BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] (738 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] 1517 0.0 gi|214010218 semaphorin 4D isoform 1 [Homo sapiens] 1134 0.0 gi|157388902 semaphorin 4C [Homo sapiens] 469 e-132 gi|39777610 semaphorin 4B precursor [Homo sapiens] 456 e-128 gi|39777608 semaphorin 4B precursor [Homo sapiens] 456 e-128 gi|28872814 semaphorin 4G [Homo sapiens] 411 e-114 gi|19923279 semaphorin W [Homo sapiens] 379 e-105 gi|21361914 semaphorin B [Homo sapiens] 376 e-104 gi|5174673 semaphorin 3A precursor [Homo sapiens] 342 7e-94 gi|5454048 semaphorin 3C [Homo sapiens] 331 2e-90 gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens] 323 5e-88 gi|41406086 semaphorin 3D [Homo sapiens] 322 6e-88 gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens] 321 2e-87 gi|6912650 semaphorin 3E [Homo sapiens] 309 7e-84 gi|188497703 semaphorin 3F [Homo sapiens] 299 7e-81 gi|9910362 semaphorin sem2 [Homo sapiens] 297 2e-80 gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens] 281 2e-75 gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens] 281 2e-75 gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens] 281 2e-75 gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens] 281 2e-75 gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens] 281 2e-75 gi|11991660 sema domain, transmembrane domain (TM), and cytoplas... 268 2e-71 gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 261 1e-69 gi|147904700 semaphorin 5A [Homo sapiens] 249 8e-66 gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens] 248 1e-65 gi|19718780 semaphorin 6B precursor [Homo sapiens] 234 2e-61 gi|16306552 semaphorin Y [Homo sapiens] 234 2e-61 gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens] 190 5e-48 gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens] 190 5e-48 gi|225637524 semaphorin 7A isoform 3 [Homo sapiens] 166 9e-41 >gi|214010220 semaphorin 4D isoform 2 [Homo sapiens] Length = 738 Score = 1517 bits (3928), Expect = 0.0 Identities = 738/738 (100%), Positives = 738/738 (100%) Query: 1 MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD 60 MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD Sbjct: 1 MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD 60 Query: 61 TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA 120 TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA Sbjct: 61 TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA 120 Query: 121 TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN 180 TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN Sbjct: 121 TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN 180 Query: 181 FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV 240 FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV Sbjct: 181 FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV 240 Query: 241 EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR 300 EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR Sbjct: 241 EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR 300 Query: 301 SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG 360 SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG Sbjct: 301 SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG 360 Query: 361 PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY 420 PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY Sbjct: 361 PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY 420 Query: 421 TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS 480 TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS Sbjct: 421 TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS 480 Query: 481 KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR 540 KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR Sbjct: 481 KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR 540 Query: 541 GLIQEMSGDASVCPASSPKPLPPPGSSSLSCLGHVGDRRLSSPWTPWPASGAGPDSSSRV 600 GLIQEMSGDASVCPASSPKPLPPPGSSSLSCLGHVGDRRLSSPWTPWPASGAGPDSSSRV Sbjct: 541 GLIQEMSGDASVCPASSPKPLPPPGSSSLSCLGHVGDRRLSSPWTPWPASGAGPDSSSRV 600 Query: 601 SLLPPFLSDQAQHVHALGNFYLFCQATGPADIRFVWEKNGRALETCVPVQTHALPDGRAH 660 SLLPPFLSDQAQHVHALGNFYLFCQATGPADIRFVWEKNGRALETCVPVQTHALPDGRAH Sbjct: 601 SLLPPFLSDQAQHVHALGNFYLFCQATGPADIRFVWEKNGRALETCVPVQTHALPDGRAH 660 Query: 661 ALSWLQDAIRESAEYRCSVLSSAGNKTSKVQVAVMRPEVTHQERWTRELSAWRAVAGEHD 720 ALSWLQDAIRESAEYRCSVLSSAGNKTSKVQVAVMRPEVTHQERWTRELSAWRAVAGEHD Sbjct: 661 ALSWLQDAIRESAEYRCSVLSSAGNKTSKVQVAVMRPEVTHQERWTRELSAWRAVAGEHD 720 Query: 721 RMMQSWRKAWESCSKDTL 738 RMMQSWRKAWESCSKDTL Sbjct: 721 RMMQSWRKAWESCSKDTL 738 >gi|214010218 semaphorin 4D isoform 1 [Homo sapiens] Length = 862 Score = 1134 bits (2934), Expect = 0.0 Identities = 555/557 (99%), Positives = 555/557 (99%) Query: 1 MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD 60 MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD Sbjct: 1 MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD 60 Query: 61 TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA 120 TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA Sbjct: 61 TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA 120 Query: 121 TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN 180 TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN Sbjct: 121 TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN 180 Query: 181 FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV 240 FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV Sbjct: 181 FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV 240 Query: 241 EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR 300 EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR Sbjct: 241 EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR 300 Query: 301 SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG 360 SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG Sbjct: 301 SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG 360 Query: 361 PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY 420 PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY Sbjct: 361 PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY 420 Query: 421 TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS 480 TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS Sbjct: 421 TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS 480 Query: 481 KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR 540 KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR Sbjct: 481 KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR 540 Query: 541 GLIQEMSGDASVCPASS 557 GLIQEMSGDASVCP S Sbjct: 541 GLIQEMSGDASVCPDKS 557 >gi|157388902 semaphorin 4C [Homo sapiens] Length = 833 Score = 469 bits (1208), Expect = e-132 Identities = 260/573 (45%), Positives = 350/573 (61%), Gaps = 25/573 (4%) Query: 27 IPRITWEHREVHLV--QFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHE 84 +PR T E+ V +F + I ++ L L+E LY+GAREA+FA + + E Q Sbjct: 28 VPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFS-MEALELQGA 86 Query: 85 VYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFK 144 + W+ +KK +C +KGK+ QTEC N+IR LQP +A+ LYVCGT AFQP C ++N+ +F Sbjct: 87 ISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNMLTFT 146 Query: 145 FL-GKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSS-HSPLRTEYA 202 G+ EDGKG+CP+DPA + ++VDGELYS T NFLG+EPII RN H ++TEY Sbjct: 147 LEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSMKTEYL 206 Query: 203 IPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQG 262 WLNEP FV + + +S S G+DD+VYFFF E +VE + ++ R+ARVCKGD G Sbjct: 207 AFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVCKGDMG 266 Query: 263 GLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGL 322 G RTLQ+KWT+FLKARL CS P+ L FN L+ + L+ F+ +F Q ++ L Sbjct: 267 GARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQWGDMYL 326 Query: 323 SAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTS 382 SA+C Y L + VF G Y + + KW RY PVP PRPG+CI++ R YTS Sbjct: 327 SAICEYQLEEIQRVF-EGPYKE---YHEEAQKWDRYTDPVPSPRPGSCINNWHRRHGYTS 382 Query: 383 SLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVS 442 SL LPD L FVK HPLM++ V P +RP L+KK N+T +V DR LDG Y V+F+ Sbjct: 383 SLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTVLFIG 442 Query: 443 TDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAF 502 T G L KA+SL VH+IEE QLF D EP+++L+LS K + ++AGS S +VQ P+A Sbjct: 443 TGDGWLLKAVSLGPWVHLIEELQLF-DQEPMRSLVLSQSK--KLLFAGSRSQLVQLPVAD 499 Query: 503 CGKHGTCEDCVLARDPYCAWSPPTATCVAL----------HQTESPSRGLIQEMSGDASV 552 C K+ +C DCVLARDPYCAWS T+ CVA+ H S + G I + G V Sbjct: 500 CMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSG-ICNLRGSKKV 558 Query: 553 CPASSPKPLPPPGSSSLSCLGHVGDRRLSSPWT 585 P +PK + + L H+ + WT Sbjct: 559 RP--TPKNITVVAGTDLVLPCHLSSNLAHARWT 589 >gi|39777610 semaphorin 4B precursor [Homo sapiens] Length = 837 Score = 456 bits (1173), Expect = e-128 Identities = 255/570 (44%), Positives = 355/570 (62%), Gaps = 29/570 (5%) Query: 6 PIRGLLMALAVMFGTAMAFAPIPRITWE--HREVHLVQFHEPDIYNYSALLLSEDKDTLY 63 P+ LL+ L ++ +A PRI+ E ++F I NY+ALLLS D TLY Sbjct: 24 PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLY 83 Query: 64 IGAREAVFAVNALNIS----EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS 119 +GAREA+FA+++ N+S + E+ W +KK +C+ KGK Q +C NYI++L PLS Sbjct: 84 VGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLS 142 Query: 120 ATSLYVCGTNAFQPACDHLNLTSFKFLGKN------EDGKGRCPFDPAHSYTSVMVDGEL 173 + L+ CGT AF P C ++N+ +F EDGKGRCPFDP T+++VDGEL Sbjct: 143 GSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGEL 202 Query: 174 YSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYF 233 Y+GT +F G++P ISR+ S P +TE ++ WL +P+FV + I +S S G+DD++YF Sbjct: 203 YTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYF 262 Query: 234 FFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVL 293 FF+E E+EF ++ RIAR+CKGD+GG R LQ++WTSFLKA+L+CSRPD G FNVL Sbjct: 263 FFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVL 322 Query: 294 RDVFVLR-SP-GLKVPVFYALFTPQLN--NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349 +DVF L SP + +FY +FT Q + SAVC + + + VFS G Y + V Sbjct: 323 QDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS-GLYKE---VN 378 Query: 350 QSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409 + +W PVP PRPGACI + AR SSL LPD+ L F+KDH LMD V + Sbjct: 379 RETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---S 435 Query: 410 RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQD 469 R L++ Y ++ V R L T YDV+F+ T G LHKA+S+ VHIIEE Q+F Sbjct: 436 RMLLLQPQARYQRVAVHRVPGLHHT-YDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSS 494 Query: 470 FEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATC 529 +PVQ LLL + +G +YA S+SGVVQ P+A C + +C DC+LARDPYCAWS + Sbjct: 495 GQPVQNLLLDTHRG--LLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWSGSSCKH 552 Query: 530 VALHQTESPSRGLIQEMSGDAS--VCPASS 557 V+L+Q + +R IQ++ G ++ +C ASS Sbjct: 553 VSLYQPQLATRPWIQDIEGASAKDLCSASS 582 >gi|39777608 semaphorin 4B precursor [Homo sapiens] Length = 837 Score = 456 bits (1173), Expect = e-128 Identities = 255/570 (44%), Positives = 355/570 (62%), Gaps = 29/570 (5%) Query: 6 PIRGLLMALAVMFGTAMAFAPIPRITWE--HREVHLVQFHEPDIYNYSALLLSEDKDTLY 63 P+ LL+ L ++ +A PRI+ E ++F I NY+ALLLS D TLY Sbjct: 24 PLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFLRFEAEHISNYTALLLSRDGRTLY 83 Query: 64 IGAREAVFAVNALNIS----EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS 119 +GAREA+FA+++ N+S + E+ W +KK +C+ KGK Q +C NYI++L PLS Sbjct: 84 VGAREALFALSS-NLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRDCQNYIKILLPLS 142 Query: 120 ATSLYVCGTNAFQPACDHLNLTSFKFLGKN------EDGKGRCPFDPAHSYTSVMVDGEL 173 + L+ CGT AF P C ++N+ +F EDGKGRCPFDP T+++VDGEL Sbjct: 143 GSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPNFKSTALVVDGEL 202 Query: 174 YSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYF 233 Y+GT +F G++P ISR+ S P +TE ++ WL +P+FV + I +S S G+DD++YF Sbjct: 203 YTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAFVASAYIPESLGSLQGDDDKIYF 262 Query: 234 FFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVL 293 FF+E E+EF ++ RIAR+CKGD+GG R LQ++WTSFLKA+L+CSRPD G FNVL Sbjct: 263 FFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVL 322 Query: 294 RDVFVLR-SP-GLKVPVFYALFTPQLN--NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349 +DVF L SP + +FY +FT Q + SAVC + + + VFS G Y + V Sbjct: 323 QDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKDVQRVFS-GLYKE---VN 378 Query: 350 QSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409 + +W PVP PRPGACI + AR SSL LPD+ L F+KDH LMD V + Sbjct: 379 RETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKDHFLMDGQVR---S 435 Query: 410 RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQD 469 R L++ Y ++ V R L T YDV+F+ T G LHKA+S+ VHIIEE Q+F Sbjct: 436 RMLLLQPQARYQRVAVHRVPGLHHT-YDVLFLGTGDGRLHKAVSVGPRVHIIEELQIFSS 494 Query: 470 FEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATC 529 +PVQ LLL + +G +YA S+SGVVQ P+A C + +C DC+LARDPYCAWS + Sbjct: 495 GQPVQNLLLDTHRG--LLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYCAWSGSSCKH 552 Query: 530 VALHQTESPSRGLIQEMSGDAS--VCPASS 557 V+L+Q + +R IQ++ G ++ +C ASS Sbjct: 553 VSLYQPQLATRPWIQDIEGASAKDLCSASS 582 >gi|28872814 semaphorin 4G [Homo sapiens] Length = 843 Score = 411 bits (1057), Expect = e-114 Identities = 227/551 (41%), Positives = 327/551 (59%), Gaps = 25/551 (4%) Query: 28 PRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQH-EVY 86 PR+T + E+ + + NYS LLL E L +GAR A+F+++A +I + H E++ Sbjct: 34 PRMTIPYEELSGTRHFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDIGDGAHKEIH 93 Query: 87 WKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFL 146 W+ S + ++KC +KGK+ QTEC N++R LQ L++T LY CGT+AFQP C ++ +F Sbjct: 94 WEASPEMQSKCHQKGKNNQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAEAFTLP 153 Query: 147 GKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSPLRTEYA-IPW 205 E+GK +CP+DPA +T +++DG LY+ T Y F S P I R+ LRTE + W Sbjct: 154 TSFEEGKEKCPYDPARGFTGLIIDGGLYTATRYEF-RSIPDIRRSRHPHSLRTEETPMHW 212 Query: 206 LNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVE------YEFVFRVLIPRIARVCKG 259 LN+ FVF+ ++R+S S G+DD+VY+FFTE + E + + R+ARVCKG Sbjct: 213 LNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKG 272 Query: 260 DQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFT--PQL 317 D GG + LQKKWTSFLKARLIC P ++ LR V L + FYA FT Q Sbjct: 273 DLGGKKILQKKWTSFLKARLICHIP----LYETLRGVCSLDAETSSRTHFYAAFTLSTQW 328 Query: 318 NNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARA 377 + SA+C Y+L+ + VF+ G YM+ + +W RY G VP+PRPG+CI R+ Sbjct: 329 KTLEASAICRYDLAEIQAVFA-GPYME---YQDGSRRWGRYEGGVPEPRPGSCITDSLRS 384 Query: 378 ANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYD 437 Y SS +LP L FVK HPLM V P RP L+K+++ YT + G YD Sbjct: 385 QGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTPAGPTYD 444 Query: 438 VMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQ 497 ++F+ T G +HKA+ L +HIIEETQ+F++ + V+ L++S + + +Y G+ SGV+Q Sbjct: 445 LLFLGTADGWIHKAVVLGSGMHIIEETQVFRESQSVENLVISLLQHS--LYVGAPSGVIQ 502 Query: 498 APLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRG----LIQEMSGDASVC 553 PL+ C ++ +C DC+LARDPYC W P T C A + S+G LIQ++ C Sbjct: 503 LPLSSCSRYRSCYDCILARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDIERGNRGC 562 Query: 554 PASSPKPLPPP 564 +S PPP Sbjct: 563 ESSRDTGPPPP 573 >gi|19923279 semaphorin W [Homo sapiens] Length = 770 Score = 379 bits (972), Expect = e-105 Identities = 210/553 (37%), Positives = 320/553 (57%), Gaps = 20/553 (3%) Query: 11 LMALAVMFGTAMAFAP--IPRITWEHREVH--LVQFHEPDIYNYSALLLSEDKDTLYIGA 66 L+ LAV+ G P +PR + E L +F P YNYS LL+ TLY+GA Sbjct: 22 LLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGA 81 Query: 67 REAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVC 126 R+ +FA++ E+ + W V E + C +KGK K+ EC N++++L +A+ L C Sbjct: 82 RDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGK-KEDECHNFVQILAIANASHLLTC 140 Query: 127 GTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEP 186 GT AF P C ++++ F+ + + E G+G+CPF+PA +VM G LY+ T N+LG+EP Sbjct: 141 GTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEP 200 Query: 187 IISRNSSHSP--LRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEF 244 II+R + +RT+ WLN P+FV A + + + DD +YFFFTE S ++ Sbjct: 201 IITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDS 260 Query: 245 VFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSP-G 303 R+ +PR+ARVC GD GG +TLQ++WT+FLKA L+C P+ G +VL+DV VLR G Sbjct: 261 YERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELG 320 Query: 304 LKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVP 363 P+FY +F+ Q +SAVCA+ V + G + + + + VP Sbjct: 321 AGTPIFYGIFSSQWEGATISAVCAFRPQDIRTVLN-GPFRELK--HDCNRGLPVVDNDVP 377 Query: 364 KPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQI 423 +PRPG CI + + ++ SSL+LPD+ L F++DHPLMD V P D P L+ D Y ++ Sbjct: 378 QPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLVTTDTAYLRV 437 Query: 424 VVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKG 483 V R +L G YDV+++ T+ G LH+A+ + + ++E+ LF + +PV+ + K Sbjct: 438 VAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENM----KLY 493 Query: 484 NRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLI 543 + ++ GS + V Q CG+ +C +C+LA+DP CAWS CVA H E RGL+ Sbjct: 494 HSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDECVA-HAGE--HRGLV 550 Query: 544 QEM-SGD-ASVCP 554 Q++ S D +S+CP Sbjct: 551 QDIESADVSSLCP 563 >gi|21361914 semaphorin B [Homo sapiens] Length = 761 Score = 376 bits (965), Expect = e-104 Identities = 221/522 (42%), Positives = 309/522 (59%), Gaps = 48/522 (9%) Query: 26 PIPRITW----EHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALN--IS 79 P+PR+ + E R + FH+ + ++ LLLS D +TLY+GAREA+ A++ + + Sbjct: 38 PMPRVRYYAGDERRALSF--FHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVP 95 Query: 80 EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLN 139 ++ + W S+ KK++CA K KS +T+C N+IRVL + T LY CGT AF PAC + Sbjct: 96 RLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIE 155 Query: 140 LTSFKFLGKNED----GKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHS 195 L L +ED GKG+ PFDPAH +T+V+VDG LYSGT NFLGSEPI+ R Sbjct: 156 LQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQ 215 Query: 196 P-LRTEYAIPWLN-EPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRI 253 P L+T+ + WL+ + SFV A P + VYFFF E + E++F R+ R+ Sbjct: 216 PVLKTDNFLRWLHHDASFVAA-----IPST-----QVVYFFFEETASEFDFFERLHTSRV 265 Query: 254 ARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALF 313 ARVCK D GG + LQKKWT+FLKA+L+C++P L FNV+R +L + P YA+F Sbjct: 266 ARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQ-LPFNVIRHAVLLPADSPTAPHIYAVF 324 Query: 314 TP--QLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACI 371 T Q+ SAVCA++L E VF GKY + + + ++W Y GP PRPG+C Sbjct: 325 TSQWQVGGTRSSAVCAFSLLDIERVFK-GKYKE---LNKETSRWTTYRGPETNPRPGSCS 380 Query: 372 DSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQAL 431 + DK L F+KDH LMD+ V P L+K V YT++ V+ Q L Sbjct: 381 VGPS-----------SDKALTFMKDHFLMDEQVV---GTPLLVKSGVEYTRLAVETAQGL 426 Query: 432 DGTVYDVMFVSTDRGALHKA-ISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAG 490 DG + VM++ T G+LHKA +S + + H++EE QLF D EPV+ L L+ +G V+ G Sbjct: 427 DGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQG--AVFVG 484 Query: 491 SNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVAL 532 + GV + P A C + +C DCVLARDP+CAW P + TC L Sbjct: 485 FSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLL 526 >gi|5174673 semaphorin 3A precursor [Homo sapiens] Length = 771 Score = 342 bits (877), Expect = 7e-94 Identities = 205/522 (39%), Positives = 304/522 (58%), Gaps = 39/522 (7%) Query: 27 IPRITWEHREV----HLVQFHE-PDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEK 81 +PR+ ++E+ +++ F+ + +Y LL E++ LY+GA++ +F+ + +NI + Sbjct: 29 VPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVNIKDF 88 Query: 82 QHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNL- 140 Q ++ W VS ++ +C GK EC N+I+VL+ + T LY CGT AF P C ++ + Sbjct: 89 Q-KIVWPVSYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIG 147 Query: 141 -----TSFKFLGKN-EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SS 193 FK + E+G+G+ P+DP S+++DGELYSGT+ +F+G + I R Sbjct: 148 HHPEDNIFKLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGH 207 Query: 194 HSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPR 252 H P+RTE + WLN+P F+ A +I +S D+P EDD+VYFFF E +++ E + R Sbjct: 208 HHPIRTEQHDSRWLNDPKFISAHLISES-DNP--EDDKVYFFFRENAIDGEHSGKATHAR 264 Query: 253 IARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVF 309 I ++CK D GG R+L KWT+FLKARLICS P + F+ L+DVF++ K PV Sbjct: 265 IGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVV 324 Query: 310 YALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGA 369 Y +FT N SAVC Y++S VF G Y + + +WV Y G VP PRPG Sbjct: 325 YGVFTTSSNIFKGSAVCMYSMSDVRRVFL-GPYAHR---DGPNYQWVPYQGRVPYPRPGT 380 Query: 370 CIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDR 427 C + S+ +LPD + F + HP M + V P++NRP +IK DVNY TQIVVDR Sbjct: 381 C--PSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDR 438 Query: 428 TQALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEETQLFQDFEPVQTLLLSSK 481 A DG YDVMF+ TD G + K +S+ ++EE +F++ + + LS+K Sbjct: 439 VDAEDGQ-YDVMFIGTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTK 497 Query: 482 KGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAW 522 + + +Y GS +GV Q PL C +G C +C LARDPYCAW Sbjct: 498 Q--QQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAW 537 >gi|5454048 semaphorin 3C [Homo sapiens] Length = 751 Score = 331 bits (848), Expect = 2e-90 Identities = 196/499 (39%), Positives = 285/499 (57%), Gaps = 32/499 (6%) Query: 43 HEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGK 102 H P +Y LL+ ED+D +Y+G+++ + ++N NIS++ V+W S K +C GK Sbjct: 49 HHP--LDYRILLMDEDQDRIYVGSKDHILSLNINNISQEALSVFWPASTIKVEECKMAGK 106 Query: 103 SKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNL------TSFKFLGKNEDGKGRC 156 C N++RV+Q + T LYVCG+ AF P C +LN F K E GKGRC Sbjct: 107 DPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCESGKGRC 166 Query: 157 PFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFA 214 F+P + SVM++ EL+SG +F+G++ I R+ + + +RT ++ WL+EP FV A Sbjct: 167 SFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWLSEPMFVDA 226 Query: 215 DVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSF 274 VI PD D D +VYFFF E + + + IAR+C D GGLR+L KWT+F Sbjct: 227 HVI---PDGTDPNDAKVYFFFKEKLTDNNRSTKQIHSMIARICPNDTGGLRSLVNKWTTF 283 Query: 275 LKARLICSRPDSG---LVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLS 331 LKARL+CS D F+ L DVF+L + + + Y +FT + SAVC Y+LS Sbjct: 284 LKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHLS 343 Query: 332 TAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTL 391 + VF +G + E + + + Y G +P PRPG C A N ++ PD + Sbjct: 344 DIQTVF-NGPFAHK---EGPNHQLISYQGRIPYPRPGTC-PGGAFTPNMRTTKEFPDDVV 398 Query: 392 QFVKDHPLMDDSVTPIDNRPRLIK--KDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALH 449 F+++HPLM +S+ PI RP +++ D YT+I VDR A DG Y V+F+ TDRG + Sbjct: 399 TFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVDRVNAADGR-YHVLFLGTDRGTVQ 457 Query: 450 KAISL--EHAVH---IIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCG 504 K + L ++V I+EE ++F++ P+ T+ +SSKK + +Y SN GV Q L C Sbjct: 458 KVVVLPTNNSVSGELILEELEVFKNHAPITTMKISSKK--QQLYVSSNEGVSQVSLHRCH 515 Query: 505 KHGT-CEDCVLARDPYCAW 522 +GT C DC LARDPYCAW Sbjct: 516 IYGTACADCCLARDPYCAW 534 >gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens] Length = 749 Score = 323 bits (827), Expect = 5e-88 Identities = 210/579 (36%), Positives = 309/579 (53%), Gaps = 40/579 (6%) Query: 7 IRGLLMALAVMFGTAMAFAPIPRITWEHREVH--LVQFHEPDIYNYSALLLSEDKDTLYI 64 I GL + AV G+A P R++++ + L F Y ALL+ E++ L++ Sbjct: 10 IPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFV 69 Query: 65 GAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLY 124 GA V ++N NIS++ ++ W + + +C GK TEC+N++++L + T L Sbjct: 70 GAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLL 129 Query: 125 VCGTNAFQPACDHLNL---TSFKFL----GKNEDGKGRCPFDPAHSYTSVMVDGELYSGT 177 CGT AF P C + + L G+ EDGKG+ P+DP H SV+V ELYSG Sbjct: 130 ACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGV 189 Query: 178 SYNFLGSEPIISRNSSHSP-LRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFF 235 + + +G + I R+ P LRTE + WLNEP FV I P+S + +DD++YFFF Sbjct: 190 AADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWI---PESENPDDDKIYFFF 246 Query: 236 TEVSVE-YEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP--DSGLVFNV 292 E +VE + R+ + R+ ++C+ D GG R+L KWT+FLKARL+CS P + F+ Sbjct: 247 RETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQ 306 Query: 293 LRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSH 352 L+DVF+L S + P+ YA+F+ + SAVC Y+++ F G + E Sbjct: 307 LQDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFL-GPFAHK---EGPM 362 Query: 353 TKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPR 412 +WV Y G VP PRPG C ++S+ + PD +QF ++HPLM +SV P RP Sbjct: 363 HQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 420 Query: 413 LIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEET 464 ++ NY TQI DR A DG YDV+F+ TD G + K IS+ ++EE Sbjct: 421 FLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEEL 479 Query: 465 QLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAWS 523 +F+D V ++ +SSK+ +Y S S V Q L C HG C +C LARDPYCAW Sbjct: 480 HVFEDSAAVTSMQISSKRHQ--LYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWD 537 Query: 524 PPTATCVALHQTESPSRGLIQEM-SGDAS-VCPASSPKP 560 T Q + R Q++ +GD S +C S +P Sbjct: 538 GVACT---RFQPSAKRRFRRQDVRNGDPSTLCSGDSSRP 573 >gi|41406086 semaphorin 3D [Homo sapiens] Length = 777 Score = 322 bits (826), Expect = 6e-88 Identities = 200/548 (36%), Positives = 300/548 (54%), Gaps = 47/548 (8%) Query: 11 LMALAVMFGTAMAFAP--------IPRITWEHREVHLVQFHEPDI-----YNYSALLLSE 57 L +M M F P IPR+ ++++ L P + ++ LLL E Sbjct: 18 LFPALMMLSMTMLFLPVTGTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDE 77 Query: 58 DKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQP 117 ++ L +GA++ +F ++ +++++ ++YW ++++ C GK TEC N+IRVLQP Sbjct: 78 ERGRLLLGAKDHIFLLSLVDLNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQP 137 Query: 118 LSATSLYVCGTNAFQPACDHLNL------TSFKFLGKN-EDGKGRCPFDPAHSYTSVMVD 170 + T +YVCGT AF P C +++L FK N E G+ +CPFDP + SVM D Sbjct: 138 YNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMTD 197 Query: 171 GELYSGTSYNFLGSEPIISRN----SSHSPLRTEYAIP-WLNEPSFVFADVIRKSPDSPD 225 LYSGT+ +FLG + +R+ H +RT+ + WLN F+ I PD+ + Sbjct: 198 EYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFI---PDTYN 254 Query: 226 GEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPD 285 +DD++YFFF E S E + ++ R+ RVCK D GG R+L KWT+FLKARLICS P Sbjct: 255 PDDDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPG 314 Query: 286 S---GLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKY 342 S F+ L+D+++L + + PV Y +FT + SAVC Y+++ VF +G Y Sbjct: 315 SDGADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVF-NGPY 373 Query: 343 MQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDD 402 E + +WV+Y+G +P PRPG C S+ S+ + PD + F+K H +M Sbjct: 374 AHK---ESADHRWVQYDGRIPYPRPGTC-PSKTYDPLIKSTRDFPDDVISFIKRHSVMYK 429 Query: 403 SVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH- 459 SV P+ P + +V+Y TQIVVD A DG YDVMF+ TD G + K +S+ Sbjct: 430 SVYPVAGGPTFKRINVDYRLTQIVVDHVIAEDGQ-YDVMFLGTDIGTVLKVVSISKEKWN 488 Query: 460 ----IIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVL 514 ++EE Q+F+ + + LS K+ + +Y GS G+VQ L C +G C DC L Sbjct: 489 MEEVVLEELQIFKHSSIILNMELSLKQ--QQLYIGSRDGLVQLSLHRCDTYGKACADCCL 546 Query: 515 ARDPYCAW 522 ARDPYCAW Sbjct: 547 ARDPYCAW 554 >gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens] Length = 748 Score = 321 bits (822), Expect = 2e-87 Identities = 211/579 (36%), Positives = 309/579 (53%), Gaps = 41/579 (7%) Query: 7 IRGLLMALAVMFGTAMAFAPIPRITWEHREVH--LVQFHEPDIYNYSALLLSEDKDTLYI 64 I GL + AV G+A P R++++ + L F Y ALL+ E++ L++ Sbjct: 10 IPGLALLWAVGLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFV 69 Query: 65 GAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLY 124 GA V ++N NIS++ ++ W + + +C GK TEC+N++++L + T L Sbjct: 70 GAENHVASLNLDNISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLL 129 Query: 125 VCGTNAFQPACDHLNL---TSFKFL----GKNEDGKGRCPFDPAHSYTSVMVDGELYSGT 177 CGT AF P C + + L G+ EDGKG+ P+DP H SV+V ELYSG Sbjct: 130 ACGTGAFHPTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGV 189 Query: 178 SYNFLGSEPIISRNSSHSP-LRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFF 235 + + +G + I R+ P LRTE + WLNEP FV I P+S + +DD++YFFF Sbjct: 190 AADLMGRDFTIFRSLGQRPSLRTEPHDSRWLNEPKFVKVFWI---PESENPDDDKIYFFF 246 Query: 236 TEVSVE-YEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP--DSGLVFNV 292 E +VE + R+ + R+ ++C+ D GG R+L KWT+FLKARL+CS P + F+ Sbjct: 247 RETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQ 306 Query: 293 LRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSH 352 L+DVF+L S + P+ YA+F+ G SAVC Y+++ F G + E Sbjct: 307 LQDVFLLSSRDHRTPLLYAVFSTSSIFQG-SAVCVYSMNDVRRAFL-GPFAHK---EGPM 361 Query: 353 TKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPR 412 +WV Y G VP PRPG C ++S+ + PD +QF ++HPLM +SV P RP Sbjct: 362 HQWVSYQGRVPYPRPGMC--PSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPL 419 Query: 413 LIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEET 464 ++ NY TQI DR A DG YDV+F+ TD G + K IS+ ++EE Sbjct: 420 FLQVGANYTFTQIAADRVAAADGH-YDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEEL 478 Query: 465 QLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAWS 523 +F+D V ++ +SSK+ +Y S S V Q L C HG C +C LARDPYCAW Sbjct: 479 HVFEDSAAVTSMQISSKRHQ--LYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWD 536 Query: 524 PPTATCVALHQTESPSRGLIQEM-SGDAS-VCPASSPKP 560 T Q + R Q++ +GD S +C S +P Sbjct: 537 GVACT---RFQPSAKRRFRRQDVRNGDPSTLCSGDSSRP 572 >gi|6912650 semaphorin 3E [Homo sapiens] Length = 775 Score = 309 bits (791), Expect = 7e-84 Identities = 191/521 (36%), Positives = 284/521 (54%), Gaps = 38/521 (7%) Query: 28 PRITWEHREVHLVQ----FHEP-DIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQ 82 PR+ H+E+ + FH P + +LL E ++ L++G R+ V++++ IS+ Sbjct: 31 PRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLSLERISDGY 90 Query: 83 HEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACD------ 136 E++W + K +C KGK EC NY+RVL + T L CGT AF P C Sbjct: 91 KEIHWPSTALKMEECIMKGKDAG-ECANYVRVLHHYNRTHLLTCGTGAFDPVCAFIRVGY 149 Query: 137 HLNLTSFKFLG-KNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSH- 194 HL F ++E G+GRCPFDP+ S+ S ++ EL++G ++ + I R+ Sbjct: 150 HLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLYSDYWSRDAAIFRSMGRL 209 Query: 195 SPLRTEYAIP-WLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRI 253 + +RTE+ L EP FV + +I PD+ D +D++VYFFFTE ++E E + R+ Sbjct: 210 AHIRTEHDDERLLKEPKFVGSYMI---PDNEDRDDNKVYFFFTEKALEAENNAHAIYTRV 266 Query: 254 ARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVFY 310 R+C D GG R L KW++FLKARL+CS P + F+ L DVF+L + K PV + Sbjct: 267 GRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTRDHKNPVIF 326 Query: 311 ALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGAC 370 LF N A+C Y++S+ F +G Y E W Y G VP PRPG+C Sbjct: 327 GLFNTTSNIFRGHAICVYHMSSIRAAF-NGPYAHK---EGPEYHWSVYEGKVPYPRPGSC 382 Query: 371 IDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYT--QIVVDRT 428 S+ Y ++ + PD ++F + HPLM ++ P +P L+K D Y QI VDR Sbjct: 383 A-SKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVDRV 441 Query: 429 QALDGTVYDVMFVSTDRGALHKAISLEHAVH------IIEETQLFQDFEPVQTLLLSSKK 482 +A DG YDV+F+ TD G + K I++ + I+EE Q+F+D P+ ++ +SSK+ Sbjct: 442 EAEDGQ-YDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPVPIISMEISSKR 500 Query: 483 GNRFVYAGSNSGVVQAPLAFCGKHGT-CEDCVLARDPYCAW 522 + +Y GS S V Q C +G+ C DC LARDPYCAW Sbjct: 501 --QQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAW 539 >gi|188497703 semaphorin 3F [Homo sapiens] Length = 785 Score = 299 bits (765), Expect = 7e-81 Identities = 181/525 (34%), Positives = 281/525 (53%), Gaps = 63/525 (12%) Query: 49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTEC 108 +Y LL ED D +Y+G+++ V +++ +I+ + ++W S + +C GK EC Sbjct: 56 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGEC 115 Query: 109 LNYIRVLQPLSATSLYVCGTNAFQPACDHLN------------LTSFKFLGKN------- 149 N++R++QP + T LYVCGT A+ P C ++N + + G Sbjct: 116 GNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALR 175 Query: 150 -------------------EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISR 190 E GKG+CP+DP S +++ ELY+G +F+G++ I R Sbjct: 176 PMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFR 235 Query: 191 N-SSHSPLRTE-YAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRV 248 + +RT+ Y WLN+PSF+ A++I PDS + DD++YFFF E S E Sbjct: 236 TLGKQTAMRTDQYNSRWLNDPSFIHAELI---PDSAERNDDKLYFFFRERSAEAP-QSPA 291 Query: 249 LIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLK 305 + RI R+C D GG L KW++FLKARL+CS P + F+ L+DVFV ++ ++ Sbjct: 292 VYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR 351 Query: 306 VPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKP 365 PV YA+FT + SAVC Y+++ VF +G + E + +W+ ++G +P P Sbjct: 352 NPVIYAVFTSSGSVFRGSAVCVYSMADIRMVF-NGPFAHK---EGPNYQWMPFSGKMPYP 407 Query: 366 RPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQI 423 RPG C + S+ + PD+ + F++ HPLM +V P+ RP +++ Y T I Sbjct: 408 RPGTC-PGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTI 466 Query: 424 VVDRTQALDGTVYDVMFVSTDRGALHKAISL-----EHAVHIIEETQLFQDFEPVQTLLL 478 VD+ A DG Y+V+F+ TDRG + K I L E ++EE ++F+D PV+T+ + Sbjct: 467 AVDQVDAADGR-YEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTI 525 Query: 479 SSKKGNRFVYAGSNSGVVQAPLAFCGKHG-TCEDCVLARDPYCAW 522 SSK+ + +Y S GV L C +G C DC LARDPYCAW Sbjct: 526 SSKR--QQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAW 568 >gi|9910362 semaphorin sem2 [Homo sapiens] Length = 782 Score = 297 bits (761), Expect = 2e-80 Identities = 189/502 (37%), Positives = 269/502 (53%), Gaps = 32/502 (6%) Query: 49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTEC 108 N A+ L E +D L++G +A++++ EV W ++ +C KG+ TEC Sbjct: 57 NLQAMYLDEYRDRLFLGGLDALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTEC 116 Query: 109 LNYIRVLQPLSATSLYVCGTNAFQPACDHLNL------TSFKFLGKNEDGKGRCPFDPAH 162 N++RVLQP + T L CGT AFQP C + + G E G+GRCP +P+ Sbjct: 117 ANFVRVLQPHNRTHLLACGTGAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSR 176 Query: 163 SYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-LRTEYAIPWLNEPSFVFADVIRKSP 221 + S +DGELY+G + +FLG E +I R+ P LR++ L++P FV A + P Sbjct: 177 PFASTFIDGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQSLLHDPRFVMA---ARIP 233 Query: 222 DSPDGEDDRVYFFFTE-VSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLI 280 ++ D ++D+VYFFF+E V V + R+ RVC D GG R L KW++FLKARL+ Sbjct: 234 ENSDQDNDKVYFFFSETVPSPDGGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLV 293 Query: 281 CSRPDSG---LVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVF 337 CS P G F+ L DVF+L K YALF+ AVC Y+++ EVF Sbjct: 294 CSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSAVFQGFAVCVYHMADIWEVF 353 Query: 338 SHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAAN--YTSSLNLPDKTLQFVK 395 +G + + +W Y G VP PRPG C + S+ + PD+ LQF + Sbjct: 354 -NGPFAHR---DGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFAR 409 Query: 396 DHPLMDDSVTPIDNRPRLIKKDV--NYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAIS 453 HPLM V P RP L+K + QIVVDR +A DGT YDV+F+ TD G++ K I+ Sbjct: 410 AHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVDRVEAEDGT-YDVIFLGTDSGSVLKVIA 468 Query: 454 L------EHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHG 507 L E ++EE Q+F+ P+ + +S K+ + +Y GS GV Q L C +G Sbjct: 469 LQAGGSAEPEEVVLEELQVFKVPTPITEMEISVKR--QMLYVGSRLGVAQLRLHQCETYG 526 Query: 508 T-CEDCVLARDPYCAWSPPTAT 528 T C +C LARDPYCAW + T Sbjct: 527 TACAECCLARDPYCAWDGASCT 548 >gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens] Length = 1011 Score = 281 bits (718), Expect = 2e-75 Identities = 177/494 (35%), Positives = 275/494 (55%), Gaps = 44/494 (8%) Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109 L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119 Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169 N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++ Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179 Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227 DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229 Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285 + VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289 Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344 S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ + Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346 Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404 T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403 Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAI------SLEH 456 PI + P K V Y T I VD + A Y V+FV ++ G + K + SL Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLND 462 Query: 457 AVHIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC 509 +V ++EE + + ++ E + + L K + +Y +S +++ PL+ C ++G+C Sbjct: 463 SV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSC 521 Query: 510 -EDCVLARDPYCAW 522 + C+ +RDPYC W Sbjct: 522 KKSCIASRDPYCGW 535 >gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens] Length = 597 Score = 281 bits (718), Expect = 2e-75 Identities = 177/494 (35%), Positives = 275/494 (55%), Gaps = 44/494 (8%) Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109 L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119 Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169 N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++ Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179 Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227 DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229 Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285 + VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289 Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344 S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ + Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346 Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404 T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403 Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAI------SLEH 456 PI + P K V Y T I VD + A Y V+FV ++ G + K + SL Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLND 462 Query: 457 AVHIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC 509 +V ++EE + + ++ E + + L K + +Y +S +++ PL+ C ++G+C Sbjct: 463 SV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSC 521 Query: 510 -EDCVLARDPYCAW 522 + C+ +RDPYC W Sbjct: 522 KKSCIASRDPYCGW 535 >gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens] Length = 1073 Score = 281 bits (718), Expect = 2e-75 Identities = 177/494 (35%), Positives = 275/494 (55%), Gaps = 44/494 (8%) Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109 L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119 Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169 N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++ Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179 Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227 DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229 Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285 + VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289 Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344 S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ + Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346 Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404 T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403 Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAI------SLEH 456 PI + P K V Y T I VD + A Y V+FV ++ G + K + SL Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLND 462 Query: 457 AVHIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC 509 +V ++EE + + ++ E + + L K + +Y +S +++ PL+ C ++G+C Sbjct: 463 SV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSC 521 Query: 510 -EDCVLARDPYCAW 522 + C+ +RDPYC W Sbjct: 522 KKSCIASRDPYCGW 535 >gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens] Length = 1017 Score = 281 bits (718), Expect = 2e-75 Identities = 177/494 (35%), Positives = 275/494 (55%), Gaps = 44/494 (8%) Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109 L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119 Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169 N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++ Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179 Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227 DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229 Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285 + VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289 Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344 S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ + Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346 Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404 T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403 Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAI------SLEH 456 PI + P K V Y T I VD + A Y V+FV ++ G + K + SL Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLND 462 Query: 457 AVHIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC 509 +V ++EE + + ++ E + + L K + +Y +S +++ PL+ C ++G+C Sbjct: 463 SV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSC 521 Query: 510 -EDCVLARDPYCAW 522 + C+ +RDPYC W Sbjct: 522 KKSCIASRDPYCGW 535 >gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens] Length = 998 Score = 281 bits (718), Expect = 2e-75 Identities = 177/494 (35%), Positives = 275/494 (55%), Gaps = 44/494 (8%) Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109 L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119 Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169 N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++ Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179 Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227 DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229 Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285 + VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289 Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344 S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ + Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346 Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404 T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403 Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAI------SLEH 456 PI + P K V Y T I VD + A Y V+FV ++ G + K + SL Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLND 462 Query: 457 AVHIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC 509 +V ++EE + + ++ E + + L K + +Y +S +++ PL+ C ++G+C Sbjct: 463 SV-LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSC 521 Query: 510 -EDCVLARDPYCAW 522 + C+ +RDPYC W Sbjct: 522 KKSCIASRDPYCGW 535 >gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A [Homo sapiens] Length = 1030 Score = 268 bits (684), Expect = 2e-71 Identities = 178/496 (35%), Positives = 267/496 (53%), Gaps = 47/496 (9%) Query: 61 TLYIGAREAVFAVNALNISEKQHEVY------WKVSEDKKAKCAEKGKSKQTECLNYIRV 114 TLYI AR+ ++ V+ ++ S + E+Y WK + C KGK K EC N+I+V Sbjct: 67 TLYIAARDHIYTVD-IDTSHTE-EIYCSKKLTWKSRQADVDTCRMKGKHKD-ECHNFIKV 123 Query: 115 LQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELY 174 L + +L+VCGTNAF P+C + + + + G G RCP+D H+ ++ DG+LY Sbjct: 124 LLKKNDDALFVCGTNAFNPSCRNYKMDTLEPFGDEFSGMARCPYDAKHANVALFADGKLY 183 Query: 175 SGTSYNFLGSEPIISRNSSHSP-LRT-EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVY 232 S T +FL + +I R+ SP LRT ++ WL EP FV A D +Y Sbjct: 184 SATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQA----------VDYGDYIY 233 Query: 233 FFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-DSGLVF 290 FFF E++VEY + +V+ PR+A+VCK D GG R L+K+WTSFLKARL CS P DS F Sbjct: 234 FFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYF 293 Query: 291 NVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVE 349 N+L+ V V+R G V + A F+ N++ SAVCAY++ VF+ G++ + + + Sbjct: 294 NILQAVTDVIRINGRDVVL--ATFSTPYNSIPGSAVCAYDMLDIASVFT-GRFKEQKSPD 350 Query: 350 QSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409 + T + VPKPRPG C S + Y +S PD TL F+K HPLMD++V I N Sbjct: 351 STWTPVP--DERVPKPRPGCCAGSSS-LERYATSNEFPDDTLNFIKTHPLMDEAVPSIFN 407 Query: 410 RPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGA-------------LHKAISL 454 RP ++ V Y T+I VD T A + V+F+ +++G L+ ++ L Sbjct: 408 RPWFLRTMVRYRLTKIAVD-TAAGPYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFL 466 Query: 455 EHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC-EDCV 513 E E + E + + + + + +Y ++ V++ PL C +HG C + C+ Sbjct: 467 EEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCI 526 Query: 514 LARDPYCAWSPPTATC 529 +RDPYC W C Sbjct: 527 ASRDPYCGWIKEGGAC 542 >gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] Length = 1151 Score = 261 bits (668), Expect = 1e-69 Identities = 192/605 (31%), Positives = 294/605 (48%), Gaps = 73/605 (12%) Query: 23 AFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQ 82 A + P + +E + + F P ++S L L + L +GAR +F ++ N+S Q Sbjct: 99 ALSKHPTVAFEDLQPWVSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVSLLQ 158 Query: 83 HEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTS 142 W SED + C KGK+++ EC NY+RVL ++ +++CGTNAF P C + + Sbjct: 159 -ATEWASSEDTRRSCQSKGKTEE-ECQNYVRVLI-VAGRKVFMCGTNAFSPMCTSRQVGN 215 Query: 143 FKFLGKNEDGKGRCPFDPAHSYTSVMVD-GELYSGTSYNFLGSEPIISRN-SSHSPLRT- 199 + +G RCP+DP H+ T+V+ GELY+ T +F G +P I R+ S PLRT Sbjct: 216 LSRTIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTA 275 Query: 200 EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKG 259 +Y WLNEP+FV A I YFF E +VE++ R + R+ARVCK Sbjct: 276 QYNSKWLNEPNFVAAYDIGLF----------AYFFLRENAVEHD-CGRTVYSRVARVCKN 324 Query: 260 DQGGLRTLQKKWTSFLKARLICSRP-DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLN 318 D GG L+ WT+F+KARL CSRP + +N L+ F L L Y +FT +N Sbjct: 325 DVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDL----IYGVFTTNVN 380 Query: 319 NVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAA 378 ++ SAVCA+NLS + F+ Q E W+ P+P + G ++ Sbjct: 381 SIAASAVCAFNLSAISQAFNGPFRYQ----ENPRAAWLPIANPIPNFQCGTLPETGPNE- 435 Query: 379 NYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDV 438 NL +++LQ + LM ++V P+ P + + V ++ +VVD QA D T+Y V Sbjct: 436 ------NLTERSLQDAQRLFLMSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKD-TLYHV 488 Query: 439 MFVSTDRGALHKAIS-LEHAVH--IIEETQLFQD--FEPVQTLLLSSKKGNRFVYAGSNS 493 +++ T+ G + KA+S ++H +EE + EP+++L + R ++ G Sbjct: 489 LYIGTESGTILKALSTASRSLHGCYLEELHVLPPGRREPLRSLRILHSA--RALFVGLRD 546 Query: 494 GVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQ-----------TESPSRGL 542 GV++ PL C + + C+ ARDPYC W C L T P R + Sbjct: 547 GVLRVPLERCAAYRSQGACLGARDPYCGWDGKQQRCSTLEDSSNMSLWTQNITACPVRNV 606 Query: 543 IQE--------------MSGDAS---VCPASSPKPLPPPGSSSLSCLG---HVGDRRLSS 582 ++ + GD S +C A S P P L CLG H+ + + Sbjct: 607 TRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDS-PRPRCGGLDCLGPAIHIANCSRNG 665 Query: 583 PWTPW 587 WTPW Sbjct: 666 AWTPW 670 >gi|147904700 semaphorin 5A [Homo sapiens] Length = 1074 Score = 249 bits (635), Expect = 8e-66 Identities = 180/569 (31%), Positives = 285/569 (50%), Gaps = 63/569 (11%) Query: 28 PRITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYW 87 P I+++ L +F + ++S L + L +GAR +F + ++S Q V W Sbjct: 36 PVISYKEIGPWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQ-AVEW 94 Query: 88 KVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLG 147 + E K C KGKSK+ EC NYIRVL + L+ CGTNAF P C + +L++ + Sbjct: 95 ECDEATKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNLTEIH 152 Query: 148 KNEDGKGRCPFDPAHSYTSVMV-DGELYSGTSYNFLGSEPIISRNSSH-SPLRT-EYAIP 204 G RCP+ P H+ T+++ GELY+ T+ +F G +P I R+ PLRT +Y Sbjct: 153 DQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSK 212 Query: 205 WLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGL 264 WLNEP+FV + I + YFFF E +VE++ + + R ARVCK D GG Sbjct: 213 WLNEPNFVSSYDI----------GNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGR 261 Query: 265 RTLQKKWTSFLKARLICSRP-DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLS 323 L+ WT+F+KARL CSRP + +N L+ F L ++ + Y +FT +N++ S Sbjct: 262 FLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLP----ELDLIYGIFTTNVNSIAAS 317 Query: 324 AVCAYNLSTAEEVFSHG-KYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTS 382 AVC +NLS + FS KY E S + W+ P P P P + + Sbjct: 318 AVCVFNLSAIAQAFSGPFKYQ-----ENSRSAWL----PYPNPNP----HFQCGTVDQGL 364 Query: 383 SLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVS 442 +NL ++ LQ + LM + V P+ P ++ + ++ + VD Q + V+ +++++ Sbjct: 365 YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVH-IIYLA 423 Query: 443 TDRGALHKA---ISLEHAVHIIEETQLFQD--FEPVQTLLLSSKKGNRFVYAGSNSGVVQ 497 TD G + K ++ + ++EE +LF + EP+++L + + FV G VV+ Sbjct: 424 TDYGTIKKVRVPLNQTSSSCLLEEIELFPERRREPIRSLQILHSQSVLFV--GLREHVVK 481 Query: 498 APLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPASS 557 PL C + T C+ A+DPYC W C +L ++ S + + S CP Sbjct: 482 IPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLS-----MTQWEQSISACP--- 533 Query: 558 PKPLPPPGSSSLSCLGHVGDRRLSSPWTP 586 + +L+ GH G + SPWTP Sbjct: 534 --------TRNLTVDGHFG---VWSPWTP 551 >gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens] Length = 476 Score = 248 bits (634), Expect = 1e-65 Identities = 155/411 (37%), Positives = 232/411 (56%), Gaps = 29/411 (7%) Query: 54 LLSEDKDTLYIGAREAVFAVNALNISEKQ----HEVYWKVSEDKKAKCAEKGKSKQTECL 109 L+ + +DTLYI R+ V+ VN + + + ++ W+ + + CA KGK K EC Sbjct: 61 LMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKD-ECH 119 Query: 110 NYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV 169 N+I+V P + ++VCGTNAF P C + L++ ++ G+ G RCPFD + ++ Sbjct: 120 NFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFA 179 Query: 170 DGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGE 227 DG+LYS T +FL S+ +I R+ S LRT +Y W+ EP F+ A Sbjct: 180 DGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEY---------- 229 Query: 228 DDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-D 285 + VYFFF E++VE+ + + + R+AR+CK D GG R L+K WTSFLKARL CS P D Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289 Query: 286 SGLVFNVLRDVF-VLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344 S F+VL+ + +++ G +P +FT QLN++ SAVCA+++ E+VF G++ + Sbjct: 290 SFFYFDVLQSITDIIQING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFK-GRFKE 346 Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404 T + T VPKPRPG C A Y +S++ PD+TL F+K HPLMD +V Sbjct: 347 QKTPDSVWT--AVPEDKVPKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAV 403 Query: 405 TPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAIS 453 PI + P K V Y T I VD + A Y V+FV ++ G + K ++ Sbjct: 404 PPIADEPWFTKTRVRYRLTAISVDHS-AGPYQNYTVIFVGSEAGMVLKVLA 453 >gi|19718780 semaphorin 6B precursor [Homo sapiens] Length = 888 Score = 234 bits (598), Expect = 2e-61 Identities = 166/500 (33%), Positives = 266/500 (53%), Gaps = 48/500 (9%) Query: 61 TLYIGAREAVFAVNALNISEK----QHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQ 116 TL+IG R+ ++ V + Q ++ W+ + C KGK ++ EC N+++VL Sbjct: 76 TLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMKGK-QEGECRNFVKVLL 134 Query: 117 PLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSG 176 ++L+VCG+NAF P C + ++ + + +G N G RCP+DP H+ ++ DG L++ Sbjct: 135 LRDESTLFVCGSNAFNPVCANYSIDTLQPVGDNISGMARCPYDPKHANVALFSDGMLFTA 194 Query: 177 TSYNFLGSEPIISRNSSHSP-LRT-EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFF 234 T +FL + +I R+ P LRT ++ W EP FV A VYFF Sbjct: 195 TVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHA----------VEWGSHVYFF 244 Query: 235 FTEVSVEYEFVFRVLIPRIARVCKGDQGGL-RTLQKKWTSFLKARLICSRP-DSGLVFNV 292 F E+++E+ ++ +V++ R+ARVCK D GG R L+K+WTSFLKARL CS P DS FNV Sbjct: 245 FREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNV 304 Query: 293 LRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSH 352 L+ V + S G + PV A+F+ N++ SAVCA++L+ VF G++ + + E Sbjct: 305 LQAVTGVVSLGGR-PVVLAVFSTPSNSIPGSAVCAFDLTQVAAVF-EGRFREQKSPESIW 362 Query: 353 TKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPR 412 T VP+PRPG C A Y +S LPD L FVK HPLMD++V + + P Sbjct: 363 TPVP--EDQVPRPRPGCC---AAPGMQYNASSALPDDILNFVKTHPLMDEAVPSLGHAPW 417 Query: 413 LIKKDVNY--TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVH--------IIE 462 +++ + + T++ VD G V+F+ ++ G + K + +A +E Sbjct: 418 ILRTLMRHQLTRVAVDVGAGPWGN-QTVVFLGSEAGTVLKFLVRPNASTSGTSGLSVFLE 476 Query: 463 ETQLFQ--------DFEPVQTLL-LSSKKGNRFVYAGSNSGVVQAPLAFCGKHGTC-EDC 512 E + ++ E Q LL L + + A VV+ P+A C ++ C ++C Sbjct: 477 EFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYSGCMKNC 536 Query: 513 VLARDPYCAWSPPTATCVAL 532 + ++DPYC W+ P +C+ L Sbjct: 537 IGSQDPYCGWA-PDGSCIFL 555 >gi|16306552 semaphorin Y [Homo sapiens] Length = 930 Score = 234 bits (597), Expect = 2e-61 Identities = 174/496 (35%), Positives = 248/496 (50%), Gaps = 62/496 (12%) Query: 61 TLYIGAREAVFAVNALNISEKQHEV-----YWKVSEDKKAKCAEKGKSKQTECLNYIRVL 115 TL + AR+ VF+ + E + V W+ S+D + CA +GK EC NYIRVL Sbjct: 72 TLLVAARDHVFSFDLQAEEEGEGLVPNKYLTWR-SQDVE-NCAVRGKLTD-ECYNYIRVL 128 Query: 116 QPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYS 175 P + +L CGTN+F P C +TS + G+ G+ RCPFD S ++ +G LYS Sbjct: 129 VPWDSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYS 188 Query: 176 GTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYF 233 T+ +F S+ ++ R+ PLR+ +Y WL EP FV A D VYF Sbjct: 189 ATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLREPHFVQALE----------HGDHVYF 238 Query: 234 FFTEVSVEYEFVFRVLIPRIARVCKGDQGGL-RTLQKKWTSFLKARLICSRP-DSGLVFN 291 FF EVSVE + RV R+ARVCK D GG R L + WTSFLK RL CS P DS F+ Sbjct: 239 FFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFYFD 298 Query: 292 VLRDVFVLRSPGLKVPV-------FYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344 VL+ L PV + +FT Q N++ SAVCA+ L E F GK+ + Sbjct: 299 VLQ--------ALTGPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFE-GKFKE 349 Query: 345 STTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSV 404 +++ + T VP PRPG+C AA ++SS +LPD L F+K HPL+D +V Sbjct: 350 QRSLDGAWTPVSEDR--VPSPRPGSCA-GVGGAALFSSSRDLPDDVLTFIKAHPLLDPAV 406 Query: 405 TPIDNRPRL-IKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEE 463 P+ ++P L + TQ+ VD + VMF+ ++ G + K ++ E Sbjct: 407 PPVTHQPLLTLTSRALLTQVAVDGMAGPHSNI-TVMFLGSNDGTVLKVLT-PGGRSGGPE 464 Query: 464 TQLFQDFEPVQTLLLSSKK----------------GNRFVYAGSNSGVVQAPLAFCGKHG 507 L ++ + S K+ G+R A S +V PL+ C +HG Sbjct: 465 PILLEEIDAYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGC-IVYLPLSRCARHG 523 Query: 508 TCE-DCVLARDPYCAW 522 C+ C+ ++DPYC W Sbjct: 524 ACQRSCLASQDPYCGW 539 >gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens] Length = 666 Score = 190 bits (482), Expect = 5e-48 Identities = 155/546 (28%), Positives = 243/546 (44%), Gaps = 77/546 (14%) Query: 29 RITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWK 88 R+ + E H V FHEP ++++G R V+ + K V Sbjct: 66 RVDFGQTEPHTVLFHEPG------------SSSVWVGGRGKVYLFDFPE--GKNASVRTV 111 Query: 89 VSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGK 148 K C +K +C NYI +L+ S L CGTNA P+C +L + LG+ Sbjct: 112 NIGSTKGSCLDK-----RDCENYITLLERRSE-GLLACGTNARHPSCWNLVNGTVVPLGE 165 Query: 149 NEDGKGRCPFDPAHSYTSVMVDGELYSGT-SYNFLGSEPIISRNSSHSPLRTEYAIPWLN 207 +G PF P + + E+YS + G P R S L T + + Sbjct: 166 M---RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQ 220 Query: 208 EPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTL 267 P F+ A ++ + DD++Y+FF E + + + + R+A++C+GDQGG +L Sbjct: 221 NPQFIKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSL 276 Query: 268 Q-KKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPG--LKVPVFYALFTPQLNNVGLSA 324 KW +FLKA L+CS + FN L+DVF+L P + Y +F+ N SA Sbjct: 277 SVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFS---NPWNYSA 333 Query: 325 VCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSL 384 VC Y+L ++VF Y+ +P PRPG C+ + Sbjct: 334 VCVYSLGDIDKVFRTSSLK-------------GYHSSLPNPRPGKCLPDQQ--------- 371 Query: 385 NLPDKTLQFVKDHPLMDDSVTPIDN-RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVST 443 +P +T Q HP + V P+ + L +Y ++ V R QA G + V++++T Sbjct: 372 PIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTT 431 Query: 444 DRGALHKAISLEHAVHI----IEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAP 499 DRG +HK + H I E Q F+ +QT+ L +++ R +Y S V Q P Sbjct: 432 DRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAER--RKLYVSSQWEVSQVP 489 Query: 500 LAFCGKH-GTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPASSP 558 L C + G C C+++RDPYC W C++++ +E R ++Q S+ PA Sbjct: 490 LDLCEVYGGGCHGCLMSRDPYCGWD--QGRCISIYSSE---RSVLQ------SINPAEPH 538 Query: 559 KPLPPP 564 K P P Sbjct: 539 KECPNP 544 >gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens] Length = 652 Score = 190 bits (482), Expect = 5e-48 Identities = 155/546 (28%), Positives = 243/546 (44%), Gaps = 91/546 (16%) Query: 29 RITWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWK 88 R+ + E H V FHEP ++++G R V+ + Sbjct: 66 RVDFGQTEPHTVLFHEP------------GSSSVWVGGRGKVY--------------LFD 99 Query: 89 VSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGK 148 E K A S +T+C NYI +L+ S L CGTNA P+C +L + LG Sbjct: 100 FPEGKNA-------SVRTDCENYITLLERRS-EGLLACGTNARHPSCWNLVNGTVVPLG- 150 Query: 149 NEDGKGRCPFDPAHSYTSVMVDGELYSG-TSYNFLGSEPIISRNSSHSPLRTEYAIPWLN 207 + +G PF P + + E+YS + G P R S L T + + Sbjct: 151 --EMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQ 206 Query: 208 EPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTL 267 P F+ A ++ + DD++Y+FF E + + + + R+A++C+GDQGG +L Sbjct: 207 NPQFIKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSL 262 Query: 268 Q-KKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPG--LKVPVFYALFTPQLNNVGLSA 324 KW +FLKA L+CS + FN L+DVF+L P + Y +F+ N SA Sbjct: 263 SVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFS---NPWNYSA 319 Query: 325 VCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSL 384 VC Y+L ++VF Y+ +P PRPG C+ + Sbjct: 320 VCVYSLGDIDKVFRTSSLK-------------GYHSSLPNPRPGKCLPDQQ--------- 357 Query: 385 NLPDKTLQFVKDHPLMDDSVTPIDN-RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVST 443 +P +T Q HP + V P+ + L +Y ++ V R QA G + V++++T Sbjct: 358 PIPTETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTT 417 Query: 444 DRGALHKAISLEHAVHI----IEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAP 499 DRG +HK + H I E Q F+ +QT+ L +++ R +Y S V Q P Sbjct: 418 DRGTIHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAER--RKLYVSSQWEVSQVP 475 Query: 500 LAFCGKH-GTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPASSP 558 L C + G C C+++RDPYC W C++++ +E R ++Q S+ PA Sbjct: 476 LDLCEVYGGGCHGCLMSRDPYCGWD--QGRCISIYSSE---RSVLQ------SINPAEPH 524 Query: 559 KPLPPP 564 K P P Sbjct: 525 KECPNP 530 >gi|225637524 semaphorin 7A isoform 3 [Homo sapiens] Length = 501 Score = 166 bits (419), Expect = 9e-41 Identities = 122/422 (28%), Positives = 194/422 (45%), Gaps = 54/422 (12%) Query: 153 KGRCPFDPAHSYTSVMVDGELYSGT-SYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSF 211 +G PF P + + E+YS + G P R S L T + + P F Sbjct: 2 RGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTV--MQNPQF 59 Query: 212 VFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQ-KK 270 + A ++ + DD++Y+FF E + + + + R+A++C+GDQGG +L K Sbjct: 60 IKATIVHQD----QAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSK 115 Query: 271 WTSFLKARLICSRPDSGLVFNVLRDVFVLRSPG--LKVPVFYALFTPQLNNVGLSAVCAY 328 W +FLKA L+CS + FN L+DVF+L P + Y +F+ N SAVC Y Sbjct: 116 WNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFS---NPWNYSAVCVY 172 Query: 329 NLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPD 388 +L ++VF Y+ +P PRPG C+ + +P Sbjct: 173 SLGDIDKVFRTSSLK-------------GYHSSLPNPRPGKCLPDQQ---------PIPT 210 Query: 389 KTLQFVKDHPLMDDSVTPIDN-RPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVSTDRGA 447 +T Q HP + V P+ + L +Y ++ V R QA G + V++++TDRG Sbjct: 211 ETFQVADRHPEVAQRVEPMGPLKTPLFHSKYHYQKVAVHRMQASHGETFHVLYLTTDRGT 270 Query: 448 LHKAISLEHAVHI----IEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFC 503 +HK + H I E Q F+ +QT+ L +++ R +Y S V Q PL C Sbjct: 271 IHKVVEPGEQEHSFAFNIMEIQPFRRAAAIQTMSLDAER--RKLYVSSQWEVSQVPLDLC 328 Query: 504 GKH-GTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDASVCPASSPKPLP 562 + G C C+++RDPYC W C++++ +E R ++Q S+ PA K P Sbjct: 329 EVYGGGCHGCLMSRDPYCGWD--QGRCISIYSSE---RSVLQ------SINPAEPHKECP 377 Query: 563 PP 564 P Sbjct: 378 NP 379 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.133 0.416 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 31,165,668 Number of Sequences: 37866 Number of extensions: 1532962 Number of successful extensions: 5822 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 44 Number of HSP's successfully gapped in prelim test: 95 Number of HSP's that attempted gapping in prelim test: 5335 Number of HSP's gapped (non-prelim): 352 length of query: 738 length of database: 18,247,518 effective HSP length: 110 effective length of query: 628 effective length of database: 14,082,258 effective search space: 8843658024 effective search space used: 8843658024 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.