1559 DEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEE 1618
Query: 383 FRCQQEQLFQTRQ---EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESL------- 432
+ +Q+ L + R+ ++ ++S ++ R ++E+RL + +R + L D++ +
Sbjct: 1619 YEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNS 1678
Query: 433 --RIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEE------ELSRVKAAALSERGQAE 484
+E+ + LEESE V+ +A + +E+ ++++ K A + + +
Sbjct: 1679 APSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQ 1738
Query: 485 EELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQV 544
E K + Q RLEE Q ED L+ + + A Q+ + Q ++ + +
Sbjct: 1739 RE--KNEIQNRLEEDQ-----EDMNELMKKHKAAVAQASRDLAQI-NDLQAQLEEANKEK 1790
Query: 545 EGLRRRLEELQQELSLKDQERVAE--VSRVRVELQEQNGRLQAELAAQEALREKAAALER 602
+ L+ +L+ LQ ++ +Q V + VSR +++E RL+ E + L A+ L+
Sbjct: 1791 QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKE 1850
Query: 603 QLKVMAS--DHREALLDRESE-NASLREKLRLREAEIARIRDEEAQ 645
++ + D R A +RE E N L+ +LR + E+ + +EA+
Sbjct: 1851 NMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAE 1896
Score = 71.6 bits (174), Expect = 2e-12
Identities = 90/415 (21%), Positives = 179/415 (43%), Gaps = 72/415 (17%)
Query: 244 LSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKA 303
LS+E ++E+ +Q +E +K+R E+ +S +R+ +L L + N ++
Sbjct: 1251 LSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDER---NTGES 1307
Query: 304 KLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLS 363
Q+ +A A + +++ EL Q Q ++Q + +++E EA R +
Sbjct: 1308 ASQLLDAETAERLRAEKEMKEL-----QTQYDALKKQMEVMEMEVMEA--------RLIR 1354
Query: 364 AANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCR 423
AA + +VD+ E +++ +A +D K+R +
Sbjct: 1355 AAE-----INGEVDD-------------------DDAGGEWRLKYERAVREVDFTKKRLQ 1390
Query: 424 QSLEDSESLRIKEVEHMTRHL-------EESEKAMQE---RVQRLEA----ARLSLEEEL 469
Q ED + + + R L EES++A+Q+ + QRL A +L LE +
Sbjct: 1391 QEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQ 1450
Query: 470 SRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQV 529
R +R + + EL +A +A+ E+ QR +K LLA+A KQ
Sbjct: 1451 VRNHELEKKQR-RFDSELSQAHEEAQREKLQREKLQREKDMLLAEA--------FSLKQQ 1501
Query: 530 VAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSR----VRVELQEQNGRLQA 585
+ E ++ +V L L+++ + S KD+ +A+V + + ++++Q L
Sbjct: 1502 LEEKDMDIAGFTQKVVSLEAELQDISSQES-KDEASLAKVKKQLRDLEAKVKDQEEELDE 1560
Query: 586 ELAAQEALREKAAALERQLKVMASDHREALLDRESE----NASLREKLRLREAEI 636
+ + L + LE +++ M H + + R+ E S ++KL+ E ++
Sbjct: 1561 QAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQL 1615
Score = 69.3 bits (168), Expect = 1e-11
Identities = 101/431 (23%), Positives = 197/431 (45%), Gaps = 59/431 (13%)
Query: 246 KEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKL 305
+EV ++ ++F D +E + + ++ + R+G LQ E + LK K
Sbjct: 1380 REVDFTKKRLQQEFEDKLEVEQQNKRQLER-------RLGDLQADSEESQRALQQLKKKC 1432
Query: 306 QMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAA 365
Q A L + K G+ + E E+ QR+ + E A+RE KL R+
Sbjct: 1433 QRLTAEL--QDTKLHLEGQQVRNHELEK---KQRRFDSELSQAHEEAQRE-KLQRE-KLQ 1485
Query: 366 NEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEERLDMEKRRCRQS 425
EK++LL + L+++ + + Q++ S+ AEL+ + Q E + + + ++
Sbjct: 1486 REKDMLLA-EAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQ-ESKDEASLAKVKKQ 1543
Query: 426 LEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEE 485
L D E+ ++K+ E E E+A +Q LE A+L LE E+ R++ E +E
Sbjct: 1544 LRDLEA-KVKDQEE-----ELDEQA--GTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1595
Query: 486 ELIKAKSQARLEEQQRLAHL----EDKLRLLAQARD-EAQGACL---------------- 524
E+ +A+ + + +Q L EDK ++L + R+ E + A L
Sbjct: 1596 EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLR 1655
Query: 525 ----QQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEV---SRVRVELQ 577
+ K ++A+AQ + L +R + +L+ +L + A V + VE++
Sbjct: 1656 KDLKRTKALLADAQLMLDHLKNSAPS-KREIAQLKNQLEESEFTCAAAVKARKAMEVEIE 1714
Query: 578 EQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLRE-KLRLREA-- 634
+ + ++ A+ AL E+ + L+R+ + + E D+E N +++ K + +A
Sbjct: 1715 DLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEE---DQEDMNELMKKHKAAVAQASR 1771
Query: 635 EIARIRDEEAQ 645
++A+I D +AQ
Sbjct: 1772 DLAQINDLQAQ 1782
Score = 63.5 bits (153), Expect = 6e-10
Identities = 87/403 (21%), Positives = 179/403 (44%), Gaps = 56/403 (13%)
Query: 244 LSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVG-QLQEALNERHSIINA-- 300
L E++ +R+ SK+ ME+ D++ EE +S + ++ QL+E ++ ++
Sbjct: 1575 LEMEMERMRQTHSKE----MESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKR 1630
Query: 301 -LKAKL-----QMTEAALALSEQKAQDLGELLATAEQEQLSL--------SQRQAKELKL 346
L+ KL Q+ ++ +DL A QL L S+R+ +LK
Sbjct: 1631 ELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKN 1690
Query: 347 EQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKM 406
+ +E+ + ++ A + L Q+D++ + +EQL + ++E + L+
Sbjct: 1691 QLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEE 1750
Query: 407 RAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLE 466
E + K Q+ D + ++ + LEE+ K QE ++L+A + +E
Sbjct: 1751 DQEDMNELMKKHKAAVAQASRD-----LAQINDLQAQLEEANKEKQELQEKLQALQSQVE 1805
Query: 467 EELSRVKAAALSERGQAEEELIKAKSQARLEEQQRL----AHLEDKLRLLAQARDEAQGA 522
+ +L R +A+ ++ + + + +RL + L++ + L + RD+ A
Sbjct: 1806 FLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAA 1865
Query: 523 CLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVE------- 575
++K+ Q + L+R+L + ++E+ + + AE SR + E
Sbjct: 1866 ENREKE--------------QNKRLQRQLRDTKEEMG-ELARKEAEASRKKHELEMDLES 1910
Query: 576 LQEQNGRLQAEL-AAQEALREKAAALERQLKVMASDHREALLD 617
L+ N LQA+L A + + + AA+E + M SD E L++
Sbjct: 1911 LEAANQSLQADLKLAFKRIGDLQAAIEDE---MESDENEDLIN 1950
Score = 38.5 bits (88), Expect = 0.020
Identities = 56/263 (21%), Positives = 112/263 (42%), Gaps = 22/263 (8%)
Query: 215 DVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMA 274
++++ + A+ + L + QA+ +KE Q L +EK + +E +++ + +
Sbjct: 1757 ELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQEL-QEKLQALQSQVEFLEQSMVDKS 1815
Query: 275 KSSRASAARVGQLQEALNERHSIINALKAKL-QMTEAALALSEQKAQDLGELLATAEQEQ 333
SR A ++ +L+ L + + L++ ++ E L+E++ Q + E+EQ
Sbjct: 1816 LVSRQEA-KIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAA--ENREKEQ 1872
Query: 334 LSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQT 393
QRQ ++ K E E A +E++ A+ K L+ ++ LE + Q L
Sbjct: 1873 NKRLQRQLRDTKEEMGELARKEAE-------ASRKKHELEMDLESLEAANQSLQADLKLA 1925
Query: 394 RQEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQE 453
+ + + A AI+ E D E SL+D + + + LE E
Sbjct: 1926 FKRIGDLQA-----AIEDEMESD-ENEDLINSLQD----MVTKYQKRKNKLEGDSDVDSE 1975
Query: 454 RVQRLEAARLSLEEELSRVKAAA 476
R++ + L + KAA+
Sbjct: 1976 LEDRVDGVKSWLSKNKGPSKAAS 1998
>gi|34577114 cytomatrix protein p110 [Homo sapiens]
Length = 957
Score = 86.3 bits (212), Expect = 8e-17
Identities = 112/454 (24%), Positives = 211/454 (46%), Gaps = 56/454 (12%)
Query: 244 LSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKA 303
L E+Q L+ D E I KQ E S+ ++ QL++ L+++ S + AL+
Sbjct: 397 LEDEIQMLKANGVLNTEDREEEI-KQIEVYKSHSKFMKTKIDQLKQELSKKESELLALQT 455
Query: 304 KLQMTEAALALSEQKAQDLGELLATAEQEQLSL-SQRQAKELKLEQQEA-AERESKLLRD 361
KL+ + +Q + L E L EQ L ++ A L+LE++E+ +++K L+D
Sbjct: 456 KLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQD 515
Query: 362 LSAANEKNLLL-------------QNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRA 408
L+ EK L + +++ L++K QEQL +++T++ +K
Sbjct: 516 LT--EEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQ 573
Query: 409 IQA----------EERLDMEKR---RCRQSLEDSESLRIKEVEHMTRH---LEESEKAMQ 452
+ EE L ++R R ++ E + R++E+E + L+E A+Q
Sbjct: 574 TDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQ 633
Query: 453 ERVQRLEAARLSLEEELSRVKAAALSERGQAE--EELIKAKSQ--ARLEEQQRLAH-LED 507
+ E++ + L+E S + +A L + + E I+ K + ++LE Q + AH +ED
Sbjct: 634 AELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIED 693
Query: 508 KLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG---LQVEGLRRRLEELQQELSLKDQE 564
R+ + D Q KQ+ EA + G +V+ L L+E++ E + KD +
Sbjct: 694 DSRMNPEFAD-------QIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKD-K 745
Query: 565 RVAEVSRVRVELQEQNGRLQAELAAQEALREK--AAALE--RQLKVMASDHREALLDRES 620
++AE+ + + + + A L + L +K A LE R+ + +D+ + L E
Sbjct: 746 KIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEEL 805
Query: 621 ENA--SLREKLRLREAEIARIRDEEAQRASFLQN 652
NA R++L +A +A + A++ + L N
Sbjct: 806 MNALEKTRQELDATKARLASTQQSLAEKEAHLAN 839
Score = 72.4 bits (176), Expect = 1e-12
Identities = 106/466 (22%), Positives = 200/466 (42%), Gaps = 44/466 (9%)
Query: 196 LPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSKEVQHLREEK 255
L R L + + A ++ + +R + H Q + Q+ L+ +Q +
Sbjct: 190 LKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNR 249
Query: 256 SKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMTEAALALS 315
+ + T + R A+ R A + L++ L E ++ +++ + L
Sbjct: 250 GAEHFTIELTEENFRRLQAEHDR-QAKELFLLRKTLEE-------MELRIETQKQTLNAR 301
Query: 316 EQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQ 375
++ + L E+L + SL + ++ + E+ +++ D ++N+ L+
Sbjct: 302 DESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQK--EKENIHLR-- 357
Query: 376 VDELERKFRCQQE----QLFQTRQEMTSMS-AELKMRAIQAEERLDMEKRRCRQSLEDSE 430
+EL R+ + Q E + QT EM A L+ E+ + M K + ED E
Sbjct: 358 -EELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDRE 416
Query: 431 SLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELS--RVKAAALSERGQAEEELI 488
IK++E H K M+ ++ +L+ E EL + K LS + ++ I
Sbjct: 417 E-EIKQIEVYKSH----SKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHI 471
Query: 489 KAKSQARLEEQQRLAHLE---DKLRLLAQARDEAQGACLQQKQVVAE------AQTRVSQ 539
+ ++ ++QR A L+ D LRL + ++ +Q Q + E + R +
Sbjct: 472 EVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMK 531
Query: 540 LGLQVEG-----LRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQAELAA-QEAL 593
L+V+ L++++E LQ++L KD++ RV+ LQ + LA +EAL
Sbjct: 532 DMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVK-SLQTDSSNTDTALATLEEAL 590
Query: 594 REKAAALERQLKVMASDHREALLDRES---ENASLREKLRLREAEI 636
EK +ER + D RE L + ES EN L+EK+ +AE+
Sbjct: 591 SEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAEL 636
Score = 64.7 bits (156), Expect = 3e-10
Identities = 78/328 (23%), Positives = 154/328 (46%), Gaps = 32/328 (9%)
Query: 342 KELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMS 401
KE L ++EAA R S L + ++E+N LQ + L+ + R Q++ +QE +
Sbjct: 192 KERVLRKEEAA-RMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRG 250
Query: 402 A--------ELKMRAIQAE-ERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQ 452
A E R +QAE +R E R++LE+ E LRI+ + +ES K +
Sbjct: 251 AEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEME-LRIETQKQTLNARDESIKKLL 309
Query: 453 ERVQRLEAARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLL 512
E +Q SLE++ R + A +E + E+I ++++ HL ++L
Sbjct: 310 EMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILD------QKEKENIHLREELHRR 363
Query: 513 AQARDE-AQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSR 571
+Q + E A+ LQ V+ T+++ L + L ++ L+ L ++R E+ +
Sbjct: 364 SQLQPEPAKTKALQ--TVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQ 421
Query: 572 VRVE------LQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASL 625
+ V ++ + +L+ EL+ +E+ + AL+ +L+ +++ + + E SL
Sbjct: 422 IEVYKSHSKFMKTKIDQLKQELSKKES---ELLALQTKLETLSNQNSDCKQHIEVLKESL 478
Query: 626 ---REKLRLREAEIARIRDEEAQRASFL 650
++ + + E+ +R ++ SFL
Sbjct: 479 TAKEQRAAILQTEVDALRLRLEEKESFL 506
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 86.3 bits (212), Expect = 8e-17
Identities = 114/473 (24%), Positives = 215/473 (45%), Gaps = 70/473 (14%)
Query: 233 TFQENQARTHVLSKEVQHLREEKSKQFL------DLMETIDKQREEMAKSSRASAARVGQ 286
T ++++AR L +++ L +EK+ L D + +++ +++ K+ A+V +
Sbjct: 864 TLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKE 923
Query: 287 LQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKL 346
+ E L + + L AK + E + ++ DL LA E+E+ + ++ + K L
Sbjct: 924 MNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHA-TENKVKNLTE 982
Query: 347 EQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKM 406
E E +KL ++ A E + Q +D+L Q ++ + ++ K+
Sbjct: 983 EMAGLDEIIAKLTKEKKALQEAH---QQALDDL------------QVEEDKVNSLSKSKV 1027
Query: 407 RAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLE 466
+ Q + L+ SLE + +R+ ++E R LE K QE + LE +L LE
Sbjct: 1028 KLEQQVDDLE-------GSLEQEKKVRM-DLERAKRKLEGDLKLTQESIMDLENDKLQLE 1079
Query: 467 EELSRVKAAALSERGQAEEELIKA-KSQARLEEQQ-RLAHLEDKLRLLAQARDEAQGACL 524
E+L + + + + E+E + A + Q +L+E Q R+ LE++L AR + +
Sbjct: 1080 EKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRS 1139
Query: 525 QQKQVVAEAQTRVSQLG----LQVE----------GLRRRLEE--LQQE-----LSLKDQ 563
+ + E R+ + G +Q+E +RR LEE LQ E L K
Sbjct: 1140 DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHA 1199
Query: 564 ERVAE-------VSRVRVELQEQNGRLQAEL----AAQEALREKAAALE---RQLKVMAS 609
+ VAE + RV+ +L+++ + EL + E + + A LE R L+ A+
Sbjct: 1200 DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQAN 1259
Query: 610 DHREALLDRE---SENASLREKLRLREAEIARIRDEEAQRASFLQNAVLAYVQ 659
++R L + + ++ + R KL+ E+AR +E+ S L L+Y Q
Sbjct: 1260 EYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQ 1312
Score = 85.9 bits (211), Expect = 1e-16
Identities = 104/450 (23%), Positives = 205/450 (45%), Gaps = 37/450 (8%)
Query: 244 LSKEVQHLREEKSKQFLDL------METIDKQREEMAKSSRASAARVGQLQEALNERHSI 297
L + Q L +EKS+ L+L ME I K + + K SR + + + L E
Sbjct: 1212 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRS 1271
Query: 298 INAL---KAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQAKELKLEQQEAAER 354
+N +AKLQ LA ++ ++ L++ + +LS +Q Q ++LK + +E +
Sbjct: 1272 LNDFTTQRAKLQTENGELA---RQLEEKEALISQLTRGKLSYTQ-QMEDLKRQLEEEGKA 1327
Query: 355 ESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELKMRAIQAEER 414
++ L L +A LL+ Q +E Q L + E+ + + AIQ E
Sbjct: 1328 KNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEE 1387
Query: 415 LDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVKA 474
L+ K++ Q L+D+E ++ V LE+++ +Q ++ L ++ E S A
Sbjct: 1388 LEEAKKKLAQRLQDAEE-AVEAVNAKCSSLEKTKHRLQNEIE-----DLMVDVERSNAAA 1441
Query: 475 AALSERGQAEEELIK------AKSQARLEEQQRLAH-LEDKLRLLAQARDEAQGACLQQK 527
AAL ++ + ++++ +SQ+ LE Q+ A L +L L A +E+ K
Sbjct: 1442 AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFK 1501
Query: 528 QVVAEAQTRVSQLGLQV-EGLR--RRLEELQQELSLKDQERVAEVSRVRVELQEQNGR-L 583
+ Q +S L Q+ EG + LE+++++L ++ E + + L+ + G+ L
Sbjct: 1502 RENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKIL 1561
Query: 584 QAELAAQE---ALREKAAALERQLKVMASDHREAL----LDRESENASLREKLRLREAEI 636
+A+L + + K A + +++ +H+ + ++E S E LR+++
Sbjct: 1562 RAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKME 1621
Query: 637 ARIRDEEAQRASFLQNAVLAYVQASPVRTL 666
+ + E Q + + A A Q +++L
Sbjct: 1622 GDLNEMEIQLSHANRMAAEAQKQVKSLQSL 1651
Score = 67.8 bits (164), Expect = 3e-11
Identities = 93/450 (20%), Positives = 201/450 (44%), Gaps = 78/450 (17%)
Query: 235 QENQARTH---VLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSR----------ASA 281
+E +A+ VLSK + + ++K D ++ ++ E K ++ A
Sbjct: 1351 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVN 1410
Query: 282 ARVGQLQEALNERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQE------QLS 335
A+ L++ + + I L ++ + AA A ++K ++ ++LA +Q+ +L
Sbjct: 1411 AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELE 1470
Query: 336 LSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQ 395
SQ++A+ L E + + L L +N LQ ++ +L EQL + +
Sbjct: 1471 SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT-------EQLGEGGK 1523
Query: 396 EMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSE-SLRIKEVEHMTRHLE------ESE 448
+ + + ++L++EK + +LE++E SL +E + + LE E E
Sbjct: 1524 NVHELE--------KVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1575
Query: 449 KAMQERVQRLEAARLSLEEELSRVKAAALSERGQAEEEL-IKAKSQARLEEQQ-RLAHLE 506
+ + E+ + +E A+ + + + ++ + +E E L +K K + L E + +L+H
Sbjct: 1576 RKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN 1635
Query: 507 DKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERV 566
R+ A+A QKQV + Q+ + +Q++ R ++L++ +++
Sbjct: 1636 ---RMAAEA----------QKQVKS-LQSLLKDTQIQLDDAVRANDDLKENIAI------ 1675
Query: 567 AEVSRVRVELQEQNGRLQAELAAQEAL---REKAAALERQLKVMASDHREALLDRESENA 623
++ +N LQAEL A+ E++ L Q + S+ + L S+N
Sbjct: 1676 ---------VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL---HSQNT 1723
Query: 624 SLREKLRLREAEIARIRDEEAQRASFLQNA 653
SL + + E+++ +++ E + +NA
Sbjct: 1724 SLINQKKKMESDLTQLQSEVEEAVQECRNA 1753
Score = 63.9 bits (154), Expect = 5e-10
Identities = 76/381 (19%), Positives = 172/381 (45%), Gaps = 53/381 (13%)
Query: 261 DLMETIDKQREEMAKSSRASAARVGQLQEALN-ERHSIINALKAKLQMTEAALALSEQKA 319
++ + ++ EEM ++ R V LQ +L+ E S L+ K +M E L E +
Sbjct: 1573 EIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKM-EGDLNEMEIQL 1631
Query: 320 QDLGELLATAEQEQLSLSQRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDEL 379
+ A A+++ SL Q K+ +++ +A L +++ +N LLQ +++EL
Sbjct: 1632 SHANRMAAEAQKQVKSL-QSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEEL 1690
Query: 380 -------ERKFRCQQEQLFQT-----------------RQEMTSMSAELKMRAIQAEERL 415
ER + +++L +T +++M S +L+ +A +
Sbjct: 1691 RAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQEC 1750
Query: 416 DMEKRRCRQSLEDSESL--RIKEVEHMTRHLEESEKAMQERVQRL-----EAARLSL--- 465
+ + ++++ D+ + +K+ + + HLE +K M++ ++ L EA +++L
Sbjct: 1751 RNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGG 1810
Query: 466 EEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQGACLQ 525
+++L +++A G+ E A+ + E + + E +++ L +E
Sbjct: 1811 KKQLQKLEARVRELEGELE-----AEQKRNAESVKGMRKSERRIKELTYQTEE------- 1858
Query: 526 QKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQEQNGRLQA 585
K+ + Q V +L L+V+ +R+ EE +++ + +++ +V+ EL E R
Sbjct: 1859 DKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAN----TNLSKFRKVQHELDEAEERADI 1914
Query: 586 ELAAQEALREKAAALERQLKV 606
+ LR K+ + + K+
Sbjct: 1915 AESQVNKLRAKSRDIGAKQKM 1935
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 85.9 bits (211), Expect = 1e-16
Identities = 107/450 (23%), Positives = 194/450 (43%), Gaps = 50/450 (11%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQ---REEMAKSSRASAARV 284
+DRL F A K + LR + D+ + + K+ R+E+ K R
Sbjct: 1030 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1089
Query: 285 GQLQEALNERHSIINALKAKLQMTE----AALALSEQKAQDLGELLATAEQEQLSLSQRQ 340
+LQE + E+ L+A+L E AALA +E + +LL + + Q +L++ Q
Sbjct: 1090 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1149
Query: 341 AKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
++L+ E+ + E K RDL E L+ ++++ QQE + QE+T +
Sbjct: 1150 -EDLESERVARTKAE-KQRRDLGEELEA---LRGELEDTLDSTNAQQELRSKREQEVTEL 1204
Query: 401 SAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEA 460
L+ E + ++R Q+L + + LE++ + E
Sbjct: 1205 KKTLEEETRIHEAAVQELRQRHGQALGE-----------LAEQLEQARRGKGA----WEK 1249
Query: 461 ARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQ 520
RL+LE E+S ++A LS A +E + + + L+ Q+ D R A+A ++ Q
Sbjct: 1250 TRLALEAEVSELRAE-LSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQ 1308
Query: 521 GACLQQKQV---VAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQ 577
A + + V + EA+++ +L ++ +L + Q+ L + + ++A SRVR
Sbjct: 1309 RAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVR---- 1364
Query: 578 EQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIA 637
A+ +AA L QL+ A+ A + ++ A L E R +E E
Sbjct: 1365 --------------AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAG 1410
Query: 638 RIR-DEEAQRASFLQNAVLAYVQASPVRTL 666
+ EEA+R + + L A T+
Sbjct: 1411 ALEAGEEARRRAAREAEALTQRLAEKTETV 1440
Score = 82.4 bits (202), Expect = 1e-15
Identities = 104/444 (23%), Positives = 192/444 (43%), Gaps = 48/444 (10%)
Query: 238 QARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSI 297
QAR L K VQ L+++ +++ +L + + EE A+ + A EA R
Sbjct: 880 QARAQELQK-VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETR--- 935
Query: 298 INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQR-QAKELKLEQQEAAERES 356
L A+ Q E ++ E + + E + E+ L Q Q E LE +E A ++
Sbjct: 936 -GRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 994
Query: 357 KLLRDLSAANEKN-----LLLQNQVDELERKFRCQQEQLF----QTRQEMTSMSAELKMR 407
+L + + A K LLL++Q +L ++ + +++L Q +E + + K+R
Sbjct: 995 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLR 1054
Query: 408 AIQAEERLDMEKRRCRQSLEDSESLRIKE-VEHMTRHLEESEKAMQERVQRLEAARLSLE 466
DME R ++ E ++K ++ + L+E Q+R + L A E
Sbjct: 1055 LKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1114
Query: 467 EELSRVKAAALSERGQAEEELIKA--KSQARLEEQQRLAHLEDKLRLLAQARDEAQGACL 524
EEL A A E G A +L+K+ ++QA L E Q E R A+ + G L
Sbjct: 1115 EELQAALARAEDEGG-ARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEEL 1173
Query: 525 Q---------------QKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEV 569
+ Q+++ ++ + V++L +E R E QEL + + + E+
Sbjct: 1174 EALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGEL 1233
Query: 570 S--------------RVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREAL 615
+ + R+ L+ + L+AEL++ + R++ R+L++ + +
Sbjct: 1234 AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRA 1293
Query: 616 LDRESENASLREKLRLREAEIARI 639
D E A EKL+ +AE+ +
Sbjct: 1294 GDGERARAEAAEKLQRAQAELENV 1317
Score = 81.3 bits (199), Expect = 3e-15
Identities = 102/449 (22%), Positives = 195/449 (43%), Gaps = 58/449 (12%)
Query: 234 FQENQARTHVLSKEVQHLREEKSKQFLDLMETIDK-------QREEMAKSSRASAARVGQ 286
++ Q++ + + L EE+ + D++ + +R + + SA RV Q
Sbjct: 786 YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQ 845
Query: 287 LQEA--LNERH----SIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQ 340
A L RH + +K LQ+T L + +AQ+L ++ +Q + + Q
Sbjct: 846 RNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVL-QARAQELQKVQELQQQSAREVGELQ 904
Query: 341 AKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+ +LE++ A +L L A E L + +E + + +QE+ +
Sbjct: 905 GRVAQLEEERA-----RLAEQLRAEAE----LCAEAEETRGRLAAR-------KQELELV 948
Query: 401 SAELKMRAIQAEE---RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQR 457
+EL+ R + EE ++ EK+R +Q +++ E+ ++ E + L+ + + ++++
Sbjct: 949 VSELEARVGEEEECSRQMQTEKKRLQQHIQELEA-HLEAEEGARQKLQLEKVTTEAKMKK 1007
Query: 458 LEAARLSLEEELSRV---------KAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDK 508
E L LE++ S++ + A S + EEE +K+ ++ RL+ + +A +ED+
Sbjct: 1008 FEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDR 1067
Query: 509 LRLLAQARDEAQ-------GACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLK 561
LR + R E + G + ++ + E Q R +L Q L R+ EELQ L+
Sbjct: 1068 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ---LGRKEEELQAALARA 1124
Query: 562 DQERVAEVSRVRV--ELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHR---EALL 616
+ E A ++ E Q Q +L ++ R KA R L R E L
Sbjct: 1125 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1184
Query: 617 DRESENASLREKLRLREAEIARIRDEEAQ 645
D + LR K E+ + +EE +
Sbjct: 1185 DSTNAQQELRSKREQEVTELKKTLEEETR 1213
Score = 78.2 bits (191), Expect = 2e-14
Identities = 105/470 (22%), Positives = 199/470 (42%), Gaps = 74/470 (15%)
Query: 232 TTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
T QE + R L ++Q ++ ++ R E A+ + + A + + AL
Sbjct: 1270 TARQEGEQRRRRLELQLQEVQGRAGDG--------ERARAEAAEKLQRAQAELENVSGAL 1321
Query: 292 NERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQR------QAKELK 345
NE S L +L TEA L D ELL + +L+L R +A L+
Sbjct: 1322 NEAESKTIRLSKELSSTEAQL-------HDAQELLQEETRAKLALGSRVRAMEAEAAGLR 1374
Query: 346 LEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELK 405
+ +E A + R+L A + + + +E +E + +E +++ L
Sbjct: 1375 EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLA 1434
Query: 406 MRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSL 465
+ + +RL+ +RR +Q L+D+ ++ +++ + LE+ ++ + + +AA L
Sbjct: 1435 EKT-ETVDRLERGRRRLQQELDDA-TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1492
Query: 466 EEELSRVKA-------------AALSERGQAEEELIKAKSQARLEEQQRLA--------- 503
EE R +A AL E +A EEL + R E + L+
Sbjct: 1493 VEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSV 1552
Query: 504 -HLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLE-ELQ------ 555
LE R+ QA ++ + + + + A+ +L + V+ L+ + E +LQ
Sbjct: 1553 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG 1612
Query: 556 --QELSLKDQERVAEVSR------------VRVELQEQNGRLQAELAAQEALREKAA--- 598
+ L Q R AEV R R +L+ + L+A++A+ +E+A
Sbjct: 1613 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1672
Query: 599 -ALERQLKVMASDHREALLDRE---SENASLREKLRLREAEIARIRDEEA 644
++ Q+K + + E RE S+N ++L+ EAE+ R+++E A
Sbjct: 1673 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELA 1722
Score = 77.8 bits (190), Expect = 3e-14
Identities = 159/728 (21%), Positives = 283/728 (38%), Gaps = 135/728 (18%)
Query: 20 QEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSDC--MLSEEGATL 77
+ A + +L R + +L S + + L +E TE L D +L EE
Sbjct: 1297 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1356
Query: 78 LLRGLCANTVLRFLDLKGNNLR------AAGAEALGKLLQQNKSIQSLTLEWNSLGTWDD 131
L G + +R ++ + LR AA E G+ LQ + Q+ EW ++
Sbjct: 1357 LALG----SRVRAMEAEAAGLREQLEEEAAARERAGRELQ---TAQAQLSEWRRRQE-EE 1408
Query: 132 AFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRA 191
A A G A A + + +++ K E + +G LQQ +L + L R
Sbjct: 1409 AGALEAGEEARRRAAREAEALTQRLAEK-TETVDRLERGRRRLQQ-ELDDATMDLEQQRQ 1466
Query: 192 LMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSK---EV 248
L++ L + + LA VLRAVE+ + +E +AR L++ E
Sbjct: 1467 LVSTLEKKQRKFDQLLAEEKAA--VLRAVEERERAEAEG----REREARALSLTRALEEE 1520
Query: 249 QHLREEKSKQ----------FLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSII 298
Q REE +Q L + + K E+ ++ R + L+ + E +
Sbjct: 1521 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1580
Query: 299 NALK-AKLQMTEAALALSEQKAQDL--------------------GELLATAEQEQLSLS 337
A + AKL++ AL Q +DL E+ E++Q +L+
Sbjct: 1581 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1640
Query: 338 QRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKF---RCQQEQLFQTR 394
K+L+ E +E + + + A ++ +Q Q+ EL R+ R +E++F
Sbjct: 1641 VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQN 1700
Query: 395 QEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESL---------------------- 432
+E L+ ++ +E L R RQ+ +D + +
Sbjct: 1701 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLE 1760
Query: 433 -RIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVK---AAALSERGQAEEELI 488
R+ ++E + + + + +R ++L SL ELS + A A S R Q E ++
Sbjct: 1761 GRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1820
Query: 489 KAKSQ-------ARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+ + + AR + +A LE KL + ++ + ++V A+ R+ ++
Sbjct: 1821 ELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVV 1880
Query: 542 LQVEG---------------------LRRRLEELQQELSLKDQERVAEVSRVRVELQEQN 580
LQVE L+R+LEE ++E S Q
Sbjct: 1881 LQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEAS---------------RAQAGR 1925
Query: 581 GRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIR 640
RLQ EL E + E A ++ R++ + + R L + ++R+ RL E +
Sbjct: 1926 RRLQREL---EDVTESAESMNREVTTLRNRLRRGPLTFTTR--TVRQVFRLEEGVASDEE 1980
Query: 641 DEEAQRAS 648
EEAQ S
Sbjct: 1981 AEEAQPGS 1988
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 85.9 bits (211), Expect = 1e-16
Identities = 107/450 (23%), Positives = 194/450 (43%), Gaps = 50/450 (11%)
Query: 228 QDRLTTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQ---REEMAKSSRASAARV 284
+DRL F A K + LR + D+ + + K+ R+E+ K R
Sbjct: 1022 EDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGES 1081
Query: 285 GQLQEALNERHSIINALKAKLQMTE----AALALSEQKAQDLGELLATAEQEQLSLSQRQ 340
+LQE + E+ L+A+L E AALA +E + +LL + + Q +L++ Q
Sbjct: 1082 SELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQ 1141
Query: 341 AKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
++L+ E+ + E K RDL E L+ ++++ QQE + QE+T +
Sbjct: 1142 -EDLESERVARTKAE-KQRRDLGEELEA---LRGELEDTLDSTNAQQELRSKREQEVTEL 1196
Query: 401 SAELKMRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEA 460
L+ E + ++R Q+L + + LE++ + E
Sbjct: 1197 KKTLEEETRIHEAAVQELRQRHGQALGE-----------LAEQLEQARRGKGA----WEK 1241
Query: 461 ARLSLEEELSRVKAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDKLRLLAQARDEAQ 520
RL+LE E+S ++A LS A +E + + + L+ Q+ D R A+A ++ Q
Sbjct: 1242 TRLALEAEVSELRAE-LSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQ 1300
Query: 521 GACLQQKQV---VAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEVSRVRVELQ 577
A + + V + EA+++ +L ++ +L + Q+ L + + ++A SRVR
Sbjct: 1301 RAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVR---- 1356
Query: 578 EQNGRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIA 637
A+ +AA L QL+ A+ A + ++ A L E R +E E
Sbjct: 1357 --------------AMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAG 1402
Query: 638 RIR-DEEAQRASFLQNAVLAYVQASPVRTL 666
+ EEA+R + + L A T+
Sbjct: 1403 ALEAGEEARRRAAREAEALTQRLAEKTETV 1432
Score = 82.4 bits (202), Expect = 1e-15
Identities = 104/444 (23%), Positives = 192/444 (43%), Gaps = 48/444 (10%)
Query: 238 QARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSI 297
QAR L K VQ L+++ +++ +L + + EE A+ + A EA R
Sbjct: 872 QARAQELQK-VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETR--- 927
Query: 298 INALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQR-QAKELKLEQQEAAERES 356
L A+ Q E ++ E + + E + E+ L Q Q E LE +E A ++
Sbjct: 928 -GRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKL 986
Query: 357 KLLRDLSAANEKN-----LLLQNQVDELERKFRCQQEQLF----QTRQEMTSMSAELKMR 407
+L + + A K LLL++Q +L ++ + +++L Q +E + + K+R
Sbjct: 987 QLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLR 1046
Query: 408 AIQAEERLDMEKRRCRQSLEDSESLRIKE-VEHMTRHLEESEKAMQERVQRLEAARLSLE 466
DME R ++ E ++K ++ + L+E Q+R + L A E
Sbjct: 1047 LKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKE 1106
Query: 467 EELSRVKAAALSERGQAEEELIKA--KSQARLEEQQRLAHLEDKLRLLAQARDEAQGACL 524
EEL A A E G A +L+K+ ++QA L E Q E R A+ + G L
Sbjct: 1107 EELQAALARAEDEGG-ARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEEL 1165
Query: 525 Q---------------QKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLKDQERVAEV 569
+ Q+++ ++ + V++L +E R E QEL + + + E+
Sbjct: 1166 EALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGEL 1225
Query: 570 S--------------RVRVELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHREAL 615
+ + R+ L+ + L+AEL++ + R++ R+L++ + +
Sbjct: 1226 AEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRA 1285
Query: 616 LDRESENASLREKLRLREAEIARI 639
D E A EKL+ +AE+ +
Sbjct: 1286 GDGERARAEAAEKLQRAQAELENV 1309
Score = 81.3 bits (199), Expect = 3e-15
Identities = 102/449 (22%), Positives = 195/449 (43%), Gaps = 58/449 (12%)
Query: 234 FQENQARTHVLSKEVQHLREEKSKQFLDLMETIDK-------QREEMAKSSRASAARVGQ 286
++ Q++ + + L EE+ + D++ + +R + + SA RV Q
Sbjct: 778 YRVGQSKIFFRAGVLAQLEEERDLKVTDIIVSFQAAARGYLARRAFQKRQQQQSALRVMQ 837
Query: 287 LQEA--LNERH----SIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQRQ 340
A L RH + +K LQ+T L + +AQ+L ++ +Q + + Q
Sbjct: 838 RNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVL-QARAQELQKVQELQQQSAREVGELQ 896
Query: 341 AKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSM 400
+ +LE++ A +L L A E L + +E + + +QE+ +
Sbjct: 897 GRVAQLEEERA-----RLAEQLRAEAE----LCAEAEETRGRLAAR-------KQELELV 940
Query: 401 SAELKMRAIQAEE---RLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQR 457
+EL+ R + EE ++ EK+R +Q +++ E+ ++ E + L+ + + ++++
Sbjct: 941 VSELEARVGEEEECSRQMQTEKKRLQQHIQELEA-HLEAEEGARQKLQLEKVTTEAKMKK 999
Query: 458 LEAARLSLEEELSRV---------KAAALSERGQAEEELIKAKSQARLEEQQRLAHLEDK 508
E L LE++ S++ + A S + EEE +K+ ++ RL+ + +A +ED+
Sbjct: 1000 FEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDR 1059
Query: 509 LRLLAQARDEAQ-------GACLQQKQVVAEAQTRVSQLGLQVEGLRRRLEELQQELSLK 561
LR + R E + G + ++ + E Q R +L Q L R+ EELQ L+
Sbjct: 1060 LRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ---LGRKEEELQAALARA 1116
Query: 562 DQERVAEVSRVRV--ELQEQNGRLQAELAAQEALREKAAALERQLKVMASDHR---EALL 616
+ E A ++ E Q Q +L ++ R KA R L R E L
Sbjct: 1117 EDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTL 1176
Query: 617 DRESENASLREKLRLREAEIARIRDEEAQ 645
D + LR K E+ + +EE +
Sbjct: 1177 DSTNAQQELRSKREQEVTELKKTLEEETR 1205
Score = 78.2 bits (191), Expect = 2e-14
Identities = 105/470 (22%), Positives = 199/470 (42%), Gaps = 74/470 (15%)
Query: 232 TTFQENQARTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEAL 291
T QE + R L ++Q ++ ++ R E A+ + + A + + AL
Sbjct: 1262 TARQEGEQRRRRLELQLQEVQGRAGDG--------ERARAEAAEKLQRAQAELENVSGAL 1313
Query: 292 NERHSIINALKAKLQMTEAALALSEQKAQDLGELLATAEQEQLSLSQR------QAKELK 345
NE S L +L TEA L D ELL + +L+L R +A L+
Sbjct: 1314 NEAESKTIRLSKELSSTEAQL-------HDAQELLQEETRAKLALGSRVRAMEAEAAGLR 1366
Query: 346 LEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTSMSAELK 405
+ +E A + R+L A + + + +E +E + +E +++ L
Sbjct: 1367 EQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLA 1426
Query: 406 MRAIQAEERLDMEKRRCRQSLEDSESLRIKEVEHMTRHLEESEKAMQERVQRLEAARLSL 465
+ + +RL+ +RR +Q L+D+ ++ +++ + LE+ ++ + + +AA L
Sbjct: 1427 EKT-ETVDRLERGRRRLQQELDDA-TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA 1484
Query: 466 EEELSRVKA-------------AALSERGQAEEELIKAKSQARLEEQQRLA--------- 503
EE R +A AL E +A EEL + R E + L+
Sbjct: 1485 VEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSV 1544
Query: 504 -HLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLGLQVEGLRRRLE-ELQ------ 555
LE R+ QA ++ + + + + A+ +L + V+ L+ + E +LQ
Sbjct: 1545 HELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAG 1604
Query: 556 --QELSLKDQERVAEVSR------------VRVELQEQNGRLQAELAAQEALREKAA--- 598
+ L Q R AEV R R +L+ + L+A++A+ +E+A
Sbjct: 1605 EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQL 1664
Query: 599 -ALERQLKVMASDHREALLDRE---SENASLREKLRLREAEIARIRDEEA 644
++ Q+K + + E RE S+N ++L+ EAE+ R+++E A
Sbjct: 1665 RKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELA 1714
Score = 77.8 bits (190), Expect = 3e-14
Identities = 159/728 (21%), Positives = 283/728 (38%), Gaps = 135/728 (18%)
Query: 20 QEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSDC--MLSEEGATL 77
+ A + +L R + +L S + + L +E TE L D +L EE
Sbjct: 1289 ERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAK 1348
Query: 78 LLRGLCANTVLRFLDLKGNNLR------AAGAEALGKLLQQNKSIQSLTLEWNSLGTWDD 131
L G + +R ++ + LR AA E G+ LQ + Q+ EW ++
Sbjct: 1349 LALG----SRVRAMEAEAAGLREQLEEEAAARERAGRELQ---TAQAQLSEWRRRQE-EE 1400
Query: 132 AFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGLLGGRA 191
A A G A A + + +++ K E + +G LQQ +L + L R
Sbjct: 1401 AGALEAGEEARRRAAREAEALTQRLAEK-TETVDRLERGRRRLQQ-ELDDATMDLEQQRQ 1458
Query: 192 LMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRLTTFQENQARTHVLSK---EV 248
L++ L + + LA VLRAVE+ + +E +AR L++ E
Sbjct: 1459 LVSTLEKKQRKFDQLLAEEKAA--VLRAVEERERAEAEG----REREARALSLTRALEEE 1512
Query: 249 QHLREEKSKQ----------FLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSII 298
Q REE +Q L + + K E+ ++ R + L+ + E +
Sbjct: 1513 QEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDEL 1572
Query: 299 NALK-AKLQMTEAALALSEQKAQDL--------------------GELLATAEQEQLSLS 337
A + AKL++ AL Q +DL E+ E++Q +L+
Sbjct: 1573 TAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLA 1632
Query: 338 QRQAKELKLEQQEAAERESKLLRDLSAANEKNLLLQNQVDELERKF---RCQQEQLFQTR 394
K+L+ E +E + + + A ++ +Q Q+ EL R+ R +E++F
Sbjct: 1633 VAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQN 1692
Query: 395 QEMTSMSAELKMRAIQAEERLDMEKRRCRQSLEDSESL---------------------- 432
+E L+ ++ +E L R RQ+ +D + +
Sbjct: 1693 RESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLE 1752
Query: 433 -RIKEVEHMTRHLEESEKAMQERVQRLEAARLSLEEELSRVK---AAALSERGQAEEELI 488
R+ ++E + + + + +R ++L SL ELS + A A S R Q E ++
Sbjct: 1753 GRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQ 1812
Query: 489 KAKSQ-------ARLEEQQRLAHLEDKLRLLAQARDEAQGACLQQKQVVAEAQTRVSQLG 541
+ + + AR + +A LE KL + ++ + ++V A+ R+ ++
Sbjct: 1813 ELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVV 1872
Query: 542 LQVEG---------------------LRRRLEELQQELSLKDQERVAEVSRVRVELQEQN 580
LQVE L+R+LEE ++E S Q
Sbjct: 1873 LQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEAS---------------RAQAGR 1917
Query: 581 GRLQAELAAQEALREKAAALERQLKVMASDHREALLDRESENASLREKLRLREAEIARIR 640
RLQ EL E + E A ++ R++ + + R L + ++R+ RL E +
Sbjct: 1918 RRLQREL---EDVTESAESMNREVTTLRNRLRRGPLTFTTR--TVRQVFRLEEGVASDEE 1972
Query: 641 DEEAQRAS 648
EEAQ S
Sbjct: 1973 AEEAQPGS 1980
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.127 0.333
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,617,529
Number of Sequences: 37866
Number of extensions: 871036
Number of successful extensions: 17101
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 472
Number of HSP's successfully gapped in prelim test: 1203
Number of HSP's that attempted gapping in prelim test: 5328
Number of HSP's gapped (non-prelim): 5380
length of query: 670
length of database: 18,247,518
effective HSP length: 109
effective length of query: 561
effective length of database: 14,120,124
effective search space: 7921389564
effective search space used: 7921389564
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.