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Search of human proteins with 21361176
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
(501 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 1019 0.0
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 759 0.0
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 734 0.0
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 702 0.0
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 671 0.0
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 671 0.0
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 665 0.0
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 467 e-131
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 464 e-131
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 344 9e-95
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 337 2e-92
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 268 9e-72
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 261 8e-70
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 252 5e-67
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 221 2e-57
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 205 7e-53
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 175 1e-43
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 153 4e-37
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 153 4e-37
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 153 4e-37
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 152 5e-37
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 152 5e-37
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 152 5e-37
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 139 8e-33
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 139 8e-33
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 135 7e-32
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 122 1e-27
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 122 1e-27
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 121 2e-27
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 119 6e-27
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 1019 bits (2634), Expect = 0.0
Identities = 501/501 (100%), Positives = 501/501 (100%)
Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60
MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV
Sbjct: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60
Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120
DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL
Sbjct: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120
Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180
NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI
Sbjct: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180
Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240
GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID
Sbjct: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240
Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300
KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG
Sbjct: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300
Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360
QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES
Sbjct: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360
Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420
GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR
Sbjct: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420
Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480
ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE
Sbjct: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480
Query: 481 YGFHEYTEVKTVTVKISQKNS 501
YGFHEYTEVKTVTVKISQKNS
Sbjct: 481 YGFHEYTEVKTVTVKISQKNS 501
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 759 bits (1959), Expect = 0.0
Identities = 361/493 (73%), Positives = 431/493 (87%)
Query: 9 LPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAAR 68
LP +L+I+YTKIFINNEW +S SG+ FPV+NPAT E++C+V+E DK D+DKAV+AAR
Sbjct: 26 LPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAAR 85
Query: 69 QAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIK 128
AF +GS WR MDASERGRLL KLADL+ERDR +LATMES+NGGK + A+ DL G IK
Sbjct: 86 LAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIK 145
Query: 129 TLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGN 188
T RY AGWADKI G TIP+DG++FT+TRHEPIGVCGQIIPWNFPL+M WKI PAL CGN
Sbjct: 146 TFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGN 205
Query: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248
TVV+KPAEQTPL+AL++ +LIKEAGFPPGV+NI+PGYGPTAGAAI+SH+ IDK+AFTGST
Sbjct: 206 TVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGST 265
Query: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASR 308
EVGKLI+EAAG+SNLKRVTLELGGKSP I+ ADADLD AVE AH GVF++QGQCC A SR
Sbjct: 266 EVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSR 325
Query: 309 IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL 368
IFVEESIY+EFVRRSVERAK+ ++G+P P QGPQIDK+QY+KIL+LI+SG EGAKL
Sbjct: 326 IFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKL 385
Query: 369 ECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGL 428
ECGG G KG+F++PTVFSNVTD+MRIAKEEIFGPVQ+I++FK++D+VI+RANN+ +GL
Sbjct: 386 ECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGL 445
Query: 429 SAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTE 488
A VFT DI+KA+T+SSA+QAGTVW+NCY ++AQ PFGGFKMSGNGRE+GE+G EY+E
Sbjct: 446 VAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSE 505
Query: 489 VKTVTVKISQKNS 501
VKTVTVKI QKNS
Sbjct: 506 VKTVTVKIPQKNS 518
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 734 bits (1896), Expect = 0.0
Identities = 350/494 (70%), Positives = 419/494 (84%)
Query: 7 PDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKA 66
P LP + +L++++TKIFINNEWH+S SGKKF NP+T E++C+VEEGDK DVDKAV+A
Sbjct: 18 PALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEA 77
Query: 67 ARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGC 126
A+ AFQ GSPWR +DA RGRLL++LADL+ERDR LA +E+M+ GK + +A+ DL GC
Sbjct: 78 AQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGC 137
Query: 127 IKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSC 186
I+TLRY AGWADKIQG+TIP D N +TRHEPIGVCG I PWNFPL+ML+WK+ PAL C
Sbjct: 138 IRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCC 197
Query: 187 GNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTG 246
GNT+V+KPAEQTPLTAL++ SLIKEAGFPPGVVNIVPG+GPT GAAISSH I+K+AFTG
Sbjct: 198 GNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTG 257
Query: 247 STEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAA 306
STEVGKL+KEAA +SNLKRVTLELGGK+PCIV ADADLD AVE AH GVF++QGQCC AA
Sbjct: 258 STEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAA 317
Query: 307 SRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGA 366
SR+FVEE +Y EFVRRSVE AKK +G+P QGPQID++Q+DKIL+LIESGKKEGA
Sbjct: 318 SRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGA 377
Query: 367 KLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFY 426
KLECGG +KG F++PTVFS VTD MRIAKEEIFGPVQ I+KFKS+++VIKRAN+T Y
Sbjct: 378 KLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDY 437
Query: 427 GLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEY 486
GL+A VFTK++DKA+ ++SAL++GTVW+NCY + AQ PFGGFKMSGNGRELGEY EY
Sbjct: 438 GLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEY 497
Query: 487 TEVKTVTVKISQKN 500
TEVKTVT+K+ KN
Sbjct: 498 TEVKTVTIKLGDKN 511
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 702 bits (1812), Expect = 0.0
Identities = 341/501 (68%), Positives = 408/501 (81%)
Query: 1 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDV 60
+S++ T +P ++ +IFINNEWHD+VS K FP NP+T E +CQV EGDKEDV
Sbjct: 17 LSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDV 76
Query: 61 DKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYL 120
DKAVKAAR AFQ+GSPWR MDAS RGRLL +LADLIERDR LA +E+++ GK Y +YL
Sbjct: 77 DKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYL 136
Query: 121 NDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKI 180
DL +K LRY AGWADK G+TIPIDG+FF+YTRHEP+GVCGQIIPWNFPL+M WK+
Sbjct: 137 VDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKL 196
Query: 181 GPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDID 240
GPAL+ GN VV+K AEQTPLTAL+VA+LIKEAGFPPGVVNIVPG+GPTAGAAI+SH D+D
Sbjct: 197 GPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVD 256
Query: 241 KVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQG 300
KVAFTGSTE+G++I+ AAG SNLKRVTLELGGKSP I+++DAD+D AVE AH +F++QG
Sbjct: 257 KVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQG 316
Query: 301 QCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIES 360
QCC A SR FV+E IYDEFV RSV RAK ++GNP QGPQ+D+ Q+ KIL I +
Sbjct: 317 QCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINT 376
Query: 361 GKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKR 420
GK+EGAKL CGGG ++GYF+QPTVF +V D M IAKEEIFGPV QI+KFK++++V+ R
Sbjct: 377 GKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGR 436
Query: 421 ANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGE 480
ANN+ YGL+A VFTKD+DKA +S ALQAGTVWVNCY V AQ PFGG+KMSG+GRELGE
Sbjct: 437 ANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGE 496
Query: 481 YGFHEYTEVKTVTVKISQKNS 501
YG YTEVKTVTVK+ QKNS
Sbjct: 497 YGLQAYTEVKTVTVKVPQKNS 517
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 671 bits (1732), Expect = 0.0
Identities = 324/500 (64%), Positives = 401/500 (80%), Gaps = 2/500 (0%)
Query: 2 SSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVD 61
SS+ P+L D I Y ++FINNEW D+VS K FP NP T E + V EGD+ DVD
Sbjct: 20 SSAAALPSPILNPD--IPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVD 77
Query: 62 KAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLN 121
+AVKAAR+AF++GSPWR MDASERGRLL +LADL+ERDR+ LA++E+++ GK + +Y
Sbjct: 78 RAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYAL 137
Query: 122 DLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIG 181
DL IK RY AGWADK G+TIP+DG F +TRHEP+GVCGQIIPWNFPLVM WK+
Sbjct: 138 DLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLA 197
Query: 182 PALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDK 241
PAL+ GNTVV+K AEQTPL+AL++ASLIKEAGFPPGVVNI+ GYGPTAGAAI+ H+D+DK
Sbjct: 198 PALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDK 257
Query: 242 VAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQ 301
VAFTGSTEVG LI++AAG SNLKRVTLELGGKSP IVLADAD+++AVE H +F++ GQ
Sbjct: 258 VAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQ 317
Query: 302 CCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESG 361
CC A SR FVEESIY+EF+ R+VE+AK+ +GNP QGPQ+DKEQ++++L I+ G
Sbjct: 318 CCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLG 377
Query: 362 KKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRA 421
+KEGAKL CGG +G +G+F++PTVF V D+MRIAKEEIFGPVQ + KFK +++V++RA
Sbjct: 378 QKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERA 437
Query: 422 NNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEY 481
NNT YGL+A VFT+D+DKA+ + ALQAGTVWVN Y +V+ PFGGFK SGNGRELGE
Sbjct: 438 NNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGED 497
Query: 482 GFHEYTEVKTVTVKISQKNS 501
G YTEVKTVT+K+ QKNS
Sbjct: 498 GLKAYTEVKTVTIKVPQKNS 517
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 671 bits (1730), Expect = 0.0
Identities = 329/493 (66%), Positives = 394/493 (79%), Gaps = 38/493 (7%)
Query: 9 LPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAAR 68
LP +L+I+YTKIFINNEW +S SG+ FPV+NPAT E++C+V+E DK D+DKAV+AAR
Sbjct: 26 LPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAAR 85
Query: 69 QAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIK 128
AF +GS WR MDASERGRLL KLADL+ERDR +LATMES+NGGK + A+ DL G IK
Sbjct: 86 LAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIK 145
Query: 129 TLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGN 188
T RY AGWADKI G TIP+DG++FT+TRHEPIGVCGQIIPWNFPL+M WKI PAL CGN
Sbjct: 146 TFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGN 205
Query: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248
TVV+KPAEQTPL+AL++ +LIKE
Sbjct: 206 TVVIKPAEQTPLSALYMGALIKE------------------------------------- 228
Query: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASR 308
VGKLI+EAAG+SNLKRVTLELGGKSP I+ ADADLD AVE AH GVF++QGQCC A SR
Sbjct: 229 -VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSR 287
Query: 309 IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL 368
IFVEESIY+EFVRRSVERAK+ ++G+P P QGPQIDK+QY+KIL+LI+SG EGAKL
Sbjct: 288 IFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKL 347
Query: 369 ECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGL 428
ECGG G KG+F++PTVFSNVTD+MRIAKEEIFGPVQ+I++FK++D+VI+RANN+ +GL
Sbjct: 348 ECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGL 407
Query: 429 SAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTE 488
A VFT DI+KA+T+SSA+QAGTVW+NCY ++AQ PFGGFKMSGNGRE+GE+G EY+E
Sbjct: 408 VAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSE 467
Query: 489 VKTVTVKISQKNS 501
VKTVTVKI QKNS
Sbjct: 468 VKTVTVKIPQKNS 480
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 665 bits (1717), Expect = 0.0
Identities = 317/422 (75%), Positives = 374/422 (88%)
Query: 80 MDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADK 139
MDASERGRLL KLADL+ERDR +LATMES+NGGK + A+ DL G IKT RY AGWADK
Sbjct: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
Query: 140 IQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199
I G TIP+DG++FT+TRHEPIGVCGQIIPWNFPL+M WKI PAL CGNTVV+KPAEQTP
Sbjct: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
Query: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAG 259
L+AL++ +LIKEAGFPPGV+NI+PGYGPTAGAAI+SH+ IDK+AFTGSTEVGKLI+EAAG
Sbjct: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
Query: 260 KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEF 319
+SNLKRVTLELGGKSP I+ ADADLD AVE AH GVF++QGQCC A SRIFVEESIY+EF
Sbjct: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
Query: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKG 379
VRRSVERAK+ ++G+P P QGPQIDK+QY+KIL+LI+SG EGAKLECGG G KG
Sbjct: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
Query: 380 YFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDK 439
+F++PTVFSNVTD+MRIAKEEIFGPVQ+I++FK++D+VI+RANN+ +GL A VFT DI+K
Sbjct: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
Query: 440 AITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQK 499
A+T+SSA+QAGTVW+NCY ++AQ PFGGFKMSGNGRE+GE+G EY+EVKTVTVKI QK
Sbjct: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
Query: 500 NS 501
NS
Sbjct: 421 NS 422
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 467 bits (1201), Expect = e-131
Identities = 240/486 (49%), Positives = 327/486 (67%), Gaps = 8/486 (1%)
Query: 16 LKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGS 75
+K+ Y + FIN ++ D+ GK + NP +C+V DVDKAV AA+ AF+ G
Sbjct: 439 VKMPY-QCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE 497
Query: 76 PWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAG 135
W M+A ERGRL+Y+LADL+E ++ LAT+E+++ G +Y+ A + ++T RY AG
Sbjct: 498 -WGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAG 556
Query: 136 WADKIQGRTIPID----GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV 191
W DKIQG TIPI+ T+T+ EP+GVC IIPWN+PL+ML WK L+ GNT+V
Sbjct: 557 WCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLV 616
Query: 192 VKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG 251
+KPA+ TPLTAL A L +AGFP GV+NI+PG G AG +S H DI K+ FTGST +G
Sbjct: 617 LKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIG 676
Query: 252 KLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFV 311
K I ++ SNLK+V+LELGGKSP I+ D +LD AV VF+++G+ CIAA R+FV
Sbjct: 677 KQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFV 736
Query: 312 EESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECG 371
EESI+DEFV R VE KK +G+PL GPQ K +K+L E+G KEGA L G
Sbjct: 737 EESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYG 796
Query: 372 GGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKS--LDDVIKRANNTFYGLS 429
G G+F++PTVF++V D M +AKEE FGP+ I KF++ +D V++RAN+T YGL+
Sbjct: 797 GRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLA 856
Query: 430 AGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEV 489
+GVFT+DI+KA+ +S L+AGTV++N Y PFGG K SG G++LGE +EY +
Sbjct: 857 SGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKT 916
Query: 490 KTVTVK 495
KTVT++
Sbjct: 917 KTVTLE 922
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 464 bits (1194), Expect = e-131
Identities = 242/478 (50%), Positives = 315/478 (65%), Gaps = 7/478 (1%)
Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81
++FI E+ D+ K NP +CQV DVDKAV AA+ AF+ G W +
Sbjct: 423 QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKIS 481
Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141
A +RGRL+Y+LADL+E+ + LAT+E+++ G +Y+ A + I+T RY AGW DKIQ
Sbjct: 482 ARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQ 541
Query: 142 GRTIPID----GNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQ 197
G TIPI+ T TR EP+GVCG IIPWN+PL+ML WK L+ GNTVV+KPA+
Sbjct: 542 GSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQV 601
Query: 198 TPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEA 257
TPLTAL A L +AG P GVVN++PG G G +S H D+ K+ FTGSTEVGK I ++
Sbjct: 602 TPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
Query: 258 AGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYD 317
SN+K+V+LELGGKSP I+ AD DL+ AV+ VF+++G+ CIAA R+FVE+SI+D
Sbjct: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
Query: 318 EFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGN 377
EFVRR VE +K +GNPL GPQ K+++ + G KEGA L CGG
Sbjct: 722 EFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR 781
Query: 378 KGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFK--SLDDVIKRANNTFYGLSAGVFTK 435
G+F +PTVF++V D M IAKEE FGPV I +F LD V+ RAN T +GL++GVFT+
Sbjct: 782 PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTR 841
Query: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVT 493
DI+KA+ +S LQAGTV+VN Y PFGGFK SG G++LGE +EY VKTVT
Sbjct: 842 DINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVT 899
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 344 bits (883), Expect = 9e-95
Identities = 190/467 (40%), Positives = 276/467 (59%), Gaps = 12/467 (2%)
Query: 41 FNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDR 100
F PAT + +++V+ AV+ A+ AF+I W ER R+L + A +I
Sbjct: 56 FEPATGRVIATFTCSGEKEVNLAVQNAKAAFKI---WSQKSGMERCRILLEAARIIRERE 112
Query: 101 LLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTYTRHEPI 160
+ATME +N GK A L D+ + L Y AG A + G I + G F YTR EP+
Sbjct: 113 DEIATMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPL 171
Query: 161 GVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVN 220
GVC I WN+P + WK PAL+CGN +V KP+ TP++AL +A + EAG PPG+ N
Sbjct: 172 GVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFN 231
Query: 221 IVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLA 280
+V G G G + H D+ KV+FTGS G I E + K +K VTLELGGKSP I+ +
Sbjct: 232 VVQG-GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG-IKPVTLELGGKSPLIIFS 289
Query: 281 DADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGV 340
D D++NAV+ A F QGQ C +R+FV++ I D+F V++ ++ +G+PL
Sbjct: 290 DCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDT 349
Query: 341 TQGPQIDKEQYDKILDLIESGKKEGAKLECGGG------PWGNKGYFVQPTVFSNVTDEM 394
GP I++ +++L ++ K++GAK+ CGG P GY+++P V +N D+M
Sbjct: 350 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDM 409
Query: 395 RIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWV 454
KEEIFGPV I+ F + +V++RAN+T +GL+AGVFT+DI +A + + LQAGT ++
Sbjct: 410 TCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFI 469
Query: 455 NCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKISQKNS 501
N Y V + PFGG+K SG GRE G Y+++KTV V++ S
Sbjct: 470 NNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVES 516
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 337 bits (864), Expect = 2e-92
Identities = 183/463 (39%), Positives = 275/463 (59%), Gaps = 12/463 (2%)
Query: 41 FNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDR 100
++P+T E C+V K++++ AVKAAR+AF W + ER R+L ++ADL+E+
Sbjct: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFP---SWSSRSPQERSRVLNQVADLLEQSL 84
Query: 101 LLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDG-NFFTYTRHEP 159
A ES + GK + A D+ ++ R+ A + +D YT P
Sbjct: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAP 144
Query: 160 IGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVV 219
+GV G I PWN PL +L WKI PA++ GNTV+ KP+E T +TA + L+ +AG PPGVV
Sbjct: 145 VGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVV 204
Query: 220 NIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVL 279
NIV G GP G A+ SH ++ ++FTGS + I + + + K+++LELGGK+P I+
Sbjct: 205 NIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAIIF 263
Query: 280 ADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPG 339
DA+LD + F +QG+ C+ SRIFV++SIY EF++R VE +K+ +G P P
Sbjct: 264 EDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPL 323
Query: 340 VTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG------PWGNK-GYFVQPTVFSNVTD 392
V+ G I K +K+ ++ EGA++ CG G P N+ GYF+ PTV +++ D
Sbjct: 324 VSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKD 383
Query: 393 EMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTV 452
E EEIFGPV ++ F S ++VI+RANN YGL+A V++ ++ + ++ LQ+G V
Sbjct: 384 ESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLV 443
Query: 453 WVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495
W NC+ + PFGG K SG GRE + + +TE+KT+TVK
Sbjct: 444 WTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 268 bits (685), Expect = 9e-72
Identities = 164/463 (35%), Positives = 243/463 (52%), Gaps = 66/463 (14%)
Query: 41 FNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDR 100
++P+T E C+V K++++ AVKAAR+AF W + ER R+L ++ADL+E+
Sbjct: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFP---SWSSRSPQERSRVLNQVADLLEQSL 84
Query: 101 LLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDG-NFFTYTRHEP 159
A ES + GK + A D+ ++ R+ A + +D YT P
Sbjct: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAP 144
Query: 160 IGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVV 219
+GV G I PWN PL +L WKI PA++ GNTV+ KP+E T +TA + L+ +AG PPGVV
Sbjct: 145 VGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVV 204
Query: 220 NIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVL 279
NIV G GP G A+ SH ++ ++FTGS + I + + + K+++LELGGK+P I+
Sbjct: 205 NIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAIIF 263
Query: 280 ADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPG 339
DA+LD + F +Q VR V+RA
Sbjct: 264 EDANLDECIPATVRSSFANQ--------------------VRSYVKRA------------ 291
Query: 340 VTQGPQIDKEQYDKILDLIESGKKEGAKLECGGG------PWGNK-GYFVQPTVFSNVTD 392
EGA++ CG G P N+ GYF+ PTV +++ D
Sbjct: 292 ----------------------LAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKD 329
Query: 393 EMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTV 452
E EEIFGPV ++ F S ++VI+RANN YGL+A V++ ++ + ++ LQ+G V
Sbjct: 330 ESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLV 389
Query: 453 WVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495
W NC+ + PFGG K SG GRE + + +TE+KT+TVK
Sbjct: 390 WTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 261 bits (668), Expect = 8e-70
Identities = 170/477 (35%), Positives = 253/477 (53%), Gaps = 12/477 (2%)
Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80
T F+ W + + FPV +PA+ L V + + AV+AA +AF WR +
Sbjct: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREV 115
Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140
A ER LL K +L+ +++ LA + + GK A+ L L + + A ++
Sbjct: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174
Query: 141 QGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199
G I + +PIGV I PWNFP M+ K+G AL+ G TVVVKPAE TP
Sbjct: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234
Query: 200 LTALHVASLIKEAGFPPGVVNIVPGYGPTA---GAAISSHMDIDKVAFTGSTEVGKLIKE 256
+AL +A L +AG P GV N++P A G AI + + K++FTGST GK++
Sbjct: 235 FSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLH 294
Query: 257 AAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIY 316
A S +KRV++ELGG +P IV A++D AV A F + GQ C+ +++ V+ I+
Sbjct: 295 HAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIH 353
Query: 317 DEFVRRSVERAKKYI-LGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPW 375
D FV+ E KK + +GN G TQGP I+++ +K+ + +GA + GG
Sbjct: 354 DAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRH 413
Query: 376 GNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435
F +PT+ NVT +M EE FGP+ ++KF + ++ I AN GL+ +++
Sbjct: 414 QLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQ 473
Query: 436 DIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTV 492
D + ++ L+ G V VN + S +CPFGG K SG GRE +YG EY E+K V
Sbjct: 474 DPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYV 530
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 252 bits (644), Expect = 5e-67
Identities = 170/490 (34%), Positives = 253/490 (51%), Gaps = 25/490 (5%)
Query: 21 TKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTM 80
T F+ W + + FPV +PA+ L V + + AV+AA +AF WR +
Sbjct: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAF---CRWREV 115
Query: 81 DASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKI 140
A ER LL K +L+ +++ LA + + GK A+ L L + + A ++
Sbjct: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAF-FLEWFSEEARRV 174
Query: 141 QGRTIPIDG-NFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTP 199
G I + +PIGV I PWNFP M+ K+G AL+ G TVVVKPAE TP
Sbjct: 175 YGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTP 234
Query: 200 LTALHVAS-------------LIKEAGFPPGVVNIVPGYGPTA---GAAISSHMDIDKVA 243
+AL +A L +AG P GV N++P A G AI + + K++
Sbjct: 235 FSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKIS 294
Query: 244 FTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCC 303
FTGST GK++ A S +KRV++ELGG +P IV A++D AV A F + GQ C
Sbjct: 295 FTGSTTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTC 353
Query: 304 IAASRIFVEESIYDEFVRRSVERAKKYI-LGNPLTPGVTQGPQIDKEQYDKILDLIESGK 362
+ +++ V+ I+D FV+ E KK + +GN G TQGP I+++ +K+ +
Sbjct: 354 VCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAV 413
Query: 363 KEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRAN 422
+GA + GG F +PT+ NVT +M EE FGP+ ++KF + ++ I AN
Sbjct: 414 SKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIAN 473
Query: 423 NTFYGLSAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYG 482
GL+ +++D + ++ L+ G V VN + S +CPFGG K SG GRE +YG
Sbjct: 474 AADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYG 533
Query: 483 FHEYTEVKTV 492
EY E+K V
Sbjct: 534 IDEYLELKYV 543
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 221 bits (562), Expect = 2e-57
Identities = 150/489 (30%), Positives = 251/489 (51%), Gaps = 17/489 (3%)
Query: 22 KIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMD 81
K+FI ++ +S S K + NPAT E + +V + K ++D A+ + ++AF W
Sbjct: 41 KLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPA---WADTS 97
Query: 82 ASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQ 141
R ++L + LI+ + +A + ++ GK ++A D+ ++ + + +
Sbjct: 98 VLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAE-GDVFRGLQVVEHACSVTSLMM 156
Query: 142 GRTIP-IDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200
G T+P I + Y+ P+GVC I P+NFP ++ +W A+ CGNT ++KP+E+ P
Sbjct: 157 GETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPG 216
Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260
+ +A L++++G P G +NI+ G I H DI ++F GS + G+ I E G
Sbjct: 217 ATMLLAKLLQDSGAPDGTLNIIHGQHEAVN-FICDHPDIKAISFVGSNKAGEYIFE-RGS 274
Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAAS-RIFVEESIYDEF 319
+ KRV +G K+ +V+ DA+ +N + F GQ C+A S + V E+ ++
Sbjct: 275 RHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKW 332
Query: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKG 379
+ VE AK + PG GP I + +++ +LI+SG KEGA + G KG
Sbjct: 333 LPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKG 392
Query: 380 Y----FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTK 435
Y FV PT+ SNV M KEEIFGPV +++ ++LD+ I+ NN YG +FT
Sbjct: 393 YENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTT 452
Query: 436 DIDKAITISSALQAGTVWVNC-YGVVSAQCPFGGFKMS--GNGRELGEYGFHEYTEVKTV 492
+ A + + G V VN V F G + S G+ G+ G YT++KT+
Sbjct: 453 NGATARKYAHLVDVGQVGVNVPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTI 512
Query: 493 TVKISQKNS 501
T + ++++
Sbjct: 513 TSQWKEEDA 521
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 205 bits (522), Expect = 7e-53
Identities = 141/481 (29%), Positives = 227/481 (47%), Gaps = 32/481 (6%)
Query: 35 GKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLAD 94
G+ + PA E + +V + D ++ VK AR+A++I W + A +RG ++ ++ D
Sbjct: 63 GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKI---WADIPAPKRGEIVRQIGD 119
Query: 95 LIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIPIDGNFFTY 154
+ +L ++ S+ GK+ + ++ + Y G + I G +P + +
Sbjct: 120 ALREKIQVLGSLVSLEMGKILVEG-VGEVQEYVDICDYAVGLSRMIGGPILPSERSGHAL 178
Query: 155 TRH-EPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIK--- 210
P+G+ G I +NFP+ + W A+ CGN + K A T L ++ V +I
Sbjct: 179 IEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVL 238
Query: 211 EAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGK----LIKEAAGKSNLKRV 266
E PG + + G G A++ ++ ++FTGST+VGK +++E G+S
Sbjct: 239 EDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRS----- 293
Query: 267 TLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVER 326
LELGG + I DADL V A GQ C A R+F+ ESI+DE V R +
Sbjct: 294 LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKA 353
Query: 327 AKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTV 386
+ +GNP P V GP K+ L +E KKEG + GG G +V+PT+
Sbjct: 354 YAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTI 413
Query: 387 FSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSA 446
+ + + IA E F P+ + KFK+ ++V N GLS+ +FTKD+ +
Sbjct: 414 VTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFR---- 469
Query: 447 LQAGTVWVNCYGVVSAQCP---------FGGFKMSGNGRELGEYGFHEYTEVKTVTVKIS 497
G +C G+V+ P FGG K +G GRE G + +Y T T+ S
Sbjct: 470 -WLGPKGSDC-GIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYS 527
Query: 498 Q 498
+
Sbjct: 528 K 528
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 175 bits (443), Expect = 1e-43
Identities = 141/477 (29%), Positives = 225/477 (47%), Gaps = 27/477 (5%)
Query: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDAS 83
++N +W P +P T E L + EDV AV+AAR AF+ W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
Query: 84 ERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGR 143
R + L +LA++I++ + LL T+ES+ G+ D+ + L Y A IQ
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAS 154
Query: 144 TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV--VKPAEQTPLT 201
T EP+GV G I+P F + ++W+I PAL+ G TVV V PA PL
Sbjct: 155 T-----QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLL 209
Query: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261
+A L E G PG++N++ G ++S I KVAF G+ E G+ ++ +
Sbjct: 210 ---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLA-G 264
Query: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVR 321
+ L LG +S ++ AD+D+AVE + +G R+ ++ES++DE +R
Sbjct: 265 ECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMR 321
Query: 322 RSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL-ECGGGPWGNKGY 380
R ER + G L V G + D + + + +GA++ + G P ++
Sbjct: 322 RLQERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVP--SERP 378
Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440
F PT+ SN+ A+ E+ PV F++ + + AN T G SA V+++ + +A
Sbjct: 379 FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQA 438
Query: 441 ITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKIS 497
+ + LQ GTVW+N +G+ P GG K SG G G +EY ++S
Sbjct: 439 LELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLS 495
Score = 89.0 bits (219), Expect = 9e-18
Identities = 70/223 (31%), Positives = 103/223 (46%), Gaps = 13/223 (5%)
Query: 52 VEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG 111
V EG +D+ AV+AA QAF W R LL+ LA +ER + LA+ G
Sbjct: 558 VAEGGAKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQG 614
Query: 112 GKLYSNAYLNDLAGCIKTLRYCAGWADKIQ--GRTIPIDGNFFTYTR-HEPIGVCGQIIP 168
+L + +L+ R W ++Q G T+ + G R EP+GV + P
Sbjct: 615 AELKAAEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCP 669
Query: 169 WNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPT 228
+PL+ + + PAL+ GNTVV+ P+ PL AL V + FP G+ N+V G
Sbjct: 670 DEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDH 728
Query: 229 AGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELG 271
++ H D+ + + GS + G E A NLK V G
Sbjct: 729 LTRCLALHQDVQAMWYFGSAQ-GSQFVEWASAGNLKPVWASRG 770
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 153 bits (386), Expect = 4e-37
Identities = 129/444 (29%), Positives = 207/444 (46%), Gaps = 28/444 (6%)
Query: 56 DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG-GKL 114
DK ++KA++AA A + W ++R ++ K AD++ R ++M G GK
Sbjct: 98 DKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 154
Query: 115 YSNAYLNDLAGCIKTLRYCAGWADKIQGR---TIPIDGNFFTYTRHEPIGVCGQIIPWNF 171
A ++ A I R+ A +A +++G+ ++P N Y E G I P+NF
Sbjct: 155 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 212
Query: 172 PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGA 231
+ PAL GN V+ KP++ L + V +++EAG PP ++ VP GP G
Sbjct: 213 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 271
Query: 232 AISSHMDIDKVAFTGSTEVGK-LIKEAAGK----SNLKRVTLELGGKSPCIVLADADLDN 286
++S + + FTGS K L K+ A R+ E GGK+ V AD+++
Sbjct: 272 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 331
Query: 287 AVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP-GVTQGPQ 345
V F + GQ C A SR++V S++ + R +E + +G+P G
Sbjct: 332 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 391
Query: 346 IDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-GYFVQPTVFSNVTDEMRIAKEEIFGP 404
ID + + +I +E + + GG + GYFV+P + + + I KEEIFGP
Sbjct: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 451
Query: 405 VQQIMKFKSLDDVIKRA-----NNTFYGLSAGVFTKDIDKAITISSALQ--AGTVWVN-- 455
V + + DD K + T YGL+ VF++D D + L+ AG ++N
Sbjct: 452 VLSVYVYP--DDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 509
Query: 456 CYGVVSAQCPFGGFKMSGNGRELG 479
G + Q PFGG + SG + G
Sbjct: 510 STGSIVGQQPFGGARASGTNDKPG 533
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 153 bits (386), Expect = 4e-37
Identities = 129/444 (29%), Positives = 207/444 (46%), Gaps = 28/444 (6%)
Query: 56 DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG-GKL 114
DK ++KA++AA A + W ++R ++ K AD++ R ++M G GK
Sbjct: 38 DKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 94
Query: 115 YSNAYLNDLAGCIKTLRYCAGWADKIQGR---TIPIDGNFFTYTRHEPIGVCGQIIPWNF 171
A ++ A I R+ A +A +++G+ ++P N Y E G I P+NF
Sbjct: 95 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 152
Query: 172 PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGA 231
+ PAL GN V+ KP++ L + V +++EAG PP ++ VP GP G
Sbjct: 153 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 211
Query: 232 AISSHMDIDKVAFTGSTEVGK-LIKEAAGK----SNLKRVTLELGGKSPCIVLADADLDN 286
++S + + FTGS K L K+ A R+ E GGK+ V AD+++
Sbjct: 212 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 271
Query: 287 AVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP-GVTQGPQ 345
V F + GQ C A SR++V S++ + R +E + +G+P G
Sbjct: 272 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 331
Query: 346 IDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-GYFVQPTVFSNVTDEMRIAKEEIFGP 404
ID + + +I +E + + GG + GYFV+P + + + I KEEIFGP
Sbjct: 332 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 391
Query: 405 VQQIMKFKSLDDVIKRA-----NNTFYGLSAGVFTKDIDKAITISSALQ--AGTVWVN-- 455
V + + DD K + T YGL+ VF++D D + L+ AG ++N
Sbjct: 392 VLSVYVYP--DDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 449
Query: 456 CYGVVSAQCPFGGFKMSGNGRELG 479
G + Q PFGG + SG + G
Sbjct: 450 STGSIVGQQPFGGARASGTNDKPG 473
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 153 bits (386), Expect = 4e-37
Identities = 129/444 (29%), Positives = 207/444 (46%), Gaps = 28/444 (6%)
Query: 56 DKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG-GKL 114
DK ++KA++AA A + W ++R ++ K AD++ R ++M G GK
Sbjct: 98 DKSLLNKAIEAALAARK---EWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKT 154
Query: 115 YSNAYLNDLAGCIKTLRYCAGWADKIQGR---TIPIDGNFFTYTRHEPIGVCGQIIPWNF 171
A ++ A I R+ A +A +++G+ ++P N Y E G I P+NF
Sbjct: 155 VIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--GFVAAISPFNF 212
Query: 172 PLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGA 231
+ PAL GN V+ KP++ L + V +++EAG PP ++ VP GP G
Sbjct: 213 TAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGD 271
Query: 232 AISSHMDIDKVAFTGSTEVGK-LIKEAAGK----SNLKRVTLELGGKSPCIVLADADLDN 286
++S + + FTGS K L K+ A R+ E GGK+ V AD+++
Sbjct: 272 TVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVES 331
Query: 287 AVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTP-GVTQGPQ 345
V F + GQ C A SR++V S++ + R +E + +G+P G
Sbjct: 332 VVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAV 391
Query: 346 IDKEQYDKILDLIESGKKEGAKLECGGGPWGNK-GYFVQPTVFSNVTDEMRIAKEEIFGP 404
ID + + +I +E + + GG + GYFV+P + + + I KEEIFGP
Sbjct: 392 IDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGP 451
Query: 405 VQQIMKFKSLDDVIKRA-----NNTFYGLSAGVFTKDIDKAITISSALQ--AGTVWVN-- 455
V + + DD K + T YGL+ VF++D D + L+ AG ++N
Sbjct: 452 VLSVYVYP--DDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDK 509
Query: 456 CYGVVSAQCPFGGFKMSGNGRELG 479
G + Q PFGG + SG + G
Sbjct: 510 STGSIVGQQPFGGARASGTNDKPG 533
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 152 bits (385), Expect = 5e-37
Identities = 133/447 (29%), Positives = 209/447 (46%), Gaps = 30/447 (6%)
Query: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY 119
+ +AVK AR AF G RT R + L L LI+ L + + K NAY
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 120 LNDLAGCIKTLRYCAG----WADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVM 175
++ ++ + Y WA P Y EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235
I + A++ GN+VV+KP+E + A +A++I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
Query: 236 HMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGV 295
D + +TGST VGK+I AA K +L VTLELGGKSPC V + DLD A G
Sbjct: 180 RFD--HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 296 FYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKIL 355
F + GQ C+A I + SI ++ V + ++++ K G G I + +++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 356 DLIESGKKEGAKLECGG-GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSL 414
LI EG K+ GG G + ++ PT+ ++V + + +EEIFGPV I+ +SL
Sbjct: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
Query: 415 DDVIKRANNTFYGLSAGVFTKDIDKAI------TISSALQAGTVWVNCYGVVSAQCPFGG 468
++ I+ N L+ +F+ + DK I T S + A V V+ + PFGG
Sbjct: 349 EEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAANDVIVH---ITLHSLPFGG 404
Query: 469 FKMSGNGRELGEYGFHEYTEVKTVTVK 495
SG G G+ F ++ ++ V+
Sbjct: 405 VGNSGMGSYHGKKSFETFSHRRSCLVR 431
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 152 bits (385), Expect = 5e-37
Identities = 133/447 (29%), Positives = 209/447 (46%), Gaps = 30/447 (6%)
Query: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY 119
+ +AVK AR AF G RT R + L L LI+ L + + K NAY
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 120 LNDLAGCIKTLRYCAG----WADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVM 175
++ ++ + Y WA P Y EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235
I + A++ GN+VV+KP+E + A +A++I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
Query: 236 HMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGV 295
D + +TGST VGK+I AA K +L VTLELGGKSPC V + DLD A G
Sbjct: 180 RFD--HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 296 FYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKIL 355
F + GQ C+A I + SI ++ V + ++++ K G G I + +++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 356 DLIESGKKEGAKLECGG-GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSL 414
LI EG K+ GG G + ++ PT+ ++V + + +EEIFGPV I+ +SL
Sbjct: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
Query: 415 DDVIKRANNTFYGLSAGVFTKDIDKAI------TISSALQAGTVWVNCYGVVSAQCPFGG 468
++ I+ N L+ +F+ + DK I T S + A V V+ + PFGG
Sbjct: 349 EEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAANDVIVH---ITLHSLPFGG 404
Query: 469 FKMSGNGRELGEYGFHEYTEVKTVTVK 495
SG G G+ F ++ ++ V+
Sbjct: 405 VGNSGMGSYHGKKSFETFSHRRSCLVR 431
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 152 bits (385), Expect = 5e-37
Identities = 133/447 (29%), Positives = 209/447 (46%), Gaps = 30/447 (6%)
Query: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY 119
+ +AVK AR AF G RT R + L L LI+ L + + K NAY
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 120 LNDLAGCIKTLRYCAG----WADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVM 175
++ ++ + Y WA P Y EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235
I + A++ GN+VV+KP+E + A +A++I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
Query: 236 HMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGV 295
D + +TGST VGK+I AA K +L VTLELGGKSPC V + DLD A G
Sbjct: 180 RFD--HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 296 FYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKIL 355
F + GQ C+A I + SI ++ V + ++++ K G G I + +++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 356 DLIESGKKEGAKLECGG-GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSL 414
LI EG K+ GG G + ++ PT+ ++V + + +EEIFGPV I+ +SL
Sbjct: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
Query: 415 DDVIKRANNTFYGLSAGVFTKDIDKAI------TISSALQAGTVWVNCYGVVSAQCPFGG 468
++ I+ N L+ +F+ + DK I T S + A V V+ + PFGG
Sbjct: 349 EEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAANDVIVH---ITLHSLPFGG 404
Query: 469 FKMSGNGRELGEYGFHEYTEVKTVTVK 495
SG G G+ F ++ ++ V+
Sbjct: 405 VGNSGMGSYHGKKSFETFSHRRSCLVR 431
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 139 bits (349), Expect = 8e-33
Identities = 107/357 (29%), Positives = 169/357 (47%), Gaps = 18/357 (5%)
Query: 146 PIDGNFFT-----YTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200
P+ N T Y + +P+GV I WN+P V+ I + A++ GN V++KP+E +
Sbjct: 83 PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSEN 142
Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260
TA +A L+ + + I G T D + +TG+T VGK++ EAA K
Sbjct: 143 TAKILAKLLPQYLDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK 199
Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320
+L VTLELGGKSPC + D DLD G + + GQ CIA I E S+ ++ V
Sbjct: 200 -HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIV 258
Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380
+ E K++ G + I+ + +IL L+ EG K+ GG
Sbjct: 259 WKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKI-AFGGETDEATR 311
Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440
++ PTV ++V + ++ +EEIFGP+ I+ K++D+ I N L+ VF+ +
Sbjct: 312 YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLI 371
Query: 441 ITISSALQAGTVWVN--CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495
+ +G V N PFGG SG G G++ F ++ + +K
Sbjct: 372 KRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 139 bits (349), Expect = 8e-33
Identities = 107/357 (29%), Positives = 169/357 (47%), Gaps = 18/357 (5%)
Query: 146 PIDGNFFT-----YTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPL 200
P+ N T Y + +P+GV I WN+P V+ I + A++ GN V++KP+E +
Sbjct: 83 PVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSEN 142
Query: 201 TALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGK 260
TA +A L+ + + I G T D + +TG+T VGK++ EAA K
Sbjct: 143 TAKILAKLLPQYLDQDLYIVINGGVEETTELL---KQRFDHIFYTGNTAVGKIVMEAAAK 199
Query: 261 SNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFV 320
+L VTLELGGKSPC + D DLD G + + GQ CIA I E S+ ++ V
Sbjct: 200 -HLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIV 258
Query: 321 RRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY 380
+ E K++ G + I+ + +IL L+ EG K+ GG
Sbjct: 259 WKIKETVKEF-YGENIKESPDYERIINLRHFKRILSLL-----EGQKI-AFGGETDEATR 311
Query: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440
++ PTV ++V + ++ +EEIFGP+ I+ K++D+ I N L+ VF+ +
Sbjct: 312 YIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLI 371
Query: 441 ITISSALQAGTVWVN--CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495
+ +G V N PFGG SG G G++ F ++ + +K
Sbjct: 372 KRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 135 bits (341), Expect = 7e-32
Identities = 132/478 (27%), Positives = 204/478 (42%), Gaps = 80/478 (16%)
Query: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDAS 83
++N +W P +P T E L + EDV AV+AAR AF+ W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
Query: 84 ERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGR 143
R + L +LA++I++ + LL T+ES+ G+ D+ + L Y A IQ
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAS 154
Query: 144 TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV--VKPAEQTPLT 201
T EP+GV G I+P F + ++W+I PAL+ G TVV V PA PL
Sbjct: 155 T-----QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLL 209
Query: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVG--KLIKEAAG 259
+A L E G PG++N++ G ++S I KVAF G+ E G LI+E+
Sbjct: 210 ---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLRLLIQESVW 265
Query: 260 KSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEF 319
++R+ +G + + LD AV+ G C +
Sbjct: 266 DEAMRRLQERMGR-----LRSGRGLDGAVDMGARGA----AAC---------------DL 301
Query: 320 VRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKG 379
V+R V A+ +QG Q+ + G P ++
Sbjct: 302 VQRFVREAQ------------SQGAQV---------------------FQAGDVP--SER 326
Query: 380 YFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDK 439
F PT+ SN+ A+ E+ PV F++ + + AN T G SA V+++ + +
Sbjct: 327 PFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQ 386
Query: 440 AITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKIS 497
A+ + LQ GTVW+N +G+ P GG K SG G G +EY ++S
Sbjct: 387 ALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLS 444
Score = 89.0 bits (219), Expect = 9e-18
Identities = 70/223 (31%), Positives = 103/223 (46%), Gaps = 13/223 (5%)
Query: 52 VEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG 111
V EG +D+ AV+AA QAF W R LL+ LA +ER + LA+ G
Sbjct: 507 VAEGGAKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQG 563
Query: 112 GKLYSNAYLNDLAGCIKTLRYCAGWADKIQ--GRTIPIDGNFFTYTR-HEPIGVCGQIIP 168
+L + +L+ R W ++Q G T+ + G R EP+GV + P
Sbjct: 564 AELKAAEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCP 618
Query: 169 WNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPT 228
+PL+ + + PAL+ GNTVV+ P+ PL AL V + FP G+ N+V G
Sbjct: 619 DEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDH 677
Query: 229 AGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELG 271
++ H D+ + + GS + G E A NLK V G
Sbjct: 678 LTRCLALHQDVQAMWYFGSAQ-GSQFVEWASAGNLKPVWASRG 719
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 122 bits (305), Expect = 1e-27
Identities = 112/436 (25%), Positives = 192/436 (44%), Gaps = 32/436 (7%)
Query: 64 VKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDL 123
++ R+AF G RT A R L L ++ ++ LL + + K + ++++
Sbjct: 8 LRRLREAFHAG---RTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEV 64
Query: 124 A----GCIKTLRYCAGWADKIQGRTIP------IDGNFFTYTRHEPIGVCGQIIPWNFPL 173
A LR W ++ +P +D F R EP G+ I PWN+PL
Sbjct: 65 AISQGEVTLALRNLRAW---MKDERVPKNLATQLDSAFI---RKEPFGLVLIIAPWNYPL 118
Query: 174 VMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAI 233
+ + + AL+ GN VV+KP+E + +A ++ + +V G GP +
Sbjct: 119 NLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQL 176
Query: 234 SSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHH 293
H D + FTGS VGK++ AA K +L VTLELGGK+PC V + D
Sbjct: 177 LEHR-FDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGKNPCYVDDNCDPQTVANRVAW 234
Query: 294 GVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDK 353
+++ GQ C+A + + + + ++ +P + G I+++Q+ +
Sbjct: 235 FRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQS-SPNLGRIINQKQFQR 293
Query: 354 ILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKS 413
+ L+ G+ GG ++ PTV +V + + +EEIFGP+ I+ +S
Sbjct: 294 LRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS 347
Query: 414 LDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKM 471
LD+ I+ N L+ F+ + + +G N + A PFGG
Sbjct: 348 LDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGA 407
Query: 472 SGNGRELGEYGFHEYT 487
SG GR G++ F ++
Sbjct: 408 SGMGRYHGKFSFDTFS 423
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 122 bits (305), Expect = 1e-27
Identities = 112/436 (25%), Positives = 192/436 (44%), Gaps = 32/436 (7%)
Query: 64 VKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDL 123
++ R+AF G RT A R L L ++ ++ LL + + K + ++++
Sbjct: 8 LRRLREAFHAG---RTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEV 64
Query: 124 A----GCIKTLRYCAGWADKIQGRTIP------IDGNFFTYTRHEPIGVCGQIIPWNFPL 173
A LR W ++ +P +D F R EP G+ I PWN+PL
Sbjct: 65 AISQGEVTLALRNLRAW---MKDERVPKNLATQLDSAFI---RKEPFGLVLIIAPWNYPL 118
Query: 174 VMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAI 233
+ + + AL+ GN VV+KP+E + +A ++ + +V G GP +
Sbjct: 119 NLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY-VDQSCFAVVLG-GPQETGQL 176
Query: 234 SSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHH 293
H D + FTGS VGK++ AA K +L VTLELGGK+PC V + D
Sbjct: 177 LEHR-FDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGKNPCYVDDNCDPQTVANRVAW 234
Query: 294 GVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDK 353
+++ GQ C+A + + + + ++ +P + G I+++Q+ +
Sbjct: 235 FRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQS-SPNLGRIINQKQFQR 293
Query: 354 ILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKS 413
+ L+ G+ GG ++ PTV +V + + +EEIFGP+ I+ +S
Sbjct: 294 LRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQS 347
Query: 414 LDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFKM 471
LD+ I+ N L+ F+ + + +G N + A PFGG
Sbjct: 348 LDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGA 407
Query: 472 SGNGRELGEYGFHEYT 487
SG GR G++ F ++
Sbjct: 408 SGMGRYHGKFSFDTFS 423
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 121 bits (303), Expect = 2e-27
Identities = 92/336 (27%), Positives = 155/336 (46%), Gaps = 13/336 (3%)
Query: 154 YTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAG 213
+ R EP G+ I PWN+PL + + + AL+ GN VV+KP+E + +A ++ +
Sbjct: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
Query: 214 FPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGK 273
+V G GP + H D + FTGS VGK++ AA K +L VTLELGGK
Sbjct: 121 VDQSCFAVVLG-GPQETGQLLEHR-FDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 177
Query: 274 SPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILG 333
+PC V + D +++ GQ C+A + + + + ++
Sbjct: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGD 237
Query: 334 NPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDE 393
+P + G I+++Q+ ++ L+ G+ GG ++ PTV +V +
Sbjct: 238 DPQS-SPNLGRIINQKQFQRLRALLGCGR------VAIGGQSDESDRYIAPTVLVDVQEM 290
Query: 394 MRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVW 453
+ +EEIFGP+ I+ +SLD+ I+ N L+ F+ + + +G
Sbjct: 291 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
Query: 454 VN--CYGVVSAQCPFGGFKMSGNGRELGEYGFHEYT 487
N + A PFGG SG GR G++ F ++
Sbjct: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFS 386
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 119 bits (298), Expect = 6e-27
Identities = 92/341 (26%), Positives = 161/341 (47%), Gaps = 23/341 (6%)
Query: 158 EPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPG 217
EP G+ I PWN+PL + + + AL+ G+ VV+KP+E + T +A ++ +
Sbjct: 22 EPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY-LDQS 80
Query: 218 VVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCI 277
+V G GP + H +D + FTGS VGK++ AA K +L VTLELGGK+PC
Sbjct: 81 CFAVVLG-GPQETGQLLEHK-LDYIFFTGSPRVGKIVMTAATK-HLTPVTLELGGKNPCY 137
Query: 278 VLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLT 337
V + D +++ GQ C+A + + + + ++ +P +
Sbjct: 138 VDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQS 197
Query: 338 PGVTQGPQIDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIA 397
G I+++Q+ ++ L+ G+ GG ++ PTV +V + +
Sbjct: 198 -SPNLGRIINQKQFQRLRALLGCGRV------AIGGQSNESDRYIAPTVLVDVQETEPVM 250
Query: 398 KEEIFGPVQQIMKFKSLDDVIKRANNT-------FYGLSAGVFTKDIDKAITISSALQAG 450
+EEIFGP+ I+ +S+D+ IK N + S+ V + +++ + S G
Sbjct: 251 QEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFGGNEG 310
Query: 451 TVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKT 491
+++ V PFGG SG GR G++ F ++ +T
Sbjct: 311 FTYISLLSV-----PFGGVGHSGMGRYHGKFTFDTFSHHRT 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,231,834
Number of Sequences: 37866
Number of extensions: 894646
Number of successful extensions: 1904
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1766
Number of HSP's gapped (non-prelim): 42
length of query: 501
length of database: 18,247,518
effective HSP length: 106
effective length of query: 395
effective length of database: 14,233,722
effective search space: 5622320190
effective search space used: 5622320190
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.