Guide to the Human Genome
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Search of human proteins with 21361914

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361914 semaphorin B [Homo sapiens]
         (761 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361914 semaphorin B [Homo sapiens]                              1557   0.0  
gi|39777610 semaphorin 4B precursor [Homo sapiens]                    471   e-133
gi|39777608 semaphorin 4B precursor [Homo sapiens]                    471   e-133
gi|157388902 semaphorin 4C [Homo sapiens]                             401   e-111
gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]                   385   e-106
gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]                   376   e-104
gi|28872814 semaphorin 4G [Homo sapiens]                              341   2e-93
gi|19923279 semaphorin W [Homo sapiens]                               337   2e-92
gi|5174673 semaphorin 3A precursor [Homo sapiens]                     301   1e-81
gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]           298   1e-80
gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]          297   3e-80
gi|188497703 semaphorin 3F [Homo sapiens]                             291   2e-78
gi|41406086 semaphorin 3D [Homo sapiens]                              288   1e-77
gi|5454048 semaphorin 3C [Homo sapiens]                               282   7e-76
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]                    267   3e-71
gi|9910362 semaphorin sem2 [Homo sapiens]                             263   6e-70
gi|147904700 semaphorin 5A [Homo sapiens]                             253   6e-67
gi|6912650 semaphorin 3E [Homo sapiens]                               252   1e-66
gi|11991660 sema domain, transmembrane domain (TM), and cytoplas...   244   2e-64
gi|19718780 semaphorin 6B precursor [Homo sapiens]                    241   2e-63
gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]          234   3e-61
gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]          233   5e-61
gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]          233   5e-61
gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]          233   5e-61
gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]          229   7e-60
gi|16306552 semaphorin Y [Homo sapiens]                               218   2e-56
gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]          197   4e-50
gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]     166   7e-41
gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]       164   2e-40
gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]                   152   9e-37

>gi|21361914 semaphorin B [Homo sapiens]
          Length = 761

 Score = 1557 bits (4031), Expect = 0.0
 Identities = 761/761 (100%), Positives = 761/761 (100%)

Query: 1   MALPALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKG 60
           MALPALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKG
Sbjct: 1   MALPALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKG 60

Query: 61  LQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSN 120
           LQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSN
Sbjct: 61  LQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSN 120

Query: 121 ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP 180
           ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP
Sbjct: 121 ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP 180

Query: 181 AHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAAIPST 240
           AHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAAIPST
Sbjct: 181 AHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAAIPST 240

Query: 241 QVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQLP 300
           QVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQLP
Sbjct: 241 QVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQLP 300

Query: 301 FNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKE 360
           FNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKE
Sbjct: 301 FNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKE 360

Query: 361 TSRWTTYRGPETNPRPGSCSVGPSSDKALTFMKDHFLMDEQVVGTPLLVKSGVEYTRLAV 420
           TSRWTTYRGPETNPRPGSCSVGPSSDKALTFMKDHFLMDEQVVGTPLLVKSGVEYTRLAV
Sbjct: 361 TSRWTTYRGPETNPRPGSCSVGPSSDKALTFMKDHFLMDEQVVGTPLLVKSGVEYTRLAV 420

Query: 421 ETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGA 480
           ETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGA
Sbjct: 421 ETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGA 480

Query: 481 VFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMER 540
           VFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMER
Sbjct: 481 VFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMER 540

Query: 541 GNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVPE 600
           GNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVPE
Sbjct: 541 GNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVPE 600

Query: 601 ASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPVISYWVDSQDQTLALDPELAGIPREH 660
           ASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPVISYWVDSQDQTLALDPELAGIPREH
Sbjct: 601 ASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPVISYWVDSQDQTLALDPELAGIPREH 660

Query: 661 VKVPLTRVSGGAALAAQQSYWPHFVTVTVLFALVLSGALIILVASPLRALRARGKVQGCE 720
           VKVPLTRVSGGAALAAQQSYWPHFVTVTVLFALVLSGALIILVASPLRALRARGKVQGCE
Sbjct: 661 VKVPLTRVSGGAALAAQQSYWPHFVTVTVLFALVLSGALIILVASPLRALRARGKVQGCE 720

Query: 721 TLRPGEKAPLSREQHLQSPKECRTSASDVDADNNCLGTEVA 761
           TLRPGEKAPLSREQHLQSPKECRTSASDVDADNNCLGTEVA
Sbjct: 721 TLRPGEKAPLSREQHLQSPKECRTSASDVDADNNCLGTEVA 761


>gi|39777610 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  471 bits (1213), Expect = e-133
 Identities = 297/760 (39%), Positives = 422/760 (55%), Gaps = 59/760 (7%)

Query: 5   ALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDF 64
           AL   P  LL L L  LLQ   PT           PR+    G E R    F  + + ++
Sbjct: 18  ALPPRPPLLLLLLLLLLLQPPPPTWALS-------PRISLPLGSEERPFLRFEAEHISNY 70

Query: 65  DTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNM-IPWPASDRKKSECAFKKKSNETQ 123
             LLLS DG TLYVGAREA+ AL      +P  +   + W A   KK +C+FK K  +  
Sbjct: 71  TALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRD 130

Query: 124 CFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVM--EGKGQSPFDPA 181
           C N+I++L+  + +HL+TCGT AFSP CT+I +++  L    +  V+  +GKG+ PFDP 
Sbjct: 131 CQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPN 190

Query: 182 HKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAA--IPS 239
            K TA++VDG LY+GT+++F G++P + R+   +P  KT++ L WL  D +FVA+  IP 
Sbjct: 191 FKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTESSLNWLQ-DPAFVASAYIPE 248

Query: 240 T--------QVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQL 291
           +          +YFFF ET  EF+FFE    SR+AR+CK D GGE++LQ++WT+FLKAQL
Sbjct: 249 SLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQL 308

Query: 292 LCTQPGQ-LPFNVIRHAVLLPADSPTAPH-----IYAVFTSQWQVGGTRSSAVCAFSLLD 345
           LC++P    PFNV++    L   SP+         Y VFTSQW  G T  SAVC F++ D
Sbjct: 309 LCSRPDDGFPFNVLQDVFTL---SPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKD 365

Query: 346 IERVFKGKYKELNKETSRWTTYRGPETNPRPGSCSVGPS-----------SDKALTFMKD 394
           ++RVF G YKE+N+ET +W T   P   PRPG+C    +            D+ L F+KD
Sbjct: 366 VQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKD 425

Query: 395 HFLMDEQVVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSA 454
           HFLMD QV    LL++    Y R+AV    GL  H++ V++LGT  G LHKAV  G    
Sbjct: 426 HFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVSVG-PRV 483

Query: 455 HLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHC 514
           H++EE+Q+F   +PV+NL L   +G ++     GV +VP ANCS+Y SC DC+LARDP+C
Sbjct: 484 HIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYC 543

Query: 515 AWDPESRTCCLLSAPNL--NSWKQDMERGNPEWAC-ASGPMSRSLRPQSRPQIIKEVLAV 571
           AW   S     L  P L    W QD+E  + +  C AS  +S S  P    +  ++V   
Sbjct: 544 AWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGE-KPCEQVQFQ 602

Query: 572 PNSILELPCPHLSALASYYWSHGPAAVPEASS--TVYNGSLLLIVQDGVGGLYQCWATEN 629
           PN++  L CP LS LA+  W    A V  ++S   +  G LLL+    +G  +QCW+ E 
Sbjct: 603 PNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGE-FQCWSLEE 661

Query: 630 GFSYPVISYWVDSQDQTLALDPELAG-IPREHVKVPLTRVS----GGAALAAQQSYWPHF 684
           GF   V SY  +  +  +A   +  G +P   V +  +RVS    G A+  A +SYW  F
Sbjct: 662 GFQQLVASYCPEVVEDGVADQTDEGGSVP---VIISTSRVSAPAGGKASWGADRSYWKEF 718

Query: 685 VTVTVLFALVLSGALIILVASPLRALRARGKVQGCETLRP 724
           + +  LF L +   ++ L+     +++   K   C ++ P
Sbjct: 719 LVMCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHP 758


>gi|39777608 semaphorin 4B precursor [Homo sapiens]
          Length = 837

 Score =  471 bits (1213), Expect = e-133
 Identities = 297/760 (39%), Positives = 422/760 (55%), Gaps = 59/760 (7%)

Query: 5   ALGLDPWSLLGLFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDF 64
           AL   P  LL L L  LLQ   PT           PR+    G E R    F  + + ++
Sbjct: 18  ALPPRPPLLLLLLLLLLLQPPPPTWALS-------PRISLPLGSEERPFLRFEAEHISNY 70

Query: 65  DTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNM-IPWPASDRKKSECAFKKKSNETQ 123
             LLLS DG TLYVGAREA+ AL      +P  +   + W A   KK +C+FK K  +  
Sbjct: 71  TALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQCSFKGKDPQRD 130

Query: 124 CFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVM--EGKGQSPFDPA 181
           C N+I++L+  + +HL+TCGT AFSP CT+I +++  L    +  V+  +GKG+ PFDP 
Sbjct: 131 CQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLEDGKGRCPFDPN 190

Query: 182 HKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAA--IPS 239
            K TA++VDG LY+GT+++F G++P + R+   +P  KT++ L WL  D +FVA+  IP 
Sbjct: 191 FKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPT-KTESSLNWLQ-DPAFVASAYIPE 248

Query: 240 T--------QVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQL 291
           +          +YFFF ET  EF+FFE    SR+AR+CK D GGE++LQ++WT+FLKAQL
Sbjct: 249 SLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRWTSFLKAQL 308

Query: 292 LCTQPGQ-LPFNVIRHAVLLPADSPTAPH-----IYAVFTSQWQVGGTRSSAVCAFSLLD 345
           LC++P    PFNV++    L   SP+         Y VFTSQW  G T  SAVC F++ D
Sbjct: 309 LCSRPDDGFPFNVLQDVFTL---SPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCVFTMKD 365

Query: 346 IERVFKGKYKELNKETSRWTTYRGPETNPRPGSCSVGPS-----------SDKALTFMKD 394
           ++RVF G YKE+N+ET +W T   P   PRPG+C    +            D+ L F+KD
Sbjct: 366 VQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVLNFLKD 425

Query: 395 HFLMDEQVVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSA 454
           HFLMD QV    LL++    Y R+AV    GL  H++ V++LGT  G LHKAV  G    
Sbjct: 426 HFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLH-HTYDVLFLGTGDGRLHKAVSVG-PRV 483

Query: 455 HLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHC 514
           H++EE+Q+F   +PV+NL L   +G ++     GV +VP ANCS+Y SC DC+LARDP+C
Sbjct: 484 HIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARDPYC 543

Query: 515 AWDPESRTCCLLSAPNL--NSWKQDMERGNPEWAC-ASGPMSRSLRPQSRPQIIKEVLAV 571
           AW   S     L  P L    W QD+E  + +  C AS  +S S  P    +  ++V   
Sbjct: 544 AWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGE-KPCEQVQFQ 602

Query: 572 PNSILELPCPHLSALASYYWSHGPAAVPEASS--TVYNGSLLLIVQDGVGGLYQCWATEN 629
           PN++  L CP LS LA+  W    A V  ++S   +  G LLL+    +G  +QCW+ E 
Sbjct: 603 PNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGE-FQCWSLEE 661

Query: 630 GFSYPVISYWVDSQDQTLALDPELAG-IPREHVKVPLTRVS----GGAALAAQQSYWPHF 684
           GF   V SY  +  +  +A   +  G +P   V +  +RVS    G A+  A +SYW  F
Sbjct: 662 GFQQLVASYCPEVVEDGVADQTDEGGSVP---VIISTSRVSAPAGGKASWGADRSYWKEF 718

Query: 685 VTVTVLFALVLSGALIILVASPLRALRARGKVQGCETLRP 724
           + +  LF L +   ++ L+     +++   K   C ++ P
Sbjct: 719 LVMCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHP 758


>gi|157388902 semaphorin 4C [Homo sapiens]
          Length = 833

 Score =  401 bits (1030), Expect = e-111
 Identities = 246/633 (38%), Positives = 343/633 (54%), Gaps = 48/633 (7%)

Query: 39  MPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLK 98
           +PR    +G+    +  F Q G+QDF TL L+     LYVGAREA+ A  ++      L+
Sbjct: 28  VPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGAREALFAFSME---ALELQ 84

Query: 99  NMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQD 158
             I W A   KK+EC  K K+N+T+CFNFIR L  YN +HLY CGT+AF P CT++ +  
Sbjct: 85  GAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQPKCTYVNM-- 142

Query: 159 SYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVL 218
                +   +  +GKG+ P+DPA  H  +LVDG LYS T+NNFLG+EPI++R +G    +
Sbjct: 143 -LTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGPHHSM 201

Query: 219 KTDNFLRWLHHDASFV--AAIPST--------QVVYFFFEETASEFDFFERLHTSRVARV 268
           KT+    WL ++  FV  A +P +          VYFFF E A E D +     +RVARV
Sbjct: 202 KTEYLAFWL-NEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARV 260

Query: 269 CKNDVGGEKLLQKKWTTFLKAQLLCTQPG-QLPFNVIRHAVLLPADSPTAPHIYAVFTSQ 327
           CK D+GG + LQ+KWTTFLKA+L C+ P  QL FN ++    L   S      + VF +Q
Sbjct: 261 CKGDMGGARTLQRKWTTFLKARLACSAPNWQLYFNQLQAMHTLQDTSWHNTTFFGVFQAQ 320

Query: 328 WQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSC-------- 379
           W  G    SA+C + L +I+RVF+G YKE ++E  +W  Y  P  +PRPGSC        
Sbjct: 321 W--GDMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTDPVPSPRPGSCINNWHRRH 378

Query: 380 ---SVGPSSDKALTFMKDHFLMDEQV---VGTPLLVKSGVEYTRLAVETAQGLDGHSHLV 433
              S     D  L F+K H LM+EQV      PLLVK G  +T L  +   GLDG ++ V
Sbjct: 379 GYTSSLELPDNILNFVKKHPLMEEQVGPRWSRPLLVKKGTNFTHLVADRVTGLDGATYTV 438

Query: 434 MYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVP 493
           +++GT  G L KAV  G    HL+EE+QLF D EP+R+L L+ ++  +F G    + ++P
Sbjct: 439 LFIGTGDGWLLKAVSLG-PWVHLIEELQLF-DQEPMRSLVLSQSKKLLFAGSRSQLVQLP 496

Query: 494 RANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMS 553
            A+C  Y SC DCVLARDP+CAW   +  C  +   + +   Q +   +    C +   S
Sbjct: 497 VADCMKYRSCADCVLARDPYCAWSVNTSRCVAVGGHSGSLLIQHVMTSDTSGIC-NLRGS 555

Query: 554 RSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVP--EASSTVYNGSLL 611
           + +RP       K +  V  + L LPC   S LA   W+ G   +P  +  S +Y+  L 
Sbjct: 556 KKVRPTP-----KNITVVAGTDLVLPCHLSSNLAHARWTFGGRDLPAEQPGSFLYDARLQ 610

Query: 612 LIV----QDGVGGLYQCWATENGFSYPVISYWV 640
            +V    Q    G Y C++ E G       Y V
Sbjct: 611 ALVVMAAQPRHAGAYHCFSEEQGARLAAEGYLV 643


>gi|214010218 semaphorin 4D isoform 1 [Homo sapiens]
          Length = 862

 Score =  385 bits (988), Expect = e-106
 Identities = 243/629 (38%), Positives = 340/629 (54%), Gaps = 64/629 (10%)

Query: 38  PMPRVRYYAGDERRALSF--FHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVP 95
           P+PR+ +    E R +    FH+  + ++  LLLS D +TLY+GAREA+ A++  +  + 
Sbjct: 26  PIPRITW----EHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALN--IS 79

Query: 96  RLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIE 155
             ++ + W  S+ KK++CA K KS +T+C N+IRVL   + T LY CGT AF PAC  + 
Sbjct: 80  EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLN 139

Query: 156 LQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQ 215
           L     L  +ED    GKG+ PFDPAH +T+V+VDG LYSGT  NFLGSEPI+ R     
Sbjct: 140 LTSFKFLGKNED----GKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHS 195

Query: 216 PVLKTDNFLRWLHHDASFVAA-----IPST-----QVVYFFFEETASEFDFFERLHTSRV 265
           P L+T+  + WL+ + SFV A      P +       VYFFF E + E++F  R+   R+
Sbjct: 196 P-LRTEYAIPWLN-EPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRI 253

Query: 266 ARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQ-LPFNVIRHAVLLPADSPTAPHIYAVF 324
           ARVCK D GG + LQKKWT+FLKA+L+C++P   L FNV+R   +L +     P  YA+F
Sbjct: 254 ARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALF 313

Query: 325 TSQWQVGGTRSSAVCAFSLLDIERVFK-GKYKE---LNKETSRWTTYRGPETNPRPGSCS 380
           T   Q+     SAVCA++L   E VF  GKY +   + +  ++W  Y GP   PRPG+C 
Sbjct: 314 TP--QLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACI 371

Query: 381 VGPS-----------SDKALTFMKDHFLMDEQVV---GTPLLVKSGVEYTRLAVETAQGL 426
              +            DK L F+KDH LMD+ V      P L+K  V YT++ V+  Q L
Sbjct: 372 DSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQAL 431

Query: 427 DGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQG--AVFVG 484
           DG  + VM++ T  G+LHKA +S + + H++EE QLF D EPV+ L L+  +G   V+ G
Sbjct: 432 DGTVYDVMFVSTDRGALHKA-ISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAG 490

Query: 485 FSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPE 544
            + GV + P A C  + +C DCVLARDP+CAW P + TC  L      S     E     
Sbjct: 491 SNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQEMSGDA 550

Query: 545 WACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWSHGPAAVPEASST 604
             C          P       ++         EL C   S LA  +W      V +A S 
Sbjct: 551 SVC----------PDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKF-QNGVLKAESP 599

Query: 605 VY-----NGSLLLIVQDGVGGLYQCWATE 628
            Y        L+  + +G  G+YQC + E
Sbjct: 600 KYGLMGRKNLLIFNLSEGDSGVYQCLSEE 628


>gi|214010220 semaphorin 4D isoform 2 [Homo sapiens]
          Length = 738

 Score =  376 bits (965), Expect = e-104
 Identities = 221/522 (42%), Positives = 309/522 (59%), Gaps = 48/522 (9%)

Query: 38  PMPRVRYYAGDERRALSF--FHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVP 95
           P+PR+ +    E R +    FH+  + ++  LLLS D +TLY+GAREA+ A++  +  + 
Sbjct: 26  PIPRITW----EHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALN--IS 79

Query: 96  RLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIE 155
             ++ + W  S+ KK++CA K KS +T+C N+IRVL   + T LY CGT AF PAC  + 
Sbjct: 80  EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLN 139

Query: 156 LQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQ 215
           L     L  +ED    GKG+ PFDPAH +T+V+VDG LYSGT  NFLGSEPI+ R     
Sbjct: 140 LTSFKFLGKNED----GKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHS 195

Query: 216 PVLKTDNFLRWLHHDASFVAA-----IPST-----QVVYFFFEETASEFDFFERLHTSRV 265
           P L+T+  + WL+ + SFV A      P +       VYFFF E + E++F  R+   R+
Sbjct: 196 P-LRTEYAIPWLN-EPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRI 253

Query: 266 ARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPGQ-LPFNVIRHAVLLPADSPTAPHIYAVF 324
           ARVCK D GG + LQKKWT+FLKA+L+C++P   L FNV+R   +L +     P  YA+F
Sbjct: 254 ARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALF 313

Query: 325 TSQWQVGGTRSSAVCAFSLLDIERVFK-GKYKE---LNKETSRWTTYRGPETNPRPGSCS 380
           T   Q+     SAVCA++L   E VF  GKY +   + +  ++W  Y GP   PRPG+C 
Sbjct: 314 TP--QLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNGPVPKPRPGACI 371

Query: 381 VGPS-----------SDKALTFMKDHFLMDEQVV---GTPLLVKSGVEYTRLAVETAQGL 426
              +            DK L F+KDH LMD+ V      P L+K  V YT++ V+  Q L
Sbjct: 372 DSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQAL 431

Query: 427 DGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQG--AVFVG 484
           DG  + VM++ T  G+LHKA +S + + H++EE QLF D EPV+ L L+  +G   V+ G
Sbjct: 432 DGTVYDVMFVSTDRGALHKA-ISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAG 490

Query: 485 FSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLL 526
            + GV + P A C  + +C DCVLARDP+CAW P + TC  L
Sbjct: 491 SNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVAL 532


>gi|28872814 semaphorin 4G [Homo sapiens]
          Length = 843

 Score =  341 bits (874), Expect = 2e-93
 Identities = 247/692 (35%), Positives = 344/692 (49%), Gaps = 80/692 (11%)

Query: 57  HQKG-LQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAF 115
           H KG  Q++ TLLL      L VGAR A+ +L   D G    K  I W AS   +S+C  
Sbjct: 48  HFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDIGDGAHKE-IHWEASPEMQSKCHQ 106

Query: 116 KKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQ 175
           K K+N+T+CFN +R L   N THLY CGT AF P C  I+ + ++ LP S +   EGK +
Sbjct: 107 KGKNNQTECFNHVRFLQRLNSTHLYACGTHAFQPLCAAIDAE-AFTLPTSFE---EGKEK 162

Query: 176 SPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFV- 234
            P+DPA   T +++DG LY+ T   F  S P + R+     +   +  + WL+ DA FV 
Sbjct: 163 CPYDPARGFTGLIIDGGLYTATRYEFR-SIPDIRRSRHPHSLRTEETPMHWLN-DAEFVF 220

Query: 235 ---------AAIPSTQVVYFFFEETASE-----FDFFERLH-TSRVARVCKNDVGGEKLL 279
                    +A+     VY+FF E A+E     F      H  +RVARVCK D+GG+K+L
Sbjct: 221 SVLVRESKASAVGDDDKVYYFFTERATEEGSGSFTQSRSSHRVARVARVCKGDLGGKKIL 280

Query: 280 QKKWTTFLKAQLLCTQPGQLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVC 339
           QKKWT+FLKA+L+C  P    +  +R    L A++ +  H YA FT   Q     +SA+C
Sbjct: 281 QKKWTSFLKARLICHIP---LYETLRGVCSLDAETSSRTHFYAAFTLSTQWKTLEASAIC 337

Query: 340 AFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSC------SVGPSSDK-----A 388
            + L +I+ VF G Y E    + RW  Y G    PRPGSC      S G +S +      
Sbjct: 338 RYDLAEIQAVFAGPYMEYQDGSRRWGRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLV 397

Query: 389 LTFMKDHFLMDEQVV---GTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHK 445
           L F+K H LM   VV   G PLL+K  + YT L         G ++ +++LGT  G +HK
Sbjct: 398 LDFVKLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTPAGPTYDLLFLGTADGWIHK 457

Query: 446 AVVSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVD 505
           AVV G S  H++EE Q+F + + V NL ++  Q +++VG   GV ++P ++CS Y SC D
Sbjct: 458 AVVLG-SGMHIIEETQVFRESQSVENLVISLLQHSLYVGAPSGVIQLPLSSCSRYRSCYD 516

Query: 506 CVLARDPHCAWDPESRTCCLL------SAPNLNSWKQDMERGNPEWACASGPMSRSLRPQ 559
           C+LARDP+C WDP +  C         S  +  +  QD+ERGN    C S   SR   P 
Sbjct: 517 CILARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDIERGNR--GCES---SRDTGP- 570

Query: 560 SRPQIIKEVLAVPNSILELPCPHLSALASYYW----SHGPAAVPEASSTVYNGSLLLIVQ 615
             P  +K    +    + LPC   S LA   W    S G +          +G L+   Q
Sbjct: 571 --PPPLKTRSVLRGDDVLLPCDQPSNLARALWLLNGSMGLSDGQGGYRVGVDGLLVTDAQ 628

Query: 616 DGVGGLYQCWATENGFSYPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALA 675
               G Y C+A ENG    + SY +  +  T A  P+    P             GA LA
Sbjct: 629 PEHSGNYGCYAEENGLRTLLASYSLTVRPATPAPAPKAPATP-------------GAQLA 675

Query: 676 AQQSYWPHFVTVTVLFALVLSGALIILVASPL 707
                    V +  + A+   G L +++AS L
Sbjct: 676 PD-------VRLLYVLAIAALGGLCLILASSL 700


>gi|19923279 semaphorin W [Homo sapiens]
          Length = 770

 Score =  337 bits (865), Expect = 2e-92
 Identities = 230/658 (34%), Positives = 328/658 (49%), Gaps = 58/658 (8%)

Query: 19  FQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYV 78
           F LL L + +    G     +PR      +    L+ F      ++  LL+    +TLYV
Sbjct: 20  FPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYV 79

Query: 79  GAREAILALDIQDPGV-PRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVT 137
           GAR+ I AL +   G  PR    I W   +  +  C  KK   E +C NF+++L   N +
Sbjct: 80  GARDTIFALSLPFSGERPR---RIDWMVPEAHRQNCR-KKGKKEDECHNFVQILAIANAS 135

Query: 138 HLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGT 197
           HL TCGTFAF P C  I++     +    +++  G+G+ PF+PA +  AV+  G+LY+ T
Sbjct: 136 HLLTCGTFAFDPKCGVIDVSRFQQV----ERLESGRGKCPFEPAQRSAAVMAGGVLYAAT 191

Query: 198 MNNFLGSEPILMRTLG-SQPVLKTDNFLRWLHHDASFVAAIPSTQV----------VYFF 246
           + N+LG+EPI+ R +G ++  ++TD    WL+  A FVAA+  +            +YFF
Sbjct: 192 VKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPA-FVAAVALSPAEWGDEDGDDEIYFF 250

Query: 247 FEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQP--GQLPFNVI 304
           F ET+  FD +ER+   RVARVC  D+GG K LQ++WTTFLKA LLC  P  G+    + 
Sbjct: 251 FTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQ 310

Query: 305 RHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRW 364
             AVL P      P  Y +F+SQW+  G   SAVCAF   DI  V  G ++EL  + +R 
Sbjct: 311 DVAVLRPELGAGTPIFYGIFSSQWE--GATISAVCAFRPQDIRTVLNGPFRELKHDCNRG 368

Query: 365 TTYRGPET-NPRPGSC--------SVGPS---SDKALTFMKDHFLMDEQVV---GTPLLV 409
                 +   PRPG C          G S    D+ LTF++DH LMD  V    G PLLV
Sbjct: 369 LPVVDNDVPQPRPGECITNNMKLRHFGSSLSLPDRVLTFIRDHPLMDRPVFPADGHPLLV 428

Query: 410 KSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHLVEEIQLFPDPEPV 469
            +   Y R+       L G  + V+YLGT  G LH+AV  G +   ++E++ LFP+P+PV
Sbjct: 429 TTDTAYLRVVAHRVTSLSGKEYDVLYLGTEDGHLHRAVRIG-AQLSVLEDLALFPEPQPV 487

Query: 470 RNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESRTCCLLSAP 529
            N++L      + VG    V +V   NC   +SC +C+LA+DP CAW       C+  A 
Sbjct: 488 ENMKL--YHSWLLVGSRTEVTQVNTTNCGRLQSCSECILAQDPVCAWSFRLDE-CVAHAG 544

Query: 530 NLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASY 589
                 QD+E  +    C   P  R         ++ EV     + + LPC   SA AS 
Sbjct: 545 EHRGLVQDIESADVSSLCPKEPGER--------PVVFEVPVATAAHVVLPCSPSSAWASC 596

Query: 590 YWSHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPVISY---WVDSQD 644
            W H P+ V   + T     L ++V  G  G Y C   E G ++ V +Y   W   +D
Sbjct: 597 VW-HQPSGV--TALTPRRDGLEVVVTPGAMGAYACECQEGGAAHVVAAYSLVWGSQRD 651


>gi|5174673 semaphorin 3A precursor [Homo sapiens]
          Length = 771

 Score =  301 bits (771), Expect = 1e-81
 Identities = 199/629 (31%), Positives = 310/629 (49%), Gaps = 58/629 (9%)

Query: 48  DERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNM--IPWPA 105
           +    ++F        + T LL  + + LYVGA++ I + D+ +     +K+   I WP 
Sbjct: 41  ESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFDLVN-----IKDFQKIVWPV 95

Query: 106 SDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIEL---QDSYLL 162
           S  ++ EC +  K    +C NFI+VL +YN THLY CGT AF P CT+IE+    +  + 
Sbjct: 96  SYTRRDECKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEIGHHPEDNIF 155

Query: 163 PISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDN 222
            +       G+G+SP+DP     ++L+DG LYSGT  +F+G +  + RTLG    ++T+ 
Sbjct: 156 KLENSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQ 215

Query: 223 F-LRWLHHDASFVAA-------IPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVG 274
              RWL +D  F++A        P    VYFFF E A + +   +   +R+ ++CKND G
Sbjct: 216 HDSRWL-NDPKFISAHLISESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFG 274

Query: 275 GEKLLQKKWTTFLKAQLLCTQPG----QLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQV 330
           G + L  KWTTFLKA+L+C+ PG       F+ ++   L+    P  P +Y VFT+   +
Sbjct: 275 GHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNFKDPKNPVVYGVFTTSSNI 334

Query: 331 GGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSC---------SV 381
              + SAVC +S+ D+ RVF G Y   +    +W  Y+G    PRPG+C         S 
Sbjct: 335 --FKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDST 392

Query: 382 GPSSDKALTFMKDHFLMDEQVV---GTPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYL 436
               D  +TF + H  M   V      P+++K+ V Y  T++ V+     DG  + VM++
Sbjct: 393 KDLPDDVITFARSHPAMYNPVFPMNNRPIVIKTDVNYQFTQIVVDRVDAEDG-QYDVMFI 451

Query: 437 GTTTGSLHKAV-----VSGDSSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWR 491
           GT  G++ K V        D    L+EE+ +F +P  +  ++L+  Q  +++G + GV +
Sbjct: 452 GTDVGTVLKVVSIPKETWYDLEEVLLEEMTVFREPTAISAMELSTKQQQLYIGSTAGVAQ 511

Query: 492 VPRANCSVY-ESCVDCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASG 550
           +P   C +Y ++C +C LARDP+CAWD  + +    +A    + +QD+  G+P   C+  
Sbjct: 512 LPLHRCDIYGKACAECCLARDPYCAWDGSACSRYFPTAKR-RTRRQDIRNGDPLTHCSDL 570

Query: 551 PMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYWS--------HGPAAVPEAS 602
                       +II     V NS   L C   S  A  YW              V +  
Sbjct: 571 HHDNHHGHSPEERII---YGVENSSTFLECSPKSQRALVYWQFQRRNEERKEEIRVDDHI 627

Query: 603 STVYNGSLLLIVQDGVGGLYQCWATENGF 631
                G LL  +Q    G Y C A E+GF
Sbjct: 628 IRTDQGLLLRSLQQKDSGNYLCHAVEHGF 656


>gi|4759092 semaphorin 3B isoform 1 precursor [Homo sapiens]
          Length = 749

 Score =  298 bits (763), Expect = 1e-80
 Identities = 201/651 (30%), Positives = 319/651 (49%), Gaps = 62/651 (9%)

Query: 32  GGGGQGPMP---RVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALD 88
           G G   P P   R+ +        L  F  +    +  LL+  +   L+VGA   + +L+
Sbjct: 20  GLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLN 79

Query: 89  IQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFS 148
           + +  + +    + WPA    + EC +  K   T+C NF+++L +YN THL  CGT AF 
Sbjct: 80  LDN--ISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFH 137

Query: 149 PACTFIEL---QDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSE 205
           P C F+E+    +  +L +   ++ +GKG+SP+DP H+  +VLV   LYSG   + +G +
Sbjct: 138 PTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRD 197

Query: 206 PILMRTLGSQPVLKTD-NFLRWLHHDASFVAAI-------PSTQVVYFFFEETASEF-DF 256
             + R+LG +P L+T+ +  RWL+ +  FV          P    +YFFF ETA E    
Sbjct: 198 FTIFRSLGQRPSLRTEPHDSRWLN-EPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPA 256

Query: 257 FERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQP---GQLPFNVIRHAVLLPAD 313
             RL  SRV ++C+NDVGG++ L  KWTTFLKA+L+C+ P   G   F+ ++   LL + 
Sbjct: 257 LGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSR 316

Query: 314 SPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETN 373
               P +YAVF++   +   + SAVC +S+ D+ R F G +        +W +Y+G    
Sbjct: 317 DHRTPLLYAVFSTSSSI--FQGSAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPY 374

Query: 374 PRPGSC---------SVGPSSDKALTFMKDHFLMDEQVV---GTPLLVKSGVEY--TRLA 419
           PRPG C         S     D  + F ++H LM   V+   G PL ++ G  Y  T++A
Sbjct: 375 PRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIA 434

Query: 420 VETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSS-----AHLVEEIQLFPDPEPVRNLQL 474
            +     DGH + V+++GT  G++ K +     S       L+EE+ +F D   V ++Q+
Sbjct: 435 ADRVAAADGH-YDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDSAAVTSMQI 493

Query: 475 APTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCAWDPESRTCCLLSAPNLNS 533
           +  +  ++V     V ++    C+ +   C +C LARDP+CAWD  + T    SA     
Sbjct: 494 SSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQPSAKR-RF 552

Query: 534 WKQDMERGNPEWACASGPMSRSLRPQSRPQIIK-EVLAVPNSILELPCPHLSALASYYW- 591
            +QD+  G+P   C+           SRP +++ +V  V  S   L C   S  A   W 
Sbjct: 553 RRQDVRNGDPSTLCSG--------DSSRPALLEHKVFGVEGSSAFLECEPRSLQARVEWT 604

Query: 592 -------SHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPV 635
                  +H      E +     G LL  ++    G+Y C A E GF+ P+
Sbjct: 605 FQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPL 655


>gi|54607089 semaphorin 3B isoform 2 precursor [Homo sapiens]
          Length = 748

 Score =  297 bits (760), Expect = 3e-80
 Identities = 202/651 (31%), Positives = 318/651 (48%), Gaps = 63/651 (9%)

Query: 32  GGGGQGPMP---RVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALD 88
           G G   P P   R+ +        L  F  +    +  LL+  +   L+VGA   + +L+
Sbjct: 20  GLGSAAPSPPRLRLSFQELQAWHGLQTFSLERTCCYQALLVDEERGRLFVGAENHVASLN 79

Query: 89  IQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFS 148
           + +  + +    + WPA    + EC +  K   T+C NF+++L +YN THL  CGT AF 
Sbjct: 80  LDN--ISKRAKKLAWPAPVEWREECNWAGKDIGTECMNFVKLLHAYNRTHLLACGTGAFH 137

Query: 149 PACTFIEL---QDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSE 205
           P C F+E+    +  +L +   ++ +GKG+SP+DP H+  +VLV   LYSG   + +G +
Sbjct: 138 PTCAFVEVGHRAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGEELYSGVAADLMGRD 197

Query: 206 PILMRTLGSQPVLKTD-NFLRWLHHDASFVAAI-------PSTQVVYFFFEETASEF-DF 256
             + R+LG +P L+T+ +  RWL+ +  FV          P    +YFFF ETA E    
Sbjct: 198 FTIFRSLGQRPSLRTEPHDSRWLN-EPKFVKVFWIPESENPDDDKIYFFFRETAVEAAPA 256

Query: 257 FERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQP---GQLPFNVIRHAVLLPAD 313
             RL  SRV ++C+NDVGG++ L  KWTTFLKA+L+C+ P   G   F+ ++   LL + 
Sbjct: 257 LGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSR 316

Query: 314 SPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETN 373
               P +YAVF++     G   SAVC +S+ D+ R F G +        +W +Y+G    
Sbjct: 317 DHRTPLLYAVFSTSSIFQG---SAVCVYSMNDVRRAFLGPFAHKEGPMHQWVSYQGRVPY 373

Query: 374 PRPGSC---------SVGPSSDKALTFMKDHFLMDEQVV---GTPLLVKSGVEY--TRLA 419
           PRPG C         S     D  + F ++H LM   V+   G PL ++ G  Y  T++A
Sbjct: 374 PRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVGANYTFTQIA 433

Query: 420 VETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSS-----AHLVEEIQLFPDPEPVRNLQL 474
            +     DGH + V+++GT  G++ K +     S       L+EE+ +F D   V ++Q+
Sbjct: 434 ADRVAAADGH-YDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFEDSAAVTSMQI 492

Query: 475 APTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCAWDPESRTCCLLSAPNLNS 533
           +  +  ++V     V ++    C+ +   C +C LARDP+CAWD  + T    SA     
Sbjct: 493 SSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVACTRFQPSAKR-RF 551

Query: 534 WKQDMERGNPEWACASGPMSRSLRPQSRPQIIK-EVLAVPNSILELPCPHLSALASYYW- 591
            +QD+  G+P   C+           SRP +++ +V  V  S   L C   S  A   W 
Sbjct: 552 RRQDVRNGDPSTLCSG--------DSSRPALLEHKVFGVEGSSAFLECEPRSLQARVEWT 603

Query: 592 -------SHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPV 635
                  +H      E +     G LL  ++    G+Y C A E GF+ P+
Sbjct: 604 FQRAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLCAAVEQGFTQPL 654


>gi|188497703 semaphorin 3F [Homo sapiens]
          Length = 785

 Score =  291 bits (744), Expect = 2e-78
 Identities = 201/649 (30%), Positives = 311/649 (47%), Gaps = 91/649 (14%)

Query: 63  DFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNET 122
           D+  LL   D + +YVG+++ +L+LD+ D  + R   +I W AS ++  EC    K    
Sbjct: 56  DYRILLKDEDHDRMYVGSKDYVLSLDLHD--INREPLIIHWAASPQRIEECVLSGKDVNG 113

Query: 123 QCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIEL-------------------------- 156
           +C NF+R++  +N THLY CGT A++P CT++                            
Sbjct: 114 ECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQATPWTQTQAVRGRGSRATDGA 173

Query: 157 --------QDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPIL 208
                   +  Y+  +  +++  GKG+ P+DP     + L++  LY+G   +F+G++  +
Sbjct: 174 LRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAI 233

Query: 209 MRTLGSQPVLKTDNF-LRWLHHDASFVAA--IPST-----QVVYFFFEETASEFDFFERL 260
            RTLG Q  ++TD +  RWL +D SF+ A  IP +       +YFFF E ++E      +
Sbjct: 234 FRTLGKQTAMRTDQYNSRWL-NDPSFIHAELIPDSAERNDDKLYFFFRERSAEAPQSPAV 292

Query: 261 HTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPG----QLPFNVIRHAVLLPADSPT 316
           + +R+ R+C ND GG   L  KW+TFLKA+L+C+ PG    +  F+ ++   +       
Sbjct: 293 Y-ARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDVR 351

Query: 317 APHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRP 376
            P IYAVFTS   V   R SAVC +S+ DI  VF G +        +W  + G    PRP
Sbjct: 352 NPVIYAVFTSSGSV--FRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRP 409

Query: 377 GSCSVG---PS-------SDKALTFMKDHFLMDEQVV---GTPLLVKSGVEY--TRLAVE 421
           G+C  G   PS        D+ + FM+ H LM + V      PL+V++G  Y  T +AV+
Sbjct: 410 GTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVD 469

Query: 422 TAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHL----VEEIQLFPDPEPVRNLQLAPT 477
                DG  + V++LGT  G++ K +V       L    +EE+++F DP PV+ + ++  
Sbjct: 470 QVDAADGR-YEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSK 528

Query: 478 QGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCAWDPESRTCCLLSAPN-LNSWK 535
           +  ++V  + GV  +    C  Y  +C DC LARDP+CAWD   + C   +A +   S +
Sbjct: 529 RQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWD--GQACSRYTASSKRRSRR 586

Query: 536 QDMERGNPEWACASGPMSRSLRPQSRPQIIKEV-LAVPNSILELPCPHLSALASYYW--- 591
           QD+  GNP   C      R     +    ++ V   V  S   L C   S  A+  W   
Sbjct: 587 QDVRHGNPIRQC------RGFNSNANKNAVESVQYGVAGSAAFLECQPRSPQATVKWLFQ 640

Query: 592 -----SHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPV 635
                        +       G LL  +Q    GLY C ATEN F + V
Sbjct: 641 RDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVV 689


>gi|41406086 semaphorin 3D [Homo sapiens]
          Length = 777

 Score =  288 bits (737), Expect = 1e-77
 Identities = 207/672 (30%), Positives = 320/672 (47%), Gaps = 67/672 (9%)

Query: 16  LFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGD---ERRALSFFHQKGLQDFDTLLLSGD 72
           L +  +  L LP T   G  +  +PR++    D       + F       DF TLLL  +
Sbjct: 22  LMMLSMTMLFLPVT---GTLKQNIPRLKLTYKDLLLSNSCIPFLGSSEGLDFQTLLLDEE 78

Query: 73  GNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLV 132
              L +GA++ I  L + D  + +    I WPA+  +   C    K   T+C NFIRVL 
Sbjct: 79  RGRLLLGAKDHIFLLSLVD--LNKNFKKIYWPAAKERVELCKLAGKDANTECANFIRVLQ 136

Query: 133 SYNVTHLYTCGTFAFSPACTFIEL---QDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLV 189
            YN TH+Y CGT AF P C +I+L   ++  +  +    +  G+ + PFDP     +V+ 
Sbjct: 137 PYNKTHIYVCGTGAFHPICGYIDLGVYKEDIIFKLDTHNLESGRLKCPFDPQQPFASVMT 196

Query: 190 DGMLYSGTMNNFLGSEPILMRTLG---SQPVLKTDNFLRWLHHDASFVAAI-------PS 239
           D  LYSGT ++FLG +    R+LG       ++TD    +  + A F+          P 
Sbjct: 197 DEYLYSGTASDFLGKDTAFTRSLGPTHDHHYIRTDISEHYWLNGAKFIGTFFIPDTYNPD 256

Query: 240 TQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPG-- 297
              +YFFF E++ E    ++   SRV RVCKNDVGG++ L  KWTTFLKA+L+C+ PG  
Sbjct: 257 DDKIYFFFRESSQEGSTSDKTILSRVGRVCKNDVGGQRSLINKWTTFLKARLICSIPGSD 316

Query: 298 --QLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYK 355
                F+ ++   LLP      P +Y VFT+   +   + SAVC +S+ DI  VF G Y 
Sbjct: 317 GADTYFDELQDIYLLPTRDERNPVVYGVFTTTSSI--FKGSAVCVYSMADIRAVFNGPYA 374

Query: 356 ELNKETSRWTTYRGPETNPRPGSC----------SVGPSSDKALTFMKDHFLMDEQ---V 402
                  RW  Y G    PRPG+C          S     D  ++F+K H +M +    V
Sbjct: 375 HKESADHRWVQYDGRIPYPRPGTCPSKTYDPLIKSTRDFPDDVISFIKRHSVMYKSVYPV 434

Query: 403 VGTPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHL---- 456
            G P   +  V+Y  T++ V+     DG  + VM+LGT  G++ K V       ++    
Sbjct: 435 AGGPTFKRINVDYRLTQIVVDHVIAEDG-QYDVMFLGTDIGTVLKVVSISKEKWNMEEVV 493

Query: 457 VEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCA 515
           +EE+Q+F     + N++L+  Q  +++G   G+ ++    C  Y ++C DC LARDP+CA
Sbjct: 494 LEELQIFKHSSIILNMELSLKQQQLYIGSRDGLVQLSLHRCDTYGKACADCCLARDPYCA 553

Query: 516 WDPESRTCCLLSAP--NLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPN 573
           WD  +   C   AP     + +QD++ G+P   C    +  S+  ++  +  K +  +  
Sbjct: 554 WDGNA---CSRYAPTSKRRARRQDVKYGDPITQC--WDIEDSISHETADE--KVIFGIEF 606

Query: 574 SILELPCPHLSALASYYW-------SHGPAAVPEAS--STVYNGSLLLIVQDGVGGLYQC 624
           +   L C   S  A+  W        H     P+     T Y G L+  +Q    G+Y C
Sbjct: 607 NSTFLECIPKSQQATIKWYIQRSGDEHREELKPDERIIKTEY-GLLIRSLQKKDSGMYYC 665

Query: 625 WATENGFSYPVI 636
            A E+ F + ++
Sbjct: 666 KAQEHTFIHTIV 677


>gi|5454048 semaphorin 3C [Homo sapiens]
          Length = 751

 Score =  282 bits (722), Expect = 7e-76
 Identities = 201/648 (31%), Positives = 316/648 (48%), Gaps = 60/648 (9%)

Query: 34  GGQGPMPRVRYYAGDERRALSFFHQKGLQ----DFDTLLLSGDGNTLYVGAREAILALDI 89
           G   P  RV Y   DE R         L     D+  LL+  D + +YVG+++ IL+L+I
Sbjct: 21  GSSQPQARV-YLTFDELRETKTSEYFSLSHHPLDYRILLMDEDQDRIYVGSKDHILSLNI 79

Query: 90  QDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSP 149
            +     L   + WPAS  K  EC    K     C NF+RV+ ++N THLY CG+ AFSP
Sbjct: 80  NNISQEALS--VFWPASTIKVEECKMAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSP 137

Query: 150 ACTFIE--LQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPI 207
            CT++    +    + + + K   GKG+  F+P     +V+++  L+SG   +F+G++  
Sbjct: 138 VCTYLNRGRRSEDQVFMIDSKCESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAA 197

Query: 208 LMRTLGSQPVLKTDNF-LRWLHH----DASFV--AAIPSTQVVYFFFEETASEFDFFERL 260
           + R+L  +  ++TD    +WL      DA  +     P+   VYFFF+E  ++ +   + 
Sbjct: 198 IFRSLTKRNAVRTDQHNSKWLSEPMFVDAHVIPDGTDPNDAKVYFFFKEKLTDNNRSTKQ 257

Query: 261 HTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCT----QPGQLPFNVIRHAVLLPADSPT 316
             S +AR+C ND GG + L  KWTTFLKA+L+C+       +  F+ +    LL  D+P 
Sbjct: 258 IHSMIARICPNDTGGLRSLVNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPR 317

Query: 317 APHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRP 376
              +Y +FT+   V   + SAVC + L DI+ VF G +        +  +Y+G    PRP
Sbjct: 318 TTLVYGIFTTSSSV--FKGSAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRP 375

Query: 377 GSCSVGPSS----------DKALTFMKDHFLMDEQVV---GTPLLVKSGVE--YTRLAVE 421
           G+C  G  +          D  +TF+++H LM   +      PL+V+ G +  YT++AV+
Sbjct: 376 GTCPGGAFTPNMRTTKEFPDDVVTFIRNHPLMYNSIYPIHKRPLIVRIGTDYKYTKIAVD 435

Query: 422 TAQGLDGHSHLVMYLGTTTGSLHKAVV----SGDSSAHLVEEIQLFPDPEPVRNLQLAPT 477
                DG  H V++LGT  G++ K VV    +  S   ++EE+++F +  P+  ++++  
Sbjct: 436 RVNAADGRYH-VLFLGTDRGTVQKVVVLPTNNSVSGELILEELEVFKNHAPITTMKISSK 494

Query: 478 QGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCAWDPESRTCCLLSAP--NLNSW 534
           +  ++V  + GV +V    C +Y  +C DC LARDP+CAWD  S   C    P     S 
Sbjct: 495 KQQLYVSSNEGVSQVSLHRCHIYGTACADCCLARDPYCAWDGHS---CSRFYPTGKRRSR 551

Query: 535 KQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCPHLSALASYYW--- 591
           +QD+  GNP   C    +      ++  +I++    V N+   L C   S  AS  W   
Sbjct: 552 RQDVRHGNPLTQCRGFNLKAY---RNAAEIVQ--YGVKNNTTFLECAPKSPQASIKWLLQ 606

Query: 592 ----SHGPAAVPEASSTVYNGSLLLIVQDGVGGLYQCWATENGFSYPV 635
                     + E       G L+  VQ    GLY C ATEN F   +
Sbjct: 607 KDKDRRKEVKLNERIIATSQGLLIRSVQGSDQGLYHCIATENSFKQTI 654


>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
          Length = 1151

 Score =  267 bits (682), Expect = 3e-71
 Identities = 180/502 (35%), Positives = 273/502 (54%), Gaps = 34/502 (6%)

Query: 53  LSFFHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSE 112
           +S F   G +DF  L L   GN L VGAR  +  L + +     L     W +S+  +  
Sbjct: 115 VSNFTYPGARDFSQLALDPSGNQLIVGARNYLFRLSLANVS---LLQATEWASSEDTRRS 171

Query: 113 CAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEG 172
           C  K K+ E +C N++RVL+      ++ CGT AFSP CT  ++ +   L  + +K+  G
Sbjct: 172 CQSKGKTEE-ECQNYVRVLIVAG-RKVFMCGTNAFSPMCTSRQVGN---LSRTIEKI-NG 225

Query: 173 KGQSPFDPAHKHTAVLVD-GMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHD 230
             + P+DP H  TAV+   G LY+ T+ +F G +P + R+LGS P L+T  +  +WL+ +
Sbjct: 226 VARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQYNSKWLN-E 284

Query: 231 ASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQ 290
            +FVAA       YFF  E A E D    ++ SRVARVCKNDVGG  LL+  WTTF+KA+
Sbjct: 285 PNFVAAYDIGLFAYFFLRENAVEHDCGRTVY-SRVARVCKNDVGGRFLLEDTWTTFMKAR 343

Query: 291 LLCTQPGQLPF--NVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIER 348
           L C++PG++PF  N ++ A  LP        IY VFT+   V    +SAVCAF+L  I +
Sbjct: 344 LNCSRPGEVPFYYNELQSAFHLPEQD----LIYGVFTT--NVNSIAASAVCAFNLSAISQ 397

Query: 349 VFKGKYKELNKETSRWTTYRGPETNPRPGSC-SVGPS---SDKALTFMKDHFLMDE---Q 401
            F G ++      + W     P  N + G+    GP+   ++++L   +  FLM E    
Sbjct: 398 AFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRLFLMSEAVQP 457

Query: 402 VVGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAH--LVEE 459
           V   P + +  V ++ L V+  Q  D   H V+Y+GT +G++ KA+ +   S H   +EE
Sbjct: 458 VTPEPCVTQDSVRFSHLVVDLVQAKDTLYH-VLYIGTESGTILKALSTASRSLHGCYLEE 516

Query: 460 IQLFPD--PEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWD 517
           + + P    EP+R+L++  +  A+FVG   GV RVP   C+ Y S   C+ ARDP+C WD
Sbjct: 517 LHVLPPGRREPLRSLRILHSARALFVGLRDGVLRVPLERCAAYRSQGACLGARDPYCGWD 576

Query: 518 PESRTCCLL-SAPNLNSWKQDM 538
            + + C  L  + N++ W Q++
Sbjct: 577 GKQQRCSTLEDSSNMSLWTQNI 598


>gi|9910362 semaphorin sem2 [Homo sapiens]
          Length = 782

 Score =  263 bits (671), Expect = 6e-70
 Identities = 199/659 (30%), Positives = 314/659 (47%), Gaps = 65/659 (9%)

Query: 33  GGGQGP-----MPRVRYYAGD---ERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAREAI 84
           GG  GP     +PR+R    D     R+  F   +G  +   + L    + L++G  +A+
Sbjct: 19  GGSSGPSPGPSVPRLRLSYRDLLSANRSAIFLGPQGSLNLQAMYLDEYRDRLFLGGLDAL 78

Query: 85  LALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGT 144
            +L + D   P  + ++ WP    ++ EC  K +   T+C NF+RVL  +N THL  CGT
Sbjct: 79  YSLRL-DQAWPDPREVL-WPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGT 136

Query: 145 FAFSPACTFIEL--QDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFL 202
            AF P C  I +  +  ++L +    V  G+G+ P +P+    +  +DG LY+G   +FL
Sbjct: 137 GAFQPTCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFL 196

Query: 203 GSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAA--IPSTQ-----VVYFFFEETASEFD 255
           G E ++ R+ G +P L++D+    LH D  FV A  IP         VYFFF ET    D
Sbjct: 197 GREAMIFRSGGPRPALRSDSDQSLLH-DPRFVMAARIPENSDQDNDKVYFFFSETVPSPD 255

Query: 256 F-FERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPG----QLPFNVIRHAVLL 310
                +  SRV RVC ND GG+++L  KW+TFLKA+L+C+ PG    +  F+ +    LL
Sbjct: 256 GGSNHVTVSRVGRVCVNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLL 315

Query: 311 PADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGP 370
              +  +  +YA+F++   V   +  AVC + + DI  VF G +   +    +W  Y G 
Sbjct: 316 WPKAGKSLEVYALFSTVSAV--FQGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPYGGK 373

Query: 371 ETNPRPGSC-------------SVGPSSDKALTFMKDHFLMDEQV---VGTPLLVKSGV- 413
              PRPG C             S     D+ L F + H LM   V    G P+LVK+ + 
Sbjct: 374 VPFPRPGVCPSKMTAQPGRPFGSTKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLA 433

Query: 414 -EYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVV-----SGDSSAHLVEEIQLFPDPE 467
            +  ++ V+  +  DG ++ V++LGT +GS+ K +      S +    ++EE+Q+F  P 
Sbjct: 434 QQLHQIVVDRVEAEDG-TYDVIFLGTDSGSVLKVIALQAGGSAEPEEVVLEELQVFKVPT 492

Query: 468 PVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCAWDPESRTCCLL 526
           P+  ++++  +  ++VG   GV ++    C  Y  +C +C LARDP+CAWD  S T    
Sbjct: 493 PITEMEISVKRQMLYVGSRLGVAQLRLHQCETYGTACAECCLARDPYCAWDGASCTHYRP 552

Query: 527 SAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKE-VLAVPNSILELPCPHLSA 585
           S       +QD+  GNP   C    + +S   ++   +    V    ++   L C   S 
Sbjct: 553 SLGKRRFRRQDIRHGNPALQC----LGQSQEEEAVGLVAATMVYGTEHNSTFLECLPKSP 608

Query: 586 LASYYW------SHGPAAVPEASSTVY--NGSLLLIVQDGVGGLYQCWATENGFSYPVI 636
            A+  W        GP  V      ++   G L   +     G Y C   E+GFS  V+
Sbjct: 609 QAAVRWLLQRPGDEGPDQVKTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQTVV 667


>gi|147904700 semaphorin 5A [Homo sapiens]
          Length = 1074

 Score =  253 bits (645), Expect = 6e-67
 Identities = 171/498 (34%), Positives = 257/498 (51%), Gaps = 33/498 (6%)

Query: 56  FHQKGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLKNMIPWPASDRKKSECAF 115
           F  K   DF  L        L VGAR  +  L ++D     L   + W   +  K  C  
Sbjct: 50  FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLS---LIQAVEWECDEATKKACYS 106

Query: 116 KKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQ 175
           K KS E +C N+IRVL+      L+TCGT AF+P CT   L  S L  I +   + G  +
Sbjct: 107 KGKSKE-ECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSL--SNLTEIHDQ--ISGMAR 160

Query: 176 SPFDPAHKHTAVLV-DGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHDASF 233
            P+ P H  TA+L   G LY+ T  +F G +P + R+LG  P L+T  +  +WL+ + +F
Sbjct: 161 CPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLN-EPNF 219

Query: 234 VAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLC 293
           V++       YFFF E A E D  + +  SR ARVCKND+GG  LL+  WTTF+KA+L C
Sbjct: 220 VSSYDIGNFTYFFFRENAVEHDCGKTVF-SRAARVCKNDIGGRFLLEDTWTTFMKARLNC 278

Query: 294 TQPGQLPF--NVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFK 351
           ++PG++PF  N ++    L    P    IY +FT+   V    +SAVC F+L  I + F 
Sbjct: 279 SRPGEVPFYYNELQSTFFL----PELDLIYGIFTT--NVNSIAASAVCVFNLSAIAQAFS 332

Query: 352 GKYKELNKETSRWTTYRGPETNPRPGSCSVG---PSSDKALTFMKDHFLMDE---QVVGT 405
           G +K      S W  Y  P  + + G+   G     +++ L   +   LM E    V   
Sbjct: 333 GPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNLTERNLQDAQKFILMHEVVQPVTTV 392

Query: 406 PLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVV--SGDSSAHLVEEIQLF 463
           P  ++    ++ +AV+  QG +   H++ YL T  G++ K  V  +  SS+ L+EEI+LF
Sbjct: 393 PSFMEDNSRFSHVAVDVVQGREALVHII-YLATDYGTIKKVRVPLNQTSSSCLLEEIELF 451

Query: 464 PD--PEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCVDCVLARDPHCAWDPESR 521
           P+   EP+R+LQ+  +Q  +FVG    V ++P   C  Y +   C+ A+DP+C WD   +
Sbjct: 452 PERRREPIRSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMK 511

Query: 522 TCCLL-SAPNLNSWKQDM 538
            C  L  + ++  W+Q +
Sbjct: 512 KCTSLEESLSMTQWEQSI 529


>gi|6912650 semaphorin 3E [Homo sapiens]
          Length = 775

 Score =  252 bits (643), Expect = 1e-66
 Identities = 190/662 (28%), Positives = 300/662 (45%), Gaps = 63/662 (9%)

Query: 25  LLPTTTAGGGGQGPMPRVRYYAGD--ERRALSFFHQK-GLQDFDTLLLSGDGNTLYVGAR 81
           LL   T G       PR+R    +       S FH   G  D  T+LL      L+VG R
Sbjct: 16  LLELWTGGHTADTTHPRLRLSHKELLNLNRTSIFHSPFGFLDLHTMLLDEYQERLFVGGR 75

Query: 82  EAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYT 141
           + + +L ++   +      I WP++  K  EC  K K +  +C N++RVL  YN THL T
Sbjct: 76  DLVYSLSLER--ISDGYKEIHWPSTALKMEECIMKGK-DAGECANYVRVLHHYNRTHLLT 132

Query: 142 CGTFAFSPACTFIELQ---DSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTM 198
           CGT AF P C FI +    +  L  +   +   G+G+ PFDP+    + L+   L++G  
Sbjct: 133 CGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELFAGLY 192

Query: 199 NNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAA--IPSTQ-----VVYFFFEETA 251
           +++   +  + R++G    ++T++    L  +  FV +  IP  +      VYFFF E A
Sbjct: 193 SDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKA 252

Query: 252 SEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKAQLLCTQPG----QLPFNVIRHA 307
            E +       +RV R+C NDVGG+++L  KW+TFLKA+L+C+ PG       F+ +   
Sbjct: 253 LEAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDV 312

Query: 308 VLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTY 367
            LLP      P I+ +F +   +   R  A+C + +  I   F G Y         W+ Y
Sbjct: 313 FLLPTRDHKNPVIFGLFNTTSNI--FRGHAICVYHMSSIRAAFNGPYAHKEGPEYHWSVY 370

Query: 368 RGPETNPRPGSCSVGPSS----------DKALTFMKDHFLMDEQVVGT---PLLVKSGVE 414
            G    PRPGSC+   +           D A+ F + H LM + +      P+LVK+  +
Sbjct: 371 EGKVPYPRPGSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGK 430

Query: 415 YT--RLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAH-----LVEEIQLFPDPE 467
           Y   ++AV+  +  DG  + V+++GT  G + K +   +         ++EE+Q+F DP 
Sbjct: 431 YNLKQIAVDRVEAEDG-QYDVLFIGTDNGIVLKVITIYNQEMESMEEVILEELQIFKDPV 489

Query: 468 PVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYES-CVDCVLARDPHCAWDPESRTCCLL 526
           P+ +++++  +  +++G +  V +V   +C +Y S C DC LARDP+CAWD  S   C  
Sbjct: 490 PIISMEISSKRQQLYIGSASAVAQVRFHHCDMYGSACADCCLARDPYCAWDGIS---CSR 546

Query: 527 SAPNLNSWK-----QDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPCP 581
             P     K     QD+  GN    C           ++   +      + N+   L C 
Sbjct: 547 YYPTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHL---AYGIENNSTLLECT 603

Query: 582 HLSALASYYW--SHGPAAVPEASST------VYNGSLLLIVQDGVGGLYQCWATENGFSY 633
             S  A   W    G     E   T      +  G L L +     G Y C   E+ F +
Sbjct: 604 PRSLQAKVIWFVQKGRETRKEEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVH 663

Query: 634 PV 635
            V
Sbjct: 664 TV 665


>gi|11991660 sema domain, transmembrane domain (TM), and cytoplasmic
           domain, (semaphorin) 6A [Homo sapiens]
          Length = 1030

 Score =  244 bits (623), Expect = 2e-64
 Identities = 166/508 (32%), Positives = 262/508 (51%), Gaps = 49/508 (9%)

Query: 75  TLYVGAREAILALDIQDPGVPRL--KNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLV 132
           TLY+ AR+ I  +DI       +     + W +       C  K K  + +C NFI+VL+
Sbjct: 67  TLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQADVDTCRMKGKHKD-ECHNFIKVLL 125

Query: 133 SYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGM 192
             N   L+ CGT AF+P+C   ++    L P  ++    G  + P+D  H + A+  DG 
Sbjct: 126 KKNDDALFVCGTNAFNPSCRNYKMDT--LEPFGDE--FSGMARCPYDAKHANVALFADGK 181

Query: 193 LYSGTMNNFLGSEPILMRTLGSQPVLKT-DNFLRWLHHDASFVAAIPSTQVVYFFFEETA 251
           LYS T+ +FL  + ++ R+LG  P L+T  +  +WL  +  FV A+     +YFFF E A
Sbjct: 182 LYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWL-KEPYFVQAVDYGDYIYFFFREIA 240

Query: 252 SEFDFFERLHTSRVARVCKNDVGG-EKLLQKKWTTFLKAQLLCTQPG--QLPFNVIRHAV 308
            E++   ++   RVA+VCKND+GG +++L+K+WT+FLKA+L C+ PG     FN+++ AV
Sbjct: 241 VEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQ-AV 299

Query: 309 LLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKETSRWTTYR 368
                      + A F++ +       SAVCA+ +LDI  VF G++KE     S WT   
Sbjct: 300 TDVIRINGRDVVLATFSTPY--NSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVP 357

Query: 369 GPET-NPRPGSCSVGPSS-----------DKALTFMKDHFLMDE---QVVGTPLLVKSGV 413
                 PRPG C+ G SS           D  L F+K H LMDE    +   P  +++ V
Sbjct: 358 DERVPKPRPGCCA-GSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMV 416

Query: 414 EY--TRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAHL-----VEEIQLF--- 463
            Y  T++AV+TA G    +H V++LG+  G + K +    +S  L     +EE+ ++   
Sbjct: 417 RYRLTKIAVDTAAG-PYQNHTVVFLGSEKGIILKFLARIGNSGFLNDSLFLEEMSVYNSE 475

Query: 464 ------PDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESC-VDCVLARDPHCAW 516
                  + + +  +QL     +++V FS  V +VP   C  +  C   C+ +RDP+C W
Sbjct: 476 KCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVIKVPLGRCERHGKCKKTCIASRDPYCGW 535

Query: 517 DPESRTCCLLSAPNLNSWKQDMERGNPE 544
             E   C  LS  +  +++QD+ERGN +
Sbjct: 536 IKEGGACSHLSPNSRLTFEQDIERGNTD 563


>gi|19718780 semaphorin 6B precursor [Homo sapiens]
          Length = 888

 Score =  241 bits (614), Expect = 2e-63
 Identities = 168/555 (30%), Positives = 283/555 (50%), Gaps = 48/555 (8%)

Query: 59  KGLQDFDTLLLSGDGNTLYVGAREAILALDIQDPGVPRLK--NMIPWPASDRKKSECAFK 116
           +G  D +   +     TL++G R+ +  ++++ P    L+    + W ++    + C  K
Sbjct: 60  EGADDLNIQRVLRVNRTLFIGDRDNLYRVELEPPTSTELRYQRKLTWRSNPSDINVCRMK 119

Query: 117 KKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQS 176
            K  E +C NF++VL+  + + L+ CG+ AF+P C    +    L P+ ++  + G  + 
Sbjct: 120 GKQ-EGECRNFVKVLLLRDESTLFVCGSNAFNPVCANYSIDT--LQPVGDN--ISGMARC 174

Query: 177 PFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNFLRWLHHDASFVAA 236
           P+DP H + A+  DGML++ T+ +FL  + ++ R+LG +P L+T         +  FV A
Sbjct: 175 PYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHA 234

Query: 237 IPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGE-KLLQKKWTTFLKAQLLCTQ 295
           +     VYFFF E A EF++ E++  SRVARVCKNDVGG  ++L+K+WT+FLKA+L C+ 
Sbjct: 235 VEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSPRVLEKQWTSFLKARLNCSV 294

Query: 296 PG--QLPFNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGK 353
           PG     FNV++ AV         P + AVF++         SAVCAF L  +  VF+G+
Sbjct: 295 PGDSHFYFNVLQ-AVTGVVSLGGRPVVLAVFST--PSNSIPGSAVCAFDLTQVAAVFEGR 351

Query: 354 YKELNKETSRWTTYRGPET-NPRPGSCSV--------GPSSDKALTFMKDHFLMDEQVVG 404
           ++E     S WT     +   PRPG C+             D  L F+K H LMDE V  
Sbjct: 352 FREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSALPDDILNFVKTHPLMDEAVPS 411

Query: 405 ---TPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGDSSAH---- 455
               P ++++ + +  TR+AV+   G  G +  V++LG+  G++ K +V  ++S      
Sbjct: 412 LGHAPWILRTLMRHQLTRVAVDVGAGPWG-NQTVVFLGSEAGTVLKFLVRPNASTSGTSG 470

Query: 456 ---LVEEIQLF-PD----------PEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYE 501
               +EE + + PD           + + +L+L    G +   F   V RVP A C  Y 
Sbjct: 471 LSVFLEEFETYRPDRCGRPGGGETGQRLLSLELDAASGGLLAAFPRCVVRVPVARCQQYS 530

Query: 502 SCV-DCVLARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMSRSLRPQS 560
            C+ +C+ ++DP+C W P+  +C  LS     +++QD+   +         + R+   + 
Sbjct: 531 GCMKNCIGSQDPYCGWAPDG-SCIFLSPGTRAAFEQDVSGASTSGLGDCTGLLRASLSED 589

Query: 561 RPQIIKEVLAVPNSI 575
           R  ++   L V +S+
Sbjct: 590 RAGLVSVNLLVTSSV 604


>gi|24234741 semaphorin 6D isoform 4 precursor [Homo sapiens]
          Length = 1073

 Score =  234 bits (596), Expect = 3e-61
 Identities = 175/565 (30%), Positives = 281/565 (49%), Gaps = 59/565 (10%)

Query: 63  DFDTLLLSGDGNTLYVGAREAILALDIQD-PGVPRLKNM-IPWPASDRKKSECAFKKKSN 120
           DF  +L   D  TLY+  R+ +  +++ + P    + N  + W +  + +  CA K K  
Sbjct: 58  DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115

Query: 121 ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP 180
           + +C NFI+V V  N   ++ CGT AF+P C +  L         + + + G  + PFD 
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEY----DGEEISGLARCPFDA 170

Query: 181 AHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHDASFVAAIPS 239
              + A+  DG LYS T+ +FL S+ ++ R++G    L+T  +  +W+  +  F+ AI  
Sbjct: 171 RQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIK-EPHFLHAIEY 229

Query: 240 TQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGG-EKLLQKKWTTFLKAQLLCTQPGQ 298
              VYFFF E A E +   +   SRVAR+CKND+GG +++L+K WT+FLKA+L C+ PG 
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289

Query: 299 LPFNV-IRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKEL 357
             F   +  ++         P +  VFT+  Q+     SAVCAFS+ DIE+VFKG++KE 
Sbjct: 290 SFFYFDVLQSITDIIQINGIPTVVGVFTT--QLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 NKETSRWTTYRGPE---TNPRPGSCSVGPSS----------DKALTFMKDHFLMDEQV-- 402
               S WT    PE     PRPG C+    +          D+ L+F+K H LMD  V  
Sbjct: 348 KTPDSVWTAV--PEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPP 405

Query: 403 -VGTPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGD----SSAH 455
               P   K+ V Y  T ++V+ + G    ++ V+++G+  G + K +        + + 
Sbjct: 406 IADEPWFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV 464

Query: 456 LVEEIQLF---------PDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESC-VD 505
           L+EEI+ +          + + V +LQL     A++V FS  + R+P + C  Y SC   
Sbjct: 465 LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKS 524

Query: 506 CVLARDPHCAWDPESRTCCLLSAPNL--NSWKQDMERGNPEWACASGPMSRSLRPQSRPQ 563
           C+ +RDP+C W   S+  C    P +    ++QD E GN       G     L   + P 
Sbjct: 525 CIASRDPYCGW--LSQGSCGRVTPGMLAEGYEQDTEFGN---TAHLGDCHEILPTSTTPD 579

Query: 564 IIKEVLAVPNSILELPCPHLSALAS 588
              ++   P S +E+    ++ +AS
Sbjct: 580 Y--KIFGGPTSDMEVSSSSVTTMAS 602


>gi|24234744 semaphorin 6D isoform 5 precursor [Homo sapiens]
          Length = 597

 Score =  233 bits (594), Expect = 5e-61
 Identities = 167/519 (32%), Positives = 265/519 (51%), Gaps = 54/519 (10%)

Query: 63  DFDTLLLSGDGNTLYVGAREAILALDIQD-PGVPRLKNM-IPWPASDRKKSECAFKKKSN 120
           DF  +L   D  TLY+  R+ +  +++ + P    + N  + W +  + +  CA K K  
Sbjct: 58  DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115

Query: 121 ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP 180
           + +C NFI+V V  N   ++ CGT AF+P C +  L         + + + G  + PFD 
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEY----DGEEISGLARCPFDA 170

Query: 181 AHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHDASFVAAIPS 239
              + A+  DG LYS T+ +FL S+ ++ R++G    L+T  +  +W+  +  F+ AI  
Sbjct: 171 RQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIK-EPHFLHAIEY 229

Query: 240 TQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGG-EKLLQKKWTTFLKAQLLCTQPGQ 298
              VYFFF E A E +   +   SRVAR+CKND+GG +++L+K WT+FLKA+L C+ PG 
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289

Query: 299 LPFNV-IRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKEL 357
             F   +  ++         P +  VFT+  Q+     SAVCAFS+ DIE+VFKG++KE 
Sbjct: 290 SFFYFDVLQSITDIIQINGIPTVVGVFTT--QLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 NKETSRWTTYRGPE---TNPRPGSCSVGPSS----------DKALTFMKDHFLMDEQV-- 402
               S WT    PE     PRPG C+    +          D+ L+F+K H LMD  V  
Sbjct: 348 KTPDSVWTAV--PEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPP 405

Query: 403 -VGTPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGD----SSAH 455
               P   K+ V Y  T ++V+ + G    ++ V+++G+  G + K +        + + 
Sbjct: 406 IADEPWFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV 464

Query: 456 LVEEIQLF---------PDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESC-VD 505
           L+EEI+ +          + + V +LQL     A++V FS  + R+P + C  Y SC   
Sbjct: 465 LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKS 524

Query: 506 CVLARDPHCAWDPESRTCCLLSAPNL--NSWKQDMERGN 542
           C+ +RDP+C W   S+  C    P +    ++QD E GN
Sbjct: 525 CIASRDPYCGW--LSQGSCGRVTPGMLAEGYEQDTEFGN 561


>gi|24234738 semaphorin 6D isoform 3 precursor [Homo sapiens]
          Length = 1017

 Score =  233 bits (594), Expect = 5e-61
 Identities = 167/519 (32%), Positives = 265/519 (51%), Gaps = 54/519 (10%)

Query: 63  DFDTLLLSGDGNTLYVGAREAILALDIQD-PGVPRLKNM-IPWPASDRKKSECAFKKKSN 120
           DF  +L   D  TLY+  R+ +  +++ + P    + N  + W +  + +  CA K K  
Sbjct: 58  DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115

Query: 121 ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP 180
           + +C NFI+V V  N   ++ CGT AF+P C +  L         + + + G  + PFD 
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEY----DGEEISGLARCPFDA 170

Query: 181 AHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHDASFVAAIPS 239
              + A+  DG LYS T+ +FL S+ ++ R++G    L+T  +  +W+  +  F+ AI  
Sbjct: 171 RQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIK-EPHFLHAIEY 229

Query: 240 TQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGG-EKLLQKKWTTFLKAQLLCTQPGQ 298
              VYFFF E A E +   +   SRVAR+CKND+GG +++L+K WT+FLKA+L C+ PG 
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289

Query: 299 LPFNV-IRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKEL 357
             F   +  ++         P +  VFT+  Q+     SAVCAFS+ DIE+VFKG++KE 
Sbjct: 290 SFFYFDVLQSITDIIQINGIPTVVGVFTT--QLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 NKETSRWTTYRGPE---TNPRPGSCSVGPSS----------DKALTFMKDHFLMDEQV-- 402
               S WT    PE     PRPG C+    +          D+ L+F+K H LMD  V  
Sbjct: 348 KTPDSVWTAV--PEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPP 405

Query: 403 -VGTPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGD----SSAH 455
               P   K+ V Y  T ++V+ + G    ++ V+++G+  G + K +        + + 
Sbjct: 406 IADEPWFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV 464

Query: 456 LVEEIQLF---------PDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESC-VD 505
           L+EEI+ +          + + V +LQL     A++V FS  + R+P + C  Y SC   
Sbjct: 465 LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKS 524

Query: 506 CVLARDPHCAWDPESRTCCLLSAPNL--NSWKQDMERGN 542
           C+ +RDP+C W   S+  C    P +    ++QD E GN
Sbjct: 525 CIASRDPYCGW--LSQGSCGRVTPGMLAEGYEQDTEFGN 561


>gi|24234735 semaphorin 6D isoform 2 precursor [Homo sapiens]
          Length = 998

 Score =  233 bits (594), Expect = 5e-61
 Identities = 167/519 (32%), Positives = 265/519 (51%), Gaps = 54/519 (10%)

Query: 63  DFDTLLLSGDGNTLYVGAREAILALDIQD-PGVPRLKNM-IPWPASDRKKSECAFKKKSN 120
           DF  +L   D  TLY+  R+ +  +++ + P    + N  + W +  + +  CA K K  
Sbjct: 58  DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115

Query: 121 ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP 180
           + +C NFI+V V  N   ++ CGT AF+P C +  L         + + + G  + PFD 
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEY----DGEEISGLARCPFDA 170

Query: 181 AHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHDASFVAAIPS 239
              + A+  DG LYS T+ +FL S+ ++ R++G    L+T  +  +W+  +  F+ AI  
Sbjct: 171 RQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIK-EPHFLHAIEY 229

Query: 240 TQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGG-EKLLQKKWTTFLKAQLLCTQPGQ 298
              VYFFF E A E +   +   SRVAR+CKND+GG +++L+K WT+FLKA+L C+ PG 
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289

Query: 299 LPFNV-IRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKEL 357
             F   +  ++         P +  VFT+  Q+     SAVCAFS+ DIE+VFKG++KE 
Sbjct: 290 SFFYFDVLQSITDIIQINGIPTVVGVFTT--QLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 NKETSRWTTYRGPE---TNPRPGSCSVGPSS----------DKALTFMKDHFLMDEQV-- 402
               S WT    PE     PRPG C+    +          D+ L+F+K H LMD  V  
Sbjct: 348 KTPDSVWTAV--PEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPP 405

Query: 403 -VGTPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGD----SSAH 455
               P   K+ V Y  T ++V+ + G    ++ V+++G+  G + K +        + + 
Sbjct: 406 IADEPWFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV 464

Query: 456 LVEEIQLF---------PDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESC-VD 505
           L+EEI+ +          + + V +LQL     A++V FS  + R+P + C  Y SC   
Sbjct: 465 LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKS 524

Query: 506 CVLARDPHCAWDPESRTCCLLSAPNL--NSWKQDMERGN 542
           C+ +RDP+C W   S+  C    P +    ++QD E GN
Sbjct: 525 CIASRDPYCGW--LSQGSCGRVTPGMLAEGYEQDTEFGN 561


>gi|24234729 semaphorin 6D isoform 1 precursor [Homo sapiens]
          Length = 1011

 Score =  229 bits (584), Expect = 7e-60
 Identities = 159/491 (32%), Positives = 253/491 (51%), Gaps = 50/491 (10%)

Query: 63  DFDTLLLSGDGNTLYVGAREAILALDIQD-PGVPRLKNM-IPWPASDRKKSECAFKKKSN 120
           DF  +L   D  TLY+  R+ +  +++ + P    + N  + W +  + +  CA K K  
Sbjct: 58  DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115

Query: 121 ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP 180
           + +C NFI+V V  N   ++ CGT AF+P C +  L         + + + G  + PFD 
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEY----DGEEISGLARCPFDA 170

Query: 181 AHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHDASFVAAIPS 239
              + A+  DG LYS T+ +FL S+ ++ R++G    L+T  +  +W+  +  F+ AI  
Sbjct: 171 RQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIK-EPHFLHAIEY 229

Query: 240 TQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGG-EKLLQKKWTTFLKAQLLCTQPGQ 298
              VYFFF E A E +   +   SRVAR+CKND+GG +++L+K WT+FLKA+L C+ PG 
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289

Query: 299 LPFNV-IRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKEL 357
             F   +  ++         P +  VFT+  Q+     SAVCAFS+ DIE+VFKG++KE 
Sbjct: 290 SFFYFDVLQSITDIIQINGIPTVVGVFTT--QLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 NKETSRWTTYRGPE---TNPRPGSCSVGPSS----------DKALTFMKDHFLMDEQV-- 402
               S WT    PE     PRPG C+    +          D+ L+F+K H LMD  V  
Sbjct: 348 KTPDSVWTAV--PEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPP 405

Query: 403 -VGTPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGD----SSAH 455
               P   K+ V Y  T ++V+ + G    ++ V+++G+  G + K +        + + 
Sbjct: 406 IADEPWFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV 464

Query: 456 LVEEIQLF---------PDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESC-VD 505
           L+EEI+ +          + + V +LQL     A++V FS  + R+P + C  Y SC   
Sbjct: 465 LLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKS 524

Query: 506 CVLARDPHCAW 516
           C+ +RDP+C W
Sbjct: 525 CIASRDPYCGW 535


>gi|16306552 semaphorin Y [Homo sapiens]
          Length = 930

 Score =  218 bits (554), Expect = 2e-56
 Identities = 179/554 (32%), Positives = 271/554 (48%), Gaps = 67/554 (12%)

Query: 18  LFQLLQLLLPTTTAGGGGQGPMPRV----------RYYAGDERRALSFFHQKGLQDFDTL 67
           L  LL L LP T A    Q P+P +           ++ G E  A++       Q F TL
Sbjct: 11  LLLLLLLSLPHTQAAFP-QDPLPLLISDLQGTSPLSWFRGLEDDAVAAELGLDFQRFLTL 69

Query: 68  LLSGDGNTLYVGAREAILALDIQ--DPGVPRLKNM-IPWPASDRKKSECAFKKKSNETQC 124
                  TL V AR+ + + D+Q  + G   + N  + W + D +   CA + K  + +C
Sbjct: 70  -----NRTLLVAARDHVFSFDLQAEEEGEGLVPNKYLTWRSQDVEN--CAVRGKLTD-EC 121

Query: 125 FNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDPAHKH 184
           +N+IRVLV ++   L  CGT +FSP C    +         E + + G+ + PFD    +
Sbjct: 122 YNYIRVLVPWDSQTLLACGTNSFSPVCRSYGITSLQ----QEGEELSGQARCPFDATQSN 177

Query: 185 TAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHDASFVAAIPSTQVV 243
            A+  +G LYS T  +F  S+ ++ R+LG QP L++  +  +WL  +  FV A+     V
Sbjct: 178 VAIFAEGSLYSATAADFQASDAVVYRSLGPQPPLRSAKYDSKWLR-EPHFVQALEHGDHV 236

Query: 244 YFFFEETASEFDFFERLHTSRVARVCKNDVGGE-KLLQKKWTTFLKAQLLCTQPGQLPFN 302
           YFFF E + E     R+  SRVARVCK D+GG  + L + WT+FLK +L C+ PG   F 
Sbjct: 237 YFFFREVSVEDARLGRVQFSRVARVCKRDMGGSPRALDRHWTSFLKLRLNCSVPGDSTFY 296

Query: 303 V-IRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKELNKET 361
             +  A+  P +      ++ VFT+  Q      SAVCAF L +IER F+GK+KE     
Sbjct: 297 FDVLQALTGPVNLHGRSALFGVFTT--QTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLD 354

Query: 362 SRWTTYRGPET-NPRPGSCS-VGPSS---------DKALTFMKDHFLMDEQVVGTPLLVK 410
             WT        +PRPGSC+ VG ++         D  LTF+K H L+D  V   P+  +
Sbjct: 355 GAWTPVSEDRVPSPRPGSCAGVGGAALFSSSRDLPDDVLTFIKAHPLLDPAV--PPVTHQ 412

Query: 411 SGVEYTRLAVETAQGLDG----HSHL-VMYLGTTTGSLHKAVVSGDSSAH----LVEEIQ 461
             +  T  A+ T   +DG    HS++ VM+LG+  G++ K +  G  S      L+EEI 
Sbjct: 413 PLLTLTSRALLTQVAVDGMAGPHSNITVMFLGSNDGTVLKVLTPGGRSGGPEPILLEEID 472

Query: 462 LF-----------PDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVYESCV-DCVLA 509
            +                +  L+L      +FV FSG +  +P + C+ + +C   C+ +
Sbjct: 473 AYSPARCSGKRTAQTARRIIGLELDTEGHRLFVAFSGCIVYLPLSRCARHGACQRSCLAS 532

Query: 510 RDPHCAWDPESRTC 523
           +DP+C W   SR C
Sbjct: 533 QDPYCGWH-SSRGC 545


>gi|24234732 semaphorin 6D isoform 6 precursor [Homo sapiens]
          Length = 476

 Score =  197 bits (500), Expect = 4e-50
 Identities = 139/428 (32%), Positives = 222/428 (51%), Gaps = 40/428 (9%)

Query: 63  DFDTLLLSGDGNTLYVGAREAILALDIQD-PGVPRLKNM-IPWPASDRKKSECAFKKKSN 120
           DF  +L   D  TLY+  R+ +  +++ + P    + N  + W +  + +  CA K K  
Sbjct: 58  DFQLMLKIRD--TLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHK 115

Query: 121 ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP 180
           + +C NFI+V V  N   ++ CGT AF+P C +  L         + + + G  + PFD 
Sbjct: 116 D-ECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEY----DGEEISGLARCPFDA 170

Query: 181 AHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDNF-LRWLHHDASFVAAIPS 239
              + A+  DG LYS T+ +FL S+ ++ R++G    L+T  +  +W+  +  F+ AI  
Sbjct: 171 RQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIK-EPHFLHAIEY 229

Query: 240 TQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGG-EKLLQKKWTTFLKAQLLCTQPGQ 298
              VYFFF E A E +   +   SRVAR+CKND+GG +++L+K WT+FLKA+L C+ PG 
Sbjct: 230 GNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGD 289

Query: 299 LPFNV-IRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKGKYKEL 357
             F   +  ++         P +  VFT+  Q+     SAVCAFS+ DIE+VFKG++KE 
Sbjct: 290 SFFYFDVLQSITDIIQINGIPTVVGVFTT--QLNSIPGSAVCAFSMDDIEKVFKGRFKEQ 347

Query: 358 NKETSRWTTYRGPE---TNPRPGSCSVGPSS----------DKALTFMKDHFLMDEQV-- 402
               S WT    PE     PRPG C+    +          D+ L+F+K H LMD  V  
Sbjct: 348 KTPDSVWTAV--PEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPP 405

Query: 403 -VGTPLLVKSGVEY--TRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGD----SSAH 455
               P   K+ V Y  T ++V+ + G    ++ V+++G+  G + K +        + + 
Sbjct: 406 IADEPWFTKTRVRYRLTAISVDHSAG-PYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSV 464

Query: 456 LVEEIQLF 463
           L+EEI+ +
Sbjct: 465 LLEEIEAY 472


>gi|225637520 semaphorin 7A isoform 2 preproprotein [Homo sapiens]
          Length = 652

 Score =  166 bits (420), Expect = 7e-41
 Identities = 173/607 (28%), Positives = 259/607 (42%), Gaps = 87/607 (14%)

Query: 116 KKKSNETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQ 175
           K  S  T C N+I  L+      L  CGT A  P+C    L +  ++P+ E +     G 
Sbjct: 104 KNASVRTDCENYI-TLLERRSEGLLACGTNARHPSCW--NLVNGTVVPLGEMR-----GY 155

Query: 176 SPFDPAHKHTAVLVDGMLYSGTMNN--FLGSEPILMRTLG------SQPVLKTDNFLRW- 226
           +PF P  +++ VL +G     T+    + G  P   R  G      S  V++   F++  
Sbjct: 156 APFSP-DENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKAT 214

Query: 227 -LHHDASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQ-KKWT 284
            +H D ++         +Y+FF E   + +    L+ SRVA++C+ D GGE  L   KW 
Sbjct: 215 IVHQDQAY------DDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWN 268

Query: 285 TFLKAQLLCTQPG-QLPFNVIRHAVLLPADSP--TAPHIYAVFTSQWQVGGTRSSAVCAF 341
           TFLKA L+C+       FN ++   LLP  S       +Y VF++ W       SAVC +
Sbjct: 269 TFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----SAVCVY 323

Query: 342 SLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSC--SVGPSSDKALTFMKDHFLMD 399
           SL DI++VF+         TS    Y     NPRPG C     P   +       H  + 
Sbjct: 324 SLGDIDKVFR---------TSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVA 374

Query: 400 EQV-----VGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGD--- 451
           ++V     + TPL   S   Y ++AV   Q   G +  V+YL T  G++HK V  G+   
Sbjct: 375 QRVEPMGPLKTPLF-HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEH 433

Query: 452 SSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLAR 510
           S A  + EIQ F     ++ + L   +  ++V     V +VP   C VY   C  C+++R
Sbjct: 434 SFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSR 493

Query: 511 DPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLA 570
           DP+C WD   +  C+    +  S  Q +    P   C +       +P   P  +++V  
Sbjct: 494 DPYCGWD---QGRCISIYSSERSVLQSINPAEPHKECPNP------KPDKAP--LQKVSL 542

Query: 571 VPNSILELPCPHLSALASYYWSHGPAAVPEASSTVYNGSLLLIVQDGVG---GLYQCWAT 627
            PNS   L CP  S  A+Y W H             + + +L +++      G Y C A 
Sbjct: 543 APNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQ 602

Query: 628 ENGFSYPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALAAQQSYWPHFVTV 687
           E        SY+ ++Q   L   PE  GI  EH+         G A A   S W   +  
Sbjct: 603 EG-------SYFREAQHWQLL--PE-DGIMAEHLL--------GHACALAASLWLGVLPT 644

Query: 688 TVLFALV 694
             L  LV
Sbjct: 645 LTLGLLV 651


>gi|4504237 semaphorin 7A isoform 1 preproprotein [Homo sapiens]
          Length = 666

 Score =  164 bits (416), Expect = 2e-40
 Identities = 201/722 (27%), Positives = 304/722 (42%), Gaps = 114/722 (15%)

Query: 10  PWSLLGLFLFQLLQLLLPTTTAGGGGQGPM---PRV----RYYAGDERRALSFFHQKGLQ 62
           P + LGL L   L+LLL    A    QG +   PR+    + + G +R  + F    G  
Sbjct: 21  PPARLGLPL--RLRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDR--VDF----GQT 72

Query: 63  DFDTLLLSGDGNT-LYVGAREAILALDIQDPGVPRLKNMIPWPAS-DRKKSECAFKKKSN 120
           +  T+L    G++ ++VG R  +   D      P  KN      +    K  C  K+   
Sbjct: 73  EPHTVLFHEPGSSSVWVGGRGKVYLFDF-----PEGKNASVRTVNIGSTKGSCLDKR--- 124

Query: 121 ETQCFNFIRVLVSYNVTHLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKGQSPFDP 180
              C N+I  L+      L  CGT A  P+C    L +  ++P+ E +     G +PF P
Sbjct: 125 --DCENYI-TLLERRSEGLLACGTNARHPSCW--NLVNGTVVPLGEMR-----GYAPFSP 174

Query: 181 AHKHTAVLVDGMLYSGTMNN--FLGSEPILMRTLG------SQPVLKTDNFLRW--LHHD 230
             +++ VL +G     T+    + G  P   R  G      S  V++   F++   +H D
Sbjct: 175 -DENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQD 233

Query: 231 ASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQ-KKWTTFLKA 289
            ++         +Y+FF E   + +    L+ SRVA++C+ D GGE  L   KW TFLKA
Sbjct: 234 QAY------DDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKA 287

Query: 290 QLLCTQPG-QLPFNVIRHAVLLPADSP--TAPHIYAVFTSQWQVGGTRSSAVCAFSLLDI 346
            L+C+       FN ++   LLP  S       +Y VF++ W       SAVC +SL DI
Sbjct: 288 MLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----SAVCVYSLGDI 342

Query: 347 ERVFKGKYKELNKETSRWTTYRGPETNPRPGSC--SVGPSSDKALTFMKDHFLMDEQV-- 402
           ++VF+         TS    Y     NPRPG C     P   +       H  + ++V  
Sbjct: 343 DKVFR---------TSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEVAQRVEP 393

Query: 403 ---VGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGD---SSAHL 456
              + TPL   S   Y ++AV   Q   G +  V+YL T  G++HK V  G+   S A  
Sbjct: 394 MGPLKTPLF-HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGEQEHSFAFN 452

Query: 457 VEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCVLARDPHCA 515
           + EIQ F     ++ + L   +  ++V     V +VP   C VY   C  C+++RDP+C 
Sbjct: 453 IMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCLMSRDPYCG 512

Query: 516 WDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSI 575
           WD   +  C+    +  S  Q +    P   C +       +P   P  +++V   PNS 
Sbjct: 513 WD---QGRCISIYSSERSVLQSINPAEPHKECPNP------KPDKAP--LQKVSLAPNSR 561

Query: 576 LELPCPHLSALASYYWSHGPAAVPEASSTVYNGSLLLIVQDGVG---GLYQCWATENGFS 632
             L CP  S  A+Y W H             + + +L +++      G Y C A E    
Sbjct: 562 YYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFCEAQEG--- 618

Query: 633 YPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALAAQQSYWPHFVTVTVLFA 692
               SY+ ++Q   L   PE  GI  EH+         G A A   S W   +    L  
Sbjct: 619 ----SYFREAQHWQLL--PE-DGIMAEHLL--------GHACALAASLWLGVLPTLTLGL 663

Query: 693 LV 694
           LV
Sbjct: 664 LV 665


>gi|225637524 semaphorin 7A isoform 3 [Homo sapiens]
          Length = 501

 Score =  152 bits (385), Expect = 9e-37
 Identities = 156/550 (28%), Positives = 235/550 (42%), Gaps = 79/550 (14%)

Query: 173 KGQSPFDPAHKHTAVLVDGMLYSGTMNN--FLGSEPILMRTLG------SQPVLKTDNFL 224
           +G +PF P  +++ VL +G     T+    + G  P   R  G      S  V++   F+
Sbjct: 2   RGYAPFSP-DENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFI 60

Query: 225 RW--LHHDASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQ-K 281
           +   +H D ++         +Y+FF E   + +    L+ SRVA++C+ D GGE  L   
Sbjct: 61  KATIVHQDQAY------DDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVS 114

Query: 282 KWTTFLKAQLLCTQPG-QLPFNVIRHAVLLPADSP--TAPHIYAVFTSQWQVGGTRSSAV 338
           KW TFLKA L+C+       FN ++   LLP  S       +Y VF++ W       SAV
Sbjct: 115 KWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNY-----SAV 169

Query: 339 CAFSLLDIERVFKGKYKELNKETSRWTTYRGPETNPRPGSC--SVGPSSDKALTFMKDHF 396
           C +SL DI++VF+         TS    Y     NPRPG C     P   +       H 
Sbjct: 170 CVYSLGDIDKVFR---------TSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHP 220

Query: 397 LMDEQV-----VGTPLLVKSGVEYTRLAVETAQGLDGHSHLVMYLGTTTGSLHKAVVSGD 451
            + ++V     + TPL   S   Y ++AV   Q   G +  V+YL T  G++HK V  G+
Sbjct: 221 EVAQRVEPMGPLKTPLF-HSKYHYQKVAVHRMQASHGETFHVLYLTTDRGTIHKVVEPGE 279

Query: 452 ---SSAHLVEEIQLFPDPEPVRNLQLAPTQGAVFVGFSGGVWRVPRANCSVY-ESCVDCV 507
              S A  + EIQ F     ++ + L   +  ++V     V +VP   C VY   C  C+
Sbjct: 280 QEHSFAFNIMEIQPFRRAAAIQTMSLDAERRKLYVSSQWEVSQVPLDLCEVYGGGCHGCL 339

Query: 508 LARDPHCAWDPESRTCCLLSAPNLNSWKQDMERGNPEWACASGPMSRSLRPQSRPQIIKE 567
           ++RDP+C WD   +  C+    +  S  Q +    P   C +       +P   P  +++
Sbjct: 340 MSRDPYCGWD---QGRCISIYSSERSVLQSINPAEPHKECPNP------KPDKAP--LQK 388

Query: 568 VLAVPNSILELPCPHLSALASYYWSHGPAAVPEASSTVYNGSLLLIVQDGVG---GLYQC 624
           V   PNS   L CP  S  A+Y W H             + + +L +++      G Y C
Sbjct: 389 VSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCILFIENLTAQQYGHYFC 448

Query: 625 WATENGFSYPVISYWVDSQDQTLALDPELAGIPREHVKVPLTRVSGGAALAAQQSYWPHF 684
            A E        SY+ ++Q   L   PE  GI  EH+         G A A   S W   
Sbjct: 449 EAQEG-------SYFREAQHWQLL--PE-DGIMAEHLL--------GHACALAASLWLGV 490

Query: 685 VTVTVLFALV 694
           +    L  LV
Sbjct: 491 LPTLTLGLLV 500


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,800,920
Number of Sequences: 37866
Number of extensions: 1532550
Number of successful extensions: 3647
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 3359
Number of HSP's gapped (non-prelim): 64
length of query: 761
length of database: 18,247,518
effective HSP length: 110
effective length of query: 651
effective length of database: 14,082,258
effective search space: 9167549958
effective search space used: 9167549958
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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