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Search of human proteins with 214010220
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
(738 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] 1517 0.0
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens] 1134 0.0
gi|157388902 semaphorin 4C [Homo sapiens] 469 e-132
gi|39777610 semaphorin 4B precursor [Homo sapiens] 456 e-128
gi|39777608 semaphorin 4B precursor [Homo sapiens] 456 e-128
gi|28872814 semaphorin 4G [Homo sapiens] 411 e-114
gi|19923279 semaphorin W [Homo sapiens] 379 e-105
gi|21361914 semaphorin B [Homo sapiens] 376 e-104
gi|5174673 semaphorin 3A precursor [Homo sapiens] 342 7e-94
gi|5454048 semaphorin 3C [Homo sapiens] 331 2e-90
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens] 323 5e-88
gi|41406086 semaphorin 3D [Homo sapiens] 322 6e-88
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens] 321 2e-87
gi|6912650 semaphorin 3E [Homo sapiens] 309 7e-84
gi|188497703 semaphorin 3F [Homo sapiens] 299 7e-81
gi|9910362 semaphorin sem2 [Homo sapiens] 297 2e-80
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens] 281 2e-75
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens] 281 2e-75
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens] 281 2e-75
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens] 281 2e-75
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens] 281 2e-75
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas... 268 2e-71
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 261 1e-69
gi|147904700 semaphorin 5A [Homo sapiens] 249 8e-66
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens] 248 1e-65
gi|19718780 semaphorin 6B precursor [Homo sapiens] 234 2e-61
gi|16306552 semaphorin Y [Homo sapiens] 234 2e-61
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens] 190 5e-48
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens] 190 5e-48
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens] 166 9e-41
>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
Length = 738
Score = 1517 bits (3928), Expect = 0.0
Identities = 738/738 (100%), Positives = 738/738 (100%)
Query: 1 MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD 60
MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD
Sbjct: 1 MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD 60
Query: 61 TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA 120
TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA
Sbjct: 61 TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA 120
Query: 121 TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN 180
TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN
Sbjct: 121 TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN 180
Query: 181 FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV 240
FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV
Sbjct: 181 FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV 240
Query: 241 EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR 300
EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR
Sbjct: 241 EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR 300
Query: 301 SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG 360
SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG
Sbjct: 301 SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG 360
Query: 361 PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY 420
PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY
Sbjct: 361 PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY 420
Query: 421 TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS 480
TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS
Sbjct: 421 TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS 480
Query: 481 KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR 540
KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR
Sbjct: 481 KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR 540
Query: 541 GLIQEMSGDASVCPASSPKPLPPPGSSSLSCLGHVGDRRLSSPWTPWPASGAGPDSSSRV 600
GLIQEMSGDASVCPASSPKPLPPPGSSSLSCLGHVGDRRLSSPWTPWPASGAGPDSSSRV
Sbjct: 541 GLIQEMSGDASVCPASSPKPLPPPGSSSLSCLGHVGDRRLSSPWTPWPASGAGPDSSSRV 600
Query: 601 SLLPPFLSDQAQHVHALGNFYLFCQATGPADIRFVWEKNGRALETCVPVQTHALPDGRAH 660
SLLPPFLSDQAQHVHALGNFYLFCQATGPADIRFVWEKNGRALETCVPVQTHALPDGRAH
Sbjct: 601 SLLPPFLSDQAQHVHALGNFYLFCQATGPADIRFVWEKNGRALETCVPVQTHALPDGRAH 660
Query: 661 ALSWLQDAIRESAEYRCSVLSSAGNKTSKVQVAVMRPEVTHQERWTRELSAWRAVAGEHD 720
ALSWLQDAIRESAEYRCSVLSSAGNKTSKVQVAVMRPEVTHQERWTRELSAWRAVAGEHD
Sbjct: 661 ALSWLQDAIRESAEYRCSVLSSAGNKTSKVQVAVMRPEVTHQERWTRELSAWRAVAGEHD 720
Query: 721 RMMQSWRKAWESCSKDTL 738
RMMQSWRKAWESCSKDTL
Sbjct: 721 RMMQSWRKAWESCSKDTL 738
>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
Length = 862
Score = 1134 bits (2934), Expect = 0.0
Identities = 555/557 (99%), Positives = 555/557 (99%)
Query: 1 MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD 60
MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD
Sbjct: 1 MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD 60
Query: 61 TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA 120
TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA
Sbjct: 61 TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA 120
Query: 121 TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN 180
TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN
Sbjct: 121 TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN 180
Query: 181 FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV 240
FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV
Sbjct: 181 FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV 240
Query: 241 EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR 300
EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR
Sbjct: 241 EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR 300
Query: 301 SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG 360
SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG
Sbjct: 301 SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG 360
Query: 361 PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY 420
PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY
Sbjct: 361 PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY 420
Query: 421 TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS 480
TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS
Sbjct: 421 TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS 480
Query: 481 KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR 540
KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR
Sbjct: 481 KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR 540
Query: 541 GLIQEMSGDASVCPASS 557
GLIQEMSGDASVCP S
Sbjct: 541 GLIQEMSGDASVCPDKS 557
>gi|157388902 semaphorin 4C [Homo sapiens]
Length = 833
Score = 469 bits (1208), Expect = e-132
Identities = 260/573 (45%), Positives = 350/573 (61%), Gaps = 25/573 (4%)
Query: 27 IPRITWEHREVHLV--QFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHE 84
+PR T E+ V +F + I ++ L L+E LY+GAREA+FA + + E Q
Sbjct: 28 VPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFS-MEALELQGA 86
Query: 85 VYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFK 144
+ W+ +KK +C +KGK+ QTEC N+IR LQP +A+ LYVCGT AFQP C ++N+ +F
Sbjct: 87 ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFT 146
Query: 145 FL-GKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSS-HSPLRTEYA 202
G+ EDGKG+CP+DPA + ++VDGELYS T NFLG+EPII RN H ++TEY
Sbjct: 147 LEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYL 206
Query: 203 IPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQG 262
WLNEP FV + + +S S G+DD+VYFFF E +VE + ++ R+ARVCKGD G
Sbjct: 207 AFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMG 266
Query: 263 GLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGL 322
G RTLQ+KWT+FLKARL CS P+ L FN L+ + L+ F+ +F Q ++ L
Sbjct: 267 GARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYL 326
Query: 323 SAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTS 382
SA+C Y L + VF G Y + + KW RY PVP PRPG+CI++ R YTS
Sbjct: 327 SAICEYQLEEIQRVF-EGPYKE---YHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTS 382
Query: 383 SLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVS 442
SL LPD L FVK HPLM++ V P +RP L+KK N+T +V DR LDG Y V+F+
Sbjct: 383 SLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIG 442
Query: 443 TDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAF 502
T G L KA+SL VH+IEE QLF D EP+++L+LS K + ++AGS S +VQ P+A
Sbjct: 443 TGDGWLLKAVSLGPWVHLIEELQLF-DQEPMRSLVLSQSK--KLLFAGSRSQLVQLPVAD 499
Query: 503 CGKHGTCEDCVLARDPYCAWSPPTATCVAL----------HQTESPSRGLIQEMSGDASV 552
C K+ +C DCVLARDPYCAWS T+ CVA+ H S + G I + G V
Sbjct: 500 CMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSG-ICNLRGSKKV 558
Query: 553 CPASSPKPLPPPGSSSLSCLGHVGDRRLSSPWT 585
P +PK + + L H+ + WT
Sbjct: 559 RP--TPKNITVVAGTDLVLPCHLSSNLAHARWT 589
>gi|39777610 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 456 bits (1173), Expect = e-128
Identities = 255/570 (44%), Positives = 355/570 (62%), Gaps = 29/570 (5%)
Query: 6 PIRGLLMALAVMFGTAMAFAPIPRITWE--HREVHLVQFHEPDIYNYSALLLSEDKDTLY 63
P+ LL+ L ++ +A PRI+ E ++F I NY+ALLLS D TLY
Sbjct: 24 PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLY 83
Query: 64 IGAREAVFAVNALNIS----EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS 119
+GAREA+FA+++ N+S + E+ W +KK +C+ KGK Q +C NYI++L PLS
Sbjct: 84 VGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLS 142
Query: 120 ATSLYVCGTNAFQPACDHLNLTSFKFLGKN------EDGKGRCPFDPAHSYTSVMVDGEL 173
+ L+ CGT AF P C ++N+ +F EDGKGRCPFDP T+++VDGEL
Sbjct: 143 GSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGEL 202
Query: 174 YSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYF 233
Y+GT +F G++P ISR+ S P +TE ++ WL +P+FV + I +S S G+DD++YF
Sbjct: 203 YTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYF 262
Query: 234 FFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVL 293
FF+E E+EF ++ RIAR+CKGD+GG R LQ++WTSFLKA+L+CSRPD G FNVL
Sbjct: 263 FFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVL 322
Query: 294 RDVFVLR-SP-GLKVPVFYALFTPQLN--NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349
+DVF L SP + +FY +FT Q + SAVC + + + VFS G Y + V
Sbjct: 323 QDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS-GLYKE---VN 378
Query: 350 QSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409
+ +W PVP PRPGACI + AR SSL LPD+ L F+KDH LMD V +
Sbjct: 379 RETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---S 435
Query: 410 RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQD 469
R L++ Y ++ V R L T YDV+F+ T G LHKA+S+ VHIIEE Q+F
Sbjct: 436 RMLLLQPQARYQRVAVHRVPGLHHT-YDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSS 494
Query: 470 FEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATC 529
+PVQ LLL + +G +YA S+SGVVQ P+A C + +C DC+LARDPYCAWS +
Sbjct: 495 GQPVQNLLLDTHRG--LLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWSGSSCKH 552
Query: 530 VALHQTESPSRGLIQEMSGDAS--VCPASS 557
V+L+Q + +R IQ++ G ++ +C ASS
Sbjct: 553 VSLYQPQLATRPWIQDIEGASAKDLCSASS 582
>gi|39777608 semaphorin 4B precursor [Homo sapiens]
Length = 837
Score = 456 bits (1173), Expect = e-128
Identities = 255/570 (44%), Positives = 355/570 (62%), Gaps = 29/570 (5%)
Query: 6 PIRGLLMALAVMFGTAMAFAPIPRITWE--HREVHLVQFHEPDIYNYSALLLSEDKDTLY 63
P+ LL+ L ++ +A PRI+ E ++F I NY+ALLLS D TLY
Sbjct: 24 PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLY 83
Query: 64 IGAREAVFAVNALNIS----EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS 119
+GAREA+FA+++ N+S + E+ W +KK +C+ KGK Q +C NYI++L PLS
Sbjct: 84 VGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLS 142
Query: 120 ATSLYVCGTNAFQPACDHLNLTSFKFLGKN------EDGKGRCPFDPAHSYTSVMVDGEL 173
+ L+ CGT AF P C ++N+ +F EDGKGRCPFDP T+++VDGEL
Sbjct: 143 GSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGEL 202
Query: 174 YSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYF 233
Y+GT +F G++P ISR+ S P +TE ++ WL +P+FV + I +S S G+DD++YF
Sbjct: 203 YTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYF 262
Query: 234 FFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVL 293
FF+E E+EF ++ RIAR+CKGD+GG R LQ++WTSFLKA+L+CSRPD G FNVL
Sbjct: 263 FFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVL 322
Query: 294 RDVFVLR-SP-GLKVPVFYALFTPQLN--NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349
+DVF L SP + +FY +FT Q + SAVC + + + VFS G Y + V
Sbjct: 323 QDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS-GLYKE---VN 378
Query: 350 QSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409
+ +W PVP PRPGACI + AR SSL LPD+ L F+KDH LMD V +
Sbjct: 379 RETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---S 435
Query: 410 RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQD 469
R L++ Y ++ V R L T YDV+F+ T G LHKA+S+ VHIIEE Q+F
Sbjct: 436 RMLLLQPQARYQRVAVHRVPGLHHT-YDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSS 494
Query: 470 FEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATC 529
+PVQ LLL + +G +YA S+SGVVQ P+A C + +C DC+LARDPYCAWS +
Sbjct: 495 GQPVQNLLLDTHRG--LLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWSGSSCKH 552
Query: 530 VALHQTESPSRGLIQEMSGDAS--VCPASS 557
V+L+Q + +R IQ++ G ++ +C ASS
Sbjct: 553 VSLYQPQLATRPWIQDIEGASAKDLCSASS 582
>gi|28872814 semaphorin 4G [Homo sapiens]
Length = 843
Score = 411 bits (1057), Expect = e-114
Identities = 227/551 (41%), Positives = 327/551 (59%), Gaps = 25/551 (4%)
Query: 28 PRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQH-EVY 86
PR+T + E+ + + NYS LLL E L +GAR A+F+++A +I + H E++
Sbjct: 34 PRMTIPYEELSGTRHFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDIGDGAHKEIH 93
Query: 87 WKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFL 146
W+ S + ++KC +KGK+ QTEC N++R LQ L++T LY CGT+AFQP C ++ +F
Sbjct: 94 WEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAEAFTLP 153
Query: 147 GKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYA-IPW 205
E+GK +CP+DPA +T +++DG LY+ T Y F S P I R+ LRTE + W
Sbjct: 154 TSFEEGKEKCPYDPARGFTGLIIDGGLYTATRYEF-RSIPDIRRSRHPHSLRTEETPMHW 212
Query: 206 LNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVE------YEFVFRVLIPRIARVCKG 259
LN+ FVF+ ++R+S S G+DD+VY+FFTE + E + + R+ARVCKG
Sbjct: 213 LNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKG 272
Query: 260 DQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFT--PQL 317
D GG + LQKKWTSFLKARLIC P ++ LR V L + FYA FT Q
Sbjct: 273 DLGGKKILQKKWTSFLKARLICHIP----LYETLRGVCSLDAETSSRTHFYAAFTLSTQW 328
Query: 318 NNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARA 377
+ SA+C Y+L+ + VF+ G YM+ + +W RY G VP+PRPG+CI R+
Sbjct: 329 KTLEASAICRYDLAEIQAVFA-GPYME---YQDGSRRWGRYEGGVPEPRPGSCITDSLRS 384
Query: 378 ANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYD 437
Y SS +LP L FVK HPLM V P RP L+K+++ YT + G YD
Sbjct: 385 QGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTPAGPTYD 444
Query: 438 VMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQ 497
++F+ T G +HKA+ L +HIIEETQ+F++ + V+ L++S + + +Y G+ SGV+Q
Sbjct: 445 LLFLGTADGWIHKAVVLGSGMHIIEETQVFRESQSVENLVISLLQHS--LYVGAPSGVIQ 502
Query: 498 APLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRG----LIQEMSGDASVC 553
PL+ C ++ +C DC+LARDPYC W P T C A + S+G LIQ++ C
Sbjct: 503 LPLSSCSRYRSCYDCILARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDIERGNRGC 562
Query: 554 PASSPKPLPPP 564
+S PPP
Sbjct: 563 ESSRDTGPPPP 573
>gi|19923279 semaphorin W [Homo sapiens]
Length = 770
Score = 379 bits (972), Expect = e-105
Identities = 210/553 (37%), Positives = 320/553 (57%), Gaps = 20/553 (3%)
Query: 11 LMALAVMFGTAMAFAP--IPRITWEHREVH--LVQFHEPDIYNYSALLLSEDKDTLYIGA 66
L+ LAV+ G P +PR + E L +F P YNYS LL+ TLY+GA
Sbjct: 22 LLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGA 81
Query: 67 REAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVC 126
R+ +FA++ E+ + W V E + C +KGK K+ EC N++++L +A+ L C
Sbjct: 82 RDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGK-KEDECHNFVQILAIANASHLLTC 140
Query: 127 GTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEP 186
GT AF P C ++++ F+ + + E G+G+CPF+PA +VM G LY+ T N+LG+EP
Sbjct: 141 GTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEP 200
Query: 187 IISRNSSHSP--LRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEF 244
II+R + +RT+ WLN P+FV A + + + DD +YFFFTE S ++
Sbjct: 201 IITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDS 260
Query: 245 VFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSP-G 303
R+ +PR+ARVC GD GG +TLQ++WT+FLKA L+C P+ G +VL+DV VLR G
Sbjct: 261 YERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELG 320
Query: 304 LKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVP 363
P+FY +F+ Q +SAVCA+ V + G + + + + VP
Sbjct: 321 AGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLN-GPFRELK--HDCNRGLPVVDNDVP 377
Query: 364 KPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQI 423
+PRPG CI + + ++ SSL+LPD+ L F++DHPLMD V P D P L+ D Y ++
Sbjct: 378 QPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRV 437
Query: 424 VVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKG 483
V R +L G YDV+++ T+ G LH+A+ + + ++E+ LF + +PV+ + K
Sbjct: 438 VAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENM----KLY 493
Query: 484 NRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLI 543
+ ++ GS + V Q CG+ +C +C+LA+DP CAWS CVA H E RGL+
Sbjct: 494 HSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVA-HAGE--HRGLV 550
Query: 544 QEM-SGD-ASVCP 554
Q++ S D +S+CP
Sbjct: 551 QDIESADVSSLCP 563
>gi|21361914 semaphorin B [Homo sapiens]
Length = 761
Score = 376 bits (965), Expect = e-104
Identities = 221/522 (42%), Positives = 309/522 (59%), Gaps = 48/522 (9%)
Query: 26 PIPRITW----EHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALN--IS 79
P+PR+ + E R + FH+ + ++ LLLS D +TLY+GAREA+ A++ + +
Sbjct: 38 PMPRVRYYAGDERRALSF--FHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVP 95
Query: 80 EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLN 139
++ + W S+ KK++CA K KS +T+C N+IRVL + T LY CGT AF PAC +
Sbjct: 96 RLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIE 155
Query: 140 LTSFKFLGKNED----GKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHS 195
L L +ED GKG+ PFDPAH +T+V+VDG LYSGT NFLGSEPI+ R
Sbjct: 156 LQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQ 215
Query: 196 P-LRTEYAIPWLN-EPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRI 253
P L+T+ + WL+ + SFV A P + VYFFF E + E++F R+ R+
Sbjct: 216 PVLKTDNFLRWLHHDASFVAA-----IPST-----QVVYFFFEETASEFDFFERLHTSRV 265
Query: 254 ARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALF 313
ARVCK D GG + LQKKWT+FLKA+L+C++P L FNV+R +L + P YA+F
Sbjct: 266 ARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQ-LPFNVIRHAVLLPADSPTAPHIYAVF 324
Query: 314 TP--QLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACI 371
T Q+ SAVCA++L E VF GKY + + + ++W Y GP PRPG+C
Sbjct: 325 TSQWQVGGTRSSAVCAFSLLDIERVFK-GKYKE---LNKETSRWTTYRGPETNPRPGSCS 380
Query: 372 DSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQAL 431
+ DK L F+KDH LMD+ V P L+K V YT++ V+ Q L
Sbjct: 381 VGPS-----------SDKALTFMKDHFLMDEQVV---GTPLLVKSGVEYTRLAVETAQGL 426
Query: 432 DGTVYDVMFVSTDRGALHKA-ISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAG 490
DG + VM++ T G+LHKA +S + + H++EE QLF D EPV+ L L+ +G V+ G
Sbjct: 427 DGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQG--AVFVG 484
Query: 491 SNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVAL 532
+ GV + P A C + +C DCVLARDP+CAW P + TC L
Sbjct: 485 FSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLL 526
>gi|5174673 semaphorin 3A precursor [Homo sapiens]
Length = 771
Score = 342 bits (877), Expect = 7e-94
Identities = 205/522 (39%), Positives = 304/522 (58%), Gaps = 39/522 (7%)
Query: 27 IPRITWEHREV----HLVQFHE-PDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEK 81
+PR+ ++E+ +++ F+ + +Y LL E++ LY+GA++ +F+ + +NI +
Sbjct: 29 VPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDF 88
Query: 82 QHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNL- 140
Q ++ W VS ++ +C GK EC N+I+VL+ + T LY CGT AF P C ++ +
Sbjct: 89 Q-KIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIG 147
Query: 141 -----TSFKFLGKN-EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SS 193
FK + E+G+G+ P+DP S+++DGELYSGT+ +F+G + I R
Sbjct: 148 HHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGH 207
Query: 194 HSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPR 252
H P+RTE + WLN+P F+ A +I +S D+P EDD+VYFFF E +++ E + R
Sbjct: 208 HHPIRTEQHDSRWLNDPKFISAHLISES-DNP--EDDKVYFFFRENAIDGEHSGKATHAR 264
Query: 253 IARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVF 309
I ++CK D GG R+L KWT+FLKARLICS P + F+ L+DVF++ K PV
Sbjct: 265 IGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVV 324
Query: 310 YALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGA 369
Y +FT N SAVC Y++S VF G Y + + +WV Y G VP PRPG
Sbjct: 325 YGVFTTSSNIFKGSAVCMYSMSDVRRVFL-GPYAHR---DGPNYQWVPYQGRVPYPRPGT 380
Query: 370 CIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDR 427
C + S+ +LPD + F + HP M + V P++NRP +IK DVNY TQIVVDR
Sbjct: 381 C--PSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDR 438
Query: 428 TQALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEETQLFQDFEPVQTLLLSSK 481
A DG YDVMF+ TD G + K +S+ ++EE +F++ + + LS+K
Sbjct: 439 VDAEDGQ-YDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTK 497
Query: 482 KGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAW 522
+ + +Y GS +GV Q PL C +G C +C LARDPYCAW
Sbjct: 498 Q--QQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAW 537
>gi|5454048 semaphorin 3C [Homo sapiens]
Length = 751
Score = 331 bits (848), Expect = 2e-90
Identities = 196/499 (39%), Positives = 285/499 (57%), Gaps = 32/499 (6%)
Query: 43 HEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGK 102
H P +Y LL+ ED+D +Y+G+++ + ++N NIS++ V+W S K +C GK
Sbjct: 49 HHP--LDYRILLMDEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGK 106
Query: 103 SKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNL------TSFKFLGKNEDGKGRC 156
C N++RV+Q + T LYVCG+ AF P C +LN F K E GKGRC
Sbjct: 107 DPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCESGKGRC 166
Query: 157 PFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFA 214
F+P + SVM++ EL+SG +F+G++ I R+ + + +RT ++ WL+EP FV A
Sbjct: 167 SFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDA 226
Query: 215 DVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSF 274
VI PD D D +VYFFF E + + + IAR+C D GGLR+L KWT+F
Sbjct: 227 HVI---PDGTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTF 283
Query: 275 LKARLICSRPDSG---LVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLS 331
LKARL+CS D F+ L DVF+L + + + Y +FT + SAVC Y+LS
Sbjct: 284 LKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLS 343
Query: 332 TAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTL 391
+ VF +G + E + + + Y G +P PRPG C A N ++ PD +
Sbjct: 344 DIQTVF-NGPFAHK---EGPNHQLISYQGRIPYPRPGTC-PGGAFTPNMRTTKEFPDDVV 398
Query: 392 QFVKDHPLMDDSVTPIDNRPRLIK--KDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALH 449
F+++HPLM +S+ PI RP +++ D YT+I VDR A DG Y V+F+ TDRG +
Sbjct: 399 TFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGR-YHVLFLGTDRGTVQ 457
Query: 450 KAISL--EHAVH---IIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCG 504
K + L ++V I+EE ++F++ P+ T+ +SSKK + +Y SN GV Q L C
Sbjct: 458 KVVVLPTNNSVSGELILEELEVFKNHAPITTMKISSKK--QQLYVSSNEGVSQVSLHRCH 515
Query: 505 KHGT-CEDCVLARDPYCAW 522
+GT C DC LARDPYCAW
Sbjct: 516 IYGTACADCCLARDPYCAW 534
>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
Length = 749
Score = 323 bits (827), Expect = 5e-88
Identities = 210/579 (36%), Positives = 309/579 (53%), Gaps = 40/579 (6%)
Query: 7 IRGLLMALAVMFGTAMAFAPIPRITWEHREVH--LVQFHEPDIYNYSALLLSEDKDTLYI 64
I GL + AV G+A P R++++ + L F Y ALL+ E++ L++
Sbjct: 10 IPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFV 69
Query: 65 GAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLY 124
GA V ++N NIS++ ++ W + + +C GK TEC+N++++L + T L
Sbjct: 70 GAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLL 129
Query: 125 VCGTNAFQPACDHLNL---TSFKFL----GKNEDGKGRCPFDPAHSYTSVMVDGELYSGT 177
CGT AF P C + + L G+ EDGKG+ P+DP H SV+V ELYSG
Sbjct: 130 ACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGV 189
Query: 178 SYNFLGSEPIISRNSSHSP-LRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFF 235
+ + +G + I R+ P LRTE + WLNEP FV I P+S + +DD++YFFF
Sbjct: 190 AADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWI---PESENPDDDKIYFFF 246
Query: 236 TEVSVE-YEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP--DSGLVFNV 292
E +VE + R+ + R+ ++C+ D GG R+L KWT+FLKARL+CS P + F+
Sbjct: 247 RETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQ 306
Query: 293 LRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSH 352
L+DVF+L S + P+ YA+F+ + SAVC Y+++ F G + E
Sbjct: 307 LQDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFL-GPFAHK---EGPM 362
Query: 353 TKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPR 412
+WV Y G VP PRPG C ++S+ + PD +QF ++HPLM +SV P RP
Sbjct: 363 HQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 420
Query: 413 LIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEET 464
++ NY TQI DR A DG YDV+F+ TD G + K IS+ ++EE
Sbjct: 421 FLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEEL 479
Query: 465 QLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAWS 523
+F+D V ++ +SSK+ +Y S S V Q L C HG C +C LARDPYCAW
Sbjct: 480 HVFEDSAAVTSMQISSKRHQ--LYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWD 537
Query: 524 PPTATCVALHQTESPSRGLIQEM-SGDAS-VCPASSPKP 560
T Q + R Q++ +GD S +C S +P
Sbjct: 538 GVACT---RFQPSAKRRFRRQDVRNGDPSTLCSGDSSRP 573
>gi|41406086 semaphorin 3D [Homo sapiens]
Length = 777
Score = 322 bits (826), Expect = 6e-88
Identities = 200/548 (36%), Positives = 300/548 (54%), Gaps = 47/548 (8%)
Query: 11 LMALAVMFGTAMAFAP--------IPRITWEHREVHLVQFHEPDI-----YNYSALLLSE 57
L +M M F P IPR+ ++++ L P + ++ LLL E
Sbjct: 18 LFPALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDE 77
Query: 58 DKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQP 117
++ L +GA++ +F ++ +++++ ++YW ++++ C GK TEC N+IRVLQP
Sbjct: 78 ERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQP 137
Query: 118 LSATSLYVCGTNAFQPACDHLNL------TSFKFLGKN-EDGKGRCPFDPAHSYTSVMVD 170
+ T +YVCGT AF P C +++L FK N E G+ +CPFDP + SVM D
Sbjct: 138 YNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTD 197
Query: 171 GELYSGTSYNFLGSEPIISRN----SSHSPLRTEYAIP-WLNEPSFVFADVIRKSPDSPD 225
LYSGT+ +FLG + +R+ H +RT+ + WLN F+ I PD+ +
Sbjct: 198 EYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFI---PDTYN 254
Query: 226 GEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPD 285
+DD++YFFF E S E + ++ R+ RVCK D GG R+L KWT+FLKARLICS P
Sbjct: 255 PDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPG 314
Query: 286 S---GLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKY 342
S F+ L+D+++L + + PV Y +FT + SAVC Y+++ VF +G Y
Sbjct: 315 SDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVF-NGPY 373
Query: 343 MQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDD 402
E + +WV+Y+G +P PRPG C S+ S+ + PD + F+K H +M
Sbjct: 374 AHK---ESADHRWVQYDGRIPYPRPGTC-PSKTYDPLIKSTRDFPDDVISFIKRHSVMYK 429
Query: 403 SVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH- 459
SV P+ P + +V+Y TQIVVD A DG YDVMF+ TD G + K +S+
Sbjct: 430 SVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQ-YDVMFLGTDIGTVLKVVSISKEKWN 488
Query: 460 ----IIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVL 514
++EE Q+F+ + + LS K+ + +Y GS G+VQ L C +G C DC L
Sbjct: 489 MEEVVLEELQIFKHSSIILNMELSLKQ--QQLYIGSRDGLVQLSLHRCDTYGKACADCCL 546
Query: 515 ARDPYCAW 522
ARDPYCAW
Sbjct: 547 ARDPYCAW 554
>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
Length = 748
Score = 321 bits (822), Expect = 2e-87
Identities = 211/579 (36%), Positives = 309/579 (53%), Gaps = 41/579 (7%)
Query: 7 IRGLLMALAVMFGTAMAFAPIPRITWEHREVH--LVQFHEPDIYNYSALLLSEDKDTLYI 64
I GL + AV G+A P R++++ + L F Y ALL+ E++ L++
Sbjct: 10 IPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFV 69
Query: 65 GAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLY 124
GA V ++N NIS++ ++ W + + +C GK TEC+N++++L + T L
Sbjct: 70 GAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLL 129
Query: 125 VCGTNAFQPACDHLNL---TSFKFL----GKNEDGKGRCPFDPAHSYTSVMVDGELYSGT 177
CGT AF P C + + L G+ EDGKG+ P+DP H SV+V ELYSG
Sbjct: 130 ACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGV 189
Query: 178 SYNFLGSEPIISRNSSHSP-LRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFF 235
+ + +G + I R+ P LRTE + WLNEP FV I P+S + +DD++YFFF
Sbjct: 190 AADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWI---PESENPDDDKIYFFF 246
Query: 236 TEVSVE-YEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP--DSGLVFNV 292
E +VE + R+ + R+ ++C+ D GG R+L KWT+FLKARL+CS P + F+
Sbjct: 247 RETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQ 306
Query: 293 LRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSH 352
L+DVF+L S + P+ YA+F+ G SAVC Y+++ F G + E
Sbjct: 307 LQDVFLLSSRDHRTPLLYAVFSTSSIFQG-SAVCVYSMNDVRRAFL-GPFAHK---EGPM 361
Query: 353 TKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPR 412
+WV Y G VP PRPG C ++S+ + PD +QF ++HPLM +SV P RP
Sbjct: 362 HQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 419
Query: 413 LIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEET 464
++ NY TQI DR A DG YDV+F+ TD G + K IS+ ++EE
Sbjct: 420 FLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEEL 478
Query: 465 QLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAWS 523
+F+D V ++ +SSK+ +Y S S V Q L C HG C +C LARDPYCAW
Sbjct: 479 HVFEDSAAVTSMQISSKRHQ--LYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWD 536
Query: 524 PPTATCVALHQTESPSRGLIQEM-SGDAS-VCPASSPKP 560
T Q + R Q++ +GD S +C S +P
Sbjct: 537 GVACT---RFQPSAKRRFRRQDVRNGDPSTLCSGDSSRP 572
>gi|6912650 semaphorin 3E [Homo sapiens]
Length = 775
Score = 309 bits (791), Expect = 7e-84
Identities = 191/521 (36%), Positives = 284/521 (54%), Gaps = 38/521 (7%)
Query: 28 PRITWEHREVHLVQ----FHEP-DIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQ 82
PR+ H+E+ + FH P + +LL E ++ L++G R+ V++++ IS+
Sbjct: 31 PRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY 90
Query: 83 HEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACD------ 136
E++W + K +C KGK EC NY+RVL + T L CGT AF P C
Sbjct: 91 KEIHWPSTALKMEECIMKGKDAG-ECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGY 149
Query: 137 HLNLTSFKFLG-KNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSH- 194
HL F ++E G+GRCPFDP+ S+ S ++ EL++G ++ + I R+
Sbjct: 150 HLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRL 209
Query: 195 SPLRTEYAIP-WLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRI 253
+ +RTE+ L EP FV + +I PD+ D +D++VYFFFTE ++E E + R+
Sbjct: 210 AHIRTEHDDERLLKEPKFVGSYMI---PDNEDRDDNKVYFFFTEKALEAENNAHAIYTRV 266
Query: 254 ARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVFY 310
R+C D GG R L KW++FLKARL+CS P + F+ L DVF+L + K PV +
Sbjct: 267 GRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIF 326
Query: 311 ALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGAC 370
LF N A+C Y++S+ F +G Y E W Y G VP PRPG+C
Sbjct: 327 GLFNTTSNIFRGHAICVYHMSSIRAAF-NGPYAHK---EGPEYHWSVYEGKVPYPRPGSC 382
Query: 371 IDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYT--QIVVDRT 428
S+ Y ++ + PD ++F + HPLM ++ P +P L+K D Y QI VDR
Sbjct: 383 A-SKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRV 441
Query: 429 QALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEETQLFQDFEPVQTLLLSSKK 482
+A DG YDV+F+ TD G + K I++ + I+EE Q+F+D P+ ++ +SSK+
Sbjct: 442 EAEDGQ-YDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKR 500
Query: 483 GNRFVYAGSNSGVVQAPLAFCGKHGT-CEDCVLARDPYCAW 522
+ +Y GS S V Q C +G+ C DC LARDPYCAW
Sbjct: 501 --QQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAW 539
>gi|188497703 semaphorin 3F [Homo sapiens]
Length = 785
Score = 299 bits (765), Expect = 7e-81
Identities = 181/525 (34%), Positives = 281/525 (53%), Gaps = 63/525 (12%)
Query: 49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTEC 108
+Y LL ED D +Y+G+++ V +++ +I+ + ++W S + +C GK EC
Sbjct: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGEC 115
Query: 109 LNYIRVLQPLSATSLYVCGTNAFQPACDHLN------------LTSFKFLGKN------- 149
N++R++QP + T LYVCGT A+ P C ++N + + G
Sbjct: 116 GNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALR 175
Query: 150 -------------------EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISR 190
E GKG+CP+DP S +++ ELY+G +F+G++ I R
Sbjct: 176 PMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFR 235
Query: 191 N-SSHSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRV 248
+ +RT+ Y WLN+PSF+ A++I PDS + DD++YFFF E S E
Sbjct: 236 TLGKQTAMRTDQYNSRWLNDPSFIHAELI---PDSAERNDDKLYFFFRERSAEAP-QSPA 291
Query: 249 LIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLK 305
+ RI R+C D GG L KW++FLKARL+CS P + F+ L+DVFV ++ ++
Sbjct: 292 VYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR 351
Query: 306 VPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKP 365
PV YA+FT + SAVC Y+++ VF +G + E + +W+ ++G +P P
Sbjct: 352 NPVIYAVFTSSGSVFRGSAVCVYSMADIRMVF-NGPFAHK---EGPNYQWMPFSGKMPYP 407
Query: 366 RPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQI 423
RPG C + S+ + PD+ + F++ HPLM +V P+ RP +++ Y T I
Sbjct: 408 RPGTC-PGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTI 466
Query: 424 VVDRTQALDGTVYDVMFVSTDRGALHKAISL-----EHAVHIIEETQLFQDFEPVQTLLL 478
VD+ A DG Y+V+F+ TDRG + K I L E ++EE ++F+D PV+T+ +
Sbjct: 467 AVDQVDAADGR-YEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTI 525
Query: 479 SSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAW 522
SSK+ + +Y S GV L C +G C DC LARDPYCAW
Sbjct: 526 SSKR--QQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAW 568
>gi|9910362 semaphorin sem2 [Homo sapiens]
Length = 782
Score = 297 bits (761), Expect = 2e-80
Identities = 189/502 (37%), Positives = 269/502 (53%), Gaps = 32/502 (6%)
Query: 49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTEC 108
N A+ L E +D L++G +A++++ EV W ++ +C KG+ TEC
Sbjct: 57 NLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTEC 116
Query: 109 LNYIRVLQPLSATSLYVCGTNAFQPACDHLNL------TSFKFLGKNEDGKGRCPFDPAH 162
N++RVLQP + T L CGT AFQP C + + G E G+GRCP +P+
Sbjct: 117 ANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSR 176
Query: 163 SYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-LRTEYAIPWLNEPSFVFADVIRKSP 221
+ S +DGELY+G + +FLG E +I R+ P LR++ L++P FV A + P
Sbjct: 177 PFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMA---ARIP 233
Query: 222 DSPDGEDDRVYFFFTE-VSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLI 280
++ D ++D+VYFFF+E V V + R+ RVC D GG R L KW++FLKARL+
Sbjct: 234 ENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLV 293
Query: 281 CSRPDSG---LVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVF 337
CS P G F+ L DVF+L K YALF+ AVC Y+++ EVF
Sbjct: 294 CSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVF 353
Query: 338 SHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAAN--YTSSLNLPDKTLQFVK 395
+G + + +W Y G VP PRPG C + S+ + PD+ LQF +
Sbjct: 354 -NGPFAHR---DGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFAR 409
Query: 396 DHPLMDDSVTPIDNRPRLIKKDV--NYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAIS 453
HPLM V P RP L+K + QIVVDR +A DGT YDV+F+ TD G++ K I+
Sbjct: 410 AHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGT-YDVIFLGTDSGSVLKVIA 468
Query: 454 L------EHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG 507
L E ++EE Q+F+ P+ + +S K+ + +Y GS GV Q L C +G
Sbjct: 469 LQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKR--QMLYVGSRLGVAQLRLHQCETYG 526
Query: 508 T-CEDCVLARDPYCAWSPPTAT 528
T C +C LARDPYCAW + T
Sbjct: 527 TACAECCLARDPYCAWDGASCT 548
>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
Length = 1011
Score = 281 bits (718), Expect = 2e-75
Identities = 177/494 (35%), Positives = 275/494 (55%), Gaps = 44/494 (8%)
Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109
L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC
Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119
Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169
N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++
Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179
Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227
DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A
Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229
Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285
+ VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344
S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ +
Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346
Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404
T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V
Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403
Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAI------SLEH 456
PI + P K V Y T I VD + A Y V+FV ++ G + K + SL
Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLND 462
Query: 457 AVHIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC 509
+V ++EE + + ++ E + + L K + +Y +S +++ PL+ C ++G+C
Sbjct: 463 SV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSC 521
Query: 510 -EDCVLARDPYCAW 522
+ C+ +RDPYC W
Sbjct: 522 KKSCIASRDPYCGW 535
>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
Length = 597
Score = 281 bits (718), Expect = 2e-75
Identities = 177/494 (35%), Positives = 275/494 (55%), Gaps = 44/494 (8%)
Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109
L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC
Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119
Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169
N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++
Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179
Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227
DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A
Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229
Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285
+ VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344
S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ +
Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346
Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404
T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V
Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403
Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAI------SLEH 456
PI + P K V Y T I VD + A Y V+FV ++ G + K + SL
Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLND 462
Query: 457 AVHIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC 509
+V ++EE + + ++ E + + L K + +Y +S +++ PL+ C ++G+C
Sbjct: 463 SV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSC 521
Query: 510 -EDCVLARDPYCAW 522
+ C+ +RDPYC W
Sbjct: 522 KKSCIASRDPYCGW 535
>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
Length = 1073
Score = 281 bits (718), Expect = 2e-75
Identities = 177/494 (35%), Positives = 275/494 (55%), Gaps = 44/494 (8%)
Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109
L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC
Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119
Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169
N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++
Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179
Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227
DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A
Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229
Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285
+ VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344
S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ +
Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346
Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404
T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V
Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403
Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAI------SLEH 456
PI + P K V Y T I VD + A Y V+FV ++ G + K + SL
Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLND 462
Query: 457 AVHIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC 509
+V ++EE + + ++ E + + L K + +Y +S +++ PL+ C ++G+C
Sbjct: 463 SV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSC 521
Query: 510 -EDCVLARDPYCAW 522
+ C+ +RDPYC W
Sbjct: 522 KKSCIASRDPYCGW 535
>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
Length = 1017
Score = 281 bits (718), Expect = 2e-75
Identities = 177/494 (35%), Positives = 275/494 (55%), Gaps = 44/494 (8%)
Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109
L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC
Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119
Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169
N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++
Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179
Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227
DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A
Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229
Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285
+ VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344
S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ +
Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346
Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404
T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V
Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403
Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAI------SLEH 456
PI + P K V Y T I VD + A Y V+FV ++ G + K + SL
Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLND 462
Query: 457 AVHIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC 509
+V ++EE + + ++ E + + L K + +Y +S +++ PL+ C ++G+C
Sbjct: 463 SV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSC 521
Query: 510 -EDCVLARDPYCAW 522
+ C+ +RDPYC W
Sbjct: 522 KKSCIASRDPYCGW 535
>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
Length = 998
Score = 281 bits (718), Expect = 2e-75
Identities = 177/494 (35%), Positives = 275/494 (55%), Gaps = 44/494 (8%)
Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109
L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC
Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119
Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169
N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++
Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179
Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227
DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A
Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229
Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285
+ VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344
S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ +
Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346
Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404
T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V
Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403
Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAI------SLEH 456
PI + P K V Y T I VD + A Y V+FV ++ G + K + SL
Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLND 462
Query: 457 AVHIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC 509
+V ++EE + + ++ E + + L K + +Y +S +++ PL+ C ++G+C
Sbjct: 463 SV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSC 521
Query: 510 -EDCVLARDPYCAW 522
+ C+ +RDPYC W
Sbjct: 522 KKSCIASRDPYCGW 535
>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
domain, (semaphorin) 6A [Homo sapiens]
Length = 1030
Score = 268 bits (684), Expect = 2e-71
Identities = 178/496 (35%), Positives = 267/496 (53%), Gaps = 47/496 (9%)
Query: 61 TLYIGAREAVFAVNALNISEKQHEVY------WKVSEDKKAKCAEKGKSKQTECLNYIRV 114
TLYI AR+ ++ V+ ++ S + E+Y WK + C KGK K EC N+I+V
Sbjct: 67 TLYIAARDHIYTVD-IDTSHTE-EIYCSKKLTWKSRQADVDTCRMKGKHKD-ECHNFIKV 123
Query: 115 LQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELY 174
L + +L+VCGTNAF P+C + + + + G G RCP+D H+ ++ DG+LY
Sbjct: 124 LLKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFADGKLY 183
Query: 175 SGTSYNFLGSEPIISRNSSHSP-LRT-EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVY 232
S T +FL + +I R+ SP LRT ++ WL EP FV A D +Y
Sbjct: 184 SATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQA----------VDYGDYIY 233
Query: 233 FFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-DSGLVF 290
FFF E++VEY + +V+ PR+A+VCK D GG R L+K+WTSFLKARL CS P DS F
Sbjct: 234 FFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYF 293
Query: 291 NVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349
N+L+ V V+R G V + A F+ N++ SAVCAY++ VF+ G++ + + +
Sbjct: 294 NILQAVTDVIRINGRDVVL--ATFSTPYNSIPGSAVCAYDMLDIASVFT-GRFKEQKSPD 350
Query: 350 QSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409
+ T + VPKPRPG C S + Y +S PD TL F+K HPLMD++V I N
Sbjct: 351 STWTPVP--DERVPKPRPGCCAGSSS-LERYATSNEFPDDTLNFIKTHPLMDEAVPSIFN 407
Query: 410 RPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGA-------------LHKAISL 454
RP ++ V Y T+I VD T A + V+F+ +++G L+ ++ L
Sbjct: 408 RPWFLRTMVRYRLTKIAVD-TAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFL 466
Query: 455 EHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC-EDCV 513
E E + E + + + + + +Y ++ V++ PL C +HG C + C+
Sbjct: 467 EEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCI 526
Query: 514 LARDPYCAWSPPTATC 529
+RDPYC W C
Sbjct: 527 ASRDPYCGWIKEGGAC 542
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 261 bits (668), Expect = 1e-69
Identities = 192/605 (31%), Positives = 294/605 (48%), Gaps = 73/605 (12%)
Query: 23 AFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQ 82
A + P + +E + + F P ++S L L + L +GAR +F ++ N+S Q
Sbjct: 99 ALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQ 158
Query: 83 HEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTS 142
W SED + C KGK+++ EC NY+RVL ++ +++CGTNAF P C + +
Sbjct: 159 -ATEWASSEDTRRSCQSKGKTEE-ECQNYVRVLI-VAGRKVFMCGTNAFSPMCTSRQVGN 215
Query: 143 FKFLGKNEDGKGRCPFDPAHSYTSVMVD-GELYSGTSYNFLGSEPIISRN-SSHSPLRT- 199
+ +G RCP+DP H+ T+V+ GELY+ T +F G +P I R+ S PLRT
Sbjct: 216 LSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTA 275
Query: 200 EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKG 259
+Y WLNEP+FV A I YFF E +VE++ R + R+ARVCK
Sbjct: 276 QYNSKWLNEPNFVAAYDIGLF----------AYFFLRENAVEHD-CGRTVYSRVARVCKN 324
Query: 260 DQGGLRTLQKKWTSFLKARLICSRP-DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLN 318
D GG L+ WT+F+KARL CSRP + +N L+ F L L Y +FT +N
Sbjct: 325 DVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDL----IYGVFTTNVN 380
Query: 319 NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAA 378
++ SAVCA+NLS + F+ Q E W+ P+P + G ++
Sbjct: 381 SIAASAVCAFNLSAISQAFNGPFRYQ----ENPRAAWLPIANPIPNFQCGTLPETGPNE- 435
Query: 379 NYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDV 438
NL +++LQ + LM ++V P+ P + + V ++ +VVD QA D T+Y V
Sbjct: 436 ------NLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKD-TLYHV 488
Query: 439 MFVSTDRGALHKAIS-LEHAVH--IIEETQLFQD--FEPVQTLLLSSKKGNRFVYAGSNS 493
+++ T+ G + KA+S ++H +EE + EP+++L + R ++ G
Sbjct: 489 LYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSA--RALFVGLRD 546
Query: 494 GVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQ-----------TESPSRGL 542
GV++ PL C + + C+ ARDPYC W C L T P R +
Sbjct: 547 GVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNV 606
Query: 543 IQE--------------MSGDAS---VCPASSPKPLPPPGSSSLSCLG---HVGDRRLSS 582
++ + GD S +C A S P P L CLG H+ + +
Sbjct: 607 TRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDS-PRPRCGGLDCLGPAIHIANCSRNG 665
Query: 583 PWTPW 587
WTPW
Sbjct: 666 AWTPW 670
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 249 bits (635), Expect = 8e-66
Identities = 180/569 (31%), Positives = 285/569 (50%), Gaps = 63/569 (11%)
Query: 28 PRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYW 87
P I+++ L +F + ++S L + L +GAR +F + ++S Q V W
Sbjct: 36 PVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQ-AVEW 94
Query: 88 KVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLG 147
+ E K C KGKSK+ EC NYIRVL + L+ CGTNAF P C + +L++ +
Sbjct: 95 ECDEATKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTEIH 152
Query: 148 KNEDGKGRCPFDPAHSYTSVMV-DGELYSGTSYNFLGSEPIISRNSSH-SPLRT-EYAIP 204
G RCP+ P H+ T+++ GELY+ T+ +F G +P I R+ PLRT +Y
Sbjct: 153 DQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSK 212
Query: 205 WLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGL 264
WLNEP+FV + I + YFFF E +VE++ + + R ARVCK D GG
Sbjct: 213 WLNEPNFVSSYDI----------GNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGR 261
Query: 265 RTLQKKWTSFLKARLICSRP-DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLS 323
L+ WT+F+KARL CSRP + +N L+ F L ++ + Y +FT +N++ S
Sbjct: 262 FLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLP----ELDLIYGIFTTNVNSIAAS 317
Query: 324 AVCAYNLSTAEEVFSHG-KYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTS 382
AVC +NLS + FS KY E S + W+ P P P P + +
Sbjct: 318 AVCVFNLSAIAQAFSGPFKYQ-----ENSRSAWL----PYPNPNP----HFQCGTVDQGL 364
Query: 383 SLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVS 442
+NL ++ LQ + LM + V P+ P ++ + ++ + VD Q + V+ +++++
Sbjct: 365 YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVH-IIYLA 423
Query: 443 TDRGALHKA---ISLEHAVHIIEETQLFQD--FEPVQTLLLSSKKGNRFVYAGSNSGVVQ 497
TD G + K ++ + ++EE +LF + EP+++L + + FV G VV+
Sbjct: 424 TDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFV--GLREHVVK 481
Query: 498 APLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPASS 557
PL C + T C+ A+DPYC W C +L ++ S + + S CP
Sbjct: 482 IPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLS-----MTQWEQSISACP--- 533
Query: 558 PKPLPPPGSSSLSCLGHVGDRRLSSPWTP 586
+ +L+ GH G + SPWTP
Sbjct: 534 --------TRNLTVDGHFG---VWSPWTP 551
>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
Length = 476
Score = 248 bits (634), Expect = 1e-65
Identities = 155/411 (37%), Positives = 232/411 (56%), Gaps = 29/411 (7%)
Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109
L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC
Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119
Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169
N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++
Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179
Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227
DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A
Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229
Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285
+ VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289
Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344
S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ +
Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346
Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404
T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V
Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403
Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAIS 453
PI + P K V Y T I VD + A Y V+FV ++ G + K ++
Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLA 453
>gi|19718780 semaphorin 6B precursor [Homo sapiens]
Length = 888
Score = 234 bits (598), Expect = 2e-61
Identities = 166/500 (33%), Positives = 266/500 (53%), Gaps = 48/500 (9%)
Query: 61 TLYIGAREAVFAVNALNISEK----QHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQ 116
TL+IG R+ ++ V + Q ++ W+ + C KGK ++ EC N+++VL
Sbjct: 76 TLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGK-QEGECRNFVKVLL 134
Query: 117 PLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSG 176
++L+VCG+NAF P C + ++ + + +G N G RCP+DP H+ ++ DG L++
Sbjct: 135 LRDESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTA 194
Query: 177 TSYNFLGSEPIISRNSSHSP-LRT-EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFF 234
T +FL + +I R+ P LRT ++ W EP FV A VYFF
Sbjct: 195 TVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHA----------VEWGSHVYFF 244
Query: 235 FTEVSVEYEFVFRVLIPRIARVCKGDQGGL-RTLQKKWTSFLKARLICSRP-DSGLVFNV 292
F E+++E+ ++ +V++ R+ARVCK D GG R L+K+WTSFLKARL CS P DS FNV
Sbjct: 245 FREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNV 304
Query: 293 LRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSH 352
L+ V + S G + PV A+F+ N++ SAVCA++L+ VF G++ + + E
Sbjct: 305 LQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVF-EGRFREQKSPESIW 362
Query: 353 TKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPR 412
T VP+PRPG C A Y +S LPD L FVK HPLMD++V + + P
Sbjct: 363 TPVP--EDQVPRPRPGCC---AAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPW 417
Query: 413 LIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH--------IIE 462
+++ + + T++ VD G V+F+ ++ G + K + +A +E
Sbjct: 418 ILRTLMRHQLTRVAVDVGAGPWGN-QTVVFLGSEAGTVLKFLVRPNASTSGTSGLSVFLE 476
Query: 463 ETQLFQ--------DFEPVQTLL-LSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC-EDC 512
E + ++ E Q LL L + + A VV+ P+A C ++ C ++C
Sbjct: 477 EFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNC 536
Query: 513 VLARDPYCAWSPPTATCVAL 532
+ ++DPYC W+ P +C+ L
Sbjct: 537 IGSQDPYCGWA-PDGSCIFL 555
>gi|16306552 semaphorin Y [Homo sapiens]
Length = 930
Score = 234 bits (597), Expect = 2e-61
Identities = 174/496 (35%), Positives = 248/496 (50%), Gaps = 62/496 (12%)
Query: 61 TLYIGAREAVFAVNALNISEKQHEV-----YWKVSEDKKAKCAEKGKSKQTECLNYIRVL 115
TL + AR+ VF+ + E + V W+ S+D + CA +GK EC NYIRVL
Sbjct: 72 TLLVAARDHVFSFDLQAEEEGEGLVPNKYLTWR-SQDVE-NCAVRGKLTD-ECYNYIRVL 128
Query: 116 QPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYS 175
P + +L CGTN+F P C +TS + G+ G+ RCPFD S ++ +G LYS
Sbjct: 129 VPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYS 188
Query: 176 GTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYF 233
T+ +F S+ ++ R+ PLR+ +Y WL EP FV A D VYF
Sbjct: 189 ATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQALE----------HGDHVYF 238
Query: 234 FFTEVSVEYEFVFRVLIPRIARVCKGDQGGL-RTLQKKWTSFLKARLICSRP-DSGLVFN 291
FF EVSVE + RV R+ARVCK D GG R L + WTSFLK RL CS P DS F+
Sbjct: 239 FFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFD 298
Query: 292 VLRDVFVLRSPGLKVPV-------FYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344
VL+ L PV + +FT Q N++ SAVCA+ L E F GK+ +
Sbjct: 299 VLQ--------ALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFE-GKFKE 349
Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404
+++ + T VP PRPG+C AA ++SS +LPD L F+K HPL+D +V
Sbjct: 350 QRSLDGAWTPVSEDR--VPSPRPGSCA-GVGGAALFSSSRDLPDDVLTFIKAHPLLDPAV 406
Query: 405 TPIDNRPRL-IKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEE 463
P+ ++P L + TQ+ VD + VMF+ ++ G + K ++ E
Sbjct: 407 PPVTHQPLLTLTSRALLTQVAVDGMAGPHSNI-TVMFLGSNDGTVLKVLT-PGGRSGGPE 464
Query: 464 TQLFQDFEPVQTLLLSSKK----------------GNRFVYAGSNSGVVQAPLAFCGKHG 507
L ++ + S K+ G+R A S +V PL+ C +HG
Sbjct: 465 PILLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGC-IVYLPLSRCARHG 523
Query: 508 TCE-DCVLARDPYCAW 522
C+ C+ ++DPYC W
Sbjct: 524 ACQRSCLASQDPYCGW 539
>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
Length = 666
Score = 190 bits (482), Expect = 5e-48
Identities = 155/546 (28%), Positives = 243/546 (44%), Gaps = 77/546 (14%)
Query: 29 RITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWK 88
R+ + E H V FHEP ++++G R V+ + K V
Sbjct: 66 RVDFGQTEPHTVLFHEPG------------SSSVWVGGRGKVYLFDFPE--GKNASVRTV 111
Query: 89 VSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGK 148
K C +K +C NYI +L+ S L CGTNA P+C +L + LG+
Sbjct: 112 NIGSTKGSCLDK-----RDCENYITLLERRSE-GLLACGTNARHPSCWNLVNGTVVPLGE 165
Query: 149 NEDGKGRCPFDPAHSYTSVMVDGELYSGT-SYNFLGSEPIISRNSSHSPLRTEYAIPWLN 207
+G PF P + + E+YS + G P R S L T + +
Sbjct: 166 M---RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQ 220
Query: 208 EPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTL 267
P F+ A ++ + DD++Y+FF E + + + + R+A++C+GDQGG +L
Sbjct: 221 NPQFIKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSL 276
Query: 268 Q-KKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPG--LKVPVFYALFTPQLNNVGLSA 324
KW +FLKA L+CS + FN L+DVF+L P + Y +F+ N SA
Sbjct: 277 SVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFS---NPWNYSA 333
Query: 325 VCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSL 384
VC Y+L ++VF Y+ +P PRPG C+ +
Sbjct: 334 VCVYSLGDIDKVFRTSSLK-------------GYHSSLPNPRPGKCLPDQQ--------- 371
Query: 385 NLPDKTLQFVKDHPLMDDSVTPIDN-RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVST 443
+P +T Q HP + V P+ + L +Y ++ V R QA G + V++++T
Sbjct: 372 PIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTT 431
Query: 444 DRGALHKAISLEHAVHI----IEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAP 499
DRG +HK + H I E Q F+ +QT+ L +++ R +Y S V Q P
Sbjct: 432 DRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAER--RKLYVSSQWEVSQVP 489
Query: 500 LAFCGKH-GTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPASSP 558
L C + G C C+++RDPYC W C++++ +E R ++Q S+ PA
Sbjct: 490 LDLCEVYGGGCHGCLMSRDPYCGWD--QGRCISIYSSE---RSVLQ------SINPAEPH 538
Query: 559 KPLPPP 564
K P P
Sbjct: 539 KECPNP 544
>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
Length = 652
Score = 190 bits (482), Expect = 5e-48
Identities = 155/546 (28%), Positives = 243/546 (44%), Gaps = 91/546 (16%)
Query: 29 RITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWK 88
R+ + E H V FHEP ++++G R V+ +
Sbjct: 66 RVDFGQTEPHTVLFHEP------------GSSSVWVGGRGKVY--------------LFD 99
Query: 89 VSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGK 148
E K A S +T+C NYI +L+ S L CGTNA P+C +L + LG
Sbjct: 100 FPEGKNA-------SVRTDCENYITLLERRS-EGLLACGTNARHPSCWNLVNGTVVPLG- 150
Query: 149 NEDGKGRCPFDPAHSYTSVMVDGELYSG-TSYNFLGSEPIISRNSSHSPLRTEYAIPWLN 207
+ +G PF P + + E+YS + G P R S L T + +
Sbjct: 151 --EMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQ 206
Query: 208 EPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTL 267
P F+ A ++ + DD++Y+FF E + + + + R+A++C+GDQGG +L
Sbjct: 207 NPQFIKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSL 262
Query: 268 Q-KKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPG--LKVPVFYALFTPQLNNVGLSA 324
KW +FLKA L+CS + FN L+DVF+L P + Y +F+ N SA
Sbjct: 263 SVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFS---NPWNYSA 319
Query: 325 VCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSL 384
VC Y+L ++VF Y+ +P PRPG C+ +
Sbjct: 320 VCVYSLGDIDKVFRTSSLK-------------GYHSSLPNPRPGKCLPDQQ--------- 357
Query: 385 NLPDKTLQFVKDHPLMDDSVTPIDN-RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVST 443
+P +T Q HP + V P+ + L +Y ++ V R QA G + V++++T
Sbjct: 358 PIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTT 417
Query: 444 DRGALHKAISLEHAVHI----IEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAP 499
DRG +HK + H I E Q F+ +QT+ L +++ R +Y S V Q P
Sbjct: 418 DRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAER--RKLYVSSQWEVSQVP 475
Query: 500 LAFCGKH-GTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPASSP 558
L C + G C C+++RDPYC W C++++ +E R ++Q S+ PA
Sbjct: 476 LDLCEVYGGGCHGCLMSRDPYCGWD--QGRCISIYSSE---RSVLQ------SINPAEPH 524
Query: 559 KPLPPP 564
K P P
Sbjct: 525 KECPNP 530
>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
Length = 501
Score = 166 bits (419), Expect = 9e-41
Identities = 122/422 (28%), Positives = 194/422 (45%), Gaps = 54/422 (12%)
Query: 153 KGRCPFDPAHSYTSVMVDGELYSGT-SYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSF 211
+G PF P + + E+YS + G P R S L T + + P F
Sbjct: 2 RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQNPQF 59
Query: 212 VFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQ-KK 270
+ A ++ + DD++Y+FF E + + + + R+A++C+GDQGG +L K
Sbjct: 60 IKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSK 115
Query: 271 WTSFLKARLICSRPDSGLVFNVLRDVFVLRSPG--LKVPVFYALFTPQLNNVGLSAVCAY 328
W +FLKA L+CS + FN L+DVF+L P + Y +F+ N SAVC Y
Sbjct: 116 WNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFS---NPWNYSAVCVY 172
Query: 329 NLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPD 388
+L ++VF Y+ +P PRPG C+ + +P
Sbjct: 173 SLGDIDKVFRTSSLK-------------GYHSSLPNPRPGKCLPDQQ---------PIPT 210
Query: 389 KTLQFVKDHPLMDDSVTPIDN-RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGA 447
+T Q HP + V P+ + L +Y ++ V R QA G + V++++TDRG
Sbjct: 211 ETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGT 270
Query: 448 LHKAISLEHAVHI----IEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFC 503
+HK + H I E Q F+ +QT+ L +++ R +Y S V Q PL C
Sbjct: 271 IHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAER--RKLYVSSQWEVSQVPLDLC 328
Query: 504 GKH-GTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPASSPKPLP 562
+ G C C+++RDPYC W C++++ +E R ++Q S+ PA K P
Sbjct: 329 EVYGGGCHGCLMSRDPYCGWD--QGRCISIYSSE---RSVLQ------SINPAEPHKECP 377
Query: 563 PP 564
P
Sbjct: 378 NP 379
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,165,668
Number of Sequences: 37866
Number of extensions: 1532962
Number of successful extensions: 5822
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 5335
Number of HSP's gapped (non-prelim): 352
length of query: 738
length of database: 18,247,518
effective HSP length: 110
effective length of query: 628
effective length of database: 14,082,258
effective search space: 8843658024
effective search space used: 8843658024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.